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lidator.biopax-validator.5.1.0.source-code.cl.obo Maven / Gradle / Ivy

format-version: 1.2
data-version: releases/2017-07-29
subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis"
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: LATIN "latin term"
synonymtypedef: PLURAL "plural term"
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 75 Logical Axioms: 29]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 10 Logical Axioms: 3]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 3074 Logical Axioms: 1380]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 1503 Logical Axioms: 347]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 187 Logical Axioms: 65]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 2196 Logical Axioms: 219]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 387 Logical Axioms: 156]
remark: Includes Ontology(OntologyID(OntologyIRI() VersionIRI())) [Axioms: 28302 Logical Axioms: 9682]
remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, [email protected], University at Buffalo.
ontology: cl
property_value: http://purl.org/dc/elements/1.1/license http://creativecommons.org/licenses/by/4.0/
owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\nDeclaration(ObjectProperty())\n############################\n#   Object Properties\n############################\n\n# Object Property:  (synapsed by)\n\nObjectPropertyRange( ObjectUnionOf( ObjectSomeValuesFrom( )))\n\n\n############################\n#   Classes\n############################\n\n# Class:  (cholinergic neuron)\n\nEquivalentClasses( ObjectSomeValuesFrom( ))\n\n# Class:  (ILC1)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectComplementOf(ObjectSomeValuesFrom( ))))\n\n# Class:  (smooth muscle cell of the brain vasculature)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (compound eye retinal cell)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (magnocellular neurosecretory cell)\n\nSubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectIntersectionOf( ObjectSomeValuesFrom( )))\n\n# Class:  (gastric cardiac gland goblet cell)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (large intestine crypt goblet cell)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (pylroric gastric gland goblet cell)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (jejunal goblet cell)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (ileal goblet cell)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (appendix goblet cell)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (cholangiocyte)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))\n\n# Class:  (cardiac neural crest)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (mouth)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (scalp)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (organism subdivision)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (sensory system)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (hepatic acinus)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (umbilical artery)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (anal region)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (hip)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (shoulder)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (muscle of shoulder)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (subclavian artery)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (temporal bone)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (jaw skeleton)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (optic choroid)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (mucosa-associated lymphoid tissue)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (bronchial-associated lymphoid tissue)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (hindbrain)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (umbilical vein)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (hair follicle)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (appendicular skeleton)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (liver)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (chondrocranium)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (olfactory organ)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (extraglomerular mesangium)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (tympanic membrane)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (lateral line system)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (midbrain-hindbrain boundary)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (surface structure)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (skeleton of lower jaw)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (shoulder bone)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (thymus corticomedullary boundary)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (pharyngeal pouch)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (large intestine smooth muscle)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (intestine smooth muscle)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (small intestine smooth muscle)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (allantois)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (entire sense organ system)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (musculature of hip)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (musculature of shoulder)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (somatopleure)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (tela choroidea)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (olfactory system)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (1st arch pharyngeal cleft)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (pharyngeal cleft)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (eye trabecular meshwork)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (buccopharyngeal membrane)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (foregut-midgut junction)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (mouth-foregut junction)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (pharyngeal pouch 1)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (nucleus of midbrain tegmentum)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (bone of hip region)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (pharyngeal membrane)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (pharyngeal membrane of 1st arch)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (medullary ray)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (collection of basal ganglia)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (umbilical blood vessel)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (nasal-associated lymphoid tissue)\n\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (extraembryonic venous system)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n# Class:  (extraembryonic vascular system)\n\nEquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))))\nSubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )))\n\n\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectUnionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectComplementOf(ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nDisjointClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nSubObjectPropertyOf(ObjectPropertyChain( ObjectInverseOf()) )\n)

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []

[Term]
id: BFO:0000004
name: independent continuant
def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
is_a: BFO:0000002 ! continuant

[Term]
id: BFO:0000015
name: process
def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
is_a: BFO:0000003 ! occurrent

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
is_a: BFO:0000002 ! continuant

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant

[Term]
id: CARO:0000003
name: anatomical structure
is_a: CARO:0000006 ! material anatomical entity

[Term]
id: CARO:0000006
name: material anatomical entity
is_a: BFO:0000040 ! material entity

[Term]
id: CARO:0000014
name: cell part
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0001000
name: multi-cell-part structure
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0001001
name: neuron projection bundle
is_a: CARO:0001000 ! multi-cell-part structure

[Term]
id: CHEBI:23367
name: molecular entity
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:24431
name: chemical entity

[Term]
id: CHEBI:24651
name: hydroxides
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:25179
name: melanin
is_a: CHEBI:26195 ! polyphenol

[Term]
id: CHEBI:25367
name: molecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:25806
name: oxygen molecular entity
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:26195
name: polyphenol
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
is_a: CHEBI:33675 ! p-block molecular entity

[Term]
id: CHEBI:33579
name: main group molecular entity
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:33582
name: carbon group molecular entity
is_a: CHEBI:33675 ! p-block molecular entity

[Term]
id: CHEBI:33595
name: cyclic compound
is_a: CHEBI:25367 ! molecule

[Term]
id: CHEBI:33608
name: hydrogen molecular entity
is_a: CHEBI:33674 ! s-block molecular entity

[Term]
id: CHEBI:33655
name: aromatic compound
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33659
name: organic aromatic compound
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33674
name: s-block molecular entity
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:33675
name: p-block molecular entity
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:33822
name: organic hydroxy compound
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33832
name: organic cyclic compound
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:33853
name: phenols
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:36357
name: polyatomic entity
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:50860
name: organic molecular entity
is_a: CHEBI:33582 ! carbon group molecular entity

[Term]
id: CHEBI:72695
name: organic molecule
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CL:0000000
name: cell
namespace: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
is_a: CARO:0000003 ! anatomical structure
is_a: GO:0005575 ! cellular_component
equivalent_to: GO:0005623 ! cell

[Term]
id: CL:0000001
name: primary cultured cell
namespace: cell
def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [ReO:mhb]
comment: Covers cells actively being cultured or stored in a quiescent state for future use.
synonym: "primary cell culture cell" EXACT []
synonym: "primary cell line cell" RELATED []
synonym: "unpassaged cultured cell" EXACT []
xref: BTO:0002290
is_a: CL:0000010 ! cultured cell

[Term]
id: CL:0000002
name: obsolete immortal cell line cell
namespace: cell
def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb]
comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use.
synonym: "continuous cell line cell" EXACT []
synonym: "permanent cell line cell" EXACT []
is_obsolete: true
replaced_by: CLO:0000019

[Term]
id: CL:0000003
name: native cell
namespace: cell
def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah]
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).
subset: ubprop:upper_level
synonym: "cell in vivo" NARROW []
xref: CARO:0000013
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell

[Term]
id: CL:0000004
name: obsolete cell by organism
namespace: cell
def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [FB:ma]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000005
name: fibroblast neural crest derived
namespace: cell
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000006
name: neuronal receptor cell
namespace: cell
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! receptor cell
intersection_of: CL:0000197 ! receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000007
name: early embryonic cell
namespace: cell
def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm]
is_a: CL:0002321 ! embryonic cell

[Term]
id: CL:0000008
name: migratory cranial neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000009
name: obsolete fusiform initial
namespace: cell
alt_id: CL:0000274
def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208]
comment: replaced_by: PO:0000079
synonym: "xylem initial" RELATED []
synonym: "xylem mother cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000010
name: cultured cell
namespace: cell
def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb]
comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. 
is_a: CL:0000578 ! experimentally modified cell in vitro

[Term]
id: CL:0000011
name: migratory trunk neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000012
name: obsolete cell by class
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000013
name: obsolete dentine secreting cell
namespace: cell
is_obsolete: true
consider: CL:0000140

[Term]
id: CL:0000014
name: germ line stem cell
namespace: cell
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 {is_inferred="true"} ! stem cell
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000015
name: male germ cell
namespace: cell
xref: FMA:72290
xref: MA:0002765
xref: ncithesaurus:Spermatogenic_Cell
xref: VHOG:0001531
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0007283 ! spermatogenesis
relationship: capable_of GO:0007283 ! spermatogenesis

[Term]
id: CL:0000016
name: male germ line stem cell
namespace: cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000017
name: spermatocyte
namespace: cell
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880]
xref: BTO:0001275
xref: CALOHA:TS-0951
xref: EMAPA:31484
xref: FBbt:00004936
xref: FMA:84049
xref: WBbt:0006799
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0048137 ! spermatocyte division
relationship: capable_of GO:0048137 ! spermatocyte division
relationship: develops_from CL:0000020 ! spermatogonium

[Term]
id: CL:0000018
name: spermatid
namespace: cell
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860]
synonym: "nematoblast" EXACT []
xref: BTO:0001274
xref: CALOHA:TS-0950
xref: EMAPA:31486
xref: FBbt:00004942
xref: FMA:72294
xref: WBbt:0006800
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: bearer_of PATO:0001375 ! haploid
intersection_of: capable_of GO:0001675 ! acrosome assembly
intersection_of: capable_of GO:0007288 ! sperm axoneme assembly
intersection_of: capable_of GO:0007289 ! spermatid nucleus differentiation
relationship: bearer_of PATO:0001375 ! haploid
relationship: capable_of GO:0001675 ! acrosome assembly
relationship: capable_of GO:0007288 ! sperm axoneme assembly
relationship: capable_of GO:0007289 ! spermatid nucleus differentiation
relationship: develops_from CL:0000657 ! secondary spermatocyte

[Term]
id: CL:0000019
name: sperm
namespace: cell
def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890]
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: BTO:0001277
xref: BTO:0002046
xref: CALOHA:TS-0949
xref: FBbt:00004954
xref: FMA:67338
xref: WBbt:0006798
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000219 ! motile cell
is_a: CL:0000408 {is_inferred="true"} ! male gamete
intersection_of: CL:0000408 ! male gamete
intersection_of: capable_of GO:0030317 ! sperm motility
intersection_of: capable_of GO:0048240 ! sperm capacitation
relationship: capable_of GO:0030317 ! sperm motility
relationship: capable_of GO:0048240 ! sperm capacitation
relationship: develops_from CL:0000018 ! spermatid
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0000020
name: spermatogonium
namespace: cell
def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900]
xref: BTO:0000958
xref: CALOHA:TS-2193
xref: EMAPA:31482
xref: FBbt:00004935
xref: FMA:72291
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: bearer_of PATO:0001394 ! diploid
intersection_of: bearer_of PATO:0001501 ! immature
relationship: bearer_of PATO:0001394 ! diploid
relationship: bearer_of PATO:0001501 ! immature

[Term]
id: CL:0000021
name: female germ cell
namespace: cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0048477 ! oogenesis
relationship: capable_of GO:0048477 ! oogenesis

[Term]
id: CL:0000022
name: female germ line stem cell
namespace: cell
is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000023
name: oocyte
namespace: cell
def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544]
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FBbt:00004886
xref: FMA:18644
xref: WBbt:0006797
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
relationship: participates_in GO:0007143 ! female meiotic division

[Term]
id: CL:0000024
name: oogonial cell
namespace: cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
xref: FMA:83673
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0007067 ! mitotic nuclear division
relationship: capable_of GO:0007067 ! mitotic nuclear division
relationship: develops_from CL:0000670 ! primordial germ cell

[Term]
id: CL:0000025
name: egg cell
namespace: cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544]
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FBbt:00057012
xref: FMA:67343
xref: MA:0000388
is_a: CL:0000675 {is_inferred="true"} ! female gamete
relationship: develops_from CL:0000023 ! oocyte
relationship: participates_in GO:0007143 ! female meiotic division

[Term]
id: CL:0000026
name: invertebrate nurse cell
namespace: cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391]
synonym: "nurse cell" RELATED []
xref: BTO:0000953
xref: FBbt:00004878
is_a: CL:0000039 ! germ line cell
is_a: CL:0000412 ! polyploid cell
relationship: develops_from CL:0000722 ! cystoblast

[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
namespace: cell
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000028
name: CNS neuron (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000029
name: neuron neural crest derived
namespace: cell
is_a: CL:0000540 {is_inferred="true"} ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0002676 ! neural crest derived neuroblast

[Term]
id: CL:0000030
name: glioblast
namespace: cell
xref: FBbt:00005145
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000031
name: neuroblast
namespace: cell
def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast]
xref: BTO:0000930
xref: FBbt:00005146
xref: FMA:70563
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000032
name: neuroplacodal cell
namespace: cell
def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256]
synonym: "neural placode cell" EXACT []
is_a: CL:0002321 ! embryonic cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000033
name: apocrine cell
namespace: cell
def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000034
name: stem cell
namespace: cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872]
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0030154 ! cell differentiation

[Term]
id: CL:0000035
name: single fate stem cell
namespace: cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm]
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001400 ! unipotent
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: bearer_of PATO:0001400 ! unipotent
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000036
name: epithelial fate stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell

[Term]
id: CL:0000037
name: hematopoietic stem cell
namespace: cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770]
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
xref: FMA:86475
xref: VHOG:0001485
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: capable_of GO:0048103 ! somatic stem cell division
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: capable_of GO:0048103 ! somatic stem cell division
relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000038
name: erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000039
name: germ line cell
namespace: cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children.
subset: ubprop:upper_level
is_a: CL:0000548 ! animal cell
disjoint_from: CL:0002371 ! somatic cell
relationship: capable_of GO:0022414 ! reproductive process

[Term]
id: CL:0000040
name: monoblast
namespace: cell
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
synonym: "CFU-M" RELATED []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: has_part CP:0000028 ! basophilic cytoplasm
intersection_of: has_part GO:0000791 ! euchromatin
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: has_part CP:0000028 ! basophilic cytoplasm
relationship: has_part GO:0000791 ! euchromatin
relationship: has_part GO:0005730 ! nucleolus
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0000041
name: mature eosinophil
namespace: cell
def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464]
comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP.
synonym: "mature eosinocyte" EXACT []
synonym: "mature eosinophil leucocyte" EXACT []
synonym: "mature eosinophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000771 {is_inferred="true"} ! eosinophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000771 ! eosinophil
intersection_of: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
intersection_of: capable_of GO:0002540 ! leukotriene production involved in inflammatory response
intersection_of: capable_of GO:0045730 ! respiratory burst
intersection_of: has_part CP:0000025 ! lobed nucleus
intersection_of: has_part PR:000007152 ! eosinophil peroxidase
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: has_part PR:000014046 ! non-secretory ribonuclease
intersection_of: has_part PR:000014047 ! eosinophil cationic protein
intersection_of: has_part PR:000022006 ! eosinophil granule major basic protein
intersection_of: has_plasma_membrane_part PR:000009129 ! integrin alpha-4
relationship: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: capable_of GO:0002540 ! leukotriene production involved in inflammatory response
relationship: capable_of GO:0045730 ! respiratory burst
relationship: develops_from CL:0000774 ! band form eosinophil
relationship: has_part CP:0000025 ! lobed nucleus
relationship: has_part PR:000007152 ! eosinophil peroxidase
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: has_part PR:000014046 ! non-secretory ribonuclease
relationship: has_part PR:000014047 ! eosinophil cationic protein
relationship: has_part PR:000022006 ! eosinophil granule major basic protein
relationship: has_plasma_membrane_part PR:000009129 ! integrin alpha-4

[Term]
id: CL:0000042
name: neutrophilic myeloblast
namespace: cell
def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007]
comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
synonym: "neutrophilic granuloblast" RELATED []
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000835 {is_inferred="true"} ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030223 ! neutrophil differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000010799 ! myb proto-oncogene protein
intersection_of: has_part PR:000014362 ! runt-related transcription factor 1
relationship: capable_of GO:0030223 ! neutrophil differentiation
relationship: develops_from CL:0000834 ! neutrophil progenitor cell
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000010799 ! myb proto-oncogene protein
relationship: has_part PR:000014362 ! runt-related transcription factor 1

[Term]
id: CL:0000043
name: mature basophil
namespace: cell
alt_id: CL:0000739
def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449]
comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4.
synonym: "mature basophil leucocyte" EXACT []
synonym: "mature basophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0001026
xref: CALOHA:TS-0688
is_a: CL:0000767 {is_inferred="true"} ! basophil
is_a: CL:0002242 ! nucleate cell
is_a: CL:0002274 ! histamine secreting cell
intersection_of: CL:0000767 ! basophil
intersection_of: capable_of GO:0002349 ! histamine production involved in inflammatory response
intersection_of: capable_of GO:0002351 ! serotonin production involved in inflammatory response
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: capable_of GO:0032616 ! interleukin-13 production
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes
intersection_of: has_part CP:0000025 ! lobed nucleus
relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response
relationship: capable_of GO:0002351 ! serotonin production involved in inflammatory response
relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response
relationship: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0032616 ! interleukin-13 production
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes
relationship: develops_from CL:0000770 ! band form basophil
relationship: has_part CP:0000025 ! lobed nucleus

[Term]
id: CL:0000045
name: obsolete thymus processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000046
name: obsolete bursa processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000047
name: neuronal stem cell
namespace: cell
def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, http://en.wikipedia.org/wiki/Neural_stem_cell, MESH:D058953, PMID:15247488]
synonym: "neural stem cell" EXACT []
synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000048
name: multi fate stem cell
namespace: cell
def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add]
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
is_a: CL:0000034 ! stem cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: bearer_of PATO:0001402 ! multipotent
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: bearer_of PATO:0001402 ! multipotent
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000049
name: common myeloid progenitor
namespace: cell
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor.  For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
synonym: "CFU-GEMM" RELATED [ISBN:0878932437]
synonym: "CFU-S" RELATED [ISBN:0878932437]
synonym: "CMP" EXACT [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
xref: BTO:0004730
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566]
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000051
name: common lymphoid progenitor
namespace: cell
alt_id: CL:0000044
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
synonym: "CLP" EXACT []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
relationship: capable_of GO:0030098 ! lymphocyte differentiation

[Term]
id: CL:0000052
name: totipotent stem cell
namespace: cell
def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm]
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000054
name: bone matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000055
name: non-terminally differentiated cell
namespace: cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
comment: define using PATO mulit-potent or oligopotent?
synonym: "blast cell" EXACT []
xref: BTO:0000125
xref: FMA:84782
is_a: CL:0011115 ! precursor cell
relationship: capable_of GO:0030154 ! cell differentiation

[Term]
id: CL:0000056
name: myoblast
namespace: cell
def: "A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:A11.635, PMID:21849021]
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FBbt:00005083
xref: FMA:70335
xref: VHOG:0001529
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000057
name: fibroblast
namespace: cell
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347]
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: VHOG:0001482
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000058
name: chondroblast
namespace: cell
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256]
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007009 ! prechondroblast
relationship: produces UBERON:0002418 ! cartilage tissue

[Term]
id: CL:0000059
name: ameloblast
namespace: cell
alt_id: CL:0000053
alt_id: CL:0000139
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107]
comment: non-encoded relationship from VSAO produces VSAO:0000066
synonym: "amelocyte" EXACT []
synonym: "enamel secreting cell" EXACT []
xref: BTO:0001663
xref: FMA:70576
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: adjacent_to UBERON:0001763 ! odontogenic papilla
relationship: capable_of GO:0097186 ! amelogenesis
relationship: develops_from CL:0007000 ! preameloblast
relationship: part_of UBERON:0005176 ! tooth enamel organ
relationship: produces UBERON:0001752 ! enamel

[Term]
id: CL:0000060
name: odontoblast
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256]
comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.
xref: BTO:0001769
xref: CALOHA:TS-0696
xref: FMA:62999
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
relationship: develops_from CL:0007003 ! preodontoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ
relationship: produces UBERON:0001751 ! dentine

[Term]
id: CL:0000061
name: cementoblast
namespace: cell
alt_id: CL:0000859
def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901]
comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth.
synonym: "cementum secreting cell" EXACT []
xref: CALOHA:TS-1164
xref: FMA:63002
is_a: CL:0000062 ! osteoblast
is_a: CL:0000151 ! secretory cell
relationship: develops_from CL:0007002 ! precementoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ
relationship: produces UBERON:0001753 ! cementum

[Term]
id: CL:0000062
name: osteoblast
namespace: cell
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629]
comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020
xref: BTO:0001593
xref: CALOHA:TS-0720
xref: FMA:66780
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007010 ! preosteoblast
relationship: produces UBERON:0008883 ! osteoid

[Term]
id: CL:0000063
name: obsolete cell by histology
namespace: cell
def: "OBSOLETE: A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000064
name: ciliated cell
namespace: cell
def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm]
xref: VHOG:0001532
xref: XAO:0000031
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: has_plasma_membrane_part GO:0005929 ! cilium
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0000065
name: ependymal cell
namespace: cell
def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134]
synonym: "ependymocyte" EXACT []
xref: BTO:0001724
xref: FMA:70550
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0000066
name: epithelial cell
namespace: cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436]
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FBbt:00000124
xref: FMA:66768
xref: WBbt:0003672
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000483 ! epithelium
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium

[Term]
id: CL:0000067
name: ciliated epithelial cell
namespace: cell
def: "An epithelial cell that has a cillia." [GOC:tfm]
xref: FMA:70605
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_plasma_membrane_part GO:0005929 ! cilium
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0000068
name: duct epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000058 ! duct
relationship: part_of UBERON:0000058 ! duct

[Term]
id: CL:0000069
name: branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell

[Term]
id: CL:0000070
name: obsolete epithelial cell of gland
namespace: cell
is_obsolete: true

[Term]
id: CL:0000071
name: blood vessel endothelial cell
namespace: cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
synonym: "cuboidal endothelial cell of vascular tree" EXACT []
is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0004638 ! blood vessel endothelium
relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell
relationship: part_of UBERON:0004638 ! blood vessel endothelium

[Term]
id: CL:0000072
name: non-branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000073
name: barrier epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000074
name: obsolete epithem cell
namespace: cell
def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305]
comment: replaced_by: PO:0000066
is_obsolete: true

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000076
name: squamous epithelial cell
namespace: cell
xref: CALOHA:TS-1249
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000077
name: mesothelial cell
namespace: cell
def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544]
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000078
name: peridermal cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000079
name: stratified epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:0000080
name: circulating cell
namespace: cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0000179 ! haemolymphatic fluid

[Term]
id: CL:0000081
name: blood cell
namespace: cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
xref: FMA:62844
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0008015 ! blood circulation

[Term]
id: CL:0000082
name: epithelial cell of lung
namespace: cell
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000115 ! lung epithelium
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:0000083
name: epithelial cell of pancreas
namespace: cell
def: "An epithelial cell of the pancreas." [GOC:tfm]
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0000223 ! endodermal cell
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0000084
name: T cell
namespace: cell
alt_id: CL:0000804
alt_id: CL:0000812
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: VHOG:0001479
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0002456 ! T cell mediated immunity
disjoint_from: CL:0000623 ! natural killer cell
disjoint_from: CL:0000945 ! lymphocyte of B lineage
relationship: capable_of GO:0002456 ! T cell mediated immunity
relationship: develops_from CL:0000827 ! pro-T cell

[Term]
id: CL:0000085
name: germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000014 ! germ line stem cell

[Term]
id: CL:0000086
name: germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004861
is_a: CL:0000014 ! germ line stem cell

[Term]
id: CL:0000087
name: male germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004929
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000088
name: female germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004873
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000089
name: male germ line stem cell (sensu Vertebrata)
namespace: cell
synonym: "spermatogonial stem cell" EXACT [PMID:19948499]
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000090
name: female germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000091
name: Kupffer cell
namespace: cell
def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582]
comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
synonym: "hepatic macrophage" EXACT []
synonym: "littoral cell of hepatic sinusoid" EXACT []
synonym: "liver macrophage" EXACT []
synonym: "macrophagocytus stellatus" EXACT []
synonym: "stellate cell of von Kupffer" EXACT []
synonym: "von Kupffer cell" EXACT []
xref: BTO:0000685
xref: FMA:14656
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0034102 ! erythrocyte clearance
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: located_in UBERON:0001281 ! hepatic sinusoid
relationship: capable_of GO:0034102 ! erythrocyte clearance
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: located_in UBERON:0001281 ! hepatic sinusoid

[Term]
id: CL:0000092
name: osteoclast
namespace: cell
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
synonym: "chondroclast" RELATED []
xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0001035 {is_inferred="true"} ! bone cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0045453 ! bone resorption
intersection_of: has_part PR:000001850 ! cathepsin K
intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos
intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit
intersection_of: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: part_of UBERON:0001474 ! bone element
relationship: capable_of GO:0045453 ! bone resorption
relationship: develops_from CL:0000576 ! monocyte
relationship: has_part PR:000001850 ! cathepsin K
relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000007597 ! proto-oncogene c-Fos
relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit
relationship: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: CL:0000093
name: obsolete osteochondroclast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using 'osteoclast ; CL:0000092' instead.
is_obsolete: true

[Term]
id: CL:0000094
name: granulocyte
namespace: cell
def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098]
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: has_part GO:0030141 ! secretory granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8
intersection_of: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0008015 ! blood circulation
relationship: has_part GO:0030141 ! secretory granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8
relationship: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000095
name: neuron associated cell
namespace: cell
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000096
name: mature neutrophil
namespace: cell
def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A11.118.637.415.583, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385]
comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).
synonym: "mature neutrocyte" EXACT []
synonym: "mature neutrophil leucocyte" EXACT []
synonym: "mature neutrophil leukocyte" EXACT []
synonym: "mature neutrophilic leucocyte" EXACT []
synonym: "mature neutrophilic leukocyte" EXACT []
synonym: "PMN" EXACT []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" EXACT []
synonym: "polynuclear neutrophilic leucocyte" EXACT []
synonym: "polynuclear neutrophilic leukocyte" EXACT []
xref: BTO:0003473
is_a: CL:0000234 ! phagocyte
is_a: CL:0000775 {is_inferred="true"} ! neutrophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000775 ! neutrophil
intersection_of: capable_of GO:0002536 ! respiratory burst involved in inflammatory response
intersection_of: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0032637 ! interleukin-8 production
intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm
intersection_of: has_part CP:0000025 ! lobed nucleus
intersection_of: has_part GO:0070820 ! tertiary granule
intersection_of: has_plasma_membrane_part PR:000001256 ! C-X-C chemokine receptor type 1
intersection_of: has_plasma_membrane_part PR:000001257 ! C-X-C chemokine receptor type 2
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1
intersection_of: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos
intersection_of: lacks_part PR:000009978 ! lactotransferrin
intersection_of: lacks_part PR:000010543 ! myeloperoxidase
intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein
relationship: capable_of GO:0002536 ! respiratory burst involved in inflammatory response
relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0032637 ! interleukin-8 production
relationship: has_part CP:0000000 ! neutrophillic cytoplasm
relationship: has_part CP:0000025 ! lobed nucleus
relationship: has_part GO:0070820 ! tertiary granule
relationship: has_plasma_membrane_part PR:000001256 ! C-X-C chemokine receptor type 1
relationship: has_plasma_membrane_part PR:000001257 ! C-X-C chemokine receptor type 2
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1
relationship: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos
relationship: lacks_part PR:000009978 ! lactotransferrin
relationship: lacks_part PR:000010543 ! myeloperoxidase
relationship: lacks_part PR:000010799 ! myb proto-oncogene protein

[Term]
id: CL:0000097
name: mast cell
namespace: cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811]
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
synonym: "histaminocyte" EXACT []
synonym: "labrocyte" EXACT [ISBN:0721601464]
synonym: "mastocyte" EXACT [ISBN:0721601464]
synonym: "tissue basophil" RELATED [ISBN:068340007X]
xref: BTO:0000830
xref: CALOHA:TS-0603
xref: FMA:66784
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0002349 ! histamine production involved in inflammatory response
intersection_of: capable_of GO:0002539 ! prostaglandin production involved in inflammatory response
intersection_of: capable_of GO:0002660 ! positive regulation of peripheral tolerance induction
intersection_of: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
intersection_of: capable_of GO:0030210 ! heparin biosynthetic process
intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_part GO:0030141 ! secretory granule
intersection_of: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3
intersection_of: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3
intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response
relationship: capable_of GO:0002539 ! prostaglandin production involved in inflammatory response
relationship: capable_of GO:0002660 ! positive regulation of peripheral tolerance induction
relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis
relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response
relationship: capable_of GO:0030210 ! heparin biosynthetic process
relationship: develops_from CL:0000831 ! mast cell progenitor
relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_part GO:0030141 ! secretory granule
relationship: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3
relationship: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3
relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain

[Term]
id: CL:0000098
name: sensory epithelial cell
namespace: cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! receptor cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000099
name: interneuron
namespace: cell
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358]
xref: BTO:0003811
xref: FBbt:00005125
xref: FMA:67313
xref: WBbt:0005113
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000100
name: motor neuron
namespace: cell
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:A08.663.655.500, PMID:16875686]
synonym: "anterior horn cell" NARROW []
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FMA:83617
xref: WBbt:0005409
is_a: CL:0000527 ! efferent neuron
relationship: synapsed_to CL:0000187 ! muscle cell

[Term]
id: CL:0000101
name: sensory neuron
namespace: cell
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
xref: BTO:0001037
xref: FBbt:00005124
xref: FMA:84649
xref: WBbt:0005759
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000102
name: polymodal neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000103
name: bipolar neuron
namespace: cell
def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442]
xref: FMA:67282
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000104
name: multipolar neuron
namespace: cell
def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm]
xref: FMA:67287
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000105
name: pseudounipolar neuron
namespace: cell
def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm]
xref: FMA:67305
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000106
name: unipolar neuron
namespace: cell
def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv]
xref: FMA:67278
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000107
name: autonomic neuron
namespace: cell
def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm]
xref: FMA:80121
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 ! autonomic nervous system

[Term]
id: CL:0000108
name: cholinergic neuron
namespace: cell
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm]
xref: BTO:0004902
xref: FMA:84796
xref: WBbt:0006840
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000109
name: adrenergic neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000110
name: peptidergic neuron
namespace: cell
is_a: CL:0000540 ! neuron
relationship: capable_of GO:0002790 ! peptide secretion

[Term]
id: CL:0000111
name: peripheral neuron
namespace: cell
def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544]
xref: FMA:84664
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000112
name: columnar neuron
namespace: cell
synonym: "columnar neuron" RELATED []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000113
name: mononuclear phagocyte
namespace: cell
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
xref: BTO:0001433
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: bearer_of PATO:0001407 ! mononucleate
relationship: bearer_of PATO:0001407 ! mononucleate

[Term]
id: CL:0000114
name: surface ectodermal cell
namespace: cell
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT []
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000115
name: endothelial cell
namespace: cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341]
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000116
name: pioneer neuron
namespace: cell
def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm]
xref: FBbt:00005128
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000118
name: basket cell
namespace: cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000119
name: cerebellar Golgi cell
namespace: cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [NIFSTD:sao1415726815]
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: CL:0000120
name: granule cell
namespace: cell
xref: BTO:0003393
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000121
name: Purkinje cell
namespace: cell
def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600]
synonym: "cerebellar Purkinje cell" EXACT []
synonym: "cerebellum Purkinje cell" EXACT []
synonym: "Purkinje neuron" EXACT []
synonym: "Purkinje's cell" EXACT []
xref: BTO:0001011
xref: CALOHA:TS-0845
xref: FMA:67969
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0000527 ! efferent neuron
is_a: CL:1001611 ! cerebellar neuron
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: CL:0000122
name: stellate neuron
namespace: cell
xref: BTO:0002316
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000095 ! neuron associated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000124
name: glial cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005144
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000125
name: glial cell
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637]
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
relationship: develops_from CL:0000030 {comment="It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation."} ! glioblast

[Term]
id: CL:0000126
name: macroglial cell
namespace: cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
xref: FMA:54538
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000127
name: astrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
synonym: "astrocytic glia" EXACT []
xref: BTO:0000099
xref: CALOHA:TS-0060
xref: FMA:54537
is_a: CL:0000126 ! macroglial cell

[Term]
id: CL:0000128
name: oligodendrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836]
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT [PMID:8734446]
xref: BTO:0000962
xref: CALOHA:TS-0709
xref: FMA:54540
is_a: CL:0000126 {is_inferred="true"} ! macroglial cell
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000129
name: microglial cell
namespace: cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" RELATED []
synonym: "microglia" EXACT []
synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/]
xref: BTO:0000078
xref: BTO:0000962
xref: FMA:54539
xref: FMA:54540
is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata)
is_a: CL:0000878 ! central nervous system macrophage
intersection_of: CL:0000243 ! glial cell (sensu Vertebrata)
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: capable_of GO:0045087 ! innate immune response
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000130
name: neuron associated cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000131
name: gut endothelial cell
namespace: cell
is_a: CL:0000115 ! endothelial cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000132
name: corneal endothelial cell
namespace: cell
def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A09.371.060.067.31]
xref: CALOHA:TS-0172
xref: FMA:70614
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000133
name: neurectodermal cell
namespace: cell
def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X]
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000134
name: mesenchymal stem cell
namespace: cell
alt_id: CL:0002452
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
synonym: "BMSC" NARROW []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED PLURAL []
synonym: "MSC" RELATED [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000219 ! motile cell
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: capable_of GO:0001649 ! osteoblast differentiation
intersection_of: capable_of GO:0016477 ! cell migration
intersection_of: capable_of GO:0030182 ! neuron differentiation
intersection_of: capable_of GO:0030855 ! epithelial cell differentiation
intersection_of: capable_of GO:0045444 ! fat cell differentiation
intersection_of: capable_of GO:0055007 ! cardiac muscle cell differentiation
intersection_of: capable_of GO:0060591 ! chondroblast differentiation
intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin
intersection_of: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase
intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: capable_of GO:0001649 ! osteoblast differentiation
relationship: capable_of GO:0016477 ! cell migration
relationship: capable_of GO:0030182 ! neuron differentiation
relationship: capable_of GO:0030855 ! epithelial cell differentiation
relationship: capable_of GO:0045444 ! fat cell differentiation
relationship: capable_of GO:0055007 ! cardiac muscle cell differentiation
relationship: capable_of GO:0060591 ! chondroblast differentiation
relationship: has_plasma_membrane_part PR:000001345 ! endoglin
relationship: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase
relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C

[Term]
id: CL:0000135
name: fibrocyte
namespace: cell
def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999]
comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A.
xref: FMA:63879
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
intersection_of: capable_of GO:0045766 ! positive regulation of angiogenesis
relationship: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: capable_of GO:0045766 ! positive regulation of angiogenesis
relationship: develops_from CL:0000057 ! fibroblast

[Term]
id: CL:0000136
name: fat cell
namespace: cell
alt_id: CL:0000450
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114]
synonym: "adipocyte" EXACT []
synonym: "adipose cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000137
name: osteocyte
namespace: cell
def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500]
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
synonym: "bone cell" BROAD []
xref: BTO:0002038
xref: CALOHA:TS-1167
xref: FMA:66779
xref: VSAO:0000124
is_a: CL:0001035 ! bone cell
relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast
relationship: part_of UBERON:0002481 ! bone tissue

[Term]
id: CL:0000138
name: chondrocyte
namespace: cell
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171]
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
relationship: develops_from CL:0000058 ! chondroblast
relationship: located_in UBERON:0002418 ! cartilage tissue

[Term]
id: CL:0000140
name: odontocyte
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034]
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000060 ! odontoblast
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: produces UBERON:0001751 ! dentine

[Term]
id: CL:0000141
name: cementocyte
namespace: cell
def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901]
comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def).
xref: FMA:63003
is_a: CL:0000137 ! osteocyte
relationship: develops_from CL:0000061 ! cementoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: CL:0000142
name: hyalocyte
namespace: cell
def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178]
synonym: "vitreous cell" RELATED []
xref: BTO:0004271
xref: FMA:70620
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000143
name: guidepost cell
namespace: cell
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000144
name: obsolete cell by function
namespace: cell
def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [FB:ma]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000145
name: professional antigen presenting cell
namespace: cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
synonym: "APC" BROAD []
is_a: CL:0000473 ! defensive cell
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: CL:0000146
name: simple columnar epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000147
name: pigment cell
namespace: cell
def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm]
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000148
name: melanocyte
namespace: cell
alt_id: CL:0000572
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl]
synonym: "melanophore" NARROW []
xref: BTO:0000847
xref: CALOHA:TS-0613
xref: FMA:70545
xref: VHOG:0001679
is_a: CL:0000147 {is_inferred="true"} ! pigment cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000147 ! pigment cell
intersection_of: develops_from CL:0000541 ! melanoblast
intersection_of: has_part GO:0042470 ! melanosome
relationship: develops_from CL:0000541 ! melanoblast
relationship: has_part GO:0042470 ! melanosome

[Term]
id: CL:0000149
name: visual pigment cell
namespace: cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000150
name: glandular epithelial cell
namespace: cell
def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm]
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002371 ! somatic cell
relationship: part_of UBERON:0006799 ! glandular epithelium

[Term]
id: CL:0000151
name: secretory cell
namespace: cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell

[Term]
id: CL:0000152
name: exocrine cell
namespace: cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002365 ! exocrine gland
relationship: part_of UBERON:0002365 ! exocrine gland

[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
namespace: cell
def: "A cell that secretes glycosaminoglycans." [GOC:tfm]
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell

[Term]
id: CL:0000154
name: protein secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0009306 ! protein secretion
relationship: capable_of GO:0009306 ! protein secretion

[Term]
id: CL:0000155
name: peptic cell
namespace: cell
def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm]
synonym: "chief cell of stomach" EXACT []
synonym: "gastric chief cell" EXACT []
synonym: "pepsinogen secreting cell" EXACT []
synonym: "zymogenic cell" EXACT []
xref: FMA:62902
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002659 ! glandular cell of stomach

[Term]
id: CL:0000156
name: obsolete antibody secreting cell
namespace: cell
def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." []
comment: Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000157
name: surfactant secreting cell
namespace: cell
def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000151 {is_inferred="true"} ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0043129 ! surfactant homeostasis
relationship: capable_of GO:0043129 ! surfactant homeostasis

[Term]
id: CL:0000158
name: Clara cell
namespace: cell
def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712]
synonym: "bronchiolar non-ciliated cell" EXACT []
synonym: "Clara cell of bronchiole" EXACT []
xref: BTO:0004811
xref: FMA:14119
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell
intersection_of: CL:0002328 ! bronchial epithelial cell
intersection_of: bearer_of PATO:0001789 ! domed
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: capable_of GO:0043129 ! surfactant homeostasis
intersection_of: has_plasma_membrane_part GO:0005902 ! microvillus
relationship: bearer_of PATO:0001789 ! domed
relationship: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0043129 ! surfactant homeostasis
relationship: has_plasma_membrane_part GO:0005902 ! microvillus

[Term]
id: CL:0000159
name: seromucus secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000160
name: goblet cell
namespace: cell
def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320]
synonym: "chalice cell" EXACT []
xref: BTO:0001540
xref: FMA:13148
xref: http://en.wikipedia.org/wiki/Goblet_cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell
relationship: capable_of GO:0070254 ! mucus secretion

[Term]
id: CL:0000161
name: acid secreting cell
namespace: cell
is_a: CL:0000151 {is_inferred="true"} ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0046717 ! acid secretion
relationship: capable_of GO:0046717 ! acid secretion

[Term]
id: CL:0000162
name: parietal cell
namespace: cell
def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651]
synonym: "oxyntic cell" EXACT []
xref: BTO:0001780
xref: FMA:62901
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0002659 ! glandular cell of stomach

[Term]
id: CL:0000163
name: endocrine cell
namespace: cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407]
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0060986 ! endocrine hormone secretion
relationship: capable_of GO:0060986 ! endocrine hormone secretion
relationship: part_of UBERON:0002368 ! endocrine gland

[Term]
id: CL:0000164
name: enteroendocrine cell
namespace: cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl]
xref: BTO:0003865
xref: FMA:62930
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000165
name: neuroendocrine cell
namespace: cell
def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688]
synonym: "neurosecretory cell" EXACT []
xref: BTO:0002691
xref: FMA:83810
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000166
name: chromaffin cell
namespace: cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161]
synonym: "phaeochromocyte" EXACT []
xref: BTO:0000259
xref: FMA:69263
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000167
name: peptide hormone secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030072 ! peptide hormone secretion
relationship: capable_of GO:0030072 ! peptide hormone secretion

[Term]
id: CL:0000168
name: insulin secreting cell
namespace: cell
xref: BTO:0000783
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030073 ! insulin secretion
relationship: capable_of GO:0030073 ! insulin secretion

[Term]
id: CL:0000169
name: type B pancreatic cell
namespace: cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651]
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.
synonym: "B-cell of pancreatic islet" EXACT [FMA:70586]
synonym: "beta cell" BROAD [ZFA:0009102]
synonym: "beta cell islet" RELATED [MA:0002419]
synonym: "beta cell of pancreatic islet" EXACT [FMA:70586]
synonym: "insulin-secreting cell" EXACT [FMA:70586]
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT [FMA:70586]
synonym: "pancreatic beta cell" EXACT [FMA:70586]
synonym: "pancreatic islet core" EXACT [MA:0002419]
synonym: "type B enteroendocrine cell" EXACT [FMA:70586]
xref: BTO:0000783
xref: EV:0200009
xref: FMA:70586
xref: MA:0002419
xref: ncithesaurus:Beta_Cell
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 {is_inferred="true"} ! enteroendocrine cell
is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0030073 ! insulin secretion
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: capable_of GO:0030073 ! insulin secretion
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans

[Term]
id: CL:0000170
name: glucagon secreting cell
namespace: cell
def: "A cell that secretes glucagon." [GOC:tfm]
synonym: "glucagon-secreting cell" EXACT []
xref: FMA:84045
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion

[Term]
id: CL:0000171
name: pancreatic A cell
namespace: cell
def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544]
synonym: "alpha cell of iselt of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
xref: BTO:0000990
xref: FMA:70585
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0002067 ! type A enterocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0002067 ! type A enterocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: capable_of GO:0070091 ! glucagon secretion
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0000172
name: somatostatin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070253 ! somatostatin secretion
relationship: capable_of GO:0070253 ! somatostatin secretion

[Term]
id: CL:0000173
name: pancreatic D cell
namespace: cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm]
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
xref: BTO:0000803
xref: FMA:70587
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0000174
name: steroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035929 ! steroid hormone secretion
relationship: capable_of GO:0035929 ! steroid hormone secretion

[Term]
id: CL:0000175
name: luteal cell
namespace: cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400]
synonym: "lutein cell" EXACT []
xref: BTO:0003939
xref: FMA:18688
is_a: CL:0000179 ! progesterone secreting cell
is_a: CL:0002132 ! stromal cell of ovary
relationship: capable_of GO:0042701 ! progesterone secretion
relationship: part_of UBERON:0002512 ! corpus luteum

[Term]
id: CL:0000176
name: ecdysteroid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0045457 ! ecdysteroid secretion
relationship: capable_of GO:0045457 ! ecdysteroid secretion

[Term]
id: CL:0000177
name: testosterone secreting cell
namespace: cell
is_a: CL:0000593 ! androgen secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035936 ! testosterone secretion
relationship: capable_of GO:0035936 ! testosterone secretion

[Term]
id: CL:0000178
name: Leydig cell
namespace: cell
def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120]
comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated
synonym: "interstitial cell" BROAD []
synonym: "interstitial cell of Leydig" EXACT []
xref: BTO:0000755
xref: CALOHA:TS-1150
xref: EMAPA:29655
xref: FMA:72297
is_a: CL:0000177 ! testosterone secreting cell
relationship: part_of UBERON:0005212 ! Leydig cell region of testis

[Term]
id: CL:0000179
name: progesterone secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0042701 ! progesterone secretion
relationship: capable_of GO:0042701 ! progesterone secretion

[Term]
id: CL:0000180
name: estradiol secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035938 ! estradiol secretion
relationship: capable_of GO:0035938 ! estradiol secretion

[Term]
id: CL:0000181
name: metabolising cell
namespace: cell
def: "A cell whose primary function is intermediary metabolism." [FB:ma]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000182
name: hepatocyte
namespace: cell
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280]
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000181 ! metabolising cell
is_a: CL:0000417 ! endopolyploid cell
is_a: CL:0002371 ! somatic cell
relationship: capable_of GO:0006699 ! bile acid biosynthetic process
relationship: capable_of GO:0044237 ! cellular metabolic process
relationship: capable_of GO:0098754 ! detoxification
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000183
name: contractile cell
namespace: cell
def: "A cell whose primary function is to shorten." [FB:ma]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000185
name: myoepithelial cell
namespace: cell
def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544]
synonym: "basket epithelial cell" EXACT []
synonym: "myoepitheliocyte" EXACT []
xref: BTO:0002309
xref: CALOHA:TS-2379
xref: FMA:67799
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000183 ! contractile cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000186
name: myofibroblast cell
namespace: cell
def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469]
comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.
synonym: "MFB" EXACT [PMID:8731193]
is_a: CL:0000183 ! contractile cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000187
name: muscle cell
namespace: cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620]
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000056 ! myoblast

[Term]
id: CL:0000188
name: cell of skeletal muscle
namespace: cell
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
synonym: "skeletal muscle cell" EXACT []
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000189
name: slow muscle cell
namespace: cell
def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908]
synonym: "slow muscle fiber" RELATED [ISBN:0815316208]
xref: FMA:84448
is_a: CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000857 ! slow muscle myoblast

[Term]
id: CL:0000190
name: fast muscle cell
namespace: cell
def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908]
synonym: "glycolytic muscle fiber" EXACT []
is_a: CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000858 ! fast muscle myoblast

[Term]
id: CL:0000192
name: smooth muscle cell
namespace: cell
alt_id: CL:0000191
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361]
synonym: "myocytes, smooth muscle" EXACT [MESH:D032389]
synonym: "non-striated muscle cell" NARROW []
synonym: "SMCs" EXACT [PMID:9315361]
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: develops_from CL:0000514 ! smooth muscle myoblast

[Term]
id: CL:0000193
name: cardiac muscle cell (sensu Arthopoda)
namespace: cell
alt_id: CL:0000466
def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [MESH:A11.620.500]
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: develops_from CL:0000465 ! cardioblast (sensu Arthropoda)
relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda)

[Term]
id: CL:0000194
name: obsolete nodal cardiac cell
namespace: cell
comment: Consider CL:0002072.
is_obsolete: true

[Term]
id: CL:0000195
name: obsolete Purkinje fiber
namespace: cell
is_obsolete: true

[Term]
id: CL:0000196
name: flight muscle cell
namespace: cell
is_a: CL:0008003 ! somatic muscle myotube
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0002478 ! transversely striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0000197
name: receptor cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000198
name: pain receptor cell
namespace: cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650]
comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship
synonym: "nociceptor" EXACT []
synonym: "nocireceptor" EXACT []
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000199
name: mechanoreceptor cell
namespace: cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500]
synonym: "mechanoreceptor" RELATED [MP:0000972]
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception

[Term]
id: CL:0000200
name: touch receptor cell
namespace: cell
is_a: CL:0000199 ! mechanoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
relationship: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch

[Term]
id: CL:0000202
name: auditory hair cell
namespace: cell
alt_id: CL:0000201
def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250]
comment: In mammals these cells are located in the organ of Corti.
synonym: "auditory receptor cell" EXACT []
synonym: "cochlear hair cell" EXACT []
synonym: "inner ear hair cell" RELATED [GO:0060119]
synonym: "inner ear receptor cell" RELATED [GO:0060119]
xref: FMA:62364
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002374 ! ear hair cell
is_a: CL:0002491 ! auditory epithelial cell
relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
relationship: part_of UBERON:0002227 ! spiral organ of cochlea

[Term]
id: CL:0000203
name: gravity sensitive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000199 ! mechanoreceptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: capable_of GO:0070999 ! detection of mechanical stimulus involved in sensory perception of gravity
relationship: capable_of GO:0070999 ! detection of mechanical stimulus involved in sensory perception of gravity

[Term]
id: CL:0000204
name: acceleration receptive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000205
name: thermoreceptor cell
namespace: cell
def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971]
is_a: CL:0000006 ! neuronal receptor cell
intersection_of: CL:0000006 ! neuronal receptor cell
intersection_of: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception
relationship: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception

[Term]
id: CL:0000206
name: chemoreceptor cell
namespace: cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120]
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception

[Term]
id: CL:0000207
name: olfactory receptor cell
namespace: cell
synonym: "odorant receptor cell" EXACT []
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
xref: BTO:0004185
xref: FMA:67860
xref: Wikipedia:Olfactory_receptor_neuron
is_a: CL:0000206 ! chemoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: part_of UBERON:0005725 ! olfactory system

[Term]
id: CL:0000208
name: pH receptor cell
namespace: cell
is_a: CL:0000206 ! chemoreceptor cell

[Term]
id: CL:0000209
name: taste receptor cell
namespace: cell
def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256]
synonym: "taste bud cell" EXACT []
xref: FMA:67910
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of UBERON:0002025 ! stratum basale of epidermis

[Term]
id: CL:0000210
name: photoreceptor cell
namespace: cell
def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650]
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FBbt:00004211
xref: FMA:86740
is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception

[Term]
id: CL:0000211
name: electrically active cell
namespace: cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000212
name: absorptive cell
namespace: cell
def: "A cell that takes up and metabolizes substances." [CL:CVS]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000213
name: lining cell
namespace: cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb]
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000214
name: synovial cell
namespace: cell
def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474]
synonym: "hyaluronic acid secreting cell" NARROW []
synonym: "synoviocyte" EXACT []
xref: BTO:0003652
xref: CALOHA:TS-0995
xref: FMA:66786
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint
relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint

[Term]
id: CL:0000215
name: barrier cell
namespace: cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000216
name: Sertoli cell
namespace: cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789]
xref: BTO:0001238
xref: CALOHA:TS-0922
xref: FMA:72298
xref: VHOG:0001348
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 {is_inferred="true"} ! supportive cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
intersection_of: CL:0000630 ! supportive cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis

[Term]
id: CL:0000217
name: insulating cell
namespace: cell
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000218
name: myelinating Schwann cell
namespace: cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800]
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
xref: CALOHA:TS-0898
xref: FMA:62121
is_a: CL:0000217 ! insulating cell
is_a: CL:0000328 ! myelin accumulating cell
is_a: CL:0002573 ! Schwann cell
relationship: develops_from CL:0002377 ! immature Schwann cell

[Term]
id: CL:0000219
name: motile cell
namespace: cell
def: "A cell that moves by its own activities." [FB:ma]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0048870 ! cell motility
relationship: capable_of GO:0048870 ! cell motility

[Term]
id: CL:0000220
name: obsolete cell by lineage
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000221
name: ectodermal cell
namespace: cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273]
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: CL:0000222
name: mesodermal cell
namespace: cell
def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660]
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000926 ! mesoderm

[Term]
id: CL:0000223
name: endodermal cell
namespace: cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407]
synonym: "endoderm cell" EXACT []
xref: FMA:72555
is_a: CL:0002321 ! embryonic cell
relationship: part_of UBERON:0000925 ! endoderm

[Term]
id: CL:0000224
name: obsolete cell by nuclear number
namespace: cell
def: "OBSOLETE: A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034

[Term]
id: CL:0000225
name: anucleate cell
namespace: cell
def: "A cell that lacks a nucleus." [FB:ma]
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001405 ! anucleate
disjoint_from: CL:0002242 ! nucleate cell
relationship: bearer_of PATO:0001405 ! anucleate

[Term]
id: CL:0000226
name: single nucleate cell
namespace: cell
def: "A cell with a single nucleus." [FB:ma, GOC:tfm]
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001407 ! mononucleate
relationship: bearer_of PATO:0001407 ! mononucleate

[Term]
id: CL:0000227
name: binucleate cell
namespace: cell
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001406 ! binucleate
relationship: bearer_of PATO:0001406 ! binucleate

[Term]
id: CL:0000228
name: multinucleate cell
namespace: cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
xref: AEO:0000203
xref: WBbt:0008074
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0001908 ! multinucleate

[Term]
id: CL:0000229
name: obsolete lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000230
name: obsolete T lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000231
name: obsolete B lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000232
name: erythrocyte
namespace: cell
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290]
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: bearer_of PATO:0002039 ! biconcave
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: capable_of GO:0015671 ! oxygen transport
intersection_of: lacks_part GO:0005840 ! ribosome
intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: bearer_of PATO:0002039 ! biconcave
relationship: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0015671 ! oxygen transport
relationship: develops_from CL:0000558 ! reticulocyte
relationship: lacks_part GO:0005840 ! ribosome
relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000233
name: platelet
namespace: cell
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831]
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.
synonym: "anucleate thrombocyte" EXACT []
synonym: "blood platelet" EXACT []
synonym: "enucleate thrombocyte" EXACT []
xref: BTO:0000132
xref: CALOHA:TS-0803
xref: FMA:62851
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
intersection_of: CL:0000763 ! myeloid cell
intersection_of: bearer_of PATO:0001405 ! anucleate
intersection_of: bearer_of PATO:0001874 ! discoid
intersection_of: capable_of GO:0007596 ! blood coagulation
intersection_of: capable_of GO:0008015 ! blood circulation
relationship: bearer_of PATO:0001405 ! anucleate
relationship: bearer_of PATO:0001874 ! discoid
relationship: capable_of GO:0007596 ! blood coagulation
relationship: capable_of GO:0008015 ! blood circulation
relationship: develops_from CL:0000556 ! megakaryocyte

[Term]
id: CL:0000234
name: phagocyte
namespace: cell
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
xref: BTO:0001044
xref: FMA:83806
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0006909 ! phagocytosis

[Term]
id: CL:0000235
name: macrophage
namespace: cell
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437]
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
synonym: "histiocyte" EXACT []
xref: BTO:0000801
xref: CALOHA:TS-0587
xref: FMA:63261
xref: FMA:83585
is_a: CL:0000234 ! phagocyte
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0031268 ! pseudopodium organization
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0031268 ! pseudopodium organization
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000236
name: B cell
namespace: cell
def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
xref: BTO:0000776
xref: CALOHA:TS-0068
xref: FMA:62869
xref: VHOG:0001480
is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: capable_of GO:0019724 ! B cell mediated immunity
relationship: capable_of GO:0019724 ! B cell mediated immunity
relationship: develops_from CL:0000826 ! pro-B cell

[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000238
name: non keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell

[Term]
id: CL:0000239
name: brush border epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000240
name: stratified squamous epithelial cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000241
name: stratified cuboidal epithelial cell
namespace: cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000242
name: Merkel cell
namespace: cell
def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425]
synonym: "Merkel's cell" EXACT []
xref: FMA:70548
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000312 {source="PMID:19782676"} ! keratinocyte
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: part_of UBERON:0002025 ! stratum basale of epidermis

[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A08.637]
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000244
name: transitional epithelial cell
namespace: cell
def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544]
xref: FMA:66778
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000245
name: obsolete passage cell
namespace: cell
def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208]
comment: replaced_by: PO:0000353
is_obsolete: true

[Term]
id: CL:0000246
name: Mauthner neuron
namespace: cell
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000247
name: Rohon-Beard neuron
namespace: cell
def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484]
synonym: "RB neuron" RELATED [VHOG:0001484]
synonym: "Rohon Beard cell" EXACT [VHOG:0001484]
synonym: "Rohon-Beard cell" EXACT []
xref: AAO:0010316
xref: EFO:0003711
xref: VHOG:0001484
is_a: CL:0000531 ! primary sensory neuron

[Term]
id: CL:0000248
name: obsolete microsporocyte
namespace: cell
def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208]
comment: replaced_by: PO:0020047
synonym: "pollen mother cell" EXACT []
synonym: "primary sporogenous cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000249
name: hatching gland cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000250
name: obsolete megaspore
namespace: cell
def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208]
comment: replaced_by: PO:0020019
is_obsolete: true

[Term]
id: CL:0000251
name: extramedullary cell
namespace: cell
is_a: CL:0000101 ! sensory neuron

[Term]
id: CL:0000252
name: obsolete microspore
namespace: cell
def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208]
comment: replaced_by: PO:0020048
is_obsolete: true

[Term]
id: CL:0000253
name: eurydendroid cell
namespace: cell
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000254
name: obsolete egg cell
namespace: cell
def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr]
comment: replaced_by: PO:0020094
synonym: "female gametophyte egg cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000255
name: eukaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell
disjoint_from: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000256
name: uric acid accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000257
name: Mycetozoan cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000258
name: obsolete fiber tracheid
namespace: cell
def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208]
comment: replaced_by: PO:0000355
is_obsolete: true

[Term]
id: CL:0000259
name: aggregate cell
namespace: cell
def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000260
name: obsolete mucilage cell
namespace: cell
def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208]
comment: replaced_by: PO:0000373
is_obsolete: true

[Term]
id: CL:0000261
name: anterior cell
namespace: cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000262
name: obsolete guard mother cell
namespace: cell
def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208]
comment: replaced_by: PO:0000351
is_obsolete: true

[Term]
id: CL:0000263
name: vegetative cell (sensu Mycetozoa)
namespace: cell
def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB]
synonym: "amoeba" EXACT []
is_a: CL:0000257 ! Mycetozoan cell

[Term]
id: CL:0000264
name: obsolete phloem initial
namespace: cell
def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208]
comment: replaced_by: PO:0000400
synonym: "phloem mother cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000265
name: anterior like cell
namespace: cell
def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB]
synonym: "ALC" EXACT []
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000266
name: obsolete meristemoid
namespace: cell
def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208]
comment: replaced_by: PO:0004011
is_obsolete: true

[Term]
id: CL:0000267
name: prespore cell
namespace: cell
def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000268
name: obsolete sieve element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208]
is_obsolete: true

[Term]
id: CL:0000269
name: prestalk cell
namespace: cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000270
name: obsolete subsidiary cell
namespace: cell
def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520]
comment: replaced_by: PO:0000284
is_obsolete: true

[Term]
id: CL:0000271
name: prestalk A cell
namespace: cell
def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstA" EXACT []
synonym: "pstAO" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000272
name: obsolete cambial initial
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208]
comment: replaced_by PO:0000295
is_obsolete: true

[Term]
id: CL:0000273
name: prestalk AB cell
namespace: cell
def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstAB" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000275
name: prestalk B cell
namespace: cell
def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB]
synonym: "pstB" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000276
name: obsolete sclerenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208]
comment: replaced_by: PO:0000077
is_obsolete: true

[Term]
id: CL:0000277
name: obsolete prestalk I cell
namespace: cell
def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB]
comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology.
is_obsolete: true
replaced_by: DDANAT:0000406

[Term]
id: CL:0000278
name: obsolete central cell
namespace: cell
def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr]
comment: replaced_by: PO:0020090
is_obsolete: true

[Term]
id: CL:0000279
name: prestalk 0 cell
namespace: cell
def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB]
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000280
name: obsolete generative cell
namespace: cell
def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr]
comment: replaced_by: PO:0020097
is_obsolete: true

[Term]
id: CL:0000281
name: pstAB/ALC
namespace: cell
def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell

[Term]
id: CL:0000282
name: obsolete trichome
namespace: cell
def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806]
comment: replaced_by: PO:0000282
is_obsolete: true

[Term]
id: CL:0000283
name: pstO/ALC
namespace: cell
def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell

[Term]
id: CL:0000284
name: obsolete companion cell
namespace: cell
def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322]
comment: replaced_by: PO:0000071
is_obsolete: true

[Term]
id: CL:0000285
name: stalk cell
namespace: cell
def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000286
name: hyphal cell
namespace: cell
def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X]
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000287
name: eye photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye

[Term]
id: CL:0000288
name: obsolete synergid
namespace: cell
def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208]
comment: replaced_by: PO:0000191
is_obsolete: true

[Term]
id: CL:0000289
name: chemotactic amoeboid cell (sensu Mycetozoa)
namespace: cell
def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
is_a: CL:0000732 ! amoeboid cell

[Term]
id: CL:0000290
name: obsolete xylem fiber cell
namespace: cell
def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208]
comment: replaced_by: PO:0000274
is_obsolete: true

[Term]
id: CL:0000291
name: spore (sensu Mycetozoa)
namespace: cell
def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436]
xref: DDANAT:0000414
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000292
name: obsolete guard cell
namespace: cell
def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208]
comment: replaced_by: PO:0000293
synonym: "stomatal guard cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000293
name: structural cell
namespace: cell
def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000294
name: obsolete sieve cell
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208]
is_obsolete: true

[Term]
id: CL:0000295
name: somatotropin secreting cell
namespace: cell
alt_id: CL:0000471
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl]
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030252 ! growth hormone secretion
relationship: capable_of GO:0030252 ! growth hormone secretion

[Term]
id: CL:0000296
name: obsolete vegetative cell
namespace: cell
def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr]
comment: replaced_by: PO:0020099
is_obsolete: true

[Term]
id: CL:0000297
name: obsolete socket cell
namespace: cell
def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806]
comment: replaced_by: PO:0000115
is_obsolete: true

[Term]
id: CL:0000298
name: obsolete xylem element
namespace: cell
def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208]
comment: replaced_by: PO:0000273
is_obsolete: true

[Term]
id: CL:0000299
name: obsolete trichoblast
namespace: cell
def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208]
comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262).
is_obsolete: true

[Term]
id: CL:0000300
name: gamete
namespace: cell
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544]
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FBbt:00005412
xref: FMA:18649
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: bearer_of PATO:0001375 ! haploid
intersection_of: capable_of GO:0009566 ! fertilization
relationship: bearer_of PATO:0001375 ! haploid
relationship: capable_of GO:0009566 ! fertilization

[Term]
id: CL:0000301
name: pole cell
namespace: cell
xref: FBbt:00000092
is_a: CL:0000670 ! primordial germ cell

[Term]
id: CL:0000302
name: obsolete IgM B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000303
name: obsolete IgG B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000304
name: obsolete IgA B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000305
name: obsolete IgE B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000306
name: crystallin accumulating cell
namespace: cell
synonym: "lens cell" EXACT []
xref: FBbt:00004193
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000307
name: tracheal epithelial cell
namespace: cell
alt_id: CL:1000474
def: "An epithelial cell found in the trachea." [GOC:tfm]
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from CL:0000377 ! tracheoblast
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: CL:0000308
name: metal ion accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000309
name: copper accumulating cell
namespace: cell
synonym: "cuprophilic cell" EXACT []
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000310
name: iron accumulating cell
namespace: cell
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000311
name: keratin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000312
name: keratinocyte
namespace: cell
alt_id: CL:0002185
def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116]
comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
synonym: "keratinized cell of epidermis" EXACT []
synonym: "malpighian cell" EXACT []
xref: BTO:0000667
xref: CALOHA:TS-0500
xref: FMA:62879
is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell
is_a: CL:0000362 {is_inferred="true"} ! epidermal cell
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: capable_of GO:0002775 ! antimicrobial peptide production
relationship: capable_of GO:0002776 ! antimicrobial peptide secretion
relationship: capable_of GO:0090023 ! positive regulation of neutrophil chemotaxis
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: CL:0000313
name: serous secreting cell
namespace: cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000314
name: milk secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000315
name: tears secreting cell
namespace: cell
def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A12.200.882]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000316
name: obsolete ray initial
namespace: cell
def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208]
comment: replaced_by: PO:0000082
is_obsolete: true

[Term]
id: CL:0000317
name: sebum secreting cell
namespace: cell
def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702]
synonym: "sebocyte" EXACT []
is_a: CL:0000152 ! exocrine cell
is_a: CL:2000021 ! sebaceous gland native cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0001821 ! sebaceous gland

[Term]
id: CL:0000318
name: sweat secreting cell
namespace: cell
def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A12.200.849]
is_a: CL:0000150 ! glandular epithelial cell

[Term]
id: CL:0000319
name: mucus secreting cell
namespace: cell
synonym: "mucous cell" EXACT []
xref: BTO:0003689
is_a: CL:0000159 ! seromucus secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070254 ! mucus secretion
relationship: capable_of GO:0070254 ! mucus secretion

[Term]
id: CL:0000320
name: obsolete megasporocyte
namespace: cell
def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208]
comment: replaced_by: PO:0000431
synonym: "archesporial cell" EXACT []
synonym: "megaspore mother cell" EXACT []
is_obsolete: true

[Term]
id: CL:0000321
name: seminal fluid secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000322
name: pneumocyte
namespace: cell
def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144]
synonym: "alveolar epithelial cell" EXACT []
synonym: "pneumonocyte" EXACT []
xref: BTO:0000395
xref: CALOHA:TS-2168
xref: FMA:62499
is_a: CL:0010003 ! epithelial cell of alveolus of lung
relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium

[Term]
id: CL:0000323
name: lysozyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000324
name: metanephric mesenchyme stem cell
namespace: cell
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000325
name: stuff accumulating cell
namespace: cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
subset: ubprop:upper_level
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000326
name: glycogen accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: CL:0000328
name: myelin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000329
name: oxygen accumulating cell
namespace: cell
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0015671 ! oxygen transport
relationship: capable_of GO:0015671 ! oxygen transport

[Term]
id: CL:0000330
name: obsolete collenchymal cell
namespace: cell
def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208]
comment: replaced_by: PO:0000075
is_obsolete: true

[Term]
id: CL:0000331
name: obsolete tracheid
namespace: cell
def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208]
comment: replaced_by: PO:0000301
is_obsolete: true

[Term]
id: CL:0000332
name: obsolete atrichoblast
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819]
comment: replaced_by: PO:0020090
synonym: "non-hair cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000333
name: migratory neural crest cell
namespace: cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600]
xref: FMA:86667
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
relationship: develops_from CL:0007004 ! premigratory neural crest cell

[Term]
id: CL:0000334
name: vegetative cell (sensu Fungi)
namespace: cell
synonym: "yeast-form" RELATED []
xref: BTO:0002307
xref: FAO:0000032
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
namespace: cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
is_a: CL:0008019 ! mesenchymal cell

[Term]
id: CL:0000336
name: adrenal medulla chromaffin cell
namespace: cell
alt_id: CL:1000422
def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland]
synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262]
xref: FMA:69262
is_a: CL:0000457 ! biogenic amine secreting cell
is_a: CL:1000426 ! chromaffin cell of adrenal gland
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: develops_from CL:0000011 ! migratory trunk neural crest cell
relationship: part_of UBERON:0001236 ! adrenal medulla

[Term]
id: CL:0000337
name: neuroblast (sensu Vertebrata)
namespace: cell
def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563]
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000338
name: neuroblast (sensu Nematoda and Protostomia)
namespace: cell
synonym: "neuroblast" BROAD []
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
namespace: cell
def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256]
synonym: "spongioblast" EXACT []
xref: FMA:70564
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)

[Term]
id: CL:0000340
name: glioblast (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000030 ! glioblast
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000341
name: pigment cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000342
name: pigment cell (sensu Vertebrata)
namespace: cell
def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000343
name: visual pigment cell (sensu Vertebrata)
namespace: cell
def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm]
xref: FMA:63846
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata)
intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata)
intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception
relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception

[Term]
id: CL:0000344
name: obsolete non-visual cell (sensu Vertebrata)
namespace: cell
is_obsolete: true

[Term]
id: CL:0000345
name: dental papilla cell
namespace: cell
def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544]
comment: Merge with odontoblast?
is_a: CL:0008019 ! mesenchymal cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001763 ! odontogenic papilla

[Term]
id: CL:0000346
name: hair follicle dermal papilla cell
namespace: cell
def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172]
comment: Are these really all stem cells?
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0000412 ! dermal papilla
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: part_of UBERON:0000412 ! dermal papilla

[Term]
id: CL:0000347
name: scleral cell
namespace: cell
def: "A cell of the sclera of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001773 ! sclera
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: CL:0000348
name: choroidal cell of the eye
namespace: cell
def: "A cell of the choroid of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001776 ! optic choroid

[Term]
id: CL:0000349
name: extraembryonic cell
namespace: cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0000478 ! extraembryonic structure

[Term]
id: CL:0000350
name: amnioserosal cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0010302 ! amnioserosa
relationship: part_of UBERON:0010302 ! amnioserosa

[Term]
id: CL:0000351
name: trophoblast cell
namespace: cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936]
synonym: "trophoblastic cell" EXACT []
xref: FMA:83028
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0000358 ! blastocyst
relationship: part_of UBERON:0000358 ! blastocyst

[Term]
id: CL:0000352
name: epiblast cell
namespace: cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256]
is_a: CL:0000052 ! totipotent stem cell

[Term]
id: CL:0000353
name: blastoderm cell
namespace: cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104]
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
is_a: CL:0000007 ! early embryonic cell

[Term]
id: CL:0000354
name: blastemal cell
namespace: cell
synonym: "blastema cell" EXACT []
xref: ncithesaurus:Blastemal_Cell
is_a: CL:0000048 ! multi fate stem cell

[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
namespace: cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570]
comment: Multi-potency demonstrated ex vivo.  At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
xref: FMA:86767
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000356
name: hair matrix stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell

[Term]
id: CL:0000357
name: stratified epithelial stem cell
namespace: cell
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004590 ! sphincter muscle
relationship: part_of UBERON:0004590 ! sphincter muscle

[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell assocatiated with the vasculature." [GOC:dsd, GOC:tfm]
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002049 ! vasculature
relationship: part_of UBERON:0002049 ! vasculature

[Term]
id: CL:0000360
name: morula cell
namespace: cell
def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A16.254.270.550]
is_a: CL:0000007 ! early embryonic cell
relationship: part_of UBERON:0000085 ! morula

[Term]
id: CL:0000361
name: gastrula cell
namespace: cell
def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A16.254.412]
is_a: CL:0000007 ! early embryonic cell
relationship: part_of UBERON:0004734 ! gastrula

[Term]
id: CL:0000362
name: epidermal cell
namespace: cell
alt_id: CL:1000396
def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma]
synonym: "cell of epidermis" EXACT [FMA:62411]
synonym: "epithelial cell of skin" NARROW [FMA:62411]
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007376 ! outer epithelium
relationship: part_of UBERON:0007376 ! outer epithelium

[Term]
id: CL:0000363
name: obsolete axial cell
namespace: cell
def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208]
comment: replaced_by: PO:0000081
is_obsolete: true

[Term]
id: CL:0000364
name: obsolete ray cell
namespace: cell
def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208]
is_obsolete: true

[Term]
id: CL:0000365
name: animal zygote
namespace: cell
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
synonym: "zygote" BROAD []
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell

[Term]
id: CL:0000366
name: obsolete sperm cell (sensu Viridiplantae)
namespace: cell
def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208]
comment: replaced_by: PO:0000084
synonym: "gametophyte sperm cell" RELATED []
synonym: "male gametophyte sperm cell" RELATED []
synonym: "pollen germ cell " RELATED []
is_obsolete: true

[Term]
id: CL:0000367
name: sheath cell (sensu Nematoda)
namespace: cell
synonym: "glial cell (sensu Nematoda)" RELATED []
is_a: CL:0000619 ! support cell (sensu Nematoda)

[Term]
id: CL:0000368
name: obsolete myrosin cell
namespace: cell
def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208]
comment: replaced_by: PO:0000352
is_obsolete: true

[Term]
id: CL:0000370
name: obsolete transfer cell
namespace: cell
def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208]
comment: replaced_by: PO:0000078
synonym: "intermediary cell" RELATED []
is_obsolete: true

[Term]
id: CL:0000371
name: protoplast
namespace: cell
def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X]
is_a: CL:0000578 ! experimentally modified cell in vitro

[Term]
id: CL:0000372
name: tormogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253]
synonym: "socket cell" BROAD [ISBN:978-0801481253]
xref: FBbt:00005171
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)

[Term]
id: CL:0000373
name: histoblast
namespace: cell
xref: FBbt:00001789
is_a: CL:0000146 ! simple columnar epithelial cell

[Term]
id: CL:0000374
name: trichogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253]
synonym: "hair cell" BROAD []
xref: BTO:0004744
xref: FBbt:00005169
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)

[Term]
id: CL:0000375
name: obsolete osteoprogenitor cell
namespace: cell
xref: BTO:0002051
is_obsolete: true
replaced_by: CL:0007010

[Term]
id: CL:0000376
name: humidity receptor cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:0000377
name: tracheoblast
namespace: cell
is_a: CL:0000069 ! branched duct epithelial cell

[Term]
id: CL:0000378
name: support cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000379
name: sensory processing neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000380
name: thecogen cell
namespace: cell
def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173]
synonym: "fly sheath cell" EXACT []
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000381
name: neurosecretory neuron
namespace: cell
xref: FBbt:00005130
is_a: CL:0000151 ! secretory cell
is_a: CL:0000527 ! efferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0046879 ! hormone secretion
relationship: capable_of GO:0046879 ! hormone secretion

[Term]
id: CL:0000382
name: scolopale cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000383
name: nephrogenic mesenchyme stem cell
namespace: cell
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000384
name: ligament cell
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005062
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000386
name: attachment cell
namespace: cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000387
name: hemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005063
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
relationship: capable_of GO:0035010 {source="PMID:18025161"} ! encapsulation of foreign target
relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000388
name: tendon cell
namespace: cell
def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:957445]
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
is_a: CL:0000135 {is_inferred="true"} ! fibrocyte
is_a: CL:0000386 ! attachment cell
intersection_of: CL:0000135 ! fibrocyte
intersection_of: part_of UBERON:0000043 ! tendon
relationship: part_of UBERON:0000043 ! tendon

[Term]
id: CL:0000389
name: socket cell (sensu Nematoda)
namespace: cell
is_a: CL:0000619 ! support cell (sensu Nematoda)
is_a: CL:0000658 ! cuticle secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000081 ! blood cell

[Term]
id: CL:0000391
name: podocyte (sensu Diptera)
namespace: cell
def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778]
xref: FBbt:00001688
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
relationship: develops_from CL:0000394 ! plasmatocyte

[Term]
id: CL:0000392
name: crystal cell
namespace: cell
xref: FMA:63847
is_a: CL:0000391 ! podocyte (sensu Diptera)

[Term]
id: CL:0000393
name: electrically responsive cell
namespace: cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000394
name: plasmatocyte
namespace: cell
xref: FBbt:00001685
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000395
name: procrystal cell
namespace: cell
xref: FBbt:00001689
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000396
name: lamellocyte
namespace: cell
xref: FBbt:00001687
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000397
name: ganglion interneuron
namespace: cell
is_a: CL:0000099 {is_inferred="true"} ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0000045 ! ganglion
relationship: part_of UBERON:0000045 ! ganglion

[Term]
id: CL:0000398
name: polygonal cell
namespace: cell
xref: FBbt:00001691
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000399
name: obsolete phloem element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm]
is_obsolete: true

[Term]
id: CL:0000400
name: obsolete pavement cell
namespace: cell
def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289]
comment: replaced_by: PO:0000332
is_obsolete: true

[Term]
id: CL:0000401
name: macrophage (sensu Diptera)
namespace: cell
xref: FBbt:00001686
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000402
name: CNS interneuron
namespace: cell
is_a: CL:0000099 {is_inferred="true"} ! interneuron
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000404
name: electrically signaling cell
namespace: cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000405
name: neuroepidermoblast
namespace: cell
xref: FBbt:00005148
is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000406
name: CNS short range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000407
name: scolopidial ligament cell
namespace: cell
xref: FBbt:00005221
is_a: CL:0000384 ! ligament cell

[Term]
id: CL:0000408
name: male gamete
namespace: cell
xref: BTO:0001277
xref: CALOHA:TS-0949
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000300 {is_inferred="true"} ! gamete
intersection_of: CL:0000015 ! male germ cell
intersection_of: bearer_of PATO:0001375 ! haploid
intersection_of: capable_of GO:0009566 ! fertilization
relationship: bearer_of PATO:0001375 ! haploid
relationship: capable_of GO:0009566 ! fertilization

[Term]
id: CL:0000409
name: scolopidial sheath cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000618 ! sheath cell

[Term]
id: CL:0000410
name: CNS long range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000411
name: flatworm hypodermal cell
namespace: cell
def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm]
xref: WBbt:0007846
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000412
name: polyploid cell
namespace: cell
def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000413
name: haploid cell
namespace: cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: bearer_of PATO:0001375 ! haploid
relationship: bearer_of PATO:0001375 ! haploid

[Term]
id: CL:0000414
name: obsolete cell by ploidy
namespace: cell
def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0000255
consider: CL:0001034

[Term]
id: CL:0000415
name: diploid cell
namespace: cell
def: "A cell whose nucleus has two haploid genomes." [FB:ma]
xref: FMA:72300
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000416
name: polytene cell
namespace: cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000417
name: endopolyploid cell
namespace: cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000418
name: arcade cell
namespace: cell
def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells]
xref: WBbt:0005793
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000419
name: seam cell
namespace: cell
def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm]
xref: BTO:0003039
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000420
name: syncytial epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000421
name: coelomocyte
namespace: cell
def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544]
xref: BTO:0002856
xref: WBbt:0005751
is_a: CL:0000080 ! circulating cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000422
name: mitogenic signaling cell
namespace: cell
def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000423
name: tip cell
namespace: cell
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000424
name: excretory cell
namespace: cell
def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135]
xref: WBbt:0005812
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000425
name: pore cell
namespace: cell
def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb]
is_a: CL:0000658 ! cuticle secreting cell

[Term]
id: CL:0000426
name: scaffold cell
namespace: cell
is_a: CL:0000445 ! apoptosis fated cell

[Term]
id: CL:0000427
name: GLR cell
namespace: cell
def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm]
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000428
name: yolk cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000349 ! extraembryonic cell

[Term]
id: CL:0000429
name: imaginal disc cell
namespace: cell
is_a: CL:0000146 ! simple columnar epithelial cell

[Term]
id: CL:0000430
name: xanthophore cell
namespace: cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl]
synonym: "xanthophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005002 ! xanthoblast

[Term]
id: CL:0000431
name: iridophore
namespace: cell
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl]
synonym: "guanophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005001 ! iridoblast

[Term]
id: CL:0000432
name: reticular cell
namespace: cell
def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651]
synonym: "reticulum cell" EXACT []
xref: FMA:62877
is_a: CL:0000057 ! fibroblast

[Term]
id: CL:0000433
name: obsolete functional megaspore
namespace: cell
def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr]
comment: replaced_by: PO:0000244
is_obsolete: true

[Term]
id: CL:0000434
name: eccrine cell
namespace: cell
def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684]
is_a: CL:0000150 ! glandular epithelial cell

[Term]
id: CL:0000435
name: alkali secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000436
name: vaginal lubricant secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: CL:0000437
name: gonadtroph
namespace: cell
def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651]
synonym: "delta basophil" EXACT []
synonym: "follicle stimulating hormone secreting cell" EXACT []
synonym: "gonadotrope" EXACT []
synonym: "gonadotrope cell" EXACT []
synonym: "gonadotroph" EXACT []
synonym: "gonadotropic cell" EXACT []
synonym: "pituitary delta cell" EXACT []
xref: BTO:0002482
xref: FMA:83100
is_a: CL:0000438 ! luteinizing hormone secreting cell
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis

[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm]
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0032275 ! luteinizing hormone secretion
relationship: capable_of GO:0032275 ! luteinizing hormone secretion

[Term]
id: CL:0000439
name: prolactin secreting cell
namespace: cell
def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl]
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070459 ! prolactin secretion
relationship: capable_of GO:0070459 ! prolactin secretion

[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
namespace: cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl]
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
xref: BTO:0002277
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion
relationship: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion

[Term]
id: CL:0000441
name: follicle stem cell
namespace: cell
xref: FBbt:00004903
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000442
name: follicular dendritic cell
namespace: cell
def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252]
comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451.
xref: BTO:0004267
xref: FMA:83037
is_a: CL:0000473 ! defensive cell

[Term]
id: CL:0000443
name: calcitonin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036161 ! calcitonin secretion
relationship: capable_of GO:0036161 ! calcitonin secretion

[Term]
id: CL:0000444
name: obliquely striated muscle cell
namespace: cell
def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463]
comment: Examples include the somatic muscles of nemotodes and cephalopods.
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: bearer_of PATO:0002479 ! obliquely striated
intersection_of: has_part GO:0030017 ! sarcomere
relationship: bearer_of PATO:0002479 ! obliquely striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0000445
name: apoptosis fated cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000446
name: chief cell of parathyroid gland
namespace: cell
def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651]
synonym: "parathyroid chief cell" EXACT []
synonym: "parathyroid gland chief cell" EXACT []
synonym: "parathyroid hormone secreting cell" EXACT []
synonym: "principal cell of parathyroid gland" EXACT []
xref: BTO:0004712
xref: CALOHA:TS-2140
xref: FMA:69078
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0002260 ! epithelial cell of parathyroid gland

[Term]
id: CL:0000447
name: carbohydrate secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000448
name: white fat cell
namespace: cell
def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500]
synonym: "white adipocyte" RELATED []
synonym: "white adipose cell" EXACT []
synonym: "white fat cell" EXACT []
xref: CALOHA:TS-1119
xref: FMA:83434
is_a: CL:0000136 ! fat cell
relationship: develops_from CL:0002334 ! preadipocyte
relationship: part_of UBERON:0001347 ! white adipose tissue

[Term]
id: CL:0000449
name: brown fat cell
namespace: cell
def: "A cell from the thermogenic form of adipose tissue found in many species,  particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322]
synonym: "brown adipocyte" EXACT []
synonym: "brown adipose cell" EXACT []
xref: CALOHA:TS-0099
xref: FMA:83435
is_a: CL:0000136 ! fat cell
relationship: develops_from CL:0002335 ! brown preadipocyte
relationship: part_of UBERON:0001348 ! brown adipose tissue

[Term]
id: CL:0000451
name: dendritic cell
namespace: cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149]
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: capable_of GO:0045580 ! regulation of T cell differentiation
intersection_of: has_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
disjoint_from: CL:0000542 ! lymphocyte
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: capable_of GO:0045580 ! regulation of T cell differentiation
relationship: has_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000452
name: thyroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000453
name: Langerhans cell
namespace: cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
synonym: "Langerhans' cell" EXACT []
synonym: "LC" EXACT []
xref: BTO:0000705
xref: CALOHA:TS-2375
xref: FMA:63072
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: capable_of GO:0002828 ! regulation of type 2 immune response
intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K
relationship: capable_of GO:0002828 ! regulation of type 2 immune response
relationship: develops_from CL:0000763 ! myeloid cell
relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K

[Term]
id: CL:0000454
name: epinephrine secreting cell
namespace: cell
def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093]
synonym: "adrenaline secreting cell" EXACT [GO:0048242]
synonym: "epinephrin secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048242 ! epinephrine secretion
relationship: capable_of GO:0048242 ! epinephrine secretion

[Term]
id: CL:0000455
name: obsolete starch sheath cell
namespace: cell
def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520]
comment: replaced_by: PO:0004531
is_obsolete: true

[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion
relationship: capable_of GO:0035931 ! mineralocorticoid secretion

[Term]
id: CL:0000457
name: biogenic amine secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000458
name: serotonin secreting cell
namespace: cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576]
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001820 ! serotonin secretion
relationship: capable_of GO:0001820 ! serotonin secretion

[Term]
id: CL:0000459
name: noradrenergic cell
namespace: cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X]
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
relationship: capable_of GO:0048243 ! norepinephrine secretion

[Term]
id: CL:0000460
name: glucocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035933 ! glucocorticoid secretion
relationship: capable_of GO:0035933 ! glucocorticoid secretion

[Term]
id: CL:0000462
name: adepithelial cell
namespace: cell
xref: FBbt:00003219
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000463
name: epidermal cell (sensu arthropoda)
namespace: cell
def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253]
comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ.
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000464 ! epidermoblast

[Term]
id: CL:0000464
name: epidermoblast
namespace: cell
def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311]
xref: FBbt:00004994
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000465
name: cardioblast (sensu Arthropoda)
namespace: cell
xref: FBbt:00001666
is_a: CL:0010021 ! cardiac myoblast

[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
namespace: cell
alt_id: CL:0000640
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl]
synonym: "ACTH secreting cell" EXACT [GO:0051458]
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT [GO:0051458]
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0051458 ! corticotropin secretion
relationship: capable_of GO:0051458 ! corticotropin secretion

[Term]
id: CL:0000468
name: neuroglioblast
namespace: cell
xref: FBbt:00005147
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000469
name: ganglion mother cell
namespace: cell
xref: FBbt:00005149
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000470
name: digestive enzyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000472
name: obsolete chlorenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208]
comment: replaced_by: PO:0000076
is_obsolete: true

[Term]
id: CL:0000473
name: defensive cell
namespace: cell
def: "A cell whose primary function is to protect the organism." [JB:jb]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000474
name: pericardial nephrocyte
namespace: cell
def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135]
synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320]
xref: FBbt:00005058
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte

[Term]
id: CL:0000475
name: obsolete degenerate megaspore
namespace: cell
def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr]
comment: replaced_by: PO:0000245
is_obsolete: true

[Term]
id: CL:0000476
name: thyrotroph
namespace: cell
def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl]
synonym: "beta-basophil" EXACT []
synonym: "thyroid stimulating hormone secreting cell" EXACT []
synonym: "thyrotrope" EXACT []
xref: FMA:83099
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
relationship: capable_of GO:0070460 ! thyroid-stimulating hormone secretion

[Term]
id: CL:0000477
name: follicle cell
namespace: cell
comment: Editors note: check this. Currently used in goxp
synonym: "ovarian follicle cell" EXACT [GO:0007297]
xref: FBbt:00004904
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000441 ! follicle stem cell

[Term]
id: CL:0000478
name: oxytocin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000479
name: vasopressin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000480
name: secretin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000481
name: cholecystokin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000482
name: juvenile hormone secreting cell
namespace: cell
def: "An endocrine cell that secretes juvenile hormone." [GO:tfm]
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0045443 ! juvenile hormone secretion
relationship: capable_of GO:0045443 ! juvenile hormone secretion

[Term]
id: CL:0000483
name: bombesin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000484
name: connective tissue type mast cell
namespace: cell
def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811]
comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(TC)" EXACT []
synonym: "MCTC" EXACT []
synonym: "TC mast cells" EXACT []
is_a: CL:0000097 {is_inferred="true"} ! mast cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000097 ! mast cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0002384 ! connective tissue

[Term]
id: CL:0000485
name: mucosal type mast cell
namespace: cell
def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811]
comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(T)" EXACT []
synonym: "MCT" EXACT []
synonym: "T mast cells" EXACT []
is_a: CL:0000097 {is_inferred="true"} ! mast cell
intersection_of: CL:0000097 ! mast cell
intersection_of: capable_of GO:0002540 ! leukotriene production involved in inflammatory response
intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue
relationship: capable_of GO:0002540 ! leukotriene production involved in inflammatory response
relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue

[Term]
id: CL:0000486
name: garland cell
namespace: cell
def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135]
synonym: "garland nephrocyte" BROAD [GO:0061321]
xref: BTO:0004596
xref: FBbt:00005059
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte

[Term]
id: CL:0000487
name: oenocyte
namespace: cell
def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397]
xref: FBbt:00004995
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000488
name: visible light photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects visible light." [GOC:tfm]
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009584 ! detection of visible light
relationship: capable_of GO:0009584 ! detection of visible light

[Term]
id: CL:0000489
name: scotopic photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000490
name: photopic photoreceptor cell
namespace: cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000491
name: obsolete cytotoxic T cell
namespace: cell
def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." []
comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation.
is_obsolete: true

[Term]
id: CL:0000492
name: CD4-positive helper T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400]
synonym: "CD4-positive helper T lymphocyte" EXACT []
synonym: "CD4-positive helper T-cell" EXACT []
synonym: "CD4-positive helper T-lymphocyte" EXACT []
synonym: "CD4-positive T-helper cell" EXACT []
xref: CALOHA:TS-1146
xref: FMA:70572
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0001816 ! cytokine production
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_completed GO:0030217 ! T cell differentiation

[Term]
id: CL:0000493
name: obsolete regulatory T cell
namespace: cell
def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." []
comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead.
is_obsolete: true

[Term]
id: CL:0000494
name: UV sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm]
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009589 ! detection of UV
relationship: capable_of GO:0009589 ! detection of UV

[Term]
id: CL:0000495
name: blue sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000496
name: green sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to green light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000497
name: red sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to red light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000498
name: inhibitory interneuron
namespace: cell
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron]
xref: FMA:84776
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000499
name: stromal cell
namespace: cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830]
xref: BTO:0002064
xref: FMA:83624
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000500
name: follicular epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000501
name: granulosa cell
namespace: cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200]
synonym: "granulosa cell of ovary" EXACT []
xref: BTO:0000542
xref: CALOHA:TS-0729
xref: FMA:18718
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary

[Term]
id: CL:0000502
name: type D enteroendocrine cell
namespace: cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175]
synonym: "D cell" EXACT []
xref: FMA:62935
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell
relationship: capable_of GO:0070253 ! somatostatin secretion

[Term]
id: CL:0000503
name: theca cell
namespace: cell
def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400]
xref: BTO:0002850
xref: FMA:18690
is_a: CL:0000499 ! stromal cell
is_a: CL:0000593 ! androgen secreting cell

[Term]
id: CL:0000504
name: enterochromaffin-like cell
namespace: cell
def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A06.224.365]
comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell.
synonym: "ECL" EXACT []
xref: BTO:0002692
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002274 ! histamine secreting cell

[Term]
id: CL:0000505
name: substance P secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000506
name: enkephalin secreting cell
namespace: cell
def: "An endorphine cell that secretes enkephalin." [GO:tfm]
is_a: CL:0000507 ! endorphin secreting cell

[Term]
id: CL:0000507
name: endorphin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000508
name: type G enteroendocrine cell
namespace: cell
def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300]
synonym: "G cell " EXACT []
xref: BTO:0004108
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0000509 ! gastrin secreting cell
is_a: CL:0002180 ! mucous cell of stomach
relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum

[Term]
id: CL:0000509
name: gastrin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000510
name: paneth cell
namespace: cell
def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700]
xref: BTO:0000993
xref: FMA:62897
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0000323 ! lysozyme secreting cell
is_a: CL:0002563 ! intestinal epithelial cell
relationship: part_of UBERON:0001277 ! intestinal epithelium

[Term]
id: CL:0000511
name: androgen binding protein secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm]
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000512
name: paracrine cell
namespace: cell
def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000513
name: cardiac muscle myoblast
namespace: cell
alt_id: CL:0000714
def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470]
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
xref: FMA:84797
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue
relationship: develops_into CL:0000746 ! cardiac muscle cell
relationship: part_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: CL:0000514
name: smooth muscle myoblast
namespace: cell
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390]
synonym: "myoblast, smooth muscle" EXACT [MESH:D032390]
synonym: "satellite cell" RELATED []
xref: FMA:84798
is_a: CL:0000056 {is_inferred="true"} ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000192 ! smooth muscle cell
relationship: develops_into CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000515
name: skeletal muscle myoblast
namespace: cell
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
is_a: CL:0000056 {is_inferred="true"} ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell
relationship: develops_into CL:0008002 ! skeletal muscle fiber

[Term]
id: CL:0000516
name: perineuronal satellite cell
namespace: cell
def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A08.340.685]
synonym: "perineural satellite cell" EXACT []
synonym: "perineuronal satellite oligodendroglial cell" EXACT []
synonym: "satellite oligodendrocyte" EXACT []
xref: FMA:54550
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000517
name: macrophage derived foam cell
namespace: cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546]
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000235 ! macrophage

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
namespace: cell
def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm]
is_a: CL:0000234 ! phagocyte

[Term]
id: CL:0000519
name: phagocyte (sensu Nematoda and Protostomia)
namespace: cell
def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm]
is_a: CL:0000234 ! phagocyte

[Term]
id: CL:0000520
name: prokaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000521
name: fungal cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000548 ! animal cell

[Term]
id: CL:0000522
name: obsolete spore
namespace: cell
def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X]
is_obsolete: true

[Term]
id: CL:0000523
name: mononuclear cytotrophoblast cell
namespace: cell
def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908]
synonym: "Langhans' cell" EXACT []
xref: FMA:83042
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000524
name: spheroplast
namespace: cell
def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A11.868]
synonym: "sphaeroplast" EXACT []
is_a: CL:0000371 ! protoplast

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
namespace: cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
synonym: "plasmidotrophoblast" EXACT []
synonym: "syncytial trophoblast" EXACT []
synonym: "syntrophoblast" EXACT []
xref: FMA:83043
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000526
name: afferent neuron
namespace: cell
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650]
synonym: "input neuron" EXACT []
xref: FMA:87653
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000527
name: efferent neuron
namespace: cell
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655]
synonym: "output neuron" EXACT []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000528
name: nitrergic neuron
namespace: cell
def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A08.663.748]
xref: FMA:84792
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000529
name: pigmented epithelial cell
namespace: cell
is_a: CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000530
name: primary neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000531
name: primary sensory neuron
namespace: cell
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000530 ! primary neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: CL:0000530 ! primary neuron

[Term]
id: CL:0000532
name: CAP motoneuron
namespace: cell
is_a: CL:0000533 ! primary motor neuron

[Term]
id: CL:0000533
name: primary motor neuron
namespace: cell
xref: FMA:83619
is_a: CL:0000100 ! motor neuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000534
name: primary interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000535
name: secondary neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000536
name: secondary motor neuron
namespace: cell
xref: FMA:83620
is_a: CL:0000100 ! motor neuron
is_a: CL:0000535 ! secondary neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: CL:0000535 ! secondary neuron

[Term]
id: CL:0000537
name: obsolete antipodal cell
namespace: cell
def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208]
comment: replaced_by: PO:0020093
is_obsolete: true

[Term]
id: CL:0000538
name: obsolete epidermal initial
namespace: cell
def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr]
comment: replaced_by: PO:0000349
is_obsolete: true

[Term]
id: CL:0000539
name: obsolete idioblast
namespace: cell
def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208]
is_obsolete: true

[Term]
id: CL:0000540
name: neuron
namespace: cell
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:A08.663, MESH:D009474]
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
synonym: "nerve cell" EXACT []
xref: BTO:0000938
xref: CALOHA:TS-0683
xref: FBbt:00005106
xref: FMA:54527
xref: VHOG:0001483
xref: WBbt:0003679
is_a: CL:0000000 ! cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: develops_from CL:0000031 ! neuroblast

[Term]
id: CL:0000541
name: melanoblast
namespace: cell
def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl]
comment: Derived from UBERON:0002342 neural crest.
xref: BTO:0003217
xref: FMA:83377
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000542
name: lymphocyte
namespace: cell
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149]
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
xref: BTO:0000775
xref: CALOHA:TS-0583
xref: FMA:62863
xref: VHOG:0001535
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm
intersection_of: has_part CP:0000037 ! increased nucleus size
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: lacks_part GO:0030141 ! secretory granule
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part CP:0000000 ! neutrophillic cytoplasm
relationship: has_part CP:0000037 ! increased nucleus size
relationship: has_part GO:0000792 ! heterochromatin
relationship: lacks_part GO:0030141 ! secretory granule

[Term]
id: CL:0000543
name: obsolete sieve tube member
namespace: cell
def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208]
comment: replaced_by: PO:0000289
synonym: "sieve tube element" EXACT []
is_obsolete: true

[Term]
id: CL:0000544
name: slowly adapting mechanoreceptor cell
namespace: cell
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000545
name: T-helper 1 cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells.
synonym: "helper T cell type 1" EXACT []
synonym: "T helper cells type 1" EXACT [PMID:9419219]
synonym: "T(H)-1 cell" EXACT []
synonym: "Th1 CD4+ T cell" EXACT [PMID:22343568]
synonym: "Th1 cell" EXACT []
synonym: "Th1 T cell" EXACT []
synonym: "Th1 T lymphocyte" EXACT []
synonym: "Th1 T-cell" EXACT []
synonym: "Th1 T-lymphocyte" EXACT []
xref: BTO:0001678
xref: FMA:84382
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21
intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001835 ! T-box transcription factor TBX21
relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6

[Term]
id: CL:0000546
name: T-helper 2 cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell.
synonym: "helper T cell type 2" EXACT []
synonym: "T helper cells type 2" EXACT [PMID:9419219]
synonym: "T(H)-2 cell" EXACT []
synonym: "Th2 cell" EXACT []
synonym: "Th2 T cell" EXACT []
synonym: "Th2 T lymphocyte" EXACT []
synonym: "Th2 T-cell" EXACT []
synonym: "Th2 T-lymphocyte" EXACT []
xref: BTO:0001679
xref: FMA:84385
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0000547
name: proerythroblast
namespace: cell
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021]
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: has_part CP:0000028 ! basophilic cytoplasm
intersection_of: has_part CP:0000037 ! increased nucleus size
intersection_of: has_part GO:0005634 ! nucleus
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: develops_from CL:0000038 ! erythroid progenitor cell
relationship: has_part CP:0000028 ! basophilic cytoplasm
relationship: has_part CP:0000037 ! increased nucleus size
relationship: has_part GO:0005634 ! nucleus
relationship: has_part GO:0005730 ! nucleolus
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G

[Term]
id: CL:0000548
name: animal cell
namespace: cell
subset: ubprop:upper_level
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000549
name: basophilic erythroblast
namespace: cell
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464]
synonym: "basophilic normoblast" EXACT [ISBN:0721601464]
synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CP:0000028 ! basophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: develops_from CL:0000547 ! proerythroblast
relationship: has_part CP:0000028 ! basophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000550
name: polychromatophilic erythroblast
namespace: cell
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464]
synonym: "intermediate erythroblast" EXACT [ISBN:0721601464]
synonym: "intermediate normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464]
synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CP:0000035 ! polychromatophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: develops_from CL:0000549 ! basophilic erythroblast
relationship: has_part CP:0000035 ! polychromatophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000551
name: unimodal nocireceptor
namespace: cell
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000552
name: orthochromatic erythroblast
namespace: cell
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464]
synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464]
synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464]
xref: FMA:84646
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CP:0000027 ! acidophilic cytoplasm
intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation
relationship: develops_from CL:0000550 ! polychromatophilic erythroblast
relationship: has_part CP:0000027 ! acidophilic cytoplasm
relationship: participates_in GO:0030263 ! apoptotic chromosome condensation

[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
namespace: cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT [PMCID:PMC1794060]
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498]
synonym: "MkP" EXACT [PMID:21116988]
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: BTO:0001164
xref: CALOHA:TS-0610
xref: FMA:84235
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0007113 ! endomitotic cell cycle
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: capable_of GO:0007113 ! endomitotic cell cycle
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000554
name: gastrin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [GOC:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000555
name: neuronal brush cell
namespace: cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000556
name: megakaryocyte
namespace: cell
def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533]
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000763 ! myeloid cell
intersection_of: bearer_of PATO:0001393 ! euploid
intersection_of: part_of UBERON:0002371 ! bone marrow
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: bearer_of PATO:0001393 ! euploid
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell
relationship: part_of UBERON:0002371 ! bone marrow

[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
namespace: cell
def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566]
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0011115 ! precursor cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030225 ! macrophage differentiation
intersection_of: capable_of GO:0030851 ! granulocyte differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: lacks_part PR:000007857 ! erythroid transcription factor
intersection_of: lacks_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: capable_of GO:0030225 ! macrophage differentiation
relationship: capable_of GO:0030851 ! granulocyte differentiation
relationship: develops_from CL:0000049 ! common myeloid progenitor
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: lacks_part PR:000007857 ! erythroid transcription factor
relationship: lacks_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: part_of UBERON:0002371 ! bone marrow

[Term]
id: CL:0000558
name: reticulocyte
namespace: cell
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622]
xref: BTO:0001173
xref: CALOHA:TS-0864
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0071971 ! extracellular exosome assembly
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: capable_of GO:0071971 ! extracellular exosome assembly
relationship: develops_from CL:0000552 ! orthochromatic erythroblast
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G

[Term]
id: CL:0000559
name: promonocyte
namespace: cell
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464]
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
xref: BTO:0004657
xref: FMA:83551
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: develops_from CL:0000040 ! monoblast
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0000560
name: band form neutrophil
namespace: cell
def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007]
comment: Found in the Band 1 fraction.
synonym: "band" BROAD []
synonym: "band cell" BROAD []
synonym: "band form" BROAD []
synonym: "rod neutrophil" EXACT []
synonym: "stab cell" BROAD []
is_a: CL:0000096 {is_inferred="true"} ! mature neutrophil
intersection_of: CL:0000096 ! mature neutrophil
intersection_of: has_part CP:0000039 ! banded nucleus
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001337 ! complement receptor type 1
intersection_of: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor
intersection_of: lacks_part PR:000009978 ! lactotransferrin
intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein
intersection_of: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4
intersection_of: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase
relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte
relationship: has_part CP:0000039 ! banded nucleus
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007597 ! proto-oncogene c-Fos
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001337 ! complement receptor type 1
relationship: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor
relationship: lacks_part PR:000009978 ! lactotransferrin
relationship: lacks_part PR:000010799 ! myb proto-oncogene protein
relationship: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4
relationship: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase

[Term]
id: CL:0000561
name: amacrine cell
namespace: cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A08.663.358.050]
comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748).
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FBbt:00005127
xref: FMA:67766
is_a: CL:0000099 ! interneuron
relationship: synapsed_to CL:0000740 ! retinal ganglion cell

[Term]
id: CL:0000562
name: nucleate erythrocyte
namespace: cell
def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: has_part GO:0005634 ! nucleus
relationship: develops_from CL:0002421 ! nucleated reticulocyte
relationship: has_part GO:0005634 ! nucleus

[Term]
id: CL:0000563
name: endospore
namespace: cell
def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256]
synonym: "bacterial spore" EXACT []
xref: BTO:0002779
is_a: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000564
name: neutrophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:12560239, PMID:15514007]
comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
synonym: "neutrophilic premyelocyte" EXACT []
synonym: "neutrophilic progranulocyte" EXACT []
xref: FMA:84196
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000836 {is_inferred="true"} ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: capable_of GO:0030223 ! neutrophil differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000010543 ! myeloperoxidase
intersection_of: has_part PR:000014362 ! runt-related transcription factor 1
intersection_of: lacks_part PR:000009978 ! lactotransferrin
relationship: capable_of GO:0030223 ! neutrophil differentiation
relationship: develops_from CL:0000042 ! neutrophilic myeloblast
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000010543 ! myeloperoxidase
relationship: has_part PR:000014362 ! runt-related transcription factor 1
relationship: lacks_part PR:000009978 ! lactotransferrin

[Term]
id: CL:0000565
name: fat body cell
namespace: cell
def: "A cell found in fat bodies whose primary function is intermediary metabolism." [FB:ma]
is_a: CL:0000181 ! metabolising cell

[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
namespace: cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5
intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2
intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5
relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2
relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1

[Term]
id: CL:0000567
name: polymodal nocireceptor
namespace: cell
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000568
name: amine precursor uptake and decarboxylation cell
namespace: cell
def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A11.070]
synonym: "APUD cell" EXACT []
xref: BTO:0003866
xref: FMA:83114
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000569
name: cardiac mesenchymal cell
namespace: cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864]
is_a: CL:0008019 ! mesenchymal cell
intersection_of: CL:0008019 ! mesenchymal cell
intersection_of: develops_into CL:0002494 ! cardiocyte
relationship: develops_into CL:0002494 ! cardiocyte

[Term]
id: CL:0000570
name: parafollicular cell
namespace: cell
def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [GOC:tfm, ISBN:0517223651]
synonym: "C cell" EXACT []
synonym: "C cell of thyroid gland" EXACT [FMA:68653]
synonym: "clear cell of thyroid gland" EXACT [FMA:68653]
synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653]
synonym: "thyroid parafollicular cell" EXACT [FMA:68653]
xref: FMA:68653
xref: SCTID:176770005
is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: capable_of GO:0001820 ! serotonin secretion
intersection_of: capable_of GO:0014046 ! dopamine secretion
intersection_of: capable_of GO:0036161 ! calcitonin secretion
intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: capable_of GO:0001820 ! serotonin secretion
relationship: capable_of GO:0014046 ! dopamine secretion
relationship: capable_of GO:0036161 ! calcitonin secretion
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland

[Term]
id: CL:0000571
name: leucophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005003 ! leucoblast

[Term]
id: CL:0000573
name: retinal cone cell
namespace: cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A08.663.650.650.670.100]
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell

[Term]
id: CL:0000574
name: erythrophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005004 ! pigment erythroblast

[Term]
id: CL:0000575
name: corneal epithelial cell
namespace: cell
alt_id: CL:1000431
def: "An epithelial cell of the cornea." [GOC:tfm]
synonym: "epithelial cell of cornea" EXACT [FMA:70551]
xref: BTO:0004298
xref: CALOHA:TS-0173
xref: FMA:70551
is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000964 ! cornea
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: CL:0000576
name: monocyte
namespace: cell
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:A11.118.637.555.652]
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
xref: BTO:0000876
xref: CALOHA:TS-0638
xref: FMA:62864
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0000842 ! mononuclear cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: bearer_of PATO:0001407 ! mononucleate
intersection_of: capable_of GO:0030225 ! macrophage differentiation
intersection_of: capable_of GO:0030316 ! osteoclast differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: lacks_part GO:0030141 ! secretory granule
relationship: bearer_of PATO:0001407 ! mononucleate
relationship: capable_of GO:0030225 ! macrophage differentiation
relationship: capable_of GO:0030316 ! osteoclast differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: develops_from CL:0000559 ! promonocyte
relationship: lacks_part GO:0030141 ! secretory granule

[Term]
id: CL:0000577
name: type EC enteroendocrine cell
namespace: cell
alt_id: CL:0002065
def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A03.492.766.440.250, PMID:9505449]
synonym: "argentaffin cell" EXACT []
synonym: "enterochromaffin cell" EXACT []
synonym: "Kulchitsky cell" EXACT []
xref: FMA:62934
xref: FMA:83132
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa

[Term]
id: CL:0000578
name: experimentally modified cell in vitro
namespace: cell
def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [FB:ma, ReO:mhb]
comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12
is_a: CL:0001034 ! cell in vitro

[Term]
id: CL:0000579
name: border follicle cell
namespace: cell
xref: FBbt:00004905
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000580
name: neutrophilic myelocyte
namespace: cell
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007]
comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
xref: BTO:0003455
xref: FMA:83540
is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002193 ! myelocyte
intersection_of: CL:0000776 ! immature neutrophil
intersection_of: has_part CP:0000027 ! acidophilic cytoplasm
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon
intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin
intersection_of: has_part PR:000009978 ! lactotransferrin
intersection_of: has_part PR:000010543 ! myeloperoxidase
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
intersection_of: lacks_part GO:0070820 ! tertiary granule
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: develops_from CL:0000564 ! neutrophilic promyelocyte
relationship: has_part CP:0000027 ! acidophilic cytoplasm
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon
relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin
relationship: has_part PR:000009978 ! lactotransferrin
relationship: has_part PR:000010543 ! myeloperoxidase
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: lacks_part GO:0070820 ! tertiary granule
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III

[Term]
id: CL:0000581
name: peritoneal macrophage
namespace: cell
def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:A11.329.372.630, PMID:15771589, PMID:19201820]
comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
xref: BTO:0001034
xref: FMA:83025
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0042742 ! defense response to bacterium
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: located_in UBERON:0001179 ! peritoneal cavity
relationship: capable_of GO:0042742 ! defense response to bacterium
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: located_in UBERON:0001179 ! peritoneal cavity

[Term]
id: CL:0000582
name: neutrophilic metamyelocyte
namespace: cell
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007]
comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
synonym: "juvenile neutrophil" EXACT []
xref: FMA:84197
is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil
is_a: CL:0002192 ! metamyelocyte
intersection_of: CL:0000776 ! immature neutrophil
intersection_of: has_part CP:0000027 ! acidophilic cytoplasm
intersection_of: has_part CP:0000040 ! reniform nucleus
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_part GO:0070820 ! tertiary granule
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon
intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin
intersection_of: has_part PR:000009978 ! lactotransferrin
intersection_of: has_part PR:000010543 ! myeloperoxidase
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
intersection_of: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor
relationship: develops_from CL:0000580 ! neutrophilic myelocyte
relationship: has_part CP:0000027 ! acidophilic cytoplasm
relationship: has_part CP:0000040 ! reniform nucleus
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_part GO:0070820 ! tertiary granule
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon
relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin
relationship: has_part PR:000009978 ! lactotransferrin
relationship: has_part PR:000010543 ! myeloperoxidase
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor

[Term]
id: CL:0000583
name: alveolar macrophage
namespace: cell
def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A11.329.372.600]
comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.
synonym: "dust cell" EXACT []
synonym: "MF.Lu" RELATED []
xref: BTO:0000802
xref: CALOHA:TS-0030
xref: FMA:83023
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
intersection_of: located_in UBERON:0002299 ! alveolus of lung
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1
relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
relationship: located_in UBERON:0002299 ! alveolus of lung

[Term]
id: CL:0000584
name: enterocyte
namespace: cell
def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl]
xref: BTO:0000398
xref: FMA:62122
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0000677 ! gut absorptive cell
is_a: CL:0002563 ! intestinal epithelial cell

[Term]
id: CL:0000585
name: obsolete null cell
namespace: cell
def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." []
comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context.
is_obsolete: true

[Term]
id: CL:0000586
name: germ cell
namespace: cell
def: "The reproductive cell in multicellular organisms." [MESH:A05.360.490]
xref: BTO:0000535
xref: VHOG:0001534
xref: WBbt:0006796
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
relationship: capable_of GO:0048609 ! multicellular organismal reproductive process

[Term]
id: CL:0000587
name: cold sensing thermoreceptor cell
namespace: cell
def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm]
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000588
name: odontoclast
namespace: cell
def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A11.329.679]
xref: BTO:0002516
xref: FMA:83027
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
intersection_of: CL:0000092 ! osteoclast
intersection_of: capable_of GO:0042483 ! negative regulation of odontogenesis
relationship: capable_of GO:0042483 ! negative regulation of odontogenesis

[Term]
id: CL:0000589
name: cochlear inner hair cell
namespace: cell
def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A08.663.650.250.250]
synonym: "inner hair cell" BROAD []
xref: BTO:0003667
xref: FMA:62365
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000590
name: small luteal cell
namespace: cell
def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400]
synonym: "small lutein cell" EXACT []
synonym: "theca lutein cell" EXACT []
xref: BTO:0002850
xref: FMA:18690
is_a: CL:0000175 ! luteal cell
relationship: develops_from CL:0000503 ! theca cell

[Term]
id: CL:0000591
name: warmth sensing thermoreceptor cell
namespace: cell
def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm]
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000592
name: large luteal cell
namespace: cell
def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400]
synonym: "granulosa lutein cell" EXACT []
synonym: "granulosoluteocytus" RELATED []
xref: FMA:18689
is_a: CL:0000175 ! luteal cell
is_a: CL:0000177 ! testosterone secreting cell
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000593
name: androgen secreting cell
namespace: cell
def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm]
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035935 ! androgen secretion
relationship: capable_of GO:0035935 ! androgen secretion

[Term]
id: CL:0000594
name: skeletal muscle satellite cell
namespace: cell
def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [GOC:tfm, MESH:A11.635.500.700, PMID:21849021, PMID:23303905]
comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts.  They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population.
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000680 ! muscle precursor cell
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000595
name: enucleate erythrocyte
namespace: cell
def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
intersection_of: CL:0000232 ! erythrocyte
intersection_of: bearer_of PATO:0001405 ! anucleate
relationship: bearer_of PATO:0001405 ! anucleate
relationship: develops_from CL:0002422 ! enucleated reticulocyte

[Term]
id: CL:0000596
name: sexual spore
namespace: cell
def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt]
synonym: "meiotically-derived spore" EXACT []
xref: FAO:0000017
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000597
name: microconidium
namespace: cell
def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt]
xref: FAO:0000028
is_a: CL:0002381 ! uninucleate conidium

[Term]
id: CL:0000598
name: pyramidal neuron
namespace: cell
def: "Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their  region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:A08.186.211.577.405.700]
synonym: "projection neuron" EXACT []
synonym: "pyramidal cell" EXACT []
synonym: "pyramidal neuron" EXACT []
xref: BTO:0003102
xref: FMA:67310
xref: FMA:86775
xref: NIFSTD:sao862606388
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000599
name: conidium
namespace: cell
def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt]
xref: BTO:0000283
xref: FAO:0000024
is_a: CL:0000605 ! fungal asexual spore

[Term]
id: CL:0000600
name: heterokaryon
namespace: cell
def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000601
name: outer hair cell
namespace: cell
def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A08.663.650.250.315]
synonym: "cochlear outer hair cell" EXACT []
xref: BTO:0003666
xref: FMA:62366
is_a: CL:0000202 ! auditory hair cell
relationship: part_of UBERON:0002227 ! spiral organ of cochlea

[Term]
id: CL:0000602
name: pressoreceptor cell
namespace: cell
def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A08.800.050.800.900.700]
is_a: CL:1000082 ! stretch receptor cell

[Term]
id: CL:0000603
name: dikaryon
namespace: cell
def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X]
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000600 ! heterokaryon

[Term]
id: CL:0000604
name: retinal rod cell
namespace: cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A08.663.650.650.670.650]
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell

[Term]
id: CL:0000605
name: fungal asexual spore
namespace: cell
def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt]
xref: FAO:0000023
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000606
name: macroconidium
namespace: cell
def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt]
xref: FAO:0000038
is_a: CL:0000599 ! conidium

[Term]
id: CL:0000607
name: ascospore
namespace: cell
def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt]
xref: BTO:0000097
xref: FAO:0000020
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000608
name: zygospore
namespace: cell
def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt]
xref: FAO:0000040
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000609
name: vestibular hair cell
namespace: cell
def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A08.663.650.250.380]
synonym: "vestibular receptor cell" EXACT []
xref: FMA:62351
is_a: CL:0002374 ! ear hair cell

[Term]
id: CL:0000610
name: obsolete plant cell
namespace: cell
comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO)
is_obsolete: true
consider: PO:0009002

[Term]
id: CL:0000611
name: eosinophil progenitor cell
namespace: cell
comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76).
synonym: "CFU-Eo" RELATED []
synonym: "colony forming unit eosinophil" RELATED []
synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675]
synonym: "eosinophil stem cell" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: capable_of GO:0030222 ! eosinophil differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: capable_of GO:0030222 ! eosinophil differentiation
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000612
name: eosinophilic myelocyte
namespace: cell
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087]
xref: BTO:0003454
xref: FMA:83542
is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil
is_a: CL:0002087 ! nongranular leukocyte
is_a: CL:0002193 ! myelocyte
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
intersection_of: lacks_part GO:0070820 ! tertiary granule
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: lacks_part GO:0070820 ! tertiary granule
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III

[Term]
id: CL:0000613
name: basophil progenitor cell
namespace: cell
def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421]
comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf).
synonym: "BaP" EXACT []
synonym: "basophilic stem cell" RELATED []
synonym: "CFU-Bas" RELATED []
synonym: "colony forming unit basophil" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: capable_of GO:0030221 ! basophil differentiation
intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: capable_of GO:0030221 ! basophil differentiation
relationship: develops_from CL:0002028 ! basophil mast progenitor cell
relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000614
name: basophilic myelocyte
namespace: cell
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030]
xref: BTO:0003456
xref: FMA:83543
is_a: CL:0000768 {is_inferred="true"} ! immature basophil
is_a: CL:0002087 ! nongranular leukocyte
intersection_of: CL:0000768 ! immature basophil
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
intersection_of: lacks_part GO:0005730 ! nucleolus
intersection_of: lacks_part GO:0070820 ! tertiary granule
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: develops_from CL:0000830 ! basophilic promyelocyte
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: lacks_part GO:0005730 ! nucleolus
relationship: lacks_part GO:0070820 ! tertiary granule
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III

[Term]
id: CL:0000615
name: basidiospore
namespace: cell
def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X]
xref: BTO:0002166
xref: FAO:0000021
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000616
name: obsolete sporangiospore
namespace: cell
def: "OBSOLETE: A walled spore produced in a sporangium." [ISBN:08199377X]
is_obsolete: true

[Term]
id: CL:0000617
name: GABAergic neuron
namespace: cell
def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm]
synonym: "GABA-ergic neuron" EXACT []
xref: FMA:84788
xref: WBbt:0005190
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:0000618
name: sheath cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000619
name: support cell (sensu Nematoda)
namespace: cell
is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia)
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000620
name: obsolete zoospore
namespace: cell
def: "OBSOLETE: A sporangiospore that is motile, having flagella." [ISBN:08199377X]
xref: FAO:0000039
is_obsolete: true

[Term]
id: CL:0000621
name: fusion competent myoblast
namespace: cell
def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." [PMID:22274696]
is_a: CL:0008018 ! somatic muscle myoblast
relationship: develops_into CL:0008003 ! somatic muscle myotube

[Term]
id: CL:0000622
name: acinar cell
namespace: cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de]
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
xref: FMA:83625
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000154 ! protein secreting cell
relationship: part_of UBERON:0009842 ! glandular acinus

[Term]
id: CL:0000623
name: natural killer cell
namespace: cell
def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
xref: BTO:0000914
xref: BTO:0004716
xref: CALOHA:TS-0664
xref: FMA:63147
xref: FMA:83601
xref: VHOG:0001697
is_a: CL:0001067 {is_inferred="true"} ! group 1 innate lymphoid cell
intersection_of: CL:0001067 ! group 1 innate lymphoid cell
intersection_of: capable_of GO:0002228 ! natural killer cell mediated immunity
intersection_of: capable_of GO:0050776 ! regulation of immune response
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: capable_of GO:0002228 ! natural killer cell mediated immunity
relationship: capable_of GO:0050776 ! regulation of immune response
relationship: develops_from CL:0000825 ! pro-NK cell
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule

[Term]
id: CL:0000624
name: CD4-positive, alpha-beta T cell
namespace: cell
def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0000625
name: CD8-positive, alpha-beta T cell
namespace: cell
def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule

[Term]
id: CL:0000626
name: olfactory granule cell
namespace: cell
def: "Granule cell that is part of the olfactory bulb." [GOC:mah]
is_a: CL:0000120 ! granule cell
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0002264 ! olfactory bulb
relationship: part_of UBERON:0002264 ! olfactory bulb

[Term]
id: CL:0000627
name: transporting cell
namespace: cell
def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr]
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000628
name: photosynthetic cell
namespace: cell
def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr]
comment: see PMID:21177950, The making of a photosynthetic animal.
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000629
name: storage cell
namespace: cell
def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma]
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000630
name: supportive cell
namespace: cell
def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm]
xref: BTO:0002315
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000631
name: labyrinth supporting cell
namespace: cell
def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A09.246.631.246.577.543]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000632
name: hepatic stellate cell
namespace: cell
def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
synonym: "fat-storing cell" RELATED []
synonym: "hepatic perisinusoidal cell" EXACT []
synonym: "Ito cell" EXACT []
synonym: "lipocyte" RELATED []
synonym: "perisinusoidal cell" EXACT []
synonym: "vitamin A-storing cells" RELATED [PMID:12808230]
xref: BTO:0002741
xref: CALOHA:TS-0452
xref: FMA:67763
is_a: CL:0000057 ! fibroblast
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000327 ! extracellular matrix secreting cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein
intersection_of: part_of UBERON:0002107 ! liver
relationship: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000633
name: Hensen cell
namespace: cell
def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544]
synonym: "cell of Hensen" EXACT []
synonym: "external limiting cell of organ of Corti" EXACT []
synonym: "Hensen's cell" EXACT []
xref: FMA:79799
is_a: CL:0002490 ! organ of Corti supporting cell

[Term]
id: CL:0000634
name: Claudius cell
namespace: cell
def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544]
synonym: "cell of Claudius" EXACT []
synonym: "external supporting cell of Claudius" RELATED []
synonym: "external supporting cell of vestibular epithelium" EXACT []
xref: FMA:79802
is_a: CL:0002315 ! supporting cell of cochlea

[Term]
id: CL:0000635
name: Deiter's cell
namespace: cell
def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544]
synonym: "Deiters cell" EXACT []
synonym: "outer phalangeal cell" EXACT []
xref: FMA:75725
is_a: CL:0002165 ! phalangeal cell

[Term]
id: CL:0000636
name: Mueller cell
namespace: cell
xref: BTO:0003064
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000637
name: chromophil cell of anterior pituitary gland
namespace: cell
def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256]
xref: FMA:83089
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002196 ! adenohypophysis
relationship: capable_of GO:0030072 ! peptide hormone secretion
relationship: part_of UBERON:0002196 ! adenohypophysis

[Term]
id: CL:0000638
name: acidophil cell of pars distalis of adenohypophysis
namespace: cell
def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm]
synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars distalis of adenohypophysis" EXACT []
synonym: "pituitary alpha cell" EXACT []
xref: FMA:83093
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland
relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis

[Term]
id: CL:0000639
name: basophil cell of pars distalis of adenohypophysis
namespace: cell
def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm]
synonym: "basophil cell of anterior lobe of hypophysis" EXACT []
synonym: "beta cell" RELATED []
synonym: "pituitary beta cell" RELATED []
xref: FMA:83094
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland

[Term]
id: CL:0000641
name: chromophobe cell
namespace: cell
def: "A cell that is resistant to stains." [GOC:tfm]
synonym: "chromophobic cell" EXACT []
xref: FMA:83626
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000642
name: folliculostellate cell
namespace: cell
def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb]
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000644
name: Bergmann glial cell
namespace: cell
def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell]
synonym: "Bergmann astrocyte" EXACT []
synonym: "Bergmann glial cell of cerebellum" EXACT []
xref: FMA:54559
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000645
name: pituicyte
namespace: cell
def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651]
xref: BTO:0003793
xref: FMA:83503
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000646
name: basal cell
namespace: cell
def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651]
xref: BTO:0000939
xref: FMA:62516
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000647
name: multinucleated giant cell
namespace: cell
def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783]
comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this.
synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
xref: BTO:0003107
xref: FMA:83035
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: bearer_of PATO:0001908 ! multinucleate
intersection_of: participates_in GO:0002432 ! granuloma formation
intersection_of: participates_in GO:0002544 ! chronic inflammatory response
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: develops_from CL:0000235 ! macrophage
relationship: participates_in GO:0002432 ! granuloma formation
relationship: participates_in GO:0002544 ! chronic inflammatory response

[Term]
id: CL:0000648
name: kidney granular cell
namespace: cell
alt_id: CL:0000461
def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727]
synonym: "JG cell" EXACT []
synonym: "juxtaglomerular cell" BROAD []
synonym: "renin secreting cell" EXACT []
xref: FMA:84138
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1000618 ! juxtaglomerular complex cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0002001 ! renin secretion into blood stream
intersection_of: part_of UBERON:0002113 ! kidney
relationship: capable_of GO:0002001 ! renin secretion into blood stream
relationship: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus

[Term]
id: CL:0000649
name: prickle cell
namespace: cell
alt_id: CL:0002186
def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181]
synonym: "prickle cell of epidermis" EXACT []
xref: FMA:69059
is_a: CL:0000312 ! keratinocyte
relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis

[Term]
id: CL:0000650
name: mesangial cell
namespace: cell
def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells]
comment: Do all of these cells really develop from some mesenchymal stem cell?
synonym: "kidney mesangial cell" EXACT []
xref: BTO:0000853
xref: CALOHA:TS-0617
xref: FMA:70972
is_a: CL:0000669 ! pericyte cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell

[Term]
id: CL:0000651
name: mucous neck cell
namespace: cell
def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm]
synonym: "neck cell" BROAD []
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell
relationship: capable_of GO:0070254 ! mucus secretion

[Term]
id: CL:0000652
name: pinealocyte
namespace: cell
def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276]
xref: BTO:0001068
xref: FMA:83417
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0030187 ! melatonin biosynthetic process
relationship: part_of UBERON:0001905 ! pineal body

[Term]
id: CL:0000653
name: glomerular visceral epithelial cell
namespace: cell
def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:tfm]
comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm].
synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967]
synonym: "glomerular podocyte" EXACT [FMA:70967]
synonym: "podocyte" EXACT []
xref: BTO:0002295
is_a: CL:0002522 ! renal filtration cell
is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule
relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule

[Term]
id: CL:0000654
name: primary oocyte
namespace: cell
def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544]
synonym: "primary oogonium" RELATED []
xref: BTO:0000512
xref: FMA:18645
is_a: CL:0000023 {is_inferred="true"} ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: has_not_completed GO:0007126 ! meiotic nuclear division
relationship: develops_from CL:0000024 ! oogonial cell
relationship: has_not_completed GO:0007126 ! meiotic nuclear division

[Term]
id: CL:0000655
name: secondary oocyte
namespace: cell
def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544]
synonym: "primary oogonium" RELATED []
xref: BTO:0003094
xref: FMA:18646
is_a: CL:0000654 ! primary oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: has_not_completed GO:0007147 ! female meiosis II
relationship: develops_from CL:0000654 ! primary oocyte
relationship: has_not_completed GO:0007147 ! female meiosis II

[Term]
id: CL:0000656
name: primary spermatocyte
namespace: cell
def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544]
xref: BTO:0001115
xref: CALOHA:TS-2194
xref: FMA:72292
is_a: CL:0000017 {is_inferred="true"} ! spermatocyte
intersection_of: CL:0000017 ! spermatocyte
intersection_of: bearer_of PATO:0001394 ! diploid
intersection_of: capable_of GO:0007140 ! male meiosis
relationship: bearer_of PATO:0001394 ! diploid
relationship: capable_of GO:0007140 ! male meiosis

[Term]
id: CL:0000657
name: secondary spermatocyte
namespace: cell
def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544]
xref: BTO:0000709
xref: CALOHA:TS-2195
xref: FBbt:00004941
xref: FMA:72293
is_a: CL:0000017 {is_inferred="true"} ! spermatocyte
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: bearer_of PATO:0001375 ! haploid
intersection_of: capable_of GO:0007142 ! male meiosis II
relationship: bearer_of PATO:0001375 ! haploid
relationship: capable_of GO:0007142 ! male meiosis II
relationship: develops_from CL:0000656 ! primary spermatocyte

[Term]
id: CL:0000658
name: cuticle secreting cell
namespace: cell
def: "An epithelial cell that secretes cuticle." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000659
name: eggshell secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes eggshell." [GOC:tfm]
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000500 ! follicular epithelial cell

[Term]
id: CL:0000660
name: glycocalyx secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes glycocalyx." [GOC:tfm]
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000661
name: distal tip cell (sensu Nematoda)
namespace: cell
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000662
name: neuroglioblast (sensu Nematoda)
namespace: cell
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000663
name: valve cell
namespace: cell
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000664
name: closable valve cell
namespace: cell
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000665
name: permanently open valve cell
namespace: cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000666
name: fenestrated cell
namespace: cell
synonym: "window cell" EXACT []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000667
name: collagen secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000668
name: obsolete parenchymal cell
namespace: cell
def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208]
comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074.
xref: BTO:0002174
xref: FMA:84638
is_obsolete: true

[Term]
id: CL:0000669
name: pericyte cell
namespace: cell
alt_id: CL:0000184
def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907]
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.
synonym: "adventitial cell" RELATED []
synonym: "adventitial reticular cell" EXACT []
synonym: "ARC" EXACT [PMID:17986482]
synonym: "cell of Rouget" EXACT []
synonym: "pericyte" EXACT []
synonym: "pericyte of Rouget" EXACT []
xref: BTO:0002441
xref: FMA:63174
is_a: CL:0000183 ! contractile cell
is_a: CL:0000630 ! supportive cell
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000670
name: primordial germ cell
namespace: cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
xref: FMA:70567
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
is_a: CL:0000219 {is_inferred="true"} ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0048870 ! cell motility
intersection_of: part_of UBERON:0000922 ! embryo
relationship: capable_of GO:0048870 ! cell motility
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: CL:0000671
name: centripetally migrating follicle cell
namespace: cell
xref: FBbt:00004906
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000672
name: obsolete tracheary element
namespace: cell
def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [ISBN:0471245208]
comment: replaced_by: PO:0000290
is_obsolete: true

[Term]
id: CL:0000673
name: Kenyon cell
namespace: cell
is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia)

[Term]
id: CL:0000674
name: interfollicle cell
namespace: cell
synonym: "fly stalk cell" EXACT []
xref: FBbt:00004910
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000675
name: female gamete
namespace: cell
def: "A mature sexual reproductive cell of the female germline." [GOC:tfm]
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000676
name: cap cell
namespace: cell
xref: BTO:0001033
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000677
name: gut absorptive cell
namespace: cell
def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb]
is_a: CL:0000212 ! absorptive cell

[Term]
id: CL:0000678
name: commissural neuron
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000679
name: glutamatergic neuron
namespace: cell
xref: WBbt:0006829
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission

[Term]
id: CL:0000680
name: muscle precursor cell
namespace: cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_into CL:0000187 ! muscle cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_into CL:0000187 ! muscle cell

[Term]
id: CL:0000681
name: radial glial cell
namespace: cell
def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph]
comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life.
synonym: "forebrain radial glial cell" NARROW []
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000710 ! neurecto-epithelial cell

[Term]
id: CL:0000682
name: M cell of gut
namespace: cell
def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm]
comment: Should double check and see if M cells are particular to a specific region.
synonym: "M cell" BROAD []
synonym: "M-cell" EXACT []
synonym: "microfold cell" EXACT []
xref: BTO:0003600
xref: FMA:62929
is_a: CL:0000473 ! defensive cell
is_a: CL:0000627 ! transporting cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
relationship: part_of UBERON:0003929 ! digestive tract epithelium

[Term]
id: CL:0000683
name: ependymoglial cell
namespace: cell
def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb]
synonym: "ependymal astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000684
name: littoral cell of liver
namespace: cell
is_a: CL:0000077 ! mesothelial cell
relationship: part_of UBERON:0002107 ! liver

[Term]
id: CL:0000685
name: obsolete meristematic cell
namespace: cell
def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010]
comment: replaced_by: PO:0004010
is_obsolete: true

[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
namespace: cell
def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm]
is_a: CL:0000151 {is_inferred="true"} ! secretory cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0033326 ! cerebrospinal fluid secretion
relationship: capable_of GO:0033326 ! cerebrospinal fluid secretion
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000687
name: R1 photoreceptor cell
namespace: cell
synonym: "R1 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000688
name: perijunctional fibroblast
namespace: cell
def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb]
is_a: CL:0000057 ! fibroblast
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000689
name: myoendocrine cell
namespace: cell
def: "A cell with both myofibrils and secretory granules." [JB:jb]
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000690
name: R2 photoreceptor cell
namespace: cell
synonym: "R2 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000691
name: stellate interneuron
namespace: cell
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000692
name: terminal Schwann cell
namespace: cell
def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171]
synonym: "Schwann cell" BROAD []
is_a: CL:0000630 ! supportive cell
is_a: CL:0002376 ! non-myelinating Schwann cell

[Term]
id: CL:0000693
name: neuroglioform cell
namespace: cell
def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb]
synonym: "spiderweb cell" EXACT []
is_a: CL:0000691 ! stellate interneuron

[Term]
id: CL:0000694
name: R3 photoreceptor cell
namespace: cell
synonym: "R3 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000695
name: Cajal-Retzius cell
namespace: cell
def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912]
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000696
name: PP cell
namespace: cell
def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415]
synonym: "type F enteroendocrine cell" EXACT []
xref: FMA:62938
xref: FMA:83409
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000697
name: R4 photoreceptor cell
namespace: cell
synonym: "R4 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000698
name: obsolete paraganglial cell
namespace: cell
is_obsolete: true

[Term]
id: CL:0000699
name: paraganglial type 1 cell
namespace: cell
def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [GOC:tfm]
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000700
name: dopaminergic neuron
namespace: cell
def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill]
synonym: "dopaminergic cell" EXACT []
xref: BTO:0004032
xref: FMA:84787
xref: WBbt:0006746
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission
relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission

[Term]
id: CL:0000701
name: paraganglia type 2 cell
namespace: cell
def: "Supports paraganglial type 1 cell." [JB:jb]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000702
name: R5 photoreceptor cell
namespace: cell
synonym: "R5 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000703
name: sustentacular cell
namespace: cell
def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb]
xref: BTO:0002315
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000704
name: endothelial tip cell
namespace: cell
def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331]
is_a: CL:0000071 ! blood vessel endothelial cell

[Term]
id: CL:0000705
name: R6 photoreceptor cell
namespace: cell
synonym: "R6 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000706
name: choroid plexus epithelial cell
namespace: cell
alt_id: CL:1000430
def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134]
synonym: "epithelial cell of choroid plexus" EXACT []
xref: FMA:70549
is_a: CL:0000065 ! ependymal cell
is_a: CL:0000627 ! transporting cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000065 ! ependymal cell
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus

[Term]
id: CL:0000707
name: R7 photoreceptor cell
namespace: cell
synonym: "R7 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000494 ! UV sensitive photoreceptor cell

[Term]
id: CL:0000708
name: leptomeningeal cell
namespace: cell
def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb]
synonym: "leptomemingeal cell" RELATED []
is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000327 ! extracellular matrix secreting cell
intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier
relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier

[Term]
id: CL:0000709
name: R8 photoreceptor cell
namespace: cell
synonym: "R8 cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000710
name: neurecto-epithelial cell
namespace: cell
def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm]
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: FMA:70557
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: develops_from CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000711
name: cumulus cell
namespace: cell
def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [GOC:tfm, http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells]
xref: BTO:0002236
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002174 ! follicular cell of ovary
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000712
name: stratum granulosum cell
namespace: cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000362 ! epidermal cell
intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis
relationship: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis

[Term]
id: CL:0000713
name: corona radiata cell
namespace: cell
is_a: CL:0000711 ! cumulus cell

[Term]
id: CL:0000715
name: embryonic crystal cell
namespace: cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000716
name: lymph gland crystal cell
namespace: cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000717
name: fusimotor neuron
namespace: cell
def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775]
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000718
name: compound eye cone cell
namespace: cell
synonym: "cone cell (sensu Endopterygota)" RELATED []
is_a: CL:0000306 ! crystallin accumulating cell
relationship: part_of UBERON:0000018 ! compound eye

[Term]
id: CL:0000719
name: posterior cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000720
name: anterior cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000721
name: equatorial cone cell (sensu Endopterygota)
namespace: cell
is_a: CL:0000718 ! compound eye cone cell

[Term]
id: CL:0000722
name: cystoblast
namespace: cell
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000723
name: somatic stem cell
namespace: cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103]
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0000034 {is_inferred="true"} ! stem cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000034 ! stem cell
intersection_of: capable_of GO:0048103 ! somatic stem cell division
relationship: capable_of GO:0048103 ! somatic stem cell division

[Term]
id: CL:0000724
name: heterocyst
namespace: cell
def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma]
xref: BTO:0000600
is_a: CL:0000520 ! prokaryotic cell
is_a: CL:0000725 ! nitrogen fixing cell

[Term]
id: CL:0000725
name: nitrogen fixing cell
namespace: cell
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0009399 ! nitrogen fixation
relationship: capable_of GO:0009399 ! nitrogen fixation

[Term]
id: CL:0000726
name: chlamydospore
namespace: cell
def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X]
comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus.
is_a: CL:0000605 ! fungal asexual spore

[Term]
id: CL:0000727
name: primary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000728
name: secondary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000729
name: tertiary pigment cell
namespace: cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000730
name: leading edge cell
namespace: cell
def: "A cell at the front of a migrating epithelial sheet." [MA:ma]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000731
name: urothelial cell
namespace: cell
def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma]
synonym: "bladder transitional cell" NARROW []
synonym: "transitional epithelial cell of urinary bladder" NARROW []
synonym: "urinary tract transitional epithelial cell" NARROW []
xref: FMA:84127
is_a: CL:0000244 {is_inferred="true"} ! transitional epithelial cell
intersection_of: CL:0000244 ! transitional epithelial cell
intersection_of: part_of UBERON:0000365 ! urothelium
relationship: part_of UBERON:0000365 ! urothelium

[Term]
id: CL:0000732
name: amoeboid cell
namespace: cell
is_a: CL:0000219 ! motile cell

[Term]
id: CL:0000733
name: lymph gland plasmatocyte
namespace: cell
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000734
name: embryonic gland plasmatocyte
namespace: cell
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000735
name: lymph gland hemocyte
namespace: cell
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000736
name: embryonic gland hemocyte
namespace: cell
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000737
name: striated muscle cell
namespace: cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
xref: BTO:0002916
xref: CALOHA:TS-2157
xref: FMA:86936
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: bearer_of PATO:0001410 ! striated
intersection_of: has_part GO:0030017 ! sarcomere
disjoint_from: CL:0008000 ! non-striated muscle cell
relationship: bearer_of PATO:0001410 ! striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0000738
name: leukocyte
namespace: cell
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0]
synonym: "immune cell" EXACT []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
xref: BTO:0000751
xref: CALOHA:TS-0549
xref: FMA:62852
is_a: CL:0000219 ! motile cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: CL:0000740
name: retinal ganglion cell
namespace: cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph]
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" EXACT []
xref: BTO:0001800
xref: FMA:67765
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0000966 ! retina

[Term]
id: CL:0000741
name: spinal accessory motor neuron
namespace: cell
def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219]
synonym: "SACMN" EXACT []
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000742
name: periarticular chondrocyte
namespace: cell
def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842]
is_a: CL:1001607 ! articular chondrocyte
relationship: part_of UBERON:0010996 ! articular cartilage of joint

[Term]
id: CL:0000743
name: hypertrophic chondrocyte
namespace: cell
def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [GO_REF:0000034, PMID:15951842]
comment: is hypertrophic pathological or normal? and can it be described using a pato term?
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000744
name: columnar chondrocyte
namespace: cell
def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842]
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000745
name: retina horizontal cell
namespace: cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0003902 ! retinal neural layer

[Term]
id: CL:0000746
name: cardiac muscle cell
namespace: cell
alt_id: FMA:83808
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263]
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods.  The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein).  According to these refs, the cells participating in heart contraction in all cases are transversely striated.  Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
synonym: "cardiac muscle fiber" EXACT [GO:0048739]
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:14067
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: bearer_of PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
intersection_of: participates_in GO:0060047 ! heart contraction
relationship: bearer_of PATO:0002478 ! transversely striated
relationship: develops_from CL:0000513 ! cardiac muscle myoblast
relationship: has_part GO:0030017 ! sarcomere
relationship: part_of UBERON:0007100 ! primary circulatory organ
relationship: participates_in GO:0060047 ! heart contraction

[Term]
id: CL:0000747
name: cyanophore
namespace: cell
def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl]
synonym: "blue chromatophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005005 ! cyanoblast

[Term]
id: CL:0000748
name: retinal bipolar neuron
namespace: cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000103 ! bipolar neuron
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina

[Term]
id: CL:0000749
name: ON-bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000750
name: OFF-bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000751
name: rod bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [GOC:tfm, PMID:14689473]
xref: FMA:67750
is_a: CL:0000749 ! ON-bipolar cell

[Term]
id: CL:0000752
name: cone retinal bipolar cell
namespace: cell
def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000753
name: type 1 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473]
synonym: "DB1 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000754
name: type 2 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473]
synonym: "FMB cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000755
name: type 3 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473]
synonym: "DB2 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000756
name: type 4 cone bipolar cell (sensu Mus)
namespace: cell
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473]
synonym: "DB3 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000757
name: type 5 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473]
synonym: "DB4 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000758
name: type 6 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473]
synonym: "DB5 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000759
name: type 7 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473]
synonym: "IMB cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000760
name: type 8 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473]
synonym: "DB6 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000761
name: type 9 cone bipolar cell (sensu Mus)
namespace: cell
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473]
synonym: "BB cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000762
name: nucleated thrombocyte
namespace: cell
def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205]
comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals.
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
intersection_of: CL:0000763 ! myeloid cell
intersection_of: bearer_of PATO:0001407 ! mononucleate
intersection_of: capable_of GO:0007596 ! blood coagulation
relationship: bearer_of PATO:0001407 ! mononucleate
relationship: capable_of GO:0007596 ! blood coagulation
relationship: develops_from CL:0000828 ! thromboblast

[Term]
id: CL:0000763
name: myeloid cell
namespace: cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add]
xref: BTO:0001441
xref: CALOHA:TS-0647
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000764
name: erythroid lineage cell
namespace: cell
alt_id: CL:0002156
def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm]
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
synonym: "erythropoietic cell" EXACT []
xref: CALOHA:TS-0290
xref: FMA:62845
xref: FMA:83516
is_a: CL:0000763 ! myeloid cell

[Term]
id: CL:0000765
name: erythroblast
namespace: cell
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176]
synonym: "normoblast" EXACT []
xref: BTO:0001571
xref: CALOHA:TS-0289
xref: FMA:83504
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: has_part GO:0005634 ! nucleus
intersection_of: lacks_part GO:0005730 ! nucleolus
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: develops_from CL:0000547 ! proerythroblast
relationship: has_part GO:0005634 ! nucleus
relationship: lacks_part GO:0005730 ! nucleolus
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G

[Term]
id: CL:0000766
name: myeloid leukocyte
namespace: cell
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000767
name: basophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081]
comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.
synonym: "basophilic leucocyte" EXACT []
synonym: "basophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0000129
xref: CALOHA:TS-0073
xref: FMA:62862
is_a: CL:0000094 {is_inferred="true"} ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: has_high_plasma_membrane_amount PR:000001255 ! C-C chemokine receptor type 3
intersection_of: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3
intersection_of: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5
relationship: has_high_plasma_membrane_amount PR:000001255 ! C-C chemokine receptor type 3
relationship: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3
relationship: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5

[Term]
id: CL:0000768
name: immature basophil
namespace: cell
def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464]
synonym: "immature basophilic leucocyte" EXACT []
synonym: "immature basophilic leukocyte" EXACT []
is_a: CL:0000767 {is_inferred="true"} ! basophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000767 ! basophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus
relationship: develops_from CL:0000830 ! basophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus

[Term]
id: CL:0000769
name: basophilic metamyelocyte
namespace: cell
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030]
xref: FMA:84198
is_a: CL:0000768 {is_inferred="true"} ! immature basophil
is_a: CL:0002192 ! metamyelocyte
intersection_of: CL:0000768 ! immature basophil
intersection_of: has_part CP:0000040 ! reniform nucleus
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_part GO:0070820 ! tertiary granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: develops_from CL:0000614 ! basophilic myelocyte
relationship: has_part CP:0000040 ! reniform nucleus
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_part GO:0070820 ! tertiary granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N

[Term]
id: CL:0000770
name: band form basophil
namespace: cell
def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030]
is_a: CL:0000768 {is_inferred="true"} ! immature basophil
intersection_of: CL:0000768 ! immature basophil
intersection_of: has_part CP:0000039 ! banded nucleus
relationship: develops_from CL:0000769 ! basophilic metamyelocyte
relationship: has_part CP:0000039 ! banded nucleus

[Term]
id: CL:0000771
name: eosinophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676]
comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
synonym: "eosinocyte" EXACT []
synonym: "eosinophilic granulocyte" EXACT []
synonym: "eosinophilic leucocyte" EXACT []
synonym: "eosinophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0000399
xref: CALOHA:TS-0279
xref: FMA:62861
is_a: CL:0000094 {is_inferred="true"} ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: has_plasma_membrane_part PR:000001254 ! C-C chemokine receptor type 1
intersection_of: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule
relationship: has_plasma_membrane_part PR:000001254 ! C-C chemokine receptor type 1
relationship: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule

[Term]
id: CL:0000772
name: immature eosinophil
namespace: cell
def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464]
synonym: "immature eosinocyte" EXACT []
synonym: "immature eosinophilic leucocyte" EXACT []
synonym: "immature eosinophilic leukocyte" EXACT []
is_a: CL:0000771 {is_inferred="true"} ! eosinophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000771 ! eosinophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus
relationship: develops_from CL:0000833 ! eosinophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus

[Term]
id: CL:0000773
name: eosinophilic metamyelocyte
namespace: cell
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087]
is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil
is_a: CL:0002192 ! metamyelocyte
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: has_part CP:0000027 ! acidophilic cytoplasm
intersection_of: has_part CP:0000040 ! reniform nucleus
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_part GO:0070820 ! tertiary granule
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N
relationship: develops_from CL:0000612 ! eosinophilic myelocyte
relationship: has_part CP:0000027 ! acidophilic cytoplasm
relationship: has_part CP:0000040 ! reniform nucleus
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_part GO:0070820 ! tertiary granule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N

[Term]
id: CL:0000774
name: band form eosinophil
namespace: cell
def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087]
is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil
intersection_of: CL:0000772 ! immature eosinophil
intersection_of: has_part CP:0000039 ! banded nucleus
relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte
relationship: has_part CP:0000039 ! banded nucleus

[Term]
id: CL:0000775
name: neutrophil
namespace: cell
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464]
synonym: "neutrocyte" EXACT []
synonym: "neutrophil leucocyte" EXACT []
synonym: "neutrophil leukocyte" EXACT []
synonym: "neutrophilic leucocyte" EXACT []
synonym: "neutrophilic leukocyte" EXACT []
synonym: "PMN" BROAD []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" BROAD []
synonym: "polynuclear neutrophilic leucocyte" BROAD []
synonym: "polynuclear neutrophilic leukocyte" BROAD []
xref: BTO:0000130
xref: CALOHA:TS-0688
xref: FMA:62860
is_a: CL:0000094 {is_inferred="true"} ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin

[Term]
id: CL:0000776
name: immature neutrophil
namespace: cell
def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464]
synonym: "immatuer neutrophilic leukocyte" EXACT []
synonym: "immature neutrocyte" EXACT []
synonym: "immature neutrophil leucocyte" EXACT []
synonym: "immature neutrophil leukocyte" EXACT []
synonym: "immature neutrophilic leucocyte" EXACT []
is_a: CL:0000775 {is_inferred="true"} ! neutrophil
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000775 ! neutrophil
intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus
relationship: develops_from CL:0000564 ! neutrophilic promyelocyte
relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus

[Term]
id: CL:0000777
name: mesangial phagocyte
namespace: cell
def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841]
synonym: "mesangial cell" BROAD []
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: capable_of GO:0048771 ! tissue remodeling
intersection_of: located_in UBERON:0002320 ! glomerular mesangium
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: capable_of GO:0048771 ! tissue remodeling
relationship: located_in UBERON:0002320 ! glomerular mesangium

[Term]
id: CL:0000778
name: mononuclear osteoclast
namespace: cell
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452]
comment: Morphology: mononuclear, highly vesicular.
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
is_a: CL:0000226 ! single nucleate cell
intersection_of: CL:0000092 ! osteoclast
intersection_of: bearer_of PATO:0001407 ! mononucleate
relationship: bearer_of PATO:0001407 ! mononucleate

[Term]
id: CL:0000779
name: multinuclear osteoclast
namespace: cell
def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular.
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000092 ! osteoclast
intersection_of: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: develops_from CL:0000778 ! mononuclear osteoclast

[Term]
id: CL:0000780
name: multinuclear odontoclast
namespace: cell
def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth.
synonym: "multinucleated odontoclast" EXACT []
is_a: CL:0000588 {is_inferred="true"} ! odontoclast
is_a: CL:0000779 ! multinuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: develops_from CL:0000781 ! mononuclear odontoclast

[Term]
id: CL:0000781
name: mononuclear odontoclast
namespace: cell
def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth.
is_a: CL:0000588 {is_inferred="true"} ! odontoclast
is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: bearer_of PATO:0001407 ! mononucleate
relationship: bearer_of PATO:0001407 ! mononucleate

[Term]
id: CL:0000782
name: myeloid dendritic cell
namespace: cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
synonym: "veiled cell" BROAD []
xref: BTO:0004721
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: develops_from CL:0000763 ! myeloid cell
intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000576 ! monocyte
relationship: develops_from CL:0000763 ! myeloid cell
relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain

[Term]
id: CL:0000783
name: multinucleated phagocyte
namespace: cell
def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0001908 ! multinucleate

[Term]
id: CL:0000784
name: plasmacytoid dendritic cell
namespace: cell
def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825]
synonym: "DC2" EXACT []
synonym: "interferon-producing cell" EXACT []
synonym: "IPC" EXACT []
synonym: "lymphoid dendritic cell" EXACT []
synonym: "pDC" EXACT []
synonym: "plasmacytoid monocyte" EXACT []
synonym: "plasmacytoid T cell" EXACT []
synonym: "T-associated plasma cell" EXACT []
synonym: "type 2 DC" EXACT []
xref: BTO:0004625
is_a: CL:0000451 {is_inferred="true"} ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: capable_of GO:0032606 ! type I interferon production
relationship: capable_of GO:0032606 ! type I interferon production
relationship: develops_from CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0000785
name: mature B cell
namespace: cell
def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149]
comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive.
synonym: "mature B lymphocyte" EXACT []
synonym: "mature B-cell" EXACT []
synonym: "mature B-lymphocyte" EXACT []
is_a: CL:0000236 {is_inferred="true"} ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: capable_of GO:0042113 ! B cell activation
intersection_of: has_completed GO:0002335 ! mature B cell differentiation
disjoint_from: CL:0000816 ! immature B cell
disjoint_from: CL:0000817 ! precursor B cell
disjoint_from: CL:0000818 ! transitional stage B cell
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0042113 ! B cell activation
relationship: develops_from CL:0000818 ! transitional stage B cell
relationship: has_completed GO:0002335 ! mature B cell differentiation

[Term]
id: CL:0000786
name: plasma cell
namespace: cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740]
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
synonym: "effector B cell" RELATED []
synonym: "effector B-cell" RELATED []
synonym: "plasma B cell" EXACT []
synonym: "plasma B-cell" EXACT []
synonym: "plasmacyte" EXACT []
synonym: "plasmocyte" EXACT []
xref: BTO:0000392
xref: FMA:70574
is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: has_part CP:0000043 ! cartwheel heterochromatin
intersection_of: has_part GO:0005794 ! Golgi apparatus
intersection_of: has_plasma_membrane_part PR:000001935 ! syndecan-1
intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: develops_from CL:0000980 ! plasmablast
relationship: has_part CP:0000043 ! cartwheel heterochromatin
relationship: has_part GO:0005794 ! Golgi apparatus
relationship: has_plasma_membrane_part PR:000001935 ! syndecan-1
relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000787
name: memory B cell
namespace: cell
def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338]
comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive.
synonym: "memory B lymphocyte" EXACT []
synonym: "memory B-cell" EXACT []
synonym: "memory B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_completed GO:0002344 ! B cell affinity maturation
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1
relationship: has_completed GO:0002344 ! B cell affinity maturation
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1

[Term]
id: CL:0000788
name: naive B cell
namespace: cell
def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.
synonym: "naive B lymphocyte" EXACT []
synonym: "naive B-cell" EXACT []
synonym: "naive B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_not_completed GO:0002344 ! B cell affinity maturation
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: develops_from CL:0000818 ! transitional stage B cell
relationship: has_not_completed GO:0002344 ! B cell affinity maturation
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule

[Term]
id: CL:0000789
name: alpha-beta T cell
namespace: cell
def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
disjoint_from: CL:0000798 ! gamma-delta T cell
relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex

[Term]
id: CL:0000790
name: immature alpha-beta T cell
namespace: cell
def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "immature alpha-beta T lymphocyte" EXACT []
synonym: "immature alpha-beta T-cell" EXACT []
synonym: "immature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell
is_a: CL:0002420 ! immature T cell
intersection_of: CL:0000789 ! alpha-beta T cell
intersection_of: has_not_completed GO:0045058 ! T cell selection
relationship: has_not_completed GO:0045058 ! T cell selection

[Term]
id: CL:0000791
name: mature alpha-beta T cell
namespace: cell
def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "mature alpha-beta T lymphocyte" EXACT []
synonym: "mature alpha-beta T-cell" EXACT []
synonym: "mature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0000789 ! alpha-beta T cell
intersection_of: has_completed GO:0045058 ! T cell selection
relationship: develops_from CL:0000790 ! immature alpha-beta T cell
relationship: has_completed GO:0045058 ! T cell selection

[Term]
id: CL:0000792
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'.  The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
synonym: "Treg" BROAD [PMID:22343568]
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
intersection_of: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000793
name: CD4-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0002385 ! mucosal immune response
intersection_of: located_in UBERON:0001277 ! intestinal epithelium
relationship: capable_of GO:0002385 ! mucosal immune response
relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte
relationship: located_in UBERON:0001277 ! intestinal epithelium

[Term]
id: CL:0000794
name: CD8-positive, alpha-beta cytotoxic T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
synonym: "cytotoxic T cell" BROAD []
synonym: "cytotoxic T lymphocyte" BROAD []
synonym: "cytotoxic T-cell" BROAD []
synonym: "cytotoxic T-lymphocyte" BROAD []
synonym: "killer T cell" BROAD []
synonym: "killer T lymphocyte" BROAD []
synonym: "killer T-cell" BROAD []
synonym: "killer T-lymphocyte" BROAD []
xref: CALOHA:TS-0190
xref: FMA:70573
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
is_a: CL:0000910 ! cytotoxic T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity
intersection_of: capable_of GO:0033380 ! granzyme B localization to T cell secretory granule
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_part PR:000003466 ! perforin-1
intersection_of: has_part PR:000003499 ! granzyme B
relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity
relationship: capable_of GO:0033380 ! granzyme B localization to T cell secretory granule
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_part PR:000003466 ! perforin-1
relationship: has_part PR:000003499 ! granzyme B

[Term]
id: CL:0000795
name: CD8-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD8+ regulatory T cell" EXACT []
synonym: "CD8+ T(reg)" EXACT []
synonym: "CD8+ Treg" EXACT []
synonym: "CD8-positive T(reg)" EXACT []
synonym: "CD8-positive Treg" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta Treg" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000796
name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell
intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0000797
name: alpha-beta intraepithelial T cell
namespace: cell
def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "alpha-beta intraepithelial T-cell" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell
is_a: CL:0002496 ! intraepithelial lymphocyte
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: capable_of GO:0002385 ! mucosal immune response
intersection_of: located_in UBERON:0001277 ! intestinal epithelium
relationship: capable_of GO:0002385 ! mucosal immune response
relationship: located_in UBERON:0001277 ! intestinal epithelium

[Term]
id: CL:0000798
name: gamma-delta T cell
namespace: cell
def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
synonym: "gd T cell" RELATED []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex
relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex

[Term]
id: CL:0000799
name: immature gamma-delta T cell
namespace: cell
def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149]
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "immature gamma-delta T lymphocyte" EXACT []
synonym: "immature gamma-delta T-cell" EXACT []
synonym: "immature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell
is_a: CL:0002420 ! immature T cell
intersection_of: CL:0000798 ! gamma-delta T cell
intersection_of: has_not_completed GO:0042492 ! gamma-delta T cell differentiation
intersection_of: has_not_completed GO:0045058 ! T cell selection
relationship: develops_from CL:0000807 ! DN3 thymocyte
relationship: has_not_completed GO:0042492 ! gamma-delta T cell differentiation
relationship: has_not_completed GO:0045058 ! T cell selection

[Term]
id: CL:0000800
name: mature gamma-delta T cell
namespace: cell
def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "mature gamma-delta T lymphocyte" EXACT []
synonym: "mature gamma-delta T-cell" EXACT []
synonym: "mature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell
is_a: CL:0002419 ! mature T cell
intersection_of: CL:0000798 ! gamma-delta T cell
intersection_of: has_completed GO:0045058 ! T cell selection
relationship: develops_from CL:0000799 ! immature gamma-delta T cell
relationship: has_completed GO:0045058 ! T cell selection

[Term]
id: CL:0000801
name: gamma-delta intraepithelial T cell
namespace: cell
def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "gamma-delta intraepithelial T-cell" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell
is_a: CL:0002496 ! intraepithelial lymphocyte
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: capable_of GO:0002385 ! mucosal immune response
intersection_of: located_in UBERON:0001277 ! intestinal epithelium
relationship: capable_of GO:0002385 ! mucosal immune response
relationship: located_in UBERON:0001277 ! intestinal epithelium

[Term]
id: CL:0000802
name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell
namespace: cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell
intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000803
name: CD4-negative CD8-negative gamma-delta intraepithelial T cell
namespace: cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell
intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000805
name: immature single positive thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.
synonym: "immature single positive T cell" EXACT []
synonym: "immature single positive T lymphocyte" EXACT []
synonym: "immature single positive T-lymphocyte" EXACT []
synonym: "ISP" EXACT []
synonym: "T.ISP.th" EXACT []
is_a: CL:0000893 {is_inferred="true"} ! thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0000808 ! DN4 thymocyte
relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000806
name: DN2 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains.
synonym: "DN2 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN2 alpha-beta immature T-cell" EXACT []
synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN2 cell" EXACT []
synonym: "DN2 immature T cell" EXACT []
synonym: "double negative 2" EXACT []
synonym: "preT.DN2.Th" EXACT []
synonym: "TN2 cell" EXACT []
synonym: "TN2 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0000807
name: DN3 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "DN3 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN3 alpha-beta immature T-cell" EXACT []
synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN3 cell" EXACT []
synonym: "DN3 immature T cell" EXACT []
synonym: "double negative 3" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "preT.DN3.Th" EXACT []
synonym: "TN3 cell" EXACT []
synonym: "TN3 thymocyte" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: develops_from CL:0000806 ! DN2 thymocyte
relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0000808
name: DN4 thymocyte
namespace: cell
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
synonym: "DN4 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN4 cell" EXACT []
synonym: "DN4 immature T cell" EXACT []
synonym: "DN4 immature T-cell" EXACT []
synonym: "double negative 4" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "T.DN4.th" EXACT []
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: develops_from CL:0000807 ! DN3 thymocyte
relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0000809
name: double-positive, alpha-beta thymocyte
namespace: cell
def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
comment: Thymocytes of this stage are undergoing positive and negative selection.
synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "DP cell" EXACT []
synonym: "DP thymocyte" EXACT []
synonym: "late cortical thymocyte" BROAD []
is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: part_of UBERON:0002370 ! thymus
relationship: develops_from CL:0000805 ! immature single positive thymocyte
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000810
name: CD4-positive, alpha-beta thymocyte
namespace: cell
def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD4 cell" EXACT []
is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: part_of UBERON:0002370 ! thymus
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000811
name: CD8-positive, alpha-beta thymocyte
namespace: cell
def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta immature T cell" RELATED []
synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD8 cell" EXACT []
is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: part_of UBERON:0002370 ! thymus
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000813
name: memory T cell
namespace: cell
def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
synonym: "memory T lymphocyte" EXACT []
synonym: "memory T-cell" EXACT []
synonym: "memory T-lymphocyte" EXACT []
xref: BTO:0003435
is_a: CL:0002419 {is_inferred="true"} ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
disjoint_from: CL:0000898 ! naive T cell
relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha

[Term]
id: CL:0000814
name: mature NK T cell
namespace: cell
def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149]
synonym: "mature natural killer T cell" EXACT []
synonym: "mature natural killer T lymphocyte" EXACT []
synonym: "mature natural killer T-cell" EXACT []
synonym: "mature natural killer T-lymphocyte" EXACT []
synonym: "mature NK T lymphocyte" EXACT []
synonym: "mature NK T-cell" EXACT []
synonym: "mature NK T-lymphocyte" EXACT []
synonym: "mature NKT cell" EXACT []
is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell
is_a: CL:0002127 ! innate effector T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: capable_of GO:0032394 ! MHC class Ib receptor activity
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: capable_of GO:0032394 ! MHC class Ib receptor activity
relationship: capable_of GO:0045087 ! innate immune response
relationship: develops_from CL:0002042 ! immature NK T cell stage IV
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein

[Term]
id: CL:0000815
name: regulatory T cell
namespace: cell
def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.
synonym: "regulatory T lymphocyte" EXACT []
synonym: "regulatory T-cell" EXACT []
synonym: "regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
xref: BTO:0004520
xref: FMA:84070
is_a: CL:0002419 {is_inferred="true"} ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000816
name: immature B cell
namespace: cell
def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338]
comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.
synonym: "immature B lymphocyte" EXACT []
synonym: "immature B-cell" EXACT []
synonym: "immature B-lymphocyte" EXACT []
synonym: "newly formed B cell" EXACT [ISBN:781735149]
is_a: CL:0000236 ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: has_not_completed GO:0045190 ! isotype switching
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: develops_from CL:0000954 ! small pre-B-II cell
relationship: has_not_completed GO:0045190 ! isotype switching
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0000817
name: precursor B cell
namespace: cell
def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm]
synonym: "pre-B cell" RELATED []
xref: BTO:0001133
xref: CALOHA:TS-0819
is_a: CL:0000236 {is_inferred="true"} ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin
intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
disjoint_from: CL:0000826 ! pro-B cell
relationship: has_plasma_membrane_part PR:000001898 ! neprilysin
relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex

[Term]
id: CL:0000818
name: transitional stage B cell
namespace: cell
def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.
synonym: "T1 B cell" NARROW []
synonym: "T2 B cell" NARROW []
synonym: "T3 B cell" NARROW []
synonym: "transitional B cell" EXACT [PMID:22343568]
synonym: "transitional stage B lymphocyte" EXACT []
synonym: "transitional stage B-cell" EXACT []
synonym: "transitional stage B-lymphocyte" EXACT []
is_a: CL:0000236 {is_inferred="true"} ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_not_completed GO:0002335 ! mature B cell differentiation
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: develops_from CL:0000816 ! immature B cell
relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_not_completed GO:0002335 ! mature B cell differentiation
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000819
name: B-1 B cell
namespace: cell
def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451]
comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low.
synonym: "B-1 B lymphocyte" EXACT []
synonym: "B-1 B-cell" EXACT []
synonym: "B-1 B-lymphocyte" EXACT []
synonym: "B-1 cell" EXACT []
synonym: "B1 B cell" EXACT []
synonym: "B1 B lymphocyte" EXACT []
synonym: "B1 B-cell" EXACT []
synonym: "B1 B-lymphocyte" EXACT []
synonym: "B1 cell" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: capable_of GO:0045087 ! innate immune response
relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin

[Term]
id: CL:0000820
name: B-1a B cell
namespace: cell
def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604]
synonym: "B-1a B lymphocyte" EXACT []
synonym: "B-1a B-cell" EXACT []
synonym: "B-1a B-lymphocyte" EXACT []
synonym: "B1a B cell" EXACT []
synonym: "B1a B lymphocyte" EXACT []
synonym: "B1a B-cell" EXACT []
synonym: "B1a B-lymphocyte" EXACT []
synonym: "B1a cell" EXACT []
synonym: "CD5(+) B1 cell" EXACT []
synonym: "CD5+ B1 cell" EXACT []
synonym: "CD5-positive B1 cell" EXACT []
is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5

[Term]
id: CL:0000821
name: B-1b B cell
namespace: cell
def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604]
synonym: "B-1b B lymphocyte" EXACT []
synonym: "B-1b B-cell" EXACT []
synonym: "B-1b B-lymphocyte" EXACT []
synonym: "B1b B cell" EXACT []
synonym: "B1b B lymphocyte" EXACT []
synonym: "B1b B-cell" EXACT []
synonym: "B1b B-lymphocyte" EXACT []
synonym: "B1b cell" EXACT []
is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5

[Term]
id: CL:0000822
name: B-2 B cell
namespace: cell
def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013]
comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive.
synonym: "B-0 B cell" RELATED []
synonym: "B-2 B lymphocyte" EXACT []
synonym: "B-2 B-cell" EXACT []
synonym: "B-2 B-lymphocyte" EXACT []
synonym: "B2 B cell" EXACT []
synonym: "B2 B lymphocyte" EXACT []
synonym: "B2 B-cell" EXACT []
synonym: "B2 B-lymphocyte" EXACT []
synonym: "B2 cell" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin

[Term]
id: CL:0000823
name: immature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.
synonym: "immature NK cell" EXACT []
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000623 {is_inferred="true"} ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: bearer_of PATO:0001501 ! immature
disjoint_from: CL:0000824 ! mature natural killer cell
disjoint_from: CL:0000937 ! pre-natural killer cell
relationship: bearer_of PATO:0001501 ! immature
relationship: develops_from CL:0000937 ! pre-natural killer cell

[Term]
id: CL:0000824
name: mature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782]
synonym: "LAK cell" BROAD [PMID:14685782]
synonym: "lymphokine activated killer cell" BROAD [PMID:14685782]
synonym: "mature NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell
disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell
relationship: develops_from CL:0000823 ! immature natural killer cell

[Term]
id: CL:0000825
name: pro-NK cell
namespace: cell
def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
comment: Most markers only described for human pro NK cells.
synonym: "natural killer cell progenitor" EXACT []
synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674]
synonym: "null cell" RELATED [PMID:11532393]
synonym: "preNK cell" RELATED [PMID:11532393]
synonym: "pro-natural killer cell" EXACT []
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000001898 ! neprilysin
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor

[Term]
id: CL:0000826
name: pro-B cell
namespace: cell
def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934]
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048]
synonym: "pre-pro B cell" BROAD [PMID:17582343]
synonym: "pro-B lymphocyte" EXACT []
synonym: "pro-B-cell" EXACT []
synonym: "pro-B-lymphocyte" EXACT []
synonym: "progenitor B cell" EXACT []
synonym: "progenitor B lymphocyte" EXACT []
synonym: "progenitor B-cell" EXACT []
synonym: "progenitor B-lymphocyte" EXACT []
xref: BTO:0003104
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: has_part PR:000001903 ! paired box protein PAX-5
intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase
intersection_of: participates_in GO:0033152 ! immunoglobulin V(D)J recombination
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part PR:000001903 ! paired box protein PAX-5
relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase
relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination

[Term]
id: CL:0000827
name: pro-T cell
namespace: cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149]
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: capable_of GO:0030217 ! T cell differentiation
relationship: capable_of GO:0030217 ! T cell differentiation
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000828
name: thromboblast
namespace: cell
def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949]
comment: Note that this is a non-mammalian cell type.
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: bearer_of PATO:0001407 ! mononucleate
intersection_of: capable_of GO:0002574 ! thrombocyte differentiation
relationship: bearer_of PATO:0001407 ! mononucleate
relationship: capable_of GO:0002574 ! thrombocyte differentiation
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000829
name: basophilic myeloblast
namespace: cell
def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464]
is_a: CL:0000835 {is_inferred="true"} ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030221 ! basophil differentiation
relationship: capable_of GO:0030221 ! basophil differentiation
relationship: develops_from CL:0000613 ! basophil progenitor cell

[Term]
id: CL:0000830
name: basophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464]
xref: FMA:84208
is_a: CL:0000836 {is_inferred="true"} ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: capable_of GO:0030221 ! basophil differentiation
relationship: capable_of GO:0030221 ! basophil differentiation
relationship: develops_from CL:0000829 ! basophilic myeloblast

[Term]
id: CL:0000831
name: mast cell progenitor
namespace: cell
def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1183570, PMCID:PMC1312421, PMID:8629001, PMID:9354811]
comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.
synonym: "CFU-Mast " RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0060374 ! mast cell differentiation
intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule
intersection_of: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1
intersection_of: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: capable_of GO:0060374 ! mast cell differentiation
relationship: develops_from CL:0002028 ! basophil mast progenitor cell
relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule
relationship: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1
relationship: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000832
name: eosinophilic myeloblast
namespace: cell
def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464]
is_a: CL:0000835 {is_inferred="true"} ! myeloblast
intersection_of: CL:0000835 ! myeloblast
intersection_of: capable_of GO:0030222 ! eosinophil differentiation
relationship: capable_of GO:0030222 ! eosinophil differentiation
relationship: develops_from CL:0000611 ! eosinophil progenitor cell

[Term]
id: CL:0000833
name: eosinophilic promyelocyte
namespace: cell
def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464]
xref: FMA:84199
is_a: CL:0000836 {is_inferred="true"} ! promyelocyte
intersection_of: CL:0000836 ! promyelocyte
intersection_of: capable_of GO:0030222 ! eosinophil differentiation
relationship: capable_of GO:0030222 ! eosinophil differentiation
relationship: develops_from CL:0000832 ! eosinophilic myeloblast

[Term]
id: CL:0000834
name: neutrophil progenitor cell
namespace: cell
def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464]
synonym: "neutrophil stem cell" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: capable_of GO:0030223 ! neutrophil differentiation
relationship: capable_of GO:0030223 ! neutrophil differentiation
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000835
name: myeloblast
namespace: cell
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464]
xref: BTO:0000187
xref: FMA:83524
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: has_part CP:0000028 ! basophilic cytoplasm
intersection_of: has_part CP:0000037 ! increased nucleus size
intersection_of: has_part GO:0000791 ! euchromatin
intersection_of: lacks_part GO:0042582 ! azurophil granule
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part CP:0000028 ! basophilic cytoplasm
relationship: has_part CP:0000037 ! increased nucleus size
relationship: has_part GO:0000791 ! euchromatin
relationship: lacks_part GO:0042582 ! azurophil granule

[Term]
id: CL:0000836
name: promyelocyte
namespace: cell
def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464]
xref: CALOHA:TS-0825
xref: FMA:83530
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: has_part CP:0000028 ! basophilic cytoplasm
intersection_of: has_part CP:0000037 ! increased nucleus size
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: develops_from CL:0000835 ! myeloblast
relationship: has_part CP:0000028 ! basophilic cytoplasm
relationship: has_part CP:0000037 ! increased nucleus size
relationship: has_part GO:0005730 ! nucleolus
relationship: has_part GO:0042582 ! azurophil granule
relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4
relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24

[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
namespace: cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770]
comment: Markers differ between mouse and human.
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001402 ! multipotent
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: bearer_of PATO:0001402 ! multipotent
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
namespace: cell
def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm]
comment: Note that this is a class of cell types, not an identified single cell type.
synonym: "lymphoid progenitor cell" BROAD []
xref: BTO:0004731
xref: CALOHA:TS-2025
xref: FMA:70338
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0030098 ! lymphocyte differentiation

[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
namespace: cell
def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770]
comment: Note that this is a class of cell types, not an identified single cell type.
synonym: "myeloid progenitor cell" BROAD []
xref: BTO:0004730
xref: CALOHA:TS-2099
xref: FMA:70339
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030099 ! myeloid cell differentiation
relationship: capable_of GO:0030099 ! myeloid cell differentiation

[Term]
id: CL:0000840
name: immature conventional dendritic cell
namespace: cell
def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319]
synonym: "immature myeloid dendritic cell" NARROW []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0000841
name: mature conventional dendritic cell
namespace: cell
def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319]
synonym: "mature dendritic cell" BROAD [GOC:add]
synonym: "mature myeloid dendritic cell" NARROW []
xref: FMA:83038
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0000840 ! immature conventional dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0000842
name: mononuclear cell
namespace: cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "mononuclear leukocyte" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
xref: BTO:0000878
xref: CALOHA:TS-0768
xref: FMA:86713
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0002087 ! nongranular leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: bearer_of PATO:0001407 ! mononucleate
intersection_of: lacks_part GO:0030141 ! secretory granule
relationship: bearer_of PATO:0001407 ! mononucleate
relationship: lacks_part GO:0030141 ! secretory granule

[Term]
id: CL:0000843
name: follicular B cell
namespace: cell
def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013]
comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
synonym: "Fo B cell" EXACT []
synonym: "Fo B-cell" EXACT []
synonym: "follicular B lymphocyte" EXACT []
synonym: "follicular B-cell" EXACT []
synonym: "follicular B-lymphocyte" EXACT []
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin
relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor

[Term]
id: CL:0000844
name: germinal center B cell
namespace: cell
def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013]
comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.
synonym: "GC B cell" EXACT []
synonym: "GC B lymphocyte" EXACT []
synonym: "GC B-cell" EXACT []
synonym: "GC B-lymphocyte" EXACT []
synonym: "germinal center B lymphocyte" EXACT []
synonym: "germinal center B-cell" EXACT []
synonym: "germinal center B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: part_of UBERON:0001745 ! secondary nodular lymphoid tissue
relationship: develops_from CL:0000843 ! follicular B cell
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue

[Term]
id: CL:0000845
name: marginal zone B cell
namespace: cell
def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Marginal-zone_B_cell, ISBN:0781735149, PMID:10933592, PMID:20933013]
comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.
synonym: "marginal zone B lymphocyte" EXACT []
synonym: "marginal zone B-cell" EXACT []
synonym: "marginal zone B-lymphocyte" EXACT []
synonym: "MZ B cell" EXACT []
synonym: "MZ B lymphocyte" EXACT []
synonym: "MZ B-cell" EXACT []
synonym: "MZ B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
is_a: CL:2000074 ! splenocyte
intersection_of: CL:0000785 ! mature B cell
intersection_of: capable_of GO:0042742 ! defense response to bacterium
intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: part_of UBERON:0001251 ! marginal zone of spleen
relationship: capable_of GO:0042742 ! defense response to bacterium
relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000846
name: vestibular dark cell
namespace: cell
def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000847
name: ciliated olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163]
synonym: "ciliated olfactory sensory neuron" EXACT []
synonym: "ciliated sensory neuron" EXACT []
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000207 ! olfactory receptor cell
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0000848
name: microvillous olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163]
synonym: "microvillous olfactory sensory neuron" EXACT []
synonym: "microvillous sensory neuron" RELATED []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000849
name: crypt olfactory receptor neuron
namespace: cell
def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163]
synonym: "crypt cell" EXACT []
synonym: "crypt olfactory sensory neuron" EXACT []
synonym: "crypt sensory neuron" EXACT []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000850
name: serotonergic neuron
namespace: cell
alt_id: CL:0000403
def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl]
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: FBbt:00005133
xref: WBbt:0006837
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission
relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission

[Term]
id: CL:0000851
name: neuromast mantle cell
namespace: cell
def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509]
is_a: CL:0000151 ! secretory cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000852
name: neuromast support cell
namespace: cell
def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509]
is_a: CL:0000630 ! supportive cell
disjoint_from: CL:0000855 ! sensory hair cell
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000853
name: olfactory epithelial support cell
namespace: cell
def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl]
synonym: "olfactory sustentacular cell" EXACT []
synonym: "supporting cell of olfactory epithelium" EXACT []
synonym: "sustentaculocyte of olfactory epithelium" EXACT []
xref: FMA:62302
is_a: CL:0000630 ! supportive cell
is_a: CL:0002169 ! basal cell of olfactory epithelium
intersection_of: CL:0000630 ! supportive cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium
relationship: part_of UBERON:0001997 ! olfactory epithelium

[Term]
id: CL:0000854
name: interneuromast cell
namespace: cell
def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl]
is_a: CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000032 ! neuroplacodal cell

[Term]
id: CL:0000855
name: sensory hair cell
namespace: cell
def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl]
synonym: "hair cell" BROAD []
xref: BTO:0004744
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000856
name: neuromast hair cell
namespace: cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl]
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: part_of UBERON:0008904 ! neuromast
relationship: part_of UBERON:0008904 ! neuromast

[Term]
id: CL:0000857
name: slow muscle myoblast
namespace: cell
def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl]
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000189 ! slow muscle cell
relationship: develops_into CL:0000189 ! slow muscle cell

[Term]
id: CL:0000858
name: fast muscle myoblast
namespace: cell
def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl]
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000190 ! fast muscle cell
relationship: develops_into CL:0000190 ! fast muscle cell

[Term]
id: CL:0000860
name: classical monocyte
namespace: cell
def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168]
comment: Markers: CCR2+CXCCR1 (human, mouse, rat).
synonym: "inflammatory monocyte" EXACT []
is_a: CL:0000234 ! phagocyte
is_a: CL:0000576 {is_inferred="true"} ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: capable_of GO:0002548 ! monocyte chemotaxis
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0006954 ! inflammatory response
intersection_of: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2
intersection_of: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: capable_of GO:0002548 ! monocyte chemotaxis
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0006954 ! inflammatory response
relationship: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2
relationship: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000861
name: elicited macrophage
namespace: cell
def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589]
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).
synonym: "free macrophage" EXACT []
synonym: "wandering histiocyte" EXACT []
xref: FMA:84643
xref: FMA:84645
is_a: CL:0000235 {is_inferred="true"} ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: participates_in GO:0006954 ! inflammatory response
relationship: develops_from CL:0000860 ! classical monocyte
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: participates_in GO:0006954 ! inflammatory response

[Term]
id: CL:0000862
name: suppressor macrophage
namespace: cell
def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419]
comment: Markers: May express: IL10, TGFbeta.
is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0050777 ! negative regulation of immune response

[Term]
id: CL:0000863
name: inflammatory macrophage
namespace: cell
def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917]
comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
synonym: "classically activated macrophage" EXACT []
synonym: "M1 macrophage" RELATED []
is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0032611 ! interleukin-1 beta production
intersection_of: capable_of GO:0032635 ! interleukin-6 production
intersection_of: capable_of GO:0032640 ! tumor necrosis factor production
intersection_of: capable_of GO:0042554 ! superoxide anion generation
intersection_of: capable_of GO:0042742 ! defense response to bacterium
intersection_of: capable_of GO:0051767 ! nitric-oxide synthase biosynthetic process
relationship: capable_of GO:0032611 ! interleukin-1 beta production
relationship: capable_of GO:0032635 ! interleukin-6 production
relationship: capable_of GO:0032640 ! tumor necrosis factor production
relationship: capable_of GO:0042554 ! superoxide anion generation
relationship: capable_of GO:0042742 ! defense response to bacterium
relationship: capable_of GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: CL:0000864
name: tissue-resident macrophage
namespace: cell
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654]
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
xref: FMA:84642
xref: FMA:84644
is_a: CL:0000235 {is_inferred="true"} ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0000479 ! tissue
relationship: part_of UBERON:0000479 ! tissue

[Term]
id: CL:0000865
name: gastrointestinal tract (lamina propria) macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm]
is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: part_of UBERON:0001238 ! lamina propria of small intestine

[Term]
id: CL:0000866
name: thymic macrophage
namespace: cell
def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205]
comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation.
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0043277 ! apoptotic cell clearance
intersection_of: part_of UBERON:0002370 ! thymus
relationship: capable_of GO:0043277 ! apoptotic cell clearance
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000867
name: secondary lymphoid organ macrophage
namespace: cell
def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm]
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000868
name: lymph node macrophage
namespace: cell
def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865]
comment: Marker was observed on rat cells.
synonym: "MF.LN" EXACT []
is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: CL:0000869
name: tonsillar macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540]
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: CL:0000870
name: Peyer's patch macrophage
namespace: cell
def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm]
is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage
intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: part_of UBERON:0001211 ! Peyer's patch

[Term]
id: CL:0000871
name: splenic macrophage
namespace: cell
def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748]
comment: Role or process: immune, clearance of apoptotic and senescent cells.
xref: FMA:83026
is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage
is_a: CL:2000074 ! splenocyte
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: capable_of GO:0034102 ! erythrocyte clearance
intersection_of: part_of UBERON:0002106 ! spleen
relationship: capable_of GO:0034102 ! erythrocyte clearance
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: CL:0000872
name: splenic marginal zone macrophage
namespace: cell
def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066]
comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+.
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A
intersection_of: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO
intersection_of: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II
intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: part_of UBERON:0001251 ! marginal zone of spleen
relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A
relationship: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO
relationship: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II
relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000873
name: splenic metallophillic macrophage
namespace: cell
def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690]
comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+.
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: adjacent_to UBERON:0001959 ! white pulp of spleen
intersection_of: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A
intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin
intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: part_of UBERON:0001251 ! marginal zone of spleen
relationship: adjacent_to UBERON:0001959 ! white pulp of spleen
relationship: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A
relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin
relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: part_of UBERON:0001251 ! marginal zone of spleen

[Term]
id: CL:0000874
name: splenic red pulp macrophage
namespace: cell
def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016]
comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes.
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: capable_of GO:0006955 ! immune response
intersection_of: capable_of GO:0034102 ! erythrocyte clearance
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin
intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: part_of UBERON:0001250 ! red pulp of spleen
relationship: capable_of GO:0006955 ! immune response
relationship: capable_of GO:0034102 ! erythrocyte clearance
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin
relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1
relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: part_of UBERON:0001250 ! red pulp of spleen

[Term]
id: CL:0000875
name: non-classical monocyte
namespace: cell
def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168]
comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-.
synonym: "patrolling monocyte" EXACT []
synonym: "resident monocyte" EXACT []
is_a: CL:0000576 {is_inferred="true"} ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: bearer_of PATO:0000587 ! decreased size
intersection_of: capable_of GO:0031294 ! lymphocyte costimulation
intersection_of: has_completed GO:0030224 ! monocyte differentiation
intersection_of: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: bearer_of PATO:0000587 ! decreased size
relationship: capable_of GO:0031294 ! lymphocyte costimulation
relationship: develops_from CL:0002393 ! intermediate monocyte
relationship: has_completed GO:0030224 ! monocyte differentiation
relationship: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000876
name: splenic white pulp macrophage
namespace: cell
def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597]
comment: Markers: Mouse: F4/80-, CD68+, macrosialin+.
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin
intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: part_of UBERON:0001959 ! white pulp of spleen
relationship: has_plasma_membrane_part PR:000002064 ! macrosialin
relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: part_of UBERON:0001959 ! white pulp of spleen

[Term]
id: CL:0000877
name: splenic tingible body macrophage
namespace: cell
def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584]
is_a: CL:0000876 {is_inferred="true"} ! splenic white pulp macrophage
intersection_of: CL:0000876 ! splenic white pulp macrophage
intersection_of: capable_of GO:0043277 ! apoptotic cell clearance
intersection_of: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer
intersection_of: part_of UBERON:0001249 ! spleen lymphoid follicle
relationship: capable_of GO:0043277 ! apoptotic cell clearance
relationship: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer
relationship: part_of UBERON:0001249 ! spleen lymphoid follicle

[Term]
id: CL:0000878
name: central nervous system macrophage
namespace: cell
def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748]
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000879
name: meningeal macrophage
namespace: cell
def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:11591794]
is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage
intersection_of: CL:0000878 ! central nervous system macrophage
intersection_of: capable_of GO:0005044 ! scavenger receptor activity
intersection_of: part_of UBERON:0002360 ! meninx
relationship: capable_of GO:0005044 ! scavenger receptor activity
relationship: part_of UBERON:0002360 ! meninx

[Term]
id: CL:0000880
name: choroid-plexus macrophage
namespace: cell
def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:9550136]
is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage
intersection_of: CL:0000878 ! central nervous system macrophage
intersection_of: capable_of GO:0005044 ! scavenger receptor activity
intersection_of: located_in UBERON:0001886 ! choroid plexus
relationship: capable_of GO:0005044 ! scavenger receptor activity
relationship: located_in UBERON:0001886 ! choroid plexus

[Term]
id: CL:0000881
name: perivascular macrophage
namespace: cell
def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898]
comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.
is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage
intersection_of: CL:0000878 ! central nervous system macrophage
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: CL:0000882
name: thymic medullary macrophage
namespace: cell
def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205]
is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage
intersection_of: CL:0000866 ! thymic macrophage
intersection_of: part_of UBERON:0002124 ! medulla of thymus
relationship: part_of UBERON:0002124 ! medulla of thymus

[Term]
id: CL:0000883
name: thymic cortical macrophage
namespace: cell
def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205]
is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage
intersection_of: CL:0000866 ! thymic macrophage
intersection_of: part_of UBERON:0002123 ! cortex of thymus
relationship: part_of UBERON:0002123 ! cortex of thymus

[Term]
id: CL:0000884
name: mucosa-associated lymphoid tissue macrophage
namespace: cell
def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191]
is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue
relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue

[Term]
id: CL:0000885
name: gut-associated lymphoid tissue macrophage
namespace: cell
def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191]
is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002387 ! immune response in gut-associated lymphoid tissue
intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue
relationship: capable_of GO:0002387 ! immune response in gut-associated lymphoid tissue
relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue

[Term]
id: CL:0000886
name: nasal and broncial associated lymphoid tissue macrophage
namespace: cell
def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540]
is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage
intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage
intersection_of: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue
relationship: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue

[Term]
id: CL:0000887
name: lymph node subcapsular sinus macrophage
namespace: cell
def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797]
is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage
intersection_of: CL:0000868 ! lymph node macrophage
intersection_of: adjacent_to UBERON:0002194 ! capsule of lymph node
intersection_of: capable_of GO:0032816 ! positive regulation of natural killer cell activation
intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin
relationship: adjacent_to UBERON:0002194 ! capsule of lymph node
relationship: capable_of GO:0032816 ! positive regulation of natural killer cell activation
relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin

[Term]
id: CL:0000888
name: lymph node tingible body macrophage
namespace: cell
def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584]
is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage
intersection_of: CL:0000868 ! lymph node macrophage
intersection_of: capable_of GO:0002905 ! regulation of mature B cell apoptotic process
intersection_of: capable_of GO:0043277 ! apoptotic cell clearance
intersection_of: part_of UBERON:0002006 ! cortex of lymph node
relationship: capable_of GO:0002905 ! regulation of mature B cell apoptotic process
relationship: capable_of GO:0043277 ! apoptotic cell clearance
relationship: part_of UBERON:0002006 ! cortex of lymph node

[Term]
id: CL:0000889
name: myeloid suppressor cell
namespace: cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559]
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: bearer_of PATO:0001501 ! immature
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: bearer_of PATO:0001501 ! immature
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0000890
name: alternatively activated macrophage
namespace: cell
def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870]
comment: Role or process: tissue remodeling.
synonym: "M2 macrophage" RELATED []
is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: capable_of GO:0048771 ! tissue remodeling
intersection_of: has_part PR:000001844 ! arginase-1
relationship: capable_of GO:0048771 ! tissue remodeling
relationship: has_part PR:000001844 ! arginase-1

[Term]
id: CL:0000891
name: foam cell
namespace: cell
def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add]
xref: BTO:0003872
xref: FMA:83586
is_a: CL:0000003 ! native cell

[Term]
id: CL:0000892
name: smooth muscle cell derived foam cell
namespace: cell
def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add]
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000893
name: thymocyte
namespace: cell
def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312]
synonym: "immature T cell" BROAD []
synonym: "immature T lymphocyte" BROAD []
synonym: "immature T-cell" BROAD []
synonym: "immature T-lymphocyte" BROAD []
synonym: "thymic lymphocyte" EXACT []
xref: BTO:0001372
xref: CALOHA:TS-1042
xref: FMA:72202
xref: XAO:0003159
is_a: CL:0002420 {is_inferred="true"} ! immature T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_not_completed GO:0045058 ! T cell selection
intersection_of: part_of UBERON:0002370 ! thymus
relationship: has_not_completed GO:0045058 ! T cell selection
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000894
name: DN1 thymic pro-T cell
namespace: cell
def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm]
synonym: "DN1 thymic pro-T lymphocyte" EXACT []
synonym: "DN1 thymic pro-T-cell" EXACT []
synonym: "DN1 thymic pro-T-lymphocyte" EXACT []
synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
synonym: "double negative 1" EXACT []
synonym: "preT.DN1.Th" EXACT []
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: part_of UBERON:0002370 ! thymus
relationship: develops_from CL:0002425 ! early T lineage precursor
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000895
name: naive thymus-derived CD4-positive, alpha-beta T cell
namespace: cell
def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699, PMID:22343568]
comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells.
synonym: "naive CD4+ T cell" BROAD [PMID:22343568]
synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.4Nve.Sp" EXACT []
synonym: "Th0" EXACT [GOC:tfm]
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte
relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000896
name: activated CD4-positive, alpha-beta T cell
namespace: cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha

[Term]
id: CL:0000897
name: CD4-positive, alpha-beta memory T cell
namespace: cell
def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T4.Mem.Sp" RELATED []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000898
name: naive T cell
namespace: cell
def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699]
synonym: "naive T lymphocyte" EXACT []
synonym: "naive T-cell" EXACT []
synonym: "naive T-lymphocyte" EXACT []
is_a: CL:0002419 {is_inferred="true"} ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: has_completed GO:0045058 ! T cell selection
intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: has_completed GO:0045058 ! T cell selection
relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha

[Term]
id: CL:0000899
name: T-helper 17 cell
namespace: cell
def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells.
synonym: "helper T cell type 17" EXACT []
synonym: "IL-17-producing CD4+ T helper" EXACT []
synonym: "T helper cells type 17" EXACT []
synonym: "T(H)-17 cell" EXACT []
synonym: "Th17 CD4+ T cell" EXACT [PMID:22343568]
synonym: "Th17 cell" EXACT []
synonym: "Th17 T cell" EXACT []
synonym: "Th17 T lymphocyte" EXACT []
synonym: "Th17 T-cell" EXACT []
synonym: "Th17 T-lymphocyte" EXACT []
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0032620 ! interleukin-17 production
intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: capable_of GO:0032620 ! interleukin-17 production
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0000900
name: naive thymus-derived CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:22343568]
comment: This cell traffics in secondary lymphoid organs and blood.  This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells.
synonym: "naive CD8+ T cell" BROAD [PMID:22343568]
synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT []
synonym: "T.8Nve.Sp" NARROW []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte
relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000901
name: Tr1 cell
namespace: cell
def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam, PMID:16903904]
comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.)
synonym: "T-regulatory T cell type 1" EXACT []
synonym: "Tr1 T cell" EXACT []
synonym: "Tr1 T lymphocyte" EXACT []
synonym: "Tr1 T-cell" EXACT []
synonym: "Tr1 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
is_a: CL:0000815 ! regulatory T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0032613 ! interleukin-10 production
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
relationship: capable_of GO:0032613 ! interleukin-10 production
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000902
name: induced T-regulatory cell
namespace: cell
def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985]
synonym: "adaptive Treg" RELATED []
synonym: "aTreg" RELATED []
synonym: "induced regulatory T cell" EXACT []
synonym: "induced regulatory T lymphocyte" EXACT []
synonym: "induced regulatory T-cell" EXACT []
synonym: "induced regulatory T-lymphocyte" EXACT []
synonym: "induced Treg" EXACT []
synonym: "iTreg" EXACT []
is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
intersection_of: has_part PR:000001350 ! forkhead box protein P3
intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000001350 ! forkhead box protein P3
relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4

[Term]
id: CL:0000903
name: natural T-regulatory cell
namespace: cell
def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985]
synonym: "natural regulatory T cell" EXACT []
synonym: "natural regulatory T lymphocyte" EXACT []
synonym: "natural regulatory T-cell" EXACT []
synonym: "natural regulatory T-lymphocyte" EXACT []
synonym: "natural Treg" EXACT []
synonym: "nTreg" EXACT []
is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: has_part PR:000001350 ! forkhead box protein P3
intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000001350 ! forkhead box protein P3
relationship: has_plasma_membrane_part PR:000001318 ! L-selectin
relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4

[Term]
id: CL:0000904
name: central memory CD4-positive, alpha-beta T cell
namespace: cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells.
synonym: "central CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD4+ T cell" BROAD [PMID:22343568]
synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell
intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell
intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000905
name: effector memory CD4-positive, alpha-beta T cell
namespace: cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells.
synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD4+ T cell" BROAD [PMID:22343568]
synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell
intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000906
name: activated CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha

[Term]
id: CL:0000907
name: central memory CD8-positive, alpha-beta T cell
namespace: cell
def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells.
synonym: "central CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD8+ T cell" BROAD [PMID:22343568]
synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell
intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell
intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000908
name: CD8-positive, alpha-beta cytokine secreting effector T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: capable_of GO:0001816 ! cytokine production
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha

[Term]
id: CL:0000909
name: CD8-positive, alpha-beta memory T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:tfm, PMID:20146720]
synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "T.8Mem.Sp" EXACT []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000910
name: cytotoxic T cell
namespace: cell
def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547]
synonym: "cytotoxic T lymphocyte" EXACT []
synonym: "cytotoxic T-cell" EXACT []
synonym: "cytotoxic T-lymphocyte" EXACT []
xref: BTO:0000289
xref: CALOHA:TS-0190
xref: FMA:70573
is_a: CL:0000911 {is_inferred="true"} ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity
relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: CL:0000911
name: effector T cell
namespace: cell
def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547]
synonym: "effector T lymphocyte" EXACT []
synonym: "effector T-cell" EXACT []
synonym: "effector T-lymphocyte" EXACT []
is_a: CL:0002419 {is_inferred="true"} ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_completed GO:0045058 ! T cell selection
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_completed GO:0045058 ! T cell selection

[Term]
id: CL:0000912
name: helper T cell
namespace: cell
def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547]
synonym: "helper T lymphocyte" EXACT []
synonym: "helper T-cell" EXACT []
synonym: "helper T-lymphocyte" EXACT []
synonym: "T-helper cell" EXACT []
xref: BTO:0002417
is_a: CL:0000911 {is_inferred="true"} ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0001816 ! cytokine production

[Term]
id: CL:0000913
name: effector memory CD8-positive, alpha-beta T cell
namespace: cell
def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells.
synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD8+ T cell" BROAD [PMID:22343568]
synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell
intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000914
name: immature NK T cell
namespace: cell
def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262]
synonym: "immature NK T lymphocyte" EXACT []
synonym: "immature NK T-cell" EXACT []
synonym: "immature NK T-lymphocyte" EXACT []
synonym: "immature NKT cell" EXACT []
is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell
intersection_of: CL:0000790 ! immature alpha-beta T cell
intersection_of: has_part PR:000003469 ! early growth response protein 2
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_part PR:000003469 ! early growth response protein 2

[Term]
id: CL:0000915
name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell
namespace: cell
def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222]
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell
intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5

[Term]
id: CL:0000916
name: dendritic epidermal T cell
namespace: cell
def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459]
comment: In mice, DETC have an invariant T cell receptor.
synonym: "dendritic epidermal T lymphocyte" EXACT []
synonym: "dendritic epidermal T-cell" EXACT []
synonym: "dendritic epidermal T-lymphocyte" EXACT []
synonym: "DETC" EXACT []
is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing
intersection_of: located_in UBERON:0001003 ! skin epidermis
relationship: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing
relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor
relationship: located_in UBERON:0001003 ! skin epidermis

[Term]
id: CL:0000917
name: Tc1 cell
namespace: cell
def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568, PMID:9914231]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells.
synonym: "T-cytotoxic T cell type 1" EXACT []
synonym: "Tc1 CD8+ T cell" EXACT [PMID:22343568]
synonym: "Tc1 T cell" EXACT []
synonym: "Tc1 T lymphocyte" EXACT []
synonym: "Tc1 T-cell" EXACT []
synonym: "Tc1 T-lymphocyte" EXACT []
xref: BTO:0004793
xref: BTO:0004888
xref: FMA:84793
is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21
intersection_of: has_part PR:000003463 ! eomesodermin
intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: has_part PR:000001835 ! T-box transcription factor TBX21
relationship: has_part PR:000003463 ! eomesodermin
relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6

[Term]
id: CL:0000918
name: Tc2 cell
namespace: cell
def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell.
synonym: "T-cytotoxic T cell type 2" EXACT []
synonym: "Tc2 T cell" EXACT []
synonym: "Tc2 T lymphocyte" EXACT []
synonym: "Tc2 T-cell" EXACT []
synonym: "Tc2 T-lymphocyte" EXACT []
xref: BTO:0004794
xref: FMA:84794
is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell
is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0000919
name: CD8-positive, CD25-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505]
synonym: "CD8+CD25+ T cell" EXACT []
synonym: "CD8+CD25+ T lymphocyte" EXACT []
synonym: "CD8+CD25+ T(reg)" EXACT []
synonym: "CD8+CD25+ T-cell" EXACT []
synonym: "CD8+CD25+ T-lymphocyte " EXACT []
synonym: "CD8+CD25+ Treg" EXACT []
synonym: "CD8-positive, CD25-positive Treg" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell
intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: has_part PR:000001350 ! forkhead box protein P3
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001350 ! forkhead box protein P3
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha

[Term]
id: CL:0000920
name: CD8-positive, CD28-negative, alpha-beta regulatory T cell
namespace: cell
def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505]
synonym: "CD8+CD28- T cell" EXACT []
synonym: "CD8+CD28- T lymphocyte" EXACT []
synonym: "CD8+CD28- T(reg)" EXACT []
synonym: "CD8+CD28- T-cell" EXACT []
synonym: "CD8+CD28- T-lymphocyte " EXACT []
synonym: "CD8+CD28- Treg" EXACT []
synonym: "CD8-positive, CD28-negative T(reg)" EXACT []
synonym: "CD8-positive, CD28-negative Treg" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell
intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: has_part PR:000001350 ! forkhead box protein P3
intersection_of: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell
relationship: has_part PR:000001350 ! forkhead box protein P3
relationship: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28

[Term]
id: CL:0000921
name: type I NK T cell
namespace: cell
def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760]
comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24.
synonym: "classical NK T cell" EXACT []
synonym: "invariant NK T cell" RELATED []
synonym: "type I NK T lymphocyte" EXACT []
synonym: "type I NK T-cell" EXACT []
synonym: "type I NK T-lymphocyte" EXACT []
synonym: "type I NKT cell" EXACT []
is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: capable_of GO:0043208 ! glycosphingolipid binding
relationship: capable_of GO:0043208 ! glycosphingolipid binding

[Term]
id: CL:0000922
name: type II NK T cell
namespace: cell
def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760]
synonym: "type II NK T lymphocyte" EXACT []
synonym: "type II NK T-cell" EXACT []
synonym: "type II NK T-lymphocyte" EXACT []
synonym: "type II NKT cell" EXACT []
is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell
intersection_of: CL:0000814 ! mature NK T cell
intersection_of: capable_of GO:0002288 ! NK T cell activation involved in immune response
relationship: capable_of GO:0002288 ! NK T cell activation involved in immune response

[Term]
id: CL:0000923
name: CD4-positive type I NK T cell
namespace: cell
def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "CD4-positive type I NK T lymphocyte" EXACT []
synonym: "CD4-positive type I NK T-cell" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "CD4-positive type I NKT cell" EXACT []
synonym: "NKT.4+.SP" NARROW []
is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule

[Term]
id: CL:0000924
name: CD4-negative, CD8-negative type I NK T cell
namespace: cell
def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862]
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT []
synonym: "NKT.4-.Sp" NARROW []
is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000925
name: activated CD4-positive type I NK T cell
namespace: cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "activated CD4-positive type I NK T lymphocyte" EXACT []
synonym: "activated CD4-positive type I NK T-cell" EXACT []
synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-positive type I NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule

[Term]
id: CL:0000926
name: CD4-positive type I NK T cell secreting interferon-gamma
namespace: cell
def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule

[Term]
id: CL:0000927
name: CD4-positive type I NK T cell secreting interleukin-4
namespace: cell
def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000923 ! CD4-positive type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
intersection_of: capable_of GO:0032616 ! interleukin-13 production
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response
relationship: capable_of GO:0032616 ! interleukin-13 production
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule

[Term]
id: CL:0000928
name: activated CD4-negative, CD8-negative type I NK T cell
namespace: cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0002369 ! T cell cytokine production
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0002369 ! T cell cytokine production
relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000929
name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma
namespace: cell
def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000930
name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4
namespace: cell
def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398]
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell
intersection_of: CL:0000921 ! type I NK T cell
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000931
name: activated type II NK T cell
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217]
synonym: "activated type II NK T lymphocyte" EXACT []
synonym: "activated type II NK T-cell" EXACT []
synonym: "activated type II NK T-lymphocyte" EXACT []
synonym: "activated type II NKT cell" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: capable_of GO:0002369 ! T cell cytokine production
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: capable_of GO:0002369 ! T cell cytokine production
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule

[Term]
id: CL:0000932
name: type II NK T cell secreting interferon-gamma
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217]
synonym: "type II NK T cell secreting IFN-gamma" EXACT []
synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NK T-cell secreting interferon-gamma" EXACT []
synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0000931 ! activated type II NK T cell
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule

[Term]
id: CL:0000933
name: type II NK T cell secreting interleukin-4
namespace: cell
def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217]
synonym: "type II NK T cell secreting IL-4" EXACT []
synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NK T-cell secreting interleukin-4" EXACT []
synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000912 ! helper T cell
is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell
intersection_of: CL:0000922 ! type II NK T cell
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: develops_from CL:0000931 ! activated type II NK T cell
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule

[Term]
id: CL:0000934
name: CD4-positive, alpha-beta cytotoxic T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213]
synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
is_a: CL:0000910 ! cytotoxic T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity
intersection_of: has_completed GO:0030217 ! T cell differentiation
relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_completed GO:0030217 ! T cell differentiation

[Term]
id: CL:0000935
name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell
namespace: cell
def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222]
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell
intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1

[Term]
id: CL:0000936
name: early lymphoid progenitor
namespace: cell
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.
synonym: "ELP" EXACT []
synonym: "GMLP" RELATED [PMID:18371378]
synonym: "LMPP" EXACT []
synonym: "lymphoid-primed multipotent progenitor" EXACT []
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: capable_of GO:0030098 ! lymphocyte differentiation
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A

[Term]
id: CL:0000937
name: pre-natural killer cell
namespace: cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874]
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
synonym: "pre-NK cell" EXACT []
is_a: CL:0000623 {is_inferred="true"} ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell
disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor

[Term]
id: CL:0000938
name: CD16-negative, CD56-bright natural killer cell
namespace: cell
def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types.
synonym: "CD16-CD56bright NK cell" EXACT [PMID:22343568]
synonym: "CD16-negative, CD56-bright NK cell" EXACT []
synonym: "CD56-bright cytokine secreting natural killer cell" EXACT []
synonym: "CD56-bright cytokine secreting NK cell" EXACT []
is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
intersection_of: has_plasma_membrane_part PR:000001319 ! SLAM family member 5
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
disjoint_from: CL:0000939 ! CD16-positive, CD56-dim natural killer cell
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
relationship: has_plasma_membrane_part PR:000001319 ! SLAM family member 5
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0000939
name: CD16-positive, CD56-dim natural killer cell
namespace: cell
def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types.
synonym: "CD16+CD56+ NK cell" EXACT [PMID:22343568]
synonym: "CD16-positive, CD56-dim NK cell" EXACT []
synonym: "CD16-positive, CD56-low natural killer cell" EXACT []
synonym: "CD16-positive, CD56-low NK cell" EXACT []
synonym: "CD16-positive, CD56-positive natural killer cell" EXACT []
synonym: "CD16-positive, CD56-positive NK cell" EXACT []
synonym: "cytotoxic CD56-dim natural killer cell" EXACT []
synonym: "cytotoxic CD56-dim NK cell" EXACT []
is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0042267 ! natural killer cell mediated cytotoxicity
intersection_of: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0042267 ! natural killer cell mediated cytotoxicity
relationship: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0000940
name: mucosal invariant T cell
namespace: cell
def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870]
synonym: "mucosal invariant T lymphocyte" EXACT []
synonym: "mucosal invariant T-cell" EXACT []
synonym: "mucosal invariant T-lymphocyte" EXACT []
is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell
is_a: CL:0002127 ! innate effector T cell
intersection_of: CL:0000791 ! mature alpha-beta T cell
intersection_of: capable_of GO:0002227 ! innate immune response in mucosa
intersection_of: capable_of GO:0032394 ! MHC class Ib receptor activity
intersection_of: has_completed GO:0030217 ! T cell differentiation
relationship: capable_of GO:0002227 ! innate immune response in mucosa
relationship: capable_of GO:0032394 ! MHC class Ib receptor activity
relationship: has_completed GO:0030217 ! T cell differentiation

[Term]
id: CL:0000941
name: thymic conventional dendritic cell
namespace: cell
def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629]
comment: In the mouse this cell expresses CD8-alpha-alpha.
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: part_of UBERON:0002370 ! thymus
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: CL:0000942
name: thymic plasmacytoid dendritic cell
namespace: cell
def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119]
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0000943
name: Be1 Cell
namespace: cell
def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569]
comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive.
synonym: "B effector 1 cell" EXACT [PMID:11101868, PMID:20224569]
synonym: "B effector cell type 1" RELATED []
is_a: CL:0000968 {is_inferred="true"} ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: capable_of GO:0032623 ! interleukin-2 production
intersection_of: capable_of GO:0032640 ! tumor necrosis factor production
intersection_of: capable_of GO:0045627 ! positive regulation of T-helper 1 cell differentiation
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: capable_of GO:0032623 ! interleukin-2 production
relationship: capable_of GO:0032640 ! tumor necrosis factor production
relationship: capable_of GO:0045627 ! positive regulation of T-helper 1 cell differentiation

[Term]
id: CL:0000944
name: Be2 cell
namespace: cell
def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569]
comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive.
synonym: "B effector 2 cell" EXACT [PMID:11101868, PMID:20224569]
synonym: "B effector cell type 2" RELATED []
is_a: CL:0000968 {is_inferred="true"} ! Be cell
intersection_of: CL:0000968 ! Be cell
intersection_of: capable_of GO:0032613 ! interleukin-10 production
intersection_of: capable_of GO:0032623 ! interleukin-2 production
intersection_of: capable_of GO:0032633 ! interleukin-4 production
intersection_of: capable_of GO:0032635 ! interleukin-6 production
intersection_of: capable_of GO:0045630 ! positive regulation of T-helper 2 cell differentiation
relationship: capable_of GO:0032613 ! interleukin-10 production
relationship: capable_of GO:0032623 ! interleukin-2 production
relationship: capable_of GO:0032633 ! interleukin-4 production
relationship: capable_of GO:0032635 ! interleukin-6 production
relationship: capable_of GO:0045630 ! positive regulation of T-helper 2 cell differentiation

[Term]
id: CL:0000945
name: lymphocyte of B lineage
namespace: cell
def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells).  Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: develops_from CL:0000826 ! pro-B cell
relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon

[Term]
id: CL:0000946
name: antibody secreting cell
namespace: cell
def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149]
is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating
relationship: produces GO:0042571 ! immunoglobulin complex, circulating

[Term]
id: CL:0000947
name: IgE plasma cell
namespace: cell
def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating
relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating

[Term]
id: CL:0000948
name: IgE memory B cell
namespace: cell
def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196]
synonym: "IgE memory B lymphocyte" EXACT []
synonym: "IgE memory B-cell" EXACT []
synonym: "IgE memory B-lymphocyte" EXACT []
synonym: "memory IgE B cell" EXACT []
synonym: "memory IgE B lymphocyte" EXACT []
synonym: "memory IgE B-cell" EXACT []
synonym: "memory IgE B-lymphocyte" EXACT []
is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex

[Term]
id: CL:0000949
name: IgD plasmablast
namespace: cell
def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 {is_inferred="true"} ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: produces GO:0071739 ! IgD immunoglobulin complex, circulating
relationship: produces GO:0071739 ! IgD immunoglobulin complex, circulating

[Term]
id: CL:0000950
name: IgE plasmablast
namespace: cell
def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 {is_inferred="true"} ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating
relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating

[Term]
id: CL:0000951
name: IgE short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating
relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating

[Term]
id: CL:0000952
name: preBCR-positive large pre-B-II cell
namespace: cell
def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673]
is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1

[Term]
id: CL:0000953
name: preBCR-negative large pre-B-II cell
namespace: cell
def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673]
is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
intersection_of: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
intersection_of: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
relationship: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1

[Term]
id: CL:0000954
name: small pre-B-II cell
namespace: cell
def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673]
comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
synonym: "small pre-BII cell" EXACT []
is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2
intersection_of: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex
intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
intersection_of: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination
relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex
relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination

