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com.hfg xml, html, svg, and bioinformatics utility library
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package com.hfg.bio.seq;


import com.hfg.util.StringUtil;
import com.hfg.util.collection.OrderedMap;
import com.hfg.util.io.StreamUtil;

import java.io.ByteArrayInputStream;
import java.io.IOException;
import java.util.Collection;
import java.util.Map;
import java.util.regex.Pattern;

//------------------------------------------------------------------------------
/**
 Utility class of generic sequence functions.
 
  @author J. Alex Taylor, hairyfatguy.com
 
 */
//------------------------------------------------------------------------------
// com.hfg Library
//
// This library is free software; you can redistribute it and/or
// modify it under the terms of the GNU Lesser General Public
// License as published by the Free Software Foundation; either
// version 2.1 of the License, or (at your option) any later version.
//
// This library is distributed in the hope that it will be useful,
// but WITHOUT ANY WARRANTY; without even the implied warranty of
// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
// Lesser General Public License for more details.
//
// You should have received a copy of the GNU Lesser General Public
// License along with this library; if not, write to the Free Software
// Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307  USA
//
// J. Alex Taylor, President, Founder, CEO, COO, CFO, OOPS hairyfatguy.com
// [email protected]
//------------------------------------------------------------------------------

public class SeqUtil
{
   private static final Pattern NON_NUC_PATTERN = Pattern.compile("[^ATUGCN]", Pattern.CASE_INSENSITIVE);

   //--------------------------------------------------------------------------
   /**
    Retains only a single copy of each distinct sequence.
    @param inSequences the collection of (potentially redundant) input sequences
    @param  BioSequence-implementing class
    @return the non-redundant collection of sequences
    */
   public static  Collection unique(Collection inSequences)
   {
      Map uniqueMap = new OrderedMap();
      for (T seq : inSequences)
      {
         byte[] checksum = seq.getSHA1Checksum();
         String checksumString = new String(checksum);

         if (! uniqueMap.containsKey(checksumString))
         {
            uniqueMap.put(checksumString, seq);
         }
//         else
//        {
//            System.out.println(seq.getID() + " is a duplicate of " + uniqueMap.get(checksumString).getID());
//         }
      }

      return uniqueMap.values();
   }

   //--------------------------------------------------------------------------
   /**
    Guesses the BioSequenceType for the specified sequence. If the sequence is greater than 80% ATUGCN,
    it will be called as NUCLEIC_ACID. Otherwise it will be called as PROTEIN.
    @param inSequence the sequence to guess the sequence type from
    @return the BioSequenceType of the input sequence
    */
   public static BioSequenceType guessBioSequenceType(String inSequence)
   {
      BioSequenceType guessedType = BioSequenceType.PROTEIN;

      // Is the sequence greater that 80% ATGCN?
      if (StringUtil.replaceAllRegexp(inSequence, NON_NUC_PATTERN, "").length() > (0.8 * inSequence.length()))
      {
         guessedType = BioSequenceType.NUCLEIC_ACID;
      }

      return guessedType;
   }


   //--------------------------------------------------------------------------
   public static String getReverseComplementSequence(String inNucleicAcidSeq)
   {
      String outRevCompSeq;

      try
      {
         outRevCompSeq = StreamUtil.inputStreamToString(new NucleicAcidComplementFilterInputStream(new ByteArrayInputStream(new StringBuilder(inNucleicAcidSeq).reverse().toString().getBytes())));
      }
      catch (IOException e)
      {
         throw new RuntimeException(e);
      }

      return outRevCompSeq;
   }

   //--------------------------------------------------------------------------
   /**
    * Creates a new SeqLocation that is relative to the opposite strand.
    * Ex: [2, 6] on the reverse strand of a nucleotide sequence of length 10,
    * would be converted to a forward strand relative location of [9, 5].
    * @param inSeqLoc the initial sequence location
    * @param inNucleotideSeqLength the length of the nucleotide sequence containing the location
    * @return  a SeqLocation relative to the opposite strand
    */
   public static SeqLocation flipStrandSeqLocation(SeqLocation inSeqLoc, int inNucleotideSeqLength)
   {
      SeqLocation fwdRelativeSeqLoc = new SeqLocation()
            .setChainId(inSeqLoc.getChainId())
            .setStart(inNucleotideSeqLength - inSeqLoc.getStart() + 1)
            .setEnd(inNucleotideSeqLength - inSeqLoc.getEnd() + 1);

      return fwdRelativeSeqLoc;
   }
}