[Term]
id: CL:0000955
name: pre-B-II cell
namespace: cell
def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673]
comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive.
synonym: "pre-B-lymphocyte" EXACT []
synonym: "pre-BII cell" EXACT []
xref: BTO:0001133
xref: CALOHA:TS-0819
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
intersection_of: lacks_part PR:000006611 ! DNA nucleotidylexotransferase
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
disjoint_from: CL:0000956 ! pre-B-I cell
relationship: develops_from CL:0000826 ! pro-B cell
relationship: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
relationship: lacks_part PR:000006611 ! DNA nucleotidylexotransferase
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule

[Term]
id: CL:0000956
name: pre-B-I cell
namespace: cell
def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673]
comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive.
synonym: "pre-BI cell" EXACT []
synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048]
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2
intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
relationship: develops_from CL:0000826 ! pro-B cell
relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain
relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination

[Term]
id: CL:0000957
name: large pre-B-II cell
namespace: cell
def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673]
comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
synonym: "large pre-B cell" BROAD [PMID:11244048]
synonym: "large pre-BII cell" EXACT []
is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2
intersection_of: participates_in GO:0046651 ! lymphocyte proliferation
relationship: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: participates_in GO:0046651 ! lymphocyte proliferation

[Term]
id: CL:0000958
name: T1 B cell
namespace: cell
def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111]
comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive.
synonym: "T1 B lymphocyte" EXACT []
synonym: "T1 B-cell" EXACT []
synonym: "T1 B-lymphocyte" EXACT []
synonym: "transitional stage 1 B cell" EXACT []
is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin
relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor

[Term]
id: CL:0000959
name: T2 B cell
namespace: cell
def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111]
comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive.
synonym: "T2 B lymphocyte" EXACT []
synonym: "T2 B-cell" EXACT []
synonym: "T2 B-lymphocyte" EXACT []
synonym: "transitional stage 2 B cell" EXACT []
is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin
relationship: develops_from CL:0000958 ! T1 B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin

[Term]
id: CL:0000960
name: T3 B cell
namespace: cell
def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121]
synonym: "An1 B cell" EXACT [PMID:17174121]
synonym: "T3 B lymphocyte" EXACT []
synonym: "T3 B-cell" EXACT []
synonym: "T3 B-lymphocyte" EXACT []
synonym: "transitional stage 3 B cell" EXACT []
is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell
intersection_of: CL:0000818 ! transitional stage B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
intersection_of: participates_in GO:0002515 ! B cell anergy
relationship: develops_from CL:0000959 ! T2 B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001318 ! L-selectin
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: participates_in GO:0002515 ! B cell anergy

[Term]
id: CL:0000961
name: Bm1 B cell
namespace: cell
def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591]
comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm1 B lymphocyte" EXACT []
synonym: "Bm1 B-cell" EXACT []
synonym: "Bm1 B-lymphocyte" EXACT []
is_a: CL:0000843 {is_inferred="true"} ! follicular B cell
is_a: CL:0002056 ! Fraction F mature B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: develops_from CL:0000818 ! transitional stage B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor

[Term]
id: CL:0000962
name: Bm2 B cell
namespace: cell
def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591]
comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2 B lymphocyte" EXACT []
synonym: "Bm2 B-cell" EXACT []
synonym: "Bm2 B-lymphocyte" EXACT []
is_a: CL:0000843 {is_inferred="true"} ! follicular B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: develops_from CL:0000961 ! Bm1 B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor

[Term]
id: CL:0000963
name: Bm3-delta B cell
namespace: cell
def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752]
synonym: "Bm3-delta B lymphocyte" EXACT []
synonym: "Bm3-delta B-cell" EXACT []
synonym: "Bm3-delta B-lymphocyte" EXACT []
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: develops_from CL:0000965 ! Bm3 B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex

[Term]
id: CL:0000964
name: Bm2' B cell
namespace: cell
def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:17992590, PMID:18432934, PMID:8006591]
comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2' B lymphocyte" EXACT []
synonym: "Bm2' B-cell" EXACT []
synonym: "Bm2' B-lymphocyte" EXACT []
synonym: "Bm2-prime B cell" EXACT []
synonym: "Bm2-prime B lymphocyte " EXACT []
synonym: "Bm2-prime B-cell " EXACT []
synonym: "Bm2-prime B-lymphocyte " EXACT []
synonym: "germinal center founder cell" RELATED []
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: capable_of GO:0002634 ! regulation of germinal center formation
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: capable_of GO:0002634 ! regulation of germinal center formation
relationship: develops_from CL:0000962 ! Bm2 B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor

[Term]
id: CL:0000965
name: Bm3 B cell
namespace: cell
def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591]
comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive.
synonym: "Bm3 B lymphocyte" EXACT []
synonym: "Bm3 B-cell" EXACT []
synonym: "Bm3 B-lymphocyte" EXACT []
synonym: "centroblast" RELATED [PMID:8006591]
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: develops_from CL:0000964 ! Bm2' B cell
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0000966
name: Bm4 B cell
namespace: cell
def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591]
comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive.
synonym: "Bm4 B lymphocyte" EXACT []
synonym: "Bm4 B-cell" EXACT []
synonym: "Bm4 B-lymphocyte" EXACT []
synonym: "centrocyte" RELATED [PMID:17992590]
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase
relationship: develops_from CL:0000963 ! Bm3-delta B cell
relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase

[Term]
id: CL:0000967
name: Bm5 B cell
namespace: cell
def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:18432934, PMID:8006591]
comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative.
synonym: "Bm5 B lymphocyte" EXACT []
synonym: "Bm5 B-cell" EXACT []
synonym: "Bm5 B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: has_completed GO:0002314 ! germinal center B cell differentiation
intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: develops_from CL:0000966 ! Bm4 B cell
relationship: has_completed GO:0002314 ! germinal center B cell differentiation
relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0000968
name: Be cell
namespace: cell
def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569]
synonym: "B effector cell" EXACT []
synonym: "effector B cell" EXACT []
synonym: "effector B lymphocyte" EXACT []
synonym: "effector B-cell" EXACT []
synonym: "effector B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0000969
name: regulatory B cell
namespace: cell
def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, MESH:D060151, PMID:11869683, PMID:18482568, PMID:20224569, PMID:20809522]
comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive.
synonym: "B(reg)" EXACT []
synonym: "B10 cell" EXACT []
synonym: "Breg" EXACT []
synonym: "regulatory B lymphocyte" EXACT []
synonym: "regulatory B-cell" EXACT []
synonym: "regulatory B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: capable_of GO:0032613 ! interleukin-10 production
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000002028 ! antigen-presenting glycoprotein CD1d
relationship: capable_of GO:0032613 ! interleukin-10 production
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000002028 ! antigen-presenting glycoprotein CD1d

[Term]
id: CL:0000970
name: unswitched memory B cell
namespace: cell
def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
synonym: "IgD+ memory B cell" BROAD [PMID:22343568]
synonym: "unswitched memory B lymphocyte" EXACT []
synonym: "unswitched memory B-cell" EXACT []
synonym: "unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000787 {is_inferred="true"} ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
intersection_of: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex
intersection_of: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1
relationship: develops_from CL:0000980 ! plasmablast
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1

[Term]
id: CL:0000971
name: IgM memory B cell
namespace: cell
def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676]
comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive.
synonym: "IgM memory B lymphocyte" EXACT []
synonym: "IgM memory B-cell" EXACT []
synonym: "IgM memory B-lymphocyte" EXACT []
synonym: "memory IgM B cell" EXACT []
synonym: "memory IgM B lymphocyte" EXACT []
synonym: "memory IgM B-cell" EXACT []
synonym: "memory IgM B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0000972
name: class switched memory B cell
namespace: cell
def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:9295047]
comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive.
synonym: "class switched memory B lymphocyte" EXACT []
synonym: "class switched memory B-cell" EXACT []
synonym: "class switched memory B-lymphocyte" EXACT []
is_a: CL:0000787 {is_inferred="true"} ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: has_completed GO:0045190 ! isotype switching
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: develops_from CL:0000970 ! unswitched memory B cell
relationship: has_completed GO:0045190 ! isotype switching
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex

[Term]
id: CL:0000973
name: IgA memory B cell
namespace: cell
def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196]
comment: IgA memory B cell are also reportedly RORalpha-positive.
synonym: "IgA memory B lymphocyte" EXACT []
synonym: "IgA memory B-cell" EXACT []
synonym: "IgA memory B-lymphocyte" EXACT []
synonym: "memory IgA B cell" EXACT []
synonym: "memory IgA B lymphocyte" EXACT []
synonym: "memory IgA B-cell" EXACT []
synonym: "memory IgA B-lymphocyte" EXACT []
is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex

[Term]
id: CL:0000974
name: long lived plasma cell
namespace: cell
def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527]
is_a: CL:0000786 {is_inferred="true"} ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4
intersection_of: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1
intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: develops_from CL:0000975 ! short lived plasma cell
relationship: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4
relationship: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1
relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0000975
name: short lived plasma cell
namespace: cell
def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527]
is_a: CL:0000786 {is_inferred="true"} ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: bearer_of PATO:0001604 ! decreased life span
relationship: bearer_of PATO:0001604 ! decreased life span
relationship: develops_from CL:0000980 ! plasmablast

[Term]
id: CL:0000976
name: IgA short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating
relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating

[Term]
id: CL:0000977
name: IgG short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating
relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating

[Term]
id: CL:0000978
name: IgM short lived plasma cell
namespace: cell
def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell
intersection_of: CL:0000975 ! short lived plasma cell
intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating
relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating

[Term]
id: CL:0000979
name: IgG memory B cell
namespace: cell
def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196]
synonym: "IgG memory B lymphocyte" EXACT []
synonym: "IgG memory B-cell" EXACT []
synonym: "IgG memory B-lymphocyte" EXACT []
synonym: "memory IgG B cell" EXACT []
synonym: "memory IgG B lymphocyte" EXACT []
synonym: "memory IgG B-cell" EXACT []
synonym: "memory IgG B-lymphocyte" EXACT []
is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex

[Term]
id: CL:0000980
name: plasmablast
namespace: cell
def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.
xref: FMA:84371
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
is_a: CL:0000946 ! antibody secreting cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1
intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating
relationship: develops_from CL:0000785 ! mature B cell
relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1
relationship: produces GO:0042571 ! immunoglobulin complex, circulating

[Term]
id: CL:0000981
name: double negative memory B cell
namespace: cell
def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm]
synonym: "dn memory B cell" EXACT []
synonym: "dn memory B lymphocyte" EXACT []
synonym: "dn memory B-cell" EXACT []
synonym: "dn memory B-lymphocyte" EXACT []
synonym: "double negative memory B lymphocyte" EXACT []
synonym: "double negative memory B-cell" EXACT []
synonym: "double negative memory B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule

[Term]
id: CL:0000982
name: IgG plasmablast
namespace: cell
def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 {is_inferred="true"} ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating
relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating

[Term]
id: CL:0000983
name: IgM plasmablast
namespace: cell
def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 {is_inferred="true"} ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating
relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating

[Term]
id: CL:0000984
name: IgA plasmablast
namespace: cell
def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 {is_inferred="true"} ! plasmablast
intersection_of: CL:0000980 ! plasmablast
intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating
relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating

[Term]
id: CL:0000985
name: IgG plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating
relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating

[Term]
id: CL:0000986
name: IgM plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating
relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating

[Term]
id: CL:0000987
name: IgA plasma cell
namespace: cell
def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149]
is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell
intersection_of: CL:0000974 ! long lived plasma cell
intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating
relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating

[Term]
id: CL:0000988
name: hematopoietic cell
namespace: cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
xref: BTO:0000574
xref: CALOHA:TS-2017
xref: FMA:70366
xref: FMA:83598
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000989
name: CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8).
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0000990
name: conventional dendritic cell
namespace: cell
def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.
synonym: "cDC" EXACT []
synonym: "DC1" EXACT []
synonym: "dendritic reticular cell" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
is_a: CL:0000451 {is_inferred="true"} ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X
relationship: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X

[Term]
id: CL:0000991
name: CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10).
synonym: "CD303-positive dendritic cell" EXACT []
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0032606 ! type I interferon production
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C
intersection_of: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0032606 ! type I interferon production
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C
relationship: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain

[Term]
id: CL:0000992
name: immature CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617).
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0000993
name: mature CD11c-low plasmacytoid dendritic cell
namespace: cell
def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617).
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0000994
name: immature CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617).
is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell
intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule

[Term]
id: CL:0000995
name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD []
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor

[Term]
id: CL:0000996
name: mature CD11c-negative plasmacytoid dendritic cell
namespace: cell
def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617).
is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell
intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0000997
name: immature CD8_alpha-negative CD11b-positive dendritic cell
namespace: cell
def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell
intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0000998
name: CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, http:www.immgen.org/index_content.html, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617).
synonym: "DC.8-4-11b-" EXACT []
synonym: "triple negative dendritic cell" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: capable_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0000999
name: CD4-positive CD11b-positive dendritic cell
namespace: cell
def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617).
synonym: "DC.4+" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0050728 ! negative regulation of inflammatory response
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0050728 ! negative regulation of inflammatory response
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0001000
name: CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617).
synonym: "DC.8+" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I
intersection_of: capable_of GO:0050729 ! positive regulation of inflammatory response
intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I
relationship: capable_of GO:0050729 ! positive regulation of inflammatory response
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M

[Term]
id: CL:0001001
name: immature CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001002
name: mature CD8_alpha-negative CD11b-negative dendritic cell
namespace: cell
def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: capable_of GO:0001816 ! cytokine production
relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001003
name: mature CD8_alpha-negative CD11b-positive dendritic cell
namespace: cell
def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell
intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001004
name: immature CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001005
name: mature CD8_alpha-positive CD11b-negative dendritic cell
namespace: cell
def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001006
name: dermal dendritic cell
namespace: cell
def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9).
xref: BTO:0004812
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: part_of UBERON:0002067 ! dermis
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: part_of UBERON:0002067 ! dermis

[Term]
id: CL:0001007
name: interstitial dendritic cell
namespace: cell
def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10).
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001300 ! CD209 molecule
intersection_of: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4
intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a
intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001300 ! CD209 molecule
relationship: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4
relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a
relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1

[Term]
id: CL:0001008
name: Kit and Sca1-positive hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770]
comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).
synonym: "LSK stem cell" EXACT []
synonym: "Sca1-positive hematopoietic stem cell" EXACT []
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4
intersection_of: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4
relationship: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0001009
name: immature dermal dendritic cell
namespace: cell
def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001010
name: mature dermal dendritic cell
namespace: cell
def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0001009 ! immature dermal dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001011
name: immature interstitial dendritic cell
namespace: cell
def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell
intersection_of: CL:0001007 ! interstitial dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell

[Term]
id: CL:0001013
name: mature interstitial dendritic cell
namespace: cell
def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell
intersection_of: CL:0001007 ! interstitial dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0001011 ! immature interstitial dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001014
name: CD1a-positive Langerhans cell
namespace: cell
def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15.
synonym: "CD1a-LC" EXACT []
is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell
intersection_of: CL:0000453 ! Langerhans cell
intersection_of: has_plasma_membrane_part PR:000001447 ! cadherin-1
intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a
relationship: has_plasma_membrane_part PR:000001447 ! cadherin-1
relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a

[Term]
id: CL:0001015
name: CD8_alpha-low Langerhans cell
namespace: cell
def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9).
is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell
intersection_of: CL:0000453 ! Langerhans cell
intersection_of: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75
intersection_of: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75
relationship: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: CL:0001016
name: immature CD1a-positive Langerhans cell
namespace: cell
def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell
intersection_of: CL:0001014 ! CD1a-positive Langerhans cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001017
name: mature CD1a-positive Langerhans cell
namespace: cell
def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15.
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell
intersection_of: CL:0001014 ! CD1a-positive Langerhans cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001018
name: immature CD8_alpha-low Langerhans cell
namespace: cell
def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617).
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell
intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001020
name: mature CD8_alpha-low Langerhans cell
namespace: cell
def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585]
comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617).
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell
intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0001021
name: CD34-positive, CD38-positive common lymphoid progenitor
namespace: cell
def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770]
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin
disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001898 ! neprilysin

[Term]
id: CL:0001022
name: CD115-positive monocyte
namespace: cell
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).
is_a: CL:0000576 {is_inferred="true"} ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0000576 ! monocyte
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor

[Term]
id: CL:0001023
name: Kit-positive, CD34-positive common myeloid progenitor
namespace: cell
def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047]
comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617).
synonym: "CD117-positive common myeloid precursor" BROAD []
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: CL:0001059 {is_inferred="true"} ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
intersection_of: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
relationship: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1

[Term]
id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
namespace: cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721]
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).
synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871]
xref: CALOHA:TS-0448
xref: FMA:86475
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001786 ! prominin-1
intersection_of: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein
intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule
intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001786 ! prominin-1
relationship: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein
relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule
relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0001025
name: Kit-positive, Sca1-positive common lymphoid progenitor
namespace: cell
def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047]
comment: Markers are associated with mouse cells.
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: develops_from CL:0000936 ! early lymphoid progenitor
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0001026
name: CD34-positive, CD38-positive common myeloid progenitor
namespace: cell
def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251]
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor" NARROW []
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule
intersection_of: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001898 ! neprilysin
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule
relationship: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001898 ! neprilysin

[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
namespace: cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
synonym: "CD7-negative lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule
relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule

[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
namespace: cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
synonym: "CD7-positive lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001836 ! CD7 molecule
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001836 ! CD7 molecule
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA

[Term]
id: CL:0001029
name: common dendritic progenitor
namespace: cell
def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519]
comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).
synonym: "CDP" EXACT [PMID:21219184]
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT [PMID:21219184]
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76

[Term]
id: CL:0001030
name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor

[Term]
id: CL:0001031
name: cerebellar granule cell
namespace: cell
def: "Granule cell that is part of the cerebellum." [GOC:mah]
xref: BTO:0004278
is_a: CL:0000120 {is_inferred="true"} ! granule cell
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: CL:0001032
name: cortical granule cell
namespace: cell
def: "Granule cell that is part of the cerebral cortex." [GOC:mah]
is_a: CL:0000120 ! granule cell
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: CL:0001033
name: hippocampal granule cell
namespace: cell
def: "Granule cell that is part of the hippocampus." [GOC:mah]
is_a: CL:0001032 ! cortical granule cell
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn

[Term]
id: CL:0001034
name: cell in vitro
namespace: cell
def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." [ReO:mhb]
comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells.
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell
created_by: haendel
creation_date: 2012-01-12T09:58:38Z

[Term]
id: CL:0001035
name: bone cell
namespace: cell
def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add]
is_a: CL:0000548 {is_inferred="true"} ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element
created_by: adiehl
creation_date: 2011-11-16T04:28:16Z

[Term]
id: CL:0001039
name: terminally differentiated osteoblast
namespace: cl
def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator]
xref: VSAO:0000116
is_a: CL:0000062 ! osteoblast

[Term]
id: CL:0001040
name: non-terminally differentiated osteoblast
namespace: cl
def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator]
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
xref: VSAO:0000117
is_a: CL:0000062 ! osteoblast
is_a: CL:0001035 ! bone cell
relationship: part_of UBERON:0002481 ! bone tissue

[Term]
id: CL:0001041
name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [GOC:dsd, PMID:19609979]
comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction.
synonym: "CD8+CXCR3+ T cell" EXACT []
synonym: "CD8+CXCR3+ T lymphocyte" EXACT []
synonym: "CD8+CXCR3+ T(reg)" EXACT []
synonym: "CD8+CXCR3+ T-cell" EXACT []
synonym: "CD8+CXCR3+ T-lymphocyte " EXACT []
synonym: "CD8+CXCR3+ Treg" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT []
synonym: "CD8-positive, CXCR3-positive, Treg" EXACT []
is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell
intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
intersection_of: capable_of GO:0032613 ! interleukin-10 production
intersection_of: capable_of GO:0032689 ! negative regulation of interferon-gamma production
intersection_of: capable_of GO:0042130 ! negative regulation of T cell proliferation
intersection_of: has_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: capable_of GO:0032613 ! interleukin-10 production
relationship: capable_of GO:0032689 ! negative regulation of interferon-gamma production
relationship: capable_of GO:0042130 ! negative regulation of T cell proliferation
relationship: has_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0001042
name: T-helper 22 cell
namespace: cell
def: "CD4-positive, alpha-beta T cell that produces IL-22." [GOC:dsd, PMID:19578368, PMID:19578369]
comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13.
synonym: "helper T cell type 22" EXACT []
synonym: "T(H)-22 cell" EXACT []
synonym: "Th22 cell" EXACT []
synonym: "Th22 T cell" EXACT []
synonym: "Th22 T lymphocyte" EXACT []
synonym: "Th22 T-cell" EXACT []
synonym: "Th22 T-lymphocyte" EXACT []
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0032626 ! interleukin-22 production
relationship: capable_of GO:0032626 ! interleukin-22 production
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0001043
name: activated CD4-positive, alpha-beta T cell, human
namespace: cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CD4+ T cell" BROAD [PMID:22343568]
synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT []
is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell
intersection_of: CL:0000896 ! activated CD4-positive, alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0001044
name: effector CD4-positive, alpha-beta T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'.  The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy.
synonym: "effector CD4+ T cell" BROAD [PMID:22343568]
synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8

[Term]
id: CL:0001045
name: naive CCR4-positive regulatory T cell
namespace: cell
def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "naive CCR4+ Treg" EXACT [PMID:22343568]
synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT []
synonym: "naive CCR4-positive regulatory T-cell" EXACT []
synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
is_a: CL:0002677 ! naive regulatory T cell
intersection_of: CL:0002677 ! naive regulatory T cell
intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4
intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4
relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO

[Term]
id: CL:0001046
name: memory CCR4-positive regulatory T cell
namespace: cell
def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "memory CCR4+ Treg" EXACT [PMID:22343568]
synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT []
synonym: "memory CCR4-positive regulatory T-cell" EXACT []
synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
is_a: CL:0002678 ! memory regulatory T cell
intersection_of: CL:0002678 ! memory regulatory T cell
intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4
relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4

[Term]
id: CL:0001047
name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
namespace: cell
def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'.  The definition is valid for human; its applicability for mouse and other species is unknown.
synonym: "CCR+ Treg" EXACT [PMID:22343568]
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4
relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4

[Term]
id: CL:0001048
name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human
namespace: cell
def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CCR4+ Treg" EXACT [PMID:22343568]
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
intersection_of: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0001049
name: activated CD8-positive, alpha-beta T cell, human
namespace: cell
def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells.  The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II.
synonym: "activated CD8+ T cell" BROAD [PMID:22343568]
synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT []
is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell
intersection_of: CL:0000906 ! activated CD8-positive, alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0001050
name: effector CD8-positive, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'.  The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy.
synonym: "effector CD8+ T cell" BROAD [PMID:22343568]
synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000911 ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7

[Term]
id: CL:0001051
name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'.  Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells.
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Th1/Th17 CD4+ T cell" BROAD [PMID:22343568]
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0001052
name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'.  Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells.
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT []
synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [PMID:22343568]
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3
relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3

[Term]
id: CL:0001053
name: IgD-negative memory B cell
namespace: cell
def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'.  The majority of these cells are class-switched, though some are IgM-positive.
synonym: "IgD- memory B cell" EXACT [PMID:22343568]
is_a: CL:0000787 ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0001054
name: CD14-positive monocyte
namespace: cell
def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
synonym: "monocyte" NARROW [PMID:22343568]
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1

[Term]
id: CL:0001055
name: CD14-positive, CD16-low monocyte
namespace: cell
def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [GOC:add, PMID:20628149]
comment: Definition is valid for human intermediate monocytes.
synonym: "intermediate monocyte, human" EXACT []
is_a: CL:0002393 ! intermediate monocyte
is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte
intersection_of: CL:0002393 ! intermediate monocyte
intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule

[Term]
id: CL:0001056
name: dendritic cell, human
namespace: cell
def: "A dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells.
synonym: "dendritic cell" BROAD [PMID:22343568]
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0001057
name: myeloid dendritic cell, human
namespace: cell
def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells.
synonym: "myeloid dendritic cell" BROAD [PMID:22343568]
is_a: CL:0000782 ! myeloid dendritic cell
is_a: CL:0001056 ! dendritic cell, human
intersection_of: CL:0000782 ! myeloid dendritic cell
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA

[Term]
id: CL:0001058
name: plasmacytoid dendritic cell, human
namespace: cell
def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells.
synonym: "plasmacytoid dendritic cell" BROAD [PMID:22343568]
is_a: CL:0000784 ! plasmacytoid dendritic cell
is_a: CL:0001056 ! dendritic cell, human
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA
relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X

[Term]
id: CL:0001059
name: common myeloid progenitor, CD34-positive
namespace: cell
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566]
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
synonym: "CFU-GEMM" RELATED [ISBN:0878932437]
synonym: "CFU-S" RELATED [ISBN:0878932437]
synonym: "CMP" BROAD [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000049 ! common myeloid progenitor
intersection_of: capable_of GO:0002573 ! myeloid leukocyte differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: capable_of GO:0002573 ! myeloid leukocyte differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule

[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
namespace: cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770]
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: bearer_of PATO:0001401 ! oligopotent
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: bearer_of PATO:0001401 ! oligopotent
relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
created_by: tmeehan
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0001061
name: abnormal cell
namespace: cell
def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [GOC:add, GOC:cg, GOC:wdd]
comment: https://github.com/obophenotype/cell-ontology/issues/448
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913
is_a: CL:0000000 ! cell
is_a: GO:0005623 ! cell
intersection_of: GO:0005623 ! cell
intersection_of: bearer_of PATO:0000460 ! abnormal
relationship: bearer_of PATO:0000460 ! abnormal
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T18:53:32Z xsd:dateTime

[Term]
id: CL:0001062
name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated
namespace: cell
def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [GOC:add, GOC:dos, PMID:15032595, PMID:16237082]
comment: This cell type is seen human but not found in the mouse.
synonym: "TEMRA" EXACT [PMID:16237082]
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: develops_from CL:0000913 ! effector memory CD8-positive, alpha-beta T cell
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7

[Term]
id: CL:0001063
name: neoplastic cell
namespace: cell
def: "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." [GOC:add, GOC:cg, GOC:wdd]
comment: https://github.com/obophenotype/cell-ontology/issues/448
synonym: "tumor cell" RELATED []
synonym: "tumour cell" RELATED []
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922
is_a: CL:0001061 ! abnormal cell
intersection_of: CL:0001061 ! abnormal cell
intersection_of: bearer_of PATO:0002011 ! neoplastic
relationship: bearer_of PATO:0002011 ! neoplastic
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:16:26Z xsd:dateTime

[Term]
id: CL:0001064
name: malignant cell
namespace: cell
def: "A neoplastic cell that is capable of entering a surrounding tissue" [GOC:add, GOC:cg, GOC:wdd]
comment: https://github.com/obophenotype/cell-ontology/issues/448
synonym: "cancer cell" RELATED []
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917
is_a: CL:0001063 ! neoplastic cell
intersection_of: CL:0001063 ! neoplastic cell
intersection_of: bearer_of PATO:0002097 ! neoplastic, malignant
relationship: bearer_of PATO:0002097 ! neoplastic, malignant
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T19:39:12Z xsd:dateTime

[Term]
id: CL:0001065
name: innate lymphoid cell
namespace: cell
def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417]
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0045087 ! innate immune response
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:20:48Z xsd:dateTime

[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
namespace: cell
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464]
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G

[Term]
id: CL:0001067
name: group 1 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [GOC:add, GOC:dsd, PMID:23348417]
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
relationship: capable_of GO:0032609 ! interferon-gamma production
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:42:44Z xsd:dateTime

[Term]
id: CL:0001068
name: ILC1
namespace: cell
def: "A group 1 innate lymphoid cell that is non-cytotoxic." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417]
is_a: CL:0001067 ! group 1 innate lymphoid cell
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:54:12Z xsd:dateTime

[Term]
id: CL:0001069
name: group 2 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." [GOC:add, GOC:dsd, PMID:23292121, PMID:23562755]
synonym: "ILC2" EXACT []
synonym: "nuocyte" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: capable_of GO:0032634 ! interleukin-5 production
relationship: capable_of GO:0032634 ! interleukin-5 production
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T21:20:08Z xsd:dateTime

[Term]
id: CL:0001070
name: beige adipocyte
namespace: cell
def: "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." [GOC:add, GOC:cvs, GOC:ymb, PMID:22796012, PMID:25851693]
synonym: "beige brown adipocyte" EXACT []
synonym: "beige fat cell" EXACT []
synonym: "beige/brite adipocyte" EXACT []
synonym: "brite adipocyte" EXACT []
synonym: "brite cell" EXACT []
synonym: "brite fat cell" EXACT []
is_a: CL:0000136 ! fat cell
relationship: part_of UBERON:0001347 ! white adipose tissue

[Term]
id: CL:0001071
name: group 3 innate lymphoid cell
namespace: cell
def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417]
synonym: "ILC3" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331
property_value: http://purl.org/dc/elements/1.1/date 2017-01-31T20:21:26Z xsd:dateTime

[Term]
id: CL:0001658
name: visual pigment cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004230
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0002000
name: Kit-positive erythroid progenitor cell
namespace: cell
def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084]
comment: Markers found on mouse cells.
synonym: "c- Kit-positive erythroid progenitor cell" EXACT []
is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex
intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
relationship: has_plasma_membrane_part PR:000001345 ! endoglin
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex
relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
created_by: tmeehan
creation_date: 2010-04-26T10:14:16Z

[Term]
id: CL:0002001
name: CD34-positive, CD38-positive granulocyte monocyte progenitor
namespace: cell
def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770]
comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population.
is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
created_by: tmeehan
creation_date: 2010-01-13T03:19:22Z

[Term]
id: CL:0002002
name: Kit-positive granulocyte monocyte progenitor
namespace: cell
def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628]
comment: Markers are found on mouse cells.
is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
intersection_of: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
relationship: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
relationship: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-01-13T03:19:28Z

[Term]
id: CL:0002003
name: CD34-positive, GlyA-negative erythroid progenitor cell
namespace: cell
def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348]
comment: Cell markers associated with human cells.
xref: FMA:83517
is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A
created_by: tmeehan
creation_date: 2010-04-26T10:14:30Z

[Term]
id: CL:0002004
name: CD34-negative, GlyA-negative proerythroblast
namespace: cell
def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348]
comment: Cell surface markers are associated with human cells.
is_a: CL:0000547 {is_inferred="true"} ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A
created_by: tmeehan
creation_date: 2010-04-26T10:31:50Z

[Term]
id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
namespace: cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700]
comment: Markers are associated with human cell type.
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
created_by: tmeehan
creation_date: 2010-01-13T03:43:10Z

[Term]
id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
namespace: cell
def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770]
comment: Markers are associated with mouse cells.
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-01-13T03:43:12Z

[Term]
id: CL:0002007
name: Kit-low, CD34-positive eosinophil progenitor cell
namespace: cell
def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345]
comment: Markers are found on mouse cells.
is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell
intersection_of: CL:0000611 ! eosinophil progenitor cell
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-01-14T03:25:15Z

[Term]
id: CL:0002008
name: CD34-positive, CD38-positive eosinophil progenitor cell
namespace: cell
def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMCID:PMC2626675]
comment: Markers are associated with human cells.
is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell
intersection_of: CL:0000611 ! eosinophil progenitor cell
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain
created_by: tmeehan
creation_date: 2010-01-14T03:25:17Z

[Term]
id: CL:0002009
name: macrophage dendritic cell progenitor
namespace: cell
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628]
synonym: "MDP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
created_by: tmeehan
creation_date: 2010-01-19T02:51:58Z

[Term]
id: CL:0002010
name: pre-conventional dendritic cell
namespace: cell
def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm]
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: develops_from CL:0001029 ! common dendritic progenitor
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
created_by: tmeehan
creation_date: 2010-01-19T03:39:30Z

[Term]
id: CL:0002011
name: Kit-positive macrophage dendritic cell progenitor
namespace: cell
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628]
comment: Markers are associated with mouse cells.
synonym: "murine MDP" EXACT []
is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor
intersection_of: CL:0002009 ! macrophage dendritic cell progenitor
intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor
relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
created_by: tmeehan
creation_date: 2010-01-26T02:43:40Z

[Term]
id: CL:0002012
name: Kit-low proerythroblast
namespace: cell
def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Markers are associated with mouse cells.
is_a: CL:0000547 {is_inferred="true"} ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell
relationship: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-26T10:31:56Z

[Term]
id: CL:0002013
name: GlyA-positive basophillic erythroblast
namespace: cell
def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers are associated with human cells.
is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast
relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
created_by: tmeehan
creation_date: 2010-04-26T10:41:15Z

[Term]
id: CL:0002014
name: Kit-negative, Ly-76 high basophilic erythroblast
namespace: cell
def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Cell surface markers are associated with mouse cells.
is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002012 ! Kit-low proerythroblast
relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-26T10:41:22Z

[Term]
id: CL:0002015
name: Kit-negative, Ly-76 high polychromatophilic erythroblast
namespace: cell
def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
synonym: "late basophilic and polychromatophilic erythroblast" BROAD []
is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast
relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-26T10:53:11Z

[Term]
id: CL:0002016
name: CD71-low, GlyA-positive polychromatic erythroblast
namespace: cell
def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Cell surface markers are associated with human cells.
is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast
relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A
created_by: tmeehan
creation_date: 2010-04-26T10:53:16Z

[Term]
id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
namespace: cell
def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Cell surface markers associated with mouse cells.
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast
relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-26T11:04:15Z

[Term]
id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
namespace: cell
def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers associated with human cells.
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A
intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast
relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
created_by: tmeehan
creation_date: 2010-04-26T11:04:21Z

[Term]
id: CL:0002019
name: Ly-76 high reticulocyte
namespace: cell
def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294]
comment: Marker associated with mouse cells.
is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts
relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
created_by: tmeehan
creation_date: 2010-04-26T11:37:00Z

[Term]
id: CL:0002020
name: GlyA-positive reticulocytes
namespace: cell
def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers is associated with human cells.
is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast
relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A
created_by: tmeehan
creation_date: 2010-04-26T11:48:25Z

[Term]
id: CL:0002021
name: GlyA-positive erythrocyte
namespace: cell
def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094]
comment: Marker is associated with human cell types.
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A
relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes
relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A
created_by: tmeehan
creation_date: 2010-04-26T11:51:22Z

[Term]
id: CL:0002022
name: Ly-76 high positive erythrocyte
namespace: cell
def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Marker is associated with mouse cell types.
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte
relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76
created_by: tmeehan
creation_date: 2010-04-26T11:51:27Z

[Term]
id: CL:0002023
name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
namespace: cell
def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are associated with human cell type.
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
created_by: tmeehan
creation_date: 2010-04-26T02:39:09Z

[Term]
id: CL:0002024
name: Kit-positive megakaryocyte progenitor cell
namespace: cell
def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553]
comment: Markers are associated with mouse cells.
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule
intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
relationship: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule
relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-26T02:39:15Z

[Term]
id: CL:0002025
name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
namespace: cell
def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are commonly associated with human cells.
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
intersection_of: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
created_by: tmeehan
creation_date: 2010-04-26T03:52:47Z

[Term]
id: CL:0002026
name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell
namespace: cell
def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are commonly associated with human cells.
is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain
relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
created_by: tmeehan
creation_date: 2010-04-26T03:59:22Z

[Term]
id: CL:0002027
name: CD9-positive, CD41-positive megakaryocyte cell
namespace: cell
def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm]
comment: Markers are commonly associated with mouse cells.
is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule
intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell
relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule
relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
created_by: tmeehan
creation_date: 2010-04-27T10:39:07Z

[Term]
id: CL:0002028
name: basophil mast progenitor cell
namespace: cell
def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421]
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
synonym: "BMCP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0030221 ! basophil differentiation
intersection_of: capable_of GO:0060374 ! mast cell differentiation
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1
relationship: capable_of GO:0030221 ! basophil differentiation
relationship: capable_of GO:0060374 ! mast cell differentiation
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1
created_by: tmeehan
creation_date: 2010-04-27T12:46:33Z

[Term]
id: CL:0002029
name: Fc-epsilon RIalpha-low mast cell progenitor
namespace: cell
def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMCID:PMC1312421]
is_a: CL:0000831 {is_inferred="true"} ! mast cell progenitor
intersection_of: CL:0000831 ! mast cell progenitor
intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000009143 ! integrin beta-7
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000009143 ! integrin beta-7
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-27T01:22:19Z

[Term]
id: CL:0002030
name: Fc-epsilon RIalpha-high basophil progenitor cell
namespace: cell
def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMCID:PMC1312421]
comment: Markers are associated with mouse cells.
is_a: CL:0000613 {is_inferred="true"} ! basophil progenitor cell
intersection_of: CL:0000613 ! basophil progenitor cell
intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell
relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-27T01:22:32Z

[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
namespace: cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001400 ! unipotent
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: bearer_of PATO:0001400 ! unipotent
relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell
created_by: tmeehan
creation_date: 2010-01-06T03:43:20Z

[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
namespace: cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell.  For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001401 ! oligopotent
relationship: bearer_of PATO:0001401 ! oligopotent
relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell
created_by: tmeehan
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0002033
name: short term hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770]
comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low.
synonym: "ST stem cell" EXACT []
synonym: "ST-HSC" EXACT []
is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: develops_from CL:0002034 ! long term hematopoietic stem cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
created_by: tmeehan
creation_date: 2010-01-08T09:19:25Z

[Term]
id: CL:0002034
name: long term hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345]
comment: Markers are associated with mouse cells.
synonym: "LT stem cell" EXACT []
synonym: "LT-HSC" EXACT []
is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein
intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein
relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
created_by: tmeehan
creation_date: 2010-01-08T09:19:28Z

[Term]
id: CL:0002035
name: Slamf1-negative multipotent progenitor cell
namespace: cell
def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells.
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3
created_by: tmeehan
creation_date: 2010-01-08T11:16:33Z

[Term]
id: CL:0002036
name: Slamf1-positive multipotent progenitor cell
namespace: cell
def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells.
synonym: "KSL cell" EXACT []
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: develops_from CL:0002033 ! short term hematopoietic stem cell
relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-01-08T11:16:35Z

[Term]
id: CL:0002037
name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell
namespace: cell
def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545]
synonym: "memory alpha beta IEL" EXACT [PMID:16048545]
is_a: CL:0000793 {is_inferred="true"} ! CD4-positive, alpha-beta intraepithelial T cell
intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell
intersection_of: has_plasma_membrane_part PR:000001083 ! CD2 molecule
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: has_plasma_membrane_part PR:000001083 ! CD2 molecule
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
created_by: tmeehan
creation_date: 2009-10-20T02:20:43Z

[Term]
id: CL:0002038
name: T follicular helper cell
namespace: cell
def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829]
synonym: "follicular B helper T cell" RELATED [PMID:22043829]
synonym: "follicular helper T cell" RELATED [PMID:22649468]
synonym: "follicular helper T-cell" RELATED [PMID:22508770]
synonym: "follicular T cell" RELATED [PMID:20107805, PMID:21914188]
synonym: "follicular T-cell" RELATED []
synonym: "follicular T-helper cell" RELATED [PMID:22552227]
synonym: "T(FH)" EXACT [PMID:20207847]
synonym: "Tfh" EXACT [PMID:20107805, PMID:20383172]
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0045830 ! positive regulation of isotype switching
intersection_of: capable_of GO:0051024 ! positive regulation of immunoglobulin secretion
intersection_of: has_part PR:000003450 ! B-cell lymphoma 6 protein
intersection_of: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5
intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator
intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1
intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
relationship: capable_of GO:0045830 ! positive regulation of isotype switching
relationship: capable_of GO:0051024 ! positive regulation of immunoglobulin secretion
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell
relationship: has_part PR:000003450 ! B-cell lymphoma 6 protein
relationship: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5
relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator
relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1
relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7
created_by: tmeehan
creation_date: 2009-10-29T04:01:27Z

[Term]
id: CL:0002039
name: immature NK T cell stage I
namespace: cell
def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542]
is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule
intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte
relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule
relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
created_by: tmeehan
creation_date: 2009-10-29T04:09:16Z

[Term]
id: CL:0002040
name: immature NK T cell stage II
namespace: cell
def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542]
comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org.
synonym: "NKT.44-NK1.1-.Th" EXACT []
is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: develops_from CL:0002039 ! immature NK T cell stage I
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
created_by: tmeehan
creation_date: 2009-10-29T04:13:43Z

[Term]
id: CL:0002041
name: immature NK T cell stage III
namespace: cell
def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542]
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: develops_from CL:0002040 ! immature NK T cell stage II
relationship: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
created_by: tmeehan
creation_date: 2009-10-29T04:14:48Z

[Term]
id: CL:0002042
name: immature NK T cell stage IV
namespace: cell
def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542]
synonym: "NKT.44+.NK1.1-.Th" BROAD []
is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell
intersection_of: CL:0000914 ! immature NK T cell
intersection_of: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: develops_from CL:0002041 ! immature NK T cell stage III
relationship: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
created_by: tmeehan
creation_date: 2009-10-29T04:17:38Z

[Term]
id: CL:0002043
name: CD34-positive, CD38-negative multipotent progenitor cell
namespace: cell
def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770]
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein
created_by: tmeehan
creation_date: 2010-01-12T11:14:15Z

[Term]
id: CL:0002044
name: Kit-positive, integrin beta7-high basophil mast progenitor cell
namespace: cell
def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm]
comment: Markers are associated with mouse cells.
is_a: CL:0002028 {is_inferred="true"} ! basophil mast progenitor cell
intersection_of: CL:0002028 ! basophil mast progenitor cell
intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7
intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7
relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
created_by: tmeehan
creation_date: 2010-04-27T01:22:38Z

[Term]
id: CL:0002045
name: Fraction A pre-pro B cell
namespace: cell
def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343]
comment: Markers associated with mouse cells.
synonym: "fraction A" EXACT []
synonym: "pre pro B cell" RELATED []
is_a: CL:0000826 {is_inferred="true"} ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
created_by: tmeehan
creation_date: 2010-04-28T10:50:07Z

[Term]
id: CL:0002046
name: early pro-B cell
namespace: cell
def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934]
comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
is_a: CL:0000826 {is_inferred="true"} ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin
intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin
relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
created_by: tmeehan
creation_date: 2010-04-28T11:19:11Z

[Term]
id: CL:0002047
name: Fraction B precursor B cell
namespace: cell
def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934]
comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive.
synonym: "Fr. B" EXACT []
synonym: "Fraction B" EXACT []
is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell
intersection_of: CL:0002400 ! Fraction B/C precursor B cell
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
created_by: tmeehan
creation_date: 2010-04-28T11:56:21Z

[Term]
id: CL:0002048
name: late pro-B cell
namespace: cell
def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934]
comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: develops_from CL:0002046 ! early pro-B cell
relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
created_by: tmeehan
creation_date: 2010-04-28T12:06:06Z

[Term]
id: CL:0002049
name: Fraction C precursor B cell
namespace: cell
def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343]
synonym: "Fraction C" RELATED []
is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell
intersection_of: CL:0002400 ! Fraction B/C precursor B cell
intersection_of: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
intersection_of: has_part PR:000001858 ! immunoglobulin iota chain
intersection_of: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
intersection_of: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: develops_from CL:0002047 ! Fraction B precursor B cell
relationship: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
relationship: has_part PR:000001858 ! immunoglobulin iota chain
relationship: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
relationship: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2
created_by: tmeehan
creation_date: 2010-04-28T02:04:01Z

[Term]
id: CL:0002050
name: Fraction C' precursor B cell
namespace: cell
def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343]
synonym: "Fr. C'" EXACT []
synonym: "Fraction C-prime" EXACT []
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
relationship: develops_from CL:0002049 ! Fraction C precursor B cell
relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
created_by: tmeehan
creation_date: 2010-04-28T02:13:46Z

[Term]
id: CL:0002051
name: CD38-high pre-BCR positive cell
namespace: cell
def: "A pre-BCR positive T cell that is CD38-high." [GOC:tfm, PMID:18432934]
comment: Markers are associated with human cells.
synonym: "large pre-B cell type I" RELATED []
is_a: CL:0000952 {is_inferred="true"} ! preBCR-positive large pre-B-II cell
intersection_of: CL:0000952 ! preBCR-positive large pre-B-II cell
intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
relationship: develops_from CL:0002048 ! late pro-B cell
relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
created_by: tmeehan
creation_date: 2010-04-28T02:27:47Z

[Term]
id: CL:0002052
name: Fraction D precursor B cell
namespace: cell
def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934]
comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative.
synonym: "Fr. D" EXACT []
synonym: "Fraction D pre-B cell" EXACT [GOC:tfm]
is_a: CL:0002400 ! Fraction B/C precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin
intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
relationship: develops_from CL:0002050 ! Fraction C' precursor B cell
relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin
relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination
relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase
relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex
created_by: tmeehan
creation_date: 2010-04-28T02:55:16Z

[Term]
id: CL:0002053
name: CD22-positive, CD38-low small pre-B cell
namespace: cell
def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934]
comment: Markers are associated with human cell. RAG expression maybe diminishing.
synonym: "small pre-B cell" EXACT []
is_a: CL:0000954 {is_inferred="true"} ! small pre-B-II cell
intersection_of: CL:0000954 ! small pre-B-II cell
intersection_of: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell
relationship: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22
created_by: tmeehan
creation_date: 2010-04-28T03:04:48Z

[Term]
id: CL:0002054
name: Fraction E immature B cell
namespace: cell
def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934]
comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative.
is_a: CL:0000816 {is_inferred="true"} ! immature B cell
intersection_of: CL:0000816 ! immature B cell
intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: develops_from CL:0002052 ! Fraction D precursor B cell
relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
created_by: tmeehan
creation_date: 2010-04-28T03:13:47Z

[Term]
id: CL:0002055
name: CD38-negative immature B cell
namespace: cell
def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934]
comment: Markers are associated with human cell type.
is_a: CL:0000816 {is_inferred="true"} ! immature B cell
intersection_of: CL:0000816 ! immature B cell
intersection_of: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22
intersection_of: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2
intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell
relationship: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22
relationship: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2
relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
created_by: tmeehan
creation_date: 2010-04-28T03:19:14Z

[Term]
id: CL:0002056
name: Fraction F mature B cell
namespace: cell
def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343]
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: develops_from CL:0002054 ! Fraction E immature B cell
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin
relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor
relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
created_by: tmeehan
creation_date: 2010-04-30T03:01:48Z

[Term]
id: CL:0002057
name: CD14-positive, CD16-negative classical monocyte
namespace: cell
def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [GOC:add, GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes.
synonym: "CD16- monocyte" EXACT [PMID:22343568]
synonym: "CD16-negative monocyte" EXACT []
is_a: CL:0000860 {is_inferred="true"} ! classical monocyte
is_a: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:0000860 ! classical monocyte
intersection_of: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I
intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I
relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
created_by: tmeehan
creation_date: 2010-06-05T08:25:41Z

[Term]
id: CL:0002058
name: Gr1-low non-classical monocyte
namespace: cell
def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901]
comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative.
is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte
is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte
intersection_of: CL:0000875 ! non-classical monocyte
intersection_of: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2
intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte
relationship: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2
relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
created_by: tmeehan
creation_date: 2010-06-05T08:25:44Z

[Term]
id: CL:0002059
name: CD8alpha-positive thymic conventional dendritic cell
namespace: cell
def: "A conventional thymic dendritic cell that is CD8alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629]
synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT []
synonym: "DC.8+.Th" EXACT []
is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2010-06-07T02:48:36Z

[Term]
id: CL:0002060
name: melanophage
namespace: cell
def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821]
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: has_part CHEBI:25179 ! melanin
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: has_part CHEBI:25179 ! melanin
relationship: part_of UBERON:0002097 ! skin of body
created_by: tmeehan
creation_date: 2010-06-22T10:46:12Z

[Term]
id: CL:0002061
name: T-helper 9 cell
namespace: cell
def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671]
synonym: "T helper cells type 9" EXACT []
synonym: "T(H)-9 cell" EXACT []
synonym: "Th9" EXACT [PMID:18931678]
is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell
intersection_of: CL:0000492 ! CD4-positive helper T cell
intersection_of: capable_of GO:0002215 ! defense response to nematode
intersection_of: capable_of GO:0032638 ! interleukin-9 production
intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B
relationship: capable_of GO:0002215 ! defense response to nematode
relationship: capable_of GO:0032638 ! interleukin-9 production
relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B
created_by: tmeehan
creation_date: 2010-06-22T11:18:44Z

[Term]
id: CL:0002062
name: type I pneumocyte
namespace: cell
def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144]
synonym: "AT1" EXACT []
synonym: "ATI" EXACT []
synonym: "lung type 1 cells" EXACT []
synonym: "membranous pneumocytes" EXACT []
synonym: "pulmonary alveolar type I cell" EXACT []
synonym: "small alveolar cells" EXACT []
synonym: "squamous alveolar cell" EXACT []
synonym: "squamous alveolar lining cell" EXACT []
synonym: "type 1 alveolar epithelial cells" EXACT []
synonym: "type 1 pneumocyte" EXACT []
synonym: "type I alveolar cells" EXACT []
synonym: "type I alveolar epithelial cells" EXACT []
xref: BTO:0000780
xref: FMA:62500
is_a: CL:0000322 ! pneumocyte
intersection_of: CL:0000322 ! pneumocyte
intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange
relationship: capable_of GO:0007585 ! respiratory gaseous exchange
created_by: tmeehan
creation_date: 2010-06-23T04:37:54Z

[Term]
id: CL:0002063
name: type II pneumocyte
namespace: cell
def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:8540632]
synonym: "AT2" EXACT []
synonym: "ATII" EXACT []
synonym: "cuboidal type II cell" EXACT []
synonym: "granular pneumocyte" EXACT []
synonym: "great alveolar cell" EXACT []
synonym: "lung type 2 cell" EXACT []
synonym: "lung type II cell" RELATED []
synonym: "TII" EXACT []
synonym: "type 2 alveolar epithelial cell" EXACT []
synonym: "type 2 alveolocyte" EXACT []
synonym: "type 2 pneumocyte" EXACT []
synonym: "type II alveolar cell" EXACT []
synonym: "type II alveolar epithelial cell" EXACT []
synonym: "type II alveolocyte" EXACT []
xref: BTO:0000538
xref: FMA:62501
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000322 ! pneumocyte
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000322 ! pneumocyte
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: capable_of GO:0043129 ! surfactant homeostasis
relationship: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0043129 ! surfactant homeostasis
created_by: tmeehan
creation_date: 2010-06-24T12:04:13Z

[Term]
id: CL:0002064
name: pancreatic acinar cell
namespace: cell
def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539]
synonym: "acinar cell of pancreas" EXACT []
xref: BTO:0000028
xref: CALOHA:TS-0737
xref: FMA:63032
is_a: CL:0000622 {is_inferred="true"} ! acinar cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: has_part GO:0042589 ! zymogen granule membrane
relationship: part_of UBERON:0001263 ! pancreatic acinus
created_by: tmeehan
creation_date: 2010-06-24T03:16:29Z

[Term]
id: CL:0002066
name: Feyrter cell
namespace: cell
def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651]
synonym: "bronchiolar Kulchitsky cell" EXACT []
synonym: "Kultschitzky cell of bronchiole" EXACT []
synonym: "P cell" BROAD []
synonym: "respiratory enterochromaffin cell " EXACT []
xref: FMA:14118
is_a: CL:0000165 ! neuroendocrine cell
created_by: tmeehan
creation_date: 2010-06-28T08:24:30Z

[Term]
id: CL:0002067
name: type A enterocrine cell
namespace: cell
def: "An enterocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911]
xref: FMA:62939
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000170 ! glucagon secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion
created_by: tmeehan
creation_date: 2010-09-10T10:48:54Z

[Term]
id: CL:0002068
name: Purkinje myocyte
namespace: cell
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742]
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
xref: BTO:0001032
xref: FMA:14146
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-28T08:36:15Z

[Term]
id: CL:0002069
name: type II vestibular sensory cell
namespace: cell
def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651]
synonym: "type 2 vestibular hair cell" EXACT []
synonym: "type 2 vestibular sensory cell" EXACT []
synonym: "type II hair cell" EXACT []
xref: FMA:67909
is_a: CL:0000609 ! vestibular hair cell
created_by: tmeehan
creation_date: 2010-06-29T09:58:13Z

[Term]
id: CL:0002070
name: type I vestibular sensory cell
namespace: cell
def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651]
synonym: "type 1 vestibular hair cell" EXACT []
synonym: "type 1 vestibular sensory cell" EXACT []
synonym: "type I hair cell" EXACT []
xref: FMA:62352
is_a: CL:0000609 ! vestibular hair cell
created_by: tmeehan
creation_date: 2010-06-29T09:58:19Z

[Term]
id: CL:0002071
name: enterocyte of epithelium of large intestine
namespace: cell
def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [GOC:tfm, ISBN:0517223651]
synonym: "columnar cell" BROAD []
synonym: "columnar cell of the colon" EXACT []
synonym: "vacuolar absorptive cell" EXACT []
xref: BTO:0002484
xref: FMA:63638
xref: FMA:66771
is_a: CL:0000584 ! enterocyte
is_a: CL:0002253 {is_inferred="true"} ! epithelial cell of large intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0001278 ! epithelium of large intestine
created_by: tmeehan
creation_date: 2010-06-29T11:07:25Z

[Term]
id: CL:0002072
name: nodal myocyte
namespace: cell
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm]
synonym: "cardiac pacemaker cell" EXACT [GOC:pr]
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
xref: BTO:0004190
xref: FMA:67101
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T11:41:37Z

[Term]
id: CL:0002073
name: transitional myocyte
namespace: cell
def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm]
xref: FMA:67142
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T02:39:32Z

[Term]
id: CL:0002074
name: myocardial endocrine cell
namespace: cell
def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm]
xref: FMA:67111
is_a: CL:0000163 ! endocrine cell
is_a: CL:0002086 ! specialized cardiac myocyte
created_by: tmeehan
creation_date: 2010-06-29T11:50:47Z

[Term]
id: CL:0002075
name: brush cell of trachebronchial tree
namespace: cell
def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [GOC:tfm, ISBN:0517223651, PMID:15817800]
synonym: "pulmonary brush cell" RELATED []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002204 ! brush cell
intersection_of: CL:0002204 ! brush cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: part_of UBERON:0007196 ! tracheobronchial tree
created_by: tmeehan
creation_date: 2010-06-29T03:22:46Z

[Term]
id: CL:0002076
name: endo-epithelial cell
namespace: cell
def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm]
xref: FMA:69075
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000223 ! endodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:38:14Z

[Term]
id: CL:0002077
name: ecto-epithelial cell
namespace: cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
xref: FMA:69074
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000221 ! ectodermal cell
relationship: develops_from CL:0000221 ! ectodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:38:22Z

[Term]
id: CL:0002078
name: meso-epithelial cell
namespace: cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000222 ! mesodermal cell
created_by: tmeehan
creation_date: 2010-06-29T03:49:14Z

[Term]
id: CL:0002079
name: pancreatic ductal cell
namespace: cell
def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223]
xref: FMA:63099
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: part_of UBERON:0001064 ! ventral pancreatic duct
created_by: tmeehan
creation_date: 2010-06-30T08:49:43Z

[Term]
id: CL:0002080
name: pancreatic centro-acinar cell
namespace: cell
def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160]
synonym: "centroacinar cell of Langerhans" EXACT []
synonym: "pancreatic centroacinar cell" EXACT []
xref: FMA:62455
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: part_of UBERON:0001263 ! pancreatic acinus
created_by: tmeehan
creation_date: 2010-06-30T08:49:52Z

[Term]
id: CL:0002081
name: type II cell of carotid body
namespace: cell
def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227]
synonym: "sheath cell of carotid body" EXACT []
xref: FMA:84187
is_a: CL:0000703 ! sustentacular cell
is_a: CL:0002256 ! supporting cell of carotid body
created_by: tmeehan
creation_date: 2010-06-30T04:23:42Z

[Term]
id: CL:0002082
name: type II cell of adrenal medulla
namespace: cell
def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm]
synonym: "adremergic chromaffin cell" EXACT []
synonym: "adrenal secreting cell of the adrenal medulla" EXACT []
synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT []
xref: FMA:69322
is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell
is_a: CL:0000454 ! epinephrine secreting cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048242 ! epinephrine secretion
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: capable_of GO:0048242 ! epinephrine secretion
relationship: part_of UBERON:0001236 ! adrenal medulla
created_by: tmeehan
creation_date: 2010-07-14T09:41:42Z

[Term]
id: CL:0002083
name: type I cell of adrenal medulla
namespace: cell
def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X]
synonym: "noradrenergic chromaffin cell" EXACT []
xref: FMA:69321
is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell
is_a: CL:0000459 ! noradrenergic cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: capable_of GO:0048243 ! norepinephrine secretion
relationship: part_of UBERON:0001236 ! adrenal medulla
created_by: tmeehan
creation_date: 2010-07-14T10:12:24Z

[Term]
id: CL:0002084
name: Boettcher cell
namespace: cell
def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell]
synonym: "Boettcher's cell" EXACT []
synonym: "Bottcher cell" EXACT []
synonym: "Bottcher's cell" EXACT []
is_a: CL:0002315 ! supporting cell of cochlea
created_by: tmeehan
creation_date: 2010-07-14T03:22:02Z

[Term]
id: CL:0002085
name: tanycyte
namespace: cell
alt_id: CL:0000643
def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte]
synonym: "stretch cell" EXACT []
xref: BTO:0001953
xref: FMA:54560
is_a: CL:0000683 ! ependymoglial cell
created_by: tmeehan
creation_date: 2010-07-15T11:21:11Z

[Term]
id: CL:0002086
name: specialized cardiac myocyte
namespace: cell
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm]
xref: FMA:67968
is_a: CL:0000746 ! cardiac muscle cell
created_by: tmeehan
creation_date: 2010-07-21T01:33:38Z

[Term]
id: CL:0002087
name: nongranular leukocyte
namespace: cell
def: "A leukocyte that lacks granules." [GOC:tfm]
synonym: "agranular leukocyte" EXACT []
xref: FMA:62855
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: lacks_part GO:0030141 ! secretory granule
relationship: lacks_part GO:0030141 ! secretory granule
created_by: tmeehan
creation_date: 2010-07-22T11:30:33Z

[Term]
id: CL:0002088
name: interstitial cell of Cajal
namespace: cell
def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112]
comment: Some argue this cell type is of mesenchymal origin.
synonym: "ICC" EXACT []
synonym: "intestinal pacemaker cell" EXACT [GOC:pr]
xref: BTO:0003914
xref: FMA:86573
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction
relationship: capable_of GO:0043134 ! regulation of hindgut contraction
created_by: tmeehan
creation_date: 2010-07-22T03:26:00Z

[Term]
id: CL:0002089
name: group 2 innate lymphoid cell, mouse
namespace: cell
def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:add, GOC:tfm, PMID:20200518]
synonym: "nuocyte" BROAD []
is_a: CL:0001069 {is_inferred="true"} ! group 2 innate lymphoid cell
intersection_of: CL:0001069 ! group 2 innate lymphoid cell
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
intersection_of: capable_of GO:0032616 ! interleukin-13 production
intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B
intersection_of: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2
intersection_of: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5
intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response
relationship: capable_of GO:0032616 ! interleukin-13 production
relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B
relationship: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2
relationship: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1
relationship: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5
relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha
created_by: tmeehan
creation_date: 2010-08-12T02:22:19Z

[Term]
id: CL:0002090
name: polar body
namespace: cell
def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X]
xref: EHDAA2:0004716
xref: FMA:85543
xref: WBbt:0008429
xref: XAO:0000262
is_a: CL:0000021 ! female germ cell
created_by: tmeehan
creation_date: 2010-08-23T09:49:53Z

[Term]
id: CL:0002091
name: primary polar body
namespace: cell
def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X]
synonym: "first polar body" EXACT [EHDAA2:0000541]
synonym: "polocytus primarius" EXACT [FMA:18650]
xref: EHDAA2:0000541
xref: EMAPA:16032
xref: FMA:18650
xref: VHOG:0000464
is_a: CL:0002090 ! polar body
created_by: tmeehan
creation_date: 2010-08-23T09:49:58Z

[Term]
id: CL:0002092
name: bone marrow cell
namespace: cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256]
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
xref: BTO:0004850
xref: FMA:83621
is_a: CL:0001035 {is_inferred="true"} ! bone cell
intersection_of: CL:0001035 ! bone cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: tmeehan
creation_date: 2010-07-22T04:48:15Z

[Term]
id: CL:0002093
name: secondary polar body
namespace: cell
def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X]
synonym: "polocytus secundarius" EXACT [FMA:18651]
synonym: "second polar body" EXACT [EHDAA2:0001820]
xref: EHDAA2:0001820
xref: EMAPA:16034
xref: EMAPA:16045
xref: FMA:18651
is_a: CL:0002090 ! polar body
created_by: tmeehan
creation_date: 2010-08-23T09:50:01Z

[Term]
id: CL:0002094
name: interstitial cell of ovary
namespace: cell
def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm]
xref: FMA:18709
is_a: CL:0002132 ! stromal cell of ovary
created_by: tmeehan
creation_date: 2010-08-23T11:11:34Z

[Term]
id: CL:0002095
name: hilus cell of ovary
namespace: cell
def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X]
synonym: "hilar cell of ovary" EXACT []
xref: FMA:18710
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002132 ! stromal cell of ovary
created_by: tmeehan
creation_date: 2010-08-23T11:18:18Z

[Term]
id: CL:0002096
name: internodal tract myocyte
namespace: cell
def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300]
xref: FMA:223275
is_a: CL:0002086 ! specialized cardiac myocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract
created_by: tmeehan
creation_date: 2010-08-23T11:24:11Z

[Term]
id: CL:0002097
name: cortical cell of adrenal gland
namespace: cell
def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm]
synonym: "adrenal cortex cell" EXACT []
synonym: "adrenocortical cell" EXACT []
xref: FMA:69545
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: part_of UBERON:0001235 ! adrenal cortex
created_by: tmeehan
creation_date: 2010-08-24T01:37:44Z

[Term]
id: CL:0002098
name: regular cardiac myocyte
namespace: cell
def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [GOC:tfm]
synonym: "regular cardiac muscle cell" EXACT []
synonym: "regular cardiac muscle fiber" EXACT []
xref: FMA:67967
is_a: CL:0000746 ! cardiac muscle cell
created_by: tmeehan
creation_date: 2010-08-23T11:33:10Z

[Term]
id: CL:0002099
name: type I cell of adrenal cortex
namespace: cell
alt_id: CL:1000423
def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651]
synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT []
xref: FMA:69273
is_a: CL:0000456 ! mineralocorticoid secreting cell
is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland
intersection_of: CL:0002097 ! cortical cell of adrenal gland
intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
created_by: tmeehan
creation_date: 2010-08-24T01:42:02Z

[Term]
id: CL:0002100
name: regular interventricular cardiac myocyte
namespace: cell
def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm]
xref: FMA:228792
is_a: CL:0002098 ! regular cardiac myocyte
created_by: tmeehan
creation_date: 2010-08-23T11:40:52Z

[Term]
id: CL:0002101
name: CD38-positive naive B cell
namespace: cell
def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ naive B cell" EXACT []
synonym: "CD38+ naive B lymphocyte" EXACT []
synonym: "CD38+ naive B-cell" EXACT []
synonym: "CD38+ naive B-lymphocyte" EXACT []
synonym: "CD38-positive naive B lymphocyte" EXACT []
synonym: "CD38-positive naive B-cell" EXACT []
synonym: "CD38-positive naive B-lymphocyte" EXACT []
is_a: CL:0000788 {is_inferred="true"} ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002102
name: CD38-negative naive B cell
namespace: cell
def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38- naive B cell" EXACT []
synonym: "CD38- naive B lymphocyte" EXACT []
synonym: "CD38- naive B-cell" EXACT []
synonym: "CD38- naive B-lymphocyte" EXACT []
synonym: "CD38-negative naive B lymphocyte" EXACT []
synonym: "CD38-negative naive B-cell" EXACT []
synonym: "CD38-negative naive B-lymphocyte" EXACT []
is_a: CL:0000788 {is_inferred="true"} ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002103
name: IgG-positive double negative memory B cell
namespace: cell
def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "IgG+ dn memory B cell" EXACT []
synonym: "IgG+ dn memory B lymphocyte" EXACT []
synonym: "IgG+ dn memory B-cell" EXACT []
synonym: "IgG+ dn memory B-lymphocyte" EXACT []
synonym: "IgG+ double negative memory B cell" EXACT []
synonym: "IgG+ double negative memory B lymphocyte" EXACT []
synonym: "IgG+ double negative memory B-cell" EXACT []
synonym: "IgG+ double negative memory B-lymphocyte" EXACT []
synonym: "IgG-positive dn memory B cell" EXACT []
synonym: "IgG-positive dn memory B lymphocyte" EXACT []
synonym: "IgG-positive dn memory B-cell" EXACT []
synonym: "IgG-positive dn memory B-lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B-cell" EXACT []
synonym: "IgG-positive double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex

[Term]
id: CL:0002104
name: IgG-negative double negative memory B cell
namespace: cell
def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "IgG- dn memory B cell" EXACT []
synonym: "IgG- dn memory B lymphocyte" EXACT []
synonym: "IgG- dn memory B-cell" EXACT []
synonym: "IgG- dn memory B-lymphocyte" EXACT []
synonym: "IgG- double negative memory B cell" EXACT []
synonym: "IgG- double negative memory B lymphocyte" EXACT []
synonym: "IgG- double negative memory B-cell" EXACT []
synonym: "IgG- double negative memory B-lymphocyte" EXACT []
synonym: "IgG-negative dn memory B cell" EXACT []
synonym: "IgG-negative dn memory B lymphocyte" EXACT []
synonym: "IgG-negative dn memory B-cell" EXACT []
synonym: "IgG-negative dn memory B-lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B-cell" EXACT []
synonym: "IgG-negative double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex

[Term]
id: CL:0002105
name: CD38-positive IgG memory B cell
namespace: cell
def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ IgG memory B cell" EXACT []
synonym: "CD38+ IgG memory B lymphocyte" EXACT []
synonym: "CD38+ IgG memory B-cell" EXACT []
synonym: "CD38+ IgG memory B-lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B-cell" EXACT []
synonym: "CD38-positive IgG memory B-lymphocyte" EXACT []
is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002106
name: IgD-positive CD38-positive IgG memory B cell
namespace: cell
def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0002107
name: IgD-negative CD38-positive IgG memory B cell
namespace: cell
def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0001053 ! IgD-negative memory B cell
is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex

[Term]
id: CL:0002108
name: CD38-negative IgG memory B cell
namespace: cell
def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002109
name: B220-positive CD38-positive naive B cell
namespace: cell
def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "B220+CD38+ naive B cell" EXACT []
synonym: "B220+CD38+ naive B lymphocyte" EXACT []
synonym: "B220+CD38+ naive B-cell" EXACT []
synonym: "B220+CD38+ naive B-lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B-cell" EXACT []
synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT []
synonym: "CD38+B220+ naive B cell" EXACT []
synonym: "CD38+B220+ naive B lymphocyte" EXACT []
synonym: "CD38+B220+ naive B-cell" EXACT []
synonym: "CD38+B220+ naive B-lymphocyte" EXACT []
is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002110
name: B220-low CD38-positive naive B cell
namespace: cell
def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002109 ! B220-positive CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002111
name: CD38-negative unswitched memory B cell
namespace: cell
def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38- unswitched memory B cell" EXACT []
synonym: "CD38- unswitched memory B lymphocyte" EXACT []
synonym: "CD38- unswitched memory B-cell" EXACT []
synonym: "CD38- unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B-cell" EXACT []
synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002112
name: B220-positive CD38-negative unswitched memory B cell
namespace: cell
def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002113
name: B220-low CD38-negative unswitched memory B cell
namespace: cell
def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002114
name: CD38-positive unswitched memory B cell
namespace: cell
def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ unswitched memory B cell" EXACT []
synonym: "CD38+ unswitched memory B lymphocyte" EXACT []
synonym: "CD38+ unswitched memory B-cell" EXACT []
synonym: "CD38+ unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B-cell" EXACT []
synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002115
name: B220-positive CD38-positive unswitched memory B cell
namespace: cell
def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002116
name: B220-low CD38-positive unswitched memory B cell
namespace: cell
def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002117
name: IgG-negative class switched memory B cell
namespace: cell
def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "IgG- class switched memory B cell" EXACT []
synonym: "IgG- class switched memory B lymphocyte" EXACT []
synonym: "IgG- class switched memory B-cell" EXACT []
synonym: "IgG- class switched memory B-lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B-cell" EXACT []
synonym: "IgG-negative class switched memory B-lymphocyte" EXACT []
is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex
relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex

[Term]
id: CL:0002118
name: CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002119
name: CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1
relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1

[Term]
id: CL:0002120
name: CD24-positive CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24

[Term]
id: CL:0002121
name: CD24-negative CD38-negative IgG-negative class switched memory B cell
namespace: cell
def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24

[Term]
id: CL:0002122
name: B220-positive CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002123
name: B220-low CD38-positive IgG-negative class switched memory B cell
namespace: cell
def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R

[Term]
id: CL:0002124
name: CD27-positive gamma-delta T cell
namespace: cell
def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712]
synonym: "gammadelta27-positive" EXACT []
synonym: "gd27-positive" EXACT []
is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell
is_a: CL:0000912 ! helper T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
created_by: tmeehan
creation_date: 2010-08-18T09:57:19Z

[Term]
id: CL:0002125
name: CD27-negative gamma-delta T cell
namespace: cell
def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712]
synonym: "gammadelta-17 cells" EXACT [PMID:21976777]
is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell
is_a: CL:0000912 ! helper T cell
intersection_of: CL:0000800 ! mature gamma-delta T cell
intersection_of: capable_of GO:0032620 ! interleukin-17 production
intersection_of: has_completed GO:0030217 ! T cell differentiation
intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: capable_of GO:0032620 ! interleukin-17 production
relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell
relationship: has_completed GO:0030217 ! T cell differentiation
relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2
relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule
created_by: tmeehan
creation_date: 2010-08-18T09:57:29Z

[Term]
id: CL:0002126
name: CD25-positive, CD27-positive immature gamma-delta T cell
namespace: cell
def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712]
is_a: CL:0000799 {is_inferred="true"} ! immature gamma-delta T cell
is_a: CL:0000893 ! thymocyte
intersection_of: CL:0000799 ! immature gamma-delta T cell
intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
intersection_of: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1
intersection_of: part_of UBERON:0002370 ! thymus
relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule
relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin
relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule
relationship: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5
relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1
relationship: part_of UBERON:0002370 ! thymus
created_by: tmeehan
creation_date: 2010-08-18T10:35:37Z

[Term]
id: CL:0002127
name: innate effector T cell
namespace: cell
def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831]
is_a: CL:0000911 {is_inferred="true"} ! effector T cell
intersection_of: CL:0000911 ! effector T cell
intersection_of: capable_of GO:0045087 ! innate immune response
relationship: capable_of GO:0045087 ! innate immune response
created_by: tmeehan
creation_date: 2010-08-20T02:14:25Z

[Term]
id: CL:0002128
name: Tc17 cell
namespace: cell
def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [GOC:add, GOC:dsd, GOC:tfm, PMID:19201830, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells.  Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition).
synonym: "Tc17 CD8+ T cell" EXACT [PMID:22343568]
synonym: "Tc17 T cell" EXACT []
synonym: "Tc17 T lymphocyte" EXACT []
synonym: "Tc17 T-cell" EXACT []
synonym: "Tc17 T-lymphocyte" EXACT []
is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell
intersection_of: capable_of GO:0032620 ! interleukin-17 production
intersection_of: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5
intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: capable_of GO:0032620 ! interleukin-17 production
relationship: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5
relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6
relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA

[Term]
id: CL:0002129
name: regular atrial cardiac myocyte
namespace: cell
def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm]
synonym: "atrial cardiac muscle cell" EXACT [GOC:pr]
synonym: "atrial myocyte" EXACT []
synonym: "regular atrial cardiac muscle fiber" EXACT []
synonym: "regular cardiac muscle cell of atrium" EXACT []
xref: FMA:83108
is_a: CL:0002098 ! regular cardiac myocyte
created_by: tmeehan
creation_date: 2010-08-23T11:41:03Z

[Term]
id: CL:0002130
name: regular interatrial cardiac myocyte
namespace: cell
def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm]
xref: FMA:228790
is_a: CL:0002098 ! regular cardiac myocyte
created_by: tmeehan
creation_date: 2010-08-23T11:41:09Z

[Term]
id: CL:0002131
name: regular ventricular cardiac myocyte
namespace: cell
def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm]
synonym: "regular cardiac muscle cell of ventricle" EXACT []
synonym: "regular ventricular cardiac muscle fiber" EXACT []
synonym: "ventricular cardiac muscle cell" BROAD [GOC:pr]
synonym: "ventricular myocyte" EXACT []
xref: FMA:83109
is_a: CL:0002098 ! regular cardiac myocyte
created_by: tmeehan
creation_date: 2010-08-23T11:41:13Z

[Term]
id: CL:0002132
name: stromal cell of ovary
namespace: cell
def: "A stomal cell of the ovary" [GOC:tfm]
synonym: "ovarian stromal cell" EXACT [GOC:cjm]
xref: FMA:72299
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad
created_by: tmeehan
creation_date: 2010-08-23T12:10:31Z

[Term]
id: CL:0002133
name: stromal cell of ovarian cortex
namespace: cell
def: "A stromal cell of the ovarian cortex." [GOC:tfm]
xref: FMA:256169
is_a: CL:0002132 ! stromal cell of ovary
created_by: tmeehan
creation_date: 2010-08-23T12:12:15Z

[Term]
id: CL:0002134
name: stromal cell of ovarian medulla
namespace: cell
def: "A stromal cell of the ovarian medulla." [GOC:tfm]
xref: FMA:256171
is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0013192 ! ovarian medulla
relationship: part_of UBERON:0013192 ! ovarian medulla
created_by: tmeehan
creation_date: 2010-08-23T12:12:17Z

[Term]
id: CL:0002135
name: nonkeratinized cell of epidermis
namespace: cell
def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287]
xref: FMA:62880
is_a: CL:0000362 ! epidermal cell
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: tmeehan
creation_date: 2010-08-24T08:43:27Z

[Term]
id: CL:0002136
name: type II cell of adrenal cortex
namespace: cell
def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651]
synonym: "type II cortical cell of adrenal gland" EXACT []
xref: FMA:69547
is_a: CL:0000460 ! glucocorticoid secreting cell
is_a: CL:0002097 ! cortical cell of adrenal gland
created_by: tmeehan
creation_date: 2010-08-24T01:50:42Z

[Term]
id: CL:0002137
name: type III cell of adrenal cortex
namespace: cell
def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651]
xref: FMA:69564
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002097 ! cortical cell of adrenal gland
created_by: tmeehan
creation_date: 2010-08-24T01:50:44Z

[Term]
id: CL:0002138
name: endothelial cell of lymphatic vessel
namespace: cell
alt_id: CL:1000421
def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148]
synonym: "LEC" EXACT []
synonym: "lymphatic endothelial cell" EXACT []
xref: BTO:0004167
xref: FMA:68458
is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: develops_from CL:0005022 ! vascular lymphangioblast
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: develops_from CL:0005022 ! vascular lymphangioblast
relationship: part_of UBERON:0001473 ! lymphatic vessel
created_by: tmeehan
creation_date: 2010-08-24T02:05:28Z

[Term]
id: CL:0002139
name: endothelial cell of vascular tree
namespace: cell
def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.
synonym: "cubodial endothelial cell of vascular tree" NARROW []
synonym: "vascular endothelial cell" EXACT []
xref: BTO:0001854
xref: CALOHA:TS-1106
xref: FMA:67755
is_a: CL:0000115 ! endothelial cell
created_by: tmeehan
creation_date: 2010-08-24T02:06:40Z

[Term]
id: CL:0002140
name: acinar cell of sebaceous gland
namespace: cell
alt_id: CL:0002587
def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [GOC:tfm]
synonym: "sebocyte" BROAD []
xref: BTO:0004613
xref: FMA:70953
is_a: CL:0000317 {is_inferred="true"} ! sebum secreting cell
is_a: CL:0000622 ! acinar cell
is_a: CL:1000448 ! epithelial cell of sweat gland
intersection_of: CL:0000317 ! sebum secreting cell
intersection_of: part_of UBERON:0003487 ! skin sebaceous gland
relationship: part_of UBERON:0003487 ! skin sebaceous gland
created_by: tmeehan
creation_date: 2010-08-24T09:27:52Z

[Term]
id: CL:0002141
name: active chief cell of parathyroid gland
namespace: cell
def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm]
xref: FMA:69082
is_a: CL:0000446 ! chief cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-08-24T09:30:15Z

[Term]
id: CL:0002142
name: dark cell of eccrine sweat gland
namespace: cell
def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651]
xref: FMA:70659
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000318 ! sweat secreting cell
is_a: CL:0000434 ! eccrine cell
is_a: CL:1000448 ! epithelial cell of sweat gland
relationship: part_of UBERON:0000423 ! eccrine sweat gland
created_by: tmeehan
creation_date: 2010-08-24T02:15:16Z

[Term]
id: CL:0002143
name: dark chief cell of parathyroid cell
namespace: cell
def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544]
xref: FMA:69080
is_a: CL:0000446 ! chief cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-08-24T02:18:36Z

[Term]
id: CL:0002144
name: capillary endothelial cell
namespace: cell
def: "An endothelial cell found in capillaries." [GOC:tfm]
xref: BTO:0004956
xref: CALOHA:TS-0112
xref: FMA:67756
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001915 ! endothelium of capillary
relationship: part_of UBERON:0001915 ! endothelium of capillary
created_by: tmeehan
creation_date: 2010-08-24T10:15:00Z

[Term]
id: CL:0002145
name: ciliated columnar cell of tracheobronchial tree
namespace: cell
def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651]
xref: FMA:70542
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0005012 ! multi-ciliated epithelial cell
relationship: develops_from CL:0002209 ! intermediate epitheliocyte
created_by: tmeehan
creation_date: 2010-08-24T03:38:29Z

[Term]
id: CL:0002146
name: clear cell of eccrine sweat gland
namespace: cell
def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651]
xref: FMA:70658
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000318 ! sweat secreting cell
is_a: CL:0000434 ! eccrine cell
is_a: CL:1000448 ! epithelial cell of sweat gland
relationship: part_of UBERON:0000423 ! eccrine sweat gland
created_by: tmeehan
creation_date: 2010-08-24T10:33:02Z

[Term]
id: CL:0002147
name: clear chief cell of parathyroid cell
namespace: cell
def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256]
xref: FMA:69081
is_a: CL:0000446 ! chief cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-08-24T10:39:42Z

[Term]
id: CL:0002148
name: dental pulp cell
namespace: cell
def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820]
xref: BTO:0000339
xref: CALOHA:TS-0195
xref: FMA:87170
is_a: CL:0002159 ! general ecto-epithelial cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: part_of UBERON:0001754 ! dental pulp
relationship: part_of UBERON:0001754 ! dental pulp
created_by: tmeehan
creation_date: 2010-08-24T02:52:09Z

[Term]
id: CL:0002149
name: epithelial cell of uterus
namespace: cell
alt_id: CL:1000294
def: "An epithelial cell of the uterus." [GOC:tfm]
xref: FMA:256161
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus
created_by: tmeehan
creation_date: 2010-08-24T10:45:54Z

[Term]
id: CL:0002150
name: epithelioid macrophage
namespace: cell
def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [MESH:A11.329.372.300, PMID:12673090]
synonym: "epithelioid cell" BROAD []
synonym: "epithelioid histocyte" EXACT [MESH:A11.329.372.300, PMID:12673090]
synonym: "epitheloid macrophage" EXACT []
xref: FMA:83514
is_a: CL:0000235 ! macrophage
relationship: develops_from CL:0000861 ! elicited macrophage
created_by: tmeehan
creation_date: 2010-08-24T03:48:30Z

[Term]
id: CL:0002151
name: late promyelocyte
namespace: cell
def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [ISBN:0412046911]
xref: FMA:83534
is_a: CL:0000836 ! promyelocyte
created_by: tmeehan
creation_date: 2010-08-24T03:07:50Z

[Term]
id: CL:0002152
name: columnar cell of endocervix
namespace: cell
def: "A columnar cell of the cervix uteri." [GOC:tfm, ISBN:0721662544]
xref: FMA:86486
is_a: CL:0002149 ! epithelial cell of uterus
relationship: part_of UBERON:0000458 ! endocervix
created_by: tmeehan
creation_date: 2010-08-24T10:47:47Z

[Term]
id: CL:0002153
name: corneocyte
namespace: cell
def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X]
xref: BTO:0001943
xref: FMA:68650
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000311 ! keratin accumulating cell
relationship: develops_from CL:0000312 ! keratinocyte
relationship: part_of UBERON:0002027 ! stratum corneum of epidermis
created_by: tmeehan
creation_date: 2010-08-24T10:53:03Z

[Term]
id: CL:0002154
name: early promyelocyte
namespace: cell
def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm]
xref: FMA:83533
is_a: CL:0000836 ! promyelocyte
created_by: tmeehan
creation_date: 2010-08-24T03:07:53Z

[Term]
id: CL:0002155
name: echinocyte
namespace: cell
def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm]
synonym: "burr cell" EXACT []
xref: FMA:81099
is_a: CL:0000595 ! enucleate erythrocyte
created_by: tmeehan
creation_date: 2010-08-24T03:15:21Z

[Term]
id: CL:0002157
name: endosteal cell
namespace: cell
def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm]
xref: FMA:86495
is_a: CL:0001035 ! bone cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: part_of UBERON:0009859 ! endosteum
created_by: tmeehan
creation_date: 2010-08-24T03:33:58Z

[Term]
id: CL:0002158
name: external epithelial cell of tympanic membrane
namespace: cell
def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391]
xref: FMA:70558
is_a: CL:0002159 ! general ecto-epithelial cell
created_by: tmeehan
creation_date: 2010-08-25T10:25:31Z

[Term]
id: CL:0002159
name: general ecto-epithelial cell
namespace: cell
def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm]
xref: FMA:70556
is_a: CL:0002077 ! ecto-epithelial cell
created_by: tmeehan
creation_date: 2010-08-26T08:31:08Z

[Term]
id: CL:0002160
name: basal external epithelial cell of tympanic membrane
namespace: cell
def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391]
is_a: CL:0002158 ! external epithelial cell of tympanic membrane
created_by: tmeehan
creation_date: 2010-08-25T10:28:44Z

[Term]
id: CL:0002161
name: superficial external epithelial cell of tympanic membrane
namespace: cell
def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391]
is_a: CL:0002158 ! external epithelial cell of tympanic membrane
created_by: tmeehan
creation_date: 2010-08-25T10:28:48Z

[Term]
id: CL:0002162
name: internal epithelial cell of tympanic membrane
namespace: cell
def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm]
xref: FMA:70626
is_a: CL:0002076 ! endo-epithelial cell
relationship: part_of UBERON:0002364 ! tympanic membrane
created_by: tmeehan
creation_date: 2010-08-25T10:49:46Z

[Term]
id: CL:0002163
name: internal pillar cell of cochlea
namespace: cell
def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html]
xref: FMA:75722
xref: FMA:75726
is_a: CL:1000191 ! pillar cell
created_by: tmeehan
creation_date: 2010-08-25T11:05:21Z

[Term]
id: CL:0002164
name: external pillar cell of cochlea
namespace: cell
def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html]
xref: FMA:75727
is_a: CL:1000191 ! pillar cell
created_by: tmeehan
creation_date: 2010-08-25T11:05:23Z

[Term]
id: CL:0002165
name: phalangeal cell
namespace: cell
def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256]
xref: FMA:79800
is_a: CL:0002490 ! organ of Corti supporting cell
created_by: tmeehan
creation_date: 2010-08-25T01:29:07Z

[Term]
id: CL:0002166
name: epithelial cell of Malassez
namespace: cell
def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521]
synonym: "epithelial cell rests of Malassez " EXACT []
synonym: "epithelial debris of Malassez" EXACT []
xref: FMA:62987
is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
relationship: part_of UBERON:0011595 ! jaw region
created_by: tmeehan
creation_date: 2010-08-26T08:51:27Z

[Term]
id: CL:0002167
name: olfactory epithelial cell
namespace: cell
def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026]
xref: FMA:67870
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
created_by: tmeehan
creation_date: 2010-08-26T01:47:13Z

[Term]
id: CL:0002168
name: border cell of cochlea
namespace: cell
def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm]
xref: FMA:79798
is_a: CL:0002315 ! supporting cell of cochlea
created_by: tmeehan
creation_date: 2010-08-25T01:47:12Z

[Term]
id: CL:0002169
name: basal cell of olfactory epithelium
namespace: cell
alt_id: CL:1000395
def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026]
synonym: "horizontal basal call" BROAD []
xref: FMA:62303
is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002167 ! olfactory epithelial cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium
relationship: part_of UBERON:0001997 ! olfactory epithelium
created_by: tmeehan
creation_date: 2010-08-26T01:58:54Z

[Term]
id: CL:0002170
name: keratinized cell of the oral mucosa
namespace: cell
def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572]
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
is_a: CL:0002336 ! buccal mucosa cell
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0003729 ! mouth mucosa
relationship: part_of UBERON:0003729 ! mouth mucosa
created_by: tmeehan
creation_date: 2010-08-26T02:51:30Z

[Term]
id: CL:0002171
name: globose cell of olfactory epithelium
namespace: cell
def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753]
synonym: "blastema cell of olfactory epithelium" EXACT []
xref: FMA:67874
is_a: CL:0002169 ! basal cell of olfactory epithelium
created_by: tmeehan
creation_date: 2010-08-26T01:59:18Z

[Term]
id: CL:0002172
name: interdental cell of cochlea
namespace: cell
def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803]
synonym: "interdental cell" EXACT []
xref: FMA:79797
is_a: CL:0002315 ! supporting cell of cochlea
relationship: part_of UBERON:0002276 ! lamina of spiral limbus
created_by: tmeehan
creation_date: 2010-08-25T02:02:48Z

[Term]
id: CL:0002173
name: extraglomerular mesangial cell
namespace: cell
def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911]
synonym: "Goormaghtigh cell" EXACT []
synonym: "lacis cell" RELATED []
synonym: "polar cushion cells" EXACT []
xref: FMA:84143
xref: KUPO:0001033
is_a: CL:0000650 ! mesangial cell
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell
is_a: CL:1000746 ! glomerular cell
is_a: CL:1001318 ! renal interstitial pericyte
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium
relationship: part_of UBERON:0002321 ! extraglomerular mesangium
created_by: tmeehan
creation_date: 2010-08-25T02:20:55Z

[Term]
id: CL:0002174
name: follicular cell of ovary
namespace: cell
def: "A cell within the follicle of an ovary." [GOC:tfm]
xref: EMAPA:31247
xref: FMA:70589
is_a: CL:0002078 ! meso-epithelial cell
created_by: tmeehan
creation_date: 2010-08-25T03:01:27Z

[Term]
id: CL:0002175
name: primary follicular cell of ovary
namespace: cell
def: "A cell within the primary follicle of the ovary." [GOC:tfm]
xref: FMA:70590
is_a: CL:0002174 ! follicular cell of ovary
created_by: tmeehan
creation_date: 2010-08-25T03:03:42Z

[Term]
id: CL:0002176
name: secondary follicular cell of ovary
namespace: cell
def: "A cell of a secondary follicile within the ovary." [GOC:tfm]
xref: FMA:70591
is_a: CL:0002174 ! follicular cell of ovary
created_by: tmeehan
creation_date: 2010-08-25T03:03:48Z

[Term]
id: CL:0002177
name: folliculostellate cell of pars distalis of adenohypophysis
namespace: cell
def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm]
synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT []
xref: FMA:83102
is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000642 ! folliculostellate cell
intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis
relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis
created_by: tmeehan
creation_date: 2010-08-25T03:10:10Z

[Term]
id: CL:0002178
name: epithelial cell of stomach
namespace: cell
alt_id: CL:1000399
def: "An epithelial cell found in the lining of the stomach." [GOC:tfm]
xref: FMA:62948
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
created_by: tmeehan
creation_date: 2010-08-25T03:22:08Z

[Term]
id: CL:0002179
name: foveolar cell of stomach
namespace: cell
def: "An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ." [GOC:tfm, http://www.merriam-webster.com/medical/foveolar]
xref: FMA:86552
is_a: CL:0002178 ! epithelial cell of stomach
created_by: tmeehan
creation_date: 2010-08-25T03:23:22Z

[Term]
id: CL:0002180
name: mucous cell of stomach
namespace: cell
alt_id: CL:1000404
def: "A mucous cell in the epithelium of the stomach." [GOC:tfm]
xref: FMA:63464
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0002178 ! epithelial cell of stomach
intersection_of: part_of UBERON:0001199 ! mucosa of stomach
relationship: part_of UBERON:0001199 ! mucosa of stomach
created_by: tmeehan
creation_date: 2010-08-25T03:38:51Z

[Term]
id: CL:0002181
name: mucus neck cell of gastric gland
namespace: cell
alt_id: CL:1000401
def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651]
xref: FMA:62954
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000651 {is_inferred="true"} ! mucous neck cell
is_a: CL:0002180 {is_inferred="true"} ! mucous cell of stomach
intersection_of: CL:0000651 ! mucous neck cell
intersection_of: part_of UBERON:0000325 ! gastric gland
relationship: part_of UBERON:0000325 ! gastric gland
created_by: tmeehan
creation_date: 2010-08-25T03:41:30Z

[Term]
id: CL:0002182
name: surface mucosal cell of stomach
namespace: cell
def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651]
xref: FMA:62949
is_a: CL:0000319 ! mucus secreting cell
is_a: CL:0002180 ! mucous cell of stomach
relationship: capable_of GO:0070254 ! mucus secretion
created_by: tmeehan
creation_date: 2010-08-25T03:45:10Z

[Term]
id: CL:0002183
name: stem cell of gastric gland
namespace: cell
alt_id: CL:1000400
def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651]
xref: FMA:62953
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002180 ! mucous cell of stomach
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0000325 ! gastric gland
relationship: part_of UBERON:0000325 ! gastric gland
created_by: tmeehan
creation_date: 2010-08-25T03:57:08Z

[Term]
id: CL:0002184
name: basal proper cell of olfactory epithelium
namespace: cell
def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623]
synonym: "horizontal basal cells" EXACT []
xref: FMA:62304
is_a: CL:0002169 ! basal cell of olfactory epithelium
created_by: tmeehan
creation_date: 2010-08-26T01:59:22Z

[Term]
id: CL:0002187
name: basal cell of epidermis
namespace: cell
alt_id: CL:1000439
def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [GOC:tfm, ISBN:0517223651]
xref: FMA:70571
is_a: CL:0000312 ! keratinocyte
is_a: CL:0000646 {is_inferred="true"} ! basal cell
is_a: CL:1000428 ! stem cell of epidermis
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: tmeehan
creation_date: 2010-08-26T03:12:49Z

[Term]
id: CL:0002188
name: glomerular endothelial cell
namespace: cell
def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009]
xref: BTO:0004632
xref: FMA:70970
is_a: CL:0000115 {is_inferred="true"} ! endothelial cell
is_a: CL:0000666 ! fenestrated cell
is_a: CL:1000746 ! glomerular cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus
created_by: tmeehan
creation_date: 2010-08-26T10:59:44Z

[Term]
id: CL:0002189
name: granular cell of epidermis
namespace: cell
def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [ISBN:1416031855]
xref: FMA:70543
is_a: CL:0000312 ! keratinocyte
created_by: tmeehan
creation_date: 2010-08-26T03:19:00Z

[Term]
id: CL:0002190
name: squamous cell of epidermis
namespace: cell
def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651]
xref: FMA:86925
is_a: CL:0000312 ! keratinocyte
created_by: tmeehan
creation_date: 2010-08-26T03:37:02Z

[Term]
id: CL:0002191
name: granulocytopoietic cell
namespace: cell
def: "A cell involved in the formation of a granulocyte." [GOC:tfm]
xref: FMA:83519
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0030851 ! granulocyte differentiation
relationship: capable_of GO:0030851 ! granulocyte differentiation
created_by: tmeehan
creation_date: 2010-08-30T12:54:27Z

[Term]
id: CL:0002192
name: metamyelocyte
namespace: cell
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, http://en.wikipedia.org/wiki/Metamyelocyte, ISBN:0721601464]
xref: FMA:83541
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
relationship: develops_from CL:0002193 ! myelocyte
created_by: tmeehan
creation_date: 2010-08-30T01:08:15Z

[Term]
id: CL:0002193
name: myelocyte
namespace: cell
def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, http://en.wikipedia.org/wiki/Myelocyte, ISBN:0323052908]
xref: BTO:0000734
xref: FMA:83525
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
relationship: develops_from CL:0000836 ! promyelocyte
created_by: tmeehan
creation_date: 2010-08-30T01:08:19Z

[Term]
id: CL:0002194
name: monopoietic cell
namespace: cell
def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm]
xref: FMA:83552
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
relationship: capable_of GO:0030224 ! monocyte differentiation
created_by: tmeehan
creation_date: 2010-08-30T01:27:48Z

[Term]
id: CL:0002195
name: hepatic stem cell
namespace: cell
def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm]
xref: FMA:86577
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
created_by: tmeehan
creation_date: 2010-08-30T02:00:42Z

[Term]
id: CL:0002196
name: hepatic oval stem cell
namespace: cell
alt_id: CL:1000036
def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986]
synonym: "hepatic oval cell" EXACT []
xref: BTO:0004270
xref: FMA:86576
is_a: CL:0002195 ! hepatic stem cell
created_by: tmeehan
creation_date: 2010-08-30T02:01:49Z

[Term]
id: CL:0002197
name: inactive chief cell of parathyoid gland
namespace: cell
def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651]
is_a: CL:0000446 ! chief cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-09-02T11:14:01Z

[Term]
id: CL:0002198
name: oncocyte
namespace: cell
def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317]
synonym: "oxyphil" EXACT []
xref: FMA:67606
is_a: CL:0002076 ! endo-epithelial cell
created_by: tmeehan
creation_date: 2010-09-02T11:26:49Z

[Term]
id: CL:0002199
name: oxyphil cell of parathyroid gland
namespace: cell
def: "An oncocyte located in the parathyroid gland." [PMID:20013317]
xref: FMA:69084
is_a: CL:0002198 ! oncocyte
is_a: CL:0002260 ! epithelial cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-09-02T11:33:23Z

[Term]
id: CL:0002200
name: oxyphil cell of thyroid
namespace: cell
def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317]
synonym: "Askanazy cells" EXACT []
synonym: "Hurthle cells" EXACT []
xref: FMA:87169
is_a: CL:0002198 ! oncocyte
is_a: CL:0002257 ! epithelial cell of thyroid gland
intersection_of: CL:0002198 ! oncocyte
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland
created_by: tmeehan
creation_date: 2010-09-02T11:33:26Z

[Term]
id: CL:0002201
name: renal beta-intercalated cell
namespace: cell
def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [GOC:tfm, PMID:11781354]
is_a: CL:0005010 ! renal intercalated cell
created_by: tmeehan
creation_date: 2010-09-02T01:43:55Z

[Term]
id: CL:0002202
name: epithelial cell of tracheobronchial tree
namespace: cell
alt_id: CL:1000407
def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm]
xref: FMA:66816
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: part_of UBERON:0007196 ! tracheobronchial tree
created_by: tmeehan
creation_date: 2010-09-02T02:09:14Z

[Term]
id: CL:0002203
name: Brush cell of epithelium proper of large intestine
namespace: cell
alt_id: CL:1000387
def: "Brush cell found in the epithelial layer of the colon." [GOC:tfm]
comment: Brush cells are a distinct cell type from brush border cell-types.
xref: FMA:263222
is_a: CL:0002204 ! brush cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0002204 ! brush cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
created_by: tmeehan
creation_date: 2010-09-02T02:20:50Z

[Term]
id: CL:0002204
name: brush cell
namespace: cell
def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [GOC:tfm, ISBN:0517223651, PMID:15817800]
synonym: "caveolated cell" EXACT []
synonym: "fibrillovesicular cell" EXACT []
synonym: "multivesicular cell" EXACT []
synonym: "tuft cell" EXACT []
xref: FMA:67978
is_a: CL:0002076 ! endo-epithelial cell
created_by: tmeehan
creation_date: 2010-09-02T02:28:53Z

[Term]
id: CL:0002205
name: brush cell of lobular bronchiole
namespace: cell
alt_id: CL:1000386
def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm]
xref: FMA:263220
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002208 ! brush cell of bronchus
intersection_of: CL:0002075 ! brush cell of trachebronchial tree
intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole
relationship: part_of UBERON:0002051 ! epithelium of bronchiole
created_by: tmeehan
creation_date: 2010-09-02T02:38:34Z

[Term]
id: CL:0002206
name: brush cell of terminal bronchiole
namespace: cell
alt_id: CL:1000390
def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm]
xref: FMA:263228
is_a: CL:0002205 ! brush cell of lobular bronchiole
intersection_of: CL:0002075 ! brush cell of trachebronchial tree
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium
created_by: tmeehan
creation_date: 2010-09-02T02:38:36Z

[Term]
id: CL:0002207
name: brush cell of trachea
namespace: cell
alt_id: CL:1000388
def: "Brush cell of the epithelium in the trachea." [GOC:tfm]
xref: FMA:263224
is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell
is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree
intersection_of: CL:0002204 ! brush cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
created_by: tmeehan
creation_date: 2010-09-02T02:38:37Z

[Term]
id: CL:0002208
name: brush cell of bronchus
namespace: cell
alt_id: CL:1000389
def: "A brush cell found in the epithelium of bronchus." [GOC:tfm]
xref: FMA:263226
is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree
is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell
intersection_of: CL:0002075 ! brush cell of trachebronchial tree
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
created_by: tmeehan
creation_date: 2010-09-02T02:38:42Z

[Term]
id: CL:0002209
name: intermediate epitheliocyte
namespace: cell
def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651]
synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT []
xref: FMA:69060
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
created_by: tmeehan
creation_date: 2010-09-02T02:53:59Z

[Term]
id: CL:0002210
name: red muscle cell
namespace: cell
def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651]
synonym: "oxidative muscle fiber" EXACT []
synonym: "red muscle fiber" EXACT []
xref: FMA:84448
is_a: CL:0008002 ! skeletal muscle fiber
created_by: tmeehan
creation_date: 2010-09-02T03:20:03Z

[Term]
id: CL:0002211
name: type I muscle cell
namespace: cell
def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651]
synonym: "intermediate muscle fiber" RELATED [MESH:A02.633.565.700]
synonym: "slow twitch fiber" EXACT []
synonym: "slow twitch muscle cell" EXACT []
synonym: "slow twitch muscle fiber" RELATED [MESH:A02.633.565.700]
synonym: "slow-twitch muscle fiber" RELATED [MESH:A02.633.565.700]
synonym: "type 1 muscle cell" EXACT []
synonym: "type 1 muscle fiber" EXACT []
synonym: "type I muscle fiber" EXACT []
xref: BTO:0001812
xref: CALOHA:TS-0940
xref: FMA:84413
xref: MESH:A02.633.565.700
is_a: CL:0000189 ! slow muscle cell
is_a: CL:0002210 ! red muscle cell
created_by: tmeehan
creation_date: 2010-09-02T03:24:05Z

[Term]
id: CL:0002212
name: type II muscle cell
namespace: cell
def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm]
synonym: "type 2 muscle cell" EXACT []
synonym: "type 2 muscle fiber" EXACT []
synonym: "type II muscle fiber" EXACT []
xref: BTO:0001813
xref: FMA:84414
is_a: CL:0000190 ! fast muscle cell
created_by: tmeehan
creation_date: 2010-09-02T03:28:45Z

[Term]
id: CL:0002213
name: white muscle cell
namespace: cell
def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651]
xref: FMA:84449
is_a: CL:0000190 ! fast muscle cell
created_by: tmeehan
creation_date: 2010-09-02T03:28:48Z

[Term]
id: CL:0002214
name: type IIa muscle cell
namespace: cell
def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm]
synonym: "fast twitch A" EXACT []
synonym: "fatigue resistant fast twitch muscle cell" EXACT []
synonym: "type 2a muscle cell" EXACT []
synonym: "type 2a muscle fiber" EXACT []
synonym: "type IIa muscle fiber" EXACT []
xref: BTO:0001813
xref: FMA:84415
is_a: CL:0002210 ! red muscle cell
is_a: CL:0002212 ! type II muscle cell
created_by: tmeehan
creation_date: 2010-09-02T03:31:38Z

[Term]
id: CL:0002215
name: type IIb muscle cell
namespace: cell
def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651]
synonym: "type 2b muscle cell" EXACT []
synonym: "type 2b muscle fiber" EXACT []
synonym: "type IIb muscle fiber" EXACT []
xref: FMA:84416
is_a: CL:0002212 ! type II muscle cell
is_a: CL:0002213 ! white muscle cell
created_by: tmeehan
creation_date: 2010-09-02T03:31:42Z

[Term]
id: CL:0002216
name: intermediate muscle cell
namespace: cell
def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm]
xref: FMA:84450
is_a: CL:0008002 ! skeletal muscle fiber
created_by: tmeehan
creation_date: 2010-09-02T03:51:17Z

[Term]
id: CL:0002217
name: intermediate trophoblast cell
namespace: cell
def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html]
xref: BTO:0002366
xref: FMA:86564
is_a: CL:0000351 ! trophoblast cell
created_by: tmeehan
creation_date: 2010-09-02T04:04:36Z

[Term]
id: CL:0002218
name: immature dendritic epithelial T cell precursor
namespace: cell
def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "immature DEC precursor" EXACT []
synonym: "immature DETC precursor" EXACT []
is_a: CL:0002404 ! fetal thymocyte
created_by: tmeehan
creation_date: 2010-10-07T01:58:00Z

[Term]
id: CL:0002219
name: anchoring trophoblast
namespace: cell
def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html]
is_a: CL:0000351 ! trophoblast cell
created_by: tmeehan
creation_date: 2010-09-02T04:14:28Z

[Term]
id: CL:0002220
name: interstitial cell of pineal gland
namespace: cell
def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651]
xref: FMA:86575
is_a: CL:0000710 ! neurecto-epithelial cell
created_by: tmeehan
creation_date: 2010-09-02T04:28:41Z

[Term]
id: CL:0002221
name: keratinized squamous cell of esophagus
namespace: cell
def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559]
xref: FMA:86549
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0002252 ! epithelial cell of esophagus
created_by: tmeehan
creation_date: 2010-09-07T10:11:06Z

[Term]
id: CL:0002222
name: vertebrate lens cell
namespace: cell
def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544]
xref: FMA:70950
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000306 ! crystallin accumulating cell
is_a: CL:0002371 ! somatic cell
relationship: part_of UBERON:0000965 ! lens of camera-type eye
created_by: tmeehan
creation_date: 2010-09-07T10:38:03Z

[Term]
id: CL:0002223
name: anterior lens cell
namespace: cell
def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651]
xref: FMA:63181
is_a: CL:0002224 ! lens epithelial cell
created_by: tmeehan
creation_date: 2010-09-07T10:45:45Z

[Term]
id: CL:0002224
name: lens epithelial cell
namespace: cell
def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
xref: FMA:67559
is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell
is_a: CL:0002222 ! vertebrate lens cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: part_of UBERON:0001803 ! epithelium of lens
relationship: part_of UBERON:0001803 ! epithelium of lens
created_by: tmeehan
creation_date: 2010-09-07T10:45:47Z

[Term]
id: CL:0002225
name: secondary lens fiber
namespace: cell
def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651]
synonym: "secondary lens fibre" EXACT []
is_a: CL:0011004 ! lens fiber cell
relationship: develops_from CL:0002228 ! primary lens fiber
created_by: tmeehan
creation_date: 2010-09-07T10:53:39Z

[Term]
id: CL:0002226
name: non-nucleated secondary lens fiber
namespace: cell
def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm]
synonym: "non-nucleated secondary lens fibre" EXACT []
xref: FMA:67561
is_a: CL:0002225 ! secondary lens fiber
relationship: develops_from CL:0002227 ! nucleated secondary lens fiber
created_by: tmeehan
creation_date: 2010-09-07T11:15:23Z

[Term]
id: CL:0002227
name: nucleated secondary lens fiber
namespace: cell
def: "A secondary fiber cell that contains a nucleus." [GOC:tfm]
synonym: "nucleated secondary lens fibre" EXACT []
xref: FMA:70949
is_a: CL:0002225 ! secondary lens fiber
created_by: tmeehan
creation_date: 2010-09-07T11:15:26Z

[Term]
id: CL:0002228
name: primary lens fiber
namespace: cell
def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704]
synonym: "primary lens fibre" EXACT []
xref: FMA:70613
is_a: CL:0011004 ! lens fiber cell
relationship: develops_from CL:0002223 ! anterior lens cell
created_by: tmeehan
creation_date: 2010-09-07T11:19:01Z

[Term]
id: CL:0002229
name: light chief cell of parathyroid gland
namespace: cell
def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544]
xref: FMA:69079
is_a: CL:0000446 ! chief cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-09-07T11:46:54Z

[Term]
id: CL:0002231
name: epithelial cell of prostate
namespace: cell
alt_id: CL:1000295
alt_id: CL:1000408
def: "An epithelial cell of the prostate." [GOC:tfm]
synonym: "prostate epithelial cell" EXACT []
xref: FMA:256163
xref: FMA:66817
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
created_by: tmeehan
creation_date: 2010-09-07T01:49:29Z

[Term]
id: CL:0002232
name: epithelial cell of prostatic duct
namespace: cell
alt_id: CL:1000462
def: "An epithelial cell of prostatic duct." [GOC:tfm]
synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224]
xref: FMA:74224
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
is_a: CL:0002231 ! epithelial cell of prostate
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0002485 ! prostate duct
relationship: part_of UBERON:0002485 ! prostate duct
created_by: tmeehan
creation_date: 2010-09-07T01:55:51Z

[Term]
id: CL:0002233
name: epithelial cell of prostatic acinus
namespace: cell
alt_id: CL:1000461
def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349]
synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223]
xref: FMA:74223
is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate
intersection_of: CL:0002231 ! epithelial cell of prostate
intersection_of: part_of UBERON:0004179 ! prostate glandular acinus
relationship: part_of UBERON:0004179 ! prostate glandular acinus
created_by: tmeehan
creation_date: 2010-09-07T01:55:53Z

[Term]
id: CL:0002234
name: basal cell of prostatic acinus
namespace: cell
alt_id: CL:1000464
def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm]
synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265]
xref: FMA:74265
is_a: CL:0002233 ! epithelial cell of prostatic acinus
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0002341 ! basal cell of prostate epithelium
intersection_of: part_of UBERON:0004179 ! prostate glandular acinus
relationship: part_of UBERON:0004179 ! prostate glandular acinus
created_by: tmeehan
creation_date: 2010-09-07T01:59:08Z

[Term]
id: CL:0002235
name: luminal cell of prostatic acinus
namespace: cell
def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [GOC:tfm]
xref: FMA:74266
is_a: CL:0002233 ! epithelial cell of prostatic acinus
is_a: CL:0002340 ! luminal cell of prostate epithelium
intersection_of: CL:0002340 ! luminal cell of prostate epithelium
intersection_of: part_of UBERON:0004179 ! prostate glandular acinus
relationship: part_of UBERON:0004179 ! prostate glandular acinus
created_by: tmeehan
creation_date: 2010-09-07T01:59:10Z

[Term]
id: CL:0002236
name: basal epithelial cell of prostatic duct
namespace: cell
alt_id: CL:1000463
def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377]
xref: FMA:74226
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0002341 ! basal cell of prostate epithelium
intersection_of: part_of UBERON:0002485 ! prostate duct
relationship: part_of UBERON:0002485 ! prostate duct
created_by: tmeehan
creation_date: 2010-09-07T01:59:12Z

[Term]
id: CL:0002237
name: luminal epithelial cell of prostatic duct
namespace: cell
def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm]
xref: FMA:74225
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002340 ! luminal cell of prostate epithelium
intersection_of: CL:0002340 ! luminal cell of prostate epithelium
intersection_of: part_of UBERON:0002485 ! prostate duct
relationship: part_of UBERON:0002485 ! prostate duct
created_by: tmeehan
creation_date: 2010-09-07T01:59:16Z

[Term]
id: CL:0002238
name: male gonocyte
namespace: cell
def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm]
synonym: "male primordial germ cell" EXACT []
synonym: "testis primordial germ cell" EXACT [VHOG:0000662]
xref: EHDAA2:0001053
xref: EMAPA:18686
xref: FMA:84771
xref: VHOG:0000662
is_a: CL:0000670 ! primordial germ cell
relationship: part_of UBERON:0000473 ! testis
created_by: tmeehan
creation_date: 2010-09-07T02:11:13Z

[Term]
id: CL:0002239
name: ooblast
namespace: cell
def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm]
synonym: "ovary primordial germ cell" EXACT [VHOG:0000661]
synonym: "ovigerm" EXACT [FMA:84772]
xref: EHDAA2:0000505
xref: EMAPA:17965
xref: FMA:84772
xref: ISBN:0721662544
xref: VHOG:0000661
is_a: CL:0000670 ! primordial germ cell
relationship: part_of UBERON:0000992 ! female gonad
created_by: tmeehan
creation_date: 2010-09-07T02:11:16Z

[Term]
id: CL:0002240
name: marrow fibroblast
namespace: cell
def: "A fibroblast in the bone marrow." [GOC:tfm]
xref: FMA:84377
is_a: CL:0000057 ! fibroblast
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: tmeehan
creation_date: 2010-09-07T02:25:18Z

[Term]
id: CL:0002241
name: pulmonary interstitial fibroblast
namespace: cell
def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm]
synonym: "pulmonary myofibroblast" EXACT []
synonym: "pulmonary septal cell" EXACT []
xref: FMA:84467
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001004 ! respiratory system
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0005169 ! interstitial tissue
created_by: tmeehan
creation_date: 2010-09-07T02:29:38Z

[Term]
id: CL:0002242
name: nucleate cell
namespace: cell
def: "A cell containing at least one nucleus." [GOC:tfm]
xref: FMA:67513
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: has_part GO:0005634 ! nucleus
relationship: has_part GO:0005634 ! nucleus
created_by: tmeehan
creation_date: 2010-09-07T03:32:33Z

[Term]
id: CL:0002243
name: smooth muscle cell of sphincter of pupil
namespace: cell
def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128]
synonym: "smooth muscle fiber of sphincter of pupil" EXACT []
synonym: "smooth muscle fibre of sphincter of pupil" RELATED []
xref: FMA:70611
is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001607 ! sphincter pupillae
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0001607 ! sphincter pupillae
created_by: tmeehan
creation_date: 2010-09-08T08:53:42Z

[Term]
id: CL:0002244
name: squamous cell of ectocervix
namespace: cell
def: "A nonstratified squamous cell located in the ectocervix." [GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm]
synonym: "ectocervical squamous cell" EXACT []
xref: FMA:86483
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002149 ! epithelial cell of uterus
created_by: tmeehan
creation_date: 2010-09-08T09:12:23Z

[Term]
id: CL:0002245
name: obsolete null lymphocyte
namespace: cell
def: "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X]
xref: FMA:83601
is_obsolete: true
created_by: tmeehan
creation_date: 2010-09-07T03:43:42Z

[Term]
id: CL:0002246
name: peripheral blood stem cell
namespace: cell
def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm]
synonym: "PBSC" EXACT []
xref: BTO:0002669
xref: FMA:86711
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
is_a: CL:0000080 ! circulating cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000178 ! blood
relationship: part_of UBERON:0000178 ! blood
created_by: tmeehan
creation_date: 2010-09-07T03:57:09Z

[Term]
id: CL:0002247
name: pleural macrophage
namespace: cell
def: "A tissue macrophage that is in the pleural space." [GOC:tfm]
xref: FMA:83024
is_a: CL:0000864 ! tissue-resident macrophage
created_by: tmeehan
creation_date: 2010-09-07T04:16:43Z

[Term]
id: CL:0002248
name: pluripotent stem cell
namespace: cell
def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304]
xref: FMA:70570
is_a: CL:0000723 ! somatic stem cell
created_by: tmeehan
creation_date: 2010-09-07T04:26:06Z

[Term]
id: CL:0002249
name: primitive cardiac myocyte
namespace: cell
def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308]
xref: FMA:75620
is_a: CL:0000035 ! single fate stem cell
is_a: CL:0002078 ! meso-epithelial cell
created_by: tmeehan
creation_date: 2010-09-07T04:40:32Z

[Term]
id: CL:0002250
name: intestinal crypt stem cell
namespace: cell
def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [GOC:tfm, ISBN:0517223651]
synonym: "stem cell of intestinal crypt of Lieberkuhn" EXACT []
xref: FMA:63379
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn
relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn
created_by: tmeehan
creation_date: 2010-09-08T09:21:22Z

[Term]
id: CL:0002251
name: epithelial cell of alimentary canal
namespace: cell
def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544]
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract
created_by: tmeehan
creation_date: 2010-09-08T09:26:53Z

[Term]
id: CL:0002252
name: epithelial cell of esophagus
namespace: cell
alt_id: CL:1000402
def: "An epithelial cell of the esophagus." [GOC:tfm]
xref: FMA:63071
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
created_by: tmeehan
creation_date: 2010-09-08T09:28:20Z

[Term]
id: CL:0002253
name: epithelial cell of large intestine
namespace: cell
alt_id: CL:1000292
def: "An epithelial cell of the large intestine." [GOC:tfm]
synonym: "epithelial cell of colon" RELATED []
xref: BTO:0004297
xref: FMA:256157
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
created_by: tmeehan
creation_date: 2010-09-08T09:28:22Z

[Term]
id: CL:0002254
name: epithelial cell of small intestine
namespace: cell
alt_id: CL:1000293
def: "An epithelial cell of the small intestine." [GOC:tfm]
xref: FMA:256159
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine
created_by: tmeehan
creation_date: 2010-09-08T09:41:46Z

[Term]
id: CL:0002255
name: stromal cell of endometrium
namespace: cell
def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [GOC:tfm, PMID:11331626]
xref: CALOHA:TS-1266
xref: FMA:86490
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
is_a: CL:0002149 ! epithelial cell of uterus
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium
created_by: tmeehan
creation_date: 2010-09-08T09:50:04Z

[Term]
id: CL:0002256
name: supporting cell of carotid body
namespace: cell
def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136]
synonym: "carotid body sustentacular cell" EXACT []
xref: FMA:84188
is_a: CL:0000630 ! supportive cell
is_a: CL:0000710 ! neurecto-epithelial cell
created_by: tmeehan
creation_date: 2010-09-08T10:34:45Z

[Term]
id: CL:0002257
name: epithelial cell of thyroid gland
namespace: cell
alt_id: CL:1000297
def: "An epithelial cell of thyroid gland." [GOC:tfm]
xref: FMA:256167
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland
created_by: tmeehan
creation_date: 2010-09-08T01:46:51Z

[Term]
id: CL:0002258
name: thyroid follicular cell
namespace: cell
def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [GOC:tfm, ISBN:0517223651]
synonym: "follicular cell of thyroid gland" EXACT []
synonym: "principal cell of thyroid gland" EXACT []
synonym: "thyroid gland follicular cell" EXACT []
xref: BTO:0003736
xref: CALOHA:TS-1285
xref: FMA:68782
is_a: CL:0002257 ! epithelial cell of thyroid gland
created_by: tmeehan
creation_date: 2010-09-08T01:50:08Z

[Term]
id: CL:0002259
name: neuroepithelial stem cell
namespace: cell
def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496]
synonym: "totipotent neuroepithelial stem cell" NARROW []
xref: FMA:87171
is_a: CL:0000723 ! somatic stem cell
created_by: tmeehan
creation_date: 2010-09-08T02:14:14Z

[Term]
id: CL:0002260
name: epithelial cell of parathyroid gland
namespace: cell
alt_id: CL:1000429
def: "An epithelial cell of the parathyroid gland." [GOC:tfm]
xref: FMA:70547
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
is_a: CL:1001593 ! parathyroid glandular cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: part_of UBERON:0001132 ! parathyroid gland
created_by: tmeehan
creation_date: 2010-09-08T02:29:38Z

[Term]
id: CL:0002261
name: endothelial cell of viscerocranial mucosa
namespace: cell
alt_id: CL:1000446
def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256]
xref: FMA:70627
is_a: CL:0002076 ! endo-epithelial cell
created_by: tmeehan
creation_date: 2010-09-14T10:40:12Z

[Term]
id: CL:0002262
name: endothelial cell of sinusoid
namespace: cell
alt_id: CL:1000403
def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256]
xref: FMA:63134
is_a: CL:0000115 {is_inferred="true"} ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003909 ! sinusoid
relationship: part_of UBERON:0003909 ! sinusoid
created_by: tmeehan
creation_date: 2010-09-14T10:57:26Z

[Term]
id: CL:0002263
name: transitional cell of parathyroid gland
namespace: cell
def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911]
xref: FMA:69324
is_a: CL:0002260 ! epithelial cell of parathyroid gland
created_by: tmeehan
creation_date: 2010-09-08T02:33:50Z

[Term]
id: CL:0002264
name: type A cell of stomach
namespace: cell
def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm]
xref: FMA:83411
is_a: CL:0002067 ! type A enterocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0002067 ! type A enterocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
created_by: tmeehan
creation_date: 2010-09-10T10:54:42Z

[Term]
id: CL:0002265
name: type D cell of colon
namespace: cell
def: "A D cell located in the colon." [GOC:tfm]
xref: FMA:268744
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
created_by: tmeehan
creation_date: 2010-09-10T11:37:35Z

[Term]
id: CL:0002266
name: type D cell of small intestine
namespace: cell
def: "A type D cell of the small intestine." [GOC:tfm]
xref: FMA:268736
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine
created_by: tmeehan
creation_date: 2010-09-10T01:34:22Z

[Term]
id: CL:0002267
name: type D cell of stomach
namespace: cell
def: "A type D cell found in the stomach." [GOC:tfm]
xref: FMA:83410
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
created_by: tmeehan
creation_date: 2010-09-10T01:36:03Z

[Term]
id: CL:0002268
name: P/D1 enteroendocrine cell
namespace: cell
def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415]
xref: FMA:63207
xref: FMA:63418
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell
created_by: tmeehan
creation_date: 2010-09-10T01:47:45Z

[Term]
id: CL:0002269
name: vasoactive intestinal peptide secreting cell
namespace: cell
def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T01:52:20Z

[Term]
id: CL:0002270
name: type EC2 enteroendocrine cell
namespace: cell
def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415]
synonym: "Mo enteroendocrine cell" BROAD []
xref: FMA:62941
is_a: CL:0000577 ! type EC enteroendocrine cell
is_a: CL:0002272 ! motilin secreting cell
created_by: tmeehan
creation_date: 2010-09-10T02:13:47Z

[Term]
id: CL:0002271
name: type EC1 enteroendocrine cell
namespace: cell
def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651]
xref: FMA:62940
is_a: CL:0000505 ! substance P secreting cell
is_a: CL:0000577 ! type EC enteroendocrine cell
created_by: tmeehan
creation_date: 2010-09-10T02:13:49Z

[Term]
id: CL:0002272
name: motilin secreting cell
namespace: cell
def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D06.472.317.525]
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T02:31:13Z

[Term]
id: CL:0002273
name: type ECL enteroendocrine cell
namespace: cell
def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415]
xref: FMA:63208
is_a: CL:0000577 ! type EC enteroendocrine cell
is_a: CL:0002274 ! histamine secreting cell
created_by: tmeehan
creation_date: 2010-09-10T02:35:17Z

[Term]
id: CL:0002274
name: histamine secreting cell
namespace: cell
def: "A cell type that secretes histamine." [GOC:tfm]
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001821 ! histamine secretion
relationship: capable_of GO:0001821 ! histamine secretion
created_by: tmeehan
creation_date: 2010-09-10T03:04:42Z

[Term]
id: CL:0002275
name: pancreatic PP cell
namespace: cell
def: "A PP cell located in the islets of the pancreas." [GOC:tfm]
comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell.
synonym: "pancreatic polypeptide-secreting cell" EXACT []
synonym: "PP cell of pancreatic islet" EXACT []
synonym: "PP-cell of pancreatic islet" EXACT []
xref: BTO:0000805
xref: FMA:70588
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000696 ! PP cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: part_of UBERON:0001264 ! pancreas
created_by: tmeehan
creation_date: 2010-09-10T03:30:31Z

[Term]
id: CL:0002276
name: obsolete PP cell of pancreatic acinus
namespace: cell
def: "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [GOC:tfm]
synonym: "type F cell of pancreatic acinus" EXACT []
xref: FMA:85400
is_obsolete: true
created_by: tmeehan
creation_date: 2010-09-10T03:30:33Z

[Term]
id: CL:0002277
name: type I enteroendocrine cell
namespace: cell
def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm]
synonym: "CCK cell" EXACT []
xref: FMA:62937
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T03:44:36Z

[Term]
id: CL:0002278
name: GIP cell
namespace: cell
def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm]
synonym: "type K enteroendocrine cell" EXACT []
xref: FMA:62942
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T03:51:47Z

[Term]
id: CL:0002279
name: type L enteroendocrine cell
namespace: cell
def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415]
xref: FMA:62944
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T03:59:09Z

[Term]
id: CL:0002280
name: type N enteroendocrine cell
namespace: cell
def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm]
synonym: "N cell" EXACT []
xref: FMA:62943
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-10T04:08:29Z

[Term]
id: CL:0002281
name: type S enteroendocrine cell
namespace: cell
def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415]
xref: FMA:62936
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000458 ! serotonin secreting cell
created_by: tmeehan
creation_date: 2010-09-10T04:44:46Z

[Term]
id: CL:0002282
name: type TG enteroendocrine cell
namespace: cell
def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499]
xref: FMA:63421
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000509 ! gastrin secreting cell
created_by: tmeehan
creation_date: 2010-09-13T09:48:34Z

[Term]
id: CL:0002283
name: ecto-epithelial cell of viscerocranial mucosa
namespace: cell
alt_id: CL:1000440
def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908]
xref: FMA:70581
is_a: CL:0002159 ! general ecto-epithelial cell
created_by: tmeehan
creation_date: 2010-09-14T11:04:02Z

[Term]
id: CL:0002284
name: type X enteroendocrine cell
namespace: cell
def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512]
synonym: "A-like" EXACT []
synonym: "X/A-like" EXACT []
xref: FMA:63209
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0005018 ! ghrelin secreting cell
created_by: tmeehan
creation_date: 2010-09-13T10:12:12Z

[Term]
id: CL:0002285
name: type III taste bud cell
namespace: cell
def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192]
synonym: "taste bud basal cell" BROAD []
synonym: "type 3 taste cell" EXACT []
xref: FMA:67940
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000209 ! taste receptor cell
created_by: tmeehan
creation_date: 2010-09-13T10:57:21Z

[Term]
id: CL:0002286
name: type II taste cell
namespace: cell
def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192]
synonym: "type 2 taste cell" EXACT []
xref: FMA:62381
is_a: CL:0000209 ! taste receptor cell
created_by: tmeehan
creation_date: 2010-09-13T10:57:26Z

[Term]
id: CL:0002287
name: type IV taste receptor cell
namespace: cell
def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192]
comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192.
synonym: "taste bud basal cell" BROAD []
synonym: "type 4 taste cell" EXACT []
xref: FMA:62380
is_a: CL:0000034 ! stem cell
is_a: CL:0000209 ! taste receptor cell
created_by: tmeehan
creation_date: 2010-09-13T10:57:29Z

[Term]
id: CL:0002288
name: type V taste receptor cell
namespace: cell
def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651]
xref: FMA:67941
is_a: CL:0000209 ! taste receptor cell
created_by: tmeehan
creation_date: 2010-09-13T10:57:31Z

[Term]
id: CL:0002289
name: type I taste bud cell
namespace: cell
def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192]
synonym: "dark tongue cell" EXACT []
synonym: "type I taste cell" EXACT []
synonym: "type taste 1 cell" EXACT []
xref: FMA:62356
is_a: CL:0000209 ! taste receptor cell
is_a: CL:0000703 ! sustentacular cell
created_by: tmeehan
creation_date: 2010-09-13T10:57:35Z

[Term]
id: CL:0002290
name: Y chromosome-bearing sperm cell
namespace: cell
def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743]
synonym: "Y bearing sperm" EXACT []
synonym: "Y-bearing sperm" EXACT []
xref: FMA:84058
is_a: CL:0000019 ! sperm
created_by: tmeehan
creation_date: 2010-09-13T11:35:24Z

[Term]
id: CL:0002291
name: X chromosome-bearing sperm cell
namespace: cell
def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743]
synonym: "X bearing sperm" EXACT []
synonym: "X-bearing sperm" EXACT []
xref: FMA:84057
is_a: CL:0000019 ! sperm
created_by: tmeehan
creation_date: 2010-09-13T11:35:26Z

[Term]
id: CL:0002292
name: type I cell of carotid body
namespace: cell
def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651]
synonym: "glomus cell" EXACT []
xref: FMA:84186
is_a: CL:0000710 ! neurecto-epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T01:40:21Z

[Term]
id: CL:0002293
name: epithelial cell of thymus
namespace: cell
alt_id: CL:1000459
def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm]
synonym: "epithelial cell of thymus gland" EXACT []
synonym: "epithelial reticular cell" EXACT []
synonym: "epithelial reticular cell of thymus" EXACT []
synonym: "thymic epithelial cell" EXACT []
xref: CALOHA:TS-1040
xref: FMA:72208
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus
created_by: tmeehan
creation_date: 2010-09-13T02:34:22Z

[Term]
id: CL:0002294
name: type-1 epithelial cell of thymus
namespace: cell
def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335]
synonym: "subcapsular thymic epithelial cell" EXACT []
xref: FMA:72209
is_a: CL:0002364 ! cortical thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:23Z

[Term]
id: CL:0002295
name: type-6 epithelial cell of thymus
namespace: cell
def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335]
synonym: "cystic thymic epithelial cells" EXACT []
synonym: "large medullary thymic epithelial cells" EXACT []
synonym: "large mTEC" EXACT []
xref: FMA:72214
is_a: CL:0002365 ! medullary thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:26Z

[Term]
id: CL:0002296
name: type-4 epithelial cell of thymus
namespace: cell
def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335]
synonym: "dark thymic epithelial cell" EXACT []
xref: FMA:72212
is_a: CL:0002364 ! cortical thymic epithelial cell
is_a: CL:0002365 ! medullary thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:45Z

[Term]
id: CL:0002297
name: type-3 epithelial cell of thymus
namespace: cell
def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335]
synonym: "intermediate thymic epithelial cell" EXACT []
xref: FMA:72211
is_a: CL:0002364 ! cortical thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:51Z

[Term]
id: CL:0002298
name: type-5 epithelial cell of thymus
namespace: cell
def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335]
synonym: "undifferentiated medullary thymic epithelial cell" EXACT []
synonym: "undifferentiated mTEC" EXACT []
synonym: "undifferentiated thymic epithelial cell" EXACT []
xref: FMA:72213
is_a: CL:0002365 ! medullary thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:54Z

[Term]
id: CL:0002299
name: type-2 epithelial cell of thymus
namespace: cell
def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335]
synonym: "pale thymic epithelial cell" EXACT []
xref: FMA:72210
is_a: CL:0002364 ! cortical thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T02:37:58Z

[Term]
id: CL:0002300
name: type-7 epithelial cell of thymus
namespace: cell
def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455]
synonym: "spindle shaped medullary thymic epithelial cell" EXACT []
synonym: "spindle shaped mTEC" EXACT []
is_a: CL:0002365 ! medullary thymic epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T03:23:25Z

[Term]
id: CL:0002301
name: type B synovial cell
namespace: cell
def: "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [GOC:tfm, ISBN:0517223651]
xref: FMA:66788
is_a: CL:0000214 ! synovial cell
created_by: tmeehan
creation_date: 2010-09-13T03:39:14Z

[Term]
id: CL:0002302
name: type A synovial cell
namespace: cell
def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651]
synonym: "type A synoviocyte" EXACT []
xref: FMA:66787
is_a: CL:0000214 ! synovial cell
created_by: tmeehan
creation_date: 2010-09-13T03:39:17Z

[Term]
id: CL:0002303
name: pigmented ciliary epithelial cell
namespace: cell
def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [PMID:15106942]
synonym: "PE" EXACT []
xref: FMA:70606
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000529 ! pigmented epithelial cell
is_a: CL:0005012 ! multi-ciliated epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T04:09:27Z

[Term]
id: CL:0002304
name: non-pigmented ciliary epithelial cell
namespace: cell
def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [GOC:tfm, PMID:15106942]
synonym: "NPE" EXACT []
xref: FMA:70607
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0005012 ! multi-ciliated epithelial cell
created_by: tmeehan
creation_date: 2010-09-13T04:09:31Z

[Term]
id: CL:0002305
name: epithelial cell of distal tubule
namespace: cell
def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651]
synonym: "kidney distal tubule epithelial cell" EXACT []
xref: FMA:62125
xref: FMA:70981
xref: KUPO:0001055
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004135 ! distal tubule
relationship: part_of UBERON:0004135 ! distal tubule

[Term]
id: CL:0002306
name: epithelial cell of proximal tubule
namespace: cell
def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3]
synonym: "kidney proximal tubule epithelial cell" EXACT []
xref: FMA:62125
xref: FMA:70973
xref: KUPO:0001044
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004134 ! proximal tubule
relationship: part_of UBERON:0004134 ! proximal tubule

[Term]
id: CL:0002307
name: brush border cell of the proximal tubule
namespace: cell
def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [GOC:tfm, ISBN:1-4160-2328-3]
is_a: CL:0002306 ! epithelial cell of proximal tubule
created_by: tmeehan
creation_date: 2010-09-14T11:29:20Z

[Term]
id: CL:0002308
name: epithelial cell of skin gland
namespace: cell
def: "An epithelial cell of a skin gland." [GOC:tfm]
synonym: "epithelial cell of gland of skin" EXACT []
xref: FMA:70657
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002419 ! skin gland
relationship: part_of UBERON:0002419 ! skin gland
created_by: tmeehan
creation_date: 2010-09-14T12:00:07Z

[Term]
id: CL:0002309
name: corticotroph
namespace: cell
def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651]
xref: BTO:0002509
xref: FMA:83098
is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
created_by: tmeehan
creation_date: 2010-09-14T02:08:23Z

[Term]
id: CL:0002310
name: mammosomatotroph
namespace: cell
def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [GOC:tfm]
xref: FMA:83097
is_a: CL:0000295 ! somatotropin secreting cell
is_a: CL:0000439 ! prolactin secreting cell
is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis
created_by: tmeehan
creation_date: 2010-09-14T02:25:34Z

[Term]
id: CL:0002311
name: mammotroph
namespace: cell
def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl]
synonym: "epsilon-acidophil" EXACT []
synonym: "lactotrope" EXACT []
synonym: "lactotroph" EXACT []
synonym: "lactotropic cell" EXACT []
synonym: "mammotrope" EXACT []
synonym: "mammotrophic cell" EXACT []
synonym: "mammotropic cell" EXACT []
xref: FMA:83096
is_a: CL:0000439 ! prolactin secreting cell
is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis
created_by: tmeehan
creation_date: 2010-09-14T02:30:57Z

[Term]
id: CL:0002312
name: somatotroph
namespace: cell
def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl]
synonym: "somatotrope" EXACT []
synonym: "somatotropic cell" EXACT []
synonym: "somatrophic cell" EXACT []
xref: FMA:83095
is_a: CL:0000295 ! somatotropin secreting cell
is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis
created_by: tmeehan
creation_date: 2010-09-14T02:33:09Z

[Term]
id: CL:0002313
name: endocrine-paracrine cell of prostate gland
namespace: cell
def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm]
synonym: "glandular cell of prostate" EXACT []
synonym: "neuro-epithelial cell of prostate gland" EXACT []
xref: CALOHA:TS-1280
xref: FMA:74390
xref: FMA:86774
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: capable_of GO:0046879 ! hormone secretion
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: capable_of GO:0046879 ! hormone secretion
relationship: part_of UBERON:0002367 ! prostate gland
created_by: tmeehan
creation_date: 2010-09-14T03:01:58Z

[Term]
id: CL:0002314
name: external supporting cell of vestibular epithelium
namespace: cell
def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532]
xref: FMA:75809
is_a: CL:0002316 ! supporting cell of vestibular epithelium
created_by: tmeehan
creation_date: 2010-09-14T03:20:01Z

[Term]
id: CL:0002315
name: supporting cell of cochlea
namespace: cell
def: "An epithelial supporting cell located in the cochlea." [GOC:tfm]
xref: FMA:79796
is_a: CL:0001035 ! bone cell
is_a: CL:0005014 ! auditory epithelial support cell
intersection_of: CL:0005014 ! auditory epithelial support cell
intersection_of: part_of UBERON:0001844 ! cochlea
relationship: part_of UBERON:0001844 ! cochlea
created_by: tmeehan
creation_date: 2010-09-14T03:31:38Z

[Term]
id: CL:0002316
name: supporting cell of vestibular epithelium
namespace: cell
def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532]
xref: FMA:75607
is_a: CL:0005014 ! auditory epithelial support cell
intersection_of: CL:0005014 ! auditory epithelial support cell
intersection_of: part_of UBERON:0001862 ! vestibular labyrinth
relationship: part_of UBERON:0001862 ! vestibular labyrinth
created_by: tmeehan
creation_date: 2010-09-14T03:31:44Z

[Term]
id: CL:0002317
name: external limiting cell of vestibular epithelium
namespace: cell
def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm]
xref: FMA:75808
is_a: CL:0002316 ! supporting cell of vestibular epithelium
created_by: tmeehan
creation_date: 2010-09-14T03:33:50Z

[Term]
id: CL:0002318
name: periperhal blood mesothelial cell
namespace: cell
def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528]
xref: FMA:86712
is_a: CL:0000081 ! blood cell
relationship: develops_from CL:0000077 ! mesothelial cell
created_by: tmeehan
creation_date: 2010-09-15T10:47:11Z

[Term]
id: CL:0002319
name: neural cell
namespace: cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
xref: CALOHA:TS-2040
xref: FMA:70333
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001016 ! nervous system
created_by: tmeehan
creation_date: 2010-09-15T01:34:57Z

[Term]
id: CL:0002320
name: connective tissue cell
namespace: cell
alt_id: CL:1000406
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
xref: CALOHA:TS-2096
xref: FMA:63875
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 {is_inferred="true"} ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0002384 ! connective tissue
created_by: tmeehan
creation_date: 2010-09-15T03:01:54Z

[Term]
id: CL:0002321
name: embryonic cell
namespace: cell
def: "A cell of the embryo." [FMA:0618947256]
xref: CALOHA:TS-0263
xref: FMA:82840
xref: FMA:82841
xref: WBbt:0007028
is_a: CL:0000548 ! animal cell
created_by: tmeehan
creation_date: 2010-09-15T03:39:21Z

[Term]
id: CL:0002322
name: embryonic stem cell
namespace: cell
def: "A stem cell of embryonic origin." [GOC:dsd, GOC:tfm, ISBN:068340007X, PMID:18179856]
comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive.
synonym: "ESC" EXACT []
xref: BTO:0001086
xref: CALOHA:TS-0263
xref: FMA:82841
is_a: CL:0000034 ! stem cell
is_a: CL:0002321 ! embryonic cell
created_by: tmeehan
creation_date: 2010-09-15T03:44:35Z

[Term]
id: CL:0002323
name: amniocyte
namespace: cell
def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847]
xref: BTO:0000066
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: located_in UBERON:0000173 ! amniotic fluid
relationship: located_in UBERON:0000173 ! amniotic fluid
created_by: tmeehan
creation_date: 2010-09-20T10:13:37Z

[Term]
id: CL:0002324
name: myoepithelial cell of mammary gland
namespace: cell
def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771]
is_a: CL:1000416 ! myoepithelial cell of lactiferous gland
created_by: tmeehan
creation_date: 2010-09-20T11:42:14Z

[Term]
id: CL:0002325
name: mammary alveolar cell
namespace: cell
alt_id: CL:0002230
alt_id: CL:1000476
def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771]
synonym: "epithelial cell of lactiferous gland" EXACT []
synonym: "luminal cell of alveolus of lactiferous gland" EXACT []
xref: FMA:74506
xref: FMA:79866
is_a: CL:0000314 ! milk secreting cell
is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell
is_a: CL:1001586 ! mammary gland glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0003214 ! mammary gland alveolus
relationship: part_of UBERON:0003214 ! mammary gland alveolus
created_by: tmeehan
creation_date: 2010-09-20T01:30:57Z

[Term]
id: CL:0002326
name: luminal epithelial cell of mammary gland
namespace: cell
def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771]
xref: FMA:73280
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
created_by: tmeehan
creation_date: 2010-09-20T01:37:53Z

[Term]
id: CL:0002327
name: mammary gland epithelial cell
namespace: cell
def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771]
synonym: "breast epithelial cell" EXACT []
synonym: "mammary epithelial cell" EXACT []
xref: BTO:0004300
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
created_by: tmeehan
creation_date: 2010-09-20T01:49:37Z

[Term]
id: CL:0002328
name: bronchial epithelial cell
namespace: cell
def: "An epithelial cell of the bronchus." [GOC:tfm]
xref: BTO:0002922
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002185 ! bronchus
created_by: tmeehan
creation_date: 2010-09-20T02:00:00Z

[Term]
id: CL:0002329
name: basal epithelial cell of tracheobronchial tree
namespace: cell
def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm]
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
created_by: tmeehan
creation_date: 2010-09-20T02:10:36Z

[Term]
id: CL:0002330
name: undifferentiated cell of bronchus epithelium
namespace: cell
def: "An undifferentiated columnar cell of the bronchus epithelium" [GOC:tfm, PMID:18757316]
is_a: CL:0002328 ! bronchial epithelial cell
created_by: tmeehan
creation_date: 2010-09-20T02:17:58Z

[Term]
id: CL:0002332
name: ciliated cell of the bronchus
namespace: cell
def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316]
is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus
created_by: tmeehan
creation_date: 2010-09-20T02:21:12Z

[Term]
id: CL:0002333
name: neural crest derived fat cell
namespace: cell
def: "A fat cell derived from a neural crest cell." [GOC:tfm, PMID:17507398]
is_a: CL:0000136 ! fat cell
intersection_of: CL:0000136 ! fat cell
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000005 ! fibroblast neural crest derived
relationship: develops_from CL:0000333 ! migratory neural crest cell
created_by: tmeehan
creation_date: 2010-09-20T02:25:25Z

[Term]
id: CL:0002334
name: preadipocyte
namespace: cell
def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119]
xref: BTO:0001107
is_a: CL:0000057 ! fibroblast
created_by: tmeehan
creation_date: 2010-09-20T02:31:53Z

[Term]
id: CL:0002335
name: brown preadipocyte
namespace: cell
def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589]
is_a: CL:0002334 ! preadipocyte
created_by: tmeehan
creation_date: 2010-09-20T02:38:38Z

[Term]
id: CL:0002336
name: buccal mucosa cell
namespace: cell
def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599]
is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa
created_by: tmeehan
creation_date: 2010-09-20T02:52:54Z

[Term]
id: CL:0002337
name: keratinocyte stem cell
namespace: cell
def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [PMID:15339667]
synonym: "bulge keratinocyte" EXACT []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000312 ! keratinocyte
created_by: tmeehan
creation_date: 2010-09-20T03:07:03Z

[Term]
id: CL:0002338
name: CD56-positive, CD161-positive immature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell
relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
created_by: tmeehan
creation_date: 2010-09-21T10:06:53Z

[Term]
id: CL:0002339
name: prostate stem cell
namespace: cell
def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377]
synonym: "CD133-positive prostate epithelial cell" EXACT []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
created_by: tmeehan
creation_date: 2010-09-20T03:21:06Z

[Term]
id: CL:0002340
name: luminal cell of prostate epithelium
namespace: cell
def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm]
is_a: CL:0002231 ! epithelial cell of prostate
created_by: tmeehan
creation_date: 2010-09-20T03:34:05Z

[Term]
id: CL:0002341
name: basal cell of prostate epithelium
namespace: cell
def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349]
is_a: CL:0002231 ! epithelial cell of prostate
created_by: tmeehan
creation_date: 2010-09-20T03:34:10Z

[Term]
id: CL:0002342
name: circulating endothelial cell
namespace: cell
def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886]
is_a: CL:0000115 ! endothelial cell
created_by: tmeehan
creation_date: 2010-09-20T03:49:58Z

[Term]
id: CL:0002343
name: decidual natural killer cell
namespace: cell
def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965]
synonym: "decidual NK cell" EXACT []
synonym: "dNK cell" EXACT []
is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
intersection_of: has_plasma_membrane_part PR:000009766 ! galectin-1
intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1
relationship: has_plasma_membrane_part PR:000009766 ! galectin-1
relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
created_by: tmeehan
creation_date: 2010-09-20T04:00:02Z

[Term]
id: CL:0002344
name: CD56-negative, CD161-positive immature natural killer cell
namespace: cell
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta
relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule
relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1
created_by: tmeehan
creation_date: 2010-09-20T04:33:11Z

[Term]
id: CL:0002345
name: CD27-low, CD11b-low immature natural killer cell
namespace: cell
def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422]
comment: Markers are associated with mouse cells.
synonym: "preNK.BM" BROAD []
is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule
intersection_of: has_plasma_membrane_part PR:000001008 ! integrin alpha-2
intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
intersection_of: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48
relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule
relationship: has_plasma_membrane_part PR:000001008 ! integrin alpha-2
relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
relationship: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48
created_by: tmeehan
creation_date: 2010-09-20T04:41:01Z

[Term]
id: CL:0002346
name: Dx5-negative, NK1.1-positive immature natural killer cell
namespace: cell
def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763]
is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2
relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2
created_by: tmeehan
creation_date: 2010-09-21T10:11:44Z

[Term]
id: CL:0002347
name: CD27-high, CD11b-high natural killer cell
namespace: cell
def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422]
is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0032609 ! interferon-gamma production
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
relationship: capable_of GO:0032609 ! interferon-gamma production
relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
created_by: tmeehan
creation_date: 2010-09-21T10:19:49Z

[Term]
id: CL:0002348
name: CD27-low, CD11b-high natural killer cell
namespace: cell
def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922]
is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule
relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule
created_by: tmeehan
creation_date: 2010-09-21T10:19:54Z

[Term]
id: CL:0002349
name: CD27-high, CD11b-low natural killer cell
namespace: cell
def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922]
is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell
relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
created_by: tmeehan
creation_date: 2010-09-21T10:20:00Z

[Term]
id: CL:0002350
name: endocardial cell
namespace: cell
alt_id: CL:1000475
def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458]
synonym: "endocardial endothelial cell" EXACT []
synonym: "endothelial cell of endocardium" EXACT [FMA:75621]
xref: FMA:75621
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002165 ! endocardium
relationship: part_of UBERON:0002165 ! endocardium
created_by: tmeehan
creation_date: 2010-09-21T04:33:05Z

[Term]
id: CL:0002351
name: progenitor cell of endocrine pancreas
namespace: cell
def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494]
synonym: "pancreatic endocrine progenitor" EXACT []
synonym: "pancreatic islet progenitor cell" EXACT []
is_a: CL:0000048 ! multi fate stem cell
created_by: tmeehan
creation_date: 2010-09-21T04:41:06Z

[Term]
id: CL:0002352
name: gestational hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6]
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
created_by: tmeehan
creation_date: 2010-09-22T09:05:13Z

[Term]
id: CL:0002353
name: fetal liver hematopoietic progenitor cell
namespace: cell
def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764]
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: has_plasma_membrane_part GO:0042611 ! MHC protein complex
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule
intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4
relationship: has_plasma_membrane_part GO:0042611 ! MHC protein complex
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule
relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4
relationship: part_of UBERON:0002107 ! liver
created_by: tmeehan
creation_date: 2010-09-22T09:08:32Z

[Term]
id: CL:0002354
name: yolk sac hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm]
synonym: "hemangioblast precursor" EXACT []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex
intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex
relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: part_of UBERON:0001040 ! yolk sac
created_by: tmeehan
creation_date: 2010-09-22T09:08:34Z

[Term]
id: CL:0002355
name: primitive red blood cell
namespace: cell
def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698]
synonym: "primitive erythroblast" EXACT []
synonym: "primitive erythrocyte" EXACT []
synonym: "primitive erythroid cell" EXACT []
is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: bearer_of PATO:0000586 ! increased size
intersection_of: has_part PR:000008467 ! hemoglobin subunit zeta
intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1
intersection_of: part_of UBERON:0000922 ! embryo
relationship: bearer_of PATO:0000586 ! increased size
relationship: develops_from CL:0002361 ! primitive erythroid progenitor
relationship: has_part PR:000008467 ! hemoglobin subunit zeta
relationship: has_part PR:000008857 ! hemoglobin subunit beta-1
relationship: part_of UBERON:0000922 ! embryo
created_by: tmeehan
creation_date: 2010-09-22T09:27:05Z

[Term]
id: CL:0002356
name: primitive reticulocyte
namespace: cell
def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698]
synonym: "megalocyte" EXACT []
is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: bearer_of PATO:0000586 ! increased size
intersection_of: develops_from CL:0002355 ! primitive red blood cell
relationship: bearer_of PATO:0000586 ! increased size
relationship: develops_from CL:0002355 ! primitive red blood cell
created_by: tmeehan
creation_date: 2010-09-22T09:35:16Z

[Term]
id: CL:0002357
name: fetal derived definitive erythrocyte
namespace: cell
def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698]
synonym: "macrocyte" EXACT []
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1
intersection_of: part_of UBERON:0000922 ! embryo
relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell
relationship: has_part PR:000008857 ! hemoglobin subunit beta-1
relationship: part_of UBERON:0000922 ! embryo
created_by: tmeehan
creation_date: 2010-09-22T09:38:32Z

[Term]
id: CL:0002358
name: pyrenocyte
namespace: cell
def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm]
is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: bearer_of PATO:0000587 ! decreased size
intersection_of: develops_from CL:0002355 ! primitive red blood cell
relationship: bearer_of PATO:0000587 ! decreased size
relationship: develops_from CL:0002355 ! primitive red blood cell
created_by: tmeehan
creation_date: 2010-09-22T10:02:37Z

[Term]
id: CL:0002359
name: placental hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: tmeehan
creation_date: 2010-09-22T10:30:02Z

[Term]
id: CL:0002360
name: AGM hematopoietic stem cell
namespace: cell
def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6]
is_a: CL:0002352 ! gestational hematopoietic stem cell
created_by: tmeehan
creation_date: 2010-09-22T10:31:49Z

[Term]
id: CL:0002361
name: primitive erythroid progenitor
namespace: cell
def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979]
synonym: "EryP-CFC" EXACT []
synonym: "inner blood island hemangioblast" EXACT []
is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
relationship: develops_from CL:0002418 ! hemangioblast
relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb
created_by: tmeehan
creation_date: 2010-09-22T10:47:28Z

[Term]
id: CL:0002362
name: granule cell precursor
namespace: cell
def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007]
is_a: CL:0000337 ! neuroblast (sensu Vertebrata)
created_by: tmeehan
creation_date: 2010-09-22T01:40:44Z

[Term]
id: CL:0002363
name: keratocyte
namespace: cell
def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5]
synonym: "corneal fibroblast" EXACT []
synonym: "corneal keratocyte" EXACT []
is_a: CL:0000005 ! fibroblast neural crest derived
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001777 ! substantia propria of cornea
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001777 ! substantia propria of cornea
created_by: tmeehan
creation_date: 2010-09-22T01:57:40Z

[Term]
id: CL:0002364
name: cortical thymic epithelial cell
namespace: cell
def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190]
synonym: "cTEC" EXACT []
xref: BTO:0004562
is_a: CL:0002293 ! epithelial cell of thymus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002123 ! cortex of thymus
relationship: part_of UBERON:0002123 ! cortex of thymus
created_by: tmeehan
creation_date: 2010-09-23T03:17:12Z

[Term]
id: CL:0002365
name: medullary thymic epithelial cell
namespace: cell
def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458]
synonym: "mTEC" EXACT []
xref: BTO:0004563
is_a: CL:0002293 ! epithelial cell of thymus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002124 ! medulla of thymus
relationship: part_of UBERON:0002124 ! medulla of thymus
created_by: tmeehan
creation_date: 2010-09-23T03:17:14Z

[Term]
id: CL:0002366
name: myometrial cell
namespace: cell
def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640]
synonym: "myometrium smooth muscle cell" EXACT []
xref: BTO:0004519
is_a: CL:0002601 ! uterine smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001296 ! myometrium
relationship: part_of UBERON:0001296 ! myometrium
created_by: tmeehan
creation_date: 2010-09-23T03:46:34Z

[Term]
id: CL:0002367
name: trabecular meshwork cell
namespace: cell
def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [GOC:tfm, PMID:14500801]
synonym: "trabeculocyte" EXACT []
is_a: CL:0000115 {is_inferred="true"} ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0005969 ! eye trabecular meshwork
relationship: part_of UBERON:0005969 ! eye trabecular meshwork
created_by: tmeehan
creation_date: 2010-09-23T04:18:50Z

[Term]
id: CL:0002368
name: respiratory epithelial cell
namespace: cell
def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm]
synonym: "airway epithelial cell" EXACT []
xref: BTO:0004533
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract
created_by: tmeehan
creation_date: 2010-09-23T04:38:49Z

[Term]
id: CL:0002369
name: fungal spore
namespace: cell
def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm]
is_a: CL:0000521 ! fungal cell
created_by: tmeehan
creation_date: 2010-10-01T09:02:42Z

[Term]
id: CL:0002370
name: respiratory goblet cell
namespace: cell
def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544]
synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863]
is_a: CL:0000160 ! goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
created_by: tmeehan
creation_date: 2010-09-23T04:42:27Z

[Term]
id: CL:0002371
name: somatic cell
namespace: cell
def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544]
subset: ubprop:upper_level
xref: BTO:0001268
xref: FMA:72300
xref: WBbt:0008378
is_a: CL:0000003 ! native cell
created_by: tmeehan
creation_date: 2010-09-24T09:44:42Z

[Term]
id: CL:0002372
name: myotube
namespace: cell
alt_id: CL:0000369
def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696]
synonym: "myotubule" EXACT []
synonym: "single cell sarcomere" EXACT []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
intersection_of: bearer_of PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0002478 ! transversely striated
relationship: has_part GO:0030017 ! sarcomere
created_by: tmeehan
creation_date: 2010-09-24T01:13:01Z

[Term]
id: CL:0002373
name: growth hormone releasing hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm]
synonym: "GHRH secreting cell" EXACT []
synonym: "somatocrinin secreting cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
created_by: tmeehan
creation_date: 2010-09-24T01:36:44Z

[Term]
id: CL:0002374
name: ear hair cell
namespace: cell
def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023]
synonym: "ear receptor cell" EXACT []
is_a: CL:0000855 ! sensory hair cell
created_by: tmeehan
creation_date: 2010-09-24T01:49:31Z

[Term]
id: CL:0002375
name: Schwann cell precursor
namespace: cell
def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm]
synonym: "Schwann cell precursor cell" EXACT []
is_a: CL:0000030 ! glioblast
relationship: develops_from CL:0000333 ! migratory neural crest cell
created_by: tmeehan
creation_date: 2010-09-24T02:06:10Z

[Term]
id: CL:0002376
name: non-myelinating Schwann cell
namespace: cell
def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544]
synonym: "Schwann cell" BROAD []
is_a: CL:0002573 ! Schwann cell
relationship: develops_from CL:0002377 ! immature Schwann cell
created_by: tmeehan
creation_date: 2010-09-24T02:10:26Z

[Term]
id: CL:0002377
name: immature Schwann cell
namespace: cell
def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544]
synonym: "Schwann cell" BROAD []
xref: ZFA:0001725
is_a: CL:0002573 ! Schwann cell
relationship: develops_from CL:0002375 ! Schwann cell precursor
created_by: tmeehan
creation_date: 2010-09-24T02:10:31Z

[Term]
id: CL:0002378
name: immature Vgamma2-positive fetal thymocyte
namespace: cell
def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "fetal Vgamma2+ thymocyte" BROAD []
is_a: CL:0002404 ! fetal thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:21:07Z

[Term]
id: CL:0002379
name: meningothelial cell
namespace: cell
def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590]
synonym: "arachnoid cap cell" EXACT []
xref: FMA:86588
is_a: CL:0000710 ! neurecto-epithelial cell
created_by: tmeehan
creation_date: 2010-09-28T02:23:46Z

[Term]
id: CL:0002380
name: oospore
namespace: cell
def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt]
xref: FAO:0000039
is_a: CL:0000605 ! fungal asexual spore
created_by: tmeehan
creation_date: 2010-10-01T09:22:45Z

[Term]
id: CL:0002381
name: uninucleate conidium
namespace: cell
def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000025
is_a: CL:0000599 ! conidium
created_by: tmeehan
creation_date: 2010-10-01T09:26:39Z

[Term]
id: CL:0002382
name: multinucleate conidium
namespace: cell
def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000033
is_a: CL:0000599 ! conidium
created_by: tmeehan
creation_date: 2010-10-01T09:31:28Z

[Term]
id: CL:0002383
name: conidium of conidiophore head
namespace: cell
def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt]
xref: FAO:0000033
is_a: CL:0002381 ! uninucleate conidium

[Term]
id: CL:0002384
name: uninucleate macroconidium
namespace: cell
def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000029
is_a: CL:0000606 ! macroconidium
is_a: CL:0002381 ! uninucleate conidium

[Term]
id: CL:0002385
name: blastoconidium
namespace: cell
def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt]
synonym: "blastospore" RELATED []
xref: BTO:0000127
xref: FAO:0000042
is_a: CL:0000606 ! macroconidium

[Term]
id: CL:0002386
name: multinucleate macroconidium
namespace: cell
def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000035
is_a: CL:0000606 ! macroconidium
is_a: CL:0002382 ! multinucleate conidium

[Term]
id: CL:0002387
name: arthroconidium
namespace: cell
def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt]
synonym: "arthrospore" RELATED []
xref: FAO:0000041
is_a: CL:0000606 ! macroconidium

[Term]
id: CL:0002388
name: multinucleate arthroconidium
namespace: cell
def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000037
is_a: CL:0002386 ! multinucleate macroconidium
is_a: CL:0002387 ! arthroconidium

[Term]
id: CL:0002389
name: uninucleate arthroconidium
namespace: cell
def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000031
is_a: CL:0002384 ! uninucleate macroconidium
is_a: CL:0002387 ! arthroconidium

[Term]
id: CL:0002390
name: uninucleate blastconidium
namespace: cell
def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000030
is_a: CL:0002384 ! uninucleate macroconidium
is_a: CL:0002385 ! blastoconidium

[Term]
id: CL:0002391
name: multinucleate blastoconidium
namespace: cell
def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt]
xref: FAO:0000036
is_a: CL:0002385 ! blastoconidium
is_a: CL:0002386 ! multinucleate macroconidium

[Term]
id: CL:0002392
name: obsolete plant spore
namespace: cell
def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017]
comment: replaced_by: PO:0025017
is_obsolete: true

[Term]
id: CL:0002393
name: intermediate monocyte
namespace: cell
def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168]
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: has_not_completed GO:0030224 ! monocyte differentiation
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: develops_from CL:0000860 ! classical monocyte
relationship: has_not_completed GO:0030224 ! monocyte differentiation
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
created_by: tmeehan
creation_date: 2010-10-04T10:52:03Z

[Term]
id: CL:0002394
name: CD141-positive myeloid dendritic cell
namespace: cell
def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:dsd, GOC:tfm, PMCID:PMC2882828, PMCID:PMC2882837, PMID:17332250, PMID:20628149]
comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs.
is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell
is_a: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: CL:0000782 ! myeloid dendritic cell
intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
intersection_of: capable_of GO:0032606 ! type I interferon production
intersection_of: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I
intersection_of: has_plasma_membrane_part PR:000002105 ! thrombomodulin
relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response
relationship: capable_of GO:0032606 ! type I interferon production
relationship: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I
relationship: has_plasma_membrane_part PR:000002105 ! thrombomodulin
created_by: tmeehan
creation_date: 2010-10-04T02:38:58Z

[Term]
id: CL:0002395
name: Gr1-high classical monocyte
namespace: cell
def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:8890901]
comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product.
is_a: CL:0000860 {is_inferred="true"} ! classical monocyte
is_a: CL:0001022 ! CD115-positive monocyte
intersection_of: CL:0000860 ! classical monocyte
intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1
relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin
created_by: tmeehan
creation_date: 2010-10-04T11:26:18Z

[Term]
id: CL:0002396
name: CD14-low, CD16-positive monocyte
namespace: cell
def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168]
comment: Markers are associated with human monocytes.
synonym: "non-classical monocyte, human" EXACT []
is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte
is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte
intersection_of: CL:0000875 ! non-classical monocyte
intersection_of: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte
relationship: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
created_by: tmeehan
creation_date: 2010-10-04T12:25:42Z

[Term]
id: CL:0002397
name: CD14-positive, CD16-positive monocyte
namespace: cell
def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+).
synonym: "CD16+ monocyte" EXACT [PMID:22343568]
is_a: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:0001054 ! CD14-positive monocyte
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2
created_by: tmeehan
creation_date: 2010-10-04T12:49:47Z

[Term]
id: CL:0002398
name: Gr1-positive, CD43-positive monocyte
namespace: cell
def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149]
is_a: CL:0001022 ! CD115-positive monocyte
is_a: CL:0002393 ! intermediate monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
relationship: develops_from CL:0002395 ! Gr1-high classical monocyte
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
created_by: tmeehan
creation_date: 2010-10-04T12:49:49Z

[Term]
id: CL:0002399
name: CD1c-positive myeloid dendritic cell
namespace: cell
def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [GOC:dsd, GOC:tfm, PMID:20204387, PMID:20628149]
comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha.
is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell
intersection_of: CL:0000782 ! myeloid dendritic cell
intersection_of: capable_of GO:0032637 ! interleukin-8 production
intersection_of: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c
relationship: capable_of GO:0032637 ! interleukin-8 production
relationship: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c
created_by: tmeehan
creation_date: 2010-10-04T02:39:01Z

[Term]
id: CL:0002400
name: Fraction B/C precursor B cell
namespace: cell
def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: has_plasma_membrane_part PR:000001879 ! leukosialin
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
created_by: tmeehan
creation_date: 2010-10-05T10:11:38Z

[Term]
id: CL:0002401
name: mature dendritic epithelial T cell precursor
namespace: cell
def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "mature DEC precursor" EXACT []
synonym: "mature DETC precursor" EXACT []
is_a: CL:0002404 ! fetal thymocyte
relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor
created_by: tmeehan
creation_date: 2010-10-07T02:05:46Z

[Term]
id: CL:0002402
name: Peyer's patch B cell
namespace: cell
def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Peyers patch B cell" EXACT []
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin
intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2
relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5
relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin
relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor
relationship: part_of UBERON:0001211 ! Peyer's patch
created_by: tmeehan
creation_date: 2010-10-05T11:18:03Z

[Term]
id: CL:0002403
name: mature Vgamma2-positive fetal thymocyte
namespace: cell
def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "fetal Vgamma2-positive" EXACT []
is_a: CL:0002404 ! fetal thymocyte
relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:24:36Z

[Term]
id: CL:0002404
name: fetal thymocyte
namespace: cell
def: "A thymocyte found in the fetal thymus." [GOC:tfm]
is_a: CL:0000893 ! thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:28:25Z

[Term]
id: CL:0002405
name: gamma-delta thymocyte
namespace: cell
def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, PMID:20725107]
synonym: "gammadelta thymocyte" EXACT []
synonym: "gd thymocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
created_by: tmeehan
creation_date: 2010-10-07T02:33:39Z

[Term]
id: CL:0002406
name: immature Vgamma2-positive thymocyte
namespace: cell
def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "Vgamma2-positive thymocyte" BROAD []
is_a: CL:0002405 ! gamma-delta thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:53:44Z

[Term]
id: CL:0002407
name: mature Vgamma2-positive thymocyte
namespace: cell
def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "Vgamma2-positive" EXACT []
is_a: CL:0002405 ! gamma-delta thymocyte
relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:53:48Z

[Term]
id: CL:0002408
name: immature Vgamma2-negative thymocyte
namespace: cell
def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "Vgamma2-negative thymocyte" BROAD []
is_a: CL:0002405 ! gamma-delta thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:59:05Z

[Term]
id: CL:0002409
name: mature Vgamma2-negative thymocyte
namespace: cell
def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments.
synonym: "Vgamma2-negative" EXACT []
is_a: CL:0002405 ! gamma-delta thymocyte
relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte
created_by: tmeehan
creation_date: 2010-10-07T02:59:08Z

[Term]
id: CL:0002410
name: pancreatic stellate cell
namespace: cell
def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [GOC:mah, GOC:tfm, PMID:17200706]
synonym: "pancreas stellate cell" EXACT []
synonym: "PaSC" EXACT []
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0001264 ! pancreas
created_by: tmeehan
creation_date: 2010-11-10T09:40:33Z

[Term]
id: CL:0002411
name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte
namespace: cell
def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT []
is_a: CL:0002405 ! gamma-delta thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:07:44Z

[Term]
id: CL:0002412
name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte
namespace: cell
def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Vg1.1+Vd6.3+ T cell" EXACT []
is_a: CL:0002405 ! gamma-delta thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:03:00Z

[Term]
id: CL:0002413
name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte
namespace: cell
def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org]
synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED []
is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:10:32Z

[Term]
id: CL:0002414
name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte
namespace: cell
def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED []
is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:10:35Z

[Term]
id: CL:0002415
name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte
namespace: cell
def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT []
is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:10:39Z

[Term]
id: CL:0002416
name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte
namespace: cell
def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT []
is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte
created_by: tmeehan
creation_date: 2010-10-07T03:10:41Z

[Term]
id: CL:0002417
name: primitive erythroid lineage cell
namespace: cell
def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm]
is_a: CL:0000764 ! erythroid lineage cell
created_by: tmeehan
creation_date: 2010-10-12T11:22:41Z

[Term]
id: CL:0002418
name: hemangioblast
namespace: cell
def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698]
is_a: CL:0000222 ! mesodermal cell
relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell
created_by: tmeehan
creation_date: 2010-10-12T12:21:16Z

[Term]
id: CL:0002419
name: mature T cell
namespace: cell
def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm]
synonym: "CD3e-positive T cell" EXACT []
synonym: "CD3epsilon T cell" RELATED []
synonym: "mature T-cell" EXACT []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_completed GO:0045058 ! T cell selection
intersection_of: has_plasma_membrane_part GO:0042101 ! T cell receptor complex
relationship: has_completed GO:0045058 ! T cell selection
relationship: has_plasma_membrane_part GO:0042101 ! T cell receptor complex
created_by: tmeehan
creation_date: 2010-10-12T01:56:15Z

[Term]
id: CL:0002420
name: immature T cell
namespace: cell
def: "A T cell that has not completed T cell selection." [GOC:tfm]
synonym: "immature T-cell" EXACT []
xref: BTO:0001372
xref: CALOHA:TS-1042
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: has_not_completed GO:0045058 ! T cell selection
relationship: has_not_completed GO:0045058 ! T cell selection
created_by: tmeehan
creation_date: 2010-10-12T01:56:17Z

[Term]
id: CL:0002421
name: nucleated reticulocyte
namespace: cell
def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052]
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000558 ! reticulocyte
intersection_of: has_part GO:0005634 ! nucleus
relationship: has_part GO:0005634 ! nucleus
created_by: tmeehan
creation_date: 2010-10-15T09:24:05Z

[Term]
id: CL:0002422
name: enucleated reticulocyte
namespace: cell
def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464]
xref: CALOHA:TS-0864
xref: FMA:66785
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
intersection_of: CL:0000558 ! reticulocyte
intersection_of: bearer_of PATO:0001405 ! anucleate
intersection_of: has_part GO:0005840 ! ribosome
relationship: bearer_of PATO:0001405 ! anucleate
relationship: has_part GO:0005840 ! ribosome
created_by: tmeehan
creation_date: 2010-10-15T09:24:08Z

[Term]
id: CL:0002423
name: DN2a thymocyte
namespace: cell
def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614]
comment: Observed in mice.
is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte
intersection_of: CL:0000806 ! DN2 thymocyte
intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
created_by: tmeehan
creation_date: 2010-10-21T10:12:05Z

[Term]
id: CL:0002424
name: DN2b thymocyte
namespace: cell
def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614]
comment: Observed in mice.
is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte
intersection_of: CL:0000806 ! DN2 thymocyte
intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
relationship: develops_from CL:0002423 ! DN2a thymocyte
relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor
created_by: tmeehan
creation_date: 2010-10-21T10:12:08Z

[Term]
id: CL:0002425
name: early T lineage precursor
namespace: cell
def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251]
comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative.
synonym: "ETP" EXACT []
synonym: "preT.ETP.Th" EXACT []
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule
intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule
relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha
created_by: tmeehan
creation_date: 2010-10-21T01:16:24Z

[Term]
id: CL:0002426
name: CD11b-positive, CD27-positive natural killer cell
namespace: cell
def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive.
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule
created_by: tmeehan
creation_date: 2010-10-25T03:07:59Z

[Term]
id: CL:0002427
name: resting double-positive thymocyte
namespace: cell
def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "T.DP.sm.Th" EXACT []
is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: bearer_of PATO:0000587 ! decreased size
relationship: bearer_of PATO:0000587 ! decreased size
created_by: tmeehan
creation_date: 2010-10-21T01:59:06Z

[Term]
id: CL:0002428
name: double-positive blast
namespace: cell
def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "activated double-positive thymocyte" EXACT []
synonym: "T.DPb.Th" EXACT []
is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: bearer_of PATO:0000586 ! increased size
intersection_of: participates_in GO:0008283 ! cell proliferation
relationship: bearer_of PATO:0000586 ! increased size
relationship: develops_from CL:0002427 ! resting double-positive thymocyte
relationship: participates_in GO:0008283 ! cell proliferation
created_by: tmeehan
creation_date: 2010-10-21T01:59:11Z

[Term]
id: CL:0002429
name: CD69-positive double-positive thymocyte
namespace: cell
def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "T.DP69+.Th" EXACT []
is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: participates_in GO:0043368 ! positive T cell selection
relationship: develops_from CL:0002428 ! double-positive blast
relationship: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: participates_in GO:0043368 ! positive T cell selection
created_by: tmeehan
creation_date: 2010-10-21T02:11:52Z

[Term]
id: CL:0002430
name: CD4-intermediate, CD8-positive double-positive thymocyte
namespace: cell
def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "T.4int8+.Th" EXACT []
is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: participates_in GO:0043368 ! positive T cell selection
relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: participates_in GO:0043368 ! positive T cell selection
created_by: tmeehan
creation_date: 2010-10-21T02:29:19Z

[Term]
id: CL:0002431
name: CD4-positive, CD8-intermediate double-positive thymocyte
namespace: cell
def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "T.4int8+.th" EXACT []
is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte
intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
intersection_of: participates_in GO:0043368 ! positive T cell selection
relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: participates_in GO:0043368 ! positive T cell selection
created_by: tmeehan
creation_date: 2010-10-21T02:29:23Z

[Term]
id: CL:0002432
name: CD24-positive, CD4 single-positive thymocyte
namespace: cell
def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: Described in the immgene database as being CD24-intermediate.
synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT []
synonym: "T.4SP24int.Th" EXACT []
is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte
intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
created_by: tmeehan
creation_date: 2010-10-21T02:43:52Z

[Term]
id: CL:0002433
name: CD69-positive, CD4-positive single-positive thymocyte
namespace: cell
def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "intermediate CD4-single-positive" EXACT []
synonym: "T.4SP69+.Th" EXACT []
is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte
intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
created_by: tmeehan
creation_date: 2010-10-21T02:46:02Z

[Term]
id: CL:0002434
name: CD24-positive, CD8 single-positive thymocyte
namespace: cell
def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
comment: Described in the immgene database as being CD24-intermediate.
synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT []
synonym: "T.8SP24int.Th" EXACT []
is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte
intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24
created_by: tmeehan
creation_date: 2010-10-21T02:59:10Z

[Term]
id: CL:0002435
name: CD69-positive, CD8-positive single-positive thymocyte
namespace: cell
def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "intermediate CD8-single-positive" EXACT []
synonym: "T.8SP69+.Th" EXACT []
is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte
intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule
relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule
created_by: tmeehan
creation_date: 2010-10-21T02:59:14Z

[Term]
id: CL:0002436
name: mature CD4 single-positive thymocyte
namespace: cell
def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "T.4SP24-.Th" RELATED []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
created_by: tmeehan
creation_date: 2010-10-21T03:31:19Z

[Term]
id: CL:0002437
name: mature CD8 single-positive thymocyte
namespace: cell
def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http:www.immgen.org/index_content.html]
synonym: "T.8SP24-.Th" EXACT []
is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell
intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell
intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte
relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex
relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24
created_by: tmeehan
creation_date: 2010-10-21T03:51:50Z

[Term]
id: CL:0002438
name: NK1.1-positive natural killer cell
namespace: cell
def: "A mature NK cell that is NK1.1-positive." [GOC:tfm]
comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice.
synonym: "NK.sp" EXACT []
synonym: "NK1.1-positive NK cell" EXACT []
is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C
created_by: tmeehan
creation_date: 2010-10-25T03:18:04Z

[Term]
id: CL:0002439
name: NKGA2-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.G2A+.SP" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein
relationship: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein
created_by: tmeehan
creation_date: 2010-10-25T03:31:09Z

[Term]
id: CL:0002440
name: Ly49D-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.49D+.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4
relationship: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4
created_by: tmeehan
creation_date: 2010-10-25T03:36:19Z

[Term]
id: CL:0002441
name: CD94-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.94+.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
created_by: tmeehan
creation_date: 2010-10-25T03:36:28Z

[Term]
id: CL:0002442
name: CD94-negative, Ly49CI-negative natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "CD94- Ly49I-negative NK cell" EXACT []
synonym: "NK.49Cl-94-.Sp" EXACT []
is_a: CL:0002446 ! Ly49CI-negative natural killer cell
is_a: CL:0002447 ! CD94-negative natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
created_by: tmeehan
creation_date: 2010-10-25T03:56:21Z

[Term]
id: CL:0002443
name: Ly49CI-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Ly49I-positive NK cell" EXACT []
synonym: "NK.49Cl+.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
created_by: tmeehan
creation_date: 2010-10-25T03:36:38Z

[Term]
id: CL:0002444
name: Ly49H-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "LyH49H-positive" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8
relationship: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8
created_by: tmeehan
creation_date: 2010-10-25T03:36:43Z

[Term]
id: CL:0002445
name: Ly49D-negative natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.49D-.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4
relationship: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4
created_by: tmeehan
creation_date: 2010-10-25T03:39:02Z

[Term]
id: CL:0002446
name: Ly49CI-negative natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Ly49I-negative NK cell" EXACT []
synonym: "NK.49Cl-.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
created_by: tmeehan
creation_date: 2010-10-25T03:52:04Z

[Term]
id: CL:0002447
name: CD94-negative natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.94-.Sp" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
created_by: tmeehan
creation_date: 2010-10-25T03:54:18Z

[Term]
id: CL:0002448
name: Ly49H-negative natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "LyH49H-negative" EXACT []
is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8
relationship: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8
created_by: tmeehan
creation_date: 2010-10-25T03:42:42Z

[Term]
id: CL:0002449
name: CD94-positive Ly49CI-positive natural killer cell
namespace: cell
def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "NK.49Cl+94+.Sp" EXACT []
is_a: CL:0002441 ! CD94-positive natural killer cell
is_a: CL:0002443 ! Ly49CI-positive natural killer cell
intersection_of: CL:0002438 ! NK1.1-positive natural killer cell
intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1
relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3
created_by: tmeehan
creation_date: 2010-10-25T03:56:27Z

[Term]
id: CL:0002450
name: tether cell
namespace: cell
def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [GOC:cvs, GOC:tfm, PMID:9398434]
is_a: CL:0002374 ! ear hair cell
created_by: tmeehan
creation_date: 2010-11-10T01:41:00Z

[Term]
id: CL:0002451
name: mammary stem cell
namespace: cell
def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [GOC:hjd, GOC:tfm, PMID:15987436, PMID:16397499, PMID:17851544]
is_a: CL:0000048 ! multi fate stem cell
created_by: tmeehan
creation_date: 2010-11-10T01:46:51Z

[Term]
id: CL:0002453
name: oligodendrocyte precursor cell
namespace: cell
def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:20142420]
is_a: CL:0000123 {is_inferred="true"} ! neuron associated cell (sensu Vertebrata)
intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata)
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)
relationship: part_of UBERON:0001017 ! central nervous system
created_by: tmeehan
creation_date: 2010-11-10T02:51:34Z

[Term]
id: CL:0002454
name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
namespace: cell
def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.8-4-11b+" EXACT []
synonym: "spleen double-negative dendritic cell" EXACT []
is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell
intersection_of: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2010-11-22T01:10:28Z

[Term]
id: CL:0002455
name: CD8_alpha-negative plasmactyoid dendritic cell
namespace: cell
def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.pDC.8-" EXACT []
is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2010-11-22T01:27:37Z

[Term]
id: CL:0002456
name: CD8_alpha-positive plasmactyoid dendritic cell
namespace: cell
def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.pDC.8+" EXACT []
is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell
intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2010-11-22T01:23:07Z

[Term]
id: CL:0002457
name: epidermal Langerhans cell
namespace: cell
def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000453 ! Langerhans cell
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: located_in UBERON:0001003 ! skin epidermis
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: located_in UBERON:0001003 ! skin epidermis
created_by: tmeehan
creation_date: 2010-11-22T03:57:57Z

[Term]
id: CL:0002458
name: langerin-positive dermal dendritic cell
namespace: cell
def: "A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
is_a: CL:0002461 ! CD103-positive dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
created_by: tmeehan
creation_date: 2010-11-22T04:06:22Z

[Term]
id: CL:0002459
name: langerin-negative dermal dendritic cell
namespace: cell
def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell
relationship: lacks_plasma_membrane_part CL:0002507 ! langerin-positive lymph node dendritic cell
relationship: lacks_plasma_membrane_part CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell
relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
created_by: tmeehan
creation_date: 2010-11-22T04:09:44Z

[Term]
id: CL:0002460
name: CD8alpha-negative thymic conventional dendritic cell
namespace: cell
def: "A conventional thymic dendritic cell that is CD8alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629]
synonym: "DC.8-.Th" EXACT []
is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2010-11-23T10:58:53Z

[Term]
id: CL:0002461
name: CD103-positive dendritic cell
namespace: cell
def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
created_by: tmeehan
creation_date: 2010-11-23T01:32:43Z

[Term]
id: CL:0002462
name: adipose dendritic cell
namespace: cell
def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: develops_from CL:0002010 ! pre-conventional dendritic cell
relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: part_of UBERON:0001013 ! adipose tissue
created_by: tmeehan
creation_date: 2010-11-23T01:38:21Z

[Term]
id: CL:0002463
name: SIRPa-positive adipose dendritic cell
namespace: cell
def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.SIRPa+.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
created_by: tmeehan
creation_date: 2010-11-23T01:40:44Z

[Term]
id: CL:0002464
name: SIRPa-negative adipose dendritic cell
namespace: cell
def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.SIRPa-.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
relationship: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
created_by: tmeehan
creation_date: 2010-11-23T01:40:46Z

[Term]
id: CL:0002465
name: CD11b-positive dendritic cell
namespace: cell
def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
created_by: tmeehan
creation_date: 2010-11-23T01:50:05Z

[Term]
id: CL:0002466
name: small intestine serosal dendritic cell
namespace: cell
def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.11cloSer.SI" EXACT []
is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell
intersection_of: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
created_by: tmeehan
creation_date: 2010-11-23T02:00:21Z

[Term]
id: CL:0002467
name: Gr1-high myeloid suppressor cell
namespace: cell
def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MDS.Gr1hi" EXACT []
is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
created_by: tmeehan
creation_date: 2010-11-23T02:15:12Z

[Term]
id: CL:0002468
name: Gr1-low myeloid suppressor cell
namespace: cell
def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MDS.Gr1lo" EXACT []
is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
created_by: tmeehan
creation_date: 2010-11-23T02:19:43Z

[Term]
id: CL:0002469
name: MHC-II-negative classical monocyte
namespace: cell
def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6C+II-" EXACT []
is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T03:27:12Z

[Term]
id: CL:0002470
name: MHC-II-positive classical monocyte
namespace: cell
def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6c+II" EXACT []
is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T03:30:21Z

[Term]
id: CL:0002471
name: MHC-II-negative non-classical monocyte
namespace: cell
def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6C-II-" EXACT []
is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T03:38:15Z

[Term]
id: CL:0002472
name: MHC-II-low non-classical monocyte
namespace: cell
def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6C-IIint" EXACT []
is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T03:47:53Z

[Term]
id: CL:0002473
name: MHC-II-high non-classical monocyte
namespace: cell
def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6C-II+" EXACT []
is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte
intersection_of: CL:0002058 ! Gr1-low non-classical monocyte
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T03:47:55Z

[Term]
id: CL:0002474
name: lymphoid MHC-II-negative classical monocyte
namespace: cell
def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002469 {is_inferred="true"} ! MHC-II-negative classical monocyte
intersection_of: CL:0002469 ! MHC-II-negative classical monocyte
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
created_by: tmeehan
creation_date: 2010-11-23T04:00:52Z

[Term]
id: CL:0002475
name: lymphoid MHC-II-negative non-classical monocyte
namespace: cell
def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002469 ! MHC-II-negative classical monocyte
is_a: CL:0002471 ! MHC-II-negative non-classical monocyte
intersection_of: CL:0002469 ! MHC-II-negative classical monocyte
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
created_by: tmeehan
creation_date: 2010-11-23T04:09:09Z

[Term]
id: CL:0002476
name: bone marrow macrophage
namespace: cell
def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MF.BM" RELATED []
xref: BTO:0004732
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor
relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2
relationship: part_of UBERON:0002371 ! bone marrow
created_by: tmeehan
creation_date: 2010-11-23T04:19:25Z

[Term]
id: CL:0002477
name: adipose macrophage
namespace: cell
def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm]
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
created_by: tmeehan
creation_date: 2010-11-23T04:31:28Z

[Term]
id: CL:0002478
name: F4/80-negative adipose macrophage
namespace: cell
def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MF.Autofl.Ad" EXACT []
is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
created_by: tmeehan
creation_date: 2010-11-23T04:40:50Z

[Term]
id: CL:0002479
name: F4/80-positive adipose macrophage
namespace: cell
def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MF.F480+.Ad" EXACT []
is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1
relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex
created_by: tmeehan
creation_date: 2010-11-23T04:35:53Z

[Term]
id: CL:0002480
name: nasal mucosa goblet cell
namespace: cell
def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm]
xref: MP:0002262
is_a: CL:0002370 ! respiratory goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0005384 ! nasal cavity epithelium
created_by: tmeehan
creation_date: 2010-12-03T03:03:02Z

[Term]
id: CL:0002481
name: peritubular myoid cell
namespace: cell
def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420]
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis
created_by: tmeehan
creation_date: 2010-12-03T03:11:48Z

[Term]
id: CL:0002482
name: dermal melanocyte
namespace: cell
def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386]
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
created_by: tmeehan
creation_date: 2010-12-03T03:17:05Z

[Term]
id: CL:0002483
name: hair follicle melanocyte
namespace: cell
def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381]
is_a: CL:0002559 ! hair follicle cell
is_a: CL:2000000 ! epidermal melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0002073 ! hair follicle
created_by: tmeehan
creation_date: 2010-12-03T03:17:09Z

[Term]
id: CL:0002484
name: epithelial melanocyte
namespace: cell
def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388]
comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. 
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0000483 ! epithelium
relationship: part_of UBERON:0000483 ! epithelium
created_by: tmeehan
creation_date: 2010-12-03T03:17:14Z

[Term]
id: CL:0002485
name: retinal melanocyte
namespace: cell
def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190]
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina
created_by: tmeehan
creation_date: 2010-12-03T03:25:32Z

[Term]
id: CL:0002486
name: strial intermediate cell
namespace: cell
def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048]
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002484 ! epithelial melanocyte
is_a: CL:0002491 ! auditory epithelial cell
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct
relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct
created_by: tmeehan
creation_date: 2010-12-03T03:29:15Z

[Term]
id: CL:0002487
name: cutaneous/subcutaneous mechanoreceptor cell
namespace: cell
def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973]
is_a: CL:0000199 ! mechanoreceptor cell
created_by: tmeehan
creation_date: 2010-12-06T02:53:30Z

[Term]
id: CL:0002488
name: trophoblast giant cell
namespace: cell
def: "A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834]
synonym: "giant trophoblast cell" EXACT []
is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: bearer_of PATO:0000586 ! increased size
intersection_of: capable_of GO:0001974 ! blood vessel remodeling
relationship: bearer_of PATO:0000586 ! increased size
relationship: capable_of GO:0001974 ! blood vessel remodeling
created_by: tmeehan
creation_date: 2010-12-06T02:55:24Z

[Term]
id: CL:0002489
name: double negative thymocyte
namespace: cell
def: "A thymocyte that lacks expression of CD4 and CD8." [GOC:tfm, MP:0002407]
synonym: "double negative T cell" BROAD []
is_a: CL:0000893 {is_inferred="true"} ! thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8
created_by: tmeehan
creation_date: 2010-12-06T03:03:38Z

[Term]
id: CL:0002490
name: organ of Corti supporting cell
namespace: cell
def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300]
is_a: CL:0002315 ! supporting cell of cochlea
intersection_of: CL:0005014 ! auditory epithelial support cell
intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea
relationship: part_of UBERON:0002227 ! spiral organ of cochlea
created_by: tmeehan
creation_date: 2010-12-06T03:09:01Z

[Term]
id: CL:0002491
name: auditory epithelial cell
namespace: cell
def: "A specialized cell involved in auditory sensory perception." [GOC:tfm]
is_a: CL:0000098 ! sensory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
created_by: tmeehan
creation_date: 2010-12-06T03:18:43Z

[Term]
id: CL:0002492
name: strial marginal cell
namespace: cell
def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366]
is_a: CL:0002491 ! auditory epithelial cell
created_by: tmeehan
creation_date: 2010-12-06T03:20:41Z

[Term]
id: CL:0002493
name: strial basal cell
namespace: cell
def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365]
comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863]
is_a: CL:0002491 ! auditory epithelial cell
relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct
created_by: tmeehan
creation_date: 2010-12-06T03:26:53Z

[Term]
id: CL:0002494
name: cardiocyte
namespace: cell
def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm]
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
synonym: "heart cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:83808
xref: FMA:84791
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 {is_inferred="true"} ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
relationship: part_of UBERON:0007100 ! primary circulatory organ
created_by: tmeehan
creation_date: 2010-12-07T09:37:22Z

[Term]
id: CL:0002495
name: fetal cardiomyocyte
namespace: cell
def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788]
synonym: "embryonic cardiomyocyte" EXACT []
synonym: "neonatal cardiomyocyte" EXACT []
is_a: CL:0000746 ! cardiac muscle cell
created_by: tmeehan
creation_date: 2010-12-07T09:50:41Z

[Term]
id: CL:0002496
name: intraepithelial lymphocyte
namespace: cell
def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894]
synonym: "IEL" EXACT []
synonym: "intraepithelial T cell" EXACT []
synonym: "intraepithelial T-cell" EXACT []
is_a: CL:0002419 {is_inferred="true"} ! mature T cell
intersection_of: CL:0002419 ! mature T cell
intersection_of: capable_of GO:0002385 ! mucosal immune response
intersection_of: located_in UBERON:0001277 ! intestinal epithelium
relationship: capable_of GO:0002385 ! mucosal immune response
relationship: located_in UBERON:0001277 ! intestinal epithelium
created_by: tmeehan
creation_date: 2010-12-07T09:54:50Z

[Term]
id: CL:0002497
name: primary trophoblast giant cell
namespace: cell
def: "A trophoblast giant cell derived from the mural trophectoderm." [GOC:tfm, PMCID:PMC85124]
xref: EMAPA:16066
is_a: CL:0002488 ! trophoblast giant cell
created_by: tmeehan
creation_date: 2010-12-07T10:07:47Z

[Term]
id: CL:0002498
name: secondary trophoblast giant cell
namespace: cell
def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [GOC:tfm, PMCID:PMC85124]
is_a: CL:0002488 ! trophoblast giant cell
created_by: tmeehan
creation_date: 2010-12-07T10:07:52Z

[Term]
id: CL:0002499
name: spongiotrophoblast cell
namespace: cell
def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959]
is_a: CL:0000351 ! trophoblast cell
created_by: tmeehan
creation_date: 2010-12-07T12:56:56Z

[Term]
id: CL:0002500
name: P enteroendocrine cell
namespace: cell
def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [FMA:63418, GOC:tfm]
is_a: CL:0002268 ! P/D1 enteroendocrine cell
created_by: tmeehan
creation_date: 2010-12-07T03:42:06Z

[Term]
id: CL:0002501
name: type D1 enteroendocrine cell
namespace: cell
def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [FMA:63207, GOC:tfm]
xref: FMA:63207
is_a: CL:0002268 ! P/D1 enteroendocrine cell
created_by: tmeehan
creation_date: 2010-12-07T03:42:09Z

[Term]
id: CL:0002502
name: type M enteroendocrine cell
namespace: cell
def: "An enteroendocrine cell of the small intestine that secretes motilin." [GOC:tfm, PMID:15153415]
synonym: "Mo enteroendocrine cell" BROAD []
xref: FMA:63420
is_a: CL:0002272 ! motilin secreting cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001598 ! small intestine glandular cell
relationship: part_of UBERON:0002108 ! small intestine
created_by: tmeehan
creation_date: 2010-12-07T03:55:49Z

[Term]
id: CL:0002503
name: adventitial cell
namespace: cell
def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm]
xref: BTO:0002441
xref: FMA:84639
is_a: CL:0000630 ! supportive cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0005742 ! adventitia
relationship: part_of UBERON:0005742 ! adventitia
created_by: tmeehan
creation_date: 2010-12-07T04:03:56Z

[Term]
id: CL:0002504
name: enteric smooth muscle cell
namespace: cell
def: "A smooth muscle cell of the intestine." [GOC:tfm]
synonym: "intestinal smooth muscle cell" EXACT []
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
created_by: tmeehan
creation_date: 2011-01-17T03:39:38Z

[Term]
id: CL:0002505
name: liver CD103-negative dendritic cell
namespace: cell
def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [GOC:tfm, http:http\://www.immgen.org/index_content.html]
synonym: "DC.103-11b+.Lv" EXACT []
is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
intersection_of: located_in UBERON:0001281 ! hepatic sinusoid
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: located_in UBERON:0001281 ! hepatic sinusoid
created_by: tmeehan
creation_date: 2011-01-21T01:27:41Z

[Term]
id: CL:0002506
name: liver CD103-positive dendritic cell
namespace: cell
def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [GOC:tfm, http:http\://www.immgen.org/index_content.html]
synonym: "DC.103+11b-.Lv" EXACT []
is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
is_a: CL:0002461 ! CD103-positive dendritic cell
intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
intersection_of: located_in UBERON:0001281 ! hepatic sinusoid
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: located_in UBERON:0001281 ! hepatic sinusoid
created_by: tmeehan
creation_date: 2011-01-21T01:27:45Z

[Term]
id: CL:0002507
name: langerin-positive lymph node dendritic cell
namespace: cell
def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
created_by: tmeehan
creation_date: 2011-01-21T01:57:00Z

[Term]
id: CL:0002508
name: langerin-negative, CD103-negative lymph node dendritic cell
namespace: cell
def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K
relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex
relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule
relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K
created_by: tmeehan
creation_date: 2011-01-21T02:13:58Z

[Term]
id: CL:0002509
name: CD103-positive, langerin-positive lymph node dendritic cell
namespace: cell
def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
is_a: CL:0002461 ! CD103-positive dendritic cell
is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell
intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E
created_by: tmeehan
creation_date: 2011-01-21T02:07:54Z

[Term]
id: CL:0002510
name: CD103-negative, langerin-positive lymph node dendritic cell
namespace: cell
def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell
intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E
created_by: tmeehan
creation_date: 2011-01-21T02:11:14Z

[Term]
id: CL:0002511
name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell
namespace: cell
def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell
intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell
intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M
created_by: tmeehan
creation_date: 2011-01-21T02:22:15Z

[Term]
id: CL:0002512
name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell
namespace: cell
def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell
is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell
intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell
intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M
created_by: tmeehan
creation_date: 2011-01-21T02:16:21Z

[Term]
id: CL:0002513
name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell
namespace: cell
def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "tgd.vg5+.IEL" EXACT []
is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell
created_by: tmeehan
creation_date: 2011-01-24T10:22:18Z

[Term]
id: CL:0002514
name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell
namespace: cell
def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "tgd.vg5-.IEL" EXACT []
is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell
created_by: tmeehan
creation_date: 2011-01-24T10:25:44Z

[Term]
id: CL:0002515
name: interrenal norepinephrine type cell
namespace: cell
def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [GOC:MH, GOC:tfm, PMID:12668625]
synonym: "interrenal noradrenaline type cell" EXACT []
synonym: "type n interrenal cell" EXACT []
is_a: CL:0000459 ! noradrenergic cell
is_a: CL:0002516 ! interrenal chromaffin cell
created_by: tmeehan
creation_date: 2011-02-08T10:11:55Z

[Term]
id: CL:0002516
name: interrenal chromaffin cell
namespace: cell
def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [GOC:MH, GOC:tfm, PMID:12668625]
is_a: CL:0000166 ! chromaffin cell
created_by: tmeehan
creation_date: 2011-02-08T10:21:35Z

[Term]
id: CL:0002517
name: interrenal epinephrin secreting cell
namespace: cell
def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [GOC:MH, GOC:tfm, PMID:12668625]
synonym: "interrenal adrenaline secreting cell" RELATED []
synonym: "type a interrenal cell" EXACT []
is_a: CL:0000454 ! epinephrine secreting cell
is_a: CL:0002516 ! interrenal chromaffin cell
created_by: tmeehan
creation_date: 2011-02-08T10:27:05Z

[Term]
id: CL:0002518
name: kidney epithelial cell
namespace: cell
def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ]
xref: KUPO:0001019
is_a: CL:0000066 ! epithelial cell
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
created_by: tmeehan
creation_date: 2011-02-08T10:46:34Z

[Term]
id: CL:0002519
name: interrenal epithelial cell
namespace: cell
def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [GOC:mh, GOC:tfm, PMID:12668625]
is_a: CL:0002518 ! kidney epithelial cell
created_by: tmeehan
creation_date: 2011-02-08T11:03:32Z

[Term]
id: CL:0002520
name: nephrocyte
namespace: cell
def: "An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis." [GOC:tfm, PMID:19783135]
xref: BTO:0004597
xref: FMA:83807
is_a: CL:0002522 ! renal filtration cell
created_by: tmeehan
creation_date: 2011-02-08T01:34:56Z

[Term]
id: CL:0002521
name: subcutaneous fat cell
namespace: cell
def: "A fat cell that is part of subcutaneous adipose tissue." [GOC:tfm]
synonym: "subcutaneous adipocyte" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! fat cell
intersection_of: CL:0000136 ! fat cell
intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue
relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue
created_by: tmeehan
creation_date: 2011-02-21T02:51:22Z

[Term]
id: CL:0002522
name: renal filtration cell
namespace: cell
def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm]
is_a: CL:0000424 ! excretory cell
relationship: part_of UBERON:0001008 ! renal system
created_by: tmeehan
creation_date: 2011-02-08T01:37:59Z

[Term]
id: CL:0002523
name: mesonephric glomerular visceral epithelial cell
namespace: cell
def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros" [GOC:tfm]
is_a: CL:0000653 ! glomerular visceral epithelial cell
intersection_of: CL:0000653 ! glomerular visceral epithelial cell
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
created_by: tmeehan
creation_date: 2011-02-08T01:58:30Z

[Term]
id: CL:0002524
name: disseminated nephrocyte
namespace: cell
def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [GOC:tfm, PMID:19783135]
is_a: CL:0002520 ! nephrocyte
created_by: tmeehan
creation_date: 2011-02-08T02:07:33Z

[Term]
id: CL:0002525
name: metanephric glomerular visceral epithelial cell
namespace: cell
def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm]
is_a: CL:0000653 ! glomerular visceral epithelial cell
intersection_of: CL:0000653 ! glomerular visceral epithelial cell
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
created_by: tmeehan
creation_date: 2011-02-08T02:02:13Z

[Term]
id: CL:0002526
name: CD14-positive dermal dendritic cell
namespace: cell
def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [GOC:dsd, PMID:19236899, PMID:20309010]
comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis.
synonym: "CD14+ dermal DC" EXACT []
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: capable_of GO:0045191 ! regulation of isotype switching
intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule
intersection_of: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a
relationship: capable_of GO:0045191 ! regulation of isotype switching
relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule
relationship: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a

[Term]
id: CL:0002527
name: immature CD14-positive dermal dendritic cell
namespace: cell
def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd]
is_a: CL:0001009 ! immature dermal dendritic cell
is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell
intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0002528
name: mature CD14-positive dermal dendritic cell
namespace: cell
def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GOC:dsd]
is_a: CL:0001010 ! mature dermal dendritic cell
is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell
intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0002527 ! immature CD14-positive dermal dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0002529
name: CD1a-positive dermal dendritic cell
namespace: cell
def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [GOC:dsd, PMID:20309010]
comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse.
synonym: "CD1a+ dermal DC" EXACT []
is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell
intersection_of: CL:0001006 ! dermal dendritic cell
intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a
relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a

[Term]
id: CL:0002530
name: immature CD1a-positive dermal dendritic cell
namespace: cell
def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd]
is_a: CL:0001009 ! immature dermal dendritic cell
is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell
intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0002531
name: mature CD1a-positive dermal dendritic cell
namespace: cell
def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd]
is_a: CL:0001010 ! mature dermal dendritic cell
is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell
intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0002530 ! immature CD1a-positive dermal dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0002532
name: CD16-positive myeloid dendritic cell
namespace: cell
def: "A myeloid dendritic cell found in the blood that is CD16-positive." [GOC:dsd, PMID:17332250]
comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8).
synonym: "CD16+ mDC" EXACT []
synonym: "CD16-mDC" EXACT []
is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell
intersection_of: CL:0000782 ! myeloid dendritic cell
intersection_of: capable_of GO:0032640 ! tumor necrosis factor production
intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: capable_of GO:0032640 ! tumor necrosis factor production
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III

[Term]
id: CL:0002533
name: immature CD16-positive myeloid dendritic cell
namespace: cell
def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd]
is_a: CL:0000840 ! immature conventional dendritic cell
is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell
intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule

[Term]
id: CL:0002534
name: mature CD16-positive myeloid dendritic cell
namespace: cell
def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd]
is_a: CL:0000841 ! mature conventional dendritic cell
is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell
intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell
intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule
relationship: develops_from CL:0002533 ! immature CD16-positive myeloid dendritic cell
relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex
relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule
relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule
relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule

[Term]
id: CL:0002535
name: epithelial cell of cervix
namespace: cell
def: "An epithelial cell of the cervix." [GOC:tfm]
synonym: "cervical canal epithelial cell" EXACT [GOC:tfm]
synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "cervix epithelial cell" EXACT [GOC:tfm]
synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm]
synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm]
synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm]
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0004801 ! cervix epithelium
created_by: tmeehan
creation_date: 2011-02-24T08:20:08Z

[Term]
id: CL:0002536
name: epithelial cell of amnion
namespace: cell
def: "An epithelial cell that is part of the amnion." [GOC:tfm]
synonym: "amniotic epithelial cell" EXACT []
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000305 ! amnion
relationship: part_of UBERON:0000305 ! amnion
created_by: tmeehan
creation_date: 2011-02-28T12:38:01Z

[Term]
id: CL:0002537
name: amnion mesenchymal stem cell
namespace: cell
def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039]
synonym: "amniotic membrane stem cell" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0000305 ! amnion
relationship: part_of UBERON:0000305 ! amnion
created_by: tmeehan
creation_date: 2011-02-28T12:44:24Z

[Term]
id: CL:0002538
name: intrahepatic bile duct epithelial cell
namespace: cell
def: "An epithelial cell of the intrahepatic portion of the bile duct." [GOC:tfm]
is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
created_by: tmeehan
creation_date: 2011-02-28T01:20:20Z

[Term]
id: CL:0002539
name: aortic smooth muscle cell
namespace: cell
def: "A smooth muscle cell of the aorta." [GOC:tfm]
xref: BTO:0004577
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue
relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue
created_by: tmeehan
creation_date: 2011-02-28T01:42:12Z

[Term]
id: CL:0002540
name: mesenchymal stem cell of the bone marrow
namespace: cell
def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: tmeehan
creation_date: 2011-02-28T01:47:47Z

[Term]
id: CL:0002541
name: chorionic membrane mesenchymal stem cell
namespace: cell
def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003124 ! chorion
relationship: part_of UBERON:0003124 ! chorion
created_by: tmeehan
creation_date: 2011-02-28T03:04:35Z

[Term]
id: CL:0002543
name: vein endothelial cell
namespace: cell
alt_id: CL:1000393
def: "An endothelial cell that is part of the vein." [GOC:tfm]
synonym: "endothelial cell of vein" EXACT []
synonym: "venous endothelial cell" EXACT []
xref: FMA:62104
xref: KUPO:0001099
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein
created_by: tmeehan
creation_date: 2011-02-28T03:48:11Z

[Term]
id: CL:0002544
name: aortic endothelial cell
namespace: cell
def: "An arterial endothelial cell that is part of the aorta endothelium." [GOC:tfm]
xref: BTO:0003245
xref: CALOHA:TS-0047
is_a: CL:1000413 ! endothelial cell of artery
created_by: tmeehan
creation_date: 2011-02-28T03:54:42Z

[Term]
id: CL:0002545
name: thoracic aorta endothelial cell
namespace: cell
def: "An endothelial cell that is part of the thoracic endothelium." [GOC:tfm]
is_a: CL:0002544 {is_inferred="true"} ! aortic endothelial cell
intersection_of: CL:0002544 ! aortic endothelial cell
intersection_of: part_of UBERON:0001515 ! thoracic aorta
relationship: part_of UBERON:0001515 ! thoracic aorta
created_by: tmeehan
creation_date: 2011-02-28T03:59:09Z

[Term]
id: CL:0002546
name: embryonic blood vessel endothelial progenitor cell
namespace: cell
def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm]
comment: See CL:0002619.
is_a: CL:0000222 ! mesodermal cell
is_a: CL:0002371 ! somatic cell
created_by: tmeehan
creation_date: 2011-02-28T04:20:39Z

[Term]
id: CL:0002547
name: fibroblast of the aortic adventitia
namespace: cell
def: "A fibroblast of the aortic adventitia." [GOC:tfm]
is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery
intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery
intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia
relationship: part_of UBERON:0004664 ! aorta tunica adventitia
created_by: tmeehan
creation_date: 2011-02-28T04:43:41Z

[Term]
id: CL:0002548
name: fibroblast of cardiac tissue
namespace: cell
def: "A fibroblast that is part of the heart." [GOC:tfm]
synonym: "cardiac fibroblast" EXACT []
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002494 {is_inferred="true"} ! cardiocyte
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
created_by: tmeehan
creation_date: 2011-02-28T04:57:44Z

[Term]
id: CL:0002549
name: fibroblast of choroid plexus
namespace: cell
def: "A fibroblast that is part of the choroid plexus." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus
created_by: tmeehan
creation_date: 2011-02-28T05:01:39Z

[Term]
id: CL:0002550
name: fibroblast of the conjunctiva
namespace: cell
def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm]
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva
created_by: tmeehan
creation_date: 2011-02-28T05:03:44Z

[Term]
id: CL:0002551
name: fibroblast of dermis
namespace: cell
is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
created_by: tmeehan
creation_date: 2011-02-28T05:05:33Z

[Term]
id: CL:0002552
name: fibroblast of gingiva
namespace: cell
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001828 ! gingiva
relationship: part_of UBERON:0001828 ! gingiva
created_by: tmeehan
creation_date: 2011-02-28T05:09:12Z

[Term]
id: CL:0002553
name: fibroblast of lung
namespace: cell
def: "A fibroblast that is part of lung." [GOC:tfm]
xref: BTO:0000764
xref: CALOHA:TS-0575
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
created_by: tmeehan
creation_date: 2011-02-28T05:11:03Z

[Term]
id: CL:0002554
name: fibroblast of lymphatic vessel
namespace: cell
def: "A fibroblast of the lymphatic system." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: part_of UBERON:0001473 ! lymphatic vessel
created_by: tmeehan
creation_date: 2011-02-28T05:16:18Z

[Term]
id: CL:0002555
name: fibroblast of mammary gland
namespace: cell
def: "A fibroblast that is part of the mammary gland." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
created_by: tmeehan
creation_date: 2011-02-28T05:18:38Z

[Term]
id: CL:0002556
name: fibroblast of periodontium
namespace: cell
def: "A fibroblast of the periodontium." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001758 ! periodontium
relationship: part_of UBERON:0001758 ! periodontium
created_by: tmeehan
creation_date: 2011-02-28T05:19:48Z

[Term]
id: CL:0002557
name: fibroblast of pulmonary artery
namespace: cell
def: "A fibroblast of pulmonary artery." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
created_by: tmeehan
creation_date: 2011-02-28T05:22:27Z

[Term]
id: CL:0002558
name: fibroblast of villous mesenchyme
namespace: cell
def: "A fibroblast that is part of villous mesenchyme." [GOC:tfm]
is_a: CL:0000057 ! fibroblast
is_a: CL:0000349 ! extraembryonic cell
relationship: part_of UBERON:0001987 ! placenta
created_by: tmeehan
creation_date: 2011-02-28T05:24:28Z

[Term]
id: CL:0002559
name: hair follicle cell
namespace: cell
def: "An animal cell that is part of a hair follicle." [GOC:tfm]
is_a: CL:0002371 {is_inferred="true"} ! somatic cell
intersection_of: CL:0002371 ! somatic cell
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0002073 ! hair follicle
created_by: tmeehan
creation_date: 2011-03-01T04:11:01Z

[Term]
id: CL:0002560
name: inner root sheath cell
namespace: cell
def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [GOC:tfm]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell
intersection_of: CL:0002559 ! hair follicle cell
intersection_of: part_of UBERON:0005941 ! hair inner root sheath
relationship: part_of UBERON:0005941 ! hair inner root sheath
created_by: tmeehan
creation_date: 2011-03-01T04:27:51Z

[Term]
id: CL:0002561
name: outer root sheath cell
namespace: cell
def: "An epithelial cell that is part of the outer root sheath." [GOC:tfm]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005942 ! hair outer root sheath
relationship: part_of UBERON:0005942 ! hair outer root sheath
created_by: tmeehan
creation_date: 2011-03-01T04:29:47Z

[Term]
id: CL:0002562
name: hair germinal matrix cell
namespace: cell
def: "An epidermal cell that is part of the germinal matrix." [GOC:tfm]
synonym: "trichocyte" EXACT []
is_a: CL:0000362 {is_inferred="true"} ! epidermal cell
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000362 ! epidermal cell
intersection_of: part_of UBERON:0006004 ! hair follicle matrix region
relationship: part_of UBERON:0006004 ! hair follicle matrix region
created_by: tmeehan
creation_date: 2011-03-01T04:31:06Z

[Term]
id: CL:0002563
name: intestinal epithelial cell
namespace: cell
def: "An epithelial cell of the intestine." [GOC:tfm]
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001277 ! intestinal epithelium
created_by: tmeehan
creation_date: 2011-03-01T05:18:31Z

[Term]
id: CL:0002564
name: nucleus pulposus cell of intervertebral disc
namespace: cell
def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm]
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0002242 ! nucleus pulposus
relationship: part_of UBERON:0002242 ! nucleus pulposus
created_by: tmeehan
creation_date: 2011-03-02T02:12:23Z

[Term]
id: CL:0002565
name: iris pigment epithelial cell
namespace: cell
def: "A pigment cell located in the epithelium of the iris." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata)
intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata)
intersection_of: part_of UBERON:0002506 ! iris epithelium
relationship: part_of UBERON:0002506 ! iris epithelium
created_by: tmeehan
creation_date: 2011-03-01T05:28:52Z

[Term]
id: CL:0002566
name: dark melanocyte
namespace: cell
def: "A melanocyte that appears darker due to content or amount of melanin granules." [GOC:tfm]
is_a: CL:0000148 ! melanocyte
created_by: tmeehan
creation_date: 2011-03-01T05:57:11Z

[Term]
id: CL:0002567
name: light melanocyte
namespace: cell
def: "A melanocyte that appears lighter in color." [GOC:tfm]
is_a: CL:0000148 ! melanocyte
created_by: tmeehan
creation_date: 2011-03-01T05:58:23Z

[Term]
id: CL:0002568
name: mesenchymal stem cell of Wharton's jelly
namespace: cell
def: "A mesenchymal stem cell that is part of Wharton's jelly." [GOC:tfm]
is_a: CL:0002569 ! mesenchymal stem cell of umbilical cord
created_by: tmeehan
creation_date: 2011-03-01T09:51:18Z

[Term]
id: CL:0002569
name: mesenchymal stem cell of umbilical cord
namespace: cell
def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord
relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord
created_by: tmeehan
creation_date: 2011-03-01T09:55:12Z

[Term]
id: CL:0002570
name: mesenchymal stem cell of adipose
namespace: cell
def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: part_of UBERON:0001013 ! adipose tissue
created_by: tmeehan
creation_date: 2011-03-01T09:57:17Z

[Term]
id: CL:0002571
name: hepatic mesenchymal stem cell
namespace: cell
def: "A mesenchymal stem cell of liver." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0002195 ! hepatic stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
created_by: tmeehan
creation_date: 2011-03-01T09:58:51Z

[Term]
id: CL:0002572
name: vertebral mesenchymal stem cell
namespace: cell
def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002412 ! vertebra
relationship: part_of UBERON:0002412 ! vertebra
created_by: tmeehan
creation_date: 2011-03-01T10:40:27Z

[Term]
id: CL:0002573
name: Schwann cell
namespace: cell
def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm]
xref: BTO:0001220
xref: CALOHA:TS-0898
is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata)
intersection_of: CL:0000243 ! glial cell (sensu Vertebrata)
intersection_of: part_of UBERON:0000010 ! peripheral nervous system
relationship: part_of UBERON:0000010 ! peripheral nervous system
created_by: tmeehan
creation_date: 2011-03-02T01:19:27Z

[Term]
id: CL:0002574
name: stromal cell of pancreas
namespace: cell
def: "A stromal cell of the pancreas." [GOC:tfm]
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
created_by: tmeehan
creation_date: 2011-03-02T02:40:41Z

[Term]
id: CL:0002575
name: central nervous system pericyte
namespace: cell
def: "A pericyte of the central nervous system." [GOC:tfm]
is_a: CL:0000669 {is_inferred="true"} ! pericyte cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000669 ! pericyte cell
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system
created_by: tmeehan
creation_date: 2011-03-02T02:54:18Z

[Term]
id: CL:0002576
name: perineural cell
namespace: cell
def: "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." [GO:tfm, http://en.wikipedia.org/wiki/Perineurium]
is_a: CL:0000186 {is_inferred="true"} ! myofibroblast cell
is_a: CL:0002319 ! neural cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000186 ! myofibroblast cell
intersection_of: part_of UBERON:0000121 ! perineurium
relationship: part_of UBERON:0000121 ! perineurium
created_by: tmeehan
creation_date: 2011-03-02T03:03:58Z

[Term]
id: CL:0002577
name: placental epithelial cell
namespace: cell
def: "An epithelial cell of the placenta." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: tmeehan
creation_date: 2011-03-02T03:21:30Z

[Term]
id: CL:0002578
name: mesenteric preadipocyte
namespace: cell
def: "A preadipocyte found in mesenteric tissue." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0002095 ! mesentery
relationship: part_of UBERON:0002095 ! mesentery
created_by: tmeehan
creation_date: 2011-03-03T04:19:40Z

[Term]
id: CL:0002579
name: omentum preadipocyte
namespace: cell
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0003688 ! omentum
relationship: part_of UBERON:0003688 ! omentum
created_by: tmeehan
creation_date: 2011-03-03T04:19:42Z

[Term]
id: CL:0002580
name: preadipocyte of the breast
namespace: cell
def: "A preadipocyte that is part of the breast." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0000310 ! breast
relationship: part_of UBERON:0000310 ! breast
created_by: tmeehan
creation_date: 2011-03-03T04:19:46Z

[Term]
id: CL:0002581
name: perirenal preadipocyte
namespace: cell
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0005406 ! perirenal fat
relationship: part_of UBERON:0005406 ! perirenal fat
created_by: tmeehan
creation_date: 2011-03-03T04:20:04Z

[Term]
id: CL:0002582
name: visceral preadipocyte
namespace: cell
def: "A preadipocyte that is part of visceral tissue." [GOC:tfm]
is_a: CL:0002334 ! preadipocyte
created_by: tmeehan
creation_date: 2011-03-03T04:32:56Z

[Term]
id: CL:0002583
name: subcutaneous preadipocyte
namespace: cell
def: "A preadipocyte that is part of subcutaneous tissue." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis
created_by: tmeehan
creation_date: 2011-03-03T04:33:01Z

[Term]
id: CL:0002584
name: renal cortical epithelial cell
namespace: cell
def: "An epithelial cell of the kidney cortex." [GOC:tfm]
xref: KUPO:0001016
is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell
is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: CL:0002585
name: retinal blood vessel endothelial cell
namespace: cell
def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm]
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina
created_by: tmeehan
creation_date: 2011-03-06T03:28:27Z

[Term]
id: CL:0002586
name: retinal pigment epithelial cell
namespace: cell
def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm]
xref: BTO:0004910
xref: FMA:75802
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001782 ! pigmented layer of retina
relationship: has_part GO:0042470 ! melanosome
relationship: part_of UBERON:0001782 ! pigmented layer of retina
created_by: tmeehan
creation_date: 2011-03-06T03:37:09Z

[Term]
id: CL:0002588
name: smooth muscle cell of the umbilical vein
namespace: cell
def: "A smooth muscle cell of the umbilical vein." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002066 ! umbilical vein
relationship: part_of UBERON:0002066 ! umbilical vein
created_by: tmeehan
creation_date: 2011-03-06T05:00:51Z

[Term]
id: CL:0002589
name: smooth muscle cell of the brachiocephalic vasculature
namespace: cell
def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001529 ! brachiocephalic artery
relationship: part_of UBERON:0001529 ! brachiocephalic artery
created_by: tmeehan
creation_date: 2011-03-06T05:00:58Z

[Term]
id: CL:0002590
name: smooth muscle cell of the brain vasculature
namespace: cell
def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
is_a: CL:0002319 ! neural cell
created_by: tmeehan
creation_date: 2011-03-06T05:01:20Z

[Term]
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
namespace: cell
def: "A smooth muscle of the pulmonary artery." [GOC:tfm]
xref: BTO:0003336
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
created_by: tmeehan
creation_date: 2011-03-06T05:01:28Z

[Term]
id: CL:0002592
name: smooth muscle cell of the coronary artery
namespace: cell
def: "A smooth muscle cell of the coronary artery." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001621 ! coronary artery
relationship: part_of UBERON:0001621 ! coronary artery
created_by: tmeehan
creation_date: 2011-03-06T05:01:34Z

[Term]
id: CL:0002593
name: smooth muscle cell of the internal thoracic artery
namespace: cell
def: "A smooth muscle of the internal thoracic artery." [GOC:tfm]
is_a: CL:0002595 ! smooth muscle cell of the subclavian artery
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002456 ! internal thoracic artery
relationship: part_of UBERON:0002456 ! internal thoracic artery
created_by: tmeehan
creation_date: 2011-03-06T05:01:41Z

[Term]
id: CL:0002594
name: smooth muscle cell of the umbilical artery
namespace: cell
def: "A smooth muscle cell of the umbilical artery." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: part_of UBERON:0001310 ! umbilical artery
created_by: tmeehan
creation_date: 2011-03-06T05:01:48Z

[Term]
id: CL:0002595
name: smooth muscle cell of the subclavian artery
namespace: cell
def: "A smooth muscle cell of the subclavian artery." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001533 ! subclavian artery
relationship: part_of UBERON:0001533 ! subclavian artery
created_by: tmeehan
creation_date: 2011-03-06T05:01:52Z

[Term]
id: CL:0002596
name: smooth muscle cell of the carotid artery
namespace: cell
def: "Smooth muscle cell of the carotid artery." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0005396 ! carotid artery segment
relationship: part_of UBERON:0005396 ! carotid artery segment
created_by: tmeehan
creation_date: 2011-03-06T05:01:56Z

[Term]
id: CL:0002597
name: smooth muscle cell of bladder
namespace: cell
def: "A smooth muscle cell of the bladder." [GC:tfm]
xref: KUPO:0001122
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
created_by: tmeehan
creation_date: 2011-03-06T05:43:24Z

[Term]
id: CL:0002598
name: bronchial smooth muscle cell
namespace: cell
xref: BTO:0004402
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus
created_by: tmeehan
creation_date: 2011-03-06T05:46:39Z

[Term]
id: CL:0002599
name: smooth muscle cell of the esophagus
namespace: cell
def: "A smooth muscle cell of the esophagus." [GOC:tfm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
created_by: tmeehan
creation_date: 2011-03-06T05:48:17Z

[Term]
id: CL:0002600
name: smooth muscle cell of trachea
namespace: cell
def: "A smooth muscle cell of the trachea." [GOC:tfm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea
created_by: tmeehan
creation_date: 2011-03-06T05:50:28Z

[Term]
id: CL:0002601
name: uterine smooth muscle cell
namespace: cell
def: "A smooth muscle cell of the uterus." [GOC:tfm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus
created_by: tmeehan
creation_date: 2011-03-06T05:53:28Z

[Term]
id: CL:0002602
name: annulus pulposus cell
namespace: cell
synonym: "anulus pulposus cell" EXACT []
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis
relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis
created_by: tmeehan
creation_date: 2011-03-06T06:50:53Z

[Term]
id: CL:0002603
name: astrocyte of the cerebellum
namespace: cell
def: "An astrocyte of the cerebellum." [GOC:tfm]
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
created_by: tmeehan
creation_date: 2011-03-06T06:57:27Z

[Term]
id: CL:0002604
name: astrocyte of the hippocampus
namespace: cell
is_a: CL:0002605 ! astrocyte of the cerebral cortex
is_a: CL:1001580 ! hippocampus glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn
created_by: tmeehan
creation_date: 2011-03-06T06:57:33Z

[Term]
id: CL:0002605
name: astrocyte of the cerebral cortex
namespace: cell
def: "An astrocyte of the cerebral cortex." [GOC:tfm]
is_a: CL:0012000 ! astrocyte of the forebrain
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
created_by: tmeehan
creation_date: 2011-03-06T06:57:36Z

[Term]
id: CL:0002606
name: astrocyte of the spinal cord
namespace: cell
def: "An astrocyte of the spinal cord." [GOC:tfm]
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord
created_by: tmeehan
creation_date: 2011-03-06T07:11:26Z

[Term]
id: CL:0002607
name: migratory enteric neural crest cell
namespace: cell
def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm]
is_a: CL:0000333 ! migratory neural crest cell
created_by: tmeehan
creation_date: 2011-03-06T07:24:35Z

[Term]
id: CL:0002608
name: hippocampal neuron
namespace: cell
def: "A neuron of the hippocampus." [GOC:tfm]
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn
created_by: tmeehan
creation_date: 2011-03-06T07:31:49Z

[Term]
id: CL:0002609
name: neuron of cerebral cortex
namespace: cell
def: "A CNS neuron of the cerebral cortex." [GOC:tfm]
synonym: "cortical neuron" EXACT []
xref: BTO:0004102
xref: FMA:84104
is_a: CL:0010012 ! cerebral cortex neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
created_by: tmeehan
creation_date: 2011-03-06T07:37:08Z

[Term]
id: CL:0002610
name: raphe nuclei neuron
namespace: cell
def: "A neuron of the raphe nuclei." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0004684 ! raphe nuclei
relationship: part_of UBERON:0004684 ! raphe nuclei
created_by: tmeehan
creation_date: 2011-03-06T07:42:06Z

[Term]
id: CL:0002611
name: neuron of the dorsal spinal cord
namespace: cell
def: "A CNS neuron of the dorsal spinal cord." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord
relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord
created_by: tmeehan
creation_date: 2011-03-06T07:43:34Z

[Term]
id: CL:0002612
name: neuron of the ventral spinal cord
namespace: cell
def: "A neuron of the ventral spinal cord." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord
relationship: part_of UBERON:0002257 ! ventral horn of spinal cord
created_by: tmeehan
creation_date: 2011-03-06T07:46:03Z

[Term]
id: CL:0002613
name: striatum neuron
namespace: cell
def: "A neuron of the striatum." [GOC:tfm]
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0002435 ! striatum
relationship: part_of UBERON:0002435 ! striatum
created_by: tmeehan
creation_date: 2011-03-06T07:47:12Z

[Term]
id: CL:0002614
name: neuron of the substantia nigra
namespace: cell
def: "A neuron of the substantia nigra." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0002038 ! substantia nigra
relationship: part_of UBERON:0002038 ! substantia nigra
created_by: tmeehan
creation_date: 2011-03-06T07:48:42Z

[Term]
id: CL:0002615
name: adipocyte of omentum tissue
namespace: cell
def: "A fat cell that is part of omentum tissue." [GOC:tfm]
synonym: "omental adipocyte" EXACT []
synonym: "omental fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! fat cell
intersection_of: CL:0000136 ! fat cell
intersection_of: part_of UBERON:0003688 ! omentum
relationship: part_of UBERON:0003688 ! omentum
created_by: tmeehan
creation_date: 2011-03-14T10:17:00Z

[Term]
id: CL:0002616
name: perirenal adipocyte cell
namespace: cell
def: "A fat cell of perirenal fat tissue." [GOC:tfm]
synonym: "perirenal fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! fat cell
intersection_of: CL:0000136 ! fat cell
intersection_of: part_of UBERON:0005406 ! perirenal fat
relationship: part_of UBERON:0005406 ! perirenal fat
created_by: tmeehan
creation_date: 2011-03-14T10:17:05Z

[Term]
id: CL:0002617
name: adipocyte of breast
namespace: cell
def: "A fat cell that is part of the breast." [GOC:tfm]
comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]
synonym: "breast adipocyte" EXACT []
synonym: "fat cell of breast" EXACT []
xref: CALOHA:TS-2377
is_a: CL:0000136 {is_inferred="true"} ! fat cell
intersection_of: CL:0000136 ! fat cell
intersection_of: part_of UBERON:0000310 ! breast
relationship: part_of UBERON:0000310 ! breast
created_by: tmeehan
creation_date: 2011-03-14T10:17:07Z

[Term]
id: CL:0002618
name: endothelial cell of umbilical vein
namespace: cell
def: "An endothelial cell of the umbilical vein." [GOC:tfm]
xref: BTO:0004296
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002066 ! umbilical vein
relationship: part_of UBERON:0002066 ! umbilical vein
created_by: tmeehan
creation_date: 2011-03-14T11:36:51Z

[Term]
id: CL:0002619
name: adult endothelial progenitor cell
namespace: cell
def: "An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial." [GOC:tfm, PMID:20807818, PMID:9020076]
synonym: "EPC" EXACT []
is_a: CL:0000566 ! angioblastic mesenchymal cell
created_by: tmeehan
creation_date: 2011-03-14T12:11:18Z

[Term]
id: CL:0002620
name: skin fibroblast
namespace: cell
def: "A fibroblast of skin." [GOC:tfm]
xref: BTO:0001255
xref: CALOHA:TS-0935
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body
created_by: tmeehan
creation_date: 2011-03-14T12:31:49Z

[Term]
id: CL:0002621
name: gingival epithelial cell
namespace: cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001949 ! gingival epithelium
relationship: part_of UBERON:0001949 ! gingival epithelium
created_by: tmeehan
creation_date: 2011-03-14T12:46:28Z

[Term]
id: CL:0002622
name: prostate stromal cell
namespace: cell
def: "A stromal cell of the prostate." [GOC:tfm]
xref: BTO:0003972
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
created_by: tmeehan
creation_date: 2011-03-14T02:11:10Z

[Term]
id: CL:0002623
name: acinar cell of salivary gland
namespace: cell
def: "An acinar cell of salivary gland." [GOC:tfm]
is_a: CL:0000622 {is_inferred="true"} ! acinar cell
is_a: CL:1001596 ! salivary gland glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland
created_by: tmeehan
creation_date: 2011-03-14T02:22:22Z

[Term]
id: CL:0002624
name: paneth cell of the appendix
namespace: cell
def: "A paneth cell of the appendix." [GOC:tfm]
is_a: CL:0000510 {is_inferred="true"} ! paneth cell
is_a: CL:1001585 ! appendix glandular cell
intersection_of: CL:0000510 ! paneth cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix
created_by: tmeehan
creation_date: 2011-03-15T09:38:18Z

[Term]
id: CL:0002625
name: seminiferous tubule epithelial cell
namespace: cell
def: "A cell of the seminiferous tubule epithelium." [GOC:tfm]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium
created_by: tmeehan
creation_date: 2011-03-15T11:59:23Z

[Term]
id: CL:0002626
name: immature astrocyte
namespace: cell
def: "An immature astrocyte." [GOC:dsd]
synonym: "immature astrocytic glia" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0002627
name: mature astrocyte
namespace: cell
def: "A mature astrocyte that is capable of producing cytokines." [GOC:dsd, PMID:12898703, PMID:8734446]
comment: Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta.
synonym: "activated astrocyte" EXACT []
synonym: "mature astrocytic glia" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0002628
name: immature microglial cell
namespace: cell
def: "An immature microglial cell with a ramified morphology." [GOC:dsd, PMID:18396103, PMID:19461673]
comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative.
synonym: "immature microglia" EXACT []
synonym: "quiescent microglia" EXACT [PMID:18396103]
synonym: "resting microglia" EXACT [PMID:18396103]
is_a: CL:0000129 ! microglial cell

[Term]
id: CL:0002629
name: mature microglial cell
namespace: cell
def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [GOC:dsd, PMID:11517395, PMID:14612429, PMID:15246020, PMID:16177057, PMID:18396103, PMID:20021364]
comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha.
synonym: "activated microglia" EXACT [PMID:18396103]
synonym: "mature microglia" EXACT []
synonym: "reactive microglia" EXACT [PMID:18396103]
is_a: CL:0000129 {is_inferred="true"} ! microglial cell
intersection_of: CL:0000129 ! microglial cell
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0002536 ! respiratory burst involved in inflammatory response
intersection_of: capable_of GO:0002537 ! nitric oxide production involved in inflammatory response
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0002536 ! respiratory burst involved in inflammatory response
relationship: capable_of GO:0002537 ! nitric oxide production involved in inflammatory response
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0019882 ! antigen processing and presentation

[Term]
id: CL:0002630
name: actinomycete-type spore
namespace: cell
def: "A spore formed from bacteria in the order Actinomycetales." [GO:0034304, GOC:tfm]
is_a: CL:0000520 ! prokaryotic cell
created_by: tmeehan
creation_date: 2011-06-16T01:01:41Z

[Term]
id: CL:0002631
name: epithelial cell of upper respiratory tract
namespace: cell
is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell
intersection_of: CL:0002368 ! respiratory epithelial cell
intersection_of: part_of UBERON:0001557 ! upper respiratory tract
relationship: part_of UBERON:0001557 ! upper respiratory tract
created_by: tmeehan
creation_date: 2011-06-21T12:28:55Z

[Term]
id: CL:0002632
name: epithelial cell of lower respiratory tract
namespace: cell
is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell
intersection_of: CL:0002368 ! respiratory epithelial cell
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract
created_by: tmeehan
creation_date: 2011-06-21T12:29:31Z

[Term]
id: CL:0002633
name: respiratory basal cell
namespace: cell
def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479]
synonym: "airway basal cell" EXACT []
synonym: "airway basal stem cell" EXACT []
is_a: CL:0000646 ! basal cell
is_a: CL:0002368 ! respiratory epithelial cell
created_by: tmeehan
creation_date: 2011-06-21T03:11:10Z

[Term]
id: CL:0002634
name: epithelial cell of anal column
namespace: cell
def: "An epithelial cell of the anal column." [GOC:tfm]
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0009882 ! anal column
relationship: part_of UBERON:0009882 ! anal column
created_by: tmeehan
creation_date: 2011-07-08T12:11:38Z

[Term]
id: CL:0002635
name: nonkeratinized epithelial cell of anal column
namespace: cell
def: "A nonkeratinized epithelial cell of the anal canal." [GOC:tfm]
xref: FMA:263146
is_a: CL:0002634 ! epithelial cell of anal column
created_by: tmeehan
creation_date: 2011-07-08T02:05:33Z

[Term]
id: CL:0002636
name: nonkeratinized epithelial cell of inferior part of anal canal
namespace: cell
def: "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." [GOC:tfm]
xref: FMA:263144
is_a: CL:0002635 ! nonkeratinized epithelial cell of anal column
is_a: CL:1000438 ! epithelial cell of wall of inferior part of anal canal
created_by: tmeehan
creation_date: 2011-07-08T02:06:53Z

[Term]
id: CL:0002637
name: keratinized epithelial cell of the anal canal
namespace: cell
def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm]
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0002634 ! epithelial cell of anal column
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal
created_by: tmeehan
creation_date: 2011-07-08T02:08:40Z

[Term]
id: CL:0002638
name: bronchioalveolar stem cell
namespace: cell
def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and Clara cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [GOC:tfm, PMID:15960971]
synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT []
synonym: "BASC" EXACT []
is_a: CL:1000350 ! basal cell of epithelium of terminal bronchiole
is_a: CL:1000351 ! basal cell of epithelium of respiratory bronchiole
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium
created_by: tmeehan
creation_date: 2011-06-21T03:26:08Z

[Term]
id: CL:0002639
name: amniotic stem cell
namespace: cell
def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [GOC:tfm, PMID:20942606]
comment: Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now.
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002323 ! amniocyte
created_by: tmeehan
creation_date: 2011-06-21T03:55:39Z

[Term]
id: CL:0002640
name: amniotic epithelial stem cell
namespace: cell
def: "An epithelial fate stem cell derived form the amnion membrane." [GOC:tfm, PMID:20446274]
is_a: CL:0000036 ! epithelial fate stem cell
created_by: tmeehan
creation_date: 2011-06-21T04:06:17Z

[Term]
id: CL:0002641
name: epithelial cell of esophageal gland proper
namespace: cell
def: "An epithelial cell of the esophageal gland proper." [GOC:tfm]
xref: FMA:256141
is_a: CL:0002657 ! glandular cell of esophagus
created_by: tmeehan
creation_date: 2011-07-08T02:16:51Z

[Term]
id: CL:0002642
name: epithelial cell of esophageal cardiac gland
namespace: cell
def: "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." [GOC:tfm, http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html]
xref: FMA:256143
is_a: CL:0002657 ! glandular cell of esophagus
created_by: tmeehan
creation_date: 2011-07-08T02:16:54Z

[Term]
id: CL:0002643
name: nonkeratinized cell of stratum corneum of esophageal epithelium
namespace: cell
def: "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." [GOC:tfm]
xref: FMA:263148
is_a: CL:0002654 ! epithelial cell of stratum corneum of esophageal epithelium
created_by: tmeehan
creation_date: 2011-07-08T02:22:09Z

[Term]
id: CL:0002644
name: endo-epithelial cell of tympanic part of viscerocranial mucosa
namespace: cell
def: "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70628
is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa
created_by: tmeehan
creation_date: 2011-07-08T02:25:44Z

[Term]
id: CL:0002645
name: endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa
namespace: cell
def: "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." [GOC:tfm]
xref: FMA:70629
is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa
created_by: tmeehan
creation_date: 2011-07-08T02:25:46Z

[Term]
id: CL:0002646
name: obsolete epithelial cell of buccal part of viscerocranial mucosa
namespace: cell
def: "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70577
is_obsolete: true
created_by: tmeehan
creation_date: 2011-07-08T02:34:12Z

[Term]
id: CL:0002647
name: obsolete epithelial cell of anterior palatal part of viscerocranial mucosa
namespace: cell
def: "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70580
is_obsolete: true
created_by: tmeehan
creation_date: 2011-07-08T02:34:14Z

[Term]
id: CL:0002648
name: obsolete epithelial cell of nasal part of viscerocranial mucosa
namespace: cell
def: "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70554
is_obsolete: true
created_by: tmeehan
creation_date: 2011-07-08T02:36:06Z

[Term]
id: CL:0002649
name: obsolete epithelial cell of gingival part of viscerocranial mucosa
namespace: cell
def: "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70579
is_obsolete: true
created_by: tmeehan
creation_date: 2011-07-08T02:36:11Z

[Term]
id: CL:0002650
name: obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa
namespace: cell
def: "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70578
is_obsolete: true
created_by: tmeehan
creation_date: 2011-07-08T02:38:18Z

[Term]
id: CL:0002651
name: endothelial cell of venous sinus of spleen
namespace: cell
def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [GOC:tfm]
synonym: "stave cell" EXACT [FMA:62817]
xref: FMA:72140
is_a: CL:0002262 ! endothelial cell of sinusoid
created_by: tmeehan
creation_date: 2011-07-08T03:06:49Z

[Term]
id: CL:0002652
name: endothelial cell of high endothelial venule
namespace: cell
def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [GOC:tfm, PMID:20726857]
comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG.
synonym: "endothelial cell of postcapillary venule of lymph node" EXACT []
synonym: "HEV cell" EXACT []
xref: FMA:67759
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:1000414 ! endothelial cell of venule
created_by: tmeehan
creation_date: 2011-07-08T03:14:10Z

[Term]
id: CL:0002653
name: squamous endothelial cell
namespace: cell
def: "A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." [GOC:tfm]
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:1000414 ! endothelial cell of venule
created_by: tmeehan
creation_date: 2011-07-08T03:31:25Z

[Term]
id: CL:0002654
name: epithelial cell of stratum corneum of esophageal epithelium
namespace: cell
def: "An epithelial cell of stratum corneum of esophageal epithelium." [GOC:tfm]
xref: FMA:70733
is_a: CL:0002252 ! epithelial cell of esophagus
created_by: tmeehan
creation_date: 2011-07-08T03:46:35Z

[Term]
id: CL:0002655
name: epithelial cell of stratum spinosum of esophageal epithelium
namespace: cell
def: "An epithelial cell of stratum spinosum of esophageal epithelium." [GOC:tfm]
xref: FMA:70732
is_a: CL:0002252 ! epithelial cell of esophagus
created_by: tmeehan
creation_date: 2011-07-08T03:48:26Z

[Term]
id: CL:0002656
name: glandular cell of endometrium
namespace: cell
def: "A glandular epithelial cell of the endometrium." [GOC:tfm]
xref: FMA:86489
is_a: CL:1001591 ! oviduct glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium
created_by: tmeehan
creation_date: 2011-07-08T03:54:08Z

[Term]
id: CL:0002657
name: glandular cell of esophagus
namespace: cell
def: "A glandular epithelial cell of the esophagus." [GOC:tfm]
xref: FMA:86548
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
created_by: tmeehan
creation_date: 2011-07-08T03:55:57Z

[Term]
id: CL:0002658
name: glandular cell of the large intestine
namespace: cell
def: "A glandular epithelial cell of the large intestine." [GOC:tfm]
xref: FMA:87194
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
created_by: tmeehan
creation_date: 2011-07-08T04:03:01Z

[Term]
id: CL:0002659
name: glandular cell of stomach
namespace: cell
def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm]
xref: CALOHA:TS-1284
xref: FMA:86554
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
created_by: tmeehan
creation_date: 2011-07-11T01:20:35Z

[Term]
id: CL:0002660
name: luminal cell of acinus of lactiferous gland
namespace: cell
def: "A luminal epithelial cell of mammary gland located in acinus of structure." [GOC:tfm]
comment: Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type.
xref: FMA:74505
is_a: CL:0002326 ! luminal epithelial cell of mammary gland
created_by: tmeehan
creation_date: 2011-07-11T01:44:31Z

[Term]
id: CL:0002661
name: luminal cell of lactiferous terminal ductal lobular unit
namespace: cell
def: "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." [GOC:tfm]
xref: FMA:87168
is_a: CL:0002662 ! luminal cell of lactiferous duct
created_by: tmeehan
creation_date: 2011-07-11T01:44:33Z

[Term]
id: CL:0002662
name: luminal cell of lactiferous duct
namespace: cell
def: "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." [GOC:tfm, PMID:19022771]
xref: FMA:74504
xref: FMA:74505
is_a: CL:0002326 ! luminal epithelial cell of mammary gland
created_by: tmeehan
creation_date: 2011-07-11T01:44:48Z

[Term]
id: CL:0002663
name: myocardial endocrine cell of atrium
namespace: cell
def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm]
xref: FMA:83389
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium
created_by: tmeehan
creation_date: 2011-07-11T02:45:39Z

[Term]
id: CL:0002664
name: cardioblast
namespace: cell
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164]
comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
is_a: CL:0000048 ! multi fate stem cell
created_by: tmeehan
creation_date: 2011-07-11T03:15:38Z

[Term]
id: CL:0002665
name: otic fibrocyte
namespace: cell
def: "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." [GOC:tfm, PMID:18353863]
is_a: CL:0000135 ! fibrocyte
relationship: part_of UBERON:0006725 ! spiral ligament
created_by: tmeehan
creation_date: 2011-07-11T03:35:01Z

[Term]
id: CL:0002666
name: type 2 otic fibrocyte
namespace: cell
def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863]
synonym: "type II otic fibrocyte" EXACT []
synonym: "type II spiral ligament fibrocyte" EXACT [MP:0004488]
is_a: CL:0002665 ! otic fibrocyte
created_by: tmeehan
creation_date: 2011-07-11T03:40:40Z

[Term]
id: CL:0002667
name: type 5 otic fibrocyte
namespace: cell
def: "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863]
synonym: "type V otic fibrocyte" EXACT []
synonym: "type V spiral ligament fibrocyte" EXACT []
is_a: CL:0002665 ! otic fibrocyte
created_by: tmeehan
creation_date: 2011-07-11T03:40:42Z

[Term]
id: CL:0002668
name: type 4 otic fibrocyte
namespace: cell
def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [GOC:tfm, PMID:18353863]
synonym: "type IV otic fibrocyte" EXACT []
synonym: "type IV spiral ligament fibrocyte" EXACT [MP:0004490]
is_a: CL:0002665 ! otic fibrocyte
created_by: tmeehan
creation_date: 2011-07-11T03:40:46Z

[Term]
id: CL:0002669
name: type 3 otic fibrocyte
namespace: cell
def: "An otic fibrocyte that lines the otic capsule." [GOC:tfm, PMID:18353863]
synonym: "type III otic fibrocyte" EXACT []
synonym: "type III spiral ligament fibrocyte" EXACT [MP:0004489]
is_a: CL:0002665 ! otic fibrocyte
created_by: tmeehan
creation_date: 2011-07-11T03:40:50Z

[Term]
id: CL:0002670
name: type 1 otic fibrocyte
namespace: cell
def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863]
synonym: "type I otic fibrocyte" EXACT []
synonym: "type I spiral ligament fibrocyte" EXACT [MP:0004487]
is_a: CL:0002665 ! otic fibrocyte
created_by: tmeehan
creation_date: 2011-07-11T03:39:27Z

[Term]
id: CL:0002671
name: endothelial stalk cell
namespace: cell
def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [GOC:tfm, PMID:21521739]
is_a: CL:0000071 ! blood vessel endothelial cell
created_by: tmeehan
creation_date: 2011-08-16T01:49:32Z

[Term]
id: CL:0002672
name: retinal progenitor cell
namespace: cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186]
is_a: CL:0000048 ! multi fate stem cell
relationship: develops_from CL:0000133 ! neurectodermal cell
created_by: tmeehan
creation_date: 2011-08-16T02:38:01Z

[Term]
id: CL:0002673
name: tongue muscle cell
namespace: cell
def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858]
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0000378 ! tongue muscle
relationship: part_of UBERON:0000378 ! tongue muscle
created_by: tmeehan
creation_date: 2011-08-16T03:10:02Z

[Term]
id: CL:0002674
name: H minus
namespace: cell
def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [GOC:tfm]
synonym: "H- cell" EXACT []
is_a: CL:0000521 ! fungal cell
created_by: tmeehan
creation_date: 2011-08-16T03:20:53Z

[Term]
id: CL:0002675
name: H plus
namespace: cell
def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [GOC:tfm]
is_a: CL:0000521 ! fungal cell
created_by: tmeehan
creation_date: 2011-08-16T03:20:58Z

[Term]
id: CL:0002676
name: neural crest derived neuroblast
namespace: cell
def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019]
is_a: CL:0000337 ! neuroblast (sensu Vertebrata)
relationship: develops_from CL:0000333 ! migratory neural crest cell
created_by: tmeehan
creation_date: 2011-08-22T09:24:15Z

[Term]
id: CL:0002677
name: naive regulatory T cell
namespace: cell
def: "A regulatory T cell that has not encountered antigen." [GOC:tfm]
comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell.
synonym: "naive regulatory T lymphocyte" EXACT []
synonym: "naive regulatory T-cell" EXACT []
synonym: "naive regulatory T-lymphocyte" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
is_a: CL:0000898 ! naive T cell
created_by: tmeehan
creation_date: 2011-08-25T03:17:21Z

[Term]
id: CL:0002678
name: memory regulatory T cell
namespace: cell
def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [GOC:tfm, PMID:21739668]
comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell.
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
is_a: CL:0000813 ! memory T cell
created_by: tmeehan
creation_date: 2011-08-25T03:17:34Z

[Term]
id: CL:0002679
name: natural helper lymphocyte
namespace: cell
def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630]
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
intersection_of: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1
relationship: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex
relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule
relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X
relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon
relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein
relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76
created_by: tmeehan
creation_date: 2011-08-29T10:08:02Z

[Term]
id: CL:0002680
name: PP cell of intestine
namespace: cell
def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970]
is_a: CL:0000696 {is_inferred="true"} ! PP cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
created_by: tmeehan
creation_date: 2011-09-27T11:59:01Z

[Term]
id: CL:0002681
name: kidney cortical cell
namespace: cell
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney
created_by: terryh
creation_date: 2011-10-25T03:49:41Z

[Term]
id: CL:0005000
name: spinal cord interneuron
namespace: cell
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: CL:0005001
name: iridoblast
namespace: cell
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS]
comment: Derived from UBERON:0002342 neural crest.
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0005002
name: xanthoblast
namespace: cell
def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0005003
name: leucoblast
namespace: cell
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0005004
name: pigment erythroblast
namespace: cell
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0005005
name: cyanoblast
namespace: cell
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0005006
name: ionocyte
namespace: cell
def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0005007
name: Kolmer-Agduhr neuron
namespace: cell
def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739]
synonym: "KA cell" EXACT []
synonym: "KA interneuron" EXACT [PMID:15539490]
synonym: "KA neuron" EXACT [PMID:9634146]
synonym: "Kolmer-Agduhr cell" EXACT []
is_a: CL:0005000 ! spinal cord interneuron
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:0005008
name: macular hair cell
namespace: cell
def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs]
is_a: CL:0000202 ! auditory hair cell
intersection_of: CL:0000202 ! auditory hair cell
intersection_of: part_of UBERON:0000054 ! macula
relationship: part_of UBERON:0000054 ! macula

[Term]
id: CL:0005009
name: renal principal cell
namespace: cell
def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts." [CL:CVS]
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002518 ! kidney epithelial cell

[Term]
id: CL:0005010
name: renal intercalated cell
namespace: cell
def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS]
synonym: "intercalated cell" EXACT []
xref: FMA:86560
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:0002518 ! kidney epithelial cell

[Term]
id: CL:0005011
name: renal alpha-intercalated cell
namespace: cell
def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS]
is_a: CL:0005010 ! renal intercalated cell

[Term]
id: CL:0005012
name: multi-ciliated epithelial cell
namespace: cell
def: "A ciliated epithelial cell with many cilium." [CL:CVS]
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0005013
name: single ciliated epithelial cell
namespace: cell
def: "A ciliated epithelial cell with a single cilium." [CL:CVS]
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
relationship: has_plasma_membrane_part GO:0005929 ! cilium

[Term]
id: CL:0005014
name: auditory epithelial support cell
namespace: cell
def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm]
is_a: CL:0000630 ! supportive cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002491 ! auditory epithelial cell

[Term]
id: CL:0005015
name: inner phalangeal cell
namespace: cell
def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS]
xref: FMA:79801
is_a: CL:0002165 ! phalangeal cell

[Term]
id: CL:0005016
name: obsolete apical cell
namespace: cell
def: "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB]
comment: replaced_by: PO:0030007
is_obsolete: true

[Term]
id: CL:0005017
name: obsolete plant basal cell
namespace: cell
def: "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." [TAIR:TB]
comment: replaced_by: PO:0002002
is_obsolete: true

[Term]
id: CL:0005018
name: ghrelin secreting cell
namespace: cell
def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator]
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036321 ! ghrelin secretion
relationship: capable_of GO:0036321 ! ghrelin secretion

[Term]
id: CL:0005019
name: pancreatic epsilon cell
namespace: cell
def: "Ghrelin secreting cells found in the found in the exocrine pancreas." [PMID:14970313]
comment: In mammals the endocrine pancreas is called the Islets of Langerhans.
synonym: "pancreatic E cell" EXACT []
is_a: CL:0005018 ! ghrelin secreting cell

[Term]
id: CL:0005020
name: lymphangioblast
namespace: cell
def: "Lymphatic progenitor cells. " [CL:CVS]
comment: Usually express Prox1, or prox1b.
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: adjacent_to UBERON:0004536 ! lymph vasculature
relationship: adjacent_to UBERON:0004536 ! lymph vasculature
created_by: Ceri
creation_date: 2012-01-12T04:44:34Z

[Term]
id: CL:0005021
name: mesenchymal lymphangioblast
namespace: cell
def: "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." [PMID:15624319, PMID:18430230]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0005020 ! lymphangioblast
created_by: Ceri
creation_date: 2012-01-12T05:01:22Z

[Term]
id: CL:0005022
name: vascular lymphangioblast
namespace: cell
def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS]
synonym: "parachordal lymphangioblast" NARROW []
is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast
intersection_of: CL:0005020 ! lymphangioblast
intersection_of: adjacent_to UBERON:0001638 ! vein
relationship: adjacent_to UBERON:0001638 ! vein
created_by: Ceri
creation_date: 2012-01-12T05:21:09Z

[Term]
id: CL:0005023
name: branchiomotor neuron
def: "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." [ZFIN:CVS]
synonym: "branchi  motor neuron " EXACT []
synonym: "special visceral motor neuron" EXACT []
xref: PMID:14699587 
is_a: CL:0015000 ! cranial motor neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: has_synaptic_terminal_in UBERON:0004164 ! branchiomeric muscle
relationship: has_synaptic_terminal_in UBERON:0004164 ! branchiomeric muscle

[Term]
id: CL:0005024
name: somatomotor neuron
def: "A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic." [ZFIN:CVS]
synonym: "somatic motor neuron" EXACT []
is_a: CL:0000108 ! cholinergic neuron
is_a: CL:0008014 ! excitatory motor neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ
relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ

[Term]
id: CL:0005025
name: visceromotor neuron
def: "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." [ZFIN:CVS]
comment: Note that these neurons do not synapse directly onto muscles
synonym: "general visceral motor neuron" EXACT []
is_a: CL:0000100 ! motor neuron
relationship: synapsed_to CL:0011102 ! parasympathetic neuron

[Term]
id: CL:0005026
name: hepatoblast
def: "Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants." [GOC:CVS, PMID:18356246, PMID:20483998 ]
is_a: CL:0000048 ! multi fate stem cell

[Term]
id: CL:0007000
name: preameloblast
namespace: cell
def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325]
comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: adjacent_to UBERON:0001763 ! odontogenic papilla
relationship: develops_from CL:0002077 ! ecto-epithelial cell
relationship: part_of UBERON:0005176 ! tooth enamel organ
created_by: haendel
creation_date: 2012-06-15T01:27:01Z

[Term]
id: CL:0007001
name: skeletogenic cell
namespace: cell
def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034]
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)
synonym: "scleroblast" EXACT [GO_REF:0000034]
is_a: CL:0000003 ! native cell
created_by: haendel
creation_date: 2012-06-15T02:51:27Z

[Term]
id: CL:0007002
name: precementoblast
namespace: cell
def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: part_of UBERON:0005176 ! tooth enamel organ
created_by: haendel
creation_date: 2012-06-15T04:37:13Z

[Term]
id: CL:0007003
name: preodontoblast
namespace: cell
def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0005176 ! tooth enamel organ
created_by: haendel
creation_date: 2012-06-15T05:15:11Z

[Term]
id: CL:0007004
name: premigratory neural crest cell
namespace: cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
is_a: CL:0011012 ! neural crest cell
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0002342 ! neural crest
created_by: haendel
creation_date: 2012-06-27T08:27:35Z

[Term]
id: CL:0007005
name: notochordal cell
namespace: cell
def: "Cell that is part of the notochord." [GO_REF:0000034]
comment: NOTE: TO DO, notochord development still needs work.
is_a: CL:0000003 ! native cell
relationship: develops_from CL:0007006 ! chordamesodermal cell
relationship: part_of UBERON:0002328 ! notochord
created_by: haendel
creation_date: 2012-06-27T08:47:31Z

[Term]
id: CL:0007006
name: chordamesodermal cell
namespace: cell
def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [GO_REF:0000034]
synonym: "axial mesodermal cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
relationship: part_of UBERON:0004880 ! chordamesoderm
created_by: haendel
creation_date: 2012-06-27T08:52:41Z

[Term]
id: CL:0007007
name: notochordal sheath cell
namespace: cell
def: "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." [CL:MAH]
is_a: CL:0007005 ! notochordal cell
created_by: haendel
creation_date: 2012-06-27T09:26:37Z

[Term]
id: CL:0007008
name: notochordal vacuole cell
namespace: cell
def: "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." [CL:MAH]
synonym: "chordablast" EXACT [GO_REF:0000034]
synonym: "chordoblast" EXACT [PMID:14574572]
is_a: CL:0007005 ! notochordal cell
created_by: haendel
creation_date: 2012-06-27T09:29:30Z

[Term]
id: CL:0007009
name: prechondroblast
namespace: cell
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034]
is_a: CL:0000055 ! non-terminally differentiated cell
created_by: haendel
creation_date: 2012-06-27T10:44:01Z

[Term]
id: CL:0007010
name: preosteoblast
namespace: cell
def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [GO_REF:0000034]
synonym: "osteoprogenitor cell" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: part_of UBERON:0008883 ! osteoid
created_by: haendel
creation_date: 2012-06-27T10:57:21Z

[Term]
id: CL:0007011
name: enteric neuron
namespace: cell
def: "Neuron that is part of the enteric nervous system." [CL:MAH]
is_a: CL:0000029 ! neuron neural crest derived
is_a: CL:0000107 ! autonomic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002005 ! enteric nervous system
relationship: develops_from CL:0002607 ! migratory enteric neural crest cell
relationship: part_of UBERON:0002005 ! enteric nervous system
created_by: haendel
creation_date: 2012-06-28T08:20:31Z

[Term]
id: CL:0007012
name: non-terminally differentiated odontoblast
namespace: cl
def: "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." [GO_REF:0000034, PSPUB:0000170]
is_a: CL:0000060 ! odontoblast

[Term]
id: CL:0007013
name: terminally differentiated odontoblast
namespace: cl
def: "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." [GO_REF:0000034]
is_a: CL:0000060 ! odontoblast

[Term]
id: CL:0007014
name: obsolete cell line cell
namespace: cell
def: "OBSOLETE: A cultured cell that has been passaged at least one time in culture." [ReO:mhb]
comment: Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use.
synonym: "passaged cultured cell" EXACT []
is_obsolete: true
replaced_by: CLO:0000001
created_by: haendel
creation_date: 2012-11-28T11:54:59Z

[Term]
id: CL:0007015
name: obsolete mortal cell line cell
namespace: cell
def: "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." [ReO:mhb]
comment: Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use.
synonym: "finite cell line cell" EXACT []
synonym: "primary cell line cell" RELATED []
is_obsolete: true
replaced_by: CLO:0000018
created_by: haendel
creation_date: 2012-11-28T11:56:20Z

[Term]
id: CL:0007016
name: adaxial cell
namespace: cell
def: "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." [PMID:8951054]
comment: In teleosts, adaxial cells give rise to slow muscle myoblasts.
is_a: CL:0000680 ! muscle precursor cell
relationship: part_of UBERON:0003059 ! presomitic mesoderm
created_by: haendel
creation_date: 2012-12-30T12:43:15Z

[Term]
id: CL:0007017
name: Stiftchenzellen
def: "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis. " [PMID:1087183]
comment: Taxon specificity not yet fully known, but are known in anuran larvae but not in adults.
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: has_part GO:0005902 ! microvillus
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: haendel

[Term]
id: CL:0007018
name: epidermal ciliary cell
def: "Ciliated cell of the embryonic epidermis and functions in embryonic movements." [PMCID:PMC3046089]
comment: Taxon specificity not clear -present in embryonic anurans.
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002321 ! embryonic cell
relationship: has_plasma_membrane_part GO:0005929 ! cilium
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: haendel

[Term]
id: CL:0007019
name: epidermal mucus secreting cell
comment: taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis.
is_a: CL:0000319 ! mucus secreting cell
created_by: haendel

[Term]
id: CL:0007020
name: bottle cell
def: "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." [PMID:3197630]
is_a: CL:0000007 ! early embryonic cell
created_by: haendel

[Term]
id: CL:0007021
name: alarm substance cell
def: "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" [ISBN-10:0412429403]
synonym: "club cell" EXACT [ISBN-10:0412429403]
is_a: CL:0000151 ! secretory cell
is_a: CL:0000473 ! defensive cell
relationship: capable_of GO:0032940 ! secretion by cell
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: haendel

[Term]
id: CL:0007022
name: micropylar cell
def: "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." [PMID:18582455 , ZFA:0005239]
synonym: "plug cell" EXACT []
is_a: CL:0000548 ! animal cell
relationship: part_of UBERON:0001305 ! ovarian follicle
created_by: haendel

[Term]
id: CL:0007023
name: flask cell
def: "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis. " [DOI:10.1007/BF00717048]
is_a: CL:0000003 ! native cell
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: haendel

[Term]
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0008001
name: hematopoietic precursor cell
def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos]
is_a: CL:0000988 ! hematopoietic cell

[Term]
id: CL:0008002
name: skeletal muscle fiber
def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0002372 ! myotube
intersection_of: CL:0000187 ! muscle cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
intersection_of: bearer_of PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0002478 ! transversely striated
relationship: develops_from CL:0000515 ! skeletal muscle myoblast
relationship: has_part GO:0030017 ! sarcomere
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0008003
name: somatic muscle myotube
def: "A myotube that is part of some somatic muscle.  Examples include arthropod somatic muscle cells." [PMID:22274696, PMID:8720463]
is_a: CL:0002372 ! myotube
is_a: CL:0008004 ! somatic muscle cell
intersection_of: CL:0008004 ! somatic muscle cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
intersection_of: bearer_of PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0002478 ! transversely striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0008004
name: somatic muscle cell
def: "A muscle cell that is part of some somatic muscle." [GOC:dos]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0008005
name: obliquely striated somatic muscle cell
def: "A somatic muscle cell that is oblquely striated.  Examples include the somatic muscles of nematodes." [PMID:8720463]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000444 ! obliquely striated muscle cell
is_a: CL:0008004 ! somatic muscle cell
intersection_of: CL:0008004 ! somatic muscle cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
intersection_of: bearer_of PATO:0002479 ! obliquely striated
intersection_of: has_part GO:0030017 ! sarcomere
relationship: bearer_of PATO:0001908 ! multinucleate
relationship: bearer_of PATO:0002479 ! obliquely striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0008006
name: muscle founder cell
namespace: cell
def: "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) .  It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." [PMID:22274696]
is_a: CL:0008018 ! somatic muscle myoblast
relationship: develops_into CL:0008003 ! somatic muscle myotube

[Term]
id: CL:0008007
name: visceral muscle cell
def: "A muscle cell that is part of some visceral muscle" [GOC:dos]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0008008
name: striated visceral muscle cell
def: "A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods." [GOC:dos]
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: bearer_of PATO:0001410 {all_some="true"} ! striated

[Term]
id: CL:0008009
name: transversely striated visceral muscle cell
def: "A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods." [GOC:dos]
is_a: CL:0008008 ! striated visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: bearer_of PATO:0002478 {all_some="true"} ! transversely striated

[Term]
id: CL:0008010
name: cranial somatomotor neuron
def: "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." [PMID:14699587]
is_a: CL:0005024 ! somatomotor neuron
is_a: CL:0015000 ! cranial motor neuron
intersection_of: CL:0015000 ! cranial motor neuron
intersection_of: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ
relationship: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ

[Term]
id: CL:0008011
name: skeletal muscle satellite stem cell
namespace: cell
def: "A skeletal muscle satellite cell that divides by stem cell division.  A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." [PMID:23303905]
is_a: CL:0000035 ! single fate stem cell
is_a: CL:0000594 ! skeletal muscle satellite cell
intersection_of: CL:0000594 ! skeletal muscle satellite cell
intersection_of: bearer_of PATO:0001400 ! unipotent
intersection_of: capable_of GO:0017145 ! stem cell division
disjoint_from: CL:0008020 ! skeletal muscle satellite myogenic cell
relationship: bearer_of PATO:0001400 ! unipotent
relationship: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0008012
name: quiescent skeletal muscle satellite cell
namespace: cell
def: "A skeletal muscle satellite cell that is mitotically quiescent.  These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." [PMID:21849021, PMID:23303905]
is_a: CL:0000594 ! skeletal muscle satellite cell

[Term]
id: CL:0008013
name: cranial visceromotor neuron
def: " A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." [PMID:14699587]
is_a: CL:0005025 ! visceromotor neuron
is_a: CL:0015000 ! cranial motor neuron
relationship: has_soma_location UBERON:0002028 ! hindbrain

[Term]
id: CL:0008014
name: excitatory motor neuron
def: "A motor neuron that is capable of directly inducing muscle contraction." []
comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates.
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0008015
name: inhibitory motor neuron
def: "A motor neuron that is capable of directly inhibiting muscle contraction." []
comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates.
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0008016
name: activated skeletal muscle satellite cell
namespace: cell
def: "A skeletal muscle cell that has become mitotically active - typically following muscle damage." [PMID:21849021, PMID:23303905]
is_a: CL:0000594 ! skeletal muscle satellite cell
relationship: develops_from CL:0008012 {comment="More accurately - transformation_of ?"} ! quiescent skeletal muscle satellite cell

[Term]
id: CL:0008017
name: adult skeletal muscle myoblast
namespace: cell
def: "A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905]
comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.
synonym: "myogenic precursor cell" BROAD [PMID:23303905]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: develops_into CL:0008002 ! skeletal muscle fiber
relationship: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0008018
name: somatic muscle myoblast
namespace: cell
def: "A myoblast that is commited to developing into a somatic muscle." []
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008003 ! somatic muscle myotube
relationship: develops_into CL:0008003 ! somatic muscle myotube

[Term]
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
is_a: CL:0002371 ! somatic cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme

[Term]
id: CL:0008020
name: skeletal muscle satellite myogenic cell
namespace: cell
def: "A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts." [GOC:dos, PMID:23303905]
is_a: CL:0000594 ! skeletal muscle satellite cell
relationship: develops_into CL:0008017 ! adult skeletal muscle myoblast

[Term]
id: CL:0008021
name: anterior lateral line ganglion neuron
is_a: CL:2000031 ! lateral line ganglion neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:2001391 ! anterior lateral line ganglion
relationship: part_of UBERON:2001391 ! anterior lateral line ganglion

[Term]
id: CL:0008022
name: endocardial cushion cell
def: "A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000569 ! cardiac mesenchymal cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000569 ! cardiac mesenchymal cell
intersection_of: part_of UBERON:0002062 ! endocardial cushion
relationship: part_of UBERON:0002062 ! endocardial cushion

[Term]
id: CL:0008023
name: cardiac fibroblast
comment: Duplicate term.
is_obsolete: true
replaced_by: CL:0002548

[Term]
id: CL:0008024
name: pancreatic endocrine cell
namespace: cell
def: "An endocrine cell that is part of the pancreas." [GOC:dos]
is_a: CL:0000163 ! endocrine cell
intersection_of: CL:0000163 ! endocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0008025
name: noradrenergic neuron
def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos]
is_a: CL:0000459 ! noradrenergic cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission

[Term]
id: CL:0008026
name: open tracheal system tracheocyte
namespace: cell
def: "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." [GOC:dos]
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003127 ! open tracheal system trachea
relationship: part_of UBERON:0003127 ! open tracheal system trachea

[Term]
id: CL:0009000
name: sensory neuron of spinal nerve
def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr]
synonym: "spinal sensory neuron" EXACT []
is_a: CL:0000101 {is_inferred="true"} ! sensory neuron
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: part_of UBERON:0001780 ! spinal nerve
relationship: part_of UBERON:0001780 ! spinal nerve

[Term]
id: CL:0009001
name: compound eye retinal cell
def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." []
xref: GOC:pr
xref: PMID:12021768
is_a: CL:0009004 ! retinal cell

[Term]
id: CL:0009002
name: inflammatory cell
def: "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." []
xref: GOC:pr
xref: http://en.wikipedia.org/wiki/Inflammatory_response
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0009003
name: larval midgut cell
def: "Any cell in the midgut (middle subdivision of a digestive tract) of a larva." []
xref: GOC:pr
xref: http://en.wikipedia.org/wiki/Insect#Midgut
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0009004
name: retinal cell
namespace: cell
def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr]
xref: PMID:10702418
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002319 ! neural cell
intersection_of: part_of UBERON:0005388 ! photoreceptor array
relationship: part_of UBERON:0005388 ! photoreceptor array

[Term]
id: CL:0009005
name: salivary gland cell
def: "Any cell in a salivary gland." []
xref: GOC:pr
xref: http://en.wikipedia.org/wiki/Salivary_gland
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0010000
name: keratinized cell of hair follicle
def: "A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath." [https://github.com/obophenotype/cell-ontology/issues/417]
is_a: CL:2000092 ! hair follicular keratinocyte
relationship: part_of UBERON:0005933 ! hair root sheath

[Term]
id: CL:0010001
name: stromal cell of bone marrow
def: "a stromal cell that is part_of a bone marrow" []
synonym: "bone marrow stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: GOC:cjm

[Term]
id: CL:0010002
name: epithelial cell of umbilical artery
def: "a epithelial cell that is part_of a umbilical artery" []
synonym: "umbilical artery epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: part_of UBERON:0001310 ! umbilical artery
created_by: GOC:cjm

[Term]
id: CL:0010003
name: epithelial cell of alveolus of lung
def: "a epithelial cell that is part_of a alveolus of lung" []
comment: May be merged with pneumocyte in future
synonym: "alveolus of lung epithelial cell" EXACT []
is_a: CL:0000082 ! epithelial cell of lung
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0002299 ! alveolus of lung
created_by: GOC:cjm

[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
def: "a mononuclear cell that is part_of a bone marrow" []
synonym: "bone marrow mononuclear cell" EXACT []
is_a: CL:0000842 ! mononuclear cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
created_by: GOC:cjm

[Term]
id: CL:0010005
name: atrioventricular bundle cell
def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell" EXACT []
is_a: CL:0010007 ! His-Purkinje system cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0002353 ! atrioventricular bundle
relationship: part_of UBERON:0002353 ! atrioventricular bundle

[Term]
id: CL:0010006
name: cardiac blood vessel endothelial cell
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:0010007
name: His-Purkinje system cell
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0004146 ! His-Purkinje system
relationship: part_of UBERON:0004146 ! His-Purkinje system

[Term]
id: CL:0010008
name: cardiac endothelial cell
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:0010009
name: camera-type eye photoreceptor cell
synonym: "camera type eye photoreceptor cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000966 {editor="GOC:cjm"} ! retina

[Term]
id: CL:0010010
name: cerebellar stellate cell
is_a: CL:0000122 ! stellate neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: CL:0010011
name: cerebral cortex GABAergic interneuron
def: "a GABAergic interneuron that is part_of a cerebral cortex" []
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0002609 ! neuron of cerebral cortex
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: CL:0010012
name: cerebral cortex neuron
def: "a neuron that is part_of a cerebral cortex" []
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: CL:0010013
name: type I pinealocyte
synonym: "light pinealocyte" EXACT []
is_a: CL:0000652 ! pinealocyte

[Term]
id: CL:0010014
name: type II pinealocyte
synonym: "dark pinealocyte" EXACT []
is_a: CL:0000652 ! pinealocyte

[Term]
id: CL:0010015
name: coronet cell
def: "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." [GOC:mr, PMID:17595538]
comment: Editor note: remember to link to Saccus vasculosus in next uberon release
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0010016
name: collar cell
namespace: cell
def: "A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." [PMID:25840473]
is_a: CL:0000548 ! animal cell
relationship: has_part GO:0005929 ! cilium

[Term]
id: CL:0010020
name: cardiac glial cell
is_a: CL:0000125 ! glial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:0010021
name: cardiac myoblast
namespace: cell
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
relationship: develops_into CL:0000746 ! cardiac muscle cell

[Term]
id: CL:0010022
name: cardiac neuron
is_a: CL:0000540 ! neuron
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:0011000
name: dorsal horn interneuron
def: "A CNS interneuron located in the dorsal horn of the spinal cord." [GOC:nv]
synonym: "dorsal spinal cord interneuron" RELATED []
is_a: CL:0002611 ! neuron of the dorsal spinal cord
is_a: CL:0005000 {is_inferred="true"} ! spinal cord interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord
relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord

[Term]
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv]
is_a: CL:0000100 {is_inferred="true"} ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: CL:0011002
name: lateral motor column neuron
def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [GOC:nv]
comment: Need to MIREOT in 'spinal cord lateral column' from Uberon
is_a: CL:0011001 ! spinal cord motor neuron

[Term]
id: CL:0011003
name: magnocellular neurosecretory cell (duplicate class)
def: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin." [GOC:nv, MP:0009467]
synonym: "magnocellular neuron" EXACT []
is_a: CL:0000381 ! neurosecretory neuron
is_a: CL:2000029 ! central nervous system neuron
is_a: CL:2000030 ! hypothalamus native cell
relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus
relationship: part_of UBERON:0006568 ! hypothalamic nucleus

[Term]
id: CL:0011004
name: lens fiber cell
def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GO:0070307, GOC:nv]
synonym: "lens fibre cell" EXACT []
is_a: CL:0002222 ! vertebrate lens cell

[Term]
id: CL:0011005
name: GABAergic interneuron
def: "An interneuron that uses GABA as a vesicular neurotransmitter." [GOC:nv]
is_a: CL:0000099 ! interneuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: CL:0000617 ! GABAergic neuron

[Term]
id: CL:0011006
name: Lugaro cell
def: "An inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:nv]
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: CL:0011007
name: paraxial cell
def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492]
synonym: "paraxial mesoderm cell" EXACT []
synonym: "presomitic mesoderm cell" NARROW []
synonym: "somitic mesoderm cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
intersection_of: CL:0000222 ! mesodermal cell
intersection_of: part_of UBERON:0003059 ! presomitic mesoderm
relationship: part_of UBERON:0003059 ! presomitic mesoderm

[Term]
id: CL:0011008
name: embryonic hemocyte
def: "A hemocyte derived from head mesoderm, which enters the hemolymph as acirculating cell." [GOC:NV, PMID:17967061]
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0011009
name: embryonic plasmatocyte
def: "A plasmatocyte derived from head mesoderm." [GOC:NV, PMID:17967061]
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0011010
name: lateral mesodermal cell
def: "A cell derived from the mesoderm that is found at the periphery of the embryo." [GOC:NV, PMID:9169844]
is_a: CL:0000222 ! mesodermal cell

[Term]
id: CL:0011011
name: intermediate mesodermal cell
def: "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate." [GOC:NV, ISBN:978-0-87969-707-5]
is_a: CL:0000222 ! mesodermal cell

[Term]
id: CL:0011012
name: neural crest cell
namespace: cell
def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880]
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002321 ! embryonic cell

[Term]
id: CL:0011100
name: galanergic neuron
def: "Neuron that secretes the neurotransmitter galanin." [GOC:NV, PMID:23159249, ZFIN:CVS, ZFIN:YB]
is_a: CL:0000540 ! neuron

[Term]
id: CL:0011101
name: chorionic trophoblast cell
def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV]
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: part_of UBERON:0003124 ! chorion
relationship: part_of UBERON:0003124 ! chorion

[Term]
id: CL:0011102
name: parasympathetic neuron
def: "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." [GOC:NV, isbn:0080923437]
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0011103
name: sympathetic neuron
def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [GOC:NV, isbn:0080923437]
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0011104
name: interplexiform cell
def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer." [GOC:NV, PMID:12771169]
comment: Need to MIREOT retinal inner nuclear layer (part of)
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0001791 ! inner nuclear layer of retina

[Term]
id: CL:0011105
name: dopamanergic interplexiform cell
def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer, using dopamine. " [GOC:NV, PMID:12771169]
comment: This type of cell is found in Danio rerio.
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:0011104 ! interplexiform cell
intersection_of: CL:0011104 ! interplexiform cell
intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission
relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission

[Term]
id: CL:0011106
name: GABAnergic interplexiform cell
def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer using GABA. " [GOC:NV, PMID:12771169]
comment: This type of cell is found in many mammals.
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:0011104 ! interplexiform cell
intersection_of: CL:0011104 ! interplexiform cell
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:0011107
name: Muller cell
def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.\n" [GOC:NV, PMID:21911394]
synonym: "Muller glia " EXACT []
synonym: "Müller cell" EXACT []
is_a: CL:0000681 ! radial glial cell
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0000966 ! retina

[Term]
id: CL:0011108
name: colon epithelial cell
def: "Epithelial cell that is part of the colon epithelium. " [GOC:NV]
synonym: "colonic epithelial cell" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0000397 ! colonic epithelium
relationship: part_of UBERON:0001155 ! colon

[Term]
id: CL:0011109
name: hypocretin-secreting neuron
def: "A neuron that releases hypocretin as a neurotransmitter." [GOC:NV, PMID:23848055]
synonym: "orexin" EXACT []
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061585 ! hypocretin secretion, neurotransmission
relationship: capable_of GO:0061585 ! hypocretin secretion, neurotransmission

[Term]
id: CL:0011110
name: histaminergic neuron
def: "Neuron that secretes histamine." [GOC:NV, PMID:22677810]
is_a: CL:0000540 ! neuron
is_a: CL:0002274 ! histamine secreting cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061538 ! histamine secretion, neurotransmission
relationship: capable_of GO:0061538 ! histamine secretion, neurotransmission

[Term]
id: CL:0011111
name: gonadotropin releasing neuron
def: "Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction." [GOC:NV, PMID:21828096]
synonym: "GnRH neuron" EXACT []
synonym: "GnRH-secreting neuron" EXACT []
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000381 ! neurosecretory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0032274 ! gonadotropin secretion
relationship: capable_of GO:0032274 ! gonadotropin secretion

[Term]
id: CL:0011112
name: magnocellular neurosecretory cell
def: "Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." [GOC:NV, PMID:10711808]
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000381 ! neurosecretory neuron

[Term]
id: CL:0011113
name: spiral ganglion neuron
def: "Neuron found in the spriral ganglion." [GOC:NV]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0000395 ! cochlear ganglion
relationship: part_of UBERON:0000395 ! cochlear ganglion

[Term]
id: CL:0011114
name: segmented neutrophil of bone marrow
def: "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." [PMID:11138622, PMID:15514007]
is_a: CL:0000096 ! mature neutrophil
is_a: CL:1001610 ! bone marrow hematopoietic cell
relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M
relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III
relationship: part_of UBERON:0002371 ! bone marrow

[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos]
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. 
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: capable_of GO:0030154 ! cell differentiation
relationship: capable_of GO:0030154 ! cell differentiation

[Term]
id: CL:0012000
name: astrocyte of the forebrain
namespace: cell
def: "An astrocyte of the forebrain." []
synonym: "forebrain astrocyte" EXACT []
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain
created_by: tberardini

[Term]
id: CL:0012001
name: neuron of the forebrain
namespace: cell
def: "A CNS neuron of the forebrain." []
synonym: "forebrain neuron" EXACT []
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain
created_by: tberardini

[Term]
id: CL:0013000
name: forebrain radial glial cell
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: CL:0015000
name: cranial motor neuron
def: "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. " [ZFIN:CVS\n]
synonym: "cranial motoneuron" EXACT []
xref: PMID:14699587 \n
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:1000001
name: retrotrapezoid nucleus neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0009918 ! retrotrapezoid nucleus
relationship: part_of UBERON:0009918 ! retrotrapezoid nucleus

[Term]
id: CL:1000022
name: mesonephric nephron tubule epithelial cell
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005329 ! mesonephric nephron tubule
relationship: part_of UBERON:0005329 ! mesonephric nephron tubule

[Term]
id: CL:1000042
name: forebrain neuroblast
is_a: CL:0000031 ! neuroblast
intersection_of: CL:0000031 ! neuroblast
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: CL:1000050
name: lateral line nerve glial cell
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0008906 ! lateral line nerve
relationship: part_of UBERON:0008906 ! lateral line nerve

[Term]
id: CL:1000073
name: spinal cord radial glial cell
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: CL:1000082
name: stretch receptor cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell

[Term]
id: CL:1000083
name: stratified keratinized epithelial stem cell
namespace: cell
is_a: CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:1000085
name: stratified non keratinized epithelial stem cell
namespace: cell
is_a: CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:1000090
name: pronephric nephron tubule epithelial cell
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule
relationship: part_of UBERON:0005310 ! pronephric nephron tubule

[Term]
id: CL:1000123
name: metanephric nephron tubule epithelial cell
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule
relationship: part_of UBERON:0005146 ! metanephric nephron tubule

[Term]
id: CL:1000143
name: lung goblet cell
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002370 ! respiratory goblet cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1000147
name: heart valve cell
is_a: CL:0000663 ! valve cell
intersection_of: CL:0000663 ! valve cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:1000155
name: Malpighian tubule stellate cell
def: "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GO:0061330]
synonym: "Malpighian tubule Type II cell" EXACT [FBbt:00005797]
xref: FBbt:00005797
is_a: CL:0000151 ! secretory cell
relationship: part_of UBERON:0001054 ! Malpighian tubule

[Term]
id: CL:1000182
name: malpighian tubule tip cell
is_a: CL:0000423 ! tip cell
intersection_of: CL:0000423 ! tip cell
intersection_of: part_of UBERON:0001054 ! Malpighian tubule
relationship: part_of UBERON:0001054 ! Malpighian tubule

[Term]
id: CL:1000191
name: pillar cell
namespace: cell
def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662]
synonym: "cochlear pillar cell" RELATED []
synonym: "pillar cell of cochlea" EXACT []
synonym: "pillar cell of corti" EXACT []
synonym: "rod cell of Corti" EXACT []
xref: FMA:75722
is_a: CL:0002490 ! organ of Corti supporting cell

[Term]
id: CL:1000217
name: growth plate cartilage chondrocyte
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0004129 ! growth plate cartilage
relationship: part_of UBERON:0004129 ! growth plate cartilage

[Term]
id: CL:1000222
name: stomach neuroendocrine cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: CL:1000223
name: lung neuroendocrine cell
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1000236
name: posterior lateral line nerve glial cell
is_a: CL:1000050 ! lateral line nerve glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:2000175 ! posterior lateral line nerve
relationship: part_of UBERON:2000175 ! posterior lateral line nerve

[Term]
id: CL:1000239
name: anterior lateral line nerve glial cell
is_a: CL:1000050 ! lateral line nerve glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:2000425 ! anterior lateral line nerve
relationship: part_of UBERON:2000425 ! anterior lateral line nerve

[Term]
id: CL:1000245
name: posterior lateral line ganglion neuron
is_a: CL:2000031 ! lateral line ganglion neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:2001314 ! posterior lateral line ganglion
relationship: part_of UBERON:2001314 ! posterior lateral line ganglion

[Term]
id: CL:1000271
name: lung ciliated cell
is_a: CL:0000064 ! ciliated cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1000272
name: lung secretory cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1000274
name: trophectodermal cell
namespace: cell
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell

[Term]
id: CL:1000275
name: smooth muscle cell of small intestine
namespace: cell
def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm]
synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050]
xref: FMA:15050
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: CL:1000276
name: smooth muscle fiber of duodenum
namespace: cell
def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm]
synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058]
xref: FMA:15058
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: CL:1000277
name: smooth muscle fiber of jejunum
namespace: cell
def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm]
synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062]
xref: FMA:15062
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: CL:1000278
name: smooth muscle fiber of ileum
namespace: cell
def: "A smooth muscle cell that is part of the ileum." [GOC:tfm]
synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066]
xref: FMA:15066
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: CL:1000279
name: smooth muscle cell of large intestine
namespace: cell
def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm]
synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653]
xref: FMA:15653
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine

[Term]
id: CL:1000280
name: smooth muscle cell of colon
namespace: cell
def: "A smooth muscle cell that is part of the colon." [GOC:tfm]
synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663]
xref: FMA:15663
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: CL:1000281
name: smooth muscle cell of cecum
namespace: cell
def: "A smooth muscle cell that is part of the cecum." [GOC:tfm]
synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681]
synonym: "smooth muscle fiber of cecum" EXACT []
xref: FMA:15681
is_a: CL:1000280 ! smooth muscle cell of colon
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: CL:1000282
name: smooth muscle fiber of ascending colon
namespace: cell
def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm]
synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518]
xref: FMA:17518
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001156 ! ascending colon
relationship: part_of UBERON:0001156 ! ascending colon

[Term]
id: CL:1000283
name: smooth muscle fiber of transverse colon
namespace: cell
def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm]
synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519]
xref: FMA:17519
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001157 ! transverse colon
relationship: part_of UBERON:0001157 ! transverse colon

[Term]
id: CL:1000284
name: smooth muscle fiber of descending colon
namespace: cell
def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm]
synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520]
xref: FMA:17520
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001158 ! descending colon
relationship: part_of UBERON:0001158 ! descending colon

[Term]
id: CL:1000285
name: smooth muscle cell of sigmoid colon
namespace: cell
def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm]
synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521]
xref: FMA:17521
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon

[Term]
id: CL:1000286
name: smooth muscle cell of rectum
namespace: cell
def: "A smooth muscle cell that is part of the rectum." [GOC:tfm]
synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522]
synonym: "smooth muscle fiber of rectum" EXACT []
xref: FMA:17522
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: CL:1000287
name: myocyte of anterior internodal tract
namespace: cell
def: "A muscle cell that is part of the anterior internodal tract." [GOC:tfm]
xref: FMA:223276
is_a: CL:0002096 ! internodal tract myocyte

[Term]
id: CL:1000288
name: myocyte of atrial branch of anterior internodal tract
namespace: cell
def: "A muscle cell that is part of the atrial branch of anterior internodal tract." [GOC:tfm]
xref: FMA:223277
is_a: CL:0002096 ! internodal tract myocyte

[Term]
id: CL:1000289
name: myocyte of atrial septal branch of anterior internodal tract
namespace: cell
def: "A muscle cell that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm]
xref: FMA:223278
is_a: CL:0002096 ! internodal tract myocyte

[Term]
id: CL:1000290
name: myocyte of middle internodal tract
namespace: cell
def: "A muscle cell that is part of the middle internodal tract." [GOC:tfm]
xref: FMA:223279
is_a: CL:0002096 ! internodal tract myocyte

[Term]
id: CL:1000291
name: myocyte of posterior internodal tract
namespace: cell
def: "A muscle cell that is part of the posterior internodal tract." [GOC:tfm]
xref: FMA:223280
is_a: CL:0002096 ! internodal tract myocyte

[Term]
id: CL:1000296
name: epithelial cell of urethra
namespace: cell
def: "An epithelial cell that is part of the urethra." [GOC:tfm]
xref: FMA:256165
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
is_a: CL:1001320 ! urethra cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: CL:1000298
name: mesothelial cell of dura mater
namespace: cell
def: "A mesothelial cell that is part of the dura mater." [GOC:tfm]
synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516]
xref: FMA:256516
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002363 ! dura mater
relationship: part_of UBERON:0002363 ! dura mater

[Term]
id: CL:1000299
name: fibroblast of connective tissue of prostate
namespace: cell
def: "A fibroblast that is part of the connective tissue of prostate." [GOC:tfm]
xref: FMA:261271
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000300
name: fibroblast of outer membrane of prostatic capsule
namespace: cell
def: "A fibroblast that is part of the outer membrane of prostatic capsule." [GOC:tfm]
xref: FMA:261273
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000301
name: fibroblast of subepithelial connective tissue of prostatic gland
namespace: cell
def: "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." [GOC:tfm]
xref: FMA:261275
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000302
name: fibroblast of papillary layer of dermis
namespace: cell
def: "A fibroblast that is part of the papillary layer of dermis." [GOC:tfm]
xref: FMA:261277
is_a: CL:0002551 {is_inferred="true"} ! fibroblast of dermis
intersection_of: CL:0002551 ! fibroblast of dermis
intersection_of: part_of UBERON:0001992 ! papillary layer of dermis
relationship: part_of UBERON:0001992 ! papillary layer of dermis

[Term]
id: CL:1000303
name: fibroblast of areolar connective tissue
namespace: cell
def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm]
xref: FMA:261279
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0006815 ! areolar connective tissue
relationship: part_of UBERON:0006815 ! areolar connective tissue

[Term]
id: CL:1000304
name: fibroblast of connective tissue of nonglandular part of prostate
namespace: cell
def: "A fibroblast that is part of the connective tissue of nonglandular part of prostate." [GOC:tfm]
xref: FMA:261281
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000305
name: fibroblast of connective tissue of glandular part of prostate
namespace: cell
def: "A fibroblast that is part of the connective tissue of glandular part of prostate." [GOC:tfm]
xref: FMA:261283
is_a: CL:0000057 ! fibroblast
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000306
name: fibroblast of tunica adventitia of artery
namespace: cell
def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm]
xref: FMA:261285
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002503 ! adventitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel
relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel

[Term]
id: CL:1000307
name: fibroblast of dense regular elastic tissue
namespace: cell
def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm]
xref: FMA:261287
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0007846 ! dense regular connective tissue
relationship: part_of UBERON:0002521 ! elastic tissue
relationship: part_of UBERON:0007846 ! dense regular connective tissue

[Term]
id: CL:1000308
name: fibrocyte of adventitia of ureter
namespace: cell
def: "A fibrocyte that is part of the adventitia of ureter." [GOC:tfm]
xref: FMA:261289
is_a: CL:0000135 {is_inferred="true"} ! fibrocyte
is_a: CL:1000708 ! ureter adventitial cell
intersection_of: CL:0000135 ! fibrocyte
intersection_of: part_of UBERON:0001252 ! adventitia of ureter
relationship: part_of UBERON:0001252 ! adventitia of ureter

[Term]
id: CL:1000309
name: epicardial adipocyte
namespace: cell
def: "A fat cell that is part of the epicardial fat." [GOC:tfm]
synonym: "adipocyte of epicardial fat" EXACT [FMA:261293]
synonym: "epicardial fat cell" EXACT [FMA:261293]
xref: FMA:261293
is_a: CL:0000136 ! fat cell
is_a: CL:0002494 ! cardiocyte
relationship: part_of UBERON:0002348 ! epicardium

[Term]
id: CL:1000310
name: adipocyte of epicardial fat of right ventricle
namespace: cell
def: "A fat cell that is part of the epicardial fat of right ventricle." [GOC:tfm]
synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297]
synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297]
xref: FMA:261297
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: CL:1000311
name: adipocyte of epicardial fat of left ventricle
namespace: cell
def: "A fat cell that is part of the epicardial fat of left ventricle." [GOC:tfm]
synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300]
synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300]
xref: FMA:261300
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: CL:1000312
name: bronchial goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm]
synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032]
xref: FMA:263032
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:0002370 ! respiratory goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: CL:1000313
name: gastric goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm]
synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035]
xref: FMA:263035
is_a: CL:0000160 ! goblet cell
is_a: CL:0002180 ! mucous cell of stomach
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0001276 ! epithelium of stomach

[Term]
id: CL:1000314
name: gastric cardiac gland goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm]
synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT []
xref: FMA:263038
is_a: CL:0000152 ! exocrine cell
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008859 ! cardiac gastric gland
relationship: part_of UBERON:0008859 ! cardiac gastric gland

[Term]
id: CL:1000315
name: principal gastric gland goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of principal gastric gland." [GOC:tfm]
synonym: "goblet cell of epithelium of principal gastric gland" EXACT []
xref: FMA:263040
is_a: CL:0000152 ! exocrine cell
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0009971 ! principal gastric gland
relationship: part_of UBERON:0009971 ! principal gastric gland

[Term]
id: CL:1000316
name: obsolete goblet cell of epithelium of small intestine
namespace: cell
def: "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." [GOC:tfm]
xref: FMA:263042
is_obsolete: true
replaced_by: CL:1000495

[Term]
id: CL:1000317
name: intestinal villus goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:tfm]
synonym: "goblet cell of epithelium of intestinal villus" EXACT []
xref: FMA:263046
is_a: CL:1000495 ! small intestine goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0013636 ! epithelium of intestinal villus

[Term]
id: CL:1000318
name: obsolete small intestine crypt goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm]
xref: FMA:263050
is_obsolete: true

[Term]
id: CL:1000319
name: obsolete goblet cell of epithelium proper of small intestine
namespace: cell
def: "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." [GOC:tfm]
xref: FMA:263052
is_obsolete: true

[Term]
id: CL:1000320
name: large intestine goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of large intestine." [GOC:tfm]
synonym: "goblet cell of epithelium of large intestine" EXACT []
xref: FMA:263054
is_a: CL:0000160 ! goblet cell
is_a: CL:0002658 ! glandular cell of the large intestine
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001278 ! epithelium of large intestine

[Term]
id: CL:1000321
name: large intestine crypt goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine." [GOC:tfm]
xref: FMA:263056
is_a: CL:1000320 ! large intestine goblet cell

[Term]
id: CL:1000322
name: pancreatic goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm]
synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058]
xref: FMA:263058
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0000160 ! goblet cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct

[Term]
id: CL:1000323
name: pylroric gastric gland goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm]
synonym: "goblet cell of epithelium of pyloric gland" EXACT []
xref: FMA:263061
is_a: CL:0000152 ! exocrine cell
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008861 ! pyloric gastric gland
relationship: part_of UBERON:0008861 ! pyloric gastric gland

[Term]
id: CL:1000324
name: duodenal goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium proper of duodenum." [GOC:tfm]
synonym: "goblet cell of epithelium proper of duodenum" EXACT []
xref: FMA:263063
is_a: CL:1000317 ! intestinal villus goblet cell
is_a: CL:1001589 ! duodenum glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008346 ! duodenal epithelium

[Term]
id: CL:1000325
name: jejunal goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm]
synonym: "goblet cell of epithelium proper of jejunum" EXACT []
xref: FMA:263065
is_a: CL:1000317 ! intestinal villus goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: CL:1000326
name: ileal goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm]
synonym: "goblet cell of epithelium proper of ileum" EXACT []
xref: FMA:263067
is_a: CL:1000317 ! intestinal villus goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: CL:1000327
name: appendix goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm]
synonym: "goblet cell of epithelium proper of appendix" EXACT []
xref: FMA:263069
is_a: CL:1000320 ! large intestine goblet cell
is_a: CL:1001585 ! appendix glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: CL:1000328
name: obsolete goblet cell of epithelium proper of large intestine
namespace: cell
def: "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." [GOC:tfm]
xref: FMA:263071
is_obsolete: true

[Term]
id: CL:1000329
name: tracheal goblet cell
namespace: cell
def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm]
synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075]
xref: FMA:263075
is_a: CL:0000307 ! tracheal epithelial cell
is_a: CL:0002370 ! respiratory goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: CL:1000330
name: serous cell of epithelium of trachea
namespace: cell
def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm]
xref: FMA:263078
is_a: CL:0000313 {is_inferred="true"} ! serous secreting cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea

[Term]
id: CL:1000331
name: serous cell of epithelium of bronchus
namespace: cell
def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm]
xref: FMA:263080
is_a: CL:0000313 ! serous secreting cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus

[Term]
id: CL:1000332
name: serous cell of epithelium of terminal bronchiole
namespace: cell
def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm]
xref: FMA:263082
is_a: CL:1000333 ! serous cell of epithelium of lobular bronchiole
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium

[Term]
id: CL:1000333
name: serous cell of epithelium of lobular bronchiole
namespace: cell
def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm]
xref: FMA:263084
is_a: CL:1000272 ! lung secretory cell
is_a: CL:1000331 ! serous cell of epithelium of bronchus
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole
relationship: part_of UBERON:0002051 ! epithelium of bronchiole

[Term]
id: CL:1000334
name: enterocyte of epithelium of small intestine
namespace: cell
def: "An enterocyte that is part of the epithelium of small intestine." [GOC:tfm]
xref: FMA:263086
is_a: CL:0000584 {is_inferred="true"} ! enterocyte
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine

[Term]
id: CL:1000335
name: enterocyte of epithelium of intestinal villus
namespace: cell
def: "An enterocyte that is part of the epithelium of intestinal villus." [GOC:tfm]
xref: FMA:263088
is_a: CL:1000334 ! enterocyte of epithelium of small intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: part_of UBERON:0013636 ! epithelium of intestinal villus
relationship: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0013636 ! epithelium of intestinal villus

[Term]
id: CL:1000337
name: enterocyte of epithelium of duodenal gland
namespace: cell
def: "An enterocyte that is part of the epithelium of duodenal gland." [GOC:tfm]
xref: FMA:263092
is_a: CL:0000584 ! enterocyte
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000584 ! enterocyte
intersection_of: part_of UBERON:0001212 ! duodenal gland
relationship: part_of UBERON:0001212 ! duodenal gland

[Term]
id: CL:1000338
name: enterocyte of epithelium of crypt of Lieberkuhn of small intestine
namespace: cell
def: "An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm]
xref: FMA:263094
is_a: CL:1000334 ! enterocyte of epithelium of small intestine
relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn

[Term]
id: CL:1000339
name: enterocyte of epithelium proper of small intestine
namespace: cell
def: "An enterocyte that is part of the epithelium proper of small intestine." [GOC:tfm]
xref: FMA:263096
is_a: CL:1000334 ! enterocyte of epithelium of small intestine

[Term]
id: CL:1000340
name: enterocyte of epithelium proper of duodenum
namespace: cell
def: "An enterocyte that is part of the epithelium proper of duodenum." [GOC:tfm]
xref: FMA:263098
is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: CL:1000341
name: enterocyte of epithelium proper of jejunum
namespace: cell
def: "An enterocyte that is part of the epithelium proper of jejunum." [GOC:tfm]
xref: FMA:263100
is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine

[Term]
id: CL:1000342
name: enterocyte of epithelium proper of ileum
namespace: cell
def: "An enterocyte that is part of the epithelium proper of ileum." [GOC:tfm]
xref: FMA:263102
is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine

[Term]
id: CL:1000343
name: paneth cell of epithelium of small intestine
namespace: cell
def: "A paneth cell that is part of the epithelium of small intestine." [GOC:tfm]
xref: FMA:263104
is_a: CL:0000510 {is_inferred="true"} ! paneth cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000510 ! paneth cell
intersection_of: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine

[Term]
id: CL:1000344
name: paneth cell of epithelium proper of small intestine
namespace: cell
def: "A Paneth cell that is part of the epithelium proper of small intestine." [GOC:tfm]
xref: FMA:263106
is_a: CL:1000343 ! paneth cell of epithelium of small intestine

[Term]
id: CL:1000345
name: paneth cell of epithelium of crypt of Lieberkuhn of small intestine
namespace: cell
def: "A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm]
xref: FMA:263108
is_a: CL:1000343 ! paneth cell of epithelium of small intestine
relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn

[Term]
id: CL:1000346
name: vacuolar absorptive cell of epithelium proper of large intestine
namespace: cell
alt_id: CL:1000336
def: "MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine." [GOC:tfm]
synonym: "enterocyte of epithelium proper of large intestine" EXACT []
xref: FMA:263090
xref: FMA:263112
is_a: CL:0002071 ! enterocyte of epithelium of large intestine

[Term]
id: CL:1000347
name: vacuolar absorptive cell of epithelium of colon
namespace: cell
def: "A columnar cell of the colon that is part of the colonic epithelium." [GOC:tfm]
xref: FMA:263114
is_a: CL:0002071 {is_inferred="true"} ! enterocyte of epithelium of large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine
intersection_of: part_of UBERON:0000397 ! colonic epithelium
relationship: part_of UBERON:0000397 ! colonic epithelium

[Term]
id: CL:1000348
name: basal cell of epithelium of trachea
namespace: cell
def: "A basal cell that is part of the epithelium of trachea." [GOC:tfm]
xref: FMA:263118
is_a: CL:0000307 ! tracheal epithelial cell
is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea

[Term]
id: CL:1000349
name: basal cell of epithelium of bronchus
namespace: cell
alt_id: CL:0002331
def: "A basal cell found in the bronchus epithelium." [GOC:tfm]
synonym: "basal cell of bronchus" EXACT []
xref: FMA:263120
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree
is_a: CL:0002633 ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus

[Term]
id: CL:1000350
name: basal cell of epithelium of terminal bronchiole
namespace: cell
def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm]
xref: FMA:263122
is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium

[Term]
id: CL:1000351
name: basal cell of epithelium of respiratory bronchiole
namespace: cell
def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm]
xref: FMA:263124
is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole
relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole

[Term]
id: CL:1000352
name: basal cell of epithelium of lobular bronchiole
namespace: cell
def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm]
xref: FMA:263126
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:1000349 ! basal cell of epithelium of bronchus
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole
relationship: part_of UBERON:0002051 ! epithelium of bronchiole

[Term]
id: CL:1000353
name: microfold cell of epithelium of small intestine
namespace: cell
def: "A M cell that is part of the epithelium of small intestine." [GOC:tfm]
xref: FMA:263128
is_a: CL:0000682 {is_inferred="true"} ! M cell of gut
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: CL:1000354
name: microfold cell of epithelium of intestinal villus
namespace: cell
def: "A M cell that is part of the epithelium of intestinal villus." [GOC:tfm]
xref: FMA:263130
is_a: CL:1000353 ! microfold cell of epithelium of small intestine
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0013636 ! epithelium of intestinal villus

[Term]
id: CL:1000355
name: microfold cell of epithelium proper of small intestine
namespace: cell
def: "A M cell that is part of the epithelium proper of small intestine." [GOC:tfm]
xref: FMA:263132
is_a: CL:1000353 ! microfold cell of epithelium of small intestine

[Term]
id: CL:1000356
name: microfold cell of epithelium proper of duodenum
namespace: cell
def: "A M cell that is part of the epithelium proper of duodenum." [GOC:tfm]
xref: FMA:263134
is_a: CL:1000354 ! microfold cell of epithelium of intestinal villus
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008346 ! duodenal epithelium

[Term]
id: CL:1000357
name: microfold cell of epithelium proper of jejunum
namespace: cell
def: "A M cell that is part of the epithelium proper of jejunum." [GOC:tfm]
xref: FMA:263136
is_a: CL:1000353 ! microfold cell of epithelium of small intestine
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: CL:1000358
name: microfold cell of epithelium proper of ileum
namespace: cell
def: "A M cell that is part of the epithelium proper of ileum." [GOC:tfm]
xref: FMA:263138
is_a: CL:1000353 ! microfold cell of epithelium of small intestine
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: CL:1000359
name: microfold cell of epithelium proper of appendix
namespace: cell
def: "A M cell that is part of the epithelium proper of appendix." [GOC:tfm]
xref: FMA:263140
is_a: CL:1000360 ! microfold cell of epithelium proper of large intestine
is_a: CL:1000405 ! epithelial cell of appendix
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0009697 ! epithelium of appendix
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: CL:1000360
name: microfold cell of epithelium proper of large intestine
namespace: cell
def: "A M cell that is part of the epithelium proper of large intestine." [GOC:tfm]
xref: FMA:263142
is_a: CL:0000682 ! M cell of gut
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000682 ! M cell of gut
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine

[Term]
id: CL:1000361
name: transitional myocyte of interatrial septum
namespace: cell
def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm]
xref: FMA:263152
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum native cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002085 ! interatrial septum
relationship: part_of UBERON:0002085 ! interatrial septum

[Term]
id: CL:1000362
name: transitional myocyte of interventricular septum
namespace: cell
def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263154
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum native cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000363
name: transitional myocyte of atrial branch of anterior internodal tract
namespace: cell
def: "A transitional myocyte that is part of the atrial branch of anterior internodal tract." [GOC:tfm]
xref: FMA:263156
is_a: CL:1000480 ! transitional myocyte of internodal tract

[Term]
id: CL:1000364
name: transitional myocyte of anterior internodal tract
namespace: cell
def: "A transitional myocyte that is part of the anterior internodal tract." [GOC:tfm]
xref: FMA:263158
is_a: CL:1000480 ! transitional myocyte of internodal tract

[Term]
id: CL:1000365
name: transitional myocyte of atrial septal branch of anterior internodal tract
namespace: cell
def: "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm]
xref: FMA:263160
is_a: CL:1000480 ! transitional myocyte of internodal tract

[Term]
id: CL:1000366
name: transitional myocyte of middle internodal tract
namespace: cell
def: "A transitional myocyte that is part of the middle internodal tract." [GOC:tfm]
xref: FMA:263162
is_a: CL:1000480 ! transitional myocyte of internodal tract

[Term]
id: CL:1000367
name: transitional myocyte of posterior internodal tract
namespace: cell
def: "A transitional myocyte that is part of the posterior internodal tract." [GOC:tfm]
xref: FMA:263164
is_a: CL:1000480 ! transitional myocyte of internodal tract

[Term]
id: CL:1000368
name: transitional myocyte of anterior division of left branch of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263166
is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle
relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle

[Term]
id: CL:1000369
name: transitional myocyte of septal division of left branch of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263168
is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle
relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle

[Term]
id: CL:1000370
name: transitional myocyte of left branch of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263170
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0005986 ! left branch of atrioventricular bundle
relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle

[Term]
id: CL:1000371
name: transitional myocyte of right branch of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the right branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263172
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0005987 ! right branch of atrioventricular bundle
relationship: part_of UBERON:0005987 ! right branch of atrioventricular bundle

[Term]
id: CL:1000372
name: transitional myocyte of atrial part of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the atrial part of atrioventricular bundle." [GOC:tfm]
xref: FMA:263174
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle

[Term]
id: CL:1000373
name: transitional myocyte of ventricular part of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." [GOC:tfm]
xref: FMA:263176
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle

[Term]
id: CL:1000374
name: transitional myocyte of posterior division of left branch of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263178
is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle
relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle

[Term]
id: CL:1000375
name: myocardial endocrine cell of septal division of left branch of atrioventricular bundle
namespace: cell
def: "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263180
is_a: CL:0002074 ! myocardial endocrine cell
is_a: CL:2000046 ! ventricular cardiac muscle cell
relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle

[Term]
id: CL:1000376
name: Purkinje myocyte of interventricular septum
namespace: cell
def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263182
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:2000022 ! cardiac septum native cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000377
name: dense-core granulated cell of epithelium of trachea
namespace: cell
def: "A Feyrter cell that is part of the epithelium of trachea." [GOC:tfm]
xref: FMA:263184
is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell
is_a: CL:0002066 {is_inferred="true"} ! Feyrter cell
intersection_of: CL:0002066 ! Feyrter cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea

[Term]
id: CL:1000378
name: type 1 vestibular sensory cell of stato-acoustic epithelium
namespace: cell
def: "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm]
xref: FMA:263186
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0009969 ! statoacoustic epithelium
relationship: part_of UBERON:0009969 ! statoacoustic epithelium

[Term]
id: CL:1000379
name: type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth
namespace: cell
def: "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm]
xref: FMA:263188
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0003241 ! epithelium of utricle

[Term]
id: CL:1000380
name: type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth
namespace: cell
def: "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm]
xref: FMA:263190
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0003242 ! epithelium of saccule

[Term]
id: CL:1000381
name: type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth
namespace: cell
def: "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm]
xref: FMA:263192
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium

[Term]
id: CL:1000382
name: type 2 vestibular sensory cell of stato-acoustic epithelium
namespace: cell
def: "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm]
xref: FMA:263194
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0009969 ! statoacoustic epithelium
relationship: part_of UBERON:0009969 ! statoacoustic epithelium

[Term]
id: CL:1000383
name: type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth
namespace: cell
def: "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm]
xref: FMA:263196
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0003241 ! epithelium of utricle

[Term]
id: CL:1000384
name: type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth
namespace: cell
def: "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm]
xref: FMA:263198
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0003242 ! epithelium of saccule

[Term]
id: CL:1000385
name: type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth
namespace: cell
def: "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm]
xref: FMA:263200
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium

[Term]
id: CL:1000391
name: melanocyte of eyelid
namespace: cell
def: "A melanocyte that is part of the eyelid." [GOC:tfm]
synonym: "eyelid melanocyte" EXACT [FMA:59175]
synonym: "sebaceous gland of wolff" EXACT [FMA:59175]
xref: FMA:59175
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: CL:1000394
name: myoepithelial cell of intralobular lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." [GOC:tfm]
xref: FMA:62158
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000397
name: endothelial cell of venous sinus of red pulp of spleen
namespace: cell
def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [GOC:tfm]
comment: todo - add logical definition to UBERON:0009967
xref: FMA:62817
is_a: CL:0002651 ! endothelial cell of venous sinus of spleen
is_a: CL:2000053 ! splenic endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0009967 ! spleen venous sinus
relationship: part_of UBERON:0009967 ! spleen venous sinus

[Term]
id: CL:1000398
name: endothelial cell of hepatic sinusoid
namespace: cell
def: "An endothelial cell that is part of the hepatic sinusoid." [GOC:tfm]
synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911]
xref: FMA:62911
is_a: CL:0002262 {is_inferred="true"} ! endothelial cell of sinusoid
intersection_of: CL:0002262 ! endothelial cell of sinusoid
intersection_of: part_of UBERON:0001281 ! hepatic sinusoid
relationship: part_of UBERON:0001281 ! hepatic sinusoid

[Term]
id: CL:1000405
name: epithelial cell of appendix
namespace: cell
def: "An epithelial cell that is part of the appendix." [GOC:tfm]
synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602]
synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602]
xref: FMA:63602
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: CL:1000409
name: myocyte of sinoatrial node
namespace: cell
def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm]
synonym: "myocyte of sinoatrial node" EXACT [FMA:67102]
synonym: "SA nodal myocyte" EXACT [FMA:67102]
synonym: "SA node cardiac muscle cell" EXACT [GOC:pr]
synonym: "sinoatrial node cell" EXACT [GOC:pr]
synonym: "sinoatrial node myocyte" EXACT []
synonym: "sinuatrial node myocyte" EXACT [FMA:67102]
xref: FMA:67102
is_a: CL:0002072 ! nodal myocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002351 ! sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node

[Term]
id: CL:1000410
name: myocyte of atrioventricular node
namespace: cell
def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm]
synonym: "atrioventricular node cell" EXACT [GOC:pr]
synonym: "atrioventricular node myocyte" EXACT [FMA:67106]
synonym: "AV nodal myocyte" EXACT [FMA:67106]
synonym: "AV node cardiac muscle cell" EXACT [GOC:pr]
synonym: "AV node cell" EXACT [GOC:pr]
xref: FMA:67106
is_a: CL:0002072 ! nodal myocyte
is_a: CL:2000022 ! cardiac septum native cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002352 ! atrioventricular node
relationship: part_of UBERON:0002352 ! atrioventricular node

[Term]
id: CL:1000411
name: endothelial cell of Peyer's patch
namespace: cell
def: "An endothelial cell that is part of the small intestine Peyer's patch." [GOC:tfm]
xref: FMA:67757
is_a: CL:0000115 {is_inferred="true"} ! endothelial cell
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003454 ! small intestine Peyer's patch
relationship: part_of UBERON:0003454 ! small intestine Peyer's patch

[Term]
id: CL:1000412
name: endothelial cell of arteriole
namespace: cell
def: "An endothelial cell that is part of the arteriole." [GOC:tfm]
xref: FMA:67760
xref: KUPO:0001097
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001980 ! arteriole
relationship: part_of UBERON:0001980 ! arteriole

[Term]
id: CL:1000413
name: endothelial cell of artery
namespace: cell
alt_id: CL:0002542
def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm]
synonym: "arterial endothelial cell" EXACT []
xref: BTO:0004758
xref: FMA:67761
xref: KUPO:0001095
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001917 ! endothelium of artery

[Term]
id: CL:1000414
name: endothelial cell of venule
namespace: cell
def: "An endothelial cell that is part of the venule." [GOC:tfm]
xref: FMA:67762
is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0001979 ! venule
relationship: part_of UBERON:0001979 ! venule

[Term]
id: CL:1000415
name: epithelial cell of gall bladder
namespace: cell
def: "An epithelial cell that is part of the gallbladder." [GOC:tfm]
xref: FMA:67780
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: CL:1000416
name: myoepithelial cell of lactiferous gland
namespace: cell
def: "A myoepithelial cell that is part of the mammary gland." [GOC:tfm]
synonym: "basal cell of lactiferous duct" EXACT [FMA:67800]
xref: CALOHA:TS-2378
xref: FMA:67800
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: CL:1000417
name: myoepithelial cell of sweat gland
namespace: cell
def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm]
xref: FMA:67801
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
is_a: CL:1000448 ! epithelial cell of sweat gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001820 ! sweat gland
relationship: part_of UBERON:0001820 ! sweat gland

[Term]
id: CL:1000418
name: myoepithelial cell of lactiferous alveolus
namespace: cell
def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm]
synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802]
synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802]
xref: FMA:67802
is_a: CL:1000416 ! myoepithelial cell of lactiferous gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0003214 ! mammary gland alveolus
relationship: part_of UBERON:0003214 ! mammary gland alveolus

[Term]
id: CL:1000419
name: myoepithelial cell of lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the lactiferous duct." [GOC:tfm]
xref: FMA:67803
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:1000416 ! myoepithelial cell of lactiferous gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001765 ! mammary duct
relationship: part_of UBERON:0001765 ! mammary duct

[Term]
id: CL:1000420
name: myoepithelial cell of terminal lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the terminal lactiferous duct." [GOC:tfm]
xref: FMA:67804
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000424
name: chromaffin cell of paraaortic body
namespace: cell
def: "A chromaffin cell that is part of the paraaortic body." [GOC:tfm]
synonym: "chromaffin cell of para-aortic body" EXACT [FMA:69328]
xref: FMA:69328
is_a: CL:1000425 ! chromaffin cell of paraganglion
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001237 ! paraaortic body
relationship: part_of UBERON:0001237 ! paraaortic body

[Term]
id: CL:1000425
name: chromaffin cell of paraganglion
namespace: cell
def: "A chromaffin cell that is part of the paraganglion." [GOC:tfm]
xref: FMA:69335
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0012279 ! chromaffin paraganglion
relationship: part_of UBERON:0012279 ! chromaffin paraganglion

[Term]
id: CL:1000426
name: chromaffin cell of adrenal gland
namespace: cell
def: "A chromaffin cell that is part of the adrenal gland." [GOC:tfm]
synonym: "adrenal chromaffin cell" EXACT [GO:0061104]
xref: FMA:69794
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002369 ! adrenal gland
relationship: part_of UBERON:0002369 ! adrenal gland

[Term]
id: CL:1000427
name: adrenal cortex chromaffin cell
namespace: cell
def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm]
comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin.
synonym: "chromaffin cell of adrenal cortex" EXACT []
xref: FMA:69795
is_a: CL:1000426 ! chromaffin cell of adrenal gland
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: part_of UBERON:0001235 ! adrenal cortex

[Term]
id: CL:1000428
name: stem cell of epidermis
namespace: cell
def: "A somatic stem cell that is part of the epidermis." [GOC:tfm]
synonym: "epidermal stem cell" EXACT [FMA:70541]
xref: FMA:70541
is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: CL:1000432
name: conjunctival epithelial cell
namespace: cell
def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm]
synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552]
xref: FMA:70552
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva

[Term]
id: CL:1000433
name: epithelial cell of lacrimal canaliculus
namespace: cell
def: "An epithelial cell that is part of the lacrimal canaliculus." [GOC:tfm]
xref: FMA:70553
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus
relationship: part_of UBERON:0001770 ! lacrimal canaliculus

[Term]
id: CL:1000434
name: epithelial cell of external acoustic meatus
namespace: cell
def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm]
xref: FMA:70555
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001352 ! external acoustic meatus
relationship: part_of UBERON:0001352 ! external acoustic meatus

[Term]
id: CL:1000435
name: epithelial cell of lacrimal duct
namespace: cell
def: "An epithelial cell that is part of the lacrimal duct." [GOC:tfm]
xref: FMA:70559
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0001850 ! lacrimal drainage system
relationship: part_of UBERON:0001850 ! lacrimal drainage system

[Term]
id: CL:1000436
name: epithelial cell of lacrimal sac
namespace: cell
def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm]
xref: FMA:70560
is_a: CL:0000068 ! duct epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001351 ! lacrimal sac
relationship: part_of UBERON:0001351 ! lacrimal sac

[Term]
id: CL:1000437
name: epithelial cell of nasolacrimal duct
namespace: cell
def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm]
xref: FMA:70561
is_a: CL:1000435 ! epithelial cell of lacrimal duct
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0002392 ! nasolacrimal duct
relationship: part_of UBERON:0002392 ! nasolacrimal duct

[Term]
id: CL:1000438
name: epithelial cell of wall of inferior part of anal canal
namespace: cell
def: "An epithelial cell that is part of the wall of inferior part of anal canal." [GOC:tfm]
xref: FMA:70562
is_a: CL:0002634 ! epithelial cell of anal column

[Term]
id: CL:1000441
name: epithelial cell of viscerocranial mucosa
namespace: cell
def: "An epithelial cell that is part of the viscerocranial mucosa." [GOC:tfm]
xref: FMA:70583
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:1000442
name: urothelial cell of trigone of urinary bladder
namespace: cell
def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm]
synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598]
xref: FMA:70598
is_a: CL:0000731 {is_inferred="true"} ! urothelial cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder
relationship: part_of UBERON:0001257 ! trigone of urinary bladder

[Term]
id: CL:1000443
name: ciliary muscle cell
namespace: cell
def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm]
synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610]
xref: FMA:70610
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001775 ! ciliary body
relationship: part_of UBERON:0001775 ! ciliary body

[Term]
id: CL:1000444
name: mesothelial cell of anterior chamber of eye
namespace: cell
def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm]
xref: FMA:70615
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 ! anterior chamber of eyeball

[Term]
id: CL:1000445
name: myoepithelial cell of dilator pupillae
namespace: cell
def: "A myoepithelial cell that is part of the dilatator pupillae." [GOC:tfm]
xref: FMA:70619
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001608 ! dilatator pupillae
relationship: part_of UBERON:0001608 ! dilatator pupillae

[Term]
id: CL:1000447
name: epithelial cell of stratum germinativum of esophagus
namespace: cell
def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm]
synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731]
xref: FMA:70731
is_a: CL:0000646 {is_inferred="true"} ! basal cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0001976 ! epithelium of esophagus
relationship: part_of UBERON:0001976 ! epithelium of esophagus

[Term]
id: CL:1000448
name: epithelial cell of sweat gland
namespace: cell
def: "An epithelial cell that is part of the sweat gland." [GOC:tfm]
xref: FMA:70952
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002308 ! epithelial cell of skin gland
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001820 ! sweat gland
relationship: part_of UBERON:0001820 ! sweat gland

[Term]
id: CL:1000449
name: epithelial cell of nephron
namespace: cell
def: "An epithelial cell that is part of the nephron." [GOC:tfm]
xref: FMA:70965
is_a: CL:0002518 ! kidney epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0001285 ! nephron

[Term]
id: CL:1000450
name: epithelial cell of glomerular capsule
namespace: cell
def: "An epithelial cell that is part of the glomerular capsule." [GOC:tfm]
synonym: "Bowmans capsule epithelial cell" EXACT []
synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966]
xref: FMA:70966
xref: KUPO:0001034
is_a: CL:1000510 ! kidney glomerular epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001230 ! glomerular capsule
relationship: part_of UBERON:0001230 ! glomerular capsule

[Term]
id: CL:1000451
name: epithelial cell of visceral layer of glomerular capsule
namespace: cell
def: "An epithelial cell that is part of the visceral layer of glomerular capsule." [GOC:tfm]
comment: consider merging into CL:0000653
synonym: "glomerular podocyte" NARROW [FMA:70967]
xref: FMA:70967
is_a: CL:1000450 ! epithelial cell of glomerular capsule
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005751 ! visceral layer of glomerular capsule
relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule

[Term]
id: CL:1000452
name: parietal epithelial cell
namespace: cell
alt_id: CL:1000897
def: "An epithelial cell that is part of the glomerular parietal epithelium." [GOC:tfm]
synonym: "epithelial cell of parietal layer of glomerular capsule" EXACT [FMA:70968]
xref: FMA:70968
xref: KUPO:0001035
is_a: CL:1000450 ! epithelial cell of glomerular capsule
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005750 ! glomerular parietal epithelium
relationship: part_of UBERON:0005750 ! glomerular parietal epithelium

[Term]
id: CL:1000453
name: epithelial cell of intermediate tubule
namespace: cell
def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm]
xref: FMA:70980
is_a: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0004136 ! intermediate tubule
relationship: part_of UBERON:0004136 ! intermediate tubule

[Term]
id: CL:1000454
name: kidney collecting duct epithelial cell
namespace: cell
def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm]
synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982]
xref: FMA:70982
xref: KUPO:0001059
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: CL:1000456
name: mesothelial cell of parietal peritoneum
namespace: cell
def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm]
xref: FMA:72142
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001366 ! parietal peritoneum
relationship: part_of UBERON:0001366 ! parietal peritoneum

[Term]
id: CL:1000457
name: mesothelial cell of visceral peritoneum
namespace: cell
def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm]
xref: FMA:72143
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001178 ! visceral peritoneum
relationship: part_of UBERON:0001178 ! visceral peritoneum

[Term]
id: CL:1000458
name: melanocyte of skin
namespace: cell
def: "A melanocyte that is part of the skin of body." [GOC:tfm]
synonym: "skin melanocyte" EXACT [FMA:72144]
xref: CALOHA:TS-2374
xref: FMA:72144
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: CL:1000465
name: chromaffin cell of ovary
namespace: cell
def: "A chromaffin cell that is part of the ovary." [GOC:tfm]
xref: FMA:74319
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
is_a: CL:2000064 ! ovarian surface epithelial cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: CL:1000466
name: chromaffin cell of right ovary
namespace: cell
def: "A chromaffin cell that is part of the right ovary." [GOC:tfm]
xref: FMA:74320
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002118 ! right ovary
relationship: part_of UBERON:0002118 ! right ovary

[Term]
id: CL:1000467
name: chromaffin cell of left ovary
namespace: cell
def: "A chromaffin cell that is part of the left ovary." [GOC:tfm]
xref: FMA:74321
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002119 ! left ovary
relationship: part_of UBERON:0002119 ! left ovary

[Term]
id: CL:1000468
name: myoepithelial cell of acinus of lactiferous gland
namespace: cell
def: "A myoepithelial cell that is part of the acinus of lactiferous gland." [GOC:tfm]
synonym: "basal cell of acinus of lactiferous gland" EXACT [FMA:74469]
xref: FMA:74469
is_a: CL:1000416 ! myoepithelial cell of lactiferous gland
relationship: part_of UBERON:0001912 ! lobule of mammary gland

[Term]
id: CL:1000469
name: myoepithelial cell of main lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the main lactiferous duct." [GOC:tfm]
xref: FMA:74499
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000470
name: myoepithelial cell of primary lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the primary lactiferous duct." [GOC:tfm]
xref: FMA:74500
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000471
name: myoepithelial cell of secondary lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the secondary lactiferous duct." [GOC:tfm]
xref: FMA:74501
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000472
name: myoepithelial cell of tertiary lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the tertiary lactiferous duct." [GOC:tfm]
xref: FMA:74502
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000473
name: myoepithelial cell of quarternary lactiferous duct
namespace: cell
def: "A myoepithelial cell that is part of the quarternary lactiferous duct." [GOC:tfm]
xref: FMA:74503
is_a: CL:0000185 ! myoepithelial cell

[Term]
id: CL:1000477
name: cardiac pacemaker cell of sinoatrial node
namespace: cell
def: "A nodal myocyte that is part of the sinoatrial node." [GOC:tfm]
synonym: "cardiac pacemaker cell of sinuatrial node" EXACT []
synonym: "pacemaker cell of sinoatrial node" EXACT []
synonym: "pacemaker cell of sinuatrial node" EXACT []
xref: FMA:83383
is_a: CL:1000409 ! myocyte of sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node

[Term]
id: CL:1000478
name: transitional myocyte of sinoatrial node
namespace: cell
def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm]
synonym: "transitinal myocyte of sinuatrial node" EXACT []
xref: FMA:83384
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:1000409 ! myocyte of sinoatrial node
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002351 ! sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node

[Term]
id: CL:1000479
name: Purkinje myocyte of atrioventricular node
namespace: cell
def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm]
xref: FMA:83386
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:1000410 ! myocyte of atrioventricular node
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002352 ! atrioventricular node
relationship: part_of UBERON:0002352 ! atrioventricular node

[Term]
id: CL:1000480
name: transitional myocyte of internodal tract
namespace: cell
def: "A transitional myocyte that is part of the internodal tract." [GOC:tfm]
xref: FMA:83387
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:0002096 ! internodal tract myocyte
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract

[Term]
id: CL:1000481
name: transitional myocyte of atrioventricular bundle
namespace: cell
def: "A transitional myocyte that is part of the atrioventricular bundle." [GOC:tfm]
xref: FMA:83388
xref: FMA:83885
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:0010005 ! atrioventricular bundle cell
is_a: CL:2000046 ! ventricular cardiac muscle cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002353 ! atrioventricular bundle
relationship: part_of UBERON:0002353 ! atrioventricular bundle

[Term]
id: CL:1000482
name: myocardial endocrine cell of interventricular septum
namespace: cell
def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm]
xref: FMA:83390
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
is_a: CL:2000022 ! cardiac septum native cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000483
name: Purkinje myocyte of internodal tract
namespace: cell
def: "A Purkinje myocyte that is part of the internodal tract." [GOC:tfm]
xref: FMA:83392
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:0002096 ! internodal tract myocyte
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract

[Term]
id: CL:1000484
name: Purkinje myocyte of atrioventricular bundle
namespace: cell
def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm]
xref: FMA:83393
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:0010005 ! atrioventricular bundle cell
is_a: CL:2000046 ! ventricular cardiac muscle cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002353 ! atrioventricular bundle
relationship: part_of UBERON:0002353 ! atrioventricular bundle

[Term]
id: CL:1000486
name: basal cell of urothelium
namespace: cell
def: "A basal cell that is part of the urothelium." [GOC:tfm]
xref: FMA:84150
is_a: CL:0000646 {is_inferred="true"} ! basal cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0000365 ! urothelium
relationship: part_of UBERON:0000365 ! urothelium

[Term]
id: CL:1000487
name: smooth muscle cell of prostate
namespace: cell
def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm]
synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583]
xref: FMA:84583
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: CL:1000488
name: cholangiocyte
namespace: cell
def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246]
synonym: "epithelial cell of bile duct" EXACT []
xref: FMA:86481
is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0002394 ! bile duct
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002394 ! bile duct

[Term]
id: CL:1000489
name: reticular cell of splenic cord
namespace: cell
def: "A reticular cell that is part of the splenic cord." [GOC:tfm]
xref: FMA:86497
is_a: CL:0000432 {is_inferred="true"} ! reticular cell
is_a: CL:2000051 ! splenic fibroblast
intersection_of: CL:0000432 ! reticular cell
intersection_of: part_of UBERON:0001266 ! splenic cord
relationship: part_of UBERON:0001266 ! splenic cord

[Term]
id: CL:1000490
name: mesothelial cell of peritoneum
namespace: cell
def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm]
synonym: "peritoneal mesothelial cell" EXACT [FMA:86736]
xref: FMA:86736
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum

[Term]
id: CL:1000491
name: mesothelial cell of pleura
namespace: cell
def: "A mesothelial cell that is part of the pleura." [GOC:tfm]
synonym: "pleural mesothelial cell" EXACT [FMA:86737]
xref: FMA:86737
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0000977 ! pleura
relationship: part_of UBERON:0000977 ! pleura

[Term]
id: CL:1000492
name: mesothelial cell of parietal pleura
namespace: cell
def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm]
xref: FMA:86738
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002400 ! parietal pleura
relationship: part_of UBERON:0002400 ! parietal pleura

[Term]
id: CL:1000493
name: mesothelial cell of visceral pleura
namespace: cell
def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm]
xref: FMA:86739
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002401 ! visceral pleura
relationship: part_of UBERON:0002401 ! visceral pleura

[Term]
id: CL:1000494
name: nephron tubule epithelial cell
namespace: cell
def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm]
comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON.
synonym: "kidney tubule epithelial cell" EXACT []
xref: FMA:86785
xref: KUPO:0001022
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004810 ! nephron tubule epithelium
relationship: part_of UBERON:0004810 ! nephron tubule epithelium

[Term]
id: CL:1000495
name: small intestine goblet cell
namespace: cell
def: "A goblet cell that is part of the small intestine." [GOC:tfm]
synonym: "goblet cell of epithelium of small intestine" EXACT []
synonym: "goblet cell of small intestine" EXACT []
synonym: "small intestinal goblet cell" EXACT [FMA:86929]
xref: FMA:86929
is_a: CL:0000160 ! goblet cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: CL:1000497
name: kidney cell
namespace: cell
xref: KUPO:0001010
is_a: CL:0000548 {is_inferred="true"} ! animal cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: CL:1000500
name: kidney interstitial cell
namespace: cell
xref: KUPO:0001013
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005215 ! kidney interstitium
relationship: part_of UBERON:0005215 ! kidney interstitium

[Term]
id: CL:1000504
name: kidney medulla cell
namespace: cell
xref: KUPO:0001017
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla

[Term]
id: CL:1000505
name: kidney pelvis cell
namespace: cell
xref: KUPO:0001018
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
is_a: CL:1000601 ! ureteral cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis

[Term]
id: CL:1000507
name: kidney tubule cell
namespace: cell
xref: KUPO:0001020
is_a: CL:1000449 ! epithelial cell of nephron
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule

[Term]
id: CL:1000510
name: kidney glomerular epithelial cell
namespace: cell
xref: KUPO:0001023
is_a: CL:1000746 ! glomerular cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0004188 ! glomerular epithelium
relationship: part_of UBERON:0004188 ! glomerular epithelium

[Term]
id: CL:1000546
name: kidney medulla collecting duct epithelial cell
namespace: cell
xref: KUPO:0001060
is_a: CL:1000504 ! kidney medulla cell
is_a: CL:1001225 ! kidney collecting duct cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct
relationship: part_of UBERON:0005185 ! renal medulla collecting duct

[Term]
id: CL:1000547
name: kidney inner medulla collecting duct epithelial cell
namespace: cell
xref: KUPO:0001061
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005187
relationship: part_of UBERON:0005187

[Term]
id: CL:1000548
name: kidney outer medulla collecting duct epithelial cell
namespace: cell
xref: KUPO:0001062
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005186
relationship: part_of UBERON:0005186

[Term]
id: CL:1000549
name: kidney cortex collecting duct epithelial cell
namespace: cell
xref: KUPO:0001063
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005267
relationship: part_of UBERON:0005267

[Term]
id: CL:1000550
name: kidney papillary duct principal epithelial cell
namespace: cell
xref: KUPO:0001064
is_a: CL:1001225 ! kidney collecting duct cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005167 ! papillary duct
relationship: part_of UBERON:0005167 ! papillary duct

[Term]
id: CL:1000596
name: inner renal cortex cell
namespace: cell
xref: KUPO:0001111
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005271 ! juxtamedullary cortex
relationship: part_of UBERON:0005271 ! juxtamedullary cortex

[Term]
id: CL:1000597
name: papillary tips cell
namespace: cell
xref: KUPO:0001112
is_a: CL:1000505 ! kidney pelvis cell
is_a: CL:1000617 ! kidney inner medulla cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0009095 ! tip of renal papilla
relationship: part_of UBERON:0009095 ! tip of renal papilla

[Term]
id: CL:1000600
name: lower urinary tract cell
namespace: cell
xref: KUPO:0001115
is_a: CL:0000548 {is_inferred="true"} ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0001556 ! lower urinary tract
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: CL:1000601
name: ureteral cell
namespace: cell
xref: KUPO:0001116
is_a: CL:0000548 {is_inferred="true"} ! animal cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter

[Term]
id: CL:1000606
name: kidney nerve cell
namespace: cell
xref: KUPO:0001015
is_a: CL:0000540 ! neuron
is_a: CL:1000500 ! kidney interstitial cell
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: CL:1000612
name: kidney corpuscule cell
namespace: cell
xref: KUPO:0001021
is_a: CL:0002584 {is_inferred="true"} ! renal cortical epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
intersection_of: CL:0002584 ! renal cortical epithelial cell
intersection_of: part_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0001229 ! renal corpuscle

[Term]
id: CL:1000615
name: kidney cortex tubule cell
namespace: cell
xref: KUPO:0001024
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000494 ! nephron tubule epithelial cell
intersection_of: CL:1000507 ! kidney tubule cell
intersection_of: part_of UBERON:0006853 ! renal cortex tubule
relationship: part_of UBERON:0006853 ! renal cortex tubule

[Term]
id: CL:1000616
name: kidney outer medulla cell
namespace: cell
xref: KUPO:0001025
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: CL:1000617
name: kidney inner medulla cell
namespace: cell
xref: KUPO:0001026
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney

[Term]
id: CL:1000618
name: juxtaglomerular complex cell
namespace: cell
synonym: "juxtaglomerulus cell" EXACT [GO:0072052]
xref: KUPO:0001028
is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell
intersection_of: CL:0002681 ! kidney cortical cell
intersection_of: part_of UBERON:0002303 ! juxtaglomerular apparatus
relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus

[Term]
id: CL:1000681
name: kidney cortex interstitial cell
namespace: cell
xref: KUPO:0001091
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell
intersection_of: CL:1000500 ! kidney interstitial cell
intersection_of: part_of UBERON:0005270 ! renal cortex interstitium
relationship: part_of UBERON:0005270 ! renal cortex interstitium

[Term]
id: CL:1000682
name: kidney medulla interstitial cell
namespace: cell
xref: KUPO:0001092
is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000500 ! kidney interstitial cell
intersection_of: part_of UBERON:0005211 ! renal medulla interstitium
relationship: part_of UBERON:0005211 ! renal medulla interstitium

[Term]
id: CL:1000691
name: kidney interstitial myofibroblast
namespace: cell
xref: KUPO:0001101
is_a: CL:0000186 ! myofibroblast cell
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000692
name: kidney interstitial fibroblast
namespace: cell
xref: KUPO:0001102
is_a: CL:0000057 ! fibroblast
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000693
name: kidney interstitial fibrocyte
namespace: cell
xref: KUPO:0001103
is_a: CL:0000135 ! fibrocyte
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000695
name: kidney interstitial alternatively activated macrophage
namespace: cell
xref: KUPO:0001106
is_a: CL:0000890 ! alternatively activated macrophage
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000696
name: kidney interstitial inflammatory macrophage
namespace: cell
xref: KUPO:0001107
is_a: CL:0000863 ! inflammatory macrophage
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000697
name: kidney interstitial suppressor macrophage
namespace: cell
xref: KUPO:0001108
is_a: CL:0000862 ! suppressor macrophage
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000698
name: kidney resident macrophage
namespace: cell
xref: KUPO:0001109
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000699
name: kidney resident dendritic cell
namespace: cell
xref: KUPO:0001110
is_a: CL:0001007 ! interstitial dendritic cell
is_a: CL:1000500 ! kidney interstitial cell

[Term]
id: CL:1000702
name: kidney pelvis smooth muscle cell
namespace: cell
xref: KUPO:0001113
is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell
is_a: CL:1000979 ! ureter smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle
relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle

[Term]
id: CL:1000703
name: kidney pelvis urothelial cell
namespace: cell
xref: KUPO:0001114
is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell
is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell
is_a: CL:1000706 ! ureter urothelial cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0004788 ! kidney pelvis urothelium
relationship: part_of UBERON:0004788 ! kidney pelvis urothelium

[Term]
id: CL:1000706
name: ureter urothelial cell
namespace: cell
xref: KUPO:0001117
is_a: CL:0000731 {is_inferred="true"} ! urothelial cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0001254 ! urothelium of ureter
relationship: part_of UBERON:0001254 ! urothelium of ureter

[Term]
id: CL:1000708
name: ureter adventitial cell
namespace: cell
xref: KUPO:0001119
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002503 ! adventitial cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:1000601 ! ureteral cell
intersection_of: part_of UBERON:0001252 ! adventitia of ureter
relationship: part_of UBERON:0001252 ! adventitia of ureter

[Term]
id: CL:1000714
name: kidney cortex collecting duct principal cell
namespace: cell
xref: KUPO:0001130
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005267
relationship: part_of UBERON:0005267

[Term]
id: CL:1000715
name: kidney cortex collecting duct intercalated cell
namespace: cell
xref: KUPO:0001131
is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
intersection_of: CL:0005010 ! renal intercalated cell
intersection_of: part_of UBERON:0005267
relationship: part_of UBERON:0005267

[Term]
id: CL:1000716
name: kidney outer medulla collecting duct principal cell
namespace: cell
xref: KUPO:0001132
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005186
relationship: part_of UBERON:0005186

[Term]
id: CL:1000717
name: kidney outer medulla collecting duct intercalated cell
namespace: cell
xref: KUPO:0001133
is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell
is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell
intersection_of: CL:0005010 ! renal intercalated cell
intersection_of: part_of UBERON:0005186
relationship: part_of UBERON:0005186

[Term]
id: CL:1000718
name: kidney inner medulla collecting duct principal cell
namespace: cell
xref: KUPO:0001134
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005187
relationship: part_of UBERON:0005187

[Term]
id: CL:1000719
name: kidney inner medulla collecting duct intercalated cell
namespace: cell
xref: KUPO:0001135
is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell
is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell
intersection_of: CL:0005010 ! renal intercalated cell
intersection_of: part_of UBERON:0005187
relationship: part_of UBERON:0005187

[Term]
id: CL:1000720
name: kidney papillary duct intercalated cell
namespace: cell
xref: KUPO:0001136
is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell
is_a: CL:1001432 ! kidney collecting duct intercalated cell
intersection_of: CL:0005010 ! renal intercalated cell
intersection_of: part_of UBERON:0005167 ! papillary duct
relationship: part_of UBERON:0005167 ! papillary duct

[Term]
id: CL:1000721
name: kidney papillary duct principal cell
namespace: cell
xref: KUPO:0001137
is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005167 ! papillary duct
relationship: part_of UBERON:0005167 ! papillary duct

[Term]
id: CL:1000742
name: glomerular mesangial cell
namespace: cell
def: "Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney." [Wikipedia:Intraglomerular_mesangial_cell]
synonym: "intraglomerular mesangial cell" EXACT [CL:cjm]
xref: KUPO:0001032
is_a: CL:0000650 ! mesangial cell
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:1000746 ! glomerular cell
is_a: CL:1001318 ! renal interstitial pericyte
intersection_of: CL:1000612 ! kidney corpuscule cell
intersection_of: part_of UBERON:0002320 ! glomerular mesangium
relationship: part_of UBERON:0002320 ! glomerular mesangium

[Term]
id: CL:1000746
name: glomerular cell
namespace: cell
xref: KUPO:0001036
is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell
intersection_of: CL:1000612 ! kidney corpuscule cell
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus

[Term]
id: CL:1000768
name: kidney connecting tubule epithelial cell
namespace: cell
xref: KUPO:0001058
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0005097 ! renal connecting tubule
relationship: part_of UBERON:0005097 ! renal connecting tubule

[Term]
id: CL:1000803
name: kidney inner medulla interstitial cell
namespace: cell
xref: KUPO:0001093
is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell
is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell
intersection_of: CL:1000682 ! kidney medulla interstitial cell
intersection_of: part_of UBERON:0005214 ! inner renal medulla interstitium
relationship: part_of UBERON:0005214 ! inner renal medulla interstitium

[Term]
id: CL:1000804
name: kidney outer medulla interstitial cell
namespace: cell
xref: KUPO:0001094
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell
intersection_of: CL:1000682 ! kidney medulla interstitial cell
intersection_of: part_of UBERON:0005213 ! outer renal medulla interstitium
relationship: part_of UBERON:0005213 ! outer renal medulla interstitium

[Term]
id: CL:1000838
name: kidney proximal convoluted tubule epithelial cell
namespace: cell
xref: KUPO:0001045
is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: part_of UBERON:0001287 ! proximal convoluted tubule
relationship: part_of UBERON:0001287 ! proximal convoluted tubule

[Term]
id: CL:1000839
name: kidney proximal straight tubule epithelial cell
namespace: cell
xref: KUPO:0001046
is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: part_of UBERON:0001290 ! proximal straight tubule
relationship: part_of UBERON:0001290 ! proximal straight tubule

[Term]
id: CL:1000849
name: kidney distal convoluted tubule epithelial cell
namespace: cell
xref: KUPO:0001056
is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule
intersection_of: CL:0002305 ! epithelial cell of distal tubule
intersection_of: part_of UBERON:0001292 ! distal convoluted tubule
relationship: part_of UBERON:0001292 ! distal convoluted tubule

[Term]
id: CL:1000850
name: macula densa epithelial cell
namespace: cell
xref: KUPO:0001057
is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule
is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell
intersection_of: CL:0002305 ! epithelial cell of distal tubule
intersection_of: part_of UBERON:0002335 ! macula densa
relationship: part_of UBERON:0002335 ! macula densa

[Term]
id: CL:1000854
name: kidney blood vessel cell
namespace: cell
xref: KUPO:0001014
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: part_of UBERON:0003517 ! kidney blood vessel
relationship: part_of UBERON:0003517 ! kidney blood vessel
relationship: participates_in GO:0008015 ! blood circulation

[Term]
id: CL:1000891
name: kidney arterial blood vessel cell
namespace: cell
xref: KUPO:0001029
is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell
intersection_of: CL:1000854 ! kidney blood vessel cell
intersection_of: part_of UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0003644 ! kidney arterial blood vessel

[Term]
id: CL:1000892
name: kidney capillary endothelial cell
namespace: cell
xref: KUPO:0001030
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:1000854 ! kidney blood vessel cell
intersection_of: CL:1000854 ! kidney blood vessel cell
intersection_of: part_of UBERON:0003527 ! kidney capillary
relationship: part_of UBERON:0003527 ! kidney capillary

[Term]
id: CL:1000893
name: kidney venous blood vessel cell
namespace: cell
xref: KUPO:0001031
is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell
intersection_of: CL:1000854 ! kidney blood vessel cell
intersection_of: part_of UBERON:0001140 ! renal vein
relationship: part_of UBERON:0001140 ! renal vein

[Term]
id: CL:1000909
name: kidney loop of Henle epithelial cell
namespace: cell
xref: KUPO:0001047
is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0001288 ! loop of Henle
relationship: part_of UBERON:0001288 ! loop of Henle

[Term]
id: CL:1000979
name: ureter smooth muscle cell
namespace: cell
xref: KUPO:0001118
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0006855 ! muscular coat of ureter
relationship: part_of UBERON:0006855 ! muscular coat of ureter

[Term]
id: CL:1001005
name: glomerular capillary endothelial cell
namespace: cell
xref: KUPO:0001037
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:0002188 ! glomerular endothelial cell
is_a: CL:1000510 ! kidney glomerular epithelial cell
is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell
intersection_of: CL:1000892 ! kidney capillary endothelial cell
intersection_of: part_of UBERON:0004294 ! glomerular capillary endothelium
relationship: part_of UBERON:0004294 ! glomerular capillary endothelium

[Term]
id: CL:1001006
name: kidney afferent arteriole cell
namespace: cell
xref: KUPO:0001038
is_a: CL:1000612 ! kidney corpuscule cell
is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole

[Term]
id: CL:1001009
name: kidney efferent arteriole cell
namespace: cell
xref: KUPO:0001041
is_a: CL:1000612 ! kidney corpuscule cell
is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole

[Term]
id: CL:1001016
name: kidney loop of Henle ascending limb epithelial cell
namespace: cell
xref: KUPO:0001048
is_a: CL:0002305 ! epithelial cell of distal tubule
is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell
intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: part_of UBERON:0005164 ! ascending limb of loop of Henle
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle

[Term]
id: CL:1001021
name: kidney loop of Henle descending limb epithelial cell
namespace: cell
xref: KUPO:0001053
is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell
intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: part_of UBERON:0001289 ! descending limb of loop of Henle
relationship: part_of UBERON:0001289 ! descending limb of loop of Henle

[Term]
id: CL:1001033
name: peritubular capillary endothelial cell
namespace: cell
xref: KUPO:0001065
is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell
intersection_of: CL:1000892 ! kidney capillary endothelial cell
intersection_of: part_of UBERON:0005272 ! peritubular capillary
relationship: part_of UBERON:0005272 ! peritubular capillary

[Term]
id: CL:1001036
name: vasa recta cell
namespace: cell
xref: KUPO:0001068
is_a: CL:0002543 ! vein endothelial cell
is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell
is_a: CL:1000893 ! kidney venous blood vessel cell
intersection_of: CL:1000892 ! kidney capillary endothelial cell
intersection_of: part_of UBERON:0004726 ! vasa recta
relationship: part_of UBERON:0004726 ! vasa recta

[Term]
id: CL:1001045
name: kidney cortex artery cell
namespace: cell
xref: KUPO:0001077
is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0005268 ! renal cortex artery
relationship: part_of UBERON:0005268 ! renal cortex artery

[Term]
id: CL:1001052
name: kidney cortex vein cell
namespace: cell
xref: KUPO:0001084
is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell
intersection_of: CL:1000893 ! kidney venous blood vessel cell
intersection_of: part_of UBERON:0005269 ! renal cortex vein
relationship: part_of UBERON:0005269 ! renal cortex vein

[Term]
id: CL:1001064
name: kidney artery smooth muscle cell
namespace: cell
comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001096
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000891 ! kidney arterial blood vessel cell

[Term]
id: CL:1001066
name: kidney arteriole smooth muscle cell
namespace: cell
comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001098
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000891 ! kidney arterial blood vessel cell

[Term]
id: CL:1001068
name: kidney venous system smooth muscle cell
namespace: cell
comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001100
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000893 ! kidney venous blood vessel cell

[Term]
id: CL:1001096
name: kidney afferent arteriole endothelial cell
namespace: cell
xref: KUPO:0001039
is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole
is_a: CL:1001006 ! kidney afferent arteriole cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole

[Term]
id: CL:1001097
name: kidney afferent arteriole smooth muscle cell
namespace: cell
xref: KUPO:0001040
is_a: CL:1001006 ! kidney afferent arteriole cell
is_a: CL:1001066 ! kidney arteriole smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole

[Term]
id: CL:1001099
name: kidney efferent arteriole endothelial cell
namespace: cell
xref: KUPO:0001042
is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole
is_a: CL:1001009 ! kidney efferent arteriole cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole

[Term]
id: CL:1001100
name: kidney efferent arteriole smooth muscle cell
namespace: cell
xref: KUPO:0001043
is_a: CL:1001009 ! kidney efferent arteriole cell
is_a: CL:1001066 ! kidney arteriole smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole

[Term]
id: CL:1001106
name: kidney loop of Henle thick ascending limb epithelial cell
namespace: cell
xref: KUPO:0001049
is_a: CL:1000504 ! kidney medulla cell
is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle

[Term]
id: CL:1001107
name: kidney loop of Henle thin ascending limb epithelial cell
namespace: cell
xref: KUPO:0001050
is_a: CL:1000617 ! kidney inner medulla cell
is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment
relationship: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment

[Term]
id: CL:1001108
name: kidney loop of Henle medullary thick ascending limb epithelial cell
namespace: cell
xref: KUPO:0001051
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0006376 ! premacula segment of distal straight tubule
relationship: part_of UBERON:0006376 ! premacula segment of distal straight tubule

[Term]
id: CL:1001109
name: kidney loop of Henle cortical thick ascending limb epithelial cell
namespace: cell
xref: KUPO:0001052
is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0006854 ! distal straight tubule postmacula segment
relationship: part_of UBERON:0006854 ! distal straight tubule postmacula segment

[Term]
id: CL:1001111
name: kidney loop of Henle thin descending limb epithelial cell
namespace: cell
xref: KUPO:0001054
is_a: CL:1000453 ! epithelial cell of intermediate tubule
is_a: CL:1000616 ! kidney outer medulla cell
is_a: CL:1001021 {is_inferred="true"} ! kidney loop of Henle descending limb epithelial cell
intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: part_of UBERON:0005096 ! descending thin limb
relationship: part_of UBERON:0005096 ! descending thin limb

[Term]
id: CL:1001123
name: kidney outer medulla peritubular capillary cell
namespace: cell
xref: KUPO:0001066
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell
intersection_of: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: part_of UBERON:0006341 ! outer renal medulla peritubular capillary
relationship: part_of UBERON:0006341 ! outer renal medulla peritubular capillary

[Term]
id: CL:1001124
name: kidney cortex peritubular capillary cell
namespace: cell
xref: KUPO:0001067
is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell
intersection_of: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: part_of UBERON:0006851 ! renal cortex peritubular capillary
relationship: part_of UBERON:0006851 ! renal cortex peritubular capillary

[Term]
id: CL:1001126
name: inner renal medulla vasa recta cell
namespace: cell
xref: KUPO:0001069
is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0004776 ! inner renal medulla vasa recta
relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta

[Term]
id: CL:1001127
name: outer renal medulla vasa recta cell
namespace: cell
xref: KUPO:0001070
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0004775 ! outer renal medulla vasa recta
relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta

[Term]
id: CL:1001131
name: vasa recta ascending limb cell
namespace: cell
xref: KUPO:0001074
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0009091 ! vasa recta ascending limb
relationship: part_of UBERON:0009091 ! vasa recta ascending limb

[Term]
id: CL:1001135
name: arcuate artery cell
namespace: cell
xref: KUPO:0001078
is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell
intersection_of: CL:1001045 ! kidney cortex artery cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery

[Term]
id: CL:1001138
name: interlobular artery cell
namespace: cell
xref: KUPO:0001081
is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell
intersection_of: CL:1001045 ! kidney cortex artery cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery

[Term]
id: CL:1001142
name: arcuate vein cell
namespace: cell
xref: KUPO:0001085
is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell
intersection_of: CL:1001052 ! kidney cortex vein cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein

[Term]
id: CL:1001145
name: interlobular vein cell
namespace: cell
xref: KUPO:0001088
is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell
intersection_of: CL:1001052 ! kidney cortex vein cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein

[Term]
id: CL:1001209
name: inner medulla vasa recta ascending limb cell
namespace: cell
xref: KUPO:0001075
is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell
is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell
intersection_of: CL:1001131 ! vasa recta ascending limb cell
intersection_of: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb
relationship: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb

[Term]
id: CL:1001210
name: outer medulla vasa recta ascending limb cell
namespace: cell
xref: KUPO:0001076
is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell
is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell
intersection_of: CL:1001131 ! vasa recta ascending limb cell
intersection_of: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb
relationship: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb

[Term]
id: CL:1001213
name: arcuate artery endothelial cell
namespace: cell
xref: KUPO:0001079
is_a: CL:1000413 {is_inferred="true"} ! endothelial cell of artery
is_a: CL:1001135 ! arcuate artery cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery

[Term]
id: CL:1001214
name: arcuate artery smooth muscle cell
namespace: cell
xref: KUPO:0001080
is_a: CL:1001064 ! kidney artery smooth muscle cell
is_a: CL:1001135 ! arcuate artery cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery

[Term]
id: CL:1001216
name: interlobulary artery endothelial cell
namespace: cell
xref: KUPO:0001082
is_a: CL:1000413 ! endothelial cell of artery
is_a: CL:1001138 ! interlobular artery cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery

[Term]
id: CL:1001217
name: interlobulary artery smooth muscle cell
namespace: cell
xref: KUPO:0001083
is_a: CL:1001064 ! kidney artery smooth muscle cell
is_a: CL:1001138 ! interlobular artery cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery

[Term]
id: CL:1001220
name: arcuate vein endothelial cell
namespace: cell
xref: KUPO:0001086
is_a: CL:0002543 ! vein endothelial cell
is_a: CL:1001142 ! arcuate vein cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein

[Term]
id: CL:1001221
name: arcuate vein smooth muscle cell
namespace: cell
xref: KUPO:0001087
is_a: CL:1001068 ! kidney venous system smooth muscle cell
is_a: CL:1001142 ! arcuate vein cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein

[Term]
id: CL:1001223
name: interlobulary vein endothelial cell
namespace: cell
xref: KUPO:0001089
is_a: CL:0002543 ! vein endothelial cell
is_a: CL:1001145 ! interlobular vein cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein

[Term]
id: CL:1001224
name: interlobulary vein smooth muscle cell
namespace: cell
xref: KUPO:0001090
is_a: CL:1001068 ! kidney venous system smooth muscle cell
is_a: CL:1001145 ! interlobular vein cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein

[Term]
id: CL:1001225
name: kidney collecting duct cell
namespace: cell
xref: KUPO:0001012
xref: Wikipedia:Kidney_collecting_duct_cell
is_a: CL:1000449 ! epithelial cell of nephron
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: CL:1001285
name: vasa recta descending limb cell
namespace: cell
xref: KUPO:0001071
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0009202 ! vasa recta descending limb
relationship: part_of UBERON:0009202 ! vasa recta descending limb

[Term]
id: CL:1001286
name: inner medulla vasa recta descending limb cell
namespace: cell
xref: KUPO:0001072
is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell
is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell
intersection_of: CL:1001285 ! vasa recta descending limb cell
intersection_of: part_of UBERON:0009089 ! inner medulla vasa recta descending limb
relationship: part_of UBERON:0009089 ! inner medulla vasa recta descending limb

[Term]
id: CL:1001287
name: outer medulla vasa recta descending limb cell
namespace: cell
xref: KUPO:0001073
is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell
is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell
intersection_of: CL:1001285 ! vasa recta descending limb cell
intersection_of: part_of UBERON:0009090 ! outer medulla vasa recta descending limb
relationship: part_of UBERON:0009090 ! outer medulla vasa recta descending limb

[Term]
id: CL:1001318
name: renal interstitial pericyte
namespace: cell
xref: KUPO:0001104
is_a: CL:0000669 {is_inferred="true"} ! pericyte cell
is_a: CL:1000497 ! kidney cell
intersection_of: CL:0000669 ! pericyte cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: CL:1001319
name: bladder cell
namespace: cell
xref: KUPO:0001120
is_a: CL:1000600 ! lower urinary tract cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: CL:1001320
name: urethra cell
namespace: cell
xref: KUPO:0001123
is_a: CL:1000600 ! lower urinary tract cell
intersection_of: CL:0000548 ! animal cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: CL:1001428
name: bladder urothelial cell
namespace: cell
xref: KUPO:0001121
is_a: CL:0000731 {is_inferred="true"} ! urothelial cell
is_a: CL:1001319 {is_inferred="true"} ! bladder cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0004645 ! urinary bladder urothelium
relationship: part_of UBERON:0004645 ! urinary bladder urothelium

[Term]
id: CL:1001430
name: urethra urothelial cell
namespace: cell
xref: KUPO:0001124
is_a: CL:0000731 {is_inferred="true"} ! urothelial cell
is_a: CL:1000296 ! epithelial cell of urethra
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0004787 ! urethra urothelium
relationship: part_of UBERON:0004787 ! urethra urothelium

[Term]
id: CL:1001431
name: kidney collecting duct principal cell
namespace: cell
xref: KUPO:0001128
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: CL:1001432
name: kidney collecting duct intercalated cell
namespace: cell
xref: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells
xref: KUPO:0001129
is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0005010 ! renal intercalated cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: CL:1001433
name: epithelial cell of exocrine pancreas
namespace: cell
def: "An epithelial cell of the exocrine pancreas." [GOC:tfm]
synonym: "exocrine pancreas cell" EXACT []
xref: FMA:70986
is_a: CL:0000083 ! epithelial cell of pancreas
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas

[Term]
id: CL:1001434
name: olfactory bulb interneuron
namespace: cl
def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0002264 ! olfactory bulb
relationship: part_of UBERON:0002264 ! olfactory bulb

[Term]
id: CL:1001435
name: periglomerular cell
namespace: cl
def: "the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [MP:0009943]
synonym: "glomerular layer cell" EXACT [NIFSTD:nifext_122]
synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIFSTD:nifext_122]
synonym: "olfactory bulb glomerular layer cell" EXACT [NIFSTD:nifext_122]
synonym: "olfactory bulb glomerularal cell" EXACT [MP:0009943]
synonym: "periglomerular cell" EXACT [NIFSTD:nifext_122]
xref: BTO:0003796
xref: NIFSTD:nifext_122
is_a: CL:1001434 ! olfactory bulb interneuron
relationship: part_of UBERON:0005377 ! olfactory bulb glomerular layer

[Term]
id: CL:1001436
name: hair-tylotrich neuron
namespace: cl
def: "the subcutaneous mechanoreceptors that innervate tylotrich hair follicles" [MP:0000977]
is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell

[Term]
id: CL:1001437
name: hair-down neuron
namespace: cl
def: "the subcutaneous mechanoreceptors that innervate vellus hairs" [MP:0000979]
is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell

[Term]
id: CL:1001451
name: sensory neuron of dorsal root ganglion
namespace: cl
def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297]
synonym: "proprioceptive neuron" EXACT [MP:0004297]
is_a: CL:0000101 {is_inferred="true"} ! sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: part_of UBERON:0000044 ! dorsal root ganglion
relationship: part_of UBERON:0000044 ! dorsal root ganglion

[Term]
id: CL:1001474
name: medium spiny neuron
namespace: cl
def: "the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [MP:0008462]
synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778]
synonym: "striatal medium spiny neuron" EXACT [GO:0021773]
xref: BTO:0004778
is_a: CL:2000029 ! central nervous system neuron
relationship: part_of UBERON:0000369 ! corpus striatum

[Term]
id: CL:1001502
name: mitral cell
namespace: cl
def: "the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [MP:0009954]
is_a: CL:1001434 ! olfactory bulb interneuron
relationship: part_of UBERON:0004186 ! olfactory bulb mitral cell layer

[Term]
id: CL:1001503
name: olfactory bulb tufted cell
namespace: cl
def: "the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala" [MP:0009955]
is_a: CL:2000029 ! central nervous system neuron
relationship: part_of UBERON:0005376 ! olfactory bulb external plexiform layer

[Term]
id: CL:1001505
name: parvocellular neurosecretory cell
namespace: cl
def: "the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system" [MP:0010125]
synonym: "parvocellular neuron" EXACT []
synonym: "parvocellular neurosecretory neuron" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000381 ! neurosecretory neuron
is_a: CL:2000029 ! central nervous system neuron
is_a: CL:2000030 ! hypothalamus native cell
relationship: capable_of GO:0030103 ! vasopressin secretion
relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus

[Term]
id: CL:1001509
name: glycinergic neuron
namespace: cl
def: "the neurons that utilize glycine as a neurotransmitter" [MP:0010385]
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061537 ! glycine secretion, neurotransmission
relationship: capable_of GO:0061537 ! glycine secretion, neurotransmission

[Term]
id: CL:1001516
name: intestinal enteroendocrine cell
namespace: cl
def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MP:0010802]
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001242 ! intestinal mucosa
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: CL:1001517
name: stomach enteroendocrine cell
namespace: cl
def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MP:0010803]
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach

[Term]
id: CL:1001561
name: vomeronasal sensory neuron
namespace: cl
def: "chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MP:0011679]
is_a: CARO:0001001 ! neuron projection bundle
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: innervates UBERON:0003367 ! epithelium of vomeronasal organ
intersection_of: part_of UBERON:0002255 ! vomeronasal organ
relationship: innervates UBERON:0003367 ! epithelium of vomeronasal organ
relationship: part_of UBERON:0002255 ! vomeronasal organ

[Term]
id: CL:1001566
name: bronchioalveolar stem cells
namespace: cl
def: "a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury." [MP:0011691]
is_a: CL:0000034 ! stem cell
relationship: part_of UBERON:0000115 ! lung epithelium

[Term]
id: CL:1001567
name: lung endothelial cell
namespace: cl
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000102 ! lung vasculature
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
namespace: cl
synonym: "PAEC cell" RELATED [BTO:0001141]
xref: BTO:0001141
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0005317 ! pulmonary artery endothelium

[Term]
id: CL:1001569
name: hippocampal interneuron
namespace: cl
def: "An interneuron of the hippocampus." [GOC:pr]
xref: FMA:84777
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn

[Term]
id: CL:1001571
name: hippocampal pyramidal neuron
namespace: cl
def: "A pyramidal neuron of the hippocampus." [GOC:pr, PMID:19342486]
synonym: "hippocampus (CA) pyramidal cell" EXACT [NIFSTD:sao131261273]
synonym: "hippocampus (CA) pyramidal neuron" EXACT [NIFSTD:sao131261273]
xref: NIFSTD:sao131261273
xref: SAO:sao131261273
is_a: CL:0002608 ! hippocampal neuron
is_a: CL:2000056 ! Meynert cell
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0002313 ! hippocampus pyramidal layer

[Term]
id: CL:1001572
name: colon endothelial cell
def: "Vascular endothelium found in colon blood vessels." [NPX:PDR]
synonym: "colon endothelial cells" RELATED PLURAL [CALOHA:TS-2397]
synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397]
xref: CALOHA:TS-2397
is_a: CL:0000115 ! endothelial cell
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0013695 ! colon endothelium

[Term]
id: CL:1001573
name: nasopharyngeal epithelial cell
def: "Cell of the nasopharyngeal epithelium." [NPX:PDR]
synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398]
xref: CALOHA:TS-2398
is_a: CL:0002251 ! epithelial cell of alimentary canal
is_a: CL:0002631 ! epithelial cell of upper respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001951 ! epithelium of nasopharynx

[Term]
id: CL:1001575
name: uterine cervix squamous cell
def: "Squamous cell of uterine cervix epithelium." [NPX:PDR]
synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251]
synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251]
synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251]
synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251]
synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251]
xref: CALOHA:TS-1251
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002535 ! epithelial cell of cervix
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0004801 ! cervix epithelium

[Term]
id: CL:1001576
name: oral mucosa squamous cell
def: "Squamous cell of oral epithelium." [NPX:PDR]
synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252]
synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252]
xref: CALOHA:TS-1252
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0002424 ! oral epithelium
relationship: part_of UBERON:0002424 ! oral epithelium

[Term]
id: CL:1001577
name: tonsil squamous cell
def: "Squamous cell of tonsil epithelium." [NPX:PDR]
synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253]
synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253]
synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253]
synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253]
xref: CALOHA:TS-1253
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0013696 ! tonsil epithelium

[Term]
id: CL:1001578
name: vagina squamous cell
def: "Squamous cell of vaginal epithelium." [NPX:PDR]
synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254]
synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254]
synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254]
synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254]
xref: CALOHA:TS-1254
is_a: CL:0000076 ! squamous epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0001344 ! epithelium of vagina

[Term]
id: CL:1001579
name: cerebral cortex glial cell
def: "Glial cell of cerebral cortex." [NPX:PDR]
synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256]
synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256]
synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256]
xref: CALOHA:TS-1256
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: CL:1001580
name: hippocampus glial cell
def: "Glial cell of hippocampus." [NPX:PDR]
synonym: "hippocampal glial cell" RELATED [CALOHA:TS-1257]
synonym: "hippocampus glial cells" RELATED [CALOHA:TS-1257]
synonym: "hippocampus neuroglial cell" RELATED [CALOHA:TS-1257]
xref: CALOHA:TS-1257
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn

[Term]
id: CL:1001581
name: lateral ventricle glial cell
def: "Glial cell of lateral ventricle." [NPX:PDR]
synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258]
xref: CALOHA:TS-1258
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle

[Term]
id: CL:1001582
name: lateral ventricle neuron
def: "Neuron of lateral ventricle." [NPX:PDR]
synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261]
xref: CALOHA:TS-1261
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle

[Term]
id: CL:1001583
name: obsolete breast adipocyte
def: "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." [HPA:Breast]
synonym: "breast adipocytes" RELATED [CALOHA:TS-2377]
is_obsolete: true
replaced_by: CL:0002617

[Term]
id: CL:1001585
name: appendix glandular cell
def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271]
synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271]
synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271]
synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271]
xref: CALOHA:TS-1271
is_a: CL:1000405 ! epithelial cell of appendix
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0009697 ! epithelium of appendix

[Term]
id: CL:1001586
name: mammary gland glandular cell
def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [NPX:PDR;HPA\:HPA]
synonym: "breast glandular cell" RELATED [CALOHA:TS-1272]
synonym: "breast glandular cells" RELATED [CALOHA:TS-1272]
synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272]
xref: CALOHA:TS-1272
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002327 ! mammary gland epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0003244 ! epithelium of mammary gland

[Term]
id: CL:1001587
name: uterine cervix glandular cell
def: "Glandular cell of uterine cervix epithelium." [NPX:PDR]
synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273]
synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273]
synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273]
xref: CALOHA:TS-1273
is_a: CL:0002535 ! epithelial cell of cervix
is_a: CL:1001591 ! oviduct glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0004801 ! cervix epithelium

[Term]
id: CL:1001588
name: colon glandular cell
def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "colon glandular cells" RELATED [CALOHA:TS-1274]
xref: CALOHA:TS-1274
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0000397 ! colonic epithelium
relationship: part_of UBERON:0001155 ! colon

[Term]
id: CL:1001589
name: duodenum glandular cell
def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR]
synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275]
xref: CALOHA:TS-1275
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008346 ! duodenal epithelium

[Term]
id: CL:1001590
name: epididymis glandular cell
def: "Glandular cell of epididymal epithelium." [NPX:PDR]
synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276]
synonym: "epididymis glandular cells" RELATED [CALOHA:TS-1276]
xref: CALOHA:TS-1276
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0004544 ! epididymis epithelium

[Term]
id: CL:1001591
name: oviduct glandular cell
def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [NPX:PDR;HPA\:HPA]
synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277]
synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277]
synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277]
xref: CALOHA:TS-1277
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0004804 ! oviduct epithelium

[Term]
id: CL:1001592
name: gall bladder glandular cell
def: "Glandular cell of gall bladder epithelium." [NPX:PDR]
synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278]
synonym: "gallbladder glandular cell" RELATED [CALOHA:TS-1278]
synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278]
xref: CALOHA:TS-1278
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:1000415 ! epithelial cell of gall bladder
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002029 ! epithelium of gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: CL:1001593
name: parathyroid glandular cell
def: "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." [NPX:PDR;HPA\:HPA]
synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279]
synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279]
xref: CALOHA:TS-1279
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: part_of UBERON:0001132 ! parathyroid gland
relationship: part_of UBERON:0011197 ! parathyroid epithelium

[Term]
id: CL:1001595
name: rectum glandular cell
def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281]
synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281]
xref: CALOHA:TS-1281
is_a: CL:0002658 ! glandular cell of the large intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0003354 ! epithelium of rectum

[Term]
id: CL:1001596
name: salivary gland glandular cell
def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [NPX:PDR;HPA\:HPA]
synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282]
xref: CALOHA:TS-1282
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0004809 ! salivary gland epithelium

[Term]
id: CL:1001597
name: seminal vesicle glandular cell
def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR]
synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283]
xref: CALOHA:TS-1283
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0004805 ! seminal vesicle epithelium

[Term]
id: CL:1001598
name: small intestine glandular cell
def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell;NPX\:PDR]
synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286]
synonym: "small intestinal glandular cell" RELATED [CALOHA:TS-1286]
synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286]
xref: CALOHA:TS-1286
xref: FMA:86928
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: CL:1001599
name: pancreas exocrine glandular cell
def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [NPX:PDR;HPA\:HPA]
synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242]
synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242]
xref: BTO:0000028
xref: CALOHA:TS-1242
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium

[Term]
id: CL:1001601
name: adrenal gland glandular cell
def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [NPX:PDR]
synonym: "adrenal gland glandular cells" RELATED [CALOHA:TS-2177]
synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177]
synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177]
xref: CALOHA:TS-2177
is_a: CL:0000150 ! glandular epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: part_of UBERON:0001235 ! adrenal cortex

[Term]
id: CL:1001602
name: cerebral cortex endothelial cell
def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." [NPX:PDR]
synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372]
synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372]
xref: CALOHA:TS-2372
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0013694 ! brain endothelium

[Term]
id: CL:1001603
name: lung macrophage
def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [NPX:PDR;HPA\:HPA]
synonym: "lung macrophages" RELATED [CALOHA:TS-0576]
xref: CALOHA:TS-0576
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1001606
name: foreskin keratinocyte
def: "Keratinocyte from foreskin." [NPX:PDR]
xref: CALOHA:TS-0385
is_a: CL:0000312 ! keratinocyte
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis

[Term]
id: CL:1001607
name: articular chondrocyte
def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR]
xref: CALOHA:TS-0056
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0010996 ! articular cartilage of joint
relationship: part_of UBERON:0010996 ! articular cartilage of joint

[Term]
id: CL:1001608
name: foreskin fibroblast
def: "Fibroblast from foreskin." [NPX:PDR]
synonym: "BJ fibroblast" EXACT []
xref: CALOHA:TS-0384
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis

[Term]
id: CL:1001609
name: muscle fibroblast
def: "Fibroblast from muscle organ." [NPX:PDR]
xref: CALOHA:TS-0643
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0001630 ! muscle organ

[Term]
id: CL:1001610
name: bone marrow hematopoietic cell
def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR]
synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109]
synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109]
xref: CALOHA:TS-2109
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0012429 ! hemopoietic tissue

[Term]
id: CL:1001611
name: cerebellar neuron
def: "Neuron of the cerebellum." [NPX:PDR]
synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359]
xref: CALOHA:TS-2359
xref: FMA:84665
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: CL:2000000
name: epidermal melanocyte
namespace: cell
def: "Any melanocyte that is part of a epidermis." [GOC:TermGenie]
comment: These cells are found primarily, but not exclusively, in primates including humans
is_a: CL:0002484 ! epithelial melanocyte
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis
created_by: TermGenie
creation_date: 2014-02-03T23:03:09Z

[Term]
id: CL:2000001
name: peripheral blood mononuclear cell
namespace: cell
def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie]
is_a: CL:0000080 ! circulating cell
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0000178 ! blood
relationship: part_of UBERON:0000178 ! blood
created_by: TermGenie
creation_date: 2014-02-11T17:29:04Z

[Term]
id: CL:2000002
name: decidua cell
namespace: cell
def: "Any native cell that is part of a decidua." [GOC:TermGenie]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0002450 ! decidua
relationship: part_of UBERON:0002450 ! decidua
created_by: TermGenie
creation_date: 2014-02-20T23:06:41Z

[Term]
id: CL:2000004
name: pituitary gland cell
namespace: cell
def: "Any cell that is part of a pituitary gland." [GOC:TermGenie]
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0000007 ! pituitary gland
relationship: part_of UBERON:0000007 ! pituitary gland
created_by: TermGenie
creation_date: 2014-03-26T22:14:56Z

[Term]
id: CL:2000005
name: brain macroglial cell
namespace: cell
def: "Any macroglial cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0000126 ! macroglial cell
intersection_of: CL:0000126 ! macroglial cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
created_by: TermGenie
creation_date: 2014-03-28T21:35:27Z

[Term]
id: CL:2000006
name: tonsil germinal center B cell
namespace: cell
def: "Any germinal center B cell that is part of a tonsil." [GOC:TermGenie]
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil
created_by: TermGenie
creation_date: 2014-03-28T21:35:33Z

[Term]
id: CL:2000007
name: articular chondrocyte of knee joint
namespace: cell
def: "Chondrocyte forming the hyaline cartilage found in the knee joint." [GOC:TermGenie]
is_a: CL:1001607 ! articular chondrocyte
intersection_of: CL:1001607 ! articular chondrocyte
intersection_of: part_of UBERON:0001485 ! knee joint
relationship: part_of UBERON:0001485 ! knee joint
created_by: TermGenie
creation_date: 2014-06-04T14:40:11Z

[Term]
id: CL:2000008
name: microvascular endothelial cell
namespace: cell
def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: part_of UBERON:0008339 ! microvascular endothelium
created_by: TermGenie
creation_date: 2014-06-04T15:07:42Z

[Term]
id: CL:2000009
name: obsolete microvascular endothelium blood vessel endothelial cell
namespace: cell
def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
is_obsolete: true
replaced_by: CL:2000008
created_by: TermGenie
creation_date: 2014-06-04T15:09:18Z

[Term]
id: CL:2000010
name: dermis blood vessel endothelial cell
namespace: cell
def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie]
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
created_by: TermGenie
creation_date: 2014-06-04T15:12:06Z

[Term]
id: CL:2000011
name: dermis lymphatic vessel endothelial cell
namespace: cell
def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [GOC:TermGenie]
is_a: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
created_by: TermGenie
creation_date: 2014-06-04T15:15:08Z

[Term]
id: CL:2000012
name: fibroblast of pedal digit skin
namespace: cell
def: "Any skin fibroblast that is part of a pedal digit skin." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0003530 ! pedal digit skin
relationship: part_of UBERON:0003530 ! pedal digit skin
created_by: TermGenie
creation_date: 2014-06-04T15:16:44Z

[Term]
id: CL:2000013
name: fibroblast of skin of abdomen
namespace: cell
def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001416 ! skin of abdomen
relationship: part_of UBERON:0001416 ! skin of abdomen
created_by: TermGenie
creation_date: 2014-06-04T15:18:16Z

[Term]
id: CL:2000014
name: fibroblast of upper leg skin
namespace: cell
def: "Any skin fibroblast that is part of a upper leg skin." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0004262 ! upper leg skin
relationship: part_of UBERON:0004262 ! upper leg skin
created_by: TermGenie
creation_date: 2014-06-04T15:19:44Z

[Term]
id: CL:2000015
name: fibroblast of arm
namespace: cell
def: "Any skin fibroblast that is part of a arm." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm
created_by: TermGenie
creation_date: 2014-06-04T15:29:06Z

[Term]
id: CL:2000016
name: lung microvascular endothelial cell
namespace: cell
def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
is_a: CL:1001567 ! lung endothelial cell
intersection_of: CL:1001567 ! lung endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: part_of UBERON:0008339 ! microvascular endothelium
created_by: TermGenie
creation_date: 2014-06-04T16:00:56Z

[Term]
id: CL:2000017
name: fibroblast of peridontal ligament
namespace: cell
def: "Any fibroblast that is part of a periodontal ligament." [GOC:TermGenie]
is_a: CL:0002556 ! fibroblast of periodontium
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0008266 ! periodontal ligament
relationship: part_of UBERON:0008266 ! periodontal ligament
created_by: TermGenie
creation_date: 2014-06-04T16:50:33Z

[Term]
id: CL:2000018
name: endothelial cell of coronary artery
namespace: cell
def: "Any endothelial cell of artery that is part of a coronary artery." [GOC:TermGenie]
is_a: CL:0010006 ! cardiac blood vessel endothelial cell
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: part_of UBERON:0001621 ! coronary artery
relationship: part_of UBERON:0001621 ! coronary artery
created_by: TermGenie
creation_date: 2014-06-04T17:08:47Z

[Term]
id: CL:2000019
name: compound eye photoreceptor cell
namespace: cell
def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie]
is_a: CL:0000287 ! eye photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000018 ! compound eye
relationship: part_of UBERON:0000018 ! compound eye
created_by: TermGenie
creation_date: 2014-06-24T23:16:45Z

[Term]
id: CL:2000020
name: inner cell mass native cell
namespace: cell
def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0000087 ! inner cell mass
relationship: part_of UBERON:0000087 ! inner cell mass
created_by: TermGenie
creation_date: 2014-06-24T23:16:53Z

[Term]
id: CL:2000021
name: sebaceous gland native cell
namespace: cell
def: "Any native cell that is part of a sebaceous gland." [GOC:TermGenie]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0001821 ! sebaceous gland
created_by: TermGenie
creation_date: 2014-06-24T23:17:00Z

[Term]
id: CL:2000022
name: cardiac septum native cell
namespace: cell
def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie]
is_a: CL:0000003 ! native cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0002099 ! cardiac septum
relationship: part_of UBERON:0002099 ! cardiac septum
created_by: TermGenie
creation_date: 2014-06-24T23:17:07Z

[Term]
id: CL:2000023
name: spinal cord ventral column interneuron
namespace: cell
def: "Any interneuron that is part of a spinal cord ventral column." [GOC:TermGenie]
is_a: CL:0005000 ! spinal cord interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: part_of UBERON:0005375 ! spinal cord ventral column
relationship: part_of UBERON:0005375 ! spinal cord ventral column
created_by: TermGenie
creation_date: 2014-06-25T00:23:36Z

[Term]
id: CL:2000024
name: spinal cord medial motor column neuron
namespace: cell
def: "Any neuron that is part of a spinal cord medial motor column." [GOC:TermGenie]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0004059 ! spinal cord medial motor column
relationship: part_of UBERON:0004059 ! spinal cord medial motor column
created_by: TermGenie
creation_date: 2014-06-25T00:23:43Z

[Term]
id: CL:2000025
name: spinal cord oligodendrocyte
namespace: cell
def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie]
is_a: CL:0000128 ! oligodendrocyte
intersection_of: CL:0000128 ! oligodendrocyte
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord
created_by: TermGenie
creation_date: 2014-06-25T00:23:50Z

[Term]
id: CL:2000026
name: obsolete cerebellum Golgi cell
namespace: cell
def: "Any Golgi cell that is part of a cerebellum." [GOC:TermGenie]
is_obsolete: true
created_by: TermGenie
creation_date: 2014-06-25T00:23:57Z

[Term]
id: CL:2000027
name: cerebellum basket cell
namespace: cell
def: "Any basket cell that is part of a cerebellum." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000118 ! basket cell
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
created_by: TermGenie
creation_date: 2014-06-25T00:24:03Z

[Term]
id: CL:2000028
name: cerebellum glutamatergic neuron
namespace: cell
def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie]
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
created_by: TermGenie
creation_date: 2014-06-25T00:24:10Z

[Term]
id: CL:2000029
name: central nervous system neuron
namespace: cell
def: "Any neuron that is part of a central nervous system." [GOC:TermGenie]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system
created_by: TermGenie
creation_date: 2014-06-25T01:17:43Z

[Term]
id: CL:2000030
name: hypothalamus native cell
namespace: cell
def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie]
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000003 ! native cell
intersection_of: part_of UBERON:0001898 ! hypothalamus
relationship: part_of UBERON:0001898 ! hypothalamus
created_by: TermGenie
creation_date: 2014-06-25T01:17:50Z

[Term]
id: CL:2000031
name: lateral line ganglion neuron
namespace: cell
def: "Any neuron that is part of a lateral line ganglion." [GOC:TermGenie]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:2000120 ! lateral line ganglion
relationship: part_of UBERON:2000120 ! lateral line ganglion
created_by: TermGenie
creation_date: 2014-06-25T01:17:57Z

[Term]
id: CL:2000032
name: peripheral nervous system neuron
namespace: cell
def: "Any neuron that is part of a peripheral nervous system." [GOC:TermGenie]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0000010 ! peripheral nervous system
relationship: part_of UBERON:0000010 ! peripheral nervous system
created_by: TermGenie
creation_date: 2014-06-25T02:28:17Z

[Term]
id: CL:2000033
name: limb basal cell of epidermis
namespace: cell
def: "Any basal cell of epidermis that is part of a limb." [GOC:TermGenie]
is_a: CL:0002187 ! basal cell of epidermis
intersection_of: CL:0002187 ! basal cell of epidermis
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb
created_by: TermGenie
creation_date: 2014-06-25T02:28:25Z

[Term]
id: CL:2000034
name: anterior lateral line neuromast hair cell
namespace: cell
def: "Any neuromast hair cell that is part of a anterior lateral line." [GOC:TermGenie]
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: part_of UBERON:2001470 ! anterior lateral line
relationship: part_of UBERON:2001470 ! anterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:44:37Z

[Term]
id: CL:2000035
name: anterior lateral line neuromast mantle cell
namespace: cell
def: "Any neuromast mantle cell that is part of a anterior lateral line." [GOC:TermGenie]
is_a: CL:0000851 ! neuromast mantle cell
intersection_of: CL:0000851 ! neuromast mantle cell
intersection_of: part_of UBERON:2001470 ! anterior lateral line
relationship: part_of UBERON:2001470 ! anterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:44:44Z

[Term]
id: CL:2000036
name: anterior lateral line neuromast support cell
namespace: cell
def: "Any neuromast support cell that is part of a anterior lateral line." [GOC:TermGenie]
is_a: CL:0000852 ! neuromast support cell
intersection_of: CL:0000852 ! neuromast support cell
intersection_of: part_of UBERON:2001470 ! anterior lateral line
relationship: part_of UBERON:2001470 ! anterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:44:51Z

[Term]
id: CL:2000037
name: posterior lateral line neuromast hair cell
namespace: cell
def: "Any neuromast hair cell that is part of a posterior lateral line." [GOC:TermGenie]
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: part_of UBERON:0006334 ! posterior lateral line
relationship: part_of UBERON:0006334 ! posterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:44:57Z

[Term]
id: CL:2000038
name: posterior lateral line neuromast mantle cell
namespace: cell
def: "Any neuromast mantle cell that is part of a posterior lateral line." [GOC:TermGenie]
is_a: CL:0000851 ! neuromast mantle cell
intersection_of: CL:0000851 ! neuromast mantle cell
intersection_of: part_of UBERON:0006334 ! posterior lateral line
relationship: part_of UBERON:0006334 ! posterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:45:04Z

[Term]
id: CL:2000039
name: posterior lateral line neuromast support cell
namespace: cell
def: "Any neuromast support cell that is part of a posterior lateral line." [GOC:TermGenie]
is_a: CL:0000852 ! neuromast support cell
intersection_of: CL:0000852 ! neuromast support cell
intersection_of: part_of UBERON:0006334 ! posterior lateral line
relationship: part_of UBERON:0006334 ! posterior lateral line
created_by: TermGenie
creation_date: 2014-06-25T03:45:11Z

[Term]
id: CL:2000040
name: bladder microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie]
is_a: CL:1001319 ! bladder cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
created_by: TermGenie
creation_date: 2014-07-09T00:04:47Z

[Term]
id: CL:2000041
name: dermis microvascular lymphatic vessel endothelial cell
namespace: cell
def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell
intersection_of: CL:2000011 ! dermis lymphatic vessel endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: part_of UBERON:0008339 ! microvascular endothelium
created_by: TermGenie
creation_date: 2014-07-09T00:09:54Z

[Term]
id: CL:2000042
name: embryonic fibroblast
namespace: cell
def: "Any fibroblast that is part of a embryo." [GOC:TermGenie]
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
created_by: TermGenie
creation_date: 2014-07-09T00:12:00Z

[Term]
id: CL:2000043
name: brain pericyte
namespace: cell
def: "Any pericyte cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0002575 ! central nervous system pericyte
intersection_of: CL:0000669 ! pericyte cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
created_by: TermGenie
creation_date: 2014-07-09T00:18:22Z

[Term]
id: CL:2000044
name: brain microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0002319 ! neural cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
created_by: TermGenie
creation_date: 2014-07-09T00:24:53Z

[Term]
id: CL:2000045
name: foreskin melanocyte
namespace: cell
def: "Any melanocyte that is part of a prepuce of penis." [GOC:TermGenie]
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis
created_by: TermGenie
creation_date: 2014-07-09T00:45:07Z

[Term]
id: CL:2000046
name: ventricular cardiac muscle cell
namespace: cell
def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie]
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
created_by: TermGenie
creation_date: 2014-08-12T20:50:28Z

[Term]
id: CL:2000047
name: brainstem motor neuron
namespace: cell
def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie]
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0002298 ! brainstem
created_by: TermGenie
creation_date: 2014-10-02T23:52:53Z

[Term]
id: CL:2000048
name: ventral horn of spinal cord spinal cord motor neuron
namespace: cell
def: "Any spinal cord motor neuron that is part of a ventral horn of spinal cord." [GOC:TermGenie]
is_a: CL:0011001 ! spinal cord motor neuron
intersection_of: CL:0011001 ! spinal cord motor neuron
intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord
relationship: part_of UBERON:0002257 ! ventral horn of spinal cord
created_by: TermGenie
creation_date: 2014-10-03T00:26:27Z

[Term]
id: CL:2000049
name: primary motor cortex pyramidal cell
namespace: cell
def: "Any pyramidal cell that is part of a primary motor cortex." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/pubmed/12524689
is_a: CL:2000056 ! Meynert cell
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: part_of UBERON:0001384 ! primary motor cortex
relationship: part_of UBERON:0001384 ! primary motor cortex
created_by: TermGenie
creation_date: 2014-10-06T17:39:04Z

[Term]
id: CL:2000050
name: obsolete retina retinal ganglion cell
namespace: cell
def: "Any retinal ganglion cell that is part of a retina." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/pubmed/2889210
is_obsolete: true
created_by: TermGenie
creation_date: 2014-10-06T17:43:59Z

[Term]
id: CL:2000051
name: splenic fibroblast
namespace: cell
def: "Any fibroblast that is part of a spleen." [GOC:TermGenie]
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
created_by: TermGenie
creation_date: 2014-10-06T18:58:47Z

[Term]
id: CL:2000052
name: umbilical artery endothelial cell
namespace: cell
def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord
created_by: TermGenie
creation_date: 2014-10-06T19:01:48Z

[Term]
id: CL:2000053
name: splenic endothelial cell
namespace: cell
def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
created_by: TermGenie
creation_date: 2014-10-06T19:06:04Z

[Term]
id: CL:2000054
name: hepatic pit cell
namespace: cell
def: "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." [GOC:dos, PMID:9408963]
comment: Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit.
is_a: CL:0000623 ! natural killer cell
relationship: has_part GO:0030141 ! secretory granule
relationship: located_in UBERON:0001281 ! hepatic sinusoid
creation_date: 2014-10-06T19:08:51Z

[Term]
id: CL:2000055
name: liver dendritic cell
namespace: cell
def: "Any dendritic cell that is part of a liver." [GOC:TermGenie]
comment: http://www.jleukbio.org/content/66/2/322.abstract
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
created_by: TermGenie
creation_date: 2014-10-06T19:16:11Z

[Term]
id: CL:2000056
name: Meynert cell
namespace: cell
def: "Any pyramidal cell that is part of a regional part of cerebral cortex." [GOC:TermGenie]
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
created_by: TermGenie
creation_date: 2014-10-06T19:20:41Z

[Term]
id: CL:2000057
name: femural osteoblast
namespace: cell
def: "Any osteoblast that is part of a femur." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4610
is_a: CL:0000062 ! osteoblast
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000062 ! osteoblast
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
created_by: TermGenie
creation_date: 2014-10-06T19:29:45Z

[Term]
id: CL:2000058
name: calvarial osteoblast
namespace: cell
def: "Any osteoblast that is part of a skull." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4600
is_a: CL:0000062 ! osteoblast
intersection_of: CL:0000062 ! osteoblast
intersection_of: part_of UBERON:0003129 ! skull
relationship: part_of UBERON:0003129 ! skull
created_by: TermGenie
creation_date: 2014-10-06T19:48:30Z

[Term]
id: CL:2000059
name: prostate gland microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
created_by: TermGenie
creation_date: 2014-10-07T17:46:27Z

[Term]
id: CL:2000060
name: placental villous trophoblast
namespace: cell
def: "Any trophoblast cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7120
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: TermGenie
creation_date: 2014-10-07T17:48:27Z

[Term]
id: CL:2000061
name: placental amniotic mesenchymal stromal cell
namespace: cell
def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: TermGenie
creation_date: 2014-10-07T17:51:11Z

[Term]
id: CL:2000062
name: placental villus capillary endothelial cell
namespace: cell
def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:0002577 ! placental epithelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: TermGenie
creation_date: 2014-10-07T17:55:56Z

[Term]
id: CL:2000063
name: ovarian fibroblast
namespace: cell
def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad
created_by: TermGenie
creation_date: 2014-10-07T17:57:42Z

[Term]
id: CL:2000064
name: ovarian surface epithelial cell
namespace: cell
def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad
created_by: TermGenie
creation_date: 2014-10-07T17:59:13Z

[Term]
id: CL:2000065
name: ovarian microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300
is_a: CL:1000296 ! epithelial cell of urethra
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: part_of UBERON:0001334 ! female urethra
created_by: TermGenie
creation_date: 2014-10-07T18:18:01Z

[Term]
id: CL:2000066
name: cardiac ventricle fibroblast
namespace: cell
def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
created_by: TermGenie
creation_date: 2014-10-07T18:35:38Z

[Term]
id: CL:2000067
name: cardiac atrium fibroblast
namespace: cell
def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium
created_by: TermGenie
creation_date: 2014-10-07T18:36:54Z

[Term]
id: CL:2000068
name: pericardium fibroblast
namespace: cell
def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002407 ! pericardium
relationship: part_of UBERON:0002407 ! pericardium
created_by: TermGenie
creation_date: 2014-10-07T18:38:06Z

[Term]
id: CL:2000069
name: gallbladder fibroblast
namespace: cell
def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder
created_by: TermGenie
creation_date: 2014-10-07T18:41:43Z

[Term]
id: CL:2000070
name: optic choroid fibroblast
namespace: cell
def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001776 ! optic choroid
created_by: TermGenie
creation_date: 2014-10-07T18:50:43Z

[Term]
id: CL:2000071
name: mammary microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a breast." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7600
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0000310 ! breast
relationship: part_of UBERON:0000310 ! breast
created_by: TermGenie
creation_date: 2014-10-07T19:55:30Z

[Term]
id: CL:2000072
name: adipose microvascular endothelial cell
namespace: cell
def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200
is_a: CL:0002320 ! connective tissue cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: part_of UBERON:0001013 ! adipose tissue
created_by: TermGenie
creation_date: 2014-10-07T22:13:45Z

[Term]
id: CL:2000073
name: migratory cardiac neural crest cell
namespace: cell
def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie]
is_a: CL:0000333 ! migratory neural crest cell
intersection_of: CL:0000333 ! migratory neural crest cell
intersection_of: part_of UBERON:0000095 ! cardiac neural crest
relationship: part_of UBERON:0000095 ! cardiac neural crest
created_by: TermGenie
creation_date: 2014-11-05T01:18:43Z

[Term]
id: CL:2000074
name: splenocyte
namespace: cell
def: "Any leukocyte that is part of a spleen." [GOC:TermGenie]
comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology.
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
created_by: TermGenie
creation_date: 2014-11-05T01:26:50Z

[Term]
id: CL:2000075
name: anterior visceral endoderm cell
namespace: cell
def: "Any endodermal cell that is part of a anterior visceral endoderm." [GOC:TermGenie]
is_a: CL:0000223 ! endodermal cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000223 ! endodermal cell
intersection_of: part_of UBERON:0004044 ! anterior visceral endoderm
relationship: part_of UBERON:0004044 ! anterior visceral endoderm
created_by: TermGenie
creation_date: 2014-11-05T01:34:13Z

[Term]
id: CL:2000076
name: hindlimb stylopod vein endothelial cell
namespace: cell
def: "Any vein endothelial cell that is part of a hindlimb stylopod." [GOC:TermGenie]
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod
created_by: TermGenie
creation_date: 2014-12-02T18:40:47Z

[Term]
id: CL:2000077
name: skeletal muscle tissue of pectoralis major striated muscle cell
namespace: cell
def: "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." [GOC:TermGenie]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000737 ! striated muscle cell
intersection_of: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major
relationship: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major
created_by: TermGenie
creation_date: 2014-12-02T18:48:17Z

[Term]
id: CL:2000078
name: placental pericyte
namespace: cell
def: "Any pericyte cell that is part of a placenta." [GOC:TermGenie]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000669 ! pericyte cell
intersection_of: CL:0000669 ! pericyte cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
created_by: TermGenie
creation_date: 2014-12-02T18:51:03Z

[Term]
id: CL:2000079
name: mesenchymal stem cell of femoral bone marrow
namespace: cell
def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [GOC:TermGenie]
is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow
intersection_of: CL:0002540 ! mesenchymal stem cell of the bone marrow
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
created_by: TermGenie
creation_date: 2014-12-02T19:07:31Z

[Term]
id: CL:2000080
name: mesenchymal stem cell of abdominal adipose
namespace: cell
def: "Any mesenchymal stem cell of adipose that is part of a abdomen." [GOC:TermGenie]
is_a: CL:0002570 ! mesenchymal stem cell of adipose
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen
created_by: TermGenie
creation_date: 2014-12-02T19:10:34Z

[Term]
id: CL:2000081
name: melanocyte of skin of face
namespace: cell
def: "Any melanocyte of skin that is part of a skin of face." [GOC:TermGenie]
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:1000458 ! melanocyte of skin
intersection_of: part_of UBERON:1000021 ! skin of face
relationship: part_of UBERON:1000021 ! skin of face
created_by: TermGenie
creation_date: 2014-12-02T19:10:40Z

[Term]
id: CL:2000082
name: melanocyte of foreskin
namespace: cell
def: "Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie]
is_a: CL:1000458 ! melanocyte of skin
is_a: CL:2000045 ! foreskin melanocyte
intersection_of: CL:1000458 ! melanocyte of skin
intersection_of: part_of UBERON:0001471 ! skin of prepuce of penis
relationship: part_of UBERON:0001471 ! skin of prepuce of penis
created_by: TermGenie
creation_date: 2014-12-02T19:10:45Z

[Term]
id: CL:2000083
name: hair follicle dermal papilla cell of scalp
namespace: cell
def: "Any hair follicle dermal papilla cell that is part of a scalp." [GOC:TermGenie]
is_a: CL:0000346 ! hair follicle dermal papilla cell
intersection_of: CL:0000346 ! hair follicle dermal papilla cell
intersection_of: part_of UBERON:0000403 ! scalp
relationship: part_of UBERON:0000403 ! scalp
created_by: TermGenie
creation_date: 2014-12-02T19:10:50Z

[Term]
id: CL:2000084
name: conjunctiva goblet cell
namespace: cell
def: "Any goblet cell that is part of a conjunctiva." [GOC:TermGenie]
is_a: CL:0000160 ! goblet cell
is_a: CL:1000432 ! conjunctival epithelial cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva
created_by: TermGenie
creation_date: 2014-12-02T19:28:38Z

[Term]
id: CL:2000085
name: mononuclear cell of umbilical cord
namespace: cell
def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord
created_by: TermGenie
creation_date: 2014-12-02T20:14:16Z

[Term]
id: CL:2000086
name: neocortex basket cell
namespace: cell
def: "Any basket cell that is part of a neocortex." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000118 ! basket cell
intersection_of: part_of UBERON:0001950 ! neocortex
relationship: part_of UBERON:0001950 ! neocortex
created_by: TermGenie
creation_date: 2014-12-24T00:37:19Z

[Term]
id: CL:2000087
name: dentate gyrus of hippocampal formation basket cell
namespace: cell
def: "Any basket cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000118 ! basket cell
intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
created_by: TermGenie
creation_date: 2014-12-24T00:37:24Z

[Term]
id: CL:2000088
name: Ammon's horn basket cell
namespace: cell
def: "Any basket cell that is part of a Ammon's horn." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000118 ! basket cell
intersection_of: part_of UBERON:0001954 ! Ammon's horn
relationship: part_of UBERON:0001954 ! Ammon's horn
created_by: TermGenie
creation_date: 2014-12-24T00:37:30Z

[Term]
id: CL:2000089
name: dentate gyrus of hippocampal formation granule cell
namespace: cell
def: "The principal cell type of the dentate gyrus." [GOC:TermGenie]
comment: The granule cell has a characteristic cone-shaped tree of spiny apical dendrites.
is_a: CL:0001032 ! cortical granule cell
intersection_of: CL:0000120 ! granule cell
intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
created_by: TermGenie
creation_date: 2015-02-23T05:48:23Z

[Term]
id: CL:2000090
name: dentate gyrus of hippocampal formation stellate cell
namespace: cell
def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie]
is_a: CL:0000122 ! stellate neuron
is_a: CL:0002609 ! neuron of cerebral cortex
intersection_of: CL:0000122 ! stellate neuron
intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
created_by: TermGenie
creation_date: 2015-02-23T05:48:40Z

[Term]
id: CL:2000091
name: endometrial microvascular endothelial cells
namespace: cell
def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie]
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0015172 ! endometrial blood vessel
relationship: part_of UBERON:0015172 ! endometrial blood vessel
created_by: TermGenie
creation_date: 2015-03-31T21:02:36Z

[Term]
id: CL:2000092
name: hair follicular keratinocyte
namespace: cell
def: "Any keratinocyte that is part of a hair follicle." [GOC:TermGenie]
is_a: CL:0000312 ! keratinocyte
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0002073 ! hair follicle
created_by: TermGenie
creation_date: 2015-03-31T21:07:02Z

[Term]
id: CL:2000093
name: bronchus fibroblast of lung
namespace: cell
def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie]
is_a: CL:0002553 ! fibroblast of lung
intersection_of: CL:0002553 ! fibroblast of lung
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus
created_by: TermGenie
creation_date: 2015-03-31T21:16:22Z

[Term]
id: CL:2000094
name: nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa
namespace: cell
def: "Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium." [GOC:TermGenie]
is_a: CL:1000441 ! epithelial cell of viscerocranial mucosa
intersection_of: CL:1000441 ! epithelial cell of viscerocranial mucosa
intersection_of: part_of UBERON:0005385 ! nasal cavity respiratory epithelium
relationship: part_of UBERON:0005385 ! nasal cavity respiratory epithelium
created_by: TermGenie
creation_date: 2015-03-31T22:25:17Z

[Term]
id: CL:2000095
name: cord blood hematopoietic stem cell
namespace: cell
def: "Any hematopoietic stem cell that is part of a umbilical cord blood." [GOC:TermGenie]
is_a: CL:0002246 ! peripheral blood stem cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0012168 ! umbilical cord blood
relationship: part_of UBERON:0012168 ! umbilical cord blood
created_by: TermGenie
creation_date: 2015-05-26T18:58:34Z

[Term]
id: CL:2000096
name: reticular layer of dermis fibroblast
namespace: cell
def: "Any fibroblast that is part of a reticular layer of dermis." [GOC:TermGenie]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002551 ! fibroblast of dermis
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001993 ! reticular layer of dermis
relationship: part_of UBERON:0001993 ! reticular layer of dermis
created_by: TermGenie
creation_date: 2015-08-11T16:28:16Z

[Term]
id: CL:2000097
name: midbrain dopaminergic neuron
namespace: cell
def: "Any dopaminergic neuron that is part of a midbrain." [GOC:TermGenie]
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000700 ! dopaminergic neuron
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain
created_by: TermGenie
creation_date: 2015-12-03T16:42:40Z

[Term]
id: CLO:0000001
name: cell line cell
is_a: CL:0000010 ! cultured cell

[Term]
id: CLO:0000018
name: mortal cell line cell
is_a: CLO:0000001 ! cell line cell

[Term]
id: CLO:0000019
name: immortal cell line cell
is_a: CLO:0000001 ! cell line cell

[Term]
id: CP:0000000
name: neutrophillic cytoplasm
namespace: cell
def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
created_by: tmeehan
creation_date: 2010-05-25T01:36:34Z

[Term]
id: CP:0000025
name: lobed nucleus
namespace: cell
def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." [GOC:tfm]
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: bearer_of PATO:0001979 ! lobed
relationship: bearer_of PATO:0001979 ! lobed
created_by: tmeehan
creation_date: 2009-12-22T03:54:43Z

[Term]
id: CP:0000027
name: acidophilic cytoplasm
namespace: cell
def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm]
synonym: "eosinophilic" NARROW []
is_a: GO:0005737 ! cytoplasm
created_by: tmeehan
creation_date: 2009-12-22T04:23:25Z

[Term]
id: CP:0000028
name: basophilic cytoplasm
namespace: cell
def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: bearer_of PATO:0002094 ! basophilic
relationship: bearer_of PATO:0002094 ! basophilic
created_by: tmeehan
creation_date: 2009-12-22T04:24:54Z

[Term]
id: CP:0000035
name: polychromatophilic cytoplasm
namespace: cell
def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
created_by: tmeehan
creation_date: 2009-12-28T04:25:23Z

[Term]
id: CP:0000037
name: increased nucleus size
namespace: cell
def: "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." [GOC:tfm]
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: bearer_of PATO:0000586 ! increased size
relationship: bearer_of PATO:0000586 ! increased size
created_by: tmeehan
creation_date: 2009-12-23T10:53:24Z

[Term]
id: CP:0000039
name: banded nucleus
namespace: cell
def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." [GOC:tfm]
is_a: GO:0005634 ! nucleus
created_by: tmeehan
creation_date: 2009-12-23T02:18:43Z

[Term]
id: CP:0000040
name: reniform nucleus
namespace: cell
def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." [GOC:tfm]
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: bearer_of PATO:0001871 ! reniform
relationship: bearer_of PATO:0001871 ! reniform
created_by: tmeehan
creation_date: 2009-12-23T02:31:25Z

[Term]
id: CP:0000043
name: cartwheel heterochromatin
namespace: cell
def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm]
is_a: GO:0000792 ! heterochromatin
created_by: tmeehan
creation_date: 2009-12-28T04:28:35Z

[Term]
id: GO:0000018
name: regulation of DNA recombination
is_a: GO:0051052 ! regulation of DNA metabolic process

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0000278
name: mitotic cell cycle
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0000280
name: nuclear division
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000323
name: lytic vacuole
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000785
name: chromatin
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000791
name: euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0001505
name: regulation of neurotransmitter levels
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0001578
name: microtubule bundle formation
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0001649
name: osteoblast differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0001667
name: ameboidal-type cell migration
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001675
name: acrosome assembly
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0001775
name: cell activation
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0001816
name: cytokine production
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0001817
name: regulation of cytokine production
is_a: GO:0051239 ! regulation of multicellular organismal process

[Term]
id: GO:0001818
name: negative regulation of cytokine production
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051241 ! negative regulation of multicellular organismal process

[Term]
id: GO:0001820
name: serotonin secretion
is_a: GO:0006837 ! serotonin transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0001821
name: histamine secretion
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0001894
name: tissue homeostasis
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0001906
name: cell killing
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
is_a: GO:0001906 ! cell killing
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0001974
name: blood vessel remodeling
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0002001
name: renin secretion into blood stream
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0002200
name: somatic diversification of immune receptors
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002215
name: defense response to nematode
is_a: GO:0009624 ! response to nematode
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002227
name: innate immune response in mucosa
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002228
name: natural killer cell mediated immunity
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002249
name: lymphocyte anergy
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002250
name: adaptive immune response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002251
name: organ or tissue specific immune response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002263
name: cell activation involved in immune response
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002274
name: myeloid leukocyte activation
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0002286
name: T cell activation involved in immune response
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0002287
name: alpha-beta T cell activation involved in immune response
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0002288
name: NK T cell activation involved in immune response
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0051132 ! NK T cell activation

[Term]
id: GO:0002312
name: B cell activation involved in immune response
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0002313
name: mature B cell differentiation involved in immune response
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0002314
name: germinal center B cell differentiation
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002335
name: mature B cell differentiation
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002339
name: B cell selection
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002343
name: peripheral B cell selection
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002344
name: B cell affinity maturation
is_a: GO:0002343 ! peripheral B cell selection

[Term]
id: GO:0002349
name: histamine production involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002367
name: cytokine production involved in immune response
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002369
name: T cell cytokine production
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002376
name: immune system process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0002385
name: mucosal immune response
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002386
name: immune response in mucosal-associated lymphoid tissue
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002432
name: granuloma formation
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002443
name: leukocyte mediated immunity
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002456
name: T cell mediated immunity
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002507
name: tolerance induction
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002514
name: B cell tolerance induction
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002515
name: B cell anergy
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002521
name: leukocyte differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0002536
name: respiratory burst involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
is_a: GO:0002679 ! respiratory burst involved in defense response

[Term]
id: GO:0002537
name: nitric oxide production involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002538
name: arachidonic acid metabolite production involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002539
name: prostaglandin production involved in inflammatory response
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002540
name: leukotriene production involved in inflammatory response
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002544
name: chronic inflammatory response
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002548
name: monocyte chemotaxis
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002574
name: thrombocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002634
name: regulation of germinal center formation
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis

[Term]
id: GO:0002637
name: regulation of immunoglobulin production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response

[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response

[Term]
id: GO:0002643
name: regulation of tolerance induction
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:2000026 ! regulation of multicellular organismal development

[Term]
id: GO:0002645
name: positive regulation of tolerance induction
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process

[Term]
id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002658
name: regulation of peripheral tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response

[Term]
id: GO:0002660
name: positive regulation of peripheral tolerance induction
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction

[Term]
id: GO:0002679
name: respiratory burst involved in defense response
is_a: GO:0002252 ! immune effector process
is_a: GO:0045730 ! respiratory burst

[Term]
id: GO:0002682
name: regulation of immune system process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0002683
name: negative regulation of immune system process
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process

[Term]
id: GO:0002684
name: positive regulation of immune system process
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis

[Term]
id: GO:0002694
name: regulation of leukocyte activation
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation

[Term]
id: GO:0002697
name: regulation of immune effector process
is_a: GO:0002682 ! regulation of immune system process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
is_a: GO:0002697 ! regulation of immune effector process

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
is_a: GO:0002697 ! regulation of immune effector process

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
is_a: GO:0002703 ! regulation of leukocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity

[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002775
name: antimicrobial peptide production
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002776
name: antimicrobial peptide secretion
is_a: GO:0002790 ! peptide secretion

[Term]
id: GO:0002790
name: peptide secretion
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0002819
name: regulation of adaptive immune response
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002819 ! regulation of adaptive immune response

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002825
name: regulation of T-helper 1 type immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002827
name: positive regulation of T-helper 1 type immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response

[Term]
id: GO:0002828
name: regulation of type 2 immune response
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002830
name: positive regulation of type 2 immune response
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
is_a: GO:0002712 ! regulation of B cell mediated immunity

[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response

[Term]
id: GO:0002902
name: regulation of B cell apoptotic process
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process

[Term]
id: GO:0002905
name: regulation of mature B cell apoptotic process
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0032844 ! regulation of homeostatic process

[Term]
id: GO:0003006
name: developmental process involved in reproduction
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0003008
name: system process
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003013
name: circulatory system process
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003674
name: molecular_function

[Term]
id: GO:0004871
name: signal transducer activity
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0004872
name: receptor activity
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0004888
name: transmembrane signaling receptor activity
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0005044
name: scavenger receptor activity
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0005215
name: transporter activity
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005488
name: binding
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005575
name: cellular_component

[Term]
id: GO:0005623
name: cell
is_a: CARO:0000003 ! anatomical structure
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005634
name: nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005730
name: nucleolus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005737
name: cytoplasm
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005764
name: lysosome
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005766
name: primary lysosome
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005773
name: vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005794
name: Golgi apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005840
name: ribosome
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005902
name: microvillus
is_a: GO:0098858 ! actin-based cell projection

[Term]
id: GO:0005911
name: cell-cell junction
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0005929
name: cilium
is_a: GO:0042995 ! cell projection
is_a: GO:0043226 ! organelle

[Term]
id: GO:0006022
name: aminoglycan metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0006139
name: nucleobase-containing compound metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0006259
name: DNA metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0006310
name: DNA recombination
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006323
name: DNA packaging
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0006629
name: lipid metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0006694
name: steroid biosynthetic process
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0006699
name: bile acid biosynthetic process
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0006725
name: cellular aromatic compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006790
name: sulfur compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006801
name: superoxide metabolic process
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0006807
name: nitrogen compound metabolic process
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006810
name: transport
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0006811
name: ion transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006812
name: cation transport
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006820
name: anion transport
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006835
name: dicarboxylic acid transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006836
name: neurotransmitter transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006837
name: serotonin transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0006865
name: amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0006869
name: lipid transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0006897
name: endocytosis
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006909
name: phagocytosis
is_a: GO:0006897 ! endocytosis
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006928
name: movement of cell or subcellular component
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006935
name: chemotaxis
is_a: GO:0042330 ! taxis

[Term]
id: GO:0006937
name: regulation of muscle contraction
is_a: GO:0090257 ! regulation of muscle system process

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
is_a: GO:0006937 ! regulation of muscle contraction

[Term]
id: GO:0006950
name: response to stress
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006954
name: inflammatory response
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006955
name: immune response
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006996
name: organelle organization
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0006997
name: nucleus organization
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007010
name: cytoskeleton organization
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007017
name: microtubule-based process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007049
name: cell cycle
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007067
name: mitotic nuclear division
is_a: GO:0000280 ! nuclear division
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0007113
name: endomitotic cell cycle
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007126
name: meiotic nuclear division
is_a: GO:0000280 ! nuclear division
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0007135
name: meiosis II
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007140
name: male meiosis
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007142
name: male meiosis II
is_a: GO:0007135 ! meiosis II

[Term]
id: GO:0007143
name: female meiotic division
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007147
name: female meiosis II
is_a: GO:0007135 ! meiosis II

[Term]
id: GO:0007155
name: cell adhesion
is_a: GO:0022610 ! biological adhesion

[Term]
id: GO:0007159
name: leukocyte cell-cell adhesion
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process

[Term]
id: GO:0007269
name: neurotransmitter secretion
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0007276
name: gamete generation
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0007281
name: germ cell development
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development

[Term]
id: GO:0007283
name: spermatogenesis
is_a: GO:0048232 ! male gamete generation

[Term]
id: GO:0007288
name: sperm axoneme assembly
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0035082 ! axoneme assembly

[Term]
id: GO:0007289
name: spermatid nucleus differentiation
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0007292
name: female gamete generation
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007585
name: respiratory gaseous exchange
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0007589
name: body fluid secretion
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007596
name: blood coagulation
is_a: GO:0007599 ! hemostasis
is_a: GO:0050817 ! coagulation

[Term]
id: GO:0007599
name: hemostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0008015
name: blood circulation
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008104
name: protein localization
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0008150
name: biological_process

[Term]
id: GO:0008152
name: metabolic process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0008202
name: steroid metabolic process
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0008206
name: bile acid metabolic process
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0008283
name: cell proliferation
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0008284
name: positive regulation of cell proliferation
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048522 ! positive regulation of cellular process

[Term]
id: GO:0008285
name: negative regulation of cell proliferation
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048523 ! negative regulation of cellular process

[Term]
id: GO:0008289
name: lipid binding
is_a: GO:0005488 ! binding

[Term]
id: GO:0008509
name: anion transmembrane transporter activity
is_a: GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0008514
name: organic anion transmembrane transporter activity
is_a: GO:0008509 ! anion transmembrane transporter activity

[Term]
id: GO:0008610
name: lipid biosynthetic process
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0009058
name: biosynthetic process
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0009266
name: response to temperature stimulus
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009306
name: protein secretion
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0009314
name: response to radiation
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009399
name: nitrogen fixation
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0009411
name: response to UV
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009416
name: response to light stimulus
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0009566
name: fertilization
is_a: GO:0044702 ! single organism reproductive process

[Term]
id: GO:0009581
name: detection of external stimulus
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009589
name: detection of UV
is_a: GO:0009411 ! response to UV
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009590
name: detection of gravity
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009593
name: detection of chemical stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009605
name: response to external stimulus
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009612
name: response to mechanical stimulus
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009617
name: response to bacterium
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009624
name: response to nematode
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009628
name: response to abiotic stimulus
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009629
name: response to gravity
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0009887
name: organ morphogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048518 ! positive regulation of biological process

[Term]
id: GO:0009914
name: hormone transport
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0009987
name: cellular process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process

[Term]
id: GO:0010817
name: regulation of hormone levels
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0010941
name: regulation of cell death
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0012506
name: vesicle membrane
is_a: GO:0031090 ! organelle membrane

[Term]
id: GO:0014046
name: dopamine secretion
is_a: GO:0015872 ! dopamine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0014047
name: glutamate secretion
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0014051
name: gamma-aminobutyric acid secretion
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0014055
name: acetylcholine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061526 ! acetylcholine secretion

[Term]
id: GO:0014704
name: intercalated disc
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0015031
name: protein transport
is_a: GO:0008104 ! protein localization
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015075
name: ion transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015103
name: inorganic anion transmembrane transporter activity
is_a: GO:0008509 ! anion transmembrane transporter activity

[Term]
id: GO:0015106
name: bicarbonate transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015669
name: gas transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0015671
name: oxygen transport
is_a: GO:0015669 ! gas transport

[Term]
id: GO:0015672
name: monovalent inorganic cation transport
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015695
name: organic cation transport
is_a: GO:0006812 ! cation transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015696
name: ammonium transport
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015711
name: organic anion transport
is_a: GO:0006820 ! anion transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015718
name: monocarboxylic acid transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015721
name: bile acid and bile salt transport
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015740
name: C4-dicarboxylate transport
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015800
name: acidic amino acid transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015804
name: neutral amino acid transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015807
name: L-amino acid transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015810
name: aspartate transport
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0015800 ! acidic amino acid transport

[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015816
name: glycine transport
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015833
name: peptide transport
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015844
name: monoamine transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015849
name: organic acid transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015850
name: organic hydroxy compound transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015870
name: acetylcholine transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:1901374 ! acetate ester transport

[Term]
id: GO:0015872
name: dopamine transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015874
name: norepinephrine transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0016020
name: membrane
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0016023
name: cytoplasmic, membrane-bounded vesicle
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0031988 ! membrane-bounded vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0016043
name: cellular component organization
is_a: GO:0009987 ! cellular process
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0016048
name: detection of temperature stimulus
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0016050
name: vesicle organization
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0016053
name: organic acid biosynthetic process
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0016192
name: vesicle-mediated transport
is_a: GO:0006810 ! transport

[Term]
id: GO:0016337
name: single organismal cell-cell adhesion
is_a: GO:0098602 ! single organism cell adhesion
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0016444
name: somatic cell DNA recombination
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0016445
name: somatic diversification of immunoglobulins
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0016446
name: somatic hypermutation of immunoglobulin genes
is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016447
name: somatic recombination of immunoglobulin gene segments
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016477
name: cell migration
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0017145
name: stem cell division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0018130
name: heterocycle biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase-containing compound metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process

[Term]
id: GO:0019222
name: regulation of metabolic process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0019226
name: transmission of nerve impulse
is_a: GO:0035637 ! multicellular organismal signaling
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0019438
name: aromatic compound biosynthetic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0019724
name: B cell mediated immunity
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019814
name: immunoglobulin complex
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0019815
name: B cell receptor complex
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0098802 ! plasma membrane receptor complex

[Term]
id: GO:0019882
name: antigen processing and presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019884
name: antigen processing and presentation of exogenous antigen
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0021700
name: developmental maturation
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0022402
name: cell cycle process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
is_a: GO:0030155 ! regulation of cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion

[Term]
id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0022414
name: reproductive process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0022602
name: ovulation cycle process
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0022607
name: cellular component assembly
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0022610
name: biological adhesion
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0022857
name: transmembrane transporter activity
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0022891
name: substrate-specific transmembrane transporter activity
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0022892
name: substrate-specific transporter activity
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0023052
name: signaling
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0023061
name: signal release
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0030017
name: sarcomere
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0030030
name: cell projection organization
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030031
name: cell projection assembly
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0030054
name: cell junction
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0030072
name: peptide hormone secretion
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0030073
name: insulin secretion
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030098
name: lymphocyte differentiation
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030099
name: myeloid cell differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0030103
name: vasopressin secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030141
name: secretory granule
is_a: GO:0099503 ! secretory vesicle

[Term]
id: GO:0030154
name: cell differentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0030155
name: regulation of cell adhesion
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0030182
name: neuron differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0030183
name: B cell differentiation
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0030186
name: melatonin metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0030187
name: melatonin biosynthetic process
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0030202
name: heparin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0030210
name: heparin biosynthetic process
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0030217
name: T cell differentiation
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0030218
name: erythrocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0030219
name: megakaryocyte differentiation
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0030221
name: basophil differentiation
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030222
name: eosinophil differentiation
is_a: GO:0030851 ! granulocyte differentiation
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030223
name: neutrophil differentiation
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030224
name: monocyte differentiation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030225
name: macrophage differentiation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030252
name: growth hormone secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030261
name: chromosome condensation
is_a: GO:0006323 ! DNA packaging
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
is_a: GO:0030261 ! chromosome condensation

[Term]
id: GO:0030316
name: osteoclast differentiation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030317
name: sperm motility
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0030334
name: regulation of cell migration
is_a: GO:2000145 ! regulation of cell motility

[Term]
id: GO:0030335
name: positive regulation of cell migration
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000147 ! positive regulation of cell motility

[Term]
id: GO:0030529
name: intracellular ribonucleoprotein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0030595
name: leukocyte chemotaxis
is_a: GO:0050900 ! leukocyte migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part

[Term]
id: GO:0030667
name: secretory granule membrane
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane

[Term]
id: GO:0030851
name: granulocyte differentiation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030855
name: epithelial cell differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0031090
name: organelle membrane
is_a: GO:0016020 ! membrane
is_a: GO:0044422 ! organelle part

[Term]
id: GO:0031268
name: pseudopodium organization
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0031294
name: lymphocyte costimulation
is_a: GO:0002376 ! immune system process
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0031323
name: regulation of cellular metabolic process
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0031325
name: positive regulation of cellular metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048522 ! positive regulation of cellular process

[Term]
id: GO:0031347
name: regulation of defense response
is_a: GO:0080134 ! regulation of response to stress

[Term]
id: GO:0031348
name: negative regulation of defense response
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus

[Term]
id: GO:0031349
name: positive regulation of defense response
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus

[Term]
id: GO:0031410
name: cytoplasmic vesicle
is_a: GO:0031982 ! vesicle
is_a: GO:0043229 ! intracellular organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031982
name: vesicle
is_a: GO:0043226 ! organelle

[Term]
id: GO:0031988
name: membrane-bounded vesicle
is_a: GO:0031982 ! vesicle
is_a: GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0032101
name: regulation of response to external stimulus
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus

[Term]
id: GO:0032274
name: gonadotropin secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032275
name: luteinizing hormone secretion
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032394
name: MHC class Ib receptor activity
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0032501
name: multicellular organismal process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032502
name: developmental process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032606
name: type I interferon production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032609
name: interferon-gamma production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032611
name: interleukin-1 beta production
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032649
name: regulation of interferon-gamma production
is_a: GO:0001817 ! regulation of cytokine production

[Term]
id: GO:0032689
name: negative regulation of interferon-gamma production
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production

[Term]
id: GO:0032782
name: bile acid secretion
is_a: GO:0015721 ! bile acid and bile salt transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0032814
name: regulation of natural killer cell activation
is_a: GO:0051249 ! regulation of lymphocyte activation

[Term]
id: GO:0032816
name: positive regulation of natural killer cell activation
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0032844
name: regulation of homeostatic process
is_a: GO:0050789 ! regulation of biological process
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0032879
name: regulation of localization
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0032880
name: regulation of protein localization
is_a: GO:0032879 ! regulation of localization

[Term]
id: GO:0032940
name: secretion by cell
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046903 ! secretion
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0032941
name: secretion by tissue
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032943
name: mononuclear cell proliferation
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation

[Term]
id: GO:0032991
name: macromolecular complex
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0032997
name: Fc receptor complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0033001
name: Fc-gamma receptor III complex
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033036
name: macromolecule localization
is_a: GO:0051179 ! localization

[Term]
id: GO:0033151
name: V(D)J recombination
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus

[Term]
id: GO:0033152
name: immunoglobulin V(D)J recombination
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033326
name: cerebrospinal fluid secretion
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0033363
name: secretory granule organization
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0033365
name: protein localization to organelle
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0033366
name: protein localization to secretory granule
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0033374
name: protein localization to T cell secretory granule
is_a: GO:0033366 ! protein localization to secretory granule

[Term]
id: GO:0033375
name: protease localization to T cell secretory granule
is_a: GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033380
name: granzyme B localization to T cell secretory granule
is_a: GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0034102
name: erythrocyte clearance
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0034109
name: homotypic cell-cell adhesion
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0034110
name: regulation of homotypic cell-cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion

[Term]
id: GO:0034111
name: negative regulation of homotypic cell-cell adhesion
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion

[Term]
id: GO:0034112
name: positive regulation of homotypic cell-cell adhesion
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion

[Term]
id: GO:0034613
name: cellular protein localization
is_a: GO:0008104 ! protein localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0034641
name: cellular nitrogen compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0034754
name: cellular hormone metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0035010
name: encapsulation of foreign target
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0035051
name: cardiocyte differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0035082
name: axoneme assembly
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0035369
name: pre-B cell receptor complex
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0035637
name: multicellular organismal signaling
is_a: GO:0044700 ! single organism signaling
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0035929
name: steroid hormone secretion
is_a: GO:0006869 ! lipid transport
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0035930
name: corticosteroid hormone secretion
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035931
name: mineralocorticoid secretion
is_a: GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:0035933
name: glucocorticoid secretion
is_a: GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:0035935
name: androgen secretion
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035936
name: testosterone secretion
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035935 ! androgen secretion

[Term]
id: GO:0035937
name: estrogen secretion
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035938
name: estradiol secretion
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035937 ! estrogen secretion

[Term]
id: GO:0036160
name: melanocyte-stimulating hormone secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036161
name: calcitonin secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036321
name: ghrelin secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0038023
name: signaling receptor activity
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0038024
name: cargo receptor activity
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0040011
name: locomotion
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040012
name: regulation of locomotion
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0040017
name: positive regulation of locomotion
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process

[Term]
id: GO:0042101
name: T cell receptor complex
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: has_part PR:000001020 {comment="To be added to GO"} ! CD3 epsilon

[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042110
name: T cell activation
is_a: GO:0046649 ! lymphocyte activation
is_a: GO:0070489 ! T cell aggregation

[Term]
id: GO:0042113
name: B cell activation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042127
name: regulation of cell proliferation
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0042129
name: regulation of T cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation

[Term]
id: GO:0042267
name: natural killer cell mediated cytotoxicity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0042330
name: taxis
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0042430
name: indole-containing compound metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042445
name: hormone metabolic process
is_a: GO:0008152 ! metabolic process
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0042446
name: hormone biosynthetic process
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042470
name: melanosome
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0042475
name: odontogenesis of dentin-containing tooth
is_a: GO:0042476 ! odontogenesis

[Term]
id: GO:0042476
name: odontogenesis
is_a: GO:0009887 ! organ morphogenesis

[Term]
id: GO:0042481
name: regulation of odontogenesis
is_a: GO:2000027 ! regulation of organ morphogenesis

[Term]
id: GO:0042483
name: negative regulation of odontogenesis
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process

[Term]
id: GO:0042492
name: gamma-delta T cell differentiation
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0042554
name: superoxide anion generation
is_a: GO:0006801 ! superoxide metabolic process

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0042582
name: azurophil granule
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
is_a: GO:0030667 ! secretory granule membrane

[Term]
id: GO:0042590
name: antigen processing and presentation of exogenous peptide antigen via MHC class I
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0042592
name: homeostatic process
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0042611
name: MHC protein complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042692
name: muscle cell differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0042701
name: progesterone secretion
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0042742
name: defense response to bacterium
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0042886
name: amide transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042981
name: regulation of apoptotic process
is_a: GO:0043067 ! regulation of programmed cell death

[Term]
id: GO:0042995
name: cell projection
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043011
name: myeloid dendritic cell differentiation
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0043067
name: regulation of programmed cell death
is_a: GO:0010941 ! regulation of cell death

[Term]
id: GO:0043129
name: surfactant homeostasis
is_a: GO:0048875 ! chemical homeostasis within a tissue

[Term]
id: GO:0043134
name: regulation of hindgut contraction
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044058 ! regulation of digestive system process

[Term]
id: GO:0043170
name: macromolecule metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0043207
name: response to external biotic stimulus
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043208
name: glycosphingolipid binding
is_a: GO:0046625 ! sphingolipid binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0043226
name: organelle
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043227
name: membrane-bounded organelle
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043228
name: non-membrane-bounded organelle
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
is_a: GO:0043226 ! organelle
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular non-membrane-bounded organelle
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043234
name: protein complex
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0043235
name: receptor complex
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043277
name: apoptotic cell clearance
is_a: GO:0006909 ! phagocytosis

[Term]
id: GO:0043368
name: positive T cell selection
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043370
name: regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation

[Term]
id: GO:0043372
name: positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation

[Term]
id: GO:0043384
name: pre-T cell receptor complex
is_a: GO:0098802 ! plasma membrane receptor complex

[Term]
id: GO:0043436
name: oxoacid metabolic process
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0043603
name: cellular amide metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0043604
name: amide biosynthetic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0044057
name: regulation of system process
is_a: GO:0051239 ! regulation of multicellular organismal process

[Term]
id: GO:0044058
name: regulation of digestive system process
is_a: GO:0044057 ! regulation of system process

[Term]
id: GO:0044237
name: cellular metabolic process
is_a: GO:0008152 ! metabolic process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0044238
name: primary metabolic process
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044249
name: cellular biosynthetic process
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044260
name: cellular macromolecule metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044271
name: cellular nitrogen compound biosynthetic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044272
name: sulfur compound biosynthetic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044281
name: small molecule metabolic process
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0044283
name: small molecule biosynthetic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0044291
name: cell-cell contact zone
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0044421
name: extracellular region part
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0044422
name: organelle part
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0044424
name: intracellular part
is_a: GO:0044464 ! cell part

[Term]
id: GO:0044425
name: membrane part
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0044427
name: chromosomal part
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0044428
name: nuclear part
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0044433
name: cytoplasmic vesicle part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0044444
name: cytoplasmic part
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0044446
name: intracellular organelle part
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0044449
name: contractile fiber part
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044459
name: plasma membrane part
is_a: GO:0044425 ! membrane part
is_a: GO:0044464 ! cell part

[Term]
id: GO:0044464
name: cell part
is_a: CARO:0000014 ! cell part
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0044699
name: single-organism process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044700
name: single organism signaling
is_a: GO:0023052 ! signaling
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0044702
name: single organism reproductive process
is_a: GO:0022414 ! reproductive process
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0044707
name: single-multicellular organism process
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0044710
name: single-organism metabolic process
is_a: GO:0008152 ! metabolic process
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0044711
name: single-organism biosynthetic process
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0044763
name: single-organism cellular process
is_a: GO:0009987 ! cellular process
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0044765
name: single-organism transport
is_a: GO:0006810 ! transport
is_a: GO:1902578 ! single-organism localization

[Term]
id: GO:0044767
name: single-organism developmental process
is_a: GO:0032502 ! developmental process
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0045058
name: T cell selection
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0045087
name: innate immune response
is_a: GO:0006952 ! defense response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0045117
name: azole transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0045184
name: establishment of protein localization
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0045190
name: isotype switching
is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0045191
name: regulation of isotype switching
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:2000026 ! regulation of multicellular organismal development

[Term]
id: GO:0045321
name: leukocyte activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0045443
name: juvenile hormone secretion
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0045444
name: fat cell differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0045453
name: bone resorption
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0045457
name: ecdysteroid secretion
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0045580
name: regulation of T cell differentiation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation

[Term]
id: GO:0045595
name: regulation of cell differentiation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1902105 ! regulation of leukocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation

[Term]
id: GO:0045622
name: regulation of T-helper cell differentiation
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0045624
name: positive regulation of T-helper cell differentiation
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0045625
name: regulation of T-helper 1 cell differentiation
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation

[Term]
id: GO:0045627
name: positive regulation of T-helper 1 cell differentiation
is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation

[Term]
id: GO:0045628
name: regulation of T-helper 2 cell differentiation
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation

[Term]
id: GO:0045630
name: positive regulation of T-helper 2 cell differentiation
is_a: GO:0002830 ! positive regulation of type 2 immune response
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation

[Term]
id: GO:0045730
name: respiratory burst
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process

[Term]
id: GO:0045830
name: positive regulation of isotype switching
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0050871 ! positive regulation of B cell activation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process

[Term]
id: GO:0045911
name: positive regulation of DNA recombination
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051054 ! positive regulation of DNA metabolic process

[Term]
id: GO:0045935
name: positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046483
name: heterocycle metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0046625
name: sphingolipid binding
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0046629
name: gamma-delta T cell activation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046631
name: alpha-beta T cell activation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046634
name: regulation of alpha-beta T cell activation
is_a: GO:0050863 ! regulation of T cell activation

[Term]
id: GO:0046635
name: positive regulation of alpha-beta T cell activation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation

[Term]
id: GO:0046637
name: regulation of alpha-beta T cell differentiation
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation

[Term]
id: GO:0046638
name: positive regulation of alpha-beta T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation

[Term]
id: GO:0046649
name: lymphocyte activation
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0046651
name: lymphocyte proliferation
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0046717
name: acid secretion
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046864
name: isoprenoid transport
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046865
name: terpenoid transport
is_a: GO:0046864 ! isoprenoid transport

[Term]
id: GO:0046879
name: hormone secretion
is_a: GO:0009914 ! hormone transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0046903
name: secretion
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0046942
name: carboxylic acid transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0048002
name: antigen processing and presentation of peptide antigen
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0048103
name: somatic stem cell division
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0048137
name: spermatocyte division
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051301 ! cell division

[Term]
id: GO:0048232
name: male gamete generation
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0048240
name: sperm capacitation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation

[Term]
id: GO:0048241
name: epinephrine transport
is_a: GO:0009914 ! hormone transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0048242
name: epinephrine secretion
is_a: GO:0046879 ! hormone secretion
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048243
name: norepinephrine secretion
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048285
name: organelle fission
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048293
name: regulation of isotype switching to IgE isotypes
is_a: GO:0045191 ! regulation of isotype switching

[Term]
id: GO:0048295
name: positive regulation of isotype switching to IgE isotypes
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes

[Term]
id: GO:0048468
name: cell development
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0048469
name: cell maturation
is_a: GO:0021700 ! developmental maturation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0048477
name: oogenesis
is_a: GO:0007281 ! germ cell development
is_a: GO:0007292 ! female gamete generation

[Term]
id: GO:0048511
name: rhythmic process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0048518
name: positive regulation of biological process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0048519
name: negative regulation of biological process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0048520
name: positive regulation of behavior
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0048583
name: regulation of response to stimulus
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048770
name: pigment granule
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0048771
name: tissue remodeling
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0048856
name: anatomical structure development
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048869
name: cellular developmental process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0048870
name: cell motility
is_a: GO:0006928 ! movement of cell or subcellular component
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0048875
name: chemical homeostasis within a tissue
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0048878
name: chemical homeostasis
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0050432
name: catecholamine secretion
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
is_a: GO:0042127 ! regulation of cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation

[Term]
id: GO:0050708
name: regulation of protein secretion
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903530 ! regulation of secretion by cell

[Term]
id: GO:0050714
name: positive regulation of protein secretion
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903532 ! positive regulation of secretion by cell

[Term]
id: GO:0050727
name: regulation of inflammatory response
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:1903034 ! regulation of response to wounding

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:1903035 ! negative regulation of response to wounding

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:1903036 ! positive regulation of response to wounding

[Term]
id: GO:0050776
name: regulation of immune response
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0050777
name: negative regulation of immune response
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0050789
name: regulation of biological process
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0050793
name: regulation of developmental process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0050794
name: regulation of cellular process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0050795
name: regulation of behavior
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0050817
name: coagulation
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0050863
name: regulation of T cell activation
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion

[Term]
id: GO:0050864
name: regulation of B cell activation
is_a: GO:0051249 ! regulation of lymphocyte activation

[Term]
id: GO:0050865
name: regulation of cell activation
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0050866
name: negative regulation of cell activation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion

[Term]
id: GO:0050870
name: positive regulation of T cell activation
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion

[Term]
id: GO:0050871
name: positive regulation of B cell activation
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0050877
name: neurological system process
is_a: GO:0003008 ! system process

[Term]
id: GO:0050878
name: regulation of body fluid levels
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050896
name: response to stimulus
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0050900
name: leukocyte migration
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
is_a: GO:0009584 ! detection of visible light
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception

[Term]
id: GO:0050910
name: detection of mechanical stimulus involved in sensory perception of sound
is_a: GO:0050877 ! neurological system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception

[Term]
id: GO:0050911
name: detection of chemical stimulus involved in sensory perception of smell
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception

[Term]
id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception

[Term]
id: GO:0050920
name: regulation of chemotaxis
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050795 ! regulation of behavior

[Term]
id: GO:0050921
name: positive regulation of chemotaxis
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0050920 ! regulation of chemotaxis

[Term]
id: GO:0050960
name: detection of temperature stimulus involved in thermoception
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception

[Term]
id: GO:0050961
name: detection of temperature stimulus involved in sensory perception
is_a: GO:0016048 ! detection of temperature stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: GO:0050974
name: detection of mechanical stimulus involved in sensory perception
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050982 ! detection of mechanical stimulus

[Term]
id: GO:0050976
name: detection of mechanical stimulus involved in sensory perception of touch
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception

[Term]
id: GO:0050982
name: detection of mechanical stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0051023
name: regulation of immunoglobulin secretion
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0050708 ! regulation of protein secretion

[Term]
id: GO:0051024
name: positive regulation of immunoglobulin secretion
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0051023 ! regulation of immunoglobulin secretion

[Term]
id: GO:0051046
name: regulation of secretion
is_a: GO:0051049 ! regulation of transport

[Term]
id: GO:0051047
name: positive regulation of secretion
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport

[Term]
id: GO:0051049
name: regulation of transport
is_a: GO:0032879 ! regulation of localization

[Term]
id: GO:0051050
name: positive regulation of transport
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process

[Term]
id: GO:0051093
name: negative regulation of developmental process
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0051132
name: NK T cell activation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0051146
name: striated muscle cell differentiation
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051171
name: regulation of nitrogen compound metabolic process
is_a: GO:0019222 ! regulation of metabolic process

[Term]
id: GO:0051173
name: positive regulation of nitrogen compound metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process

[Term]
id: GO:0051179
name: localization
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051222
name: positive regulation of protein transport
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization

[Term]
id: GO:0051234
name: establishment of localization
is_a: GO:0051179 ! localization

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
is_a: GO:0002694 ! regulation of leukocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation

[Term]
id: GO:0051270
name: regulation of cellular component movement
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0051272
name: positive regulation of cellular component movement
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051270 ! regulation of cellular component movement

[Term]
id: GO:0051276
name: chromosome organization
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0051301
name: cell division
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0051458
name: corticotropin secretion
is_a: GO:0030072 ! peptide hormone secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0051606
name: detection of stimulus
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051608
name: histamine transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0051641
name: cellular localization
is_a: GO:0051179 ! localization

[Term]
id: GO:0051649
name: establishment of localization in cell
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0051704
name: multi-organism process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051707
name: response to other organism
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051767
name: nitric-oxide synthase biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051861
name: glycolipid binding
is_a: GO:0008289 ! lipid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0051937
name: catecholamine transport
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0060047
name: heart contraction
is_a: GO:0003015 ! heart process

[Term]
id: GO:0060054
name: positive regulation of epithelial cell proliferation involved in wound healing
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation

[Term]
id: GO:0060089
name: molecular transducer activity
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0060249
name: anatomical structure homeostasis
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
is_a: GO:0019222 ! regulation of metabolic process

[Term]
id: GO:0060326
name: cell chemotaxis
is_a: GO:0006935 ! chemotaxis
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0060341
name: regulation of cellular localization
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0060374
name: mast cell differentiation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0060591
name: chondroblast differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060986
name: endocrine hormone secretion
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0061526
name: acetylcholine secretion
is_a: GO:0015870 ! acetylcholine transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0061527
name: dopamine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014046 ! dopamine secretion

[Term]
id: GO:0061528
name: aspartate secretion
is_a: GO:0015810 ! aspartate transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0061529
name: epinephrine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0048242 ! epinephrine secretion

[Term]
id: GO:0061530
name: aspartate secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061528 ! aspartate secretion

[Term]
id: GO:0061533
name: norepinephrine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0061534
name: gamma-aminobutyric acid secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0061535
name: glutamate secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014047 ! glutamate secretion

[Term]
id: GO:0061536
name: glycine secretion
is_a: GO:0015816 ! glycine transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0061537
name: glycine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061536 ! glycine secretion

[Term]
id: GO:0061538
name: histamine secretion, neurotransmission
is_a: GO:0001821 ! histamine secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0061539
name: octopamine secretion
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0061540
name: octopamine secretion, neurotransmission
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061539 ! octopamine secretion

[Term]
id: GO:0061544
name: peptide secretion, neurotransmission
is_a: GO:0002790 ! peptide secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0061584
name: hypocretin secretion
is_a: GO:0002790 ! peptide secretion

[Term]
id: GO:0061585
name: hypocretin secretion, neurotransmission
is_a: GO:0061544 ! peptide secretion, neurotransmission
is_a: GO:0061584 ! hypocretin secretion

[Term]
id: GO:0065007
name: biological regulation
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0065008
name: regulation of biological quality
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0070091
name: glucagon secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
is_a: GO:0032880 ! regulation of protein localization

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process

[Term]
id: GO:0070253
name: somatostatin secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070254
name: mucus secretion
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0070278
name: extracellular matrix constituent secretion
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0070459
name: prolactin secretion
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070460
name: thyroid-stimulating hormone secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070486
name: leukocyte aggregation
is_a: GO:0007159 ! leukocyte cell-cell adhesion
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0070489
name: T cell aggregation
is_a: GO:0045321 ! leukocyte activation
is_a: GO:0071593 ! lymphocyte aggregation

[Term]
id: GO:0070661
name: leukocyte proliferation
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
is_a: GO:0042127 ! regulation of cell proliferation

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation

[Term]
id: GO:0070727
name: cellular macromolecule localization
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0070820
name: tertiary granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0070925
name: organelle assembly
is_a: GO:0006996 ! organelle organization
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070999
name: detection of mechanical stimulus involved in sensory perception of gravity
is_a: GO:0009590 ! detection of gravity
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception

[Term]
id: GO:0071103
name: DNA conformation change
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0071593
name: lymphocyte aggregation
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0071622
name: regulation of granulocyte chemotaxis
is_a: GO:0002688 ! regulation of leukocyte chemotaxis

[Term]
id: GO:0071624
name: positive regulation of granulocyte chemotaxis
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis

[Term]
id: GO:0071702
name: organic substance transport
is_a: GO:0006810 ! transport

[Term]
id: GO:0071704
name: organic substance metabolic process
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0071705
name: nitrogen compound transport
is_a: GO:0006810 ! transport

[Term]
id: GO:0071706
name: tumor necrosis factor superfamily cytokine production
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071707
name: immunoglobulin heavy chain V-D-J recombination
is_a: GO:0033152 ! immunoglobulin V(D)J recombination

[Term]
id: GO:0071708
name: immunoglobulin light chain V-J recombination
is_a: GO:0033152 ! immunoglobulin V(D)J recombination

[Term]
id: GO:0071735
name: IgG immunoglobulin complex
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071736
name: IgG immunoglobulin complex, circulating
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071735 ! IgG immunoglobulin complex

[Term]
id: GO:0071738
name: IgD immunoglobulin complex
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071739
name: IgD immunoglobulin complex, circulating
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071738 ! IgD immunoglobulin complex

[Term]
id: GO:0071742
name: IgE immunoglobulin complex
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071743
name: IgE immunoglobulin complex, circulating
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071742 ! IgE immunoglobulin complex

[Term]
id: GO:0071745
name: IgA immunoglobulin complex
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071746
name: IgA immunoglobulin complex, circulating
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071745 ! IgA immunoglobulin complex

[Term]
id: GO:0071753
name: IgM immunoglobulin complex
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071754
name: IgM immunoglobulin complex, circulating
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071753 ! IgM immunoglobulin complex

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0071912
name: asynchronous neurotransmitter secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0071941
name: nitrogen cycle metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0071971
name: extracellular exosome assembly
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0072330
name: monocarboxylic acid biosynthetic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0072593
name: reactive oxygen species metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0080090
name: regulation of primary metabolic process
is_a: GO:0019222 ! regulation of metabolic process

[Term]
id: GO:0080134
name: regulation of response to stress
is_a: GO:0048583 ! regulation of response to stimulus

[Term]
id: GO:0090022
name: regulation of neutrophil chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:1902622 ! regulation of neutrophil migration

[Term]
id: GO:0090023
name: positive regulation of neutrophil chemotaxis
is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
is_a: GO:1902624 ! positive regulation of neutrophil migration

[Term]
id: GO:0090257
name: regulation of muscle system process
is_a: GO:0044057 ! regulation of system process

[Term]
id: GO:0090304
name: nucleic acid metabolic process
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0097028
name: dendritic cell differentiation
is_a: GO:0002521 ! leukocyte differentiation

[Term]
id: GO:0097186
name: amelogenesis
is_a: GO:0042475 ! odontogenesis of dentin-containing tooth
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0097367
name: carbohydrate derivative binding
is_a: GO:0005488 ! binding

[Term]
id: GO:0097529
name: myeloid leukocyte migration
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0098542
name: defense response to other organism
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0098588
name: bounding membrane of organelle
is_a: GO:0031090 ! organelle membrane

[Term]
id: GO:0098602
name: single organism cell adhesion
is_a: GO:0007155 ! cell adhesion
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0098609
name: cell-cell adhesion
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0098754
name: detoxification
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0098796
name: membrane protein complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0098797
name: plasma membrane protein complex
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0098802
name: plasma membrane receptor complex
is_a: GO:0043235 ! receptor complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0098805
name: whole membrane
is_a: GO:0016020 ! membrane

[Term]
id: GO:0098858
name: actin-based cell projection
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0099503
name: secretory vesicle
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:1901135
name: carbohydrate derivative metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:1901137
name: carbohydrate derivative biosynthetic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:1901342
name: regulation of vasculature development
is_a: GO:2000026 ! regulation of multicellular organismal development

[Term]
id: GO:1901360
name: organic cyclic compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:1901362
name: organic cyclic compound biosynthetic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:1901374
name: acetate ester transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:1901564
name: organonitrogen compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:1901566
name: organonitrogen compound biosynthetic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:1901576
name: organic substance biosynthetic process
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:1901615
name: organic hydroxy compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:1901617
name: organic hydroxy compound biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1902105
name: regulation of leukocyte differentiation
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:1903706 ! regulation of hemopoiesis

[Term]
id: GO:1902107
name: positive regulation of leukocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis

[Term]
id: GO:1902578
name: single-organism localization
is_a: GO:0044699 ! single-organism process
is_a: GO:0051179 ! localization

[Term]
id: GO:1902589
name: single-organism organelle organization
is_a: GO:0006996 ! organelle organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:1902622
name: regulation of neutrophil migration
is_a: GO:0002685 ! regulation of leukocyte migration

[Term]
id: GO:1902624
name: positive regulation of neutrophil migration
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:1902622 ! regulation of neutrophil migration

[Term]
id: GO:1903034
name: regulation of response to wounding
is_a: GO:0080134 ! regulation of response to stress

[Term]
id: GO:1903035
name: negative regulation of response to wounding
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding

[Term]
id: GO:1903036
name: positive regulation of response to wounding
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding

[Term]
id: GO:1903037
name: regulation of leukocyte cell-cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion

[Term]
id: GO:1903038
name: negative regulation of leukocyte cell-cell adhesion
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion

[Term]
id: GO:1903039
name: positive regulation of leukocyte cell-cell adhesion
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion

[Term]
id: GO:1903046
name: meiotic cell cycle process
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044702 ! single organism reproductive process

[Term]
id: GO:1903047
name: mitotic cell cycle process
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:1903510
name: mucopolysaccharide metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:1903530
name: regulation of secretion by cell
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0060341 ! regulation of cellular localization

[Term]
id: GO:1903532
name: positive regulation of secretion by cell
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell

[Term]
id: GO:1903706
name: regulation of hemopoiesis
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:2000026 ! regulation of multicellular organismal development

[Term]
id: GO:1903708
name: positive regulation of hemopoiesis
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis

[Term]
id: GO:1904018
name: positive regulation of vasculature development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development

[Term]
id: GO:1990904
name: ribonucleoprotein complex
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:2000026
name: regulation of multicellular organismal development
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process

[Term]
id: GO:2000027
name: regulation of organ morphogenesis
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development

[Term]
id: GO:2000106
name: regulation of leukocyte apoptotic process
is_a: GO:0042981 ! regulation of apoptotic process

[Term]
id: GO:2000145
name: regulation of cell motility
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0051270 ! regulation of cellular component movement

[Term]
id: GO:2000147
name: positive regulation of cell motility
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:2000145 ! regulation of cell motility

[Term]
id: GO:2000514
name: regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation

[Term]
id: GO:2000516
name: positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation

[Term]
id: NCBITaxon:1
name: root
synonym: "all" RELATED []

[Term]
id: NCBITaxon:10066
name: Muridae
is_a: NCBITaxon:337687 ! Muroidea

[Term]
id: NCBITaxon:10088
name: Mus 
synonym: "mice" EXACT []
synonym: "Mus" EXACT []
is_a: NCBITaxon:39107 ! Murinae

[Term]
id: NCBITaxon:10090
name: Mus musculus
synonym: "house mouse" EXACT []
synonym: "mice C57BL/6xCBA/CaJ hybrid" RELATED []
synonym: "mouse" EXACT []
synonym: "Mus muscaris" RELATED []
is_a: NCBITaxon:862507 ! Mus 

[Term]
id: NCBITaxon:10114
name: Rattus
synonym: "rat" EXACT []
synonym: "rats" EXACT []
is_a: NCBITaxon:39107 ! Murinae

[Term]
id: NCBITaxon:10116
name: Rattus norvegicus
synonym: "brown rat" EXACT []
synonym: "Gunn rats" RELATED []
synonym: "Norway rat" EXACT []
synonym: "rat" EXACT []
synonym: "rats" EXACT []
synonym: "Rattus norvegicus8" RELATED []
synonym: "Rattus norwegicus" RELATED []
synonym: "Rattus rattiscus" RELATED []
synonym: "Rattus sp. strain Wistar" EXACT []
is_a: NCBITaxon:10114 ! Rattus

[Term]
id: NCBITaxon:10219
name: Hemichordata
synonym: "hemichordates" EXACT []
synonym: "hemichordates" RELATED []
is_a: NCBITaxon:33511 ! Deuterostomia

[Term]
id: NCBITaxon:104431
name: Obtectomera
is_a: NCBITaxon:37567 ! Ditrysia

[Term]
id: NCBITaxon:105389
name: Palpata
is_a: NCBITaxon:6341 ! Polychaeta

[Term]
id: NCBITaxon:105390
name: Aciculata
is_a: NCBITaxon:105389 ! Palpata

[Term]
id: NCBITaxon:105391
name: Canalipalpata
is_a: NCBITaxon:105389 ! Palpata

[Term]
id: NCBITaxon:110551
name: Myxininae
is_a: NCBITaxon:7762 ! Myxinidae

[Term]
id: NCBITaxon:110555
name: Myxine
is_a: NCBITaxon:110551 ! Myxininae

[Term]
id: NCBITaxon:110814
name: Xenoturbellida
is_a: NCBITaxon:33511 ! Deuterostomia

[Term]
id: NCBITaxon:110815
name: Xenoturbella
is_a: NCBITaxon:110814 ! Xenoturbellida

[Term]
id: NCBITaxon:117565
name: Hyperotreti
synonym: "Agnatha" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
is_a: NCBITaxon:1476529 ! Cyclostomata

[Term]
id: NCBITaxon:117569
name: Hyperoartia
synonym: "Agnatha" RELATED []
synonym: "Cephalaspidomorphi" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
synonym: "Monorhina" RELATED []
is_a: NCBITaxon:1476529 ! Cyclostomata

[Term]
id: NCBITaxon:117570
name: Teleostomi
is_a: NCBITaxon:7776 ! Gnathostomata 

[Term]
id: NCBITaxon:117571
name: Euteleostomi
synonym: "bony vertebrates" EXACT []
is_a: NCBITaxon:117570 ! Teleostomi

[Term]
id: NCBITaxon:117893
name: Batoidea
synonym: "rays" EXACT []
is_a: NCBITaxon:7778 ! Elasmobranchii

[Term]
id: NCBITaxon:118072
name: Coelacanthimorpha
synonym: "Actinistia" RELATED []
synonym: "Choanichthyes" RELATED []
synonym: "Crossopterygii" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
synonym: "lobe-finned fishes" EXACT []
is_a: NCBITaxon:8287 ! Sarcopterygii

[Term]
id: NCBITaxon:119089
name: Chromadorea
synonym: "Adenophorea" RELATED []
is_a: NCBITaxon:6231 ! Nematoda

[Term]
id: NCBITaxon:1206794
name: Ecdysozoa
is_a: NCBITaxon:33317 ! Protostomia

[Term]
id: NCBITaxon:1206795
name: Lophotrochozoa
is_a: NCBITaxon:33317 ! Protostomia

[Term]
id: NCBITaxon:123365
name: Neoteleostei
is_a: NCBITaxon:1489388 ! Euteleosteomorpha

[Term]
id: NCBITaxon:123366
name: Eurypterygia
synonym: "Eurypterygii" RELATED []
is_a: NCBITaxon:123365 ! Neoteleostei

[Term]
id: NCBITaxon:123367
name: Ctenosquamata
is_a: NCBITaxon:123366 ! Eurypterygia

[Term]
id: NCBITaxon:123368
name: Acanthomorphata
synonym: "Acanthomorpha" RELATED []
is_a: NCBITaxon:123367 ! Ctenosquamata

[Term]
id: NCBITaxon:123369
name: Euacanthomorphacea
synonym: "Euacanthomorpha" RELATED []
is_a: NCBITaxon:123368 ! Acanthomorphata

[Term]
id: NCBITaxon:126287
name: Didelphinae
is_a: NCBITaxon:9265 ! Didelphidae

[Term]
id: NCBITaxon:1294634
name: Crocodylia
synonym: "Crocodilia" RELATED []
synonym: "reptiles" RELATED []
synonym: "Reptilia" RELATED []
is_a: NCBITaxon:8492 ! Archosauria

[Term]
id: NCBITaxon:1298654
name: Longirostres
is_a: NCBITaxon:1294634 ! Crocodylia

[Term]
id: NCBITaxon:1312402
name: Xenacoelomorpha
is_a: NCBITaxon:33511 ! Deuterostomia

[Term]
id: NCBITaxon:131567
name: cellular organisms
synonym: "biota" RELATED []
is_a: NCBITaxon:1 ! root

[Term]
id: NCBITaxon:1329799
name: Testudines + Archosauria group
synonym: "Archosauria-Testudines" RELATED []
is_a: NCBITaxon:32561 ! Sauria

[Term]
id: NCBITaxon:1329911
name: Toxicofera
is_a: NCBITaxon:1329912 ! Episquamata

[Term]
id: NCBITaxon:1329912
name: Episquamata
is_a: NCBITaxon:1329950 ! Unidentata

[Term]
id: NCBITaxon:1329950
name: Unidentata
is_a: NCBITaxon:1329961 ! Bifurcata

[Term]
id: NCBITaxon:1329961
name: Bifurcata
synonym: "split-tongued squamates" EXACT []
is_a: NCBITaxon:8509 ! Squamata

[Term]
id: NCBITaxon:133551
name: Eleutherozoa
is_a: NCBITaxon:7586 ! Echinodermata

[Term]
id: NCBITaxon:1338369
name: Dipnotetrapodomorpha
is_a: NCBITaxon:8287 ! Sarcopterygii

[Term]
id: NCBITaxon:13615
name: Monodelphis
synonym: "short-tailed opossums" EXACT []
is_a: NCBITaxon:126287 ! Didelphinae

[Term]
id: NCBITaxon:13616
name: Monodelphis domestica
synonym: "gray short-tailed opossum" EXACT []
synonym: "Monodelphis domesticus" RELATED []
is_a: NCBITaxon:13615 ! Monodelphis

[Term]
id: NCBITaxon:1437010
name: Boreoeutheria
synonym: "Boreotheria" RELATED []
is_a: NCBITaxon:9347 ! Eutheria

[Term]
id: NCBITaxon:147099
name: Acoelomorpha
is_a: NCBITaxon:1312402 ! Xenacoelomorpha

[Term]
id: NCBITaxon:1476529
name: Cyclostomata
synonym: "Agnatha" RELATED []
synonym: "jawless vertebrates" EXACT []
is_a: NCBITaxon:7742 ! Vertebrata 

[Term]
id: NCBITaxon:1489340
name: Elopocephalai
is_a: NCBITaxon:32443 ! Teleostei

[Term]
id: NCBITaxon:1489341
name: Osteoglossocephalai
is_a: NCBITaxon:32443 ! Teleostei

[Term]
id: NCBITaxon:1489343
name: Osteoglossocephala
is_a: NCBITaxon:1489341 ! Osteoglossocephalai

[Term]
id: NCBITaxon:1489388
name: Euteleosteomorpha
is_a: NCBITaxon:186625 ! Clupeocephala

[Term]
id: NCBITaxon:1489872
name: Percomorphaceae
is_a: NCBITaxon:123369 ! Euacanthomorphacea

[Term]
id: NCBITaxon:1489873
name: Ophidiimorpharia
is_a: NCBITaxon:1489872 ! Percomorphaceae

[Term]
id: NCBITaxon:1489908
name: Ovalentaria
synonym: "Stiassnyiformes" RELATED []
is_a: NCBITaxon:1489872 ! Percomorphaceae

[Term]
id: NCBITaxon:1489913
name: Atherinomorphae
synonym: "Atherinomorpha" RELATED []
is_a: NCBITaxon:1489908 ! Ovalentaria

[Term]
id: NCBITaxon:1489922
name: Percomorpharia
is_a: NCBITaxon:1489872 ! Percomorphaceae

[Term]
id: NCBITaxon:181400
name: Bythitoidei
is_a: NCBITaxon:94929 ! Ophidiiformes

[Term]
id: NCBITaxon:182222
name: Muraeninae
is_a: NCBITaxon:46660 ! Muraenidae

[Term]
id: NCBITaxon:186285
name: Drosophiliti
is_a: NCBITaxon:46879 ! Drosophilina

[Term]
id: NCBITaxon:186623
name: Actinopteri
is_a: NCBITaxon:7898 ! Actinopterygii

[Term]
id: NCBITaxon:186624
name: Elopocephala
is_a: NCBITaxon:1489340 ! Elopocephalai

[Term]
id: NCBITaxon:186625
name: Clupeocephala
is_a: NCBITaxon:1489341 ! Osteoglossocephalai

[Term]
id: NCBITaxon:186626
name: Otophysa
synonym: "Otophysi" RELATED []
is_a: NCBITaxon:32519 ! Ostariophysi

[Term]
id: NCBITaxon:186627
name: Cypriniphysae
synonym: "Cypriniphysi" RELATED []
is_a: NCBITaxon:186626 ! Otophysa

[Term]
id: NCBITaxon:186634
name: Otomorpha
synonym: "Ostarioclupeomorpha" RELATED []
synonym: "Otocephala" RELATED []
is_a: NCBITaxon:186625 ! Clupeocephala

[Term]
id: NCBITaxon:189497
name: Echidna
is_a: NCBITaxon:182222 ! Muraeninae

[Term]
id: NCBITaxon:197562
name: Pancrustacea
is_a: NCBITaxon:197563 ! Mandibulata

[Term]
id: NCBITaxon:197563
name: Mandibulata
synonym: "mandibulates" EXACT []
is_a: NCBITaxon:6656 ! Arthropoda

[Term]
id: NCBITaxon:207598
name: Homininae
synonym: "Homo/Pan/Gorilla group" RELATED []
is_a: NCBITaxon:9604 ! Hominidae

[Term]
id: NCBITaxon:262014
name: Xenopus 
synonym: "Xenopus" EXACT []
is_a: NCBITaxon:8353 ! Xenopus 

[Term]
id: NCBITaxon:2759
name: Eukaryota
synonym: "Eucarya" RELATED []
synonym: "Eucaryotae" RELATED []
synonym: "eucaryotes" EXACT []
synonym: "Eukarya" RELATED []
synonym: "Eukaryotae" RELATED []
synonym: "eukaryotes" EXACT []
synonym: "eukaryotes" RELATED []
is_a: NCBITaxon:131567 ! cellular organisms

[Term]
id: NCBITaxon:27592
name: Bovinae
is_a: NCBITaxon:9895 ! Bovidae

[Term]
id: NCBITaxon:28376
name: Anolis
synonym: "Norops" RELATED []
is_a: NCBITaxon:81957 ! Polychrotinae

[Term]
id: NCBITaxon:28377
name: Anolis carolinensis
synonym: "Carolina anole" EXACT []
synonym: "green anole" EXACT []
is_a: NCBITaxon:28376 ! Anolis

[Term]
id: NCBITaxon:28781
name: Adrianichthyoidei
is_a: NCBITaxon:76071 ! Beloniformes

[Term]
id: NCBITaxon:30319
name: Pipoidea
is_a: NCBITaxon:8342 ! Anura

[Term]
id: NCBITaxon:30458
name: Strigiformes
synonym: "owls" EXACT []
is_a: NCBITaxon:8825 ! Neognathae

[Term]
id: NCBITaxon:30577
name: Erinaceinae
synonym: "spiny hedgehogs" EXACT []
is_a: NCBITaxon:9363 ! Erinaceidae

[Term]
id: NCBITaxon:30648
name: Dipodidae
synonym: "jerboas" EXACT []
is_a: NCBITaxon:33553 ! Sciurognathi

[Term]
id: NCBITaxon:30727
name: Cyprinoidea
synonym: "Cyprinoidei" RELATED []
is_a: NCBITaxon:7952 ! Cypriniformes

[Term]
id: NCBITaxon:31022
name: Tetraodontiformes
is_a: NCBITaxon:1489922 ! Percomorpharia

[Term]
id: NCBITaxon:31028
name: Tetraodontoidei
is_a: NCBITaxon:31022 ! Tetraodontiformes

[Term]
id: NCBITaxon:31031
name: Tetraodontidae
synonym: "puffer fishes" EXACT []
synonym: "puffers" EXACT []
is_a: NCBITaxon:32517 ! Tetradontoidea

[Term]
id: NCBITaxon:31032
name: Takifugu
synonym: "Fugu" RELATED []
is_a: NCBITaxon:31031 ! Tetraodontidae

[Term]
id: NCBITaxon:31033
name: Takifugu rubripes
synonym: "Fugu rubripes" RELATED []
synonym: "Sphaeroides rubripes" RELATED []
synonym: "Takifugu rubripes (Temminck & Schlegel, 1850)" RELATED []
synonym: "Tetraodon rubripes" RELATED []
synonym: "tiger puffer" EXACT []
synonym: "torafugu" EXACT []
is_a: NCBITaxon:31032 ! Takifugu

[Term]
id: NCBITaxon:31089
name: Osteoglossomorpha
is_a: NCBITaxon:1489343 ! Osteoglossocephala

[Term]
id: NCBITaxon:311790
name: Afrotheria
is_a: NCBITaxon:9347 ! Eutheria

[Term]
id: NCBITaxon:314145
name: Laurasiatheria
is_a: NCBITaxon:1437010 ! Boreoeutheria

[Term]
id: NCBITaxon:314146
name: Euarchontoglires
is_a: NCBITaxon:1437010 ! Boreoeutheria

[Term]
id: NCBITaxon:314147
name: Glires
synonym: "Rodents and rabbits" EXACT []
is_a: NCBITaxon:314146 ! Euarchontoglires

[Term]
id: NCBITaxon:314293
name: Simiiformes
synonym: "Anthropoidea" RELATED []
is_a: NCBITaxon:376913 ! Haplorrhini

[Term]
id: NCBITaxon:314294
name: Cercopithecoidea
is_a: NCBITaxon:9526 ! Catarrhini

[Term]
id: NCBITaxon:314295
name: Hominoidea
synonym: "ape" EXACT []
synonym: "apes" EXACT []
is_a: NCBITaxon:9526 ! Catarrhini

[Term]
id: NCBITaxon:32341
name: Sophophora
is_a: NCBITaxon:7215 ! Drosophila 

[Term]
id: NCBITaxon:32346
name: melanogaster group
is_a: NCBITaxon:32341 ! Sophophora

[Term]
id: NCBITaxon:32351
name: melanogaster subgroup
is_a: NCBITaxon:32346 ! melanogaster group

[Term]
id: NCBITaxon:32443
name: Teleostei
synonym: "teleost fishes" EXACT []
is_a: NCBITaxon:41665 ! Neopterygii

[Term]
id: NCBITaxon:32517
name: Tetradontoidea
is_a: NCBITaxon:31028 ! Tetraodontoidei

[Term]
id: NCBITaxon:32519
name: Ostariophysi
is_a: NCBITaxon:186634 ! Otomorpha

[Term]
id: NCBITaxon:32521
name: Elopomorpha
is_a: NCBITaxon:186624 ! Elopocephala

[Term]
id: NCBITaxon:32523
name: Tetrapoda
synonym: "tetrapods" EXACT []
is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha

[Term]
id: NCBITaxon:32524
name: Amniota
synonym: "amniotes" EXACT []
is_a: NCBITaxon:32523 ! Tetrapoda

[Term]
id: NCBITaxon:32525
name: Theria 
synonym: "Theria" EXACT []
is_a: NCBITaxon:40674 ! Mammalia

[Term]
id: NCBITaxon:32561
name: Sauria
synonym: "Diapsida" RELATED []
synonym: "diapsids" EXACT []
is_a: NCBITaxon:8457 ! Sauropsida

[Term]
id: NCBITaxon:33154
name: Opisthokonta
synonym: "Fungi/Metazoa group" RELATED []
synonym: "opisthokonts" RELATED []
is_a: NCBITaxon:2759 ! Eukaryota

[Term]
id: NCBITaxon:33208
name: Metazoa
synonym: "Animalia" RELATED []
synonym: "animals" RELATED []
synonym: "metazoans" EXACT []
synonym: "multicellular animals" EXACT []
is_a: NCBITaxon:33154 ! Opisthokonta

[Term]
id: NCBITaxon:33213
name: Bilateria
is_a: NCBITaxon:6072 ! Eumetazoa

[Term]
id: NCBITaxon:33317
name: Protostomia
is_a: NCBITaxon:33213 ! Bilateria

[Term]
id: NCBITaxon:33340
name: Neoptera
is_a: NCBITaxon:7496 ! Pterygota 

[Term]
id: NCBITaxon:33392
name: Endopterygota
synonym: "Holometabola" RELATED []
is_a: NCBITaxon:33340 ! Neoptera

[Term]
id: NCBITaxon:33511
name: Deuterostomia
synonym: "deuterostomes" EXACT []
is_a: NCBITaxon:33213 ! Bilateria

[Term]
id: NCBITaxon:33553
name: Sciurognathi
is_a: NCBITaxon:9989 ! Rodentia

[Term]
id: NCBITaxon:33554
name: Carnivora
synonym: "carnivores" EXACT []
synonym: "carnivores" RELATED []
is_a: NCBITaxon:314145 ! Laurasiatheria

[Term]
id: NCBITaxon:337687
name: Muroidea
is_a: NCBITaxon:33553 ! Sciurognathi

[Term]
id: NCBITaxon:34989
name: Colubroidea
synonym: "Xenophidia" RELATED []
is_a: NCBITaxon:8570 ! Serpentes

[Term]
id: NCBITaxon:35497
name: Suina
synonym: "Artiodactyla" RELATED []
synonym: "Suiformes" RELATED []
is_a: NCBITaxon:91561 ! Cetartiodactyla

[Term]
id: NCBITaxon:35500
name: Pecora
is_a: NCBITaxon:9845 ! Ruminantia

[Term]
id: NCBITaxon:35737
name: Dipodinae
is_a: NCBITaxon:30648 ! Dipodidae

[Term]
id: NCBITaxon:37512
name: Ceriantharia
synonym: "tube anemones" RELATED []
synonym: "tube-dwelling anemones" EXACT []
is_a: NCBITaxon:6102 ! Hexacorallia

[Term]
id: NCBITaxon:37567
name: Ditrysia
is_a: NCBITaxon:41197 ! Heteroneura

[Term]
id: NCBITaxon:37572
name: Papilionoidea
synonym: "butterflies" EXACT []
synonym: "butterflies" RELATED []
is_a: NCBITaxon:104431 ! Obtectomera

[Term]
id: NCBITaxon:376912
name: Tarsiiformes
is_a: NCBITaxon:376913 ! Haplorrhini

[Term]
id: NCBITaxon:376913
name: Haplorrhini
is_a: NCBITaxon:9443 ! Primates

[Term]
id: NCBITaxon:378855
name: Atelidae
is_a: NCBITaxon:9479 ! Platyrrhini

[Term]
id: NCBITaxon:379583
name: Feliformia
is_a: NCBITaxon:33554 ! Carnivora

[Term]
id: NCBITaxon:379584
name: Caniformia
is_a: NCBITaxon:33554 ! Carnivora

[Term]
id: NCBITaxon:38066
name: Alouattinae
is_a: NCBITaxon:378855 ! Atelidae

[Term]
id: NCBITaxon:38605
name: Didelphimorphia
is_a: NCBITaxon:9263 ! Metatheria

[Term]
id: NCBITaxon:38609
name: Diprotodontia
is_a: NCBITaxon:9263 ! Metatheria

[Term]
id: NCBITaxon:39107
name: Murinae
is_a: NCBITaxon:10066 ! Muridae

[Term]
id: NCBITaxon:39820
name: Nereididae
synonym: "Nereidae" RELATED []
synonym: "sandworms" EXACT []
is_a: NCBITaxon:6348 ! Phyllodocida

[Term]
id: NCBITaxon:40150
name: Monodon
is_a: NCBITaxon:9747 ! Monodontidae

[Term]
id: NCBITaxon:40151
name: Monodon monoceros
synonym: "narwhal" EXACT []
is_a: NCBITaxon:40150 ! Monodon

[Term]
id: NCBITaxon:40674
name: Mammalia
synonym: "mammals" EXACT []
synonym: "mammals" RELATED []
is_a: NCBITaxon:32524 ! Amniota

[Term]
id: NCBITaxon:41191
name: Glossata
is_a: NCBITaxon:7088 ! Lepidoptera

[Term]
id: NCBITaxon:41196
name: Neolepidoptera
is_a: NCBITaxon:41191 ! Glossata

[Term]
id: NCBITaxon:41197
name: Heteroneura
is_a: NCBITaxon:41196 ! Neolepidoptera

[Term]
id: NCBITaxon:41324
name: Siboglinidae
synonym: "Frenulata" RELATED []
synonym: "Lamellibrachiidae" RELATED []
synonym: "Obturata" RELATED []
synonym: "Oligobrachiidae" RELATED []
synonym: "Perviata" RELATED []
synonym: "Pogonophora" RELATED []
synonym: "pogonophores" EXACT []
synonym: "Polybrachiidae" RELATED []
synonym: "Sclerolinidae" RELATED []
synonym: "tube worms" EXACT []
synonym: "tube worms" RELATED []
synonym: "Vestimentifera" RELATED []
synonym: "vestimentiferans" EXACT []
is_a: NCBITaxon:6362 ! Sabellida

[Term]
id: NCBITaxon:41665
name: Neopterygii
synonym: "Neopterygi" RELATED []
is_a: NCBITaxon:186623 ! Actinopteri

[Term]
id: NCBITaxon:41666
name: Batrachia
is_a: NCBITaxon:8292 ! Amphibia

[Term]
id: NCBITaxon:41712
name: Osteoglossiformes
is_a: NCBITaxon:31089 ! Osteoglossomorpha

[Term]
id: NCBITaxon:43453
name: Caecilia
is_a: NCBITaxon:8446 ! Caeciliidae

[Term]
id: NCBITaxon:436486
name: Dinosauria
is_a: NCBITaxon:8492 ! Archosauria

[Term]
id: NCBITaxon:436489
name: Saurischia
is_a: NCBITaxon:436486 ! Dinosauria

[Term]
id: NCBITaxon:436491
name: Theropoda
is_a: NCBITaxon:436489 ! Saurischia

[Term]
id: NCBITaxon:436492
name: Coelurosauria
is_a: NCBITaxon:436491 ! Theropoda

[Term]
id: NCBITaxon:43733
name: Muscomorpha
synonym: "Asilomorpha" RELATED []
is_a: NCBITaxon:7203 ! Brachycera

[Term]
id: NCBITaxon:43738
name: Schizophora
is_a: NCBITaxon:480117 ! Cyclorrhapha

[Term]
id: NCBITaxon:43741
name: Acalyptratae
is_a: NCBITaxon:43738 ! Schizophora

[Term]
id: NCBITaxon:43746
name: Ephydroidea
is_a: NCBITaxon:43741 ! Acalyptratae

[Term]
id: NCBITaxon:43845
name: Drosophilinae
is_a: NCBITaxon:7214 ! Drosophilidae

[Term]
id: NCBITaxon:46660
name: Muraenidae
synonym: "moray eels" EXACT []
is_a: NCBITaxon:7933 ! Anguilliformes

[Term]
id: NCBITaxon:46877
name: Drosophilini
is_a: NCBITaxon:43845 ! Drosophilinae

[Term]
id: NCBITaxon:46879
name: Drosophilina
is_a: NCBITaxon:46877 ! Drosophilini

[Term]
id: NCBITaxon:47144
name: Tetraodon
is_a: NCBITaxon:31031 ! Tetraodontidae

[Term]
id: NCBITaxon:47757
name: Adrianichthyidae
is_a: NCBITaxon:28781 ! Adrianichthyoidei

[Term]
id: NCBITaxon:480117
name: Cyclorrhapha
is_a: NCBITaxon:480118 ! Eremoneura

[Term]
id: NCBITaxon:480118
name: Eremoneura
is_a: NCBITaxon:43733 ! Muscomorpha

[Term]
id: NCBITaxon:48867
name: Jaculus
is_a: NCBITaxon:35737 ! Dipodinae

[Term]
id: NCBITaxon:50557
name: Insecta
synonym: "true insects" EXACT []
is_a: NCBITaxon:6960 ! Hexapoda

[Term]
id: NCBITaxon:51337
name: Jaculus jaculus
synonym: "lesser Egyptian jerboa" EXACT []
is_a: NCBITaxon:48867 ! Jaculus

[Term]
id: NCBITaxon:55879
name: Rhabditoidea
is_a: NCBITaxon:6236 ! Rhabditida

[Term]
id: NCBITaxon:55885
name: Peloderinae
is_a: NCBITaxon:6243 ! Rhabditidae

[Term]
id: NCBITaxon:6040
name: Porifera
synonym: "Parazoa" RELATED []
synonym: "sponges" EXACT []
synonym: "sponges" RELATED []
is_a: NCBITaxon:33208 ! Metazoa

[Term]
id: NCBITaxon:6072
name: Eumetazoa
is_a: NCBITaxon:33208 ! Metazoa

[Term]
id: NCBITaxon:6073
name: Cnidaria
synonym: "cnidarians" EXACT []
synonym: "cnidarians" RELATED []
synonym: "Coelenterata" RELATED []
synonym: "coelenterates" EXACT []
is_a: NCBITaxon:6072 ! Eumetazoa

[Term]
id: NCBITaxon:607660
name: Ponginae
is_a: NCBITaxon:9604 ! Hominidae

[Term]
id: NCBITaxon:6101
name: Anthozoa
synonym: "anthozoans" EXACT []
synonym: "anthozoans" RELATED []
is_a: NCBITaxon:6073 ! Cnidaria

[Term]
id: NCBITaxon:6102
name: Hexacorallia
synonym: "Zoantharia" RELATED []
is_a: NCBITaxon:6101 ! Anthozoa

[Term]
id: NCBITaxon:6157
name: Platyhelminthes
synonym: "flatworm" EXACT []
synonym: "flatworms" EXACT []
synonym: "flatworms" RELATED []
is_a: NCBITaxon:33213 ! Bilateria

[Term]
id: NCBITaxon:6178
name: Trematoda
is_a: NCBITaxon:6157 ! Platyhelminthes

[Term]
id: NCBITaxon:6199
name: Cestoda
synonym: "tapeworms" EXACT []
is_a: NCBITaxon:6157 ! Platyhelminthes

[Term]
id: NCBITaxon:6200
name: Eucestoda
is_a: NCBITaxon:6199 ! Cestoda

[Term]
id: NCBITaxon:6201
name: Cyclophyllidea
is_a: NCBITaxon:6200 ! Eucestoda

[Term]
id: NCBITaxon:6208
name: Taeniidae
is_a: NCBITaxon:6201 ! Cyclophyllidea

[Term]
id: NCBITaxon:6209
name: Echinococcus
is_a: NCBITaxon:6208 ! Taeniidae

[Term]
id: NCBITaxon:6211
name: Echinococcus multilocularis
is_a: NCBITaxon:6209 ! Echinococcus

[Term]
id: NCBITaxon:6217
name: Nemertea
synonym: "bootlace worms" EXACT []
synonym: "nemertines" EXACT []
synonym: "Nemertini" RELATED []
synonym: "ribbon worms" EXACT []
synonym: "ribbon worms" RELATED []
is_a: NCBITaxon:1206795 ! Lophotrochozoa

[Term]
id: NCBITaxon:6231
name: Nematoda
synonym: "Nemata" RELATED []
synonym: "nematode" EXACT []
synonym: "nematodes" EXACT []
synonym: "nematodes" RELATED []
synonym: "roundworm" EXACT []
synonym: "roundworms" EXACT []
is_a: NCBITaxon:1206794 ! Ecdysozoa

[Term]
id: NCBITaxon:6236
name: Rhabditida
is_a: NCBITaxon:119089 ! Chromadorea

[Term]
id: NCBITaxon:6237
name: Caenorhabditis
is_a: NCBITaxon:55885 ! Peloderinae

[Term]
id: NCBITaxon:6239
name: Caenorhabditis elegans
synonym: "Rhabditis elegans" RELATED []
synonym: "roundworm" EXACT []
is_a: NCBITaxon:6237 ! Caenorhabditis

[Term]
id: NCBITaxon:6243
name: Rhabditidae
is_a: NCBITaxon:55879 ! Rhabditoidea

[Term]
id: NCBITaxon:6340
name: Annelida
synonym: "annelid worms" EXACT []
synonym: "segmented worms" RELATED []
is_a: NCBITaxon:1206795 ! Lophotrochozoa

[Term]
id: NCBITaxon:6341
name: Polychaeta
synonym: "polychaetes" EXACT []
is_a: NCBITaxon:6340 ! Annelida

[Term]
id: NCBITaxon:6348
name: Phyllodocida
is_a: NCBITaxon:105390 ! Aciculata

[Term]
id: NCBITaxon:6358
name: Platynereis
is_a: NCBITaxon:39820 ! Nereididae

[Term]
id: NCBITaxon:6362
name: Sabellida
is_a: NCBITaxon:105391 ! Canalipalpata

[Term]
id: NCBITaxon:6425
name: Riftia
is_a: NCBITaxon:41324 ! Siboglinidae

[Term]
id: NCBITaxon:6447
name: Mollusca
synonym: "molluscs" EXACT []
synonym: "molluscs" RELATED []
synonym: "mollusks" EXACT []
is_a: NCBITaxon:1206795 ! Lophotrochozoa

[Term]
id: NCBITaxon:6448
name: Gastropoda
synonym: "gastropods" EXACT []
synonym: "gastropods" RELATED []
is_a: NCBITaxon:6447 ! Mollusca

[Term]
id: NCBITaxon:6656
name: Arthropoda
synonym: "arthropods" EXACT []
synonym: "arthropods" RELATED []
is_a: NCBITaxon:88770 ! Panarthropoda

[Term]
id: NCBITaxon:6657
name: Crustacea
synonym: "crustaceans" EXACT []
synonym: "crustaceans" RELATED []
is_a: NCBITaxon:197562 ! Pancrustacea

[Term]
id: NCBITaxon:6830
name: Copepoda
synonym: "copepods" EXACT []
is_a: NCBITaxon:72037 ! Maxillopoda

[Term]
id: NCBITaxon:6843
name: Chelicerata
synonym: "chelicerates" EXACT []
is_a: NCBITaxon:6656 ! Arthropoda

[Term]
id: NCBITaxon:6854
name: Arachnida
synonym: "arachnids" EXACT []
synonym: "arachnids" RELATED []
is_a: NCBITaxon:6843 ! Chelicerata

[Term]
id: NCBITaxon:6960
name: Hexapoda
synonym: "Atelocerata" RELATED []
synonym: "insects" EXACT []
synonym: "insects" RELATED []
synonym: "Tracheata" RELATED []
synonym: "Uniramia" RELATED []
is_a: NCBITaxon:197562 ! Pancrustacea

[Term]
id: NCBITaxon:7088
name: Lepidoptera
synonym: "butterflies and moths" EXACT []
synonym: "moths" EXACT []
synonym: "moths" RELATED []
is_a: NCBITaxon:85604 ! Amphiesmenoptera

[Term]
id: NCBITaxon:7147
name: Diptera
synonym: "flies" EXACT []
synonym: "flies" RELATED []
is_a: NCBITaxon:33392 ! Endopterygota

[Term]
id: NCBITaxon:7203
name: Brachycera
is_a: NCBITaxon:7147 ! Diptera

[Term]
id: NCBITaxon:72037
name: Maxillopoda
is_a: NCBITaxon:6657 ! Crustacea

[Term]
id: NCBITaxon:7214
name: Drosophilidae
synonym: "pomace flies" EXACT []
is_a: NCBITaxon:43746 ! Ephydroidea

[Term]
id: NCBITaxon:7215
name: Drosophila 
synonym: "Drosophila" EXACT []
synonym: "fruit flies" EXACT []
synonym: "fruit fly" EXACT []
is_a: NCBITaxon:186285 ! Drosophiliti

[Term]
id: NCBITaxon:7227
name: Drosophila melanogaster
synonym: "Drosophila melangaster" RELATED []
synonym: "fruit fly" EXACT []
is_a: NCBITaxon:32351 ! melanogaster subgroup

[Term]
id: NCBITaxon:7496
name: Pterygota 
synonym: "Pterygota" EXACT []
synonym: "winged insects" EXACT []
is_a: NCBITaxon:85512 ! Dicondylia

[Term]
id: NCBITaxon:7586
name: Echinodermata
synonym: "echinoderms" EXACT []
synonym: "echinoderms" RELATED []
is_a: NCBITaxon:33511 ! Deuterostomia

[Term]
id: NCBITaxon:76071
name: Beloniformes
is_a: NCBITaxon:1489913 ! Atherinomorphae

[Term]
id: NCBITaxon:7624
name: Echinozoa
is_a: NCBITaxon:133551 ! Eleutherozoa

[Term]
id: NCBITaxon:7625
name: Echinoidea
synonym: "sea urchins" EXACT []
synonym: "sea urchins" RELATED []
is_a: NCBITaxon:7624 ! Echinozoa

[Term]
id: NCBITaxon:7711
name: Chordata
synonym: "chordates" EXACT []
synonym: "chordates" RELATED []
is_a: NCBITaxon:33511 ! Deuterostomia

[Term]
id: NCBITaxon:7712
name: Tunicata
synonym: "tunicates" EXACT []
synonym: "tunicates" RELATED []
synonym: "Urochordata" RELATED []
is_a: NCBITaxon:7711 ! Chordata

[Term]
id: NCBITaxon:7713
name: Ascidiacea
synonym: "sea squirts" EXACT []
is_a: NCBITaxon:7712 ! Tunicata

[Term]
id: NCBITaxon:7735
name: Cephalochordata
synonym: "lancelets" RELATED []
is_a: NCBITaxon:7711 ! Chordata

[Term]
id: NCBITaxon:7736
name: Branchiostomidae
synonym: "amphioxi" EXACT []
synonym: "amphioxius" EXACT []
synonym: "Branchiostomatidae" RELATED []
synonym: "lancelets" EXACT []
is_a: NCBITaxon:7735 ! Cephalochordata

[Term]
id: NCBITaxon:7737
name: Branchiostoma
is_a: NCBITaxon:7736 ! Branchiostomidae

[Term]
id: NCBITaxon:7742
name: Vertebrata 
synonym: "Vertebrata" EXACT []
synonym: "vertebrates" EXACT []
synonym: "vertebrates" RELATED []
is_a: NCBITaxon:89593 ! Craniata 

[Term]
id: NCBITaxon:7745
name: Petromyzontiformes
synonym: "lampreys" RELATED []
synonym: "Petromyzoniformes" RELATED []
is_a: NCBITaxon:117569 ! Hyperoartia

[Term]
id: NCBITaxon:7746
name: Petromyzontidae
synonym: "lampreys" EXACT []
synonym: "Petromyzonidae" RELATED []
is_a: NCBITaxon:7745 ! Petromyzontiformes

[Term]
id: NCBITaxon:7761
name: Myxiniformes
synonym: "hagfishes" RELATED []
synonym: "Myxinoidea" RELATED []
is_a: NCBITaxon:117565 ! Hyperotreti

[Term]
id: NCBITaxon:7762
name: Myxinidae
synonym: "hagfishes" EXACT []
is_a: NCBITaxon:7761 ! Myxiniformes

[Term]
id: NCBITaxon:7769
name: Myxine glutinosa
synonym: "Atlantic hagfish" EXACT []
synonym: "common hagfish" EXACT []
synonym: "hagfish" EXACT []
is_a: NCBITaxon:110555 ! Myxine

[Term]
id: NCBITaxon:7776
name: Gnathostomata 
synonym: "Gnathostomata" EXACT []
synonym: "jawed vertebrates" EXACT []
is_a: NCBITaxon:7742 ! Vertebrata 

[Term]
id: NCBITaxon:7777
name: Chondrichthyes
synonym: "cartilaginous fishes" EXACT []
synonym: "cartilaginous fishes" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
is_a: NCBITaxon:7776 ! Gnathostomata 

[Term]
id: NCBITaxon:7778
name: Elasmobranchii
synonym: "elasmobranchs" EXACT []
synonym: "sharks and rays" RELATED []
is_a: NCBITaxon:7777 ! Chondrichthyes

[Term]
id: NCBITaxon:7863
name: Holocephali
is_a: NCBITaxon:7777 ! Chondrichthyes

[Term]
id: NCBITaxon:7864
name: Chimaeriformes
synonym: "chimaeras" EXACT []
synonym: "chimaeras" RELATED []
is_a: NCBITaxon:7863 ! Holocephali

[Term]
id: NCBITaxon:7878
name: Dipnoi
synonym: "Choanichthyes" RELATED []
synonym: "Dipneusti" RELATED []
synonym: "dipnoans" EXACT []
synonym: "Dipnomorpha" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
synonym: "lungfishes" EXACT []
synonym: "lungfishes" RELATED []
synonym: "Osteichthyes" RELATED []
is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha

[Term]
id: NCBITaxon:7898
name: Actinopterygii
synonym: "Actinopterygi" RELATED []
synonym: "bony fishes" RELATED []
synonym: "fish" EXACT []
synonym: "fishes" EXACT []
synonym: "Osteichthyes" RELATED []
synonym: "ray-finned fishes" EXACT []
is_a: NCBITaxon:117571 ! Euteleostomi

[Term]
id: NCBITaxon:7933
name: Anguilliformes
synonym: "eels" EXACT []
is_a: NCBITaxon:32521 ! Elopomorpha

[Term]
id: NCBITaxon:7952
name: Cypriniformes
is_a: NCBITaxon:186627 ! Cypriniphysae

[Term]
id: NCBITaxon:7953
name: Cyprinidae
is_a: NCBITaxon:30727 ! Cyprinoidea

[Term]
id: NCBITaxon:7954
name: Danio
synonym: "Brachydanio" RELATED []
synonym: "Celestichthys" RELATED []
is_a: NCBITaxon:7953 ! Cyprinidae

[Term]
id: NCBITaxon:7955
name: Danio rerio
synonym: "Brachidanio rerio" RELATED []
synonym: "Brachydanio rerio" RELATED []
synonym: "Brachydanio rerio frankei" RELATED []
synonym: "Cyprinus rerio" RELATED []
synonym: "Cyprinus rerio Hamilton, 1822" RELATED []
synonym: "Danio frankei" RELATED []
synonym: "Danio rerio (Hamilton, 1822)" RELATED []
synonym: "Danio rerio frankei" RELATED []
synonym: "leopard danio" EXACT []
synonym: "zebra danio" EXACT []
synonym: "zebra fish" EXACT []
synonym: "zebrafish" EXACT []
is_a: NCBITaxon:7954 ! Danio

[Term]
id: NCBITaxon:8075
name: Atheriniformes
is_a: NCBITaxon:1489913 ! Atherinomorphae

[Term]
id: NCBITaxon:8088
name: Oryziinae
synonym: "medakas" EXACT []
synonym: "Oryziatinae" RELATED []
synonym: "ricefishes" EXACT []
is_a: NCBITaxon:47757 ! Adrianichthyidae

[Term]
id: NCBITaxon:8089
name: Oryzias
synonym: "Orizias" RELATED []
synonym: "Xenopoecilus" RELATED []
is_a: NCBITaxon:8088 ! Oryziinae

[Term]
id: NCBITaxon:8090
name: Oryzias latipes
synonym: "Japanese medaka" EXACT []
synonym: "Japanese rice fish" EXACT []
synonym: "medaka" EXACT []
synonym: "Orizias latipes" RELATED []
synonym: "Poecilia latipes" RELATED []
is_a: NCBITaxon:8089 ! Oryzias

[Term]
id: NCBITaxon:81957
name: Polychrotinae
synonym: "Anolinae" RELATED []
synonym: "Polychrinae" RELATED []
synonym: "Polychrotidae" RELATED []
is_a: NCBITaxon:8515 ! Iguanidae

[Term]
id: NCBITaxon:8287
name: Sarcopterygii
is_a: NCBITaxon:117571 ! Euteleostomi

[Term]
id: NCBITaxon:8292
name: Amphibia
synonym: "amphibians" EXACT []
synonym: "amphibians" RELATED []
is_a: NCBITaxon:32523 ! Tetrapoda

[Term]
id: NCBITaxon:8293
name: Caudata
synonym: "salamanders" RELATED []
synonym: "Urodela" RELATED []
is_a: NCBITaxon:41666 ! Batrachia

[Term]
id: NCBITaxon:8342
name: Anura
synonym: "anurans" EXACT []
synonym: "frogs" EXACT []
synonym: "frogs & toads" RELATED []
synonym: "frogs and toads" EXACT []
synonym: "Salientia" RELATED []
is_a: NCBITaxon:41666 ! Batrachia

[Term]
id: NCBITaxon:8352
name: Pipidae
synonym: "pipid frogs" EXACT []
synonym: "tongueless frogs" EXACT []
is_a: NCBITaxon:30319 ! Pipoidea

[Term]
id: NCBITaxon:8353
name: Xenopus 
synonym: "Xenopus" EXACT []
is_a: NCBITaxon:8360 ! Xenopodinae

[Term]
id: NCBITaxon:8355
name: Xenopus laevis
synonym: "African clawed frog" EXACT []
synonym: "Bufo laevis" RELATED []
synonym: "clawed frog" EXACT []
synonym: "common platanna" EXACT []
synonym: "platanna" EXACT []
synonym: "Xenopus laevis (Daudin, 1802)" RELATED []
synonym: "Xenopus leavis" RELATED []
is_a: NCBITaxon:262014 ! Xenopus 

[Term]
id: NCBITaxon:8360
name: Xenopodinae
synonym: "Siluraninae" RELATED []
is_a: NCBITaxon:8352 ! Pipidae

[Term]
id: NCBITaxon:8445
name: Gymnophiona
synonym: "caecilians" RELATED []
is_a: NCBITaxon:8292 ! Amphibia

[Term]
id: NCBITaxon:8446
name: Caeciliidae
synonym: "Caeciliinae" RELATED []
synonym: "true caecilians" EXACT []
is_a: NCBITaxon:8445 ! Gymnophiona

[Term]
id: NCBITaxon:8457
name: Sauropsida
synonym: "sauropsids" EXACT []
is_a: NCBITaxon:32524 ! Amniota

[Term]
id: NCBITaxon:8459
name: Testudines
synonym: "anapsid reptiles" EXACT []
synonym: "Anapsida" RELATED []
synonym: "reptiles" RELATED []
synonym: "Reptilia" RELATED []
synonym: "Testudinata" RELATED []
synonym: "turtles" EXACT []
synonym: "turtles" RELATED []
is_a: NCBITaxon:1329799 ! Testudines + Archosauria group

[Term]
id: NCBITaxon:8492
name: Archosauria
is_a: NCBITaxon:1329799 ! Testudines + Archosauria group

[Term]
id: NCBITaxon:8493
name: Crocodylidae
synonym: "crocodiles" RELATED []
synonym: "crocodilians" EXACT []
is_a: NCBITaxon:1298654 ! Longirostres

[Term]
id: NCBITaxon:8504
name: Lepidosauria
synonym: "lepidosaurs" EXACT []
synonym: "lizards" RELATED []
synonym: "reptiles" RELATED []
synonym: "Reptilia" RELATED []
is_a: NCBITaxon:32561 ! Sauria

[Term]
id: NCBITaxon:8505
name: Sphenodontia
synonym: "beaked reptiles" EXACT []
synonym: "Rhynchocephalia" RELATED []
synonym: "rhynchocephalians" EXACT []
synonym: "Rhynchosauria" RELATED []
is_a: NCBITaxon:8504 ! Lepidosauria

[Term]
id: NCBITaxon:8506
name: Sphenodontidae
is_a: NCBITaxon:8505 ! Sphenodontia

[Term]
id: NCBITaxon:8507
name: Sphenodon
is_a: NCBITaxon:8506 ! Sphenodontidae

[Term]
id: NCBITaxon:8508
name: Sphenodon punctatus
synonym: "hatteria" EXACT []
synonym: "Hatteria punctata" RELATED []
synonym: "tuatara" EXACT []
is_a: NCBITaxon:8507 ! Sphenodon

[Term]
id: NCBITaxon:8509
name: Squamata
synonym: "squamates" EXACT []
is_a: NCBITaxon:8504 ! Lepidosauria

[Term]
id: NCBITaxon:8511
name: Iguania
synonym: "iguanian lizards" EXACT []
synonym: "Lacertilia" RELATED []
is_a: NCBITaxon:1329911 ! Toxicofera

[Term]
id: NCBITaxon:8515
name: Iguanidae
synonym: "iguanid lizards" EXACT []
is_a: NCBITaxon:8511 ! Iguania

[Term]
id: NCBITaxon:85512
name: Dicondylia
is_a: NCBITaxon:50557 ! Insecta

[Term]
id: NCBITaxon:85604
name: Amphiesmenoptera
is_a: NCBITaxon:33392 ! Endopterygota

[Term]
id: NCBITaxon:8570
name: Serpentes
synonym: "Ophidia" RELATED []
synonym: "snakes" EXACT []
synonym: "snakes" RELATED []
is_a: NCBITaxon:1329911 ! Toxicofera

[Term]
id: NCBITaxon:8578
name: Colubridae
synonym: "colubrid snakes" EXACT []
is_a: NCBITaxon:34989 ! Colubroidea

[Term]
id: NCBITaxon:862507
name: Mus 
synonym: "Mus" EXACT []
is_a: NCBITaxon:10088 ! Mus 

[Term]
id: NCBITaxon:8782
name: Aves
synonym: "birds" EXACT []
synonym: "birds" RELATED []
is_a: NCBITaxon:436492 ! Coelurosauria

[Term]
id: NCBITaxon:8825
name: Neognathae
is_a: NCBITaxon:8782 ! Aves

[Term]
id: NCBITaxon:8826
name: Anseriformes
is_a: NCBITaxon:8825 ! Neognathae

[Term]
id: NCBITaxon:8827
name: Anhimidae
synonym: "screamers" EXACT []
is_a: NCBITaxon:8826 ! Anseriformes

[Term]
id: NCBITaxon:88770
name: Panarthropoda
is_a: NCBITaxon:1206794 ! Ecdysozoa

[Term]
id: NCBITaxon:89593
name: Craniata 
synonym: "Craniata" EXACT []
is_a: NCBITaxon:7711 ! Chordata

[Term]
id: NCBITaxon:8976
name: Galliformes
synonym: "fowls" EXACT []
is_a: NCBITaxon:8825 ! Neognathae

[Term]
id: NCBITaxon:9005
name: Phasianidae
synonym: "turkeys" EXACT []
is_a: NCBITaxon:8976 ! Galliformes

[Term]
id: NCBITaxon:9030
name: Gallus
is_a: NCBITaxon:9072 ! Phasianinae

[Term]
id: NCBITaxon:9031
name: Gallus gallus
synonym: "bantam" EXACT []
synonym: "chicken" EXACT []
synonym: "chickens" EXACT []
synonym: "Gallus domesticus" RELATED []
synonym: "Gallus gallus domesticus" RELATED []
is_a: NCBITaxon:9030 ! Gallus

[Term]
id: NCBITaxon:9072
name: Phasianinae
is_a: NCBITaxon:9005 ! Phasianidae

[Term]
id: NCBITaxon:91561
name: Cetartiodactyla
synonym: "even-toed ungulates" RELATED []
synonym: "whales, hippos, ruminants, pigs, camels etc." EXACT []
is_a: NCBITaxon:314145 ! Laurasiatheria

[Term]
id: NCBITaxon:9254
name: Prototheria
is_a: NCBITaxon:40674 ! Mammalia

[Term]
id: NCBITaxon:9255
name: Monotremata
synonym: "egg-laying mammals" EXACT []
synonym: "monotremes" RELATED []
is_a: NCBITaxon:9254 ! Prototheria

[Term]
id: NCBITaxon:9256
name: Ornithorhynchidae
is_a: NCBITaxon:9255 ! Monotremata

[Term]
id: NCBITaxon:9257
name: Ornithorhynchus
synonym: "Ornythorhynchus" RELATED []
is_a: NCBITaxon:9256 ! Ornithorhynchidae

[Term]
id: NCBITaxon:9258
name: Ornithorhynchus anatinus
synonym: "duck-billed platypus" EXACT []
synonym: "duckbill platypus" EXACT []
synonym: "Ornythorhynchus anatinus" RELATED []
synonym: "platypus" EXACT []
is_a: NCBITaxon:9257 ! Ornithorhynchus

[Term]
id: NCBITaxon:9259
name: Tachyglossidae
synonym: "echidnas" EXACT []
is_a: NCBITaxon:9255 ! Monotremata

[Term]
id: NCBITaxon:9263
name: Metatheria
synonym: "Marsupialia" RELATED []
synonym: "marsupials" EXACT []
synonym: "marsupials" RELATED []
is_a: NCBITaxon:32525 ! Theria 

[Term]
id: NCBITaxon:9265
name: Didelphidae
synonym: "American opossums" EXACT []
synonym: "opossums" EXACT []
is_a: NCBITaxon:38605 ! Didelphimorphia

[Term]
id: NCBITaxon:9307
name: Macropodidae
is_a: NCBITaxon:38609 ! Diprotodontia

[Term]
id: NCBITaxon:9312
name: Macropus
is_a: NCBITaxon:9307 ! Macropodidae

[Term]
id: NCBITaxon:9321
name: Macropus rufus
synonym: "Megaleia rufa" RELATED []
synonym: "red kangaroo" EXACT []
is_a: NCBITaxon:9312 ! Macropus

[Term]
id: NCBITaxon:9347
name: Eutheria
synonym: "eutherian mammals" EXACT []
synonym: "placental mammals" EXACT []
synonym: "Placentalia" RELATED []
synonym: "placentals" EXACT []
synonym: "placentals" RELATED []
is_a: NCBITaxon:32525 ! Theria 

[Term]
id: NCBITaxon:9348
name: Xenarthra
synonym: "Edentata" RELATED []
is_a: NCBITaxon:9347 ! Eutheria

[Term]
id: NCBITaxon:9359
name: Dasypodidae
synonym: "armadillo" EXACT []
synonym: "armadillos" EXACT []
is_a: NCBITaxon:948951 ! Cingulata

[Term]
id: NCBITaxon:9362
name: Insectivora
synonym: "hedgehogs, shrews, moles and others" EXACT []
synonym: "insectivores" RELATED []
synonym: "Soricomorpha" RELATED []
is_a: NCBITaxon:314145 ! Laurasiatheria

[Term]
id: NCBITaxon:9363
name: Erinaceidae
synonym: "hedgehogs" EXACT []
is_a: NCBITaxon:9362 ! Insectivora

[Term]
id: NCBITaxon:9364
name: Erinaceus
is_a: NCBITaxon:30577 ! Erinaceinae

[Term]
id: NCBITaxon:9365
name: Erinaceus europaeus
synonym: "common hedgehog" EXACT []
synonym: "Erinaceous europaeus" RELATED []
synonym: "Erinaceus europeus" RELATED []
synonym: "European hedgehog" EXACT []
synonym: "western European hedgehog" EXACT []
is_a: NCBITaxon:9364 ! Erinaceus

[Term]
id: NCBITaxon:9373
name: Talpidae
synonym: "moles, shrew-moles, and desmans" EXACT []
is_a: NCBITaxon:9362 ! Insectivora

[Term]
id: NCBITaxon:9397
name: Chiroptera
synonym: "bats" EXACT []
synonym: "bats" RELATED []
is_a: NCBITaxon:314145 ! Laurasiatheria

[Term]
id: NCBITaxon:9443
name: Primates
synonym: "Primata" RELATED []
synonym: "primate" EXACT []
synonym: "primates" RELATED []
is_a: NCBITaxon:314146 ! Euarchontoglires

[Term]
id: NCBITaxon:9475
name: Tarsiidae
synonym: "tarsiers" EXACT []
is_a: NCBITaxon:376912 ! Tarsiiformes

[Term]
id: NCBITaxon:9479
name: Platyrrhini
synonym: "monkey" EXACT []
synonym: "monkeys" EXACT []
synonym: "New World monkeys" EXACT []
is_a: NCBITaxon:314293 ! Simiiformes

[Term]
id: NCBITaxon:948951
name: Cingulata
is_a: NCBITaxon:9348 ! Xenarthra

[Term]
id: NCBITaxon:94929
name: Ophidiiformes
is_a: NCBITaxon:1489873 ! Ophidiimorpharia

[Term]
id: NCBITaxon:9499
name: Alouatta
synonym: "howler monkeys" EXACT []
is_a: NCBITaxon:38066 ! Alouattinae

[Term]
id: NCBITaxon:9526
name: Catarrhini
is_a: NCBITaxon:314293 ! Simiiformes

[Term]
id: NCBITaxon:9527
name: Cercopithecidae
synonym: "monkey" EXACT []
synonym: "monkeys" EXACT []
synonym: "Old World monkeys" EXACT []
is_a: NCBITaxon:314294 ! Cercopithecoidea

[Term]
id: NCBITaxon:9528
name: Cercopithecinae
is_a: NCBITaxon:9527 ! Cercopithecidae

[Term]
id: NCBITaxon:9539
name: Macaca
synonym: "macaque" EXACT []
synonym: "macaques" EXACT []
is_a: NCBITaxon:9528 ! Cercopithecinae

[Term]
id: NCBITaxon:9544
name: Macaca mulatta
synonym: "rhesus macaque" EXACT []
synonym: "rhesus macaques" EXACT []
synonym: "Rhesus monkey" EXACT []
synonym: "rhesus monkeys" EXACT []
is_a: NCBITaxon:9539 ! Macaca

[Term]
id: NCBITaxon:9592
name: Gorilla
is_a: NCBITaxon:207598 ! Homininae

[Term]
id: NCBITaxon:9593
name: Gorilla gorilla
synonym: "gorilla" EXACT []
synonym: "western gorilla" EXACT []
is_a: NCBITaxon:9592 ! Gorilla

[Term]
id: NCBITaxon:9596
name: Pan
synonym: "chimpanzees" EXACT []
is_a: NCBITaxon:207598 ! Homininae

[Term]
id: NCBITaxon:9597
name: Pan paniscus
synonym: "bonobo" EXACT []
synonym: "pygmy chimpanzee" EXACT []
is_a: NCBITaxon:9596 ! Pan

[Term]
id: NCBITaxon:9598
name: Pan troglodytes
synonym: "Chimpansee troglodytes" RELATED []
synonym: "chimpanzee" EXACT []
is_a: NCBITaxon:9596 ! Pan

[Term]
id: NCBITaxon:9599
name: Pongo
is_a: NCBITaxon:607660 ! Ponginae

[Term]
id: NCBITaxon:9600
name: Pongo pygmaeus
synonym: "Bornean orangutan" EXACT []
synonym: "orang utan" EXACT []
synonym: "Orang-utan" EXACT []
synonym: "Orangutan" EXACT []
is_a: NCBITaxon:9599 ! Pongo

[Term]
id: NCBITaxon:9604
name: Hominidae
synonym: "great apes" EXACT []
synonym: "Pongidae" RELATED []
is_a: NCBITaxon:314295 ! Hominoidea

[Term]
id: NCBITaxon:9605
name: Homo
is_a: NCBITaxon:207598 ! Homininae

[Term]
id: NCBITaxon:9606
name: Homo sapiens
synonym: "human" EXACT []
synonym: "man" EXACT []
is_a: NCBITaxon:9605 ! Homo

[Term]
id: NCBITaxon:9608
name: Canidae
synonym: "dog, coyote, wolf, fox" EXACT []
is_a: NCBITaxon:379584 ! Caniformia

[Term]
id: NCBITaxon:9611
name: Canis
is_a: NCBITaxon:9608 ! Canidae

[Term]
id: NCBITaxon:9681
name: Felidae
synonym: "cat family" EXACT []
is_a: NCBITaxon:379583 ! Feliformia

[Term]
id: NCBITaxon:9709
name: Phocidae
synonym: "crawling seals" EXACT []
synonym: "earless seals" EXACT []
synonym: "seal" EXACT []
synonym: "seals" EXACT []
synonym: "true seals" EXACT []
is_a: NCBITaxon:379584 ! Caniformia

[Term]
id: NCBITaxon:9721
name: Cetacea
synonym: "whale" EXACT []
synonym: "whales" EXACT []
synonym: "whales & dolphins" RELATED []
synonym: "whales, dolphins, and porpoises" EXACT []
is_a: NCBITaxon:91561 ! Cetartiodactyla

[Term]
id: NCBITaxon:9722
name: Odontoceti
synonym: "tooth whales" EXACT []
is_a: NCBITaxon:9721 ! Cetacea

[Term]
id: NCBITaxon:9747
name: Monodontidae
is_a: NCBITaxon:9722 ! Odontoceti

[Term]
id: NCBITaxon:9750
name: Physeteridae
synonym: "sperm whales" EXACT []
is_a: NCBITaxon:9722 ! Odontoceti

[Term]
id: NCBITaxon:9753
name: Physeter
is_a: NCBITaxon:9750 ! Physeteridae

[Term]
id: NCBITaxon:9761
name: Mysticeti
synonym: "baleen whales" EXACT []
is_a: NCBITaxon:9721 ! Cetacea

[Term]
id: NCBITaxon:9765
name: Balaenopteridae
synonym: "finback whales" EXACT []
synonym: "rorquals" EXACT []
is_a: NCBITaxon:9761 ! Mysticeti

[Term]
id: NCBITaxon:9779
name: Proboscidea 
synonym: "elephants" EXACT []
synonym: "Proboscidea" EXACT []
is_a: NCBITaxon:311790 ! Afrotheria

[Term]
id: NCBITaxon:9787
name: Perissodactyla
synonym: "odd-toed ungulates" EXACT []
synonym: "odd-toed ungulates" RELATED []
is_a: NCBITaxon:314145 ! Laurasiatheria

[Term]
id: NCBITaxon:9788
name: Equidae
synonym: "horses" EXACT []
is_a: NCBITaxon:9787 ! Perissodactyla

[Term]
id: NCBITaxon:9815
name: Tubulidentata
synonym: "aardvarks" EXACT []
synonym: "Edentata" RELATED []
is_a: NCBITaxon:311790 ! Afrotheria

[Term]
id: NCBITaxon:9816
name: Orycteropodidae
synonym: "aardvark" EXACT []
synonym: "aardvarks" EXACT []
is_a: NCBITaxon:9815 ! Tubulidentata

[Term]
id: NCBITaxon:9821
name: Suidae
synonym: "boars" EXACT []
synonym: "pigs" EXACT []
is_a: NCBITaxon:35497 ! Suina

[Term]
id: NCBITaxon:9822
name: Sus
is_a: NCBITaxon:9821 ! Suidae

[Term]
id: NCBITaxon:9823
name: Sus scrofa
synonym: "pig" EXACT []
synonym: "pigs" EXACT []
synonym: "Sus scrofus" RELATED []
synonym: "swine" EXACT []
synonym: "wild boar" EXACT []
is_a: NCBITaxon:9822 ! Sus

[Term]
id: NCBITaxon:9834
name: Tylopoda
synonym: "Artiodactyla" RELATED []
is_a: NCBITaxon:91561 ! Cetartiodactyla

[Term]
id: NCBITaxon:9835
name: Camelidae
is_a: NCBITaxon:9834 ! Tylopoda

[Term]
id: NCBITaxon:9836
name: Camelus
is_a: NCBITaxon:9835 ! Camelidae

[Term]
id: NCBITaxon:9845
name: Ruminantia
synonym: "Artiodactyla" RELATED []
is_a: NCBITaxon:91561 ! Cetartiodactyla

[Term]
id: NCBITaxon:9850
name: Cervidae
synonym: "deer" EXACT []
is_a: NCBITaxon:35500 ! Pecora

[Term]
id: NCBITaxon:9892
name: Giraffidae
is_a: NCBITaxon:35500 ! Pecora

[Term]
id: NCBITaxon:9895
name: Bovidae
is_a: NCBITaxon:35500 ! Pecora

[Term]
id: NCBITaxon:9903
name: Bos
synonym: "oxen, cattle" EXACT []
is_a: NCBITaxon:27592 ! Bovinae

[Term]
id: NCBITaxon:9913
name: Bos taurus
synonym: "Bos bovis" RELATED []
synonym: "Bos primigenius taurus" RELATED []
synonym: "Bos Tauurus" RELATED []
synonym: "bovine" EXACT []
synonym: "cattle" EXACT []
synonym: "cow" EXACT []
synonym: "domestic cattle" EXACT []
synonym: "domestic cow" EXACT []
is_a: NCBITaxon:9903 ! Bos

[Term]
id: NCBITaxon:9975
name: Lagomorpha
synonym: "rabbits & hares" RELATED []
is_a: NCBITaxon:314147 ! Glires

[Term]
id: NCBITaxon:99883
name: Tetraodon nigroviridis
synonym: "spotted green pufferfish" EXACT []
synonym: "Tetraodon nigroviridis Marion de Proce, 1822" RELATED []
is_a: NCBITaxon:47144 ! Tetraodon

[Term]
id: NCBITaxon:9989
name: Rodentia
synonym: "rodents" EXACT []
synonym: "rodents" RELATED []
is_a: NCBITaxon:314147 ! Glires

[Term]
id: PATO:0000001
name: quality

[Term]
id: PATO:0000050
name: life span
is_a: PATO:0000165 ! time

[Term]
id: PATO:0000051
name: morphology
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0000052
name: shape
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000068
name: qualitative
is_a: PATO:0000001 ! quality

[Term]
id: PATO:0000069
name: deviation(from_normal)
is_a: PATO:0000068 ! qualitative

[Term]
id: PATO:0000117
name: size
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000141
name: structure
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000165
name: time
is_a: PATO:0001018 ! physical quality

[Term]
id: PATO:0000261
name: maturity
is_a: PATO:0001995 ! organismal quality

[Term]
id: PATO:0000406
name: curved
is_a: PATO:0001591 ! curvature

[Term]
id: PATO:0000460
name: abnormal
is_a: PATO:0000069 ! deviation(from_normal)

[Term]
id: PATO:0000586
name: increased size
is_a: PATO:0000117 ! size
is_a: PATO:0002305 ! increased object quality

[Term]
id: PATO:0000587
name: decreased size
is_a: PATO:0000117 ! size
is_a: PATO:0002303 ! decreased object quality

[Term]
id: PATO:0001018
name: physical quality
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0001241
name: physical object quality
is_a: PATO:0000001 ! quality

[Term]
id: PATO:0001367
name: lobate
is_a: PATO:0001925 ! surface feature shape

[Term]
id: PATO:0001374
name: ploidy
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001375
name: haploid
is_a: PATO:0001393 ! euploid

[Term]
id: PATO:0001393
name: euploid
is_a: PATO:0001374 ! ploidy

[Term]
id: PATO:0001394
name: diploid
is_a: PATO:0001393 ! euploid

[Term]
id: PATO:0001396
name: cellular quality
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0001397
name: cellular potency
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001400
name: unipotent
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001401
name: oligopotent
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001402
name: multipotent
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001404
name: nucleate quality
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001405
name: anucleate
is_a: PATO:0001404 ! nucleate quality

[Term]
id: PATO:0001406
name: binucleate
is_a: PATO:0001908 ! multinucleate

[Term]
id: PATO:0001407
name: mononucleate
is_a: PATO:0002505 ! nucleated

[Term]
id: PATO:0001410
name: striated
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001501
name: immature
is_a: PATO:0000261 ! maturity

[Term]
id: PATO:0001591
name: curvature
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001604
name: decreased life span
is_a: PATO:0000050 ! life span
is_a: PATO:0002303 ! decreased object quality

[Term]
id: PATO:0001789
name: domed
is_a: PATO:0000406 ! curved

[Term]
id: PATO:0001857
name: concave
is_a: PATO:0002005 ! concavity

[Term]
id: PATO:0001871
name: reniform
is_a: PATO:0002008 ! concave 3-D shape

[Term]
id: PATO:0001873
name: cylindrical
is_a: PATO:0002007 ! convex 3-D shape

[Term]
id: PATO:0001874
name: discoid
is_a: PATO:0001873 ! cylindrical

[Term]
id: PATO:0001908
name: multinucleate
is_a: PATO:0002505 ! nucleated

[Term]
id: PATO:0001925
name: surface feature shape
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001979
name: lobed
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001995
name: organismal quality
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0002005
name: concavity
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0002007
name: convex 3-D shape
is_a: PATO:0002266 ! 3-D shape

[Term]
id: PATO:0002008
name: concave 3-D shape
is_a: PATO:0002266 ! 3-D shape

[Term]
id: PATO:0002011
name: neoplastic
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0002039
name: biconcave
is_a: PATO:0001857 ! concave

[Term]
id: PATO:0002070
name: affinity
is_a: PATO:0002182 ! molecular quality

[Term]
id: PATO:0002094
name: basophilic
is_a: PATO:0002070 ! affinity

[Term]
id: PATO:0002097
name: neoplastic, malignant
is_a: PATO:0002011 ! neoplastic

[Term]
id: PATO:0002182
name: molecular quality
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0002266
name: 3-D shape
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0002300
name: increased quality
is_a: PATO:0000069 ! deviation(from_normal)

[Term]
id: PATO:0002301
name: decreased quality
is_a: PATO:0000069 ! deviation(from_normal)

[Term]
id: PATO:0002303
name: decreased object quality
is_a: PATO:0001241 ! physical object quality
is_a: PATO:0002301 ! decreased quality

[Term]
id: PATO:0002305
name: increased object quality
is_a: PATO:0001241 ! physical object quality
is_a: PATO:0002300 ! increased quality

[Term]
id: PATO:0002478
name: transversely striated
is_a: PATO:0001410 ! striated

[Term]
id: PATO:0002479
name: obliquely striated
is_a: PATO:0001410 ! striated

[Term]
id: PATO:0002505
name: nucleated
is_a: PATO:0001404 ! nucleate quality

[Term]
id: PATO:0002506
name: alobate
is_a: PATO:0001925 ! surface feature shape

[Term]
id: PR:000000001
name: protein
def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA." []
is_a: PR:000018263 ! amino acid chain

[Term]
id: PR:000001002
name: CD19 molecule
def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." []
synonym: "B-lymphocyte surface antigen B4" EXACT []
synonym: "CD19" EXACT []
synonym: "differentiation antigen CD19" EXACT []
synonym: "T-cell surface antigen Leu-12" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001003
name: CD34 molecule
def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." []
synonym: "CD34" EXACT []
synonym: "hematopoietic progenitor cell antigen CD34" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001004
name: CD4 molecule
def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." []
synonym: "CD4" EXACT []
synonym: "T-cell differentiation antigen L3T4" EXACT []
synonym: "T-cell surface antigen T4/Leu-3" EXACT []
synonym: "T-cell surface glycoprotein CD4" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001005
name: integrin alpha with A domain
def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." []
synonym: "integrin alpha with I domain" EXACT []
is_a: PR:000025796 ! integrin alpha

[Term]
id: PR:000001006
name: receptor-type tyrosine-protein phosphatase C
def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." []
synonym: "CD45" EXACT []
synonym: "L-CA" EXACT []
synonym: "leukocyte common antigen" EXACT []
synonym: "ly-5" EXACT []
synonym: "lymphocyte antigen 5" EXACT []
synonym: "PTPRC" EXACT []
synonym: "T200" BROAD []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001008
name: integrin alpha-2
def: "An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof." []
synonym: "CD49 antigen-like family member B" EXACT []
synonym: "CD49b" EXACT []
synonym: "collagen receptor" EXACT []
synonym: "GPIa" EXACT []
synonym: "ITGA2" EXACT []
synonym: "platelet membrane glycoprotein Ia" EXACT []
synonym: "VLA-2 subunit alpha" EXACT []
is_a: PR:000001005 ! integrin alpha with A domain

[Term]
id: PR:000001010
name: integrin alpha-E
def: "An integrin alpha with A domain that is a translation product of the human ITGAE gene or a 1:1 ortholog thereof." []
synonym: "CD103" EXACT []
synonym: "HML-1 antigen" EXACT []
synonym: "integrin alpha M290" EXACT []
synonym: "integrin alpha-IEL" EXACT []
synonym: "ITGAE" EXACT []
synonym: "mucosal lymphocyte 1 antigen" EXACT []
is_a: PR:000001005 ! integrin alpha with A domain

[Term]
id: PR:000001012
name: integrin alpha-M
def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." []
synonym: "CD11 antigen-like family member B" EXACT []
synonym: "CD11b" EXACT []
synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT []
synonym: "CR-3 alpha chain" EXACT []
synonym: "CR3A" RELATED []
synonym: "ITGAM" EXACT []
synonym: "leukocyte adhesion receptor MO1" EXACT []
synonym: "neutrophil adherence receptor" EXACT []
is_a: PR:000001005 ! integrin alpha with A domain

[Term]
id: PR:000001013
name: integrin alpha-X
def: "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." []
synonym: "CD11 antigen-like family member C" EXACT []
synonym: "CD11c" EXACT []
synonym: "ITGAX" EXACT []
synonym: "Leu M5" EXACT []
synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT []
synonym: "leukocyte adhesion receptor p150,95" EXACT []
is_a: PR:000001005 ! integrin alpha with A domain

[Term]
id: PR:000001014
name: receptor-type tyrosine-protein phosphatase C isoform CD45R
def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-1." []
synonym: "B220" RELATED []
synonym: "CD45R" EXACT []
synonym: "CD45RABC" EXACT []
synonym: "PTPRC/iso:CD45R" EXACT []
is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C

[Term]
id: PR:000001015
name: receptor-type tyrosine-protein phosphatase C isoform CD45RA
def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C)." []
synonym: "CD45RA" EXACT []
synonym: "PTPRC/iso:CD45RA" EXACT []
is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C

[Term]
id: PR:000001017
name: receptor-type tyrosine-protein phosphatase C isoform CD45RO
def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-2." []
synonym: "180 kDa form" EXACT []
synonym: "PTPRC/iso:CD45RO" EXACT []
synonym: "T200" RELATED []
is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C

[Term]
id: PR:000001018
name: CD3 subunit with immunoglobulin domain
def: "A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." []
synonym: "CD3 subunit with Ig-like domain" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001020
name: CD3 epsilon
def: "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." []
synonym: "CD3E" EXACT []
synonym: "CD3e" EXACT []
synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT []
synonym: "T3E" RELATED []
is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain

[Term]
id: PR:000001022
name: neural cell adhesion molecule
def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001023
name: neural cell adhesion molecule NCAM
def: "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." []
is_a: PR:000001022 ! neural cell adhesion molecule

[Term]
id: PR:000001024
name: neural cell adhesion molecule 1
def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." []
synonym: "CD56" EXACT []
synonym: "N-CAM-1" EXACT []
synonym: "NCAM" RELATED []
synonym: "NCAM-1" EXACT []
synonym: "NCAM1" EXACT []
is_a: PR:000001023 ! neural cell adhesion molecule NCAM

[Term]
id: PR:000001025
name: C-type lectin with multiple lectin domains
def: "A protein that is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single Fibronectin type II (FNII) domain (Pfam:PF00040) and eight to ten copies of the Lectin C-type domain (Pfam:PF00059) (CTLDs). The presence of multiple copies of the CTLD domain is a hallmark of this class." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001026
name: lymphocyte antigen 75
def: "A C-type lectin with multiple lectin domains that is a translation product of the human LY75 gene or a 1:1 ortholog thereof. It consists of 12 extracellular domains (an N-terminal cysteine-rich domain, a fibronectin type II domain and 10 C-type carbohydrate recognition domains), a transmembrane region and a small cytoplasmic C terminus containing a single Tyr residue, but no obvious kinase domain. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment." []
synonym: "C-type lectin domain family 13 member B" EXACT []
synonym: "CD205" EXACT []
synonym: "CLEC13B" RELATED []
synonym: "DEC-205" EXACT []
synonym: "gp200-MR6" EXACT []
synonym: "ly-75" EXACT []
synonym: "LY75" EXACT []
is_a: PR:000001025 ! C-type lectin with multiple lectin domains

[Term]
id: PR:000001083
name: CD2 molecule
def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." []
synonym: "CD2" EXACT []
synonym: "erythrocyte receptor" EXACT []
synonym: "LFA-2" EXACT []
synonym: "LFA-3 receptor" EXACT []
synonym: "ly-37" EXACT []
synonym: "lymphocyte antigen 37" EXACT []
synonym: "rosette receptor" EXACT []
synonym: "SRBC" RELATED []
synonym: "T-cell surface antigen CD2" EXACT []
synonym: "T-cell surface antigen T11/Leu-5" EXACT []
synonym: "T-cell surface glycoprotein CD2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001084
name: T-cell surface glycoprotein CD8 alpha chain
def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." []
synonym: "CD8A" EXACT []
synonym: "CD8a" EXACT []
synonym: "Lyt-2" RELATED []
synonym: "Lyt2" RELATED []
synonym: "MAL" RELATED []
synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001087
name: adhesion G-protein coupled receptor
def: "A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs." []
synonym: "fam:adhesion" EXACT []
synonym: "secretin receptor-like G-protein coupled receptor" RELATED []
synonym: "subfamily B2 G-protein coupled receptor" EXACT []
is_a: PR:000030035 ! G-protein coupled receptor

[Term]
id: PR:000001094
name: rhodopsin-like G-protein coupled receptor
def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." []
synonym: "class 1 G-protein coupled receptor" EXACT []
synonym: "fam:rhodopsin" EXACT []
is_a: PR:000030035 ! G-protein coupled receptor

[Term]
id: PR:000001128
name: chemokine receptor
def: "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines. Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list." []
is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor

[Term]
id: PR:000001197
name: chemokine receptor CCR1/3/1L
def: "A chemokine receptor that is a translation product of the CCR1, CCR3, or CCR1L1 genes (the last found so far only in mouse)." []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001199
name: C-C chemokine receptor type 2
def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." []
synonym: "C-C CKR-2" EXACT []
synonym: "CC-CKR-2" EXACT []
synonym: "CCR-2" EXACT []
synonym: "CCR2" EXACT []
synonym: "CD192" EXACT []
synonym: "chemokine receptor CCR2" EXACT []
synonym: "CMKBR2" RELATED []
synonym: "JE/FIC receptor" EXACT []
synonym: "MCP-1 receptor" EXACT []
synonym: "MCP-1-R" EXACT []
synonym: "monocyte chemoattractant protein 1 receptor" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001200
name: C-C chemokine receptor type 4
def: "A chemokine receptor that is a translation product of the human CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22." []
synonym: "C-C CKR-4" EXACT []
synonym: "CC-CKR-4" EXACT []
synonym: "CCR-4" EXACT []
synonym: "CCR4" EXACT []
synonym: "CD194" EXACT []
synonym: "chemokine receptor CCR4" EXACT []
synonym: "CMKBR4" RELATED []
synonym: "K5-5" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001201
name: C-C chemokine receptor type 5
def: "A chemokine receptor that is a translation product of the human CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14." []
synonym: "C-C CKR-5" EXACT []
synonym: "CC-CKR-5" EXACT []
synonym: "CCR-5" EXACT []
synonym: "CCR5" EXACT []
synonym: "CD195" EXACT []
synonym: "chemokine receptor CCR5" EXACT []
synonym: "CHEMR13" EXACT []
synonym: "CMKBR5" RELATED []
synonym: "HIV-1 fusion coreceptor" EXACT []
synonym: "MIP-1 alpha receptor" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001202
name: C-C chemokine receptor type 6
def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." []
synonym: "C-C CKR-6" EXACT []
synonym: "CC-CKR-6" EXACT []
synonym: "CCR-6" EXACT []
synonym: "CCR6" EXACT []
synonym: "CD196" EXACT []
synonym: "chemokine receptor CCR6" EXACT []
synonym: "chemokine receptor-like 3" EXACT []
synonym: "CKR-L3" EXACT []
synonym: "CKRL3" RELATED []
synonym: "CMKBR6" RELATED []
synonym: "DRY6" EXACT []
synonym: "G-protein coupled receptor 29" EXACT []
synonym: "GPR-CY4" EXACT []
synonym: "GPR29" RELATED []
synonym: "GPRCY4" EXACT []
synonym: "KY411" EXACT []
synonym: "LARC receptor" EXACT []
synonym: "STRL22" RELATED []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001203
name: C-C chemokine receptor type 7
def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." []
synonym: "BLR2" EXACT []
synonym: "C-C CKR-7" EXACT []
synonym: "CC-CKR-7" EXACT []
synonym: "CCR-7" EXACT []
synonym: "CCR7" EXACT []
synonym: "CD197" EXACT []
synonym: "CDw197" EXACT []
synonym: "chemokine receptor CCR7" EXACT []
synonym: "CMKBR7" RELATED []
synonym: "EBI1" EXACT []
synonym: "Ebi1h" RELATED []
synonym: "EBV-induced G-protein coupled receptor 1" EXACT []
synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT []
synonym: "EVI1" RELATED []
synonym: "MIP-3 beta receptor" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001206
name: CX3C chemokine receptor 1
def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." []
synonym: "beta chemokine receptor-like 1" EXACT []
synonym: "C-X3-C CKR-1" EXACT []
synonym: "chemokine receptor CX3CR1" EXACT []
synonym: "CMK-BRL-1" EXACT []
synonym: "CMK-BRL1" EXACT []
synonym: "CMKBRL1" RELATED []
synonym: "CX3CR1" EXACT []
synonym: "fractalkine receptor" EXACT []
synonym: "G-protein coupled receptor 13" EXACT []
synonym: "GPR13" RELATED []
synonym: "V28" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001207
name: C-X-C chemokine receptor type 3
def: "A chemokine receptor that is a translation product of the human CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11." []
synonym: "CD183" EXACT []
synonym: "chemokine receptor CXCR3" EXACT []
synonym: "CKR-L2" EXACT []
synonym: "Cmkar3" RELATED []
synonym: "CXC-R3" EXACT []
synonym: "CXCR-3" EXACT []
synonym: "CXCR3" EXACT []
synonym: "G-protein coupled receptor 9" EXACT []
synonym: "GPR9" RELATED []
synonym: "interferon-inducible protein 10 receptor" EXACT []
synonym: "IP-10 receptor" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001208
name: C-X-C chemokine receptor type 4
def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." []
synonym: "CD184" EXACT []
synonym: "chemokine receptor CXCR4" EXACT []
synonym: "Cmkar4" RELATED []
synonym: "CXC-R4" EXACT []
synonym: "CXCR-4" EXACT []
synonym: "CXCR4" EXACT []
synonym: "FB22" EXACT []
synonym: "fusin" EXACT []
synonym: "HM89" EXACT []
synonym: "LCR1" EXACT []
synonym: "LESTR" EXACT []
synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT []
synonym: "NPYRL" EXACT []
synonym: "PB-CKR" EXACT []
synonym: "pre-B-cell-derived chemokine receptor" EXACT []
synonym: "SDF-1 receptor" EXACT []
synonym: "Sdf1r" RELATED []
synonym: "stromal cell-derived factor 1 receptor" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001209
name: C-X-C chemokine receptor type 5
def: "A chemokine receptor that is a translation product of the human CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13." []
synonym: "BLR1" RELATED []
synonym: "burkitt lymphoma receptor 1" EXACT []
synonym: "burkitt lymphoma receptor 1 homolog" EXACT []
synonym: "CD185" EXACT []
synonym: "chemokine receptor CXCR5" EXACT []
synonym: "CXC-R5" EXACT []
synonym: "CXCR-5" EXACT []
synonym: "CXCR5" EXACT []
synonym: "Gpcr6" RELATED []
synonym: "MDR-15" EXACT []
synonym: "MDR15" RELATED []
synonym: "monocyte-derived receptor 15" EXACT []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001226
name: high affinity interleukin-8 receptor
def: "A chemokine receptor whose active form binds interleukin-8 with high affinity." []
is_a: PR:000001128 ! chemokine receptor

[Term]
id: PR:000001254
name: C-C chemokine receptor type 1
def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." []
synonym: "C-C CKR-1" EXACT []
synonym: "CC-CKR-1" EXACT []
synonym: "CCR-1" EXACT []
synonym: "CCR1" EXACT []
synonym: "CD191" EXACT []
synonym: "chemokine receptor CCR1" EXACT []
synonym: "CMKBR1" RELATED []
synonym: "CMKR1" RELATED []
synonym: "HM145" EXACT []
synonym: "LD78 receptor" EXACT []
synonym: "macrophage inflammatory protein 1-alpha receptor" EXACT []
synonym: "MIP-1alpha-R" EXACT []
synonym: "RANTES-R" EXACT []
synonym: "SCYAR1" RELATED []
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L

[Term]
id: PR:000001255
name: C-C chemokine receptor type 3
def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." []
synonym: "C-C CKR-3" EXACT []
synonym: "CC-CKR-3" EXACT []
synonym: "CCR-3" EXACT []
synonym: "CCR3" EXACT []
synonym: "CD193" EXACT []
synonym: "chemokine receptor CCR3" EXACT []
synonym: "CKR3" EXACT []
synonym: "Cmkbr1l2" RELATED []
synonym: "CMKBR3" RELATED []
synonym: "eosinophil eotaxin receptor" EXACT []
synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT []
synonym: "MIP-1 alpha RL2" EXACT []
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L

[Term]
id: PR:000001256
name: C-X-C chemokine receptor type 1
def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR1 gene or a 1:1 ortholog thereof." []
synonym: "CD181" EXACT []
synonym: "CDw128a" EXACT []
synonym: "CMKAR1" RELATED []
synonym: "CXC-R1" EXACT []
synonym: "CXCR-1" EXACT []
synonym: "CXCR1" EXACT []
synonym: "high affinity interleukin-8 receptor A" EXACT []
synonym: "IL-8 receptor type 1" EXACT []
synonym: "IL-8R A" EXACT []
synonym: "IL8RA" RELATED []
is_a: PR:000001226 ! high affinity interleukin-8 receptor

[Term]
id: PR:000001257
name: C-X-C chemokine receptor type 2
def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR2 gene or a 1:1 ortholog thereof." []
synonym: "CD182" EXACT []
synonym: "CDw128b" EXACT []
synonym: "Cmkar2" RELATED []
synonym: "CXC-R2" EXACT []
synonym: "CXCR-2" EXACT []
synonym: "CXCR2" EXACT []
synonym: "Gpcr16" RELATED []
synonym: "GRO/MGSA receptor" EXACT []
synonym: "high affinity interleukin-8 receptor B" EXACT []
synonym: "IL-8 receptor type 2" EXACT []
synonym: "IL-8R B" EXACT []
synonym: "IL8RB" RELATED []
is_a: PR:000001226 ! high affinity interleukin-8 receptor

[Term]
id: PR:000001281
name: ADP-ribosyl cyclase
def: "A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001288
name: B-cell receptor CD22
def: "A protein that is a translation product of the human CD22 gene or a 1:1 ortholog thereof." []
synonym: "B-lymphocyte cell adhesion molecule" EXACT []
synonym: "BL-CAM" EXACT []
synonym: "CD22" EXACT []
synonym: "Lyb-8" RELATED []
synonym: "sialic acid-binding Ig-like lectin 2" EXACT []
synonym: "siglec-2" EXACT []
synonym: "SIGLEC2" RELATED []
synonym: "T-cell surface antigen Leu-14" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001289
name: membrane-spanning 4-domains subfamily A member 1
def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." []
synonym: "B-cell differentiation antigen Ly-44" EXACT []
synonym: "B-cell surface antigen CD20" EXACT []
synonym: "B-lymphocyte antigen CD20" EXACT []
synonym: "B-lymphocyte surface antigen B1" EXACT []
synonym: "Bp35" EXACT []
synonym: "CD20" EXACT []
synonym: "leukocyte surface antigen Leu-16" EXACT []
synonym: "Ly-44" RELATED []
synonym: "lymphocyte antigen 44" EXACT []
synonym: "MS4A1" EXACT []
synonym: "Ms4a2" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001290
name: B7-related protein
def: "A protein that is a member of a family that includes translation products of genes CD86, CD276, ICOSLG, and others. These are membrane-anchored proteins with a small intracellular domain and an extracellular domain with signal sequence, an Immunoglobulin V-set domain (Pfam:PF07686), and a CD80-like C2-set immunoglobulin domain (Pfam:PF08205)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001292
name: C-type lectin domain family 4 member C
def: "A protein that is a translation product of the human CLEC4C gene or a 1:1 ortholog thereof." []
synonym: "BDCA-2" EXACT []
synonym: "BDCA2" RELATED []
synonym: "blood dendritic cell antigen 2" EXACT []
synonym: "C-type lectin superfamily member 7" EXACT []
synonym: "CD303" EXACT []
synonym: "CLEC4C" EXACT []
synonym: "CLECSF11" RELATED []
synonym: "CLECSF7" RELATED []
synonym: "dendritic lectin" EXACT []
synonym: "DLEC" RELATED []
synonym: "HECL" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001293
name: C-type lectin domain family 4 member K
def: "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." []
synonym: "CD207" EXACT []
synonym: "CLEC4K" RELATED []
synonym: "langerin" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001300
name: CD209 molecule
def: "A protein that is a translation product of the human CD209 gene or a 1:1 ortholog thereof." []
synonym: "C-type lectin domain family 4 member L" EXACT []
synonym: "CD209" EXACT []
synonym: "CD209 antigen" EXACT []
synonym: "CLEC4L" RELATED []
synonym: "DC-SIGN" RELATED []
synonym: "DC-SIGN1" EXACT []
synonym: "dendritic cell-specific ICAM-3-grabbing non-integrin 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001307
name: CD44 molecule
def: "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." []
synonym: "CD44" EXACT []
synonym: "CD44 antigen" EXACT []
synonym: "CDw44" EXACT []
synonym: "ECMR-III" EXACT []
synonym: "epican" EXACT []
synonym: "extracellular matrix receptor III" EXACT []
synonym: "GP90 lymphocyte homing/adhesion receptor" EXACT []
synonym: "heparan sulfate proteoglycan" EXACT []
synonym: "hermes antigen" EXACT []
synonym: "HUTCH-I" EXACT []
synonym: "hyaluronate receptor" EXACT []
synonym: "LHR" RELATED []
synonym: "ly-24" EXACT []
synonym: "lymphocyte antigen 24" EXACT []
synonym: "MDU2" RELATED []
synonym: "MDU3" RELATED []
synonym: "MIC4" RELATED []
synonym: "PGP-1" EXACT []
synonym: "PGP-I" RELATED []
synonym: "phagocytic glycoprotein 1" EXACT []
synonym: "phagocytic glycoprotein I" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001308
name: CD48 molecule
def: "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." []
synonym: "B-lymphocyte activation marker BLAST-1" EXACT []
synonym: "Bcm-1" RELATED []
synonym: "BCM1" RELATED []
synonym: "BCM1 surface antigen" EXACT []
synonym: "BLAST-1" EXACT []
synonym: "BLAST1" RELATED []
synonym: "CD48" EXACT []
synonym: "CD48 antigen" EXACT []
synonym: "HM48-1" EXACT []
synonym: "leukocyte antigen MEM-102" EXACT []
synonym: "MRC OX-45 surface antigen" EXACT []
synonym: "sgp-60" EXACT []
synonym: "TCT.1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001310
name: CD83 molecule
def: "A protein that is a translation product of the human CD83 gene or a 1:1 ortholog thereof." []
synonym: "B-cell activation protein" EXACT []
synonym: "CD83" EXACT []
synonym: "CD83 antigen" EXACT []
synonym: "cell surface protein HB15" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001318
name: L-selectin
def: "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." []
synonym: "CD62 antigen-like family member L" EXACT []
synonym: "CD62L" EXACT []
synonym: "gp90-MEL" EXACT []
synonym: "LAM-1" EXACT []
synonym: "LECAM1" EXACT []
synonym: "leukocyte adhesion molecule 1" EXACT []
synonym: "leukocyte surface antigen Leu-8" EXACT []
synonym: "leukocyte-endothelial cell adhesion molecule 1" EXACT []
synonym: "LNHR" RELATED []
synonym: "ly-22" EXACT []
synonym: "Ly22" RELATED []
synonym: "LYAM1" RELATED []
synonym: "lymph node homing receptor" EXACT []
synonym: "lymphocyte antigen 22" EXACT []
synonym: "lymphocyte surface MEL-14 antigen" EXACT []
synonym: "SELL" EXACT []
synonym: "TQ1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001319
name: SLAM family member 5
def: "A protein that is a translation product of the human CD84 gene or a 1:1 ortholog thereof." []
synonym: "CD84" EXACT []
synonym: "cell surface antigen MAX.3" EXACT []
synonym: "hly9-beta" EXACT []
synonym: "leukocyte differentiation antigen CD84" EXACT []
synonym: "signaling lymphocytic activation molecule 5" EXACT []
synonym: "SLAMF5" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001320
name: alpha-(1,3)-fucosyltransferase
def: "A protein that is a stand alone version of the Glycosyltransferase family 10 (fucosyltransferase) (Pfam:PF00852) domain. Proteins in this class may catalyze alpha-1,3 glycosidic linkages." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001326
name: bone marrow stromal antigen 2
def: "A protein that is a translation product of the human BST2 gene or a 1:1 ortholog thereof." []
synonym: "BST-2" EXACT []
synonym: "BST2" EXACT []
synonym: "CD317" EXACT []
synonym: "HM1.24 antigen" EXACT []
synonym: "tetherin" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001327
name: cadherin
def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001332
name: carcinoembryonic antigen-related cell adhesion molecule 8
def: "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." []
synonym: "carcinoembryonic antigen CGM6" EXACT []
synonym: "CD66b" EXACT []
synonym: "CD67 antigen" EXACT []
synonym: "CEACAM8" EXACT []
synonym: "CGM6" RELATED []
synonym: "non-specific cross-reacting antigen NCA-95" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001337
name: complement receptor type 1
def: "A protein that is a translation product of the human CR1 gene or a 1:1 ortholog thereof. There is no counterpart in mouse." []
synonym: "C3b/C4b receptor" EXACT []
synonym: "C3BR" RELATED []
synonym: "CD35" EXACT []
synonym: "CR1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001338
name: complement receptor type 2
def: "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." []
synonym: "C3DR" RELATED []
synonym: "CD21" EXACT []
synonym: "complement C3d receptor" EXACT []
synonym: "CR2" EXACT []
synonym: "Cr2" EXACT []
synonym: "EBV receptor" EXACT []
synonym: "epstein-Barr virus receptor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001343
name: CD69 molecule
def: "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." []
synonym: "activation inducer molecule" EXACT []
synonym: "AIM" EXACT []
synonym: "BL-AC/P26" EXACT []
synonym: "C-type lectin domain family 2 member C" EXACT []
synonym: "CD69" EXACT []
synonym: "CLEC2C" RELATED []
synonym: "EA1" EXACT []
synonym: "early activation antigen CD69" EXACT []
synonym: "early T-cell activation antigen p60" EXACT []
synonym: "GP32/28" EXACT []
synonym: "leukocyte surface antigen Leu-23" EXACT []
synonym: "MLR-3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001344
name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3
def: "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." []
synonym: "CD203c" EXACT []
synonym: "E-NPP 3" EXACT []
synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" EXACT []
synonym: "ENPP3" EXACT []
synonym: "PD-Ibeta" EXACT []
synonym: "PDNP3" RELATED []
synonym: "phosphodiesterase I beta" EXACT []
synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001345
name: endoglin
def: "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." []
synonym: "CD105" EXACT []
synonym: "cell surface MJ7/18 antigen" EXACT []
synonym: "Edg" RELATED []
synonym: "END" RELATED []
synonym: "ENG" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001350
name: forkhead box protein P3
def: "A protein that is a translation product of the human FOXP3 gene or a 1:1 ortholog thereof." []
synonym: "FOXP3" EXACT []
synonym: "IPEX" RELATED []
synonym: "scurfin" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001352
name: glycophorin
def: "A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001355
name: immunoglobulin gamma Fc receptor II/III/IV
def: "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001356
name: immunoglobulin gamma Fc receptor I
def: "A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in human." []
synonym: "Fc-gamma receptor" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001380
name: interleukin-2 receptor subunit alpha
def: "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." []
synonym: "CD25" EXACT []
synonym: "IL-2 receptor subunit alpha" EXACT []
synonym: "IL-2-RA" EXACT []
synonym: "IL-2R subunit alpha" EXACT []
synonym: "IL2-RA" EXACT []
synonym: "Il2r" RELATED []
synonym: "IL2RA" EXACT []
synonym: "p55" BROAD []
synonym: "TAC antigen" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001381
name: interleukin-2 receptor subunit beta
def: "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." []
synonym: "CD122" EXACT []
synonym: "high affinity IL-2 receptor subunit beta" EXACT []
synonym: "IL-2 receptor subunit beta" EXACT []
synonym: "IL-2R subunit beta" EXACT []
synonym: "IL-2RB" EXACT []
synonym: "IL2RB" EXACT []
synonym: "p70-75" EXACT []
synonym: "p75" BROAD []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001398
name: leukocyte immunoglobulin-like receptor subfamily A member 4
def: "A leukocyte immunoglobulin-like receptor subfamily member that is a translation product of the human LILRA4 gene or a 1:1 ortholog thereof. This gene is a member of a lineage-specific gene expansion in primates." []
synonym: "CD85 antigen-like family member G" EXACT []
synonym: "CD85g" EXACT []
synonym: "ILT-7" EXACT []
synonym: "ILT7" RELATED []
synonym: "immunoglobulin-like transcript 7" EXACT []
synonym: "LILRA4" EXACT []
is_a: PR:000044780 ! leukocyte immunoglobulin-like receptor subfamily member

[Term]
id: PR:000001402
name: killer cell lectin-like receptor subfamily D member 1
def: "A protein that is a translation product of the human KLRD1 gene or a 1:1 ortholog thereof." []
synonym: "CD94" EXACT []
synonym: "KLRD1" EXACT []
synonym: "KP43" EXACT []
synonym: "natural killer cells antigen CD94" EXACT []
synonym: "NK cell receptor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001403
name: tetraspanin
def: "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001408
name: ADP-ribosyl cyclase 1
def: "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." []
synonym: "cADPr hydrolase 1" EXACT []
synonym: "CD38" EXACT []
synonym: "cyclic ADP-ribose hydrolase 1" EXACT []
synonym: "I-19" EXACT []
synonym: "NIM-R5 antigen" EXACT []
synonym: "T10" EXACT []
is_a: PR:000001281 ! ADP-ribosyl cyclase

[Term]
id: PR:000001412
name: CD86 molecule
def: "A B7-related protein that is a translation product of the human CD86 gene or a 1:1 ortholog thereof." []
synonym: "activation B7-2 antigen" EXACT []
synonym: "B70" EXACT []
synonym: "BU63" EXACT []
synonym: "CD28LG2" RELATED []
synonym: "CD86" EXACT []
synonym: "CD86 antigen" EXACT []
synonym: "CTLA-4 counter-receptor B7.2" EXACT []
synonym: "early T-cell costimulatory molecule 1" EXACT []
synonym: "ETC-1" EXACT []
synonym: "FUN-1" EXACT []
synonym: "T-lymphocyte activation antigen CD86" EXACT []
is_a: PR:000001290 ! B7-related protein

[Term]
id: PR:000001431
name: N-formyl peptide receptor
def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the FPR1, FPR2, or FPR3 gene and whose active form binds N-formyl methionyl peptides." []
is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor

[Term]
id: PR:000001438
name: CD80 molecule
def: "A B7-related protein that is a translation product of the human CD80 gene or a 1:1 ortholog thereof." []
synonym: "activation B7-1 antigen" EXACT []
synonym: "B7" EXACT []
synonym: "BB1" EXACT []
synonym: "CD28LG" RELATED []
synonym: "CD28LG1" RELATED []
synonym: "CD80" EXACT []
synonym: "CTLA-4 counter-receptor B7.1" EXACT []
synonym: "LAB7" RELATED []
synonym: "T-lymphocyte activation antigen CD80" EXACT []
is_a: PR:000001290 ! B7-related protein

[Term]
id: PR:000001444
name: cadherin-5
def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." []
synonym: "7B4 antigen" EXACT []
synonym: "CD144" EXACT []
synonym: "CDH5" EXACT []
synonym: "vascular endothelial cadherin" EXACT []
synonym: "VE-cadherin" EXACT []
is_a: PR:000001327 ! cadherin

[Term]
id: PR:000001447
name: cadherin-1
def: "A cadherin that is a translation product of the human CDH1 gene or a 1:1 ortholog thereof." []
synonym: "ARC-1" EXACT []
synonym: "CAM 120/80" EXACT []
synonym: "CD324" EXACT []
synonym: "CDH1" EXACT []
synonym: "CDHE" RELATED []
synonym: "E-cadherin" EXACT []
synonym: "epithelial cadherin" EXACT []
synonym: "UVO" RELATED []
synonym: "uvomorulin" EXACT []
is_a: PR:000001327 ! cadherin

[Term]
id: PR:000001456
name: alpha-(1,3)-fucosyltransferase FUT4
def: "An alpha-(1,3)-fucosyltransferase that is a translation product of the human FUT4 gene or a 1:1 ortholog thereof." []
synonym: "CD15" EXACT []
synonym: "ELAM-1 ligand fucosyltransferase" EXACT []
synonym: "ELFT" RELATED []
synonym: "FCT3A" RELATED []
synonym: "Fuc-TIV" EXACT []
synonym: "fucosyltransferase 4" EXACT []
synonym: "fucosyltransferase FUT4" EXACT []
synonym: "fucosyltransferase IV" EXACT []
synonym: "FucT-IV" EXACT []
synonym: "FUT4" EXACT []
synonym: "galactoside 3-L-fucosyltransferase" BROAD []
is_a: PR:000001320 ! alpha-(1,3)-fucosyltransferase

[Term]
id: PR:000001460
name: glycophorin-A
def: "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." []
synonym: "CD235a" EXACT []
synonym: "GPA" RELATED []
synonym: "GYPA" EXACT []
synonym: "MN sialoglycoprotein" EXACT []
synonym: "PAS-2" EXACT []
synonym: "sialoglycoprotein alpha" EXACT []
is_a: PR:000001352 ! glycophorin

[Term]
id: PR:000001465
name: high affinity immunoglobulin gamma Fc receptor I
def: "An immunoglobulin gamma Fc receptor I that is a translation product of the human FCGR1A gene or a 1:1 ortholog thereof." []
synonym: "CD64" EXACT []
synonym: "Fc-gamma RI" EXACT []
synonym: "FCG1" RELATED []
synonym: "FCGR1" RELATED []
synonym: "FCGR1A" EXACT []
synonym: "FcRI" EXACT []
synonym: "IGFR1" RELATED []
synonym: "IgG Fc receptor I" EXACT []
is_a: PR:000001356 ! immunoglobulin gamma Fc receptor I

[Term]
id: PR:000001479
name: low affinity immunoglobulin gamma Fc region receptor II
def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." []
synonym: "CD32" BROAD []
synonym: "Fc gamma receptor IIB" EXACT []
synonym: "Fc-gamma RII" EXACT []
synonym: "Fc-gamma-RIIB" EXACT []
synonym: "Fcgr2" EXACT []
synonym: "Fcgr2b" RELATED []
synonym: "FcRII" EXACT []
synonym: "IgG Fc receptor II beta" EXACT []
synonym: "ly-17" EXACT []
synonym: "lymphocyte antigen 17" EXACT []
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV

[Term]
id: PR:000001481
name: low affinity immunoglobulin gamma Fc region receptor II-b
def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." []
synonym: "CD32" BROAD []
synonym: "CDw32" BROAD []
synonym: "Fc-gamma RII-b" EXACT []
synonym: "Fc-gamma-RIIb" EXACT []
synonym: "FCG2" RELATED []
synonym: "FCGR2B" EXACT []
synonym: "FcRII-b" EXACT []
synonym: "IGFR2" RELATED []
synonym: "IgG Fc receptor II-b" EXACT []
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV

[Term]
id: PR:000001483
name: low affinity immunoglobulin gamma Fc region receptor III
def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." []
synonym: "CD16" EXACT []
synonym: "Fc-gamma RIII" EXACT []
synonym: "Fcgr3" EXACT []
synonym: "FcRIII" EXACT []
synonym: "IgG Fc receptor III" EXACT []
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV

[Term]
id: PR:000001580
name: fMet-Leu-Phe receptor
def: "An N-formyl peptide receptor that is a translation product of the human FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions." []
synonym: "fMLP receptor" EXACT []
synonym: "FPR" EXACT []
synonym: "FPR1" EXACT []
synonym: "N-formyl peptide receptor" BROAD []
synonym: "N-formylpeptide chemoattractant receptor" EXACT []
is_a: PR:000001431 ! N-formyl peptide receptor

[Term]
id: PR:000001753
name: transcription factor NF-kappa-B subunit
def: "A protein with a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region." []
synonym: "transcription factor NF-kappa-B" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001785
name: prominin
def: "A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001786
name: prominin-1
def: "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." []
synonym: "antigen AC133" EXACT []
synonym: "antigen AC133 homolog" EXACT []
synonym: "CD133" EXACT []
synonym: "Prom" RELATED []
synonym: "PROM1" EXACT []
synonym: "prominin-like protein 1" EXACT []
synonym: "PROML1" RELATED []
is_a: PR:000001785 ! prominin

[Term]
id: PR:000001800
name: 5'-nucleotidase
def: "A protein that is a translation product of the human NT5E gene or a 1:1 ortholog thereof." []
synonym: "5'-NT" EXACT []
synonym: "CD73" EXACT []
synonym: "ecto-5'-nucleotidase" EXACT []
synonym: "NT5" RELATED []
synonym: "NT5E" EXACT []
synonym: "NTE" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001806
name: C-type lectin domain family 6 member A
def: "A protein that is a translation product of the human CLEC6A gene or a 1:1 ortholog thereof." []
synonym: "C-type lectin superfamily member 10" EXACT []
synonym: "Clec4n" RELATED []
synonym: "CLEC6A" EXACT []
synonym: "CLECSF10" RELATED []
synonym: "DC-associated C-type lectin 2" EXACT []
synonym: "dectin-2" EXACT []
synonym: "DECTIN2" RELATED []
synonym: "dendritic cell-associated C-type lectin 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001807
name: C-type lectin domain family 7 member A
def: "A protein that is a translation product of the human CLEC7A gene or a 1:1 ortholog thereof." []
synonym: "beta-glucan receptor" EXACT []
synonym: "BGR" RELATED []
synonym: "C-type lectin superfamily member 12" EXACT []
synonym: "CLEC7A" EXACT []
synonym: "CLECSF12" RELATED []
synonym: "DC-associated C-type lectin 1" EXACT []
synonym: "dectin-1" EXACT []
synonym: "DECTIN1" RELATED []
synonym: "dendritic cell-associated C-type lectin 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001809
name: CD59-like glycoprotein
def: "A protein that is a translation product of the CD59 or closely related gene. This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001810
name: CSF-1/PDGF receptor-type tyrosine-protein kinase
def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001813
name: EGF-like module-containing mucin-like hormone receptor-like 1
def: "An adhesion G-protein coupled receptor that is a translation product of the human EMR1 gene or a 1:1 ortholog thereof." []
synonym: "cell surface glycoprotein F4/80" EXACT []
synonym: "EGF-like module receptor 1" EXACT []
synonym: "EMR1" EXACT []
synonym: "EMR1 hormone receptor" EXACT []
synonym: "Gpf480" RELATED []
synonym: "TM7LN3" RELATED []
is_a: PR:000001087 ! adhesion G-protein coupled receptor

[Term]
id: PR:000001820
name: MHC class II histocompatibility antigen alpha chain
def: "A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, an alpha domain (Pfam:PF00993) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seem between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001832
name: SIRP/SHPS-1 family protein
def: "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001833
name: SLAM family member 1
def: "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." []
synonym: "CD150" EXACT []
synonym: "CDw150" EXACT []
synonym: "IPO-3" EXACT []
synonym: "SLAM" RELATED []
synonym: "SLAMF1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001835
name: T-box transcription factor TBX21
def: "A protein that is a translation product of the human TBX21 gene or a 1:1 ortholog thereof." []
synonym: "T-box protein 21" EXACT []
synonym: "T-cell-specific T-box transcription factor T-bet" EXACT []
synonym: "TBET" RELATED []
synonym: "TBLYM" RELATED []
synonym: "TBX21" EXACT []
synonym: "transcription factor TBLYM" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001836
name: CD7 molecule
def: "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." []
synonym: "CD7" EXACT []
synonym: "GP40" EXACT []
synonym: "T-cell antigen CD7" EXACT []
synonym: "T-cell leukemia antigen" EXACT []
synonym: "T-cell surface antigen Leu-9" EXACT []
synonym: "TP41" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001838
name: T-cell surface glycoprotein CD1
def: "A protein with core architecture consisting of a signal sequence, an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a very short cytoplasmic region. Forms a heterodimer with beta-2 microglobulin." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001839
name: T-cell surface glycoprotein CD5
def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." []
synonym: "CD5" EXACT []
synonym: "LEU1" RELATED []
synonym: "ly-1" EXACT []
synonym: "lymphocyte antigen 1" EXACT []
synonym: "lymphocyte antigen T1/Leu-1" EXACT []
synonym: "Lyt-1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001841
name: T-cell-specific surface glycoprotein CD28
def: "A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." []
synonym: "CD28" EXACT []
synonym: "TP44" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001843
name: Thy-1 membrane glycoprotein
def: "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." []
synonym: "CD90" EXACT []
synonym: "CDw90" EXACT []
synonym: "Thy-1" RELATED []
synonym: "Thy-1 antigen" EXACT []
synonym: "THY1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001844
name: arginase-1
def: "A protein that is a translation product of the human ARG1 gene or a 1:1 ortholog thereof." []
synonym: "ARG1" EXACT []
synonym: "liver-type arginase" EXACT []
synonym: "type I arginase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001850
name: cathepsin K
def: "A cathepsin-like protease that is a translation product of the human CTSK gene or a 1:1 ortholog thereof." []
synonym: "cathepsin O" RELATED []
synonym: "cathepsin O2" EXACT []
synonym: "cathepsin X" RELATED []
synonym: "CTSK" EXACT []
synonym: "CTSO" RELATED []
synonym: "CTSO2" RELATED []
is_a: PR:000040662 ! cathepsin-like protease

[Term]
id: PR:000001852
name: cytotoxic T-lymphocyte protein 4
def: "A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof." []
synonym: "CD152" EXACT []
synonym: "CTLA-4" EXACT []
synonym: "CTLA4" EXACT []
synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001858
name: immunoglobulin iota chain
def: "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." []
synonym: "CD179 antigen-like family member A" EXACT []
synonym: "CD179a" EXACT []
synonym: "protein VPreB1" EXACT []
synonym: "V(pre)B protein" EXACT []
synonym: "VPREB" RELATED []
synonym: "VpreB protein" EXACT []
synonym: "VPREB1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001859
name: immunoglobulin lambda-like polypeptide 1
def: "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." []
synonym: "CD179 antigen-like family member B" EXACT []
synonym: "CD179b" EXACT []
synonym: "Ig lambda-5" EXACT []
synonym: "Igl-5" RELATED []
synonym: "IGL1" RELATED []
synonym: "IGLL1" EXACT []
synonym: "immunoglobulin omega polypeptide" EXACT []
synonym: "immunoglobulin-related protein 14.1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001860
name: inducible T-cell costimulator
def: "A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof." []
synonym: "activation-inducible lymphocyte immunomediatory molecule" EXACT []
synonym: "AILIM" RELATED []
synonym: "CCLP" EXACT []
synonym: "CD278" EXACT []
synonym: "CD28 and CTLA-4-like protein" EXACT []
synonym: "CD28-related protein 1" EXACT []
synonym: "CRP-1" RELATED []
synonym: "ICOS" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001861
name: integrin beta
def: "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001865
name: interleukin-3 receptor class 2 alpha chain
def: "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." []
synonym: "CD123" EXACT []
synonym: "IL-3 receptor subunit alpha" EXACT []
synonym: "IL-3R subunit alpha" EXACT []
synonym: "IL-3R-alpha" EXACT []
synonym: "IL-3RA" EXACT []
synonym: "IL3R" RELATED []
synonym: "IL3RA" EXACT []
synonym: "interleukin-3 receptor class II alpha chain" EXACT []
synonym: "Sut-1" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001867
name: interleukin-5 receptor subunit alpha
def: "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." []
synonym: "CD125" EXACT []
synonym: "CDw125" EXACT []
synonym: "IL-5 receptor subunit alpha" EXACT []
synonym: "IL-5R subunit alpha" EXACT []
synonym: "IL-5R-alpha" EXACT []
synonym: "IL-5RA" EXACT []
synonym: "IL5R" RELATED []
synonym: "IL5RA" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001869
name: interleukin-7 receptor subunit alpha
def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." []
synonym: "CD127" EXACT []
synonym: "CDw127" EXACT []
synonym: "IL-7 receptor subunit alpha" EXACT []
synonym: "IL-7R subunit alpha" EXACT []
synonym: "IL-7R-alpha" EXACT []
synonym: "IL-7RA" EXACT []
synonym: "IL7R" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001874
name: KLRB1-like protein
def: "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001879
name: leukosialin
def: "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." []
synonym: "B-cell differentiation antigen LP-3" EXACT []
synonym: "CD43" EXACT []
synonym: "galactoglycoprotein" EXACT []
synonym: "GALGP" EXACT []
synonym: "leukocyte sialoglycoprotein" EXACT []
synonym: "ly-48" EXACT []
synonym: "lymphocyte antigen 48" EXACT []
synonym: "sialophorin" EXACT []
synonym: "SPN" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001880
name: low affinity immunoglobulin epsilon Fc receptor
def: "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." []
synonym: "BLAST-2" EXACT []
synonym: "C-type lectin domain family 4 member J" EXACT []
synonym: "CD23" EXACT []
synonym: "CD23A" RELATED []
synonym: "CLEC4J" RELATED []
synonym: "Fc-epsilon-RII" EXACT []
synonym: "FCE2" RELATED []
synonym: "FCER2" EXACT []
synonym: "Fcer2a" RELATED []
synonym: "IGEBF" RELATED []
synonym: "immunoglobulin E-binding factor" EXACT []
synonym: "lymphocyte IgE receptor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001883
name: lysosome-associated membrane protein
def: "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001884
name: macrophage receptor MARCO
def: "A protein that is a translation product of the human MARCO gene or a 1:1 ortholog thereof." []
synonym: "macrophage receptor with collagenous structure" EXACT []
synonym: "MARCO" EXACT []
synonym: "SCARA2" RELATED []
synonym: "scavenger receptor class A member 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001885
name: macrophage scavenger receptor types I and II
def: "A protein that is a translation product of the human MSR1 gene or a 1:1 ortholog thereof." []
synonym: "CD204" EXACT []
synonym: "macrophage acetylated LDL receptor I and II" EXACT []
synonym: "MSR1" EXACT []
synonym: "SCARA1" RELATED []
synonym: "scavenger receptor class A member 1" EXACT []
synonym: "scavenger receptor type A" EXACT []
synonym: "Scvr" RELATED []
synonym: "SR-A" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001888
name: membrane alanyl aminopeptidase-like metallopeptidase
def: "A protein with core architecture consisting of a Peptidase family M1 domain (Pfam:PF01433)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001889
name: CD14 molecule
def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." []
synonym: "CD14" EXACT []
synonym: "monocyte differentiation antigen CD14" EXACT []
synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001892
name: CD33 molecule
def: "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." []
synonym: "CD33" EXACT []
synonym: "gp67" EXACT []
synonym: "myeloid cell surface antigen CD33" EXACT []
synonym: "sialic acid-binding Ig-like lectin 3" EXACT []
synonym: "siglec-3" EXACT []
synonym: "SIGLEC3" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001893
name: natural cytotoxicity triggering receptor 1
def: "A protein that is a translation product of the human NCR1 gene or a 1:1 ortholog thereof." []
synonym: "activating receptor 1" EXACT []
synonym: "CD335" EXACT []
synonym: "LY94" RELATED []
synonym: "lymphocyte antigen 94" EXACT []
synonym: "lymphocyte antigen 94 homolog" EXACT []
synonym: "mAR-1" EXACT []
synonym: "natural killer cell p46-related protein" EXACT []
synonym: "NCR1" EXACT []
synonym: "NK cell-activating receptor" BROAD []
synonym: "NK-p46" EXACT []
synonym: "NKp46" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001896
name: natural killer cell receptor 2B4
def: "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." []
synonym: "2B4" RELATED []
synonym: "CD244" EXACT []
synonym: "NAIL" EXACT []
synonym: "NK cell activation-inducing ligand" EXACT []
synonym: "NK cell type I receptor protein 2B4" EXACT []
synonym: "NKR2B4" EXACT []
synonym: "Nmrk" RELATED []
synonym: "non-MHC restricted killing associated" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001897
name: natural killer cell receptor NKG2
def: "A protein with core architecture consisting of an as yet unnamed domain in the amino-terminal half and a carboxyl-terminal Lectin C-type domain (Pfam:PF00059)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001898
name: neprilysin
def: "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." []
synonym: "atriopeptidase" EXACT []
synonym: "CALLA" EXACT []
synonym: "CD10" EXACT []
synonym: "common acute lymphocytic leukemia antigen" EXACT []
synonym: "enkephalinase" EXACT []
synonym: "EPN" RELATED []
synonym: "MME" EXACT []
synonym: "NEP" EXACT []
synonym: "neutral endopeptidase" EXACT []
synonym: "neutral endopeptidase 24.11" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001902
name: nuclear receptor ROR-gamma
def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." []
synonym: "NR1F3" RELATED []
synonym: "nuclear receptor RZR-gamma" EXACT []
synonym: "nuclear receptor subfamily 1 group F member 3" EXACT []
synonym: "retinoid-related orphan receptor-gamma" EXACT []
synonym: "RORC" EXACT []
synonym: "RORG" RELATED []
synonym: "RZRG" RELATED []
synonym: "Thor" RELATED []
synonym: "thymus orphan receptor" EXACT []
synonym: "TOR" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001903
name: paired box protein PAX-5
def: "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." []
synonym: "B-cell-specific transcription factor" EXACT []
synonym: "BSAP" EXACT []
synonym: "Pax-5" RELATED []
synonym: "PAX5" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001905
name: platelet glycoprotein 4
def: "A protein that is a translation product of the human CD36 gene or a 1:1 ortholog thereof." []
synonym: "CD36" EXACT []
synonym: "FAT" EXACT []
synonym: "fatty acid translocase" EXACT []
synonym: "glycoprotein IIIb" EXACT []
synonym: "GP3B" RELATED []
synonym: "GP4" RELATED []
synonym: "GPIIIB" EXACT []
synonym: "GPIV" EXACT []
synonym: "leukocyte differentiation antigen CD36" EXACT []
synonym: "PAS IV" EXACT []
synonym: "PAS-4" EXACT []
synonym: "platelet collagen receptor" EXACT []
synonym: "platelet glycoprotein IV" EXACT []
synonym: "thrombospondin receptor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001907
name: platelet glycoprotein Ib alpha chain
def: "A protein that is a translation product of the human GP1BA gene or a 1:1 ortholog thereof." []
synonym: "antigen CD42b-alpha" EXACT []
synonym: "CD42b" EXACT []
synonym: "glycoprotein Ibalpha" EXACT []
synonym: "GP-Ib alpha" EXACT []
synonym: "GP1BA" EXACT []
synonym: "GPIb-alpha" EXACT []
synonym: "GPIbA" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001919
name: programmed cell death protein 1
def: "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." []
synonym: "CD279" EXACT []
synonym: "PD-1" EXACT []
synonym: "PD1" RELATED []
synonym: "PDCD1" EXACT []
synonym: "protein PD-1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001925
name: scavenger receptor cysteine-rich type 1 protein M130
def: "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." []
synonym: "CD163" EXACT []
synonym: "hemoglobin scavenger receptor" EXACT []
synonym: "M130" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001927
name: sialic acid-binding Ig-like lectin 5
def: "A protein that is a translation product of the human SIGLEC5 gene or a 1:1 ortholog thereof." []
synonym: "CD170" EXACT []
synonym: "CD33 antigen-like 2" EXACT []
synonym: "CD33L2" RELATED []
synonym: "mSiglec-F" EXACT []
synonym: "OB-binding protein 2" EXACT []
synonym: "OB-BP2" EXACT []
synonym: "OBBP2" RELATED []
synonym: "obesity-binding protein 2" EXACT []
synonym: "sialic acid-binding Ig-like lectin F" EXACT []
synonym: "siglec-5" EXACT []
synonym: "siglec-F" EXACT []
synonym: "SIGLEC5" EXACT []
synonym: "Siglecf" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001931
name: sialoadhesin
def: "A protein that is a translation product of the human SIGLEC1 gene or a 1:1 ortholog thereof." []
synonym: "CD169" EXACT []
synonym: "Sa" RELATED []
synonym: "SER" EXACT []
synonym: "sheep erythrocyte receptor" EXACT []
synonym: "sialic acid-binding Ig-like lectin 1" EXACT []
synonym: "siglec-1" EXACT []
synonym: "SIGLEC1" EXACT []
synonym: "SN" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001932
name: signal transducer CD24
def: "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." []
synonym: "CD24" EXACT []
synonym: "CD24A" RELATED []
synonym: "HSA" EXACT []
synonym: "ly-52" EXACT []
synonym: "lymphocyte antigen 52" EXACT []
synonym: "M1/69-J11D heat stable antigen" EXACT []
synonym: "nectadrin" EXACT []
synonym: "R13-Ag" EXACT []
synonym: "small cell lung carcinoma cluster 4 antigen" EXACT []
synonym: "X62 heat stable antigen" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001935
name: syndecan-1
def: "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." []
synonym: "CD138" EXACT []
synonym: "SDC" RELATED []
synonym: "SDC1" EXACT []
synonym: "Synd-1" RELATED []
synonym: "SYND1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001937
name: tartrate-resistant acid phosphatase type 5
def: "A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof." []
synonym: "ACP5" EXACT []
synonym: "T5ap" RELATED []
synonym: "tartrate-resistant acid ATPase" EXACT []
synonym: "TR-AP" EXACT []
synonym: "Trap" RELATED []
synonym: "TrATPase" EXACT []
synonym: "type 5 acid phosphatase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001938
name: thrombomodulin-like receptor
def: "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001941
name: trans-acting T-cell-specific transcription factor GATA-3
def: "A protein that is a translation product of the human GATA3 gene or a 1:1 ortholog thereof." []
synonym: "Gata-3" RELATED []
synonym: "GATA-binding factor 3" EXACT []
synonym: "GATA3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001944
name: transcription factor PU.1
def: "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." []
synonym: "31 kDa-transforming protein" EXACT []
synonym: "SFFV proviral integration 1 protein" EXACT []
synonym: "Sfpi-1" RELATED []
synonym: "Sfpi1" RELATED []
synonym: "SPI1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001945
name: transferrin receptor protein 1
def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." []
synonym: "CD71" EXACT []
synonym: "p90" BROAD []
synonym: "T9" EXACT []
synonym: "TfR" EXACT []
synonym: "TfR1" EXACT []
synonym: "TFRC" EXACT []
synonym: "TR" RELATED []
synonym: "Trfr" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001950
name: tumor necrosis factor ligand superfamily member 5
def: "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." []
synonym: "CD154" EXACT []
synonym: "CD40-L" EXACT []
synonym: "CD40L" RELATED []
synonym: "CD40LG" EXACT []
synonym: "T-cell antigen Gp39" EXACT []
synonym: "TNF-related activation protein" EXACT []
synonym: "TNFSF5" RELATED []
synonym: "TRAP" BROAD []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001954
name: tumor necrosis factor receptor superfamily member 11A
def: "A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof." []
synonym: "CD265" EXACT []
synonym: "ODFR" EXACT []
synonym: "osteoclast differentiation factor receptor" EXACT []
synonym: "RANK" RELATED []
synonym: "receptor activator of NF-KB" EXACT []
synonym: "TNFRSF11A" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001963
name: CD27 molecule
def: "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." []
synonym: "CD27" EXACT []
synonym: "CD27L receptor" EXACT []
synonym: "T-cell activation antigen CD27" EXACT []
synonym: "T14" EXACT []
synonym: "TNFRSF7" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001968
name: tyrosine-protein phosphatase non-receptor type substrate 1
def: "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." []
synonym: "Bit" EXACT []
synonym: "brain Ig-like molecule with tyrosine-based activation motifs" EXACT []
synonym: "CD172 antigen-like family member A" EXACT []
synonym: "CD172a" EXACT []
synonym: "inhibitory receptor SHPS-1" EXACT []
synonym: "macrophage fusion receptor" EXACT []
synonym: "MFR" RELATED []
synonym: "mSIRP-alpha1" EXACT []
synonym: "MyD-1 antigen" EXACT []
synonym: "MYD1" RELATED []
synonym: "p84" BROAD []
synonym: "PTPNS1" RELATED []
synonym: "SHP substrate 1" EXACT []
synonym: "SHPS-1" EXACT []
synonym: "SHPS1" RELATED []
synonym: "signal-regulatory protein alpha-1" EXACT []
synonym: "signal-regulatory protein alpha-2" EXACT []
synonym: "signal-regulatory protein alpha-3" EXACT []
synonym: "SIRP" RELATED []
synonym: "Sirp-alpha-1" EXACT []
synonym: "Sirp-alpha-2" EXACT []
synonym: "Sirp-alpha-3" EXACT []
synonym: "SIRPA" EXACT []
is_a: PR:000001832 ! SIRP/SHPS-1 family protein

[Term]
id: PR:000001969
name: urokinase plasminogen activator surface receptor
def: "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." []
synonym: "CD87" EXACT []
synonym: "MO3" RELATED []
synonym: "monocyte activation antigen Mo3" EXACT []
synonym: "PLAUR" EXACT []
synonym: "U-PAR" EXACT []
synonym: "uPAR" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000001971
name: vascular endothelial growth factor receptor
def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000002001
name: receptor-type tyrosine-protein kinase FLT3
def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." []
synonym: "CD135" EXACT []
synonym: "fetal liver kinase 2" EXACT []
synonym: "FLK-2" EXACT []
synonym: "FLT-3" EXACT []
synonym: "FLT3" EXACT []
synonym: "Fms-like tyrosine kinase 3" EXACT []
synonym: "stem cell tyrosine kinase 1" EXACT []
synonym: "STK-1" RELATED []
synonym: "STK1" RELATED []
synonym: "tyrosine-protein kinase FLT3" EXACT []
synonym: "tyrosine-protein kinase receptor flk-2" EXACT []
synonym: "tyrosine-protein kinase receptor FLT3" EXACT []
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase

[Term]
id: PR:000002015
name: MHC class II histocompatibility antigen alpha chain HLA-DRA
def: "An MHC class II histocompatibility antigen alpha chain that is a translation product of the human HLA-DRA gene or a 1:1 ortholog thereof." []
synonym: "H2-Ea" RELATED []
synonym: "H2-IE-alpha" EXACT []
synonym: "HLA-DRA" EXACT []
synonym: "HLA-DRA1" RELATED []
synonym: "MHC class II antigen DRA" EXACT []
is_a: PR:000001820 ! MHC class II histocompatibility antigen alpha chain

[Term]
id: PR:000002023
name: NKG2-A/NKG2-B type II integral membrane protein
def: "A natural killer cell receptor NKG2 that is a translation product of the human KLRC1 gene or a 1:1 ortholog thereof." []
synonym: "CD159 antigen-like family member A" EXACT []
synonym: "CD159a" EXACT []
synonym: "KLRC1" EXACT []
synonym: "NK cell receptor A" EXACT []
synonym: "NKG2-A/B-activating NK receptor" EXACT []
synonym: "NKG2A" RELATED []
is_a: PR:000001897 ! natural killer cell receptor NKG2

[Term]
id: PR:000002025
name: T-cell surface glycoprotein CD1a
def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1A gene or a 1:1 ortholog thereof." []
synonym: "CD1A" EXACT []
synonym: "CD1a" EXACT []
synonym: "hTa1 thymocyte antigen" EXACT []
synonym: "T-cell surface antigen T6/Leu-6" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1

[Term]
id: PR:000002027
name: T-cell surface glycoprotein CD1c
def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1C gene or a 1:1 ortholog thereof." []
synonym: "CD1C" EXACT []
synonym: "CD1c" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1

[Term]
id: PR:000002028
name: antigen-presenting glycoprotein CD1d
def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1D gene or a 1:1 ortholog thereof." []
synonym: "Cd1.1" RELATED []
synonym: "CD1D" EXACT []
synonym: "CD1d" EXACT []
synonym: "CD1d.1" EXACT []
synonym: "Cd1d1" RELATED []
synonym: "R3G1" EXACT []
synonym: "T-cell surface glycoprotein CD1d" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1

[Term]
id: PR:000002031
name: aminopeptidase N
def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ANPEP gene or a 1:1 ortholog thereof." []
synonym: "alanyl aminopeptidase" EXACT []
synonym: "aminopeptidase M" EXACT []
synonym: "ANPEP" EXACT []
synonym: "AP-M" EXACT []
synonym: "AP-N" EXACT []
synonym: "APN" RELATED []
synonym: "CD13" EXACT []
synonym: "gp150" EXACT []
synonym: "Lap-1" RELATED []
synonym: "Lap1" RELATED []
synonym: "membrane protein p161" EXACT []
synonym: "microsomal aminopeptidase" EXACT []
synonym: "myeloid plasma membrane glycoprotein CD13" EXACT []
synonym: "PEPN" RELATED []
is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase

[Term]
id: PR:000002037
name: complement component C1q receptor
def: "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." []
synonym: "Aa4" RELATED []
synonym: "C1q/MBL/SPA receptor" EXACT []
synonym: "C1qR" EXACT []
synonym: "C1qR(p)" EXACT []
synonym: "C1QR1" RELATED []
synonym: "C1qRp" EXACT []
synonym: "CD93" EXACT []
synonym: "CDw93" EXACT []
synonym: "cell surface antigen AA4" EXACT []
synonym: "complement component 1 q subcomponent receptor 1" EXACT []
synonym: "ly-68" EXACT []
synonym: "Ly68" RELATED []
synonym: "lymphocyte antigen 68" EXACT []
synonym: "matrix-remodeling-associated protein 4" EXACT []
synonym: "MXRA4" RELATED []
is_a: PR:000001938 ! thrombomodulin-like receptor

[Term]
id: PR:000002039
name: glutamyl aminopeptidase
def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." []
synonym: "aminopeptidase A" EXACT []
synonym: "AP-A" EXACT []
synonym: "BP-1/6C3 antigen" EXACT []
synonym: "CD249" EXACT []
synonym: "differentiation antigen gp160" EXACT []
synonym: "EAP" RELATED []
synonym: "ENPEP" EXACT []
is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase

[Term]
id: PR:000002062
name: macrophage colony-stimulating factor 1 receptor
def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." []
synonym: "CD115" EXACT []
synonym: "CSF-1-R" EXACT []
synonym: "CSF1R" EXACT []
synonym: "Csfmr" RELATED []
synonym: "FMS" RELATED []
synonym: "proto-oncogene c-Fms" EXACT []
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase

[Term]
id: PR:000002064
name: macrosialin
def: "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." []
synonym: "CD68" EXACT []
synonym: "gp110" RELATED []
is_a: PR:000001883 ! lysosome-associated membrane protein

[Term]
id: PR:000002065
name: mast/stem cell growth factor receptor
def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." []
synonym: "CD117" EXACT []
synonym: "KIT" EXACT []
synonym: "proto-oncogene c-Kit" EXACT []
synonym: "SCFR" EXACT []
synonym: "Sl" RELATED []
synonym: "tyrosine-protein kinase Kit" EXACT []
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase

[Term]
id: PR:000002105
name: thrombomodulin
def: "A thrombomodulin-like receptor that is a translation product of the human THBD gene or a 1:1 ortholog thereof." []
synonym: "BDCA-3" EXACT []
synonym: "BDCA3" EXACT []
synonym: "CD141" EXACT []
synonym: "fetomodulin" EXACT []
synonym: "THBD" EXACT []
synonym: "THRM" RELATED []
synonym: "TM" EXACT []
is_a: PR:000001938 ! thrombomodulin-like receptor

[Term]
id: PR:000002112
name: vascular endothelial growth factor receptor 2
def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." []
synonym: "CD309" EXACT []
synonym: "fetal liver kinase 1" EXACT []
synonym: "FLK-1" EXACT []
synonym: "FLK1" RELATED []
synonym: "KDR" EXACT []
synonym: "kinase insert domain receptor" EXACT []
synonym: "kinase NYK" EXACT []
synonym: "protein-tyrosine kinase receptor flk-1" EXACT []
synonym: "VEGFR-2" EXACT []
is_a: PR:000001971 ! vascular endothelial growth factor receptor

[Term]
id: PR:000002972
name: macrophage mannose receptor 1
def: "A C-type lectin with multiple lectin domains that is a translation product of the human MRC1 gene or a 1:1 ortholog thereof." []
synonym: "C-type lectin domain family 13 member D" EXACT []
synonym: "C-type lectin domain family 13 member D-like" RELATED []
synonym: "CD206" EXACT []
synonym: "CLEC13D" RELATED []
synonym: "CLEC13DL" RELATED []
synonym: "macrophage mannose receptor 1-like protein 1" RELATED []
synonym: "MMR" EXACT []
synonym: "MRC1" EXACT []
synonym: "MRC1L1" RELATED []
is_a: PR:000001025 ! C-type lectin with multiple lectin domains

[Term]
id: PR:000002976
name: ly-6-like protein
def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000002977
name: killer cell lectin-like receptor subfamily B member 1C
def: "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." []
synonym: "CD161 antigen-like family member C" EXACT []
synonym: "CD161c" EXACT []
synonym: "Klrb1c" EXACT []
synonym: "ly-55c" EXACT []
synonym: "Ly55c" RELATED []
synonym: "lymphocyte antigen 55c" EXACT []
synonym: "natural killer cell surface protein P1-40" EXACT []
synonym: "NK1.1" EXACT []
synonym: "NKR-P1 40" EXACT []
synonym: "NKR-P1.9" EXACT []
synonym: "NKR-P1C" EXACT []
synonym: "Nkrp1c" RELATED []
is_a: PR:000001874 ! KLRB1-like protein

[Term]
id: PR:000002978
name: lymphocyte antigen 6G
def: "A ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." []
synonym: "ly-6G" EXACT []
synonym: "ly-6G.1" EXACT []
synonym: "Ly6g" EXACT []
is_a: PR:000002976 ! ly-6-like protein

[Term]
id: PR:000002979
name: lymphocyte antigen 6A-2/6E-1
def: "A ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." []
synonym: "ly-6A.2/Ly-6E.1" EXACT []
synonym: "Ly6" RELATED []
synonym: "Ly6a" EXACT []
synonym: "SCA-1" RELATED []
synonym: "stem cell antigen 1" EXACT []
synonym: "T-cell-activating protein" EXACT []
synonym: "TAP" RELATED []
is_a: PR:000002976 ! ly-6-like protein

[Term]
id: PR:000002980
name: lymphocyte antigen 6C2
def: "A ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." []
synonym: "ly-6C2" EXACT []
synonym: "Ly6c" RELATED []
synonym: "Ly6c2" EXACT []
is_a: PR:000002976 ! ly-6-like protein

[Term]
id: PR:000002981
name: lymphocyte antigen 76
def: "A protein that is a translation product of the mouse Ly76 gene or a 1:1 ortholog thereof." []
synonym: "Ly76" EXACT []
synonym: "ter-119" EXACT []
synonym: "ter119" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003450
name: B-cell lymphoma 6 protein
def: "A protein that is a translation product of the human BCL6 gene or a 1:1 ortholog thereof." []
synonym: "B-cell lymphoma 5 protein" EXACT []
synonym: "BCL-5" EXACT []
synonym: "BCL-6" EXACT []
synonym: "BCL5" RELATED []
synonym: "BCL6" EXACT []
synonym: "LAZ3" RELATED []
synonym: "protein LAZ-3" EXACT []
synonym: "ZBTB27" RELATED []
synonym: "zinc finger and BTB domain-containing protein 27" EXACT []
synonym: "zinc finger protein 51" EXACT []
synonym: "ZNF51" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003455
name: nuclear receptor ROR-gamma isoform 2
def: "A nuclear receptor ROR-gamma that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P51450-2 or a 1:1 ortholog thereof." []
synonym: "RORC/iso:2" EXACT []
is_a: PR:000001902 ! nuclear receptor ROR-gamma

[Term]
id: PR:000003457
name: V(D)J recombination-activating protein 1
def: "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." []
synonym: "RAG-1" EXACT []
synonym: "RAG1" EXACT []
synonym: "RING finger protein 74" EXACT []
synonym: "RNF74" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003460
name: V(D)J recombination-activating protein 2
def: "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." []
synonym: "RAG-2" EXACT []
synonym: "RAG2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003463
name: eomesodermin
def: "A T-brain transcription factor that is a translation product of the human EOMES gene or a 1:1 ortholog thereof." []
synonym: "EOMES" EXACT []
synonym: "T-box brain protein 2" EXACT []
synonym: "T-brain-2" EXACT []
synonym: "TBR-2" EXACT []
synonym: "TBR2" RELATED []
is_a: PR:000003506 ! T-brain transcription factor

[Term]
id: PR:000003466
name: perforin-1
def: "A protein that is a translation product of the human PRF1 gene or a 1:1 ortholog thereof." []
synonym: "cytolysin" EXACT []
synonym: "lymphocyte pore-forming protein" EXACT []
synonym: "P1" RELATED []
synonym: "PFP" EXACT []
synonym: "PRF1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003469
name: early growth response protein 2
def: "A protein that is a translation product of the human EGR2 gene or a 1:1 ortholog thereof." []
synonym: "AT591" EXACT []
synonym: "EGR-2" EXACT []
synonym: "EGR2" EXACT []
synonym: "Krox-20" RELATED []
synonym: "KROX20" RELATED []
synonym: "Zfp-25" RELATED []
synonym: "zinc finger protein Krox-20" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003499
name: granzyme B
def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof." []
synonym: "C11" EXACT []
synonym: "cathepsin G-like 1" EXACT []
synonym: "CGL1" RELATED []
synonym: "CSPB" RELATED []
synonym: "CTLA-1" BROAD []
synonym: "CTLA1" RELATED []
synonym: "CTSGL1" EXACT []
synonym: "cytotoxic T-lymphocyte proteinase 2" EXACT []
synonym: "fragmentin-2" BROAD []
synonym: "granzyme-2" EXACT []
synonym: "GRB" RELATED []
synonym: "GZMB" EXACT []
synonym: "HLP" RELATED []
synonym: "human lymphocyte protein" EXACT []
synonym: "lymphocyte protease" EXACT []
synonym: "SECT" EXACT []
synonym: "T-cell serine protease 1-3E" EXACT []
is_a: PR:000003505 ! leukocyte granule-associated proteinase

[Term]
id: PR:000003505
name: leukocyte granule-associated proteinase
def: "A protein that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003506
name: T-brain transcription factor
def: "A protein that contains one copy of the T-box domain (Pfam:PF00907) and it is involved in the anterior neural specification." []
synonym: "Eomes/Tbr1/Tbx21 family protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000003516
name: lactosylceramide 4-alpha-galactosyltransferase
def: "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." []
synonym: "A14GALT" RELATED []
synonym: "A4GALT" EXACT []
synonym: "A4GALT1" RELATED []
synonym: "alpha-1,4-galactosyltransferase" EXACT []
synonym: "alpha-1,4-N-acetylglucosaminyltransferase" BROAD []
synonym: "alpha4Gal-T1" EXACT []
synonym: "CD77 synthase" EXACT []
synonym: "Gb3 synthase" EXACT []
synonym: "globotriaosylceramide synthase" EXACT []
synonym: "P1/Pk synthase" EXACT []
synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000005178
name: CD9 molecule
def: "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." []
synonym: "5H9 antigen" EXACT []
synonym: "CD9" EXACT []
synonym: "CD9 antigen" EXACT []
synonym: "cell growth-inhibiting gene 2 protein" EXACT []
synonym: "leukocyte antigen MIC3" EXACT []
synonym: "MIC3" RELATED []
synonym: "motility-related protein" EXACT []
synonym: "MRP-1" EXACT []
synonym: "p24" BROAD []
synonym: "tetraspanin-29" EXACT []
synonym: "tspan-29" EXACT []
synonym: "TSPAN29" RELATED []
is_a: PR:000001403 ! tetraspanin

[Term]
id: PR:000005307
name: CCAAT/enhancer-binding protein alpha
def: "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." []
synonym: "C/EBP alpha" EXACT []
synonym: "CEBPA" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000005310
name: CCAAT/enhancer-binding protein epsilon
def: "A protein that is a translation product of the human CEBPE gene or a 1:1 ortholog thereof." []
synonym: "C/EBP epsilon" EXACT []
synonym: "CEBPE" EXACT []
synonym: "Gm294" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000006169
name: cell surface glycoprotein CD200 receptor 3
def: "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." []
synonym: "CD200 cell surface glycoprotein receptor-like 3" EXACT []
synonym: "CD200 cell surface glycoprotein receptor-like b" EXACT []
synonym: "CD200 receptor-like 3" EXACT []
synonym: "Cd200r3" EXACT []
synonym: "CD200RLb" EXACT []
synonym: "cell surface glycoprotein OX2 receptor 3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000006172
name: CD209 molecule-like protein B
def: "A protein that is a translation product of the mouse Cd209b gene or a 1:1 ortholog thereof." []
synonym: "Cd209b" EXACT []
synonym: "DC-SIGN-related protein 1" EXACT []
synonym: "DC-SIGNR1" EXACT []
synonym: "OtB7" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000006611
name: DNA nucleotidylexotransferase
def: "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." []
synonym: "DNTT" EXACT []
synonym: "TDT" EXACT []
synonym: "terminal addition enzyme" EXACT []
synonym: "terminal deoxynucleotidyltransferase" EXACT []
synonym: "terminal transferase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000007152
name: eosinophil peroxidase
def: "A protein that is a translation product of the human EPX gene or a 1:1 ortholog thereof." []
synonym: "EPER" RELATED []
synonym: "EPO" BROAD []
synonym: "EPP" RELATED []
synonym: "EPX" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000007431
name: high affinity immunoglobulin epsilon receptor subunit alpha
def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." []
synonym: "Fc-epsilon RI-alpha" EXACT []
synonym: "FCE1A" RELATED []
synonym: "FCER1A" EXACT []
synonym: "FcERI" RELATED []
synonym: "IgE Fc receptor subunit alpha" EXACT []
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV

[Term]
id: PR:000007597
name: proto-oncogene c-Fos
def: "A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof." []
synonym: "cellular oncogene fos" EXACT []
synonym: "FOS" EXACT []
synonym: "G0/G1 switch regulatory protein 7" EXACT []
synonym: "G0S7" RELATED []
synonym: "proto-oncogene protein c-fos" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000007857
name: erythroid transcription factor
def: "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." []
synonym: "Eryf1" EXACT []
synonym: "GATA-1" EXACT []
synonym: "GATA-binding factor 1" EXACT []
synonym: "GATA1" EXACT []
synonym: "GF-1" RELATED []
synonym: "GF1" RELATED []
synonym: "NF-E1 DNA-binding protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000007858
name: endothelial transcription factor GATA-2
def: "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." []
synonym: "GATA-binding protein 2" EXACT []
synonym: "GATA2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000007939
name: glial fibrillary acidic protein
def: "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." []
synonym: "GFAP" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000008467
name: hemoglobin subunit zeta
def: "A protein that is a translation product of the human HBZ gene or a 1:1 ortholog thereof." []
synonym: "alpha-like embryonic globin chain x" EXACT []
synonym: "Hba-x" RELATED []
synonym: "HBAZ" EXACT []
synonym: "HBZ" EXACT []
synonym: "Hbz1" RELATED []
synonym: "HBZ2" RELATED []
synonym: "hemoglobin zeta chain" EXACT []
synonym: "zeta-globin" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000008857
name: hemoglobin subunit beta-1
def: "A protein that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof." []
synonym: "beta-1-globin" EXACT []
synonym: "Hbb-b1" EXACT []
synonym: "hemoglobin beta-1 chain" EXACT []
synonym: "hemoglobin beta-major chain" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000008982
name: interleukin-17 receptor B
def: "A protein that is a translation product of the human IL17RB gene or a 1:1 ortholog thereof." []
synonym: "CRL4" RELATED []
synonym: "cytokine receptor-like 4" EXACT []
synonym: "EVI27" RELATED []
synonym: "IL-17 receptor B" EXACT []
synonym: "IL-17 receptor homolog 1" EXACT []
synonym: "IL-17B receptor" EXACT []
synonym: "IL-17ER" EXACT []
synonym: "IL-17RB" EXACT []
synonym: "IL-17Rh1" EXACT []
synonym: "IL17BR" RELATED []
synonym: "IL17RB" EXACT []
synonym: "IL17Rh1" EXACT []
synonym: "interleukin-17B receptor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000008994
name: interleukin-1 receptor-like 1
def: "A protein that is a translation product of the human IL1RL1 gene or a 1:1 ortholog thereof." []
synonym: "DER4" RELATED []
synonym: "IL1RL1" EXACT []
synonym: "Ly84" RELATED []
synonym: "lymphocyte antigen 84" EXACT []
synonym: "protein ST2" EXACT []
synonym: "protein T1" EXACT []
synonym: "ST2" RELATED []
synonym: "Ste2" RELATED []
synonym: "T1" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009127
name: integrin alpha-IIb
def: "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." []
synonym: "CD41" EXACT []
synonym: "GP2B" RELATED []
synonym: "GPalpha IIb" EXACT []
synonym: "GPIIb" EXACT []
synonym: "ITGA2B" EXACT []
synonym: "ITGAB" RELATED []
synonym: "platelet membrane glycoprotein IIb" EXACT []
is_a: PR:000025797 ! integrin alpha lacking A domain

[Term]
id: PR:000009129
name: integrin alpha-4
def: "An integrin alpha lacking A domain that is a translation product of the human ITGA4 gene or a 1:1 ortholog thereof." []
synonym: "CD49 antigen-like family member D" EXACT []
synonym: "CD49d" EXACT []
synonym: "integrin alpha-IV" EXACT []
synonym: "ITGA4" EXACT []
synonym: "LPAM subunit alpha" EXACT []
synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha" EXACT []
synonym: "VLA-4 subunit alpha" EXACT []
is_a: PR:000025797 ! integrin alpha lacking A domain

[Term]
id: PR:000009143
name: integrin beta-7
def: "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." []
synonym: "Gut homing receptor beta subunit" EXACT []
synonym: "integrin beta-P" EXACT []
synonym: "ITGB7" EXACT []
synonym: "M290 IEL antigen" EXACT []
is_a: PR:000001861 ! integrin beta

[Term]
id: PR:000009616
name: T-cell surface glycoprotein YE1/48
def: "A protein that is a translation product of the mouse Klra1 gene or a 1:1 ortholog thereof." []
synonym: "Klra1" EXACT []
synonym: "Ly-49" RELATED []
synonym: "ly-49a" EXACT []
synonym: "Ly49" RELATED []
synonym: "Ly49A" RELATED []
synonym: "lymphocyte antigen 49a" EXACT []
synonym: "T lymphocyte antigen A1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009618
name: killer cell lectin-like receptor 3
def: "A protein that is a translation product of the mouse Klra3 gene or a 1:1 ortholog thereof." []
synonym: "5E6" EXACT []
synonym: "Klra3" EXACT []
synonym: "ly-49c" EXACT []
synonym: "Ly49C" RELATED []
synonym: "lymphocyte antigen 49c" EXACT []
synonym: "T-cell surface glycoprotein Ly-49C" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009619
name: killer cell lectin-like receptor 4
def: "A protein that is a translation product of the mouse Klra4 gene or a 1:1 ortholog thereof." []
synonym: "Klra4" EXACT []
synonym: "ly-49d" EXACT []
synonym: "Ly49-d" RELATED []
synonym: "Ly49d" RELATED []
synonym: "lymphocyte antigen 49d" EXACT []
synonym: "T-cell surface glycoprotein Ly-49D" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009623
name: killer cell lectin-like receptor 8
def: "A protein that is a translation product of the mouse Klra8 gene or a 1:1 ortholog thereof." []
synonym: "Klra8" EXACT []
synonym: "ly-49h" EXACT []
synonym: "Ly49-h" RELATED []
synonym: "Ly49H" RELATED []
synonym: "lymphocyte antigen 49h" EXACT []
synonym: "T-cell surface glycoprotein Ly-49H" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009725
name: neutrophil gelatinase-associated lipocalin
def: "A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof." []
synonym: "25 kDa alpha-2-microglobulin-related subunit of MMP-9" EXACT []
synonym: "HNL" RELATED []
synonym: "LCN2" EXACT []
synonym: "lipocalin-2" EXACT []
synonym: "NGAL" EXACT []
synonym: "oncogene 24p3" EXACT []
synonym: "p25" BROAD []
synonym: "SV-40-induced 24P3 protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009766
name: galectin-1
def: "A protein that is a translation product of the human LGALS1 gene or a 1:1 ortholog thereof." []
synonym: "14 kDa laminin-binding protein" EXACT []
synonym: "14 kDa lectin" EXACT []
synonym: "beta-galactoside-binding lectin L-14-I" EXACT []
synonym: "gal-1" EXACT []
synonym: "galaptin" EXACT []
synonym: "Gbp" RELATED []
synonym: "HBL" EXACT []
synonym: "HLBP14" EXACT []
synonym: "HPL" EXACT []
synonym: "lactose-binding lectin 1" EXACT []
synonym: "lectin galactoside-binding soluble 1" EXACT []
synonym: "LGALS1" EXACT []
synonym: "putative MAPK-activating protein PM12" EXACT []
synonym: "S-Lac lectin 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000009978
name: lactotransferrin
def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." []
synonym: "lactoferrin" EXACT []
synonym: "LF" RELATED []
synonym: "LTF" EXACT []
synonym: "talalactoferrin" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000010329
name: tyrosine-protein kinase Mer
def: "A protein that is a translation product of the human MERTK gene or a 1:1 ortholog thereof." []
synonym: "MER" RELATED []
synonym: "MERTK" EXACT []
synonym: "proto-oncogene c-Mer" EXACT []
synonym: "proto-oncogene tyrosine-protein kinase MER" EXACT []
synonym: "receptor tyrosine kinase MerTK" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000010543
name: myeloperoxidase
def: "A protein that is a translation product of the human MPO gene or a 1:1 ortholog thereof." []
synonym: "MPO" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000010799
name: myb proto-oncogene protein
def: "A protein that is a translation product of the human MYB gene or a 1:1 ortholog thereof." []
synonym: "MYB" EXACT []
synonym: "proto-oncogene c-Myb" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000011178
name: nuclear factor NF-kappa-B p100 subunit
def: "A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof." []
synonym: "DNA-binding factor KBF2" EXACT []
synonym: "H2TF1" EXACT []
synonym: "lymphocyte translocation chromosome 10 protein" EXACT []
synonym: "lyt10" EXACT []
synonym: "NFKB2" EXACT []
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT []
synonym: "oncogene Lyt-10" EXACT []
is_a: PR:000001753 ! transcription factor NF-kappa-B subunit

[Term]
id: PR:000014046
name: non-secretory ribonuclease
def: "A protein that is a translation product of the human RNASE2 gene or a 1:1 ortholog thereof." []
synonym: "Ear4" RELATED []
synonym: "EDN" RELATED []
synonym: "eosinophil cationic-type ribonuclease 4" EXACT []
synonym: "eosinophil-derived neurotoxin" EXACT []
synonym: "MR-4" EXACT []
synonym: "ribonuclease 2" EXACT []
synonym: "ribonuclease US" EXACT []
synonym: "RNase 2" EXACT []
synonym: "RNase UpI-2" EXACT []
synonym: "RNASE2" EXACT []
synonym: "RNS2" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000014047
name: eosinophil cationic protein
def: "A protein that is a translation product of the human RNASE3 gene or a 1:1 ortholog thereof." []
synonym: "ECP" EXACT []
synonym: "ribonuclease 3" RELATED []
synonym: "RNase 3" EXACT []
synonym: "RNASE3" EXACT []
synonym: "RNS3" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000014362
name: runt-related transcription factor 1
def: "A protein that is a translation product of the human RUNX1 gene or a 1:1 ortholog thereof." []
synonym: "acute myeloid leukemia 1 protein" EXACT []
synonym: "AML1" RELATED []
synonym: "CBF-alpha-2" EXACT []
synonym: "CBFA2" RELATED []
synonym: "core-binding factor subunit alpha-2" EXACT []
synonym: "oncogene AML-1" EXACT []
synonym: "PEA2-alpha B" EXACT []
synonym: "PEBP2-alpha B" EXACT []
synonym: "Pebp2ab" RELATED []
synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit" EXACT []
synonym: "RUNX1" EXACT []
synonym: "SL3-3 enhancer factor 1 alpha B subunit" EXACT []
synonym: "SL3/AKV core-binding factor alpha B subunit" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000016043
name: T-cell acute lymphocytic leukemia protein 1
def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." []
synonym: "bHLHa17" EXACT []
synonym: "class A basic helix-loop-helix protein 17" EXACT []
synonym: "SCL" RELATED []
synonym: "stem cell protein" EXACT []
synonym: "T-cell leukemia/lymphoma protein 5" EXACT []
synonym: "TAL-1" EXACT []
synonym: "TAL1" EXACT []
synonym: "TCL5" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:000016401
name: transmembrane emp24 domain-containing protein 1
def: "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." []
synonym: "IL1RL1L" RELATED []
synonym: "IL1RL1LG" RELATED []
synonym: "interleukin-1 receptor-like 1 ligand" EXACT []
synonym: "putative T1/ST2 receptor-binding protein" EXACT []
synonym: "TMED1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000018263
name: amino acid chain
def: "An organic amino compound that is a polymer of amino acid chain components (unmodified amino-acid residues and/or modified amino-acid residues linked by peptide bonds or derivatives of such bonds." []
synonym: "peptide" NARROW []
synonym: "polypeptide" NARROW []

[Term]
id: PR:000021082
name: bone marrow proteoglycan proteolytic cleavage product
def: "A proteolytic cleavage product that is derived from bone marrow proteoglycan." []
synonym: "PRG2/ClvPrd" EXACT []

[Term]
id: PR:000022006
name: eosinophil granule major basic protein
def: "A bone marrow proteoglycan proteolytic cleavage product that derives from bone marrow proteoglycan isoform 1, signal peptide removed form that has had the acidic propeptide removed." []
is_a: PR:000021082 ! bone marrow proteoglycan proteolytic cleavage product

[Term]
id: PR:000025402
name: T cell receptor co-receptor CD8
def: "A protein complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." []
synonym: "CD8alphabeta" EXACT []
synonym: "TCR co-receptor CD8" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: PR:000025403
name: T-cell surface glycoprotein CD8 alpha chain isoform 1
def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." []
synonym: "CD8A/iso:1" EXACT []
synonym: "mCD8alpha" EXACT []
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: PR:000025796
name: integrin alpha
def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." []
is_a: PR:000000001 ! protein

[Term]
id: PR:000025797
name: integrin alpha lacking A domain
def: "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." []
is_a: PR:000025796 ! integrin alpha

[Term]
id: PR:000030035
name: G-protein coupled receptor
synonym: "fam:GPCR" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000040662
name: cathepsin-like protease
def: "A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus." []
synonym: "cathepsin" NARROW []
synonym: "fam:CTS" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000044780
name: leukocyte immunoglobulin-like receptor subfamily member
synonym: "fam:LILR" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: UBERON:0000002
name: uterine cervix
def: "Lower, narrow portion of the uterus where it joins with the top end of the vagina." []
synonym: "canalis cervicis uteri" EXACT []
synonym: "caudal segment of uterus" EXACT []
synonym: "cervical canal" RELATED []
synonym: "cervical canal of uterus" EXACT []
synonym: "cervix" BROAD []
synonym: "cervix of uterus" RELATED []
synonym: "cervix uteri" EXACT []
synonym: "neck of uterus" EXACT []
synonym: "uterine cervix" EXACT []
is_a: UBERON:0001560 ! neck of organ
is_a: UBERON:0005156 ! reproductive structure
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0000004
name: nose
def: "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity." []
synonym: "nasal sac" EXACT []
synonym: "nasus" RELATED []
synonym: "nose" EXACT []
synonym: "olfactory apparatus" RELATED []
synonym: "peripheral olfactory organ" EXACT []
synonym: "proboscis" RELATED []
is_a: UBERON:0002268 ! olfactory organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0003050 ! olfactory placode
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0000006
name: islet of Langerhans
def: "the clusters of hormone-producing cells that are scattered throughout the pancreas" []
synonym: "island of Langerhans" RELATED []
synonym: "island of pancreas" RELATED []
synonym: "islets of langerhans" RELATED []
synonym: "pancreatic insula" EXACT []
synonym: "pancreatic islet" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0034922 ! cell cluster
relationship: part_of UBERON:0000016 ! endocrine pancreas

[Term]
id: UBERON:0000007
name: pituitary gland
def: "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." []
synonym: "glandula pituitaria" EXACT []
synonym: "Hp" BROAD []
synonym: "hypophysis" RELATED []
synonym: "hypophysis cerebri" RELATED []
synonym: "pituitary" EXACT []
synonym: "pituitary body" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0003296 ! gland of diencephalon
is_a: UBERON:0010133 ! neuroendocrine gland
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0002196 ! adenohypophysis
relationship: has_part UBERON:0002198 ! neurohypophysis
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0000009
name: submucosa
def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." []
synonym: "organ submucosa" EXACT []
synonym: "region of submucosa" EXACT []
synonym: "submucosa of organ" EXACT []
synonym: "submucosa of region of organ" EXACT []
synonym: "submucous layer" RELATED []
synonym: "tela submucosa" RELATED []
synonym: "tunica submucosa" RELATED []
is_a: UBERON:0004923 ! organ component layer

[Term]
id: UBERON:0000010
name: peripheral nervous system
def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." []
synonym: "lateral part of the basal amygdalar nucleus" RELATED []
synonym: "lateral part of the basolateral nucleus" RELATED []
synonym: "nucleus amygdalae basalis, pars lateralis" RELATED []
synonym: "nucleus amygdaloideus basalis, pars lateralis magnocellularis" RELATED []
synonym: "nucleus basalis lateralis amygdalae" RELATED []
synonym: "pars peripherica" EXACT []
synonym: "pars peripherica; systema nervosum periphericum" RELATED []
synonym: "PNS" RELATED []
synonym: "systema nervosum periphericum" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000012
name: somatic nervous system
def: "Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors." []
synonym: "PNS - somatic" EXACT []
synonym: "somatic nervous system, somatic division" EXACT []
synonym: "somatic peripheral nervous system" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0000014
name: zone of skin
def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." []
synonym: "portion of skin" EXACT []
synonym: "region of skin" EXACT []
synonym: "skin" EXACT []
synonym: "skin region" EXACT []
synonym: "skin zone" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0034944 ! zone of organ
relationship: has_part UBERON:0001003 ! skin epidermis
relationship: has_part UBERON:0002067 ! dermis
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: UBERON:0000015
name: anatomical boundary
def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." []
is_a: UBERON:0000466 ! immaterial anatomical entity

[Term]
id: UBERON:0000016
name: endocrine pancreas
def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." []
synonym: "endocrine pancreas" EXACT []
synonym: "endocrine part of pancreas" RELATED []
synonym: "islets of Langerhans part of pancreas" RELATED []
synonym: "pars endocrina pancreatis" EXACT []
is_a: UBERON:0000471 ! compound organ component
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: develops_from UBERON:0003923 ! dorsal pancreatic bud
relationship: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0000017
name: exocrine pancreas
def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." []
synonym: "exocrine component of pancreas" RELATED []
synonym: "exocrine pancreas" EXACT []
synonym: "exocrine part of pancreas" RELATED []
synonym: "pars exocrina pancreatis" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000409 ! serous gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005177 ! trunk region element
relationship: develops_from UBERON:0003924 ! ventral pancreatic bud
relationship: has_part UBERON:0001263 ! pancreatic acinus
relationship: has_part UBERON:0007329 ! pancreatic duct
relationship: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0000018
name: compound eye
def: "A light sensing organ composed of ommatidia" []
synonym: "adult compound eye" RELATED []
synonym: "faceted eye" RELATED []
synonym: "Facettenauge" RELATED []
synonym: "insect eye" RELATED []
synonym: "Komplexauge" RELATED []
synonym: "zusammengesetztes Auge" RELATED []
is_a: UBERON:0015165 ! multi-unit eye

[Term]
id: UBERON:0000019
name: camera-type eye
def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." []
synonym: "camera-type eye plus associated structures" RELATED []
synonym: "eye" BROAD []
synonym: "eyes" RELATED []
synonym: "orbital part of face" RELATED []
synonym: "orbital region" RELATED []
synonym: "regio orbitalis" EXACT []
synonym: "vertebrate eye" NARROW []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000047 ! simple eye
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0003072 ! optic cup
relationship: has_part UBERON:0000965 ! lens of camera-type eye
relationship: has_part UBERON:0000966 ! retina
relationship: part_of UBERON:0004088 ! orbital region

[Term]
id: UBERON:0000020
name: sense organ
def: "An organ that is capable of transducing sensory stimulus to the nervous system." []
synonym: "organ of sense organ system" EXACT []
synonym: "organ of sensory organ system" EXACT []
synonym: "organ of sensory system" EXACT []
synonym: "sense organ system organ" EXACT []
synonym: "sensillum" NARROW []
synonym: "sensor" RELATED []
synonym: "sensory organ" EXACT []
synonym: "sensory organ system organ" EXACT []
synonym: "sensory system organ" EXACT []
synonym: "Sinnesorgan" RELATED []
is_a: UBERON:0000062 ! organ
relationship: part_of UBERON:0001032 ! sensory system

[Term]
id: UBERON:0000021
name: cutaneous appendage
def: "Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales." []
synonym: "epidermal appendage" NARROW []
synonym: "epidermal growth" RELATED []
synonym: "skin appendage" EXACT []
is_a: UBERON:0013703 ! integumentary projection
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0000025
name: tube
def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." []
synonym: "anatomical tube" EXACT []
synonym: "duct" NARROW []
is_a: UBERON:0004111 ! anatomical conduit
relationship: has_part UBERON:0013522 ! subdivision of tube

[Term]
id: UBERON:0000026
name: appendage
def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." []
synonym: "appendages" RELATED []
synonym: "extremitaet" RELATED []
synonym: "extremity" RELATED []
synonym: "limbs/digits/tail" RELATED []
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0000029
name: lymph node
def: "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." []
synonym: "lymph gland" RELATED []
synonym: "nodus lymphaticus" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0005057 ! immune organ
relationship: has_part UBERON:0002006 ! cortex of lymph node
relationship: has_part UBERON:0002007 ! medulla of lymph node
relationship: has_part UBERON:0002194 ! capsule of lymph node
relationship: has_part UBERON:0002391 ! lymph
relationship: part_of UBERON:0002465 ! lymphoid system

[Term]
id: UBERON:0000030
name: lamina propria
def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." []
synonym: "lamina propria mucosa" EXACT []
synonym: "lamina propria mucosae" EXACT []
synonym: "tunica propria" RELATED []
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0000344 ! mucosa

[Term]
id: UBERON:0000031
name: lamina propria of trachea
def: "A lamina propria that is part of a respiratory airway." []
synonym: "lamina propria mucosa of trachea" EXACT []
synonym: "lamina propria mucosa of windpipe" EXACT []
synonym: "lamina propria mucosae of trachea" EXACT []
synonym: "lamina propria mucosae of windpipe" EXACT []
synonym: "lamina propria of windpipe" EXACT []
synonym: "trachea lamina propria" EXACT []
synonym: "trachea lamina propria mucosa" EXACT []
synonym: "trachea lamina propria mucosae" EXACT []
synonym: "tracheal lamina propria" EXACT []
synonym: "windpipe lamina propria" EXACT []
synonym: "windpipe lamina propria mucosa" EXACT []
synonym: "windpipe lamina propria mucosae" EXACT []
is_a: UBERON:0004779 ! respiratory system lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0001005 ! respiratory airway
relationship: part_of UBERON:0000379 ! tracheal mucosa
relationship: part_of UBERON:0001005 ! respiratory airway

[Term]
id: UBERON:0000033
name: head
def: "The head is the anterior-most division of the body [GO]." []
synonym: "adult head" NARROW []
synonym: "cephalic area" RELATED []
synonym: "head (volume)" EXACT []
is_a: UBERON:0011676 ! subdivision of organism along main body axis
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: part_of UBERON:0007811 ! craniocervical region

[Term]
id: UBERON:0000038
name: follicular fluid
def: "The fluid surrounding the ovum and granulosa cells in the ovarian follicle." []
synonym: "antral fluid, ovarian follicle" RELATED []
synonym: "liquor follicularis" EXACT []
synonym: "liquor folliculi" EXACT []
synonym: "liquor folliculi" RELATED []
synonym: "ovarian follicular fluid" RELATED []
synonym: "ovary follicle fluid" EXACT []
synonym: "ovary follicular fluid" RELATED []
is_a: UBERON:0000463 ! organism substance
relationship: part_of UBERON:0001305 ! ovarian follicle

[Term]
id: UBERON:0000042
name: serous membrane
def: "multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." []
synonym: "serosa" RELATED []
synonym: "tunica serosa" EXACT []
synonym: "wall of serous sac" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: has_part UBERON:0001136 ! mesothelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0000060 ! anatomical wall

[Term]
id: UBERON:0000043
name: tendon
def: "Dense regular connective tissue that connects muscle to bone[VSAO]." []
synonym: "sinew" RELATED []
synonym: "tendo" RELATED []
is_a: UBERON:0007846 ! dense regular connective tissue
relationship: part_of UBERON:0002204 ! musculoskeletal system

[Term]
id: UBERON:0000044
name: dorsal root ganglion
def: "* Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP)" []
synonym: "dorsal root ganglia" RELATED []
synonym: "dorsal root ganglion" EXACT []
synonym: "DRG" RELATED []
synonym: "ganglion of dorsal root" EXACT []
synonym: "ganglion sensorium nervi spinalis" RELATED []
synonym: "ganglion spinale" RELATED []
synonym: "ganglion spinalis" EXACT []
synonym: "posterior root ganglion" RELATED []
synonym: "spinal ganglion" EXACT []
synonym: "spinal ganglion part of peripheral nervous system" EXACT []
is_a: UBERON:0001800 ! sensory ganglion
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0003083 ! trunk neural crest

[Term]
id: UBERON:0000045
name: ganglion
def: "A biological tissue mass, most commonly a mass of nerve cell bodies." []
synonym: "ganglia" RELATED []
synonym: "neural ganglion" RELATED []
is_a: UBERON:0010001 ! cell cluster organ
disjoint_from: UBERON:0002420 ! basal ganglion
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000047
name: simple eye
def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." []
is_a: UBERON:0000970 ! eye

[Term]
id: UBERON:0000054
name: macula
def: "Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified]." []
synonym: "acoustic macula" RELATED []
synonym: "acoustic maculae" RELATED []
synonym: "macula" EXACT []
synonym: "maculae" EXACT []
synonym: "sensory macula" EXACT []
synonym: "sensory patch" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001846 ! internal ear

[Term]
id: UBERON:0000055
name: vessel
def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." []
is_a: UBERON:0004111 ! anatomical conduit

[Term]
id: UBERON:0000056
name: ureter
def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." []
synonym: "metanephric duct" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005179 ! pelvic region element
is_a: UBERON:0006555 ! excretory tube
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0005081 ! ureter ureteric bud
relationship: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0011143 ! upper urinary tract

[Term]
id: UBERON:0000057
name: urethra
def: "the fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening" []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0000164 ! primitive urogenital sinus
relationship: develops_from UBERON:0013241 ! embryonic urethral groove
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: UBERON:0000058
name: duct
def: "A tubular structure that transports secreted or excreted substances." []
synonym: "anatomical duct" EXACT []
synonym: "ducts" RELATED []
synonym: "exocrine duct" NARROW []
synonym: "exocrine gland duct" NARROW []
is_a: UBERON:0000063 ! organ subunit
relationship: has_part UBERON:0013686 ! anatomical conduit space
relationship: has_part UBERON:0034969 ! epithelial layer of duct

[Term]
id: UBERON:0000059
name: large intestine
def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." []
synonym: "intestinum crassum" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0013765 ! digestive system element
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0004907 ! lower digestive tract

[Term]
id: UBERON:0000060
name: anatomical wall
def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." []
synonym: "organ wall" RELATED []
synonym: "wall" BROAD []
synonym: "wall of organ" EXACT []
is_a: UBERON:0000064 ! organ part
relationship: has_part UBERON:0004923 ! organ component layer

[Term]
id: UBERON:0000061
name: anatomical structure
def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
synonym: "biological structure" EXACT []
synonym: "connected biological structure" EXACT []
is_a: UBERON:0000465 ! material anatomical entity

[Term]
id: UBERON:0000062
name: organ
def: "Anatomical structure that performs a specific function or group of functions [WP]." []
synonym: "anatomical unit" RELATED []
synonym: "body organ" RELATED []
synonym: "element" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0000467 ! anatomical system

[Term]
id: UBERON:0000063
name: organ subunit
def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." []
synonym: "organ region with fixed fiat boundary" RELATED []
synonym: "organ segment" RELATED []
synonym: "segment of organ" RELATED []
is_a: UBERON:0000064 ! organ part

[Term]
id: UBERON:0000064
name: organ part
def: "A multicellular structure that is a part of an organ." []
synonym: "cardinal organ part" EXACT []
synonym: "regional part of organ" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000062 ! organ

[Term]
id: UBERON:0000065
name: respiratory tract
def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts" []
is_a: UBERON:0001005 ! respiratory airway
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: develops_from UBERON:0007026 ! presumptive gut
relationship: develops_from UBERON:0008947 ! respiratory primordium
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0000072
name: proximo-distal subdivision of respiratory tract
def: "An section of a respiratory tract." []
synonym: "respiratory tract" RELATED []
synonym: "subdivision of respiratory tract" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0013522 ! subdivision of tube
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract

[Term]
id: UBERON:0000073
name: regional part of nervous system
def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." []
synonym: "part of nervous system" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000074
name: renal glomerulus
def: "A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]." []
synonym: "glomerular capillary tuft" RELATED []
synonym: "glomerular tuft" RELATED []
synonym: "glomerulus" BROAD []
synonym: "glomerulus renis" RELATED []
synonym: "malphigian glomerulus" RELATED []
synonym: "renal corpuscle" RELATED []
synonym: "renal glomeruli" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0005749 ! glomerular tuft
relationship: part_of UBERON:0001229 ! renal corpuscle

[Term]
id: UBERON:0000075
name: subdivision of skeletal system
def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." []
synonym: "skeletal system part" RELATED []
synonym: "skeletal system subdivision" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0000076
name: external ectoderm
def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." []
synonym: "surface (external) ectoderm" EXACT []
synonym: "surface ectoderm" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0000077
name: mixed endoderm/mesoderm-derived structure
def: "An anatomical structure that develops from the endoderm and the mesoderm." []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000925 ! endoderm
relationship: develops_from UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0000078
name: mixed ectoderm/mesoderm/endoderm-derived structure
def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: develops_from UBERON:0000925 ! endoderm
relationship: develops_from UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0000079
name: male reproductive system
def: "The organs associated with producing offspring in the gender that produces spermatozoa." []
synonym: "genitalia of male organism" EXACT []
synonym: "male genital organ" RELATED []
synonym: "male genital system" EXACT []
synonym: "male genital tract" RELATED []
synonym: "male genitalia" EXACT []
synonym: "male genitals" EXACT []
synonym: "male organism genitalia" EXACT []
synonym: "male organism reproductive system" EXACT []
synonym: "male reproductive tract" RELATED []
synonym: "reproductive system of male organism" EXACT []
synonym: "systema genitale masculinum" RELATED []
is_a: UBERON:0000990 ! reproductive system
intersection_of: UBERON:0000990 ! reproductive system
intersection_of: part_of UBERON:0003101 ! male organism
disjoint_from: UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0003101 ! male organism

[Term]
id: UBERON:0000080
name: mesonephros
def: "The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." []
synonym: "amphibian adult kidney" RELATED []
synonym: "corpus Wolffi" RELATED []
synonym: "mesonephric kidney" EXACT []
synonym: "mesonephroi" EXACT []
synonym: "middle kidney" RELATED []
synonym: "opisthonephros" RELATED []
synonym: "opisto nephros" RELATED []
synonym: "opistonephros" RELATED []
synonym: "Wolffian body" EXACT []
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0002120 ! pronephros

[Term]
id: UBERON:0000081
name: metanephros
def: "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]" []
synonym: "definite kidney" RELATED []
synonym: "definitive kidney" RELATED []
synonym: "hind kidney" RELATED []
synonym: "metanephric kidney" RELATED []
synonym: "metanephron" EXACT []
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: develops_from UBERON:0005080 ! metanephric ureteric bud
relationship: develops_from UBERON:0005753 ! caudal part of nephrogenic cord

[Term]
id: UBERON:0000083
name: mesonephric tubule
def: "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." []
synonym: "renal tubules" RELATED []
synonym: "tubuli mesonephrici" RELATED []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005103 ! mesonephric epithelium
is_a: UBERON:0006555 ! excretory tube
intersection_of: UBERON:0003914 ! epithelial tube
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0000084
name: ureteric bud
def: "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]" []
synonym: "diverticulum" RELATED []
synonym: "diverticulum metanephricum" RELATED []
synonym: "gemma ureterica" RELATED []
synonym: "metanephric bud" RELATED []
synonym: "metanephric diverticulum" RELATED []
synonym: "ureteric ampulla" RELATED []
synonym: "ureteric diverticulum" RELATED []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0034969 ! epithelial layer of duct
relationship: develops_from UBERON:0003074 ! mesonephric duct
relationship: part_of UBERON:0003074 ! mesonephric duct

[Term]
id: UBERON:0000085
name: morula
def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." []
synonym: "morula (2-16 cells)" RELATED []
is_a: UBERON:0000922 ! embryo
relationship: part_of UBERON:0004716 ! conceptus

[Term]
id: UBERON:0000087
name: inner cell mass
def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues" []
synonym: "early embryoblast" RELATED []
synonym: "embryoblast" RELATED []
synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED []
synonym: "ICM" RELATED []
synonym: "pluriblast" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000085 ! morula
relationship: develops_from UBERON:0000358 ! blastocyst
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0000088
name: trophoblast
def: "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta" []
synonym: "massa cellularis externa" RELATED []
synonym: "trophoblast layer" EXACT []
synonym: "trophoblastus" RELATED []
synonym: "trophoderm" RELATED []
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004345 ! trophectoderm
relationship: part_of UBERON:0000358 ! blastocyst

[Term]
id: UBERON:0000091
name: bilaminar disc
def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." []
synonym: "bilaminar disk" RELATED []
synonym: "bilaminary embryonic disc" EXACT []
synonym: "bilaminary germ disc" EXACT []
synonym: "embryonic disc" BROAD []
synonym: "embryonic shield" BROAD []
synonym: "germinal disc" BROAD []
synonym: "germinal disk" BROAD []
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000087 ! inner cell mass

[Term]
id: UBERON:0000094
name: membrane organ
def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]" []
synonym: "membrane" BROAD []
synonym: "membrane of organ" EXACT []
is_a: UBERON:0000062 ! organ

[Term]
id: UBERON:0000095
name: cardiac neural crest
def: "portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]" []
synonym: "cardiac neural crest complex" RELATED []
synonym: "complexus cristae neuralis cardiacus" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0002342 ! neural crest

[Term]
id: UBERON:0000102
name: lung vasculature
def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." []
synonym: "lung vascular network" EXACT []
synonym: "pulmonary vasculature" EXACT []
synonym: "vascular network of lung" EXACT []
synonym: "vasculature of lung" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0000114
name: lung connective tissue
def: "the connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin; it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" []
synonym: "connective tissue of lung" EXACT []
synonym: "lung interstitial tissue" RELATED []
synonym: "lung interstitium" RELATED []
synonym: "pulmonary connective tissue" RELATED []
synonym: "pulmonary interstitial tissue" RELATED []
synonym: "pulmonary interstitium" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003580 ! lower respiratory tract connective tissue
is_a: UBERON:0003837 ! thoracic segment connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0000115
name: lung epithelium
def: "The epithelial layer of the lung." []
synonym: "epithelial tissue of lung" EXACT []
synonym: "epithelium of lung" EXACT []
synonym: "lung epithelial tissue" EXACT []
synonym: "pulmonary epithelium" RELATED []
is_a: UBERON:0004815 ! lower respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002048 ! lung
relationship: develops_from UBERON:0001041 ! foregut
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0000117
name: respiratory tube
def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." []
synonym: "respiratory conducting tube" NARROW []
synonym: "segment of tracheobronchial tree" EXACT []
synonym: "segment of tracheobronchial tree" NARROW []
synonym: "tracheobronchial tree segment" NARROW []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000025 ! tube
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: has_part UBERON:0000483 ! epithelium
relationship: part_of UBERON:0000065 ! respiratory tract

[Term]
id: UBERON:0000118
name: lung bud
def: "Structure derived from foregut that becomes a lung[GO]." []
synonym: "gemma pulmonalis" RELATED []
synonym: "gemma respiratoria" RELATED []
synonym: "lung bud" RELATED []
synonym: "primary lung bud" RELATED []
synonym: "respiratory diverticulum" RELATED []
is_a: UBERON:0005153 ! epithelial bud
is_a: UBERON:0005911 ! endo-epithelium
relationship: develops_from UBERON:0005597 ! lung primordium
relationship: develops_from UBERON:0008947 ! respiratory primordium

[Term]
id: UBERON:0000119
name: cell layer
def: "Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium." []
synonym: "cell sheath" RELATED []
synonym: "layer" BROAD []
synonym: "layer of cells" EXACT []
synonym: "sheath of cells" RELATED []
is_a: UBERON:0000957 ! lamina

[Term]
id: UBERON:0000121
name: perineurium
def: "A layer of thin, concentrically arranged cells with interspersed collagen that lies within the epineurium. (Nolte, J., The Human Brain 3rd edition)" []
is_a: UBERON:0011822 ! dense irregular connective tissue
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000122
name: neuron projection bundle
def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." []
synonym: "funiculus" EXACT []
synonym: "nerve fiber bundle" EXACT []
synonym: "neural fiber bundle" EXACT []
is_a: UBERON:0005162 ! multi cell part structure
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000125
name: neural nucleus
def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)" []
synonym: "nervous system nucleus" EXACT []
synonym: "neuraxis nucleus" EXACT []
synonym: "neuronal nucleus" EXACT []
synonym: "nucleus" BROAD []
synonym: "nucleus of CNS" EXACT []
synonym: "nucleus of neuraxis" RELATED []
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0000153
name: anterior region of body
is_a: UBERON:0000475 ! organism subdivision
disjoint_from: UBERON:0000154 ! posterior region of body

[Term]
id: UBERON:0000154
name: posterior region of body
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0000158
name: membranous layer
synonym: "membrane" BROAD []
synonym: "membranous organ component" EXACT []
is_a: UBERON:0004923 ! organ component layer

[Term]
id: UBERON:0000159
name: anal canal
def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." []
synonym: "anal canal" EXACT []
synonym: "anal canal viewed anatomically" EXACT []
synonym: "anal pad" RELATED []
synonym: "anatomical anal canal" EXACT []
synonym: "anus" RELATED []
synonym: "canalis analis" RELATED []
synonym: "cloaca" RELATED []
synonym: "cloacal chamber" RELATED []
synonym: "mesenteron" RELATED []
synonym: "pars analis recti" RELATED []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0000160
name: intestine
def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." []
synonym: "bowel" EXACT []
synonym: "intestinal tract" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0000161
name: orifice
def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." []
synonym: "anatomical orifice" EXACT []
synonym: "anatomical ostium" BROAD []
synonym: "hilum" NARROW []
synonym: "ostium" BROAD []
is_a: UBERON:0004111 ! anatomical conduit

[Term]
id: UBERON:0000162
name: cloaca
def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures" []
synonym: "cloacal chamber" RELATED []
synonym: "vent" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013522 ! subdivision of tube
relationship: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0004122 ! genitourinary system

[Term]
id: UBERON:0000163
name: embryonic cloaca
def: "endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." []
synonym: "cloaca" RELATED []
is_a: UBERON:0000162 ! cloaca
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0012361 ! internal anal region

[Term]
id: UBERON:0000164
name: primitive urogenital sinus
def: "the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" []
synonym: "fetal UGS" EXACT []
synonym: "sinus urogenitalis" EXACT []
synonym: "UGS" EXACT []
synonym: "urogenital sinus" BROAD []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0000163 ! embryonic cloaca
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0000165
name: mouth
def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." []
synonym: "adult mouth" NARROW []
synonym: "cavital oralis" RELATED []
synonym: "cavitas oris" RELATED []
synonym: "cavum oris" RELATED []
synonym: "mouth cavity" RELATED []
synonym: "oral region" RELATED []
synonym: "oral vestibule" RELATED []
synonym: "regio oralis" EXACT []
synonym: "rima oris" RELATED []
synonym: "stoma" RELATED []
synonym: "stomatodaeum" RELATED []
synonym: "trophic apparatus" RELATED []
synonym: "vestibule of mouth" RELATED []
synonym: "vestibulum oris" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0035804 ! future mouth
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0000166
name: oral opening
def: "The orifice that connects the mouth to the exterior of the body." []
synonym: "mouth" RELATED []
synonym: "oral fissure" EXACT []
synonym: "oral orifice" EXACT []
synonym: "oral part of face" RELATED []
is_a: UBERON:0000161 ! orifice
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0000168
name: proximal-distal subdivision of colon
def: "A section dividing a colon along a proximal-distal axis." []
synonym: "segment of colon" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0000170
name: pair of lungs
def: "The pair of anatomical structures comprised of a left lung and right lung." []
synonym: "lungs" EXACT []
synonym: "lungs pair" EXACT []
synonym: "pulmones" EXACT []
synonym: "set of lungs" EXACT []
is_a: UBERON:0034925 ! anatomical collection
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0000171
name: respiration organ
def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." []
synonym: "apparatus respiratorius organ" EXACT []
synonym: "breathing organ" EXACT []
synonym: "gas exchange organ" RELATED []
synonym: "organ of apparatus respiratorius" EXACT []
synonym: "organ of respiratory system" EXACT []
synonym: "respiratory organ" EXACT []
synonym: "respiratory system organ" EXACT []
is_a: UBERON:0000062 ! organ
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0000173
name: amniotic fluid
def: "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." []
synonym: "acqua amnii" RELATED []
synonym: "liquor amnii" RELATED []
is_a: UBERON:0000463 ! organism substance

[Term]
id: UBERON:0000178
name: blood
def: "A fluid that is composed of blood plasma and erythrocytes." []
synonym: "portion of blood" EXACT []
synonym: "vertebrate blood" EXACT []
synonym: "whole blood" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: has_part UBERON:0001969 ! blood plasma
relationship: part_of UBERON:0002390 ! hematopoietic system
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0000179
name: haemolymphatic fluid
def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." []
synonym: "blood or blood analog" RELATED []
synonym: "circulating fluid" RELATED []
is_a: UBERON:0006314 ! bodily fluid
intersection_of: UBERON:0000463 ! organism substance
intersection_of: part_of UBERON:0002193 ! hemolymphoid system
relationship: part_of UBERON:0002193 ! hemolymphoid system

[Term]
id: UBERON:0000203
name: pallium
def: "Dorsal part (roof region) of the telencephalon[GO]." []
synonym: "area dorsalis telencephali" EXACT []
synonym: "dorsal part of telencephalon" EXACT []
synonym: "dorsal telencephalic area" EXACT []
synonym: "dorsal telencephalon" EXACT []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0000204
name: ventral part of telencephalon
def: "Dorsal part (base region) of the telencephalon." []
synonym: "area ventralis telencephali" EXACT []
synonym: "subpallium" EXACT []
synonym: "subpallium" NARROW []
synonym: "ventral telencephalon" EXACT []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0000211
name: ligament
def: "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." []
synonym: "ligament organ" EXACT []
is_a: UBERON:0000062 ! organ
relationship: has_part UBERON:0002384 ! connective tissue

[Term]
id: UBERON:0000305
name: amnion
def: "the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected" []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0005971 ! amniotic fold
relationship: has_part UBERON:0003254 ! amniotic ectoderm
relationship: has_part UBERON:0003262 ! amniotic mesoderm

[Term]
id: UBERON:0000307
name: blastula
def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." []
synonym: "blastosphere" RELATED []
synonym: "blastula embryo" EXACT []
is_a: UBERON:0000922 ! embryo
relationship: develops_from UBERON:0007010 ! cleaving embryo

[Term]
id: UBERON:0000310
name: breast
def: "The upper ventral region of an animal's torso." []
synonym: "mamma" RELATED []
synonym: "mammary part of chest" EXACT []
synonym: "mammary region" EXACT []
is_a: UBERON:0034929 ! external soft tissue zone
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0000314
name: cecum mucosa
def: "A mucosa that is part of a cecum [Automatically generated definition]." []
synonym: "caecum mucosa" EXACT []
synonym: "caecum mucosa of organ" EXACT []
synonym: "caecum mucous membrane" EXACT []
synonym: "caecum organ mucosa" EXACT []
synonym: "Cecal mucosa" EXACT []
synonym: "cecum mucosa of organ" EXACT []
synonym: "cecum mucous membrane" EXACT []
synonym: "cecum organ mucosa" EXACT []
synonym: "intestinum crassum caecum mucosa" EXACT []
synonym: "intestinum crassum caecum mucosa of organ" EXACT []
synonym: "intestinum crassum caecum mucous membrane" EXACT []
synonym: "intestinum crassum caecum organ mucosa" EXACT []
synonym: "mucosa of caecum" EXACT []
synonym: "mucosa of cecum" EXACT []
synonym: "mucosa of intestinum crassum caecum" EXACT []
synonym: "mucosa of organ of caecum" EXACT []
synonym: "mucosa of organ of cecum" EXACT []
synonym: "mucosa of organ of intestinum crassum caecum" EXACT []
synonym: "mucous membrane of caecum" EXACT []
synonym: "mucous membrane of cecum" EXACT []
synonym: "mucous membrane of intestinum crassum caecum" EXACT []
synonym: "organ mucosa of caecum" EXACT []
synonym: "organ mucosa of cecum" EXACT []
synonym: "organ mucosa of intestinum crassum caecum" EXACT []
is_a: UBERON:0000317 ! colonic mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0000317
name: colonic mucosa
def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." []
synonym: "colon mucosa" EXACT []
synonym: "colon mucous membrane" EXACT []
synonym: "colonic mucosa" EXACT []
synonym: "colonic mucous membrane" EXACT []
synonym: "large bowel mucosa" EXACT []
synonym: "mucosa of colon" EXACT []
synonym: "mucosa of large bowel" EXACT []
is_a: UBERON:0001207 ! mucosa of large intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0000320
name: duodenal mucosa
def: "A mucosa that is part of a duodenum [Automatically generated definition]." []
synonym: "Doudenal mucosa" EXACT []
synonym: "Duodenal mucous membrane" EXACT []
synonym: "duodenum mucosa" RELATED []
synonym: "mucosa of duodenum" EXACT []
synonym: "mucous membrane of duodenum" EXACT []
is_a: UBERON:0001204 ! mucosa of small intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0000323
name: late embryo
def: "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." []
synonym: "embryo late growth stage" RELATED []
synonym: "embryo late stage" RELATED []
synonym: "fetus" NARROW []
is_a: UBERON:0000922 ! embryo

[Term]
id: UBERON:0000325
name: gastric gland
def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." []
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0003294 ! gland of foregut
relationship: part_of UBERON:0006924 ! stomach glandular epithelium

[Term]
id: UBERON:0000328
name: gut wall
def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." []
synonym: "digestive tract wall" EXACT []
synonym: "wall of alimentary tract" RELATED []
synonym: "wall of digestive tract" EXACT []
synonym: "wall of gut" EXACT []
is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0000331
name: ileal mucosa
def: "A mucosa that is part of a ileum [Automatically generated definition]." []
synonym: "ileal mucous membrane" EXACT []
synonym: "ileum mucosa" EXACT []
synonym: "ileum mucosa of organ" EXACT []
synonym: "ileum mucous membrane" EXACT []
synonym: "ileum organ mucosa" EXACT []
synonym: "mucosa of ileum" EXACT []
synonym: "mucosa of organ of ileum" EXACT []
synonym: "mucous membrane of ileum" EXACT []
synonym: "organ mucosa of ileum" EXACT []
is_a: UBERON:0001204 ! mucosa of small intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: UBERON:0000332
name: yellow bone marrow
def: "bone marrow in which the fat cells predominate in the meshes of the reticular network." []
synonym: "fat marrow" RELATED []
synonym: "medulla ossium flava" EXACT []
synonym: "yellow marrow" EXACT []
is_a: UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0007195 ! stroma of bone marrow

[Term]
id: UBERON:0000333
name: intestinal gland
def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." []
synonym: "bowel mucosa gland" EXACT []
synonym: "bowel mucosa of organ gland" EXACT []
synonym: "bowel mucous membrane gland" EXACT []
synonym: "bowel organ mucosa gland" EXACT []
synonym: "gland of bowel mucosa" EXACT []
synonym: "gland of bowel mucosa of organ" EXACT []
synonym: "gland of bowel mucous membrane" EXACT []
synonym: "gland of bowel organ mucosa" EXACT []
synonym: "gland of intestinal mucosa" EXACT []
synonym: "gland of intestine mucosa" EXACT []
synonym: "gland of intestine mucosa of organ" EXACT []
synonym: "gland of intestine mucous membrane" EXACT []
synonym: "gland of intestine organ mucosa" EXACT []
synonym: "gland of mucosa of bowel" EXACT []
synonym: "gland of mucosa of intestine" EXACT []
synonym: "gland of mucosa of organ of bowel" EXACT []
synonym: "gland of mucosa of organ of intestine" EXACT []
synonym: "gland of mucous membrane of bowel" EXACT []
synonym: "gland of mucous membrane of intestine" EXACT []
synonym: "gland of organ mucosa of bowel" EXACT []
synonym: "gland of organ mucosa of intestine" EXACT []
synonym: "glandula intestinalis" EXACT []
synonym: "glandulae intestinales" RELATED []
synonym: "intestinal mucosa gland" EXACT []
synonym: "intestine mucosa gland" EXACT []
synonym: "intestine mucosa of organ gland" EXACT []
synonym: "intestine mucous membrane gland" EXACT []
synonym: "intestine organ mucosa gland" EXACT []
synonym: "mucosa of bowel gland" EXACT []
synonym: "mucosa of intestine gland" EXACT []
synonym: "mucosa of organ of bowel gland" EXACT []
synonym: "mucosa of organ of intestine gland" EXACT []
synonym: "mucous membrane of bowel gland" EXACT []
synonym: "mucous membrane of intestine gland" EXACT []
synonym: "organ mucosa of bowel gland" EXACT []
synonym: "organ mucosa of intestine gland" EXACT []
is_a: UBERON:0003408 ! gland of gut
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001242 ! intestinal mucosa
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: UBERON:0000344
name: mucosa
def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]" []
synonym: "mucosa of organ" EXACT []
synonym: "mucosa of organ part" EXACT []
synonym: "mucosal region" EXACT []
synonym: "mucous membrane" EXACT []
synonym: "organ mucosa" EXACT []
synonym: "region of mucosa" RELATED []
synonym: "tunica mucosa" RELATED []
is_a: UBERON:0004923 ! organ component layer
relationship: has_part UBERON:0000483 ! epithelium
relationship: has_part UBERON:0002384 ! connective tissue

[Term]
id: UBERON:0000349
name: limbic system
def: "A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]." []
synonym: "visceral brain" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0000353
name: parenchyma
def: "functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." []
is_a: UBERON:0000064 ! organ part
disjoint_from: UBERON:0003891 ! stroma

[Term]
id: UBERON:0000355
name: pharyngeal mucosa
def: "A mucosa that is part of a pharynx [Automatically generated definition]." []
synonym: "mucosa of organ of pharynx" EXACT []
synonym: "mucosa of pharynx" EXACT []
synonym: "Mucous membrane of pharynx" EXACT []
synonym: "mucous membrane of pharynx" EXACT []
synonym: "mucous membrane of the pharynx" RELATED []
synonym: "organ mucosa of pharynx" EXACT []
synonym: "pharynx mucosa" EXACT []
synonym: "pharynx mucosa of organ" EXACT []
synonym: "pharynx mucous membrane" EXACT []
synonym: "pharynx organ mucosa" EXACT []
synonym: "tunica mucosa pharyngea" EXACT []
synonym: "tunica mucosa pharyngis" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004785 ! respiratory system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0000358
name: blastocyst
def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." []
synonym: "blastocystis" RELATED []
synonym: "blastula" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000085 ! morula
relationship: has_part UBERON:0000087 ! inner cell mass
relationship: has_part UBERON:0000088 ! trophoblast
relationship: part_of UBERON:0000307 ! blastula

[Term]
id: UBERON:0000362
name: renal medulla
def: "the inner portion of the kidney consisting of the renal pyramids" []
synonym: "kidney medulla" EXACT []
synonym: "medulla of kidney" EXACT []
synonym: "medulla renalis" EXACT []
synonym: "medullary pyramids" RELATED []
synonym: "pyramides renales" EXACT []
synonym: "renal marrow" RELATED []
synonym: "renal medullae" EXACT []
synonym: "renal medullae set" EXACT []
synonym: "renal pyramids" EXACT []
synonym: "renal pyramids set" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000958 ! medulla of organ
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0002113 ! kidney
relationship: has_part UBERON:0004200 ! kidney pyramid
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0000365
name: urothelium
def: "An epithelial tissue layer that lines much of the urinary tract, including the renal pelvis, the ureters, the bladder, and parts of the urethra." []
synonym: "transitional epithelium" BROAD []
synonym: "uroepithelium" EXACT []
is_a: UBERON:0005910 ! transitional epithelium
intersection_of: UBERON:0005910 ! transitional epithelium
intersection_of: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0000369
name: corpus striatum
def: "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." []
synonym: "striate body" RELATED []
synonym: "striated body" RELATED []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002420 ! basal ganglion

[Term]
id: UBERON:0000376
name: hindlimb stylopod
def: "The part of the hindlimb between pelvis and the knee, corresponding to the femur." []
synonym: "femur" RELATED []
synonym: "hind limb stylopod" EXACT []
synonym: "hind limb stylopodium" EXACT []
synonym: "hind propodium" EXACT []
synonym: "hindlimb propodium" EXACT []
synonym: "hindlimb stylopod" EXACT []
synonym: "hindlimb stylopodium" EXACT []
synonym: "inferior member stylopod" EXACT []
synonym: "lower extremity stylopod" EXACT []
synonym: "proximal segment of free lower limb" EXACT []
synonym: "stylopod of hind limb" EXACT []
synonym: "stylopod of hindlimb" EXACT []
synonym: "stylopod of inferior member" EXACT []
synonym: "stylopod of lower extremity" EXACT []
synonym: "stylopod of lower limb" EXACT []
synonym: "thigh" EXACT []
synonym: "upper leg" EXACT []
is_a: UBERON:0002472 ! stylopod
is_a: UBERON:0008784 ! lower limb segment
intersection_of: UBERON:0002472 ! stylopod
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0000378
name: tongue muscle
def: "The muscular portion of the tongue." []
synonym: "muscle of tongue" EXACT []
synonym: "muscle organ of tongue" EXACT []
synonym: "musculi linguae" RELATED []
synonym: "skeletal muscle tissue of tongue" EXACT []
synonym: "tongue skeletal muscle" EXACT []
synonym: "tongue skeletal muscle tissue" EXACT []
is_a: UBERON:0010959 ! craniocervical muscle
is_a: UBERON:0013765 ! digestive system element
union_of: UBERON:0001575 ! extrinsic muscle of tongue
union_of: UBERON:0001576 ! intrinsic muscle of tongue
relationship: develops_from UBERON:0005594 ! head somite
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0000379
name: tracheal mucosa
def: "A mucosa that is part of a respiratory airway." []
synonym: "mucosa of organ of trachea" EXACT []
synonym: "mucosa of organ of windpipe" EXACT []
synonym: "mucosa of trachea" EXACT []
synonym: "mucosa of windpipe" EXACT []
synonym: "Mucous membrane of trachea" EXACT []
synonym: "mucous membrane of trachea" EXACT []
synonym: "mucous membrane of windpipe" EXACT []
synonym: "organ mucosa of trachea" EXACT []
synonym: "organ mucosa of windpipe" EXACT []
synonym: "trachea mucosa" EXACT []
synonym: "trachea mucosa of organ" EXACT []
synonym: "trachea mucous membrane" EXACT []
synonym: "trachea organ mucosa" EXACT []
synonym: "Tracheal mucous membrane" EXACT []
synonym: "Tunica mucosa (tracheae)" EXACT []
synonym: "tunica mucosa tracheae" EXACT []
synonym: "windpipe mucosa" EXACT []
synonym: "windpipe mucosa of organ" EXACT []
synonym: "windpipe mucous membrane" EXACT []
synonym: "windpipe organ mucosa" EXACT []
is_a: UBERON:0004785 ! respiratory system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001005 ! respiratory airway
relationship: part_of UBERON:0001005 ! respiratory airway

[Term]
id: UBERON:0000383
name: musculature of body
def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." []
synonym: "muscle system" EXACT []
synonym: "muscle system of body" EXACT []
synonym: "muscular system" EXACT []
synonym: "musculature system" EXACT []
synonym: "muskelsystem" RELATED []
synonym: "set of all muscles" EXACT []
synonym: "set of muscles of body" EXACT []
synonym: "vertebrate muscular system" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0002204 ! musculoskeletal system

[Term]
id: UBERON:0000395
name: cochlear ganglion
def: "The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus." []
synonym: "cochlear part of vestibulocochlear ganglion" EXACT []
synonym: "Corti's ganglion" EXACT []
synonym: "ganglion cochlearis" RELATED []
synonym: "ganglion of Corti" EXACT []
synonym: "ganglion spirale" RELATED []
synonym: "ganglion spirale cochleae" RELATED []
synonym: "spiral ganglion" EXACT []
synonym: "spiral ganglion of cochlea" RELATED []
synonym: "vestibulocochlear ganglion cochlear component" RELATED []
synonym: "vestibulocochlear VIII ganglion cochlear component" EXACT []
is_a: UBERON:0001714 ! cranial ganglion
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: part_of UBERON:0002827 ! vestibulocochlear ganglion
relationship: part_of UBERON:0016490 ! auditory system

[Term]
id: UBERON:0000397
name: colonic epithelium
def: "An epithelium that is part of a colon [Automatically generated definition]." []
synonym: "colon epithelial tissue" EXACT []
synonym: "Colon epithelium" EXACT []
synonym: "colon epithelium" EXACT []
synonym: "epithelial tissue of colon" EXACT []
synonym: "epithelial tissue of large bowel" EXACT []
synonym: "epithelium of colon" EXACT []
synonym: "epithelium of large bowel" EXACT []
synonym: "large bowel epithelial tissue" EXACT []
synonym: "large bowel epithelium" EXACT []
synonym: "posterior intestine epithelium" EXACT []
is_a: UBERON:0001278 ! epithelium of large intestine
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0000399
name: jejunal mucosa
def: "A mucosa that is part of a jejunum [Automatically generated definition]." []
synonym: "jejunal mucous membrane" EXACT []
synonym: "jejunum mucosa" EXACT []
synonym: "jejunum mucosa of organ" EXACT []
synonym: "jejunum mucous membrane" EXACT []
synonym: "jejunum organ mucosa" EXACT []
synonym: "mucosa of jejunum" EXACT []
synonym: "mucosa of organ of jejunum" EXACT []
synonym: "mucous membrane of jejunum" EXACT []
synonym: "organ mucosa of jejunum" EXACT []
is_a: UBERON:0001204 ! mucosa of small intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0000400
name: jejunal epithelium
def: "An epithelium that is part of a jejunum." []
synonym: "epithelium of jejunum" EXACT []
is_a: UBERON:0013636 ! epithelium of intestinal villus
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0008343 ! intestinal villus of jejunum

[Term]
id: UBERON:0000403
name: scalp
def: "The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL)." []
synonym: "scalpus" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0034921 ! multi organ part structure
relationship: has_part UBERON:0000014 ! zone of skin
relationship: has_part UBERON:0002384 ! connective tissue
relationship: has_part UBERON:0002515 ! periosteum
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0000409
name: serous gland
def: "A gland in which the principal secretory cells are serous secreting cells." []
is_a: UBERON:0002365 ! exocrine gland
relationship: has_part UBERON:0013232 ! serous acinus

[Term]
id: UBERON:0000410
name: bronchial mucosa
def: "A mucosa that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi mucosa" EXACT []
synonym: "bronchi mucosa of organ" EXACT []
synonym: "bronchi mucous membrane" EXACT []
synonym: "bronchi organ mucosa" EXACT []
synonym: "bronchial trunk mucosa" EXACT []
synonym: "bronchial trunk mucosa of organ" EXACT []
synonym: "bronchial trunk mucous membrane" EXACT []
synonym: "bronchial trunk organ mucosa" EXACT []
synonym: "bronchus mucosa" EXACT []
synonym: "bronchus mucosa of organ" EXACT []
synonym: "bronchus mucous membrane" EXACT []
synonym: "bronchus organ mucosa" EXACT []
synonym: "mucosa of bronchi" EXACT []
synonym: "mucosa of bronchial trunk" EXACT []
synonym: "mucosa of bronchus" EXACT []
synonym: "mucosa of organ of bronchi" EXACT []
synonym: "mucosa of organ of bronchial trunk" EXACT []
synonym: "mucosa of organ of bronchus" EXACT []
synonym: "mucous membrane of bronchi" EXACT []
synonym: "mucous membrane of bronchial trunk" EXACT []
synonym: "Mucous membrane of bronchus" EXACT []
synonym: "mucous membrane of bronchus" EXACT []
synonym: "organ mucosa of bronchi" EXACT []
synonym: "organ mucosa of bronchial trunk" EXACT []
synonym: "organ mucosa of bronchus" EXACT []
synonym: "tunica mucosa bronchi" EXACT []
is_a: UBERON:0000379 ! tracheal mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0000412
name: dermal papilla
def: "A mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts. Framed by the enlarged bulb matrix in anagen." []
synonym: "dermal papilla cell" RELATED []
synonym: "dermal papillae" EXACT []
synonym: "follicular papilla" EXACT []
synonym: "hair follicle dermal papilla" RELATED []
synonym: "hair papilla" RELATED []
synonym: "papilla corii" RELATED []
synonym: "papilla dermatis" RELATED []
synonym: "papilla dermis" RELATED []
synonym: "papilla of corium" RELATED []
synonym: "papillae dermis" RELATED []
synonym: "skin papilla" RELATED []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001992 ! papillary layer of dermis

[Term]
id: UBERON:0000414
name: mucous gland
def: "A gland in which the principal secretory cells are mucus secreting cells." []
synonym: "glandula mucosa" EXACT []
synonym: "muciparous gland" RELATED []
synonym: "mucous secreting gland" RELATED []
synonym: "mucus gland" RELATED []
synonym: "mucus-secreting gland" RELATED []
is_a: UBERON:0002365 ! exocrine gland

[Term]
id: UBERON:0000415
name: artery wall
def: "An anatomical wall that is part of an artery [Automatically generated definition]." []
synonym: "Arterial wall" EXACT []
synonym: "wall of artery" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0000423
name: eccrine sweat gland
def: "A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion." []
synonym: "eccrine gland" RELATED []
synonym: "glandula sudorifera eccrina" EXACT []
synonym: "glandula sudorifera merocrina" EXACT []
synonym: "merocrine sweat gland" RELATED []
is_a: UBERON:0001820 ! sweat gland
is_a: UBERON:0010243 ! merocrine gland
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0000428
name: prostate epithelium
def: "The prostate epithelium." []
synonym: "epithelial tissue of prostate" EXACT []
synonym: "epithelial tissue of prostate gland" EXACT []
synonym: "epithelium of prostate" EXACT []
synonym: "epithelium of prostate gland" EXACT []
synonym: "epithelium of prostatic gland" EXACT []
synonym: "prostate epithelial tissue" EXACT []
synonym: "prostate gland epithelial tissue" EXACT []
synonym: "prostate gland epithelium" EXACT []
synonym: "prostatic epithelium" EXACT []
synonym: "prostatic gland epithelium" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0000444
name: lymphoid follicle
def: "." []
synonym: "folliculus lymphaticus" RELATED []
synonym: "lymphatic follicle" RELATED []
synonym: "lymphatic nodule" RELATED []
synonym: "lymphoid nodule" EXACT []
synonym: "nodular lymphoid tissue" EXACT []
synonym: "nodulus lymphaticus" RELATED []
synonym: "nodulus lymphoideus" RELATED []
is_a: UBERON:0001744 ! lymphoid tissue

[Term]
id: UBERON:0000454
name: cerebral subcortex
def: "The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain." []
synonym: "cerebral medulla" EXACT []
synonym: "subcortex" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0000458
name: endocervix
def: "1. The mucous membrane lining the canal of the cervix uteri. 2. The region of the opening of the uterine cervix into the uterine cavity." []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0005156 ! reproductive structure
relationship: has_part UBERON:0000485 ! simple columnar epithelium

[Term]
id: UBERON:0000459
name: uterine wall
def: "An anatomical wall that is part of a uterus [Automatically generated definition]." []
synonym: "anatomical wall of uterus" EXACT []
synonym: "uterus anatomical wall" EXACT []
synonym: "uterus wall" EXACT []
synonym: "wall of uterus" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0000463
name: organism substance
def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." []
synonym: "body fluid or substance" EXACT []
synonym: "body substance" EXACT []
synonym: "organism substance" EXACT []
synonym: "portion of body substance" EXACT []
synonym: "portion of organism substance" EXACT []
is_a: UBERON:0000465 ! material anatomical entity
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0000464
name: anatomical space
def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." []
synonym: "anatomical spaces" RELATED []
synonym: "lumen" BROAD []
synonym: "lumen space" EXACT []
synonym: "space" BROAD []
is_a: UBERON:0000466 ! immaterial anatomical entity

[Term]
id: UBERON:0000465
name: material anatomical entity
def: "Anatomical entity that has mass." []
is_a: UBERON:0001062 ! anatomical entity

[Term]
id: UBERON:0000466
name: immaterial anatomical entity
def: "Anatomical entity that has no mass." []
synonym: "immaterial physical anatomical entity" EXACT []
is_a: UBERON:0001062 ! anatomical entity

[Term]
id: UBERON:0000467
name: anatomical system
def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." []
synonym: "anatomical systems" RELATED []
synonym: "body system" EXACT []
synonym: "connected anatomical system" EXACT []
synonym: "organ system" EXACT []
synonym: "system" BROAD []
is_a: UBERON:0000061 ! anatomical structure
relationship: has_part UBERON:0000062 ! organ
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0000468
name: multicellular organism
def: "Anatomical structure that is an individual member of a species and consists of more than one cell." []
synonym: "animal" NARROW []
synonym: "body" RELATED []
synonym: "Koerper" RELATED []
synonym: "multi-cellular organism" EXACT []
synonym: "organism" EXACT []
synonym: "whole body" RELATED []
synonym: "whole organism" EXACT []
is_a: UBERON:0010000 ! multicellular anatomical structure

[Term]
id: UBERON:0000471
name: compound organ component
def: "Multi-tissue structure that is part of a compound organ." []
synonym: "compound organ components" RELATED []
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0003103 ! compound organ

[Term]
id: UBERON:0000473
name: testis
def: "A gonad of a male animal. A gonad produces and releases sperm." []
synonym: "gonad of male genitalia" EXACT []
synonym: "gonad of male reproductive system" EXACT []
synonym: "male gonad" EXACT []
synonym: "orchis" RELATED []
synonym: "testes" RELATED []
synonym: "testicle" EXACT []
synonym: "testiculus" RELATED []
is_a: UBERON:0000991 ! gonad
is_a: UBERON:0003135 ! male reproductive organ
intersection_of: UBERON:0000991 ! gonad
intersection_of: part_of UBERON:0000079 ! male reproductive system
disjoint_from: UBERON:0000992 ! female gonad
disjoint_from: UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0000474
name: female reproductive system
def: "The organs and associated structures associated with bearing offspring in a female animal." []
synonym: "female genital system" RELATED []
synonym: "female genital tract" RELATED []
synonym: "female genitalia" RELATED []
synonym: "female genitals" RELATED []
synonym: "female organism genitalia" EXACT []
synonym: "female organism reproductive system" EXACT []
synonym: "female reproductive tract" RELATED []
synonym: "genitalia of female organism" EXACT []
synonym: "gynaecological tissue" RELATED []
synonym: "reproductive system of female organism" EXACT []
synonym: "systema genitale femininum" RELATED []
is_a: UBERON:0000990 ! reproductive system
intersection_of: UBERON:0000990 ! reproductive system
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0003100 ! female organism

[Term]
id: UBERON:0000475
name: organism subdivision
def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." []
synonym: "anatomic region" EXACT []
synonym: "body part" RELATED []
synonym: "body region" RELATED []
synonym: "cardinal body part" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0000476
name: acellular anatomical structure
def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." []
synonym: "acellular anatomical structures" RELATED []
is_a: UBERON:0000061 ! anatomical structure
disjoint_from: UBERON:0010000 ! multicellular anatomical structure

[Term]
id: UBERON:0000477
name: anatomical cluster
def: "Anatomical group that has its parts adjacent to one another." []
is_a: UBERON:0001062 ! anatomical entity

[Term]
id: UBERON:0000478
name: extraembryonic structure
def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." []
synonym: "extra-embryonic structure" EXACT []
synonym: "extraembryonic structures" RELATED []
synonym: "extraembryonic tissue" RELATED []
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: part_of UBERON:0016887 ! entire extraembryonic component
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0000479
name: tissue
def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." []
synonym: "portion of tissue" EXACT []
synonym: "simple tissue" NARROW []
synonym: "tissue portion" EXACT []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0000481
name: multi-tissue structure
def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." []
synonym: "multi-tissue structures" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: has_part UBERON:0000479 ! tissue

[Term]
id: UBERON:0000483
name: epithelium
def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." []
synonym: "epithelial tissue" EXACT []
synonym: "portion of epithelium" EXACT []
is_a: UBERON:0000479 ! tissue
union_of: UBERON:0000486 ! multilaminar epithelium
union_of: UBERON:0000490 ! unilaminar epithelium
relationship: has_part UBERON:0005769 ! basement membrane of epithelium

[Term]
id: UBERON:0000484
name: simple cuboidal epithelium
def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." []
synonym: "epithelium simplex cuboideum" EXACT []
synonym: "simple cuboidal epithelia" RELATED []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010077 ! cuboidal epithelium

[Term]
id: UBERON:0000485
name: simple columnar epithelium
def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]" []
synonym: "columnar epithelium" BROAD []
synonym: "columnar epithlium" BROAD []
synonym: "epithelium simplex columnare" EXACT []
synonym: "simple columnar epithelia" RELATED []
synonym: "simple columnar epithelium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0012274 ! columnar epithelium

[Term]
id: UBERON:0000486
name: multilaminar epithelium
def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]" []
synonym: "laminated epithelium" RELATED []
synonym: "stratified epithelium" EXACT []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0000487
name: simple squamous epithelium
def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]" []
synonym: "epithelium simplex squamosum" EXACT []
synonym: "simple squamous epithelia" RELATED []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium

[Term]
id: UBERON:0000488
name: atypical epithelium
def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." []
synonym: "atypical epithelia" RELATED []
synonym: "heterogenous epithelium" EXACT []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0000489
name: cavitated compound organ
def: "Compound organ that contains one or more macroscopic anatomical spaces." []
synonym: "cavitated compound organs" RELATED []
synonym: "cavitated organ" EXACT []
is_a: UBERON:0003103 ! compound organ
intersection_of: UBERON:0003103 ! compound organ
intersection_of: has_part UBERON:0002553 ! anatomical cavity
relationship: has_part UBERON:0002553 ! anatomical cavity

[Term]
id: UBERON:0000490
name: unilaminar epithelium
def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]" []
synonym: "simple epithelium" EXACT []
synonym: "unilaminar epithelia" RELATED []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0000913
name: interstitial fluid
def: "Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid." []
synonym: "intercellular fluid" EXACT []
synonym: "tissue fluid" EXACT []
is_a: UBERON:0000463 ! organism substance

[Term]
id: UBERON:0000915
name: thoracic segment of trunk
def: "Subdivision of trunk that lies between the head and the abdomen." []
synonym: "anterior subdivision of trunk" RELATED []
synonym: "thorax" EXACT []
synonym: "upper body" RELATED []
synonym: "upper trunk" RELATED []
is_a: UBERON:0009569 ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis

[Term]
id: UBERON:0000916
name: abdomen
def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." []
synonym: "abdominopelvic region" EXACT []
synonym: "abdominopelvis" EXACT []
synonym: "adult abdomen" RELATED []
synonym: "belly" RELATED []
synonym: "celiac region" RELATED []
is_a: UBERON:0009569 ! subdivision of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0000922
name: embryo
def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." []
synonym: "developing organism" RELATED []
synonym: "developmental tissue" RELATED []
synonym: "embryonic organism" EXACT []
is_a: UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0000923
name: germ layer
def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." []
synonym: "embryonic germ layer" RELATED []
synonym: "embryonic germ layers" RELATED []
synonym: "embryonic tissue" BROAD []
synonym: "germinal layer" EXACT []
synonym: "primary germ layer" NARROW []
is_a: UBERON:0010316 ! germ layer / neural crest
relationship: develops_from UBERON:0002532 ! epiblast (generic)
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0000924
name: ectoderm
def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." []
synonym: "embryonic ectoderm" EXACT []
is_a: UBERON:0000923 ! germ layer

[Term]
id: UBERON:0000925
name: endoderm
def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." []
synonym: "entoderm" RELATED []
is_a: UBERON:0000923 ! germ layer

[Term]
id: UBERON:0000926
name: mesoderm
def: "The middle germ layer of the embryo, between the endoderm and ectoderm." []
synonym: "embryonic mesoderm" RELATED []
synonym: "entire mesoderm" RELATED []
synonym: "mesodermal mantle" RELATED []
is_a: UBERON:0000923 ! germ layer

[Term]
id: UBERON:0000930
name: stomodeum
def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." []
synonym: "mouth pit" RELATED []
synonym: "mouth primordium" EXACT []
synonym: "oral ectoderm" RELATED []
synonym: "oral pit" RELATED []
synonym: "primitive oral cavity" EXACT []
synonym: "stomatodeum" EXACT []
synonym: "stomodaeum" EXACT []
synonym: "stomodeal-hypophyseal primordium" BROAD []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0013522 ! subdivision of tube
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth

[Term]
id: UBERON:0000945
name: stomach
def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." []
synonym: "anterior intestine" RELATED []
synonym: "gaster" RELATED []
synonym: "mesenteron" RELATED []
synonym: "stomach chamber" NARROW []
synonym: "Ventricular" RELATED []
synonym: "ventriculus" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0010039 ! food storage organ
relationship: part_of UBERON:0001041 ! foregut

[Term]
id: UBERON:0000947
name: aorta
def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation" []
synonym: "arteria maxima" RELATED []
synonym: "dorsal aorta" NARROW []
synonym: "trunk of aortic tree" EXACT []
synonym: "trunk of systemic arterial tree" EXACT []
is_a: UBERON:0003509 ! arterial blood vessel
is_a: UBERON:0003519 ! thoracic cavity blood vessel
is_a: UBERON:0013768 ! great vessel of heart
relationship: part_of UBERON:0010191 ! aortic system

[Term]
id: UBERON:0000948
name: heart
def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." []
synonym: "branchial heart" NARROW []
synonym: "cardium" RELATED []
synonym: "chambered heart" EXACT []
synonym: "Herz@de" RELATED []
synonym: "vertebrate heart" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005181 ! thoracic segment organ
is_a: UBERON:0007100 ! primary circulatory organ
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0007100 ! primary circulatory organ
intersection_of: has_part UBERON:0004151 ! cardiac chamber
relationship: develops_from UBERON:0004141 ! heart tube
relationship: has_part UBERON:0004151 ! cardiac chamber
relationship: part_of UBERON:0015410 ! heart plus pericardium

[Term]
id: UBERON:0000949
name: endocrine system
def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." []
synonym: "endocrine glandular system" EXACT []
synonym: "endocrine system" EXACT []
synonym: "systema endocrinum" EXACT []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0000990 ! reproductive system
disjoint_from: UBERON:0001004 ! respiratory system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001008 ! renal system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0000955
name: brain
def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." []
synonym: "encephalon" RELATED []
synonym: "suprasegmental levels of nervous system" RELATED []
synonym: "suprasegmental structures" RELATED []
synonym: "synganglion" RELATED []
synonym: "the brain" RELATED []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0000956
name: cerebral cortex
def: "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." []
synonym: "brain cortex" RELATED []
synonym: "cortex cerebralis" RELATED []
synonym: "cortex cerebri" RELATED []
synonym: "cortex of cerebral hemisphere" EXACT []
synonym: "cortical plate (areas)" RELATED []
synonym: "cortical plate (CTXpl)" RELATED []
synonym: "pallium of the brain" RELATED []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0016548 ! central nervous system gray matter layer
relationship: part_of UBERON:0000203 ! pallium
relationship: part_of UBERON:0005401 ! cerebral hemisphere gray matter

[Term]
id: UBERON:0000957
name: lamina
def: "Any thin layer or plate." []
synonym: "laminar tissue" EXACT []
is_a: UBERON:0000479 ! tissue

[Term]
id: UBERON:0000958
name: medulla of organ
def: "Middle part of an organ, surrounded by the cortex." []
synonym: "medulla" EXACT []
is_a: UBERON:0000471 ! compound organ component

[Term]
id: UBERON:0000964
name: cornea
def: "the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" []
synonym: "cornea of camera-type eye" EXACT []
synonym: "corneas" RELATED []
synonym: "tunica cornea" RELATED []
is_a: UBERON:0003102 ! surface structure
is_a: UBERON:0010000 ! multicellular anatomical structure
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0004348 ! optic eminence
relationship: develops_from UBERON:0005427 ! corneal primordium
relationship: has_part UBERON:0001772 ! corneal epithelium
relationship: has_part UBERON:0004370 ! anterior limiting lamina of cornea
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
relationship: part_of UBERON:0010409 ! ocular surface region
relationship: part_of UBERON:0012430 ! tunica fibrosa of eyeball

[Term]
id: UBERON:0000965
name: lens of camera-type eye
def: "Transparent part of camera-type eye that helps to refract light to be focused on the retina." []
synonym: "camera-type eye lens" EXACT []
synonym: "crystalline lens" RELATED []
synonym: "eye lens" EXACT []
synonym: "lens" EXACT []
synonym: "lens crystallina" EXACT []
synonym: "lenses" RELATED []
synonym: "ocular lens" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005389 ! transparent eye structure
relationship: develops_from UBERON:0003073 ! lens placode
relationship: develops_from UBERON:0005426 ! lens vesicle
relationship: part_of UBERON:0001801 ! anterior segment of eyeball

[Term]
id: UBERON:0000966
name: retina
def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." []
synonym: "inner layer of eyeball" EXACT []
synonym: "Netzhaut" RELATED []
synonym: "retina of camera-type eye" EXACT []
synonym: "retinas" RELATED []
synonym: "tunica interna of eyeball" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005388 ! photoreceptor array
relationship: develops_from UBERON:0003072 ! optic cup
relationship: part_of UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0019207 ! chorioretinal region

[Term]
id: UBERON:0000970
name: eye
def: "An organ that detects light." []
synonym: "light-detecting organ" RELATED []
synonym: "visual apparatus" RELATED []
is_a: UBERON:0000020 ! sense organ
relationship: part_of UBERON:0002104 ! visual system

[Term]
id: UBERON:0000977
name: pleura
def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." []
synonym: "pleura" RELATED []
synonym: "pleural tissue" RELATED []
synonym: "wall of pleural sac" EXACT []
is_a: UBERON:0000042 ! serous membrane
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: has_part UBERON:0002400 ! parietal pleura
intersection_of: has_part UBERON:0002401 ! visceral pleura
intersection_of: part_of UBERON:0009778 ! pleural sac
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: has_part UBERON:0002400 ! parietal pleura
relationship: has_part UBERON:0002401 ! visceral pleura
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0009778 ! pleural sac

[Term]
id: UBERON:0000978
name: leg
def: "The portion of the hindlimb that contains both the stylopod and zeugopod." []
synonym: "lower extremity" RELATED []
synonym: "tetrapod leg" EXACT []
is_a: UBERON:0006058 ! multi-limb segment region
is_a: UBERON:0008784 ! lower limb segment
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0000981
name: femur
def: "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified]." []
synonym: "femoral bone" RELATED []
synonym: "mesomere 1 of pevlic appendage" RELATED []
synonym: "os femorale" RELATED []
synonym: "os femoris" RELATED []
synonym: "os longissimum" RELATED []
synonym: "proximal metapterygial mesomere of pelvic appendage" RELATED []
synonym: "proximal metapterygial mesomere of pelvic fin" RELATED []
synonym: "thigh bone" EXACT []
is_a: UBERON:0003608 ! hindlimb long bone
is_a: UBERON:0003826 ! upper leg bone
is_a: UBERON:0008202 ! bone of hip region
is_a: UBERON:0015052 ! femur endochondral element
relationship: develops_from UBERON:0010129 ! femur cartilage element
relationship: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0001441 ! hindlimb skeleton

[Term]
id: UBERON:0000982
name: skeletal joint
def: "Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." []
synonym: "articular joint" RELATED []
synonym: "articulation" BROAD []
synonym: "joint" BROAD []
synonym: "joints" RELATED []
is_a: UBERON:0004905 ! articulation
union_of: UBERON:0002217 ! synovial joint
union_of: UBERON:0011134 ! nonsynovial joint
disjoint_from: UBERON:0001474 ! bone element
relationship: part_of UBERON:0004770 ! articular system

[Term]
id: UBERON:0000989
name: penis
def: "A intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination" []
synonym: "penes" RELATED []
synonym: "phallus" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0008811 ! intromittent organ
relationship: develops_from UBERON:0004876 ! urogenital fold
relationship: develops_from UBERON:0005876 ! undifferentiated genital tubercle

[Term]
id: UBERON:0000990
name: reproductive system
def: "Anatomical system that has as its parts the organs concerned with reproduction." []
synonym: "animal reproductive system" RELATED []
synonym: "genital system" RELATED []
synonym: "genital tract" RELATED []
synonym: "genitalia" RELATED []
synonym: "Geschlechtsorgan" RELATED []
synonym: "organa genitalia" RELATED []
synonym: "reproductive tissue" RELATED []
synonym: "reproductive tract" RELATED []
synonym: "systemata genitalia" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001004 ! respiratory system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001008 ! renal system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0000991 ! gonad

[Term]
id: UBERON:0000991
name: gonad
def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." []
synonym: "gonada" EXACT []
synonym: "gonads" RELATED []
is_a: UBERON:0003133 ! reproductive organ
relationship: develops_from UBERON:0005564 ! gonad primordium
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0000992
name: female gonad
def: "the gonad of a female organism which contains germ cells" []
synonym: "female organism genitalia gonad" EXACT []
synonym: "female organism genitalia gonada" EXACT []
synonym: "female organism reproductive system gonad" EXACT []
synonym: "female organism reproductive system gonada" EXACT []
synonym: "female reproductive system gonad" EXACT []
synonym: "female reproductive system gonada" EXACT []
synonym: "genitalia of female organism gonad" EXACT []
synonym: "genitalia of female organism gonada" EXACT []
synonym: "gonad of female organism genitalia" EXACT []
synonym: "gonad of female organism reproductive system" EXACT []
synonym: "gonad of female reproductive system" EXACT []
synonym: "gonad of genitalia of female organism" EXACT []
synonym: "gonad of reproductive system of female organism" EXACT []
synonym: "gonada of female organism genitalia" EXACT []
synonym: "gonada of female organism reproductive system" EXACT []
synonym: "gonada of female reproductive system" EXACT []
synonym: "gonada of genitalia of female organism" EXACT []
synonym: "gonada of reproductive system of female organism" EXACT []
synonym: "ovaries" RELATED []
synonym: "ovarium" RELATED []
synonym: "ovary" EXACT []
synonym: "ovum-producing ovary" EXACT []
synonym: "reproductive system of female organism gonad" EXACT []
synonym: "reproductive system of female organism gonada" EXACT []
is_a: UBERON:0000991 ! gonad
is_a: UBERON:0003134 ! female reproductive organ
intersection_of: UBERON:0000991 ! gonad
intersection_of: part_of UBERON:0000474 ! female reproductive system
disjoint_from: UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: part_of UBERON:0000474 ! female reproductive system

[Term]
id: UBERON:0000993
name: oviduct
def: "A tube or collection of tubes in an animal from the ovaries to the outside of the body." []
synonym: "female reproductive tracts" RELATED []
synonym: "ovarian duct" EXACT []
synonym: "ovarian tube" EXACT []
synonym: "oviducts" RELATED []
synonym: "tuba uterina" RELATED []
synonym: "tuba uterinae" RELATED []
synonym: "tubular parts of female reproductive system" RELATED []
synonym: "uterine tube" EXACT []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0005156 ! reproductive structure
relationship: part_of UBERON:0000474 ! female reproductive system

[Term]
id: UBERON:0000995
name: uterus
def: "the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth" []
is_a: UBERON:0013515 ! subdivision of oviduct
relationship: part_of UBERON:0004175 ! internal genitalia

[Term]
id: UBERON:0000996
name: vagina
def: "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." []
synonym: "distal oviductal region" RELATED []
synonym: "distal portion of oviduct" RELATED []
synonym: "vaginae" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013515 ! subdivision of oviduct
relationship: develops_from UBERON:0000164 ! primitive urogenital sinus
relationship: part_of UBERON:0003975 ! internal female genitalia

[Term]
id: UBERON:0000998
name: seminal vesicle
def: "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." []
synonym: "glandula seminalis" RELATED []
synonym: "glandula vesiculosa" RELATED []
synonym: "gonecyst" RELATED []
synonym: "seminal gland" BROAD []
synonym: "vas efferens" RELATED []
synonym: "vesicula seminalis" RELATED []
synonym: "vesiculae seminales" RELATED []
synonym: "vesicular gland" RELATED []
synonym: "vesicular glands" RELATED []
synonym: "vesicular seminalis" RELATED []
synonym: "vesiculæ seminales" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006868 ! seminal fluid secreting gland
relationship: develops_from UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0001003
name: skin epidermis
def: "The outer epithelial layer of the skin that is superficial to the dermis." []
synonym: "epidermis" BROAD []
synonym: "skin" BROAD []
synonym: "vertebrate epidermis" EXACT []
is_a: UBERON:0007376 ! outer epithelium
is_a: UBERON:3000961 ! external integument structure
intersection_of: UBERON:0007376 ! outer epithelium
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: UBERON:0001004
name: respiratory system
def: "Functional system which consists of structures involved in respiration." []
synonym: "apparatus respiratorius" EXACT []
synonym: "apparatus respiratorius" RELATED []
synonym: "Atmungssystem" RELATED []
synonym: "respiratory system" EXACT []
synonym: "systema respiratorium" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001008 ! renal system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001005
name: respiratory airway
def: "An airway through which respiratory air passes in organisms." []
synonym: "airway" BROAD []
synonym: "airways" BROAD []
is_a: UBERON:0003103 ! compound organ
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0001007
name: digestive system
def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." []
synonym: "alimentary system" RELATED []
synonym: "alimentary tract" RELATED []
synonym: "gastrointestinal system" RELATED []
synonym: "gut" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001008 ! renal system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001008
name: renal system
def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.." []
synonym: "excretory system" EXACT []
synonym: "renal or urinary system" RELATED []
synonym: "renal system" EXACT []
synonym: "renal/urinary system" RELATED []
synonym: "systema urinaria" EXACT []
synonym: "systema urinarium" EXACT []
synonym: "urinary system" EXACT []
synonym: "urinary tract" EXACT []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001009
name: circulatory system
def: "organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." []
synonym: "systema cardiovasculare" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001013
name: adipose tissue
def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue" []
synonym: "adipose" RELATED []
synonym: "bodyfat" RELATED []
synonym: "fat" EXACT []
synonym: "fat tissue" EXACT []
synonym: "fatty depot" RELATED []
synonym: "fatty tissue" EXACT []
is_a: UBERON:0011822 ! dense irregular connective tissue

[Term]
id: UBERON:0001015
name: musculature
def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." []
synonym: "muscle group" EXACT []
synonym: "muscle system" RELATED []
synonym: "muscles" RELATED []
synonym: "muscles set" EXACT []
synonym: "musculature" EXACT []
synonym: "musculature system" RELATED []
synonym: "musculi" EXACT []
synonym: "set of muscles" EXACT []
synonym: "set of skeletal muscles" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0000383 ! musculature of body

[Term]
id: UBERON:0001016
name: nervous system
def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." []
synonym: "nerve net" NARROW []
synonym: "neurological system" EXACT []
synonym: "systema nervosum" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001017
name: central nervous system
def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." []
synonym: "cerebrospinal axis" NARROW []
synonym: "CNS" EXACT []
synonym: "neuraxis" RELATED []
synonym: "systema nervosum centrale" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0001021
name: nerve
def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." []
synonym: "nerves" EXACT []
synonym: "neural subtree" RELATED []
synonym: "peripheral nerve" EXACT []
is_a: UBERON:0000122 ! neuron projection bundle
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0001032
name: sensory system
def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." []
synonym: "organa sensuum" EXACT []
synonym: "organa sensuum" RELATED []
synonym: "sense organ subsystem" EXACT []
synonym: "sense organs" EXACT []
synonym: "sense organs set" EXACT []
synonym: "sensory organ system" RELATED []
synonym: "sensory subsystem" EXACT []
synonym: "sensory systems" EXACT []
synonym: "set of sense organs" RELATED []
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001033
name: gustatory system
def: "The sensory system for the sense of taste." []
synonym: "gustatory organ system" EXACT []
synonym: "taste system" EXACT []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0001037
name: strand of hair
def: "A filament, mostly protein, that grows from follicles found in the dermis[WP]." []
synonym: "coat hair" RELATED []
synonym: "coat/ hair" RELATED []
synonym: "fur" RELATED []
synonym: "hair" EXACT []
synonym: "microchaeta" RELATED []
synonym: "quill" RELATED []
synonym: "setulae" RELATED []
synonym: "vibrissa" RELATED []
synonym: "whisker" RELATED []
is_a: UBERON:0000021 ! cutaneous appendage
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0011932 ! pilosebaceous unit

[Term]
id: UBERON:0001040
name: yolk sac
def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." []
synonym: "saccus vitellinus" RELATED []
synonym: "vesicula umbilicalis" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005292 ! extraembryonic tissue
is_a: UBERON:0005631 ! extraembryonic membrane
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0000925 ! endoderm
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm

[Term]
id: UBERON:0001041
name: foregut
def: "Anterior subdivision of a digestive tract." []
synonym: "praeenteron" RELATED []
synonym: "proenteron" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract

[Term]
id: UBERON:0001042
name: chordate pharynx
def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." []
synonym: "pharynx" BROAD []
is_a: UBERON:0004185 ! endodermal part of digestive tract
is_a: UBERON:0006562 ! pharynx
relationship: develops_from UBERON:0009145 ! pharyngeal region of foregut
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0001043
name: esophagus
def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." []
synonym: "gullet" EXACT []
synonym: "oesophagus" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0005178 ! thoracic cavity element
is_a: UBERON:0013765 ! digestive system element
relationship: develops_from UBERON:0001041 ! foregut
relationship: part_of UBERON:0004908 ! upper digestive tract

[Term]
id: UBERON:0001044
name: saliva-secreting gland
def: "saliva-secreting exocrine glands of the oral cavity[GO]" []
synonym: "glandulae salivariae" RELATED []
synonym: "salivary gland" EXACT []
is_a: UBERON:0010047 ! oral gland
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0001045
name: midgut
def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." []
synonym: "mesenteron" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract

[Term]
id: UBERON:0001046
name: hindgut
def: "The caudalmost subdivision of a digestive tract." []
synonym: "metenteron" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0001048
name: primordium
def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." []
synonym: "bud" RELATED []
synonym: "future organ" RELATED []
synonym: "placode" RELATED []
synonym: "primordia" RELATED []
synonym: "rudiment" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0001049
name: neural tube
def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." []
synonym: "neural primordium" RELATED []
synonym: "presumptive central nervous system" RELATED []
synonym: "tubus neuralis" RELATED []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod

[Term]
id: UBERON:0001052
name: rectum
def: "the terminal portion of the intestinal tube, terminating with the anus" []
synonym: "intestinum rectum" RELATED []
synonym: "rectal sac" RELATED []
synonym: "terminal portion of intestine" EXACT []
synonym: "terminal portion of large intestine" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0006866 ! terminal part of digestive tract
relationship: part_of UBERON:0012361 ! internal anal region

[Term]
id: UBERON:0001054
name: Malpighian tubule
def: "A tubule that extends from the posterior part of the digestive tract which absorbs solutes, water, and wastes from the surrounding hemolymph. Each tubule consists of a single layer of cells that is closed off at the distal end with the proximal end joining the alimentary canal at the junction between the midgut and hindgut[WP,modified]." []
synonym: "Malphigian tube" RELATED []
synonym: "tuba Malpighii" RELATED []
is_a: UBERON:0009773 ! renal tubule

[Term]
id: UBERON:0001062
name: anatomical entity
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." []

[Term]
id: UBERON:0001064
name: ventral pancreatic duct
def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." []
synonym: "canal of Wirsung" RELATED []
synonym: "chief pancreatic duct" EXACT []
synonym: "duct of Wirsung" EXACT []
synonym: "ductus pancreatis ventralis" RELATED []
synonym: "hepaticopancreatic duct" RELATED []
synonym: "main pancreatic duct" EXACT []
synonym: "pancreatic duct" BROAD []
is_a: UBERON:0007329 ! pancreatic duct
relationship: develops_from UBERON:0003924 ! ventral pancreatic bud
relationship: part_of UBERON:0000017 ! exocrine pancreas

[Term]
id: UBERON:0001066
name: intervertebral disk
def: "A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." []
synonym: "discus intervertebralis" EXACT []
synonym: "intervertebral disc" EXACT []
synonym: "intervertebral fibrocartilage" RELATED []
synonym: "spinal disc" EXACT []
synonym: "spinal disk" RELATED []
is_a: UBERON:0011135 ! intervertebral cartilage
intersection_of: UBERON:0011135 ! intervertebral cartilage
intersection_of: has_part UBERON:0002242 ! nucleus pulposus
relationship: has_part UBERON:0002242 ! nucleus pulposus

[Term]
id: UBERON:0001068
name: skin of back
def: "A zone of skin that is part of a back [Automatically generated definition]." []
synonym: "back skin" EXACT []
synonym: "back zone of skin" EXACT []
synonym: "skin, dorsal region" EXACT []
synonym: "zone of skin of back" EXACT []
is_a: UBERON:0001085 ! skin of trunk
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0011270 ! dorsal trunk

[Term]
id: UBERON:0001074
name: pericardial cavity
def: "A potential space between the visceral and parietal layers of the pericardium." []
synonym: "cavitas pericardiaca" RELATED []
synonym: "cavity of pericardial sac" EXACT []
synonym: "pericardial space" EXACT []
is_a: UBERON:0002323 ! coelemic cavity lumen
is_a: UBERON:0035809 ! serous cavity
relationship: develops_from UBERON:0003887 ! intraembryonic coelom
relationship: part_of UBERON:0002406 ! pericardial sac

[Term]
id: UBERON:0001081
name: endocardium of ventricle
def: "Endocardium that is part of the cardiac ventricle." []
synonym: "cardiac ventricle endocardium" EXACT []
synonym: "endocardium of cardiac ventricle" EXACT []
synonym: "endocardium of heart ventricle" EXACT []
synonym: "endocardium of lower chamber of heart" EXACT []
synonym: "endocardium of ventricle of heart" EXACT []
synonym: "heart ventricle endocardium" EXACT []
synonym: "lower chamber of heart endocardium" EXACT []
synonym: "ventricle endocardial tissue" RELATED []
synonym: "ventricle endocardium" EXACT []
synonym: "ventricle of heart endocardium" EXACT []
synonym: "ventricular endocardium" EXACT []
is_a: UBERON:0002165 ! endocardium
intersection_of: UBERON:0002165 ! endocardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0004784 ! heart ventricle wall

[Term]
id: UBERON:0001082
name: epicardium of ventricle
def: "An epicardial layer that lines a cardiac ventricle" []
synonym: "cardiac ventricle epicardium" EXACT []
synonym: "ventricular epicardium" EXACT []
is_a: UBERON:0002348 ! epicardium
intersection_of: UBERON:0002348 ! epicardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle

[Term]
id: UBERON:0001083
name: myocardium of ventricle
def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." []
synonym: "ventricle cardiac muscle" RELATED []
synonym: "ventricle myocardium" EXACT []
synonym: "ventricular myocardium" EXACT []
is_a: UBERON:0002349 ! myocardium
intersection_of: UBERON:0002349 ! myocardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0004784 ! heart ventricle wall

[Term]
id: UBERON:0001084
name: skin of head
def: "A zone of skin that is part of a head [Automatically generated definition]." []
synonym: "adult head zone of skin" EXACT []
synonym: "head skin" EXACT []
synonym: "head zone of skin" EXACT []
synonym: "zone of skin of adult head" EXACT []
synonym: "zone of skin of head" EXACT []
is_a: UBERON:0012180 ! head or neck skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0001085
name: skin of trunk
def: "A zone of skin that is part of a trunk [Automatically generated definition]." []
synonym: "torso zone of skin" EXACT []
synonym: "trunk skin" EXACT []
synonym: "trunk zone of skin" EXACT []
synonym: "zone of skin of torso" EXACT []
synonym: "zone of skin of trunk" EXACT []
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0001091
name: calcareous tooth
def: "Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food." []
synonym: "dental element" EXACT []
synonym: "dentine containing tooth" EXACT []
synonym: "tooth" EXACT []
synonym: "vertebrate tooth" EXACT []
is_a: UBERON:0003913 ! tooth-like structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005087 ! tooth placode
relationship: has_part UBERON:0001751 ! dentine

[Term]
id: UBERON:0001096
name: wall of esophagus
def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." []
synonym: "anatomical wall of esophagus" EXACT []
synonym: "anatomical wall of gullet" EXACT []
synonym: "anatomical wall of oesophagus" EXACT []
synonym: "esophageal wall" EXACT []
synonym: "esophagus anatomical wall" EXACT []
synonym: "esophagus wall" EXACT []
synonym: "gullet anatomical wall" EXACT []
synonym: "gullet wall" EXACT []
synonym: "oesophagus anatomical wall" EXACT []
synonym: "oesophagus wall" EXACT []
synonym: "wall of gullet" EXACT []
synonym: "wall of oesophagus" EXACT []
is_a: UBERON:0000328 ! gut wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0001118
name: lobe of thyroid gland
def: "A lobe of tissue that is part of a thyroid gland." []
synonym: "lobuli glandulae thyroideae" RELATED []
synonym: "lobus (glandula thyroidea)" EXACT []
synonym: "lobus glandulae thyroideae" EXACT []
synonym: "thyroid gland lobe" EXACT []
synonym: "thyroid lobe" EXACT []
is_a: UBERON:0009912 ! anatomical lobe
is_a: UBERON:0015212 ! lateral structure
is_a: UBERON:0035075 ! thymus subunit
intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0001130
name: vertebral column
def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." []
synonym: "backbone" NARROW []
synonym: "columna vertebralis" RELATED []
synonym: "dorsal spine" RELATED []
synonym: "spinal column" RELATED []
synonym: "spine" BROAD []
synonym: "vertebral column skeleton" NARROW []
synonym: "vertebral region" RELATED []
is_a: UBERON:0000075 ! subdivision of skeletal system
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0011138 ! post-cranial axial skeletal system

[Term]
id: UBERON:0001132
name: parathyroid gland
def: "The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism." []
synonym: "epithelial body" RELATED []
synonym: "parathyroid" EXACT []
synonym: "parathyroid secreting cell" RELATED []
is_a: UBERON:0002368 ! endocrine gland
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0001133
name: cardiac muscle tissue
def: "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." []
synonym: "cardiac muscle" EXACT []
synonym: "cardiac muscle muscle tissue" EXACT []
synonym: "cardiac muscle textus muscularis" EXACT []
synonym: "cardiac musculature" RELATED []
synonym: "heart muscle muscle tissue" EXACT []
synonym: "heart muscle textus muscularis" EXACT []
synonym: "heart myocardium muscle tissue" EXACT []
synonym: "heart myocardium textus muscularis" EXACT []
synonym: "muscle of heart muscle tissue" EXACT []
synonym: "muscle of heart textus muscularis" EXACT []
synonym: "muscle tissue of cardiac muscle" EXACT []
synonym: "muscle tissue of heart muscle" EXACT []
synonym: "muscle tissue of heart myocardium" EXACT []
synonym: "muscle tissue of muscle of heart" EXACT []
synonym: "muscle tissue of myocardium" EXACT []
synonym: "myocardium muscle tissue" EXACT []
synonym: "myocardium textus muscularis" EXACT []
synonym: "textus muscularis of cardiac muscle" EXACT []
synonym: "textus muscularis of heart muscle" EXACT []
synonym: "textus muscularis of heart myocardium" EXACT []
synonym: "textus muscularis of muscle of heart" EXACT []
synonym: "textus muscularis of myocardium" EXACT []
is_a: UBERON:0002036 ! striated muscle tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
disjoint_from: UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0001134
name: skeletal muscle tissue
def: "Muscle tissue that consists primarily of skeletal muscle fibers." []
synonym: "skeletal muscle" BROAD []
synonym: "skeletal muscle system" RELATED []
synonym: "somatic muscle" RELATED []
is_a: UBERON:0002036 ! striated muscle tissue
relationship: develops_from UBERON:0003082 ! myotome
relationship: part_of UBERON:0014892 ! skeletal muscle organ

[Term]
id: UBERON:0001135
name: smooth muscle tissue
def: "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." []
synonym: "involuntary muscle" EXACT []
synonym: "non-striated muscle" EXACT []
synonym: "smooth muscle" EXACT []
synonym: "textus muscularis levis; textus muscularis nonstriatus" RELATED []
synonym: "textus muscularis nonstriatus" EXACT []
synonym: "visceral muscle" NARROW []
synonym: "visceral muscle tissue" NARROW []
is_a: UBERON:0002385 ! muscle tissue
disjoint_from: UBERON:0002036 ! striated muscle tissue

[Term]
id: UBERON:0001136
name: mesothelium
def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." []
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000487 ! simple squamous epithelium
intersection_of: develops_from UBERON:0000926 ! mesoderm
intersection_of: part_of UBERON:0000042 ! serous membrane
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0000042 ! serous membrane

[Term]
id: UBERON:0001137
name: dorsum
def: "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." []
synonym: "back" EXACT []
synonym: "back of body proper" EXACT []
synonym: "dorsal part of organism" EXACT []
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0001140
name: renal vein
def: "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." []
synonym: "kidney vein" EXACT []
synonym: "renal venous tree" EXACT []
synonym: "vein of kidney" EXACT []
synonym: "venae renales" RELATED []
is_a: UBERON:0001638 ! vein

[Term]
id: UBERON:0001152
name: cystic duct
def: "the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" []
synonym: "ductus cysticus" RELATED []
is_a: UBERON:0003703 ! extrahepatic bile duct
disjoint_from: UBERON:0005171 ! hepatic duct
relationship: develops_from UBERON:0005604 ! extrahepatic part of hepatic duct
relationship: part_of UBERON:0001173 ! biliary tree

[Term]
id: UBERON:0001153
name: caecum
def: "A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction." []
synonym: "blind intestine" RELATED []
synonym: "blindgut" RELATED []
synonym: "caeca" NARROW []
synonym: "caecum" EXACT []
synonym: "ceca" NARROW []
synonym: "cecum" EXACT []
synonym: "intestinum caecum" RELATED []
synonym: "intestinum crassum caecum" EXACT []
synonym: "intestinum crassum cecum" RELATED []
is_a: UBERON:0000168 ! proximal-distal subdivision of colon
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0001045 ! midgut
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0001154
name: vermiform appendix
def: "A blind-ended tube connected to the cecum, from which it develops embryologically[WP]." []
synonym: "apex of caecum" RELATED []
synonym: "apex of cecum" RELATED []
synonym: "appendix" EXACT []
synonym: "appendix vermiformis" EXACT []
synonym: "appendix vermiformis" RELATED []
synonym: "caecal appendix" EXACT []
synonym: "cecal appendix" EXACT []
synonym: "vermix" BROAD []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0013765 ! digestive system element
relationship: develops_from UBERON:0001045 ! midgut
relationship: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0004907 ! lower digestive tract

[Term]
id: UBERON:0001155
name: colon
def: "Last portion of the large intestine before it becomes the rectum." []
synonym: "hindgut" RELATED []
synonym: "large bowel" EXACT []
synonym: "posterior intestine" NARROW []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of UBERON:0000059 ! large intestine

[Term]
id: UBERON:0001156
name: ascending colon
def: "Section of colon which is distal to the cecum and proximal to the transversecolon.[FMA,modified]" []
synonym: "colon ascendens" EXACT []
synonym: "spiral colon" RELATED []
is_a: UBERON:0000168 ! proximal-distal subdivision of colon
relationship: develops_from UBERON:0001045 ! midgut

[Term]
id: UBERON:0001157
name: transverse colon
def: "The proximal-distal subdivision of colon that runs transversely across the upper part of the abdomen, from the right to the left colic flexure. Continuous with the descending colon[BTO,modified]." []
synonym: "colon transversum" EXACT []
is_a: UBERON:0000168 ! proximal-distal subdivision of colon
relationship: develops_from UBERON:0001045 ! midgut

[Term]
id: UBERON:0001158
name: descending colon
def: "The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon." []
synonym: "colon descendens" EXACT []
is_a: UBERON:0000168 ! proximal-distal subdivision of colon
relationship: develops_from UBERON:0001046 ! hindgut

[Term]
id: UBERON:0001159
name: sigmoid colon
def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." []
synonym: "colon sigmoideum" RELATED []
synonym: "pelvic colon" RELATED []
synonym: "sigmoid colon" RELATED []
synonym: "sigmoid flexure" RELATED []
is_a: UBERON:0000168 ! proximal-distal subdivision of colon
relationship: develops_from UBERON:0001046 ! hindgut

[Term]
id: UBERON:0001160
name: fundus of stomach
def: "The fundus is the portion of the stomach that lies above the cardiac notch, and contains the fundic glands[GO, Kardong]." []
synonym: "fundus gastricus" RELATED []
synonym: "fundus gastricus (ventricularis)" EXACT []
synonym: "fundus gastricus ventricularis" RELATED []
synonym: "fundus ventricularis" RELATED []
synonym: "fundus ventriculi" RELATED []
synonym: "gastric fundus" EXACT []
synonym: "stomach fundus" EXACT []
is_a: UBERON:0009870 ! zone of stomach
relationship: has_part UBERON:0010038 ! fundic gastric gland

[Term]
id: UBERON:0001162
name: cardia of stomach
def: "The part of the stomach attached to the esophagus. The cardia begins immediately distal to the z-line of the gastroeosphageal junction, where the squamous epithelium of the esophagus gives way to the columnar epithelium of the gastrointestinal tract[WP]" []
synonym: "antrum cardiacum" RELATED []
synonym: "cardiac antrum" RELATED []
synonym: "cardiac orifice" RELATED []
synonym: "cardiac region" RELATED []
synonym: "cardial orifice" RELATED []
synonym: "cardial part of stomach" EXACT []
synonym: "gastric cardia" EXACT []
synonym: "pars cardiaca (gaster)" EXACT []
synonym: "pars cardiaca gastricae" EXACT []
synonym: "stomach cardiac region" EXACT []
is_a: UBERON:0009870 ! zone of stomach
intersection_of: UBERON:0009870 ! zone of stomach
intersection_of: has_part UBERON:0008859 ! cardiac gastric gland
relationship: has_part UBERON:0008859 ! cardiac gastric gland

[Term]
id: UBERON:0001165
name: pyloric antrum
def: "the area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells" []
synonym: "antrum" BROAD []
synonym: "antrum of stomach" EXACT []
synonym: "antrum of Willis" RELATED []
synonym: "antrum pylori" RELATED []
synonym: "antrum pyloricum" RELATED []
synonym: "gastric antrum" RELATED []
synonym: "stomach antrum" RELATED []
synonym: "stomach pyloric antrum" EXACT []
is_a: UBERON:0009870 ! zone of stomach
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0001166
name: pylorus
def: "the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" []
synonym: "pars pylorica" EXACT []
synonym: "pars pylorica gastricae" EXACT []
synonym: "pyloric part of stomach" EXACT []
synonym: "pyloric region" EXACT []
synonym: "stomach pyloric region" EXACT []
synonym: "valvula pylori" RELATED []
is_a: UBERON:0009870 ! zone of stomach
intersection_of: UBERON:0009870 ! zone of stomach
intersection_of: has_part UBERON:0001165 ! pyloric antrum
intersection_of: has_part UBERON:0008858 ! pyloric canal
intersection_of: has_part UBERON:0008861 ! pyloric gastric gland
relationship: has_part UBERON:0001165 ! pyloric antrum
relationship: has_part UBERON:0008858 ! pyloric canal
relationship: has_part UBERON:0008861 ! pyloric gastric gland

[Term]
id: UBERON:0001167
name: wall of stomach
def: "the layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between" []
synonym: "anatomical wall of stomach" EXACT []
synonym: "anatomical wall of ventriculus" EXACT []
synonym: "gastric wall" EXACT []
synonym: "stomach anatomical wall" EXACT []
synonym: "stomach wall" EXACT []
synonym: "ventriculus anatomical wall" EXACT []
synonym: "ventriculus wall" EXACT []
synonym: "wall of ventriculus" EXACT []
is_a: UBERON:0000328 ! gut wall
is_a: UBERON:0009034 ! stomach region
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: UBERON:0001168
name: wall of small intestine
def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." []
synonym: "anatomical wall of small bowel" EXACT []
synonym: "anatomical wall of small intestine" EXACT []
synonym: "small bowel anatomical wall" EXACT []
synonym: "small bowel wall" EXACT []
synonym: "small intestinal wall" EXACT []
synonym: "small intestine anatomical wall" EXACT []
synonym: "small intestine wall" EXACT []
synonym: "wall of small bowel" EXACT []
is_a: UBERON:0001262 ! wall of intestine
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001169
name: wall of large intestine
def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." []
synonym: "anatomical wall of large intestine" EXACT []
synonym: "large intestinal wall" EXACT []
synonym: "large intestine anatomical wall" EXACT []
synonym: "large intestine wall" EXACT []
is_a: UBERON:0001262 ! wall of intestine
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine

[Term]
id: UBERON:0001170
name: mesentery of small intestine
def: "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." []
synonym: "mesentery (proper)" EXACT []
synonym: "mesentery proper" EXACT []
synonym: "small intestinal mesentery" EXACT []
synonym: "small intestine mesentery" EXACT []
is_a: UBERON:0001206 ! serosa of small intestine
is_a: UBERON:0004854 ! gastrointestinal system mesentery
is_a: UBERON:0007826 ! peritoneal mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001171
name: portal lobule
def: "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0009911 ! lobule
relationship: part_of UBERON:0001280 ! liver parenchyma

[Term]
id: UBERON:0001172
name: hepatic acinus
def: "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." []
synonym: "liver acinus" EXACT []
synonym: "portal acinus" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011858 ! acinus of exocrine gland
relationship: part_of UBERON:0001280 ! liver parenchyma

[Term]
id: UBERON:0001173
name: biliary tree
def: "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." []
synonym: "biliary tract" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0013765 ! digestive system element
relationship: develops_from UBERON:0004912 ! biliary bud
relationship: has_part UBERON:0001246 ! interlobular bile duct
relationship: has_part UBERON:0001282 ! intralobular bile duct
relationship: has_part UBERON:0003703 ! extrahepatic bile duct
relationship: part_of UBERON:0002294 ! biliary system

[Term]
id: UBERON:0001178
name: visceral peritoneum
def: "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." []
synonym: "visceral serous membrane of peritoneum" EXACT []
is_a: UBERON:0022350 ! visceral serous membrane
intersection_of: UBERON:0022350 ! visceral serous membrane
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum

[Term]
id: UBERON:0001179
name: peritoneal cavity
def: "Anatomical cavity bounded by visceral and parietal peritoneum" []
synonym: "cavitas peritonealis" RELATED []
synonym: "saccus serosus peritonei" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0035809 ! serous cavity
relationship: develops_from UBERON:0003887 ! intraembryonic coelom
relationship: part_of UBERON:0035820 ! peritoneal sac

[Term]
id: UBERON:0001193
name: hepatic artery
def: "An artery that supplies the liver." []
synonym: "arteria hepatica" RELATED []
synonym: "arteria hepatica propria" EXACT []
is_a: UBERON:0001637 ! artery

[Term]
id: UBERON:0001199
name: mucosa of stomach
def: "The mucosal layer that lines the stomach." []
synonym: "gastric mucosa" EXACT []
synonym: "gastric mucous membrane" EXACT []
synonym: "Magenschleimhaut" RELATED []
synonym: "mucosa of organ of stomach" EXACT []
synonym: "mucosa of organ of ventriculus" EXACT []
synonym: "mucosa of ventriculus" EXACT []
synonym: "mucous membrane of stomach" EXACT []
synonym: "mucous membrane of ventriculus" EXACT []
synonym: "organ mucosa of stomach" EXACT []
synonym: "organ mucosa of ventriculus" EXACT []
synonym: "stomach mucosa" EXACT []
synonym: "stomach mucosa of organ" EXACT []
synonym: "stomach mucous membrane" EXACT []
synonym: "stomach organ mucosa" EXACT []
synonym: "tunica mucosa (gaster)" EXACT []
synonym: "tunica mucosa gastricae" EXACT []
synonym: "tunica mucosa gastris" RELATED []
synonym: "ventriculus mucosa" EXACT []
synonym: "ventriculus mucosa of organ" EXACT []
synonym: "ventriculus mucous membrane" EXACT []
synonym: "ventriculus organ mucosa" EXACT []
is_a: UBERON:0004786 ! gastrointestinal system mucosa
is_a: UBERON:0009034 ! stomach region
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0001167 ! wall of stomach

[Term]
id: UBERON:0001200
name: submucosa of stomach
def: "the fibrous connective tissue layer beneath the stomach mucosa" []
synonym: "gastric submucosa" EXACT []
synonym: "stomach submucosa" EXACT []
synonym: "submucosa of ventriculus" EXACT []
synonym: "submucous layer of stomach" RELATED []
synonym: "tela submucosa (gaster)" EXACT []
synonym: "tela submucosa gastricae" EXACT []
synonym: "tela submucosa ventriculi" RELATED []
synonym: "ventriculus submucosa" EXACT []
is_a: UBERON:0009034 ! stomach region
is_a: UBERON:0018257 ! submucosa of digestive tract
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0001167 ! wall of stomach

[Term]
id: UBERON:0001201
name: serosa of stomach
def: "the outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum" []
synonym: "anatomical wall of stomach serosa" EXACT []
synonym: "anatomical wall of stomach serous membrane" EXACT []
synonym: "anatomical wall of ventriculus serosa" EXACT []
synonym: "anatomical wall of ventriculus serous membrane" EXACT []
synonym: "gastric serosa" RELATED []
synonym: "gastric wall serosa" EXACT []
synonym: "gastric wall serous membrane" EXACT []
synonym: "serosa of anatomical wall of stomach" EXACT []
synonym: "serosa of anatomical wall of ventriculus" EXACT []
synonym: "serosa of gastric wall" EXACT []
synonym: "serosa of stomach anatomical wall" EXACT []
synonym: "serosa of stomach wall" EXACT []
synonym: "serosa of ventriculus anatomical wall" EXACT []
synonym: "serosa of ventriculus wall" EXACT []
synonym: "serosa of wall of stomach" EXACT []
synonym: "serosa of wall of ventriculus" EXACT []
synonym: "serous coat of stomach" EXACT []
synonym: "serous membrane of anatomical wall of stomach" EXACT []
synonym: "serous membrane of anatomical wall of ventriculus" EXACT []
synonym: "serous membrane of gastric wall" EXACT []
synonym: "serous membrane of stomach anatomical wall" EXACT []
synonym: "serous membrane of stomach wall" EXACT []
synonym: "serous membrane of ventriculus anatomical wall" EXACT []
synonym: "serous membrane of ventriculus wall" EXACT []
synonym: "serous membrane of wall of stomach" EXACT []
synonym: "serous membrane of wall of ventriculus" EXACT []
synonym: "stomach anatomical wall serosa" EXACT []
synonym: "stomach anatomical wall serous membrane" EXACT []
synonym: "stomach serosa" EXACT []
synonym: "stomach wall serosa" EXACT []
synonym: "stomach wall serous membrane" EXACT []
synonym: "tunica serosa (gaster)" EXACT []
synonym: "tunica serosa gastricae" EXACT []
synonym: "ventriculus anatomical wall serosa" EXACT []
synonym: "ventriculus anatomical wall serous membrane" EXACT []
synonym: "ventriculus wall serosa" EXACT []
synonym: "ventriculus wall serous membrane" EXACT []
synonym: "visceral peritoneum of stomach" EXACT []
synonym: "wall of stomach serosa" EXACT []
synonym: "wall of stomach serous membrane" EXACT []
synonym: "wall of ventriculus serosa" EXACT []
synonym: "wall of ventriculus serous membrane" EXACT []
is_a: UBERON:0004782 ! gastrointestinal system serosa
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001167 ! wall of stomach
relationship: part_of UBERON:0001167 ! wall of stomach

[Term]
id: UBERON:0001202
name: pyloric sphincter
def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." []
synonym: "pyloric valve" EXACT []
is_a: UBERON:0011185 ! gastrointestinal sphincter
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0001204
name: mucosa of small intestine
def: "A mucosa that is part of a small intestine [Automatically generated definition]." []
synonym: "mucosa of organ of small bowel" EXACT []
synonym: "mucosa of organ of small intestine" EXACT []
synonym: "mucosa of small bowel" EXACT []
synonym: "mucous membrane of small bowel" EXACT []
synonym: "mucous membrane of small intestine" EXACT []
synonym: "organ mucosa of small bowel" EXACT []
synonym: "organ mucosa of small intestine" EXACT []
synonym: "small bowel mucosa" EXACT []
synonym: "small bowel mucosa of organ" EXACT []
synonym: "small bowel mucous membrane" EXACT []
synonym: "small bowel organ mucosa" EXACT []
synonym: "small intestinal mucosa" EXACT []
synonym: "small intestine mucosa" EXACT []
synonym: "small intestine mucosa of organ" EXACT []
synonym: "small intestine mucous membrane" EXACT []
synonym: "small intestine organ mucosa" EXACT []
synonym: "tunica mucosa (intestinum tenue)" EXACT []
synonym: "tunica mucosa intestini tenuis" EXACT []
is_a: UBERON:0001242 ! intestinal mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0001242 ! intestinal mucosa
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001205
name: submucosa of small intestine
def: "submucosal tissue in the small intestines." []
synonym: "small bowel submucosa" EXACT []
synonym: "small intestinal submucosa" EXACT []
synonym: "small intestine submucosa" EXACT []
synonym: "submucosa of small bowel" EXACT []
synonym: "tela submucosa (intestinum tenue)" EXACT []
synonym: "tela submucosa intestini tenuis" EXACT []
is_a: UBERON:0009566 ! intestinal submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001206
name: serosa of small intestine
def: "A serous membrane that is part of a small intestine [Automatically generated definition]." []
synonym: "serosa of small bowel" EXACT []
synonym: "serous coat of small intestine" EXACT []
synonym: "serous membrane of small bowel" EXACT []
synonym: "serous membrane of small intestine" EXACT []
synonym: "small bowel serosa" EXACT []
synonym: "small bowel serous membrane" EXACT []
synonym: "small intestinal serosa" EXACT []
synonym: "small intestine serosa" EXACT []
synonym: "small intestine serous membrane" EXACT []
synonym: "tunica serosa (intestinum tenue)" EXACT []
synonym: "tunica serosa intestini tenuis" EXACT []
synonym: "visceral peritoneum of small intestine" EXACT []
is_a: UBERON:0001243 ! serosa of intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0001243 ! serosa of intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001207
name: mucosa of large intestine
def: "A mucosa that is part of a large intestine [Automatically generated definition]." []
synonym: "large intestinal mucosa" EXACT []
synonym: "large intestine mucosa" EXACT []
synonym: "large intestine mucosa of organ" EXACT []
synonym: "large intestine mucous membrane" EXACT []
synonym: "large intestine organ mucosa" EXACT []
synonym: "mucosa of organ of large intestine" EXACT []
synonym: "mucous membrane of large intestine" EXACT []
synonym: "organ mucosa of large intestine" EXACT []
synonym: "tunica mucosa intestini crassi" EXACT []
is_a: UBERON:0001242 ! intestinal mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: UBERON:0001208
name: submucosa of large intestine
def: "A submucosa that is part of a large intestine [Automatically generated definition]." []
synonym: "large intestinal submucosa" EXACT []
synonym: "large intestine submucosa" EXACT []
synonym: "submucous layer of large intestine" RELATED []
synonym: "tela submucosa intestini crassi" EXACT []
is_a: UBERON:0009566 ! intestinal submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine

[Term]
id: UBERON:0001209
name: serosa of large intestine
def: "A serous membrane that is part of a large intestine [Automatically generated definition]." []
synonym: "large intestinal serosa" EXACT []
synonym: "large intestine serosa" EXACT []
synonym: "large intestine serous membrane" EXACT []
synonym: "serous coat of large intestine" EXACT []
synonym: "serous membrane of large intestine" EXACT []
synonym: "tunica serosa intestini crassi" EXACT []
synonym: "visceral peritoneum of large intestine" EXACT []
is_a: UBERON:0001243 ! serosa of intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine
relationship: part_of UBERON:0001243 ! serosa of intestine

[Term]
id: UBERON:0001211
name: Peyer's patch
def: "the protruding lymphoid tissue located on the mucosa of the intestine that is composed of densely packed B cell follicles" []
synonym: "aggregated lymphoid follicle of intestine" RELATED []
synonym: "aggregated lymphoid nodule" RELATED []
synonym: "noduli lymphoidei aggregati" EXACT []
synonym: "Peyers gland" RELATED []
synonym: "Peyers patch" RELATED []
is_a: UBERON:0001962 ! gut-associated lymphoid tissue
relationship: part_of UBERON:0000030 ! lamina propria
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: UBERON:0001212
name: duodenal gland
def: "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." []
synonym: "Brunner's gland" EXACT []
synonym: "gland of Brunner" EXACT []
synonym: "glandula duodenales" RELATED []
synonym: "glandula duodenales Brunneri" RELATED []
synonym: "submucosal gland of duodenum" EXACT []
is_a: UBERON:0003408 ! gland of gut
is_a: UBERON:0011148 ! submucosal gland
intersection_of: UBERON:0011148 ! submucosal gland
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0001213
name: intestinal villus
def: "the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" []
synonym: "enteric villi" EXACT []
synonym: "enteric villous" EXACT []
synonym: "enteric villus" EXACT []
synonym: "intestinal villi" EXACT []
synonym: "intestinal villus layer" RELATED []
synonym: "small intestine villus" RELATED []
synonym: "villi intestinales" EXACT []
synonym: "villi intestinales" RELATED []
synonym: "villus" EXACT []
synonym: "villus intestinalis (intestinum tenue)" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0004923 ! organ component layer
relationship: has_part UBERON:0001981 ! blood vessel
relationship: has_part UBERON:0012425 ! striated border microvillus layer
relationship: part_of UBERON:0001277 ! intestinal epithelium

[Term]
id: UBERON:0001224
name: renal pelvis
def: "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." []
synonym: "kidney pelvis" EXACT []
synonym: "p. renallis" RELATED []
synonym: "pelvis of ureter" EXACT []
synonym: "pyelum" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
disjoint_from: UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0001225
name: cortex of kidney
def: "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." []
synonym: "cortex renalis" EXACT []
synonym: "kidney cortex" EXACT []
synonym: "renal cortex" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0001851 ! cortex
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0008987 ! renal parenchyma

[Term]
id: UBERON:0001228
name: renal papilla
def: "Tip of renal pyramid projecting into a minor calyx." []
synonym: "kidney papilla" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001294 ! inner medulla of kidney

[Term]
id: UBERON:0001229
name: renal corpuscle
def: "the structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron" []
synonym: "corpusculum renale" EXACT []
synonym: "corpusculum renis" RELATED []
synonym: "cortical renal corpuscle" RELATED []
synonym: "kidney corpuscle" RELATED []
synonym: "malphighian corpuscle" RELATED []
synonym: "malphigian corpuscle" EXACT []
synonym: "Malpighian corpuscle" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000063 ! organ subunit
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0007684 ! uriniferous tubule

[Term]
id: UBERON:0001230
name: glomerular capsule
def: "A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus" []
synonym: "Bowman's capsule" EXACT []
synonym: "bowman's capsule" RELATED []
synonym: "Bowmans capsule" EXACT []
synonym: "capsula glomerularis" EXACT []
synonym: "capsula glomeruli" RELATED []
synonym: "malphigian capsule" RELATED []
synonym: "Mueller capsule" RELATED []
synonym: "Muellerian capsule" RELATED []
synonym: "pronephric glomerular capsule" RELATED []
synonym: "renal glomerular capsule" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: develops_from UBERON:0004199 ! S-shaped body
relationship: part_of UBERON:0001229 ! renal corpuscle

[Term]
id: UBERON:0001231
name: nephron tubule
def: "An epithelial tube that is part of the nephron, the functional part of the kidney." []
synonym: "kidney tubule" EXACT []
synonym: "renal tubule" BROAD []
synonym: "tubulus renalis" EXACT []
synonym: "uriniferous tubule" RELATED []
is_a: UBERON:0004211 ! nephron epithelium
is_a: UBERON:0009773 ! renal tubule
intersection_of: UBERON:0003914 ! epithelial tube
intersection_of: part_of UBERON:0001285 ! nephron
relationship: develops_from UBERON:0003918 ! kidney mesenchyme
relationship: part_of UBERON:0001285 ! nephron

[Term]
id: UBERON:0001232
name: collecting duct of renal tubule
def: "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient" []
synonym: "arcuate renal tubule" RELATED []
synonym: "collecting duct" EXACT []
synonym: "collecting duct system" RELATED []
synonym: "collecting tubule" RELATED []
synonym: "junctional tube" RELATED []
synonym: "kidney collecting duct" EXACT []
synonym: "kidney collecting tubule" RELATED []
synonym: "renal collecting tubule" EXACT []
synonym: "tubulus renalis arcuatus" EXACT []
synonym: "tubulus renalis colligens" EXACT []
synonym: "ureteric tree" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0006555 ! excretory tube
relationship: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0007684 ! uriniferous tubule

[Term]
id: UBERON:0001235
name: adrenal cortex
def: "the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" []
synonym: "adrenal gland cortex" EXACT []
synonym: "cortex (glandula suprarenalis)" EXACT []
synonym: "cortex glandulae suprarenalis" RELATED []
synonym: "cortex of adrenal gland" EXACT []
synonym: "cortex of suprarenal gland" EXACT []
synonym: "suprarenal" RELATED []
synonym: "suprarenal cortex" EXACT []
is_a: UBERON:0001851 ! cortex
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0002369 ! adrenal gland
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0002369 ! adrenal gland

[Term]
id: UBERON:0001236
name: adrenal medulla
def: "the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" []
synonym: "adrenal central medulla" RELATED []
synonym: "adrenal gland medulla" EXACT []
synonym: "chromaffin cells" RELATED []
synonym: "medulla (glandula suprarenalis)" EXACT []
synonym: "medulla glandulae suprarenalis" EXACT []
synonym: "medulla of adrenal gland" EXACT []
synonym: "medulla of glandula suprarenalis" RELATED []
synonym: "medulla of suprarenal gland" EXACT []
synonym: "suprarenal medulla" EXACT []
is_a: UBERON:0000958 ! medulla of organ
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0002369 ! adrenal gland
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0002369 ! adrenal gland

[Term]
id: UBERON:0001237
name: paraaortic body
def: "A chromaffin paraganglion located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery." []
synonym: "organ of Zuckerkandl" EXACT []
synonym: "para-aortic body" RELATED []
synonym: "paraganglia of zuckerkandl" RELATED []
synonym: "paraganglion of Zuckerkandl" EXACT []
is_a: UBERON:0012279 ! chromaffin paraganglion

[Term]
id: UBERON:0001238
name: lamina propria of small intestine
def: "Lamina propria that is part_of the small intestine." []
synonym: "lamina propria mucosa of small bowel" EXACT []
synonym: "lamina propria mucosa of small intestine" EXACT []
synonym: "lamina propria mucosae of small bowel" EXACT []
synonym: "lamina propria mucosae of small intestine" EXACT []
synonym: "lamina propria of mucosa of small intestine" EXACT []
synonym: "lamina propria of small bowel" EXACT []
synonym: "small bowel lamina propria" EXACT []
synonym: "small bowel lamina propria mucosa" EXACT []
synonym: "small bowel lamina propria mucosae" EXACT []
synonym: "small intestine lamina propria" EXACT []
synonym: "small intestine lamina propria mucosa" EXACT []
synonym: "small intestine lamina propria mucosae" EXACT []
is_a: UBERON:0004780 ! gastrointestinal system lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0001204 ! mucosa of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001241
name: crypt of Lieberkuhn of small intestine
def: "the tubular intestinal glands found in the mucosal membranes of the small intestine" []
synonym: "crypt of lieberkuhn of small bowel" EXACT []
synonym: "crypt of lieberkuhn of small intestine" EXACT []
synonym: "intestinal gland of small bowel" EXACT []
synonym: "intestinal gland of small intestine" EXACT []
synonym: "lieberkuhn crypt of small bowel" EXACT []
synonym: "lieberkuhn crypt of small intestine" EXACT []
synonym: "small bowel crypt of lieberkuhn" EXACT []
synonym: "small bowel intestinal gland" EXACT []
synonym: "small bowel lieberkuhn crypt" EXACT []
synonym: "small intestinal crypt of Lieberkuhn" EXACT []
synonym: "small intestine crypt of Lieberkuhn" EXACT []
synonym: "small intestine crypt of lieberkuhn" EXACT []
synonym: "small intestine intestinal gland" EXACT []
synonym: "small intestine lieberkuhn crypt" EXACT []
is_a: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001242
name: intestinal mucosa
def: "The innermost membrane of the four coats of the intestinal wall, the other three being the submucosa, muscular layers, and serosa. (Berk et al., Gastroenterology, 4th ed, v.3, p1479)" []
synonym: "bowel mucosa" EXACT []
synonym: "bowel mucosa of organ" EXACT []
synonym: "bowel mucous membrane" EXACT []
synonym: "bowel organ mucosa" EXACT []
synonym: "intestine mucosa" EXACT []
synonym: "intestine mucosa of organ" EXACT []
synonym: "intestine mucous membrane" EXACT []
synonym: "intestine organ mucosa" EXACT []
synonym: "mucosa of bowel" EXACT []
synonym: "mucosa of intestine" EXACT []
synonym: "mucosa of organ of bowel" EXACT []
synonym: "mucosa of organ of intestine" EXACT []
synonym: "mucous membrane of bowel" EXACT []
synonym: "mucous membrane of intestine" EXACT []
synonym: "organ mucosa of bowel" EXACT []
synonym: "organ mucosa of intestine" EXACT []
synonym: "tunica mucosa intestini" EXACT []
is_a: UBERON:0004786 ! gastrointestinal system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 ! wall of intestine

[Term]
id: UBERON:0001243
name: serosa of intestine
def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." []
synonym: "anatomical wall of bowel serosa" EXACT []
synonym: "anatomical wall of bowel serous membrane" EXACT []
synonym: "anatomical wall of intestine serosa" EXACT []
synonym: "anatomical wall of intestine serous membrane" EXACT []
synonym: "bowel anatomical wall serosa" EXACT []
synonym: "bowel anatomical wall serous membrane" EXACT []
synonym: "bowel wall serosa" EXACT []
synonym: "bowel wall serous membrane" EXACT []
synonym: "intestinal serosa" EXACT []
synonym: "intestinal wall serosa" EXACT []
synonym: "intestinal wall serous membrane" EXACT []
synonym: "intestine anatomical wall serosa" EXACT []
synonym: "intestine anatomical wall serous membrane" EXACT []
synonym: "intestine serosa" EXACT []
synonym: "intestine wall serosa" EXACT []
synonym: "intestine wall serous membrane" EXACT []
synonym: "serosa of anatomical wall of bowel" EXACT []
synonym: "serosa of anatomical wall of intestine" EXACT []
synonym: "serosa of bowel anatomical wall" EXACT []
synonym: "serosa of bowel wall" EXACT []
synonym: "serosa of intestinal wall" EXACT []
synonym: "serosa of intestine anatomical wall" EXACT []
synonym: "serosa of intestine wall" EXACT []
synonym: "serosa of wall of bowel" EXACT []
synonym: "serosa of wall of intestine" EXACT []
synonym: "serous membrane of anatomical wall of bowel" EXACT []
synonym: "serous membrane of anatomical wall of intestine" EXACT []
synonym: "serous membrane of bowel anatomical wall" EXACT []
synonym: "serous membrane of bowel wall" EXACT []
synonym: "serous membrane of intestinal wall" EXACT []
synonym: "serous membrane of intestine anatomical wall" EXACT []
synonym: "serous membrane of intestine wall" EXACT []
synonym: "serous membrane of wall of bowel" EXACT []
synonym: "serous membrane of wall of intestine" EXACT []
synonym: "visceral peritoneum of intestine" EXACT []
synonym: "wall of bowel serosa" EXACT []
synonym: "wall of bowel serous membrane" EXACT []
synonym: "wall of intestine serosa" EXACT []
synonym: "wall of intestine serous membrane" EXACT []
is_a: UBERON:0004782 ! gastrointestinal system serosa
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 ! wall of intestine

[Term]
id: UBERON:0001246
name: interlobular bile duct
def: "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." []
synonym: "interlobular ductule" EXACT []
is_a: UBERON:0003704 ! intrahepatic bile duct
relationship: part_of UBERON:0001279 ! portal triad

[Term]
id: UBERON:0001249
name: spleen lymphoid follicle
def: "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" []
synonym: "lymphatic follicle of spleen" EXACT []
synonym: "lymphoid follicle of spleen" EXACT []
synonym: "lymphoid nodule of spleen" EXACT []
synonym: "Malpighian body" EXACT []
synonym: "spleen B cell follicle" EXACT []
synonym: "spleen lymphoid follicle" EXACT []
synonym: "spleen lymphoid nodule" RELATED []
synonym: "splenic B cell follicle" EXACT []
synonym: "splenic lymphatic follicle" EXACT []
synonym: "splenic lymphoid follicle" EXACT []
is_a: UBERON:0000444 ! lymphoid follicle
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000444 ! lymphoid follicle
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0001959 ! white pulp of spleen
relationship: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0006561 ! non-lymphatic part of lymphoid system
relationship: part_of UBERON:1000024 ! parenchyma of spleen

[Term]
id: UBERON:0001250
name: red pulp of spleen
def: "the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" []
synonym: "pulpa rubra" EXACT []
synonym: "pulpa splenica" RELATED []
synonym: "red pulp" EXACT []
synonym: "spleen red pulp" EXACT []
synonym: "splenic red pulp" EXACT []
is_a: UBERON:1000023 ! spleen pulp

[Term]
id: UBERON:0001251
name: marginal zone of spleen
def: "the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" []
synonym: "junctional zone of spleen" EXACT []
synonym: "marginal zone" BROAD []
synonym: "spleen marginal zone" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0001252
name: adventitia of ureter
def: "An adventitia that is part of a ureter." []
synonym: "external adventitia of ureter" EXACT []
synonym: "tunica adventitia (Ureter)" EXACT []
synonym: "tunica adventitia ureteris" EXACT []
synonym: "ureter adventitia" EXACT []
synonym: "ureteral adventitia" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005742 ! adventitia
intersection_of: UBERON:0005742 ! adventitia
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0009916 ! wall of ureter

[Term]
id: UBERON:0001253
name: lamina propria of ureter
def: "A lamina propria that is part of a ureter [Automatically generated definition]." []
synonym: "lamina propria mucosa of ureter" EXACT []
synonym: "lamina propria mucosae of ureter" EXACT []
synonym: "ureter lamina propria" EXACT []
synonym: "ureter lamina propria mucosa" EXACT []
synonym: "ureter lamina propria mucosae" EXACT []
is_a: UBERON:0000030 ! lamina propria
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0004980 ! mucosa of ureter
relationship: part_of UBERON:0009916 ! wall of ureter

[Term]
id: UBERON:0001254
name: urothelium of ureter
def: "The luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder[MP]" []
synonym: "transitional epithelium of ureter" EXACT []
synonym: "ureter luminal urothelium" RELATED []
synonym: "ureter transitional epithelium" EXACT []
synonym: "ureter urothelium" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000365 ! urothelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000365 ! urothelium
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter

[Term]
id: UBERON:0001255
name: urinary bladder
def: "distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." []
synonym: "bladder" BROAD []
synonym: "urocyst" RELATED []
synonym: "vesica" RELATED []
synonym: "vesica urinaria" EXACT []
is_a: UBERON:0002075 ! viscus
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0018707 ! bladder organ
relationship: develops_from UBERON:0000164 ! primitive urogenital sinus
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: UBERON:0001256
name: wall of urinary bladder
def: "An anatomical wall that lines the insider of a urinary bladder." []
synonym: "anatomical wall of bladder" EXACT []
synonym: "anatomical wall of urinary bladder" EXACT []
synonym: "bladder anatomical wall" EXACT []
synonym: "bladder wall" EXACT []
synonym: "urinary bladder anatomical wall" EXACT []
synonym: "urinary bladder wall" EXACT []
synonym: "wall of bladder" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: UBERON:0001257
name: trigone of urinary bladder
def: "the smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa" []
synonym: "bladder trigone" EXACT []
synonym: "deep trigone" EXACT []
synonym: "dorsal bladder neck" RELATED []
synonym: "Lieutaud's trigone" EXACT []
synonym: "musculus trigoni vesicae profundus" EXACT []
synonym: "trigone of bladder" EXACT []
synonym: "trigonum vesicae" EXACT []
synonym: "trigonum vesicae urinariae" RELATED []
synonym: "urinary bladder trigone" EXACT []
synonym: "vesical trigone" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0006082 ! fundus of urinary bladder

[Term]
id: UBERON:0001258
name: neck of urinary bladder
def: "The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP]." []
synonym: "bladder neck" EXACT []
synonym: "cervix vesicae" EXACT []
synonym: "cervix vesicae urinariae" RELATED []
synonym: "collum vesicae" EXACT []
synonym: "neck of bladder" EXACT []
synonym: "urinary bladder neck" EXACT []
synonym: "vesical neck" EXACT []
is_a: UBERON:0001560 ! neck of organ
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: UBERON:0001259
name: mucosa of urinary bladder
def: "the mucous membrane lining the urinary bladder" []
synonym: "bladder mucosa" EXACT []
synonym: "bladder mucous membrane" EXACT []
synonym: "bladder organ mucosa" EXACT []
synonym: "mucosa of bladder" EXACT []
synonym: "mucous membrane of bladder" EXACT []
synonym: "mucous membrane of urinary bladder" EXACT []
synonym: "tunica mucosa (vesica urinaria)" EXACT []
synonym: "tunica mucosa vesicae" EXACT []
synonym: "tunica mucosa vesicae urinariae" EXACT []
synonym: "urinary bladder mucosa" EXACT []
synonym: "urinary bladder mucous membrane" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001256 ! wall of urinary bladder

[Term]
id: UBERON:0001260
name: serosa of urinary bladder
def: "A serous membrane that is part of a urinary bladder [Automatically generated definition]." []
synonym: "bladder serosa" EXACT []
synonym: "bladder serous membrane" EXACT []
synonym: "serosa of bladder" EXACT []
synonym: "serous coat of bladder" EXACT []
synonym: "serous coat of urinary bladder" EXACT []
synonym: "serous membrane of bladder" EXACT []
synonym: "serous membrane of urinary bladder" EXACT []
synonym: "tunica serosa (vesica urinaria)" EXACT []
synonym: "tunica serosa vesicae" EXACT []
synonym: "urinary bladder serosa" EXACT []
synonym: "urinary bladder serous membrane" EXACT []
synonym: "visceral peritoneum of urinary bladder" EXACT []
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001256 ! wall of urinary bladder

[Term]
id: UBERON:0001261
name: lamina propria of urinary bladder
def: "A lamina propria that is part of a urinary bladder [Automatically generated definition]." []
synonym: "bladder lamina propria" EXACT []
synonym: "bladder lamina propria mucosa" EXACT []
synonym: "bladder lamina propria mucosae" EXACT []
synonym: "lamina propria mucosa of bladder" EXACT []
synonym: "lamina propria mucosa of urinary bladder" EXACT []
synonym: "lamina propria mucosae of bladder" EXACT []
synonym: "lamina propria mucosae of urinary bladder" EXACT []
synonym: "lamina propria of bladder" EXACT []
synonym: "urinary bladder lamina propria" EXACT []
synonym: "urinary bladder lamina propria mucosa" EXACT []
synonym: "urinary bladder lamina propria mucosae" EXACT []
is_a: UBERON:0000030 ! lamina propria
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001256 ! wall of urinary bladder
relationship: part_of UBERON:0001259 ! mucosa of urinary bladder

[Term]
id: UBERON:0001262
name: wall of intestine
def: "An anatomical wall that is part of a intestine [Automatically generated definition]." []
synonym: "anatomical wall of bowel" EXACT []
synonym: "anatomical wall of intestine" EXACT []
synonym: "bowel anatomical wall" EXACT []
synonym: "bowel wall" EXACT []
synonym: "bowel wall" RELATED []
synonym: "intestinal wall" EXACT []
synonym: "intestine anatomical wall" EXACT []
synonym: "intestine wall" EXACT []
synonym: "wall of bowel" EXACT []
is_a: UBERON:0000328 ! gut wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine

[Term]
id: UBERON:0001263
name: pancreatic acinus
def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." []
synonym: "acinus pancreaticus" EXACT []
synonym: "pancreas acinus" EXACT []
synonym: "pancreatic acinar" RELATED []
synonym: "pancreatic acini" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0013232 ! serous acinus
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0007324 ! pancreatic lobule

[Term]
id: UBERON:0001264
name: pancreas
def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]." []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002075 ! viscus
relationship: has_part UBERON:0000016 ! endocrine pancreas

[Term]
id: UBERON:0001266
name: splenic cord
def: "A structure found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the human body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing. Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis." []
synonym: "cord of Billroth" EXACT []
synonym: "cord of Bilroth" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001250 ! red pulp of spleen

[Term]
id: UBERON:0001271
name: pelvic girdle region
def: "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." []
synonym: "girdle - pelvic" RELATED []
synonym: "pelvic girdle" RELATED []
is_a: UBERON:0007823 ! appendage girdle region
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0007823 ! appendage girdle region
intersection_of: part_of UBERON:0010709 ! pelvic complex
disjoint_from: UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0001276
name: epithelium of stomach
def: "The epithelial layer of the stomach ." []
synonym: "epithelial tissue of stomach" EXACT []
synonym: "epithelial tissue of ventriculus" EXACT []
synonym: "epithelium of ventriculus" EXACT []
synonym: "gastric epithelium" RELATED []
synonym: "stomach epithelial tissue" EXACT []
synonym: "stomach epithelium" EXACT []
synonym: "ventriculus epithelial tissue" EXACT []
synonym: "ventriculus epithelium" EXACT []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0004808 ! gastrointestinal system epithelium
is_a: UBERON:0015833 ! foregut epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0001199 ! mucosa of stomach

[Term]
id: UBERON:0001277
name: intestinal epithelium
def: "The innermost membrane of the four coats of the intestinal wall, the other three being the submucosa, muscular layers, and serosa. (Berk et al., Gastroenterology, 4th ed, v.3, p1479)" []
synonym: "bowel epithelial tissue" EXACT []
synonym: "bowel epithelium" EXACT []
synonym: "epithelial tissue of bowel" EXACT []
synonym: "epithelial tissue of intestine" EXACT []
synonym: "epithelium of bowel" EXACT []
synonym: "epithelium of intestine" EXACT []
synonym: "intestine epithelial tissue" EXACT []
synonym: "intestine epithelium" RELATED []
synonym: "villous epithelium" NARROW []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0003929 ! digestive tract epithelium
is_a: UBERON:0004808 ! gastrointestinal system epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: UBERON:0001278
name: epithelium of large intestine
def: "An epithelium that is part of a large intestine [Automatically generated definition]." []
synonym: "epithelial tissue of large intestine" EXACT []
synonym: "large intestinal epithelium" EXACT []
synonym: "large intestine epithelial tissue" EXACT []
synonym: "large intestine epithelium" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0001277 ! intestinal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001207 ! mucosa of large intestine

[Term]
id: UBERON:0001279
name: portal triad
def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" []
synonym: "trias hepatica" EXACT []
synonym: "trias hepatica" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0034921 ! multi organ part structure
relationship: has_part UBERON:0001193 ! hepatic artery
relationship: has_part UBERON:0002017 ! portal vein
relationship: has_part UBERON:0003704 ! intrahepatic bile duct
relationship: part_of UBERON:0001172 ! hepatic acinus

[Term]
id: UBERON:0001280
name: liver parenchyma
def: "The functional units of the liver including the lobules." []
synonym: "hepatic parenchyma" EXACT []
synonym: "hepatic parenchyme" RELATED []
synonym: "liver parenchyme" EXACT []
synonym: "parenchyma of liver" EXACT []
is_a: UBERON:0000353 ! parenchyma
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002107 ! liver
relationship: develops_from UBERON:0005171 ! hepatic duct
relationship: develops_from UBERON:0008835 ! hepatic diverticulum
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0001281
name: hepatic sinusoid
def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." []
synonym: "hepatic sinusoids" RELATED []
synonym: "liver hepatic sinusoids" EXACT []
synonym: "liver sinusoid" EXACT []
synonym: "liver sinusoidal blood vessel" EXACT []
synonym: "sinusoid of liver" EXACT []
synonym: "sinusoidal blood vessel of liver" EXACT []
synonym: "vas capillare sinusoideum" EXACT []
synonym: "vas sinusoideum" EXACT []
is_a: UBERON:0003909 ! sinusoid
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0015796 ! liver blood vessel
intersection_of: UBERON:0003909 ! sinusoid
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0004647 ! liver lobule
relationship: part_of UBERON:0006877 ! vasculature of liver

[Term]
id: UBERON:0001282
name: intralobular bile duct
def: "the tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule" []
synonym: "canal of Hering" RELATED []
synonym: "canal of Herring" EXACT []
synonym: "canals of Hering" RELATED []
synonym: "cholangiole" EXACT []
synonym: "duct of Herring" RELATED []
synonym: "ductus interlobularis bilifer" EXACT []
synonym: "intrahepatic bile ductule" RELATED []
is_a: UBERON:0003704 ! intrahepatic bile duct
is_a: UBERON:0014716 ! interlobular duct
relationship: part_of UBERON:0001172 ! hepatic acinus
relationship: part_of UBERON:0004647 ! liver lobule

[Term]
id: UBERON:0001285
name: nephron
def: "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]" []
synonym: "mature nephron" NARROW []
synonym: "nephroneum" RELATED []
synonym: "tubulus renalis" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme
relationship: part_of UBERON:0007684 ! uriniferous tubule

[Term]
id: UBERON:0001287
name: proximal convoluted tubule
def: "The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." []
synonym: "1st convoluted tubule" RELATED []
synonym: "first convoluted tubule" RELATED []
synonym: "kidney proximal convoluted tubule" RELATED []
synonym: "PCT" RELATED []
synonym: "proximal convoluted renal tubule" EXACT []
synonym: "renal proximal convoluted tubule" RELATED []
synonym: "tubulus contortus proximalis" EXACT []
synonym: "tubulus contortus proximalis" RELATED []
synonym: "tubulus convolutus proximalis" RELATED []
is_a: UBERON:0006534 ! renal convoluted tubule
is_a: UBERON:0006853 ! renal cortex tubule
is_a: UBERON:0008404 ! proximale tubular epithelium
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0004134 ! proximal tubule

[Term]
id: UBERON:0001288
name: loop of Henle
def: "the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" []
synonym: "ansa nephroni" EXACT []
synonym: "Henle loop" EXACT []
synonym: "henle's loop" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule

[Term]
id: UBERON:0001289
name: descending limb of loop of Henle
def: "the portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure" []
synonym: "descending limb" BROAD []
synonym: "descending limb of Henle's loop" EXACT []
synonym: "loop of Henle descending limb" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule
relationship: part_of UBERON:0001288 ! loop of Henle

[Term]
id: UBERON:0001290
name: proximal straight tubule
def: "The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." []
synonym: "pars recta" RELATED []
synonym: "pars recta tubuli renalis" RELATED []
synonym: "proximal tubule segment 3" RELATED []
synonym: "S3" EXACT []
synonym: "segment 3 of proximal tubule" RELATED []
synonym: "thick descending limb of proximal tubule" EXACT []
synonym: "tubulus rectus proximalis" EXACT []
is_a: UBERON:0006853 ! renal cortex tubule
is_a: UBERON:0008404 ! proximale tubular epithelium
is_a: UBERON:0009035 ! renal straight tubule
relationship: part_of UBERON:0001289 ! descending limb of loop of Henle
relationship: part_of UBERON:0004134 ! proximal tubule
relationship: part_of UBERON:0006542 ! outer medulla outer stripe loop of henle

[Term]
id: UBERON:0001291
name: thick ascending limb of loop of Henle
def: "the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" []
synonym: "ascending thick limb" EXACT []
synonym: "distal straight tubule" EXACT []
synonym: "loop of Henle ascending limb thick segment" EXACT []
synonym: "straight portion of distal convoluted renal tubule" EXACT []
synonym: "straight portion of distal convoluted tubule" EXACT []
synonym: "thick ascending limb" EXACT []
synonym: "thick ascending limb of distal tubule" EXACT []
synonym: "thick ascending limb of Henle's loop" EXACT []
synonym: "tubulus rectus distalis" EXACT []
synonym: "tubulus rectus distalis" RELATED []
is_a: UBERON:0008408 ! distal tubular epithelium
is_a: UBERON:0009035 ! renal straight tubule
relationship: part_of UBERON:0004135 ! distal tubule
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle

[Term]
id: UBERON:0001292
name: distal convoluted tubule
def: "The first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa." []
synonym: "distal convoluted renal tubule" EXACT []
synonym: "second convoluted tubule" RELATED []
synonym: "tubulus contortus distalis" EXACT []
synonym: "tubulus contortus distalis" RELATED []
synonym: "tubulus convolutus distalis" RELATED []
is_a: UBERON:0006534 ! renal convoluted tubule
is_a: UBERON:0006853 ! renal cortex tubule
is_a: UBERON:0008408 ! distal tubular epithelium
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0004135 ! distal tubule

[Term]
id: UBERON:0001293
name: outer medulla of kidney
def: "The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla[GO]." []
synonym: "kidney outer medulla" RELATED []
synonym: "outer renal medulla" EXACT []
synonym: "outer zone of medulla of kidney" EXACT []
synonym: "outer zone of renal medulla" EXACT []
synonym: "renal outer medulla" EXACT []
synonym: "set of outer region of renal pyramids" RELATED []
synonym: "zona externa (medullaris renalis)" EXACT []
synonym: "zona externa medullae renalis" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0001294
name: inner medulla of kidney
def: "Innermost region of the mammalian kidney." []
synonym: "inner renal medulla" EXACT []
synonym: "inner zone of medulla of kidney" EXACT []
synonym: "inner zone of renal medulla" EXACT []
synonym: "kidney inner medulla" RELATED []
synonym: "renal inner medulla" EXACT []
synonym: "set of inner region of renal pyramids" EXACT []
synonym: "zona interna (medullaris renalis)" EXACT []
synonym: "zona interna medullae renalis" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0001295
name: endometrium
def: "the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" []
synonym: "tunica mucosa (endometrium)" EXACT []
synonym: "tunica mucosa uteri" EXACT []
synonym: "uterine endometrium" EXACT []
synonym: "uterine mucosa" RELATED []
synonym: "uterine mucous membrane" RELATED []
is_a: UBERON:0019042 ! reproductive system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000459 ! uterine wall
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0001296
name: myometrium
def: "the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" []
synonym: "tunica muscularis" RELATED []
synonym: "tunica muscularis (myometrium)" EXACT []
synonym: "uterine myometrium" RELATED []
synonym: "uterine smooth muscle" RELATED []
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0034933 ! layer of smooth muscle tissue
relationship: part_of UBERON:0000459 ! uterine wall

[Term]
id: UBERON:0001297
name: serosa of uterus
def: "Outer serosa layer of the uterus." []
synonym: "perimetrium" EXACT []
synonym: "serous coat of uterus" EXACT []
synonym: "serous membrane of uterus" EXACT []
synonym: "tunica serosa (perimetrium)" EXACT []
synonym: "tunica serosa uteri" EXACT []
synonym: "uterine serosa" EXACT []
synonym: "uterus serosa" EXACT []
synonym: "uterus serous membrane" EXACT []
synonym: "visceral peritoneum of uterus" EXACT []
is_a: UBERON:0000042 ! serous membrane
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000459 ! uterine wall
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0001301
name: epididymis
def: "the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" []
synonym: "epididymus" EXACT []
synonym: "Nebenhoden@ge" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005904 ! duct of male reproductive system
relationship: develops_from UBERON:0003074 ! mesonephric duct
relationship: part_of UBERON:0006947 ! male genital duct

[Term]
id: UBERON:0001305
name: ovarian follicle
def: "A spherical aggregation of cells in the ovary that contains a single oocyte[WP,modified]." []
synonym: "egg follicle" RELATED []
synonym: "follicle of ovary" EXACT []
synonym: "follicle of ovary viewed macroscopically" EXACT []
synonym: "folliculi ovarici primarii" RELATED []
synonym: "folliculi ovarici vesiculosi" RELATED []
synonym: "ovary follicle" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
relationship: develops_from UBERON:0005296 ! ovary sex cord
relationship: has_part UBERON:0000038 ! follicular fluid
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0001310
name: umbilical artery
def: "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." []
synonym: "a. umbilicalis" RELATED []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0010260 ! umbilical blood vessel

[Term]
id: UBERON:0001319
name: vaginal vein
def: "One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified]." []
synonym: "vagina vein" EXACT []
synonym: "vein of vagina" EXACT []
is_a: UBERON:0001638 ! vein
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0001325
name: muscle of pelvis
def: "Muscle (organ) which is a part of the pelvis. Examples: levator ani," []
synonym: "muscle organ of pelvis" EXACT []
synonym: "pelvic muscle" EXACT []
synonym: "pelvis muscle" EXACT []
synonym: "pelvis muscle organ" EXACT []
is_a: UBERON:0003833 ! abdominal segment muscle
is_a: UBERON:0005179 ! pelvic region element
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0001328
name: lobe of prostate
def: "A portion of a prostate that forms a lobe." []
synonym: "lobe of prostate gland" EXACT []
synonym: "prostate gland lobe" EXACT []
synonym: "prostatic lobe" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0009912 ! anatomical lobe
intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0001331
name: skin of penis
def: "A zone of skin that is part of a penis [Automatically generated definition]." []
synonym: "penile skin" EXACT []
synonym: "penis skin" EXACT []
synonym: "penis zone of skin" EXACT []
synonym: "zone of skin of penis" EXACT []
is_a: UBERON:0000014 ! zone of skin
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000989 ! penis
relationship: part_of UBERON:0000989 ! penis

[Term]
id: UBERON:0001332
name: prepuce of penis
def: "A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect." []
synonym: "foreskin" RELATED []
synonym: "penile prepuce" EXACT []
synonym: "praeputium" RELATED []
synonym: "prepuce" BROAD []
synonym: "prepuce of male" EXACT []
synonym: "prepucium" RELATED []
synonym: "preputium" BROAD []
synonym: "preputium penis" EXACT []
is_a: UBERON:0011374 ! prepuce
intersection_of: UBERON:0011374 ! prepuce
intersection_of: part_of UBERON:0000989 ! penis
relationship: part_of UBERON:0000989 ! penis

[Term]
id: UBERON:0001333
name: male urethra
def: "A urethra that is part of a male reproductive system." []
is_a: UBERON:0000057 ! urethra
intersection_of: UBERON:0000057 ! urethra
intersection_of: part_of UBERON:0003101 ! male organism
relationship: part_of UBERON:0003101 ! male organism

[Term]
id: UBERON:0001334
name: female urethra
def: "A urethra that is part of a female reproductive system." []
synonym: "urethra feminina" RELATED []
synonym: "urethra muliebris" RELATED []
is_a: UBERON:0000057 ! urethra
intersection_of: UBERON:0000057 ! urethra
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0003100 ! female organism

[Term]
id: UBERON:0001338
name: urethral gland
def: "Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine" []
synonym: "gland of urethra" EXACT []
synonym: "urethra gland" EXACT []
synonym: "urethra gland (male or female)" EXACT []
synonym: "urethral mucuous gland" EXACT []
is_a: UBERON:0000414 ! mucous gland
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0001343
name: seminiferous tubule of testis
def: "the tubules in the testes where spermatogenesis occurs" []
synonym: "seminiferous cord" EXACT []
synonym: "seminiferous tubule" EXACT []
synonym: "testis - seminiferous tubule" EXACT []
synonym: "tubuli seminiferi" EXACT []
synonym: "tubuli seminiferi" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005904 ! duct of male reproductive system
relationship: develops_from UBERON:0005297 ! testis sex cord
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0001344
name: epithelium of vagina
def: "The epithelial layer of the vagina." []
synonym: "epithelial tissue of vagina" EXACT []
synonym: "epithelium, vaginal" RELATED []
synonym: "vagina epithelial tissue" EXACT []
synonym: "vagina epithelium" EXACT []
synonym: "vaginal epithelium" EXACT []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0004804 ! oviduct epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0001347
name: white adipose tissue
def: "Connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels[MP,modified]" []
synonym: "adipocytus unigutturalis" EXACT []
synonym: "textus adiposus albus" EXACT []
synonym: "textus adiposus albus" RELATED []
synonym: "unilocular adipose tissue" EXACT []
synonym: "white fat" EXACT []
is_a: UBERON:0001013 ! adipose tissue

[Term]
id: UBERON:0001348
name: brown adipose tissue
def: "A thermogenic form of adipose tissue that is composed of brown adipocytes[MP,modified]" []
synonym: "adipocytus multigutturalis" EXACT []
synonym: "brown fat" EXACT []
synonym: "multilocular adipose tissue" EXACT []
synonym: "textus adiposus fuscus" EXACT []
synonym: "textus adiposus fuscus" RELATED []
is_a: UBERON:0001013 ! adipose tissue

[Term]
id: UBERON:0001351
name: lacrimal sac
def: "The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue." []
synonym: "lachrymal sac" EXACT []
synonym: "lacrymal sac" EXACT []
synonym: "saccus lacrimalis" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0002392 ! nasolacrimal duct

[Term]
id: UBERON:0001352
name: external acoustic meatus
def: "A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter." []
synonym: "auditory canal" EXACT []
synonym: "auditory meatus" RELATED []
synonym: "ear canal" EXACT []
synonym: "external acoustic tube" EXACT []
synonym: "external auditory canal" EXACT []
synonym: "external auditory meatus" RELATED []
synonym: "external auditory tube" EXACT []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0005872 ! 1st arch pharyngeal cleft
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0001353
name: anal region
def: "The anus and surrounding regions. Encompasses both internal and external regions, where present" []
synonym: "posterior" RELATED []
synonym: "posterior end of organism" RELATED []
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0001366
name: parietal peritoneum
def: "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." []
synonym: "parietal serous membrane of peritoneum" EXACT []
synonym: "peritoneal cavity lining" RELATED []
is_a: UBERON:0022351 ! parietal serous membrane
intersection_of: UBERON:0022351 ! parietal serous membrane
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum

[Term]
id: UBERON:0001383
name: muscle of leg
def: "A muscle that is part of the region of the hindlimb between the pelvis and ankle." []
synonym: "leg muscle" EXACT []
synonym: "leg muscle organ" EXACT []
synonym: "leg skeletal muscle" EXACT []
synonym: "leg skeletal muscle tissue" EXACT []
synonym: "muscle of hindlimb zeugopod or stylopod" EXACT []
synonym: "muscle of thigh or crus" EXACT []
synonym: "muscle of upper or lower hindlimb segment" EXACT []
synonym: "muscle of upper/lower leg" EXACT []
synonym: "muscle organ of leg" EXACT []
synonym: "skeletal muscle of leg" EXACT []
is_a: UBERON:0003663 ! hindlimb muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0004466 ! musculature of leg

[Term]
id: UBERON:0001384
name: primary motor cortex
def: "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html" []
synonym: "excitable area" RELATED []
synonym: "gyrus precentralis" RELATED []
synonym: "motor area" RELATED []
synonym: "motor cortex" EXACT []
synonym: "prefrontal gyrus" RELATED []
synonym: "primary motor area" RELATED []
synonym: "Rolando's area" RELATED []
synonym: "somatic motor areas" RELATED []
synonym: "somatomotor areas" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0001870 ! frontal cortex
relationship: part_of UBERON:0001950 ! neocortex

[Term]
id: UBERON:0001415
name: skin of pelvis
def: "A zone of skin that is part of a pelvis [Automatically generated definition]." []
synonym: "pelvic skin" EXACT []
synonym: "pelvis skin" EXACT []
synonym: "pelvis zone of skin" EXACT []
synonym: "zone of skin of pelvis" EXACT []
is_a: UBERON:0003836 ! abdominal segment skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0001416
name: skin of abdomen
def: "A zone of skin that is part of an abdomen [Automatically generated definition]." []
synonym: "abdomen skin" EXACT []
synonym: "abdomen zone of skin" EXACT []
synonym: "abdominal skin" EXACT []
synonym: "skin of abdomen proper" EXACT []
synonym: "zone of skin of abdomen" EXACT []
is_a: UBERON:0003836 ! abdominal segment skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0001418
name: skin of thorax
def: "A zone of skin that is part of a thorax [Automatically generated definition]." []
synonym: "thoracic skin" EXACT []
synonym: "thorax skin" EXACT []
synonym: "thorax zone of skin" EXACT []
synonym: "upper body skin" RELATED []
synonym: "zone of skin of thorax" EXACT []
is_a: UBERON:0001085 ! skin of trunk
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0001419
name: skin of limb
def: "A zone of skin that is part of a limb [Automatically generated definition]." []
synonym: "limb skin" EXACT []
synonym: "limb zone of skin" EXACT []
synonym: "zone of skin of limb" EXACT []
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0001421
name: pectoral girdle region
def: "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." []
synonym: "cingulum membri superioris" EXACT []
synonym: "cingulum membri superioris" NARROW []
synonym: "girdle - pectoral" EXACT []
synonym: "pectoral girdle" RELATED []
synonym: "pectoral region" RELATED []
synonym: "shoulder girdle" NARROW []
synonym: "upper limb girdle" NARROW []
is_a: UBERON:0007823 ! appendage girdle region
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0007823 ! appendage girdle region
intersection_of: part_of UBERON:0010708 ! pectoral complex
disjoint_from: UBERON:0007831 ! pectoral girdle skeleton
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0001422
name: facial lymphatic vessel
def: "A lymphatic vessel that is part of a face [Automatically generated definition]." []
synonym: "buccal lymphatic vessel" EXACT []
synonym: "face lymph vessel" EXACT []
synonym: "face lymphatic vessel" EXACT []
synonym: "FL" RELATED []
synonym: "lymph vessel of face" EXACT []
synonym: "lymphatic vessel of face" EXACT []
is_a: UBERON:0001473 ! lymphatic vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0001434
name: skeletal system
def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." []
synonym: "set of all bones and joints" NARROW []
synonym: "skeleton system" EXACT []
synonym: "Skelettsystem" RELATED []
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: has_part UBERON:0004288 ! skeleton
intersection_of: has_part UBERON:0004770 ! articular system
disjoint_from: UBERON:0001474 ! bone element
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0004288 ! skeleton
relationship: has_part UBERON:0004770 ! articular system
relationship: part_of UBERON:0002204 ! musculoskeletal system

[Term]
id: UBERON:0001436
name: phalanx of manus
def: "A phalanx that is part of a forelimb autopod[Automatically generated definition]." []
synonym: "bone of finger" RELATED []
synonym: "digital bone of manus" NARROW []
synonym: "digitus manus phalanx" EXACT []
synonym: "finger phalanx" EXACT []
synonym: "hand digit phalanx" EXACT []
synonym: "hand phalanx" EXACT []
synonym: "manual phalanx" EXACT []
synonym: "phalanges of fore digit" RELATED []
synonym: "phalanx of digit of hand" EXACT []
synonym: "phalanx of digitus manus" EXACT []
synonym: "phalanx of finger" EXACT []
synonym: "phalanx of fore digit" EXACT []
synonym: "phalanx of hand" EXACT []
synonym: "phalanx of hand digit" EXACT []
synonym: "phalanx of manual digit" EXACT []
is_a: UBERON:0003221 ! phalanx
is_a: UBERON:0003607 ! forelimb long bone
is_a: UBERON:0004249 ! manual digit bone
is_a: UBERON:0015024 ! manual digit phalanx endochondral element
intersection_of: UBERON:0003221 ! phalanx
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: develops_from UBERON:0010686 ! manual digit phalanx cartilage element
relationship: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0010688 ! skeleton of manual acropodium
relationship: part_of UBERON:5102389 ! manual digit digitopodial skeleton

[Term]
id: UBERON:0001438
name: metaphysis
def: "Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]" []
synonym: "diaphyseal end of long bone" EXACT []
synonym: "long bone metaphysis" EXACT []
synonym: "metaphyses" EXACT []
is_a: UBERON:0005055 ! zone of long bone
relationship: part_of UBERON:0004769 ! diaphysis

[Term]
id: UBERON:0001440
name: forelimb skeleton
def: "The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle" []
synonym: "bones of upper limb" EXACT []
synonym: "fore limb skeleton" EXACT []
synonym: "forelimb skeleton" EXACT []
synonym: "free upper limb skeleton" EXACT []
synonym: "ossa membri superioris" EXACT []
synonym: "pectoral limb skeleton" EXACT []
synonym: "set of bones of upper limb" EXACT []
synonym: "skeleton of forelimb" EXACT []
synonym: "skeleton of free upper limb" EXACT []
synonym: "skeleton of pectoral limb" EXACT []
synonym: "skeleton of upper limb" EXACT []
synonym: "upper limb skeleton" EXACT []
synonym: "wing skeleton" NARROW []
is_a: UBERON:0004381 ! skeleton of limb
is_a: UBERON:0007272 ! pectoral appendage skeleton
relationship: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0012475 ! skeleton of pectoral complex

[Term]
id: UBERON:0001441
name: hindlimb skeleton
def: "Subdivision of skeleton consisting of all skeletal elements in an hindlimb region." []
synonym: "bones of lower limb" EXACT []
synonym: "free lower limb skeleton" EXACT []
synonym: "hind limb skeleton" EXACT []
synonym: "hind-limb skeleton" EXACT []
synonym: "hindlimb skeleton" EXACT []
synonym: "lower limb skeleton" EXACT []
synonym: "ossa membri inferioris" EXACT []
synonym: "set of bones of lower limb" EXACT []
synonym: "skeleton of free lower limb" EXACT []
synonym: "skeleton of lower limb" EXACT []
is_a: UBERON:0004381 ! skeleton of limb
is_a: UBERON:0007273 ! pelvic appendage skeleton
relationship: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0012476 ! skeleton of pelvic complex

[Term]
id: UBERON:0001442
name: skeleton of manus
def: "Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape]." []
synonym: "anterior autopodium" RELATED []
synonym: "anterior autopodium skeleton" EXACT []
synonym: "bones of hand" EXACT []
synonym: "fore autopod skeleton" EXACT []
synonym: "forelimb autopod skeleton" EXACT []
synonym: "hand region skeleton" EXACT []
synonym: "hand skeleton" EXACT []
synonym: "manual skeleton" EXACT []
synonym: "manus" RELATED []
synonym: "manus skeleton" EXACT []
synonym: "ossa manus" EXACT []
synonym: "set of bones of hand" EXACT []
synonym: "skeleton of hand" EXACT []
is_a: UBERON:0006717 ! autopodial skeleton
disjoint_from: UBERON:0001445 ! skeleton of pes
relationship: part_of UBERON:0001440 ! forelimb skeleton
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0001443
name: chest
def: "Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]." []
synonym: "anterolateral part of thorax" EXACT []
synonym: "front of thorax" EXACT []
synonym: "pectus" EXACT []
synonym: "thoracic body wall" RELATED []
synonym: "thorax" RELATED []
synonym: "ventral part of thoracic region" EXACT []
is_a: UBERON:0009569 ! subdivision of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0001444
name: subdivision of head
synonym: "head region" RELATED []
synonym: "head subdivision" EXACT []
synonym: "region of head" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0001445
name: skeleton of pes
def: "Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape]." []
synonym: "foot region skeleton" EXACT []
synonym: "foot skeleton" EXACT []
synonym: "pedal skeleton" EXACT []
synonym: "pes" RELATED []
synonym: "pes skeleton" EXACT []
synonym: "posterior autopodium" RELATED []
synonym: "posterior autopodium skeleton" EXACT []
synonym: "set of bones of foot" EXACT []
synonym: "skeleton of foot" EXACT []
is_a: UBERON:0006717 ! autopodial skeleton
relationship: part_of UBERON:0001441 ! hindlimb skeleton
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0001449
name: phalanx of pes
def: "A phalanx that is part of a hindlimb autopod[Automatically generated definition]." []
synonym: "bone of toe" RELATED []
synonym: "digital bone of pes" BROAD []
synonym: "digitus pedis phalanx" EXACT []
synonym: "foot digit phalanx" EXACT []
synonym: "foot phalanx" EXACT []
synonym: "pedal phalanx" EXACT []
synonym: "phalanges of hind digit" RELATED []
synonym: "phalanx of digit of foot" EXACT []
synonym: "phalanx of digitus pedis" EXACT []
synonym: "phalanx of foot digit" EXACT []
synonym: "phalanx of hind digit" EXACT []
synonym: "phalanx of pes" EXACT []
synonym: "phalanx of toe" EXACT []
synonym: "toe phalanx" EXACT []
is_a: UBERON:0003221 ! phalanx
is_a: UBERON:0003608 ! hindlimb long bone
is_a: UBERON:0004248 ! pedal digit bone
is_a: UBERON:0015030 ! pedal digit phalanx endochondral element
intersection_of: UBERON:0003221 ! phalanx
intersection_of: part_of UBERON:0002387 ! pes
relationship: develops_from UBERON:0010685 ! pedal digit phalanx cartilage element
relationship: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0010696 ! skeleton of pedal acropodium
relationship: part_of UBERON:5101466 ! pedal digit digitopodial skeleton

[Term]
id: UBERON:0001456
name: face
def: "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." []
synonym: "facia/facies" RELATED []
synonym: "visage" RELATED []
is_a: UBERON:0001444 ! subdivision of head
relationship: has_part UBERON:0000165 ! mouth

[Term]
id: UBERON:0001457
name: skin of eyelid
def: "A zone of skin that is part of a eyelid [Automatically generated definition]." []
synonym: "blepharon zone of skin" EXACT []
synonym: "eyelid skin" EXACT []
synonym: "eyelid zone of skin" EXACT []
synonym: "zone of skin of blepharon" EXACT []
synonym: "zone of skin of eyelid" EXACT []
is_a: UBERON:1000021 ! skin of face
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0001459
name: skin of external ear
def: "A zone of skin that is part of a external ear [Automatically generated definition]." []
synonym: "auricular region of head zone of skin" EXACT []
synonym: "auricular region zone of skin" EXACT []
synonym: "ear skin" EXACT []
synonym: "external ear skin" EXACT []
synonym: "external ear zone of skin" EXACT []
synonym: "outer ear zone of skin" EXACT []
synonym: "zone of skin of auricular region" EXACT []
synonym: "zone of skin of auricular region of head" EXACT []
synonym: "zone of skin of external ear" EXACT []
synonym: "zone of skin of outer ear" EXACT []
is_a: UBERON:0001084 ! skin of head
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001691 ! external ear
relationship: part_of UBERON:0001691 ! external ear
relationship: part_of UBERON:0001757 ! pinna

[Term]
id: UBERON:0001460
name: arm
def: "The part of the forelimb extending from the shoulder to the autopod[cjm]." []
synonym: "brachium" RELATED []
synonym: "upper extremity" RELATED []
is_a: UBERON:0006058 ! multi-limb segment region
is_a: UBERON:0008785 ! upper limb segment
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0001464
name: hip
def: "The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified]." []
synonym: "coxa" RELATED []
synonym: "hip region" EXACT []
synonym: "regio coxae" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0001465
name: knee
def: "A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod." []
synonym: "knee region" EXACT []
is_a: UBERON:0008784 ! lower limb segment
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0001466
name: pedal digit
def: "A digit that is part of a pes (foot)." []
synonym: "digit of foot" EXACT []
synonym: "digit of terminal segment of lower limb" EXACT []
synonym: "digiti pedis" EXACT []
synonym: "digiti pedis" RELATED []
synonym: "digitipedis" RELATED []
synonym: "digitus pedis" EXACT []
synonym: "foot digit" EXACT []
synonym: "hind digit" EXACT []
synonym: "hind_digit" EXACT []
synonym: "hindlimb digit" EXACT []
synonym: "pedal digit (phalangeal portion) plus soft tissue" EXACT []
synonym: "pes digit" EXACT []
synonym: "toe" EXACT []
is_a: UBERON:0002544 ! digit
intersection_of: UBERON:0002544 ! digit
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012142 ! pedal digitopodium region
relationship: part_of UBERON:5001466 ! pedal digit plus metapodial segment

[Term]
id: UBERON:0001467
name: shoulder
def: "A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle)." []
synonym: "articulatio humeri" RELATED []
synonym: "shoulder region" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0016884 ! shoulder joint
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0001468
name: intervertebral joint
def: "The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments." []
synonym: "inter-centrum joint" EXACT []
synonym: "inter-vertebral joint" EXACT []
synonym: "intervertebral symphysis" EXACT []
synonym: "joint of vertebral body" EXACT []
synonym: "vertebral joint" BROAD []
is_a: UBERON:0002216 ! symphysis
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001130 ! vertebral column

[Term]
id: UBERON:0001471
name: skin of prepuce of penis
def: "the loose fold of skin that covers the penis" []
synonym: "foreskin of penis" EXACT []
synonym: "penis foreskin" EXACT []
synonym: "preputial skin" EXACT []
is_a: UBERON:0001331 ! skin of penis
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis

[Term]
id: UBERON:0001473
name: lymphatic vessel
def: "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." []
synonym: "lymph vessel" EXACT []
synonym: "vas lymphaticum" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000055 ! vessel
intersection_of: UBERON:0000055 ! vessel
intersection_of: part_of UBERON:0004536 ! lymph vasculature
disjoint_from: UBERON:0001981 ! blood vessel
relationship: has_part UBERON:0002391 ! lymph
relationship: part_of UBERON:0004536 ! lymph vasculature
relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system

[Term]
id: UBERON:0001474
name: bone element
def: "Skeletal element that is composed of bone tissue." []
synonym: "bone" RELATED []
synonym: "bone element" EXACT []
synonym: "bone organ" EXACT []
synonym: "bones" RELATED []
is_a: UBERON:0004765 ! skeletal element
disjoint_from: UBERON:0001630 ! muscle organ
disjoint_from: UBERON:0005090 ! muscle structure
disjoint_from: UBERON:0010538 ! paired limb/fin segment
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0001482
name: muscle of shoulder
def: "Any muscle organ that is part of a shoulder [Automatically generated definition]." []
synonym: "muscle organ of shoulder" EXACT []
synonym: "shoulder muscle" EXACT []
synonym: "shoulder muscle organ" EXACT []
is_a: UBERON:0014892 ! skeletal muscle organ
relationship: part_of UBERON:0004476 ! musculature of shoulder

[Term]
id: UBERON:0001483
name: skin of shoulder
def: "A zone of skin that is part of a shoulder region." []
synonym: "shoulder skin" EXACT []
synonym: "shoulder zone of skin" EXACT []
synonym: "zone of skin of shoulder" EXACT []
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0001485
name: knee joint
def: "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." []
synonym: "articulatio genus" RELATED []
synonym: "joint of knee" EXACT []
is_a: UBERON:0003840 ! hindlimb joint
is_a: UBERON:0011139 ! synovial limb joint
relationship: develops_from UBERON:0006256 ! knee joint primordium
relationship: part_of UBERON:0001465 ! knee

[Term]
id: UBERON:0001487
name: pes joint
def: "A skeletal joint that is part of a pes [Automatically generated definition]." []
synonym: "articulationes pedis" EXACT []
synonym: "foot joint" EXACT []
synonym: "hind limb autopod joint" EXACT []
synonym: "joint of pes" EXACT []
synonym: "joint of terminal segment of free lower limb" EXACT []
synonym: "joints of foot" EXACT []
synonym: "pedal joint" EXACT []
is_a: UBERON:0003840 ! hindlimb joint
is_a: UBERON:0003841 ! autopod joint
is_a: UBERON:0011139 ! synovial limb joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0001489
name: manus joint
def: "A skeletal joint that is part of a manus (hand) [Automatically generated definition]." []
synonym: "articulationes manus" EXACT []
synonym: "hand joint" EXACT []
synonym: "joint of hand" EXACT []
synonym: "joint of manus" EXACT []
synonym: "joint of terminal segment of free upper limb" EXACT []
synonym: "manual joint" EXACT []
is_a: UBERON:0003839 ! forelimb joint
is_a: UBERON:0003841 ! autopod joint
is_a: UBERON:0011139 ! synovial limb joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0001495
name: pectoral muscle
def: "Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs." []
synonym: "breast muscle" RELATED []
synonym: "M. pectoralis" EXACT []
synonym: "muscle of pectoral part of chest" EXACT []
synonym: "muscle of pectoral region" EXACT []
synonym: "pectoralis" RELATED []
synonym: "pectoralis group muscle" RELATED []
synonym: "pectoralis muscle" RELATED []
is_a: UBERON:0003830 ! thoracic segment muscle
is_a: UBERON:0008196 ! muscle of pectoral girdle
relationship: develops_from UBERON:0010984 ! pectoral pre-muscle mass
relationship: part_of UBERON:0004464 ! musculature of thorax

[Term]
id: UBERON:0001497
name: muscle of pelvic girdle
def: "Any muscle organ that is part of a pelvic girdle [Automatically generated definition]." []
synonym: "girdle-pelvic muscle organ" EXACT []
synonym: "muscle organ of girdle-pelvic" EXACT []
synonym: "muscle organ of pelvic girdle" EXACT []
synonym: "muscle organ of pelvic girdle bone" EXACT []
synonym: "pelvic girdle muscle" EXACT []
synonym: "pelvic girdle muscle organ" EXACT []
synonym: "pelvic girdle skeletal muscle" EXACT []
is_a: UBERON:0001325 ! muscle of pelvis
is_a: UBERON:0010890 ! pelvic complex muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0004470 ! musculature of pelvic girdle

[Term]
id: UBERON:0001498
name: muscle of pes
def: "Any muscle organ that is part of a pes [Automatically generated definition]." []
synonym: "autopod of hind limb muscle organ" EXACT []
synonym: "autopod of hindlimb muscle organ" EXACT []
synonym: "autopod of inferior member muscle organ" EXACT []
synonym: "autopod of lower extremity muscle organ" EXACT []
synonym: "distal free limb segment of hind limb muscle organ" EXACT []
synonym: "distal free limb segment of hindlimb muscle organ" EXACT []
synonym: "distal free limb segment of inferior member muscle organ" EXACT []
synonym: "distal free limb segment of lower extremity muscle organ" EXACT []
synonym: "foot muscle" EXACT []
synonym: "foot muscle organ" EXACT []
synonym: "hind limb autopod muscle organ" EXACT []
synonym: "hind limb distal free limb segment muscle organ" EXACT []
synonym: "hindlimb autopod muscle organ" EXACT []
synonym: "hindlimb distal free limb segment muscle organ" EXACT []
synonym: "inferior member autopod muscle organ" EXACT []
synonym: "inferior member distal free limb segment muscle organ" EXACT []
synonym: "lower extremity autopod muscle organ" EXACT []
synonym: "lower extremity distal free limb segment muscle organ" EXACT []
synonym: "muscle of foot" EXACT []
synonym: "muscle organ of autopod of hind limb" EXACT []
synonym: "muscle organ of autopod of hindlimb" EXACT []
synonym: "muscle organ of autopod of inferior member" EXACT []
synonym: "muscle organ of autopod of lower extremity" EXACT []
synonym: "muscle organ of distal free limb segment of hind limb" EXACT []
synonym: "muscle organ of distal free limb segment of hindlimb" EXACT []
synonym: "muscle organ of distal free limb segment of inferior member" EXACT []
synonym: "muscle organ of distal free limb segment of lower extremity" EXACT []
synonym: "muscle organ of foot" EXACT []
synonym: "muscle organ of hind limb autopod" EXACT []
synonym: "muscle organ of hind limb distal free limb segment" EXACT []
synonym: "muscle organ of hindlimb autopod" EXACT []
synonym: "muscle organ of hindlimb distal free limb segment" EXACT []
synonym: "muscle organ of inferior member autopod" EXACT []
synonym: "muscle organ of inferior member distal free limb segment" EXACT []
synonym: "muscle organ of lower extremity autopod" EXACT []
synonym: "muscle organ of lower extremity distal free limb segment" EXACT []
synonym: "muscle organ of terminal segment of free lower limb" EXACT []
synonym: "terminal segment of free lower limb muscle organ" EXACT []
is_a: UBERON:0003663 ! hindlimb muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0004488 ! musculature of pes

[Term]
id: UBERON:0001499
name: muscle of arm
def: "A muscle organ that is part of an arm [Automatically generated definition]." []
synonym: "arm muscle" EXACT []
synonym: "arm muscle system" RELATED []
synonym: "arm skeletal muscle" EXACT []
synonym: "arm skeletal muscle tissue" EXACT []
synonym: "muscle of upper arm or lower arm" EXACT []
synonym: "upper arm / lower arm muscle" EXACT []
is_a: UBERON:0003662 ! forelimb muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0004474 ! musculature of arm

[Term]
id: UBERON:0001500
name: muscle of manus
def: "Any muscle organ that is part of a manus [Automatically generated definition]." []
synonym: "arm autopod muscle organ" EXACT []
synonym: "arm distal free limb segment muscle organ" EXACT []
synonym: "autopod of arm muscle organ" EXACT []
synonym: "autopod of brachial region muscle organ" EXACT []
synonym: "autopod of proximal segment of free upper limb muscle organ" EXACT []
synonym: "brachial region autopod muscle organ" EXACT []
synonym: "brachial region distal free limb segment muscle organ" EXACT []
synonym: "distal free limb segment of arm muscle organ" EXACT []
synonym: "distal free limb segment of brachial region muscle organ" EXACT []
synonym: "distal free limb segment of proximal segment of free upper limb muscle organ" EXACT []
synonym: "hand muscle" EXACT []
synonym: "manus muscle" EXACT []
synonym: "manus muscle organ" EXACT []
synonym: "muscle of hand" EXACT []
synonym: "muscle organ of arm autopod" EXACT []
synonym: "muscle organ of arm distal free limb segment" EXACT []
synonym: "muscle organ of autopod of arm" EXACT []
synonym: "muscle organ of autopod of brachial region" EXACT []
synonym: "muscle organ of autopod of proximal segment of free upper limb" EXACT []
synonym: "muscle organ of brachial region autopod" EXACT []
synonym: "muscle organ of brachial region distal free limb segment" EXACT []
synonym: "muscle organ of distal free limb segment of arm" EXACT []
synonym: "muscle organ of distal free limb segment of brachial region" EXACT []
synonym: "muscle organ of distal free limb segment of proximal segment of free upper limb" EXACT []
synonym: "muscle organ of manus" EXACT []
synonym: "muscle organ of proximal segment of free upper limb autopod" EXACT []
synonym: "muscle organ of proximal segment of free upper limb distal free limb segment" EXACT []
synonym: "muscle organ of terminal segment of free upper limb" EXACT []
synonym: "proximal segment of free upper limb autopod muscle organ" EXACT []
synonym: "proximal segment of free upper limb distal free limb segment muscle organ" EXACT []
synonym: "terminal segment of free upper limb muscle organ" EXACT []
is_a: UBERON:0003662 ! forelimb muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0004489 ! musculature of manus

[Term]
id: UBERON:0001510
name: skin of knee
def: "A zone of skin that is part of a knee [Automatically generated definition]." []
synonym: "knee skin" EXACT []
synonym: "knee zone of skin" EXACT []
synonym: "zone of skin of knee" EXACT []
is_a: UBERON:0001511 ! skin of leg
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001465 ! knee
relationship: part_of UBERON:0001465 ! knee

[Term]
id: UBERON:0001511
name: skin of leg
def: "A zone of skin that is part of a leg [Automatically generated definition]." []
synonym: "leg skin" EXACT []
synonym: "leg zone of skin" EXACT []
synonym: "zone of skin of leg" EXACT []
is_a: UBERON:0003532 ! hindlimb skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0001513
name: skin of pes
def: "A zone of skin that is part of a pes [Automatically generated definition]." []
synonym: "autopod of hind limb zone of skin" EXACT []
synonym: "autopod of hindlimb zone of skin" EXACT []
synonym: "autopod of inferior member zone of skin" EXACT []
synonym: "autopod of lower extremity zone of skin" EXACT []
synonym: "distal free limb segment of hind limb zone of skin" EXACT []
synonym: "distal free limb segment of hindlimb zone of skin" EXACT []
synonym: "distal free limb segment of inferior member zone of skin" EXACT []
synonym: "distal free limb segment of lower extremity zone of skin" EXACT []
synonym: "foot skin" EXACT []
synonym: "foot zone of skin" EXACT []
synonym: "hind limb autopod zone of skin" EXACT []
synonym: "hind limb distal free limb segment zone of skin" EXACT []
synonym: "hindlimb autopod zone of skin" EXACT []
synonym: "hindlimb distal free limb segment zone of skin" EXACT []
synonym: "inferior member autopod zone of skin" EXACT []
synonym: "inferior member distal free limb segment zone of skin" EXACT []
synonym: "lower extremity autopod zone of skin" EXACT []
synonym: "lower extremity distal free limb segment zone of skin" EXACT []
synonym: "skin of foot" EXACT []
synonym: "skin of hind-paw" NARROW []
synonym: "terminal segment of free lower limb zone of skin" EXACT []
synonym: "zone of skin of autopod of hind limb" EXACT []
synonym: "zone of skin of autopod of hindlimb" EXACT []
synonym: "zone of skin of autopod of inferior member" EXACT []
synonym: "zone of skin of autopod of lower extremity" EXACT []
synonym: "zone of skin of distal free limb segment of hind limb" EXACT []
synonym: "zone of skin of distal free limb segment of hindlimb" EXACT []
synonym: "zone of skin of distal free limb segment of inferior member" EXACT []
synonym: "zone of skin of distal free limb segment of lower extremity" EXACT []
synonym: "zone of skin of foot" EXACT []
synonym: "zone of skin of hind limb autopod" EXACT []
synonym: "zone of skin of hind limb distal free limb segment" EXACT []
synonym: "zone of skin of hindlimb autopod" EXACT []
synonym: "zone of skin of hindlimb distal free limb segment" EXACT []
synonym: "zone of skin of inferior member autopod" EXACT []
synonym: "zone of skin of inferior member distal free limb segment" EXACT []
synonym: "zone of skin of lower extremity autopod" EXACT []
synonym: "zone of skin of lower extremity distal free limb segment" EXACT []
synonym: "zone of skin of terminal segment of free lower limb" EXACT []
is_a: UBERON:0003532 ! hindlimb skin
is_a: UBERON:0015790 ! autopod skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0001515
name: thoracic aorta
def: "the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" []
synonym: "aorta thoracalis" RELATED []
synonym: "aorta thoracica" EXACT []
synonym: "pars thoracica aortae" RELATED []
synonym: "thoracic part of aorta" EXACT []
is_a: UBERON:0005800 ! section of aorta
intersection_of: UBERON:0005800 ! section of aorta
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0001519
name: skin of manus
def: "A zone of skin that is part of a manus [Automatically generated definition]." []
synonym: "hand skin" EXACT []
synonym: "manus skin" EXACT []
synonym: "skin of fore-paw" NARROW []
synonym: "skin of hand" EXACT []
is_a: UBERON:0003531 ! forelimb skin
is_a: UBERON:0015790 ! autopod skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0001529
name: brachiocephalic artery
def: "the short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery" []
synonym: "brachiocephalic trunk" EXACT []
synonym: "innominate" BROAD []
synonym: "innominate artery" EXACT []
synonym: "truncus brachiocephalicus" EXACT []
synonym: "truncus brachiocephalicus" RELATED []
is_a: UBERON:0004573 ! systemic artery
relationship: part_of UBERON:0007204 ! brachiocephalic vasculature

[Term]
id: UBERON:0001533
name: subclavian artery
def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta" []
synonym: "arteria subclavia" EXACT []
synonym: "arteria subclavia" RELATED []
synonym: "arterial tree of upper limb" EXACT []
synonym: "PA" RELATED []
synonym: "pectoral artery" EXACT []
synonym: "subclavian arterial tree" EXACT []
is_a: UBERON:0004573 ! systemic artery
relationship: develops_from UBERON:0002457 ! intersomitic artery
relationship: develops_from UBERON:0005622 ! right dorsal aorta

[Term]
id: UBERON:0001552
name: kidney arcuate artery
def: "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." []
synonym: "arcuate artery" BROAD []
synonym: "renal arcuate artery" EXACT []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0001554
name: skin of hip
def: "A zone of skin that is part of a hip region." []
synonym: "hip region zone of skin" EXACT []
synonym: "hip skin" EXACT []
synonym: "hip zone of skin" EXACT []
synonym: "regio coxae zone of skin" EXACT []
synonym: "zone of skin of hip" EXACT []
synonym: "zone of skin of hip region" EXACT []
synonym: "zone of skin of regio coxae" EXACT []
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001464 ! hip
relationship: part_of UBERON:0001464 ! hip

[Term]
id: UBERON:0001555
name: digestive tract
def: "A tube extending from the mouth to the anus." []
synonym: "alimentary canal" NARROW []
synonym: "alimentary tract" NARROW []
synonym: "digestive canal" RELATED []
synonym: "digestive tube" EXACT []
synonym: "enteric tract" EXACT []
synonym: "gut" BROAD []
synonym: "gut tube" RELATED []
is_a: UBERON:0000025 ! tube
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0001556
name: lower urinary tract
def: "Subdivision of urinary system which consists of the urinary bladder and the urethra." []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000477 ! anatomical cluster
relationship: has_part UBERON:0000057 ! urethra
relationship: has_part UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0001557
name: upper respiratory tract
def: "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000004 ! nose

[Term]
id: UBERON:0001558
name: lower respiratory tract
def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]" []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000170 ! pair of lungs

[Term]
id: UBERON:0001560
name: neck of organ
synonym: "organ neck" EXACT []
is_a: UBERON:0034944 ! zone of organ

[Term]
id: UBERON:0001575
name: extrinsic muscle of tongue
def: "A muscle organ that attaches the tongue to some other structure." []
synonym: "extrinsic lingual muscle" EXACT []
synonym: "extrinsic tongue muscle" EXACT []
is_a: UBERON:0000378 ! tongue muscle

[Term]
id: UBERON:0001576
name: intrinsic muscle of tongue
def: "The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII." []
synonym: "intrinsic lingual muscle" EXACT []
synonym: "intrinsic tongue muscle" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000378 ! tongue muscle
relationship: develops_from UBERON:0010059 ! hypoglossal cord
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0001577
name: facial muscle
def: "A muscle innervated by a facial nerve." []
synonym: "cranial-facial muscle" RELATED []
synonym: "cranio-facial muscle" RELATED []
synonym: "craniofacial muscle" RELATED []
synonym: "face muscle" EXACT []
synonym: "face muscle organ" EXACT []
synonym: "facial muscle" EXACT []
synonym: "facial muscle proper" EXACT []
synonym: "facial nerve innervated muscle" EXACT []
synonym: "facial nerve muscle" EXACT []
synonym: "mimetic muscles" RELATED []
synonym: "muscle of face" EXACT []
synonym: "muscle of facil expression" RELATED []
synonym: "muscle organ of face" EXACT []
synonym: "muscles of facial expression" RELATED []
synonym: "musculi faciei" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015789 ! cranial or facial muscle
relationship: develops_from UBERON:0003066 ! pharyngeal arch 2

[Term]
id: UBERON:0001605
name: ciliary muscle
def: "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." []
synonym: "Bowman`s muscles" RELATED []
synonym: "ciliaris" RELATED []
synonym: "musculus ciliaris" RELATED []
synonym: "musculus ciliarus" EXACT []
is_a: UBERON:0003386 ! smooth muscle of eye
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0011222 ! intra-ocular muscle
relationship: part_of UBERON:0001775 ! ciliary body

[Term]
id: UBERON:0001606
name: muscle of iris
def: "." []
synonym: "iris muscle" EXACT []
synonym: "iris muscle organ" EXACT []
synonym: "muscle organ of iris" EXACT []
is_a: UBERON:0011222 ! intra-ocular muscle
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0001607
name: sphincter pupillae
def: "A sphincter muscle that is part of the iris." []
synonym: "circular fibers" RELATED []
synonym: "constrictor pupillae" RELATED []
synonym: "iris constrictor" RELATED []
synonym: "iris constrictor muscle" RELATED []
synonym: "iris sphincter" RELATED []
synonym: "iris sphincter muscle" EXACT []
synonym: "M. sphincter pupillae" EXACT []
synonym: "m. sphincter pupillae" RELATED []
synonym: "musculus sphincter pupillae" EXACT []
synonym: "pupillary constrictor muscle" RELATED []
synonym: "pupillary sphincter" RELATED []
synonym: "pupillary sphincter muscle" RELATED []
synonym: "sphincter muscle of pupil" EXACT []
synonym: "sphincter pupillae" RELATED []
synonym: "sphincter pupillae muscle" RELATED []
synonym: "spincter pupillae" RELATED []
is_a: UBERON:0001606 ! muscle of iris
is_a: UBERON:0004234 ! iris smooth muscle
is_a: UBERON:0007521 ! smooth muscle sphincter
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0001769 ! iris
relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0001608
name: dilatator pupillae
def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." []
synonym: "dilator muscle of pupil" EXACT []
synonym: "dilator of pupil" EXACT []
synonym: "dilator pupillae" EXACT []
synonym: "dilator pupillae muscle" EXACT []
synonym: "dilator pupillae muscle" RELATED []
synonym: "iris dilator" RELATED []
synonym: "iris dilator muscle" EXACT []
synonym: "musculus dilatator pupillae" EXACT []
synonym: "musculus dilatator pupillae" RELATED []
synonym: "musculus dilator pupillae" RELATED []
synonym: "pupil dilator" RELATED []
synonym: "pupil dilator muscle" RELATED []
synonym: "pupillary dilator" RELATED []
synonym: "pupillary dilator muscle" EXACT []
synonym: "pupillary muscle" RELATED []
synonym: "radial muscle" RELATED []
synonym: "radial muscle of iris" EXACT []
synonym: "radiating fibers" RELATED []
is_a: UBERON:0004234 ! iris smooth muscle
relationship: develops_from UBERON:0002346 ! neurectoderm

[Term]
id: UBERON:0001621
name: coronary artery
def: "An artery that supplies the myocardium." []
synonym: "coronary arterial tree" EXACT []
synonym: "coronary vessel" RELATED []
is_a: UBERON:0003498 ! heart blood vessel
is_a: UBERON:0004573 ! systemic artery
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0001630
name: muscle organ
def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." []
synonym: "muscle" BROAD []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0005090 ! muscle structure
relationship: part_of UBERON:0001015 ! musculature

[Term]
id: UBERON:0001637
name: artery
def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." []
synonym: "arterial subtree" EXACT []
synonym: "arterial system" RELATED []
synonym: "arterial tree organ part" EXACT []
synonym: "arterial vessel" RELATED []
synonym: "arteries" EXACT []
is_a: UBERON:0003509 ! arterial blood vessel
relationship: part_of UBERON:0004572 ! arterial system

[Term]
id: UBERON:0001638
name: vein
def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." []
synonym: "vascular element" RELATED []
synonym: "vena" RELATED []
synonym: "venae" RELATED []
synonym: "venous subtree" BROAD []
synonym: "venous tree organ part" EXACT []
synonym: "venous vessel" BROAD []
is_a: UBERON:0003920 ! venous blood vessel

[Term]
id: UBERON:0001678
name: temporal bone
def: "the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" []
synonym: "os temporale" RELATED []
is_a: UBERON:0003462 ! facial bone
is_a: UBERON:0008193 ! pneumatized bone
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0001690
name: ear
def: "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." []
synonym: "auditory apparatus" RELATED []
synonym: "auris" RELATED []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0002105 ! vestibulo-auditory system

[Term]
id: UBERON:0001691
name: external ear
def: "Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO]." []
synonym: "auricular region" BROAD []
synonym: "auricular region of head" EXACT []
synonym: "auris externa" RELATED []
synonym: "outer ear" EXACT []
is_a: UBERON:0001444 ! subdivision of head
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0001690 ! ear

[Term]
id: UBERON:0001694
name: petrous part of temporal bone
def: "The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted]." []
synonym: "pars petrosa (os temporale)" EXACT []
synonym: "pars petrosa ossis temporalis" EXACT []
synonym: "petromastoid part of temporal bone" EXACT []
synonym: "petrosal" BROAD []
synonym: "petrosal bone" RELATED []
synonym: "petrous bone" RELATED []
synonym: "temporal bone petrous part" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005913 ! zone of bone organ
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: part_of UBERON:0001678 ! temporal bone
relationship: part_of UBERON:0002517 ! basicranium

[Term]
id: UBERON:0001703
name: neurocranium
def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." []
synonym: "brain box" EXACT []
synonym: "brain case" RELATED []
synonym: "brain pan" RELATED []
synonym: "braincase" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0011158 ! primary subdivision of skull
relationship: develops_from UBERON:0004761 ! cartilaginous neurocranium
relationship: part_of UBERON:0003128 ! cranium

[Term]
id: UBERON:0001708
name: jaw skeleton
def: "Subdivision of skeleton which includes upper and lower jaw skeletons." []
synonym: "anterior splanchnocranium" RELATED []
synonym: "jaw" EXACT []
synonym: "jaw cartilage" EXACT []
synonym: "jaws" RELATED []
synonym: "mandibular arch" RELATED []
synonym: "mandibular arch skeleton" EXACT []
synonym: "oral jaw skeleton" RELATED []
synonym: "pharyngeal arch 1 skeleton" RELATED []
synonym: "visceral arch 1" RELATED []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0011156 ! facial skeleton
relationship: part_of UBERON:0011595 ! jaw region

[Term]
id: UBERON:0001710
name: lower jaw region
def: "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." []
synonym: "lower part of mouth" RELATED []
synonym: "mandibular part of mouth" EXACT []
synonym: "mandibular series" RELATED []
is_a: UBERON:0000475 ! organism subdivision
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005867 ! mandibular prominence

[Term]
id: UBERON:0001711
name: eyelid
def: "A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane" []
synonym: "blephara" RELATED []
synonym: "blepharon" EXACT []
synonym: "eye lid" EXACT []
synonym: "palpebra" EXACT []
synonym: "palpebrae" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0001714
name: cranial ganglion
def: "the groups of nerve cell bodies associated with the twelve cranial nerves" []
synonym: "cranial ganglia" RELATED []
synonym: "cranial ganglion" EXACT []
synonym: "cranial ganglion part of peripheral nervous system" EXACT []
synonym: "cranial ganglion/nerve" EXACT []
synonym: "cranial nerve ganglion" EXACT []
synonym: "cranial neural ganglion" EXACT []
synonym: "cranial neural tree organ ganglion" EXACT []
synonym: "ganglion of cranial nerve" EXACT []
synonym: "ganglion of cranial neural tree organ" EXACT []
synonym: "head ganglion" RELATED []
synonym: "presumptive cranial ganglia" RELATED []
is_a: UBERON:0000045 ! ganglion
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0001723
name: tongue
def: "A muscular organ in the floor of the mouth." []
synonym: "glossus" RELATED []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0013765 ! digestive system element
relationship: develops_from UBERON:0008814 ! pharyngeal arch system
relationship: part_of UBERON:0000165 ! mouth
relationship: part_of UBERON:0001033 ! gustatory system

[Term]
id: UBERON:0001728
name: nasopharynx
def: "the section of the pharynx that lies above the soft palate" []
synonym: "epipharynx" RELATED []
synonym: "nasal part of pharynx" EXACT []
synonym: "Nasenrachenraum" RELATED []
synonym: "pars nasalis pharyngis" RELATED []
synonym: "rhinopharynx" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001557 ! upper respiratory tract

[Term]
id: UBERON:0001735
name: tonsillar ring
def: "the circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils" []
synonym: "anulus lymphoideus pharyngis" EXACT []
synonym: "oropharyngeal lymphoid tissue" EXACT []
synonym: "pharyngeal lymphatic ring" EXACT []
synonym: "pharyngeal lymphoid ring" EXACT []
synonym: "Waldeyer's ring" EXACT []
synonym: "Waldeyer's tonsillar ring" EXACT []
is_a: UBERON:0001962 ! gut-associated lymphoid tissue
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0001744
name: lymphoid tissue
def: "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." []
synonym: "lymphatic tissue" EXACT []
synonym: "lymphocytic tissue" EXACT []
is_a: UBERON:0034769 ! lymphomyeloid tissue
relationship: part_of UBERON:0002193 ! hemolymphoid system
relationship: part_of UBERON:0002465 ! lymphoid system

[Term]
id: UBERON:0001745
name: secondary nodular lymphoid tissue
def: "A lymphoid follicle that contains a germinal center." []
synonym: "peripheral lymphoid tissue" EXACT []
synonym: "secondary lymphoid nodule" EXACT []
synonym: "secondary lymphoid tissue" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000444 ! lymphoid follicle
intersection_of: UBERON:0000444 ! lymphoid follicle
intersection_of: has_part UBERON:0010754 ! germinal center
relationship: develops_from UBERON:0010422 ! primary nodular lymphoid tissue
relationship: has_part UBERON:0010754 ! germinal center

[Term]
id: UBERON:0001746
name: capsule of thyroid gland
synonym: "capsula fibrosa glandulae thyroideae" EXACT []
synonym: "fibrous capsule of thyroid gland" EXACT []
synonym: "thyroid capsule" EXACT []
synonym: "thyroid gland capsule" EXACT []
is_a: UBERON:0003893 ! capsule
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0003893 ! capsule
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0001747
name: parenchyma of thyroid gland
def: "A parenchyma that is part of a thyroid follicle [Automatically generated definition]." []
synonym: "parenchyma glandulae thyroideae" RELATED []
synonym: "parenchyma of thyroid" EXACT []
synonym: "parenchyma of thyroid follicle" EXACT []
synonym: "parenchyma of thyroid gland follicle" EXACT []
synonym: "thyroid follicle parenchyma" EXACT []
synonym: "thyroid gland follicle parenchyma" EXACT []
synonym: "thyroid gland parenchyma" EXACT []
synonym: "thyroid parenchyma" EXACT []
is_a: UBERON:0000353 ! parenchyma
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0001749
name: parenchyma of parathyroid gland
def: "A parenchyma that is part of a parathyroid gland [Automatically generated definition]." []
synonym: "parathyroid gland parenchyma" EXACT []
synonym: "parathyroid parenchyma" EXACT []
synonym: "parenchyma of parathyroid" EXACT []
is_a: UBERON:0000353 ! parenchyma
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: part_of UBERON:0001132 ! parathyroid gland

[Term]
id: UBERON:0001750
name: lacrimal apparatus
def: "A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta." []
synonym: "apparatus lacrimalis" EXACT []
synonym: "lacrimal drainage system" RELATED []
synonym: "lacrymal system" EXACT []
synonym: "nasolacrimal drainage system" RELATED []
synonym: "nasolacrimal system" RELATED []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0010409 ! ocular surface region
relationship: part_of UBERON:0035639 ! ocular adnexa

[Term]
id: UBERON:0001751
name: dentine
def: "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." []
synonym: "dentin" EXACT []
synonym: "dentine of tooth" EXACT []
synonym: "predentin" NARROW []
is_a: UBERON:0010365 ! odontoid tissue
is_a: UBERON:4000013 ! mineralized skeletal tissue

[Term]
id: UBERON:0001752
name: enamel
def: "A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP]." []
synonym: "enamel of tooth" EXACT []
synonym: "enamel tissue" EXACT []
synonym: "enameloid" RELATED []
synonym: "tooth enamel" EXACT []
is_a: UBERON:0010365 ! odontoid tissue
is_a: UBERON:4000013 ! mineralized skeletal tissue
relationship: develops_from UBERON:0011588 ! pre-enamel

[Term]
id: UBERON:0001753
name: cementum
def: "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." []
synonym: "bone of attachment" RELATED []
synonym: "cement" EXACT []
synonym: "cement of tooth" EXACT []
synonym: "cementum" EXACT []
synonym: "cementum of tooth" EXACT []
is_a: UBERON:0010365 ! odontoid tissue

[Term]
id: UBERON:0001754
name: dental pulp
def: "The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP]." []
synonym: "dental pulp cell" RELATED []
synonym: "pulp of tooth" EXACT []
synonym: "tooth pulp" EXACT []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011825 ! loose connective tissue
relationship: develops_from UBERON:0001763 ! odontogenic papilla
relationship: part_of UBERON:0001091 ! calcareous tooth

[Term]
id: UBERON:0001756
name: middle ear
def: "The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO]." []
synonym: "auris media" RELATED []
is_a: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0001690 ! ear

[Term]
id: UBERON:0001757
name: pinna
def: "The part of the ear that projects from the head, connecting to the external acoustic meatus." []
synonym: "auricle" EXACT []
synonym: "auricle of ear" EXACT []
synonym: "auricle of external ear" EXACT []
synonym: "auricula" EXACT []
synonym: "auricula (auris externa)" EXACT []
synonym: "pinna of ear" EXACT []
synonym: "pinnae" RELATED []
is_a: UBERON:0001444 ! subdivision of head
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0006208 ! auditory hillocks
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0001758
name: periodontium
def: "The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO]." []
synonym: "paradentium" RELATED []
synonym: "periodontal ligament" RELATED []
synonym: "periodontal membrane" RELATED []
synonym: "tooth supporting structure" RELATED []
is_a: UBERON:0000479 ! tissue
relationship: part_of UBERON:0003672 ! dentition

[Term]
id: UBERON:0001763
name: odontogenic papilla
def: "Tissue of the developing tooth. It is composed of pre-odontoblast and undiffentiated mesnchyme cells and connects to the basal lamina[ZFA]. The dental papilla is a condensation of ectomesenchymal cells called odontoblasts, seen in histologic sections of a developing tooth. It lies below a cellular aggregation known as the enamel organ. The dental papilla appears after 8-10 weeks intra uteral life. The dental papilla gives rise to the dentin and pulp of a tooth. The enamel organ, dental papilla, and dental follicle together forms one unit, called the tooth germ. This is of importance because all the tissues of a tooth and its supporting structures form from these distinct cellular aggregations." []
synonym: "dental papilla" RELATED []
synonym: "dentinal papilla" RELATED []
synonym: "dermal papilla" RELATED []
synonym: "odontogenic condensation" EXACT []
synonym: "papilla dentis" RELATED []
synonym: "pharyngeal tooth mesenchyme" NARROW []
synonym: "tooth mesenchyme" RELATED []
is_a: UBERON:0003856 ! odontogenic mesenchyme
is_a: UBERON:0005856 ! developing mesenchymal condensation
relationship: develops_from UBERON:0003856 ! odontogenic mesenchyme
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: UBERON:0001765
name: mammary duct
def: "Epithelial tube that transports milk[GO]." []
synonym: "ductus lactiferi" RELATED []
synonym: "galactophorous duct" RELATED []
synonym: "galactophorous tubule" RELATED []
synonym: "lactiferous duct" EXACT []
synonym: "lactiferous gland duct" EXACT []
synonym: "lactiferous tubule" RELATED []
synonym: "mammary gland duct" EXACT []
synonym: "mammilary duct" RELATED []
is_a: UBERON:0000058 ! duct
is_a: UBERON:0003244 ! epithelium of mammary gland
is_a: UBERON:0003914 ! epithelial tube
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0001766
name: anterior chamber of eyeball
def: "the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" []
synonym: "anterior chamber" EXACT []
synonym: "anterior chamber of eye" EXACT []
synonym: "camera anterior" EXACT []
synonym: "camera anterior bulbi" RELATED []
synonym: "camera anterior bulbi oculi" RELATED []
synonym: "camera oculi anterior" RELATED []
synonym: "eye anterior chamber" EXACT []
is_a: UBERON:0006311 ! chamber of eyeball
relationship: part_of UBERON:0001801 ! anterior segment of eyeball

[Term]
id: UBERON:0001768
name: uvea
def: "the pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." []
synonym: "pars iridica retinae" RELATED []
synonym: "tunica vasculatis oculi" RELATED []
synonym: "tunica vasculosa bulbi" RELATED []
synonym: "tunica vasculosa of eyeball" EXACT []
synonym: "uvea" EXACT []
synonym: "uveal tract" EXACT []
synonym: "vascular layer of eyeball" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0001769 ! iris
relationship: has_part UBERON:0001775 ! ciliary body
relationship: has_part UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001801 ! anterior segment of eyeball

[Term]
id: UBERON:0001769
name: iris
def: "the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" []
synonym: "anterior uvea" RELATED []
synonym: "irides" RELATED []
synonym: "irises" RELATED []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0004128 ! optic vesicle
relationship: part_of UBERON:0011892 ! anterior uvea

[Term]
id: UBERON:0001770
name: lacrimal canaliculus
def: "The part of the lacrimal duct that connects the lacrimal punctum to the lacrimal sac." []
synonym: "canaliculus lacrimalis" RELATED []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001850 ! lacrimal drainage system

[Term]
id: UBERON:0001772
name: corneal epithelium
def: "the smooth stratified squamous epithelium that covers the outer surface of the cornea" []
synonym: "anterior corneal epithelium" EXACT []
synonym: "anterior endothelium of cornea" RELATED []
synonym: "cornea epithelial tissue" EXACT []
synonym: "cornea epithelium" EXACT []
synonym: "e. anterius corneae" RELATED []
synonym: "endothelium anterius corneae" RELATED []
synonym: "endothelium camerae anterioris bulbi" RELATED []
synonym: "endothelium corneale" RELATED []
synonym: "epithelial tissue of cornea" EXACT []
synonym: "epithelium anterius (cornea)" EXACT []
synonym: "epithelium anterius corneae" EXACT []
synonym: "epithelium corneæ anterior layer" EXACT []
synonym: "epithelium of cornea" EXACT []
synonym: "epithelium posterius corneae" RELATED []
synonym: "external epithelium of cornea" EXACT []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0015808 ! eye epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm

[Term]
id: UBERON:0001773
name: sclera
def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." []
synonym: "scleral capsule" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0003314 ! eye mesenchyme
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0012430 ! tunica fibrosa of eyeball

[Term]
id: UBERON:0001774
name: skeletal muscle of trunk
def: "A skeletal muscle organ that is part of the trunk region." []
synonym: "body musculature" EXACT []
synonym: "muscle of trunk" EXACT []
synonym: "muscle organ of torso" EXACT []
synonym: "muscle organ of trunk" EXACT []
synonym: "torso muscle organ" EXACT []
synonym: "trunk muscle" EXACT []
synonym: "trunk muscle organ" EXACT []
synonym: "trunk musculature" EXACT []
is_a: UBERON:0005177 ! trunk region element
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0004479 ! musculature of trunk

[Term]
id: UBERON:0001775
name: ciliary body
def: "the thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes" []
synonym: "anterior uvea" RELATED []
synonym: "ciliary bodies" RELATED []
synonym: "corpus ciliare" RELATED []
synonym: "ocular ciliary body" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: has_part UBERON:0001605 ! ciliary muscle
relationship: has_part UBERON:0010427 ! ciliary processes
relationship: part_of UBERON:0011892 ! anterior uvea

[Term]
id: UBERON:0001776
name: optic choroid
def: "vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." []
synonym: "chorioid" RELATED []
synonym: "choroid" EXACT []
synonym: "choroid coat" EXACT []
synonym: "choroidea" EXACT []
synonym: "choroidea" RELATED []
synonym: "eye choroid" EXACT []
synonym: "optic choroid" RELATED []
synonym: "posterior uvea" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002203 ! vasculature of eye
disjoint_from: UBERON:0011892 ! anterior uvea
relationship: part_of UBERON:0001768 ! uvea
relationship: part_of UBERON:0019207 ! chorioretinal region

[Term]
id: UBERON:0001777
name: substantia propria of cornea
def: "the lamellated connective tissue of the cornea between the Bowman and Descemet membranes" []
synonym: "corneal stroma" EXACT []
synonym: "stroma of cornea" EXACT []
synonym: "substantia propria" BROAD []
synonym: "substantia propria corneae" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: UBERON:0001778
name: ciliary epithelium
def: "A double layer covering the ciliary body that produces aqueous humor." []
synonym: "ciliary body epithelium" EXACT []
synonym: "epithelium of ciliary body" EXACT []
synonym: "ocular ciliary epithelium" EXACT []
is_a: UBERON:0000488 ! atypical epithelium
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001775 ! ciliary body
relationship: part_of UBERON:0001775 ! ciliary body

[Term]
id: UBERON:0001779
name: iris stroma
def: "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." []
synonym: "iridial stroma" EXACT []
synonym: "stroma of iris" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0001780
name: spinal nerve
def: "the any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]" []
synonym: "backbone nerve" EXACT []
synonym: "nerve of backbone" EXACT []
synonym: "nerve of spinal column" EXACT []
synonym: "nerve of spine" EXACT []
synonym: "nerve of vertebral column" EXACT []
synonym: "nervi spinales" RELATED []
synonym: "spinal column nerve" EXACT []
synonym: "spinal nerve tree" EXACT []
synonym: "spinal nerves" RELATED []
synonym: "spine nerve" EXACT []
synonym: "vertebral column nerve" EXACT []
is_a: UBERON:0001021 ! nerve
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0001781
name: layer of retina
def: "Any of the layers that make up the retina[MP]." []
synonym: "retina layer" EXACT []
synonym: "retina neuronal layer" EXACT []
synonym: "retinal layer" EXACT []
synonym: "retinal neuronal layer" EXACT []
is_a: UBERON:0022303 ! nervous system cell part layer
relationship: part_of UBERON:0000966 ! retina

[Term]
id: UBERON:0001782
name: pigmented layer of retina
def: "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." []
synonym: "epithelium, retinal pigment" RELATED []
synonym: "outer pigmented layer of retina" EXACT []
synonym: "p. pigmentosa retinae" RELATED []
synonym: "pigment epithelium of retina" EXACT []
synonym: "pigmented epithelium" RELATED []
synonym: "pigmented retina" RELATED []
synonym: "pigmented retina epithelium" EXACT []
synonym: "pigmented retinal epithelium" EXACT []
synonym: "PRE" RELATED []
synonym: "retinal pigment epithelium" EXACT []
synonym: "retinal pigment layer" RELATED []
synonym: "retinal pigmented epithelium" EXACT []
synonym: "RPE" RELATED []
synonym: "stratum pigmentosa retinae" RELATED []
synonym: "stratum pigmentosum (retina)" EXACT []
synonym: "stratum pigmentosum retinae" EXACT []
is_a: UBERON:0000957 ! lamina
is_a: UBERON:0001781 ! layer of retina
is_a: UBERON:0015808 ! eye epithelium

[Term]
id: UBERON:0001785
name: cranial nerve
def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." []
synonym: "cranial nerves" RELATED []
synonym: "cranial neural tree organ" EXACT []
synonym: "nervus cranialis" RELATED []
is_a: UBERON:0011779 ! nerve of head region
is_a: UBERON:0034713 ! cranial neuron projection bundle

[Term]
id: UBERON:0001791
name: inner nuclear layer of retina
def: "Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia)." []
synonym: "INL" NARROW []
synonym: "inner nuclear layer" EXACT []
synonym: "intermediate cell layer" EXACT []
synonym: "layer of inner granules" RELATED []
synonym: "neural retina inner nuclear layer" EXACT []
synonym: "retina inner nuclear layer" EXACT []
synonym: "retina, inner nuclear layer" RELATED []
synonym: "retinal inner nuclear layer" EXACT []
synonym: "stratum nucleare internum" EXACT []
synonym: "stratum nucleare internum retinae" EXACT []
is_a: UBERON:0001781 ! layer of retina
relationship: part_of UBERON:0003902 ! retinal neural layer

[Term]
id: UBERON:0001800
name: sensory ganglion
def: "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." []
synonym: "ganglion sensorium" EXACT []
is_a: UBERON:0000045 ! ganglion

[Term]
id: UBERON:0001801
name: anterior segment of eyeball
def: "any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)" []
synonym: "anterior eye segment" EXACT []
synonym: "anterior segment eye" EXACT []
synonym: "anterior segment of eye" EXACT []
synonym: "anterior segment of the eye" EXACT []
synonym: "eye anterior segment" EXACT []
synonym: "segmentum anterius (bulbus oculi)" EXACT []
synonym: "segmentum anterius bulbi oculi" RELATED []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004121 ! ectoderm-derived structure
disjoint_from: UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0010230 ! eyeball of camera-type eye

[Term]
id: UBERON:0001802
name: posterior segment of eyeball
def: "any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)" []
synonym: "eye posterior segment" EXACT []
synonym: "posterior eye segment" EXACT []
synonym: "posterior segment eye" EXACT []
synonym: "posterior segment of eye" EXACT []
synonym: "posterior segment of the eye" EXACT []
synonym: "segmentum posterius (bulbus oculi)" EXACT []
synonym: "segmentum posterius bulbi oculi" RELATED []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0010230 ! eyeball of camera-type eye

[Term]
id: UBERON:0001803
name: epithelium of lens
def: "A layer of epithelial cells that is part of the eye." []
synonym: "epithelial tissue of eye lens" EXACT []
synonym: "epithelial tissue of lens" EXACT []
synonym: "epithelium lentis" EXACT []
synonym: "epithelium of eye lens" EXACT []
synonym: "eye lens epithelial tissue" EXACT []
synonym: "eye lens epithelium" EXACT []
synonym: "lens epithelial tissue" EXACT []
synonym: "lens epithelium" EXACT []
is_a: UBERON:0000484 ! simple cuboidal epithelium
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000965 ! lens of camera-type eye
relationship: part_of UBERON:0000965 ! lens of camera-type eye

[Term]
id: UBERON:0001805
name: autonomic ganglion
def: "ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." []
synonym: "autonomic nervous system ganglion" EXACT []
synonym: "ganglion autonomicum" RELATED []
synonym: "ganglion of autonomic nervous system" EXACT []
synonym: "ganglion of visceral nervous system" EXACT []
synonym: "visceral nervous system ganglion" EXACT []
is_a: UBERON:0003338 ! ganglion of peripheral nervous system
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 ! autonomic nervous system

[Term]
id: UBERON:0001811
name: conjunctiva
def: "the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball" []
synonym: "conjunctivae" EXACT []
synonym: "conjunctivas" EXACT []
synonym: "tunica conjunctiva" EXACT []
synonym: "wall of conjunctival sac" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0005908 ! conjunctival sac
relationship: part_of UBERON:0010409 ! ocular surface region

[Term]
id: UBERON:0001817
name: lacrimal gland
def: "The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP]." []
synonym: "glandula lacrimalis" EXACT []
synonym: "glandula praeorbitalis" RELATED []
synonym: "lacrimal-preorbital gland" EXACT []
synonym: "preorbital gland" RELATED []
synonym: "tear gland" RELATED []
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004859 ! eye gland
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015154 ! lateral gland of orbital region
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001750 ! lacrimal apparatus
relationship: develops_from UBERON:0022284 ! lacrimal gland bud
relationship: part_of UBERON:0001750 ! lacrimal apparatus
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0001820
name: sweat gland
def: "any of the coil glands of the skin that secrete sweat" []
synonym: "glandula sudorifera" RELATED []
synonym: "sudoriferous gland" RELATED []
synonym: "sudoriparous gland" RELATED []
is_a: UBERON:0007771 ! epidermis gland
is_a: UBERON:0019319 ! exocrine gland of integumental system
relationship: develops_from UBERON:0005089 ! sweat gland placode
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0001821
name: sebaceous gland
def: "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." []
synonym: "glandula sebacea" RELATED []
synonym: "glandula sebaceae" RELATED []
synonym: "sebaceous follicle" RELATED []
is_a: UBERON:0007771 ! epidermis gland
is_a: UBERON:0012344 ! holocrine gland
is_a: UBERON:0019319 ! exocrine gland of integumental system
relationship: develops_from UBERON:0005088 ! sebaceous gland placode
relationship: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0002330 ! exocrine system
relationship: part_of UBERON:0011932 ! pilosebaceous unit

[Term]
id: UBERON:0001823
name: nasal cartilage
def: "One of the cartilage structures in the nose that provide form and support[WP]." []
synonym: "cartilage of nose" EXACT []
is_a: UBERON:0002418 ! cartilage tissue
is_a: UBERON:0003566 ! head connective tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0007844 ! cartilage element
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0000004 ! nose

[Term]
id: UBERON:0001826
name: nasal cavity mucosa
def: "The mucous membrane that lines the nasal cavity[MP]." []
synonym: "mucosa of nose" EXACT []
synonym: "mucous membrane of nose" EXACT []
synonym: "nasal mucosa" RELATED []
synonym: "tunica mucosa nasalis" EXACT []
synonym: "tunica mucosa nasi" EXACT []
is_a: UBERON:0000379 ! tracheal mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0015788 ! olfactory apparatus chamber
relationship: part_of UBERON:0015788 ! olfactory apparatus chamber

[Term]
id: UBERON:0001828
name: gingiva
def: "The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001]." []
synonym: "gingival mucosa" RELATED []
synonym: "gum" EXACT []
synonym: "gum tissue" EXACT []
synonym: "gums" EXACT []
is_a: UBERON:0003729 ! mouth mucosa
relationship: part_of UBERON:0003729 ! mouth mucosa
relationship: part_of UBERON:0011595 ! jaw region

[Term]
id: UBERON:0001837
name: duct of salivary gland
def: "The duct of a salivary gland." []
synonym: "salivary duct" EXACT []
synonym: "salivary gland duct" EXACT []
synonym: "secretory duct" RELATED []
is_a: UBERON:0003928 ! digestive system duct
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland

[Term]
id: UBERON:0001839
name: bony labyrinth
def: "A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." []
synonym: "labyrinthus osseus" RELATED []
synonym: "osseous labyrinth" EXACT []
synonym: "osseus labyrinth" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0001694 ! petrous part of temporal bone
relationship: part_of UBERON:0001846 ! internal ear
relationship: part_of UBERON:0004681 ! vestibular system

[Term]
id: UBERON:0001840
name: semicircular canal
def: "One of three half-circular, interconnected tubes located inside each ear[WP]." []
synonym: "canalis semicircularis" RELATED []
synonym: "ductus semicirculares" RELATED []
synonym: "scc" RELATED []
synonym: "semicircular canals" EXACT []
synonym: "semicircular ducts" RELATED []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001846 ! internal ear
relationship: part_of UBERON:0001849 ! membranous labyrinth

[Term]
id: UBERON:0001844
name: cochlea
def: "the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified]." []
synonym: "cochleae" RELATED []
synonym: "cochlear duct" RELATED []
synonym: "cochlear organ" RELATED []
synonym: "cochlear part of bony labyrinth" EXACT []
synonym: "lagena" EXACT []
synonym: "lagenas" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0001839 ! bony labyrinth

[Term]
id: UBERON:0001846
name: internal ear
def: "Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation." []
synonym: "auris interna" RELATED []
synonym: "inner ear" EXACT []
synonym: "labyrinth" RELATED []
synonym: "otocyst" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0034921 ! multi organ part structure
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001690 ! ear

[Term]
id: UBERON:0001848
name: auricular cartilage
def: "cartilage of the pinna and much of the external ear canal." []
synonym: "cartilage of pinna" EXACT []
synonym: "pinna cartilage" EXACT []
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0034944 ! zone of organ
intersection_of: UBERON:0034944 ! zone of organ
intersection_of: part_of UBERON:0001757 ! pinna
intersection_of: part_of UBERON:0001867 ! cartilage of external ear
relationship: part_of UBERON:0001757 ! pinna
relationship: part_of UBERON:0001867 ! cartilage of external ear

[Term]
id: UBERON:0001849
name: membranous labyrinth
def: "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP]" []
synonym: "labyrinthus membranaceus" EXACT []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005641 ! otocyst epithelium
relationship: part_of UBERON:0001846 ! internal ear

[Term]
id: UBERON:0001850
name: lacrimal drainage system
def: "A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct." []
synonym: "tear duct" RELATED []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001750 ! lacrimal apparatus

[Term]
id: UBERON:0001851
name: cortex
def: "Outermost layer of an organ[WP]." []
synonym: "cortex" EXACT []
synonym: "cortex of organ" EXACT []
is_a: UBERON:0000064 ! organ part

[Term]
id: UBERON:0001853
name: utricle of membranous labyrinth
def: "the larger of the two otolith organs in the vestibule" []
synonym: "membranous labyrinth utricle" EXACT []
synonym: "utricle" EXACT []
synonym: "utriculus" EXACT []
synonym: "utriculus (labyrinthus vestibularis)" EXACT []
is_a: UBERON:0002518 ! otolith organ

[Term]
id: UBERON:0001854
name: saccule of membranous labyrinth
def: "the smaller of the two otolith organs in the vestibule" []
synonym: "membranous labyrinth saccule" EXACT []
synonym: "saccule" EXACT []
synonym: "sacculus" EXACT []
synonym: "sacculus" RELATED []
synonym: "sacculus (labyrinthus vestibularis)" EXACT []
is_a: UBERON:0002518 ! otolith organ

[Term]
id: UBERON:0001855
name: cochlear duct of membranous labyrinth
def: "An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." []
synonym: "cochlea duct" EXACT []
synonym: "cochlear aqueduct" RELATED []
synonym: "cochlear duct" EXACT []
synonym: "ductus cochlearis" RELATED []
synonym: "membranous cochlea" RELATED []
synonym: "Reissner's canal" EXACT []
synonym: "Reissners canal" EXACT []
synonym: "scala media" RELATED []
synonym: "scala medias" EXACT []
synonym: "scala of Loewenberg" RELATED []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002499 ! cochlear labyrinth

[Term]
id: UBERON:0001856
name: semicircular duct
def: "Any of the three loop-shaped membranous inner tubular parts of the semicircular canals that are about one-fourth the diameter of the corresponding outer bony canals, that communicate at each end with the utricle, and that have near one end an expanded ampulla containing an area of sensory epithelium" []
synonym: "ductus semicirculares" RELATED []
synonym: "membranous semicircular canal" RELATED []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001840 ! semicircular canal
relationship: part_of UBERON:0001862 ! vestibular labyrinth

[Term]
id: UBERON:0001862
name: vestibular labyrinth
def: "The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals." []
synonym: "inner ear vestibular component" EXACT []
synonym: "labyrinthus vestibularis" RELATED []
synonym: "vestibular apparatus" RELATED []
synonym: "vestibular component" BROAD []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001849 ! membranous labyrinth

[Term]
id: UBERON:0001867
name: cartilage of external ear
def: "A cartilage that is part of a external ear [Automatically generated definition]." []
synonym: "external ear cartilage" EXACT []
is_a: UBERON:0007844 ! cartilage element
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0001691 ! external ear
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0001868
name: skin of chest
def: "A zone of skin that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region zone of skin" EXACT []
synonym: "anterolateral part of thorax zone of skin" EXACT []
synonym: "chest skin" EXACT []
synonym: "chest zone of skin" EXACT []
synonym: "front of thorax zone of skin" EXACT []
synonym: "zone of skin of anterior chest" EXACT []
synonym: "zone of skin of anterior part of thorax" EXACT []
synonym: "zone of skin of anterior thoracic region" EXACT []
synonym: "zone of skin of anterolateral part of thorax" EXACT []
synonym: "zone of skin of chest" EXACT []
synonym: "zone of skin of front of thorax" EXACT []
synonym: "zone of skin of pectoral part of chest" RELATED []
is_a: UBERON:0001418 ! skin of thorax
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0001869
name: cerebral hemisphere
def: "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]" []
synonym: "cerebrum" RELATED []
synonym: "hemisphere" RELATED []
synonym: "Hemispheric regions" RELATED []
synonym: "hemispherium cerebri" RELATED []
synonym: "medial amygdalar nucleus" RELATED []
synonym: "nucleus amygdaloideus medialis" RELATED []
synonym: "nucleus medialis amygdalae" RELATED []
synonym: "telencephalic vesicle" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0001870
name: frontal cortex
def: "Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified]." []
synonym: "cortex of frontal lobe" EXACT []
synonym: "frontal lobe cortex" EXACT []
synonym: "frontal neocortex" RELATED []
synonym: "gray matter of frontal lobe" EXACT []
synonym: "grey matter of frontal lobe" EXACT []
is_a: UBERON:0016529 ! cortex of cerebral lobe
intersection_of: UBERON:0016529 ! cortex of cerebral lobe
intersection_of: part_of UBERON:0016525 ! frontal lobe
relationship: part_of UBERON:0016525 ! frontal lobe

[Term]
id: UBERON:0001885
name: dentate gyrus of hippocampal formation
def: "Part of the hippocampal formation forming a 'V' or 'U' shaped structure with the opening bounded by hippocampal area CA3. It consists of 3 layers from superficial to deep: molecular, granule cell and polymorphic or hilar layer." []
synonym: "area dentata" EXACT []
synonym: "dentate area" RELATED []
synonym: "dentate area (dentate gyrus)" EXACT []
synonym: "dentate gyrus" EXACT []
synonym: "fascia dentata" NARROW []
synonym: "gyrus dentatus" RELATED []
synonym: "hippocampal dentate gyrus" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002421 ! hippocampal formation

[Term]
id: UBERON:0001886
name: choroid plexus
def: "A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces." []
synonym: "chorioid plexus" EXACT []
synonym: "choroid plexus of cerebral hemisphere" RELATED []
synonym: "CP" BROAD []
synonym: "plexus choroideus" EXACT []
synonym: "plexus choroideus" RELATED []
synonym: "ventricular choroid plexus" RELATED []
is_a: UBERON:0003947 ! brain ventricle/choroid plexus
is_a: UBERON:0005629 ! vascular plexus
is_a: UBERON:0006876 ! vasculature of organ
relationship: part_of UBERON:0004086 ! brain ventricle
relationship: part_of UBERON:0005283 ! tela choroidea

[Term]
id: UBERON:0001890
name: forebrain
def: "The most anterior region the brain including both the telencephalon and diencephalon." []
synonym: "FB" BROAD []
synonym: "prosencephalon" RELATED []
is_a: UBERON:0002616 ! regional part of brain
relationship: develops_from UBERON:0003080 ! anterior neural tube
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0001891
name: midbrain
def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." []
synonym: "MB" BROAD []
synonym: "mesencephalon" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0001893
name: telencephalon
def: "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." []
synonym: "cerebrum" EXACT []
synonym: "endbrain" EXACT []
synonym: "supratentorial region" BROAD []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0001894
name: diencephalon
def: "The division of the forebrain that develops from the foremost primary cerebral vesicle." []
synonym: "between brain" EXACT []
synonym: "betweenbrain" RELATED []
synonym: "DiE" BROAD []
synonym: "diencephalon" RELATED []
synonym: "interbrain" EXACT []
synonym: "mature diencephalon" EXACT []
synonym: "thalamencephalon" EXACT []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0001895
name: metencephalon
def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." []
synonym: "epencephalon" BROAD []
synonym: "epencephalon-2" EXACT []
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0001896
name: medulla oblongata
def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." []
synonym: "bulb" BROAD []
synonym: "bulbus" EXACT []
synonym: "medulla" BROAD []
synonym: "medulla oblonzata" RELATED []
synonym: "metepencephalon" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0005290 ! myelencephalon

[Term]
id: UBERON:0001897
name: dorsal plus ventral thalamus
def: "Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87)." []
synonym: "Th" BROAD []
synonym: "thalamencephalon" RELATED []
synonym: "thalami" RELATED []
synonym: "thalamus" BROAD []
synonym: "thalamus opticus" RELATED []
synonym: "wider thalamus" EXACT []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0010225 ! thalamic complex

[Term]
id: UBERON:0001898
name: hypothalamus
def: "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." []
synonym: "Hy" BROAD []
synonym: "hypothalamus" RELATED []
synonym: "preoptico-hypothalamic area" EXACT []
synonym: "preoptico-hypothalamic region" EXACT []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0000349 ! limbic system
relationship: part_of UBERON:0010225 ! thalamic complex

[Term]
id: UBERON:0001899
name: epithalamus
def: "Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346." []
synonym: "epithalamus" RELATED []
synonym: "ETh" BROAD []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus

[Term]
id: UBERON:0001901
name: epithelium of trachea
def: "the epithelial lining of the trachea which contains numerous ciliated cells" []
synonym: "epithelial tissue of trachea" EXACT []
synonym: "epithelial tissue of windpipe" EXACT []
synonym: "epithelium of windpipe" EXACT []
synonym: "trachea epithelial tissue" EXACT []
synonym: "trachea epithelium" EXACT []
synonym: "tracheal epithelium" EXACT []
synonym: "windpipe epithelial tissue" EXACT []
synonym: "windpipe epithelium" EXACT []
is_a: UBERON:0004815 ! lower respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from UBERON:0003258 ! endoderm of foregut
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0001902
name: epithelium of small intestine
def: "An epithelium that is part of a small intestine [Automatically generated definition]." []
synonym: "epithelial tissue of small bowel" EXACT []
synonym: "epithelial tissue of small intestine" EXACT []
synonym: "epithelium of small bowel" EXACT []
synonym: "mid intestine epithelium" EXACT []
synonym: "small bowel epithelial tissue" EXACT []
synonym: "small bowel epithelium" EXACT []
synonym: "small intestinal epithelium" EXACT []
synonym: "small intestine epithelial tissue" EXACT []
synonym: "small intestine epithelium" EXACT []
is_a: UBERON:0001277 ! intestinal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001204 ! mucosa of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0001905
name: pineal body
def: "A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399)." []
synonym: "conarium" RELATED []
synonym: "corpus pineale" EXACT []
synonym: "epiphysis" RELATED []
synonym: "epiphysis cerebri" RELATED []
synonym: "frontal organ" RELATED []
synonym: "glandula pinealis" EXACT []
synonym: "Pi" BROAD []
synonym: "pineal" RELATED []
synonym: "pineal gland" EXACT []
synonym: "pineal gland (Galen)" RELATED []
synonym: "pineal organ" EXACT []
synonym: "stirnorgan" RELATED []
is_a: UBERON:0003296 ! gland of diencephalon
is_a: UBERON:0010134 ! secretory circumventricular organ
relationship: part_of UBERON:0015238 ! pineal complex

[Term]
id: UBERON:0001911
name: mammary gland
def: "A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males." []
synonym: "Brustdruese" RELATED []
synonym: "dug" RELATED []
synonym: "glandula mammaria" EXACT []
synonym: "glandula mammaria" RELATED []
synonym: "lactiferous gland" EXACT []
synonym: "lobe of breast" NARROW []
synonym: "lobe of mammary gland" RELATED []
synonym: "mamma" RELATED []
synonym: "mammae" RELATED []
synonym: "milk patch" NARROW []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0019319 ! exocrine gland of integumental system
relationship: develops_from UBERON:0005333 ! mammary bud
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0001912
name: lobule of mammary gland
def: "Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA]" []
synonym: "acinus of mammary gland" EXACT []
synonym: "lactiferous acinus" EXACT []
synonym: "lactiferous gland lobule" EXACT []
synonym: "lactiferous lobule" EXACT []
synonym: "lobule of lactiferous gland" EXACT []
synonym: "lobule of mammary gland" EXACT []
synonym: "mammary acinus" EXACT []
synonym: "mammary gland lobule" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0009911 ! lobule
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0001915
name: endothelium of capillary
def: "An endothelium that is part of a capillary [Automatically generated definition]." []
synonym: "blood capillary endothelium" EXACT []
synonym: "capillary endothelium" EXACT []
synonym: "capillary vessel endothelium" EXACT []
synonym: "endothelium of blood capillary" EXACT []
synonym: "endothelium of capillary vessel" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001982 ! capillary
relationship: part_of UBERON:0001982 ! capillary

[Term]
id: UBERON:0001916
name: endothelium of arteriole
def: "An endothelium that is part of an arteriole [Automatically generated definition]." []
synonym: "arteriole endothelium" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004700 ! arterial system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001980 ! arteriole
relationship: part_of UBERON:0001980 ! arteriole

[Term]
id: UBERON:0001917
name: endothelium of artery
def: "An endothelium that is part of an artery [Automatically generated definition]." []
synonym: "arterial endothelium" EXACT []
synonym: "artery endothelium" EXACT []
is_a: UBERON:0003915 ! endothelial tube
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004700 ! arterial system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0001918
name: endothelium of venule
def: "An endothelium that is part of a venule [Automatically generated definition]." []
synonym: "venule endothelium" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004701 ! venous system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001979 ! venule
relationship: part_of UBERON:0001979 ! venule

[Term]
id: UBERON:0001919
name: endothelium of vein
def: "An endothelium that is part of a vein [Automatically generated definition]." []
synonym: "vein endothelium" EXACT []
synonym: "veinous endothelium" RELATED []
synonym: "venous endothelium" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004701 ! venous system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein

[Term]
id: UBERON:0001930
name: paraventricular nucleus of hypothalamus
def: "Nucleus in the anterior part of the hypothalamus. (MSH) * one of the magnocellular hypothalamic nuclei, an elongated plate of large, deeply staining cells located close to the third ventricle in the anterior hypothalamic area; major source of oxytocin and to a lesser extent, of antidiuretic hormone, neurohormones, which are carried to the neurohypophysis along the paraventriculohypophysial tract. (CSP)" []
synonym: "filiform nucleus" EXACT []
synonym: "nuclei paraventriculares" RELATED []
synonym: "nuclei paraventricularis hypothalami" RELATED []
synonym: "nucleus filiformis" RELATED []
synonym: "nucleus hypothalami filiformis" RELATED []
synonym: "nucleus hypothalami paraventricularis" RELATED []
synonym: "nucleus paraventricularis hypothalami" RELATED []
synonym: "Pa" BROAD []
synonym: "paraventricular hypothalamic nucleus" EXACT []
synonym: "paraventricular nucleus" EXACT []
synonym: "paraventricular nucleus hypothalamus (Malone)" RELATED []
synonym: "paraventricular nucleus of the hypothalamus" RELATED []
synonym: "parvocellular hypothalamic nucleus" RELATED []
synonym: "subcommissural nucleus (Ziehen)" RELATED []
is_a: UBERON:0006568 ! hypothalamic nucleus
relationship: part_of UBERON:0002271 ! periventricular zone of hypothalamus

[Term]
id: UBERON:0001943
name: midbrain tegmentum
def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." []
synonym: "mesencephalic tegmentum" RELATED []
synonym: "MTg" BROAD []
synonym: "tegmentum" BROAD []
synonym: "tegmentum mesencephali" EXACT []
synonym: "tegmentum mesencephalicum" RELATED []
synonym: "tegmentum of midbrain" EXACT []
is_a: UBERON:0002616 ! regional part of brain
relationship: develops_from UBERON:0010285 ! midbrain basal plate
relationship: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0002298 ! brainstem

[Term]
id: UBERON:0001948
name: regional part of spinal cord
def: "A multi-tissue structure that is part of a spinal cord." []
synonym: "spinal cord part" RELATED []
is_a: UBERON:0000073 ! regional part of nervous system
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0001949
name: gingival epithelium
def: "A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO]." []
synonym: "epithelial tissue of gingiva" EXACT []
synonym: "epithelium of gingiva" EXACT []
synonym: "gingiva epithelial tissue" EXACT []
synonym: "gingiva epithelium" EXACT []
is_a: UBERON:0002424 ! oral epithelium
is_a: UBERON:0006915 ! stratified squamous epithelium
is_a: UBERON:0035037 ! jaw epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001828 ! gingiva
relationship: part_of UBERON:0001828 ! gingiva

[Term]
id: UBERON:0001950
name: neocortex
def: "The term neocortex refers to those areas of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN)" []
synonym: "cerebral neocortex" EXACT []
synonym: "homogenetic cortex" EXACT []
synonym: "homotypical cortex" EXACT []
synonym: "iso-cortex" RELATED []
synonym: "isocortex" NARROW []
synonym: "isocortex (sensu lato)" EXACT []
synonym: "neocortex (isocortex)" EXACT []
synonym: "neopallial cortex" EXACT []
synonym: "neopallium" EXACT []
synonym: "nonolfactory cortex" RELATED []
synonym: "nucleus hypoglossalis" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: UBERON:0001951
name: epithelium of nasopharynx
def: "An epithelium that is part of a nasopharynx [Automatically generated definition]." []
synonym: "epithelial tissue of nasal part of pharynx" EXACT []
synonym: "epithelial tissue of nasopharynx" EXACT []
synonym: "epithelial tissue of rhinopharynx" EXACT []
synonym: "epithelium of nasal part of pharynx" EXACT []
synonym: "epithelium of rhinopharynx" EXACT []
synonym: "nasal part of pharynx epithelial tissue" EXACT []
synonym: "nasal part of pharynx epithelium" EXACT []
synonym: "nasopharyngeal epithelium" RELATED []
synonym: "nasopharynx epithelial tissue" EXACT []
synonym: "nasopharynx epithelium" EXACT []
synonym: "rhinopharynx epithelial tissue" EXACT []
synonym: "rhinopharynx epithelium" EXACT []
is_a: UBERON:0003351 ! pharyngeal epithelium
is_a: UBERON:0004814 ! upper respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0003929 ! digestive tract epithelium

[Term]
id: UBERON:0001954
name: Ammon's horn
def: "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." []
synonym: "ammon gyrus" EXACT []
synonym: "ammon horn" EXACT []
synonym: "Ammon horn fields" RELATED []
synonym: "Ammon's horn" EXACT []
synonym: "Ammons horn" RELATED []
synonym: "cornu ammonis" RELATED []
synonym: "hippocampus" RELATED []
synonym: "hippocampus major" EXACT []
synonym: "hippocampus proper" EXACT []
synonym: "hippocampus proprius" EXACT []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000349 ! limbic system
relationship: part_of UBERON:0002421 ! hippocampal formation
relationship: part_of UBERON:0002600 ! limbic lobe

[Term]
id: UBERON:0001955
name: epithelium of respiratory bronchiole
def: "An epithelium that is part of a respiratory bronchiole [Automatically generated definition]." []
synonym: "bronchiolus respiratorius epithelial tissue" EXACT []
synonym: "bronchiolus respiratorius epithelium" EXACT []
synonym: "epithelial tissue of bronchiolus respiratorius" EXACT []
synonym: "epithelial tissue of respiratory bronchiole" EXACT []
synonym: "epithelium of bronchiolus respiratorius" EXACT []
synonym: "respiratory bronchiole epithelial tissue" EXACT []
synonym: "respiratory bronchiole epithelium" EXACT []
is_a: UBERON:0002051 ! epithelium of bronchiole
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002188 ! respiratory bronchiole
relationship: part_of UBERON:0002188 ! respiratory bronchiole

[Term]
id: UBERON:0001956
name: cartilage of bronchus
def: "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." []
synonym: "bronchi cartilage" EXACT []
synonym: "bronchial cartilage" EXACT []
synonym: "bronchial cartilage ring" EXACT []
synonym: "bronchial trunk cartilage" EXACT []
synonym: "bronchus cartilage" EXACT []
synonym: "cartilage of bronchi" EXACT []
synonym: "cartilage of bronchial trunk" EXACT []
synonym: "cartilagines bronchiales" EXACT []
is_a: UBERON:0001994 ! hyaline cartilage tissue
is_a: UBERON:0003592 ! bronchus connective tissue
is_a: UBERON:0003603 ! lower respiratory tract cartilage
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0001957
name: submucosa of bronchus
def: "A submucosa that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi submucosa" EXACT []
synonym: "bronchial submucosa" EXACT []
synonym: "bronchial trunk submucosa" EXACT []
synonym: "bronchus submucosa" EXACT []
synonym: "submucosa of bronchi" EXACT []
synonym: "submucosa of bronchial trunk" EXACT []
synonym: "submucous layer of bronchi" RELATED []
synonym: "tela submucosa bronchi" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004777 ! respiratory system submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0001958
name: terminal bronchiole epithelium
def: "An epithelium that lines a terminal bronchiole." []
synonym: "bronchiolus terminalis epithelial tissue" EXACT []
synonym: "bronchiolus terminalis epithelium" EXACT []
synonym: "epithelial tissue of bronchiolus terminalis" EXACT []
synonym: "epithelial tissue of terminal bronchiole" EXACT []
synonym: "epithelium of bronchiolus terminalis" EXACT []
synonym: "epithelium of terminal bronchiole" EXACT []
synonym: "terminal bronchiole epithelial tissue" EXACT []
synonym: "terminal bronchiole epithelium" EXACT []
is_a: UBERON:0002051 ! epithelium of bronchiole
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002187 ! terminal bronchiole
relationship: part_of UBERON:0002187 ! terminal bronchiole

[Term]
id: UBERON:0001959
name: white pulp of spleen
def: "the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" []
synonym: "noduli lymphoidei splenici" RELATED []
synonym: "pulpa alba" EXACT []
synonym: "spleen white pulp" EXACT []
synonym: "splenic white pulp" EXACT []
synonym: "white pulp" EXACT []
is_a: UBERON:1000023 ! spleen pulp

[Term]
id: UBERON:0001961
name: mucosa-associated lymphoid tissue
def: "diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." []
synonym: "epithelio-lymphoid tissue" EXACT []
synonym: "MALT" EXACT []
synonym: "mucosa associated lymphatic tissue" EXACT []
synonym: "mucosa associated lymphoid tissue" EXACT []
synonym: "mucosa-associated lymphoid tissue" EXACT []
synonym: "mucosal-associated lymphatic tissue" EXACT []
synonym: "mucosal-associated lymphoid tissue" EXACT []
is_a: UBERON:0012069 ! epithelium-associated lymphoid tissue

[Term]
id: UBERON:0001962
name: gut-associated lymphoid tissue
def: "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." []
synonym: "GALT" RELATED []
synonym: "gut associated lymphoid tissue" EXACT []
is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue
intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0001963
name: bronchial-associated lymphoid tissue
def: "A diffuse collection of lymphpoid cells that participate in airway immune responses" []
synonym: "BALT" RELATED []
synonym: "bronchus associated lymphoid tissue" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0001969
name: blood plasma
def: "The liquid component of blood, in which erythrocytes are suspended." []
synonym: "blood plasm" EXACT []
synonym: "plasma" BROAD []
synonym: "portion of blood plasma" EXACT []
synonym: "portion of plasma" BROAD []
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0000178 ! blood

[Term]
id: UBERON:0001972
name: submucosa of esophagus
def: "A submucosa that is part of a esophagus [Automatically generated definition]." []
synonym: "esophageal submucosa" EXACT []
synonym: "esophagus submucosa" EXACT []
synonym: "gullet submucosa" EXACT []
synonym: "oesophagus submucosa" EXACT []
synonym: "submucosa of esophagus" EXACT []
synonym: "submucosa of gullet" EXACT []
synonym: "submucosa of oesophagus" EXACT []
synonym: "submucous layer of esophagus" RELATED []
synonym: "tela submucosa (oesophagus)" EXACT []
synonym: "tela submucosa esophagi" EXACT []
synonym: "tela submucosa oesophageae" EXACT []
synonym: "tela submucosa oesophagi" RELATED []
synonym: "tela submucosa of esophagus" EXACT []
is_a: UBERON:0018257 ! submucosa of digestive tract
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001096 ! wall of esophagus

[Term]
id: UBERON:0001974
name: lamina propria of esophagus
def: "A lamina propria that is part of a esophagus [Automatically generated definition]." []
synonym: "esophageal lamina propria" RELATED []
synonym: "esophagus lamina propria" EXACT []
synonym: "esophagus lamina propria mucosa" EXACT []
synonym: "esophagus lamina propria mucosae" EXACT []
synonym: "gullet lamina propria" EXACT []
synonym: "gullet lamina propria mucosa" EXACT []
synonym: "gullet lamina propria mucosae" EXACT []
synonym: "lamina propria mucosa of esophagus" EXACT []
synonym: "lamina propria mucosa of gullet" EXACT []
synonym: "lamina propria mucosa of oesophagus" EXACT []
synonym: "lamina propria mucosae of esophagus" EXACT []
synonym: "lamina propria mucosae of gullet" EXACT []
synonym: "lamina propria mucosae of oesophagus" EXACT []
synonym: "lamina propria of gullet" EXACT []
synonym: "lamina propria of oesophagus" EXACT []
synonym: "oesophagus lamina propria" RELATED []
synonym: "oesophagus lamina propria mucosa" EXACT []
synonym: "oesophagus lamina propria mucosae" EXACT []
is_a: UBERON:0000030 ! lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0002469 ! esophagus mucosa

[Term]
id: UBERON:0001975
name: serosa of esophagus
def: "A serous membrane that is part of a esophagus [Automatically generated definition]." []
synonym: "esophagus serosa" EXACT []
synonym: "esophagus serous membrane" EXACT []
synonym: "gullet serosa" EXACT []
synonym: "gullet serous membrane" EXACT []
synonym: "oesophagus serosa" RELATED []
synonym: "oesophagus serous membrane" EXACT []
synonym: "serosa of abdominal part of esophagus" EXACT []
synonym: "serosa of gullet" EXACT []
synonym: "serosa of oesophagus" EXACT []
synonym: "serous coat of oesophagus" EXACT []
synonym: "serous membrane of esophagus" EXACT []
synonym: "serous membrane of gullet" EXACT []
synonym: "serous membrane of oesophagus" EXACT []
synonym: "tunica serosa oesophageae" EXACT []
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001096 ! wall of esophagus

[Term]
id: UBERON:0001976
name: epithelium of esophagus
def: "the epithelial layer that lines the luminal space of the esophagus" []
synonym: "epithelial tissue of esophagus" EXACT []
synonym: "epithelial tissue of gullet" EXACT []
synonym: "epithelial tissue of oesophagus" EXACT []
synonym: "epithelium of gullet" EXACT []
synonym: "epithelium of oesophagus" EXACT []
synonym: "esophageal epithelium" EXACT []
synonym: "esophagus epithelial tissue" EXACT []
synonym: "esophagus epithelium" EXACT []
synonym: "gullet epithelial tissue" EXACT []
synonym: "gullet epithelium" EXACT []
synonym: "oesophagus epithelial tissue" EXACT []
synonym: "oesophagus epithelium" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0002469 ! esophagus mucosa

[Term]
id: UBERON:0001979
name: venule
def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" []
synonym: "venula" RELATED []
is_a: UBERON:0003920 ! venous blood vessel
relationship: part_of UBERON:0001009 ! circulatory system

[Term]
id: UBERON:0001980
name: arteriole
def: "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." []
synonym: "arteriola" RELATED []
is_a: UBERON:0003509 ! arterial blood vessel

[Term]
id: UBERON:0001981
name: blood vessel
def: "A vessel through which blood circulates in the body." []
synonym: "region of vascular tree organ" EXACT []
synonym: "vas sanguineum" RELATED []
synonym: "vascular element" BROAD []
synonym: "vascular tree organ region" EXACT []
is_a: UBERON:0000055 ! vessel
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: develops_from UBERON:0006965 ! vascular cord
relationship: has_part UBERON:0007500 ! epithelial tube open at both ends
relationship: part_of UBERON:0004537 ! blood vasculature

[Term]
id: UBERON:0001982
name: capillary
def: "Any of the smallest blood vessels connecting arterioles with venules." []
synonym: "blood capillary" EXACT []
synonym: "capillary vessel" EXACT []
is_a: UBERON:0001981 ! blood vessel
is_a: UBERON:0010523 ! microcirculatory vessel

[Term]
id: UBERON:0001983
name: crypt of Lieberkuhn
def: "the tubular intestinal glands found in the mucosal membranes" []
synonym: "crypt of lieberkuhn" EXACT []
synonym: "crypt of Lieberkühn" EXACT []
synonym: "crypts of Lieberkühn" EXACT []
synonym: "follicles of lieberkuhn" EXACT []
synonym: "intestinal crypt" EXACT []
synonym: "intestinal crypts" EXACT []
synonym: "intestinal gland" BROAD []
synonym: "intestinal gland of Lieberkuhn" RELATED []
synonym: "Lieberkuhn crypt" EXACT []
synonym: "lieberkuhn crypt" EXACT []
synonym: "Lieberkuhn gland" EXACT []
synonym: "Lieberkuhn's gland" EXACT []
synonym: "Lieberkuhn's glands" EXACT []
is_a: UBERON:0000333 ! intestinal gland
relationship: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: UBERON:0001984
name: crypt of Lieberkuhn of large intestine
def: "A crypt of lieberkuhn that is part of a large intestine [Automatically generated definition]." []
synonym: "intestinal gland of large intestine" EXACT []
synonym: "large intestinal crypt of lieberkuhn" EXACT []
synonym: "large intestine crypt of lieberkuhn" EXACT []
synonym: "large intestine intestinal gland" EXACT []
synonym: "large intestine lieberkuhn crypt" EXACT []
synonym: "lieberkuhn crypt of large intestine" EXACT []
is_a: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001207 ! mucosa of large intestine

[Term]
id: UBERON:0001985
name: corneal endothelium
def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." []
synonym: "cornea endothelium" EXACT []
synonym: "endothelium of cornea" EXACT []
synonym: "epithelium posterius corneae" RELATED []
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: UBERON:0001986
name: endothelium
def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]" []
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0001987
name: placenta
def: "organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." []
synonym: "allantoic placenta" EXACT []
synonym: "eutherian placenta" EXACT []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
relationship: develops_from UBERON:0000995 ! uterus
relationship: develops_from UBERON:0003124 ! chorion
relationship: develops_from UBERON:0004340 ! allantois
relationship: part_of UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0001992
name: papillary layer of dermis
def: "The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified]." []
synonym: "corpus papillary" EXACT []
synonym: "dermal papillary layer" RELATED []
synonym: "dermis papillary layer" EXACT []
synonym: "papillary dermis" EXACT []
synonym: "papillary layer" EXACT []
synonym: "papillary layer of dermis" EXACT []
synonym: "stratum papillare" EXACT []
synonym: "stratum papillare" RELATED []
synonym: "stratum papillare (Dermis)" EXACT []
synonym: "stratum papillare corii" EXACT []
synonym: "stratum papillare dermis" EXACT []
synonym: "superficial dermis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0013754 ! integumentary system layer
relationship: part_of UBERON:0002067 ! dermis

[Term]
id: UBERON:0001993
name: reticular layer of dermis
def: "The thicker, deeper layer of the dermis, comprised of criss-crossing collagen fibers that form a strong elastic network and also containing blood and lymph vessels, nerves and nerve endings, and hair follicles" []
synonym: "dermal reticular layer" RELATED []
synonym: "dermis reticular layer" EXACT []
synonym: "dermis stratum reticulare" EXACT []
synonym: "reticular dermis" EXACT []
synonym: "stratum reticulare" EXACT []
synonym: "stratum reticulare" RELATED []
synonym: "stratum reticulare dermis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0013754 ! integumentary system layer
relationship: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0008877 ! epidermal-dermal junction

[Term]
id: UBERON:0001994
name: hyaline cartilage tissue
def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." []
synonym: "chondroid cartilage" RELATED []
synonym: "hyaline cartilage" EXACT []
is_a: UBERON:0002418 ! cartilage tissue

[Term]
id: UBERON:0001995
name: fibrocartilage
def: "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." []
synonym: "fibrocartilage tissue" EXACT []
synonym: "stratified cartilage tissue" EXACT []
is_a: UBERON:0002418 ! cartilage tissue

[Term]
id: UBERON:0001997
name: olfactory epithelium
def: "A sensory epithelium inside the nasal cavity that is responsible for detecting odors[WP]." []
synonym: "main olfactory epithelium" EXACT []
synonym: "MOE" RELATED []
synonym: "nasal cavity olfactory epithelium" EXACT []
synonym: "nasal epithelium" RELATED []
synonym: "nasal sensory epithelium" RELATED []
synonym: "olfactory membrane" EXACT []
synonym: "olfactory sensory epithelium" EXACT []
synonym: "pseudostratified main olfactory epithelium" RELATED []
synonym: "sensory olfactory epithelium" EXACT []
is_a: UBERON:0005384 ! nasal cavity epithelium
is_a: UBERON:0006934 ! sensory epithelium
intersection_of: UBERON:0006934 ! sensory epithelium
intersection_of: part_of UBERON:0005386 ! olfactory segment of nasal mucosa
relationship: part_of UBERON:0000012 ! somatic nervous system
relationship: part_of UBERON:0005386 ! olfactory segment of nasal mucosa

[Term]
id: UBERON:0002005
name: enteric nervous system
def: "The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO]." []
synonym: "enteric PNS" EXACT []
synonym: "PNS - enteric" EXACT []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: develops_from UBERON:0005428 ! vagal neural crest
relationship: part_of UBERON:0002410 ! autonomic nervous system

[Term]
id: UBERON:0002006
name: cortex of lymph node
def: "Peripheral portion of the lymph node, underneath the capsule[WP]." []
synonym: "cortex nodi lymphoidei" RELATED []
synonym: "lymph node cortex" EXACT []
is_a: UBERON:0001851 ! cortex
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: UBERON:0002007
name: medulla of lymph node
def: "The mdeullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." []
synonym: "lymph node medulla" EXACT []
synonym: "medulla nodi lymphoidei" RELATED []
is_a: UBERON:0000958 ! medulla of organ
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: has_part UBERON:0009744 ! lymph node medullary sinus
relationship: has_part UBERON:0009745 ! lymph node medullary cord
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: UBERON:0002012
name: pulmonary artery
def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." []
synonym: "arteria pulmonalis" RELATED []
synonym: "pulmonary arterial subtree" RELATED []
synonym: "pulmonary arterial tree" EXACT []
synonym: "pulmonary arterial tree organ part" EXACT []
synonym: "truncus pulmonalis" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001637 ! artery
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0013768 ! great vessel of heart
disjoint_from: UBERON:0004573 ! systemic artery
relationship: develops_from UBERON:0002061 ! truncus arteriosus
relationship: develops_from UBERON:0003123 ! pharyngeal arch artery 6
relationship: develops_from UBERON:0005339 ! outflow tract pulmonary component
relationship: part_of UBERON:0008886 ! pulmonary vascular system

[Term]
id: UBERON:0002016
name: pulmonary vein
def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." []
synonym: "pulmonary venous tree organ part" EXACT []
synonym: "venae pulmonales" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001638 ! vein
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0013768 ! great vessel of heart
relationship: develops_from UBERON:0002061 ! truncus arteriosus
relationship: part_of UBERON:0008886 ! pulmonary vascular system

[Term]
id: UBERON:0002017
name: portal vein
def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." []
synonym: "portal venous tree organ part" EXACT []
is_a: UBERON:0001638 ! vein
relationship: part_of UBERON:0005806 ! portal system

[Term]
id: UBERON:0002018
name: synovial membrane of synovial joint
def: "Soft tissue that lines the non-cartilaginous surfaces within joints with cavities (synovial joints)." []
synonym: "membrana synovialis (Capsula articularis)" EXACT []
synonym: "membrana synovialis capsulae articularis" EXACT []
synonym: "stratum synoviale" EXACT []
synonym: "stratum synoviale (Capsula articularis)" EXACT []
synonym: "synovial layer" BROAD []
synonym: "synovial layer of articular capsule of synovial joint" RELATED []
synonym: "synovial membrane" BROAD []
synonym: "synovial membrane of articular capsule of synovial joint" RELATED []
synonym: "synovium" BROAD []
synonym: "synovium of articular capsule of synovial joint" RELATED []
is_a: UBERON:0006915 ! stratified squamous epithelium
is_a: UBERON:0007616 ! layer of synovial tissue
is_a: UBERON:0012275 ! meso-epithelium
relationship: part_of UBERON:0002217 ! synovial joint

[Term]
id: UBERON:0002020
name: gray matter
def: "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." []
synonym: "gray mater" RELATED []
synonym: "gray matter" EXACT []
synonym: "gray matter of neuraxis" EXACT []
synonym: "grey matter" EXACT []
synonym: "grey matter of neuraxis" EXACT []
synonym: "grey substance" EXACT []
synonym: "grisea" RELATED []
synonym: "neuronal grey matter" EXACT []
synonym: "substantia grisea" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0002025
name: stratum basale of epidermis
def: "the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" []
synonym: "basal cell layer of epidermis" EXACT []
synonym: "basal cell layer of skin" RELATED []
synonym: "basal epidermal layer" EXACT []
synonym: "basal layer of epidermis" RELATED []
synonym: "epidermal basal stratum" EXACT []
synonym: "epidermis basal layer" RELATED []
synonym: "epidermis sensorial layer" RELATED []
synonym: "epidermis stratum basale" EXACT []
synonym: "epidermis stratum germinativum" RELATED []
synonym: "Malpighian layer" RELATED []
synonym: "rete Malphighii" EXACT []
synonym: "stratum basale" BROAD []
synonym: "stratum basalis of epidermis" EXACT []
synonym: "stratum germinativum" EXACT []
synonym: "stratum germinosum" BROAD []
synonym: "stratum germinosum of epidermis" EXACT []
synonym: "stratum Malphighi" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0013754 ! integumentary system layer
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0002026
name: stratum spinosum of epidermis
def: "the layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance" []
synonym: "epidermis prickle cell layer" RELATED []
synonym: "epidermis stratum spinosum" EXACT []
synonym: "prickle cell layer" RELATED []
synonym: "prickle cell layer of epidermis" EXACT []
synonym: "squamous cell layer of epidermis" EXACT []
synonym: "stratum malphighii" EXACT []
synonym: "stratum spinosum" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0013754 ! integumentary system layer
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0002027
name: stratum corneum of epidermis
def: "the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" []
synonym: "cornified layer" EXACT []
synonym: "epidermis stratum corneum" EXACT []
synonym: "horny layer" BROAD []
synonym: "horny layer of epidermis" EXACT []
synonym: "keratinized squame layer" BROAD []
synonym: "keratinized squame layer of epidermis" EXACT []
synonym: "stratum corneum" BROAD []
synonym: "stratum corneum epidermidis" RELATED []
is_a: UBERON:0003055 ! periderm
is_a: UBERON:0013754 ! integumentary system layer

[Term]
id: UBERON:0002028
name: hindbrain
def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." []
synonym: "rhombencephalon" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0002029
name: epithelium of gall bladder
def: "The simple columnar epithelial lining of the gall bladder." []
synonym: "biliary epithelium" RELATED []
synonym: "epithelial tissue of gall bladder" EXACT []
synonym: "epithelial tissue of gallbladder" EXACT []
synonym: "epithelium of gallbladder" EXACT []
synonym: "gall bladder epithelial tissue" EXACT []
synonym: "gall bladder epithelium" EXACT []
synonym: "gallbladder epithelial tissue" EXACT []
synonym: "gallbladder epithelium" EXACT []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: UBERON:0002031
name: epithelium of bronchus
def: "An epithelium that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi epithelial tissue" EXACT []
synonym: "bronchi epithelium" EXACT []
synonym: "bronchial epithelium" EXACT []
synonym: "bronchial trunk epithelial tissue" EXACT []
synonym: "bronchial trunk epithelium" EXACT []
synonym: "bronchus epithelial tissue" EXACT []
synonym: "bronchus epithelium" EXACT []
synonym: "epithelial tissue of bronchi" EXACT []
synonym: "epithelial tissue of bronchial trunk" EXACT []
synonym: "epithelial tissue of bronchus" EXACT []
synonym: "epithelium of bronchi" EXACT []
synonym: "epithelium of bronchial trunk" EXACT []
is_a: UBERON:0004815 ! lower respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0002033
name: arrector muscle of hair
def: "A tiny smooth muscle that connects the hair follicle with the dermis." []
synonym: "arectores pilorum" RELATED []
synonym: "arrector pili" EXACT []
synonym: "arrector pili muscle" EXACT []
synonym: "arrector pili smooth muscle" EXACT []
synonym: "arrector pilli" EXACT []
synonym: "arrector pilli muscle" EXACT []
synonym: "arrector pilorum" EXACT []
synonym: "arrector pilorum muscle of hair" EXACT []
synonym: "erector pili" RELATED []
synonym: "erectores pilorum" RELATED []
synonym: "pilomotor muscle" RELATED []
is_a: UBERON:0001135 ! smooth muscle tissue
relationship: part_of UBERON:0011932 ! pilosebaceous unit

[Term]
id: UBERON:0002036
name: striated muscle tissue
def: "Muscle tissue that contains fibers that are divided by transverse bands into striations." []
synonym: "striated muscle" EXACT []
is_a: UBERON:0002385 ! muscle tissue

[Term]
id: UBERON:0002037
name: cerebellum
def: "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." []
synonym: "corpus cerebelli" RELATED []
synonym: "epencephalon-1" EXACT []
synonym: "infratentorial region" BROAD []
synonym: "parencephalon" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0006215 ! rhombic lip
relationship: part_of UBERON:0001895 ! metencephalon
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0002038
name: substantia nigra
def: "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." []
synonym: "nucleus of basis pedunculi" EXACT []
synonym: "nucleus pigmentosus subthalamo-peduncularis" RELATED []
synonym: "SN" BROAD []
synonym: "Soemmering's substance" EXACT []
synonym: "substancia nigra" RELATED []
synonym: "substantia nigra (Soemmerringi)" RELATED []
is_a: UBERON:0009661 ! midbrain nucleus
relationship: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0002420 ! basal ganglion

[Term]
id: UBERON:0002042
name: lymphatic vessel endothelium
def: "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." []
synonym: "endothelium of lymph vessel" EXACT []
synonym: "endothelium of lymphatic vessel" EXACT []
synonym: "lymph vessel endothelium" EXACT []
synonym: "lymphatic endothelium" EXACT []
synonym: "lymphatic vessel endothelium" EXACT []
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: part_of UBERON:0001473 ! lymphatic vessel

[Term]
id: UBERON:0002046
name: thyroid gland
def: "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." []
synonym: "glandula thyroidea" RELATED []
synonym: "thyroid" EXACT []
is_a: UBERON:0002368 ! endocrine gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0002048
name: lung
def: "Respiration organ that develops as an oupocketing of the esophagus." []
synonym: "pulmo" EXACT []
is_a: UBERON:0000171 ! respiration organ
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005178 ! thoracic cavity element
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0000118 ! lung bud
relationship: part_of UBERON:0000170 ! pair of lungs

[Term]
id: UBERON:0002049
name: vasculature
def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." []
synonym: "vascular network" EXACT []
is_a: UBERON:0000477 ! anatomical cluster
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system

[Term]
id: UBERON:0002050
name: embryonic structure
def: "Anatomical structure that is part of an embryo." []
synonym: "developing embryonic structure" EXACT []
synonym: "developing structure" RELATED []
synonym: "embryonale Struktur" RELATED []
synonym: "embryonic anatomical structure" EXACT []
synonym: "embryonic structures" RELATED []
is_a: UBERON:0000061 ! anatomical structure
is_a: UBERON:0005423 ! developing anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0002051
name: epithelium of bronchiole
def: "An epithelium that is part of a bronchiole [Automatically generated definition]." []
synonym: "bronchiolar epithelium" EXACT []
synonym: "bronchiole epithelial tissue" EXACT []
synonym: "bronchiole epithelium" EXACT []
synonym: "epithelial tissue of bronchiole" EXACT []
synonym: "epithelial tissue of lobular bronchiole" EXACT []
synonym: "epithelium of lobular bronchiole" EXACT []
synonym: "lobular bronchiole epithelial tissue" EXACT []
synonym: "lobular bronchiole epithelium" EXACT []
is_a: UBERON:0000115 ! lung epithelium
is_a: UBERON:0002031 ! epithelium of bronchus
is_a: UBERON:0003350 ! epithelium of mucosa
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0005039 ! mucosa of bronchiole

[Term]
id: UBERON:0002053
name: zona glomerulosa of adrenal gland
def: "the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced" []
synonym: "adrenal gland zona glomerulosa" EXACT []
synonym: "glomerulosa" RELATED []
synonym: "zona glomerulosa" EXACT []
synonym: "zona glomerulosa of suprarenal gland" EXACT []
is_a: UBERON:0009753 ! adrenal gland cortex zone
relationship: part_of UBERON:0001235 ! adrenal cortex

[Term]
id: UBERON:0002061
name: truncus arteriosus
def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001637 ! artery
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003498 ! heart blood vessel
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005432 ! aortic sac
relationship: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0005498 ! primitive heart tube

[Term]
id: UBERON:0002062
name: endocardial cushion
def: "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." []
synonym: "atrioventricular canal cushion" RELATED []
synonym: "atrioventricular cushion" EXACT []
synonym: "AV cushion" EXACT []
synonym: "cardiac cushion" EXACT []
synonym: "endocardial cushion tissue" EXACT []
synonym: "endocardial cushions" RELATED []
is_a: UBERON:0005256 ! trunk mesenchyme
is_a: UBERON:0009751 ! cardiac mesenchyme
is_a: UBERON:0014387 ! mesenchyme derived from neural crest
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0002165 ! endocardium

[Term]
id: UBERON:0002066
name: umbilical vein
def: "The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted]." []
synonym: "vena umbilicalis" RELATED []
is_a: UBERON:0001638 ! vein
is_a: UBERON:0010260 ! umbilical blood vessel

[Term]
id: UBERON:0002067
name: dermis
def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." []
synonym: "corium" RELATED []
synonym: "cutis" RELATED []
synonym: "vertebrate dermis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0013754 ! integumentary system layer
relationship: has_part UBERON:0011860 ! collection of collagen fibrils
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: UBERON:0002069
name: stratum granulosum of epidermis
def: "the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" []
synonym: "epidermis granular layer" RELATED []
synonym: "epidermis stratum granulosum" EXACT []
synonym: "granular layer of epidermis" EXACT []
synonym: "stratum granulosum" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0013754 ! integumentary system layer
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0002072
name: hypodermis
def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." []
synonym: "hypoderm" EXACT []
synonym: "sub-tegumental tissue" RELATED []
synonym: "subcutaneous tissue" RELATED []
synonym: "subcutis" RELATED []
synonym: "subtegumental tissue" RELATED []
synonym: "superficial fascia" RELATED []
synonym: "tela subcutanea" RELATED []
synonym: "vertebrate hypodermis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013754 ! integumentary system layer
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:0002073
name: hair follicle
def: "A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." []
synonym: "folliculus pili" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005086 ! hair follicle placode
relationship: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0011932 ! pilosebaceous unit

[Term]
id: UBERON:0002074
name: hair shaft
def: "The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla." []
synonym: "scapus pili" RELATED []
synonym: "shaft of hair" EXACT []
is_a: UBERON:0000021 ! cutaneous appendage
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001037 ! strand of hair

[Term]
id: UBERON:0002075
name: viscus
def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." []
synonym: "Organsystem@ge" RELATED []
synonym: "splanchnic tissue" RELATED []
synonym: "viscera" RELATED []
synonym: "visceral organ" EXACT []
synonym: "visceral organ system" EXACT []
synonym: "visceral tissue" RELATED []
is_a: UBERON:0005177 ! trunk region element
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0002077
name: cortex of hair
def: "A cortex that is part of a hair [Automatically generated definition]." []
synonym: "coat hair cortex" EXACT []
synonym: "coat/hair cortex" EXACT []
synonym: "cortex of coat hair" EXACT []
synonym: "cortex of coat/hair" EXACT []
synonym: "hair cortex" EXACT []
is_a: UBERON:0001851 ! cortex
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0001037 ! strand of hair
relationship: part_of UBERON:0001037 ! strand of hair
relationship: part_of UBERON:0002074 ! hair shaft

[Term]
id: UBERON:0002080
name: heart right ventricle
def: "A cardiac ventricle that is in the right side of the heart." []
synonym: "cardiac right ventricle" EXACT []
synonym: "right cardiac ventricle" RELATED []
synonym: "right ventricle" EXACT []
synonym: "right ventricle of heart" EXACT []
synonym: "ventriculus dexter" RELATED []
is_a: UBERON:0002082 ! cardiac ventricle
is_a: UBERON:0035554 ! right cardiac chamber
relationship: develops_from UBERON:0009889 ! secondary heart field

[Term]
id: UBERON:0002081
name: cardiac atrium
def: "Cardiac chamber in which blood enters the heart." []
synonym: "atria" EXACT []
synonym: "atrial tissue" RELATED []
synonym: "atrium" EXACT []
synonym: "atrium of heart" EXACT []
synonym: "Cardiac atria" EXACT []
synonym: "cardiac atria" EXACT []
synonym: "heart atrium" EXACT []
is_a: UBERON:0004151 ! cardiac chamber

[Term]
id: UBERON:0002082
name: cardiac ventricle
def: "Cardiac chamber through which blood leaves the heart." []
synonym: "heart ventricle" EXACT []
synonym: "lower chamber of heart" EXACT []
synonym: "ventricle" BROAD []
synonym: "ventricle of heart" EXACT []
is_a: UBERON:0004151 ! cardiac chamber

[Term]
id: UBERON:0002084
name: heart left ventricle
def: "A cardiac ventricle that is in the left side of the heart." []
synonym: "cardiac left ventricle" EXACT []
synonym: "left cardiac ventricle" EXACT []
synonym: "left ventricle" EXACT []
synonym: "left ventricle of heart" EXACT []
synonym: "ventriculus sinister cordis" RELATED []
is_a: UBERON:0002082 ! cardiac ventricle
is_a: UBERON:0035553 ! left cardiac chamber
relationship: develops_from UBERON:0004140 ! primary heart field

[Term]
id: UBERON:0002085
name: interatrial septum
def: "A cardiac septum that divides the left and right atria of the heart." []
synonym: "atrial septum" EXACT []
synonym: "atrium septum" EXACT []
synonym: "interatrial septal wall" EXACT []
is_a: UBERON:0002099 ! cardiac septum

[Term]
id: UBERON:0002091
name: appendicular skeleton
def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." []
synonym: "appendicular skeleton" EXACT []
synonym: "entire appendicular skeleton" EXACT []
synonym: "paired fin skeleton" NARROW []
synonym: "skeleton appendiculare" RELATED []
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0011249 ! appendicular skeletal system

[Term]
id: UBERON:0002092
name: brain dura mater
def: "The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer." []
synonym: "cranial dura mater" EXACT []
synonym: "dura mater cranialis" EXACT []
synonym: "dura mater encephali" EXACT []
synonym: "dura mater of brain" EXACT []
is_a: UBERON:0002363 ! dura mater
is_a: UBERON:0003547 ! brain meninx
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0002093
name: spinal dura mater
def: "A dura mater that is part of a spinal cord [Automatically generated definition]." []
synonym: "dura mater of neuraxis of spinal cord" EXACT []
synonym: "dura mater of spinal cord" EXACT []
synonym: "spinal cord dura mater" EXACT []
synonym: "spinal cord dura mater of neuraxis" EXACT []
is_a: UBERON:0002363 ! dura mater
is_a: UBERON:0003292 ! meninx of spinal cord
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0002094
name: interventricular septum
def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]" []
synonym: "heart interventricular septum" EXACT []
synonym: "heart ventricular septum" EXACT []
synonym: "interventricular septum of heart" RELATED []
synonym: "interventriculare cordis" RELATED []
synonym: "intraventricular septum" RELATED []
synonym: "s. interventriculare cordis" RELATED []
synonym: "septum inferius" RELATED []
synonym: "septum membranaceum" RELATED []
synonym: "ventricle septum" RELATED []
synonym: "ventricular septum" RELATED []
is_a: UBERON:0002099 ! cardiac septum

[Term]
id: UBERON:0002095
name: mesentery
def: "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." []
synonym: "generic mesentery" EXACT []
synonym: "mesentery (generic)" EXACT []
is_a: UBERON:0000042 ! serous membrane

[Term]
id: UBERON:0002097
name: skin of body
def: "The organ covering the body that consists of the dermis and epidermis." []
synonym: "entire integument" RELATED []
synonym: "entire skin" EXACT []
synonym: "integument" RELATED []
synonym: "integumental organ" RELATED []
synonym: "pelt" RELATED []
synonym: "skin" RELATED []
synonym: "skin organ" EXACT []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:0002099
name: cardiac septum
def: "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." []
synonym: "cardiac septa" EXACT []
synonym: "heart septa" EXACT []
synonym: "heart septum" EXACT []
synonym: "septum of heart" EXACT []
synonym: "spiral septa" RELATED []
is_a: UBERON:0003037 ! septum
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003037 ! septum
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0002100
name: trunk
def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." []
synonym: "Rumpf" RELATED []
synonym: "thoracolumbar region" EXACT []
synonym: "torso" EXACT []
synonym: "trunk region" EXACT []
is_a: UBERON:0011676 ! subdivision of organism along main body axis
relationship: part_of UBERON:0013702 ! body proper

[Term]
id: UBERON:0002101
name: limb
def: "A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts." []
synonym: "extremities" RELATED []
synonym: "extremity" RELATED []
synonym: "flipper" NARROW []
synonym: "free limb" EXACT []
synonym: "limb sensu vertebrata" EXACT []
synonym: "pentadactyl limb" EXACT []
synonym: "tetrapod limb" EXACT []
is_a: UBERON:0004708 ! paired limb/fin
relationship: develops_from UBERON:0004347 ! limb bud

[Term]
id: UBERON:0002102
name: forelimb
def: "A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." []
synonym: "anteriormost limb" EXACT []
synonym: "fore limb" EXACT []
synonym: "foreleg" RELATED []
synonym: "forelimb" EXACT []
synonym: "free part of upper limb" EXACT []
synonym: "free upper limb" EXACT []
synonym: "membrum superius" EXACT []
synonym: "pectoral flipper" NARROW []
synonym: "pectoral limb" EXACT []
synonym: "superior member" EXACT []
synonym: "upper extremity" EXACT []
synonym: "upper limb" EXACT []
is_a: UBERON:0002101 ! limb
is_a: UBERON:0004710 ! pectoral appendage
intersection_of: UBERON:0002101 ! limb
intersection_of: part_of UBERON:0010708 ! pectoral complex
relationship: develops_from UBERON:0005417 ! forelimb bud
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0002103
name: hindlimb
def: "A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts." []
synonym: "free lower limb" EXACT []
synonym: "free part of lower limb" RELATED []
synonym: "hind limb" EXACT []
synonym: "hind-limb" EXACT []
synonym: "hindlimb" EXACT []
synonym: "inferior member" EXACT []
synonym: "lower extremity" RELATED []
synonym: "lower limb" EXACT []
synonym: "membrum inferius" EXACT []
synonym: "membrum inferius" RELATED []
synonym: "pelvic appendage" RELATED []
is_a: UBERON:0002101 ! limb
is_a: UBERON:0004709 ! pelvic appendage
intersection_of: UBERON:0002101 ! limb
intersection_of: part_of UBERON:0010709 ! pelvic complex
relationship: develops_from UBERON:0005418 ! hindlimb bud
relationship: part_of UBERON:0000154 ! posterior region of body
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0002104
name: visual system
def: "The sensory system subserving the sense of vision." []
synonym: "photosensory system" EXACT []
synonym: "visual organ system" EXACT []
is_a: UBERON:0001032 ! sensory system

[Term]
id: UBERON:0002105
name: vestibulo-auditory system
def: "Sensory system responsible for the perception of spatial orientation and auditory stimuli." []
synonym: "auditory organ system" EXACT []
synonym: "auditory system" RELATED []
synonym: "auditory/vestibular system" RELATED []
synonym: "vestibuloauditory system" EXACT []
synonym: "vestibuloauditory system" RELATED []
is_a: UBERON:0001032 ! sensory system

[Term]
id: UBERON:0002106
name: spleen
def: "the organ that functions to filter blood and to store red corpuscles and platelets" []
synonym: "lien" RELATED []
is_a: UBERON:0004177 ! hemopoietic organ
is_a: UBERON:0005057 ! immune organ
is_a: UBERON:0013765 ! digestive system element
is_a: UBERON:0017672 ! abdominal viscera
relationship: develops_from UBERON:0006293 ! spleen primordium
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0002390 ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: UBERON:0002107
name: liver
def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." []
synonym: "iecur" RELATED []
synonym: "jecur" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005172 ! abdomen element
is_a: UBERON:0006925 ! digestive gland
relationship: develops_from UBERON:0003894 ! liver primordium
relationship: develops_from UBERON:0004161 ! septum transversum
relationship: develops_from UBERON:0008836 ! liver bud
relationship: has_part UBERON:0004647 ! liver lobule
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0002330 ! exocrine system
relationship: part_of UBERON:0002423 ! hepatobiliary system

[Term]
id: UBERON:0002108
name: small intestine
def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." []
synonym: "anterior intestine" RELATED []
synonym: "intestinum tenue" RELATED []
synonym: "mid intestine" RELATED []
synonym: "small bowel" EXACT []
synonym: "small intestine" EXACT []
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0013765 ! digestive system element
relationship: part_of UBERON:0000160 ! intestine

[Term]
id: UBERON:0002110
name: gall bladder
def: "An organ that aids digestion and stores bile produced by the liver[WP]." []
synonym: "gall bladder" EXACT []
synonym: "gallbladder" EXACT []
synonym: "vesica biliaris" RELATED []
synonym: "vesica fellea" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0013765 ! digestive system element
is_a: UBERON:0017672 ! abdominal viscera
is_a: UBERON:0018707 ! bladder organ
relationship: develops_from UBERON:0004912 ! biliary bud
relationship: develops_from UBERON:0006242 ! gall bladder primordium
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0002423 ! hepatobiliary system

[Term]
id: UBERON:0002111
name: artery smooth muscle tissue
def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." []
synonym: "arterial smooth muscle" EXACT []
synonym: "arterial smooth muscle cell" RELATED []
synonym: "artery smooth muscle" EXACT []
synonym: "artery smooth muscle tissue" EXACT []
synonym: "smooth muscle of artery" EXACT []
is_a: UBERON:0004237 ! blood vessel smooth muscle
is_a: UBERON:0004695 ! arterial system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0002112
name: smooth muscle of esophagus
def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." []
synonym: "esophageal smooth muscle" EXACT []
synonym: "esophagus involuntary muscle" EXACT []
synonym: "esophagus non-striated muscle" EXACT []
synonym: "esophagus smooth muscle" EXACT []
synonym: "esophagus smooth muscle tissue" EXACT []
synonym: "gullet involuntary muscle" EXACT []
synonym: "gullet non-striated muscle" EXACT []
synonym: "gullet smooth muscle" EXACT []
synonym: "gullet smooth muscle tissue" EXACT []
synonym: "involuntary muscle of esophagus" EXACT []
synonym: "involuntary muscle of gullet" EXACT []
synonym: "involuntary muscle of oesophagus" EXACT []
synonym: "non-striated muscle of esophagus" EXACT []
synonym: "non-striated muscle of gullet" EXACT []
synonym: "non-striated muscle of oesophagus" EXACT []
synonym: "oesophagus involuntary muscle" EXACT []
synonym: "oesophagus non-striated muscle" EXACT []
synonym: "oesophagus smooth muscle" RELATED []
synonym: "oesophagus smooth muscle tissue" EXACT []
synonym: "smooth muscle of gullet" EXACT []
synonym: "smooth muscle of oesophagus" EXACT []
synonym: "smooth muscle tissue of esophagus" EXACT []
synonym: "smooth muscle tissue of gullet" EXACT []
synonym: "smooth muscle tissue of oesophagus" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0003832 ! esophagus muscle

[Term]
id: UBERON:0002113
name: kidney
def: "A paired organ of the urinary tract which has the production of urine as its primary function." []
synonym: "reniculate kidney" NARROW []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000489 ! cavitated compound organ
is_a: UBERON:0005172 ! abdomen element
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0003918 ! kidney mesenchyme
relationship: develops_from UBERON:0005095 ! kidney rudiment
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0011143 ! upper urinary tract

[Term]
id: UBERON:0002114
name: duodenum
def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." []
synonym: "proximal intestine" RELATED []
synonym: "upper intestine" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0002115
name: jejunum
def: "the portion of the small intestine that extends from the duodenum to the ileum" []
synonym: "intestinum jejunum" RELATED []
synonym: "mid-intestine" RELATED []
synonym: "middle intestine" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001045 ! midgut
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0002116
name: ileum
def: "the portion of the small intestine that extends from the jejunum to the colon" []
synonym: "distal intestine" RELATED []
synonym: "intestinum ileum" RELATED []
synonym: "lower intestine" RELATED []
synonym: "posterior intestine" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0002118
name: right ovary
def: "An ovary that is part of a right side of organism [Automatically generated definition]." []
is_a: UBERON:0000992 ! female gonad
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0002119
name: left ovary
def: "An ovary that is part of a left side of organism [Automatically generated definition]." []
is_a: UBERON:0000992 ! female gonad
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0002120
name: pronephros
def: "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]." []
synonym: "archinephron" RELATED []
synonym: "embryonic kidney" RELATED []
synonym: "pronephric kidney" EXACT []
synonym: "pronephron" RELATED []
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0005095 ! kidney rudiment
relationship: develops_from UBERON:0005721 ! pronephric mesoderm
relationship: develops_from UBERON:0005754 ! rostral part of nephrogenic cord

[Term]
id: UBERON:0002123
name: cortex of thymus
def: "the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" []
synonym: "thymic cortex" EXACT []
synonym: "thymus cortex" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001851 ! cortex
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0002124
name: medulla of thymus
def: "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." []
synonym: "medulla of thymus gland" EXACT []
synonym: "thymus gland medulla" EXACT []
synonym: "thymus medulla" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000958 ! medulla of organ
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0002125
name: thymus lobule
def: "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." []
synonym: "lobule of thymus" EXACT []
synonym: "thymic lobule" EXACT []
synonym: "thymus lobule" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0009911 ! lobule
intersection_of: UBERON:0009911 ! lobule
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0002129
name: cerebellar cortex
def: "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." []
synonym: "cortex cerebellaris" RELATED []
synonym: "cortex cerebelli" RELATED []
synonym: "cortex of cerebellar hemisphere" EXACT []
is_a: UBERON:0019263 ! gray matter of hindbrain
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: UBERON:0002165
name: endocardium
def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." []
synonym: "endocardial lining" EXACT []
synonym: "endocardial tissue" EXACT []
synonym: "heart endocardial tissue" RELATED []
synonym: "heart endocardium" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002523 ! tunica intima
is_a: UBERON:0005983 ! heart layer
is_a: UBERON:0008307 ! heart endothelium
relationship: has_part UBERON:0001986 ! endothelium
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0002166
name: endocardium of atrium
def: "Endocardium that is part of the atrium." []
synonym: "atrial endocardium" EXACT []
synonym: "atrium endocardial tissue" RELATED []
synonym: "atrium endocardium" EXACT []
synonym: "atrium of heart endocardium" EXACT []
synonym: "Cardiac atria endocardium" EXACT []
synonym: "cardiac atrium endocardium" EXACT []
synonym: "endocardium of atrium of heart" EXACT []
synonym: "endocardium of Cardiac atria" EXACT []
synonym: "endocardium of cardiac atrium" EXACT []
synonym: "endocardium of heart atrium" EXACT []
synonym: "heart atrium endocardium" EXACT []
is_a: UBERON:0002165 ! endocardium
intersection_of: UBERON:0002165 ! endocardium
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium

[Term]
id: UBERON:0002167
name: right lung
def: "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]" []
is_a: UBERON:0002048 ! lung

[Term]
id: UBERON:0002168
name: left lung
def: "Lung which consists of the left upper lobe and left lower lobe.[FMA]" []
is_a: UBERON:0002048 ! lung

[Term]
id: UBERON:0002169
name: alveolar sac
def: "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" []
synonym: "air sac" RELATED []
synonym: "pulmonary alveolar sac" EXACT []
synonym: "sacculus alveolaris" EXACT []
is_a: UBERON:0000115 ! lung epithelium
is_a: UBERON:0000117 ! respiratory tube
is_a: UBERON:0007499 ! epithelial sac
intersection_of: UBERON:0007499 ! epithelial sac
intersection_of: part_of UBERON:0008874 ! pulmonary acinus
relationship: part_of UBERON:0006524 ! alveolar system
relationship: part_of UBERON:0008874 ! pulmonary acinus

[Term]
id: UBERON:0002180
name: ventral funiculus of spinal cord
def: "The most lateral of the bundles of the anterior nerve roots is generally taken as a dividing line that separates the antero-lateral region into two parts, viz. , an anterior funiculus, between the anterior median fissure and the most lateral of the anterior nerve roots; and a lateral funiculus, between the exit of these roots and the postero-lateral sulcus. [WP,unvetted]." []
synonym: "anterior funiculus" EXACT []
synonym: "anterior funiculus of spinal cord" EXACT []
synonym: "anterior white column of spinal cord" EXACT []
synonym: "funiculus anterior medullae spinalis" EXACT []
synonym: "ventral funiculi" RELATED []
synonym: "ventral funiculus" EXACT []
synonym: "ventral funiculus of spinal cord" EXACT []
synonym: "ventral white column of spinal cord" EXACT []
is_a: UBERON:0006127 ! funiculus of spinal cord

[Term]
id: UBERON:0002185
name: bronchus
def: "the upper conducting airways of the lung; these airways arise from the terminus of the trachea" []
synonym: "bronchi" EXACT []
synonym: "bronchial tissue" RELATED []
synonym: "bronchial trunk" EXACT []
is_a: UBERON:0000117 ! respiratory tube
relationship: part_of UBERON:0007196 ! tracheobronchial tree

[Term]
id: UBERON:0002186
name: bronchiole
def: "the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching" []
synonym: "bronchioli" RELATED []
synonym: "bronchiolus" RELATED []
synonym: "lobular bronchiole" EXACT []
is_a: UBERON:0000117 ! respiratory tube
relationship: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0007196 ! tracheobronchial tree
relationship: part_of UBERON:0010368 ! pulmonary lobule

[Term]
id: UBERON:0002187
name: terminal bronchiole
def: "the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls" []
synonym: "bronchioli terminalis" RELATED []
synonym: "bronchiolus terminalis" EXACT []
synonym: "terminal bronchiole tube" RELATED []
is_a: UBERON:0002186 ! bronchiole

[Term]
id: UBERON:0002188
name: respiratory bronchiole
def: "A bronchiole that is the first segment of the respiratory zone." []
synonym: "bronchiolus respiratorii" EXACT []
synonym: "bronchiolus respiratorius" EXACT []
is_a: UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0008874 ! pulmonary acinus

[Term]
id: UBERON:0002190
name: subcutaneous adipose tissue
def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." []
synonym: "fatty layer of subcutaneous tissue" EXACT []
synonym: "fatty layer of superficial fascia" RELATED []
synonym: "hypodermis fat layer" EXACT []
synonym: "panniculus adiposus" BROAD []
synonym: "panniculus adiposus (tela subcutanea)" EXACT []
synonym: "panniculus adiposus telae subcutaneae" EXACT []
synonym: "subcutaneous fat" RELATED []
synonym: "subcutaneous fat layer" EXACT []
is_a: UBERON:0001013 ! adipose tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0002191
name: subiculum
def: "Part of the hippocampal formation that is bounded by the entorhinal cortex and area CA1. It is characterized on the CA1 border by an abrupt widening of the pyramidal cell layer. A molecular layer is present that is continuous with that of CA1, although the stratum radiatum is no longer present. The stratum oriens is also not present. adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995, pg. 468)" []
synonym: "gyrus parahippocampalis" RELATED []
synonym: "subicular cortex" EXACT []
synonym: "subiculum cornu ammonis" RELATED []
synonym: "subiculum hippocampi" EXACT []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002421 ! hippocampal formation

[Term]
id: UBERON:0002193
name: hemolymphoid system
def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." []
synonym: "haemolymphoid system" RELATED []
synonym: "hematolymphoid system" EXACT []
synonym: "lymphomyeloid complex" EXACT []
is_a: UBERON:0000467 ! anatomical system

[Term]
id: UBERON:0002194
name: capsule of lymph node
def: "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers." []
synonym: "capsula nodi lymphoidei" EXACT []
synonym: "lymph node capsule" EXACT []
is_a: UBERON:0003893 ! capsule

[Term]
id: UBERON:0002196
name: adenohypophysis
def: "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]." []
synonym: "AHP" BROAD []
synonym: "anterior hypophysis" EXACT []
synonym: "anterior lobe (hypophysis)" EXACT []
synonym: "anterior lobe of hypophysis" EXACT []
synonym: "anterior lobe of pituitary" EXACT []
synonym: "anterior lobe of pituitary gland" EXACT []
synonym: "anterior lobe of the pituitary" RELATED []
synonym: "anterior pituitary" EXACT []
synonym: "anterior pituitary gland" RELATED []
synonym: "cranial lobe" RELATED []
synonym: "lobus anterior" RELATED []
synonym: "lobus anterior (glandula pituitaria)" EXACT []
synonym: "lobus anterior hypophysis" EXACT []
synonym: "pituitary anterior lobe" RELATED []
synonym: "pituitary gland, anterior lobe" EXACT []
synonym: "pituitary glandanterior lobe" RELATED []
synonym: "rostral lobe" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
disjoint_from: UBERON:0002198 ! neurohypophysis
relationship: develops_from UBERON:0009122 ! adenohypophyseal placode
relationship: part_of UBERON:0000007 ! pituitary gland

[Term]
id: UBERON:0002198
name: neurohypophysis
def: "The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon." []
synonym: "infundibular process" EXACT []
synonym: "lobus nervosus" RELATED []
synonym: "lobus nervosus neurohypophysis" EXACT []
synonym: "lobus posterior" RELATED []
synonym: "lobus posterior (glandula pituitaria)" EXACT []
synonym: "lobus posterior hypophysis" EXACT []
synonym: "neural lobe" EXACT []
synonym: "neural lobe of pituitary" EXACT []
synonym: "neural lobe of pituitary gland" EXACT []
synonym: "neuro hypophysis" EXACT []
synonym: "neurohypophysis" EXACT []
synonym: "NHP" BROAD []
synonym: "pituitary gland neural lobe" RELATED []
synonym: "pituitary gland, neural lobe" RELATED []
synonym: "pituitary gland, posterior lobe" EXACT []
synonym: "posterior lobe of hypophysis" RELATED []
synonym: "posterior lobe of pituitary" EXACT []
synonym: "posterior lobe of pituitary gland" EXACT []
synonym: "posterior pituitary" EXACT []
synonym: "posterior pituitary gland" RELATED []
is_a: UBERON:0003296 ! gland of diencephalon
is_a: UBERON:0010134 ! secretory circumventricular organ
relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: part_of UBERON:0000007 ! pituitary gland

[Term]
id: UBERON:0002199
name: integument
def: "The dermis, epidermis and hypodermis." []
synonym: "dermal system" RELATED []
synonym: "dermis plus epidermis plus hypodermis" EXACT []
synonym: "dermoid system" RELATED []
synonym: "Hautsystem@de" RELATED []
synonym: "integumentum commune" EXACT []
synonym: "skin" RELATED []
synonym: "skin and subcutaneous tissue" EXACT []
synonym: "skin plus hypodermis" EXACT []
synonym: "tegument" RELATED []
synonym: "the integument" EXACT []
synonym: "vertebrate integument" RELATED []
is_a: UBERON:0003102 ! surface structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: has_part UBERON:0002072 ! hypodermis
relationship: has_part UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0002200
name: vasculature of head
def: "Vasculature that is part of a head [Automatically generated definition]." []
synonym: "adult head vascular network" EXACT []
synonym: "adult head vasculature" EXACT []
synonym: "cranial vasculature" EXACT []
synonym: "head vascular network" EXACT []
synonym: "head vasculature" RELATED []
synonym: "vascular network of adult head" EXACT []
synonym: "vascular network of head" EXACT []
synonym: "vasculature of adult head" EXACT []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0002201
name: vasculature of trunk
def: "A vasculature that is part of a trunk [Automatically generated definition]." []
synonym: "torso vascular network" EXACT []
synonym: "torso vasculature" EXACT []
synonym: "trunk vascular network" EXACT []
synonym: "trunk vasculature" EXACT []
synonym: "vascular network of torso" EXACT []
synonym: "vascular network of trunk" EXACT []
synonym: "vasculature of torso" EXACT []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0002202
name: submucosa of trachea
def: "A submucosa that is part of a trachea." []
synonym: "submucosa of windpipe" EXACT []
synonym: "submucous layer of trachea" RELATED []
synonym: "trachea submucosa" EXACT []
synonym: "tracheal submucosa" EXACT []
synonym: "windpipe submucosa" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004777 ! respiratory system submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0002203
name: vasculature of eye
def: "Vasculature that is part of the eye region." []
synonym: "eye vascular network" EXACT []
synonym: "eye vasculature" RELATED []
synonym: "ocular blood vessel" EXACT []
synonym: "ocular vasculature" EXACT []
synonym: "optic vasculature" RELATED []
synonym: "vascular network of eye" EXACT []
is_a: UBERON:0002200 ! vasculature of head
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: develops_from UBERON:0003314 ! eye mesenchyme
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0002204
name: musculoskeletal system
def: "Anatomical system that consists of the muscular and skeletal systems." []
synonym: "musculo-skeletal system" EXACT []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0000383 ! musculature of body
relationship: has_part UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0002209
name: fibrous joint
def: "Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA]" []
synonym: "articulatio fibrosa" EXACT []
synonym: "junctura fibrosa" RELATED []
is_a: UBERON:0011134 ! nonsynovial joint

[Term]
id: UBERON:0002212
name: macula of saccule of membranous labyrinth
def: "the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" []
synonym: "macula of membranous labyrinth saccule" EXACT []
synonym: "macula of saccule" EXACT []
synonym: "macula of sacculus (labyrinthus vestibularis)" EXACT []
synonym: "macula saccule" EXACT []
synonym: "macula sacculi" EXACT []
synonym: "macula sacculi" RELATED []
synonym: "membranous labyrinth saccule macula" EXACT []
synonym: "saccular macula" EXACT []
synonym: "saccular macula of membranous labyrinth" EXACT []
synonym: "saccular maculs" RELATED []
synonym: "saccule macula" EXACT []
synonym: "saccule of membranous labyrinth macula" EXACT []
synonym: "sacculus (labyrinthus vestibularis) macula" EXACT []
is_a: UBERON:0000054 ! macula
intersection_of: UBERON:0000054 ! macula
intersection_of: part_of UBERON:0001854 ! saccule of membranous labyrinth
relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth

[Term]
id: UBERON:0002213
name: cartilaginous joint
def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]" []
synonym: "articulatio cartilaginea" EXACT []
synonym: "junctura cartilaginea" RELATED []
is_a: UBERON:0011134 ! nonsynovial joint

[Term]
id: UBERON:0002214
name: macula of utricle of membranous labyrinth
def: "the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" []
synonym: "macula of membranous labyrinth utricle" EXACT []
synonym: "macula of utricle" EXACT []
synonym: "macula of utriculus (labyrinthus vestibularis)" EXACT []
synonym: "macula utricle" EXACT []
synonym: "macula utriculi" EXACT []
synonym: "macula utriculi" RELATED []
synonym: "maculae utricle" RELATED []
synonym: "membranous labyrinth utricle macula" EXACT []
synonym: "utricle macula" EXACT []
synonym: "utricle of membranous labyrinth macula" EXACT []
synonym: "utricular macula" RELATED []
synonym: "utriculus (labyrinthus vestibularis) macula" EXACT []
is_a: UBERON:0000054 ! macula
intersection_of: UBERON:0000054 ! macula
intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth
relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth

[Term]
id: UBERON:0002216
name: symphysis
def: "Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA]" []
synonym: "secondary cartilaginous joint" EXACT []
is_a: UBERON:0002209 ! fibrous joint
is_a: UBERON:0002213 ! cartilaginous joint

[Term]
id: UBERON:0002217
name: synovial joint
def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]" []
synonym: "articulatio synoviale" EXACT []
synonym: "diarthrodial joints" RELATED []
synonym: "diarthroses" EXACT []
synonym: "diarthrosis" EXACT []
synonym: "diarthrosis joint" EXACT []
is_a: UBERON:0000982 ! skeletal joint
disjoint_from: UBERON:0011134 ! nonsynovial joint

[Term]
id: UBERON:0002227
name: spiral organ of cochlea
def: "The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." []
synonym: "auditory papilla" RELATED []
synonym: "auditory papillae" RELATED []
synonym: "basilar papilla" RELATED []
synonym: "cochlear spiral organ" EXACT []
synonym: "Corti's organ" RELATED []
synonym: "organ of Corti" RELATED []
synonym: "organum spirale" EXACT []
synonym: "papilla basilaris" RELATED []
synonym: "spiral organ" EXACT []
synonym: "spiral organ of Corti" EXACT []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth

[Term]
id: UBERON:0002240
name: spinal cord
def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)" []
synonym: "cerebro-cerebellar fissure" RELATED []
synonym: "cerebrocerebellar fissure" RELATED []
synonym: "fissura cerebro-cerebellaris" RELATED []
synonym: "fissura cerebrocerebellaris" RELATED []
synonym: "medulla spinalis" RELATED []
synonym: "SpC" RELATED []
synonym: "spinal cord structure" RELATED []
synonym: "spinal medulla" RELATED []
is_a: UBERON:0000489 ! cavitated compound organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005174 ! dorsal region element
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0003076 ! posterior neural tube
relationship: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0002241
name: chondrocranium
def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." []
synonym: "calvarium" RELATED []
synonym: "neurocranium" RELATED []
is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system

[Term]
id: UBERON:0002242
name: nucleus pulposus
def: "the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" []
synonym: "nucleus propulsus" RELATED []
synonym: "nucleus propulsus of intervertebral disk" RELATED []
synonym: "nucleus pulposus (diskus intervertebralis)" EXACT []
synonym: "nucleus pulposus of intervertebral disk" RELATED []
synonym: "pulpy nucleus" EXACT []
is_a: UBERON:0002384 ! connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0002328 ! notochord
relationship: has_part UBERON:0011860 ! collection of collagen fibrils
relationship: part_of UBERON:0001066 ! intervertebral disk

[Term]
id: UBERON:0002255
name: vomeronasal organ
def: "An organ thought to supplement the olfactory system in receiving pheromonic communication. The sensory part of the organ is in two long, thin sacs, situated on either side of the nasal septum at its base." []
synonym: "Jacobson's organ" EXACT []
synonym: "organ of Jacobsen" RELATED []
synonym: "organon vomeronasale" EXACT []
synonym: "organum vomeronasale" EXACT []
synonym: "VNO" RELATED []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0003050 ! olfactory placode
relationship: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0009954 ! vomeronasal system

[Term]
id: UBERON:0002256
name: dorsal horn of spinal cord
def: "The pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO]." []
synonym: "columna grisea posterior medullae spinalis" EXACT []
synonym: "cornu dorsale" EXACT []
synonym: "cornu posterius medullae spinalis" EXACT []
synonym: "dorsal gray column of spinal cord" EXACT []
synonym: "dorsal gray horn" EXACT []
synonym: "dorsal gray matter of spinal cord" EXACT []
synonym: "dorsal grey column of spinal cord" EXACT []
synonym: "dorsal grey horn" BROAD []
synonym: "dorsal horn" BROAD []
synonym: "dorsal horn of the spinal cord" RELATED []
synonym: "dorsal horn spinal cord" EXACT []
synonym: "dorsal region of mature spinal cord" BROAD []
synonym: "dorsal region of spinal cord" BROAD []
synonym: "dorsal spinal cord" BROAD []
synonym: "posterior gray column of spinal cord" EXACT []
synonym: "posterior gray horn of spinal cord" EXACT []
synonym: "posterior grey column of spinal cord" EXACT []
synonym: "posterior horn of spinal cord" EXACT []
synonym: "spinal cord dorsal horn" EXACT []
synonym: "spinal cord dorsal horns" RELATED []
synonym: "spinal cord posterior horn" EXACT []
is_a: UBERON:0016550 ! spinal cord column
disjoint_from: UBERON:0002257 ! ventral horn of spinal cord
relationship: part_of UBERON:0002315 ! gray matter of spinal cord

[Term]
id: UBERON:0002257
name: ventral horn of spinal cord
def: "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." []
synonym: "anterior column" RELATED []
synonym: "anterior column of the spinal cord" RELATED []
synonym: "anterior gray column of spinal cord" EXACT []
synonym: "anterior gray horn of spinal cord" EXACT []
synonym: "anterior grey column of spinal cord" EXACT []
synonym: "anterior horn" EXACT []
synonym: "anterior horn (spinal cord)" RELATED []
synonym: "columna grisea anterior medullae spinalis" EXACT []
synonym: "cornu anterius medullae spinalis" RELATED []
synonym: "spinal cord anterior horn" EXACT []
synonym: "spinal cord ventral horn" EXACT []
synonym: "ventral gray column of spinal cord" EXACT []
synonym: "ventral gray matter of spinal cord" EXACT []
synonym: "ventral grey column of spinal cord" EXACT []
synonym: "ventral grey horn" EXACT []
synonym: "ventral horn of the spinal cord" RELATED []
synonym: "ventral horn spinal cord" EXACT []
synonym: "ventral horns spinal cord" RELATED []
synonym: "ventral region of spinal cord" EXACT []
synonym: "ventral spinal cord" EXACT []
is_a: UBERON:0016550 ! spinal cord column
relationship: part_of UBERON:0002315 ! gray matter of spinal cord

[Term]
id: UBERON:0002264
name: olfactory bulb
def: "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]." []
synonym: "bulbus olfactorius" EXACT []
synonym: "bulbus olfactorius" RELATED []
synonym: "bulbus olfactorius (Morgagni)" RELATED []
synonym: "olfactory lobe" RELATED []
synonym: "olfactory lobe (Barr & Kiernan)" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0005366 ! olfactory lobe

[Term]
id: UBERON:0002268
name: olfactory organ
def: "An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ." []
synonym: "main olfactory organ" NARROW []
synonym: "olfactory neuroepithelium" RELATED []
synonym: "olfactory organ" EXACT []
synonym: "olfactory sense organ" EXACT []
synonym: "olfactory sensory organ" EXACT []
synonym: "organ olfactus" RELATED []
synonym: "organum olfactorium" RELATED []
synonym: "primary olfactory organ" NARROW []
is_a: UBERON:0000020 ! sense organ

[Term]
id: UBERON:0002271
name: periventricular zone of hypothalamus
synonym: "hypothalamus periventricular zone" EXACT []
synonym: "Periventricular zone of the hypothalamus" RELATED []
synonym: "zona periventricularis hypothalamicae" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001898 ! hypothalamus

[Term]
id: UBERON:0002275
name: reticular formation
def: "The term reticular formation (classical) denotes a composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." []
synonym: "brain stem reticular formation" EXACT []
synonym: "brainstem reticular formation" EXACT []
synonym: "reticular formation (classical)" EXACT []
synonym: "reticular formation of the brainstem" EXACT []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002298 ! brainstem

[Term]
id: UBERON:0002276
name: lamina of spiral limbus
def: "The osseous spiral lamina consists of two plates of bone, and between these are the canals for the transmission of the filaments of the acoustic nerve. On the upper plate of that part of the lamina which is outside the vestibular membrane, the periosteum is thickened to form the limbus spiralis (or limbus laminæ spiralis), this ends externally in a concavity, the sulcus spiralis internus, which represents, on section, the form of the letter C. [WP,unvetted]." []
synonym: "limbus lamina spiralis" EXACT []
synonym: "limbus laminae spiralis" EXACT []
synonym: "limbus laminae spiralis osseae" EXACT []
synonym: "spiral limbus" RELATED []
synonym: "spiral limbus lamina" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth

[Term]
id: UBERON:0002282
name: stria vascularis of cochlear duct
def: "The upper portion of the spiral ligament contains numerous capillary loops and small blood vessels, and is termed the stria vascularis. It produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [WP,unvetted]." []
synonym: "psalterial cord" EXACT []
synonym: "stria vascularis" EXACT []
synonym: "stria vascularis ductus cochlearis" RELATED []
synonym: "stria vascularis of cochlea" EXACT []
synonym: "vascular stria of cochlear duct" RELATED []
synonym: "vascular stripe of cochlear duct" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth

[Term]
id: UBERON:0002285
name: telencephalic ventricle
def: "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere" []
synonym: "forebrain ventricle" RELATED []
synonym: "lateral ventricle" EXACT []
synonym: "lateral ventricle of brain" RELATED []
synonym: "lateral ventricles" EXACT []
synonym: "tectal ventricle" RELATED []
synonym: "telencephalic ventricle" EXACT []
synonym: "Telencephalic ventricles" RELATED []
synonym: "telencephalic vesicle" RELATED []
synonym: "telencephalon lateral ventricle" EXACT []
is_a: UBERON:0004086 ! brain ventricle
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0004086 ! brain ventricle
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0002290
name: choroid plexus of fourth ventricle
def: "Choroid plexus of the fourth ventricle" []
synonym: "4th ventricle choroid plexus" RELATED []
synonym: "chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT []
synonym: "chorioid plexus of fourth ventricle" EXACT []
synonym: "choroid plexus fourth ventricle" EXACT []
synonym: "fourth ventricle chorioid plexus of cerebral hemisphere" EXACT []
synonym: "fourth ventricle choroid plexus" EXACT []
is_a: UBERON:0001886 ! choroid plexus
is_a: UBERON:0006694 ! cerebellum vasculature
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001886 ! choroid plexus
intersection_of: part_of UBERON:0002422 ! fourth ventricle
relationship: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002422 ! fourth ventricle

[Term]
id: UBERON:0002294
name: biliary system
def: "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." []
synonym: "biliary apparatus" EXACT []
synonym: "biliary tract" RELATED []
is_a: UBERON:0011216 ! organ system subdivision
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0001173 ! biliary tree
relationship: part_of UBERON:0002423 ! hepatobiliary system

[Term]
id: UBERON:0002296
name: dorsal mesentery
def: "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." []
synonym: "dorsal mesogastrium" RELATED []
synonym: "mesenterium dorsale commune" RELATED []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0009664 ! gut mesentery

[Term]
id: UBERON:0002298
name: brainstem
def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." []
synonym: "accessory medullary lamina of pallidum" RELATED []
synonym: "brain stem" EXACT []
synonym: "lamella pallidi incompleta" RELATED []
synonym: "lamina medullaris accessoria" RELATED []
synonym: "lamina medullaris incompleta pallidi" RELATED []
synonym: "lamina pallidi incompleta" RELATED []
synonym: "truncus encephali" EXACT []
synonym: "truncus encephalicus" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0001896 ! medulla oblongata
relationship: has_part UBERON:0001943 ! midbrain tegmentum
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0002299
name: alveolus of lung
def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." []
synonym: "alveoli" RELATED []
synonym: "alveolus" BROAD []
synonym: "alveolus pulmonis" EXACT []
synonym: "alveolus pulmonis" RELATED []
synonym: "lung alveolus" EXACT []
synonym: "pulmonary alveolus" EXACT []
synonym: "respiratory alveoli" RELATED []
synonym: "respiratory alveolus" EXACT []
is_a: UBERON:0003215 ! alveolus
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0003215 ! alveolus
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002169 ! alveolar sac
relationship: part_of UBERON:0006524 ! alveolar system

[Term]
id: UBERON:0002301
name: layer of neocortex
def: "One of the layers of the neocortex." []
synonym: "cerebral cortex layer" RELATED []
synonym: "cortical layer" BROAD []
synonym: "lamina of neocortex" RELATED []
synonym: "layer of neocortex" EXACT []
synonym: "neocortex layer" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0022303 ! nervous system cell part layer
intersection_of: UBERON:0022303 ! nervous system cell part layer
intersection_of: part_of UBERON:0001950 ! neocortex
relationship: part_of UBERON:0001950 ! neocortex

[Term]
id: UBERON:0002302
name: myocardium of atrium
def: "the atrial part of middle layer of the heart, comprised of involuntary muscle" []
synonym: "atrial myocardium" EXACT []
synonym: "atrium cardiac muscle" RELATED []
synonym: "atrium myocardium" EXACT []
is_a: UBERON:0002349 ! myocardium
intersection_of: UBERON:0002349 ! myocardium
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium

[Term]
id: UBERON:0002303
name: juxtaglomerular apparatus
def: "An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." []
synonym: "complexus juxtaglomerularis" EXACT []
synonym: "juxtaglomerular complex" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000477 ! anatomical cluster
relationship: has_part UBERON:0002335 ! macula densa
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0002304
name: layer of dentate gyrus
def: "One of the three layers of the dentate gyrus of the hippocampal formation." []
synonym: "dentate gyrus cell layer" EXACT []
synonym: "dentate gyrus layer" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0022303 ! nervous system cell part layer
intersection_of: UBERON:0022303 ! nervous system cell part layer
intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation
relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation

[Term]
id: UBERON:0002305
name: layer of hippocampus
def: "The layers of the laminar structure of the hippocampus." []
synonym: "cytoarchitectural fields of hippocampal formation" EXACT []
synonym: "hippocampus layer" EXACT []
synonym: "hippocampus proper layer" RELATED []
synonym: "layer of cornu ammonis" RELATED []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0016548 ! central nervous system gray matter layer
intersection_of: UBERON:0016548 ! central nervous system gray matter layer
intersection_of: part_of UBERON:0002421 ! hippocampal formation
relationship: part_of UBERON:0002421 ! hippocampal formation

[Term]
id: UBERON:0002307
name: choroid plexus of lateral ventricle
def: "Part of choroid plexus contained in the lateral ventricle" []
synonym: "chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT []
synonym: "chorioid plexus of lateral ventricle" EXACT []
synonym: "choroid plexus telencephalic ventricle" EXACT []
synonym: "lateral ventricle chorioid plexus of cerebral hemisphere" EXACT []
synonym: "lateral ventricle choroid plexus" EXACT []
is_a: UBERON:0001886 ! choroid plexus
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001886 ! choroid plexus
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle

[Term]
id: UBERON:0002308
name: nucleus of brain
def: "A neural nucleus that is part of the brain." []
synonym: "brain nuclei" RELATED []
synonym: "brain nucleus" EXACT []
is_a: UBERON:0000125 ! neural nucleus
intersection_of: UBERON:0000125 ! neural nucleus
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0003528 ! brain gray matter

[Term]
id: UBERON:0002313
name: hippocampus pyramidal layer
def: "A cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3 (Stephan-75) (NeuroNames)." []
synonym: "gyrus occipitalis inferior" RELATED []
synonym: "gyrus occipitalis tertius" RELATED []
synonym: "hippocampal pyramidal cell layer" RELATED []
synonym: "hippocampal pyramidal layer" RELATED []
synonym: "hippocampus pyramidal cell layer" RELATED []
synonym: "hippocampus stratum pyramidale" RELATED []
synonym: "pyramidal cell layer of the hippocampus" EXACT []
synonym: "pyramidal layer of hippocampus" EXACT []
synonym: "stratum pyramidale" EXACT []
synonym: "stratum pyramidale hippocampi" EXACT []
is_a: UBERON:0002305 ! layer of hippocampus

[Term]
id: UBERON:0002315
name: gray matter of spinal cord
def: "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." []
synonym: "gray matter of spinal cord" EXACT []
synonym: "gray substance of spinal cord" EXACT []
synonym: "grey matter of spinal cord" EXACT []
synonym: "grey substance of spinal cord" EXACT []
synonym: "spinal cord gray matter" EXACT []
synonym: "spinal cord grey matter" EXACT []
synonym: "spinal cord grey substance" EXACT []
synonym: "substantia grisea medullae spinalis" EXACT []
is_a: UBERON:0002020 ! gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0002316
name: white matter
def: "Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system." []
synonym: "CNS tract/commissure" EXACT []
synonym: "CNS tracts and commissures" RELATED []
synonym: "CNS white matter" RELATED []
synonym: "neuronal white matter" EXACT []
synonym: "substantia alba" RELATED []
synonym: "white mater" RELATED []
synonym: "white matter of neuraxis" EXACT []
synonym: "white substance" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0002318
name: white matter of spinal cord
def: "The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." []
synonym: "spinal cord white matter" EXACT []
synonym: "spinal cord white matter of neuraxis" EXACT []
synonym: "spinal cord white substance" EXACT []
synonym: "substantia alba medullae spinalis" EXACT []
synonym: "white matter of neuraxis of spinal cord" EXACT []
synonym: "white substance of spinal cord" EXACT []
is_a: UBERON:0002316 ! white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0002319
name: mesangium
def: "inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." []
is_a: UBERON:0000119 ! cell layer
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0005215 ! kidney interstitium

[Term]
id: UBERON:0002320
name: glomerular mesangium
def: "A thin membrane which helps to support the capillary loops in a renal glomerulus. It is connective tissue composed of mesangial cells - myofibroblasts phenotypically related to vascular smooth muscle cells (MUSCLE, SMOOTH, VASCULAR), PHAGOCYTES and the mesangial EXTRACELLULAR MATRIX." []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0002319 ! mesangium
relationship: part_of UBERON:0004190 ! renal glomerulus vasculature

[Term]
id: UBERON:0002321
name: extraglomerular mesangium
def: "the tissue comprised of mesangial cells that fill the triangular space between the macula densa and the afferent and efferent arterioles of the juxtaglomerular apparatus" []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus
relationship: part_of UBERON:0002319 ! mesangium

[Term]
id: UBERON:0002323
name: coelemic cavity lumen
def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." []
synonym: "body cavity" BROAD []
synonym: "celom" RELATED []
synonym: "coelom" RELATED []
synonym: "coelome" RELATED []
synonym: "coelomic cavity" EXACT []
synonym: "coelomic cavity lumen" EXACT []
synonym: "hemocoel" RELATED []
synonym: "main body cavity" EXACT []
synonym: "space of body compartment" EXACT []
synonym: "ventral body cavity" NARROW []
is_a: UBERON:0002553 ! anatomical cavity

[Term]
id: UBERON:0002324
name: muscle of back
def: "Any muscle organ that is part of a back [Automatically generated definition]." []
synonym: "back muscle" EXACT []
synonym: "back muscle organ" EXACT []
synonym: "muscle organ of back" EXACT []
is_a: UBERON:0001774 ! skeletal muscle of trunk
is_a: UBERON:0005174 ! dorsal region element
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0004469 ! musculature of back

[Term]
id: UBERON:0002325
name: epithelium of urethra
def: "The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.." []
synonym: "epithelial tissue of urethra" EXACT []
synonym: "urethra epithelial tissue" EXACT []
synonym: "urethra epithelium" EXACT []
synonym: "urethral epithelium" RELATED []
synonym: "urethral plate" RELATED []
synonym: "urethral seam" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0006555 ! excretory tube
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0002326
name: lamina propria of urethra
def: "A lamina propria that is part of a urethra [Automatically generated definition]." []
synonym: "lamina propria mucosa of urethra" EXACT []
synonym: "lamina propria mucosae of urethra" EXACT []
synonym: "urethra lamina propria" EXACT []
synonym: "urethra lamina propria mucosa" EXACT []
synonym: "urethra lamina propria mucosae" EXACT []
synonym: "urethral lamina propria" RELATED []
is_a: UBERON:0000030 ! lamina propria
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0002328
name: notochord
def: "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." []
synonym: "embryonic notocord" EXACT []
synonym: "notochorda" RELATED []
synonym: "notocord" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0004880 ! chordamesoderm
relationship: develops_from UBERON:0006267 ! notochordal plate
relationship: part_of UBERON:0011137 ! axial skeletal system

[Term]
id: UBERON:0002329
name: somite
def: "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." []
synonym: "epimere" RELATED []
synonym: "epimere mesoderm" RELATED []
synonym: "epithelial somite" RELATED []
synonym: "mesodermal cluster" BROAD []
synonym: "somites" RELATED []
synonym: "somitic mesoderm" RELATED []
synonym: "somitus" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
is_a: UBERON:0007503 ! epithelial vesicle
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003059 ! presomitic mesoderm

[Term]
id: UBERON:0002330
name: exocrine system
def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." []
synonym: "exocrine glandular system" EXACT []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0002331
name: umbilical cord
def: "The connecting cord from the developing embryo to the placenta." []
synonym: "birth cord" RELATED []
synonym: "chorda umbilicalis" EXACT []
synonym: "connecting stalk" RELATED []
synonym: "funiculus umbilicalis" EXACT []
synonym: "funiculus umbilicalis" RELATED []
synonym: "yolk stalk" RELATED []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0007806 ! connecting stalk

[Term]
id: UBERON:0002335
name: macula densa
def: "The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus[GO]." []
is_a: UBERON:0008408 ! distal tubular epithelium
relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus
relationship: part_of UBERON:0004135 ! distal tubule

[Term]
id: UBERON:0002337
name: endometrial stroma
def: "The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle." []
synonym: "endometrium stroma" EXACT []
synonym: "stroma of endometrium" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium

[Term]
id: UBERON:0002338
name: lamina propria of bronchus
def: "A lamina propria that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi lamina propria" EXACT []
synonym: "bronchi lamina propria mucosa" EXACT []
synonym: "bronchi lamina propria mucosae" EXACT []
synonym: "bronchial lamina propria" RELATED []
synonym: "bronchial trunk lamina propria" EXACT []
synonym: "bronchial trunk lamina propria mucosa" EXACT []
synonym: "bronchial trunk lamina propria mucosae" EXACT []
synonym: "bronchus lamina propria" EXACT []
synonym: "bronchus lamina propria mucosa" EXACT []
synonym: "bronchus lamina propria mucosae" EXACT []
synonym: "lamina propria mucosa of bronchi" EXACT []
synonym: "lamina propria mucosa of bronchial trunk" EXACT []
synonym: "lamina propria mucosa of bronchus" EXACT []
synonym: "lamina propria mucosae of bronchi" EXACT []
synonym: "lamina propria mucosae of bronchial trunk" EXACT []
synonym: "lamina propria mucosae of bronchus" EXACT []
synonym: "lamina propria of bronchi" EXACT []
synonym: "lamina propria of bronchial trunk" EXACT []
is_a: UBERON:0000031 ! lamina propria of trachea
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0000410 ! bronchial mucosa
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0002342
name: neural crest
def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." []
synonym: "crista neuralis" RELATED []
synonym: "NC" EXACT []
synonym: "neural crest material" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010316 ! germ layer / neural crest
relationship: develops_from UBERON:0003075 ! neural plate
relationship: develops_from UBERON:0005062 ! neural fold
relationship: part_of UBERON:0002346 ! neurectoderm

[Term]
id: UBERON:0002343
name: abdomen musculature
def: "Set of all muscles in abdomen." []
synonym: "abdominal musculature" EXACT []
synonym: "muscle group of abdomen" EXACT []
synonym: "muscles of abdomen" EXACT []
synonym: "musculature of abdomen" EXACT []
synonym: "musculature of abdominal wall" EXACT []
synonym: "set of muscles of abdomen" EXACT []
is_a: UBERON:0004479 ! musculature of trunk
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0002346
name: neurectoderm
def: "Embryonic ectoderm that gives rise to nervous tissue." []
synonym: "epithelium tubi neuralis; neuroectoderma" RELATED []
synonym: "neuaral ectoderm" RELATED []
synonym: "neural ectoderm" EXACT []
synonym: "neuroectoderm" EXACT []
synonym: "presumptive central nervous system" RELATED []
synonym: "ventral neurogenic region" RELATED []
is_a: UBERON:0000923 ! germ layer
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0002348
name: epicardium
def: "a region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." []
synonym: "heart epicardium" EXACT []
synonym: "pericardium visceral mesothelium" RELATED []
synonym: "visceral serous pericardium of heart" EXACT []
synonym: "visceral serous pericardium proper" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004160 ! proepicardium
relationship: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0002425 ! visceral serous pericardium

[Term]
id: UBERON:0002349
name: myocardium
def: "the middle layer of the heart, comprised mainly of striated cardiac muscle fibers" []
synonym: "cardiac muscle" RELATED []
synonym: "heart muscle" RELATED []
synonym: "heart myocardium" EXACT []
synonym: "muscle of heart" EXACT []
is_a: UBERON:0005983 ! heart layer
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0018260 ! layer of muscle tissue
relationship: has_part UBERON:0002350 ! conducting system of heart
relationship: part_of UBERON:0000383 ! musculature of body
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0002350
name: conducting system of heart
def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]" []
synonym: "cardiac conducting system" EXACT []
synonym: "cardiac conduction system" EXACT []
synonym: "cardiac impulse conducting system" EXACT []
synonym: "cardionector" EXACT []
synonym: "central conduction system" RELATED []
synonym: "complexus stimulans cordis" EXACT []
synonym: "heart conduction system" EXACT []
synonym: "impulse conducting system" EXACT []
synonym: "systema conducente cordis" EXACT []
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
is_a: UBERON:0010131 ! conducting tissue of heart
relationship: part_of UBERON:0002349 ! myocardium

[Term]
id: UBERON:0002351
name: sinoatrial node
def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." []
synonym: "cardiac pacemaker" EXACT []
synonym: "Koch's node" EXACT []
synonym: "node of Keith-Flack" EXACT []
synonym: "nodus sinuatrialis" EXACT []
synonym: "nodus sinuatrialis" RELATED []
synonym: "SA nodal muscle tissue" EXACT []
synonym: "SA node" EXACT []
synonym: "sinoatrial node" EXACT []
synonym: "sinu-atrial node" EXACT []
synonym: "sinuatrial nodal muscle tissue" EXACT []
synonym: "sinuatrial node" EXACT []
synonym: "sinus node" EXACT []
synonym: "sinus node of Keith and Flack" EXACT []
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
is_a: UBERON:0010131 ! conducting tissue of heart
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0002352
name: atrioventricular node
def: "Subdivision of conducting system of heart which is located in the muscular part of the interatrial septum that is continuous with the atrioventricular bundle.[FMA]" []
synonym: "A-V node" RELATED []
synonym: "aschoff-tawara node" EXACT []
synonym: "atrio-ventricular node" RELATED []
synonym: "atrioventricular nodal muscle tissue" EXACT []
synonym: "atriovetricular node" RELATED []
synonym: "AV nodal muscle tissue" EXACT []
synonym: "AV node" EXACT []
synonym: "downstream pacemaker" RELATED []
synonym: "node of Tawara" EXACT []
synonym: "nodus atrioventricularis" RELATED []
is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
is_a: UBERON:0010131 ! conducting tissue of heart
relationship: part_of UBERON:0002085 ! interatrial septum
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0002353
name: atrioventricular bundle
def: "A part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers[GO]" []
synonym: "A-V bundle" RELATED []
synonym: "atrio-ventricular bundle" RELATED []
synonym: "atrioventricular bundle muscle tissue" EXACT []
synonym: "atrioventricular fasciculus" EXACT []
synonym: "AV bundle" EXACT []
synonym: "bundle of His" EXACT []
synonym: "fasciculus atrioventricularis" EXACT []
synonym: "His bundle" EXACT []
is_a: UBERON:0010131 ! conducting tissue of heart
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: part_of UBERON:0002350 ! conducting system of heart
relationship: part_of UBERON:0004146 ! His-Purkinje system

[Term]
id: UBERON:0002355
name: pelvic region of trunk
def: "The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs." []
synonym: "lesser pelvis" EXACT []
synonym: "pelvic region" EXACT []
synonym: "pelvis" EXACT []
synonym: "pelvis region" EXACT []
synonym: "true pelvis" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0002357
name: serous pericardium
def: "Serous membrane which is divided into parietal and visceral serous pericardium." []
synonym: "pericardium serosum" RELATED []
synonym: "serous portion of pericardium" EXACT []
is_a: UBERON:0000042 ! serous membrane
relationship: has_part UBERON:0002408 ! parietal serous pericardium
relationship: has_part UBERON:0002425 ! visceral serous pericardium
relationship: part_of UBERON:0002406 ! pericardial sac

[Term]
id: UBERON:0002358
name: peritoneum
def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." []
synonym: "peritonaeum" RELATED []
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0035820 ! peritoneal sac
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0003697 ! abdominal wall
relationship: part_of UBERON:0035820 ! peritoneal sac

[Term]
id: UBERON:0002359
name: fibrous pericardium
def: "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]" []
synonym: "fibrous portion of pericardium" EXACT []
synonym: "pericardium fibrosum" RELATED []
is_a: UBERON:0000094 ! membrane organ
is_a: UBERON:0005181 ! thoracic segment organ
relationship: part_of UBERON:0002407 ! pericardium

[Term]
id: UBERON:0002360
name: meninx
def: "Membrane organ that surrounds the brain and the spinal cord." []
synonym: "layer of meninges" EXACT []
synonym: "meningeal layer" EXACT []
synonym: "meninx primitiva" NARROW []
is_a: UBERON:0000094 ! membrane organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0010743 ! meningeal cluster

[Term]
id: UBERON:0002363
name: dura mater
def: "Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections." []
synonym: "dura" RELATED []
synonym: "dura mater of neuraxis" EXACT []
synonym: "pachymeninges" EXACT []
is_a: UBERON:0002360 ! meninx
is_a: UBERON:0004120 ! mesoderm-derived structure

[Term]
id: UBERON:0002364
name: tympanic membrane
def: "A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted]." []
synonym: "ear drum" EXACT []
synonym: "eardrum" EXACT []
synonym: "lateral wall of tympanic cavity" EXACT []
synonym: "membranous wall of tympanic cavity" EXACT []
synonym: "myrinx" EXACT []
synonym: "paries membranaceus cavi tympani" EXACT []
synonym: "Rivinus' membrane" EXACT []
synonym: "tympanum" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000094 ! membrane organ
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0009213 ! pharyngeal membrane of 1st arch
relationship: has_part UBERON:0005042 ! inner epithelial layer of tympanic membrane
relationship: has_part UBERON:0010069 ! outer epithelial layer of tympanic membrane
relationship: has_part UBERON:0010070 ! intermediate layer of tympanic membrane
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0002365
name: exocrine gland
def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" []
synonym: "ducted gland" EXACT []
synonym: "glandula exocrina" EXACT []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0002330 ! exocrine system
relationship: has_part UBERON:0000058 ! duct
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0002367
name: prostate gland
def: "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." []
synonym: "male prostate" EXACT []
synonym: "prostata" RELATED []
synonym: "prostate" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0010147 ! male accessory sex gland
relationship: develops_from UBERON:0003820 ! prostate bud

[Term]
id: UBERON:0002368
name: endocrine gland
def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." []
synonym: "ductless gland" EXACT []
synonym: "ductless gland" RELATED []
synonym: "glandula endocrina" EXACT []
synonym: "glandulae endocrinae" RELATED []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0002369
name: adrenal gland
def: "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." []
synonym: "adrenal" RELATED []
synonym: "adrenal capsule" RELATED []
synonym: "adrenal medulla cell" RELATED []
synonym: "atrabiliary capsule" RELATED []
synonym: "epinephric gland" RELATED []
synonym: "epinephros" RELATED []
synonym: "glandula adrenalis" EXACT []
synonym: "glandula suprarenalis" EXACT []
synonym: "glandula suprarenalis" RELATED []
synonym: "interrenal gland" RELATED []
synonym: "suprarenal capsule" RELATED []
synonym: "suprarenal gland" RELATED []
is_a: UBERON:0005172 ! abdomen element
is_a: UBERON:0006858 ! adrenal/interrenal gland
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0002370
name: thymus
def: "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." []
synonym: "thymus gland" EXACT []
synonym: "thymus organ" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0002368 ! endocrine gland
is_a: UBERON:0004177 ! hemopoietic organ
is_a: UBERON:0005057 ! immune organ
is_a: UBERON:0005058 ! hemolymphoid system gland
relationship: develops_from UBERON:0005562 ! thymus primordium
relationship: has_part UBERON:0003483 ! thymus lymphoid tissue
relationship: has_part UBERON:0003846 ! thymus epithelium
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0002390 ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: UBERON:0002371
name: bone marrow
def: "the soft tissue that fills the cavities of bones" []
synonym: "medulla of bone" RELATED []
synonym: "medulla ossea" EXACT []
synonym: "medulla ossium" EXACT []
is_a: UBERON:0012429 ! hemopoietic tissue
relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: UBERON:0002372
name: tonsil
def: "either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx" []
synonym: "Mandel" RELATED []
is_a: UBERON:0001962 ! gut-associated lymphoid tissue
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: part_of UBERON:0001735 ! tonsillar ring

[Term]
id: UBERON:0002376
name: cranial muscle
def: "Any muscle that is part of the head region." []
synonym: "adult head muscle organ" EXACT []
synonym: "cephalic muscle" EXACT []
synonym: "cephalic musculature" EXACT []
synonym: "cranial muscle" RELATED []
synonym: "head muscle" EXACT []
synonym: "head muscle organ" EXACT []
synonym: "head muscles" RELATED []
synonym: "muscle of head" EXACT []
synonym: "muscle organ of adult head" EXACT []
synonym: "muscle organ of head" EXACT []
synonym: "musculus caput" EXACT []
is_a: UBERON:0010959 ! craniocervical muscle
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0004461 ! musculature of head

[Term]
id: UBERON:0002378
name: muscle of abdomen
def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." []
synonym: "abdomen muscle" EXACT []
synonym: "abdomen muscle organ" EXACT []
synonym: "abdominal muscle" EXACT []
synonym: "abdominal wall muscle" EXACT []
synonym: "abdominal wall musculature" RELATED []
synonym: "muscle organ of abdomen" EXACT []
is_a: UBERON:0003833 ! abdominal segment muscle
is_a: UBERON:0005172 ! abdomen element
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0002343 ! abdomen musculature
relationship: part_of UBERON:0003697 ! abdominal wall

[Term]
id: UBERON:0002381
name: pectoralis major
def: "The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted]." []
synonym: "Musculus pectoralis major" RELATED []
synonym: "pectoralis major muscle" EXACT []
synonym: "pectoralis major muscle structure" EXACT []
is_a: UBERON:0001482 ! muscle of shoulder
is_a: UBERON:0001495 ! pectoral muscle
is_a: UBERON:0003897 ! axial muscle

[Term]
id: UBERON:0002384
name: connective tissue
def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." []
synonym: "Bindegewebe" RELATED []
synonym: "portion of connective tissue" EXACT []
synonym: "textus connectivus" EXACT []
is_a: UBERON:0000479 ! tissue

[Term]
id: UBERON:0002385
name: muscle tissue
def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." []
synonym: "muscular tissue" EXACT []
synonym: "portion of muscle tissue" EXACT []
synonym: "textus muscularis" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0001015 ! musculature

[Term]
id: UBERON:0002387
name: pes
def: "distal portion of the hind limb, including tarsal region, metatarsal region and digits." []
synonym: "foot" EXACT []
synonym: "hind foot" NARROW []
synonym: "hind limb autopodium" RELATED []
synonym: "hind paw" NARROW []
synonym: "hind-paw" NARROW []
synonym: "hindfeet" NARROW []
synonym: "hindfoot" NARROW []
synonym: "hindfoot of quadruped" NARROW []
synonym: "hindlimb autopod" EXACT []
synonym: "hindlimb autopodium" EXACT []
synonym: "hindlimb distal free limb segment" EXACT []
synonym: "hindpaw" NARROW []
synonym: "pes" EXACT []
synonym: "terminal segment of free lower limb" EXACT []
is_a: UBERON:0002470 ! autopod region
is_a: UBERON:0008784 ! lower limb segment
intersection_of: UBERON:0002470 ! autopod region
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: develops_from UBERON:0006871 ! footplate
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0002389
name: manual digit
def: "A digit that is part of a manus (hand)." []
synonym: "digit of hand" EXACT []
synonym: "digit of manus" EXACT []
synonym: "digitus manus" EXACT []
synonym: "finger" EXACT []
synonym: "fore digit" EXACT []
synonym: "forelimb digit" EXACT []
synonym: "hand digit" EXACT []
synonym: "manual digit (phalangeal portion) plus soft tissue" EXACT []
is_a: UBERON:0002544 ! digit
intersection_of: UBERON:0002544 ! digit
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0012141 ! manual digitopodium region
relationship: part_of UBERON:5002389 ! manual digit plus metapodial segment

[Term]
id: UBERON:0002390
name: hematopoietic system
def: "Anatomical system that is involved in the production of hematopoietic cells." []
synonym: "Blutbildungssystem" RELATED []
synonym: "haematological system" EXACT []
synonym: "haematopoietic system" RELATED []
synonym: "haemopoietic system" EXACT []
synonym: "hematological system" RELATED []
synonym: "hematolymphoid system" RELATED []
synonym: "hemopoietic system" RELATED []
synonym: "organa haemopoietica" EXACT []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004120 ! mesoderm-derived structure
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: develops_from UBERON:0003061 ! blood island
relationship: part_of UBERON:0002193 ! hemolymphoid system

[Term]
id: UBERON:0002391
name: lymph
def: "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system[WP]." []
synonym: "lympha" RELATED []
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: develops_from UBERON:0000913 ! interstitial fluid

[Term]
id: UBERON:0002392
name: nasolacrimal duct
def: "the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity" []
synonym: "d. nasolacrimalis" RELATED []
synonym: "nasolacrimal duct - posterior naris" BROAD []
synonym: "tear duct" RELATED []
is_a: UBERON:0000058 ! duct
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0006266 ! nasolacrimal groove
relationship: has_part UBERON:0007602 ! stratified columnar epithelium
relationship: part_of UBERON:0001850 ! lacrimal drainage system

[Term]
id: UBERON:0002394
name: bile duct
def: "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." []
synonym: "bile tube" RELATED []
synonym: "biliary duct" RELATED []
synonym: "gall duct" RELATED []
synonym: "hepatic duct" RELATED []
is_a: UBERON:0003928 ! digestive system duct
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001173 ! biliary tree
relationship: develops_from UBERON:0008835 ! hepatic diverticulum
relationship: part_of UBERON:0001173 ! biliary tree

[Term]
id: UBERON:0002398
name: manus
def: "distal segment of the fore limb, including carpal region, metacarpal region and digits." []
synonym: "fore foot" NARROW []
synonym: "fore paw" NARROW []
synonym: "fore-paw" NARROW []
synonym: "forefeet" NARROW []
synonym: "forefoot" NARROW []
synonym: "forefoot of quadruped" NARROW []
synonym: "forelimb autopod" EXACT []
synonym: "forelimb autopodium" EXACT []
synonym: "forepaw" NARROW []
synonym: "hand" EXACT []
synonym: "hand region" EXACT []
synonym: "terminal segment of free upper limb" EXACT []
is_a: UBERON:0002470 ! autopod region
is_a: UBERON:0008785 ! upper limb segment
intersection_of: UBERON:0002470 ! autopod region
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: develops_from UBERON:0006875 ! handplate
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0002400
name: parietal pleura
def: "The outer serous membrane of the pulmonary pleural." []
synonym: "pleura parietalis" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0000977 ! pleura

[Term]
id: UBERON:0002401
name: visceral pleura
def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." []
synonym: "lung mesothelium" RELATED []
synonym: "lung pleura" RELATED []
synonym: "pleura pulmonalis" EXACT []
synonym: "pleura visceralis" EXACT []
synonym: "pleura visceralis (pulmonalis)" EXACT []
synonym: "pulmonary pleura" RELATED []
synonym: "pulmonary visceral pleura" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0022350 ! visceral serous membrane
relationship: part_of UBERON:0000977 ! pleura
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0002402
name: pleural cavity
def: "The fluid-filled cavity that lies between the visceral and parietal pleurae." []
synonym: "cavitas pleuralis" EXACT []
synonym: "cavitum pleuralae" RELATED []
synonym: "cavitum pleurale" RELATED []
is_a: UBERON:0035809 ! serous cavity
relationship: develops_from UBERON:0003887 ! intraembryonic coelom

[Term]
id: UBERON:0002405
name: immune system
def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system

[Term]
id: UBERON:0002406
name: pericardial sac
def: "a double-walled sac containing the heart and the roots of the great vessels." []
synonym: "pericardium" RELATED []
is_a: UBERON:0005181 ! thoracic segment organ
is_a: UBERON:0005906 ! serous sac
intersection_of: UBERON:0005906 ! serous sac
intersection_of: has_part UBERON:0001074 ! pericardial cavity
intersection_of: has_part UBERON:0002357 ! serous pericardium
relationship: has_part UBERON:0001074 ! pericardial cavity
relationship: has_part UBERON:0002357 ! serous pericardium
relationship: part_of UBERON:0001009 ! circulatory system
relationship: part_of UBERON:0002407 ! pericardium

[Term]
id: UBERON:0002407
name: pericardium
def: "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000481 ! multi-tissue structure
relationship: has_part UBERON:0002359 ! fibrous pericardium
relationship: has_part UBERON:0002406 ! pericardial sac
relationship: part_of UBERON:0015410 ! heart plus pericardium

[Term]
id: UBERON:0002408
name: parietal serous pericardium
def: "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." []
synonym: "lamina parietalis (pericardii serosum)" EXACT []
synonym: "lamina parietalis pericardii" EXACT []
synonym: "parietal layer of serous pericardium" EXACT []
synonym: "parietal pericardium" EXACT []
synonym: "pericardial sac" RELATED []
is_a: UBERON:0022351 ! parietal serous membrane
intersection_of: UBERON:0022351 ! parietal serous membrane
intersection_of: part_of UBERON:0002357 ! serous pericardium
relationship: part_of UBERON:0002357 ! serous pericardium

[Term]
id: UBERON:0002410
name: autonomic nervous system
def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." []
synonym: "ANS" RELATED []
synonym: "autonomic division of peripheral nervous system" EXACT []
synonym: "autonomic part of peripheral nervous system" EXACT []
synonym: "divisio autonomica systematis nervosi peripherici" EXACT []
synonym: "divisio autonomica systematis nervosi peripherici" RELATED []
synonym: "pars autonomica systematis nervosi peripherici" EXACT []
synonym: "peripheral autonomic nervous system" EXACT []
synonym: "visceral nervous system" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0002412
name: vertebra
def: "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." []
synonym: "vertebra bone" EXACT []
synonym: "vertebrae" EXACT []
is_a: UBERON:0002513 ! endochondral bone
is_a: UBERON:0008001 ! irregular bone
is_a: UBERON:0010913 ! vertebral element
relationship: develops_from UBERON:0011094 ! vertebra cartilage element
relationship: part_of UBERON:0001130 ! vertebral column

[Term]
id: UBERON:0002416
name: integumental system
def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." []
synonym: "body surface" RELATED []
synonym: "dermal system" RELATED []
synonym: "external covering of organism" RELATED []
synonym: "integumentary system" EXACT []
synonym: "integumentum commune" RELATED []
synonym: "organism surface" RELATED []
synonym: "surface" RELATED []
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0007376 ! outer epithelium

[Term]
id: UBERON:0002417
name: abdominal segment of trunk
def: "The abdominal segment of the torso." []
synonym: "abdomen/pelvis/perineum" RELATED []
synonym: "lower body" RELATED []
synonym: "lower trunk" RELATED []
synonym: "lumbar region" RELATED []
is_a: UBERON:0009569 ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis

[Term]
id: UBERON:0002418
name: cartilage tissue
def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." []
synonym: "cartilage" RELATED []
synonym: "cartilage tissue" EXACT []
synonym: "cartilages" RELATED []
synonym: "cartilaginous tissue" EXACT []
synonym: "chondrogenic tissue" EXACT []
synonym: "portion of cartilage tissue" RELATED []
is_a: UBERON:0004755 ! skeletal tissue
disjoint_from: UBERON:0002481 ! bone tissue
relationship: part_of UBERON:0002204 ! musculoskeletal system

[Term]
id: UBERON:0002419
name: skin gland
def: "A gland that is part of a skin of body [Automatically generated definition]." []
synonym: "glandulae cutis" EXACT []
synonym: "set of skin glands" RELATED []
synonym: "skin glands" RELATED []
synonym: "skin glands set" RELATED []
is_a: UBERON:0003297 ! gland of integumental system
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0006003 ! integumentary adnexa
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: UBERON:0002420
name: basal ganglion
def: "An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]." []
synonym: "basal ganglia" RELATED []
synonym: "basal ganglion of telencephalon" EXACT []
synonym: "basal nucleus" RELATED []
synonym: "nuclei basales" RELATED []
is_a: UBERON:0003528 ! brain gray matter
is_a: UBERON:0007245 ! nuclear complex of neuraxis
relationship: part_of UBERON:0010011 ! collection of basal ganglia

[Term]
id: UBERON:0002421
name: hippocampal formation
def: "Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment]." []
synonym: "archipallium" RELATED []
synonym: "formatio hippocampi" RELATED []
synonym: "hippocampus" NARROW []
synonym: "hippocampus (Crosby)" EXACT []
synonym: "major hippocampus" RELATED []
synonym: "primal cortex" RELATED []
synonym: "seahorse" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000203 ! pallium
relationship: part_of UBERON:0000956 ! cerebral cortex

[Term]
id: UBERON:0002422
name: fourth ventricle
def: "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." []
synonym: "4th ventricle" RELATED []
synonym: "fourth ventricle proper" RELATED []
synonym: "hindbrain ventricle" RELATED []
synonym: "IVth ventricle" RELATED []
synonym: "rhombencephalic ventricle" RELATED []
synonym: "rhombencephalic vesicle" NARROW []
synonym: "ventricle IV" EXACT []
synonym: "ventricle of hindbrain" RELATED []
synonym: "ventricle of rhombencephalon" RELATED []
synonym: "ventriculus quartus" RELATED []
is_a: UBERON:0004086 ! brain ventricle
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0004086 ! brain ventricle
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: develops_from UBERON:0013149 ! hindbrain vesicle
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0002423
name: hepatobiliary system
def: "The part of the digestive system that contains the liver and the biliary system" []
synonym: "hepaticobiliary system" EXACT []
synonym: "liver and biliary system" EXACT []
synonym: "liver/biliary system" RELATED []
is_a: UBERON:0011216 ! organ system subdivision
disjoint_from: UBERON:0004456 ! entire sense organ system
relationship: has_part UBERON:0002107 ! liver
relationship: has_part UBERON:0002294 ! biliary system
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0002424
name: oral epithelium
def: "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues" []
synonym: "epithelium of mucosa of mouth" EXACT []
synonym: "epithelium of oral mucosa" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003729 ! mouth mucosa
relationship: part_of UBERON:0003729 ! mouth mucosa

[Term]
id: UBERON:0002425
name: visceral serous pericardium
def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." []
synonym: "epicardium" RELATED []
synonym: "lamina visceralis pericardii serosi" EXACT []
synonym: "pericardium visceral mesothelium" RELATED []
synonym: "serous visceral pericardium" EXACT []
synonym: "visceral lamina of serous pericardium" EXACT []
synonym: "visceral layer of serous pericardium" EXACT []
synonym: "visceral pericardium" EXACT []
is_a: UBERON:0022350 ! visceral serous membrane
intersection_of: UBERON:0022350 ! visceral serous membrane
intersection_of: part_of UBERON:0002357 ! serous pericardium
relationship: has_part UBERON:0002348 ! epicardium
relationship: part_of UBERON:0002357 ! serous pericardium

[Term]
id: UBERON:0002426
name: chest muscle
def: "Any muscle organ that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region muscle organ" EXACT []
synonym: "anterolateral part of thorax muscle organ" EXACT []
synonym: "chest muscle organ" EXACT []
synonym: "front of thorax muscle organ" EXACT []
synonym: "muscle of thorax" EXACT []
synonym: "muscle organ of anterior thoracic region" EXACT []
synonym: "muscle organ of anterolateral part of thorax" EXACT []
synonym: "muscle organ of chest" EXACT []
synonym: "muscle organ of front of thorax" EXACT []
synonym: "musculus thoracicus" EXACT []
synonym: "thoracic muscle" EXACT []
is_a: UBERON:0003830 ! thoracic segment muscle
is_a: UBERON:0005175 ! chest organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0002427
name: arm skin
def: "A zone of skin that is part of an arm [Automatically generated definition]." []
synonym: "brachial region skin" EXACT []
synonym: "proximal segment of free upper limb skin" EXACT []
synonym: "skin of arm" EXACT []
synonym: "skin of brachial region" EXACT []
synonym: "skin of proximal segment of free upper limb" EXACT []
is_a: UBERON:0003531 ! forelimb skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0002428
name: limb bone
def: "A bone that is part of a limb [Automatically generated definition]." []
synonym: "bone of extremity" EXACT []
synonym: "bone of limb" EXACT []
synonym: "free limb bone" EXACT []
is_a: UBERON:0002513 ! endochondral bone
is_a: UBERON:0004375 ! bone of free limb or fin
is_a: UBERON:0015061 ! limb endochondral element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002101 ! limb
relationship: develops_from UBERON:0010881 ! limb cartilage element
relationship: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0004381 ! skeleton of limb

[Term]
id: UBERON:0002435
name: striatum
def: "A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO]." []
synonym: "caudate putamen" RELATED []
synonym: "corpus striatum" RELATED []
synonym: "corpus striatum (Zilles)" RELATED []
synonym: "dorsal striatum" RELATED []
synonym: "neostriatum" EXACT []
synonym: "neuraxis striatum" EXACT []
synonym: "striate nucleus" EXACT []
synonym: "striated nucleus" RELATED []
synonym: "striatum" EXACT []
synonym: "striatum of neuraxis" EXACT []
is_a: UBERON:0011300 ! gray matter of telencephalon
relationship: part_of UBERON:0000204 ! ventral part of telencephalon
relationship: part_of UBERON:0000369 ! corpus striatum
relationship: part_of UBERON:0002420 ! basal ganglion
relationship: part_of UBERON:0006098 ! basal nuclear complex

[Term]
id: UBERON:0002437
name: cerebral hemisphere white matter
def: "White matter that is part of a cerebral hemisphere." []
synonym: "cerebral hemisphere white matter" EXACT []
synonym: "cerebral white matter" EXACT []
synonym: "hemisphere white matter" RELATED []
synonym: "region of cerebral white matter" RELATED []
synonym: "substantia medullaris cerebri" RELATED []
synonym: "white matter structure of cerebral hemisphere" EXACT []
is_a: UBERON:0011299 ! white matter of telencephalon
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001869 ! cerebral hemisphere
relationship: part_of UBERON:0001869 ! cerebral hemisphere

[Term]
id: UBERON:0002443
name: choroidal blood vessel
def: "A blood vessel that is part of a choroid [Automatically generated definition]." []
synonym: "blood vessel of choroid" EXACT []
synonym: "blood vessel of choroid coat" EXACT []
synonym: "blood vessel of choroidea" EXACT []
synonym: "blood vessel of posterior uvea" EXACT []
synonym: "choroid blood vessel" EXACT []
synonym: "choroid blood vessels" EXACT []
synonym: "choroid blood vessels set" EXACT []
synonym: "choroid coat blood vessel" EXACT []
synonym: "choroidea blood vessel" EXACT []
synonym: "posterior uvea blood vessel" EXACT []
synonym: "set of choroid blood vessels" RELATED []
synonym: "vasa sanguinea choroideae" EXACT []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001776 ! optic choroid

[Term]
id: UBERON:0002450
name: decidua
def: "Uterine lining (endometrium) during a pregnancy, which forms the maternal part of the placenta. It is formed under the influence of progesterone and forms highly-characteristic cells." []
synonym: "decidous membrane" EXACT []
synonym: "decidua basalis" RELATED []
synonym: "endometrium" RELATED []
synonym: "extraembryonic part of placenta" RELATED []
synonym: "extraembryonic placenta" RELATED []
synonym: "maternal decidual layer" RELATED []
synonym: "maternal part of placenta" RELATED []
synonym: "maternal placenta" RELATED []
synonym: "placenta maternal decidual layer" RELATED []
synonym: "uterine decidua" RELATED []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
relationship: develops_from UBERON:0000459 ! uterine wall
relationship: part_of UBERON:0001987 ! placenta

[Term]
id: UBERON:0002451
name: endometrial gland
def: "The mucous secreting gland associated with the mucuous membrane lining the uterus." []
synonym: "endometrial gland" EXACT []
synonym: "endometrial mucuous gland" EXACT []
synonym: "endometrium gland" EXACT []
synonym: "glandulae uterinae" EXACT []
synonym: "glandulae uterinae" RELATED []
synonym: "uterine gland" EXACT []
is_a: UBERON:0000414 ! mucous gland
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005179 ! pelvic region element
is_a: UBERON:0005398 ! female reproductive gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0012276 ! endometrium glandular epithelium

[Term]
id: UBERON:0002456
name: internal thoracic artery
def: "In human anatomy, the internal thoracic artery (ITA), previously known as the internal mammary artery (a name still common among surgeons), is an artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted]." []
synonym: "arteria mammaria interna" RELATED []
synonym: "arteria thoracica interna" RELATED []
synonym: "internal mammary artery" EXACT []
synonym: "internal thoracic mammary artery" EXACT []
synonym: "mammary artery" RELATED []
is_a: UBERON:0004573 ! systemic artery
relationship: part_of UBERON:0001533 ! subclavian artery

[Term]
id: UBERON:0002457
name: intersomitic artery
def: "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" []
synonym: "intersegmental arteries" RELATED []
synonym: "intersegmental artery" EXACT []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0014907 ! intersomitic vessel

[Term]
id: UBERON:0002465
name: lymphoid system
def: "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." []
synonym: "lymphatic circulatory system" RELATED []
synonym: "lymphatic drainage system" RELATED []
synonym: "lymphatic system" NARROW []
synonym: "systema lymphoideum" RELATED []
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0002193 ! hemolymphoid system
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: UBERON:0002469
name: esophagus mucosa
def: "A mucosa that is part of a esophagus [Automatically generated definition]." []
synonym: "esophageal mucosa" EXACT []
synonym: "esophageal mucous membrane" EXACT []
synonym: "esophagus mucosa" EXACT []
synonym: "esophagus mucous membrane" EXACT []
synonym: "lamina muscularis mucosae oesophageae" EXACT []
synonym: "mucosa of esophagus" EXACT []
synonym: "mucosa of oesophagus" EXACT []
synonym: "mucous membrane of esophagus" EXACT []
synonym: "mucous membrane of oesophagus" EXACT []
synonym: "muscularis mucosae of oesophagus" RELATED []
synonym: "oesophageal mucosa" EXACT []
synonym: "oesophagus mucosa" EXACT []
synonym: "oesophagus mucous membrane" EXACT []
synonym: "tunica mucosa esophagi" EXACT []
synonym: "tunica mucosa oesophageae" EXACT []
synonym: "tunica mucosa oesophagi" EXACT []
synonym: "tunica mucosa oesophagi" RELATED []
is_a: UBERON:0000344 ! mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001096 ! wall of esophagus

[Term]
id: UBERON:0002470
name: autopod region
def: "Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot" []
synonym: "autopod" BROAD []
synonym: "autopodial element" RELATED []
synonym: "autopodial limb segment" EXACT []
synonym: "autopodial segment" EXACT []
synonym: "autopodium" EXACT []
synonym: "autopodium region" EXACT []
synonym: "distal free limb segment" EXACT []
synonym: "distal segment of free limb" EXACT []
synonym: "distal segment of limb" RELATED []
synonym: "manus/pes" RELATED []
synonym: "paw" RELATED []
synonym: "paw/hand/foot/hoof" RELATED []
synonym: "pod" RELATED []
is_a: UBERON:0002529 ! limb segment
relationship: develops_from UBERON:0010130 ! autopod plate

[Term]
id: UBERON:0002472
name: stylopod
def: "The proximal free limb segment. Includes as parts the stylopod skeleton." []
synonym: "propodium" EXACT []
synonym: "proximal free limb segment" EXACT []
synonym: "proximal part of limb" BROAD []
synonym: "proximal segment of free limb" RELATED []
synonym: "stylopodial limb segment" EXACT []
synonym: "stylopodium" EXACT []
is_a: UBERON:0002529 ! limb segment
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0002481
name: bone tissue
def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." []
synonym: "bone" RELATED []
synonym: "calcium tissue" EXACT []
synonym: "mineralized bone tissue" NARROW []
synonym: "osseous tissue" EXACT []
synonym: "osteogenic tissue" EXACT []
synonym: "portion of bone tissue" RELATED []
is_a: UBERON:0004755 ! skeletal tissue
disjoint_from: UBERON:0005090 ! muscle structure
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0002485
name: prostate duct
def: "The minute canals that pass the prostatic secretions to the urethra." []
synonym: "duct of prostate" EXACT []
synonym: "duct of prostate gland" EXACT []
synonym: "prostate duct" EXACT []
synonym: "prostate gland duct" EXACT []
synonym: "prostatic duct" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005904 ! duct of male reproductive system
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: develops_from UBERON:0003820 ! prostate bud
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0002495
name: long bone
def: "Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]." []
synonym: "os longum" RELATED []
is_a: UBERON:0001474 ! bone element
relationship: part_of UBERON:0002091 ! appendicular skeleton

[Term]
id: UBERON:0002499
name: cochlear labyrinth
def: "The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001849 ! membranous labyrinth

[Term]
id: UBERON:0002506
name: iris epithelium
def: "An epithelium that is part of a iris [Automatically generated definition]." []
synonym: "epithelial tissue of iris" EXACT []
synonym: "epithelium of iris" EXACT []
synonym: "epithelium pigmentosum (iris)" EXACT []
synonym: "epithelium pigmentosum iridis" EXACT []
synonym: "iris epithelial tissue" EXACT []
synonym: "iris epithelium" EXACT []
synonym: "iris pigmented epithelium" RELATED []
synonym: "pigmented epithelium of iris" EXACT []
is_a: UBERON:0000488 ! atypical epithelium
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0002507
name: abdominal lymph node
def: "A lymph node that is part of an abdomen [Automatically generated definition]." []
synonym: "abdomen lymph node" EXACT []
synonym: "lymph node of abdomen" EXACT []
synonym: "parietal abdominal lymph node" RELATED []
is_a: UBERON:0000029 ! lymph node
is_a: UBERON:0005172 ! abdomen element
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0002509
name: mesenteric lymph node
def: "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." []
synonym: "mesenteric node" EXACT []
synonym: "nodi lymphoidei mesenterici" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0015860 ! visceral abdominal lymph node
intersection_of: UBERON:0002507 ! abdominal lymph node
intersection_of: part_of UBERON:0002095 ! mesentery
relationship: part_of UBERON:0002095 ! mesentery

[Term]
id: UBERON:0002512
name: corpus luteum
def: "A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]." []
synonym: "corpora lutea" EXACT []
synonym: "corpus luteum of ovary" EXACT []
synonym: "luteal gland" RELATED []
synonym: "ovarian corpus luteum" EXACT []
is_a: UBERON:0002368 ! endocrine gland
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005398 ! female reproductive gland
relationship: develops_from UBERON:0001305 ! ovarian follicle
relationship: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0002513
name: endochondral bone
def: "Replacement bone that forms within cartilage." []
synonym: "cartilaginous bone" RELATED []
synonym: "endochondral bones" RELATED []
synonym: "ossified chondrogenic bone" EXACT []
is_a: UBERON:0001474 ! bone element
is_a: UBERON:0010363 ! endochondral element
intersection_of: UBERON:0001474 ! bone element
intersection_of: develops_from UBERON:0005863 ! cartilaginous condensation
relationship: develops_from UBERON:0005863 ! cartilaginous condensation
relationship: develops_from UBERON:0007844 ! cartilage element

[Term]
id: UBERON:0002515
name: periosteum
def: "the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" []
is_a: UBERON:0000158 ! membranous layer
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0002517
name: basicranium
def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." []
synonym: "base of cranium" EXACT []
synonym: "base of skull" EXACT []
synonym: "basis cranii" EXACT []
synonym: "cranial base" EXACT []
is_a: UBERON:0000075 ! subdivision of skeletal system
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001703 ! neurocranium
relationship: part_of UBERON:0002241 ! chondrocranium

[Term]
id: UBERON:0002518
name: otolith organ
def: "the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane)" []
synonym: "otolith organs" RELATED []
synonym: "saccule and utricle" RELATED []
synonym: "utricle and saccule" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0006585 ! vestibular organ
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001862 ! vestibular labyrinth
relationship: part_of UBERON:0004681 ! vestibular system

[Term]
id: UBERON:0002521
name: elastic tissue
def: "Connective tissue composed of elastic fibers." []
synonym: "elastic connective tissue" EXACT []
synonym: "elastic fiber" NARROW []
synonym: "textus connectivus elasticus" EXACT []
is_a: UBERON:0002384 ! connective tissue

[Term]
id: UBERON:0002523
name: tunica intima
def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." []
synonym: "Bichat's tunic" RELATED []
synonym: "intima" RELATED []
synonym: "tunica intima vasorum" RELATED []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004797 ! blood vessel layer

[Term]
id: UBERON:0002527
name: pancreatic lymph node
def: "A lymph node that is part of a pancreas [Automatically generated definition]." []
synonym: "aJCC level 19 node" RELATED []
synonym: "lymph node of pancreas" EXACT []
synonym: "pancreas lymph node" EXACT []
synonym: "pancreatic node" EXACT []
synonym: "pyloric lymph node" RELATED []
is_a: UBERON:0002507 ! abdominal lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0002529
name: limb segment
def: "A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles." []
synonym: "extremity part" RELATED []
synonym: "free limb segment" EXACT []
synonym: "limb region" RELATED []
synonym: "region of limb" RELATED []
synonym: "segment of limb" EXACT []
synonym: "subdivision of limb" EXACT []
is_a: UBERON:0010538 ! paired limb/fin segment
intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis
intersection_of: part_of UBERON:0002101 ! limb
disjoint_from: UBERON:0010912 ! subdivision of skeleton
relationship: has_part UBERON:0014892 ! skeletal muscle organ
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0002530
name: gland
def: "an organ that functions as a secretory or excretory organ" []
synonym: "Druese" RELATED []
synonym: "glandula" RELATED []
synonym: "glandular organ" EXACT []
is_a: UBERON:0000062 ! organ

[Term]
id: UBERON:0002532
name: epiblast (generic)
def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]" []
synonym: "blastocyst" RELATED []
synonym: "ectoblast" RELATED []
synonym: "epiblast" EXACT []
synonym: "epiblastus" RELATED []
synonym: "primitive ectoderm" RELATED []
is_a: UBERON:0002050 ! embryonic structure

[Term]
id: UBERON:0002539
name: pharyngeal arch
def: "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." []
synonym: "arcus pharyngei" RELATED []
synonym: "branchial arch" NARROW []
synonym: "pharyngeal arches" EXACT []
synonym: "visceral arch" RELATED []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010188 ! protuberance
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0008814 ! pharyngeal arch system
relationship: part_of UBERON:0008816 ! embryonic head

[Term]
id: UBERON:0002540
name: lateral line system
def: "A line of sensory organs and associated structures along the sides of fish and amphibia that detect vibrations and pressure changes." []
synonym: "lateral line organs" RELATED []
synonym: "lateral line stitches" RELATED []
synonym: "lateral-line organs" RELATED []
synonym: "ll" RELATED []
is_a: UBERON:0001032 ! sensory system
relationship: has_part UBERON:0010202 ! lateral line

[Term]
id: UBERON:0002544
name: digit
def: "A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans)." []
synonym: "acropodial unit" EXACT []
synonym: "digit (phalangeal portion) plus soft tissue" EXACT []
synonym: "limb digit" EXACT []
is_a: UBERON:0005881 ! autopodial extension
intersection_of: UBERON:0005881 ! autopodial extension
intersection_of: part_of UBERON:0012354 ! acropodium region
relationship: has_part UBERON:0015023 ! phalanx endochondral element
relationship: part_of UBERON:0012140 ! digitopodium region
relationship: part_of UBERON:0012354 ! acropodium region
relationship: part_of UBERON:5002544 ! digit plus metapodial segment

[Term]
id: UBERON:0002546
name: cranial placode
def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." []
synonym: "cranial placodes" RELATED []
synonym: "placode" BROAD []
is_a: UBERON:0005085 ! ectodermal placode
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0002553
name: anatomical cavity
def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." []
synonym: "cavity" BROAD []
is_a: UBERON:0000464 ! anatomical space

[Term]
id: UBERON:0002558
name: organ cavity
synonym: "cavity of organ" EXACT []
is_a: UBERON:0002553 ! anatomical cavity

[Term]
id: UBERON:0002600
name: limbic lobe
def: "Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem" []
synonym: "fornicate convolution" RELATED []
synonym: "fornicate gyrus" EXACT []
synonym: "fornicate lobe" RELATED []
synonym: "grande lobe limbique of broca" EXACT []
synonym: "gyrus fornicatus" RELATED []
synonym: "limbic lobe (carpenter)" EXACT []
synonym: "lobus limbicus" RELATED []
is_a: UBERON:0016526 ! lobe of cerebral hemisphere

[Term]
id: UBERON:0002616
name: regional part of brain
def: "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." []
synonym: "anatomical structure of brain" EXACT []
synonym: "biological structure of brain" EXACT []
synonym: "brain anatomical structure" EXACT []
synonym: "brain biological structure" EXACT []
synonym: "brain part" EXACT []
synonym: "neuraxis segment" EXACT []
synonym: "neuroanatomical region" EXACT []
synonym: "segment of brain" EXACT []
is_a: UBERON:0000073 ! regional part of nervous system
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0002743
name: basal forebrain
def: "A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert." []
synonym: "basal forebrain area" RELATED []
synonym: "pars basalis telencephali" RELATED []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0002749
name: regional part of cerebellar cortex
def: "A regional part of brain that is part of a cerebellar cortex [Automatically generated definition]." []
synonym: "cerebellar cortical segment" EXACT []
synonym: "segment of cerebellar cortex" EXACT []
is_a: UBERON:0002946 ! regional part of cerebellum
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0002129 ! cerebellar cortex
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: UBERON:0002827
name: vestibulocochlear ganglion
def: "the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" []
synonym: "acoustic ganglion" RELATED []
synonym: "acoustic ganglion VIII" EXACT []
synonym: "acoustico-vestibular VIII ganglion" EXACT []
synonym: "auditory ganglion" EXACT []
synonym: "auditory ganglion" RELATED []
synonym: "ganglion VIII" EXACT []
synonym: "gVIII" EXACT []
synonym: "nucleus nervi oculomotorii ventrolateralis" RELATED []
synonym: "nucleus nervi oculomotorii, pars ventralis" RELATED []
synonym: "SAG" BROAD []
synonym: "statoacoustic (VIII) ganglion" EXACT []
synonym: "statoacoustic ganglia" EXACT []
synonym: "statoacoustic ganglion" EXACT []
synonym: "statoacoustic VIII ganglion" RELATED []
synonym: "vestibulocochlear ganglia" RELATED []
synonym: "vestibulocochlear VIII ganglion" EXACT []
is_a: UBERON:0001714 ! cranial ganglion
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0003249 ! epithelium of otic placode
relationship: develops_from UBERON:0005565 ! facio-acoustic neural crest
relationship: develops_from UBERON:0012175 ! acoustico-facial VII-VIII ganglion complex
relationship: part_of UBERON:0002105 ! vestibulo-auditory system

[Term]
id: UBERON:0002926
name: gustatory epithelium
def: "A sensory epithelium that is part of a gustatory system." []
is_a: UBERON:0006934 ! sensory epithelium
intersection_of: UBERON:0006934 ! sensory epithelium
intersection_of: part_of UBERON:0001033 ! gustatory system
relationship: part_of UBERON:0000012 ! somatic nervous system
relationship: part_of UBERON:0001033 ! gustatory system

[Term]
id: UBERON:0002946
name: regional part of cerebellum
def: "A regional part of brain that is part of a cerebellum [Automatically generated definition]." []
synonym: "segment of cerebellum" EXACT []
synonym: "subdivision of cerebellum" RELATED []
is_a: UBERON:0002616 ! regional part of brain
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: UBERON:0003037
name: septum
def: "A wall, dividing a cavity or structure into smaller ones[WP]." []
synonym: "septa" EXACT []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0003050
name: olfactory placode
def: "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." []
synonym: "nasal I placode" RELATED []
synonym: "nasal placode" RELATED []
synonym: "olfactory placodes" EXACT []
synonym: "placoda nasalis" EXACT []
synonym: "placoda olfactoria" EXACT []
is_a: UBERON:0009955 ! neurogenic placode
relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0003051
name: ear vesicle
def: "The saccular invagination of ectoderm from which the vertebrate inner ear develops[BTO]. Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells[ZFA]. epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP]" []
synonym: "acoustic vesicle" RELATED []
synonym: "auditory vesicle" RELATED []
synonym: "otic vesicle" EXACT []
synonym: "otocyst" RELATED []
synonym: "OV" RELATED []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0006273 ! otic pit
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0003052
name: midbrain-hindbrain boundary
def: "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." []
synonym: "isthmic organizer territory" RELATED []
synonym: "isthmo-cerebellar region" RELATED []
synonym: "isthmus" RELATED []
synonym: "isthmus/MHB" RELATED []
synonym: "MHB" EXACT []
synonym: "mid-hindbrain boundary" EXACT []
synonym: "mid-hindbrain junction" EXACT []
synonym: "midbrain hindbrain boundary" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0007651 ! anatomical junction
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0003055
name: periderm
def: "A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis." []
synonym: "epidermis epithelial layer" RELATED []
synonym: "epidermis outer layer" RELATED []
synonym: "epitrichium" RELATED []
synonym: "EVL" RELATED []
synonym: "periderm" RELATED []
synonym: "skin periderm" EXACT []
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: develops_from UBERON:0007383 ! enveloping layer of ectoderm
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:0003056
name: pre-chordal neural plate
def: "The portion of neural plate anterior to the mid-hindbrain junction." []
synonym: "anterior neural plate" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0003075 ! neural plate

[Term]
id: UBERON:0003057
name: chordal neural plate
def: "The portion of neural plate posterior to the mid-hindbrain junction." []
synonym: "posterior neural plate" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0003075 ! neural plate

[Term]
id: UBERON:0003059
name: presomitic mesoderm
def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." []
synonym: "presumptive somite mesoderm" RELATED []
synonym: "PSM" RELATED []
synonym: "segmental plate" EXACT []
synonym: "somitogenic mesoderm" RELATED []
synonym: "somitomeric mesoderm" RELATED []
synonym: "unsegmented mesenchyme" RELATED []
synonym: "unsegmented paraxial mesoderm" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0003077 ! paraxial mesoderm

[Term]
id: UBERON:0003060
name: pronephric duct
def: "In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]." []
synonym: "archinephric duct" RELATED []
synonym: "ductus pronephricus" RELATED []
synonym: "pronephric ducts" RELATED []
is_a: UBERON:0009201 ! nephric duct
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: develops_from UBERON:0005721 ! pronephric mesoderm
relationship: part_of UBERON:0002120 ! pronephros

[Term]
id: UBERON:0003061
name: blood island
def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." []
synonym: "blood islands" EXACT []
synonym: "caudal hematopoietic tissue" RELATED []
synonym: "posterior blood island" RELATED []
synonym: "posterior ICM" RELATED []
synonym: "VBI" RELATED []
synonym: "ventral blood island" RELATED []
synonym: "ventral lateral plate mesoderm" BROAD []
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0003063
name: prechordal plate
def: "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" []
synonym: "head mesenchyme" BROAD []
synonym: "head mesoderm" BROAD []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0003068 ! axial mesoderm

[Term]
id: UBERON:0003064
name: intermediate mesoderm
def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." []
synonym: "IM" RELATED []
synonym: "intermediate mesenchyme" RELATED []
synonym: "intermediate plate" RELATED []
synonym: "intermediate plate mesoderm" RELATED []
synonym: "mesenchyma intermedium" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0005256 ! trunk mesenchyme

[Term]
id: UBERON:0003066
name: pharyngeal arch 2
def: "The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements." []
synonym: "2nd arch" RELATED []
synonym: "2nd pharyngeal arch" EXACT []
synonym: "2nd visceral arch" RELATED []
synonym: "arcus pharyngeus secundus" EXACT []
synonym: "branchial arch 2" EXACT []
synonym: "hyoid arch" EXACT []
synonym: "hyoid bars" RELATED []
synonym: "pharyngeal arch 2" EXACT []
synonym: "pharyngeal arches 2" RELATED []
synonym: "second branchial arch" EXACT []
synonym: "second pharyngeal arch" EXACT []
synonym: "second visceral arch" EXACT []
synonym: "visceral arch 2" EXACT []
is_a: UBERON:0002539 ! pharyngeal arch

[Term]
id: UBERON:0003067
name: dorsolateral placode
def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." []
synonym: "dorsolateral placodes" EXACT []
is_a: UBERON:0009955 ! neurogenic placode

[Term]
id: UBERON:0003068
name: axial mesoderm
def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." []
synonym: "chordamesoderm" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0003069
name: otic placode
def: "A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK]" []
synonym: "auditory placode" RELATED []
synonym: "ear placode" RELATED []
synonym: "ear/otic placode" RELATED []
synonym: "octaval placode" RELATED []
synonym: "octaval VIII placode" RELATED []
synonym: "placoda otica" EXACT []
is_a: UBERON:0003067 ! dorsolateral placode
relationship: part_of UBERON:0001690 ! ear

[Term]
id: UBERON:0003071
name: eye primordium
def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." []
synonym: "eye anlage" RELATED []
synonym: "eye field" RELATED []
synonym: "eye placode" EXACT []
synonym: "occular primordium" EXACT []
synonym: "ocular primordium" EXACT []
synonym: "optic field" RELATED []
synonym: "optic placode" EXACT []
synonym: "optic placode of camera-type eye" EXACT []
synonym: "optic placodes" RELATED []
synonym: "optic primordium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0003056 ! pre-chordal neural plate
relationship: part_of UBERON:0003056 ! pre-chordal neural plate

[Term]
id: UBERON:0003072
name: optic cup
def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." []
synonym: "eye cup" RELATED []
synonym: "eyecup" RELATED []
synonym: "ocular cup" RELATED []
synonym: "ophtalmic cup" RELATED []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0004128 ! optic vesicle
relationship: part_of UBERON:0010312 ! immature eye

[Term]
id: UBERON:0003073
name: lens placode
def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." []
synonym: "lens placodes" RELATED []
synonym: "placoda lentis" RELATED []
is_a: UBERON:0002546 ! cranial placode
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0010312 ! immature eye
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode
relationship: part_of UBERON:0010312 ! immature eye

[Term]
id: UBERON:0003074
name: mesonephric duct
def: "Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]." []
synonym: "archinephric duct" RELATED []
synonym: "ductus mesonephricus; ductus Wolffi" RELATED []
synonym: "Leydig's duct" RELATED []
synonym: "renal duct" RELATED []
synonym: "Wolffian duct" EXACT []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0009201 ! nephric duct
relationship: develops_from UBERON:0003060 ! pronephric duct
relationship: develops_from UBERON:0005792 ! nephric ridge
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0003075
name: neural plate
def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]" []
synonym: "lamina neuralis" RELATED []
synonym: "presumptive central nervous system" RELATED []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system

[Term]
id: UBERON:0003076
name: posterior neural tube
is_a: UBERON:0005423 ! developing anatomical structure
disjoint_from: UBERON:0003080 ! anterior neural tube
relationship: develops_from UBERON:0003057 ! chordal neural plate
relationship: part_of UBERON:0001049 ! neural tube

[Term]
id: UBERON:0003077
name: paraxial mesoderm
def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]" []
synonym: "mesoderma paraxiale" RELATED []
synonym: "paraxial mesenchyme" EXACT []
synonym: "somitic mesoderm" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0003080
name: anterior neural tube
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003056 ! pre-chordal neural plate
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001049 ! neural tube

[Term]
id: UBERON:0003081
name: lateral plate mesoderm
def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." []
synonym: "lateral mesoderm" EXACT []
synonym: "lateral plate" RELATED []
synonym: "lateral plate mesenchyme" RELATED []
synonym: "LPM" EXACT []
synonym: "mesoderma laminae lateralis" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007524 ! dense mesenchyme tissue
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0003082
name: myotome
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." []
synonym: "muscle plate" RELATED []
synonym: "myomere" RELATED []
synonym: "myomeres" EXACT []
synonym: "myotome region" RELATED []
synonym: "myotomes" RELATED []
synonym: "myotomus" RELATED []
is_a: UBERON:0017650 ! developing mesenchymal structure
relationship: develops_from UBERON:0002329 ! somite
relationship: develops_from UBERON:0004290 ! dermomyotome

[Term]
id: UBERON:0003083
name: trunk neural crest
def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." []
synonym: "TNC" EXACT []
synonym: "trunk crest" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002342 ! neural crest

[Term]
id: UBERON:0003084
name: heart primordium
def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." []
synonym: "cardiac field" RELATED []
synonym: "fused heart primordium" RELATED []
is_a: UBERON:0001048 ! primordium
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: develops_from UBERON:0004140 ! primary heart field
relationship: develops_from UBERON:0007005 ! cardiac mesoderm
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0003089
name: sclerotome
def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." []
synonym: "sclerotomes" EXACT []
synonym: "sclerotomus" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005856 ! developing mesenchymal condensation
is_a: UBERON:0007530 ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 ! somite

[Term]
id: UBERON:0003099
name: cranial neural crest
def: "neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." []
synonym: "cephalic neural crest" EXACT []
synonym: "CNC" EXACT []
synonym: "cranial NCC population" EXACT []
synonym: "crista neuralis cranialis" RELATED []
synonym: "head crest" RELATED []
synonym: "head NCC population" EXACT []
synonym: "head neural crest" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002342 ! neural crest

[Term]
id: UBERON:0003100
name: female organism
def: "Gonochoristic organism that can produce female gametes." []
synonym: "female" RELATED []
synonym: "female human body" NARROW []
is_a: UBERON:0000468 ! multicellular organism
disjoint_from: UBERON:0003101 ! male organism

[Term]
id: UBERON:0003101
name: male organism
def: "Gonochoristic organism that can produce male gametes." []
synonym: "male" RELATED []
synonym: "male human body" NARROW []
is_a: UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0003102
name: surface structure
def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." []
synonym: "anatomical surface feature" EXACT []
synonym: "surface feature" RELATED []
synonym: "surface region" RELATED []
synonym: "surface structures" RELATED []
is_a: UBERON:0000061 ! anatomical structure
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0003103
name: compound organ
def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." []
synonym: "organ" RELATED []
is_a: UBERON:0000062 ! organ

[Term]
id: UBERON:0003104
name: mesenchyme
def: "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]." []
synonym: "mesenchyma" RELATED []
synonym: "mesenchymal tissue" EXACT []
synonym: "mesenchyme tissue" EXACT []
synonym: "portion of mesenchymal tissue" EXACT []
synonym: "portion of mesenchyme tissue" EXACT []
is_a: UBERON:0000479 ! tissue

[Term]
id: UBERON:0003113
name: dermatocranium
def: "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." []
synonym: "dendrocranium" EXACT []
synonym: "dermal bone cranium" RELATED []
synonym: "dermal part of skull" RELATED []
synonym: "dermal skull bones" RELATED []
synonym: "dermal skull roof" NARROW []
synonym: "dermatocranial cover" NARROW []
synonym: "exocranium" EXACT []
synonym: "roof of skull" NARROW []
synonym: "roofing bones of the skull" RELATED []
synonym: "skull roof" NARROW []
is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system
relationship: part_of UBERON:0010323 ! cranial skeletal system
relationship: part_of UBERON:0010364 ! dermal skeleton

[Term]
id: UBERON:0003117
name: pharyngeal arch 6
def: "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles" []
synonym: "6th arch" EXACT []
synonym: "6th pharyngeal arch" RELATED []
synonym: "6th visceral arch" RELATED []
synonym: "branchial arch 4" RELATED []
synonym: "fourth branchial arch" RELATED []
synonym: "gill arch 4" EXACT []
synonym: "sixth branchial arch" EXACT []
synonym: "sixth pharyngeal arch" RELATED []
synonym: "sixth visceral arch" RELATED []
synonym: "visceral arch 6" EXACT []
is_a: UBERON:0002539 ! pharyngeal arch

[Term]
id: UBERON:0003118
name: pharyngeal arch artery 1
def: "The vessels formed within the first pair of branchial arches in embryogenesis" []
synonym: "1st aortic arch artery" RELATED []
synonym: "1st arch artery" EXACT []
synonym: "1st branchial arch artery" RELATED []
synonym: "1st pharyngeal arch artery" RELATED []
synonym: "AA1" EXACT []
synonym: "aortic arch 1" EXACT []
synonym: "first aortic arch" EXACT []
synonym: "first arch artery" RELATED []
synonym: "first branchial arch artery" EXACT []
synonym: "mandibular aortic arch" EXACT []
is_a: UBERON:0004363 ! pharyngeal arch artery
intersection_of: UBERON:0004363 ! pharyngeal arch artery
intersection_of: part_of UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0004362 ! pharyngeal arch 1

[Term]
id: UBERON:0003119
name: pharyngeal arch artery 2
def: "The vessels formed within the second pair of branchial arches in embryogenesis" []
synonym: "2nd aortic arch artery" RELATED []
synonym: "2nd arch artery" EXACT []
synonym: "2nd branchial arch artery" RELATED []
synonym: "2nd pharyngeal arch artery" RELATED []
synonym: "AA2" EXACT []
synonym: "aortic arch 2" EXACT []
synonym: "hyoid aortic arch" EXACT []
synonym: "second aortic arch" EXACT []
synonym: "second branchial arch artery" EXACT []
is_a: UBERON:0004363 ! pharyngeal arch artery
intersection_of: UBERON:0004363 ! pharyngeal arch artery
intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0003066 ! pharyngeal arch 2

[Term]
id: UBERON:0003123
name: pharyngeal arch artery 6
def: "The vessels formed within the sixth pair of branchial arches in embryogenesis" []
synonym: "6th aortic arch artery" RELATED []
synonym: "6th arch artery" EXACT []
synonym: "6th branchial arch artery" RELATED []
synonym: "6th pharyngeal arch artery" RELATED []
synonym: "AA6" EXACT []
synonym: "aortic arch 6" EXACT []
synonym: "pulmonary arch" RELATED []
synonym: "sixth aortic arch" EXACT []
synonym: "sixth branchial arch artery" EXACT []
is_a: UBERON:0004363 ! pharyngeal arch artery
intersection_of: UBERON:0004363 ! pharyngeal arch artery
intersection_of: part_of UBERON:0003117 ! pharyngeal arch 6
relationship: part_of UBERON:0003117 ! pharyngeal arch 6

[Term]
id: UBERON:0003124
name: chorion
def: "the outermost extraembryonic membrane" []
synonym: "chorion (vertebrates)" EXACT []
synonym: "chorion frondosum" RELATED []
synonym: "chorionic sac" RELATED []
synonym: "embryonic chorion" EXACT []
synonym: "fetal chorion" EXACT []
synonym: "uterine chorion" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0005971 ! amniotic fold
relationship: has_part UBERON:0003265 ! chorionic mesenchyme
relationship: has_part UBERON:0003374 ! chorionic ectoderm

[Term]
id: UBERON:0003126
name: trachea
def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." []
synonym: "cartilaginous trachea" EXACT []
synonym: "tracheal tubule" RELATED []
synonym: "vertebrate trachea" EXACT []
synonym: "windpipe" EXACT []
is_a: UBERON:0000117 ! respiratory tube
relationship: develops_from UBERON:0008947 ! respiratory primordium
relationship: part_of UBERON:0007196 ! tracheobronchial tree

[Term]
id: UBERON:0003127
name: open tracheal system trachea
def: "A respiratory airway that is part of an open tracheal system." []
synonym: "invertebrate trachea" EXACT []
synonym: "trachea" BROAD []
is_a: UBERON:0001005 ! respiratory airway
relationship: has_part UBERON:0003914 ! epithelial tube
relationship: part_of UBERON:0005155 ! open tracheal system

[Term]
id: UBERON:0003128
name: cranium
def: "Upper portion of the skull that excludes the mandible (when present in the organism)." []
synonym: "bones of cranium" EXACT []
synonym: "calvarium" RELATED []
synonym: "epicranial plate" RELATED []
synonym: "ossa cranii" EXACT []
synonym: "set of bones of cranium" EXACT []
synonym: "skeletal system of head" RELATED []
synonym: "skull minus mandible" EXACT []
synonym: "upper part of skull" EXACT []
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: part_of UBERON:0003129 ! skull

[Term]
id: UBERON:0003129
name: skull
def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." []
synonym: "cranial skeleton" RELATED []
synonym: "skeletal system of head" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000075 ! subdivision of skeletal system
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0003128 ! cranium
relationship: has_part UBERON:0003278 ! skeleton of lower jaw
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0010323 ! cranial skeletal system

[Term]
id: UBERON:0003133
name: reproductive organ
def: "An organ involved in reproduction" []
synonym: "genital organ" EXACT []
synonym: "genitalia" RELATED []
synonym: "reproductive system organ" EXACT []
synonym: "sex organ" EXACT []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0005156 ! reproductive structure
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0003134
name: female reproductive organ
def: "A female organ involved in reproduction" []
synonym: "female organism reproductive organ" EXACT []
synonym: "female organism reproductive structure" EXACT []
synonym: "female organism reproductive system organ" EXACT []
synonym: "female organism sex organ" EXACT []
synonym: "female reproductive gland/organ" EXACT []
synonym: "female reproductive system organ" EXACT []
synonym: "female sex organ" EXACT []
synonym: "reproductive organ of female organism" EXACT []
synonym: "reproductive structure of female organism" EXACT []
synonym: "reproductive system organ of female organism" EXACT []
synonym: "sex organ of female organism" EXACT []
is_a: UBERON:0003133 ! reproductive organ
intersection_of: UBERON:0003133 ! reproductive organ
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0003100 ! female organism

[Term]
id: UBERON:0003135
name: male reproductive organ
def: "A male organ involved in reproduction" []
synonym: "male organism reproductive organ" EXACT []
synonym: "male organism reproductive structure" EXACT []
synonym: "male organism reproductive system organ" EXACT []
synonym: "male organism sex organ" EXACT []
synonym: "male reproductive gland/organ" EXACT []
synonym: "male reproductive system organ" EXACT []
synonym: "male sex organ" EXACT []
synonym: "reproductive organ of male organism" EXACT []
synonym: "reproductive structure of male organism" EXACT []
synonym: "reproductive system organ of male organism" EXACT []
synonym: "sex organ of male organism" EXACT []
is_a: UBERON:0003133 ! reproductive organ
intersection_of: UBERON:0003133 ! reproductive organ
intersection_of: part_of UBERON:0003101 ! male organism
relationship: part_of UBERON:0000079 ! male reproductive system
relationship: part_of UBERON:0003101 ! male organism

[Term]
id: UBERON:0003210
name: blood-cerebrospinal fluid barrier
def: "barrier in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood[MP]." []
synonym: "blood-CSF barrier" EXACT []
is_a: UBERON:0000119 ! cell layer
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001886 ! choroid plexus

[Term]
id: UBERON:0003214
name: mammary gland alveolus
def: "A sac-like structure that is found in the mature gland[GO]." []
synonym: "alveolus of lactiferous gland" EXACT []
synonym: "alveolus of lobe of breast" EXACT []
synonym: "alveolus of lobe of mammary gland" EXACT []
synonym: "alveolus of mammary gland" EXACT []
synonym: "lactiferous alveolus" EXACT []
synonym: "lactiferous gland alveolus" EXACT []
synonym: "lobe of breast alveolus" EXACT []
synonym: "lobe of mammary gland alveolus" EXACT []
synonym: "mammary alveoli" RELATED []
synonym: "mammary alveolus" EXACT []
is_a: UBERON:0003215 ! alveolus
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003215 ! alveolus
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001912 ! lobule of mammary gland

[Term]
id: UBERON:0003215
name: alveolus
def: "organ part that has the form of a hollow cavity[WP]." []
is_a: UBERON:0000064 ! organ part

[Term]
id: UBERON:0003218
name: ovary septum
def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." []
is_a: UBERON:0003037 ! septum
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003037 ! septum
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0003220
name: metanephric mesenchyme
def: "one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]" []
synonym: "metanephric blastema" EXACT []
synonym: "metanephric mesoderm" EXACT []
synonym: "metanephrogenic mesenchyme" EXACT []
synonym: "metanephros associated mesenchyme" EXACT []
is_a: UBERON:0003918 ! kidney mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0003074 ! mesonephric duct
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0003221
name: phalanx
def: "Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits." []
synonym: "digit long bone" EXACT []
synonym: "long bone of digit" EXACT []
synonym: "phalange" EXACT []
synonym: "phalanges" EXACT []
synonym: "phalanx bone" EXACT []
is_a: UBERON:0003606 ! limb long bone
is_a: UBERON:0012357 ! digitopodium bone
is_a: UBERON:0015023 ! phalanx endochondral element
relationship: develops_from UBERON:0010701 ! phalanx cartilage element
relationship: part_of UBERON:5102544 ! individual digit of digitopodial skeleton

[Term]
id: UBERON:0003231
name: epithelium of hip
def: "An epithelium that is part of a hip [Automatically generated definition]." []
synonym: "epithelial tissue of hip" EXACT []
synonym: "epithelial tissue of hip region" EXACT []
synonym: "epithelial tissue of regio coxae" EXACT []
synonym: "epithelium of hip region" EXACT []
synonym: "epithelium of regio coxae" EXACT []
synonym: "hip epithelial tissue" EXACT []
synonym: "hip epithelium" EXACT []
synonym: "hip region epithelial tissue" EXACT []
synonym: "hip region epithelium" EXACT []
synonym: "regio coxae epithelial tissue" EXACT []
synonym: "regio coxae epithelium" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001464 ! hip
relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm
relationship: part_of UBERON:0001464 ! hip

[Term]
id: UBERON:0003232
name: epithelium of knee
def: "An epithelium that is part of a knee [Automatically generated definition]." []
synonym: "epithelial tissue of knee" EXACT []
synonym: "knee epithelial tissue" EXACT []
synonym: "knee epithelium" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001465 ! knee
relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm
relationship: part_of UBERON:0001465 ! knee

[Term]
id: UBERON:0003233
name: epithelium of shoulder
def: "An epithelium that is part of a shoulder [Automatically generated definition]." []
synonym: "epithelial tissue of shoulder" EXACT []
synonym: "shoulder epithelial tissue" EXACT []
synonym: "shoulder epithelium" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0003236
name: epithelium of lower jaw
def: "An epithelium that is part of a lower jaw [Automatically generated definition]." []
synonym: "epithelial tissue of lower jaw" EXACT []
synonym: "epithelial tissue of ventral mandibular arch" EXACT []
synonym: "epithelium of ventral mandibular arch" EXACT []
synonym: "lower jaw epithelial tissue" EXACT []
synonym: "lower jaw epithelium" EXACT []
synonym: "ventral mandibular arch epithelial tissue" EXACT []
synonym: "ventral mandibular arch epithelium" EXACT []
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: part_of UBERON:0001710 ! lower jaw region

[Term]
id: UBERON:0003241
name: epithelium of utricle
def: "An epithelium that is part of a utricle of membranous labyrinth [Automatically generated definition]." []
synonym: "epithelial tissue of membranous labyrinth utricle" EXACT []
synonym: "epithelial tissue of utricle" EXACT []
synonym: "epithelial tissue of utricle of membranous labyrinth" EXACT []
synonym: "epithelial tissue of utriculus (labyrinthus vestibularis)" EXACT []
synonym: "epithelium of macula of utricle of membranous labyrinth" NARROW []
synonym: "epithelium of membranous labyrinth utricle" EXACT []
synonym: "epithelium of utricle of membranous labyrinth" EXACT []
synonym: "epithelium of utriculus (labyrinthus vestibularis)" EXACT []
synonym: "membranous labyrinth utricle epithelial tissue" EXACT []
synonym: "membranous labyrinth utricle epithelium" EXACT []
synonym: "utricle epithelial tissue" EXACT []
synonym: "utricle epithelium" EXACT []
synonym: "utricle of membranous labyrinth epithelial tissue" EXACT []
synonym: "utricle of membranous labyrinth epithelium" EXACT []
synonym: "utriculus (labyrinthus vestibularis) epithelial tissue" EXACT []
synonym: "utriculus (labyrinthus vestibularis) epithelium" EXACT []
is_a: UBERON:0006932 ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth
relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth
relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth

[Term]
id: UBERON:0003242
name: epithelium of saccule
def: "An epithelium that is part of a saccule of membranous labyrinth [Automatically generated definition]." []
synonym: "epithelial tissue of membranous labyrinth saccule" EXACT []
synonym: "epithelial tissue of saccule" EXACT []
synonym: "epithelial tissue of saccule of membranous labyrinth" EXACT []
synonym: "epithelial tissue of sacculus (labyrinthus vestibularis)" EXACT []
synonym: "epithelium of macula of saccule of membranous labyrinth" RELATED []
synonym: "epithelium of membranous labyrinth saccule" EXACT []
synonym: "epithelium of saccule of membranous labyrinth" EXACT []
synonym: "epithelium of sacculus (labyrinthus vestibularis)" EXACT []
synonym: "membranous labyrinth saccule epithelial tissue" EXACT []
synonym: "membranous labyrinth saccule epithelium" EXACT []
synonym: "saccule epithelial tissue" EXACT []
synonym: "saccule epithelium" EXACT []
synonym: "saccule of membranous labyrinth epithelial tissue" EXACT []
synonym: "saccule of membranous labyrinth epithelium" EXACT []
synonym: "sacculus (labyrinthus vestibularis) epithelial tissue" EXACT []
synonym: "sacculus (labyrinthus vestibularis) epithelium" EXACT []
is_a: UBERON:0006932 ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001854 ! saccule of membranous labyrinth
relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth

[Term]
id: UBERON:0003243
name: epithelium of cochlear duct
def: "An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition]." []
synonym: "cochlear duct epithelial tissue" EXACT []
synonym: "cochlear duct epithelium" EXACT []
synonym: "cochlear duct of membranous labyrinth epithelial tissue" EXACT []
synonym: "cochlear duct of membranous labyrinth epithelium" EXACT []
synonym: "epithelial tissue of cochlear duct" EXACT []
synonym: "epithelial tissue of cochlear duct of membranous labyrinth" EXACT []
synonym: "epithelial tissue of Reissner's canal" EXACT []
synonym: "epithelium of cochlear duct of membranous labyrinth" EXACT []
synonym: "epithelium of Reissner's canal" EXACT []
synonym: "Reissner's canal epithelial tissue" EXACT []
synonym: "Reissner's canal epithelium" EXACT []
is_a: UBERON:0006937 ! inner ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth
relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth

[Term]
id: UBERON:0003244
name: epithelium of mammary gland
def: "the epithelial layer of the luminal surfaces of the mammary gland" []
synonym: "epithelium of lactiferous gland" EXACT []
synonym: "lactiferous gland epithelium" EXACT []
synonym: "mammary epithelium" EXACT []
synonym: "mammary gland epithelial tissue" EXACT []
synonym: "mammary gland epithelium" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0003248
name: epithelium of footplate
def: "An epithelium that is part of a footplate." []
synonym: "foot plate epithelium" EXACT []
synonym: "footplate epithelium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0006871 ! footplate
relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm
relationship: part_of UBERON:0006871 ! footplate

[Term]
id: UBERON:0003249
name: epithelium of otic placode
def: "An epithelium that is part of a otic placode [Automatically generated definition]." []
synonym: "epithelial tissue of otic placode" EXACT []
synonym: "otic epithelium" EXACT []
synonym: "otic placode epithelial tissue" EXACT []
synonym: "otic placode epithelium" EXACT []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0015807 ! ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003069 ! otic placode
relationship: part_of UBERON:0003069 ! otic placode

[Term]
id: UBERON:0003254
name: amniotic ectoderm
synonym: "amnion ectoderm" EXACT []
synonym: "amnion epithelium" RELATED []
synonym: "amnionic ectoderm" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010303 ! extraembryonic epithelium
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0002532 ! epiblast (generic)
relationship: part_of UBERON:0000305 ! amnion

[Term]
id: UBERON:0003257
name: yolk sac endoderm
def: "An extraembryonic structure that develops_from a endoderm and is part of a yolk sac." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000478 ! extraembryonic structure
intersection_of: UBERON:0000478 ! extraembryonic structure
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001040 ! yolk sac
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001040 ! yolk sac

[Term]
id: UBERON:0003258
name: endoderm of foregut
def: "An endoderm that is part of a foregut [Automatically generated definition]." []
synonym: "foregut endoderm" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0015833 ! foregut epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001041 ! foregut
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001041 ! foregut

[Term]
id: UBERON:0003259
name: endoderm of midgut
def: "An endoderm that is part of a midgut [Automatically generated definition]." []
synonym: "midgut endoderm" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0003352 ! epithelium of midgut
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001045 ! midgut
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001045 ! midgut

[Term]
id: UBERON:0003260
name: endoderm of hindgut
def: "An endoderm that is part of a hindgut [Automatically generated definition]." []
synonym: "hindgut endoderm" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0003353 ! epithelium of hindgut
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001046 ! hindgut
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001046 ! hindgut

[Term]
id: UBERON:0003262
name: amniotic mesoderm
def: "A mesenchyme that is part of a amnion." []
synonym: "amnion mesenchyme" EXACT []
synonym: "amnion mesoderm" EXACT []
synonym: "amnionic mesenchyme" RELATED []
synonym: "amnionic mesoderm" RELATED []
synonym: "mesenchyme of amnion" EXACT []
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000305 ! amnion
relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm
relationship: part_of UBERON:0000305 ! amnion

[Term]
id: UBERON:0003264
name: mesoderm of yolk sac
def: "A mesoderm that is part of a yolk sac [Automatically generated definition]." []
synonym: "yolk sac mesoderm" EXACT []
is_a: UBERON:0000926 ! mesoderm
is_a: UBERON:0003257 ! yolk sac endoderm
is_a: UBERON:0005292 ! extraembryonic tissue
intersection_of: UBERON:0000926 ! mesoderm
intersection_of: part_of UBERON:0001040 ! yolk sac
relationship: part_of UBERON:0001040 ! yolk sac

[Term]
id: UBERON:0003265
name: chorionic mesenchyme
def: "A mesenchyme that is part of a chorion." []
synonym: "chorion mesenchyme" EXACT []
synonym: "chorion mesoderm" EXACT []
synonym: "chorionic mesenchyme" EXACT []
synonym: "mesenchyme of chorion" EXACT []
synonym: "mesenchyme of chorion (vertebrates)" EXACT []
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003124 ! chorion
relationship: develops_from UBERON:0004871 ! somatic layer of lateral plate mesoderm
relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm
relationship: part_of UBERON:0003124 ! chorion

[Term]
id: UBERON:0003268
name: tooth of lower jaw
def: "A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary)." []
synonym: "calcareous tooth of lower jaw" EXACT []
synonym: "lower jaw calcareous tooth" EXACT []
synonym: "lower jaw dentine containing tooth" EXACT []
synonym: "lower jaw tooth" EXACT []
synonym: "lower jaw vertebrate tooth" EXACT []
synonym: "mandibular tooth" NARROW []
is_a: UBERON:0001091 ! calcareous tooth
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0001091 ! calcareous tooth
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: part_of UBERON:0001710 ! lower jaw region
relationship: part_of UBERON:0009679 ! set of lower jaw teeth

[Term]
id: UBERON:0003269
name: skeletal muscle tissue of eye
def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." []
synonym: "eye skeletal muscle" EXACT []
synonym: "eye skeletal muscle group" RELATED []
synonym: "eye skeletal muscle tissue" EXACT []
synonym: "skeletal muscle tissue of eye" EXACT []
is_a: UBERON:0001134 ! skeletal muscle tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0003273
name: obsolete skeletal muscle tissue of tongue
is_obsolete: true

[Term]
id: UBERON:0003278
name: skeleton of lower jaw
def: "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." []
synonym: "lower jaw" BROAD []
synonym: "lower jaw skeleton" EXACT []
synonym: "mandible" BROAD []
synonym: "mandibles" RELATED []
synonym: "mandibular series" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0001708 ! jaw skeleton
relationship: part_of UBERON:0001710 ! lower jaw region

[Term]
id: UBERON:0003279
name: endothelium of trachea
def: "An endothelium that is part of a trachea." []
synonym: "endothelium of windpipe" EXACT []
synonym: "trachea endothelium" EXACT []
synonym: "windpipe endothelium" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001901 ! epithelium of trachea
is_a: UBERON:0001986 ! endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003281
name: mesentery of stomach
def: "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." []
synonym: "mesentery of ventriculus" EXACT []
synonym: "mesogaster" EXACT []
synonym: "mesogastium" EXACT []
synonym: "mesogastrium" EXACT []
synonym: "stomach mesentery" EXACT []
synonym: "ventriculus mesentery" EXACT []
is_a: UBERON:0004854 ! gastrointestinal system mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: UBERON:0003282
name: mesentery of heart
def: "A mesentery that surrounds the heart." []
synonym: "cardiac mesentery" RELATED []
synonym: "heart mesentery" EXACT []
synonym: "mesocardium" RELATED []
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0003283
name: mesentery of oesophagus
def: "A mesentery that is part of a esophagus [Automatically generated definition]." []
synonym: "esophagus mesentery" EXACT []
synonym: "gullet mesentery" EXACT []
synonym: "mesentery of esophagus" EXACT []
synonym: "mesentery of gullet" EXACT []
synonym: "meso-esophagus" EXACT []
synonym: "oesophagus mesentery" EXACT []
is_a: UBERON:0001975 ! serosa of esophagus
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0003284
name: mesentery of midgut
def: "A mesentery that is part of a midgut [Automatically generated definition]." []
synonym: "midgut mesentery" EXACT []
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001045 ! midgut
relationship: part_of UBERON:0001045 ! midgut

[Term]
id: UBERON:0003288
name: meninx of midbrain
def: "A meninx that is part of a midbrain [Automatically generated definition]." []
synonym: "meninges of midbrain" EXACT []
synonym: "mesencephalon meninges" RELATED []
synonym: "midbrain meninges" EXACT []
synonym: "midbrain meninx" EXACT []
is_a: UBERON:0003547 ! brain meninx
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain

[Term]
id: UBERON:0003289
name: meninx of telencephalon
def: "A meninx that is part of a telencephalon [Automatically generated definition]." []
synonym: "meninges of telencephalon" EXACT []
synonym: "telencephalon meninges" EXACT []
synonym: "telencephalon meninx" EXACT []
is_a: UBERON:0003548 ! forebrain meninges
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0003290
name: meninx of diencephalon
def: "A meninx that is part of a diencephalon [Automatically generated definition]." []
synonym: "between brain meninges" EXACT []
synonym: "between brain meninx" EXACT []
synonym: "diencephalon meninges" EXACT []
synonym: "diencephalon meninx" EXACT []
synonym: "interbrain meninges" EXACT []
synonym: "interbrain meninx" EXACT []
synonym: "mature diencephalon meninges" EXACT []
synonym: "mature diencephalon meninx" EXACT []
synonym: "meninges of between brain" EXACT []
synonym: "meninges of diencephalon" EXACT []
synonym: "meninges of interbrain" EXACT []
synonym: "meninges of mature diencephalon" EXACT []
synonym: "meninx of between brain" EXACT []
synonym: "meninx of interbrain" EXACT []
synonym: "meninx of mature diencephalon" EXACT []
is_a: UBERON:0003548 ! forebrain meninges
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0003291
name: meninx of hindbrain
def: "A meninx that is part of a hindbrain [Automatically generated definition]." []
synonym: "hindbrain meninges" EXACT []
synonym: "hindbrain meninx" EXACT []
synonym: "meninges of hindbrain" EXACT []
synonym: "rhomencephalon meninges" RELATED []
is_a: UBERON:0003547 ! brain meninx
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0003292
name: meninx of spinal cord
def: "A meninx that is part of a spinal cord [Automatically generated definition]." []
synonym: "menines of spinal cord" EXACT []
synonym: "meninges of spinal cord" EXACT []
synonym: "spinal cord meninges" EXACT []
synonym: "spinal cord meninx" EXACT []
synonym: "spinal meninges" EXACT []
synonym: "spinal meninx" EXACT []
is_a: UBERON:0002360 ! meninx
is_a: UBERON:0005174 ! dorsal region element
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0003294
name: gland of foregut
def: "A gland that is part of a foregut [Automatically generated definition]." []
synonym: "foregut gland" EXACT []
is_a: UBERON:0003408 ! gland of gut
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001041 ! foregut
relationship: part_of UBERON:0001041 ! foregut

[Term]
id: UBERON:0003295
name: pharyngeal gland
def: "Racemose mucous glands beneath the mucous membrane of the pharynx." []
synonym: "glandulae pharyngeae" RELATED []
synonym: "pharynx gland" EXACT []
is_a: UBERON:0003408 ! gland of gut
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0003296
name: gland of diencephalon
def: "Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis." []
synonym: "diencephalon gland" EXACT []
synonym: "interbrain gland" EXACT []
is_a: UBERON:0002530 ! gland
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0003297
name: gland of integumental system
def: "A gland that is part of a integumental system [Automatically generated definition]." []
synonym: "integumental gland" EXACT []
synonym: "integumental system gland" EXACT []
synonym: "integumentary gland" EXACT []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0002416 ! integumental system
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0003304
name: mesoderm blood island
def: "A blood island that is part of a mesoderm." []
synonym: "mesenchyme blood island" RELATED []
synonym: "mesoderm blood islands" EXACT []
is_a: UBERON:0003061 ! blood island
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007503 ! epithelial vesicle
is_a: UBERON:0012275 ! meso-epithelium
is_a: UBERON:0012429 ! hemopoietic tissue
intersection_of: UBERON:0003061 ! blood island
intersection_of: part_of UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0000926 ! mesoderm
relationship: part_of UBERON:0007798 ! vascular system

[Term]
id: UBERON:0003312
name: mesenchyme of testis
def: "Mesenchyme that is part of a developing testis [Automatically generated definition]." []
synonym: "testis mesenchyme" EXACT []
is_a: UBERON:0003855 ! gonad mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000473 ! testis
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0003314
name: eye mesenchyme
def: "Mesenchyme that is part of a developing camera-type eye." []
synonym: "mesenchyme of eye" EXACT []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
is_a: UBERON:0009891 ! facial mesenchyme
is_a: UBERON:0010312 ! immature eye
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: develops_from UBERON:0009920 ! optic neural crest
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0003315
name: mesenchyme of ovary
def: "Mesenchyme that is part of a developing ovary [Automatically generated definition]." []
synonym: "female reproductive system gonad mesenchyme" EXACT []
synonym: "female reproductive system gonada mesenchyme" EXACT []
synonym: "gonad of female reproductive system mesenchyme" EXACT []
synonym: "gonada of female reproductive system mesenchyme" EXACT []
synonym: "mesenchyme of female reproductive system gonad" EXACT []
synonym: "mesenchyme of female reproductive system gonada" EXACT []
synonym: "mesenchyme of gonad of female reproductive system" EXACT []
synonym: "mesenchyme of gonada of female reproductive system" EXACT []
synonym: "ovary mesenchyme" EXACT []
is_a: UBERON:0003855 ! gonad mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0003316
name: mesenchyme of yolk sac
def: "Mesenchyme that is part of a yolk sac [Automatically generated definition]." []
synonym: "yolk sac mesenchyme" EXACT []
is_a: UBERON:0003257 ! yolk sac endoderm
is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001040 ! yolk sac
relationship: part_of UBERON:0001040 ! yolk sac

[Term]
id: UBERON:0003320
name: mesenchyme of hip
def: "Mesenchyme that is part of a developing hip [Automatically generated definition]." []
synonym: "hip mesenchyme" EXACT []
synonym: "hip region mesenchyme" EXACT []
synonym: "mesenchyme of hip region" EXACT []
synonym: "mesenchyme of regio coxae" EXACT []
synonym: "regio coxae mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001464 ! hip
relationship: part_of UBERON:0001464 ! hip

[Term]
id: UBERON:0003321
name: mesenchyme of knee
def: "Mesenchyme that is part of a developing knee [Automatically generated definition]." []
synonym: "knee mesenchyme" EXACT []
is_a: UBERON:0003860 ! hindlimb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001465 ! knee
relationship: part_of UBERON:0001465 ! knee

[Term]
id: UBERON:0003322
name: mesenchyme of shoulder
def: "Mesenchyme that is part of a developing shoulder [Automatically generated definition]." []
synonym: "shoulder mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0003324
name: mesenchyme of lower jaw
def: "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." []
synonym: "lower jaw mesenchyme" EXACT []
synonym: "mesenchyme of ventral mandibular arch" EXACT []
synonym: "ventral mandibular arch mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: develops_from UBERON:0006905 ! mandibular process mesenchyme
relationship: part_of UBERON:0001710 ! lower jaw region

[Term]
id: UBERON:0003325
name: mesenchyme of pinna
def: "Mesenchyme that is part of a developing pinna [Automatically generated definition]." []
synonym: "auricle mesenchyme" EXACT []
synonym: "auricle of ear mesenchyme" EXACT []
synonym: "auricle of external ear mesenchyme" EXACT []
synonym: "auricula (auris externa) mesenchyme" EXACT []
synonym: "auricula mesenchyme" EXACT []
synonym: "mesenchyme of auricle" EXACT []
synonym: "mesenchyme of auricle of ear" EXACT []
synonym: "mesenchyme of auricle of external ear" EXACT []
synonym: "mesenchyme of auricula" EXACT []
synonym: "mesenchyme of auricula (auris externa)" EXACT []
synonym: "mesenchyme of pinna of ear" EXACT []
synonym: "pinna mesenchyme" EXACT []
synonym: "pinna of ear mesenchyme" EXACT []
is_a: UBERON:0005253 ! head mesenchyme
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001757 ! pinna
relationship: part_of UBERON:0001757 ! pinna

[Term]
id: UBERON:0003326
name: mesenchyme of mammary gland
def: "Mesenchyme that is part of a developing mammary gland." []
synonym: "lactiferous gland mesenchyme" EXACT []
synonym: "lobe of breast mesenchyme" EXACT []
synonym: "lobe of mammary gland mesenchyme" EXACT []
synonym: "mammary gland mesenchyme" EXACT []
synonym: "mammary mesenchyme" EXACT []
synonym: "mesenchyme of lactiferous gland" EXACT []
synonym: "mesenchyme of lobe of breast" EXACT []
synonym: "mesenchyme of lobe of mammary gland" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0003328
name: mesenchyme of footplate
def: "Mesenchyme that is part of a footplate." []
synonym: "foot plate mesenchyme" EXACT []
is_a: UBERON:0010377 ! mesenchyme from somatopleure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0006871 ! footplate
relationship: develops_from UBERON:0003412 ! pelvic appendage bud mesenchyme
relationship: part_of UBERON:0006871 ! footplate

[Term]
id: UBERON:0003329
name: submucosa of anal canal
def: "A submucosa that is part of an anal canal [Automatically generated definition]." []
synonym: "anal canal submucosa" EXACT []
synonym: "anal canal viewed anatomically submucosa" EXACT []
synonym: "anal region submucosa" EXACT []
synonym: "anatomical anal canal submucosa" EXACT []
synonym: "submucosa of anal canal viewed anatomically" EXACT []
synonym: "submucosa of anal region" EXACT []
synonym: "submucosa of anatomical anal canal" EXACT []
is_a: UBERON:0001208 ! submucosa of large intestine
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0003330
name: submucosa of rectum
def: "The submucous layer of the wall of the rectum." []
synonym: "rectal submucosa" EXACT []
synonym: "rectum submucosa" EXACT []
synonym: "tela submucosa recti" EXACT []
is_a: UBERON:0001208 ! submucosa of large intestine
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0003331
name: submucosa of colon
def: "A submucosa that is part of a colon [Automatically generated definition]." []
synonym: "colon submucosa" EXACT []
synonym: "colonic submucosa" EXACT []
synonym: "large bowel submucosa" EXACT []
synonym: "submucosa of large bowel" EXACT []
is_a: UBERON:0001208 ! submucosa of large intestine
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0003332
name: submucosa of duodenum
def: "A submucosa that is part of a duodenum [Automatically generated definition]." []
synonym: "doudenal submucosa" EXACT []
synonym: "duodenal submucosa" EXACT []
synonym: "duodenum submucosa" EXACT []
is_a: UBERON:0001205 ! submucosa of small intestine
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0003333
name: submucosa of jejunum
def: "A submucosa that is part of a jejunum [Automatically generated definition]." []
synonym: "jejunal submucosa" EXACT []
synonym: "jejunum submucosa" EXACT []
is_a: UBERON:0001205 ! submucosa of small intestine
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0003334
name: serosa of rectum
def: "A serous membrane that is part of a rectum [Automatically generated definition]." []
synonym: "rectal serosa" EXACT []
synonym: "rectum serosa" EXACT []
synonym: "rectum serous membrane" EXACT []
synonym: "serous membrane of rectum" EXACT []
synonym: "visceral peritoneum of rectum" EXACT []
is_a: UBERON:0001209 ! serosa of large intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0003335
name: serosa of colon
def: "A serous membrane that is part of a colon [Automatically generated definition]." []
synonym: "colon serosa" EXACT []
synonym: "colon serous membrane" EXACT []
synonym: "colonic serosa" EXACT []
synonym: "large bowel serosa" EXACT []
synonym: "large bowel serous membrane" EXACT []
synonym: "serosa of large bowel" EXACT []
synonym: "serous membrane of colon" EXACT []
synonym: "serous membrane of large bowel" EXACT []
synonym: "visceral peritoneum of colon" EXACT []
is_a: UBERON:0001209 ! serosa of large intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0003336
name: serosa of duodenum
def: "A serous membrane that is part of a duodenum [Automatically generated definition]." []
synonym: "doudenal serosa" EXACT []
synonym: "duodenal serosa" EXACT []
synonym: "duodenum serosa" EXACT []
synonym: "duodenum serous membrane" EXACT []
synonym: "serous membrane of duodenum" EXACT []
synonym: "visceral peritoneum of duodenum" EXACT []
is_a: UBERON:0001206 ! serosa of small intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0003337
name: serosa of jejunum
def: "A serous membrane that is part of a jejunum [Automatically generated definition]." []
synonym: "jejunal serosa" EXACT []
synonym: "jejunum serosa" EXACT []
synonym: "jejunum serous membrane" EXACT []
synonym: "serous membrane of jejunum" EXACT []
synonym: "visceral peritoneum of jejunum" EXACT []
is_a: UBERON:0001206 ! serosa of small intestine
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0003338
name: ganglion of peripheral nervous system
def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." []
synonym: "peripheral nervous system ganglion" EXACT []
is_a: UBERON:0000045 ! ganglion
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0000010 ! peripheral nervous system
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0003339
name: ganglion of central nervous system
def: "A ganglion that is part of a central nervous system [Automatically generated definition]." []
synonym: "central nervous system ganglion" EXACT []
synonym: "ganglion of neuraxis" EXACT []
synonym: "neuraxis ganglion" EXACT []
is_a: UBERON:0000045 ! ganglion
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0003342
name: mucosa of anal canal
def: "A mucosa that is part of an anal canal [Automatically generated definition]." []
synonym: "anal canal mucosa" EXACT []
synonym: "anal canal mucosa of organ" EXACT []
synonym: "anal canal mucous membrane" EXACT []
synonym: "anal canal organ mucosa" EXACT []
synonym: "anal canal viewed anatomically mucosa" EXACT []
synonym: "anal canal viewed anatomically mucosa of organ" EXACT []
synonym: "anal canal viewed anatomically mucous membrane" EXACT []
synonym: "anal canal viewed anatomically organ mucosa" EXACT []
synonym: "anal mucosa" EXACT []
synonym: "anal mucous membrane" EXACT []
synonym: "anal region mucosa" EXACT []
synonym: "anal region mucosa of organ" EXACT []
synonym: "anal region mucous membrane" EXACT []
synonym: "anal region organ mucosa" EXACT []
synonym: "anatomical anal canal mucosa" EXACT []
synonym: "anatomical anal canal mucosa of organ" EXACT []
synonym: "anatomical anal canal mucous membrane" EXACT []
synonym: "anatomical anal canal organ mucosa" EXACT []
synonym: "mucosa of anal canal viewed anatomically" EXACT []
synonym: "mucosa of anal region" EXACT []
synonym: "mucosa of anatomical anal canal" EXACT []
synonym: "mucosa of organ of anal canal" EXACT []
synonym: "mucosa of organ of anal canal viewed anatomically" EXACT []
synonym: "mucosa of organ of anal region" EXACT []
synonym: "mucosa of organ of anatomical anal canal" EXACT []
synonym: "mucous membrane of anal canal" EXACT []
synonym: "mucous membrane of anal canal viewed anatomically" EXACT []
synonym: "mucous membrane of anal region" EXACT []
synonym: "mucous membrane of anatomical anal canal" EXACT []
synonym: "organ mucosa of anal canal" EXACT []
synonym: "organ mucosa of anal canal viewed anatomically" EXACT []
synonym: "organ mucosa of anal region" EXACT []
synonym: "organ mucosa of anatomical anal canal" EXACT []
is_a: UBERON:0001207 ! mucosa of large intestine
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0003343
name: mucosa of oral region
def: "A mucosa that is part of a oral opening [Automatically generated definition]." []
synonym: "mucosa of oral opening" EXACT []
synonym: "mucosa of oral part of face" EXACT []
synonym: "mucosa of organ of oral opening" EXACT []
synonym: "mucosa of organ of oral part of face" EXACT []
synonym: "mucosa of organ of oral region" EXACT []
synonym: "mucosa of organ of subdivision of mouth" EXACT []
synonym: "mucosa of subdivision of mouth" EXACT []
synonym: "mucous membrane of oral opening" EXACT []
synonym: "mucous membrane of oral part of face" EXACT []
synonym: "mucous membrane of oral region" EXACT []
synonym: "mucous membrane of subdivision of mouth" EXACT []
synonym: "oral opening mucosa" EXACT []
synonym: "oral opening mucosa of organ" EXACT []
synonym: "oral opening mucous membrane" EXACT []
synonym: "oral opening organ mucosa" EXACT []
synonym: "oral part of face mucosa" EXACT []
synonym: "oral part of face mucosa of organ" EXACT []
synonym: "oral part of face mucous membrane" EXACT []
synonym: "oral part of face organ mucosa" EXACT []
synonym: "oral region mucosa" EXACT []
synonym: "oral region mucosa of organ" EXACT []
synonym: "oral region mucous membrane" EXACT []
synonym: "oral region organ mucosa" EXACT []
synonym: "organ mucosa of oral opening" EXACT []
synonym: "organ mucosa of oral part of face" EXACT []
synonym: "organ mucosa of oral region" EXACT []
synonym: "organ mucosa of subdivision of mouth" EXACT []
synonym: "subdivision of mouth mucosa" EXACT []
synonym: "subdivision of mouth mucosa of organ" EXACT []
synonym: "subdivision of mouth mucous membrane" EXACT []
synonym: "subdivision of mouth organ mucosa" EXACT []
is_a: UBERON:0003729 ! mouth mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000166 ! oral opening
relationship: part_of UBERON:0000166 ! oral opening

[Term]
id: UBERON:0003346
name: mucosa of rectum
def: "A mucosa that is part of a rectum [Automatically generated definition]." []
synonym: "mucosa of organ of rectum" EXACT []
synonym: "mucous membrane of rectum" EXACT []
synonym: "organ mucosa of rectum" EXACT []
synonym: "rectal mucosa" EXACT []
synonym: "rectal mucous membrane" EXACT []
synonym: "rectum mucosa" EXACT []
synonym: "rectum mucosa of organ" EXACT []
synonym: "rectum mucous membrane" EXACT []
synonym: "rectum organ mucosa" EXACT []
is_a: UBERON:0001207 ! mucosa of large intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0003350
name: epithelium of mucosa
def: "A layer of epithelial cells on the surface of the mucosa." []
synonym: "lamina epithelialis mucosa" RELATED []
synonym: "lamina epithelialis mucosae" RELATED []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000344 ! mucosa
relationship: part_of UBERON:0000344 ! mucosa

[Term]
id: UBERON:0003351
name: pharyngeal epithelium
def: "An epithelium that is part of a pharynx [Automatically generated definition]." []
synonym: "epithelial tissue of pharynx" EXACT []
synonym: "epithelium of pharynx" EXACT []
synonym: "pharynx epithelial tissue" EXACT []
synonym: "pharynx epithelium" EXACT []
is_a: UBERON:0003929 ! digestive tract epithelium
is_a: UBERON:0004807 ! respiratory system epithelium
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0003352
name: epithelium of midgut
def: "An epithelium that is part of a midgut." []
synonym: "epithelial tissue of midgut" EXACT []
synonym: "midgut epithelial tissue" EXACT []
synonym: "midgut epithelium" EXACT []
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001045 ! midgut
relationship: part_of UBERON:0001045 ! midgut

[Term]
id: UBERON:0003353
name: epithelium of hindgut
def: "An epithelium that is part of a hindgut [Automatically generated definition]." []
synonym: "epithelial tissue of hindgut" EXACT []
synonym: "hindgut epithelial tissue" EXACT []
synonym: "hindgut epithelium" EXACT []
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001046 ! hindgut
relationship: part_of UBERON:0001046 ! hindgut

[Term]
id: UBERON:0003354
name: epithelium of rectum
def: "An epithelium that is part of a rectum [Automatically generated definition]." []
synonym: "epithelial tissue of rectum" EXACT []
synonym: "rectal epithelium" EXACT []
synonym: "rectum epithelial tissue" EXACT []
synonym: "rectum epithelium" EXACT []
is_a: UBERON:0001278 ! epithelium of large intestine
is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0003357
name: epithelium of tongue
def: "An epithelium that is part of a tongue [Automatically generated definition]." []
synonym: "epithelial tissue of tongue" EXACT []
synonym: "lingual epithelium" RELATED []
synonym: "tongue epithelial tissue" EXACT []
synonym: "tongue epithelium" EXACT []
is_a: UBERON:0003929 ! digestive tract epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0019304 ! sensory organ epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0003364
name: epithelium of right lung
def: "An epithelium that is part of a right lung [Automatically generated definition]." []
synonym: "epithelial tissue of right lung" EXACT []
synonym: "right lung epithelial tissue" EXACT []
synonym: "right lung epithelium" EXACT []
is_a: UBERON:0000115 ! lung epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0003365
name: epithelium of left lung
def: "An epithelium that is part of a left lung [Automatically generated definition]." []
synonym: "epithelial tissue of left lung" EXACT []
synonym: "left lung epithelial tissue" EXACT []
synonym: "left lung epithelium" EXACT []
is_a: UBERON:0000115 ! lung epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0003367
name: epithelium of vomeronasal organ
def: "An epithelium that is part of a vomeronasal organ [Automatically generated definition]." []
synonym: "epithelial tissue of Jacobson's organ" EXACT []
synonym: "epithelial tissue of vomeronasal organ" EXACT []
synonym: "epithelium of Jacobson's organ" EXACT []
synonym: "Jacobson's organ epithelial tissue" EXACT []
synonym: "Jacobson's organ epithelium" EXACT []
synonym: "vomeronasal epithelium" EXACT []
synonym: "vomeronasal organ epithelial tissue" EXACT []
synonym: "vomeronasal organ epithelium" EXACT []
synonym: "vomeronasal organ sensory epithelium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0019306 ! nose epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002255 ! vomeronasal organ
relationship: develops_from UBERON:0001997 ! olfactory epithelium
relationship: part_of UBERON:0002255 ! vomeronasal organ

[Term]
id: UBERON:0003371
name: pelvic appendage bud ectoderm
def: "An unilaminar epithelium that surrounds a pelvic appendage bud." []
synonym: "hindlimb bud ectoderm" NARROW []
synonym: "hindlimb ectoderm" EXACT []
synonym: "hindlimb ectoderm" NARROW []
synonym: "leg ectoderm" RELATED []
synonym: "lower limb bud ectoderm" NARROW []
synonym: "pelvic fin bud ectoderm" NARROW []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0005420 ! pelvic appendage bud

[Term]
id: UBERON:0003372
name: pectoral appendage bud ectoderm
def: "An unilaminar epithelium that surrounds a pectoral appendage bud." []
synonym: "arm ectoderm" RELATED []
synonym: "forelimb bud ectoderm" NARROW []
synonym: "forelimb ectoderm" NARROW []
synonym: "pectoral fin bud ectoderm" NARROW []
synonym: "upper limb bud ectoderm" NARROW []
synonym: "wing ectoderm" NARROW []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0005419 ! pectoral appendage bud

[Term]
id: UBERON:0003373
name: ectoderm of footplate
def: "An ectoderm that is part of a footplate." []
is_a: UBERON:0000924 ! ectoderm
intersection_of: UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0006871 ! footplate
relationship: part_of UBERON:0006871 ! footplate

[Term]
id: UBERON:0003374
name: chorionic ectoderm
def: "A extraembryonic structure that develops_from a ectoderm and is part of a chorion." []
synonym: "chorion ectoderm" EXACT []
synonym: "chorion epithelium" RELATED []
synonym: "chorionic epithelium" RELATED []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000478 ! extraembryonic structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0003124 ! chorion
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0003124 ! chorion

[Term]
id: UBERON:0003381
name: cardiac muscle of right ventricle
def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." []
synonym: "cardiac muscle tissue of right ventricle" EXACT []
synonym: "right ventricle cardiac muscle" RELATED []
synonym: "right ventricular cardiac muscle tissue" EXACT []
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: UBERON:0003382
name: cardiac muscle of left ventricle
def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." []
synonym: "cardiac muscle tissue of left ventricle" EXACT []
synonym: "left ventricle cardiac muscle" RELATED []
synonym: "left ventricular cardiac muscle tissue" EXACT []
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: UBERON:0003383
name: cardiac muscle tissue of interventricular septum
def: "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." []
synonym: "cardiac muscle of interventricular septum" EXACT []
synonym: "cardiac muscle tissue of interventricular septum" EXACT []
synonym: "interventricular septum cardiac muscle" EXACT []
synonym: "interventricular septum heart muscle" EXACT []
synonym: "interventricular septum muscle" RELATED []
synonym: "interventricular septum myocardium" EXACT []
is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum
is_a: UBERON:0004667 ! interventricular septum muscular part
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: UBERON:0003384
name: skeletal muscle tissue of pharynx
def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." []
synonym: "pharynx skeletal muscle" EXACT []
synonym: "pharynx skeletal muscle tissue" EXACT []
synonym: "skeletal muscle tissue of pharynx" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0004830 ! respiratory system skeletal muscle
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0003386
name: smooth muscle of eye
def: "any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" []
synonym: "ocular smooth muscle" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0003387
name: smooth muscle of trachea
def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." []
synonym: "trachea smooth muscle" EXACT []
synonym: "tracheal smooth muscle" EXACT []
is_a: UBERON:0004233 ! lower respiratory tract smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003388
name: mesothelium of pericardial cavity
def: "A mesothelium that is part of a pericardium [Automatically generated definition]." []
synonym: "cavity of pericardial sac meso-epithelium" EXACT []
synonym: "cavity of pericardial sac mesothelium" EXACT []
synonym: "meso-epithelium of cavity of pericardial sac" EXACT []
synonym: "meso-epithelium of pericardial cavity" EXACT []
synonym: "mesothelium of cavity of pericardial sac" EXACT []
synonym: "pericardial cavity meso-epithelium" EXACT []
synonym: "pericardial cavity mesothelium" EXACT []
is_a: UBERON:0001136 ! mesothelium
intersection_of: UBERON:0001136 ! mesothelium
intersection_of: part_of UBERON:0002407 ! pericardium
relationship: part_of UBERON:0002407 ! pericardium

[Term]
id: UBERON:0003393
name: mesentery of urinary system
def: "A mesentery that is part of a urinary system [Automatically generated definition]." []
synonym: "excretory system mesentery" EXACT []
synonym: "mesentery of excretory system" EXACT []
synonym: "mesentery of renal system" EXACT []
synonym: "mesentery of systema urinaria" EXACT []
synonym: "renal system mesentery" EXACT []
synonym: "systema urinaria mesentery" EXACT []
synonym: "urinary system mesentery" EXACT []
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0003394
name: mesentery of hindgut
def: "A mesentery that is part of a hindgut [Automatically generated definition]." []
synonym: "hindgut mesentery" EXACT []
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001046 ! hindgut
relationship: part_of UBERON:0001046 ! hindgut

[Term]
id: UBERON:0003395
name: mesentery of rectum
def: "A mesentery that is part of a rectum [Automatically generated definition]." []
synonym: "rectum mesentery" EXACT []
is_a: UBERON:0003334 ! serosa of rectum
is_a: UBERON:0004854 ! gastrointestinal system mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0003396
name: mesentery of colon
def: "A mesentery that is part of a colon [Automatically generated definition]." []
synonym: "colon mesentery" EXACT []
synonym: "large bowel mesentery" EXACT []
synonym: "large intestinal mesentery" EXACT []
synonym: "mesentery of large bowel" EXACT []
synonym: "mesentery of large intestine" EXACT []
is_a: UBERON:0003335 ! serosa of colon
is_a: UBERON:0004854 ! gastrointestinal system mesentery
is_a: UBERON:0007826 ! peritoneal mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0003397
name: mesentery of duodenum
def: "A mesentery that is part of a duodenum [Automatically generated definition]." []
synonym: "duodenum mesentery" EXACT []
is_a: UBERON:0001170 ! mesentery of small intestine
is_a: UBERON:0003336 ! serosa of duodenum
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0003398
name: mesentery of jejunum
def: "A mesentery that is part of a jejunum [Automatically generated definition]." []
synonym: "jejunal mesentery" EXACT []
synonym: "jejunum mesentery" EXACT []
synonym: "mesojejunum" EXACT []
is_a: UBERON:0001170 ! mesentery of small intestine
is_a: UBERON:0003337 ! serosa of jejunum
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0003406
name: cartilage of respiratory system
def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius cartilage" EXACT []
synonym: "cartilage of apparatus respiratorius" EXACT []
synonym: "respiratory system cartilage" EXACT []
is_a: UBERON:0007844 ! cartilage element
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003408
name: gland of gut
def: "A gland that is part of a digestive tract [Automatically generated definition]." []
synonym: "digestive tract gland" EXACT []
synonym: "gland of digestive tract" EXACT []
synonym: "gland of lower gastrointestinal tract" EXACT []
synonym: "gut gland" EXACT []
synonym: "lower gastrointestinal tract gland" EXACT []
is_a: UBERON:0002530 ! gland
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0003409
name: gland of tongue
def: "Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue." []
synonym: "lingual gland" EXACT []
synonym: "tongue gland" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010047 ! oral gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0003412
name: pelvic appendage bud mesenchyme
def: "Mesenchyme that is part of a pelvic appendage bud." []
synonym: "hindlimb bud mesenchyme" NARROW []
synonym: "leg mesenchyme" EXACT []
synonym: "lower limb bud mesenchyme" EXACT []
synonym: "mesoderm pelvic fin bud" NARROW []
synonym: "pelvic fin bud mesenchyme" NARROW []
is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0005420 ! pelvic appendage bud
relationship: develops_from UBERON:0005730 ! pelvic appendage field
relationship: part_of UBERON:0005420 ! pelvic appendage bud

[Term]
id: UBERON:0003413
name: pectoral appendage bud mesenchyme
def: "Mesenchyme that is part of a pectoral appendage bud." []
synonym: "arm mesenchyme" NARROW []
synonym: "forelimb bud mesenchyme" NARROW []
synonym: "mesoderm pectoral fin bud" NARROW []
synonym: "pectoral fin bud mesenchyme" NARROW []
synonym: "upper limb bud mesenchyme" NARROW []
synonym: "wing mesenchyme" NARROW []
is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0005419 ! pectoral appendage bud
relationship: develops_from UBERON:0005729 ! pectoral appendage field
relationship: part_of UBERON:0005419 ! pectoral appendage bud

[Term]
id: UBERON:0003416
name: mesenchyme of tongue
def: "Mesenchyme that is part of a developing tongue [Automatically generated definition]." []
synonym: "tongue mesenchyme" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005253 ! head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0003421
name: mesenchyme of vomeronasal organ
def: "Mesenchyme that is part of a developing vomeronasal organ [Automatically generated definition]." []
synonym: "Jacobson's organ mesenchyme" EXACT []
synonym: "mesenchyme of Jacobson's organ" EXACT []
synonym: "vomeronasal mesenchyme" EXACT []
synonym: "vomeronasal organ mesenchyme" EXACT []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
is_a: UBERON:0009891 ! facial mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002255 ! vomeronasal organ
relationship: develops_from UBERON:0009204 ! medial nasal process mesenchyme
relationship: part_of UBERON:0002255 ! vomeronasal organ

[Term]
id: UBERON:0003422
name: mesenchyme of umbilical cord
def: "A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP]" []
synonym: "umbilical cord mesenchyme" EXACT []
synonym: "Wharton's jelly" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005292 ! extraembryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord

[Term]
id: UBERON:0003426
name: dermis adipose tissue
def: "An adipose tissue that is part of a dermis [Automatically generated definition]." []
synonym: "adipose tissue of dermis" EXACT []
synonym: "dermis fat tissue" EXACT []
synonym: "dermis fatty tissue" EXACT []
synonym: "fat tissue of dermis" EXACT []
synonym: "fatty tissue of dermis" EXACT []
is_a: UBERON:0001013 ! adipose tissue
is_a: UBERON:0003585 ! dermis connective tissue
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis

[Term]
id: UBERON:0003429
name: abdomen nerve
def: "A nerve that is part of an abdomen [Automatically generated definition]." []
synonym: "nerve of abdomen" EXACT []
is_a: UBERON:0003825 ! nerve of abdominal segment
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0003431
name: leg nerve
def: "A nerve that is part of a leg [Automatically generated definition]." []
synonym: "nerve of leg" EXACT []
is_a: UBERON:0003442 ! hindlimb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0003432
name: chest nerve
def: "A nerve that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region nerve" EXACT []
synonym: "anterolateral part of thorax nerve" EXACT []
synonym: "front of thorax nerve" EXACT []
synonym: "nerve of anterior thoracic region" EXACT []
synonym: "nerve of anterolateral part of thorax" EXACT []
synonym: "nerve of chest" EXACT []
synonym: "nerve of front of thorax" EXACT []
is_a: UBERON:0003824 ! nerve of thoracic segment
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0003433
name: arm nerve
def: "A nerve that is part of an arm [Automatically generated definition]." []
synonym: "brachial region nerve" EXACT []
synonym: "nerve of arm" EXACT []
synonym: "nerve of brachial region" EXACT []
synonym: "nerve of proximal segment of free upper limb" EXACT []
synonym: "proximal segment of free upper limb nerve" EXACT []
is_a: UBERON:0003441 ! forelimb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0003435
name: pedal digit nerve
def: "A nerve that is part of a toe [Automatically generated definition]." []
synonym: "digit of foot nerve" EXACT []
synonym: "digit of terminal segment of free lower limb nerve" EXACT []
synonym: "digitus pedis nerve" EXACT []
synonym: "foot digit nerve" EXACT []
synonym: "foot digit nerve" NARROW []
synonym: "hind limb digit nerve" EXACT []
synonym: "nerve of digit of foot" EXACT []
synonym: "nerve of digit of terminal segment of free lower limb" EXACT []
synonym: "nerve of digitus pedis" EXACT []
synonym: "nerve of foot digit" EXACT []
synonym: "nerve of terminal segment of free lower limb digit" EXACT []
synonym: "nerve of toe" EXACT []
synonym: "terminal segment of free lower limb digit nerve" EXACT []
synonym: "toe nerve" EXACT []
is_a: UBERON:0003445 ! pes nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0003436
name: shoulder nerve
def: "A nerve that is part of a shoulder [Automatically generated definition]." []
synonym: "nerve of shoulder" EXACT []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0003439
name: nerve of trunk region
def: "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." []
synonym: "nerve of torso" EXACT []
synonym: "nerve of trunk" EXACT []
synonym: "torso nerve" EXACT []
synonym: "trunk nerve" RELATED []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0003440
name: limb nerve
def: "A nerve that is part of a limb [Automatically generated definition]." []
synonym: "nerve of limb" EXACT []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0003441
name: forelimb nerve
def: "A nerve that is part of a forelimb [Automatically generated definition]." []
synonym: "anteriormost limb nerve" EXACT []
synonym: "fore limb nerve" EXACT []
synonym: "nerve of anteriormost limb" EXACT []
synonym: "nerve of fore limb" EXACT []
synonym: "nerve of forelimb" EXACT []
synonym: "nerve of superior member" EXACT []
synonym: "nerve of upper extremity" EXACT []
synonym: "superior member nerve" EXACT []
synonym: "upper extremity nerve" EXACT []
synonym: "wing nerve" NARROW []
is_a: UBERON:0003440 ! limb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003442
name: hindlimb nerve
def: "A nerve that is part of a hindlimb [Automatically generated definition]." []
synonym: "hind limb nerve" EXACT []
synonym: "inferior member nerve" EXACT []
synonym: "lower extremity nerve" EXACT []
synonym: "nerve of hind limb" EXACT []
synonym: "nerve of hindlimb" EXACT []
synonym: "nerve of inferior member" EXACT []
synonym: "nerve of lower extremity" EXACT []
is_a: UBERON:0003440 ! limb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003444
name: pelvis nerve
def: "A nerve that is part of a pelvis [Automatically generated definition]." []
synonym: "nerve of pelvis" EXACT []
is_a: UBERON:0003825 ! nerve of abdominal segment
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0003445
name: pes nerve
def: "A nerve that is part of a foot [Automatically generated definition]." []
synonym: "autopod of hind limb nerve" EXACT []
synonym: "autopod of hindlimb nerve" EXACT []
synonym: "autopod of inferior member nerve" EXACT []
synonym: "autopod of lower extremity nerve" EXACT []
synonym: "distal free limb segment of hind limb nerve" EXACT []
synonym: "distal free limb segment of hindlimb nerve" EXACT []
synonym: "distal free limb segment of inferior member nerve" EXACT []
synonym: "distal free limb segment of lower extremity nerve" EXACT []
synonym: "foot nerve" EXACT []
synonym: "hind limb autopod nerve" EXACT []
synonym: "hind limb distal free limb segment nerve" EXACT []
synonym: "hindlimb autopod nerve" EXACT []
synonym: "hindlimb distal free limb segment nerve" EXACT []
synonym: "inferior member autopod nerve" EXACT []
synonym: "inferior member distal free limb segment nerve" EXACT []
synonym: "lower extremity autopod nerve" EXACT []
synonym: "lower extremity distal free limb segment nerve" EXACT []
synonym: "nerve of autopod of hind limb" EXACT []
synonym: "nerve of autopod of hindlimb" EXACT []
synonym: "nerve of autopod of inferior member" EXACT []
synonym: "nerve of autopod of lower extremity" EXACT []
synonym: "nerve of distal free limb segment of hind limb" EXACT []
synonym: "nerve of distal free limb segment of hindlimb" EXACT []
synonym: "nerve of distal free limb segment of inferior member" EXACT []
synonym: "nerve of distal free limb segment of lower extremity" EXACT []
synonym: "nerve of foot" EXACT []
synonym: "nerve of hind limb autopod" EXACT []
synonym: "nerve of hind limb distal free limb segment" EXACT []
synonym: "nerve of hindlimb autopod" EXACT []
synonym: "nerve of hindlimb distal free limb segment" EXACT []
synonym: "nerve of inferior member autopod" EXACT []
synonym: "nerve of inferior member distal free limb segment" EXACT []
synonym: "nerve of lower extremity autopod" EXACT []
synonym: "nerve of lower extremity distal free limb segment" EXACT []
synonym: "nerve of terminal segment of free lower limb" EXACT []
synonym: "terminal segment of free lower limb nerve" EXACT []
is_a: UBERON:0003442 ! hindlimb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0003447
name: digit nerve of manus
def: "A nerve that is part of a finger [Automatically generated definition]." []
synonym: "digit of hand nerve" EXACT []
synonym: "digit of terminal segment of free upper limb nerve" EXACT []
synonym: "digitus manus nerve" EXACT []
synonym: "finger nerve" EXACT []
synonym: "hand digit nerve" EXACT []
synonym: "nerve of digit of hand" EXACT []
synonym: "nerve of digit of terminal segment of free upper limb" EXACT []
synonym: "nerve of digitus manus" EXACT []
synonym: "nerve of finger" EXACT []
synonym: "nerve of hand digit" EXACT []
synonym: "nerve of terminal segment of free upper limb digit" EXACT []
synonym: "terminal segment of free upper limb digit nerve" EXACT []
is_a: UBERON:0003448 ! manus nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0003448
name: manus nerve
def: "A nerve that is part of a manus [Automatically generated definition]." []
synonym: "arm autopod nerve" EXACT []
synonym: "arm distal free limb segment nerve" EXACT []
synonym: "autopod of arm nerve" EXACT []
synonym: "autopod of brachial region nerve" EXACT []
synonym: "autopod of proximal segment of free upper limb nerve" EXACT []
synonym: "brachial region autopod nerve" EXACT []
synonym: "brachial region distal free limb segment nerve" EXACT []
synonym: "distal free limb segment of arm nerve" EXACT []
synonym: "distal free limb segment of brachial region nerve" EXACT []
synonym: "distal free limb segment of proximal segment of free upper limb nerve" EXACT []
synonym: "hand nerve" EXACT []
synonym: "nerve of arm autopod" EXACT []
synonym: "nerve of arm distal free limb segment" EXACT []
synonym: "nerve of autopod of arm" EXACT []
synonym: "nerve of autopod of brachial region" EXACT []
synonym: "nerve of autopod of proximal segment of free upper limb" EXACT []
synonym: "nerve of brachial region autopod" EXACT []
synonym: "nerve of brachial region distal free limb segment" EXACT []
synonym: "nerve of distal free limb segment of arm" EXACT []
synonym: "nerve of distal free limb segment of brachial region" EXACT []
synonym: "nerve of distal free limb segment of proximal segment of free upper limb" EXACT []
synonym: "nerve of manus" EXACT []
synonym: "nerve of proximal segment of free upper limb autopod" EXACT []
synonym: "nerve of proximal segment of free upper limb distal free limb segment" EXACT []
synonym: "nerve of terminal segment of free upper limb" EXACT []
synonym: "proximal segment of free upper limb autopod nerve" EXACT []
synonym: "proximal segment of free upper limb distal free limb segment nerve" EXACT []
synonym: "terminal segment of free upper limb nerve" EXACT []
is_a: UBERON:0003441 ! forelimb nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0003453
name: large intestine Peyer's patch
def: "A Peyer's patch that is part of a large intestine." []
synonym: "large intestine Peyer's patch" EXACT []
synonym: "Peyer's patch of large intestine" EXACT []
synonym: "solitary lymphatic follicle of large intestine" RELATED []
synonym: "solitary lymphoid follicle of subdivision of large intestine" RELATED []
is_a: UBERON:0001211 ! Peyer's patch
intersection_of: UBERON:0001211 ! Peyer's patch
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine

[Term]
id: UBERON:0003454
name: small intestine Peyer's patch
def: "nodular lymphoid structures on the serosal surface of the small intestine." []
synonym: "aggregated lymphoid follicle of small intestine" EXACT []
synonym: "noduli lymphoidei aggregati intestini tenuis" EXACT []
synonym: "Peyer's patch" BROAD []
synonym: "Peyer's patch of small bowel" EXACT []
synonym: "Peyer's patch of small intestine" EXACT []
synonym: "small bowel Peyer's patch" EXACT []
synonym: "small intestine Peyer's patch" EXACT []
is_a: UBERON:0001211 ! Peyer's patch
intersection_of: UBERON:0001211 ! Peyer's patch
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001204 ! mucosa of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0003455
name: inner renal medulla loop of henle
def: "A loop of Henle that is part of a inner medulla of kidney [Automatically generated definition]." []
synonym: "Henle loop of inner medulla of kidney" EXACT []
synonym: "Henle loop of inner renal medulla" EXACT []
synonym: "Henle loop of inner zone of medulla of kidney" EXACT []
synonym: "Henle loop of inner zone of renal medulla" EXACT []
synonym: "henle's loop of inner medulla of kidney" EXACT []
synonym: "henle's loop of inner renal medulla" EXACT []
synonym: "henle's loop of inner zone of medulla of kidney" EXACT []
synonym: "henle's loop of inner zone of renal medulla" EXACT []
synonym: "inner medulla of kidney Henle loop" EXACT []
synonym: "inner medulla of kidney henle's loop" EXACT []
synonym: "inner medulla of kidney loop of Henle" EXACT []
synonym: "inner renal medulla Henle loop" EXACT []
synonym: "inner renal medulla henle's loop" EXACT []
synonym: "inner renal medulla loop of Henle" EXACT []
synonym: "inner zone of medulla of kidney Henle loop" EXACT []
synonym: "inner zone of medulla of kidney henle's loop" EXACT []
synonym: "inner zone of medulla of kidney loop of Henle" EXACT []
synonym: "inner zone of renal medulla Henle loop" EXACT []
synonym: "inner zone of renal medulla henle's loop" EXACT []
synonym: "inner zone of renal medulla loop of Henle" EXACT []
synonym: "kidney inner medulla loop of henle" EXACT []
synonym: "loop of Henle of inner medulla of kidney" EXACT []
synonym: "loop of Henle of inner renal medulla" EXACT []
synonym: "loop of Henle of inner zone of medulla of kidney" EXACT []
synonym: "loop of Henle of inner zone of renal medulla" EXACT []
is_a: UBERON:0034997 ! renal medulla loop of henle
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney

[Term]
id: UBERON:0003456
name: respiratory system lymphatic vessel
def: "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius lymph vessel" EXACT []
synonym: "apparatus respiratorius lymphatic vessel" EXACT []
synonym: "lymph vessel of apparatus respiratorius" EXACT []
synonym: "lymph vessel of respiratory system" EXACT []
synonym: "lymphatic vessel of apparatus respiratorius" EXACT []
synonym: "lymphatic vessel of respiratory system" EXACT []
synonym: "respiratory system lymph vessel" EXACT []
is_a: UBERON:0001473 ! lymphatic vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003457
name: head bone
def: "A bone that is part of a head [Automatically generated definition]." []
synonym: "adult head bone" EXACT []
synonym: "adult head bone organ" EXACT []
synonym: "bone of adult head" EXACT []
synonym: "bone of head" EXACT []
synonym: "bone organ of adult head" EXACT []
synonym: "bone organ of head" EXACT []
synonym: "craniofacial bone" RELATED []
synonym: "head bone organ" EXACT []
is_a: UBERON:0007914 ! bone of craniocervical region
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0003459
name: chest bone
def: "A bone that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region bone" EXACT []
synonym: "anterior thoracic region bone organ" EXACT []
synonym: "anterolateral part of thorax bone" EXACT []
synonym: "anterolateral part of thorax bone organ" EXACT []
synonym: "bone of anterior thoracic region" EXACT []
synonym: "bone of anterolateral part of thorax" EXACT []
synonym: "bone of chest" EXACT []
synonym: "bone of front of thorax" EXACT []
synonym: "bone organ of anterior thoracic region" EXACT []
synonym: "bone organ of anterolateral part of thorax" EXACT []
synonym: "bone organ of chest" EXACT []
synonym: "bone organ of front of thorax" EXACT []
synonym: "chest bone organ" EXACT []
synonym: "front of thorax bone" EXACT []
synonym: "front of thorax bone organ" EXACT []
is_a: UBERON:0003827 ! thoracic segment bone
is_a: UBERON:0005175 ! chest organ
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0003460
name: arm bone
def: "A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia" []
synonym: "arm bone organ" EXACT []
synonym: "bone of arm" EXACT []
synonym: "bone of brachial region" EXACT []
synonym: "bone of proximal segment of free upper limb" EXACT []
synonym: "bone of upper extremity" EXACT []
synonym: "bone organ of arm" EXACT []
synonym: "bone organ of brachial region" EXACT []
synonym: "bone organ of proximal segment of free upper limb" EXACT []
synonym: "brachial region bone" EXACT []
synonym: "brachial region bone organ" EXACT []
synonym: "proximal segment of free upper limb bone" EXACT []
synonym: "proximal segment of free upper limb bone organ" EXACT []
is_a: UBERON:0008962 ! forelimb bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001440 ! forelimb skeleton
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0003461
name: shoulder bone
def: "A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods." []
synonym: "bone of shoulder" EXACT []
synonym: "shoulder-articulating bone" EXACT []
is_a: UBERON:0010741 ! bone of pectoral complex
relationship: part_of UBERON:0012475 ! skeleton of pectoral complex

[Term]
id: UBERON:0003462
name: facial bone
def: "A bone that is part of a facial skeleton [Automatically generated definition]." []
synonym: "bone of facial skeleton" EXACT []
synonym: "bone of viscerocranium" RELATED []
synonym: "facial bone" EXACT []
synonym: "facial skeleton bone" EXACT []
synonym: "viscerocranium bone" RELATED []
is_a: UBERON:0003457 ! head bone
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0011156 ! facial skeleton
relationship: part_of UBERON:0011156 ! facial skeleton

[Term]
id: UBERON:0003463
name: trunk bone
def: "A bone that is part of a trunk [Automatically generated definition]." []
synonym: "bone of torso" EXACT []
synonym: "bone of trunk" EXACT []
synonym: "bone organ of torso" EXACT []
synonym: "bone organ of trunk" EXACT []
synonym: "torso bone" EXACT []
synonym: "torso bone organ" EXACT []
synonym: "trunk bone organ" EXACT []
is_a: UBERON:0001474 ! bone element
is_a: UBERON:0005177 ! trunk region element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0003464
name: hindlimb bone
def: "A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle)" []
synonym: "bone of hind limb" EXACT []
synonym: "bone of hindlimb" EXACT []
synonym: "bone of inferior member" EXACT []
synonym: "bone of lower extremity" EXACT []
synonym: "bone organ of hind limb" EXACT []
synonym: "bone organ of hindlimb" EXACT []
synonym: "bone organ of inferior member" EXACT []
synonym: "bone organ of lower extremity" EXACT []
synonym: "hind limb bone" EXACT []
synonym: "hind limb bone organ" EXACT []
synonym: "hindlimb bone organ" EXACT []
synonym: "inferior member bone" EXACT []
synonym: "inferior member bone organ" EXACT []
synonym: "lower extremity bone" EXACT []
synonym: "lower extremity bone organ" EXACT []
is_a: UBERON:0002428 ! limb bone
is_a: UBERON:0010742 ! bone of pelvic complex
is_a: UBERON:0015022 ! hindlimb endochondral element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: develops_from UBERON:0010885 ! hindlimb cartilage element
relationship: part_of UBERON:0001441 ! hindlimb skeleton
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003469
name: respiratory system artery
def: "An artery that is part of a respiratory system [Automatically generated definition]." []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0003643 ! respiratory system arterial blood vessel
intersection_of: UBERON:0001637 ! artery
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003475
name: ureteric vein
def: "A vein that is part of a ureter [Automatically generated definition]." []
synonym: "ureter vein" EXACT []
synonym: "vein of ureter" EXACT []
is_a: UBERON:0001638 ! vein
is_a: UBERON:0003520 ! pelvis blood vessel
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter

[Term]
id: UBERON:0003476
name: respiratory system venous blood vessel
def: "A vein that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius vein" EXACT []
synonym: "respiratory system vein" EXACT []
synonym: "vein of apparatus respiratorius" EXACT []
synonym: "vein of respiratory system" EXACT []
is_a: UBERON:0001638 ! vein

[Term]
id: UBERON:0003483
name: thymus lymphoid tissue
def: "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." []
synonym: "lymphoid tissue of thymus" EXACT []
synonym: "lymphoid tissue of thymus gland" EXACT []
synonym: "thymus gland lymphoid tissue" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001744 ! lymphoid tissue
intersection_of: UBERON:0001744 ! lymphoid tissue
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0003484
name: eye sebaceous gland
def: "A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland." []
synonym: "camera-type eye sebaceous gland" EXACT []
synonym: "sebaceous gland of camera-type eye" EXACT []
synonym: "sebaceous gland of vertebrate eye" EXACT []
synonym: "vertebrate eye sebaceous gland" EXACT []
is_a: UBERON:0003487 ! skin sebaceous gland
is_a: UBERON:0003605 ! eye skin gland
intersection_of: UBERON:0001821 ! sebaceous gland
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0003485
name: vagina sebaceous gland
def: "A sebaceous gland that is part of a vagina [Automatically generated definition]." []
synonym: "sebaceous gland of vagina" EXACT []
is_a: UBERON:0001821 ! sebaceous gland
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005398 ! female reproductive gland
intersection_of: UBERON:0001821 ! sebaceous gland
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0003487
name: skin sebaceous gland
def: "A holocrine gland of the dermis that secretes sebum into hair follicles." []
synonym: "cutaneous sebaceous gland" EXACT []
synonym: "sebaceous gland of skin" EXACT []
is_a: UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0011932 ! pilosebaceous unit

[Term]
id: UBERON:0003488
name: abdominal mammary gland
def: "A lactiferous gland that is part of the abdominal region [Automatically generated definition]." []
synonym: "abdomen lactiferous gland" EXACT []
synonym: "abdomen lobe of breast" EXACT []
synonym: "abdomen lobe of mammary gland" EXACT []
synonym: "abdomen mammary gland" EXACT []
synonym: "lactiferous gland of abdomen" EXACT []
synonym: "lobe of breast of abdomen" EXACT []
synonym: "lobe of mammary gland of abdomen" EXACT []
synonym: "mammary gland of abdomen" EXACT []
is_a: UBERON:0001911 ! mammary gland
is_a: UBERON:0005172 ! abdomen element
intersection_of: UBERON:0001911 ! mammary gland
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0003489
name: respiratory system capillary endothelium
def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius blood capillary endothelium" EXACT []
synonym: "apparatus respiratorius capillary endothelium" EXACT []
synonym: "apparatus respiratorius capillary vessel endothelium" EXACT []
synonym: "apparatus respiratorius endothelium of blood capillary" EXACT []
synonym: "apparatus respiratorius endothelium of capillary" EXACT []
synonym: "apparatus respiratorius endothelium of capillary vessel" EXACT []
synonym: "blood capillary endothelium of apparatus respiratorius" EXACT []
synonym: "blood capillary endothelium of respiratory system" EXACT []
synonym: "capillary endothelium of apparatus respiratorius" EXACT []
synonym: "capillary endothelium of respiratory system" EXACT []
synonym: "capillary vessel endothelium of apparatus respiratorius" EXACT []
synonym: "capillary vessel endothelium of respiratory system" EXACT []
synonym: "endothelium of blood capillary of apparatus respiratorius" EXACT []
synonym: "endothelium of blood capillary of respiratory system" EXACT []
synonym: "endothelium of capillary of apparatus respiratorius" EXACT []
synonym: "endothelium of capillary of respiratory system" EXACT []
synonym: "endothelium of capillary vessel of apparatus respiratorius" EXACT []
synonym: "endothelium of capillary vessel of respiratory system" EXACT []
synonym: "respiratory system blood capillary endothelium" EXACT []
synonym: "respiratory system capillary vessel endothelium" EXACT []
synonym: "respiratory system endothelium of blood capillary" EXACT []
synonym: "respiratory system endothelium of capillary" EXACT []
synonym: "respiratory system endothelium of capillary vessel" EXACT []
is_a: UBERON:0001915 ! endothelium of capillary
is_a: UBERON:0004702 ! respiratory system blood vessel endothelium
intersection_of: UBERON:0001915 ! endothelium of capillary
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003504 ! respiratory system blood vessel
relationship: part_of UBERON:0003526 ! respiratory system capillary

[Term]
id: UBERON:0003494
name: respiratory system venule
def: "A venule that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius venule" EXACT []
synonym: "venule of apparatus respiratorius" EXACT []
synonym: "venule of respiratory system" EXACT []
is_a: UBERON:0001979 ! venule
is_a: UBERON:0003504 ! respiratory system blood vessel
intersection_of: UBERON:0001979 ! venule
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003495
name: respiratory system arteriole
def: "An arteriole that is part of a respiratory system [Automatically generated definition]." []
is_a: UBERON:0001980 ! arteriole
is_a: UBERON:0003643 ! respiratory system arterial blood vessel
intersection_of: UBERON:0001980 ! arteriole
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003469 ! respiratory system artery

[Term]
id: UBERON:0003496
name: head blood vessel
def: "A blood vessel that is part of a head [Automatically generated definition]." []
synonym: "adult head blood vessel" EXACT []
synonym: "blood vessel of adult head" EXACT []
synonym: "blood vessel of head" EXACT []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0011362 ! cranial blood vasculature

[Term]
id: UBERON:0003497
name: abdomen blood vessel
def: "A blood vessel that is part of an abdomen [Automatically generated definition]." []
synonym: "blood vessel of abdomen" EXACT []
is_a: UBERON:0003835 ! abdominal segment blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0003498
name: heart blood vessel
def: "A blood vessel that is part of a heart [Automatically generated definition]." []
synonym: "blood vessel of heart" EXACT []
synonym: "cardiac blood vessel" RELATED []
is_a: UBERON:0003834 ! thoracic segment blood vessel
is_a: UBERON:0005985 ! coronary vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0018674 ! heart vasculature

[Term]
id: UBERON:0003499
name: brain blood vessel
def: "A blood vessel that is part of a brain [Automatically generated definition]." []
synonym: "blood vessel of brain" EXACT []
is_a: UBERON:0001981 ! blood vessel
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0008998 ! vasculature of brain

[Term]
id: UBERON:0003500
name: corneal blood vessel
def: "A blood vessel that is part of a cornea [Automatically generated definition]." []
synonym: "blood vessel of cornea" EXACT []
synonym: "cornea blood vessel" EXACT []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000964 ! cornea
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: UBERON:0003501
name: retina blood vessel
def: "A blood vessel that is part of a retina [Automatically generated definition]." []
synonym: "blood vessel of inner layer of eyeball" EXACT []
synonym: "blood vessel of retina" EXACT []
synonym: "blood vessel of tunica interna of eyeball" EXACT []
synonym: "inner layer of eyeball blood vessel" EXACT []
synonym: "retinal blood vessel" EXACT []
synonym: "tunica interna of eyeball blood vessel" EXACT []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0004864 ! vasculature of retina

[Term]
id: UBERON:0003503
name: leg blood vessel
def: "A blood vessel that is part of a leg [Automatically generated definition]." []
synonym: "blood vessel of leg" EXACT []
is_a: UBERON:0003516 ! hindlimb blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0003504
name: respiratory system blood vessel
def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius blood vessel" EXACT []
synonym: "blood vessel of apparatus respiratorius" EXACT []
synonym: "blood vessel of respiratory system" EXACT []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003505
name: trachea blood vessel
def: "A blood vessel that is part of a trachea." []
synonym: "blood vessel of trachea" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003504 ! respiratory system blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003506
name: chest blood vessel
def: "A blood vessel that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region blood vessel" EXACT []
synonym: "anterolateral part of thorax blood vessel" EXACT []
synonym: "blood vessel of anterior thoracic region" EXACT []
synonym: "blood vessel of anterolateral part of thorax" EXACT []
synonym: "blood vessel of chest" EXACT []
synonym: "blood vessel of front of thorax" EXACT []
synonym: "front of thorax blood vessel" EXACT []
is_a: UBERON:0003834 ! thoracic segment blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0003507
name: arm blood vessel
def: "A blood vessel that is part of an arm [Automatically generated definition]." []
synonym: "blood vessel of arm" EXACT []
synonym: "blood vessel of brachial region" EXACT []
synonym: "blood vessel of proximal segment of free upper limb" EXACT []
synonym: "brachial region blood vessel" EXACT []
synonym: "proximal segment of free upper limb blood vessel" EXACT []
is_a: UBERON:0003515 ! forelimb blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0003508
name: pedal digit blood vessel
def: "A blood vessel that is part of a toe [Automatically generated definition]." []
synonym: "blood vessel of digit of foot" EXACT []
synonym: "blood vessel of digit of terminal segment of free lower limb" EXACT []
synonym: "blood vessel of digitus pedis" EXACT []
synonym: "blood vessel of foot digit" EXACT []
synonym: "blood vessel of terminal segment of free lower limb digit" EXACT []
synonym: "blood vessel of toe" EXACT []
synonym: "digit of foot blood vessel" EXACT []
synonym: "digit of terminal segment of free lower limb blood vessel" EXACT []
synonym: "digitus pedis blood vessel" EXACT []
synonym: "foot digit blood vessel" EXACT []
synonym: "foot digit blood vessel" NARROW []
synonym: "hind limb digit blood vessel" EXACT []
synonym: "terminal segment of free lower limb digit blood vessel" EXACT []
synonym: "toe blood vessel" EXACT []
is_a: UBERON:0003521 ! pes blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0003509
name: arterial blood vessel
def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0004572 ! arterial system
relationship: part_of UBERON:0004572 ! arterial system

[Term]
id: UBERON:0003510
name: eyelid blood vessel
def: "A blood vessel that is part of a eyelid [Automatically generated definition]." []
synonym: "blepharon blood vessel" EXACT []
synonym: "blood vessel of blepharon" EXACT []
synonym: "blood vessel of eyelid" EXACT []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0003511
name: iris blood vessel
def: "A blood vessel that is part of a iris [Automatically generated definition]." []
synonym: "blood vessel of iris" EXACT []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0004118 ! vasculature of iris

[Term]
id: UBERON:0003512
name: lung blood vessel
def: "A blood vessel that is part of a lung [Automatically generated definition]." []
synonym: "blood vessel of lung" EXACT []
synonym: "pulmonary vascular element" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003504 ! respiratory system blood vessel
is_a: UBERON:0003834 ! thoracic segment blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0003513
name: trunk blood vessel
def: "A blood vessel that is part of a trunk [Automatically generated definition]." []
synonym: "blood vessel of torso" EXACT []
synonym: "blood vessel of trunk" EXACT []
synonym: "torso blood vessel" EXACT []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0003514
name: limb blood vessel
def: "A blood vessel that is part of a limb [Automatically generated definition]." []
synonym: "blood vessel of limb" EXACT []
is_a: UBERON:0007301 ! appendage blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0003515
name: forelimb blood vessel
def: "A blood vessel that is part of a forelimb [Automatically generated definition]." []
synonym: "anteriormost limb blood vessel" EXACT []
synonym: "blood vessel of anteriormost limb" EXACT []
synonym: "blood vessel of fore limb" EXACT []
synonym: "blood vessel of forelimb" EXACT []
synonym: "blood vessel of superior member" EXACT []
synonym: "blood vessel of upper extremity" EXACT []
synonym: "fore limb blood vessel" EXACT []
synonym: "superior member blood vessel" EXACT []
synonym: "upper extremity blood vessel" EXACT []
synonym: "wing blood vessel" NARROW []
is_a: UBERON:0003514 ! limb blood vessel
is_a: UBERON:0007300 ! pectoral appendage blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003516
name: hindlimb blood vessel
def: "A blood vessel that is part of a hindlimb [Automatically generated definition]." []
synonym: "blood vessel of hind limb" EXACT []
synonym: "blood vessel of hindlimb" EXACT []
synonym: "blood vessel of inferior member" EXACT []
synonym: "blood vessel of lower extremity" EXACT []
synonym: "hind limb blood vessel" EXACT []
synonym: "inferior member blood vessel" EXACT []
synonym: "lower extremity blood vessel" EXACT []
is_a: UBERON:0003514 ! limb blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003517
name: kidney blood vessel
def: "A blood vessel that is part of a kidney [Automatically generated definition]." []
synonym: "blood vessel of kidney" EXACT []
synonym: "renal blood vessel" EXACT []
is_a: UBERON:0003497 ! abdomen blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0006544 ! kidney vasculature

[Term]
id: UBERON:0003519
name: thoracic cavity blood vessel
def: "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." []
synonym: "blood vessel of cavity of chest" EXACT []
synonym: "blood vessel of cavity of thorax" EXACT []
synonym: "blood vessel of chest cavity" EXACT []
synonym: "blood vessel of pectoral cavity" EXACT []
synonym: "blood vessel of thoracic cavity" EXACT []
synonym: "cavity of chest blood vessel" EXACT []
synonym: "cavity of thorax blood vessel" EXACT []
synonym: "chest cavity blood vessel" EXACT []
synonym: "pectoral cavity blood vessel" EXACT []
is_a: UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0003520
name: pelvis blood vessel
def: "A blood vessel that is part of a pelvis [Automatically generated definition]." []
synonym: "blood vessel of pelvis" EXACT []
is_a: UBERON:0003835 ! abdominal segment blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0003521
name: pes blood vessel
def: "A blood vessel that is part of a foot [Automatically generated definition]." []
synonym: "autopod of hind limb blood vessel" EXACT []
synonym: "autopod of hindlimb blood vessel" EXACT []
synonym: "autopod of inferior member blood vessel" EXACT []
synonym: "autopod of lower extremity blood vessel" EXACT []
synonym: "blood vessel of autopod of hind limb" EXACT []
synonym: "blood vessel of autopod of hindlimb" EXACT []
synonym: "blood vessel of autopod of inferior member" EXACT []
synonym: "blood vessel of autopod of lower extremity" EXACT []
synonym: "blood vessel of distal free limb segment of hind limb" EXACT []
synonym: "blood vessel of distal free limb segment of hindlimb" EXACT []
synonym: "blood vessel of distal free limb segment of inferior member" EXACT []
synonym: "blood vessel of distal free limb segment of lower extremity" EXACT []
synonym: "blood vessel of foot" EXACT []
synonym: "blood vessel of hind limb autopod" EXACT []
synonym: "blood vessel of hind limb distal free limb segment" EXACT []
synonym: "blood vessel of hindlimb autopod" EXACT []
synonym: "blood vessel of hindlimb distal free limb segment" EXACT []
synonym: "blood vessel of inferior member autopod" EXACT []
synonym: "blood vessel of inferior member distal free limb segment" EXACT []
synonym: "blood vessel of lower extremity autopod" EXACT []
synonym: "blood vessel of lower extremity distal free limb segment" EXACT []
synonym: "blood vessel of terminal segment of free lower limb" EXACT []
synonym: "distal free limb segment of hind limb blood vessel" EXACT []
synonym: "distal free limb segment of hindlimb blood vessel" EXACT []
synonym: "distal free limb segment of inferior member blood vessel" EXACT []
synonym: "distal free limb segment of lower extremity blood vessel" EXACT []
synonym: "foot blood vessel" EXACT []
synonym: "hind limb autopod blood vessel" EXACT []
synonym: "hind limb distal free limb segment blood vessel" EXACT []
synonym: "hindlimb autopod blood vessel" EXACT []
synonym: "hindlimb distal free limb segment blood vessel" EXACT []
synonym: "inferior member autopod blood vessel" EXACT []
synonym: "inferior member distal free limb segment blood vessel" EXACT []
synonym: "lower extremity autopod blood vessel" EXACT []
synonym: "lower extremity distal free limb segment blood vessel" EXACT []
synonym: "terminal segment of free lower limb blood vessel" EXACT []
is_a: UBERON:0003516 ! hindlimb blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0003522
name: manual digit blood vessel
def: "A blood vessel that is part of a finger [Automatically generated definition]." []
synonym: "blood vessel of digit of hand" EXACT []
synonym: "blood vessel of digit of terminal segment of free upper limb" EXACT []
synonym: "blood vessel of digitus manus" EXACT []
synonym: "blood vessel of finger" EXACT []
synonym: "blood vessel of hand digit" EXACT []
synonym: "blood vessel of terminal segment of free upper limb digit" EXACT []
synonym: "digit of hand blood vessel" EXACT []
synonym: "digit of terminal segment of free upper limb blood vessel" EXACT []
synonym: "digitus manus blood vessel" EXACT []
synonym: "finger blood vessel" EXACT []
synonym: "fore limb digit blood vessel" EXACT []
synonym: "hand digit blood vessel" EXACT []
synonym: "hand digit blood vessel" NARROW []
synonym: "terminal segment of free upper limb digit blood vessel" EXACT []
is_a: UBERON:0003523 ! manus blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0003523
name: manus blood vessel
def: "A blood vessel that is part of a manus [Automatically generated definition]." []
synonym: "arm autopod blood vessel" EXACT []
synonym: "arm distal free limb segment blood vessel" EXACT []
synonym: "autopod of arm blood vessel" EXACT []
synonym: "autopod of brachial region blood vessel" EXACT []
synonym: "autopod of proximal segment of free upper limb blood vessel" EXACT []
synonym: "blood vessel of arm autopod" EXACT []
synonym: "blood vessel of arm distal free limb segment" EXACT []
synonym: "blood vessel of autopod of arm" EXACT []
synonym: "blood vessel of autopod of brachial region" EXACT []
synonym: "blood vessel of autopod of proximal segment of free upper limb" EXACT []
synonym: "blood vessel of brachial region autopod" EXACT []
synonym: "blood vessel of brachial region distal free limb segment" EXACT []
synonym: "blood vessel of distal free limb segment of arm" EXACT []
synonym: "blood vessel of distal free limb segment of brachial region" EXACT []
synonym: "blood vessel of distal free limb segment of proximal segment of free upper limb" EXACT []
synonym: "blood vessel of manus" EXACT []
synonym: "blood vessel of proximal segment of free upper limb autopod" EXACT []
synonym: "blood vessel of proximal segment of free upper limb distal free limb segment" EXACT []
synonym: "blood vessel of terminal segment of free upper limb" EXACT []
synonym: "brachial region autopod blood vessel" EXACT []
synonym: "brachial region distal free limb segment blood vessel" EXACT []
synonym: "distal free limb segment of arm blood vessel" EXACT []
synonym: "distal free limb segment of brachial region blood vessel" EXACT []
synonym: "distal free limb segment of proximal segment of free upper limb blood vessel" EXACT []
synonym: "hand blood vessel" EXACT []
synonym: "proximal segment of free upper limb autopod blood vessel" EXACT []
synonym: "proximal segment of free upper limb distal free limb segment blood vessel" EXACT []
synonym: "terminal segment of free upper limb blood vessel" EXACT []
is_a: UBERON:0003515 ! forelimb blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0003526
name: respiratory system capillary
def: "A capillary that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius blood capillary" EXACT []
synonym: "apparatus respiratorius capillary" EXACT []
synonym: "apparatus respiratorius capillary vessel" EXACT []
synonym: "blood capillary of apparatus respiratorius" EXACT []
synonym: "blood capillary of respiratory system" EXACT []
synonym: "capillary of apparatus respiratorius" EXACT []
synonym: "capillary of respiratory system" EXACT []
synonym: "capillary vessel of apparatus respiratorius" EXACT []
synonym: "capillary vessel of respiratory system" EXACT []
synonym: "respiratory system blood capillary" EXACT []
synonym: "respiratory system capillary vessel" EXACT []
is_a: UBERON:0001982 ! capillary
is_a: UBERON:0003504 ! respiratory system blood vessel
intersection_of: UBERON:0001982 ! capillary
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003527
name: kidney capillary
def: "A capillary that is part of a kidney [Automatically generated definition]." []
synonym: "blood capillary of kidney" EXACT []
synonym: "capillary of kidney" EXACT []
synonym: "capillary vessel of kidney" EXACT []
synonym: "kidney blood capillary" EXACT []
synonym: "kidney capillary vessel" EXACT []
synonym: "renal capillary" EXACT []
is_a: UBERON:0001982 ! capillary
is_a: UBERON:0003517 ! kidney blood vessel
intersection_of: UBERON:0001982 ! capillary
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0006544 ! kidney vasculature

[Term]
id: UBERON:0003528
name: brain gray matter
def: "A gray matter that is part of a brain [Automatically generated definition]." []
synonym: "brain grey matter" EXACT []
synonym: "brain grey substance" EXACT []
synonym: "gray matter of brain" EXACT []
synonym: "grey matter of brain" EXACT []
synonym: "grey substance of brain" EXACT []
is_a: UBERON:0002020 ! gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0003529
name: respiratory system lymphatic vessel endothelium
def: "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius endothelium of lymph vessel" EXACT []
synonym: "apparatus respiratorius lymph vessel endothelium" EXACT []
synonym: "apparatus respiratorius lymphatic vessel endothelium" EXACT []
synonym: "endothelium of lymph vessel of apparatus respiratorius" EXACT []
synonym: "endothelium of lymph vessel of respiratory system" EXACT []
synonym: "lymph vessel endothelium of apparatus respiratorius" EXACT []
synonym: "lymph vessel endothelium of respiratory system" EXACT []
synonym: "lymphatic vessel endothelium of apparatus respiratorius" EXACT []
synonym: "lymphatic vessel endothelium of respiratory system" EXACT []
synonym: "respiratory system endothelium of lymph vessel" EXACT []
synonym: "respiratory system lymph vessel endothelium" EXACT []
synonym: "respiratory system lymphatic vessel endothelium" EXACT []
is_a: UBERON:0002042 ! lymphatic vessel endothelium
is_a: UBERON:0004807 ! respiratory system epithelium
intersection_of: UBERON:0002042 ! lymphatic vessel endothelium
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel

[Term]
id: UBERON:0003530
name: pedal digit skin
def: "A zone of skin that is part of a toe [Automatically generated definition]." []
synonym: "digit of foot skin" EXACT []
synonym: "digit of terminal segment of free lower limb skin" EXACT []
synonym: "digitus pedis skin" EXACT []
synonym: "foot digit skin" EXACT []
synonym: "foot digit skin" NARROW []
synonym: "hind limb digit skin" EXACT []
synonym: "skin of digit of foot" EXACT []
synonym: "skin of digit of terminal segment of free lower limb" EXACT []
synonym: "skin of digitus pedis" EXACT []
synonym: "skin of foot digit" EXACT []
synonym: "skin of terminal segment of free lower limb digit" EXACT []
synonym: "skin of toe" EXACT []
synonym: "terminal segment of free lower limb digit skin" EXACT []
synonym: "toe skin" EXACT []
is_a: UBERON:0001513 ! skin of pes
is_a: UBERON:0015249 ! digit skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0003531
name: forelimb skin
def: "A zone of skin that is part of a forelimb [Automatically generated definition]." []
synonym: "anteriormost limb skin" EXACT []
synonym: "fore limb skin" EXACT []
synonym: "skin of anteriormost limb" EXACT []
synonym: "skin of fore limb" EXACT []
synonym: "skin of forelimb" EXACT []
synonym: "skin of superior member" EXACT []
synonym: "skin of upper extremity" EXACT []
synonym: "skin of upper limb" EXACT []
synonym: "superior member skin" EXACT []
synonym: "upper extremity skin" EXACT []
synonym: "upper limb skin" EXACT []
synonym: "wing skin" NARROW []
is_a: UBERON:0001419 ! skin of limb
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003532
name: hindlimb skin
def: "A zone of skin that is part of a hindlimb [Automatically generated definition]." []
synonym: "hind limb skin" EXACT []
synonym: "inferior member skin" EXACT []
synonym: "lower extremity skin" EXACT []
synonym: "lower limb skin" EXACT []
synonym: "skin of hind limb" EXACT []
synonym: "skin of hindlimb" EXACT []
synonym: "skin of inferior member" EXACT []
synonym: "skin of lower extremity" EXACT []
synonym: "skin of lower limb" EXACT []
is_a: UBERON:0001419 ! skin of limb
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003533
name: manual digit skin
def: "A zone of skin that is part of a finger [Automatically generated definition]." []
synonym: "digit of hand skin" EXACT []
synonym: "digit of terminal segment of free upper limb skin" EXACT []
synonym: "digitus manus skin" EXACT []
synonym: "finger skin" EXACT []
synonym: "fore limb digit skin" EXACT []
synonym: "hand digit skin" EXACT []
synonym: "hand digit skin" NARROW []
synonym: "skin of digit of hand" EXACT []
synonym: "skin of digit of terminal segment of free upper limb" EXACT []
synonym: "skin of digitus manus" EXACT []
synonym: "skin of finger" EXACT []
synonym: "skin of hand digit" EXACT []
synonym: "skin of terminal segment of free upper limb digit" EXACT []
synonym: "terminal segment of free upper limb digit skin" EXACT []
is_a: UBERON:0001519 ! skin of manus
is_a: UBERON:0015249 ! digit skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0003538
name: right lung bronchiole
def: "A bronchiole that is part of a right lung [Automatically generated definition]." []
synonym: "bronchiole of right lung" EXACT []
synonym: "lobular bronchiole of right lung" EXACT []
synonym: "right lung lobular bronchiole" EXACT []
is_a: UBERON:0002186 ! bronchiole
intersection_of: UBERON:0002186 ! bronchiole
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0003539
name: left lung bronchiole
def: "A bronchiole that is part of a left lung [Automatically generated definition]." []
synonym: "bronchiole of left lung" EXACT []
synonym: "left lung lobular bronchiole" EXACT []
synonym: "lobular bronchiole of left lung" EXACT []
is_a: UBERON:0002186 ! bronchiole
intersection_of: UBERON:0002186 ! bronchiole
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0003540
name: right lung terminal bronchiole
def: "A terminal bronchiole that is part of a right lung [Automatically generated definition]." []
synonym: "bronchiolus terminalis of right lung" EXACT []
synonym: "right lung bronchiolus terminalis" EXACT []
synonym: "terminal bronchiole of right lung" EXACT []
is_a: UBERON:0002187 ! terminal bronchiole
is_a: UBERON:0003538 ! right lung bronchiole
intersection_of: UBERON:0002187 ! terminal bronchiole
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0003541
name: left lung terminal bronchiole
def: "A terminal bronchiole that is part of a left lung [Automatically generated definition]." []
synonym: "bronchiolus terminalis of left lung" EXACT []
synonym: "left lung bronchiolus terminalis" EXACT []
synonym: "terminal bronchiole of left lung" EXACT []
is_a: UBERON:0002187 ! terminal bronchiole
is_a: UBERON:0003539 ! left lung bronchiole
intersection_of: UBERON:0002187 ! terminal bronchiole
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0003542
name: right lung respiratory bronchiole
def: "A respiratory bronchiole that is part of a right lung [Automatically generated definition]." []
synonym: "bronchiolus respiratorius of right lung" EXACT []
synonym: "respiratory bronchiole of right lung" EXACT []
synonym: "right lung bronchiolus respiratorius" EXACT []
is_a: UBERON:0002188 ! respiratory bronchiole
is_a: UBERON:0003538 ! right lung bronchiole
intersection_of: UBERON:0002188 ! respiratory bronchiole
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0003543
name: left lung respiratory bronchiole
def: "A respiratory bronchiole that is part of a left lung [Automatically generated definition]." []
synonym: "bronchiolus respiratorius of left lung" EXACT []
synonym: "left lung bronchiolus respiratorius" EXACT []
synonym: "respiratory bronchiole of left lung" EXACT []
is_a: UBERON:0002188 ! respiratory bronchiole
is_a: UBERON:0003539 ! left lung bronchiole
intersection_of: UBERON:0002188 ! respiratory bronchiole
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0003544
name: brain white matter
def: "The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." []
synonym: "brain white matter of neuraxis" EXACT []
synonym: "brain white substance" EXACT []
synonym: "white matter of brain" EXACT []
synonym: "white matter of neuraxis of brain" EXACT []
synonym: "white substance of brain" EXACT []
is_a: UBERON:0002316 ! white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0003546
name: distal convoluted tubule macula densa
def: "A macula densa that is part of a distal convoluted tubule [Automatically generated definition]." []
is_a: UBERON:0002335 ! macula densa
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0002335 ! macula densa
intersection_of: part_of UBERON:0001292 ! distal convoluted tubule
relationship: part_of UBERON:0001292 ! distal convoluted tubule
relationship: part_of UBERON:0002335 ! macula densa

[Term]
id: UBERON:0003547
name: brain meninx
def: "A meninx that is part of a brain [Automatically generated definition]." []
synonym: "brain meninges" EXACT []
synonym: "meninges of brain" EXACT []
synonym: "meninx of brain" EXACT []
is_a: UBERON:0002360 ! meninx
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0003548
name: forebrain meninges
def: "A meninx that is part of a forebrain [Automatically generated definition]." []
synonym: "forebrain meninx" EXACT []
synonym: "meninges of forebrain" EXACT []
synonym: "meninx of forebrain" EXACT []
is_a: UBERON:0003547 ! brain meninx
intersection_of: UBERON:0002360 ! meninx
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0003561
name: forebrain dura mater
def: "A dura mater that is part of a forebrain." []
synonym: "dura mater of forebrain" EXACT []
synonym: "dura mater of neuraxis of forebrain" EXACT []
synonym: "forebrain dura mater of neuraxis" EXACT []
is_a: UBERON:0002092 ! brain dura mater
is_a: UBERON:0003548 ! forebrain meninges
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0003562
name: midbrain dura mater
def: "A dura mater that is part of a midbrain [Automatically generated definition]." []
synonym: "dura mater of midbrain" EXACT []
synonym: "dura mater of neuraxis of midbrain" EXACT []
synonym: "mesencephalon dura mater" RELATED []
synonym: "midbrain dura mater of neuraxis" EXACT []
is_a: UBERON:0002092 ! brain dura mater
is_a: UBERON:0003288 ! meninx of midbrain
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain

[Term]
id: UBERON:0003563
name: telencephalon dura mater
def: "A dura mater that is part of a telencephalon [Automatically generated definition]." []
synonym: "dura mater of neuraxis of telencephalon" EXACT []
synonym: "dura mater of telencephalon" EXACT []
synonym: "telencephalon dura mater of neuraxis" EXACT []
is_a: UBERON:0003289 ! meninx of telencephalon
is_a: UBERON:0003561 ! forebrain dura mater
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0003564
name: diencephalon dura mater
def: "A dura mater that is part of a diencephalon [Automatically generated definition]." []
synonym: "between brain dura mater" EXACT []
synonym: "between brain dura mater of neuraxis" EXACT []
synonym: "diencephalon dura mater of neuraxis" EXACT []
synonym: "dura mater of between brain" EXACT []
synonym: "dura mater of diencephalon" EXACT []
synonym: "dura mater of interbrain" EXACT []
synonym: "dura mater of mature diencephalon" EXACT []
synonym: "dura mater of neuraxis of between brain" EXACT []
synonym: "dura mater of neuraxis of diencephalon" EXACT []
synonym: "dura mater of neuraxis of interbrain" EXACT []
synonym: "dura mater of neuraxis of mature diencephalon" EXACT []
synonym: "interbrain dura mater" EXACT []
synonym: "interbrain dura mater of neuraxis" EXACT []
synonym: "mature diencephalon dura mater" EXACT []
synonym: "mature diencephalon dura mater of neuraxis" EXACT []
is_a: UBERON:0003290 ! meninx of diencephalon
is_a: UBERON:0003561 ! forebrain dura mater
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0003565
name: hindbrain dura mater
def: "A dura mater that is part of a hindbrain [Automatically generated definition]." []
synonym: "dura mater of hindbrain" EXACT []
synonym: "dura mater of neuraxis of hindbrain" EXACT []
synonym: "hindbrain dura mater of neuraxis" EXACT []
synonym: "rhombencephalon dura mater" RELATED []
is_a: UBERON:0002092 ! brain dura mater
is_a: UBERON:0003291 ! meninx of hindbrain
intersection_of: UBERON:0002363 ! dura mater
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0003566
name: head connective tissue
def: "A portion of connective tissue that is part of a head [Automatically generated definition]." []
synonym: "adult head connective tissue" EXACT []
synonym: "adult head portion of connective tissue" EXACT []
synonym: "adult head textus connectivus" EXACT []
synonym: "connective tissue of adult head" EXACT []
synonym: "connective tissue of head" EXACT []
synonym: "head portion of connective tissue" EXACT []
synonym: "head textus connectivus" EXACT []
synonym: "portion of connective tissue of adult head" EXACT []
synonym: "portion of connective tissue of head" EXACT []
synonym: "textus connectivus of adult head" EXACT []
synonym: "textus connectivus of head" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0003567
name: abdomen connective tissue
def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." []
synonym: "abdomen portion of connective tissue" EXACT []
synonym: "abdomen textus connectivus" EXACT []
synonym: "connective tissue of abdomen" EXACT []
synonym: "portion of connective tissue of abdomen" EXACT []
synonym: "textus connectivus of abdomen" EXACT []
is_a: UBERON:0003838 ! abdominal segment connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0003569
name: leg connective tissue
def: "A portion of connective tissue that is part of a leg [Automatically generated definition]." []
synonym: "connective tissue of leg" EXACT []
synonym: "leg portion of connective tissue" EXACT []
synonym: "leg textus connectivus" EXACT []
synonym: "portion of connective tissue of leg" EXACT []
synonym: "textus connectivus of leg" EXACT []
is_a: UBERON:0003589 ! hindlimb connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0003570
name: respiratory system connective tissue
def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius connective tissue" EXACT []
synonym: "apparatus respiratorius portion of connective tissue" EXACT []
synonym: "apparatus respiratorius textus connectivus" EXACT []
synonym: "connective tissue of apparatus respiratorius" EXACT []
synonym: "connective tissue of respiratory system" EXACT []
synonym: "portion of connective tissue of apparatus respiratorius" EXACT []
synonym: "portion of connective tissue of respiratory system" EXACT []
synonym: "respiratory system portion of connective tissue" EXACT []
synonym: "respiratory system textus connectivus" EXACT []
synonym: "textus connectivus of apparatus respiratorius" EXACT []
synonym: "textus connectivus of respiratory system" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003571
name: trachea connective tissue
def: "A portion of connective tissue that is part of a trachea." []
synonym: "connective tissue of trachea" EXACT []
synonym: "connective tissue of windpipe" EXACT []
is_a: UBERON:0003580 ! lower respiratory tract connective tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003572
name: chest connective tissue
def: "A portion of connective tissue that is part of a chest [Automatically generated definition]." []
synonym: "anterior thoracic region connective tissue" EXACT []
synonym: "anterior thoracic region portion of connective tissue" EXACT []
synonym: "anterior thoracic region textus connectivus" EXACT []
synonym: "anterolateral part of thorax connective tissue" EXACT []
synonym: "anterolateral part of thorax portion of connective tissue" EXACT []
synonym: "anterolateral part of thorax textus connectivus" EXACT []
synonym: "chest portion of connective tissue" EXACT []
synonym: "chest textus connectivus" EXACT []
synonym: "connective tissue of anterior thoracic region" EXACT []
synonym: "connective tissue of anterolateral part of thorax" EXACT []
synonym: "connective tissue of chest" EXACT []
synonym: "connective tissue of front of thorax" EXACT []
synonym: "front of thorax connective tissue" EXACT []
synonym: "front of thorax portion of connective tissue" EXACT []
synonym: "front of thorax textus connectivus" EXACT []
synonym: "portion of connective tissue of anterior thoracic region" EXACT []
synonym: "portion of connective tissue of anterolateral part of thorax" EXACT []
synonym: "portion of connective tissue of chest" EXACT []
synonym: "portion of connective tissue of front of thorax" EXACT []
synonym: "textus connectivus of anterior thoracic region" EXACT []
synonym: "textus connectivus of anterolateral part of thorax" EXACT []
synonym: "textus connectivus of chest" EXACT []
synonym: "textus connectivus of front of thorax" EXACT []
is_a: UBERON:0003837 ! thoracic segment connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0003573
name: arm connective tissue
def: "A portion of connective tissue that is part of an arm [Automatically generated definition]." []
synonym: "arm portion of connective tissue" EXACT []
synonym: "arm textus connectivus" EXACT []
synonym: "brachial region connective tissue" EXACT []
synonym: "brachial region portion of connective tissue" EXACT []
synonym: "brachial region textus connectivus" EXACT []
synonym: "connective tissue of arm" EXACT []
synonym: "connective tissue of brachial region" EXACT []
synonym: "connective tissue of proximal segment of free upper limb" EXACT []
synonym: "portion of connective tissue of arm" EXACT []
synonym: "portion of connective tissue of brachial region" EXACT []
synonym: "portion of connective tissue of proximal segment of free upper limb" EXACT []
synonym: "proximal segment of free upper limb connective tissue" EXACT []
synonym: "proximal segment of free upper limb portion of connective tissue" EXACT []
synonym: "proximal segment of free upper limb textus connectivus" EXACT []
synonym: "textus connectivus of arm" EXACT []
synonym: "textus connectivus of brachial region" EXACT []
synonym: "textus connectivus of proximal segment of free upper limb" EXACT []
is_a: UBERON:0003588 ! forelimb connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0003576
name: hip connective tissue
def: "A portion of connective tissue that is part of a hip [Automatically generated definition]." []
synonym: "connective tissue of hip" EXACT []
synonym: "connective tissue of hip region" EXACT []
synonym: "connective tissue of regio coxae" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001464 ! hip
relationship: part_of UBERON:0001464 ! hip

[Term]
id: UBERON:0003577
name: knee connective tissue
def: "A portion of connective tissue that is part of a knee [Automatically generated definition]." []
synonym: "connective tissue of knee" EXACT []
synonym: "knee portion of connective tissue" EXACT []
is_a: UBERON:0003569 ! leg connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001465 ! knee
relationship: part_of UBERON:0001465 ! knee

[Term]
id: UBERON:0003578
name: pedal digit connective tissue
def: "A portion of connective tissue that is part of a toe [Automatically generated definition]." []
synonym: "connective tissue of digit of foot" EXACT []
synonym: "connective tissue of digitus pedis" EXACT []
synonym: "connective tissue of foot digit" EXACT []
synonym: "connective tissue of toe" EXACT []
synonym: "digitus pedis textus connectivus" EXACT []
synonym: "foot digit connective tissue" EXACT []
synonym: "foot digit connective tissue" NARROW []
synonym: "hind limb digit connective tissue" EXACT []
is_a: UBERON:0003595 ! pes connective tissue
is_a: UBERON:0015791 ! digit connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0003579
name: shoulder connective tissue
def: "A portion of connective tissue that is part of a shoulder [Automatically generated definition]." []
synonym: "connective tissue of shoulder" EXACT []
synonym: "portion of connective tissue of shoulder" EXACT []
synonym: "shoulder portion of connective tissue" EXACT []
synonym: "shoulder textus connectivus" EXACT []
synonym: "textus connectivus of shoulder" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0003580
name: lower respiratory tract connective tissue
def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." []
synonym: "connective tissue of lower respiratory tract" EXACT []
synonym: "lower respiratory tract portion of connective tissue" EXACT []
synonym: "lower respiratory tract textus connectivus" EXACT []
synonym: "portion of connective tissue of lower respiratory tract" EXACT []
synonym: "textus connectivus of lower respiratory tract" EXACT []
is_a: UBERON:0003570 ! respiratory system connective tissue
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0003581
name: eyelid connective tissue
def: "A portion of connective tissue that is part of a eyelid [Automatically generated definition]." []
synonym: "blepharon connective tissue" EXACT []
synonym: "connective tissue of blepharon" EXACT []
synonym: "connective tissue of eyelid" EXACT []
is_a: UBERON:0003566 ! head connective tissue
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0003582
name: nasopharynx connective tissue
def: "A portion of connective tissue that is part of a nasopharynx [Automatically generated definition]." []
synonym: "connective tissue of nasal part of pharynx" EXACT []
synonym: "connective tissue of nasopharynx" EXACT []
synonym: "connective tissue of rhinopharynx" EXACT []
synonym: "nasal part of pharynx connective tissue" EXACT []
synonym: "nasal part of pharynx portion of connective tissue" EXACT []
synonym: "nasal part of pharynx textus connectivus" EXACT []
synonym: "nasopharynx portion of connective tissue" EXACT []
synonym: "nasopharynx textus connectivus" EXACT []
synonym: "portion of connective tissue of nasal part of pharynx" EXACT []
synonym: "portion of connective tissue of nasopharynx" EXACT []
synonym: "portion of connective tissue of rhinopharynx" EXACT []
synonym: "rhinopharynx connective tissue" EXACT []
synonym: "rhinopharynx portion of connective tissue" EXACT []
synonym: "rhinopharynx textus connectivus" EXACT []
synonym: "textus connectivus of nasal part of pharynx" EXACT []
synonym: "textus connectivus of nasopharynx" EXACT []
synonym: "textus connectivus of rhinopharynx" EXACT []
is_a: UBERON:0003570 ! respiratory system connective tissue
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx

[Term]
id: UBERON:0003584
name: mammary gland connective tissue
def: "The fibrous supportive tissue of the mammary gland." []
synonym: "connective tissue of lactiferous gland" EXACT []
synonym: "connective tissue of lobe of breast" EXACT []
synonym: "connective tissue of lobe of mammary gland" EXACT []
synonym: "connective tissue of mammary gland" EXACT []
synonym: "lactiferous gland connective tissue" EXACT []
synonym: "lactiferous gland portion of connective tissue" EXACT []
synonym: "lactiferous gland stroma" EXACT []
synonym: "mammary gland stroma" EXACT []
synonym: "mammary stroma" EXACT []
synonym: "stroma of lactiferous gland" EXACT []
is_a: UBERON:0002384 ! connective tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0003585
name: dermis connective tissue
def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." []
synonym: "connective tissue of dermis" EXACT []
synonym: "dermis portion of connective tissue" EXACT []
synonym: "dermis textus connectivus" EXACT []
synonym: "portion of connective tissue of dermis" EXACT []
synonym: "textus connectivus of dermis" EXACT []
is_a: UBERON:0002384 ! connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002067 ! dermis
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0004016 ! dermatome
relationship: part_of UBERON:0002067 ! dermis

[Term]
id: UBERON:0003586
name: trunk connective tissue
def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." []
synonym: "connective tissue of torso" EXACT []
synonym: "connective tissue of trunk" EXACT []
synonym: "portion of connective tissue of torso" EXACT []
synonym: "portion of connective tissue of trunk" EXACT []
synonym: "textus connectivus of torso" EXACT []
synonym: "textus connectivus of trunk" EXACT []
synonym: "torso connective tissue" EXACT []
synonym: "torso portion of connective tissue" EXACT []
synonym: "torso textus connectivus" EXACT []
synonym: "trunk portion of connective tissue" EXACT []
synonym: "trunk textus connectivus" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0003587
name: limb connective tissue
def: "A portion of connective tissue that is part of a limb [Automatically generated definition]." []
synonym: "connective tissue of limb" EXACT []
synonym: "limb portion of connective tissue" EXACT []
synonym: "limb textus connectivus" EXACT []
synonym: "portion of connective tissue of limb" EXACT []
synonym: "textus connectivus of limb" EXACT []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0003588
name: forelimb connective tissue
def: "A portion of connective tissue that is part of a forelimb [Automatically generated definition]." []
synonym: "connective tissue of anteriormost limb" EXACT []
synonym: "connective tissue of fore limb" EXACT []
synonym: "connective tissue of forelimb" EXACT []
synonym: "connective tissue of superior member" EXACT []
synonym: "connective tissue of upper extremity" EXACT []
synonym: "wing connective tissue" NARROW []
is_a: UBERON:0003587 ! limb connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003589
name: hindlimb connective tissue
def: "A portion of connective tissue that is part of a hindlimb [Automatically generated definition]." []
synonym: "connective tissue of hind limb" EXACT []
synonym: "connective tissue of hindlimb" EXACT []
synonym: "connective tissue of inferior member" EXACT []
synonym: "connective tissue of lower extremity" EXACT []
synonym: "hind limb connective tissue" EXACT []
is_a: UBERON:0003587 ! limb connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003592
name: bronchus connective tissue
def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi connective tissue" EXACT []
synonym: "bronchi portion of connective tissue" EXACT []
synonym: "bronchi textus connectivus" EXACT []
synonym: "bronchial connective tissue" RELATED []
synonym: "bronchial mesenchyme" RELATED []
synonym: "bronchial trunk connective tissue" EXACT []
synonym: "bronchial trunk portion of connective tissue" EXACT []
synonym: "bronchial trunk textus connectivus" EXACT []
synonym: "bronchus portion of connective tissue" EXACT []
synonym: "bronchus textus connectivus" EXACT []
synonym: "connective tissue of bronchi" EXACT []
synonym: "connective tissue of bronchial trunk" EXACT []
synonym: "connective tissue of bronchus" EXACT []
synonym: "portion of connective tissue of bronchi" EXACT []
synonym: "portion of connective tissue of bronchial trunk" EXACT []
synonym: "portion of connective tissue of bronchus" EXACT []
synonym: "textus connectivus of bronchi" EXACT []
synonym: "textus connectivus of bronchial trunk" EXACT []
synonym: "textus connectivus of bronchus" EXACT []
is_a: UBERON:0003580 ! lower respiratory tract connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0003594
name: pelvis connective tissue
def: "A portion of connective tissue that is part of a pelvis [Automatically generated definition]." []
synonym: "connective tissue of pelvis" EXACT []
synonym: "pelvis portion of connective tissue" EXACT []
synonym: "pelvis textus connectivus" EXACT []
synonym: "portion of connective tissue of pelvis" EXACT []
synonym: "textus connectivus of pelvis" EXACT []
is_a: UBERON:0003838 ! abdominal segment connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0003595
name: pes connective tissue
def: "A portion of connective tissue that is part of a foot [Automatically generated definition]." []
synonym: "connective tissue of foot" EXACT []
synonym: "connective tissue of terminal segment of free lower limb" EXACT []
synonym: "foot connective tissue" EXACT []
synonym: "textus connectivus of pes" EXACT []
is_a: UBERON:0003589 ! hindlimb connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0003597
name: manual digit connective tissue
def: "A portion of connective tissue that is part of a finger [Automatically generated definition]." []
synonym: "connective tissue of digit of hand" EXACT []
synonym: "connective tissue of digitus manus" EXACT []
synonym: "connective tissue of finger" EXACT []
synonym: "connective tissue of hand digit" EXACT []
synonym: "fore limb digit connective tissue" EXACT []
synonym: "hand digit connective tissue" EXACT []
synonym: "hand digit connective tissue" NARROW []
is_a: UBERON:0003598 ! manus connective tissue
is_a: UBERON:0015791 ! digit connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0003598
name: manus connective tissue
def: "A portion of connective tissue that is part of a hand [Automatically generated definition]." []
synonym: "connective tissue of hand" EXACT []
synonym: "connective tissue of terminal segment of free upper limb" EXACT []
synonym: "hand connective tissue" EXACT []
is_a: UBERON:0003588 ! forelimb connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0003603
name: lower respiratory tract cartilage
def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." []
synonym: "cartilage of lower respiratory tract" EXACT []
is_a: UBERON:0003406 ! cartilage of respiratory system
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0003604
name: trachea cartilage
def: "the ring-shaped cartilaginous structures that support the trachea" []
synonym: "cartilage of the trachea" RELATED []
synonym: "cartilage of trachea" EXACT []
synonym: "cartilage of windpipe" EXACT []
synonym: "cartilagines tracheales" RELATED []
synonym: "cartilaginous ring of trachea" EXACT []
synonym: "cartilaginous trachea cartilage" EXACT []
synonym: "cartilago trachealis" EXACT []
synonym: "ring of the trachea" RELATED []
synonym: "trachea ring" RELATED []
synonym: "tracheal cartilage" EXACT []
synonym: "tracheal ring" RELATED []
synonym: "windpipe cartilage" EXACT []
is_a: UBERON:0003603 ! lower respiratory tract cartilage
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from UBERON:0007267 ! trachea pre-cartilage rings
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003605
name: eye skin gland
def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." []
synonym: "camera-type eye skin gland" EXACT []
synonym: "camera-type eye skin glands" EXACT []
synonym: "camera-type eye skin glands set" EXACT []
synonym: "skin gland of camera-type eye" EXACT []
synonym: "skin gland of vertebrate eye" EXACT []
synonym: "skin glands of camera-type eye" EXACT []
synonym: "skin glands of vertebrate eye" EXACT []
synonym: "skin glands set of camera-type eye" EXACT []
synonym: "skin glands set of vertebrate eye" EXACT []
synonym: "vertebrate eye skin gland" EXACT []
synonym: "vertebrate eye skin glands" EXACT []
synonym: "vertebrate eye skin glands set" EXACT []
is_a: UBERON:0002419 ! skin gland
is_a: UBERON:0004859 ! eye gland
is_a: UBERON:0015152 ! gland of ocular region
intersection_of: UBERON:0002419 ! skin gland
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0003606
name: limb long bone
def: "A long bone that is part of a limb [Automatically generated definition]." []
synonym: "long bone of limb" EXACT []
is_a: UBERON:0002428 ! limb bone
is_a: UBERON:0002495 ! long bone
intersection_of: UBERON:0002495 ! long bone
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0003607
name: forelimb long bone
def: "A long bone that is part of a forelimb [Automatically generated definition]." []
synonym: "anteriormost limb long bone" EXACT []
synonym: "fore limb long bone" EXACT []
synonym: "long bone of anteriormost limb" EXACT []
synonym: "long bone of fore limb" EXACT []
synonym: "long bone of forelimb" EXACT []
synonym: "long bone of superior member" EXACT []
synonym: "long bone of upper extremity" EXACT []
synonym: "superior member long bone" EXACT []
synonym: "upper extremity long bone" EXACT []
synonym: "wing long bone" NARROW []
is_a: UBERON:0003606 ! limb long bone
is_a: UBERON:0008962 ! forelimb bone
intersection_of: UBERON:0002495 ! long bone
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003608
name: hindlimb long bone
def: "A long bone that is part of a hindlimb [Automatically generated definition]." []
synonym: "hind limb long bone" EXACT []
synonym: "inferior member long bone" EXACT []
synonym: "long bone of hind limb" EXACT []
synonym: "long bone of hindlimb" EXACT []
synonym: "long bone of inferior member" EXACT []
synonym: "long bone of lower extremity" EXACT []
synonym: "lower extremity long bone" EXACT []
is_a: UBERON:0003464 ! hindlimb bone
is_a: UBERON:0003606 ! limb long bone
intersection_of: UBERON:0002495 ! long bone
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003609
name: aorta elastic tissue
def: "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." []
synonym: "adult aorta elastic connective tissue" EXACT []
synonym: "adult aorta elastic tissue" EXACT []
synonym: "adult aorta textus connectivus elasticus" EXACT []
synonym: "aorta elastic connective tissue" EXACT []
synonym: "aorta elastic lamina" EXACT []
synonym: "aorta elastic laminae" EXACT []
synonym: "aorta textus connectivus elasticus" EXACT []
synonym: "dorsal aorta elastic connective tissue" EXACT []
synonym: "dorsal aorta elastic tissue" EXACT []
synonym: "dorsal aorta textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of adult aorta" EXACT []
synonym: "elastic connective tissue of aorta" EXACT []
synonym: "elastic connective tissue of dorsal aorta" EXACT []
synonym: "elastic connective tissue of trunk of aortic tree" EXACT []
synonym: "elastic tissue of adult aorta" EXACT []
synonym: "elastic tissue of aorta" EXACT []
synonym: "elastic tissue of dorsal aorta" EXACT []
synonym: "elastic tissue of trunk of aortic tree" EXACT []
synonym: "textus connectivus elasticus of adult aorta" EXACT []
synonym: "textus connectivus elasticus of aorta" EXACT []
synonym: "textus connectivus elasticus of dorsal aorta" EXACT []
synonym: "textus connectivus elasticus of trunk of aortic tree" EXACT []
synonym: "trunk of aortic tree elastic connective tissue" EXACT []
synonym: "trunk of aortic tree elastic tissue" EXACT []
synonym: "trunk of aortic tree textus connectivus elasticus" EXACT []
is_a: UBERON:0003614 ! blood vessel elastic tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0003610
name: heart elastic tissue
def: "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." []
synonym: "cardiac elastic tissue" EXACT []
synonym: "elastic connective tissue of heart" EXACT []
synonym: "elastic tissue of heart" EXACT []
synonym: "heart elastic connective tissue" EXACT []
synonym: "heart textus connectivus elasticus" EXACT []
synonym: "textus connectivus elasticus of heart" EXACT []
is_a: UBERON:0003613 ! cardiovascular system elastic tissue
is_a: UBERON:0003837 ! thoracic segment connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0003611
name: respiratory system elastic tissue
def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius elastic connective tissue" EXACT []
synonym: "apparatus respiratorius elastic tissue" EXACT []
synonym: "apparatus respiratorius textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of apparatus respiratorius" EXACT []
synonym: "elastic connective tissue of respiratory system" EXACT []
synonym: "elastic tissue of apparatus respiratorius" EXACT []
synonym: "elastic tissue of respiratory system" EXACT []
synonym: "respiratory system elastic connective tissue" EXACT []
synonym: "respiratory system textus connectivus elasticus" EXACT []
synonym: "textus connectivus elasticus of apparatus respiratorius" EXACT []
synonym: "textus connectivus elasticus of respiratory system" EXACT []
is_a: UBERON:0002521 ! elastic tissue
is_a: UBERON:0003570 ! respiratory system connective tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0004777 ! respiratory system submucosa

[Term]
id: UBERON:0003613
name: cardiovascular system elastic tissue
def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." []
synonym: "cardiovascular system elastic connective tissue" EXACT []
synonym: "cardiovascular system textus connectivus elasticus" EXACT []
synonym: "circulatory system elastic connective tissue" EXACT []
synonym: "circulatory system elastic tissue" EXACT []
synonym: "circulatory system textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of cardiovascular system" EXACT []
synonym: "elastic connective tissue of circulatory system" EXACT []
synonym: "elastic tissue of cardiovascular system" EXACT []
synonym: "elastic tissue of circulatory system" EXACT []
synonym: "textus connectivus elasticus of cardiovascular system" EXACT []
synonym: "textus connectivus elasticus of circulatory system" EXACT []
is_a: UBERON:0002521 ! elastic tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0001009 ! circulatory system
relationship: part_of UBERON:0001009 ! circulatory system
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0003614
name: blood vessel elastic tissue
def: "Elastic tissue layer that lines a blood vessel layer." []
synonym: "blood vessel elastic connective tissue" EXACT []
synonym: "blood vessel textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of blood vessel" EXACT []
synonym: "elastic lamina" BROAD []
synonym: "elastic laminae" BROAD []
synonym: "elastic tissue of blood vessel" EXACT []
synonym: "textus connectivus elasticus of blood vessel" EXACT []
synonym: "vascular elastic lamina" EXACT []
synonym: "vascular elastic laminae" EXACT []
synonym: "vascular elastic tissue" EXACT []
is_a: UBERON:0003613 ! cardiovascular system elastic tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0003615
name: lung elastic tissue
def: "Elastic tissue that is part of a lung [Automatically generated definition]." []
synonym: "elastic connective tissue of lung" EXACT []
synonym: "elastic tissue of lung" EXACT []
synonym: "lung elastic connective tissue" EXACT []
synonym: "lung textus connectivus elasticus" EXACT []
synonym: "pulmonary elastic fiber" NARROW []
synonym: "textus connectivus elasticus of lung" EXACT []
is_a: UBERON:0000114 ! lung connective tissue
is_a: UBERON:0003611 ! respiratory system elastic tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0003616
name: bronchus elastic tissue
def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi elastic connective tissue" EXACT []
synonym: "bronchi elastic tissue" EXACT []
synonym: "bronchi textus connectivus elasticus" EXACT []
synonym: "bronchial trunk elastic connective tissue" EXACT []
synonym: "bronchial trunk elastic tissue" EXACT []
synonym: "bronchial trunk textus connectivus elasticus" EXACT []
synonym: "bronchus elastic connective tissue" EXACT []
synonym: "bronchus textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of bronchi" EXACT []
synonym: "elastic connective tissue of bronchial trunk" EXACT []
synonym: "elastic connective tissue of bronchus" EXACT []
synonym: "elastic tissue of bronchi" EXACT []
synonym: "elastic tissue of bronchial trunk" EXACT []
synonym: "elastic tissue of bronchus" EXACT []
synonym: "textus connectivus elasticus of bronchi" EXACT []
synonym: "textus connectivus elasticus of bronchial trunk" EXACT []
synonym: "textus connectivus elasticus of bronchus" EXACT []
is_a: UBERON:0003592 ! bronchus connective tissue
is_a: UBERON:0003611 ! respiratory system elastic tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0001957 ! submucosa of bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0003617
name: trachea elastic tissue
def: "An elastic tissue that is part of a trachea [Automatically generated definition]." []
synonym: "cartilaginous trachea elastic connective tissue" EXACT []
synonym: "cartilaginous trachea elastic tissue" EXACT []
synonym: "cartilaginous trachea textus connectivus elasticus" EXACT []
synonym: "elastic connective tissue of cartilaginous trachea" EXACT []
synonym: "elastic connective tissue of vertebrate trachea" EXACT []
synonym: "elastic connective tissue of windpipe" EXACT []
synonym: "elastic tissue of cartilaginous trachea" EXACT []
synonym: "elastic tissue of vertebrate trachea" EXACT []
synonym: "elastic tissue of windpipe" EXACT []
synonym: "textus connectivus elasticus of cartilaginous trachea" EXACT []
synonym: "textus connectivus elasticus of vertebrate trachea" EXACT []
synonym: "textus connectivus elasticus of windpipe" EXACT []
synonym: "vertebrate trachea elastic connective tissue" EXACT []
synonym: "vertebrate trachea elastic tissue" EXACT []
synonym: "vertebrate trachea textus connectivus elasticus" EXACT []
synonym: "windpipe elastic connective tissue" EXACT []
synonym: "windpipe elastic tissue" EXACT []
synonym: "windpipe textus connectivus elasticus" EXACT []
is_a: UBERON:0003571 ! trachea connective tissue
is_a: UBERON:0003611 ! respiratory system elastic tissue
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0002202 ! submucosa of trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0003619
name: aorta tunica intima
def: "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." []
synonym: "adult aorta tunica intima" EXACT []
synonym: "dorsal aorta tunica intima" EXACT []
synonym: "trunk of aortic tree tunica intima" EXACT []
synonym: "tunica intima of adult aorta" EXACT []
synonym: "tunica intima of aorta" EXACT []
synonym: "tunica intima of dorsal aorta" EXACT []
synonym: "tunica intima of trunk of aortic tree" EXACT []
is_a: UBERON:0002523 ! tunica intima
is_a: UBERON:0004851 ! aorta endothelium
intersection_of: UBERON:0002523 ! tunica intima
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0004663 ! aorta wall

[Term]
id: UBERON:0003643
name: respiratory system arterial blood vessel
def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." []
is_a: UBERON:0003504 ! respiratory system blood vessel
is_a: UBERON:0003509 ! arterial blood vessel
intersection_of: UBERON:0003509 ! arterial blood vessel
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003644
name: kidney arterial blood vessel
def: "An arterial blood vessel that is part of a kidney [Automatically generated definition]." []
synonym: "kidney arterial system" RELATED []
is_a: UBERON:0003509 ! arterial blood vessel
is_a: UBERON:0003517 ! kidney blood vessel
intersection_of: UBERON:0003509 ! arterial blood vessel
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0003657
name: limb joint
def: "Any joint that is part of a (free) limb." []
synonym: "joint of limb" EXACT []
synonym: "joint of limb skeletal system" EXACT []
synonym: "skeletal limb joint" EXACT []
is_a: UBERON:0000982 ! skeletal joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0003658
name: hip muscle
def: "Any muscle organ that is part of a hip [Automatically generated definition]." []
synonym: "hip muscle organ" EXACT []
synonym: "hip region muscle organ" EXACT []
synonym: "muscle organ of hip" EXACT []
synonym: "muscle organ of hip region" EXACT []
synonym: "muscle organ of regio coxae" EXACT []
synonym: "regio coxae muscle organ" EXACT []
is_a: UBERON:0010890 ! pelvic complex muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001464 ! hip
relationship: part_of UBERON:0001464 ! hip
relationship: part_of UBERON:0004475 ! musculature of hip

[Term]
id: UBERON:0003659
name: pedal digit muscle
def: "Any muscle organ that is part of a toe [Automatically generated definition]." []
synonym: "digit of foot muscle organ" EXACT []
synonym: "digit of terminal segment of free lower limb muscle organ" EXACT []
synonym: "digitus pedis muscle organ" EXACT []
synonym: "foot digit muscle" EXACT []
synonym: "foot digit muscle" NARROW []
synonym: "foot digit muscle organ" EXACT []
synonym: "hind limb digit muscle" EXACT []
synonym: "muscle organ of digit of foot" EXACT []
synonym: "muscle organ of digit of terminal segment of free lower limb" EXACT []
synonym: "muscle organ of digitus pedis" EXACT []
synonym: "muscle organ of foot digit" EXACT []
synonym: "muscle organ of terminal segment of free lower limb digit" EXACT []
synonym: "muscle organ of toe" EXACT []
synonym: "terminal segment of free lower limb digit muscle organ" EXACT []
synonym: "toe muscle organ" EXACT []
is_a: UBERON:0001498 ! muscle of pes
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0003661
name: limb muscle
def: "Any muscle organ that is part of a limb [Automatically generated definition]." []
synonym: "limb muscle organ" EXACT []
synonym: "limb skeletal muscle" EXACT []
synonym: "muscle organ of limb" EXACT []
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0004480 ! musculature of limb

[Term]
id: UBERON:0003662
name: forelimb muscle
def: "Any muscle organ that is part of a forelimb." []
synonym: "arm muscle system" RELATED []
synonym: "fore limb muscle organ" EXACT []
synonym: "forelimb muscle organ" EXACT []
synonym: "free upper limb muscle" EXACT []
synonym: "muscle of free upper limb" EXACT []
synonym: "muscle of upper limb" EXACT []
synonym: "musculature of arm" RELATED []
synonym: "musculature of the arm" RELATED []
synonym: "upper limb skeletal muscle" EXACT []
synonym: "wing muscle" NARROW []
is_a: UBERON:0003661 ! limb muscle
is_a: UBERON:0014794 ! pectoral appendage muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0004481 ! musculature of upper limb

[Term]
id: UBERON:0003663
name: hindlimb muscle
def: "Any muscle organ that is part of a hindlimb [Automatically generated definition]." []
synonym: "free lower limb muscle" EXACT []
synonym: "hind limb muscle organ" EXACT []
synonym: "hindlimb muscle organ" EXACT []
synonym: "inferior member muscle organ" EXACT []
synonym: "lower extremity muscle organ" EXACT []
synonym: "lower limb skeletal muscle" EXACT []
synonym: "muscle of free lower limb" EXACT []
synonym: "muscle of posterior limb" EXACT []
synonym: "muscle organ of hind limb" EXACT []
synonym: "muscle organ of hindlimb" EXACT []
synonym: "muscle organ of inferior member" EXACT []
synonym: "muscle organ of lower extremity" EXACT []
is_a: UBERON:0003661 ! limb muscle
is_a: UBERON:0014795 ! pelvic appendage muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0004482 ! musculature of lower limb

[Term]
id: UBERON:0003664
name: manual digit muscle
def: "Any muscle organ that is part of a finger [Automatically generated definition]." []
synonym: "digit of hand muscle organ" EXACT []
synonym: "digit of terminal segment of free upper limb muscle organ" EXACT []
synonym: "digitus manus muscle organ" EXACT []
synonym: "finger muscle organ" EXACT []
synonym: "fore limb digit muscle" EXACT []
synonym: "hand digit muscle" EXACT []
synonym: "hand digit muscle" NARROW []
synonym: "hand digit muscle organ" EXACT []
synonym: "muscle organ of digit of hand" EXACT []
synonym: "muscle organ of digit of terminal segment of free upper limb" EXACT []
synonym: "muscle organ of digitus manus" EXACT []
synonym: "muscle organ of finger" EXACT []
synonym: "muscle organ of hand digit" EXACT []
synonym: "muscle organ of terminal segment of free upper limb digit" EXACT []
synonym: "terminal segment of free upper limb digit muscle organ" EXACT []
is_a: UBERON:0001500 ! muscle of manus
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0003672
name: dentition
def: "A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl." []
synonym: "collection of teeth" RELATED []
synonym: "dentes" EXACT []
synonym: "set of teeth" EXACT []
synonym: "teeth" EXACT []
synonym: "teeth" RELATED []
synonym: "teeth set" EXACT []
is_a: UBERON:0004288 ! skeleton
relationship: part_of UBERON:0010323 ! cranial skeletal system

[Term]
id: UBERON:0003685
name: cranial suture
def: "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." []
synonym: "cranium suture" EXACT []
synonym: "sutura" BROAD []
synonym: "suture" BROAD []
synonym: "suture joint of skull" EXACT []
synonym: "suture of cranium" EXACT []
is_a: UBERON:0002209 ! fibrous joint
is_a: UBERON:0009198 ! craniofacial suture
intersection_of: UBERON:0002209 ! fibrous joint
intersection_of: part_of UBERON:0003128 ! cranium
relationship: part_of UBERON:0003128 ! cranium

[Term]
id: UBERON:0003688
name: omentum
def: "A fold of peritoneum originating at the stomach and supporting the viscera." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0001178 ! visceral peritoneum

[Term]
id: UBERON:0003697
name: abdominal wall
def: "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." []
synonym: "abdominal wall proper" RELATED []
synonym: "layers of the abdominal wall" RELATED []
synonym: "paries abdominalis" EXACT []
synonym: "paries abdominalis" RELATED []
synonym: "wall of abdomen" EXACT []
synonym: "wall of abdomen proper" EXACT []
is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0003703
name: extrahepatic bile duct
def: "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." []
synonym: "bile duct extrahepatic part" RELATED []
synonym: "extrahepatic biliary system" RELATED []
is_a: UBERON:0002394 ! bile duct

[Term]
id: UBERON:0003704
name: intrahepatic bile duct
def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." []
synonym: "bile duct intrahepatic part" EXACT []
synonym: "intrahepatic biliary system" RELATED []
is_a: UBERON:0002394 ! bile duct
intersection_of: UBERON:0002394 ! bile duct
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0003729
name: mouth mucosa
def: "A mucous membrane that lines the mouth." []
synonym: "buccal mucosa" RELATED []
synonym: "mouth mucosa" EXACT []
synonym: "mouth mucous membrane" EXACT []
synonym: "mouth organ mucosa" EXACT []
synonym: "mucosa of mouth" EXACT []
synonym: "mucosal lining of mouth" RELATED []
synonym: "mucous membrane of mouth" EXACT []
synonym: "oral mucosa" RELATED []
synonym: "oral mucous membrane" EXACT []
synonym: "oral part of viscerocranial mucosa" EXACT []
synonym: "tunica mucosa oris" EXACT []
synonym: "tunica mucosa oris" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000344 ! mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000165 ! mouth
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0003820
name: prostate bud
def: "A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." []
synonym: "prostate ductal progenitor" EXACT []
synonym: "prostate gland bud" RELATED []
synonym: "prostate primordium" RELATED []
synonym: "prostatic bud" EXACT []
is_a: UBERON:0004902 ! urogenital sinus epithelium
is_a: UBERON:0005153 ! epithelial bud
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0009847 ! prostate field
relationship: part_of UBERON:0004902 ! urogenital sinus epithelium

[Term]
id: UBERON:0003822
name: forelimb stylopod
def: "The part of the forelimb between pectoral region and the elbow, corresponding to the humerus." []
synonym: "arm" RELATED []
synonym: "brachial region" EXACT []
synonym: "brachium" EXACT []
synonym: "fore propodium" EXACT []
synonym: "forelimb propodium" EXACT []
synonym: "forelimb stylopodial element" EXACT []
synonym: "forelimb stylopodium" EXACT []
synonym: "proximal segment of free upper limb" EXACT []
synonym: "regio brachialis" EXACT []
synonym: "stylopod of arm" EXACT []
synonym: "stylopod of forelimb" EXACT []
synonym: "upper arm" EXACT []
synonym: "wing stylopod" NARROW []
is_a: UBERON:0002472 ! stylopod
is_a: UBERON:0008785 ! upper limb segment
intersection_of: UBERON:0002472 ! stylopod
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003824
name: nerve of thoracic segment
def: "A nerve that is part of a thorax [Automatically generated definition]." []
synonym: "nerve of thorax" EXACT []
synonym: "thoracic segment nerve" EXACT []
synonym: "thorax nerve" EXACT []
synonym: "upper body nerve" RELATED []
is_a: UBERON:0003439 ! nerve of trunk region
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0003825
name: nerve of abdominal segment
def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment nerve" EXACT []
is_a: UBERON:0003439 ! nerve of trunk region
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003826
name: upper leg bone
def: "A bone that is part of a hindlimb stylopod [Automatically generated definition]." []
synonym: "femur" RELATED []
is_a: UBERON:0005893 ! leg bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0003827
name: thoracic segment bone
def: "A bone that is part of a thorax [Automatically generated definition]." []
synonym: "bone of thorax" EXACT []
synonym: "bone organ of thorax" EXACT []
synonym: "thorax bone" EXACT []
synonym: "thorax bone organ" EXACT []
synonym: "upper body bone" RELATED []
is_a: UBERON:0003463 ! trunk bone
is_a: UBERON:0005181 ! thoracic segment organ
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0003828
name: abdominal segment bone
def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment of trunk bone" EXACT []
synonym: "abdominal segment of trunk bone organ" EXACT []
synonym: "bone of abdominal segment of trunk" EXACT []
synonym: "bone organ of abdominal segment of trunk" EXACT []
is_a: UBERON:0003463 ! trunk bone
is_a: UBERON:0005173 ! abdominal segment element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003829
name: urethra muscle tissue
def: "Any muscle tissue that is part of the urethra." []
synonym: "urethral muscle layer" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005090 ! muscle structure
intersection_of: UBERON:0005090 ! muscle structure
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0003830
name: thoracic segment muscle
def: "Any muscle organ that is part of a thorax [Automatically generated definition]." []
synonym: "muscle organ of thorax" EXACT []
synonym: "thorax muscle organ" EXACT []
synonym: "upper body muscle" RELATED []
is_a: UBERON:0001774 ! skeletal muscle of trunk
is_a: UBERON:0005181 ! thoracic segment organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0004464 ! musculature of thorax

[Term]
id: UBERON:0003831
name: respiratory system muscle
def: "Any muscle organ that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius muscle organ" EXACT []
synonym: "muscle organ of apparatus respiratorius" EXACT []
synonym: "muscle organ of respiratory system" EXACT []
synonym: "respiratory system muscle organ" EXACT []
is_a: UBERON:0001630 ! muscle organ
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0003832
name: esophagus muscle
def: "Any muscle organ that is part of a esophagus [Automatically generated definition]." []
synonym: "esophageal muscle" EXACT []
synonym: "esophagus muscle organ" EXACT []
synonym: "gullet muscle organ" EXACT []
synonym: "muscle organ of esophagus" EXACT []
synonym: "muscle organ of gullet" EXACT []
synonym: "muscle organ of oesophagus" EXACT []
synonym: "oesophagus muscle organ" EXACT []
is_a: UBERON:0001630 ! muscle organ
is_a: UBERON:0005181 ! thoracic segment organ
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001096 ! wall of esophagus

[Term]
id: UBERON:0003833
name: abdominal segment muscle
def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment of trunk muscle organ" EXACT []
synonym: "muscle organ of abdominal segment of trunk" EXACT []
is_a: UBERON:0001774 ! skeletal muscle of trunk
is_a: UBERON:0005173 ! abdominal segment element
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003834
name: thoracic segment blood vessel
def: "A blood vessel that is part of a thorax [Automatically generated definition]." []
synonym: "blood vessel of thorax" EXACT []
synonym: "thorax blood vessel" EXACT []
synonym: "upper body blood vessel" RELATED []
is_a: UBERON:0003513 ! trunk blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0003835
name: abdominal segment blood vessel
def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment of trunk blood vessel" EXACT []
synonym: "blood vessel of abdominal segment of trunk" EXACT []
is_a: UBERON:0003513 ! trunk blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003836
name: abdominal segment skin
def: "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment of trunk skin" EXACT []
synonym: "skin of abdominal segment of trunk" EXACT []
is_a: UBERON:0001085 ! skin of trunk
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003837
name: thoracic segment connective tissue
def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." []
synonym: "connective tissue of thorax" EXACT []
synonym: "portion of connective tissue of thorax" EXACT []
synonym: "textus connectivus of thorax" EXACT []
synonym: "thorax connective tissue" EXACT []
synonym: "thorax portion of connective tissue" EXACT []
synonym: "thorax textus connectivus" EXACT []
synonym: "upper body connective tissue" RELATED []
is_a: UBERON:0003586 ! trunk connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0003838
name: abdominal segment connective tissue
def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." []
synonym: "abdominal segment of trunk connective tissue" EXACT []
synonym: "abdominal segment of trunk portion of connective tissue" EXACT []
synonym: "abdominal segment of trunk textus connectivus" EXACT []
synonym: "connective tissue of abdominal segment of trunk" EXACT []
synonym: "portion of connective tissue of abdominal segment of trunk" EXACT []
synonym: "textus connectivus of abdominal segment of trunk" EXACT []
is_a: UBERON:0003586 ! trunk connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0003839
name: forelimb joint
def: "A limb joint that is part of a forelimb [Automatically generated definition]." []
synonym: "anteriormost limb joint of limb" EXACT []
synonym: "anteriormost limb limb joint" EXACT []
synonym: "fore limb joint of limb" EXACT []
synonym: "fore limb limb joint" EXACT []
synonym: "forelimb joint of limb" EXACT []
synonym: "forelimb limb joint" EXACT []
synonym: "joint of free upper limb" EXACT []
synonym: "joint of limb of anteriormost limb" EXACT []
synonym: "joint of limb of fore limb" EXACT []
synonym: "joint of limb of forelimb" EXACT []
synonym: "joint of limb of superior member" EXACT []
synonym: "joint of limb of upper extremity" EXACT []
synonym: "limb joint of anteriormost limb" EXACT []
synonym: "limb joint of fore limb" EXACT []
synonym: "limb joint of forelimb" EXACT []
synonym: "limb joint of superior member" EXACT []
synonym: "limb joint of upper extremity" EXACT []
synonym: "superior member joint of limb" EXACT []
synonym: "superior member limb joint" EXACT []
synonym: "upper extremity joint of limb" EXACT []
synonym: "upper extremity limb joint" EXACT []
synonym: "wing joint" NARROW []
is_a: UBERON:0003657 ! limb joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003840
name: hindlimb joint
def: "A limb joint that is part of a hindlimb [Automatically generated definition]." []
synonym: "hind limb joint of limb" EXACT []
synonym: "hind limb limb joint" EXACT []
synonym: "hindlimb joint of limb" EXACT []
synonym: "hindlimb limb joint" EXACT []
synonym: "inferior member joint of limb" EXACT []
synonym: "inferior member limb joint" EXACT []
synonym: "joint of free lower limb" EXACT []
synonym: "joint of limb of hind limb" EXACT []
synonym: "joint of limb of hindlimb" EXACT []
synonym: "joint of limb of inferior member" EXACT []
synonym: "joint of limb of lower extremity" EXACT []
synonym: "joint of lower limb" EXACT []
synonym: "limb joint of hind limb" EXACT []
synonym: "limb joint of hindlimb" EXACT []
synonym: "limb joint of inferior member" EXACT []
synonym: "limb joint of lower extremity" EXACT []
synonym: "lower extremity joint of limb" EXACT []
synonym: "lower extremity limb joint" EXACT []
is_a: UBERON:0003657 ! limb joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003841
name: autopod joint
def: "A limb joint that is part of an autopod [Automatically generated definition]." []
synonym: "autopod joint of limb" EXACT []
synonym: "autopod limb joint" EXACT []
synonym: "distal free limb segment joint of limb" EXACT []
synonym: "distal free limb segment limb joint" EXACT []
synonym: "joint of limb of autopod" EXACT []
synonym: "joint of limb of distal free limb segment" EXACT []
synonym: "limb joint of autopod" EXACT []
synonym: "limb joint of distal free limb segment" EXACT []
synonym: "paw joint" RELATED []
is_a: UBERON:0003657 ! limb joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0002470 ! autopod region

[Term]
id: UBERON:0003843
name: dental epithelium
def: "Epithelium that is part of a developing tooth or dental organ." []
synonym: "dental epithelia" EXACT []
synonym: "dental epithelium" EXACT []
synonym: "odontogenic epithelium" EXACT []
synonym: "reduced enamel epithelium" RELATED []
synonym: "tooth epithelium" EXACT []
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0005176 ! tooth enamel organ
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: UBERON:0003846
name: thymus epithelium
def: "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." []
synonym: "epithelial tissue of thymus" EXACT []
synonym: "epithelial tissue of thymus gland" EXACT []
synonym: "epithelium of thymus" EXACT []
synonym: "epithelium of thymus gland" EXACT []
synonym: "thymic epithelial tissue" EXACT []
synonym: "thymic epithelium" EXACT []
synonym: "thymus epithelial tissue" EXACT []
synonym: "thymus gland epithelial tissue" EXACT []
synonym: "thymus gland epithelium" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0003849
name: mesencephalic neural crest
def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." []
synonym: "mesencephalic neural crest" EXACT []
synonym: "neural crest midbrain" EXACT []
is_a: UBERON:0002342 ! neural crest
is_a: UBERON:0003099 ! cranial neural crest

[Term]
id: UBERON:0003852
name: rhombencephalon neural crest
def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." []
synonym: "neural crest hindbrain" EXACT []
synonym: "rhombencephalic neural crest" EXACT []
synonym: "rhombomere neural crest" RELATED []
is_a: UBERON:0002342 ! neural crest
is_a: UBERON:0003099 ! cranial neural crest

[Term]
id: UBERON:0003855
name: gonad mesenchyme
def: "Mesenchyme that is part of a developing gonad [Automatically generated definition]." []
synonym: "gonada mesenchyme" EXACT []
synonym: "mesenchyme of gonad" EXACT []
synonym: "mesenchyme of gonada" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000991 ! gonad
relationship: part_of UBERON:0000991 ! gonad

[Term]
id: UBERON:0003856
name: odontogenic mesenchyme
def: "Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla." []
synonym: "dental mesenchyme" EXACT []
synonym: "dental organ mesenchyme" EXACT []
synonym: "enamel organ mesenchyme" EXACT []
synonym: "tooth enamel organ mesenchyme" EXACT []
synonym: "tooth mesenchyme" EXACT []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0005176 ! tooth enamel organ
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0005176 ! tooth enamel organ

[Term]
id: UBERON:0003859
name: forelimb mesenchyme
def: "Mesenchyme that is part of a developing forelimb [Automatically generated definition]." []
synonym: "anteriormost limb mesenchyme" EXACT []
synonym: "fore limb mesenchyme" EXACT []
synonym: "mesenchyme of anteriormost limb" EXACT []
synonym: "mesenchyme of fore limb" EXACT []
synonym: "mesenchyme of forelimb" EXACT []
synonym: "mesenchyme of superior member" EXACT []
synonym: "mesenchyme of upper extremity" EXACT []
synonym: "superior member mesenchyme" EXACT []
synonym: "upper extremity mesenchyme" EXACT []
synonym: "wing mesenchyme" NARROW []
is_a: UBERON:0009749 ! limb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0003860
name: hindlimb mesenchyme
def: "Mesenchyme that is part of a developing hindlimb [Automatically generated definition]." []
synonym: "hind limb mesenchyme" EXACT []
synonym: "inferior member mesenchyme" EXACT []
synonym: "lower extremity mesenchyme" EXACT []
synonym: "mesenchyme of hind limb" EXACT []
synonym: "mesenchyme of hindlimb" EXACT []
synonym: "mesenchyme of inferior member" EXACT []
synonym: "mesenchyme of lower extremity" EXACT []
is_a: UBERON:0009749 ! limb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0003885
name: mesometrium
def: "A mesentery that is part of a uterus [Automatically generated definition]." []
synonym: "mesentery of uterus" RELATED []
is_a: UBERON:0001297 ! serosa of uterus
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000459 ! uterine wall
relationship: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0012332 ! broad ligament of uterus

[Term]
id: UBERON:0003887
name: intraembryonic coelom
def: "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom" []
synonym: "somatic coelom" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: part_of UBERON:0011997 ! coelom

[Term]
id: UBERON:0003889
name: fallopian tube
def: "Initial section of the oviduct through which the ova pass from the ovary to the uterus" []
synonym: "fallopian tubes" RELATED []
synonym: "female paramesonephric duct" RELATED []
synonym: "mammalian oviduct" EXACT []
synonym: "paramesonephric duct of female" RELATED []
synonym: "salpinges" BROAD []
synonym: "salpinx" BROAD []
synonym: "tuba uterina" RELATED []
synonym: "uterine tube (sensu Mammalia)" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013515 ! subdivision of oviduct
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0013515 ! subdivision of oviduct
intersection_of: develops_from UBERON:0003890 ! Mullerian duct
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: develops_from UBERON:0003890 ! Mullerian duct
relationship: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0003890
name: Mullerian duct
def: "paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM]." []
synonym: "ductus paramesonephricus" EXACT []
synonym: "early paramesonephric duct" NARROW []
synonym: "Muellerian duct" EXACT []
synonym: "Müllerian duct" EXACT []
synonym: "paramesonephric duct" EXACT []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0003891
name: stroma
def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." []
synonym: "stromal connective tissue" RELATED []
is_a: UBERON:0000064 ! organ part

[Term]
id: UBERON:0003893
name: capsule
def: "A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP]." []
is_a: UBERON:0000158 ! membranous layer

[Term]
id: UBERON:0003894
name: liver primordium
def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." []
synonym: "embryological hepatic plate" EXACT []
synonym: "hepatic plate" RELATED []
synonym: "liver bud" RELATED []
synonym: "liver endoderm" RELATED []
synonym: "primordium of the liver" EXACT []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
relationship: develops_from UBERON:0001041 ! foregut
relationship: part_of UBERON:0009550 ! endoderm of foregut-midgut junction

[Term]
id: UBERON:0003897
name: axial muscle
def: "One of the skeletal muscles of the head and neck, spine, and ribs." []
is_a: UBERON:0014892 ! skeletal muscle organ
relationship: part_of UBERON:0013700 ! axial musculature
relationship: part_of UBERON:0013701 ! main body axis

[Term]
id: UBERON:0003898
name: skeletal muscle tissue of trunk
def: "A portion of skeletal muscle tissue in the trunk." []
synonym: "skeletal muscle of torso" EXACT []
synonym: "skeletal muscle tissue of torso" EXACT []
synonym: "skeletal muscle tissue of trunk" EXACT []
synonym: "torso skeletal muscle" EXACT []
synonym: "torso skeletal muscle tissue" EXACT []
synonym: "trunk skeletal muscle" EXACT []
synonym: "trunk skeletal muscle tissue" EXACT []
is_a: UBERON:0001134 ! skeletal muscle tissue
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0004479 ! musculature of trunk
relationship: part_of UBERON:0013700 ! axial musculature

[Term]
id: UBERON:0003902
name: retinal neural layer
def: "The part of the retina that contains neurons and photoreceptor cells[GO]." []
synonym: "neural layer of retina" EXACT []
synonym: "neural retina" EXACT []
synonym: "neural retinal epithelium" RELATED []
synonym: "neuroretina" EXACT []
synonym: "stratum nervosum (retina)" EXACT []
synonym: "stratum nervosum retinae" EXACT []
is_a: UBERON:0001781 ! layer of retina

[Term]
id: UBERON:0003909
name: sinusoid
def: "small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." []
synonym: "endothelium of irregular blood filled space" RELATED []
synonym: "sinusoidal blood vessel" EXACT []
synonym: "sinusoidal blood vessel endothelium" EXACT []
synonym: "sinusoidal capillary" RELATED []
synonym: "sinusoidal endothelium" RELATED []
is_a: UBERON:2005260 ! fenestrated capillary

[Term]
id: UBERON:0003910
name: splenic sinusoid
def: "wide vessels in the spleen that drain into trabecular veins[WP]." []
synonym: "sinusoid of red pulp of spleen" RELATED []
synonym: "sinusoidal blood vessel of spleen" EXACT []
is_a: UBERON:0003497 ! abdomen blood vessel
is_a: UBERON:0003909 ! sinusoid
intersection_of: UBERON:0003909 ! sinusoid
intersection_of: part_of UBERON:0001250 ! red pulp of spleen
relationship: part_of UBERON:0001250 ! red pulp of spleen

[Term]
id: UBERON:0003911
name: choroid plexus epithelium
def: "The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue." []
synonym: "choroid plexus epithelial tissue" EXACT []
synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT []
synonym: "epithelial tissue of choroid plexus" EXACT []
synonym: "epithelium of choroid plexus" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus

[Term]
id: UBERON:0003913
name: tooth-like structure
def: "hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." []
synonym: "tooth-like organ" EXACT []
is_a: UBERON:0004765 ! skeletal element

[Term]
id: UBERON:0003914
name: epithelial tube
def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." []
synonym: "epithelial or endothelial tube" EXACT []
is_a: UBERON:0000025 ! tube
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0003915
name: endothelial tube
def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." []
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0003914 ! epithelial tube

[Term]
id: UBERON:0003918
name: kidney mesenchyme
def: "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." []
synonym: "mesenchyme of kidney" EXACT []
is_a: UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0003920
name: venous blood vessel
def: "A blood vessel that carries blood from the capillaries toward the heart" []
synonym: "segment of venous tree organ" EXACT []
synonym: "venous tree organ segment" EXACT []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0004582 ! venous system
relationship: part_of UBERON:0004582 ! venous system

[Term]
id: UBERON:0003921
name: pancreas primordium
def: "embryonic structure that develops into pancreatic bud." []
synonym: "pancreatic anlage" RELATED []
synonym: "pancreatic endoderm" RELATED []
synonym: "pancreatic primordium" EXACT []
synonym: "primordial pancreas" RELATED []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0007026 ! presumptive gut

[Term]
id: UBERON:0003922
name: pancreatic epithelial bud
def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." []
synonym: "pancreas epithelium" RELATED []
synonym: "pancreatic anlage" RELATED []
synonym: "pancreatic bud" EXACT []
synonym: "pancreatic buds" EXACT []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0007499 ! epithelial sac
relationship: develops_from UBERON:0001041 ! foregut
relationship: develops_from UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0002114 ! duodenum
relationship: develops_from UBERON:0009497 ! epithelium of foregut-midgut junction
relationship: part_of UBERON:0003921 ! pancreas primordium

[Term]
id: UBERON:0003923
name: dorsal pancreatic bud
def: "pancreatic bud that gives rise to the accessory pancreatic duct." []
synonym: "dorsal pancreas anlage" RELATED []
synonym: "dorsal pancreatic anlage" RELATED []
synonym: "pancreas dorsal primordium duct bud" EXACT []
synonym: "pancreas primordium dorsal bud" EXACT []
synonym: "posterior pancreatic anlage" RELATED []
synonym: "posterior pancreatic bud" RELATED []
synonym: "primary pancreatic bud" EXACT []
is_a: UBERON:0003922 ! pancreatic epithelial bud
relationship: develops_from UBERON:0001045 ! midgut
relationship: part_of UBERON:0010375 ! pancreas dorsal primordium

[Term]
id: UBERON:0003924
name: ventral pancreatic bud
def: "pancreatic bud that gives rise to the major pancreatic duct." []
synonym: "anterior pancreatic anlage" RELATED []
synonym: "anterior pancreatic bud" RELATED []
synonym: "pancreas primordium ventral bud" EXACT []
synonym: "pancreas ventral primordium duct bud" EXACT []
synonym: "ventral pancreas anlage" RELATED []
synonym: "ventral pancreatic anlage" RELATED []
is_a: UBERON:0003922 ! pancreatic epithelial bud
relationship: develops_from UBERON:0008835 ! hepatic diverticulum
relationship: part_of UBERON:0010376 ! pancreas ventral primordium

[Term]
id: UBERON:0003928
name: digestive system duct
def: "A duct that is part of a digestive system [Automatically generated definition]." []
synonym: "duct of digestive system" EXACT []
synonym: "duct of gastrointestinal system" EXACT []
synonym: "gastrointestinal system duct" EXACT []
is_a: UBERON:0000058 ! duct
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0003929
name: digestive tract epithelium
def: "An epithelium that lines the lumen of the digestive tract." []
synonym: "alimentary tract epithelium" RELATED []
synonym: "digestive tract epithelial tissue" EXACT []
synonym: "epithelial tissue of digestive tract" EXACT []
synonym: "epithelial tissue of gut" EXACT []
synonym: "epithelium of digestive tract" EXACT []
synonym: "epithelium of gut" EXACT []
synonym: "gastrodermis" EXACT []
synonym: "gut epithelial tissue" EXACT []
synonym: "gut epithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0003931
name: diencephalic white matter
def: "White matter that is part of a diencephalon [Automatically generated definition]." []
synonym: "diencephalic tract/commissure" EXACT []
synonym: "diencephalic tracts and commissures" EXACT []
synonym: "predominantly white regional part of diencephalon" EXACT []
synonym: "white matter of diencephalon" EXACT []
is_a: UBERON:0019261 ! white matter of forebrain
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0003932
name: cartilage element of chondrocranium
def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." []
synonym: "cartilage of chondrocranium" EXACT []
synonym: "cartilaginous element of chondrocranium" EXACT []
synonym: "chondrocranium cartilage" EXACT []
synonym: "neurocranium cartilage" EXACT []
is_a: UBERON:0003933 ! cranial cartilage
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0002241 ! chondrocranium
relationship: part_of UBERON:0002241 ! chondrocranium

[Term]
id: UBERON:0003933
name: cranial cartilage
def: "A cartilage element that is part of the cranial skeleton." []
synonym: "cartilage of cranium" EXACT []
synonym: "cranial cartilages" RELATED []
synonym: "cranium cartilage" EXACT []
is_a: UBERON:0007844 ! cartilage element
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0010323 ! cranial skeletal system
relationship: part_of UBERON:0010323 ! cranial skeletal system

[Term]
id: UBERON:0003937
name: sex gland
def: "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." []
synonym: "genitalia gland" EXACT []
synonym: "gland of genitalia" EXACT []
synonym: "gland of reproductive system" EXACT []
synonym: "reproductive gland" EXACT []
synonym: "reproductive system gland" EXACT []
is_a: UBERON:0002530 ! gland
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000990 ! reproductive system
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0003942
name: somatic sensory system
def: "The sensory system for the sense of touch and pain." []
synonym: "somatic sensory system" EXACT []
synonym: "somatosensory system" EXACT []
synonym: "system for detection of somatic senses" EXACT []
is_a: UBERON:0001032 ! sensory system
intersection_of: UBERON:0001032 ! sensory system
intersection_of: part_of UBERON:0000012 ! somatic nervous system
relationship: part_of UBERON:0000012 ! somatic nervous system

[Term]
id: UBERON:0003947
name: brain ventricle/choroid plexus
def: "The brain ventricles or their associated choroid plexuses" []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010000 ! multicellular anatomical structure
union_of: UBERON:0001886 ! choroid plexus
union_of: UBERON:0004086 ! brain ventricle
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0003956
name: aqueous drainage system
def: "The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins" []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001768 ! uvea

[Term]
id: UBERON:0003967
name: cutaneous elastic tissue
def: "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" []
synonym: "cutaneous elastic fiber" NARROW []
synonym: "dermal elastic fiber" NARROW []
is_a: UBERON:0002521 ! elastic tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0002521 ! elastic tissue
intersection_of: part_of UBERON:0000014 ! zone of skin
relationship: part_of UBERON:0000014 ! zone of skin

[Term]
id: UBERON:0003970
name: placental labyrinth vasculature
def: "blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" []
synonym: "placenta vascular network" EXACT []
synonym: "placenta vasculature" EXACT []
synonym: "vascular network of placenta" EXACT []
synonym: "vasculature of placenta" EXACT []
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta

[Term]
id: UBERON:0003975
name: internal female genitalia
def: "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." []
synonym: "female internal genitalia" EXACT []
synonym: "internal female genital organ" EXACT []
synonym: "internal genitalia of female reproductive system" EXACT []
synonym: "organa genitalia feminina interna" RELATED []
is_a: UBERON:0003134 ! female reproductive organ
is_a: UBERON:0004175 ! internal genitalia
intersection_of: UBERON:0004175 ! internal genitalia
intersection_of: part_of UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0000474 ! female reproductive system

[Term]
id: UBERON:0003988
name: thymus corticomedullary boundary
def: "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" []
synonym: "thymic cortico-medullary boundary" EXACT []
synonym: "thymic corticomedullary boundary" EXACT []
synonym: "thymic corticomedullary junction" EXACT []
synonym: "thymic corticomedullary zone" EXACT []
synonym: "thymus CMZ" EXACT []
synonym: "thymus cortico-medullary boundary" EXACT []
synonym: "thymus corticomedullary junction" EXACT []
synonym: "thymus corticomedullary zone" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0007651 ! anatomical junction
relationship: has_part UBERON:0001980 ! arteriole
relationship: part_of UBERON:0002125 ! thymus lobule

[Term]
id: UBERON:0003990
name: spinal cord motor column
def: "The subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target" []
is_a: UBERON:0016550 ! spinal cord column

[Term]
id: UBERON:0004001
name: olfactory bulb layer
def: "." []
synonym: "cytoarchitectural part of olfactory bulb" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0022303 ! nervous system cell part layer
intersection_of: UBERON:0022303 ! nervous system cell part layer
intersection_of: part_of UBERON:0002264 ! olfactory bulb
relationship: part_of UBERON:0002264 ! olfactory bulb

[Term]
id: UBERON:0004016
name: dermatome
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." []
synonym: "cutis plate" EXACT []
synonym: "dermatomal mesenchyme" EXACT []
synonym: "epimere mesoderm" RELATED []
synonym: "mesenchyma dermatomiale" RELATED []
is_a: UBERON:0017650 ! developing mesenchymal structure
relationship: develops_from UBERON:0002329 ! somite
relationship: develops_from UBERON:0004290 ! dermomyotome

[Term]
id: UBERON:0004022
name: germinal neuroepithelium
def: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells" []
synonym: "germinal neuroepithelial layer" EXACT []
synonym: "germinal neuroepithelium" EXACT []
synonym: "original neural tube" EXACT []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034706 ! proliferating neuroepithelium
disjoint_from: UBERON:0006934 ! sensory epithelium
relationship: part_of UBERON:0001049 ! neural tube

[Term]
id: UBERON:0004041
name: spleen primary B follicle
def: "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" []
synonym: "primary spleen B cell follicle" EXACT []
is_a: UBERON:0001249 ! spleen lymphoid follicle
is_a: UBERON:0010422 ! primary nodular lymphoid tissue
intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0004042
name: spleen secondary B follicle
def: "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" []
synonym: "secondary spleen B cell follicle" EXACT []
synonym: "splenic secondary B cell follicle" EXACT []
is_a: UBERON:0001249 ! spleen lymphoid follicle
is_a: UBERON:0001745 ! secondary nodular lymphoid tissue
intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue
intersection_of: part_of UBERON:0002106 ! spleen
relationship: develops_from UBERON:0004041 ! spleen primary B follicle
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0004043
name: semicircular canal ampulla
def: "The spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" []
synonym: "ampullae osseae" RELATED []
synonym: "membraneous ampulla of the semicircular duct" RELATED []
synonym: "semicircular duct ampulla" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010000 ! multicellular anatomical structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001840 ! semicircular canal
relationship: part_of UBERON:0001856 ! semicircular duct

[Term]
id: UBERON:0004044
name: anterior visceral endoderm
def: "The extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" []
synonym: "AVE" RELATED []
is_a: UBERON:0004877 ! visceral endoderm

[Term]
id: UBERON:0004053
name: external male genitalia
def: "The external masculine genital organs, including the penis and scrotum" []
synonym: "external male genital organ" EXACT []
synonym: "male external genitalia" EXACT []
synonym: "organa genitalia masculina externa" RELATED []
is_a: UBERON:0003135 ! male reproductive organ
is_a: UBERON:0004176 ! external genitalia
intersection_of: UBERON:0004176 ! external genitalia
intersection_of: part_of UBERON:0000079 ! male reproductive system
disjoint_from: UBERON:0005056 ! external female genitalia
disjoint_from: UBERON:0009196 ! indifferent external genitalia
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0004054
name: internal male genitalia
def: "The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" []
synonym: "internal male genital organ" EXACT []
synonym: "male internal genitalia" EXACT []
synonym: "organa genitalia masculina interna" RELATED []
is_a: UBERON:0003135 ! male reproductive organ
is_a: UBERON:0004175 ! internal genitalia
intersection_of: UBERON:0004175 ! internal genitalia
intersection_of: part_of UBERON:0000079 ! male reproductive system
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0004059
name: spinal cord medial motor column
def: "The subclasses of motor neurons which project their axons to axial muscles that lie close to the vertebral column; motor neurons in the lateral subdivision of the MMC project their axons to body wall muscles" []
is_a: UBERON:0003990 ! spinal cord motor column

[Term]
id: UBERON:0004061
name: neural tube mantle layer
def: "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." []
synonym: "future brain marginal layer" RELATED []
synonym: "neural tube intermediate zone" EXACT []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034707 ! differentiating neuroepithelium
relationship: develops_from UBERON:0004022 ! germinal neuroepithelium
relationship: part_of UBERON:0001049 ! neural tube

[Term]
id: UBERON:0004066
name: frontonasal prominence
def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." []
synonym: "embryonic frontonasal prominence" EXACT []
synonym: "forebrain prominence" RELATED []
synonym: "frontonasal mass" RELATED []
synonym: "frontonasal process" RELATED []
synonym: "prominentia frontonasalis" RELATED []
is_a: UBERON:0009292 ! embryonic nasal process

[Term]
id: UBERON:0004068
name: medial nasal prominence
def: "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" []
synonym: "medial nasal process" EXACT []
synonym: "medial nasal swelling" RELATED []
synonym: "medial-nasal process" EXACT []
synonym: "nasomedial prominence" RELATED []
synonym: "prominentia nasalis medialis" EXACT []
is_a: UBERON:0009292 ! embryonic nasal process
relationship: develops_from UBERON:0004066 ! frontonasal prominence
relationship: part_of UBERON:0004066 ! frontonasal prominence

[Term]
id: UBERON:0004086
name: brain ventricle
def: "one of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid" []
synonym: "brain ventricles" EXACT []
synonym: "cerebral ventricle" EXACT []
synonym: "region of ventricular system of brain" EXACT []
is_a: UBERON:0003947 ! brain ventricle/choroid plexus
is_a: UBERON:0005358 ! ventricle of nervous system
relationship: part_of UBERON:0005282 ! ventricular system of brain

[Term]
id: UBERON:0004088
name: orbital region
def: "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present" []
synonym: "content of orbital part of eye" EXACT []
synonym: "eye region" EXACT []
synonym: "ocular and peri-ocular region" RELATED []
synonym: "ocular region" RELATED []
synonym: "orbital content" RELATED []
synonym: "orbital part of eye" RELATED []
synonym: "orbital part of face" EXACT []
is_a: UBERON:0001444 ! subdivision of head
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0004111
name: anatomical conduit
def: "Any tube, opening or passage that connects two distinct anatomical spaces." []
synonym: "foramen" NARROW []
synonym: "foramina" NARROW []
synonym: "opening" RELATED []
synonym: "ostia" RELATED []
synonym: "ostium" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: has_part UBERON:0013686 ! anatomical conduit space

[Term]
id: UBERON:0004117
name: pharyngeal pouch
def: "An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches." []
synonym: "branchial pouch" EXACT []
synonym: "pharyngeal pouches" RELATED []
synonym: "visceral pouch" EXACT []
synonym: "visceral pouches" RELATED []
is_a: UBERON:0003258 ! endoderm of foregut
is_a: UBERON:0004814 ! upper respiratory tract epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0008814 ! pharyngeal arch system

[Term]
id: UBERON:0004118
name: vasculature of iris
def: "A vasculature that is part of a iris [Automatically generated definition]." []
synonym: "iris blood vessels" EXACT []
synonym: "iris vascular network" EXACT []
synonym: "iris vasculature" EXACT []
synonym: "vascular network of iris" EXACT []
is_a: UBERON:0002203 ! vasculature of eye
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0004119
name: endoderm-derived structure
def: "An anatomical structure that develops (entirely or partially) from the endoderm." []
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000925 ! endoderm
relationship: develops_from UBERON:0000925 ! endoderm

[Term]
id: UBERON:0004120
name: mesoderm-derived structure
def: "An anatomical structure that develops (entirely or partially) from the mesoderm." []
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0004121
name: ectoderm-derived structure
def: "An anatomical structure that develops (entirely or partially) from the ectoderm." []
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
relationship: develops_from UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0004122
name: genitourinary system
def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." []
synonym: "genito-urinary system" RELATED []
synonym: "genitourinary tract" RELATED []
synonym: "GU tract" RELATED []
synonym: "UG tract" RELATED []
synonym: "urogenital system" EXACT []
synonym: "urogenital tract" RELATED []
synonym: "Urogenitalsystem" RELATED []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: has_part UBERON:0000990 ! reproductive system
intersection_of: has_part UBERON:0001008 ! renal system
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: has_part UBERON:0000990 ! reproductive system
relationship: has_part UBERON:0001008 ! renal system

[Term]
id: UBERON:0004123
name: myocardial layer
def: "Any of the layers of the myocardium. Example: compact layer, trabecular layer." []
synonym: "layer of myocardium" EXACT []
synonym: "myocardium layer" EXACT []
is_a: UBERON:0005983 ! heart layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: part_of UBERON:0002349 ! myocardium
relationship: part_of UBERON:0002349 ! myocardium

[Term]
id: UBERON:0004128
name: optic vesicle
def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." []
synonym: "evagination" RELATED []
synonym: "eye vesicle" RELATED []
synonym: "ocular vesicle" RELATED []
synonym: "optic vesicles" RELATED []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: develops_from UBERON:0003071 ! eye primordium
relationship: part_of UBERON:0010312 ! immature eye

[Term]
id: UBERON:0004129
name: growth plate cartilage
def: "cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." []
synonym: "growth plate" RELATED []
is_a: UBERON:0002418 ! cartilage tissue
relationship: part_of UBERON:0010363 ! endochondral element

[Term]
id: UBERON:0004130
name: cerebellar layer
def: "A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo." []
synonym: "cell layer of cerebellar cortex" EXACT []
synonym: "gray matter layer of cerebellum" EXACT []
synonym: "layer of cerebellar cortex" EXACT []
synonym: "layer of cerebellum" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0016548 ! central nervous system gray matter layer
intersection_of: UBERON:0016548 ! central nervous system gray matter layer
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: UBERON:0004134
name: proximal tubule
def: "In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]." []
synonym: "kidney proximal tubule" EXACT []
synonym: "proximal kidney tubule" EXACT []
synonym: "renal proximal tubule" EXACT []
is_a: UBERON:0006853 ! renal cortex tubule
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001231 ! nephron tubule

[Term]
id: UBERON:0004135
name: distal tubule
def: "The distal tubule is a nephron tubule that consists of the distal convoluted tubule and distal straight tubule segments" []
synonym: "kidney distal tubule" EXACT []
synonym: "renal distal tubule" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule

[Term]
id: UBERON:0004136
name: intermediate tubule
def: "The intermediate tubule is a nephron tubule that lies between the proximal and distal tubules" []
synonym: "renal intermediate tubule" EXACT []
synonym: "tubulus attenuatus" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule
relationship: part_of UBERON:0001288 ! loop of Henle

[Term]
id: UBERON:0004139
name: cardiogenic plate
def: "The first recognizable structure derived from the heart field" []
synonym: "cardiac crescent" RELATED []
synonym: "cardiogenic crescent" RELATED []
synonym: "heart rudiment" RELATED []
synonym: "myocardial plate" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003084 ! heart primordium
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0004140
name: primary heart field
def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." []
synonym: "FHF" RELATED []
synonym: "first heart field" EXACT []
synonym: "heart field" RELATED []
synonym: "PHF" RELATED []
synonym: "primary heart field" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007688 ! anlage
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0004141
name: heart tube
def: "An epithelial tube that will give rise to the mature heart." []
synonym: "embryonic heart tube" EXACT []
synonym: "endocardial heart tube" EXACT []
synonym: "endocardial tube" EXACT []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0012275 ! meso-epithelium
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0004142
name: outflow tract septum
def: "The outflow tract septum is a partition in the outflow tract" []
is_a: UBERON:0002099 ! cardiac septum
intersection_of: UBERON:0002099 ! cardiac septum
intersection_of: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0004145
name: outflow tract
def: "The outflow tract is the portion of the heart through which blood flows into the arteries" []
synonym: "arterial (outflow) pole" RELATED []
synonym: "cardiac outflow tract" EXACT []
synonym: "heart outflow tract" EXACT []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0004146
name: His-Purkinje system
def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles" []
synonym: "distal conduction system" EXACT []
synonym: "His-Purkinji network" EXACT []
synonym: "HPS" EXACT []
is_a: UBERON:0010131 ! conducting tissue of heart
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0004151
name: cardiac chamber
def: "A cardiac chamber surrounds an enclosed cavity within the heart" []
synonym: "chamber of heart" EXACT []
synonym: "heart chamber" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0004160
name: proepicardium
def: "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium" []
synonym: "proepicardial cluster" EXACT []
synonym: "proepicardial organ" EXACT []
is_a: UBERON:0003104 ! mesenchyme
relationship: part_of UBERON:0004161 ! septum transversum
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0004161
name: septum transversum
def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." []
synonym: "transverse septum" EXACT []
is_a: UBERON:0003104 ! mesenchyme
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0004164
name: branchiomeric muscle
def: "A jaw muscle that arises from cranial mesenchyme and is innervated by cranial nerves." []
synonym: "branchial head muscle" EXACT []
synonym: "branchiomeric skeletal muscle" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001630 ! muscle organ
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme

[Term]
id: UBERON:0004175
name: internal genitalia
def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals" []
synonym: "internal genitalia" EXACT []
synonym: "internal genitals" EXACT []
synonym: "internal reproductive organ" RELATED []
synonym: "internal sex organ" RELATED []
is_a: UBERON:0003133 ! reproductive organ

[Term]
id: UBERON:0004176
name: external genitalia
def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals" []
synonym: "external genitalia" EXACT []
synonym: "external reproductive organ" RELATED []
synonym: "external sex organ" RELATED []
is_a: UBERON:0003133 ! reproductive organ

[Term]
id: UBERON:0004177
name: hemopoietic organ
def: "Organ that is part of the hematopoietic system." []
synonym: "haematological system organ" EXACT []
synonym: "haemopoietic system organ" EXACT []
synonym: "hematopoeitic or lymphoid organ" NARROW []
synonym: "hematopoeitic organ" EXACT []
synonym: "hematopoietic system organ" EXACT []
synonym: "lymph organ" NARROW []
synonym: "lymphoid organ" NARROW []
synonym: "organ of haematological system" EXACT []
synonym: "organ of haemopoietic system" EXACT []
synonym: "organ of hematopoietic system" EXACT []
synonym: "organ of organa haemopoietica" EXACT []
synonym: "organa haemopoietica organ" EXACT []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0002390 ! hematopoietic system
relationship: part_of UBERON:0002390 ! hematopoietic system

[Term]
id: UBERON:0004178
name: aorta smooth muscle tissue
def: "the nonstriated, involuntary muscle tissue located in the wall of the aorta" []
synonym: "aorta non-striated muscle" EXACT []
synonym: "aorta smooth muscle" EXACT []
synonym: "aortic smooth muscle" EXACT []
is_a: UBERON:0004237 ! blood vessel smooth muscle
is_a: UBERON:0004695 ! arterial system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0004179
name: prostate glandular acinus
def: "A saclike structure of the prostate gland, comprised of at least three cell layers: an innermost layer of secretory columnar luminal epithelium, a middle layer of squamous basal epithelium that also contains neuroendocrine cells, transit amplifying cells, and stem cells, and an outer layer of smooth muscle intermixed with other stromal cells" []
synonym: "prostatic acinus" EXACT []
synonym: "prostatic follicle" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0009842 ! glandular acinus
relationship: develops_from UBERON:0009843 ! prostate epithelial cord
relationship: part_of UBERON:0000428 ! prostate epithelium
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0004180
name: mammary gland fat
def: "The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts" []
synonym: "adipose tissue of lactiferous gland" EXACT []
synonym: "adipose tissue of mammary gland" EXACT []
synonym: "fat tissue of lactiferous gland" EXACT []
synonym: "fat tissue of lobe of breast" EXACT []
synonym: "fat tissue of lobe of mammary gland" EXACT []
synonym: "fat tissue of mammary gland" EXACT []
synonym: "fatty tissue of lactiferous gland" EXACT []
synonym: "fatty tissue of lobe of breast" EXACT []
synonym: "fatty tissue of lobe of mammary gland" EXACT []
synonym: "fatty tissue of mammary gland" EXACT []
synonym: "lactiferous gland adipose tissue" EXACT []
synonym: "lactiferous gland fat tissue" EXACT []
synonym: "lactiferous gland fatty tissue" EXACT []
synonym: "lobe of breast adipose tissue" EXACT []
synonym: "lobe of breast fat tissue" EXACT []
synonym: "lobe of breast fatty tissue" EXACT []
synonym: "lobe of mammary gland adipose tissue" EXACT []
synonym: "lobe of mammary gland fat tissue" EXACT []
synonym: "lobe of mammary gland fatty tissue" EXACT []
synonym: "mammary gland adipose tissue" EXACT []
synonym: "mammary gland fat tissue" EXACT []
synonym: "mammary gland fatty tissue" EXACT []
is_a: UBERON:0001013 ! adipose tissue
is_a: UBERON:0003584 ! mammary gland connective tissue
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0004182
name: mammary gland cord
def: "The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis." []
synonym: "lactiferous gland cord" EXACT []
synonym: "mammary cord" EXACT []
synonym: "mammary sprout" RELATED []
is_a: UBERON:0003244 ! epithelium of mammary gland
is_a: UBERON:0005154 ! epithelial cord
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0005154 ! epithelial cord
intersection_of: part_of UBERON:0001765 ! mammary duct
relationship: develops_from UBERON:0005333 ! mammary bud
relationship: part_of UBERON:0001765 ! mammary duct

[Term]
id: UBERON:0004184
name: prostate gland stroma
def: "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland" []
synonym: "prostate stroma" EXACT []
synonym: "prostatic stroma" EXACT []
synonym: "stroma of glandular part of prostate" NARROW []
synonym: "stroma of prostate" EXACT []
synonym: "stroma of prostate gland" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0004185
name: endodermal part of digestive tract
def: "A portions of the gut that is derived from endoderm." []
synonym: "endodermal gut" EXACT []
synonym: "gut endoderm" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004921 ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0004186
name: olfactory bulb mitral cell layer
def: "The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer" []
synonym: "mitral cell body layer" EXACT []
synonym: "mitral cell layer" EXACT []
synonym: "mitral cell layer of the olfactory bulb" RELATED []
synonym: "OB mitral cell layer" EXACT []
synonym: "olfactory bulb main mitral cell body layer" RELATED []
is_a: UBERON:0004001 ! olfactory bulb layer

[Term]
id: UBERON:0004188
name: glomerular epithelium
def: "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." []
synonym: "epithelium of glomerulus" EXACT []
synonym: "epithelium of kidney glomerulus" EXACT []
synonym: "epithelium of renal glomerulus" EXACT []
synonym: "glomerular epithelial cell" RELATED []
synonym: "kidney glomerular epithelium" EXACT []
is_a: UBERON:0004211 ! nephron epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus

[Term]
id: UBERON:0004189
name: glomerular endothelium
def: "The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus" []
synonym: "endothelium of renal glomerulus" EXACT []
synonym: "renal glomerulus endothelium" EXACT []
is_a: UBERON:0004188 ! glomerular epithelium
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0004190 ! renal glomerulus vasculature

[Term]
id: UBERON:0004190
name: renal glomerulus vasculature
def: "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus" []
synonym: "glomerulus vasculature" EXACT []
synonym: "renal glomerulus vascular network" EXACT []
synonym: "renal glomerulus vasculature" EXACT []
synonym: "vascular network of renal glomerulus" EXACT []
synonym: "vasculature of renal glomerulus" EXACT []
is_a: UBERON:0006544 ! kidney vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus

[Term]
id: UBERON:0004193
name: loop of Henle ascending limb thin segment
def: "A sub-portion of the loop of Henle in the nephron of the kidney that is permeable to ions but not to water" []
synonym: "ascending limb thin segment of loop of Henle" EXACT []
synonym: "ascending thin limb" EXACT []
synonym: "pars ascendens (tubulus attenuatus)" EXACT []
synonym: "thin ascending limb" EXACT []
synonym: "thin ascending limb of loop of Henle" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule
is_a: UBERON:0008408 ! distal tubular epithelium
relationship: part_of UBERON:0003455 ! inner renal medulla loop of henle
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle

[Term]
id: UBERON:0004198
name: comma-shaped body
def: "The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron" []
synonym: "CSB" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004209 ! renal vesicle
relationship: part_of UBERON:0010532 ! primitive nephron

[Term]
id: UBERON:0004199
name: S-shaped body
def: "The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron" []
synonym: "SSB" EXACT []
synonym: "stage II nephron" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004198 ! comma-shaped body
relationship: part_of UBERON:0010532 ! primitive nephron

[Term]
id: UBERON:0004200
name: kidney pyramid
def: "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." []
synonym: "malphigian pyramid" RELATED []
synonym: "malpighian pyramid" EXACT []
synonym: "medullary pyramid" RELATED []
synonym: "pyramid" BROAD []
synonym: "pyramid of Malphigi" RELATED []
synonym: "pyramides renales" RELATED []
synonym: "pyramis renalis" RELATED []
synonym: "renal medullary region" RELATED []
synonym: "renal pyramid" EXACT []
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0000362 ! renal medulla

[Term]
id: UBERON:0004201
name: kidney outer medulla inner stripe
def: "The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thick and thin portions of nephron tubules" []
synonym: "inner stripe" EXACT []
synonym: "inner stripe of medulla of kidney" EXACT []
synonym: "inner stripe of outer medulla" EXACT []
synonym: "inner stripe of renal medulla" EXACT []
synonym: "outer medulla inner stripe" EXACT []
synonym: "stria interna medullae renalis" EXACT []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0004202
name: kidney outer medulla outer stripe
def: "The outer stripe is the region of the kidney that lies distal to the line of termination of the straight renal tubules" []
synonym: "outer medulla outer stripe" EXACT []
synonym: "outer stripe" EXACT []
synonym: "outer stripe of medulla of kidney" EXACT []
synonym: "outer stripe of outer medulla" EXACT []
synonym: "outer stripe of renal medulla" EXACT []
synonym: "stria externa medullae renalis" EXACT []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0004203
name: cortical collecting duct
def: "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex" []
synonym: "kidney cortex collecting duct" EXACT []
synonym: "renal cortex collecting duct" RELATED []
is_a: UBERON:0013522 ! subdivision of tube
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: part_of UBERON:0001225 ! cortex of kidney
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: UBERON:0004204
name: outer medullary collecting duct
def: "The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla" []
synonym: "kidney outer medulla collecting duct" EXACT []
synonym: "outer renal medulla collecting duct" EXACT []
is_a: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0004205
name: inner medullary collecting duct
def: "The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla" []
synonym: "inner renal medulla collecting duct" EXACT []
synonym: "kidney inner medulla collecting duct" EXACT []
synonym: "papillary collecting duct" RELATED []
is_a: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney

[Term]
id: UBERON:0004208
name: nephrogenic mesenchyme
def: "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron" []
synonym: "mesenchyme of nephron" EXACT []
synonym: "nephron mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0004209
name: renal vesicle
def: "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." []
synonym: "stage I nephron" EXACT []
is_a: UBERON:0007503 ! epithelial vesicle
relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme
relationship: part_of UBERON:0010536 ! nephron progenitor

[Term]
id: UBERON:0004211
name: nephron epithelium
def: "The nephron epithelium is a tissue that covers the surface of a nephron" []
synonym: "epithelial tissue of nephron" EXACT []
synonym: "epithelium of nephron" EXACT []
synonym: "nephron epithelial tissue" EXACT []
is_a: UBERON:0004819 ! kidney epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0001285 ! nephron

[Term]
id: UBERON:0004212
name: glomerular capillary
def: "the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" []
synonym: "blood capillary of renal glomerulus" EXACT []
synonym: "capillary of renal glomerulus" EXACT []
synonym: "capillary vessel of renal glomerulus" EXACT []
synonym: "glomerular capillaries" RELATED []
synonym: "glomerular capillary system" RELATED []
synonym: "renal glomerulus blood capillary" EXACT []
synonym: "renal glomerulus capillary" EXACT []
synonym: "renal glomerulus capillary vessel" EXACT []
is_a: UBERON:0003527 ! kidney capillary
intersection_of: UBERON:0001982 ! capillary
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0004190 ! renal glomerulus vasculature

[Term]
id: UBERON:0004214
name: upper leg nerve
def: "A nerve that is part of a hindlimb stylopod [Automatically generated definition]." []
synonym: "hind limb stylopod nerve" EXACT []
synonym: "hindlimb stylopod nerve" EXACT []
synonym: "inferior member stylopod nerve" EXACT []
synonym: "lower extremity stylopod nerve" EXACT []
synonym: "nerve of hind limb stylopod" EXACT []
synonym: "nerve of hindlimb stylopod" EXACT []
synonym: "nerve of inferior member stylopod" EXACT []
synonym: "nerve of lower extremity stylopod" EXACT []
synonym: "nerve of Proximal segment of free lower limb" EXACT []
synonym: "nerve of stylopod of hind limb" EXACT []
synonym: "nerve of stylopod of hindlimb" EXACT []
synonym: "nerve of stylopod of inferior member" EXACT []
synonym: "nerve of stylopod of lower extremity" EXACT []
synonym: "nerve of stylopod of lower limb" EXACT []
synonym: "nerve of thigh" EXACT []
synonym: "nerve of upper leg" EXACT []
synonym: "Proximal segment of free lower limb nerve" EXACT []
synonym: "stylopod of hind limb nerve" EXACT []
synonym: "stylopod of hindlimb nerve" EXACT []
synonym: "stylopod of inferior member nerve" EXACT []
synonym: "stylopod of lower extremity nerve" EXACT []
synonym: "stylopod of lower limb nerve" EXACT []
synonym: "thigh nerve" EXACT []
is_a: UBERON:0003431 ! leg nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0004215
name: back nerve
def: "A nerve that is part of a back [Automatically generated definition]." []
synonym: "nerve of back" EXACT []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0004217
name: upper arm nerve
def: "A nerve that is part of a forelimb stylopod [Automatically generated definition]." []
synonym: "arm stylopod nerve" EXACT []
synonym: "brachial region stylopod nerve" EXACT []
synonym: "nerve of arm stylopod" EXACT []
synonym: "nerve of brachial region stylopod" EXACT []
synonym: "nerve of Proximal segment of free upper limb" EXACT []
synonym: "nerve of proximal segment of free upper limb stylopod" EXACT []
synonym: "nerve of stylopod of arm" EXACT []
synonym: "nerve of stylopod of brachial region" EXACT []
synonym: "nerve of stylopod of proximal segment of free upper limb" EXACT []
synonym: "nerve of upper arm" EXACT []
synonym: "Proximal segment of free upper limb nerve" EXACT []
synonym: "proximal segment of free upper limb stylopod nerve" EXACT []
synonym: "stylopod of arm nerve" EXACT []
synonym: "stylopod of brachial region nerve" EXACT []
synonym: "stylopod of proximal segment of free upper limb nerve" EXACT []
is_a: UBERON:0003433 ! arm nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0004219
name: urethra smooth muscle layer
def: "A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition]." []
synonym: "muscle layer of urethra" EXACT []
synonym: "muscular coat of urethra" EXACT []
synonym: "muscular layer of urethra" EXACT []
synonym: "smooth muscle of urethra" EXACT []
synonym: "smooth muscle tissue of urethra" EXACT []
synonym: "tunica muscularis urethrae" EXACT []
synonym: "urethra smooth muscle tissue" EXACT []
synonym: "urethral smooth muscle" RELATED []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0004220
name: large intestine smooth muscle
def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." []
synonym: "involuntary muscle of large intestine" EXACT []
synonym: "large intestine involuntary muscle" EXACT []
synonym: "large intestine non-striated muscle" EXACT []
synonym: "large intestine smooth muscle tissue" EXACT []
synonym: "non-striated muscle of large intestine" EXACT []
synonym: "smooth muscle of large intestine" EXACT []
synonym: "smooth muscle tissue of large intestine" EXACT []
is_a: UBERON:0004221 ! intestine smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine

[Term]
id: UBERON:0004221
name: intestine smooth muscle
def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." []
synonym: "bowel involuntary muscle" EXACT []
synonym: "bowel non-striated muscle" EXACT []
synonym: "bowel smooth muscle" EXACT []
synonym: "bowel smooth muscle tissue" EXACT []
synonym: "intestinal muscularis" RELATED []
synonym: "intestinal smooth muscle" RELATED []
synonym: "intestine involuntary muscle" EXACT []
synonym: "intestine non-striated muscle" EXACT []
synonym: "intestine smooth muscle tissue" EXACT []
synonym: "involuntary muscle of bowel" EXACT []
synonym: "involuntary muscle of intestine" EXACT []
synonym: "non-striated muscle of bowel" EXACT []
synonym: "non-striated muscle of intestine" EXACT []
synonym: "smooth muscle of bowel" EXACT []
synonym: "smooth muscle of intestine" EXACT []
synonym: "smooth muscle tissue of bowel" EXACT []
synonym: "smooth muscle tissue of intestine" EXACT []
is_a: UBERON:0004226 ! gastrointestinal system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 ! wall of intestine

[Term]
id: UBERON:0004222
name: stomach smooth muscle
def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." []
synonym: "gastric muscle" RELATED []
synonym: "gastric smooth muscle" RELATED []
synonym: "involuntary muscle of stomach" EXACT []
synonym: "involuntary muscle of ventriculus" EXACT []
synonym: "non-striated muscle of stomach" EXACT []
synonym: "non-striated muscle of ventriculus" EXACT []
synonym: "smooth muscle of stomach" EXACT []
synonym: "smooth muscle of ventriculus" EXACT []
synonym: "smooth muscle tissue of stomach" EXACT []
synonym: "smooth muscle tissue of ventriculus" EXACT []
synonym: "stomach involuntary muscle" EXACT []
synonym: "stomach muscle" RELATED []
synonym: "stomach non-striated muscle" EXACT []
synonym: "stomach smooth muscle tissue" EXACT []
synonym: "ventriculus involuntary muscle" EXACT []
synonym: "ventriculus non-striated muscle" EXACT []
synonym: "ventriculus smooth muscle" EXACT []
synonym: "ventriculus smooth muscle tissue" EXACT []
is_a: UBERON:0004226 ! gastrointestinal system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0001167 ! wall of stomach

[Term]
id: UBERON:0004223
name: vagina smooth muscle
def: "A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition]." []
synonym: "involuntary muscle of vagina" EXACT []
synonym: "non-striated muscle of vagina" EXACT []
synonym: "smooth muscle of vagina" EXACT []
synonym: "smooth muscle tissue of vagina" EXACT []
synonym: "vagina involuntary muscle" EXACT []
synonym: "vagina non-striated muscle" EXACT []
synonym: "vagina smooth muscle" RELATED []
synonym: "vagina smooth muscle tissue" EXACT []
synonym: "vaginal smooth muscle" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0004225
name: respiratory system smooth muscle
def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." []
synonym: "airway smooth muscle" RELATED []
synonym: "airway smooth muscle cell" RELATED []
synonym: "apparatus respiratorius involuntary muscle" EXACT []
synonym: "apparatus respiratorius non-striated muscle" EXACT []
synonym: "apparatus respiratorius smooth muscle" EXACT []
synonym: "apparatus respiratorius smooth muscle tissue" EXACT []
synonym: "involuntary muscle of apparatus respiratorius" EXACT []
synonym: "involuntary muscle of respiratory system" EXACT []
synonym: "non-striated muscle of apparatus respiratorius" EXACT []
synonym: "non-striated muscle of respiratory system" EXACT []
synonym: "respiratory smooth muscle" EXACT []
synonym: "respiratory system involuntary muscle" EXACT []
synonym: "respiratory system non-striated muscle" EXACT []
synonym: "respiratory system smooth muscle tissue" EXACT []
synonym: "smooth muscle of apparatus respiratorius" EXACT []
synonym: "smooth muscle of respiratory system" EXACT []
synonym: "smooth muscle tissue of apparatus respiratorius" EXACT []
synonym: "smooth muscle tissue of respiratory system" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0004226
name: gastrointestinal system smooth muscle
def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." []
synonym: "digestive system involuntary muscle" EXACT []
synonym: "digestive system non-striated muscle" EXACT []
synonym: "digestive system smooth muscle" EXACT []
synonym: "digestive system smooth muscle tissue" EXACT []
synonym: "gastrointestinal system involuntary muscle" EXACT []
synonym: "gastrointestinal system non-striated muscle" EXACT []
synonym: "gastrointestinal system smooth muscle tissue" EXACT []
synonym: "involuntary muscle of digestive system" EXACT []
synonym: "involuntary muscle of gastrointestinal system" EXACT []
synonym: "non-striated muscle of digestive system" EXACT []
synonym: "non-striated muscle of gastrointestinal system" EXACT []
synonym: "smooth muscle of digestive system" EXACT []
synonym: "smooth muscle of gastrointestinal system" EXACT []
synonym: "smooth muscle tissue of digestive system" EXACT []
synonym: "smooth muscle tissue of gastrointestinal system" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004227
name: kidney pelvis smooth muscle
def: "the smooth muscle tissue surrounding the urothelium of the kidney pelvis" []
synonym: "kidney pelvis smooth muscle" EXACT []
synonym: "pelvic smooth muscle" RELATED []
synonym: "renal pelvis smooth muscle" EXACT []
synonym: "smooth muscle tissue of renal pelvis" EXACT []
is_a: UBERON:0009919 ! ureter smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis

[Term]
id: UBERON:0004228
name: urinary bladder smooth muscle
def: "A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition]." []
synonym: "bladder involuntary muscle" EXACT []
synonym: "bladder non-striated muscle" EXACT []
synonym: "bladder smooth muscle" EXACT []
synonym: "bladder smooth muscle tissue" EXACT []
synonym: "involuntary muscle of bladder" EXACT []
synonym: "involuntary muscle of urinary bladder" EXACT []
synonym: "non-striated muscle of bladder" EXACT []
synonym: "non-striated muscle of urinary bladder" EXACT []
synonym: "smooth muscle layer of bladder" RELATED []
synonym: "smooth muscle of bladder" EXACT []
synonym: "smooth muscle of urinary bladder" EXACT []
synonym: "smooth muscle tissue of bladder" EXACT []
synonym: "smooth muscle tissue of urinary bladder" EXACT []
synonym: "urinary bladder involuntary muscle" EXACT []
synonym: "urinary bladder muscle" EXACT []
synonym: "urinary bladder non-striated muscle" EXACT []
synonym: "urinary bladder smooth muscle tissue" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: UBERON:0004229
name: urinary bladder trigone smooth muscle
def: "A portion of smooth muscle tissue that is part of a trigone of urinary bladder [Automatically generated definition]." []
synonym: "deep trigone involuntary muscle" EXACT []
synonym: "deep trigone non-striated muscle" EXACT []
synonym: "deep trigone smooth muscle" EXACT []
synonym: "deep trigone smooth muscle tissue" EXACT []
synonym: "involuntary muscle of deep trigone" EXACT []
synonym: "involuntary muscle of Lieutaud's trigone" EXACT []
synonym: "involuntary muscle of trigone of bladder" EXACT []
synonym: "involuntary muscle of trigone of urinary bladder" EXACT []
synonym: "involuntary muscle of urinary bladder trigone" EXACT []
synonym: "involuntary muscle of vesical trigone" EXACT []
synonym: "Lieutaud's trigone involuntary muscle" EXACT []
synonym: "Lieutaud's trigone non-striated muscle" EXACT []
synonym: "Lieutaud's trigone smooth muscle" EXACT []
synonym: "Lieutaud's trigone smooth muscle tissue" EXACT []
synonym: "non-striated muscle of deep trigone" EXACT []
synonym: "non-striated muscle of Lieutaud's trigone" EXACT []
synonym: "non-striated muscle of trigone of bladder" EXACT []
synonym: "non-striated muscle of trigone of urinary bladder" EXACT []
synonym: "non-striated muscle of urinary bladder trigone" EXACT []
synonym: "non-striated muscle of vesical trigone" EXACT []
synonym: "smooth muscle of deep trigone" EXACT []
synonym: "smooth muscle of Lieutaud's trigone" EXACT []
synonym: "smooth muscle of trigone of bladder" EXACT []
synonym: "smooth muscle of trigone of urinary bladder" EXACT []
synonym: "smooth muscle of urinary bladder trigone" EXACT []
synonym: "smooth muscle of vesical trigone" EXACT []
synonym: "smooth muscle tissue of deep trigone" EXACT []
synonym: "smooth muscle tissue of Lieutaud's trigone" EXACT []
synonym: "smooth muscle tissue of trigone of bladder" EXACT []
synonym: "smooth muscle tissue of trigone of urinary bladder" EXACT []
synonym: "smooth muscle tissue of urinary bladder trigone" EXACT []
synonym: "smooth muscle tissue of vesical trigone" EXACT []
synonym: "trigone of bladder involuntary muscle" EXACT []
synonym: "trigone of bladder non-striated muscle" EXACT []
synonym: "trigone of bladder smooth muscle" EXACT []
synonym: "trigone of bladder smooth muscle tissue" EXACT []
synonym: "trigone of urinary bladder involuntary muscle" EXACT []
synonym: "trigone of urinary bladder non-striated muscle" EXACT []
synonym: "trigone of urinary bladder smooth muscle" EXACT []
synonym: "trigone of urinary bladder smooth muscle tissue" EXACT []
synonym: "urinary bladder trigone involuntary muscle" EXACT []
synonym: "urinary bladder trigone muscle" EXACT []
synonym: "urinary bladder trigone non-striated muscle" EXACT []
synonym: "urinary bladder trigone smooth muscle tissue" EXACT []
synonym: "vesical trigone involuntary muscle" EXACT []
synonym: "vesical trigone non-striated muscle" EXACT []
synonym: "vesical trigone smooth muscle" EXACT []
synonym: "vesical trigone smooth muscle tissue" EXACT []
is_a: UBERON:0004228 ! urinary bladder smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder
relationship: part_of UBERON:0001257 ! trigone of urinary bladder

[Term]
id: UBERON:0004230
name: urinary bladder neck smooth muscle
def: "A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition]." []
synonym: "bladder neck involuntary muscle" EXACT []
synonym: "bladder neck non-striated muscle" EXACT []
synonym: "bladder neck smooth muscle" EXACT []
synonym: "bladder neck smooth muscle tissue" EXACT []
synonym: "involuntary muscle of bladder neck" EXACT []
synonym: "involuntary muscle of neck of bladder" EXACT []
synonym: "involuntary muscle of neck of urinary bladder" EXACT []
synonym: "involuntary muscle of urinary bladder neck" EXACT []
synonym: "involuntary muscle of vesical neck" EXACT []
synonym: "neck of bladder involuntary muscle" EXACT []
synonym: "neck of bladder non-striated muscle" EXACT []
synonym: "neck of bladder smooth muscle" EXACT []
synonym: "neck of bladder smooth muscle tissue" EXACT []
synonym: "neck of urinary bladder involuntary muscle" EXACT []
synonym: "neck of urinary bladder non-striated muscle" EXACT []
synonym: "neck of urinary bladder smooth muscle" EXACT []
synonym: "neck of urinary bladder smooth muscle tissue" EXACT []
synonym: "non-striated muscle of bladder neck" EXACT []
synonym: "non-striated muscle of neck of bladder" EXACT []
synonym: "non-striated muscle of neck of urinary bladder" EXACT []
synonym: "non-striated muscle of urinary bladder neck" EXACT []
synonym: "non-striated muscle of vesical neck" EXACT []
synonym: "smooth muscle of bladder neck" EXACT []
synonym: "smooth muscle of neck of bladder" EXACT []
synonym: "smooth muscle of neck of urinary bladder" EXACT []
synonym: "smooth muscle of urinary bladder neck" EXACT []
synonym: "smooth muscle of vesical neck" EXACT []
synonym: "smooth muscle tissue of bladder neck" EXACT []
synonym: "smooth muscle tissue of neck of bladder" EXACT []
synonym: "smooth muscle tissue of neck of urinary bladder" EXACT []
synonym: "smooth muscle tissue of urinary bladder neck" EXACT []
synonym: "smooth muscle tissue of vesical neck" EXACT []
synonym: "trigonal muscle" EXACT []
synonym: "trigonal muscle of urinary bladder" EXACT []
synonym: "urinary bladder neck involuntary muscle" EXACT []
synonym: "urinary bladder neck muscle" EXACT []
synonym: "urinary bladder neck non-striated muscle" EXACT []
synonym: "urinary bladder neck smooth muscle tissue" EXACT []
synonym: "vesical neck involuntary muscle" EXACT []
synonym: "vesical neck non-striated muscle" EXACT []
synonym: "vesical neck smooth muscle" EXACT []
synonym: "vesical neck smooth muscle tissue" EXACT []
is_a: UBERON:0004228 ! urinary bladder smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001258 ! neck of urinary bladder
relationship: part_of UBERON:0001258 ! neck of urinary bladder

[Term]
id: UBERON:0004231
name: anal region smooth muscle
def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." []
synonym: "anal part of perineum involuntary muscle" EXACT []
synonym: "anal part of perineum non-striated muscle" EXACT []
synonym: "anal part of perineum smooth muscle" EXACT []
synonym: "anal part of perineum smooth muscle tissue" EXACT []
synonym: "anal region involuntary muscle" EXACT []
synonym: "anal region non-striated muscle" EXACT []
synonym: "anal region smooth muscle tissue" EXACT []
synonym: "anal triangle involuntary muscle" EXACT []
synonym: "anal triangle non-striated muscle" EXACT []
synonym: "anal triangle smooth muscle" EXACT []
synonym: "anal triangle smooth muscle tissue" EXACT []
synonym: "involuntary muscle of anal part of perineum" EXACT []
synonym: "involuntary muscle of anal region" EXACT []
synonym: "involuntary muscle of anal triangle" EXACT []
synonym: "non-striated muscle of anal part of perineum" EXACT []
synonym: "non-striated muscle of anal region" EXACT []
synonym: "non-striated muscle of anal triangle" EXACT []
synonym: "smooth muscle of anal part of perineum" EXACT []
synonym: "smooth muscle of anal region" EXACT []
synonym: "smooth muscle of anal triangle" EXACT []
synonym: "smooth muscle tissue of anal part of perineum" EXACT []
synonym: "smooth muscle tissue of anal region" EXACT []
synonym: "smooth muscle tissue of anal triangle" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001353 ! anal region
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0004232
name: lymphatic vessel smooth muscle
def: "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." []
synonym: "involuntary muscle of lymph vessel" EXACT []
synonym: "involuntary muscle of lymphatic vessel" EXACT []
synonym: "lymph vessel involuntary muscle" EXACT []
synonym: "lymph vessel non-striated muscle" EXACT []
synonym: "lymph vessel smooth muscle" EXACT []
synonym: "lymph vessel smooth muscle tissue" EXACT []
synonym: "lymphatic vessel involuntary muscle" EXACT []
synonym: "lymphatic vessel non-striated muscle" EXACT []
synonym: "lymphatic vessel smooth muscle tissue" EXACT []
synonym: "non-striated muscle of lymph vessel" EXACT []
synonym: "non-striated muscle of lymphatic vessel" EXACT []
synonym: "smooth muscle of lymph vessel" EXACT []
synonym: "smooth muscle of lymphatic vessel" EXACT []
synonym: "smooth muscle tissue of lymph vessel" EXACT []
synonym: "smooth muscle tissue of lymphatic vessel" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: part_of UBERON:0001473 ! lymphatic vessel

[Term]
id: UBERON:0004233
name: lower respiratory tract smooth muscle
def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." []
synonym: "involuntary muscle of lower respiratory tract" EXACT []
synonym: "lower respiratory tract involuntary muscle" EXACT []
synonym: "lower respiratory tract non-striated muscle" EXACT []
synonym: "lower respiratory tract smooth muscle tissue" EXACT []
synonym: "non-striated muscle of lower respiratory tract" EXACT []
synonym: "smooth muscle of lower respiratory tract" EXACT []
synonym: "smooth muscle tissue of lower respiratory tract" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0004225 ! respiratory system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0004234
name: iris smooth muscle
def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." []
synonym: "involuntary muscle of iris" EXACT []
synonym: "iridial smooth muscle" EXACT []
synonym: "iris involuntary muscle" EXACT []
synonym: "iris non-striated muscle" EXACT []
synonym: "iris smooth muscle tissue" EXACT []
synonym: "non-striated muscle of iris" EXACT []
synonym: "smooth muscle of iris" EXACT []
synonym: "smooth muscle tissue of iris" EXACT []
is_a: UBERON:0003386 ! smooth muscle of eye
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001606 ! muscle of iris
relationship: part_of UBERON:0001769 ! iris

[Term]
id: UBERON:0004235
name: mammary gland smooth muscle
def: "A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition]." []
synonym: "smooth muscle tissue of mammary gland" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland

[Term]
id: UBERON:0004236
name: arteriole smooth muscle
def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." []
is_a: UBERON:0004237 ! blood vessel smooth muscle
is_a: UBERON:0004695 ! arterial system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001980 ! arteriole
relationship: part_of UBERON:0001980 ! arteriole

[Term]
id: UBERON:0004237
name: blood vessel smooth muscle
def: "smooth muscle found within, and composing the majority of the wall of blood vessels." []
synonym: "blood vessel involuntary muscle" EXACT []
synonym: "blood vessel non-striated muscle" EXACT []
synonym: "blood vessel smooth muscle tissue" EXACT []
synonym: "involuntary muscle of blood vessel" EXACT []
synonym: "non-striated muscle of blood vessel" EXACT []
synonym: "smooth muscle of blood vessel" EXACT []
synonym: "smooth muscle tissue of blood vessel" EXACT []
synonym: "vascular smooth muscle" EXACT []
synonym: "vascular smooth muscle tissue" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0004238
name: spleen smooth muscle
def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." []
synonym: "involuntary muscle of spleen" EXACT []
synonym: "non-striated muscle of spleen" EXACT []
synonym: "smooth muscle of spleen" EXACT []
synonym: "smooth muscle tissue of spleen" EXACT []
synonym: "spleen involuntary muscle" EXACT []
synonym: "spleen non-striated muscle" EXACT []
synonym: "spleen smooth muscle tissue" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0004239
name: small intestine smooth muscle
def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." []
synonym: "involuntary muscle of small bowel" EXACT []
synonym: "involuntary muscle of small intestine" EXACT []
synonym: "non-striated muscle of small bowel" EXACT []
synonym: "non-striated muscle of small intestine" EXACT []
synonym: "small bowel involuntary muscle" EXACT []
synonym: "small bowel non-striated muscle" EXACT []
synonym: "small bowel smooth muscle" EXACT []
synonym: "small bowel smooth muscle tissue" EXACT []
synonym: "small intestine involuntary muscle" EXACT []
synonym: "small intestine non-striated muscle" EXACT []
synonym: "small intestine smooth muscle tissue" EXACT []
synonym: "smooth muscle of small bowel" EXACT []
synonym: "smooth muscle of small intestine" EXACT []
synonym: "smooth muscle tissue of small bowel" EXACT []
synonym: "smooth muscle tissue of small intestine" EXACT []
is_a: UBERON:0004221 ! intestine smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0004240
name: gall bladder smooth muscle
def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." []
synonym: "biliary smooth muscle" RELATED []
synonym: "gall bladder involuntary muscle" EXACT []
synonym: "gall bladder non-striated muscle" EXACT []
synonym: "gall bladder smooth muscle tissue" EXACT []
synonym: "gallbladder involuntary muscle" EXACT []
synonym: "gallbladder non-striated muscle" EXACT []
synonym: "gallbladder smooth muscle" EXACT []
synonym: "gallbladder smooth muscle tissue" EXACT []
synonym: "involuntary muscle of gall bladder" EXACT []
synonym: "involuntary muscle of gallbladder" EXACT []
synonym: "non-striated muscle of gall bladder" EXACT []
synonym: "non-striated muscle of gallbladder" EXACT []
synonym: "smooth muscle of gall bladder" EXACT []
synonym: "smooth muscle of gallbladder" EXACT []
synonym: "smooth muscle tissue of gall bladder" EXACT []
synonym: "smooth muscle tissue of gallbladder" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: UBERON:0004242
name: bronchus smooth muscle
def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." []
synonym: "bronchi involuntary muscle" EXACT []
synonym: "bronchi non-striated muscle" EXACT []
synonym: "bronchi smooth muscle" EXACT []
synonym: "bronchi smooth muscle tissue" EXACT []
synonym: "bronchial smooth muscle" RELATED []
synonym: "bronchial trunk involuntary muscle" EXACT []
synonym: "bronchial trunk non-striated muscle" EXACT []
synonym: "bronchial trunk smooth muscle" EXACT []
synonym: "bronchial trunk smooth muscle tissue" EXACT []
synonym: "bronchus involuntary muscle" EXACT []
synonym: "bronchus non-striated muscle" EXACT []
synonym: "bronchus smooth muscle tissue" EXACT []
synonym: "involuntary muscle of bronchi" EXACT []
synonym: "involuntary muscle of bronchial trunk" EXACT []
synonym: "involuntary muscle of bronchus" EXACT []
synonym: "non-striated muscle of bronchi" EXACT []
synonym: "non-striated muscle of bronchial trunk" EXACT []
synonym: "non-striated muscle of bronchus" EXACT []
synonym: "smooth muscle of bronchi" EXACT []
synonym: "smooth muscle of bronchial trunk" EXACT []
synonym: "smooth muscle of bronchus" EXACT []
synonym: "smooth muscle tissue of bronchi" EXACT []
synonym: "smooth muscle tissue of bronchial trunk" EXACT []
synonym: "smooth muscle tissue of bronchus" EXACT []
is_a: UBERON:0004233 ! lower respiratory tract smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0004243
name: prostate gland smooth muscle
def: "A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition]." []
synonym: "involuntary muscle of prostate" EXACT []
synonym: "involuntary muscle of prostate gland" EXACT []
synonym: "muscular tissue of prostate" EXACT []
synonym: "non-striated muscle of prostate" EXACT []
synonym: "non-striated muscle of prostate gland" EXACT []
synonym: "prostate gland involuntary muscle" EXACT []
synonym: "prostate gland non-striated muscle" EXACT []
synonym: "prostate gland smooth muscle tissue" EXACT []
synonym: "prostate involuntary muscle" EXACT []
synonym: "prostate non-striated muscle" EXACT []
synonym: "prostate smooth muscle" EXACT []
synonym: "prostate smooth muscle tissue" EXACT []
synonym: "smooth muscle of prostate" EXACT []
synonym: "smooth muscle of prostate gland" EXACT []
synonym: "smooth muscle tissue of prostate" EXACT []
synonym: "smooth muscle tissue of prostate gland" EXACT []
synonym: "substantia muscularis prostatae" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0008715 ! muscle tissue of prostate
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0004245
name: oviduct smooth muscle
def: "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." []
synonym: "fallopian tube involuntary muscle" EXACT []
synonym: "fallopian tube non-striated muscle" EXACT []
synonym: "fallopian tube smooth muscle" EXACT []
synonym: "fallopian tube smooth muscle tissue" EXACT []
synonym: "involuntary muscle of fallopian tube" EXACT []
synonym: "non-striated muscle of fallopian tube" EXACT []
synonym: "smooth muscle of fallopian tube" EXACT []
synonym: "smooth muscle tissue of fallopian tube" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0004246
name: outflow tract smooth muscle
def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." []
synonym: "involuntary muscle of outflow tract" EXACT []
synonym: "non-striated muscle of outflow tract" EXACT []
synonym: "outflow tract involuntary muscle" EXACT []
synonym: "outflow tract non-striated muscle" EXACT []
synonym: "outflow tract smooth muscle tissue" EXACT []
synonym: "smooth muscle of outflow tract" EXACT []
synonym: "smooth muscle tissue of outflow tract" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0004247
name: bone of dorsum
def: "A bone that is part of the dorsal region of an animal." []
synonym: "back bone" RELATED []
synonym: "bone of back" RELATED []
synonym: "dorsal region bone" RELATED []
is_a: UBERON:0001474 ! bone element
is_a: UBERON:0005174 ! dorsal region element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0004248
name: pedal digit bone
def: "A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids." []
synonym: "bone of digit of foot" EXACT []
synonym: "digit of foot bone" EXACT []
synonym: "digital bone of foot" EXACT []
synonym: "digital bone of pes" EXACT []
synonym: "digitus pedis bone" EXACT []
synonym: "digitus pedis bone organ" EXACT []
synonym: "foot digit bone" EXACT []
synonym: "foot digit bone" NARROW []
synonym: "foot digit bone organ" EXACT []
synonym: "hind limb digit bone" EXACT []
synonym: "toe bone" EXACT []
synonym: "toe bone organ" EXACT []
is_a: UBERON:0012359 ! pedal digitopodium bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:5101466 ! pedal digit digitopodial skeleton

[Term]
id: UBERON:0004249
name: manual digit bone
def: "A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids." []
synonym: "digital bone of hand" EXACT []
synonym: "digital bone of manus" EXACT []
synonym: "finger bone" EXACT []
synonym: "fore limb digit bone" EXACT []
synonym: "hand digit bone" EXACT []
synonym: "hand digit bone" NARROW []
is_a: UBERON:0012358 ! manual digitopodium bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:5102389 ! manual digit digitopodial skeleton

[Term]
id: UBERON:0004250
name: upper arm bone
def: "A bone that is part of a forelimb stylopod [Automatically generated definition]." []
synonym: "humerus" NARROW []
is_a: UBERON:0003460 ! arm bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0004252
name: hindlimb stylopod muscle
def: "Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition]." []
synonym: "muscle of thigh" EXACT []
synonym: "thigh muscle" EXACT []
synonym: "upper leg muscle" EXACT []
is_a: UBERON:0001383 ! muscle of leg
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0004463 ! musculature of hindlimb stylopod

[Term]
id: UBERON:0004253
name: skin muscle
def: "Any muscle organ that is part of a skin of body [Automatically generated definition]." []
synonym: "integumental system muscle" EXACT []
synonym: "muscle of integumental system" EXACT []
synonym: "muscle organ of skin" EXACT []
synonym: "skin muscle organ" EXACT []
is_a: UBERON:0001630 ! muscle organ
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0002416 ! integumental system
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0004255
name: forelimb stylopod muscle
def: "Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition]." []
synonym: "muscle of arm" RELATED []
synonym: "muscle of upper arm" EXACT []
synonym: "skeletal muscle of upper arm" RELATED []
synonym: "upper arm muscle" EXACT []
synonym: "wing stylopod muscle" NARROW []
is_a: UBERON:0001499 ! muscle of arm
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0014791 ! musculature of forelimb stylopod

[Term]
id: UBERON:0004257
name: upper leg blood vessel
def: "A blood vessel that is part of a hindlimb stylopod [Automatically generated definition]." []
synonym: "blood vessel of stylopod of hind limb" EXACT []
synonym: "blood vessel of stylopod of hindlimb" EXACT []
synonym: "blood vessel of thigh" EXACT []
synonym: "blood vessel of upper leg" EXACT []
synonym: "hind limb stylopod blood vessel" EXACT []
synonym: "hindlimb stylopod blood vessel" EXACT []
synonym: "thigh blood vessel" EXACT []
is_a: UBERON:0003503 ! leg blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0004258
name: back blood vessel
def: "A blood vessel that is part of a back [Automatically generated definition]." []
synonym: "blood vessel of back" EXACT []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0004260
name: upper arm blood vessel
def: "A blood vessel that is part of a forelimb stylopod [Automatically generated definition]." []
synonym: "forelimb stylopod blood vessel" EXACT []
is_a: UBERON:0003507 ! arm blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0004262
name: upper leg skin
def: "A zone of skin that is part of a hindlimb stylopod [Automatically generated definition]." []
synonym: "hind limb stylopod skin" EXACT []
synonym: "hindlimb stylopod skin" EXACT []
synonym: "inferior member stylopod skin" EXACT []
synonym: "lower extremity stylopod skin" EXACT []
synonym: "Proximal segment of free lower limb skin" EXACT []
synonym: "skin of hind limb stylopod" EXACT []
synonym: "skin of hindlimb stylopod" EXACT []
synonym: "skin of inferior member stylopod" EXACT []
synonym: "skin of lower extremity stylopod" EXACT []
synonym: "skin of Proximal segment of free lower limb" EXACT []
synonym: "skin of stylopod of hind limb" EXACT []
synonym: "skin of stylopod of hindlimb" EXACT []
synonym: "skin of stylopod of inferior member" EXACT []
synonym: "skin of stylopod of lower extremity" EXACT []
synonym: "skin of stylopod of lower limb" EXACT []
synonym: "skin of thigh" EXACT []
synonym: "skin of upper leg" EXACT []
synonym: "stylopod of hind limb skin" EXACT []
synonym: "stylopod of hindlimb skin" EXACT []
synonym: "stylopod of inferior member skin" EXACT []
synonym: "stylopod of lower extremity skin" EXACT []
synonym: "stylopod of lower limb skin" EXACT []
synonym: "thigh skin" EXACT []
is_a: UBERON:0001511 ! skin of leg
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0004263
name: upper arm skin
def: "A zone of skin that is part of a forelimb stylopod [Automatically generated definition]." []
synonym: "arm stylopod skin" EXACT []
synonym: "brachial region stylopod skin" EXACT []
synonym: "Proximal segment of free upper limb skin" EXACT []
synonym: "proximal segment of free upper limb stylopod skin" EXACT []
synonym: "skin of arm stylopod" EXACT []
synonym: "skin of brachial region stylopod" EXACT []
synonym: "skin of Proximal segment of free upper limb" EXACT []
synonym: "skin of proximal segment of free upper limb stylopod" EXACT []
synonym: "skin of stylopod of arm" EXACT []
synonym: "skin of stylopod of brachial region" EXACT []
synonym: "skin of stylopod of proximal segment of free upper limb" EXACT []
synonym: "skin of upper arm" EXACT []
synonym: "stylopod of arm skin" EXACT []
synonym: "stylopod of brachial region skin" EXACT []
synonym: "stylopod of proximal segment of free upper limb skin" EXACT []
is_a: UBERON:0002427 ! arm skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0004265
name: outflow tract myocardium
def: "A myocardium that is part of a outflow tract [Automatically generated definition]." []
synonym: "cardiac muscle of outflow tract" EXACT []
synonym: "heart muscle of outflow tract" EXACT []
synonym: "heart myocardium of outflow tract" EXACT []
synonym: "muscle of heart of outflow tract" EXACT []
synonym: "myocardium of outflow tract" EXACT []
synonym: "outflow tract cardiac muscle" EXACT []
synonym: "outflow tract heart muscle" EXACT []
synonym: "outflow tract heart myocardium" EXACT []
synonym: "outflow tract muscle of heart" EXACT []
is_a: UBERON:0002349 ! myocardium
intersection_of: UBERON:0002349 ! myocardium
intersection_of: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0004266
name: upper leg connective tissue
def: "A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition]." []
is_a: UBERON:0003569 ! leg connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0004267
name: back connective tissue
def: "A portion of connective tissue that is part of a back [Automatically generated definition]." []
synonym: "mesenchyne of back" RELATED []
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0004269
name: upper arm connective tissue
def: "A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition]." []
is_a: UBERON:0003573 ! arm connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0004271
name: outflow tract pericardium
def: "A pericardium that is part of a outflow tract [Automatically generated definition]." []
synonym: "pericardium of outflow tract" EXACT []
is_a: UBERON:0002407 ! pericardium
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002407 ! pericardium
intersection_of: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0004273
name: cartilaginous joint suture
def: "A cranial suture that is part of a cartilaginous joint [Automatically generated definition]." []
synonym: "articulatio cartilaginea cranial suture" EXACT []
synonym: "articulatio cartilaginea cranial sutures" EXACT []
synonym: "articulatio cartilaginea cranial sutures set" EXACT []
synonym: "articulatio cartilaginea cranium suture" EXACT []
synonym: "articulatio cartilaginea suture of cranium" EXACT []
synonym: "cartilaginous joint cranial suture" EXACT []
synonym: "cartilaginous joint cranial sutures" EXACT []
synonym: "cartilaginous joint cranial sutures set" EXACT []
synonym: "cartilaginous joint cranium suture" EXACT []
synonym: "cartilaginous joint suture of cranium" EXACT []
synonym: "cranial suture of articulatio cartilaginea" EXACT []
synonym: "cranial suture of cartilaginous joint" EXACT []
synonym: "cranial sutures of articulatio cartilaginea" EXACT []
synonym: "cranial sutures of cartilaginous joint" EXACT []
synonym: "cranial sutures set of articulatio cartilaginea" EXACT []
synonym: "cranial sutures set of cartilaginous joint" EXACT []
synonym: "cranium suture of articulatio cartilaginea" EXACT []
synonym: "cranium suture of cartilaginous joint" EXACT []
synonym: "suture of cranium of articulatio cartilaginea" EXACT []
synonym: "suture of cranium of cartilaginous joint" EXACT []
is_a: UBERON:0003685 ! cranial suture
intersection_of: UBERON:0003685 ! cranial suture
intersection_of: part_of UBERON:0002213 ! cartilaginous joint
relationship: part_of UBERON:0002213 ! cartilaginous joint

[Term]
id: UBERON:0004274
name: lateral ventricle choroid plexus epithelium
def: "A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition]." []
synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle" EXACT []
synonym: "chorioid plexus of cerebral hemisphere epithelium of lateral ventricle" EXACT []
synonym: "choroid plexus epithelial tissue of lateral ventricle" EXACT []
synonym: "choroid plexus epithelium of lateral ventricle" EXACT []
synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT []
synonym: "epithelial tissue of choroid plexus of lateral ventricle" EXACT []
synonym: "epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT []
synonym: "epithelium of choroid plexus of lateral ventricle" EXACT []
synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT []
synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT []
synonym: "lateral ventricle choroid plexus epithelial tissue" EXACT []
synonym: "lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT []
synonym: "lateral ventricle epithelial tissue of choroid plexus" EXACT []
synonym: "lateral ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT []
synonym: "lateral ventricle epithelium of choroid plexus" EXACT []
is_a: UBERON:0003911 ! choroid plexus epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002307 ! choroid plexus of lateral ventricle
relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle

[Term]
id: UBERON:0004276
name: fourth ventricle choroid plexus epithelium
def: "A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition]." []
synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle" EXACT []
synonym: "chorioid plexus of cerebral hemisphere epithelium of fourth ventricle" EXACT []
synonym: "choroid plexus epithelial tissue of fourth ventricle" EXACT []
synonym: "choroid plexus epithelium of fourth ventricle" EXACT []
synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT []
synonym: "epithelial tissue of choroid plexus of fourth ventricle" EXACT []
synonym: "epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT []
synonym: "epithelium of choroid plexus of fourth ventricle" EXACT []
synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT []
synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT []
synonym: "fourth ventricle choroid plexus epithelial tissue" EXACT []
synonym: "fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT []
synonym: "fourth ventricle epithelial tissue of choroid plexus" EXACT []
synonym: "fourth ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT []
synonym: "fourth ventricle epithelium of choroid plexus" EXACT []
is_a: UBERON:0003911 ! choroid plexus epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003911 ! choroid plexus epithelium
intersection_of: part_of UBERON:0002422 ! fourth ventricle
relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle
relationship: part_of UBERON:0002422 ! fourth ventricle

[Term]
id: UBERON:0004277
name: eye muscle
def: "A muscle that is part of the eye region." []
is_a: UBERON:0001630 ! muscle organ
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0004288
name: skeleton
def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." []
synonym: "set of all bones" EXACT []
synonym: "set of bones of body" EXACT []
is_a: UBERON:0034925 ! anatomical collection
disjoint_from: UBERON:0004770 ! articular system
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0004290
name: dermomyotome
def: "The bilaminar epithelium formed from the myotome and dermatome." []
synonym: "dermamyotome" RELATED []
synonym: "dermomyotomes" RELATED []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0012275 ! meso-epithelium
is_a: UBERON:0016888 ! transitional anatomical structure
relationship: develops_from UBERON:0002329 ! somite

[Term]
id: UBERON:0004291
name: heart rudiment
def: "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." []
synonym: "heart cone" EXACT []
synonym: "rudimentary heart" EXACT []
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003084 ! heart primordium
relationship: develops_from UBERON:0004139 ! cardiogenic plate

[Term]
id: UBERON:0004294
name: glomerular capillary endothelium
def: "An endothelium that is part of a glomerular capillary." []
synonym: "renal glomerulus capillary endothelium" EXACT []
is_a: UBERON:0001915 ! endothelium of capillary
is_a: UBERON:0004189 ! glomerular endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0004212 ! glomerular capillary
relationship: part_of UBERON:0004212 ! glomerular capillary

[Term]
id: UBERON:0004296
name: respiratory system lymphatic vessel smooth muscle
def: "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." []
synonym: "smooth muscle of lymph vessel of respiratory system" EXACT []
is_a: UBERON:0004225 ! respiratory system smooth muscle
is_a: UBERON:0004232 ! lymphatic vessel smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003456 ! respiratory system lymphatic vessel
relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel

[Term]
id: UBERON:0004297
name: respiratory system blood vessel smooth muscle
def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." []
synonym: "smooth muscle tissue of blood vessel of respiratory system" EXACT []
is_a: UBERON:0004225 ! respiratory system smooth muscle
is_a: UBERON:0004237 ! blood vessel smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003504 ! respiratory system blood vessel
relationship: part_of UBERON:0003504 ! respiratory system blood vessel

[Term]
id: UBERON:0004340
name: allantois
def: "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG]." []
synonym: "allantoic bud" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0000162 ! cloaca

[Term]
id: UBERON:0004345
name: trophectoderm
def: "outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition" []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010303 ! extraembryonic epithelium
relationship: develops_from UBERON:0000085 ! morula
relationship: part_of UBERON:0005631 ! extraembryonic membrane

[Term]
id: UBERON:0004347
name: limb bud
def: "An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." []
synonym: "gemmae membrorum" RELATED []
synonym: "limb buds" EXACT []
synonym: "limbbud" EXACT []
is_a: UBERON:0004357 ! paired limb/fin bud

[Term]
id: UBERON:0004348
name: optic eminence
def: "The embryonic structure that gives rise to the corneal ectoderm" []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0006598 ! presumptive structure

[Term]
id: UBERON:0004356
name: apical ectodermal ridge
def: "multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." []
synonym: "AER" RELATED []
synonym: "apical epidermal ridge" EXACT []
synonym: "crista ectodermalis apicalis" RELATED []
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0004357 ! paired limb/fin bud

[Term]
id: UBERON:0004357
name: paired limb/fin bud
def: "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." []
synonym: "limb - fin bud" EXACT []
synonym: "paired appendage bud" EXACT []
synonym: "paired limb/fin bud" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003102 ! surface structure
is_a: UBERON:0006598 ! presumptive structure
relationship: has_part UBERON:0004356 ! apical ectodermal ridge
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0004362
name: pharyngeal arch 1
def: "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries" []
synonym: "1st arch" RELATED []
synonym: "1st pharyngeal arch" EXACT []
synonym: "1st visceral arch" RELATED []
synonym: "arcus pharyngeus primus" RELATED []
synonym: "branchial arch 1" EXACT []
synonym: "first branchial arch" EXACT []
synonym: "first pharyngeal arch" EXACT []
synonym: "first visceral arch" EXACT []
synonym: "mandibular arch" EXACT []
synonym: "visceral arch 1" EXACT []
is_a: UBERON:0002539 ! pharyngeal arch

[Term]
id: UBERON:0004363
name: pharyngeal arch artery
def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]" []
synonym: "a. arcuum pharyngeorum" RELATED []
synonym: "aortic arch" EXACT []
synonym: "aortic arch artery" RELATED []
synonym: "aortic arches" EXACT []
synonym: "arteriae arcuum pharyngeorum" RELATED []
synonym: "branchial aortic arches" EXACT []
synonym: "branchial aortic arches" RELATED []
synonym: "branchial arch artery" EXACT []
synonym: "embryonic aortic arch artery" EXACT []
synonym: "PAA" EXACT []
synonym: "pharyngeal arch arteries" RELATED []
synonym: "pharyngeal arch artery" EXACT []
synonym: "pharyngeal arch artery" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003469 ! respiratory system artery
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015787 ! upper respiratory conduit
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0007303 ! pharyngeal vasculature

[Term]
id: UBERON:0004370
name: anterior limiting lamina of cornea
def: "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." []
synonym: "anterior elastic lamina" EXACT []
synonym: "anterior limiting lamina" EXACT []
synonym: "anterior limiting lamina of cornea" EXACT []
synonym: "anterior limiting membrane" RELATED []
synonym: "Bowman's anterior elastic lamina" EXACT []
synonym: "Bowman's layer" EXACT []
synonym: "Bowman's membrane" EXACT []
synonym: "lamina limitans anterior (cornea)" EXACT []
synonym: "lamina limitans anterior corneae" EXACT []
synonym: "Reichert's membrane" RELATED []
is_a: UBERON:0005769 ! basement membrane of epithelium
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: part_of UBERON:0000964 ! cornea

[Term]
id: UBERON:0004375
name: bone of free limb or fin
def: "A bone that is part of an appendage [Automatically generated definition]." []
synonym: "appendage bone" EXACT []
synonym: "bone of appendage" EXACT []
synonym: "bone of free segment of appendicular skeleton" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010740 ! bone of appendage girdle complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0004708 ! paired limb/fin
relationship: part_of UBERON:0004708 ! paired limb/fin
relationship: part_of UBERON:0011582 ! paired limb/fin skeleton

[Term]
id: UBERON:0004378
name: proximal metaphysis
def: "A metaphysis that is in the proximal side of a diaphysis." []
synonym: "proximal diaphyseal end of long bone" EXACT []
is_a: UBERON:0001438 ! metaphysis

[Term]
id: UBERON:0004381
name: skeleton of limb
def: "The collection of all skeletal elements in an individual limb." []
synonym: "free limb skeleton" EXACT []
synonym: "limb skeleton" EXACT []
synonym: "set of bones of limb" EXACT []
is_a: UBERON:0010712 ! limb skeleton subdivision
is_a: UBERON:0011582 ! paired limb/fin skeleton
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0004456
name: entire sense organ system
def: "Sum of all sensory systems in an organism." []
synonym: "sense organ system" EXACT []
is_a: UBERON:0000467 ! anatomical system

[Term]
id: UBERON:0004461
name: musculature of head
def: "Any collection of muscles that is part of a head [Automatically generated definition]." []
synonym: "head musculature" EXACT []
synonym: "muscle group of head" EXACT []
synonym: "muscles of head" EXACT []
synonym: "musculi capitis" EXACT []
synonym: "set of muscles of head" EXACT []
is_a: UBERON:0008229 ! craniocervical region musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000033 ! head
relationship: develops_from UBERON:0005253 ! head mesenchyme
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0013700 ! axial musculature

[Term]
id: UBERON:0004463
name: musculature of hindlimb stylopod
def: "Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition]." []
synonym: "muscle group of thigh" EXACT []
synonym: "musculature of thigh" EXACT []
synonym: "set of muscles of thigh" EXACT []
synonym: "thigh musculature" EXACT []
is_a: UBERON:0004466 ! musculature of leg
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0004464
name: musculature of thorax
def: "Any collection of muscles that is part of a thorax [Automatically generated definition]." []
synonym: "muscle group of thorax" EXACT []
synonym: "muscles of thorax" EXACT []
synonym: "musculi thoracis" EXACT []
synonym: "set of muscles of thorax" EXACT []
synonym: "thoracic musculature" EXACT []
is_a: UBERON:0004479 ! musculature of trunk
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0004466
name: musculature of leg
def: "Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition]." []
synonym: "leg muscle system" EXACT []
is_a: UBERON:0004482 ! musculature of lower limb
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0004469
name: musculature of back
def: "Any collection of muscles that is part of a back [Automatically generated definition]." []
synonym: "muscle group of back" EXACT []
synonym: "muscles of back" EXACT []
synonym: "musculi dorsi" EXACT []
synonym: "set of muscles of back" EXACT []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0004470
name: musculature of pelvic girdle
def: "Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]." []
synonym: "muscle group of pelvic girdle" EXACT []
synonym: "muscle group of pelvis" EXACT []
synonym: "muscular system of pelvis" RELATED []
synonym: "pelvic girdle muscle system" EXACT []
synonym: "pelvic girdle muscles" EXACT []
synonym: "pelvic girdle musculature" EXACT []
synonym: "set of muscles of pelvic girdle" EXACT []
synonym: "set of muscles of pelvis" RELATED []
is_a: UBERON:0004479 ! musculature of trunk
is_a: UBERON:0014792 ! musculature of pelvic complex
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0001271 ! pelvic girdle region

[Term]
id: UBERON:0004471
name: musculature of pectoral girdle
def: "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." []
synonym: "muscle group of pectoral girdle" EXACT []
synonym: "pectoral girdle muscles" EXACT []
synonym: "pectoral girdle musculature" EXACT []
synonym: "set of muscles of pectoral girdle" EXACT []
is_a: UBERON:0014793 ! musculature of pectoral complex
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0001421 ! pectoral girdle region

[Term]
id: UBERON:0004473
name: musculature of face
def: "Any collection of muscles that is part of a face." []
synonym: "entire facial musculature" EXACT []
synonym: "facial muscles" EXACT []
synonym: "muscle group of face" EXACT []
synonym: "musculi faciei" EXACT []
synonym: "set of facial muscles" RELATED []
synonym: "set of muscles of face" RELATED []
is_a: UBERON:0004461 ! musculature of head
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0004474
name: musculature of arm
def: "Any collection of muscles that is part of an arm [Automatically generated definition]." []
synonym: "arm muscle system" EXACT []
synonym: "arm musculature" EXACT []
synonym: "muscle group of arm" EXACT []
synonym: "set of muscles of arm" EXACT []
is_a: UBERON:0004481 ! musculature of upper limb
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0001460 ! arm
relationship: part_of UBERON:0001460 ! arm

[Term]
id: UBERON:0004475
name: musculature of hip
def: "The collection of muscles that form attachments to the hip skeleton." []
synonym: "hip musculature" EXACT []
synonym: "muscle group of hip" EXACT []
synonym: "set of muscles of hip" EXACT []
is_a: UBERON:0001015 ! musculature

[Term]
id: UBERON:0004476
name: musculature of shoulder
def: "The collection of muscles that form attachments to the shoulder skeleton." []
synonym: "muscle group of shoulder" EXACT []
synonym: "set of muscles of shoulder" EXACT []
is_a: UBERON:0001015 ! musculature

[Term]
id: UBERON:0004479
name: musculature of trunk
def: "Any collection of muscles that is part of a trunk [Automatically generated definition]." []
synonym: "muscle group of trunk" EXACT []
synonym: "muscular system of trunk" RELATED []
synonym: "set of muscles of trunk" EXACT []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0004480
name: musculature of limb
def: "Any collection of muscles that is part of a limb [Automatically generated definition]." []
synonym: "limb muscle system" EXACT []
synonym: "limb musculature" EXACT []
synonym: "muscle group of limb" EXACT []
synonym: "set of muscles of limb" EXACT []
is_a: UBERON:0007271 ! appendage musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0004481
name: musculature of upper limb
def: "Any collection of muscles that is part of a forelimb [Automatically generated definition]." []
synonym: "free upper limb musculature" EXACT []
synonym: "muscle group of free upper limb" EXACT []
synonym: "musculature of free upper limb" EXACT []
synonym: "set of muscles of free upper limb" EXACT []
is_a: UBERON:0004480 ! musculature of limb
is_a: UBERON:0007269 ! pectoral appendage musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0004482
name: musculature of lower limb
def: "Any collection of muscles that is part of a hindlimb [Automatically generated definition]." []
synonym: "free lower limb musculature" EXACT []
synonym: "muscle group of free lower limb" EXACT []
synonym: "musculature of free lower limb" EXACT []
synonym: "set of muscles of free lower limb" EXACT []
is_a: UBERON:0004480 ! musculature of limb
is_a: UBERON:0007270 ! pelvic appendage musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0004488
name: musculature of pes
def: "Any collection of muscles that is part of a foot [Automatically generated definition]." []
synonym: "foot musculature" EXACT []
synonym: "muscle group of foot" EXACT []
synonym: "musculature of foot" EXACT []
synonym: "set of muscles of foot" EXACT []
is_a: UBERON:0004482 ! musculature of lower limb
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0004489
name: musculature of manus
def: "Any collection of muscles that is part of a manus [Automatically generated definition]." []
synonym: "hand musculature" EXACT []
synonym: "muscle group of hand" EXACT []
synonym: "musculature of hand" EXACT []
synonym: "set of muscles of hand" EXACT []
is_a: UBERON:0004481 ! musculature of upper limb
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0004490
name: cardiac muscle tissue of atrium
def: "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." []
synonym: "atrial cardiac muscle tissue" EXACT []
synonym: "atrial heart muscle" EXACT []
synonym: "atrial myocardium" RELATED []
synonym: "cardiac atrium muscle" EXACT []
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002302 ! myocardium of atrium

[Term]
id: UBERON:0004491
name: cardiac muscle tissue of interatrial septum
def: "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." []
synonym: "interatrial septum cardiac muscle tissue" EXACT []
synonym: "interatrial septum heart muscle" EXACT []
synonym: "interatrial septum muscle" EXACT []
synonym: "interatrial septum myocardium" EXACT []
is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002085 ! interatrial septum
relationship: part_of UBERON:0002085 ! interatrial septum

[Term]
id: UBERON:0004492
name: cardiac muscle tissue of cardiac septum
def: "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." []
synonym: "cardiac septum cardiac muscle tissue" EXACT []
synonym: "cardiac septum heart muscle" EXACT []
synonym: "cardiac septum muscle" EXACT []
synonym: "cardiac septum myocardium" EXACT []
is_a: UBERON:0001133 ! cardiac muscle tissue
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002099 ! cardiac septum
relationship: part_of UBERON:0002099 ! cardiac septum

[Term]
id: UBERON:0004493
name: cardiac muscle tissue of myocardium
def: "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." []
is_a: UBERON:0001133 ! cardiac muscle tissue
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002349 ! myocardium
relationship: part_of UBERON:0002349 ! myocardium

[Term]
id: UBERON:0004510
name: skeletal muscle tissue of pectoralis major
def: "A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition]." []
synonym: "skeletal muscle tissue of pectoralis major muscle" RELATED []
is_a: UBERON:0003898 ! skeletal muscle tissue of trunk
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0002381 ! pectoralis major
relationship: part_of UBERON:0002381 ! pectoralis major

[Term]
id: UBERON:0004515
name: smooth muscle tissue of bronchiole
def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." []
synonym: "smooth muscle tissue of lobular bronchiole" EXACT []
is_a: UBERON:0004242 ! bronchus smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0002186 ! bronchiole

[Term]
id: UBERON:0004516
name: smooth muscle tissue of terminal bronchiole
def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." []
is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002187 ! terminal bronchiole
relationship: part_of UBERON:0002187 ! terminal bronchiole

[Term]
id: UBERON:0004517
name: smooth muscle tissue of respiratory bronchiole
def: "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]." []
is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002188 ! respiratory bronchiole
relationship: part_of UBERON:0002188 ! respiratory bronchiole

[Term]
id: UBERON:0004520
name: striated muscle tissue of prostate
def: "A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition]." []
is_a: UBERON:0001134 ! skeletal muscle tissue
is_a: UBERON:0008715 ! muscle tissue of prostate
intersection_of: UBERON:0002036 ! striated muscle tissue
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0004521
name: vasculature of muscle organ
def: "A vasculature that is part of a muscle organ [Automatically generated definition]." []
synonym: "muscular organ vasculature" EXACT []
is_a: UBERON:0004522 ! vasculature of musculoskeletal system
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0001630 ! muscle organ

[Term]
id: UBERON:0004522
name: vasculature of musculoskeletal system
def: "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002204 ! musculoskeletal system
relationship: part_of UBERON:0002204 ! musculoskeletal system

[Term]
id: UBERON:0004529
name: anatomical projection
def: "A projection or outgrowth of tissue from a larger body or organ." []
synonym: "anatomical process" BROAD []
synonym: "anatomical protrusion" RELATED []
synonym: "flange" NARROW []
synonym: "flanges" NARROW []
synonym: "lamella" NARROW []
synonym: "lamellae" NARROW []
synonym: "lamina" NARROW []
synonym: "laminae" NARROW []
synonym: "organ process" NARROW []
synonym: "papilla" NARROW []
synonym: "process" BROAD []
synonym: "process of organ" NARROW []
synonym: "processes" NARROW []
synonym: "processus" EXACT []
synonym: "projection" EXACT []
synonym: "projection" NARROW []
synonym: "projections" NARROW []
synonym: "protrusion" RELATED []
synonym: "ridge" NARROW []
synonym: "ridges" NARROW []
synonym: "shelf" NARROW []
synonym: "shelves" NARROW []
synonym: "spine" RELATED []
is_a: UBERON:0034768 ! morphological feature
relationship: part_of UBERON:0000062 ! organ

[Term]
id: UBERON:0004535
name: cardiovascular system
def: "Anatomical system that has as its parts the heart and blood vessels." []
synonym: "CV system" RELATED []
synonym: "Herz und Gefaesssystem" RELATED []
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: has_part UBERON:0000948 ! heart
intersection_of: has_part UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001009 ! circulatory system
relationship: has_part UBERON:0000948 ! heart
relationship: has_part UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001009 ! circulatory system

[Term]
id: UBERON:0004536
name: lymph vasculature
def: "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." []
synonym: "lymph vessels" RELATED []
synonym: "lymphatic trunks and ducts" EXACT []
synonym: "lymphatic vasculature" EXACT []
synonym: "lymphatic vessel network" EXACT []
synonym: "lymphatic vessels set" EXACT []
synonym: "set of lymphatic vessels" EXACT []
synonym: "trunci et ductus lymphatici" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: has_part UBERON:0002391 ! lymph
relationship: has_part UBERON:0002391 ! lymph
relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system

[Term]
id: UBERON:0004537
name: blood vasculature
def: "A vascular network consisting of blood vessels." []
synonym: "blood system" RELATED []
synonym: "blood vascular network" EXACT []
synonym: "blood vessel system" RELATED []
synonym: "blood vessels" RELATED []
synonym: "set of blood vessels" EXACT []
is_a: UBERON:0002049 ! vasculature
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0004544
name: epididymis epithelium
def: "the layer of secretory cells which lines the epididymis" []
synonym: "Epididymis epithelium" EXACT []
synonym: "epithelium of epididymis" EXACT []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0012275 ! meso-epithelium
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000485 ! simple columnar epithelium
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis

[Term]
id: UBERON:0004550
name: gastroesophageal sphincter
def: "the thick circular layer of smooth gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach" []
synonym: "cardiac sphincter" EXACT []
synonym: "cardiac sphincter" RELATED []
synonym: "constrictor cardiae" RELATED []
synonym: "esophageal sphincter" RELATED []
synonym: "esophageal sphincter%2c lower" RELATED []
synonym: "esophageal-cardiac junction" RELATED []
synonym: "esophagogastric junction" RELATED []
synonym: "gastro-esophageal junction" RELATED []
synonym: "gastro-esophageal sphincter" RELATED []
synonym: "gastro-oesophageal junction" RELATED []
synonym: "gastroesophageal junction" RELATED []
synonym: "gastroesophageal sphincter" EXACT []
synonym: "gastroesophageal sphincter" RELATED []
synonym: "gastroesophageal sphincter muscle" EXACT []
synonym: "inferior esophageal sphincter" EXACT []
synonym: "LES" RELATED []
synonym: "lower esophageal sphincter" RELATED []
is_a: UBERON:0011185 ! gastrointestinal sphincter
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0001162 ! cardia of stomach
relationship: part_of UBERON:0001162 ! cardia of stomach

[Term]
id: UBERON:0004552
name: digital artery
def: "An artery that is part of a digit [Automatically generated definition]." []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0003514 ! limb blood vessel
intersection_of: UBERON:0001637 ! artery
intersection_of: part_of UBERON:0002544 ! digit
relationship: part_of UBERON:0002544 ! digit

[Term]
id: UBERON:0004553
name: forelimb digital artery
def: "A digital artery that is part of a forelimb [Automatically generated definition]." []
synonym: "digital artery of manus" EXACT []
synonym: "forelimb digital arteries" EXACT []
synonym: "wing digital artery" NARROW []
is_a: UBERON:0003522 ! manual digit blood vessel
is_a: UBERON:0004552 ! digital artery
intersection_of: UBERON:0004552 ! digital artery
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0004554
name: hindlimb digital artery
def: "A digital artery that is part of a hindlimb [Automatically generated definition]." []
synonym: "digital artery of foot" EXACT []
synonym: "hindlimb digital arteries" EXACT []
is_a: UBERON:0003516 ! hindlimb blood vessel
is_a: UBERON:0004552 ! digital artery
intersection_of: UBERON:0004552 ! digital artery
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0004571
name: systemic arterial system
def: "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." []
synonym: "systemic arterial circulatory system" EXACT []
is_a: UBERON:0007798 ! vascular system
relationship: part_of UBERON:0004572 ! arterial system

[Term]
id: UBERON:0004572
name: arterial system
def: "The part of the cardiovascular system consisting of all arteries." []
is_a: UBERON:0007798 ! vascular system
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0004573
name: systemic artery
def: "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." []
synonym: "systemic arterial subtree" EXACT []
is_a: UBERON:0001637 ! artery
intersection_of: UBERON:0001637 ! artery
intersection_of: part_of UBERON:0004571 ! systemic arterial system
relationship: part_of UBERON:0004571 ! systemic arterial system

[Term]
id: UBERON:0004581
name: systemic venous system
def: "The part of the venous system that drains the general body tissues[Kardong]" []
synonym: "systemic venous circulatory system" EXACT []
is_a: UBERON:0002049 ! vasculature
relationship: part_of UBERON:0004582 ! venous system

[Term]
id: UBERON:0004582
name: venous system
def: "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." []
synonym: "vein system" EXACT []
is_a: UBERON:0007798 ! vascular system

[Term]
id: UBERON:0004590
name: sphincter muscle
def: "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." []
synonym: "circular muscle" RELATED []
synonym: "sphincter" EXACT []
is_a: UBERON:0001630 ! muscle organ

[Term]
id: UBERON:0004638
name: blood vessel endothelium
def: "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart" []
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0004639
name: renal afferent arteriole
def: "the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" []
synonym: "afferent arteriole" EXACT []
synonym: "afferent glomerular arteriole" EXACT []
synonym: "afferent glomerular arteriole of kidney" EXACT []
synonym: "arteriola glomerularis afferens" RELATED []
synonym: "arteriola glomerularis afferens renis" EXACT []
synonym: "kidney afferent arteriole" EXACT []
is_a: UBERON:0001980 ! arteriole
is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0001229 ! renal corpuscle

[Term]
id: UBERON:0004640
name: renal efferent arteriole
def: "the blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule" []
synonym: "arteriola glomerularis efferens capsulae renalis" RELATED []
synonym: "arteriola glomerularis efferens renis" EXACT []
synonym: "efferent arteriole" EXACT []
synonym: "efferent glomerular arteriole" EXACT []
synonym: "efferent glomerular arteriole of kidney" EXACT []
synonym: "kidney efferent arteriole" EXACT []
is_a: UBERON:0001980 ! arteriole
is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0001229 ! renal corpuscle

[Term]
id: UBERON:0004641
name: spleen capsule
def: "the connective tissue that surrounds the spleen" []
synonym: "capsula splenica" EXACT []
synonym: "capsule of spleen" EXACT []
synonym: "fibroelastic coat of spleen" EXACT []
synonym: "fibrous capsule of spleen" EXACT []
synonym: "Malpighian capsule" EXACT []
synonym: "splenic capsule" EXACT []
synonym: "tunica fibrosa (splen)(lien)" EXACT []
synonym: "tunica fibrosa splenica" EXACT []
is_a: UBERON:0003893 ! capsule
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003893 ! capsule
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0004645
name: urinary bladder urothelium
def: "The epithelial lining of the luminal space of the urinary bladder." []
synonym: "bladder transitional cell epithelium" EXACT []
synonym: "epithelium of bladder" RELATED []
synonym: "transitional epithelium" RELATED []
synonym: "transitional epithelium of urinary bladder" EXACT []
synonym: "urinary bladder transitional epithelium" EXACT []
synonym: "urothelium" BROAD []
synonym: "urothelium of urinary bladder" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000365 ! urothelium
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000365 ! urothelium
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001259 ! mucosa of urinary bladder

[Term]
id: UBERON:0004647
name: liver lobule
def: "the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" []
synonym: "hepatic lobule" EXACT []
synonym: "lobules of liver" RELATED []
synonym: "lobuli hepatici" EXACT []
synonym: "lobuli hepatis" RELATED []
synonym: "lobulus hepaticus" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: part_of UBERON:0001280 ! liver parenchyma

[Term]
id: UBERON:0004663
name: aorta wall
def: "An anatomical wall that is part of an aorta, enclosing the luminal space." []
synonym: "Aortic wall" EXACT []
synonym: "wall of aorta" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0004664
name: aorta tunica adventitia
def: "the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" []
synonym: "tunica adventitia of aorta" EXACT []
is_a: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0004663 ! aorta wall

[Term]
id: UBERON:0004665
name: muscular coat of seminal vesicle
def: "A muscular coat that is part of a seminal vesicle [Automatically generated definition]." []
synonym: "muscle layer of seminal vesicle" EXACT []
synonym: "muscular coat of seminal gland" EXACT []
synonym: "muscular layer of seminal gland" EXACT []
synonym: "tunica muscularis (Vesicula seminalis)" EXACT []
synonym: "tunica muscularis glandulae vesiculosae" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle

[Term]
id: UBERON:0004666
name: interventricular septum membranous part
def: "The membranous portion of the wall between the two lower chambers of the heart" []
synonym: "cardiac ventricular membranous septum" EXACT []
synonym: "membranous interventricular septum" EXACT []
synonym: "membranous interventricular septum" RELATED []
synonym: "membranous part interventricular septum" EXACT []
synonym: "membranous part of interventricular septum" EXACT []
synonym: "membranous portion of interventricular septum" EXACT []
synonym: "membranous septum" BROAD []
synonym: "pars membranacea (septi interventricularis)" EXACT []
synonym: "pars membranacea septi interventricularis" EXACT []
synonym: "ventricle membranous septum" BROAD []
synonym: "ventricular membranous septum" BROAD []
is_a: UBERON:0000158 ! membranous layer
is_a: UBERON:0005983 ! heart layer
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0000158 ! membranous layer
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: develops_from UBERON:0000095 ! cardiac neural crest
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: UBERON:0004667
name: interventricular septum muscular part
def: "The muscular portion of the wall between the two lower chambers of the heart" []
synonym: "cardiac ventricular muscular septum" EXACT []
synonym: "muscular interventricular septum" EXACT []
synonym: "muscular interventricular septum" RELATED []
synonym: "muscular part interventricular septum" EXACT []
synonym: "muscular part of interventricular septum" EXACT []
synonym: "muscular septum" BROAD []
synonym: "pars muscularis (septi interventricularis)" EXACT []
synonym: "pars muscularis septi interventricularis" EXACT []
synonym: "septum membranaceum" EXACT []
synonym: "ventricular muscular septum" EXACT []
is_a: UBERON:0002385 ! muscle tissue
intersection_of: UBERON:0002385 ! muscle tissue
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: UBERON:0004668
name: fourth ventricle aperture
def: "One of: the 4th ventricle median or lateral apertures." []
synonym: "aperture of 4th ventricle" EXACT []
synonym: "aperture of fourth ventricle" EXACT []
is_a: UBERON:0000161 ! orifice
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0002422 ! fourth ventricle
relationship: part_of UBERON:0002422 ! fourth ventricle

[Term]
id: UBERON:0004681
name: vestibular system
def: "The sensory system for the sense of balance." []
synonym: "equilibrioception system" NARROW []
synonym: "vestibular organ system" EXACT []
synonym: "vestibular system" EXACT []
synonym: "vestibulomotor system" NARROW []
is_a: UBERON:0001032 ! sensory system
relationship: part_of UBERON:0002105 ! vestibulo-auditory system

[Term]
id: UBERON:0004684
name: raphe nuclei
def: "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." []
synonym: "nuclei raphes" EXACT []
synonym: "nuclei raphes" RELATED []
synonym: "raphe cluster" RELATED []
synonym: "raphe nuclei" EXACT []
synonym: "raphe nuclei set" EXACT []
synonym: "raphe nucleus" RELATED []
synonym: "Raphe of mesenchephalon" RELATED []
synonym: "set of raphe nuclei" RELATED []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002275 ! reticular formation

[Term]
id: UBERON:0004693
name: Peyer's patch epithelium
def: "the specialized epithelium of the Peyer's patch" []
synonym: "peyer's patch epithelium" EXACT []
is_a: UBERON:0001277 ! intestinal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: part_of UBERON:0001211 ! Peyer's patch

[Term]
id: UBERON:0004695
name: arterial system smooth muscle
def: "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0004572 ! arterial system
relationship: part_of UBERON:0004572 ! arterial system

[Term]
id: UBERON:0004696
name: venous system smooth muscle
def: "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." []
is_a: UBERON:0004237 ! blood vessel smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0004582 ! venous system
relationship: part_of UBERON:0004237 ! blood vessel smooth muscle
relationship: part_of UBERON:0004582 ! venous system

[Term]
id: UBERON:0004697
name: Peyer's patch germinal center
def: "Area of the Peyer's patch where B cells proliferate and differentiate into plasma cells" []
is_a: UBERON:0010754 ! germinal center
intersection_of: UBERON:0010754 ! germinal center
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: part_of UBERON:0001211 ! Peyer's patch

[Term]
id: UBERON:0004699
name: outflow tract endothelium
def: "An endothelium that is part of a outflow tract [Automatically generated definition]." []
is_a: UBERON:0008307 ! heart endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0004145 ! outflow tract
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0004700
name: arterial system endothelium
def: "An endothelium that is part of an arterial system [Automatically generated definition]." []
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0004572 ! arterial system
relationship: part_of UBERON:0004572 ! arterial system

[Term]
id: UBERON:0004701
name: venous system endothelium
def: "An endothelium that is part of a venous system [Automatically generated definition]." []
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0004582 ! venous system
relationship: part_of UBERON:0004582 ! venous system

[Term]
id: UBERON:0004702
name: respiratory system blood vessel endothelium
def: "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004807 ! respiratory system epithelium
intersection_of: UBERON:0004638 ! blood vessel endothelium
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003504 ! respiratory system blood vessel

[Term]
id: UBERON:0004706
name: bulbus cordis
def: "a transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches" []
synonym: "primitive right ventricle endocardium" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0004708
name: paired limb/fin
def: "An appendage that is part of a appendage girdle complex." []
synonym: "girdle-associated appendage" EXACT []
synonym: "jointed paired lateral appendage" NARROW []
synonym: "limb or fin" EXACT []
synonym: "limb/fin" EXACT []
synonym: "paired appendage" NARROW []
synonym: "pectoral or pelvic appendage" EXACT []
synonym: "pelvic/pectoral appendage" EXACT []
is_a: UBERON:0000026 ! appendage
intersection_of: UBERON:0000026 ! appendage
intersection_of: part_of UBERON:0010707 ! appendage girdle complex
relationship: develops_from UBERON:0004357 ! paired limb/fin bud
relationship: has_part UBERON:0000014 ! zone of skin
relationship: has_part UBERON:0001015 ! musculature
relationship: has_part UBERON:0002049 ! vasculature
relationship: part_of UBERON:0010707 ! appendage girdle complex

[Term]
id: UBERON:0004709
name: pelvic appendage
def: "Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues." []
synonym: "hindlimb/pelvic fin" EXACT []
synonym: "pelvic appendage" EXACT []
synonym: "pelvic limb/fin" EXACT []
synonym: "posterior appendage" BROAD []
synonym: "posterior limb/fin" EXACT []
synonym: "posterior paired appendage" EXACT []
is_a: UBERON:0004708 ! paired limb/fin
intersection_of: UBERON:0004708 ! paired limb/fin
intersection_of: part_of UBERON:0010709 ! pelvic complex
disjoint_from: UBERON:0004710 ! pectoral appendage
relationship: develops_from UBERON:0005420 ! pelvic appendage bud
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0004710
name: pectoral appendage
def: "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." []
synonym: "anterior appendage" BROAD []
synonym: "anterior limb/fin" EXACT []
synonym: "anterior paired appendage" EXACT []
synonym: "forelimb - pectoral fin" EXACT []
synonym: "forelimb or pectoral fin" EXACT []
synonym: "forelimb/pectoral fin" EXACT []
synonym: "pectoral limb/fin" EXACT []
is_a: UBERON:0004708 ! paired limb/fin
intersection_of: UBERON:0004708 ! paired limb/fin
intersection_of: part_of UBERON:0010708 ! pectoral complex
relationship: develops_from UBERON:0005419 ! pectoral appendage bud
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0004715
name: annulus fibrosus disci intervertebralis
def: "The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." []
synonym: "annulus fibrosus" BROAD []
synonym: "annulus fibrosus of intervertebral disc" RELATED []
synonym: "anulus fibrosus (diskus intervertebralis)" EXACT []
synonym: "anulus fibrosus of intervertebral disk" EXACT []
synonym: "fibrous ring of intervertebral disc" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006444 ! annulus fibrosus
intersection_of: UBERON:0006444 ! annulus fibrosus
intersection_of: part_of UBERON:0001066 ! intervertebral disk
disjoint_from: UBERON:0006008 ! fibrous ring of heart
relationship: part_of UBERON:0001066 ! intervertebral disk

[Term]
id: UBERON:0004716
name: conceptus
def: "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." []
synonym: "embryo plus adnexa" EXACT []
is_a: UBERON:0000061 ! anatomical structure
relationship: has_part UBERON:0002050 ! embryonic structure
relationship: has_part UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0004719
name: kidney arcuate vein
def: "Any of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins." []
synonym: "arciform vein of kidney" EXACT []
synonym: "arcuate vein" BROAD []
synonym: "arcuate vein of kidney" EXACT []
synonym: "arcuate veins" RELATED []
synonym: "renal arcuate vein" EXACT []
synonym: "venae arcuatae renis" EXACT []
is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel

[Term]
id: UBERON:0004721
name: crista ampullaris
def: "The crista ampullaris is the sensory organ of rotation located in the semicircular canal of the inner ear. The function of the crista ampullaris is to sense angular acceleration and deceleration." []
synonym: "ampullary crest" RELATED []
synonym: "ampullary crest of semicircular duct" EXACT []
synonym: "cristae ampullares" RELATED []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0004043 ! semicircular canal ampulla

[Term]
id: UBERON:0004723
name: interlobular artery
def: "The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." []
synonym: "arteriae corticales radiatae" RELATED []
synonym: "arteriae interlobulares renis" RELATED []
synonym: "cortical radial arteries" RELATED []
synonym: "interlobular" RELATED []
synonym: "interlobular renal artery" EXACT []
synonym: "kidney interlobular artery" EXACT []
synonym: "renal interlobular artery" RELATED []
is_a: UBERON:0003644 ! kidney arterial blood vessel

[Term]
id: UBERON:0004726
name: vasa recta
def: "In the blood supply of the kidney, the vasa recta renis (or straight arteries of kidney, or straight arterioles of kidney) form a series of straight capillaries in the medulla. They lie parallel to the loop of Henle. These vessels branch off the efferent arterioles of juxtamedullary nephrons (those nephrons closest to the medulla), enter the medulla, and surround the loop of Henle." []
synonym: "arteria recta" RELATED []
synonym: "arteriae rectae" RELATED []
synonym: "arteriolae rectae renis" EXACT []
synonym: "arteriolae rectae renis" RELATED []
synonym: "arteriolae recti" RELATED []
synonym: "kidney vasa recta" EXACT []
synonym: "renal medullary capillary" EXACT []
synonym: "set of straight arterioles of kidney" EXACT []
synonym: "straight arterioles of kidney" EXACT []
synonym: "vasa recta of kidney" EXACT []
synonym: "vasa recta renis" EXACT []
synonym: "vasa rectae" RELATED []
is_a: UBERON:0001140 ! renal vein

[Term]
id: UBERON:0004731
name: neuromere
def: "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." []
synonym: "neural metamere" RELATED []
synonym: "neural segment" RELATED []
synonym: "neural tube metameric segment" EXACT []
synonym: "neural tube segment" EXACT []
synonym: "neuromere" EXACT []
synonym: "neuromeres" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004732 ! segmental subdivision of nervous system
intersection_of: UBERON:0004732 ! segmental subdivision of nervous system
intersection_of: part_of UBERON:0001049 ! neural tube
relationship: part_of UBERON:0001049 ! neural tube

[Term]
id: UBERON:0004732
name: segmental subdivision of nervous system
def: "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." []
synonym: "neuromere" RELATED []
is_a: UBERON:0000063 ! organ subunit
intersection_of: UBERON:0000063 ! organ subunit
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0004733
name: segmental subdivision of hindbrain
def: "An organ subunit that is part of a hindbrain [Automatically generated definition]." []
synonym: "hindbrain segment" EXACT []
synonym: "segment of hindbrain" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004732 ! segmental subdivision of nervous system
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000063 ! organ subunit
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0004734
name: gastrula
def: "Organism at the gastrula stage." []
synonym: "blastocystis trilaminaris" RELATED []
synonym: "gastrula embryo" EXACT []
synonym: "tri-laminar disc" RELATED []
synonym: "tri-laminar disk" RELATED []
synonym: "trilaminar blastocyst" RELATED []
synonym: "trilaminar blastoderm" RELATED []
synonym: "trilaminar disc" RELATED []
synonym: "trilaminar disk" RELATED []
synonym: "trilaminar germ" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000922 ! embryo
relationship: develops_from UBERON:0000307 ! blastula

[Term]
id: UBERON:0004736
name: metanephric glomerulus
def: "glomerulus of the mature vertebrate kidney, or metanephros." []
synonym: "glomerulus of metanephros" EXACT []
is_a: UBERON:0000074 ! renal glomerulus
intersection_of: UBERON:0000074 ! renal glomerulus
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0004737
name: metanephric collecting duct
def: "A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition]." []
synonym: "collecting duct of metanephros" EXACT []
synonym: "metanephric collecting tubule" RELATED []
is_a: UBERON:0001232 ! collecting duct of renal tubule
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: develops_from UBERON:0014706 ! primitive renal collecting duct system
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0004738
name: metanephric juxtaglomerular apparatus
def: "juxtaglomerular apparatus of the mature vertebrate kidney, or metanephros." []
synonym: "juxtaglomerular apparatus of metanephros" EXACT []
is_a: UBERON:0002303 ! juxtaglomerular apparatus
intersection_of: UBERON:0002303 ! juxtaglomerular apparatus
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0004739
name: pronephric glomerulus
def: "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." []
synonym: "corpuscle" RELATED []
synonym: "glomera" RELATED []
synonym: "glomerulus of pronephros" EXACT []
synonym: "glomus" NARROW []
synonym: "pronephric glomera" RELATED []
synonym: "pronephric glomeruli" RELATED []
synonym: "pronephric glomus" RELATED []
is_a: UBERON:0000074 ! renal glomerulus
intersection_of: UBERON:0000074 ! renal glomerulus
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: develops_from UBERON:0007128 ! glomeral mesenchyme
relationship: part_of UBERON:0002120 ! pronephros

[Term]
id: UBERON:0004755
name: skeletal tissue
def: "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]" []
is_a: UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0004765 ! skeletal element

[Term]
id: UBERON:0004756
name: dermal skeletal element
def: "dermis-derived entity that is made of skeletal tissue." []
synonym: "dermal element" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004765 ! skeletal element
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0004765 ! skeletal element
intersection_of: develops_from UBERON:0002067 ! dermis
intersection_of: has_part UBERON:0004755 ! skeletal tissue
relationship: develops_from UBERON:0002067 ! dermis
relationship: has_part UBERON:0004755 ! skeletal tissue

[Term]
id: UBERON:0004760
name: gland of anal canal
def: "A gland that is part of an anal canal [Automatically generated definition]." []
synonym: "anal gland" RELATED []
synonym: "anal sac" RELATED []
synonym: "gland of anal canal" EXACT []
synonym: "gland of anus" RELATED []
synonym: "rectal gland" RELATED []
is_a: UBERON:0003408 ! gland of gut
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0004761
name: cartilaginous neurocranium
def: "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." []
synonym: "cartilaginous chondocranium" EXACT []
synonym: "cartilaginous skull" RELATED []
synonym: "cartiligionous skeletal structure of skull" EXACT []
synonym: "chondocranium" RELATED []
synonym: "embryonic chondocranium" RELATED []
synonym: "neurocranium" RELATED []
is_a: UBERON:0000075 ! subdivision of skeletal system
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0009617 ! head paraxial mesoderm
relationship: has_part UBERON:0002418 ! cartilage tissue

[Term]
id: UBERON:0004765
name: skeletal element
def: "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." []
is_a: UBERON:0000062 ! organ
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0004766
name: cranial bone
def: "A bone that is part of a cranium." []
synonym: "cranium bone" EXACT []
is_a: UBERON:0003457 ! head bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0003128 ! cranium
relationship: part_of UBERON:0003128 ! cranium

[Term]
id: UBERON:0004768
name: bone of lower jaw
def: "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular" []
synonym: "lower jaw bone" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0012360 ! bone of jaw
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0001710 ! lower jaw region
relationship: part_of UBERON:0003278 ! skeleton of lower jaw

[Term]
id: UBERON:0004769
name: diaphysis
def: "Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified]." []
synonym: "body of long bone" EXACT []
synonym: "long bone diaphysis" EXACT []
synonym: "shaft of long bone" EXACT []
is_a: UBERON:0005055 ! zone of long bone

[Term]
id: UBERON:0004770
name: articular system
def: "Anatomical system that consists of all the joints of the body." []
synonym: "joint system" EXACT []
synonym: "set of all joints" RELATED []
synonym: "set of all joints of body" EXACT []
synonym: "set of joints of body" RELATED []
is_a: UBERON:0034925 ! anatomical collection
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0004775
name: outer renal medulla vasa recta
def: "A vasa recta that is part of a outer medulla of kidney [Automatically generated definition]." []
synonym: "kidney outer medulla vasa recta" EXACT []
synonym: "kidney outer renal medulla vasa recta" EXACT []
synonym: "outer medulla of kidney vasa recta" EXACT []
synonym: "outer zone of medulla of kidney vasa recta" EXACT []
synonym: "outer zone of renal medulla vasa recta" EXACT []
synonym: "vasa recta of outer medulla of kidney" EXACT []
synonym: "vasa recta of outer renal medulla" EXACT []
synonym: "vasa recta of outer zone of medulla of kidney" EXACT []
synonym: "vasa recta of outer zone of renal medulla" EXACT []
is_a: UBERON:0004726 ! vasa recta
is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel
intersection_of: UBERON:0004726 ! vasa recta
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0004776
name: inner renal medulla vasa recta
def: "A vasa recta that is part of a inner medulla of kidney [Automatically generated definition]." []
synonym: "inner medulla of kidney vasa recta" EXACT []
synonym: "inner zone of medulla of kidney vasa recta" EXACT []
synonym: "inner zone of renal medulla vasa recta" EXACT []
synonym: "set of inner region of renal pyramids vasa recta" EXACT []
synonym: "vasa recta of inner medulla of kidney" EXACT []
synonym: "vasa recta of inner renal medulla" EXACT []
synonym: "vasa recta of inner zone of medulla of kidney" EXACT []
synonym: "vasa recta of inner zone of renal medulla" EXACT []
synonym: "vasa recta of set of inner region of renal pyramids" EXACT []
is_a: UBERON:0004726 ! vasa recta
is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel
intersection_of: UBERON:0004726 ! vasa recta
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney

[Term]
id: UBERON:0004777
name: respiratory system submucosa
def: "A submucosa that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius submucosa" EXACT []
synonym: "submucosa of apparatus respiratorius" EXACT []
synonym: "submucosa of respiratory system" EXACT []
is_a: UBERON:0000009 ! submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003570 ! respiratory system connective tissue

[Term]
id: UBERON:0004779
name: respiratory system lamina propria
def: "A lamina propria that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius lamina propria" EXACT []
synonym: "apparatus respiratorius lamina propria mucosa" EXACT []
synonym: "lamina propria mucosa of apparatus respiratorius" EXACT []
synonym: "lamina propria mucosa of respiratory system" EXACT []
synonym: "lamina propria of apparatus respiratorius" EXACT []
synonym: "lamina propria of respiratory system" EXACT []
synonym: "respiratory system lamina propria mucosa" EXACT []
is_a: UBERON:0000030 ! lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003570 ! respiratory system connective tissue
relationship: part_of UBERON:0004785 ! respiratory system mucosa

[Term]
id: UBERON:0004780
name: gastrointestinal system lamina propria
def: "A lamina propria that is part of a gastrointestinal system." []
is_a: UBERON:0000030 ! lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004781
name: gall bladder lamina propria
def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." []
synonym: "biliary lamina propria" RELATED []
synonym: "gall bladder lamina propria mucosa" EXACT []
synonym: "gallbladder lamina propria" EXACT []
synonym: "gallbladder lamina propria mucosa" EXACT []
synonym: "lamina propria mucosa of gall bladder" EXACT []
synonym: "lamina propria mucosa of gallbladder" EXACT []
synonym: "lamina propria of gall bladder" EXACT []
synonym: "lamina propria of gallbladder" EXACT []
is_a: UBERON:0000030 ! lamina propria
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0005033 ! mucosa of gallbladder

[Term]
id: UBERON:0004782
name: gastrointestinal system serosa
def: "A serous membrane that is part of a digestive system [Automatically generated definition]." []
synonym: "digestive system serosa" EXACT []
synonym: "digestive system serous membrane" EXACT []
synonym: "gastrointestinal system serous membrane" EXACT []
synonym: "serosa of digestive system" EXACT []
synonym: "serosa of gastrointestinal system" EXACT []
synonym: "serous membrane of digestive system" EXACT []
synonym: "serous membrane of gastrointestinal system" EXACT []
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004783
name: gall bladder serosa
def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." []
synonym: "biliary serosa" RELATED []
synonym: "gall bladder serous membrane" EXACT []
synonym: "gallbladder serosa" EXACT []
synonym: "gallbladder serous membrane" EXACT []
synonym: "serosa of gall bladder" EXACT []
synonym: "serosa of gallbladder" EXACT []
synonym: "serous coat of gallbladder" EXACT []
synonym: "serous membrane of gall bladder" EXACT []
synonym: "serous membrane of gallbladder" EXACT []
synonym: "tunica serosa (vesica biliaris)" EXACT []
synonym: "tunica serosa vesicae biliaris" EXACT []
is_a: UBERON:0000042 ! serous membrane
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: UBERON:0004784
name: heart ventricle wall
def: "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." []
synonym: "anatomical wall of cardiac ventricle" EXACT []
synonym: "anatomical wall of heart ventricle" EXACT []
synonym: "anatomical wall of lower chamber of heart" EXACT []
synonym: "anatomical wall of ventricle of heart" EXACT []
synonym: "cardiac ventricle anatomical wall" EXACT []
synonym: "cardiac ventricle wall" EXACT []
synonym: "heart ventricle anatomical wall" EXACT []
synonym: "lower chamber of heart anatomical wall" EXACT []
synonym: "lower chamber of heart wall" EXACT []
synonym: "ventricle of heart anatomical wall" EXACT []
synonym: "ventricle of heart wall" EXACT []
synonym: "ventricular wall" EXACT []
synonym: "wall of cardiac ventricle" EXACT []
synonym: "wall of heart ventricle" EXACT []
synonym: "wall of lower chamber of heart" EXACT []
synonym: "wall of ventricle" RELATED []
synonym: "wall of ventricle of heart" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle

[Term]
id: UBERON:0004785
name: respiratory system mucosa
def: "the mucous membrane lining the respiratory tract" []
synonym: "apparatus respiratorius mucosa" EXACT []
synonym: "apparatus respiratorius mucosa of organ" EXACT []
synonym: "apparatus respiratorius mucous membrane" EXACT []
synonym: "laryngeal mucous membrane" RELATED []
synonym: "mucosa of apparatus respiratorius" EXACT []
synonym: "mucosa of organ of apparatus respiratorius" EXACT []
synonym: "mucosa of organ of respiratory system" EXACT []
synonym: "mucosa of respiratory system" EXACT []
synonym: "mucous membrane of apparatus respiratorius" EXACT []
synonym: "mucous membrane of respiratory system" EXACT []
synonym: "respiratory mucosa" RELATED []
synonym: "respiratory system mucosa of organ" EXACT []
synonym: "respiratory system mucous membrane" EXACT []
synonym: "respiratory tract mucosa" RELATED []
is_a: UBERON:0000344 ! mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0004786
name: gastrointestinal system mucosa
def: "A mucosa that is part of a gastrointestinal system." []
synonym: "digestive tract mucosa" EXACT []
synonym: "gut mucosa" EXACT []
synonym: "gut mucuous membrane" EXACT []
synonym: "mucosa of gut" EXACT []
is_a: UBERON:0000344 ! mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004787
name: urethra urothelium
def: "An urothelium that is part of a urethra [Automatically generated definition]." []
synonym: "urethra Uroepithelium" EXACT []
synonym: "uroepithelium of urethra" EXACT []
synonym: "urothelium of urethra" EXACT []
is_a: UBERON:0000365 ! urothelium
is_a: UBERON:0002325 ! epithelium of urethra
intersection_of: UBERON:0000365 ! urothelium
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0004788
name: kidney pelvis urothelium
def: "the epithelial lining of the luminal space of the kidney pelvis" []
synonym: "kidney pelvis transitional epithelium" EXACT []
synonym: "kidney pelvis Uroepithelium" EXACT []
synonym: "pelvic urothelium" RELATED []
synonym: "pelvis of ureter Uroepithelium" EXACT []
synonym: "pelvis of ureter urothelium" EXACT []
synonym: "renal pelvis transitional epithelium" EXACT []
synonym: "renal pelvis Uroepithelium" EXACT []
synonym: "renal pelvis urothelium" EXACT []
synonym: "transitional epithelium of kidney pelvis" EXACT []
synonym: "transitional epithelium of renal pelvis" EXACT []
synonym: "uroepithelium of kidney pelvis" EXACT []
synonym: "uroepithelium of pelvis of ureter" EXACT []
synonym: "uroepithelium of renal pelvis" EXACT []
synonym: "urothelium of kidney pelvis" EXACT []
synonym: "urothelium of pelvis of ureter" EXACT []
synonym: "urothelium of renal pelvis" EXACT []
is_a: UBERON:0001254 ! urothelium of ureter
is_a: UBERON:0004819 ! kidney epithelium
intersection_of: UBERON:0000365 ! urothelium
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis

[Term]
id: UBERON:0004790
name: skin mucous gland
def: "A mucous gland that is part of the skin." []
synonym: "mucous gland of entire skin" EXACT []
synonym: "mucous gland of skin of body" EXACT []
synonym: "skin mucus gland" EXACT []
synonym: "skin of body mucous gland" EXACT []
is_a: UBERON:0000414 ! mucous gland
is_a: UBERON:0007771 ! epidermis gland
is_a: UBERON:0019319 ! exocrine gland of integumental system
intersection_of: UBERON:0000414 ! mucous gland
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0002097 ! skin of body

[Term]
id: UBERON:0004797
name: blood vessel layer
def: "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0004801
name: cervix epithelium
def: "An epithelium that is part of a uterine cervix [Automatically generated definition]." []
synonym: "cervical canal epithelial tissue" EXACT []
synonym: "cervical canal epithelium" EXACT []
synonym: "cervical epithelium" EXACT []
synonym: "cervix epithelial tissue" EXACT []
synonym: "epithelium of cervix" EXACT []
is_a: UBERON:0006955 ! uterine epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix

[Term]
id: UBERON:0004802
name: respiratory tract epithelium
def: "the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" []
synonym: "airway epithelium" RELATED []
synonym: "epithelial tissue of respiratory tract" EXACT []
synonym: "epithelium of respiratory tract" EXACT []
synonym: "respiratory epithelium" RELATED []
synonym: "respiratory tract epithelial tissue" EXACT []
is_a: UBERON:0004807 ! respiratory system epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000072 ! proximo-distal subdivision of respiratory tract

[Term]
id: UBERON:0004803
name: penis epithelium
def: "An epithelium that is part of a penis [Automatically generated definition]." []
synonym: "epithelial tissue of penis" EXACT []
synonym: "epithelium of penis" EXACT []
synonym: "penis epithelial tissue" EXACT []
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000989 ! penis
relationship: part_of UBERON:0000989 ! penis

[Term]
id: UBERON:0004804
name: oviduct epithelium
def: "An epithelium that is part of a oviduct [Automatically generated definition]." []
synonym: "columnar epithelium of the Fallopian tube" RELATED []
synonym: "columnar epithelium of the oviduct" RELATED []
synonym: "epithelial tissue of oviduct" EXACT []
synonym: "epithelium of fallopian tube" EXACT []
synonym: "epithelium of oviduct" EXACT []
synonym: "epithelium of uterine tube" EXACT []
synonym: "fallopian tube epithelium" RELATED []
synonym: "oviduct epithelial tissue" EXACT []
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0004805
name: seminal vesicle epithelium
def: "An epithelium that is part of a seminal vesicle [Automatically generated definition]." []
synonym: "epithelial tissue of seminal gland" EXACT []
synonym: "epithelial tissue of seminal vesicle" EXACT []
synonym: "epithelium of seminal gland" EXACT []
synonym: "epithelium of seminal vesicle" EXACT []
synonym: "seminal gland epithelial tissue" EXACT []
synonym: "seminal gland epithelium" EXACT []
synonym: "seminal vesicle epithelial tissue" EXACT []
is_a: UBERON:0004910 ! epithelium of male gonad
is_a: UBERON:0012275 ! meso-epithelium
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle

[Term]
id: UBERON:0004807
name: respiratory system epithelium
def: "An epithelium that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius epithelial tissue" EXACT []
synonym: "apparatus respiratorius epithelium" EXACT []
synonym: "epithelial tissue of apparatus respiratorius" EXACT []
synonym: "epithelial tissue of respiratory system" EXACT []
synonym: "epithelium of apparatus respiratorius" EXACT []
synonym: "epithelium of respiratory system" EXACT []
synonym: "respiratory system epithelial tissue" EXACT []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0004808
name: gastrointestinal system epithelium
def: "An epithelium that is part of a digestive system [Automatically generated definition]." []
synonym: "digestive system epithelial tissue" EXACT []
synonym: "digestive system epithelium" EXACT []
synonym: "epithelial tissue of digestive system" EXACT []
synonym: "epithelial tissue of gastrointestinal system" EXACT []
synonym: "epithelium of digestive system" EXACT []
synonym: "epithelium of gastrointestinal system" EXACT []
synonym: "gastrointestinal system epithelial tissue" EXACT []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004809
name: salivary gland epithelium
def: "An epithelium that is part of a salivary gland [Automatically generated definition]." []
synonym: "epithelial tissue of salivary gland" EXACT []
synonym: "epithelium of salivary gland" EXACT []
synonym: "salivary gland epithelial tissue" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland

[Term]
id: UBERON:0004810
name: nephron tubule epithelium
def: "the cellular avascular layer of the renal tubule luminar surfaces" []
synonym: "epithelial tissue of nephron tubule" EXACT []
synonym: "epithelial tissue of renal tubule" EXACT []
synonym: "epithelial tissue of tubulus renalis" EXACT []
synonym: "epithelium of nephron tubule" EXACT []
synonym: "epithelium of renal tubule" EXACT []
synonym: "epithelium of tubulus renalis" EXACT []
synonym: "kidney tubule epithelium" EXACT []
synonym: "nephron tubule epithelial tissue" EXACT []
synonym: "nephron tubule epithelium" EXACT []
synonym: "renal tubule epithelial tissue" EXACT []
synonym: "tubulus renalis epithelial tissue" EXACT []
synonym: "tubulus renalis epithelium" EXACT []
is_a: UBERON:0004211 ! nephron epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule

[Term]
id: UBERON:0004811
name: endometrium epithelium
def: "An epithelium that is part of an endometrium [Automatically generated definition]." []
synonym: "endometrium epithelial tissue" EXACT []
synonym: "epithelial tissue of endometrium" EXACT []
synonym: "epithelium of endometrium" EXACT []
synonym: "epithelium of tunica mucosa of endometrium" EXACT []
synonym: "uterine epithelium" RELATED []
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0006955 ! uterine epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium

[Term]
id: UBERON:0004812
name: male prepuce epithelium
def: "An epithelium that is part of a prepuce of penis [Automatically generated definition]." []
synonym: "epithelial tissue of foreskin" EXACT []
synonym: "epithelial tissue of penile prepuce" EXACT []
synonym: "epithelial tissue of prepuce" BROAD []
synonym: "epithelial tissue of prepuce of penis" EXACT []
synonym: "epithelium of foreskin" EXACT []
synonym: "epithelium of penile prepuce" EXACT []
synonym: "epithelium of prepuce" BROAD []
synonym: "epithelium of prepuce of penis" EXACT []
synonym: "foreskin epithelial tissue" EXACT []
synonym: "foreskin epithelium" EXACT []
synonym: "penile prepuce epithelial tissue" EXACT []
synonym: "penile prepuce epithelium" EXACT []
synonym: "prepuce epithelial tissue" BROAD []
synonym: "prepuce epithelium" EXACT []
synonym: "prepuce of penis epithelial tissue" EXACT []
synonym: "prepuce of penis epithelium" BROAD []
is_a: UBERON:0004803 ! penis epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis

[Term]
id: UBERON:0004813
name: seminiferous tubule epithelium
def: "the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" []
synonym: "epithelial tissue of seminiferous tubule" EXACT []
synonym: "epithelial tissue of seminiferous tubule of testis" EXACT []
synonym: "epithelium of seminiferous tubule" EXACT []
synonym: "epithelium of seminiferous tubule of testis" EXACT []
synonym: "germinal epithelium (male)" EXACT []
synonym: "male germinal epithelium" EXACT []
synonym: "seminiferous epithelium" EXACT []
synonym: "seminiferous tubule epithelial tissue" EXACT []
synonym: "testis germinal epithelium" EXACT []
synonym: "wall of seminiferous tubule" EXACT []
is_a: UBERON:0001136 ! mesothelium
is_a: UBERON:0004910 ! epithelium of male gonad
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis

[Term]
id: UBERON:0004814
name: upper respiratory tract epithelium
def: "An epithelium that is part of a upper respiratory tract [Automatically generated definition]." []
synonym: "epithelial tissue of upper respiratory tract" EXACT []
synonym: "epithelium of upper respiratory tract" EXACT []
synonym: "upper respiratory tract epithelial tissue" EXACT []
is_a: UBERON:0004802 ! respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001557 ! upper respiratory tract
relationship: part_of UBERON:0001557 ! upper respiratory tract

[Term]
id: UBERON:0004815
name: lower respiratory tract epithelium
def: "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." []
synonym: "epithelial tissue of lower respiratory tract" EXACT []
synonym: "epithelium of lower respiratory tract" EXACT []
synonym: "lower respiratory tract epithelial tissue" EXACT []
is_a: UBERON:0004802 ! respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0004817
name: lacrimal gland epithelium
def: "An epithelium that is part of a lacrimal gland [Automatically generated definition]." []
synonym: "epithelial tissue of lacrimal gland" EXACT []
synonym: "epithelium of lacrimal gland" EXACT []
synonym: "lacrimal gland epithelial tissue" EXACT []
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001817 ! lacrimal gland
relationship: part_of UBERON:0001817 ! lacrimal gland

[Term]
id: UBERON:0004819
name: kidney epithelium
def: "the cellular avascular layer of the kidney luminar surfaces" []
synonym: "epithelial tissue of kidney" EXACT []
synonym: "epithelium of kidney" EXACT []
synonym: "kidney epithelial tissue" EXACT []
synonym: "renal epithelium" RELATED []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0004820
name: bile duct epithelium
def: "Any epithelium that lines one of the bile ducts." []
synonym: "biliary duct epithelium" EXACT []
synonym: "epithelium of bile duct" EXACT []
synonym: "epithelium of biliary duct" EXACT []
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0034932 ! epithelium of biliary system
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002394 ! bile duct
relationship: part_of UBERON:0002394 ! bile duct

[Term]
id: UBERON:0004821
name: pulmonary alveolus epithelium
def: "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." []
synonym: "alveolar epithelium" RELATED []
synonym: "alveolus epithelial tissue" EXACT []
synonym: "alveolus epithelium" EXACT []
synonym: "epithelial tissue of alveolus" EXACT []
synonym: "epithelium of alveolus" EXACT []
synonym: "epithelium of pulmonary alveolus" EXACT []
synonym: "pulmonary alveolar epithelium" EXACT []
synonym: "pulmonary alveolus epithelium" EXACT []
is_a: UBERON:0000115 ! lung epithelium
is_a: UBERON:0000487 ! simple squamous epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0004894 ! alveolar wall

[Term]
id: UBERON:0004822
name: extrahepatic bile duct epithelium
def: "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." []
synonym: "epithelial tissue of extrahepatic bile duct" EXACT []
synonym: "epithelium of extrahepatic bile duct" EXACT []
synonym: "extrahepatic bile duct epithelial tissue" EXACT []
is_a: UBERON:0004820 ! bile duct epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003703 ! extrahepatic bile duct
relationship: part_of UBERON:0003703 ! extrahepatic bile duct

[Term]
id: UBERON:0004823
name: intrahepatic bile duct epithelium
def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." []
synonym: "epithelial tissue of intrahepatic bile duct" EXACT []
synonym: "epithelium of intrahepatic bile duct" EXACT []
synonym: "intrahepatic bile duct epithelial tissue" EXACT []
is_a: UBERON:0004820 ! bile duct epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003704 ! intrahepatic bile duct
relationship: part_of UBERON:0003704 ! intrahepatic bile duct

[Term]
id: UBERON:0004827
name: thyroid gland medulla
def: "A medulla that is part of a thyroid [Automatically generated definition]." []
synonym: "medulla of thyroid" EXACT []
synonym: "medulla of thyroid follicle" EXACT []
synonym: "medulla of thyroid gland" EXACT []
synonym: "medulla of thyroid gland follicle" EXACT []
synonym: "thyroid follicle medulla" EXACT []
synonym: "thyroid gland follicle medulla" EXACT []
synonym: "thyroid medulla" EXACT []
is_a: UBERON:0000958 ! medulla of organ
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0004829
name: urethra skeletal muscle tissue
def: "A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition]." []
synonym: "skeletal muscle of urethra" EXACT []
synonym: "skeletal muscle tissue of urethra" EXACT []
synonym: "urethra skeletal muscle" RELATED []
synonym: "urethra skeletal muscle tissue" EXACT []
synonym: "urethral skeletal muscle" RELATED []
is_a: UBERON:0001134 ! skeletal muscle tissue
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0003829 ! urethra muscle tissue

[Term]
id: UBERON:0004830
name: respiratory system skeletal muscle
def: "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." []
synonym: "respiratory system skeletal muscle tissue" EXACT []
synonym: "skeletal muscle of apparatus respiratorius" EXACT []
synonym: "skeletal muscle of respiratory system" EXACT []
synonym: "skeletal muscle tissue of apparatus respiratorius" EXACT []
synonym: "skeletal muscle tissue of respiratory system" EXACT []
is_a: UBERON:0001134 ! skeletal muscle tissue
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0004831
name: esophagus skeletal muscle
def: "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." []
synonym: "esophagus skeletal muscle tissue" EXACT []
synonym: "skeletal muscle of esophagus" EXACT []
is_a: UBERON:0003898 ! skeletal muscle tissue of trunk
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0003832 ! esophagus muscle

[Term]
id: UBERON:0004832
name: anal region skeletal muscle
def: "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." []
synonym: "anal part of perineum skeletal muscle" EXACT []
synonym: "anal part of perineum skeletal muscle tissue" EXACT []
synonym: "anal region skeletal muscle tissue" EXACT []
synonym: "anal triangle skeletal muscle" EXACT []
synonym: "anal triangle skeletal muscle tissue" EXACT []
synonym: "skeletal muscle of anal part of perineum" EXACT []
synonym: "skeletal muscle of anal region" EXACT []
synonym: "skeletal muscle of anal triangle" EXACT []
synonym: "skeletal muscle tissue of anal part of perineum" EXACT []
synonym: "skeletal muscle tissue of anal region" EXACT []
synonym: "skeletal muscle tissue of anal triangle" EXACT []
is_a: UBERON:0001134 ! skeletal muscle tissue
intersection_of: UBERON:0001134 ! skeletal muscle tissue
intersection_of: part_of UBERON:0001353 ! anal region
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0004834
name: hepatic duct smooth muscle
def: "Smooth muscle tissue in all or part of a hepatic duct." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0005171 ! hepatic duct
relationship: part_of UBERON:0005171 ! hepatic duct

[Term]
id: UBERON:0004835
name: epididymis smooth muscle
def: "A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition]." []
synonym: "epididymis involuntary muscle" EXACT []
synonym: "epididymis non-striated muscle" EXACT []
synonym: "epididymis smooth muscle tissue" EXACT []
synonym: "epididymus involuntary muscle" EXACT []
synonym: "epididymus non-striated muscle" EXACT []
synonym: "epididymus smooth muscle" EXACT []
synonym: "epididymus smooth muscle tissue" EXACT []
synonym: "involuntary muscle of epididymis" EXACT []
synonym: "involuntary muscle of epididymus" EXACT []
synonym: "non-striated muscle of epididymis" EXACT []
synonym: "non-striated muscle of epididymus" EXACT []
synonym: "smooth muscle of epididymis" EXACT []
synonym: "smooth muscle of epididymus" EXACT []
synonym: "smooth muscle tissue of epididymis" EXACT []
synonym: "smooth muscle tissue of epididymus" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis

[Term]
id: UBERON:0004848
name: respiratory system arterial endothelium
def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius arterial endothelium" EXACT []
synonym: "apparatus respiratorius artery endothelium" EXACT []
synonym: "apparatus respiratorius endothelium of artery" EXACT []
synonym: "arterial endothelium of apparatus respiratorius" EXACT []
synonym: "arterial endothelium of respiratory system" EXACT []
synonym: "artery endothelium of apparatus respiratorius" EXACT []
synonym: "artery endothelium of respiratory system" EXACT []
synonym: "endothelium of artery of apparatus respiratorius" EXACT []
synonym: "endothelium of artery of respiratory system" EXACT []
synonym: "respiratory system artery endothelium" EXACT []
synonym: "respiratory system endothelium of artery" EXACT []
is_a: UBERON:0001917 ! endothelium of artery
is_a: UBERON:0004702 ! respiratory system blood vessel endothelium
intersection_of: UBERON:0001917 ! endothelium of artery
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003469 ! respiratory system artery
relationship: part_of UBERON:0003504 ! respiratory system blood vessel
relationship: part_of UBERON:0003643 ! respiratory system arterial blood vessel

[Term]
id: UBERON:0004849
name: respiratory system venous endothelium
def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." []
synonym: "apparatus respiratorius endothelium of vein" EXACT []
synonym: "apparatus respiratorius vein endothelium" EXACT []
synonym: "apparatus respiratorius venous endothelium" EXACT []
synonym: "endothelium of vein of apparatus respiratorius" EXACT []
synonym: "endothelium of vein of respiratory system" EXACT []
synonym: "respiratory system endothelium of vein" EXACT []
synonym: "respiratory system vein endothelium" EXACT []
synonym: "vein endothelium of apparatus respiratorius" EXACT []
synonym: "vein endothelium of respiratory system" EXACT []
synonym: "venous endothelium of apparatus respiratorius" EXACT []
synonym: "venous endothelium of respiratory system" EXACT []
is_a: UBERON:0001919 ! endothelium of vein
is_a: UBERON:0004702 ! respiratory system blood vessel endothelium
intersection_of: UBERON:0001919 ! endothelium of vein
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel
relationship: part_of UBERON:0003504 ! respiratory system blood vessel

[Term]
id: UBERON:0004850
name: lymph node endothelium
def: "An endothelium that is part of a lymph node [Automatically generated definition]." []
synonym: "endothelium of lymph node" EXACT []
is_a: UBERON:0001986 ! endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: UBERON:0004851
name: aorta endothelium
def: "the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall" []
synonym: "adult aorta endothelium" EXACT []
synonym: "aortic endothelium" RELATED []
synonym: "endothelium of adult aorta" EXACT []
synonym: "endothelium of aorta" EXACT []
synonym: "endothelium of trunk of aortic tree" EXACT []
synonym: "endothelium of trunk of systemic arterial tree" EXACT []
synonym: "trunk of aortic tree endothelium" EXACT []
synonym: "trunk of systemic arterial tree endothelium" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0004700 ! arterial system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0004852
name: cardiovascular system endothelium
def: "An endothelium that is part of the cardiovascular system." []
synonym: "endothelia" RELATED []
synonym: "vascular endothelia" RELATED []
is_a: UBERON:0001986 ! endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0004535 ! cardiovascular system
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0004854
name: gastrointestinal system mesentery
def: "A mesentery that is part of a digestive system [Automatically generated definition]." []
synonym: "digestive system mesentery" EXACT []
synonym: "mesentery of digestive system" EXACT []
synonym: "mesentery of gastrointestinal system" EXACT []
is_a: UBERON:0002095 ! mesentery
is_a: UBERON:0004782 ! gastrointestinal system serosa
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004859
name: eye gland
def: "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." []
synonym: "eye-associated gland" EXACT []
synonym: "gland of eye" EXACT []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye

[Term]
id: UBERON:0004861
name: right lung alveolus
def: "An alveolus that is part of a right lung [Automatically generated definition]." []
synonym: "alveolus of right lung" EXACT []
is_a: UBERON:0002299 ! alveolus of lung
intersection_of: UBERON:0003215 ! alveolus
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0006526 ! right lung alveolar system

[Term]
id: UBERON:0004862
name: left lung alveolus
def: "An alveolus that is part of a left lung [Automatically generated definition]." []
synonym: "alveolus of left lung" EXACT []
synonym: "alveolus of lobe of left lung" EXACT []
is_a: UBERON:0002299 ! alveolus of lung
intersection_of: UBERON:0003215 ! alveolus
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0006525 ! left lung alveolar system

[Term]
id: UBERON:0004864
name: vasculature of retina
def: "A vasculature that is part of a retina [Automatically generated definition]." []
synonym: "retina vasculature" EXACT []
synonym: "retina vasculature of camera-type eye" EXACT []
synonym: "retinal blood vessels" EXACT []
synonym: "retinal blood vessels set" EXACT []
synonym: "retinal vasculature" EXACT []
synonym: "set of blood vessels of retina" EXACT []
synonym: "set of retinal blood vessels" EXACT []
synonym: "vasa sanguinea retinae" EXACT []
is_a: UBERON:0002203 ! vasculature of eye
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina

[Term]
id: UBERON:0004871
name: somatic layer of lateral plate mesoderm
def: "Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP]." []
synonym: "outer layer of lateral plate mesoderm" EXACT []
synonym: "parietal mesoderm" RELATED []
synonym: "somatic mesoderm" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0004872
name: splanchnic layer of lateral plate mesoderm
def: "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." []
synonym: "inner layer of lateral plate mesoderm" EXACT []
synonym: "splanchnic mesoderm" RELATED []
synonym: "visceral mesoderm" BROAD []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0004874
name: somatopleure
def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0004875
name: nephrogenic cord
def: "A portion of the urogenital ridge which is the source of much of the urinary system[WP]." []
synonym: "chorda nephrogenica" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004876 ! urogenital fold
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0004876
name: urogenital fold
def: "One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]." []
synonym: "urethral fold" EXACT []
synonym: "urogenital fold" EXACT []
synonym: "urogenital ridge" RELATED []
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: develops_from UBERON:0012292 ! embryonic cloacal fold
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0009196 ! indifferent external genitalia

[Term]
id: UBERON:0004877
name: visceral endoderm
def: "Visceral endoderm, a population of extraembyonic endoderm, is an extraembryonic tissue that functions in a regulatory capacity but does not contribute directly to the formation of any adult organs[PMID:15905405]. primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut[MP]." []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005292 ! extraembryonic tissue
relationship: develops_from UBERON:0000925 ! endoderm

[Term]
id: UBERON:0004880
name: chordamesoderm
def: "The central region of trunk mesoderm. This tissue forms the notochord" []
synonym: "axial chorda mesoderm" EXACT []
synonym: "chorda mesoderm" EXACT []
synonym: "dorsal mesoderm" EXACT []
synonym: "presumptive notochord" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0003068 ! axial mesoderm

[Term]
id: UBERON:0004883
name: lung mesenchyme
def: "The mass of tissue made up of mesenchymal cells in the lung." []
synonym: "lung-associated mesenchyme" EXACT []
synonym: "mesenchyme of lung" EXACT []
synonym: "pulmonary mesenchyme" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002048 ! lung
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0004894
name: alveolar wall
def: "A wall that contains the alveoli" []
synonym: "alveolus wall" RELATED []
synonym: "pulmonary alveolar wall" EXACT []
synonym: "pulmonary interalveolar septum" EXACT []
synonym: "wall of pulmonary alveolus" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0002299 ! alveolus of lung

[Term]
id: UBERON:0004895
name: alveolar smooth muscle
def: "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus" []
is_a: UBERON:0004233 ! lower respiratory tract smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0002299 ! alveolus of lung

[Term]
id: UBERON:0004902
name: urogenital sinus epithelium
def: "The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra" []
synonym: "epithelium of urogenital sinus" EXACT []
synonym: "UGE" EXACT []
is_a: UBERON:0009846 ! embryonic cloacal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000164 ! primitive urogenital sinus
relationship: develops_from UBERON:0009846 ! embryonic cloacal epithelium
relationship: part_of UBERON:0000164 ! primitive urogenital sinus

[Term]
id: UBERON:0004905
name: articulation
def: "Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts." []
synonym: "joint" NARROW []
is_a: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0004770 ! articular system

[Term]
id: UBERON:0004906
name: ectodermal part of digestive tract
def: "A portion of the gut that is derived from ectoderm." []
synonym: "ectodermal gut" EXACT []
synonym: "gut ectoderm" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004921 ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0004907
name: lower digestive tract
def: "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." []
synonym: "gut" BROAD []
synonym: "lower gastrointestinal tract" EXACT []
synonym: "lower GI tract" EXACT []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001046 ! hindgut
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0004908
name: upper digestive tract
def: "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." []
synonym: "upper gastrointestinal tract" EXACT []
synonym: "upper GI tract" EXACT []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001041 ! foregut

[Term]
id: UBERON:0004909
name: epithelium of gonad
def: "An epithelium surrounding a gonad." []
synonym: "gonad epithelium" EXACT []
synonym: "gonadal epithelium" EXACT []
synonym: "gonadal sheath" RELATED []
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000991 ! gonad
relationship: part_of UBERON:0000991 ! gonad

[Term]
id: UBERON:0004910
name: epithelium of male gonad
def: "An epithelium surrounding a testis." []
synonym: "testis epithelium" EXACT []
synonym: "testis sheath" NARROW []
is_a: UBERON:0004909 ! epithelium of gonad
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000473 ! testis
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0004911
name: epithelium of female gonad
def: "An epithelium surrounding an ovary." []
synonym: "ovarian epithelium" EXACT []
synonym: "ovarian sheath" NARROW []
synonym: "ovary epithelium" EXACT []
is_a: UBERON:0004909 ! epithelium of gonad
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0004912
name: biliary bud
synonym: "hepatic diverticulum" RELATED []
is_a: UBERON:0004185 ! endodermal part of digestive tract
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0004161 ! septum transversum
relationship: part_of UBERON:0002423 ! hepatobiliary system
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0004916
name: anal sphincter
def: "A sphincter muscle that is part of a anal region." []
synonym: "anal region sphincter" EXACT []
synonym: "sphincter analia" EXACT []
is_a: UBERON:0004590 ! sphincter muscle
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0001353 ! anal region
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0004917
name: urethral sphincter
def: "A sphincter muscle surrounding the urethra." []
synonym: "sphincter muscle of urethra" EXACT []
synonym: "sphincter of urethra" EXACT []
synonym: "sphincter urethrae" EXACT []
synonym: "urethral sphincter muscle" EXACT []
is_a: UBERON:0003829 ! urethra muscle tissue
is_a: UBERON:0004590 ! sphincter muscle
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: UBERON:0004921
name: subdivision of digestive tract
def: "A proximal-distal subdivision of the digestive tract." []
synonym: "alimentary system subdivision" RELATED []
synonym: "intestinal tract" RELATED []
synonym: "segment of intestinal tract" RELATED []
synonym: "subdivision of alimentary system" RELATED []
is_a: UBERON:0013522 ! subdivision of tube
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0004923
name: organ component layer
def: "A part of a wall of an organ that forms a layer." []
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0000060 ! anatomical wall

[Term]
id: UBERON:0004924
name: submucosa of pharynx
def: "The tissue underlying the tunica mucosa of the pharynx." []
synonym: "pharyngeal submucosa" EXACT []
synonym: "pharyngobasilar fascia" RELATED []
synonym: "pharynx submucosa" EXACT []
synonym: "submucous coat of pharynx" RELATED []
synonym: "submucous layer of pharynx" RELATED []
synonym: "tela submucosa pharyngea" EXACT []
synonym: "tela submucosa pharyngis" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004777 ! respiratory system submucosa
is_a: UBERON:0018257 ! submucosa of digestive tract
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0004926
name: submucosa of cystic duct
def: "A submucosa that is part of a cystic duct [Automatically generated definition]." []
synonym: "cystic duct submucosa" EXACT []
synonym: "cystic ductal submucosa" EXACT []
is_a: UBERON:0004938 ! submucosa of biliary tree
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001152 ! cystic duct
relationship: part_of UBERON:0001152 ! cystic duct

[Term]
id: UBERON:0004927
name: submucosa of cecum
def: "A submucosa that is part of a cecum [Automatically generated definition]." []
synonym: "caecum submucosa" EXACT []
synonym: "cecum submucosa" EXACT []
synonym: "intestinum crassum caecum submucosa" EXACT []
synonym: "submucosa of caecum" EXACT []
synonym: "submucosa of intestinum crassum caecum" EXACT []
is_a: UBERON:0003331 ! submucosa of colon
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0004928
name: submucosa of appendix
def: "A submucosa that is part of an appendix [Automatically generated definition]." []
synonym: "appendiceal submucosa" EXACT []
synonym: "appendix submucosa" EXACT []
synonym: "caecal appendix submucosa" EXACT []
synonym: "submucosa of caecal appendix" EXACT []
synonym: "submucosa of vermiform appendix" EXACT []
synonym: "submucosa of vermix" EXACT []
synonym: "vermiform appendix submucosa" EXACT []
synonym: "vermix submucosa" EXACT []
is_a: UBERON:0004927 ! submucosa of cecum
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: UBERON:0004929
name: submucosa of ascending colon
def: "A submucosa that is part of an ascending colon [Automatically generated definition]." []
synonym: "ascending colon submucosa" EXACT []
is_a: UBERON:0003331 ! submucosa of colon
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001156 ! ascending colon
relationship: part_of UBERON:0001156 ! ascending colon

[Term]
id: UBERON:0004930
name: submucosa of transverse colon
def: "A submucosa that is part of a transverse colon [Automatically generated definition]." []
synonym: "transverse colon submucosa" EXACT []
is_a: UBERON:0003331 ! submucosa of colon
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001157 ! transverse colon
relationship: part_of UBERON:0001157 ! transverse colon

[Term]
id: UBERON:0004931
name: submucosa of descending colon
def: "A submucosa that is part of a descending colon [Automatically generated definition]." []
synonym: "descending colon submucosa" EXACT []
is_a: UBERON:0003331 ! submucosa of colon
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001158 ! descending colon
relationship: part_of UBERON:0001158 ! descending colon

[Term]
id: UBERON:0004932
name: submucosa of sigmoid colon
def: "A submucosa that is part of a sigmoid colon [Automatically generated definition]." []
synonym: "sigmoid colon submucosa" EXACT []
is_a: UBERON:0003331 ! submucosa of colon
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon

[Term]
id: UBERON:0004933
name: submucosa of fundus of stomach
def: "A submucosa that is part of a fundus of stomach [Automatically generated definition]." []
synonym: "fundus gastricus (ventricularis) submucosa" EXACT []
synonym: "fundus of stomach submucosa" EXACT []
synonym: "stomach fundus submucosa" EXACT []
synonym: "submucosa of fundus gastricus (ventricularis)" EXACT []
synonym: "submucosa of stomach fundus" EXACT []
is_a: UBERON:0001200 ! submucosa of stomach
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach

[Term]
id: UBERON:0004935
name: submucosa of cardia of stomach
def: "A submucosa that is part of a cardia of stomach [Automatically generated definition]." []
synonym: "cardia of stomach submucosa" EXACT []
synonym: "cardial part of stomach submucosa" EXACT []
synonym: "gastric cardia submucosa" EXACT []
synonym: "pars cardiaca (gaster) submucosa" EXACT []
synonym: "stomach cardiac region submucosa" EXACT []
synonym: "submucosa of cardial part of stomach" EXACT []
synonym: "submucosa of gastric cardia" EXACT []
synonym: "submucosa of pars cardiaca (gaster)" EXACT []
synonym: "submucosa of stomach cardiac region" EXACT []
is_a: UBERON:0001200 ! submucosa of stomach
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001162 ! cardia of stomach
relationship: part_of UBERON:0001162 ! cardia of stomach

[Term]
id: UBERON:0004936
name: submucosa of pyloric antrum
def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." []
synonym: "antrum of stomach submucosa" EXACT []
synonym: "pyloric antrum submucosa" EXACT []
synonym: "stomach pyloric antrum submucosa" EXACT []
synonym: "submucosa of antrum of stomach" EXACT []
synonym: "submucosa of stomach pyloric antrum" EXACT []
is_a: UBERON:0004937 ! submucosa of pylorus
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001165 ! pyloric antrum
relationship: part_of UBERON:0001165 ! pyloric antrum

[Term]
id: UBERON:0004937
name: submucosa of pylorus
def: "A submucosa that is part of a pylorus [Automatically generated definition]." []
synonym: "pyloric part of stomach submucosa" EXACT []
synonym: "pyloric submucosa" EXACT []
synonym: "pylorus submucosa" EXACT []
synonym: "stomach pyloric region submucosa" EXACT []
synonym: "submucosa of pyloric part of stomach" EXACT []
synonym: "submucosa of stomach pyloric region" EXACT []
is_a: UBERON:0001200 ! submucosa of stomach
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0004938
name: submucosa of biliary tree
def: "A submucosa that is part of a biliary tree [Automatically generated definition]." []
synonym: "biliary tract submucosa" EXACT []
synonym: "biliary tree submucosa" EXACT []
synonym: "submucosa of biliary tract" EXACT []
is_a: UBERON:0000009 ! submucosa
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001173 ! biliary tree
relationship: part_of UBERON:0001173 ! biliary tree

[Term]
id: UBERON:0004943
name: submucosa of urinary bladder
def: "The submucous layer of the wall of the urinary bladder." []
synonym: "bladder submucosa" EXACT []
synonym: "submucosa of bladder" EXACT []
synonym: "submucous layer of urinary bladder" RELATED []
synonym: "tela submucosa (Vesica urinaria)" EXACT []
synonym: "tela submucosa vesicae" EXACT []
synonym: "tela submucosa vesicae urinariae" EXACT []
synonym: "urinary bladder submucosa" EXACT []
is_a: UBERON:0000009 ! submucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001256 ! wall of urinary bladder

[Term]
id: UBERON:0004944
name: submucosa of trigone of urinary bladder
def: "A submucosa that is part of a trigone of urinary bladder [Automatically generated definition]." []
synonym: "deep trigone submucosa" EXACT []
synonym: "Lieutaud ' s trigone submucosa" EXACT []
synonym: "submucosa of deep trigone" EXACT []
synonym: "submucosa of Lieutaud ' s trigone" EXACT []
synonym: "submucosa of trigone of bladder" EXACT []
synonym: "submucosa of urinary bladder trigone" EXACT []
synonym: "submucosa of vesical trigone" EXACT []
synonym: "trigone of bladder submucosa" EXACT []
synonym: "trigone of urinary bladder submucosa" EXACT []
synonym: "urinary bladder trigone submucosa" EXACT []
synonym: "vesical trigone submucosa" EXACT []
is_a: UBERON:0004943 ! submucosa of urinary bladder
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder
relationship: part_of UBERON:0001257 ! trigone of urinary bladder

[Term]
id: UBERON:0004945
name: submucosa of neck of urinary bladder
def: "A submucosa that is part of a neck of urinary bladder [Automatically generated definition]." []
synonym: "bladder neck submucosa" EXACT []
synonym: "neck of bladder submucosa" EXACT []
synonym: "neck of urinary bladder submucosa" EXACT []
synonym: "submucosa of bladder neck" EXACT []
synonym: "submucosa of neck of bladder" EXACT []
synonym: "submucosa of urinary bladder neck" EXACT []
synonym: "submucosa of vesical neck" EXACT []
synonym: "urinary bladder neck submucosa" EXACT []
synonym: "vesical neck submucosa" EXACT []
is_a: UBERON:0004943 ! submucosa of urinary bladder
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001258 ! neck of urinary bladder
relationship: part_of UBERON:0001258 ! neck of urinary bladder

[Term]
id: UBERON:0004946
name: submucosa of ileum
def: "A submucosa that is part of a ileum [Automatically generated definition]." []
synonym: "ileal submucosa" EXACT []
synonym: "ileum submucosa" EXACT []
is_a: UBERON:0001205 ! submucosa of small intestine
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: UBERON:0004952
name: submucosa of bronchiole
def: "A submucosa that is part of a bronchiole [Automatically generated definition]." []
synonym: "bronchiole submucosa" EXACT []
synonym: "lobular bronchiole submucosa" EXACT []
synonym: "submucosa of lobular bronchiole" EXACT []
is_a: UBERON:0001957 ! submucosa of bronchus
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0002186 ! bronchiole

[Term]
id: UBERON:0004980
name: mucosa of ureter
def: "A mucosa that is part of a ureter [Automatically generated definition]." []
synonym: "mucosa of organ of ureter" EXACT []
synonym: "mucosal layer of ureter" EXACT []
synonym: "mucous membrane of ureter" EXACT []
synonym: "organ mucosa of ureter" EXACT []
synonym: "tunica mucosa (ureter)" EXACT []
synonym: "tunica mucosa ureteris" EXACT []
synonym: "ureter mucosa" EXACT []
synonym: "ureter mucosa of organ" EXACT []
synonym: "ureter mucous membrane" EXACT []
synonym: "ureter organ mucosa" EXACT []
synonym: "ureteral mucosa" EXACT []
synonym: "ureteric mucosa" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0009916 ! wall of ureter

[Term]
id: UBERON:0004983
name: mucosa of vagina
def: "A mucosa that is part of a vagina [Automatically generated definition]." []
synonym: "mucosa of organ of vagina" EXACT []
synonym: "mucous membrane of vagina" EXACT []
synonym: "organ mucosa of vagina" EXACT []
synonym: "tunica mucosa vaginae" EXACT []
synonym: "vagina mucosa" EXACT []
synonym: "vagina mucosa of organ" EXACT []
synonym: "vagina mucous membrane" EXACT []
synonym: "vagina organ mucosa" EXACT []
synonym: "vaginal mucosa" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0019042 ! reproductive system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0004984
name: mucosa of seminal vesicle
def: "A mucosa that is part of a seminal vesicle [Automatically generated definition]." []
synonym: "mucosa of organ of seminal gland" EXACT []
synonym: "mucosa of organ of seminal vesicle" EXACT []
synonym: "mucosa of seminal gland" EXACT []
synonym: "mucous membrane of seminal gland" EXACT []
synonym: "mucous membrane of seminal vesicle" EXACT []
synonym: "organ mucosa of seminal gland" EXACT []
synonym: "organ mucosa of seminal vesicle" EXACT []
synonym: "seminal gland mucosa" EXACT []
synonym: "seminal gland mucosa of organ" EXACT []
synonym: "seminal gland mucous membrane" EXACT []
synonym: "seminal gland organ mucosa" EXACT []
synonym: "seminal vesicle mucosa" EXACT []
synonym: "seminal vesicle mucosa of organ" EXACT []
synonym: "seminal vesicle mucous membrane" EXACT []
synonym: "seminal vesicle organ mucosa" EXACT []
synonym: "tunica mucosa glandulae vesiculosae" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0019042 ! reproductive system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle

[Term]
id: UBERON:0004988
name: mucosa of cystic duct
def: "A mucosa that is part of a cystic duct [Automatically generated definition]." []
synonym: "cystic duct mucosa" EXACT []
synonym: "cystic duct mucosa of organ" EXACT []
synonym: "cystic duct mucous membrane" EXACT []
synonym: "cystic duct organ mucosa" EXACT []
synonym: "cystic ductal mucosa" EXACT []
synonym: "mucosa of organ of cystic duct" EXACT []
synonym: "mucous membrane of cystic duct" EXACT []
synonym: "organ mucosa of cystic duct" EXACT []
is_a: UBERON:0004999 ! mucosa of biliary tree
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001152 ! cystic duct
relationship: part_of UBERON:0001152 ! cystic duct

[Term]
id: UBERON:0004989
name: mucosa of appendix
def: "A mucosa that is part of an appendix [Automatically generated definition]." []
synonym: "appendiceal mucous membrane" EXACT []
synonym: "appendix mucosa" EXACT []
synonym: "appendix mucosa of organ" EXACT []
synonym: "appendix mucous membrane" EXACT []
synonym: "appendix organ mucosa" EXACT []
synonym: "caecal appendix mucosa" EXACT []
synonym: "caecal appendix mucosa of organ" EXACT []
synonym: "caecal appendix mucous membrane" EXACT []
synonym: "caecal appendix organ mucosa" EXACT []
synonym: "mucosa of caecal appendix" EXACT []
synonym: "mucosa of organ of appendix" EXACT []
synonym: "mucosa of organ of caecal appendix" EXACT []
synonym: "mucosa of organ of vermiform appendix" EXACT []
synonym: "mucosa of organ of vermix" EXACT []
synonym: "mucosa of vermiform appendix" EXACT []
synonym: "mucosa of vermix" EXACT []
synonym: "mucous membrane of appendix" EXACT []
synonym: "mucous membrane of caecal appendix" EXACT []
synonym: "mucous membrane of vermiform appendix" EXACT []
synonym: "mucous membrane of vermix" EXACT []
synonym: "organ mucosa of appendix" EXACT []
synonym: "organ mucosa of caecal appendix" EXACT []
synonym: "organ mucosa of vermiform appendix" EXACT []
synonym: "organ mucosa of vermix" EXACT []
synonym: "vermiform appendix mucosa" EXACT []
synonym: "vermiform appendix mucosa of organ" EXACT []
synonym: "vermiform appendix mucous membrane" EXACT []
synonym: "vermiform appendix organ mucosa" EXACT []
synonym: "vermix mucosa" EXACT []
synonym: "vermix mucosa of organ" EXACT []
synonym: "vermix mucous membrane" EXACT []
synonym: "vermix organ mucosa" EXACT []
is_a: UBERON:0000314 ! cecum mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: UBERON:0004990
name: mucosa of ascending colon
def: "A mucosa that is part of an ascending colon [Automatically generated definition]." []
synonym: "ascending colon mucosa" EXACT []
synonym: "ascending colon mucosa of organ" EXACT []
synonym: "ascending colon mucous membrane" EXACT []
synonym: "ascending colon organ mucosa" EXACT []
synonym: "mucosa of organ of ascending colon" EXACT []
synonym: "mucous membrane of ascending colon" EXACT []
synonym: "organ mucosa of ascending colon" EXACT []
is_a: UBERON:0000317 ! colonic mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001156 ! ascending colon
relationship: part_of UBERON:0001156 ! ascending colon

[Term]
id: UBERON:0004991
name: mucosa of transverse colon
def: "A mucosa that is part of a transverse colon [Automatically generated definition]." []
synonym: "mucosa of organ of transverse colon" EXACT []
synonym: "mucous membrane of transverse colon" EXACT []
synonym: "organ mucosa of transverse colon" EXACT []
synonym: "transverse colon mucosa" EXACT []
synonym: "transverse colon mucosa of organ" EXACT []
synonym: "transverse colon mucous membrane" EXACT []
synonym: "transverse colon organ mucosa" EXACT []
is_a: UBERON:0000317 ! colonic mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001157 ! transverse colon
relationship: part_of UBERON:0001157 ! transverse colon

[Term]
id: UBERON:0004992
name: mucosa of descending colon
def: "A mucosa that is part of a descending colon [Automatically generated definition]." []
synonym: "descending colon mucosa" EXACT []
synonym: "descending colon mucosa of organ" EXACT []
synonym: "descending colon mucous membrane" EXACT []
synonym: "descending colon organ mucosa" EXACT []
synonym: "mucosa of organ of descending colon" EXACT []
synonym: "mucous membrane of descending colon" EXACT []
synonym: "organ mucosa of descending colon" EXACT []
is_a: UBERON:0000317 ! colonic mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001158 ! descending colon
relationship: part_of UBERON:0001158 ! descending colon

[Term]
id: UBERON:0004993
name: mucosa of sigmoid colon
def: "A mucosa that is part of a sigmoid colon [Automatically generated definition]." []
synonym: "mucosa of organ of sigmoid colon" EXACT []
synonym: "mucous membrane of sigmoid colon" EXACT []
synonym: "organ mucosa of sigmoid colon" EXACT []
synonym: "sigmoid colon mucosa" EXACT []
synonym: "sigmoid colon mucosa of organ" EXACT []
synonym: "sigmoid colon mucous membrane" EXACT []
synonym: "sigmoid colon organ mucosa" EXACT []
is_a: UBERON:0000317 ! colonic mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon

[Term]
id: UBERON:0004994
name: mucosa of fundus of stomach
def: "A mucosa that is part of a fundus of stomach [Automatically generated definition]." []
synonym: "fundus gastricus (ventricularis) mucosa" EXACT []
synonym: "fundus gastricus (ventricularis) mucosa of organ" EXACT []
synonym: "fundus gastricus (ventricularis) mucous membrane" EXACT []
synonym: "fundus gastricus (ventricularis) organ mucosa" EXACT []
synonym: "fundus of stomach mucosa" EXACT []
synonym: "fundus of stomach mucosa of organ" EXACT []
synonym: "fundus of stomach mucous membrane" EXACT []
synonym: "fundus of stomach organ mucosa" EXACT []
synonym: "mucosa of fundus gastricus (ventricularis)" EXACT []
synonym: "mucosa of organ of fundus gastricus (ventricularis)" EXACT []
synonym: "mucosa of organ of fundus of stomach" EXACT []
synonym: "mucosa of organ of stomach fundus" EXACT []
synonym: "mucosa of stomach fundus" EXACT []
synonym: "mucous membrane of fundus gastricus (ventricularis)" EXACT []
synonym: "mucous membrane of fundus of stomach" EXACT []
synonym: "mucous membrane of stomach fundus" EXACT []
synonym: "organ mucosa of fundus gastricus (ventricularis)" EXACT []
synonym: "organ mucosa of fundus of stomach" EXACT []
synonym: "organ mucosa of stomach fundus" EXACT []
synonym: "stomach fundus mucosa" EXACT []
synonym: "stomach fundus mucosa of organ" EXACT []
synonym: "stomach fundus mucous membrane" EXACT []
synonym: "stomach fundus organ mucosa" EXACT []
is_a: UBERON:0001199 ! mucosa of stomach
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach

[Term]
id: UBERON:0004996
name: mucosa of cardia of stomach
def: "A mucosa that is part of a cardia of stomach [Automatically generated definition]." []
synonym: "cardia of stomach mucosa" EXACT []
synonym: "cardia of stomach mucosa of organ" EXACT []
synonym: "cardia of stomach mucous membrane" EXACT []
synonym: "cardia of stomach organ mucosa" EXACT []
synonym: "cardial part of stomach mucosa" EXACT []
synonym: "cardial part of stomach mucosa of organ" EXACT []
synonym: "cardial part of stomach mucous membrane" EXACT []
synonym: "cardial part of stomach organ mucosa" EXACT []
synonym: "gastric cardia mucosa" EXACT []
synonym: "gastric cardia mucosa of organ" EXACT []
synonym: "gastric cardia mucous membrane" EXACT []
synonym: "gastric cardia organ mucosa" EXACT []
synonym: "mucosa of cardial part of stomach" EXACT []
synonym: "mucosa of gastric cardia" EXACT []
synonym: "mucosa of organ of cardia of stomach" EXACT []
synonym: "mucosa of organ of cardial part of stomach" EXACT []
synonym: "mucosa of organ of gastric cardia" EXACT []
synonym: "mucosa of organ of pars cardiaca (gaster)" EXACT []
synonym: "mucosa of organ of stomach cardiac region" EXACT []
synonym: "mucosa of pars cardiaca (gaster)" EXACT []
synonym: "mucosa of stomach cardiac region" EXACT []
synonym: "mucous membrane of cardia of stomach" EXACT []
synonym: "mucous membrane of cardial part of stomach" EXACT []
synonym: "mucous membrane of gastric cardia" EXACT []
synonym: "mucous membrane of pars cardiaca (gaster)" EXACT []
synonym: "mucous membrane of stomach cardiac region" EXACT []
synonym: "organ mucosa of cardia of stomach" EXACT []
synonym: "organ mucosa of cardial part of stomach" EXACT []
synonym: "organ mucosa of gastric cardia" EXACT []
synonym: "organ mucosa of pars cardiaca (gaster)" EXACT []
synonym: "organ mucosa of stomach cardiac region" EXACT []
synonym: "pars cardiaca (gaster) mucosa" EXACT []
synonym: "pars cardiaca (gaster) mucosa of organ" EXACT []
synonym: "pars cardiaca (gaster) mucous membrane" EXACT []
synonym: "pars cardiaca (gaster) organ mucosa" EXACT []
synonym: "stomach cardiac region mucosa" EXACT []
synonym: "stomach cardiac region mucosa of organ" EXACT []
synonym: "stomach cardiac region mucous membrane" EXACT []
synonym: "stomach cardiac region organ mucosa" EXACT []
is_a: UBERON:0001199 ! mucosa of stomach
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001162 ! cardia of stomach
relationship: part_of UBERON:0001162 ! cardia of stomach

[Term]
id: UBERON:0004997
name: mucosa of pyloric antrum
def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." []
synonym: "antral mucosa" EXACT []
synonym: "antrum of stomach mucosa" EXACT []
synonym: "antrum of stomach mucosa of organ" EXACT []
synonym: "antrum of stomach mucous membrane" EXACT []
synonym: "antrum of stomach organ mucosa" EXACT []
synonym: "gastric antrum mucosa" RELATED []
synonym: "mucosa of antrum of stomach" EXACT []
synonym: "mucosa of organ of antrum of stomach" EXACT []
synonym: "mucosa of organ of pyloric antrum" EXACT []
synonym: "mucosa of organ of stomach pyloric antrum" EXACT []
synonym: "mucosa of stomach pyloric antrum" EXACT []
synonym: "mucous membrane of antrum of stomach" EXACT []
synonym: "mucous membrane of pyloric antrum" EXACT []
synonym: "mucous membrane of stomach pyloric antrum" EXACT []
synonym: "organ mucosa of antrum of stomach" EXACT []
synonym: "organ mucosa of pyloric antrum" EXACT []
synonym: "organ mucosa of stomach pyloric antrum" EXACT []
synonym: "pyloric antrum mucosa" EXACT []
synonym: "pyloric antrum mucosa of organ" EXACT []
synonym: "pyloric antrum mucous membrane" EXACT []
synonym: "pyloric antrum organ mucosa" EXACT []
synonym: "stomach pyloric antrum mucosa" EXACT []
synonym: "stomach pyloric antrum mucosa of organ" EXACT []
synonym: "stomach pyloric antrum mucous membrane" EXACT []
synonym: "stomach pyloric antrum organ mucosa" EXACT []
is_a: UBERON:0004998 ! mucosa of pylorus
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001165 ! pyloric antrum
relationship: part_of UBERON:0001165 ! pyloric antrum
relationship: part_of UBERON:0004998 ! mucosa of pylorus

[Term]
id: UBERON:0004998
name: mucosa of pylorus
def: "A mucosa that is part of a pylorus [Automatically generated definition]." []
synonym: "antropyloric mucosa" RELATED []
synonym: "mucosa of organ of pyloric part of stomach" EXACT []
synonym: "mucosa of organ of pylorus" EXACT []
synonym: "mucosa of organ of stomach pyloric region" EXACT []
synonym: "mucosa of pyloric part of stomach" EXACT []
synonym: "mucosa of stomach pyloric region" EXACT []
synonym: "mucous membrane of pyloric part of stomach" EXACT []
synonym: "mucous membrane of pylorus" EXACT []
synonym: "mucous membrane of stomach pyloric region" EXACT []
synonym: "organ mucosa of pyloric part of stomach" EXACT []
synonym: "organ mucosa of pylorus" EXACT []
synonym: "organ mucosa of stomach pyloric region" EXACT []
synonym: "pyloric part of stomach mucosa" EXACT []
synonym: "pyloric part of stomach mucosa of organ" EXACT []
synonym: "pyloric part of stomach mucous membrane" EXACT []
synonym: "pyloric part of stomach organ mucosa" EXACT []
synonym: "pylorus mucosa" EXACT []
synonym: "pylorus mucosa of organ" EXACT []
synonym: "pylorus mucous membrane" EXACT []
synonym: "pylorus organ mucosa" EXACT []
synonym: "stomach pyloric region mucosa" EXACT []
synonym: "stomach pyloric region mucosa of organ" EXACT []
synonym: "stomach pyloric region mucous membrane" EXACT []
synonym: "stomach pyloric region organ mucosa" EXACT []
is_a: UBERON:0001199 ! mucosa of stomach
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0004999
name: mucosa of biliary tree
def: "A mucosa that is part of a biliary tree [Automatically generated definition]." []
synonym: "biliary tract mucosa" EXACT []
synonym: "biliary tract mucosa of organ" EXACT []
synonym: "biliary tract mucous membrane" EXACT []
synonym: "biliary tract organ mucosa" EXACT []
synonym: "biliary tree mucosa" EXACT []
synonym: "biliary tree mucosa of organ" EXACT []
synonym: "biliary tree mucous membrane" EXACT []
synonym: "biliary tree organ mucosa" EXACT []
synonym: "mucosa of biliary tract" EXACT []
synonym: "mucosa of organ of biliary tract" EXACT []
synonym: "mucosa of organ of biliary tree" EXACT []
synonym: "mucous membrane of biliary tract" EXACT []
synonym: "mucous membrane of biliary tree" EXACT []
synonym: "organ mucosa of biliary tract" EXACT []
synonym: "organ mucosa of biliary tree" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001173 ! biliary tree
relationship: part_of UBERON:0001173 ! biliary tree

[Term]
id: UBERON:0005006
name: mucosa of renal pelvis
def: "A mucosa that is part of a renal pelvis [Automatically generated definition]." []
synonym: "kidney pelvis mucosa" EXACT []
synonym: "kidney pelvis mucosa of organ" EXACT []
synonym: "kidney pelvis mucous membrane" EXACT []
synonym: "kidney pelvis organ mucosa" EXACT []
synonym: "mucosa of kidney pelvis" EXACT []
synonym: "mucosa of organ of kidney pelvis" EXACT []
synonym: "mucosa of organ of pelvis of ureter" EXACT []
synonym: "mucosa of organ of renal pelvis" EXACT []
synonym: "mucosa of pelvis of ureter" EXACT []
synonym: "mucous membrane of kidney pelvis" EXACT []
synonym: "mucous membrane of pelvis of ureter" EXACT []
synonym: "mucous membrane of renal pelvis" EXACT []
synonym: "organ mucosa of kidney pelvis" EXACT []
synonym: "organ mucosa of pelvis of ureter" EXACT []
synonym: "organ mucosa of renal pelvis" EXACT []
synonym: "pelvis of ureter mucosa" EXACT []
synonym: "pelvis of ureter mucosa of organ" EXACT []
synonym: "pelvis of ureter mucous membrane" EXACT []
synonym: "pelvis of ureter organ mucosa" EXACT []
synonym: "renal pelvic mucosa" EXACT []
synonym: "renal pelvis mucosa" EXACT []
synonym: "renal pelvis mucosa of organ" EXACT []
synonym: "renal pelvis mucous membrane" EXACT []
synonym: "renal pelvis organ mucosa" EXACT []
synonym: "tunica mucosa pelvis renalis" EXACT []
is_a: UBERON:0004980 ! mucosa of ureter
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis

[Term]
id: UBERON:0005009
name: mucosa of trigone of urinary bladder
def: "A mucosa that is part of a trigone of urinary bladder [Automatically generated definition]." []
synonym: "deep trigone mucosa" EXACT []
synonym: "deep trigone mucosa of organ" EXACT []
synonym: "deep trigone mucous membrane" EXACT []
synonym: "deep trigone organ mucosa" EXACT []
synonym: "Lieutaud ' s trigone mucosa" EXACT []
synonym: "Lieutaud ' s trigone mucosa of organ" EXACT []
synonym: "Lieutaud ' s trigone mucous membrane" EXACT []
synonym: "Lieutaud ' s trigone organ mucosa" EXACT []
synonym: "mucosa of deep trigone" EXACT []
synonym: "mucosa of Lieutaud ' s trigone" EXACT []
synonym: "mucosa of organ of deep trigone" EXACT []
synonym: "mucosa of organ of Lieutaud ' s trigone" EXACT []
synonym: "mucosa of organ of trigone of bladder" EXACT []
synonym: "mucosa of organ of trigone of urinary bladder" EXACT []
synonym: "mucosa of organ of urinary bladder trigone" EXACT []
synonym: "mucosa of organ of vesical trigone" EXACT []
synonym: "mucosa of trigone of bladder" EXACT []
synonym: "mucosa of urinary bladder trigone" EXACT []
synonym: "mucosa of vesical trigone" EXACT []
synonym: "mucous membrane of deep trigone" EXACT []
synonym: "mucous membrane of Lieutaud ' s trigone" EXACT []
synonym: "mucous membrane of trigone of bladder" EXACT []
synonym: "mucous membrane of trigone of urinary bladder" EXACT []
synonym: "mucous membrane of urinary bladder trigone" EXACT []
synonym: "mucous membrane of vesical trigone" EXACT []
synonym: "organ mucosa of deep trigone" EXACT []
synonym: "organ mucosa of Lieutaud ' s trigone" EXACT []
synonym: "organ mucosa of trigone of bladder" EXACT []
synonym: "organ mucosa of trigone of urinary bladder" EXACT []
synonym: "organ mucosa of urinary bladder trigone" EXACT []
synonym: "organ mucosa of vesical trigone" EXACT []
synonym: "trigone of bladder mucosa" EXACT []
synonym: "trigone of bladder mucosa of organ" EXACT []
synonym: "trigone of bladder mucous membrane" EXACT []
synonym: "trigone of bladder organ mucosa" EXACT []
synonym: "trigone of urinary bladder mucosa" EXACT []
synonym: "trigone of urinary bladder mucosa of organ" EXACT []
synonym: "trigone of urinary bladder mucous membrane" EXACT []
synonym: "trigone of urinary bladder organ mucosa" EXACT []
synonym: "urinary bladder trigone mucosa" EXACT []
synonym: "urinary bladder trigone mucosa of organ" EXACT []
synonym: "urinary bladder trigone mucous membrane" EXACT []
synonym: "urinary bladder trigone organ mucosa" EXACT []
synonym: "vesical trigone mucosa" EXACT []
synonym: "vesical trigone mucosa of organ" EXACT []
synonym: "vesical trigone mucous membrane" EXACT []
synonym: "vesical trigone organ mucosa" EXACT []
is_a: UBERON:0001259 ! mucosa of urinary bladder
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder
relationship: part_of UBERON:0001257 ! trigone of urinary bladder

[Term]
id: UBERON:0005010
name: mucosa of neck of urinary bladder
def: "A mucosa that is part of a neck of urinary bladder [Automatically generated definition]." []
synonym: "bladder neck mucosa" EXACT []
synonym: "bladder neck mucosa of organ" EXACT []
synonym: "bladder neck mucous membrane" EXACT []
synonym: "bladder neck organ mucosa" EXACT []
synonym: "mucosa of bladder neck" EXACT []
synonym: "mucosa of neck of bladder" EXACT []
synonym: "mucosa of organ of bladder neck" EXACT []
synonym: "mucosa of organ of neck of bladder" EXACT []
synonym: "mucosa of organ of neck of urinary bladder" EXACT []
synonym: "mucosa of organ of urinary bladder neck" EXACT []
synonym: "mucosa of organ of vesical neck" EXACT []
synonym: "mucosa of urinary bladder neck" EXACT []
synonym: "mucosa of vesical neck" EXACT []
synonym: "mucous membrane of bladder neck" EXACT []
synonym: "mucous membrane of neck of bladder" EXACT []
synonym: "mucous membrane of neck of urinary bladder" EXACT []
synonym: "mucous membrane of urinary bladder neck" EXACT []
synonym: "mucous membrane of vesical neck" EXACT []
synonym: "neck of bladder mucosa" EXACT []
synonym: "neck of bladder mucosa of organ" EXACT []
synonym: "neck of bladder mucous membrane" EXACT []
synonym: "neck of bladder organ mucosa" EXACT []
synonym: "neck of urinary bladder mucosa" EXACT []
synonym: "neck of urinary bladder mucosa of organ" EXACT []
synonym: "neck of urinary bladder mucous membrane" EXACT []
synonym: "neck of urinary bladder organ mucosa" EXACT []
synonym: "organ mucosa of bladder neck" EXACT []
synonym: "organ mucosa of neck of bladder" EXACT []
synonym: "organ mucosa of neck of urinary bladder" EXACT []
synonym: "organ mucosa of urinary bladder neck" EXACT []
synonym: "organ mucosa of vesical neck" EXACT []
synonym: "urinary bladder neck mucosa" EXACT []
synonym: "urinary bladder neck mucosa of organ" EXACT []
synonym: "urinary bladder neck mucous membrane" EXACT []
synonym: "vesical neck mucosa" EXACT []
synonym: "vesical neck mucosa of organ" EXACT []
synonym: "vesical neck mucous membrane" EXACT []
synonym: "vesical neck organ mucosa" EXACT []
is_a: UBERON:0001259 ! mucosa of urinary bladder
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001258 ! neck of urinary bladder
relationship: part_of UBERON:0001258 ! neck of urinary bladder

[Term]
id: UBERON:0005013
name: mucosa of male urethra
def: "A mucosa that is part of a male urethra [Automatically generated definition]." []
synonym: "male urethra mucosa" EXACT []
synonym: "male urethra mucosa of organ" EXACT []
synonym: "male urethra mucous membrane" EXACT []
synonym: "male urethra organ mucosa" EXACT []
synonym: "mucosa of organ of male urethra" EXACT []
synonym: "mucous membrane of male urethra" EXACT []
synonym: "organ mucosa of male urethra" EXACT []
is_a: UBERON:0012299 ! mucosa of urethra
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001333 ! male urethra
relationship: part_of UBERON:0001333 ! male urethra

[Term]
id: UBERON:0005014
name: mucosa of female urethra
def: "A mucosa that is part of a female urethra [Automatically generated definition]." []
synonym: "female urethra mucosa" EXACT []
synonym: "female urethra mucosa of organ" EXACT []
synonym: "female urethra mucous membrane" EXACT []
synonym: "female urethra organ mucosa" EXACT []
synonym: "mucosa of organ of female urethra" EXACT []
synonym: "mucous membrane of female urethra" EXACT []
synonym: "organ mucosa of female urethra" EXACT []
is_a: UBERON:0012299 ! mucosa of urethra
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: part_of UBERON:0001334 ! female urethra

[Term]
id: UBERON:0005017
name: mucosa of lacrimal sac
def: "A mucosa that is part of a lacrimal sac [Automatically generated definition]." []
synonym: "lacrimal sac mucosa" EXACT []
synonym: "lacrimal sac mucosa of organ" EXACT []
synonym: "lacrimal sac mucous membrane" EXACT []
synonym: "lacrimal sac organ mucosa" EXACT []
synonym: "mucosa of organ of lacrimal sac" EXACT []
synonym: "mucous membrane of lacrimal sac" EXACT []
synonym: "organ mucosa of lacrimal sac" EXACT []
is_a: UBERON:0005043 ! mucosa of nasolacrimal duct
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001351 ! lacrimal sac
relationship: part_of UBERON:0001351 ! lacrimal sac

[Term]
id: UBERON:0005020
name: mucosa of tongue
def: "A mucosa that is part of a tongue [Automatically generated definition]." []
synonym: "lingual mucosa" EXACT []
synonym: "mucosa of organ of tongue" EXACT []
synonym: "mucous membrane of tongue" EXACT []
synonym: "organ mucosa of tongue" EXACT []
synonym: "tongue mucosa" EXACT []
synonym: "tongue mucosa of organ" EXACT []
synonym: "tongue mucous membrane" EXACT []
synonym: "tongue organ mucosa" EXACT []
synonym: "tunica mucosa linguae" EXACT []
is_a: UBERON:0003729 ! mouth mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0005022
name: mucosa of nasopharynx
def: "A mucosa that is part of a nasopharynx [Automatically generated definition]." []
synonym: "mucosa of nasal part of pharynx" EXACT []
synonym: "mucosa of organ of nasal part of pharynx" EXACT []
synonym: "mucosa of organ of nasopharynx" EXACT []
synonym: "mucosa of organ of rhinopharynx" EXACT []
synonym: "mucosa of rhinopharynx" EXACT []
synonym: "mucous membrane of nasal part of pharynx" EXACT []
synonym: "mucous membrane of nasopharynx" EXACT []
synonym: "mucous membrane of rhinopharynx" EXACT []
synonym: "nasal part of pharynx mucosa" EXACT []
synonym: "nasal part of pharynx mucosa of organ" EXACT []
synonym: "nasal part of pharynx mucous membrane" EXACT []
synonym: "nasal part of pharynx organ mucosa" EXACT []
synonym: "nasopharynx mucosa" EXACT []
synonym: "nasopharynx mucosa of organ" EXACT []
synonym: "nasopharynx mucous membrane" EXACT []
synonym: "nasopharynx organ mucosa" EXACT []
synonym: "organ mucosa of nasal part of pharynx" EXACT []
synonym: "organ mucosa of nasopharynx" EXACT []
synonym: "organ mucosa of rhinopharynx" EXACT []
synonym: "rhinopharynx mucosa" EXACT []
synonym: "rhinopharynx mucosa of organ" EXACT []
synonym: "rhinopharynx mucous membrane" EXACT []
synonym: "rhinopharynx organ mucosa" EXACT []
is_a: UBERON:0000355 ! pharyngeal mucosa
is_a: UBERON:0000379 ! tracheal mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx

[Term]
id: UBERON:0005026
name: mucosa of middle ear
def: "A mucosa that is part of a middle ear [Automatically generated definition]." []
synonym: "middle ear mucosa" EXACT []
synonym: "middle ear mucosa of organ" EXACT []
synonym: "middle ear mucous membrane" EXACT []
synonym: "middle ear organ mucosa" EXACT []
synonym: "mucosa of organ of middle ear" EXACT []
synonym: "mucosa of tympanic cavity" EXACT []
synonym: "mucous membrane of middle ear" EXACT []
synonym: "organ mucosa of middle ear" EXACT []
synonym: "tunica mucosa cavitatis tympanicae" EXACT []
is_a: UBERON:0000344 ! mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001756 ! middle ear
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0005029
name: mucosa of lacrimal canaliculus
def: "A mucosa that is part of a lacrimal canaliculus [Automatically generated definition]." []
synonym: "lacrimal canalicular mucosa" EXACT []
synonym: "lacrimal canaliculus mucosa" EXACT []
synonym: "lacrimal canaliculus mucosa of organ" EXACT []
synonym: "lacrimal canaliculus mucous membrane" EXACT []
synonym: "lacrimal canaliculus organ mucosa" EXACT []
synonym: "mucosa of organ of lacrimal canaliculus" EXACT []
synonym: "mucous membrane of lacrimal canaliculus" EXACT []
synonym: "organ mucosa of lacrimal canaliculus" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus
relationship: part_of UBERON:0001770 ! lacrimal canaliculus

[Term]
id: UBERON:0005033
name: mucosa of gallbladder
def: "A mucosa that is part of a gallbladder [Automatically generated definition]." []
synonym: "gall bladder mucosa" EXACT []
synonym: "gall bladder mucosa of organ" EXACT []
synonym: "gall bladder mucous membrane" EXACT []
synonym: "gall bladder organ mucosa" EXACT []
synonym: "gallbladder mucosa" EXACT []
synonym: "gallbladder mucosa of organ" EXACT []
synonym: "gallbladder mucous membrane" EXACT []
synonym: "gallbladder organ mucosa" EXACT []
synonym: "mucosa of gall bladder" EXACT []
synonym: "mucosa of organ of gall bladder" EXACT []
synonym: "mucosa of organ of gallbladder" EXACT []
synonym: "mucous membrane of gall bladder" EXACT []
synonym: "mucous membrane of gallbladder" EXACT []
synonym: "organ mucosa of gall bladder" EXACT []
synonym: "organ mucosa of gallbladder" EXACT []
synonym: "tunica mucosa (vesica biliaris)" EXACT []
synonym: "tunica mucosa vesicae biliaris" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: UBERON:0005039
name: mucosa of bronchiole
def: "A mucosa that is part of a bronchiole [Automatically generated definition]." []
synonym: "bronchiole mucosa" EXACT []
synonym: "bronchiole mucosa of organ" EXACT []
synonym: "bronchiole mucous membrane" EXACT []
synonym: "bronchiole organ mucosa" EXACT []
synonym: "lobular bronchiole mucosa" EXACT []
synonym: "lobular bronchiole mucosa of organ" EXACT []
synonym: "lobular bronchiole mucous membrane" EXACT []
synonym: "lobular bronchiole organ mucosa" EXACT []
synonym: "mucosa of lobular bronchiole" EXACT []
synonym: "mucosa of organ of bronchiole" EXACT []
synonym: "mucosa of organ of lobular bronchiole" EXACT []
synonym: "mucous membrane of bronchiole" EXACT []
synonym: "mucous membrane of lobular bronchiole" EXACT []
synonym: "organ mucosa of bronchiole" EXACT []
synonym: "organ mucosa of lobular bronchiole" EXACT []
is_a: UBERON:0000410 ! bronchial mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0002186 ! bronchiole

[Term]
id: UBERON:0005040
name: mucosa of terminal bronchiole
def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." []
synonym: "bronchiolus terminalis mucosa" EXACT []
synonym: "bronchiolus terminalis mucosa of organ" EXACT []
synonym: "bronchiolus terminalis mucous membrane" EXACT []
synonym: "bronchiolus terminalis organ mucosa" EXACT []
synonym: "mucosa of bronchiolus terminalis" EXACT []
synonym: "mucosa of organ of bronchiolus terminalis" EXACT []
synonym: "mucosa of organ of terminal bronchiole" EXACT []
synonym: "mucous membrane of bronchiolus terminalis" EXACT []
synonym: "mucous membrane of terminal bronchiole" EXACT []
synonym: "organ mucosa of bronchiolus terminalis" EXACT []
synonym: "organ mucosa of terminal bronchiole" EXACT []
synonym: "terminal bronchiole mucosa" EXACT []
synonym: "terminal bronchiole mucosa of organ" EXACT []
synonym: "terminal bronchiole mucous membrane" EXACT []
synonym: "terminal bronchiole organ mucosa" EXACT []
is_a: UBERON:0005039 ! mucosa of bronchiole
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002187 ! terminal bronchiole
relationship: part_of UBERON:0002187 ! terminal bronchiole

[Term]
id: UBERON:0005041
name: mucosa of respiratory bronchiole
def: "A mucosa that is part of a respiratory bronchiole [Automatically generated definition]." []
synonym: "bronchiolus respiratorius mucosa" EXACT []
synonym: "bronchiolus respiratorius mucosa of organ" EXACT []
synonym: "bronchiolus respiratorius mucous membrane" EXACT []
synonym: "bronchiolus respiratorius organ mucosa" EXACT []
synonym: "mucosa of bronchiolus respiratorius" EXACT []
synonym: "mucosa of organ of bronchiolus respiratorius" EXACT []
synonym: "mucosa of organ of respiratory bronchiole" EXACT []
synonym: "mucous membrane of bronchiolus respiratorius" EXACT []
synonym: "mucous membrane of respiratory bronchiole" EXACT []
synonym: "organ mucosa of bronchiolus respiratorius" EXACT []
synonym: "organ mucosa of respiratory bronchiole" EXACT []
synonym: "respiratory bronchiole mucosa" EXACT []
synonym: "respiratory bronchiole mucosa of organ" EXACT []
synonym: "respiratory bronchiole mucous membrane" EXACT []
synonym: "respiratory bronchiole organ mucosa" EXACT []
is_a: UBERON:0005039 ! mucosa of bronchiole
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002188 ! respiratory bronchiole
relationship: part_of UBERON:0002188 ! respiratory bronchiole

[Term]
id: UBERON:0005042
name: inner epithelial layer of tympanic membrane
def: "A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane" []
synonym: "mucosa of tympanic membrane" EXACT []
synonym: "mucous layer of tympanic membrane" EXACT []
synonym: "mucous stratum of tympanic membrane" EXACT []
synonym: "tympanic membrane external middle ear cavity epithelial component" EXACT []
synonym: "tympanic membrane mucosa" EXACT []
is_a: UBERON:0009647 ! tympanic membrane epithelium
intersection_of: UBERON:0009647 ! tympanic membrane epithelium
intersection_of: part_of UBERON:0010063 ! tympanic cavity epithelium
relationship: part_of UBERON:0010063 ! tympanic cavity epithelium

[Term]
id: UBERON:0005043
name: mucosa of nasolacrimal duct
def: "A mucosa that is part of a nasolacrimal duct [Automatically generated definition]." []
synonym: "mucosa of organ of nasolacrimal duct" EXACT []
synonym: "mucous membrane of nasolacrimal duct" EXACT []
synonym: "nasolacrimal duct mucosa" EXACT []
synonym: "nasolacrimal duct mucosa of organ" EXACT []
synonym: "nasolacrimal duct mucous membrane" EXACT []
synonym: "nasolacrimal duct organ mucosa" EXACT []
synonym: "nasolacrimal ductal mucosa" EXACT []
synonym: "organ mucosa of nasolacrimal duct" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002392 ! nasolacrimal duct
relationship: part_of UBERON:0002392 ! nasolacrimal duct

[Term]
id: UBERON:0005048
name: mucosa of uterine tube
def: "A mucosa that is part of a fallopian tube [Automatically generated definition]." []
synonym: "fallopian tube mucosa" EXACT []
synonym: "fallopian tube mucosa of organ" EXACT []
synonym: "fallopian tube mucous membrane" EXACT []
synonym: "fallopian tube organ mucosa" EXACT []
synonym: "mucosa of fallopian tube" EXACT []
synonym: "mucosa of organ of fallopian tube" EXACT []
synonym: "mucosa of organ of uterine tube" EXACT []
synonym: "mucosa of oviduct" EXACT []
synonym: "mucous membrane of fallopian tube" EXACT []
synonym: "mucous membrane of uterine tube" EXACT []
synonym: "organ mucosa of fallopian tube" EXACT []
synonym: "organ mucosa of uterine tube" EXACT []
synonym: "tunica mucosa tubae uterinae" EXACT []
synonym: "uterine tubal mucosa" EXACT []
synonym: "uterine tube mucosa" EXACT []
synonym: "uterine tube mucosa of organ" EXACT []
synonym: "uterine tube mucous membrane" EXACT []
synonym: "uterine tube organ mucosa" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0019042 ! reproductive system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0005055
name: zone of long bone
def: "An organ part that is part of a long bone [Automatically generated definition]." []
synonym: "long bone zone" EXACT []
is_a: UBERON:0005913 ! zone of bone organ
intersection_of: UBERON:0005913 ! zone of bone organ
intersection_of: part_of UBERON:0002495 ! long bone
relationship: part_of UBERON:0002495 ! long bone

[Term]
id: UBERON:0005056
name: external female genitalia
def: "An external genitalia that is part of a female reproductive system [Automatically generated definition]." []
synonym: "external female genital organ" EXACT []
synonym: "external genitalia of female reproductive system" EXACT []
synonym: "female external genitalia" EXACT []
synonym: "organa genitalia feminina externa" RELATED []
is_a: UBERON:0003134 ! female reproductive organ
is_a: UBERON:0004176 ! external genitalia
intersection_of: UBERON:0004176 ! external genitalia
intersection_of: part_of UBERON:0000474 ! female reproductive system
disjoint_from: UBERON:0009196 ! indifferent external genitalia
relationship: part_of UBERON:0000474 ! female reproductive system

[Term]
id: UBERON:0005057
name: immune organ
def: "An organ that is part of a immune system [Automatically generated definition]." []
synonym: "immune system organ" EXACT []
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0002405 ! immune system
relationship: part_of UBERON:0002405 ! immune system

[Term]
id: UBERON:0005058
name: hemolymphoid system gland
def: "A gland that is part of a hemolymphoid system [Automatically generated definition]." []
synonym: "haemolymphoid system gland" RELATED []
synonym: "hemopoietic or lymphoid gland" EXACT []
synonym: "hemopoietic or lymphoid organ" BROAD []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0002193 ! hemolymphoid system
relationship: part_of UBERON:0002193 ! hemolymphoid system

[Term]
id: UBERON:0005061
name: neural groove
def: "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0003075 ! neural plate

[Term]
id: UBERON:0005062
name: neural fold
def: "One of the two elevated edges of the neural groove[GO,MP]." []
synonym: "medullary fold" EXACT []
is_a: UBERON:0005157 ! epithelial fold
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0005061 ! neural groove

[Term]
id: UBERON:0005068
name: neural rod
def: "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." []
synonym: "neural tube rod" RELATED []
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0007135 ! neural keel
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0005080
name: metanephric ureteric bud
def: "The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]." []
is_a: UBERON:0000084 ! ureteric bud

[Term]
id: UBERON:0005081
name: ureter ureteric bud
def: "The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]." []
is_a: UBERON:0000084 ! ureteric bud

[Term]
id: UBERON:0005085
name: ectodermal placode
def: "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]" []
synonym: "epithelial placode" RELATED []
is_a: UBERON:0001048 ! primordium
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0005086
name: hair follicle placode
def: "A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate." []
synonym: "hair gem" RELATED []
synonym: "hair germ" RELATED []
synonym: "hair peg" RELATED []
synonym: "hair placode" EXACT []
synonym: "vibrissa placode" NARROW []
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0011817 ! follicle placode
relationship: develops_from UBERON:0001003 ! skin epidermis
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer

[Term]
id: UBERON:0005087
name: tooth placode
def: "An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO]." []
synonym: "dental anlage" EXACT []
synonym: "dental placode" EXACT []
synonym: "dental primordium" EXACT []
synonym: "odontogenic placode" EXACT []
synonym: "tooth anlage" EXACT []
synonym: "tooth germ" RELATED []
synonym: "tooth primordium" EXACT []
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode

[Term]
id: UBERON:0005088
name: sebaceous gland placode
def: "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." []
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer

[Term]
id: UBERON:0005089
name: sweat gland placode
def: "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." []
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:0011272 ! embryonic skin basal layer

[Term]
id: UBERON:0005090
name: muscle structure
def: "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." []
synonym: "muscle" RELATED []
synonym: "muscle element" RELATED []
synonym: "musculus" EXACT []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0005095
name: kidney rudiment
def: "." []
synonym: "kidney anlage" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0007687 ! kidney field
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0005096
name: descending thin limb
def: "The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle[GO]." []
synonym: "descending limb of henle%27s loop" RELATED []
synonym: "descending limb of loop of henle" RELATED []
synonym: "descending thin limb of loop of Henle" EXACT []
synonym: "loop of Henle descending thin limb" EXACT []
synonym: "loop of henle thin descending limb" EXACT []
synonym: "pars descendens (tubulus attenuatus)" EXACT []
synonym: "thin descending limb" EXACT []
synonym: "thin descending limb of loop of henle" RELATED []
synonym: "thin descending limb of the loop of henle" RELATED []
synonym: "thin descending loop of henle" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0001288 ! loop of Henle
relationship: part_of UBERON:0004136 ! intermediate tubule

[Term]
id: UBERON:0005097
name: renal connecting tubule
def: "The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct[GO]." []
synonym: "connecting tubule" EXACT []
synonym: "kidney connecting tubule" EXACT []
synonym: "tubulus renalis arcuatus" RELATED []
is_a: UBERON:0007685 ! region of nephron tubule
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme

[Term]
id: UBERON:0005103
name: mesonephric epithelium
def: "An epithelium that is part of a mesonephros [Automatically generated definition]." []
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005106
name: metanephric tubule
def: "A metanephric tubule is an epithelial tube that is part of the metanephros[GO]." []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005108 ! metanephric epithelium
is_a: UBERON:0006555 ! excretory tube
intersection_of: UBERON:0003914 ! epithelial tube
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005108
name: metanephric epithelium
def: "An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO]." []
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005109
name: metanephric smooth muscle tissue
def: "Any smooth muscle tissue that is part of a metanephros." []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005110
name: metanephric nephron
def: "A metanephric nephron is the functional unit of the metanephros[GO]." []
is_a: UBERON:0001285 ! nephron
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001285 ! nephron
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005111
name: metanephric pyramid
def: "Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO]." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004200 ! kidney pyramid
intersection_of: UBERON:0004200 ! kidney pyramid
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005113
name: metanephric cortex mesenchyme
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0010531 ! metanephros induced blastemal cells

[Term]
id: UBERON:0005114
name: metanephric ascending thin limb
def: "The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent[GO]." []
is_a: UBERON:0004193 ! loop of Henle ascending limb thin segment
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0004193 ! loop of Henle ascending limb thin segment
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005129 ! metanephric distal tubule

[Term]
id: UBERON:0005115
name: metanephric cortical collecting duct
def: "The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO]." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004203 ! cortical collecting duct
intersection_of: UBERON:0004203 ! cortical collecting duct
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004737 ! metanephric collecting duct
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0005116
name: metanephric descending thin limb
def: "It extends to the tip of the metanephric loop of Henle[GO]." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005096 ! descending thin limb
intersection_of: UBERON:0005096 ! descending thin limb
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005130 ! metanephric loop of Henle

[Term]
id: UBERON:0005117
name: metanephric distal convoluted tubule
def: "The metanephric distal convoluted tubule is a portion of the metanephric nephron tubule that connects the metanephric loop of Henle to the collecting duct[GO]." []
is_a: UBERON:0001292 ! distal convoluted tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0001292 ! distal convoluted tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0005119
name: metanephric glomerular mesangium
def: "The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus[GO]." []
is_a: UBERON:0002320 ! glomerular mesangium
intersection_of: UBERON:0002320 ! glomerular mesangium
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005133 ! metanephric glomerulus vasculature

[Term]
id: UBERON:0005122
name: metanephric macula densa
def: "The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus[GO]." []
is_a: UBERON:0002335 ! macula densa
is_a: UBERON:0005134 ! metanephric nephron epithelium
intersection_of: UBERON:0002335 ! macula densa
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004738 ! metanephric juxtaglomerular apparatus

[Term]
id: UBERON:0005124
name: metanephric proximal convoluted tubule
def: "The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule[GO]." []
is_a: UBERON:0001287 ! proximal convoluted tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0001287 ! proximal convoluted tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0005125
name: metanephric proximal straight tubule
def: "The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule[GO]." []
is_a: UBERON:0001290 ! proximal straight tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0001290 ! proximal straight tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron
relationship: part_of UBERON:0005151 ! metanephric proximal tubule
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0005127
name: metanephric thick ascending limb
def: "At the macula densa, the thick ascending limb connects to the distal convoluted tubule[GO]." []
is_a: UBERON:0001291 ! thick ascending limb of loop of Henle
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0001291 ! thick ascending limb of loop of Henle
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005129
name: metanephric distal tubule
def: "The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule[GO]." []
is_a: UBERON:0004135 ! distal tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0004135 ! distal tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005130
name: metanephric loop of Henle
def: "The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros[GO]." []
is_a: UBERON:0001288 ! loop of Henle
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004136 ! intermediate tubule
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005133
name: metanephric glomerulus vasculature
def: "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO]." []
is_a: UBERON:0004190 ! renal glomerulus vasculature
intersection_of: UBERON:0004190 ! renal glomerulus vasculature
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004736 ! metanephric glomerulus

[Term]
id: UBERON:0005134
name: metanephric nephron epithelium
def: "The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO]." []
is_a: UBERON:0004211 ! nephron epithelium
is_a: UBERON:0005108 ! metanephric epithelium
intersection_of: UBERON:0004211 ! nephron epithelium
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005135
name: metanephric glomerular epithelium
def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO]." []
is_a: UBERON:0004188 ! glomerular epithelium
is_a: UBERON:0005134 ! metanephric nephron epithelium
intersection_of: UBERON:0004188 ! glomerular epithelium
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004736 ! metanephric glomerulus
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005136
name: metanephric glomerular endothelium
def: "The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO]." []
is_a: UBERON:0004189 ! glomerular endothelium
is_a: UBERON:0005135 ! metanephric glomerular epithelium
intersection_of: UBERON:0004189 ! glomerular endothelium
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004736 ! metanephric glomerulus
relationship: part_of UBERON:0005110 ! metanephric nephron
relationship: part_of UBERON:0005133 ! metanephric glomerulus vasculature

[Term]
id: UBERON:0005144
name: metanephric glomerular capillary
def: "This process pertains to the initial formation of a structure from unspecified parts[GO]." []
is_a: UBERON:0004212 ! glomerular capillary
intersection_of: UBERON:0004212 ! glomerular capillary
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0004736 ! metanephric glomerulus
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005145
name: metanephric comma-shaped body
def: "The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." []
is_a: UBERON:0004198 ! comma-shaped body
intersection_of: UBERON:0004198 ! comma-shaped body
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005146
name: metanephric nephron tubule
def: "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO]." []
is_a: UBERON:0001231 ! nephron tubule
is_a: UBERON:0005106 ! metanephric tubule
is_a: UBERON:0005134 ! metanephric nephron epithelium
intersection_of: UBERON:0001231 ! nephron tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005147
name: metanephric renal vesicle
def: "The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." []
synonym: "metanephric vesicle" EXACT []
is_a: UBERON:0004209 ! renal vesicle
is_a: UBERON:0005108 ! metanephric epithelium
intersection_of: UBERON:0004209 ! renal vesicle
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005148
name: metanephric S-shaped body
def: "The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." []
is_a: UBERON:0004199 ! S-shaped body
intersection_of: UBERON:0004199 ! S-shaped body
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005149
name: metanephric connecting tubule
def: "The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros[GO]." []
is_a: UBERON:0005097 ! renal connecting tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0005097 ! renal connecting tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron

[Term]
id: UBERON:0005151
name: metanephric proximal tubule
def: "The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology[GO]." []
is_a: UBERON:0004134 ! proximal tubule
is_a: UBERON:0005146 ! metanephric nephron tubule
intersection_of: UBERON:0004134 ! proximal tubule
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005110 ! metanephric nephron
relationship: part_of UBERON:0010533 ! metanephros cortex

[Term]
id: UBERON:0005153
name: epithelial bud
def: "A bud is a protrusion that forms from an epithelial sheet by localized folding." []
is_a: UBERON:0005157 ! epithelial fold

[Term]
id: UBERON:0005154
name: epithelial cord
def: "A cord of epithelial cells without a lumen and usually several cells thick." []
is_a: UBERON:0000486 ! multilaminar epithelium

[Term]
id: UBERON:0005155
name: open tracheal system
def: "An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." []
synonym: "invertebrate tracheal system" EXACT []
synonym: "open tracheal system" EXACT []
synonym: "tracheal system" BROAD []
is_a: UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0005156
name: reproductive structure
def: "Any anatomical structure that is part of the reproductive system." []
synonym: "reproductive system element" EXACT []
synonym: "reproductive system structure" EXACT []
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: part_of UBERON:0000990 ! reproductive system
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0005157
name: epithelial fold
def: "An epithelial sheet bent on a linear axis." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0005158
name: parenchyma of central nervous system
def: "The functional tissue of the central nervous system consisting of neurons and glial cells." []
synonym: "central nervous system parenchyma" EXACT []
synonym: "CNS parenchyma" EXACT []
synonym: "parenchyma of central nervous system" EXACT []
synonym: "parenchyma of CNS" EXACT []
is_a: UBERON:0000353 ! parenchyma
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0005162
name: multi cell part structure
def: "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." []
synonym: "cell part cluster" RELATED []
synonym: "multi-cell-component structure" EXACT []
synonym: "multi-cell-part structure" EXACT []
is_a: UBERON:0000477 ! anatomical cluster

[Term]
id: UBERON:0005164
name: ascending limb of loop of Henle
def: "The distal part of the loop of Henle that is impermeable to water and actively pumps sodium out of the filtrate to generate the hypertonic interstitium that drives countercurrent exchange; it consists of an initial very thin segment lined by simple squamous epithelium followed by a distal thick segment lined by simple cuboidal epithelium[MP]." []
synonym: "ascending limb" BROAD []
synonym: "ascending limb of Henle's loop" EXACT []
synonym: "distal straight tubule" RELATED []
synonym: "loop of Henle ascending limb" EXACT []
is_a: UBERON:0004135 ! distal tubule
relationship: part_of UBERON:0001288 ! loop of Henle

[Term]
id: UBERON:0005167
name: papillary duct
def: "The terminal portions of the medullary collecting ducts are the papillary ducts, which end at the renal papilla and empty into a minor calyx." []
synonym: "Bellini's duct" RELATED []
synonym: "duct of Bellini" RELATED []
synonym: "papillary duct" EXACT []
synonym: "papillary duct of kidney" EXACT []
synonym: "renal papillary duct" EXACT []
is_a: UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: UBERON:0005168
name: renal interlobular vein
def: "Any of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins" []
synonym: "interlobular vein" EXACT []
synonym: "interlobular veins of kidney" RELATED []
synonym: "set of interlobular veins of kidney" RELATED []
synonym: "venae interlobulares renis" EXACT []
synonym: "venae interlobulares renis" RELATED []
is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0005169
name: interstitial tissue
def: "connective tissue between the cellular elements of a structure." []
synonym: "interstitium" EXACT []
is_a: UBERON:0003891 ! stroma

[Term]
id: UBERON:0005171
name: hepatic duct
def: "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." []
is_a: UBERON:0002394 ! bile duct
relationship: part_of UBERON:0001173 ! biliary tree

[Term]
id: UBERON:0005172
name: abdomen element
def: "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." []
synonym: "abdomen organ" EXACT []
is_a: UBERON:0005173 ! abdominal segment element
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0005173
name: abdominal segment element
def: "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." []
synonym: "abdominal segment organ" EXACT []
is_a: UBERON:0005177 ! trunk region element
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0005174
name: dorsal region element
def: "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." []
synonym: "back organ" EXACT []
synonym: "dorsal region organ" EXACT []
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0005175
name: chest organ
def: "An organ that is part of a chest [Automatically generated definition]." []
is_a: UBERON:0005181 ! thoracic segment organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0005176
name: tooth enamel organ
def: "." []
synonym: "dental organ" EXACT []
synonym: "enamel organ" EXACT []
synonym: "odontogenic organ" RELATED []
synonym: "organum enameleum" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0005087 ! tooth placode
relationship: has_part UBERON:0001763 ! odontogenic papilla
relationship: has_part UBERON:0003843 ! dental epithelium
relationship: part_of UBERON:0001091 ! calcareous tooth

[Term]
id: UBERON:0005177
name: trunk region element
def: "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." []
synonym: "trunk organ" EXACT []
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0005178
name: thoracic cavity element
def: "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." []
synonym: "thoracic cavity organ" EXACT []
is_a: UBERON:0005181 ! thoracic segment organ
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0005179
name: pelvic region element
def: "An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis." []
synonym: "pelvic element" EXACT []
synonym: "pelvis organ" EXACT []
synonym: "pelvis region organ" EXACT []
is_a: UBERON:0005173 ! abdominal segment element
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0002355 ! pelvic region of trunk

[Term]
id: UBERON:0005181
name: thoracic segment organ
def: "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." []
synonym: "upper body organ" RELATED []
is_a: UBERON:0005177 ! trunk region element
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0005184
name: hair medulla
def: "Innermost layer of the hair shaft." []
synonym: "medulla of hair shaft" RELATED []
is_a: UBERON:0000958 ! medulla of organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0001037 ! strand of hair
relationship: part_of UBERON:0001037 ! strand of hair

[Term]
id: UBERON:0005185
name: renal medulla collecting duct
def: "The portion of the collecting duct that resides in the renal medulla" []
synonym: "kidney medulla collecting duct" EXACT []
synonym: "medullary collecting duct" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0013522 ! subdivision of tube
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: part_of UBERON:0000362 ! renal medulla
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: UBERON:0005194
name: thoracic vein
def: "A vein that is part of a thorax [Automatically generated definition]." []
is_a: UBERON:0001638 ! vein
is_a: UBERON:0003834 ! thoracic segment blood vessel
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0005196
name: spleen germinal center
def: "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." []
synonym: "germinal center of spleen" EXACT []
synonym: "spleen follicle center" EXACT []
synonym: "spleen GC" EXACT []
synonym: "splenic germinal center" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010754 ! germinal center
intersection_of: UBERON:0010754 ! germinal center
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0004042 ! spleen secondary B follicle

[Term]
id: UBERON:0005200
name: thoracic mammary gland
def: "A lactiferous gland that is located in the thoracic region/breast." []
synonym: "anterior mammary gland" RELATED []
synonym: "breast mammary gland" EXACT []
synonym: "lactiferous gland" BROAD []
synonym: "mammary gland" BROAD []
is_a: UBERON:0001911 ! mammary gland
is_a: UBERON:0005175 ! chest organ
intersection_of: UBERON:0001911 ! mammary gland
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000310 ! breast
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0005202
name: distal straight tubule macula densa
def: "A macula densa that is part of an ascending limb of loop of Henle [Automatically generated definition]." []
is_a: UBERON:0002335 ! macula densa
intersection_of: UBERON:0002335 ! macula densa
intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0006853 ! renal cortex tubule

[Term]
id: UBERON:0005203
name: trachea gland
def: "A gland that is part of a submucosa of trachea [Automatically generated definition]." []
synonym: "glandula trachealis" EXACT []
synonym: "tracheal gland" EXACT []
synonym: "tubular seromucous gland of trachea" RELATED []
is_a: UBERON:0002530 ! gland
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0002202 ! submucosa of trachea
relationship: part_of UBERON:0002202 ! submucosa of trachea

[Term]
id: UBERON:0005205
name: vagina stroma
def: "A stroma that is part of a vagina." []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0005206
name: choroid plexus stroma
def: "A stroma that is part of a choroid plexus [Automatically generated definition]." []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus

[Term]
id: UBERON:0005207
name: tonsil capsule
def: "A capsule that is part of a tonsil [Automatically generated definition]." []
is_a: UBERON:0003893 ! capsule
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0003893 ! capsule
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: UBERON:0005211
name: renal medulla interstitium
def: "tissue surrounding the loop of Henle in the renal medulla." []
synonym: "kidney medulla interstitium" EXACT []
synonym: "medullary interstitium" NARROW []
synonym: "medullary stroma" RELATED []
synonym: "renal medullary interstitial tissue" EXACT []
synonym: "renal medullary interstitium" EXACT []
is_a: UBERON:0005215 ! kidney interstitium
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0005215 ! kidney interstitium

[Term]
id: UBERON:0005212
name: Leydig cell region of testis
def: "The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.." []
synonym: "interstitium of testis" EXACT []
synonym: "interstitium of the testis" EXACT []
synonym: "testis - interstitial" EXACT []
synonym: "testis interstitial tissue" EXACT []
synonym: "testis interstitium" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005169 ! interstitial tissue
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0005213
name: outer renal medulla interstitium
def: "A portion of interstitial tissue that is part of a outer medulla of kidney [Automatically generated definition]." []
synonym: "kidney outer medulla interstitium" EXACT []
synonym: "outer medullary interstitium" EXACT []
is_a: UBERON:0005211 ! renal medulla interstitium
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0005211 ! renal medulla interstitium

[Term]
id: UBERON:0005214
name: inner renal medulla interstitium
def: "A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition]." []
synonym: "inner medullary interstitium" EXACT []
synonym: "kidney inner medulla interstitium" EXACT []
synonym: "papillary interstitium" RELATED []
is_a: UBERON:0005211 ! renal medulla interstitium
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0005211 ! renal medulla interstitium

[Term]
id: UBERON:0005215
name: kidney interstitium
def: "The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes." []
synonym: "interstitial tissue of kidney" EXACT []
synonym: "kidney interstitium group" RELATED []
synonym: "renal interstitial tissue" EXACT []
synonym: "renal interstitium" EXACT []
synonym: "renal stroma" EXACT []
synonym: "stroma of kidney" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0005169 ! interstitial tissue
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0005216
name: optic eminence surface ectoderm
def: "An external ectoderm that is part of a optic eminence [Automatically generated definition]." []
is_a: UBERON:0000076 ! external ectoderm
intersection_of: UBERON:0000076 ! external ectoderm
intersection_of: part_of UBERON:0004348 ! optic eminence
relationship: part_of UBERON:0004348 ! optic eminence
relationship: part_of UBERON:0005234 ! optic eminence ectoderm

[Term]
id: UBERON:0005225
name: upper leg epithelium
def: "An epithelium that is part of a hindlimb stylopod [Automatically generated definition]." []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0005226
name: pedal digit epithelium
def: "An epithelium that is part of a toe [Automatically generated definition]." []
synonym: "foot digit epithelium" NARROW []
synonym: "hind limb digit epithelium" EXACT []
synonym: "toe epithelium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: develops_from UBERON:0003248 ! epithelium of footplate
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0005227
name: manual digit epithelium
def: "An epithelium that is part of a finger [Automatically generated definition]." []
synonym: "finger epithelium" EXACT []
synonym: "fore limb digit epithelium" EXACT []
synonym: "hand digit epithelium" NARROW []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: develops_from UBERON:0010332 ! epithelium of handplate
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0005228
name: upper arm epithelium
def: "An epithelium that is part of a forelimb stylopod [Automatically generated definition]." []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0005233
name: medial-nasal process ectoderm
def: "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." []
is_a: UBERON:0000924 ! ectoderm
is_a: UBERON:0014702 ! frontonasal process epithelium
intersection_of: UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0004068 ! medial nasal prominence
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0004068 ! medial nasal prominence

[Term]
id: UBERON:0005234
name: optic eminence ectoderm
def: "An ectoderm that is part of a optic eminence [Automatically generated definition]." []
is_a: UBERON:0000924 ! ectoderm
intersection_of: UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0004348 ! optic eminence
relationship: part_of UBERON:0004348 ! optic eminence

[Term]
id: UBERON:0005243
name: interventricular septum endocardium
def: "An endocardium that is part of a interventricular septum [Automatically generated definition]." []
synonym: "endocardium of interventricular septum" EXACT []
synonym: "interventricular septum endocardial tissue" RELATED []
is_a: UBERON:0002165 ! endocardium
intersection_of: UBERON:0002165 ! endocardium
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: UBERON:0005248
name: bulbus cordis myocardium
def: "A myocardium that is part of a bulbus cordis [Automatically generated definition]." []
synonym: "bulbus cordis cardiac muscle" RELATED []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0002349 ! myocardium
intersection_of: UBERON:0002349 ! myocardium
intersection_of: part_of UBERON:0004706 ! bulbus cordis
relationship: part_of UBERON:0004706 ! bulbus cordis

[Term]
id: UBERON:0005249
name: metanephric renal pelvis
def: "A renal pelvis that is part of a metanephros." []
synonym: "metanephros pelvis" EXACT []
is_a: UBERON:0001224 ! renal pelvis
intersection_of: UBERON:0001224 ! renal pelvis
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0005250
name: stomatodeum gland
def: "A gland that is part of a stomodeum." []
synonym: "stomatodaeum gland" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000930 ! stomodeum
relationship: part_of UBERON:0000930 ! stomodeum

[Term]
id: UBERON:0005253
name: head mesenchyme
def: "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." []
synonym: "cephalic mesenchyme" EXACT []
synonym: "cranial mesenchyme" RELATED []
synonym: "desmocranium" RELATED []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme

[Term]
id: UBERON:0005254
name: upper leg mesenchyme
def: "Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition]." []
is_a: UBERON:0003860 ! hindlimb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0000376 ! hindlimb stylopod

[Term]
id: UBERON:0005255
name: pedal digit mesenchyme
def: "Mesenchyme that is part of a developing toe [Automatically generated definition]." []
synonym: "finger ray mesenchyme" RELATED []
synonym: "foot digit mesenchyme" NARROW []
synonym: "hind limb digit mesenchyme" EXACT []
synonym: "pedal digital ray mesenchyme" RELATED []
synonym: "toe mesenchyme" EXACT []
is_a: UBERON:0003860 ! hindlimb mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010702 ! digit mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001466 ! pedal digit
relationship: develops_from UBERON:0003328 ! mesenchyme of footplate
relationship: part_of UBERON:0001466 ! pedal digit

[Term]
id: UBERON:0005256
name: trunk mesenchyme
def: "Mesenchyme that is part of a developing trunk." []
synonym: "trunk and cervical mesenchyme" RELATED []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000922 ! embryo
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme

[Term]
id: UBERON:0005257
name: manual digit mesenchyme
def: "Mesenchyme that is part of a developing finger [Automatically generated definition]." []
synonym: "anterior limb digital ray mesenchyme" RELATED []
synonym: "finger mesenchyme" EXACT []
synonym: "finger ray mesenchyme" RELATED []
synonym: "fore limb digit mesenchyme" EXACT []
synonym: "hand digit mesenchyme" NARROW []
synonym: "manual digital ray mesenchyme" RELATED []
is_a: UBERON:0003859 ! forelimb mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010702 ! digit mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002389 ! manual digit
relationship: develops_from UBERON:0009523 ! mesenchyme of handplate
relationship: part_of UBERON:0002389 ! manual digit

[Term]
id: UBERON:0005258
name: upper arm mesenchyme
def: "Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition]." []
is_a: UBERON:0003859 ! forelimb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0005268
name: renal cortex artery
def: "An artery that supplies the renal cortex." []
synonym: "kidney cortex artery" EXACT []
synonym: "renal cortex arterial system" RELATED []
synonym: "renal cortex artery" EXACT []
is_a: UBERON:0001637 ! artery
is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0005269
name: renal cortex vein
def: "Artery that receives blood from the renal cortex[MP, modified]" []
synonym: "kidney cortex vein" RELATED []
synonym: "renal cortex venous system" RELATED []
is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0005270
name: renal cortex interstitium
def: "A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells." []
synonym: "cortical stroma" RELATED []
synonym: "kidney cortex interstitium" EXACT []
synonym: "renal cortical interstitial tissue" EXACT []
is_a: UBERON:0005215 ! kidney interstitium
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0005215 ! kidney interstitium

[Term]
id: UBERON:0005271
name: juxtamedullary cortex
def: "The part of the renal cortex nearest to the medulla." []
synonym: "inner cortex of kidney" EXACT []
synonym: "inner renal cortex" EXACT []
synonym: "juxtamedullary cortex of kidney" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0005272
name: peritubular capillary
def: "the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" []
is_a: UBERON:0003527 ! kidney capillary

[Term]
id: UBERON:0005281
name: ventricular system of central nervous system
def: "A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP]." []
synonym: "CNS ventricular system" EXACT []
synonym: "ventricle system" RELATED []
synonym: "ventricular system" EXACT []
synonym: "ventricular system of neuraxis" EXACT []
synonym: "ventriculi cerebri" RELATED []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0005282
name: ventricular system of brain
synonym: "brain ventricular system" EXACT []
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0005281 ! ventricular system of central nervous system

[Term]
id: UBERON:0005283
name: tela choroidea
def: "A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm]." []
synonym: "tela chorioidea" RELATED []
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0005358 ! ventricle of nervous system

[Term]
id: UBERON:0005287
name: tela choroidea of fourth ventricle
def: "Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP]." []
synonym: "choroid membrane" EXACT []
synonym: "choroid membrane of fourth ventricle" EXACT []
synonym: "tela chorioidea fourth ventricle" EXACT []
synonym: "tela choroidea" BROAD []
synonym: "tela choroidea fourth ventricle" EXACT []
synonym: "tela choroidea of fourth ventricle" EXACT []
synonym: "tela choroidea ventriculi quarti" EXACT []
synonym: "tela choroidea ventriculi quarti" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005283 ! tela choroidea
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0005283 ! tela choroidea
intersection_of: part_of UBERON:0002422 ! fourth ventricle
relationship: part_of UBERON:0002422 ! fourth ventricle

[Term]
id: UBERON:0005289
name: tela choroidea of telencephalic ventricle
def: "Tela chorioidea that lines the telencephalic ventricle." []
synonym: "tela chorioidea of lateral ventricle" EXACT []
synonym: "tela chorioidea of telencephalic ventricle" EXACT []
synonym: "tela chorioidea telencephalic ventricle" EXACT []
synonym: "tela choroidea (ventriculi lateralis)" EXACT []
synonym: "tela choroidea of lateral ventricle" EXACT []
synonym: "tela choroidea telencephalic ventricle" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005283 ! tela choroidea
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0005283 ! tela choroidea
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle

[Term]
id: UBERON:0005290
name: myelencephalon
def: "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." []
synonym: "myelencephalon (medulla oblongata)" RELATED []
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0005291
name: embryonic tissue
def: "A portion of tissue that is part of an embryo." []
synonym: "developing tissue" RELATED []
synonym: "portion of embryonic tissue" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0002050 ! embryonic structure
intersection_of: UBERON:0000479 ! tissue
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0002050 ! embryonic structure

[Term]
id: UBERON:0005292
name: extraembryonic tissue
def: "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." []
synonym: "extra-embryonic tissue" EXACT []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: part_of UBERON:0016887 ! entire extraembryonic component
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0005294
name: gonadal ridge
def: "the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" []
synonym: "crista gonadalis" RELATED []
synonym: "genital cord" RELATED []
synonym: "genital ridge" EXACT []
synonym: "gonadal ridge" EXACT []
synonym: "indifferent gonadal ridge" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004876 ! urogenital fold
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004122 ! genitourinary system

[Term]
id: UBERON:0005295
name: sex cord
def: "Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female." []
synonym: "genital cord" RELATED []
synonym: "gonad cord" RELATED []
synonym: "gonadal cord" RELATED []
synonym: "primitive sex cord" RELATED []
is_a: UBERON:0005154 ! epithelial cord
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0005294 ! gonadal ridge
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0005296
name: ovary sex cord
def: "structures that develop from sex cords in the female. After further development they become the ovarian follicles." []
synonym: "cortical cord" RELATED []
synonym: "cortical sex cord" RELATED []
synonym: "ovary primitive sex cord" RELATED []
synonym: "ovigerous cord" EXACT []
synonym: "ovigerous cords" EXACT []
synonym: "secondary cord" RELATED []
is_a: UBERON:0004911 ! epithelium of female gonad
is_a: UBERON:0005295 ! sex cord
intersection_of: UBERON:0005295 ! sex cord
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: develops_from UBERON:0010141 ! primitive sex cord of indifferent gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0005297
name: testis sex cord
def: "The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP]." []
synonym: "primary sex cord" RELATED []
synonym: "testis cord" EXACT []
synonym: "testis primary sex cords" EXACT []
synonym: "testis primitive sex cord" RELATED []
is_a: UBERON:0004910 ! epithelium of male gonad
is_a: UBERON:0005295 ! sex cord
intersection_of: UBERON:0005295 ! sex cord
intersection_of: part_of UBERON:0000473 ! testis
relationship: part_of UBERON:0000473 ! testis

[Term]
id: UBERON:0005309
name: pronephric nephron
def: "A pronephric nephron is the functional unit of the pronephros[GO]." []
is_a: UBERON:0001285 ! nephron
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001285 ! nephron
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros

[Term]
id: UBERON:0005310
name: pronephric nephron tubule
def: "The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO]." []
synonym: "ciliated neck segment" RELATED []
synonym: "pronephric tubule" EXACT []
is_a: UBERON:0001231 ! nephron tubule
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0001231 ! nephron tubule
intersection_of: part_of UBERON:0005309 ! pronephric nephron
relationship: part_of UBERON:0005309 ! pronephric nephron

[Term]
id: UBERON:0005316
name: endocardial endothelium
def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." []
synonym: "endocardium endothelium" EXACT []
synonym: "endothelium of endocardium" EXACT []
is_a: UBERON:0004638 ! blood vessel endothelium
is_a: UBERON:0008307 ! heart endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0002165 ! endocardium
relationship: part_of UBERON:0002165 ! endocardium

[Term]
id: UBERON:0005317
name: pulmonary artery endothelium
def: "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." []
synonym: "pulmonary artery endothelial tube" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001917 ! endothelium of artery
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery

[Term]
id: UBERON:0005319
name: mesonephric collecting duct
def: "The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO]." []
is_a: UBERON:0001232 ! collecting duct of renal tubule
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001232 ! collecting duct of renal tubule
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron

[Term]
id: UBERON:0005320
name: mesonephric juxtaglomerular apparatus
def: "The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]." []
is_a: UBERON:0002303 ! juxtaglomerular apparatus
intersection_of: UBERON:0002303 ! juxtaglomerular apparatus
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005321
name: mesonephric smooth muscle tissue
def: "." []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005322
name: mesonephric nephron
def: "A nephron that is part of a mesonephros." []
synonym: "nephron of mesonephros" EXACT []
synonym: "stage IV nephron" RELATED []
is_a: UBERON:0001285 ! nephron
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001285 ! nephron
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: develops_from UBERON:0005323 ! mesonephric mesenchyme
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005323
name: mesonephric mesenchyme
def: "Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO]." []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005324
name: mesonephric macula densa
def: "The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus[GO]." []
is_a: UBERON:0002335 ! macula densa
is_a: UBERON:0005330 ! mesonephric nephron epithelium
intersection_of: UBERON:0002335 ! macula densa
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005320 ! mesonephric juxtaglomerular apparatus

[Term]
id: UBERON:0005325
name: mesonephric glomerulus
def: "The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO]." []
synonym: "glomerulus" BROAD []
is_a: UBERON:0000074 ! renal glomerulus
intersection_of: UBERON:0000074 ! renal glomerulus
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005326
name: mesonephric glomerulus vasculature
def: "The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO]." []
is_a: UBERON:0004190 ! renal glomerulus vasculature
intersection_of: UBERON:0004190 ! renal glomerulus vasculature
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005325 ! mesonephric glomerulus

[Term]
id: UBERON:0005327
name: mesonephric glomerular epithelium
def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO]." []
is_a: UBERON:0004188 ! glomerular epithelium
is_a: UBERON:0005330 ! mesonephric nephron epithelium
intersection_of: UBERON:0004188 ! glomerular epithelium
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron
relationship: part_of UBERON:0005325 ! mesonephric glomerulus

[Term]
id: UBERON:0005328
name: mesonephric comma-shaped body
def: "The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." []
is_a: UBERON:0004198 ! comma-shaped body
intersection_of: UBERON:0004198 ! comma-shaped body
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005329
name: mesonephric nephron tubule
def: "A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros[GO]." []
synonym: "mesonephric renal tubule" EXACT []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0001231 ! nephron tubule
is_a: UBERON:0005330 ! mesonephric nephron epithelium
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005330
name: mesonephric nephron epithelium
def: "The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO]." []
is_a: UBERON:0004211 ! nephron epithelium
is_a: UBERON:0005103 ! mesonephric epithelium
intersection_of: UBERON:0004211 ! nephron epithelium
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron

[Term]
id: UBERON:0005331
name: mesonephric renal vesicle
def: "The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." []
synonym: "mesonephric vesicle" EXACT []
is_a: UBERON:0004209 ! renal vesicle
is_a: UBERON:0005103 ! mesonephric epithelium
intersection_of: UBERON:0004209 ! renal vesicle
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: develops_from UBERON:0010534 ! primitive mesonephric nephron
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005332
name: mesonephric S-shaped body
def: "The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." []
is_a: UBERON:0004199 ! S-shaped body
intersection_of: UBERON:0004199 ! S-shaped body
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0005333
name: mammary bud
def: "A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland." []
synonym: "lactiferous gland bud" EXACT []
synonym: "mammary gland bud" EXACT []
synonym: "mammary primordium" RELATED []
synonym: "milk bud" RELATED []
is_a: UBERON:0005153 ! epithelial bud
is_a: UBERON:0010371 ! ecto-epithelium

[Term]
id: UBERON:0005334
name: oral lamina propria
def: "A lamina propria that is part of a mucosa of oral region." []
synonym: "lamina propria of oral mucosa" EXACT []
is_a: UBERON:0000030 ! lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0003343 ! mucosa of oral region
relationship: part_of UBERON:0003343 ! mucosa of oral region

[Term]
id: UBERON:0005337
name: outflow tract of ventricle
def: "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." []
synonym: "heart ventricle outflow tract" EXACT []
synonym: "outflow part of ventricle" EXACT []
synonym: "ventricular outflow tract" EXACT []
is_a: UBERON:0004145 ! outflow tract
intersection_of: UBERON:0004145 ! outflow tract
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle

[Term]
id: UBERON:0005338
name: outflow tract aortic component
def: "An outflow tract that is part of a aorta." []
is_a: UBERON:0004145 ! outflow tract
intersection_of: UBERON:0004145 ! outflow tract
intersection_of: part_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0005339
name: outflow tract pulmonary component
is_a: UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0005358
name: ventricle of nervous system
def: "A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord." []
synonym: "region of wall of ventricular system of neuraxis" RELATED []
synonym: "ventricular layer" EXACT []
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0005366
name: olfactory lobe
def: "The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions." []
is_a: UBERON:0016526 ! lobe of cerebral hemisphere
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0005375
name: spinal cord ventral column
def: "the area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure" []
synonym: "anterior column" EXACT []
synonym: "spinal cord anterior column" EXACT []
synonym: "ventral column" EXACT []
is_a: UBERON:0016550 ! spinal cord column
relationship: part_of UBERON:0002180 ! ventral funiculus of spinal cord

[Term]
id: UBERON:0005376
name: olfactory bulb external plexiform layer
def: "Cytoarchitectural part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer. The EPL is mostly neuropil composed almost entirely of mitral and tulfted cell dendrites and granule cell dendrites and their synaptic inputs." []
synonym: "EPL" RELATED []
synonym: "external plexiform layer" BROAD []
synonym: "external plexiform layer of the olfactory bulb" RELATED []
synonym: "OB outer plexiform layer" RELATED []
synonym: "olfactory bulb main external plexiform layer" EXACT []
is_a: UBERON:0009950 ! olfactory bulb plexiform layer

[Term]
id: UBERON:0005377
name: olfactory bulb glomerular layer
def: "The glomerular layer is the most superficial layer, consisting of mitral cell dendritic arborizations (glomeruli), olfactory nerve fibers, and periglomerular cells. Periglomerular cells contact multiple mitral cell dendrites within the glomeruli and provide lateral inhibition of neighboring glomeruli while allowing excitation of a specific mitral cell dendritic tree. Each mitral cell is contacted by at least 1000 olfactory nerve fibers[BTO]. Portion of tissue which is located in between the primary olfactory fiber layer and the external cellular layer of the olfactory bulb[ZFA]." []
synonym: "glomerular layer" BROAD []
synonym: "glomerular layer of the olfactory bulb" RELATED []
synonym: "olfactory bulb main glomerulus" EXACT []
synonym: "stratum glomerulosum bulbi olfactorii" EXACT []
is_a: UBERON:0004001 ! olfactory bulb layer

[Term]
id: UBERON:0005384
name: nasal cavity epithelium
def: "An epithelium that lines the nasal cavity." []
synonym: "nasal epithelium" EXACT []
synonym: "nasal mucosa" RELATED []
is_a: UBERON:0003350 ! epithelium of mucosa
is_a: UBERON:0004814 ! upper respiratory tract epithelium
is_a: UBERON:0019306 ! nose epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0001826 ! nasal cavity mucosa

[Term]
id: UBERON:0005385
name: nasal cavity respiratory epithelium
def: "An epithelium that is part of the respiratory segment of the nasal mucosa [Automatically generated definition]." []
is_a: UBERON:0005384 ! nasal cavity epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0015786 ! respiratory segment of nasal mucosa
relationship: part_of UBERON:0015786 ! respiratory segment of nasal mucosa

[Term]
id: UBERON:0005386
name: olfactory segment of nasal mucosa
def: "That portion of the nasal mucosa containing the sensory endings for olfaction; the organ of smell[MESH]." []
synonym: "olfactory area of nasal mucosa" EXACT []
synonym: "olfactory mucosa" EXACT []
synonym: "olfactory part of nasal mucosa" EXACT []
synonym: "olfactory zone of nasal mucosa" EXACT []
synonym: "pars olfactoria tunicae mucosae nasi" EXACT []
synonym: "pars olfactoria tunicae mucosae nasi" RELATED []
is_a: UBERON:0001826 ! nasal cavity mucosa
intersection_of: UBERON:0001826 ! nasal cavity mucosa
intersection_of: has_part UBERON:0001997 ! olfactory epithelium
intersection_of: part_of UBERON:0005725 ! olfactory system
disjoint_from: UBERON:0015786 ! respiratory segment of nasal mucosa
relationship: has_part UBERON:0001997 ! olfactory epithelium
relationship: part_of UBERON:0005725 ! olfactory system

[Term]
id: UBERON:0005388
name: photoreceptor array
def: "An array of photoreceptors and any supporting cells found in an eye." []
synonym: "light-sensitive tissue" EXACT []
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0005389
name: transparent eye structure
def: "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." []
synonym: "lens" NARROW []
is_a: UBERON:0000061 ! anatomical structure
relationship: part_of UBERON:0000970 ! eye

[Term]
id: UBERON:0005396
name: carotid artery segment
def: "One of: the common carotid artery, or its branches, the external and internal carotid arteries." []
synonym: "carotid" EXACT []
synonym: "carotid artery" EXACT []
synonym: "common carotid arterial subdivision" RELATED []
synonym: "subdivision of common carotid artery" EXACT []
is_a: UBERON:0004573 ! systemic artery

[Term]
id: UBERON:0005398
name: female reproductive gland
def: "A sex gland that is part of a female reproductive system." []
is_a: UBERON:0003937 ! sex gland
intersection_of: UBERON:0003937 ! sex gland
intersection_of: part_of UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0003134 ! female reproductive organ

[Term]
id: UBERON:0005399
name: male reproductive gland
def: "A sex gland that is part of a male reproductive system." []
synonym: "accessory sex gland" RELATED []
is_a: UBERON:0003937 ! sex gland
intersection_of: UBERON:0003937 ! sex gland
intersection_of: part_of UBERON:0000079 ! male reproductive system
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0005401
name: cerebral hemisphere gray matter
def: "A gray matter that is part of a cerebral hemisphere." []
synonym: "cerebral gray matter" EXACT []
synonym: "cerebral grey matter" EXACT []
synonym: "cerebral hemisphere grey matter" EXACT []
is_a: UBERON:0011300 ! gray matter of telencephalon
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0001869 ! cerebral hemisphere
relationship: part_of UBERON:0001869 ! cerebral hemisphere

[Term]
id: UBERON:0005406
name: perirenal fat
def: "The adipose capsule of kidney (or perinephric fat or perirenal fat) is a structure between the renal fascia and renal capsule, and may be regarded as a part of the latter. A different structure, the pararenal fat, is the adipose tissue superficial to the renal fascia." []
synonym: "adipose capsule of kidney" RELATED []
synonym: "capsula adiposa renis" RELATED []
synonym: "fatty capsule of kidney" RELATED []
synonym: "perinephric fat" RELATED []
synonym: "periphrenic fascia" RELATED []
synonym: "perirenal fascia" EXACT []
synonym: "perirenal fascia" RELATED []
synonym: "perirenal fat capsule" RELATED []
synonym: "perirenal fat pad" RELATED []
is_a: UBERON:0001013 ! adipose tissue

[Term]
id: UBERON:0005408
name: circumventricular organ
def: "Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow." []
synonym: "circumventricular organ" EXACT []
synonym: "circumventricular organ of neuraxis" EXACT []
synonym: "CVO" EXACT []
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0005409
name: alimentary part of gastrointestinal system
def: "The part of the digestive system that excludes the hepatobiliary system." []
synonym: "alimentary system" RELATED []
synonym: "alimentary tract" RELATED []
synonym: "gastro-intestinal system" RELATED []
synonym: "gastrointestinal (GI) tract" RELATED []
synonym: "gastrointestinal system" RELATED []
synonym: "gastrointestinal tract" RELATED []
synonym: "GI tract" RELATED []
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0005417
name: forelimb bud
def: "A limb bud that develops into a forelimb." []
synonym: "anterior limb bud" EXACT []
synonym: "arm bud" RELATED []
synonym: "limb bud - forelimb" EXACT []
synonym: "upper limb bud" EXACT []
synonym: "wing bud" NARROW []
is_a: UBERON:0004347 ! limb bud
is_a: UBERON:0005419 ! pectoral appendage bud
disjoint_from: UBERON:0005418 ! hindlimb bud
relationship: part_of UBERON:0000153 ! anterior region of body

[Term]
id: UBERON:0005418
name: hindlimb bud
def: "A limb bud that develops into a hindlimb." []
synonym: "hind limb bud" EXACT []
synonym: "leg bud" RELATED []
synonym: "limb bud - hindlimb" RELATED []
synonym: "posterior limb bud" EXACT []
is_a: UBERON:0004347 ! limb bud
is_a: UBERON:0005420 ! pelvic appendage bud
relationship: part_of UBERON:0000154 ! posterior region of body

[Term]
id: UBERON:0005419
name: pectoral appendage bud
def: "A limb bud that develops into a forelimb or pectoral fin." []
synonym: "forelimb - pectoral fin bud" EXACT []
synonym: "pectoral fin bud" RELATED []
synonym: "pectoral fin buds" RELATED []
is_a: UBERON:0004357 ! paired limb/fin bud
relationship: part_of UBERON:0000153 ! anterior region of body

[Term]
id: UBERON:0005420
name: pelvic appendage bud
def: "A limb bud that develops into a hindlimb or pelvic fin." []
synonym: "hindlimb/pelvic fin bud" EXACT []
synonym: "pelvic fin bud" RELATED []
synonym: "pelvic fin buds" RELATED []
is_a: UBERON:0004357 ! paired limb/fin bud
relationship: part_of UBERON:0000154 ! posterior region of body

[Term]
id: UBERON:0005421
name: pectoral appendage apical ectodermal ridge
def: "An apical ectodermal ridge that is part of a pectoral appendage bud." []
synonym: "AER forelimb" NARROW []
synonym: "aer pectoral fin" RELATED []
synonym: "apical ectodermal ridge forelimb" NARROW []
synonym: "apical ectodermal ridge pectoral fin" RELATED []
synonym: "apical ectodermal ridge pectoral fin bud" NARROW []
synonym: "apical fold pectoral fin" RELATED []
synonym: "upper limb bud apical ectodermal ridge" NARROW []
synonym: "wing AER" NARROW []
synonym: "wing apical ectodermal ridge" NARROW []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004356 ! apical ectodermal ridge
intersection_of: UBERON:0004356 ! apical ectodermal ridge
intersection_of: part_of UBERON:0005419 ! pectoral appendage bud
relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm
relationship: part_of UBERON:0005419 ! pectoral appendage bud

[Term]
id: UBERON:0005422
name: pelvic appendage apical ectodermal ridge
def: "An apical ectodermal ridge that is part of a pelvic appendage bud." []
synonym: "AER hindlimb" RELATED []
synonym: "apical ectodermal ridge hind limb" NARROW []
synonym: "apical ectodermal ridge hindlimb" NARROW []
synonym: "apical ectodermal ridge pelvic fin bud" RELATED []
synonym: "leg AER" RELATED []
synonym: "lower lmb bud apical ectodermal ridge" NARROW []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004356 ! apical ectodermal ridge
intersection_of: UBERON:0004356 ! apical ectodermal ridge
intersection_of: part_of UBERON:0005420 ! pelvic appendage bud
relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm
relationship: part_of UBERON:0005420 ! pelvic appendage bud

[Term]
id: UBERON:0005423
name: developing anatomical structure
synonym: "developing structure" RELATED []
synonym: "developmental structure" RELATED []
synonym: "developmental tissue" RELATED []
is_a: UBERON:0000465 ! material anatomical entity

[Term]
id: UBERON:0005426
name: lens vesicle
def: "Portion of tissue that gives rise to the lens." []
synonym: "hollow lens vesicle" NARROW []
synonym: "immature lens" RELATED []
synonym: "lens mass" RELATED []
synonym: "presumptive lens" RELATED []
synonym: "solid lens vesicle" NARROW []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0003073 ! lens placode

[Term]
id: UBERON:0005427
name: corneal primordium
def: "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0010312 ! immature eye
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0005428
name: vagal neural crest
def: "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." []
synonym: "enteric neural crest" RELATED []
synonym: "post-otic neural crest" RELATED []
synonym: "VNC" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0002342 ! neural crest

[Term]
id: UBERON:0005432
name: aortic sac
def: "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" []
synonym: "saccus aorticus" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001637 ! artery
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003498 ! heart blood vessel
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: develops_from UBERON:0004363 ! pharyngeal arch artery
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004145 ! outflow tract

[Term]
id: UBERON:0005445
name: segment of pes
def: "A segment of autopod that is part of a pes." []
synonym: "foot region" BROAD []
synonym: "foot subdivision" EXACT []
synonym: "regio pedis" EXACT []
synonym: "segment of foot" EXACT []
synonym: "subdivision of foot" EXACT []
is_a: UBERON:0008784 ! lower limb segment
is_a: UBERON:0012139 ! segment of autopod
intersection_of: UBERON:0012139 ! segment of autopod
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0005451
name: segment of manus
def: "A segment of autopod that is part of a manus." []
synonym: "hand region" BROAD []
synonym: "hand subdivision" EXACT []
synonym: "regio manus" EXACT []
synonym: "segment of hand" EXACT []
synonym: "subdivision of hand" EXACT []
is_a: UBERON:0008785 ! upper limb segment
is_a: UBERON:0012139 ! segment of autopod
intersection_of: UBERON:0012139 ! segment of autopod
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0005477
name: stomach fundus epithelium
def: "A simple columnar epithelium that is part of a fundus of stomach." []
synonym: "epithelium of fundus of stomach" EXACT []
synonym: "gastric epithelium of fundus" EXACT []
synonym: "gastric fundus epithelium" EXACT []
is_a: UBERON:0001276 ! epithelium of stomach
intersection_of: UBERON:0000485 ! simple columnar epithelium
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach

[Term]
id: UBERON:0005483
name: thymus lobe
def: "Either of the two lateral lobes that constitute the thymus." []
synonym: "lateral lobe of thymus" EXACT []
synonym: "lobe of thymus" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0009912 ! anatomical lobe
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus

[Term]
id: UBERON:0005497
name: non-neural ectoderm
synonym: "epidermal ectoderm" NARROW []
synonym: "epithelial ectoderm" NARROW []
synonym: "non neural ectoderm" EXACT []
synonym: "surface ectoderm" RELATED []
synonym: "ventral ectoderm" RELATED []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0005498
name: primitive heart tube
def: "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." []
synonym: "early primitive heart tube" NARROW []
synonym: "primitive heart tube" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004291 ! heart rudiment
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0005562
name: thymus primordium
def: "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." []
synonym: "thymic primordium" EXACT []
synonym: "thymic rudiment" EXACT []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0003351 ! pharyngeal epithelium
relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm
relationship: part_of UBERON:0002405 ! immune system
relationship: part_of UBERON:0003295 ! pharyngeal gland

[Term]
id: UBERON:0005564
name: gonad primordium
def: "Portion of tissue that gives rise to the immature gonad." []
synonym: "future gonad" EXACT []
synonym: "gonadal primordium" EXACT []
synonym: "immature gonad" RELATED []
synonym: "primitive gonad" EXACT []
synonym: "undifferentiated gonad" EXACT []
is_a: UBERON:0001048 ! primordium
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0005565
name: facio-acoustic neural crest
def: "Cranial neural crest that gives rise to the facio-acoustic ganglion." []
synonym: "facio acoustic neural crest" EXACT []
is_a: UBERON:0003099 ! cranial neural crest
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
is_a: UBERON:0007530 ! migrating mesenchyme population
relationship: develops_from UBERON:0003849 ! mesencephalic neural crest

[Term]
id: UBERON:0005594
name: head somite
def: "Somite located in the head region, caudal to the otic vesicle" []
synonym: "cranial somite" RELATED []
synonym: "occipital somite" EXACT []
is_a: UBERON:0002329 ! somite
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0002329 ! somite
intersection_of: develops_from UBERON:0009617 ! head paraxial mesoderm
relationship: develops_from UBERON:0009617 ! head paraxial mesoderm
relationship: part_of UBERON:0009617 ! head paraxial mesoderm

[Term]
id: UBERON:0005597
name: lung primordium
def: "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." []
synonym: "lateral diverticula" RELATED []
synonym: "lung diverticulum" RELATED []
synonym: "lung endoderm" RELATED []
is_a: UBERON:0001048 ! primordium
relationship: develops_from UBERON:0001041 ! foregut
relationship: part_of UBERON:0008947 ! respiratory primordium

[Term]
id: UBERON:0005598
name: trunk somite
def: "A somite that is part of a trunk." []
is_a: UBERON:0002329 ! somite
intersection_of: UBERON:0002329 ! somite
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0005602
name: dorsal mesogastrium
def: "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." []
synonym: "dorsal mesentery" RELATED []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003281 ! mesentery of stomach
relationship: part_of UBERON:0002296 ! dorsal mesentery
relationship: part_of UBERON:0003281 ! mesentery of stomach

[Term]
id: UBERON:0005604
name: extrahepatic part of hepatic duct
synonym: "extrahepatic part of the hepatic duct" EXACT []
synonym: "hepatic duct extrahepatic part" EXACT []
is_a: UBERON:0002394 ! bile duct
relationship: part_of UBERON:0003703 ! extrahepatic bile duct
relationship: part_of UBERON:0005171 ! hepatic duct

[Term]
id: UBERON:0005613
name: left dorsal aorta
is_a: UBERON:0000947 ! aorta
is_a: UBERON:0003513 ! trunk blood vessel
relationship: part_of UBERON:0005805 ! dorsal aorta

[Term]
id: UBERON:0005622
name: right dorsal aorta
is_a: UBERON:0000947 ! aorta
is_a: UBERON:0003513 ! trunk blood vessel
relationship: part_of UBERON:0005805 ! dorsal aorta

[Term]
id: UBERON:0005629
name: vascular plexus
def: "A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part." []
synonym: "plexus vasculosus" EXACT []
is_a: UBERON:0002049 ! vasculature
relationship: has_part UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001009 ! circulatory system

[Term]
id: UBERON:0005631
name: extraembryonic membrane
def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." []
is_a: UBERON:0000158 ! membranous layer
is_a: UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0004716 ! conceptus
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0005636
name: caecum epithelium
def: "An epithelium that is part of a caecum." []
is_a: UBERON:0000397 ! colonic epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0005637
name: pyloric region epithelium
def: "An epithelium that is part of a pylorus." []
is_a: UBERON:0001276 ! epithelium of stomach
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0005638
name: anterior chamber epithelium
def: "An epithelium that is part of a anterior chamber of eyeball." []
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 ! anterior chamber of eyeball

[Term]
id: UBERON:0005641
name: otocyst epithelium
def: "An epithelium that is part of a ear vesicle." []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0003051 ! ear vesicle

[Term]
id: UBERON:0005656
name: lens vesicle epithelium
def: "An epithelium that is part of a lens vesicle." []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0005426 ! lens vesicle
relationship: part_of UBERON:0005426 ! lens vesicle

[Term]
id: UBERON:0005660
name: 2nd arch ectoderm
def: "An ectoderm that is part of a pharyngeal arch 2." []
synonym: "2nd pharyngeal arch ectoderm" EXACT []
is_a: UBERON:0000924 ! ectoderm
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0003066 ! pharyngeal arch 2

[Term]
id: UBERON:0005664
name: 2nd arch endoderm
def: "An endoderm that is part of a pharyngeal arch 2." []
synonym: "2nd pharyngeal arch endoderm" EXACT []
is_a: UBERON:0000925 ! endoderm
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0003066 ! pharyngeal arch 2

[Term]
id: UBERON:0005667
name: connecting stalk mesoderm
is_a: UBERON:0003422 ! mesenchyme of umbilical cord
is_a: UBERON:0007524 ! dense mesenchyme tissue
relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm
relationship: part_of UBERON:0002331 ! umbilical cord

[Term]
id: UBERON:0005672
name: right lung endothelium
def: "An endothelium that is part of a right lung." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0003364 ! epithelium of right lung
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0005673
name: left lung endothelium
def: "An endothelium that is part of a left lung." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0003365 ! epithelium of left lung
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0005677
name: caecum mesentery
def: "A mesentery that is part of a caecum." []
is_a: UBERON:0003396 ! mesentery of colon
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0005685
name: midgut dorsal mesentery
def: "A dorsal mesentery that is part of a midgut." []
is_a: UBERON:0002296 ! dorsal mesentery
intersection_of: UBERON:0002296 ! dorsal mesentery
intersection_of: part_of UBERON:0001045 ! midgut
relationship: part_of UBERON:0001045 ! midgut

[Term]
id: UBERON:0005686
name: caecum dorsal mesentery
def: "A dorsal mesentery that is part of a caecum." []
is_a: UBERON:0002296 ! dorsal mesentery
intersection_of: UBERON:0002296 ! dorsal mesentery
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0005689
name: 2nd arch mesenchyme
def: "Mesenchyme that is part of a pharyngeal arch 2." []
synonym: "2nd branchial arch mesenchyme" RELATED []
synonym: "2nd pharyngeal arch mesenchyme" EXACT []
synonym: "pharyngeal arch 2 mesenchyme" RELATED []
is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0003066 ! pharyngeal arch 2

[Term]
id: UBERON:0005702
name: optic eminence mesenchyme
def: "Mesenchyme that is part of a optic eminence." []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004348 ! optic eminence
relationship: part_of UBERON:0004348 ! optic eminence

[Term]
id: UBERON:0005711
name: foregut duodenum mesentery
def: "A mesentery of duodenum that is part of a foregut." []
is_a: UBERON:0003397 ! mesentery of duodenum
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003397 ! mesentery of duodenum
intersection_of: part_of UBERON:0001041 ! foregut
relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm
relationship: part_of UBERON:0001041 ! foregut

[Term]
id: UBERON:0005712
name: midgut duodenum mesentery
def: "A mesentery of duodenum that is part of a midgut." []
is_a: UBERON:0003284 ! mesentery of midgut
is_a: UBERON:0003397 ! mesentery of duodenum
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0003397 ! mesentery of duodenum
intersection_of: part_of UBERON:0001045 ! midgut
relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm
relationship: part_of UBERON:0001045 ! midgut

[Term]
id: UBERON:0005719
name: footplate apical ectodermal ridge
def: "An apical ectodermal ridge that is part of a footplate." []
is_a: UBERON:0004356 ! apical ectodermal ridge
intersection_of: UBERON:0004356 ! apical ectodermal ridge
intersection_of: part_of UBERON:0006871 ! footplate
relationship: part_of UBERON:0003373 ! ectoderm of footplate
relationship: part_of UBERON:0006871 ! footplate

[Term]
id: UBERON:0005720
name: hindbrain venous system
def: "A venous system that is part of a hindbrain." []
synonym: "rhombencephalon venous system" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004582 ! venous system
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0004582 ! venous system
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0005721
name: pronephric mesoderm
def: "A mesoderm that has the potential to develop into a pronephros." []
synonym: "pronephric anlage" RELATED []
synonym: "pronephric bulge" RELATED []
synonym: "pronephric mesenchyme" RELATED []
synonym: "pronephric primordium" RELATED []
is_a: UBERON:0000926 ! mesoderm
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0003064 ! intermediate mesoderm

[Term]
id: UBERON:0005725
name: olfactory system
def: "A sensory system that is capable of olfacttion (the sensory perception of smell)." []
is_a: UBERON:0005726 ! chemosensory system

[Term]
id: UBERON:0005726
name: chemosensory system
is_a: UBERON:0001032 ! sensory system

[Term]
id: UBERON:0005728
name: extraembryonic mesoderm
def: "." []
synonym: "extra-embryonic mesoderm" EXACT []
synonym: "extraembryonic mesenchyme" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005292 ! extraembryonic tissue
is_a: UBERON:0007524 ! dense mesenchyme tissue
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: develops_from UBERON:0008780 ! inner cell mass derived epiblast
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0005729
name: pectoral appendage field
def: "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." []
synonym: "pectoral appendage field of lateral plate mesoderm" EXACT []
synonym: "pectoral fin field" NARROW []
is_a: UBERON:0005732 ! paired limb/fin field
is_a: UBERON:0006598 ! presumptive structure

[Term]
id: UBERON:0005730
name: pelvic appendage field
def: "A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme." []
synonym: "pelvic appendage field of lateral plate mesoderm" EXACT []
synonym: "pelvic fin field" NARROW []
is_a: UBERON:0005732 ! paired limb/fin field
is_a: UBERON:0006598 ! presumptive structure

[Term]
id: UBERON:0005732
name: paired limb/fin field
def: "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." []
synonym: "limb/fin field of lateral plate mesoderm" EXACT []
synonym: "paired limb/fin field" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007688 ! anlage
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0005734
name: tunica adventitia of blood vessel
def: "The outermost layer of a blood vessel, composed mainly of fibrous tissue." []
synonym: "adventitia externa" EXACT []
synonym: "external coat" RELATED []
synonym: "tunica adventitia" EXACT []
synonym: "tunica adventitia of vessel" EXACT []
synonym: "tunica adventitia vasorum" RELATED []
synonym: "tunica externa vasorum" RELATED []
is_a: UBERON:0004797 ! blood vessel layer
is_a: UBERON:0005742 ! adventitia

[Term]
id: UBERON:0005740
name: tunica intima of artery
def: "A tunica intima that is part of a artery." []
synonym: "arterial intima" EXACT []
synonym: "tunica interna (intima)(arteriae)" EXACT []
is_a: UBERON:0001917 ! endothelium of artery
is_a: UBERON:0002523 ! tunica intima
intersection_of: UBERON:0002523 ! tunica intima
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0000415 ! artery wall
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0005742
name: adventitia
def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." []
synonym: "tunica advetitia" NARROW []
synonym: "tunica externa" NARROW []
is_a: UBERON:0004923 ! organ component layer

[Term]
id: UBERON:0005744
name: bone foramen
def: "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." []
synonym: "foramen" BROAD []
synonym: "foramens@fr" EXACT []
synonym: "foramina@fr" EXACT []
is_a: UBERON:0004111 ! anatomical conduit
intersection_of: UBERON:0004111 ! anatomical conduit
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0005749
name: glomerular tuft
def: "The capillary loops of the kidney that normally function as a filtration unit[MP]." []
synonym: "glomerular capillary tuft" RELATED []
synonym: "glomerulus" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0001230 ! glomerular capsule

[Term]
id: UBERON:0005750
name: glomerular parietal epithelium
def: "A single layer of simple squamous epithelium in the glomerular capsule. Does not function in filtration[UBERON]. outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium[MP]" []
synonym: "Bowman's parietal epithelium" EXACT []
synonym: "capsular epithelium" EXACT []
synonym: "glomerular capsule parietal layer" EXACT []
synonym: "kidney parietal epithelium" RELATED []
synonym: "outer layer of glomerular capsule" EXACT []
synonym: "parietal capsular epithelium" EXACT []
synonym: "parietal epithelial layer" EXACT []
synonym: "parietal epithelium of Bowman's capsule" EXACT []
synonym: "parietal layer of Bowman capsule" EXACT []
synonym: "parietal layer of Bowman's capsule" EXACT []
synonym: "parietal layer of glomerular capsule" EXACT []
synonym: "renal glomerular capsule epithelium" EXACT []
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0004188 ! glomerular epithelium
relationship: part_of UBERON:0001230 ! glomerular capsule

[Term]
id: UBERON:0005751
name: visceral layer of glomerular capsule
def: "The inner, or visceral, layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer, or parietal, layer by the capsular (Bowman's) space[BTO]. Lies just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]" []
synonym: "Bowman's visceral epithelium" EXACT []
synonym: "glomerular capsule visceral layer" EXACT []
synonym: "inner epithelial layer of Bowman's capsule" EXACT []
synonym: "podocyte layer of Bowman's capsule" EXACT []
synonym: "visceral epithelium of Bowman's capsule" EXACT []
synonym: "visceral layer of Bowman's capsule" EXACT []
synonym: "visceral layer of glomerular capsule" EXACT []
is_a: UBERON:0004211 ! nephron epithelium
relationship: part_of UBERON:0001230 ! glomerular capsule

[Term]
id: UBERON:0005753
name: caudal part of nephrogenic cord
def: "The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm." []
synonym: "caudal portion of nephrogenic cord" EXACT []
synonym: "caudal region of nephrogenic cord" EXACT []
synonym: "rear part of nephrogenic cord" EXACT []
synonym: "rear portion of nephrogenic cord" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004875 ! nephrogenic cord

[Term]
id: UBERON:0005754
name: rostral part of nephrogenic cord
def: "The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros." []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004875 ! nephrogenic cord

[Term]
id: UBERON:0005760
name: urorectal septum
def: "The ridge of mesoderm covered with endoderm that in the early developing embryo partitions the endodermal cloaca into the primary urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally); the urorectal septum eventually fuses with the cloacal membrane, dividing it into a dorsal anal membrane and a larger ventral urogenital membrane - this area of fusion is represented in the adult by the perineal body[MP]." []
synonym: "cloacal septum" RELATED []
synonym: "septum urorectale" EXACT []
synonym: "urorectal fold" EXACT []
synonym: "urorectal membrane" EXACT []
is_a: UBERON:0003037 ! septum
relationship: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0012361 ! internal anal region

[Term]
id: UBERON:0005764
name: acellular membrane
def: "A acellular anatomical structure that is the bounding layer of a anatomical structure." []
is_a: UBERON:0000476 ! acellular anatomical structure

[Term]
id: UBERON:0005769
name: basement membrane of epithelium
def: "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." []
synonym: "basement membrane" RELATED []
synonym: "basement membrane of connective tissue" EXACT []
synonym: "membrana basalis" EXACT []
is_a: UBERON:0005764 ! acellular membrane
relationship: part_of UBERON:0000483 ! epithelium

[Term]
id: UBERON:0005777
name: glomerular basement membrane
def: "the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" []
synonym: "GBM" BROAD []
synonym: "glomerular capillary basement membrane" EXACT []
synonym: "glomerular filtration membrane" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005769 ! basement membrane of epithelium
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0004188 ! glomerular epithelium

[Term]
id: UBERON:0005792
name: nephric ridge
def: "Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions." []
synonym: "nephric cord" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0004122 ! genitourinary system

[Term]
id: UBERON:0005800
name: section of aorta
def: "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." []
synonym: "aortic section" EXACT []
synonym: "aortic segment" RELATED []
synonym: "portion of aorta" RELATED []
synonym: "segment of aorta" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013522 ! subdivision of tube
relationship: part_of UBERON:0000947 ! aorta

[Term]
id: UBERON:0005805
name: dorsal aorta
def: "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." []
synonym: "aorta dorsalis" EXACT []
synonym: "aortae dorsales" RELATED []
synonym: "DA" EXACT []
synonym: "dorsal aorta root" RELATED []
synonym: "dorsal aortae" RELATED []
synonym: "dorsal aortic root" RELATED []
synonym: "dorsal aortæ" RELATED []
is_a: UBERON:0000947 ! aorta
is_a: UBERON:0003513 ! trunk blood vessel
relationship: develops_from UBERON:0001917 ! endothelium of artery
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0002201 ! vasculature of trunk

[Term]
id: UBERON:0005806
name: portal system
def: "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." []
synonym: "portal venous system" EXACT []
is_a: UBERON:0002049 ! vasculature
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0005808
name: bone tissue of long bone
def: "A bone tissue that is part of a long bone." []
synonym: "osseous tissue of long bone" RELATED []
is_a: UBERON:0002481 ! bone tissue
intersection_of: UBERON:0002481 ! bone tissue
intersection_of: part_of UBERON:0002495 ! long bone
relationship: part_of UBERON:0002495 ! long bone

[Term]
id: UBERON:0005856
name: developing mesenchymal condensation
def: "A delimited region of dense mesenchyme within looser mesenchyme." []
synonym: "mesenchyme condensation" EXACT []
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0011585 ! cell condensation

[Term]
id: UBERON:0005863
name: cartilaginous condensation
def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." []
synonym: "cartilage condensation" EXACT []
synonym: "cartilagenous condensation" EXACT []
synonym: "chondrogenic condensation" EXACT []
is_a: UBERON:0005856 ! developing mesenchymal condensation
relationship: develops_from UBERON:0005866 ! pre-cartilage condensation
relationship: part_of UBERON:0004288 ! skeleton

[Term]
id: UBERON:0005865
name: pre-muscle condensation
synonym: "pre muscle mass" EXACT []
synonym: "premuscle mass" EXACT []
is_a: UBERON:0005856 ! developing mesenchymal condensation

[Term]
id: UBERON:0005866
name: pre-cartilage condensation
def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." []
synonym: "pre-chondrogenic condensation" EXACT []
synonym: "precartilage condensation" EXACT []
synonym: "precartilagenous condensation" EXACT []
synonym: "prechondrogenic condensation" EXACT []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0005856 ! developing mesenchymal condensation
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004288 ! skeleton

[Term]
id: UBERON:0005867
name: mandibular prominence
def: "the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip" []
synonym: "mandibular process" RELATED []
synonym: "mandibular swelling" RELATED []
synonym: "prominentia mandibularis" RELATED []
is_a: UBERON:0012314 ! embryonic facial prominence
relationship: develops_from UBERON:0007237 ! 1st arch mandibular component
relationship: part_of UBERON:0000166 ! oral opening

[Term]
id: UBERON:0005872
name: 1st arch pharyngeal cleft
def: "A groove that is situated between the 1st and 2nd pharyngeal arch." []
synonym: "1st arch branchial groove" EXACT []
synonym: "1st arch groove ectoderm" EXACT []
synonym: "1st branchial cleft" RELATED []
synonym: "1st pharyngeal cleft" RELATED []
synonym: "1st pharyngeal groove" EXACT []
synonym: "1st pharyngeal groove ectoderm" EXACT []
synonym: "branchial groove of 1st arch" EXACT []
is_a: UBERON:0005879 ! pharyngeal cleft

[Term]
id: UBERON:0005876
name: undifferentiated genital tubercle
def: "the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin" []
synonym: "genital tubercle" RELATED []
synonym: "phallic tubercle" RELATED []
synonym: "tuberculum genitale" RELATED []
synonym: "tuberculum phallicum" RELATED []
synonym: "undifferentiated genital tubercle" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004874 ! somatopleure
relationship: part_of UBERON:0009196 ! indifferent external genitalia

[Term]
id: UBERON:0005879
name: pharyngeal cleft
def: "An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches." []
synonym: "branchial cleft" RELATED []
synonym: "branchial groove" RELATED []
synonym: "gill cleft" NARROW []
synonym: "Kiemenspalten" RELATED []
synonym: "pharyngeal ectodermal cleft" RELATED []
synonym: "pharyngeal groove" BROAD []
synonym: "pharyngeal groove ectoderm" EXACT []
synonym: "pharyngeal slit" RELATED []
synonym: "sulcus pharyngei" RELATED []
is_a: UBERON:0006846 ! surface groove
is_a: UBERON:0016545 ! pharyngeal ectoderm
relationship: part_of UBERON:0000076 ! external ectoderm

[Term]
id: UBERON:0005881
name: autopodial extension
def: "A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis." []
synonym: "digit or predigit" RELATED []
synonym: "limb outgrowth" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0002470 ! autopod region

[Term]
id: UBERON:0005884
name: hyoid arch skeleton
def: "A subdivision of skeleton that supports pharyngeal arch 2." []
synonym: "hyal@fr" EXACT []
synonym: "hyocïde@fr" EXACT []
synonym: "hyoid arch" RELATED []
synonym: "hyoid arch skeleton" EXACT []
synonym: "hyoid bars" NARROW []
synonym: "pharyngeal arch 2 skeleton" EXACT []
synonym: "visceral arch 2" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: develops_from UBERON:0003066 ! pharyngeal arch 2
relationship: develops_from UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0008895 ! splanchnocranium

[Term]
id: UBERON:0005891
name: coelomic epithelium
def: "The epithelial lining of the surface of the coelom." []
synonym: "celomic epithelium" EXACT []
synonym: "germinal epithelium of Waldeyer" EXACT []
is_a: UBERON:0000483 ! epithelium
relationship: part_of UBERON:0011997 ! coelom

[Term]
id: UBERON:0005893
name: leg bone
def: "A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx" []
is_a: UBERON:0003464 ! hindlimb bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0000978 ! leg
relationship: part_of UBERON:0000978 ! leg

[Term]
id: UBERON:0005897
name: manus bone
def: "A bone that is part of the manus skeleton. Note that this includes the carpal bones." []
synonym: "bone of hand" EXACT []
synonym: "bone of hand skeleton" EXACT []
synonym: "bone of manus" EXACT []
synonym: "bone of pectoral limb autopod" EXACT []
synonym: "bone of pectoral limb autopodium" EXACT []
synonym: "forelimb autopod bone" EXACT []
synonym: "forelimb autopodium bone" EXACT []
synonym: "hand bone" EXACT []
is_a: UBERON:0008962 ! forelimb bone
is_a: UBERON:0011250 ! autopod bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0001442 ! skeleton of manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0005899
name: pes bone
def: "A bone that is part of the pes skeleton" []
synonym: "bone of foor proper or tarsal skeleton" EXACT []
synonym: "bone of foot" EXACT []
synonym: "bone of pedal skeleton" EXACT []
synonym: "bone of pes" EXACT []
synonym: "foot bone" EXACT []
is_a: UBERON:0003464 ! hindlimb bone
is_a: UBERON:0011250 ! autopod bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0001445 ! skeleton of pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0005903
name: duct of seminal vesicle
def: "Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP]." []
synonym: "ductus excretorius (vesicula seminalis)" EXACT []
synonym: "ductus excretorius glandulae vesiculosae" EXACT []
synonym: "ductus excretorius glandulae vesiculosae" RELATED []
synonym: "excretory duct of seminal gland" EXACT []
synonym: "seminal vesicle duct" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005904 ! duct of male reproductive system
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle

[Term]
id: UBERON:0005904
name: duct of male reproductive system
def: "Any of the ducts that are part of a male reproductive system." []
is_a: UBERON:0000058 ! duct
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0000079 ! male reproductive system
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0005906
name: serous sac
def: "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]" []
is_a: UBERON:0000062 ! organ
relationship: has_part UBERON:0000042 ! serous membrane
relationship: has_part UBERON:0002553 ! anatomical cavity

[Term]
id: UBERON:0005908
name: conjunctival sac
def: "A serous sac which is the aggregate of the conjunctiva plus the conjunctival space" []
synonym: "conjunctiva serous sac" EXACT []
synonym: "subbrillar sac" NARROW []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005906 ! serous sac
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0035639 ! ocular adnexa

[Term]
id: UBERON:0005910
name: transitional epithelium
def: "Multilaminar epithelium, which of consists of more than one layer of epithelial cells, in contact with a basement membrane, that can undergo distention and contraction without losing its integrity and consistency. Examples: urothelium.[FMA]" []
synonym: "epithelium transitionale" EXACT []
synonym: "urothelium" NARROW []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium

[Term]
id: UBERON:0005911
name: endo-epithelium
def: "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]" []
synonym: "endoderm-derived epithelium" EXACT []
synonym: "endoepithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000483 ! epithelium
intersection_of: develops_from UBERON:0000925 ! endoderm
relationship: develops_from UBERON:0000925 ! endoderm

[Term]
id: UBERON:0005913
name: zone of bone organ
synonym: "bone organ zone" EXACT []
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0005932
name: bulb of hair follicle
def: "Thickening of the proximal end of the hair follicle. Contains rapidly proliferating, rather undifferentiated matrix cells (transient amplifying cells), melanocytes and outer root sheath cells." []
synonym: "coat hair bulb" NARROW []
synonym: "hair bulb" EXACT []
synonym: "hair follicle bulb" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002073 ! hair follicle

[Term]
id: UBERON:0005933
name: hair root sheath
def: "." []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0005932 ! bulb of hair follicle

[Term]
id: UBERON:0005941
name: hair inner root sheath
def: "A multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle[MP]." []
synonym: "hair follicle inner root sheath" EXACT []
synonym: "inner root sheath" RELATED []
synonym: "inner root sheath of hair follicle" EXACT []
synonym: "inner sheath of hair follicle" EXACT []
synonym: "internal root sheath of hair follicle" EXACT []
is_a: UBERON:0005933 ! hair root sheath

[Term]
id: UBERON:0005942
name: hair outer root sheath
def: "A stratified epithelium that surrounds the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb." []
synonym: "external root sheath of hair follicle" EXACT []
synonym: "hair follicle outer root sheath" EXACT []
synonym: "ORS" RELATED []
synonym: "outer hair sheath" RELATED []
synonym: "outer root sheath" RELATED []
synonym: "outer root sheath of hair follicle" EXACT []
is_a: UBERON:0005933 ! hair root sheath

[Term]
id: UBERON:0005944
name: axial skeleton plus cranial skeleton
def: "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." []
synonym: "skeleton axiale" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0004288 ! skeleton
relationship: part_of UBERON:0011137 ! axial skeletal system

[Term]
id: UBERON:0005946
name: outflow tract of atrium
def: "An outflow tract that is part of a cardiac atrium." []
synonym: "outflow part of atrium" EXACT []
is_a: UBERON:0004145 ! outflow tract
intersection_of: UBERON:0004145 ! outflow tract
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium

[Term]
id: UBERON:0005953
name: outflow part of right ventricle
def: "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" []
synonym: "arterial cone" RELATED []
synonym: "conus arteriosus" RELATED []
synonym: "conus arteriosus (infundibulum)" EXACT []
synonym: "infundibulum" BROAD []
synonym: "infundibulum of right ventricle" EXACT []
synonym: "outflow tract of right ventricle" EXACT []
synonym: "pulmonary cone" RELATED []
synonym: "pulmonary conus" EXACT []
synonym: "pulmonary conus" RELATED []
synonym: "right ventricle pulmonary outflow tract" EXACT []
synonym: "right ventricular outflow tract" EXACT []
synonym: "RVOT" EXACT []
is_a: UBERON:0005337 ! outflow tract of ventricle
intersection_of: UBERON:0005337 ! outflow tract of ventricle
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: develops_from UBERON:0009889 ! secondary heart field
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: UBERON:0005956
name: outflow part of left ventricle
def: "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." []
synonym: "aortic vestibule" EXACT []
synonym: "heart left ventricle outflow tract" EXACT []
synonym: "left ventricular outflow" EXACT []
synonym: "left ventricular outflow tract" EXACT []
synonym: "LVOT" EXACT []
synonym: "outflow tract of left ventricle" EXACT []
synonym: "Sibson vestibule" EXACT []
synonym: "vestibulum aortae" EXACT []
is_a: UBERON:0005337 ! outflow tract of ventricle
intersection_of: UBERON:0005337 ! outflow tract of ventricle
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: UBERON:0005969
name: eye trabecular meshwork
def: "A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP]." []
synonym: "cribiform ligament" RELATED []
synonym: "eye trabecular meshwork" EXACT []
synonym: "Hueck's ligament" RELATED []
synonym: "iridis" RELATED []
synonym: "ligamentum peactin-tum iridis" RELATED []
synonym: "ligamentum pectinatum" RELATED []
synonym: "ligamentum pectinatum anguli iridocornealis" RELATED []
synonym: "ligamentum pectinatum iridis" RELATED []
synonym: "pectinate ligament" RELATED []
synonym: "pectinate ligament of iris" RELATED []
synonym: "reticulum trabeculare" EXACT []
synonym: "reticulum trabeculare sclerae" RELATED []
synonym: "scleral trabeculae" RELATED []
synonym: "scleral trabecular" RELATED []
synonym: "scleral trabecule" RELATED []
synonym: "scribiform ligament" RELATED []
synonym: "trabecular mesh" RELATED []
synonym: "trabecular meshwork" RELATED []
synonym: "trabecular meshwork of the eye" EXACT []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0003956 ! aqueous drainage system

[Term]
id: UBERON:0005971
name: amniotic fold
def: "A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong]." []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004874 ! somatopleure

[Term]
id: UBERON:0005983
name: heart layer
def: "The laminar structure of the heart" []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0005985
name: coronary vessel
def: "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" []
is_a: UBERON:0000055 ! vessel
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000055 ! vessel
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0005986
name: left branch of atrioventricular bundle
def: "The left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber[MP]." []
synonym: "crus sinistrum (fasciculi atrioventricularis)" EXACT []
synonym: "crus sinistrum fasciculi atrioventricularis" EXACT []
synonym: "left bundle branch" EXACT []
synonym: "left bundle branch of bundle of His" EXACT []
synonym: "left bundle of atrioventricular bundle" EXACT []
synonym: "left crus of atrioventricular bundle" EXACT []
synonym: "left posterior branch" EXACT []
synonym: "left posterior bundle" EXACT []
is_a: UBERON:0010131 ! conducting tissue of heart
is_a: UBERON:0015212 ! lateral structure
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0005987
name: right branch of atrioventricular bundle
def: "The right branch of the atrioventricular bundle that separates just below the bundle of His, descends the septal wall of the right ventricle and connects to the terminal Purkinje fibers[MP]." []
synonym: "crus dextrum (fasciculi atrioventricularis)" EXACT []
synonym: "crus dextrum fasciculi atrioventricularis" EXACT []
synonym: "right bundle" EXACT []
synonym: "right bundle branch" EXACT []
synonym: "right bundle branch of bundle of His" EXACT []
synonym: "right right crus of atrioventricular bundle" EXACT []
synonym: "right ventricular bundle" EXACT []
is_a: UBERON:0010131 ! conducting tissue of heart
is_a: UBERON:0015212 ! lateral structure
is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0006003
name: integumentary adnexa
def: "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." []
synonym: "adnexae cutis" RELATED []
synonym: "body hair or bristle" NARROW []
synonym: "skin adnexa" RELATED []
synonym: "skin adnexal structure" RELATED []
synonym: "skin appendage" RELATED []
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0006004
name: hair follicle matrix region
def: "The bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" []
synonym: "germinal matrix of hair bulb" EXACT []
synonym: "lower part of bulb of hair follicle" EXACT []
synonym: "lower zone of bulb of hair follicle" EXACT []
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010371 ! ecto-epithelium
relationship: part_of UBERON:0005932 ! bulb of hair follicle

[Term]
id: UBERON:0006008
name: fibrous ring of heart
def: "A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices" []
synonym: "annulus fibrosus cordis" RELATED []
synonym: "anulus fibrosus cordis" RELATED []
synonym: "anulus fibrosus of heart" EXACT []
synonym: "aortic annulus" RELATED []
synonym: "atrioventricular ring" RELATED []
synonym: "coronary tendon" RELATED []
synonym: "fibrous ring of heart" RELATED []
synonym: "Lower's ring" RELATED []
is_a: UBERON:0003837 ! thoracic segment connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006444 ! annulus fibrosus
intersection_of: UBERON:0006444 ! annulus fibrosus
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0006058
name: multi-limb segment region
def: "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." []
is_a: UBERON:0010758 ! subdivision of organism along appendicular axis
relationship: has_part UBERON:0002529 ! limb segment

[Term]
id: UBERON:0006082
name: fundus of urinary bladder
def: "The base or posterior surface of the urinary bladder contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice." []
synonym: "base of urinary bladder" EXACT []
synonym: "bladder dome" RELATED []
synonym: "fundus of bladder" BROAD []
synonym: "fundus vesicae" EXACT []
synonym: "urinary bladder base" EXACT []
synonym: "urinary bladder fundus" EXACT []
synonym: "urinary bladder fundus region" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0005760 ! urorectal septum
relationship: develops_from UBERON:0009845 ! urogenital sinus mesenchyme
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: UBERON:0006098
name: basal nuclear complex
def: "The deep nuclei of telencephalic origin found in the basal region of the forebrain" []
synonym: "basal ganglia" RELATED []
synonym: "basal ganglia (anatomic)" RELATED []
synonym: "basal nuclei" EXACT []
synonym: "basal nuclei of the forebrain" EXACT []
synonym: "corpus striatum (Savel'ev)" RELATED []
synonym: "ganglia basales" RELATED []
is_a: UBERON:0007245 ! nuclear complex of neuraxis
is_a: UBERON:0019264 ! gray matter of forebrain
relationship: part_of UBERON:0002743 ! basal forebrain

[Term]
id: UBERON:0006127
name: funiculus of spinal cord
def: "A funiculus of neuraxis that is part of a spinal cord." []
synonym: "spinal cord funiculus" EXACT []
synonym: "white column of spinal cord" EXACT []
is_a: UBERON:0006133 ! funiculus of neuraxis
intersection_of: UBERON:0006133 ! funiculus of neuraxis
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002318 ! white matter of spinal cord

[Term]
id: UBERON:0006133
name: funiculus of neuraxis
def: "The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans" []
is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0002316 ! white matter

[Term]
id: UBERON:0006173
name: pronephric proximal tubule
def: "A pronephric nephron tubule is an epithelial tube that is part of the pronephros" []
synonym: "pronephros proximal tubule" EXACT []
is_a: UBERON:0004134 ! proximal tubule
is_a: UBERON:0005310 ! pronephric nephron tubule
intersection_of: UBERON:0004134 ! proximal tubule
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0005309 ! pronephric nephron

[Term]
id: UBERON:0006175
name: pronephric distal tubule
def: "A pronephric nephron tubule is an epithelial tube that is part of the pronephros" []
is_a: UBERON:0004135 ! distal tubule
is_a: UBERON:0005310 ! pronephric nephron tubule
intersection_of: UBERON:0004135 ! distal tubule
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0005309 ! pronephric nephron

[Term]
id: UBERON:0006182
name: mesonephric glomerular mesangium
def: "The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus" []
is_a: UBERON:0002320 ! glomerular mesangium
intersection_of: UBERON:0002320 ! glomerular mesangium
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005326 ! mesonephric glomerulus vasculature

[Term]
id: UBERON:0006183
name: mesonephric glomerular capillary
def: "." []
is_a: UBERON:0004212 ! glomerular capillary
intersection_of: UBERON:0004212 ! glomerular capillary
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron
relationship: part_of UBERON:0005325 ! mesonephric glomerulus

[Term]
id: UBERON:0006189
name: mesonephric connecting tubule
def: "The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros" []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0005097 ! renal connecting tubule
is_a: UBERON:0005330 ! mesonephric nephron epithelium
intersection_of: UBERON:0005097 ! renal connecting tubule
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron

[Term]
id: UBERON:0006190
name: mesonephric distal tubule
def: "The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule" []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0004135 ! distal tubule
is_a: UBERON:0005330 ! mesonephric nephron epithelium
intersection_of: UBERON:0004135 ! distal tubule
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron

[Term]
id: UBERON:0006192
name: mesonephric proximal tubule
def: "The mesonephric proximal tubule extends from the capsule to the distal tubule" []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0004134 ! proximal tubule
is_a: UBERON:0005330 ! mesonephric nephron epithelium
intersection_of: UBERON:0004134 ! proximal tubule
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0005322 ! mesonephric nephron

[Term]
id: UBERON:0006206
name: iridocorneal angle
def: "Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP]." []
synonym: "anterior chamber angle" EXACT []
is_a: UBERON:0000015 ! anatomical boundary
relationship: part_of UBERON:0003956 ! aqueous drainage system

[Term]
id: UBERON:0006208
name: auditory hillocks
def: "A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head." []
synonym: "auditory hillock of Hiss" EXACT []
synonym: "auditory tubercles" RELATED []
synonym: "auricular hillock" RELATED []
synonym: "hillock of Hiss" RELATED []
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0006211
name: buccopharyngeal membrane
def: "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." []
synonym: "oral membrane" RELATED []
synonym: "oral plate" RELATED []
synonym: "oropharyngeal membrane" RELATED []
synonym: "pharyngeal membrane" RELATED []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003037 ! septum
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0006264 ! mouth-foregut junction

[Term]
id: UBERON:0006215
name: rhombic lip
def: "the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" []
synonym: "cerebellar anlage" RELATED []
synonym: "cerebellar primordium" RELATED []
synonym: "cerebellum primordium" RELATED []
synonym: "dorsal part of alar plate of metencephalon" RELATED []
synonym: "future cerebellum" RELATED []
synonym: "presumptive cerebellum" RELATED []
synonym: "rostral rhombic lip" RELATED []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0010092 ! future metencephalon

[Term]
id: UBERON:0006222
name: future diencephalon
def: "The foremost region of the future forebrain that develops into the diencephalon." []
synonym: "presumptive diencephalon" EXACT []
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0006240 ! future forebrain

[Term]
id: UBERON:0006232
name: facio-acoustic VII-VIII preganglion complex
synonym: "facio-acoustic preganglion complex" RELATED []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0005565 ! facio-acoustic neural crest
relationship: part_of UBERON:0001714 ! cranial ganglion

[Term]
id: UBERON:0006234
name: femur pre-cartilage condensation
def: "A femur endochondral element that is composed primarily of a pre-cartilage condensation." []
synonym: "femoral pre-cartilage condensation" RELATED []
is_a: UBERON:0005254 ! upper leg mesenchyme
is_a: UBERON:0005866 ! pre-cartilage condensation
is_a: UBERON:0010882 ! limb bone pre-cartilage condensation
is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation
is_a: UBERON:0015052 ! femur endochondral element
is_a: UBERON:0017650 ! developing mesenchymal structure

[Term]
id: UBERON:0006235
name: foregut-midgut junction
def: "An anatomical junctions that overlaps the foregut and midgut." []
is_a: UBERON:0007651 ! anatomical junction
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0006238
name: future brain
def: "The embryonic precursor of the brain." []
synonym: "brain rudiment" EXACT []
synonym: "embryonic brain" RELATED []
synonym: "encephalon" NARROW []
synonym: "presumptive brain" EXACT []
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0002346 ! neurectoderm

[Term]
id: UBERON:0006240
name: future forebrain
def: "A presumptive structure that has the potential to develop into a forebrain." []
synonym: "future prosencephalon" EXACT []
synonym: "presumptive forebrain" EXACT []
synonym: "presumptive prosencephalon" EXACT []
synonym: "prosencephalon" RELATED []
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0006238 ! future brain

[Term]
id: UBERON:0006242
name: gall bladder primordium
def: "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0001152 ! cystic duct
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001173 ! biliary tree
relationship: part_of UBERON:0004912 ! biliary bud

[Term]
id: UBERON:0006256
name: knee joint primordium
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0003321 ! mesenchyme of knee

[Term]
id: UBERON:0006264
name: mouth-foregut junction
def: "An anatomical junctions that overlaps the mouth and foregut." []
is_a: UBERON:0007651 ! anatomical junction
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0006266
name: nasolacrimal groove
def: "Groove between maxillary prominence and lateral nasal process." []
synonym: "naso-lacrimal groove" EXACT []
synonym: "s. lacrimalis maxillae" RELATED []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0019306 ! nose epithelium
relationship: develops_from UBERON:0012313 ! 1st arch maxillary ectoderm
relationship: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0006267
name: notochordal plate
def: "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0006268 ! notochordal process
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0006268
name: notochordal process
def: "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot" []
synonym: "chordamesoderm" RELATED []
synonym: "presumptive notochord" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0006273
name: otic pit
def: "the pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles" []
synonym: "otic cup" EXACT []
is_a: UBERON:0016566 ! pit
relationship: part_of UBERON:0003069 ! otic placode

[Term]
id: UBERON:0006292
name: shoulder joint primordium
is_a: UBERON:0003322 ! mesenchyme of shoulder
is_a: UBERON:0005856 ! developing mesenchymal condensation
relationship: develops_from UBERON:0003322 ! mesenchyme of shoulder
relationship: part_of UBERON:0003322 ! mesenchyme of shoulder

[Term]
id: UBERON:0006293
name: spleen primordium
def: "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." []
synonym: "left spleen primordium" NARROW []
synonym: "spleen mesenchyme" EXACT []
synonym: "splenic mesenchyme" EXACT []
synonym: "splenic primordium" EXACT []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: part_of UBERON:0005602 ! dorsal mesogastrium

[Term]
id: UBERON:0006311
name: chamber of eyeball
def: "A segment of the eyeball that is filled with refractive media" []
synonym: "chamber of eye" RELATED []
synonym: "eye chamber" EXACT []
synonym: "eyeball chamber" EXACT []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0006314
name: bodily fluid
def: "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." []
synonym: "body fluid" EXACT []
synonym: "fluid" BROAD []
is_a: UBERON:0000463 ! organism substance

[Term]
id: UBERON:0006331
name: brainstem nucleus
def: "A nucleus of brain that is part of a brainstem." []
synonym: "brain stem nucleus" RELATED []
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0002298 ! brainstem

[Term]
id: UBERON:0006334
name: posterior lateral line
def: "One of eight distinct lateral lines in the 4-day larva. A sensory system on the surface of the fish, consisting of small sensory patches (neuromasts) distributed in discrete lines over the body surface. The lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." []
synonym: "pll" EXACT []
is_a: UBERON:0010202 ! lateral line
disjoint_from: UBERON:2001470 ! anterior lateral line

[Term]
id: UBERON:0006338
name: lateral ventricle choroid plexus stroma
def: "A choroid plexus stroma that is part of a lateral ventricle." []
is_a: UBERON:0005206 ! choroid plexus stroma
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0005206 ! choroid plexus stroma
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle

[Term]
id: UBERON:0006340
name: fourth ventricle choroid plexus stroma
def: "A choroid plexus stroma that is part of a fourth ventricle." []
is_a: UBERON:0005206 ! choroid plexus stroma
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0005206 ! choroid plexus stroma
intersection_of: part_of UBERON:0002422 ! fourth ventricle
relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle
relationship: part_of UBERON:0002422 ! fourth ventricle

[Term]
id: UBERON:0006341
name: outer renal medulla peritubular capillary
def: "A peritubular capillary that is part of a outer medulla of kidney." []
synonym: "kidney outer medulla peritubular capillary" EXACT []
is_a: UBERON:0005272 ! peritubular capillary
intersection_of: UBERON:0005272 ! peritubular capillary
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0006376
name: premacula segment of distal straight tubule
def: "." []
synonym: "distal straight tubule premacula segment" EXACT []
synonym: "kidney medulla loop of Henle ascending limb thick segment" EXACT []
synonym: "medullary thick ascending limb of Henle's loop" EXACT []
synonym: "renal medulla loop of Henle ascending limb thick segment" EXACT []
synonym: "renal medulla thick ascending limb" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule
is_a: UBERON:0008408 ! distal tubular epithelium
relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0006541 ! outer medulla inner stripe loop of henle
relationship: part_of UBERON:0006542 ! outer medulla outer stripe loop of henle

[Term]
id: UBERON:0006435
name: os penis
def: "the unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species" []
synonym: "baculum" EXACT []
synonym: "os baculum" EXACT []
synonym: "penile bone" EXACT []
synonym: "penis bone" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0007719 ! bone of reproductive organ
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0000989 ! penis
relationship: part_of UBERON:0000989 ! penis

[Term]
id: UBERON:0006444
name: annulus fibrosus
def: "A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart)." []
synonym: "anulus" BROAD []
synonym: "anulus fibrosus" EXACT []
synonym: "fibrocartilaginous ring" EXACT []
synonym: "fibrous ring" RELATED []
is_a: UBERON:0001995 ! fibrocartilage

[Term]
id: UBERON:0006524
name: alveolar system
def: "System pertaining to a bronchus and alveoli." []
synonym: "bronchoalveolar system" RELATED []
synonym: "pulmonary alveolar system" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0006525
name: left lung alveolar system
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0006524 ! alveolar system

[Term]
id: UBERON:0006526
name: right lung alveolar system
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0006524 ! alveolar system

[Term]
id: UBERON:0006534
name: renal convoluted tubule
def: "Any region of a nephron tubule that is convoluted. Examples: distal convoluted tubule, proximal convoluted tuble." []
synonym: "convoluted tubule" EXACT []
synonym: "kidney convoluted tubule" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule

[Term]
id: UBERON:0006541
name: outer medulla inner stripe loop of henle
def: "A loop of Henle that is part of a kidney outer medulla inner stripe." []
is_a: UBERON:0034996 ! outer renal medulla loop of henle
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0004201 ! kidney outer medulla inner stripe
relationship: part_of UBERON:0004201 ! kidney outer medulla inner stripe

[Term]
id: UBERON:0006542
name: outer medulla outer stripe loop of henle
def: "A loop of Henle that is part of a kidney outer medulla outer stripe." []
is_a: UBERON:0034996 ! outer renal medulla loop of henle
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0004202 ! kidney outer medulla outer stripe
relationship: part_of UBERON:0004202 ! kidney outer medulla outer stripe

[Term]
id: UBERON:0006544
name: kidney vasculature
def: "A vasculature that is part of a kidney." []
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0006553
name: renal duct
def: "A tube in the kidney that collect and transport urine." []
is_a: UBERON:0000058 ! duct
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0006555
name: excretory tube
def: "A tube that is part of a excretory system." []
is_a: UBERON:0000025 ! tube
intersection_of: UBERON:0000025 ! tube
intersection_of: part_of UBERON:0001008 ! renal system
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0006558
name: lymphatic part of lymphoid system
def: "An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system." []
synonym: "lymphatic system" EXACT []
synonym: "lymphatic tree system" EXACT []
synonym: "lymporeticular system" RELATED []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001009 ! circulatory system
relationship: part_of UBERON:0002465 ! lymphoid system

[Term]
id: UBERON:0006561
name: non-lymphatic part of lymphoid system
def: "An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels.." []
synonym: "non-lymphatic lymphoid system" EXACT []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0002465 ! lymphoid system

[Term]
id: UBERON:0006562
name: pharynx
def: "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." []
synonym: "anterior part of foregut" RELATED []
synonym: "pharyngeal tube" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract

[Term]
id: UBERON:0006566
name: left ventricle myocardium
def: "A myocardium that is part of a left ventricle of a heart." []
synonym: "Left ventricular myocardium" EXACT []
synonym: "myocardium of left ventricle" EXACT []
is_a: UBERON:0001083 ! myocardium of ventricle
intersection_of: UBERON:0001083 ! myocardium of ventricle
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: UBERON:0006567
name: right ventricle myocardium
def: "A myocardium that is part of a right ventricle of a heart." []
synonym: "myocardium of right ventricle" EXACT []
synonym: "Right ventricular myocardium" EXACT []
is_a: UBERON:0001083 ! myocardium of ventricle
intersection_of: UBERON:0001083 ! myocardium of ventricle
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: UBERON:0006568
name: hypothalamic nucleus
def: "A nucleus of brain that is part of a hypothalamus." []
synonym: "nucleus of hypothalamus" EXACT []
is_a: UBERON:0006569 ! diencephalic nucleus
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0001898 ! hypothalamus
relationship: part_of UBERON:0001898 ! hypothalamus

[Term]
id: UBERON:0006569
name: diencephalic nucleus
def: "A nucleus of brain that is part of a diencephalon." []
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0006585
name: vestibular organ
def: "An organ that is part of a vestibular system." []
synonym: "balance organ" EXACT []
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0004681 ! vestibular system
relationship: part_of UBERON:0000012 ! somatic nervous system
relationship: part_of UBERON:0004681 ! vestibular system

[Term]
id: UBERON:0006598
name: presumptive structure
def: "Portion of embryonic tissue determined by fate mapping to become a structure." []
synonym: "future structure" EXACT []
synonym: "presumptive structures" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0006614
name: aponeurosis
def: "A sheet of extracellular matrix." []
synonym: "aponeuroses" RELATED []
synonym: "aponeurotic" RELATED []
is_a: UBERON:0000158 ! membranous layer
relationship: part_of UBERON:0001630 ! muscle organ

[Term]
id: UBERON:0006615
name: venous sinus
def: "A large vein or channel for the circulation of venous blood" []
synonym: "blood sinus" RELATED []
is_a: UBERON:0003920 ! venous blood vessel

[Term]
id: UBERON:0006642
name: muscle layer of oviduct
def: "A muscle layer that is part of a fallopian tube." []
synonym: "muscle layer of fallopian tube" EXACT []
synonym: "muscle layer of oviduct" EXACT []
synonym: "muscle layer of uterine tube" EXACT []
synonym: "muscular coat of uterine tube" EXACT []
synonym: "muscular layer of uterine tube" EXACT []
synonym: "muscularis of uterine tube" EXACT []
synonym: "tunica muscularis (Tuba uterina)" EXACT []
synonym: "tunica muscularis tubae uterinae" EXACT []
synonym: "uterine tubal muscularis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0006645
name: adventitia of epididymis
def: "An adventitia that is part of a epididymis." []
synonym: "epididymis adventitia" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005742 ! adventitia
intersection_of: UBERON:0005742 ! adventitia
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis

[Term]
id: UBERON:0006646
name: muscle layer of epididymis
def: "A muscle layer that is part of a epididymis." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis

[Term]
id: UBERON:0006648
name: adventitia of seminal vesicle
def: "An adventitia that is part of a seminal vesicle." []
synonym: "adventitia of seminal gland" EXACT []
synonym: "seminal vesicle adventitia" EXACT []
synonym: "tunica adventitia (vesicula seminalis)" EXACT []
synonym: "tunica adventitia glandulae vesiculosae" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005742 ! adventitia
intersection_of: UBERON:0005742 ! adventitia
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle

[Term]
id: UBERON:0006652
name: muscular layer of vagina
synonym: "muscular coat of vagina" EXACT []
synonym: "tunica muscularis vaginae" EXACT []
synonym: "vaginal muscularis" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0006660
name: muscular coat
def: "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." []
synonym: "muscular coat" RELATED []
synonym: "muscular layer" EXACT []
synonym: "muscularis" RELATED []
synonym: "muscularis externa" RELATED []
synonym: "muscularis layer" EXACT []
synonym: "muscularis propria" RELATED []
synonym: "transverse muscular fibers" RELATED []
synonym: "tunica externa" RELATED []
synonym: "tunica muscularis" EXACT []
synonym: "tunica muscularis" RELATED []
is_a: UBERON:0018260 ! layer of muscle tissue

[Term]
id: UBERON:0006661
name: epicranial aponeurosis
def: "The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance." []
synonym: "aponeurosis epicranialis" EXACT []
synonym: "aponeurosis of epicranius" EXACT []
synonym: "cranial aponeurosis" RELATED []
synonym: "epicranial aponeurosis" EXACT []
synonym: "epicranial aponeurosis" RELATED []
synonym: "epicranius aponeurosis" EXACT []
synonym: "galea aponeurosis" RELATED []
synonym: "galea aponeurotica" EXACT []
synonym: "galea aponeurotica; aponeurosis epicranialis" RELATED []
synonym: "galeal aponeurosis" RELATED []
is_a: UBERON:0006614 ! aponeurosis
relationship: part_of UBERON:0000403 ! scalp

[Term]
id: UBERON:0006686
name: spinal vein
def: "A vein that is part of a vertebral column." []
synonym: "spinal branch" RELATED []
synonym: "Spinal vein" EXACT []
synonym: "vena spinalis" EXACT []
is_a: UBERON:0001638 ! vein
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0001130 ! vertebral column
relationship: part_of UBERON:0001130 ! vertebral column

[Term]
id: UBERON:0006694
name: cerebellum vasculature
def: "A vasculature that is part of a cerebellum." []
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: UBERON:0006717
name: autopodial skeleton
def: "The collection of all skeletal elements in an autopodium region." []
synonym: "autopod skeleton" EXACT []
synonym: "autopodial skeleton" EXACT []
synonym: "autopodium" RELATED []
synonym: "skeletal parts of autopod" EXACT []
synonym: "skeleton of autopod" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010712 ! limb skeleton subdivision
relationship: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0004381 ! skeleton of limb

[Term]
id: UBERON:0006725
name: spiral ligament
def: "A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous cochlear duct to the bony spiral canal of the cochlea. Its spiral ligament fibrocytes function in conjunction with the stria vascularis to mediate cochlear ion homeostasis." []
synonym: "ligamentum spirale ductus cochlearis" EXACT []
synonym: "spiral cochlear ligament" EXACT []
synonym: "spiral ligament of cochlea" EXACT []
synonym: "spiral ligament of cochlear duct" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0008845 ! nonskeletal ligament
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth

[Term]
id: UBERON:0006763
name: epithelium of conjunctiva
def: "Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue" []
synonym: "conjunctiva epithelium" EXACT []
synonym: "conjunctival epithelium" EXACT []
is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva

[Term]
id: UBERON:0006799
name: glandular epithelium
def: "An epithelium that is composed primarily of secretory cells." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0006815
name: areolar connective tissue
def: "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." []
synonym: "areolar tissue" RELATED []
synonym: "loose areolar connective tissue" EXACT []
synonym: "loose connective tissue" RELATED []
is_a: UBERON:0011825 ! loose connective tissue
relationship: part_of UBERON:0000030 ! lamina propria

[Term]
id: UBERON:0006846
name: surface groove
def: "A furrow or an incomplete tube." []
synonym: "groove" RELATED []
is_a: UBERON:0003102 ! surface structure

[Term]
id: UBERON:0006851
name: renal cortex peritubular capillary
def: "A peritubular capillary that is part of a cortex of kidney." []
synonym: "kidney cortex peritubular capillary" EXACT []
is_a: UBERON:0005272 ! peritubular capillary
intersection_of: UBERON:0005272 ! peritubular capillary
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0006853
name: renal cortex tubule
def: "A region of nephron tubule that is part of a cortex of kidney." []
synonym: "cortical tubule" RELATED []
synonym: "kidney cortex tubule" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule
intersection_of: UBERON:0007685 ! region of nephron tubule
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0006854
name: distal straight tubule postmacula segment
def: "." []
synonym: "cortical thick ascending limb of Henle's loop" EXACT []
synonym: "kidney cortex loop of Henle ascending limb thick segment" EXACT []
synonym: "renal cortex loop of Henle ascending limb thick segment" EXACT []
synonym: "renal cortex thick ascending limb" EXACT []
is_a: UBERON:0006853 ! renal cortex tubule
is_a: UBERON:0008408 ! distal tubular epithelium
relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0006853 ! renal cortex tubule

[Term]
id: UBERON:0006855
name: muscular coat of ureter
def: "A muscular coat that is part of a ureter." []
synonym: "muscular coat of ureter" EXACT []
synonym: "muscular layer of ureter" EXACT []
synonym: "muscularis of ureter" EXACT []
synonym: "tunica muscularis (ureter)" EXACT []
synonym: "tunica muscularis ureteris" EXACT []
synonym: "ureteral smooth muscle layer" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0009916 ! wall of ureter

[Term]
id: UBERON:0006858
name: adrenal/interrenal gland
def: "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]" []
synonym: "adrenal - interrenal gland" RELATED []
synonym: "adrenal gland - interrenal gland" EXACT []
synonym: "adrenal gland/interrenal tissue" EXACT []
synonym: "suprarenal gland - interrenal gland" RELATED []
is_a: UBERON:0002368 ! endocrine gland
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0010074 ! chromaffin system

[Term]
id: UBERON:0006862
name: diaphysis of femur
def: "A diaphysis that is part of a femur[Automatically generated definition]." []
synonym: "body of femur" EXACT []
synonym: "corpus femoris" EXACT []
synonym: "femoral diaphysis" EXACT []
synonym: "femoral shaft" EXACT []
synonym: "shaft of femur" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004769 ! diaphysis
intersection_of: UBERON:0004769 ! diaphysis
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur

[Term]
id: UBERON:0006863
name: proximal metaphysis of femur
def: "A proximal metaphysis that is part of a femur." []
is_a: UBERON:0004378 ! proximal metaphysis
is_a: UBERON:0006865 ! metaphysis of femur
intersection_of: UBERON:0004378 ! proximal metaphysis
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0006862 ! diaphysis of femur

[Term]
id: UBERON:0006865
name: metaphysis of femur
def: "A metaphysis that is part of a femur." []
synonym: "femoral metaphysis" EXACT []
is_a: UBERON:0001438 ! metaphysis
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001438 ! metaphysis
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0006862 ! diaphysis of femur

[Term]
id: UBERON:0006866
name: terminal part of digestive tract
def: "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." []
synonym: "rectal part of digestive tract" RELATED []
synonym: "rectum" NARROW []
synonym: "terminal section of digestive tract" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001046 ! hindgut

[Term]
id: UBERON:0006868
name: seminal fluid secreting gland
def: "A gland that secretes a seminal fluid." []
is_a: UBERON:0005399 ! male reproductive gland
relationship: part_of UBERON:0006947 ! male genital duct

[Term]
id: UBERON:0006871
name: footplate
def: "the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw)" []
synonym: "distal part of hindlimb bud" RELATED []
synonym: "foot disk" RELATED []
synonym: "foot plate" EXACT []
is_a: UBERON:0010130 ! autopod plate
relationship: develops_from UBERON:0005418 ! hindlimb bud

[Term]
id: UBERON:0006872
name: handplate apical ectodermal ridge
def: "An apical ectodermal ridge that is part of a handplate." []
is_a: UBERON:0004356 ! apical ectodermal ridge
intersection_of: UBERON:0004356 ! apical ectodermal ridge
intersection_of: part_of UBERON:0006875 ! handplate
relationship: part_of UBERON:0006875 ! handplate

[Term]
id: UBERON:0006875
name: handplate
def: "An autopod plate that has the potential to develop into a manus." []
synonym: "distal part of forelimb bud" RELATED []
synonym: "hand plate" EXACT []
is_a: UBERON:0010130 ! autopod plate
relationship: develops_from UBERON:0005417 ! forelimb bud

[Term]
id: UBERON:0006876
name: vasculature of organ
def: "A vasculature that is part of a organ." []
synonym: "organ vasculature" EXACT []
synonym: "set of blood vessels of organ" EXACT []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000062 ! organ
relationship: part_of UBERON:0000062 ! organ

[Term]
id: UBERON:0006877
name: vasculature of liver
def: "A vasculature that is part of a liver." []
synonym: "hepatic vascular element" RELATED []
synonym: "hepatic vasculature" EXACT []
synonym: "liver vascular element" RELATED []
synonym: "liver vascular system" RELATED []
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0006904
name: head mesenchyme from mesoderm
def: "A head mesenchyme that develops_from a mesoderm." []
synonym: "cranial mesoderm" RELATED []
synonym: "head mesenchyme derived from mesoderm" EXACT []
synonym: "head mesenchyme from head mesoderm" EXACT []
synonym: "head mesenchyme from mesoderm" EXACT []
synonym: "head mesoderm" RELATED []
synonym: "mesenchyme derived from head mesoderm" EXACT []
synonym: "mesenchyme from head mesoderm" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005253 ! head mesenchyme
intersection_of: UBERON:0005253 ! head mesenchyme
intersection_of: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0003063 ! prechordal plate

[Term]
id: UBERON:0006905
name: mandibular process mesenchyme
def: "Mesenchyme that is part of a mandibular prominence." []
synonym: "mesenchyme of mandibular process" EXACT []
synonym: "mesenchyme of mandibular prominence" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005253 ! head mesenchyme
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0005867 ! mandibular prominence
relationship: part_of UBERON:0005867 ! mandibular prominence

[Term]
id: UBERON:0006914
name: squamous epithelium
def: "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0006915
name: stratified squamous epithelium
def: "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]" []
synonym: "epithelium stratificatum squamosum" EXACT []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium

[Term]
id: UBERON:0006916
name: non-keratinized epithelium of tongue
def: "A non-keratinized stratified squamous epithelium that is part of a tongue." []
is_a: UBERON:0006919 ! tongue squamous epithelium
is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium
intersection_of: UBERON:0010304 ! non-keratinized stratified squamous epithelium
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0006919
name: tongue squamous epithelium
def: "A squamous epithelium that is part of a tongue." []
synonym: "squamous epithelium of tongue" EXACT []
is_a: UBERON:0002424 ! oral epithelium
is_a: UBERON:0003357 ! epithelium of tongue
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0006914 ! squamous epithelium
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0005020 ! mucosa of tongue

[Term]
id: UBERON:0006920
name: esophagus squamous epithelium
def: "A squamous epithelium that is part of a esophagus." []
synonym: "esophageal squamous epithelium" RELATED []
synonym: "squamous epithelium of esophagus" RELATED []
synonym: "squamous oesophageal epithelium" RELATED []
is_a: UBERON:0001976 ! epithelium of esophagus
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0006914 ! squamous epithelium
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0006921
name: stomach squamous epithelium
def: "A squamous epithelium that is part of a stomach." []
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0001276 ! epithelium of stomach
intersection_of: UBERON:0006914 ! squamous epithelium
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: UBERON:0006922
name: cervix squamous epithelium
def: "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." []
synonym: "cervical squamous epithelium" EXACT []
is_a: UBERON:0004801 ! cervix epithelium
is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium
intersection_of: UBERON:0006914 ! squamous epithelium
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix

[Term]
id: UBERON:0006923
name: vagina squamous epithelium
def: "A squamous epithelium that is part of a vagina." []
synonym: "vaginal squamous epithelium" EXACT []
is_a: UBERON:0001344 ! epithelium of vagina
is_a: UBERON:0006915 ! stratified squamous epithelium
intersection_of: UBERON:0006914 ! squamous epithelium
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0006924
name: stomach glandular epithelium
def: "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." []
synonym: "epithelium of gastric gland" NARROW []
synonym: "gastric gland epithelium" RELATED []
is_a: UBERON:0001276 ! epithelium of stomach
is_a: UBERON:0006929 ! glandular columnar epithelium
intersection_of: UBERON:0006799 ! glandular epithelium
intersection_of: part_of UBERON:0000945 ! stomach
relationship: has_part UBERON:0000325 ! gastric gland
relationship: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0006931 ! stomach glandular region mucosa

[Term]
id: UBERON:0006925
name: digestive gland
def: "A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion." []
synonym: "digestive system gland" EXACT []
is_a: UBERON:0002368 ! endocrine gland
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0002368 ! endocrine gland
intersection_of: part_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0006929
name: glandular columnar epithelium
def: "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]" []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0006799 ! glandular epithelium

[Term]
id: UBERON:0006931
name: stomach glandular region mucosa
def: "stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." []
synonym: "stomach glandular region glandular mucous membrane" EXACT []
is_a: UBERON:0001199 ! mucosa of stomach
intersection_of: UBERON:0001199 ! mucosa of stomach
intersection_of: part_of UBERON:0011953 ! stomach glandular region
relationship: part_of UBERON:0011953 ! stomach glandular region

[Term]
id: UBERON:0006932
name: vestibular epithelium
def: "An epithelium that is part of a vestibular labyrinth." []
synonym: "epithelium of vestibular labyrinth" EXACT []
synonym: "inner ear vestibular component epithelium" EXACT []
synonym: "vestibular sensory epithelium" EXACT []
is_a: UBERON:0006934 ! sensory epithelium
is_a: UBERON:0006937 ! inner ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001862 ! vestibular labyrinth
relationship: part_of UBERON:0001862 ! vestibular labyrinth

[Term]
id: UBERON:0006934
name: sensory epithelium
def: "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." []
synonym: "neuroepithelium" RELATED []
is_a: UBERON:0000488 ! atypical epithelium
relationship: part_of UBERON:0000010 ! peripheral nervous system

[Term]
id: UBERON:0006935
name: crista ampullaris neuroepithelium
def: "An epithelium that is part of a crista ampullaris." []
synonym: "ampullary crest neuroepithelium" RELATED []
synonym: "epithelium of crista of ampulla of semicircular duct of membranous labyrinth" EXACT []
is_a: UBERON:0006932 ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004721 ! crista ampullaris
relationship: part_of UBERON:0004721 ! crista ampullaris

[Term]
id: UBERON:0006937
name: inner ear epithelium
def: "the epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals" []
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0015807 ! ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001846 ! internal ear
relationship: part_of UBERON:0001846 ! internal ear

[Term]
id: UBERON:0006938
name: pinna surface epithelium
def: "An epithelium that is part of a pinna." []
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015814 ! outer ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001757 ! pinna
relationship: part_of UBERON:0001757 ! pinna

[Term]
id: UBERON:0006947
name: male genital duct
def: "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra." []
synonym: "sperm duct" EXACT []
synonym: "sperm ducts" EXACT []
is_a: UBERON:0005904 ! duct of male reproductive system
is_a: UBERON:0015212 ! lateral structure
relationship: part_of UBERON:0004054 ! internal male genitalia

[Term]
id: UBERON:0006955
name: uterine epithelium
def: "An epithelium that is part of a uterus." []
synonym: "uterus epithelium" RELATED []
is_a: UBERON:0004804 ! oviduct epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0006960
name: ovary stroma
def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." []
synonym: "interstitial tissue of ovary" EXACT []
synonym: "ovarian stroma" EXACT []
synonym: "ovary stroma" EXACT []
synonym: "stroma of the ovary" EXACT []
synonym: "stroma ovarica" EXACT []
synonym: "stroma ovarii" RELATED []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0006964
name: pars distalis of adenohypophysis
def: "The distal part of adenohypophysis: the part that makes up the main body of the gland." []
synonym: "anterior lobe" RELATED []
synonym: "DHP" BROAD []
synonym: "distal part of hypophysis" EXACT []
synonym: "distal part of the hypophysis" RELATED []
synonym: "pars anterior" BROAD []
synonym: "pars anterior of adenohypophysis" EXACT []
synonym: "pars distalis" RELATED []
synonym: "pars distalis (glandula pituitaria)" EXACT []
synonym: "pars distalis (hypophysis)" RELATED []
synonym: "pars distalis adenohypophyseos" RELATED []
synonym: "pars distalis adenohypophysis" EXACT []
synonym: "pars distalis lobi anterioris hypophyseos" RELATED []
synonym: "pars distalis of anterior lobe of pituitary gland" EXACT []
synonym: "pars glandularis" RELATED []
synonym: "pars glandularis of adenohypophysis" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
relationship: part_of UBERON:0002196 ! adenohypophysis

[Term]
id: UBERON:0006965
name: vascular cord
def: "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0014903 ! primordial vasculature

[Term]
id: UBERON:0006966
name: coronary capillary
def: "A capillary that is part of the coronary system." []
synonym: "heart capillary" EXACT []
is_a: UBERON:0001982 ! capillary
is_a: UBERON:0003498 ! heart blood vessel
intersection_of: UBERON:0001982 ! capillary
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0018674 ! heart vasculature

[Term]
id: UBERON:0006984
name: anatomical surface
def: "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n" []
is_a: UBERON:0000466 ! immaterial anatomical entity

[Term]
id: UBERON:0007005
name: cardiac mesoderm
def: "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." []
synonym: "cardiogenic mesoderm" RELATED []
synonym: "cardiogenic region" RELATED []
synonym: "heart primordia" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: part_of UBERON:0004140 ! primary heart field
relationship: part_of UBERON:0009881 ! anterior lateral plate mesoderm

[Term]
id: UBERON:0007010
name: cleaving embryo
def: "Organism at the cleavage stage." []
is_a: UBERON:0000922 ! embryo

[Term]
id: UBERON:0007026
name: presumptive gut
synonym: "embryonic digestive tube" RELATED []
synonym: "future digestive tract" EXACT []
synonym: "future digestive tube" EXACT []
synonym: "future gut" EXACT []
synonym: "primitive gut" EXACT []
synonym: "primordial digestive tube" RELATED []
synonym: "primordial gut" RELATED []
is_a: UBERON:0006598 ! presumptive structure

[Term]
id: UBERON:0007037
name: mechanosensory system
is_a: UBERON:0001032 ! sensory system

[Term]
id: UBERON:0007098
name: mandibular neural crest
def: "Cranial neural crest that migrates into the mandibular arch." []
is_a: UBERON:0003099 ! cranial neural crest
relationship: part_of UBERON:0003852 ! rhombencephalon neural crest

[Term]
id: UBERON:0007099
name: hyoid neural crest
def: "Cranial neural crest that migrates into the hyoid arch." []
synonym: "hyoid crest" EXACT []
is_a: UBERON:0003099 ! cranial neural crest
relationship: part_of UBERON:0003852 ! rhombencephalon neural crest

[Term]
id: UBERON:0007100
name: primary circulatory organ
def: "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." []
synonym: "adult heart" RELATED []
synonym: "dorsal tube" NARROW []
synonym: "heart" NARROW []
is_a: UBERON:0015228 ! circulatory organ

[Term]
id: UBERON:0007119
name: neck of femur
def: "The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward." []
synonym: "collum femoris" RELATED []
synonym: "femoral neck" EXACT []
synonym: "femur neck" RELATED []
synonym: "neck of the femur" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005055 ! zone of long bone
is_a: UBERON:0018664 ! neck of bone element
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0006863 ! proximal metaphysis of femur

[Term]
id: UBERON:0007122
name: pharyngeal pouch 1
def: "A pharyngeal pouch that is between pharyngeal arches 1 and 2." []
synonym: "1st arch branchial pouch" EXACT []
synonym: "1st arch branchial pouch endoderm" EXACT []
synonym: "1st arch pouch endoderm" EXACT []
synonym: "1st branchial pouch" EXACT []
synonym: "1st pharyngeal pouch endoderm" EXACT []
synonym: "first arch pharyngeal pouch" EXACT []
synonym: "first pharyngeal pouch" RELATED []
synonym: "first visceral pouch" EXACT []
synonym: "hyomandibular pouch" EXACT []
synonym: "pharyngeal pouches 1" EXACT []
synonym: "visceral pouch 1" EXACT []
is_a: UBERON:0004117 ! pharyngeal pouch

[Term]
id: UBERON:0007128
name: glomeral mesenchyme
def: "Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm." []
synonym: "corpuscle" RELATED []
synonym: "glomerulus" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0007134
name: trunk ganglion
def: "Ganglion which is located in the trunk." []
synonym: "body ganglion" EXACT []
synonym: "trunk ganglia" EXACT []
is_a: UBERON:0000045 ! ganglion
is_a: UBERON:0005177 ! trunk region element
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0007135
name: neural keel
def: "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." []
synonym: "presumptive central nervous system" RELATED []
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0003075 ! neural plate

[Term]
id: UBERON:0007177
name: lamina propria of mucosa of colon
def: "A lamina propria that is part of a colonic mucosa." []
synonym: "colonic lamina propria" EXACT []
synonym: "lamina propria mucosae of colon" EXACT []
synonym: "lamina propria of colonic mucosa" EXACT []
synonym: "lamina propria of colonic mucous membrane" EXACT []
is_a: UBERON:0011189 ! lamina propria of large intestine
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0000317 ! colonic mucosa
relationship: part_of UBERON:0000317 ! colonic mucosa

[Term]
id: UBERON:0007188
name: mesothelium of serous pericardium
def: "A mesothelium that is part of a serous pericardium." []
synonym: "mesothelium of pericardium" EXACT []
synonym: "pericardial mesothelium" EXACT []
synonym: "serous pericardium mesothelium" EXACT []
is_a: UBERON:0003388 ! mesothelium of pericardial cavity
intersection_of: UBERON:0001136 ! mesothelium
intersection_of: part_of UBERON:0002357 ! serous pericardium
relationship: part_of UBERON:0002357 ! serous pericardium

[Term]
id: UBERON:0007195
name: stroma of bone marrow
def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." []
synonym: "bone marrow stroma" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: has_part UBERON:0000332 ! yellow bone marrow
relationship: has_part UBERON:0003909 ! sinusoid
relationship: part_of UBERON:0002371 ! bone marrow

[Term]
id: UBERON:0007196
name: tracheobronchial tree
def: "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." []
synonym: "arbor tracheobronchialis" EXACT []
synonym: "tracheobronchial system" RELATED []
is_a: CARO:0000003 ! anatomical structure
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: has_part UBERON:0002185 ! bronchus
relationship: has_part UBERON:0003126 ! trachea
relationship: has_part UBERON:0007592 ! ciliated columnar epithelium
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0007197
name: hermaphroditic organism
def: "multicellular organism that can produce both male and female gametes." []
synonym: "dioecious organism" RELATED []
synonym: "hermaphrodite" RELATED []
is_a: UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0007204
name: brachiocephalic vasculature
def: "The vasculature consisting of brachiocephalic arteries and veins." []
is_a: UBERON:0002049 ! vasculature

[Term]
id: UBERON:0007213
name: mesenchyme derived from head neural crest
def: "Mesenchyme that develops_from a cranial neural crest." []
synonym: "head mesenchyme from cranial neural crest" EXACT []
synonym: "head mesenchyme from neural crest" EXACT []
synonym: "head neural crest derived mesenchyme" EXACT []
is_a: UBERON:0005253 ! head mesenchyme
is_a: UBERON:0014387 ! mesenchyme derived from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0003099 ! cranial neural crest
relationship: develops_from UBERON:0003099 ! cranial neural crest

[Term]
id: UBERON:0007214
name: mesenchyme derived from trunk neural crest
def: "Mesenchyme that develops_from a trunk neural crest." []
synonym: "trunk mesenchyme from neural crest" EXACT []
synonym: "trunk neural crest derived mesenchyme" EXACT []
is_a: UBERON:0005256 ! trunk mesenchyme
is_a: UBERON:0014387 ! mesenchyme derived from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0003083 ! trunk neural crest
relationship: develops_from UBERON:0003083 ! trunk neural crest

[Term]
id: UBERON:0007237
name: 1st arch mandibular component
synonym: "ventral mandibular arch" RELATED []
synonym: "ventral pharyngeal arch 1" EXACT []
synonym: "ventral visceral arch 1" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004362 ! pharyngeal arch 1

[Term]
id: UBERON:0007238
name: 1st arch maxillary component
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004362 ! pharyngeal arch 1

[Term]
id: UBERON:0007240
name: tunica adventitia of artery
def: "A tunica adventitia that is part of a artery." []
synonym: "arterial adventitia" EXACT []
synonym: "tunica externa (adventitia)(arteriae)" EXACT []
is_a: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0000415 ! artery wall
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0007241
name: tunica adventitia of vein
def: "A tunica adventitia that is part of a vein." []
synonym: "tunica externa (adventitia)(venae)" EXACT []
synonym: "venous adventitia" EXACT []
is_a: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein

[Term]
id: UBERON:0007242
name: tunica intima of vein
def: "A tunica intima that is part of a vein." []
synonym: "tunica interna (intima)(venae)" EXACT []
synonym: "venous intima" EXACT []
is_a: UBERON:0001919 ! endothelium of vein
is_a: UBERON:0002523 ! tunica intima
intersection_of: UBERON:0002523 ! tunica intima
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein

[Term]
id: UBERON:0007245
name: nuclear complex of neuraxis
def: "Gray matter of the central nervous system which is a collection of clustered nuclei." []
synonym: "cluster of neural nuclei" RELATED []
synonym: "neural nuclei" RELATED []
synonym: "nuclear complex" RELATED []
is_a: UBERON:0002020 ! gray matter

[Term]
id: UBERON:0007267
name: trachea pre-cartilage rings
def: "A pre-cartilage condensation that is part of a trachea." []
is_a: UBERON:0005866 ! pre-cartilage condensation
is_a: UBERON:0009505 ! mesenchyme of trachea
intersection_of: UBERON:0005866 ! pre-cartilage condensation
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from UBERON:0009505 ! mesenchyme of trachea
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0007269
name: pectoral appendage musculature
def: "Any collection of muscles that is part of a pectoral appendage." []
synonym: "pectoral fin muscle" NARROW []
synonym: "pectoral fin musculature" NARROW []
is_a: UBERON:0007271 ! appendage musculature
is_a: UBERON:0014793 ! musculature of pectoral complex
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage

[Term]
id: UBERON:0007270
name: pelvic appendage musculature
def: "Any collection of muscles that is part of a pelvic appendage." []
synonym: "pelvic fin musculature" NARROW []
is_a: UBERON:0007271 ! appendage musculature
is_a: UBERON:0014792 ! musculature of pelvic complex
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0004709 ! pelvic appendage

[Term]
id: UBERON:0007271
name: appendage musculature
def: "Any collection of muscles that is part of an appendage." []
synonym: "fin musculature" NARROW []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0000026 ! appendage
relationship: part_of UBERON:0000026 ! appendage

[Term]
id: UBERON:0007272
name: pectoral appendage skeleton
def: "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." []
synonym: "cheiropterygium" RELATED []
is_a: UBERON:0011582 ! paired limb/fin skeleton
relationship: part_of UBERON:0004710 ! pectoral appendage

[Term]
id: UBERON:0007273
name: pelvic appendage skeleton
def: "The collection of all skeletal elements in a pelvic appendage region." []
is_a: UBERON:0011582 ! paired limb/fin skeleton
relationship: part_of UBERON:0004709 ! pelvic appendage

[Term]
id: UBERON:0007298
name: pronephric proximal convoluted tubule
def: "A proximal convoluted tubule that is part of a pronephros." []
is_a: UBERON:0001287 ! proximal convoluted tubule
is_a: UBERON:0005310 ! pronephric nephron tubule
intersection_of: UBERON:0001287 ! proximal convoluted tubule
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0005309 ! pronephric nephron

[Term]
id: UBERON:0007300
name: pectoral appendage blood vessel
def: "A blood vessel that is part of a pectoral appendage." []
synonym: "pectoral fin blood vessel" NARROW []
is_a: UBERON:0007301 ! appendage blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage

[Term]
id: UBERON:0007301
name: appendage blood vessel
def: "A blood vessel that is part of a limb/fin." []
synonym: "fin blood vessel" NARROW []
synonym: "limb blood vessel" NARROW []
is_a: UBERON:0001981 ! blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0000026 ! appendage
relationship: part_of UBERON:0000026 ! appendage
relationship: part_of UBERON:0007304 ! appendage vasculature

[Term]
id: UBERON:0007302
name: pectoral appendage vasculature
def: "A vasculature that is part of a pectoral appendage." []
synonym: "pectoral fin vasculature" NARROW []
is_a: UBERON:0007304 ! appendage vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage

[Term]
id: UBERON:0007303
name: pharyngeal vasculature
def: "A vasculature that is part of a chordate pharynx." []
synonym: "branchial vasculature" EXACT []
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0007304
name: appendage vasculature
def: "A vasculature that is part of a limb/fin." []
synonym: "fin vasculature" NARROW []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000026 ! appendage
relationship: part_of UBERON:0000026 ! appendage

[Term]
id: UBERON:0007306
name: pronephric glomerular capillary
def: "A glomerular capillary that is part of a pronephros." []
is_a: UBERON:0004212 ! glomerular capillary
intersection_of: UBERON:0004212 ! glomerular capillary
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0004739 ! pronephric glomerulus
relationship: part_of UBERON:0005309 ! pronephric nephron

[Term]
id: UBERON:0007307
name: pronephric glomerular basement membrane
def: "A glomerular basement membrane that is part of a pronephros." []
synonym: "pronephric glomerular filtration membrane" EXACT []
is_a: UBERON:0005777 ! glomerular basement membrane
intersection_of: UBERON:0005777 ! glomerular basement membrane
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0004739 ! pronephric glomerulus

[Term]
id: UBERON:0007324
name: pancreatic lobule
def: "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." []
synonym: "lobulus pancreaticus" EXACT []
synonym: "pancreas lobe" EXACT []
synonym: "pancreatic lobule" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: has_part UBERON:0001263 ! pancreatic acinus
relationship: has_part UBERON:0014719 ! intralobular duct
relationship: part_of UBERON:0000017 ! exocrine pancreas

[Term]
id: UBERON:0007329
name: pancreatic duct
def: "A duct that is part of the pancreas and connected to the duodenum." []
synonym: "duct of pancreas" EXACT []
synonym: "ductus pancreaticus" RELATED []
synonym: "pancreas duct" EXACT []
is_a: UBERON:0003928 ! digestive system duct
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: develops_from UBERON:0003922 ! pancreatic epithelial bud
relationship: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0007352
name: stria vascularis vasculature
def: "blood vessels supplying the stria vascularis in the cochlea of the inner ear." []
synonym: "stria vascularis blood vessel" RELATED []
synonym: "stria vascularis blood vessels" EXACT []
is_a: UBERON:0002200 ! vasculature of head
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct
relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct

[Term]
id: UBERON:0007376
name: outer epithelium
def: "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." []
synonym: "epidermis" EXACT []
synonym: "epidermis (sensu Metazoa)" EXACT []
synonym: "hypoderm" RELATED []
synonym: "hypodermis" RELATED []
synonym: "outer epidermal layer" EXACT []
synonym: "outer epithelial layer" EXACT []
is_a: UBERON:0003102 ! surface structure
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0007383 ! enveloping layer of ectoderm

[Term]
id: UBERON:0007383
name: enveloping layer of ectoderm
def: "Outermost layer of cells surrounding the embryo." []
synonym: "enveloping layer" EXACT []
synonym: "EVL" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm

[Term]
id: UBERON:0007384
name: appendage lymph vessel
def: "A lymphatic vessel that is part of a limb/fin." []
is_a: UBERON:0001473 ! lymphatic vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0004708 ! paired limb/fin
relationship: part_of UBERON:0004708 ! paired limb/fin
relationship: part_of UBERON:0007304 ! appendage vasculature

[Term]
id: UBERON:0007385
name: pectoral appendage lymph vessel
def: "A lymphatic vessel that is part of a pectoral appendage." []
is_a: UBERON:0007384 ! appendage lymph vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0007302 ! pectoral appendage vasculature

[Term]
id: UBERON:0007386
name: pelvic appendage lymph vessel
def: "A lymphatic vessel that is part of a pelvic appendage." []
is_a: UBERON:0007384 ! appendage lymph vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0004709 ! pelvic appendage

[Term]
id: UBERON:0007389
name: paired limb/fin cartilage
def: "A cartilage tissue that is part of a paired limb or fin." []
is_a: UBERON:0002418 ! cartilage tissue
intersection_of: UBERON:0002418 ! cartilage tissue
intersection_of: part_of UBERON:0004708 ! paired limb/fin
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0004708 ! paired limb/fin

[Term]
id: UBERON:0007390
name: pectoral appendage cartilage tissue
def: "A cartilage tissue that is part of a pectoral appendage." []
synonym: "pectoral fin cartilage" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0007389 ! paired limb/fin cartilage
intersection_of: UBERON:0002418 ! cartilage tissue
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0007272 ! pectoral appendage skeleton

[Term]
id: UBERON:0007391
name: pelvic appendage cartilage tissue
def: "A cartilage tissue that is part of a pelvic appendage." []
synonym: "pelvic fin cartilage" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0007389 ! paired limb/fin cartilage
intersection_of: UBERON:0002418 ! cartilage tissue
intersection_of: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0007273 ! pelvic appendage skeleton

[Term]
id: UBERON:0007414
name: nucleus of midbrain tegmentum
def: "A nucleus of brain that spans a midbrain tegmentum." []
synonym: "tegmental nuclei" EXACT []
synonym: "tegmental nucleus" EXACT []
is_a: UBERON:0000125 ! neural nucleus

[Term]
id: UBERON:0007475
name: matrix-based tissue
def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." []
is_a: UBERON:0000479 ! tissue

[Term]
id: UBERON:0007499
name: epithelial sac
def: "An epithelial tube that is open at one end only." []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0009856 ! sac

[Term]
id: UBERON:0007500
name: epithelial tube open at both ends
def: "An epithelial tube open at both ends that allows fluid flow." []
is_a: UBERON:0003914 ! epithelial tube

[Term]
id: UBERON:0007501
name: arborizing epithelial duct system
def: "A collection of connected epithelial tubes with a single portal." []
synonym: "arborising epithelial duct system" EXACT []
is_a: UBERON:0007499 ! epithelial sac
relationship: has_part UBERON:0003914 ! epithelial tube

[Term]
id: UBERON:0007503
name: epithelial vesicle
def: "A closed epithelium with a lumen." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0007521
name: smooth muscle sphincter
def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." []
is_a: UBERON:0004590 ! sphincter muscle

[Term]
id: UBERON:0007524
name: dense mesenchyme tissue
def: "Mesenchyme with little extracellular matrix." []
is_a: UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0007530
name: migrating mesenchyme population
def: "Mesenchymal cells that are migrating." []
is_a: UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0007589
name: ciliated columnar oviduct epithelium
def: "A ciliated columnar epithelium that is part of a oviduct." []
synonym: "epithelium of uterine tube" RELATED []
synonym: "uterine tube epithelium" RELATED []
is_a: UBERON:0004804 ! oviduct epithelium
is_a: UBERON:0007592 ! ciliated columnar epithelium
intersection_of: UBERON:0007592 ! ciliated columnar epithelium
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0000993 ! oviduct

[Term]
id: UBERON:0007590
name: cuboidal oviduct epithelium
def: "A cuboidal epithelium that is part of a oviduct." []
is_a: UBERON:0004804 ! oviduct epithelium
is_a: UBERON:0010077 ! cuboidal epithelium
intersection_of: UBERON:0010077 ! cuboidal epithelium
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0000993 ! oviduct

[Term]
id: UBERON:0007592
name: ciliated columnar epithelium
def: "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]" []
is_a: UBERON:0000485 ! simple columnar epithelium
is_a: UBERON:0007601 ! ciliated epithelium

[Term]
id: UBERON:0007601
name: ciliated epithelium
def: "Epithelium bearing vibratile cilia on the free surface." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0007602
name: stratified columnar epithelium
def: "Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP]" []
synonym: "epithelium stratificatum columnare" EXACT []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0012274 ! columnar epithelium

[Term]
id: UBERON:0007616
name: layer of synovial tissue
def: "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." []
synonym: "stratum synoviale" NARROW []
synonym: "synovial layer" NARROW []
synonym: "synovial membrane" NARROW []
synonym: "synovial tissue" RELATED []
synonym: "synovium" EXACT []
is_a: UBERON:0000042 ! serous membrane

[Term]
id: UBERON:0007625
name: pigment epithelium of eye
def: "epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." []
synonym: "eye pigment epithelium" RELATED []
is_a: UBERON:0019304 ! sensory organ epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye

[Term]
id: UBERON:0007635
name: nucleus of medulla oblongata
def: "A neural nucleus that is part of a medulla oblongata." []
is_a: UBERON:0006331 ! brainstem nucleus
is_a: UBERON:0009662 ! hindbrain nucleus
intersection_of: UBERON:0000125 ! neural nucleus
intersection_of: part_of UBERON:0001896 ! medulla oblongata
relationship: part_of UBERON:0001896 ! medulla oblongata

[Term]
id: UBERON:0007644
name: thoracic lymph node
def: "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes" []
synonym: "deep thoracic lymph node" RELATED []
synonym: "lymph node of thorax" EXACT []
is_a: UBERON:0000029 ! lymph node
is_a: UBERON:0005181 ! thoracic segment organ
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0007651
name: anatomical junction
def: "An anatomical structure that connects two structures" []
synonym: "anatomical junction" EXACT []
synonym: "junction" BROAD []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0007652
name: esophageal sphincter
def: "A sphincter that is part of an esophagus." []
is_a: UBERON:0003832 ! esophagus muscle
is_a: UBERON:0004590 ! sphincter muscle
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0007684
name: uriniferous tubule
def: "functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0006555 ! excretory tube
relationship: has_part UBERON:0001232 ! collecting duct of renal tubule
relationship: has_part UBERON:0001285 ! nephron
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0007685
name: region of nephron tubule
synonym: "region of renal tubule" RELATED []
synonym: "renal tubule region" EXACT []
is_a: UBERON:0001231 ! nephron tubule
is_a: UBERON:0004810 ! nephron tubule epithelium
relationship: part_of UBERON:0001231 ! nephron tubule

[Term]
id: UBERON:0007687
name: kidney field
def: "region of the embryo into the area in which the kidney rudiment will develop." []
synonym: "kidney anlage" RELATED []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0007688 ! anlage
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0007688
name: anlage
def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." []
synonym: "developmental field" EXACT []
synonym: "field" BROAD []
synonym: "future organ" RELATED []
synonym: "organ field" RELATED []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0007690
name: early pharyngeal endoderm
def: "." []
synonym: "early pharyngeal arch endoderm" EXACT []
synonym: "pharyngeal arch endoderm" RELATED []
synonym: "pharyngeal endoderm" RELATED []
synonym: "pharyngeal region endoderm" RELATED []
is_a: UBERON:0003258 ! endoderm of foregut
is_a: UBERON:0004814 ! upper respiratory tract epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0008814 ! pharyngeal arch system
relationship: part_of UBERON:0009722 ! entire pharyngeal arch endoderm

[Term]
id: UBERON:0007692
name: nucleus of thalamus
def: "A nucleus of brain that is part of a thalamus." []
synonym: "nuclear complex of thalamus" RELATED []
synonym: "thalamic nucleus" EXACT []
is_a: UBERON:0006569 ! diencephalic nucleus
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0001897 ! dorsal plus ventral thalamus
relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus

[Term]
id: UBERON:0007719
name: bone of reproductive organ
def: "A bone that is part of a reproductive organ." []
synonym: "baculum" NARROW []
synonym: "os penis/os clitoris" RELATED []
is_a: UBERON:0001474 ! bone element
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0003133 ! reproductive organ
relationship: part_of UBERON:0003133 ! reproductive organ

[Term]
id: UBERON:0007771
name: epidermis gland
def: "A gland that is part of a epidermis." []
synonym: "epidermal gland" EXACT []
synonym: "gland of epidermis" EXACT []
is_a: UBERON:0002419 ! skin gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: UBERON:0007777
name: umbilical vein endothelium
def: "An endothelium that is part of a umbilical vein." []
is_a: UBERON:0001919 ! endothelium of vein
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0002066 ! umbilical vein
relationship: part_of UBERON:0002066 ! umbilical vein

[Term]
id: UBERON:0007778
name: umbilical artery endothelium
def: "An endothelium that is part of a umbilical artery." []
is_a: UBERON:0001917 ! endothelium of artery
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: part_of UBERON:0001310 ! umbilical artery

[Term]
id: UBERON:0007798
name: vascular system
def: "Anatomical system that consists of all blood and lymph vessels." []
synonym: "Gefaesssystem@ge" RELATED []
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0007806
name: connecting stalk
def: "A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord." []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm

[Term]
id: UBERON:0007807
name: connecting stalk vasculature
def: "A vasculature that is part of a connecting stalk." []
synonym: "connecting stalk blood vessel" RELATED []
synonym: "connecting stalk blood vessels" EXACT []
synonym: "vasculature of connecting stalk" RELATED []
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0007806 ! connecting stalk
relationship: develops_from UBERON:0011921 ! connecting stalk blood islands
relationship: part_of UBERON:0007806 ! connecting stalk

[Term]
id: UBERON:0007808
name: adipose tissue of abdominal region
def: "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." []
synonym: "abdominal adipose tissue" RELATED []
synonym: "abdominal fat" RELATED []
synonym: "intra-abdominal fat" RELATED []
is_a: UBERON:0001013 ! adipose tissue
is_a: UBERON:0003567 ! abdomen connective tissue
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0007811
name: craniocervical region
def: "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." []
synonym: "cephalic area" RELATED []
synonym: "cephalic part of animal" RELATED []
synonym: "cephalic region" RELATED []
synonym: "head and neck" RELATED []
synonym: "head or neck" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0000033 ! head
relationship: has_part UBERON:0006562 ! pharynx
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: part_of UBERON:0013702 ! body proper

[Term]
id: UBERON:0007823
name: appendage girdle region
def: "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." []
synonym: "fin girdle" RELATED []
synonym: "fin girdle region" RELATED []
synonym: "girdle" BROAD []
synonym: "girdle region" BROAD []
synonym: "limb girdle" RELATED []
synonym: "limb girdle region" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0010707 ! appendage girdle complex

[Term]
id: UBERON:0007826
name: peritoneal mesentery
def: "Mesentery that is located in the peritoneum." []
is_a: UBERON:0002095 ! mesentery
is_a: UBERON:0002358 ! peritoneum
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0001178 ! visceral peritoneum
relationship: part_of UBERON:0002358 ! peritoneum

[Term]
id: UBERON:0007828
name: girdle bone/zone
def: "A bone that is part of a appendage girdle region." []
synonym: "girdle bone" EXACT []
is_a: UBERON:0010740 ! bone of appendage girdle complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0007823 ! appendage girdle region
relationship: part_of UBERON:0007823 ! appendage girdle region
relationship: part_of UBERON:0010719 ! girdle skeleton

[Term]
id: UBERON:0007829
name: pectoral girdle bone
def: "A bone that is part of a pectoral girdle region." []
synonym: "bone of pectoral girdle" EXACT []
is_a: UBERON:0007828 ! girdle bone/zone
is_a: UBERON:0010741 ! bone of pectoral complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0007831 ! pectoral girdle skeleton

[Term]
id: UBERON:0007830
name: pelvic girdle bone/zone
def: "A bone element or fused bone that is part of pelvic girdle." []
synonym: "bone of pelvic girdle" EXACT []
synonym: "pelvic girdle bone" EXACT []
is_a: UBERON:0003828 ! abdominal segment bone
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005179 ! pelvic region element
is_a: UBERON:0005913 ! zone of bone organ
is_a: UBERON:0007828 ! girdle bone/zone
is_a: UBERON:0010742 ! bone of pelvic complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0007832 ! pelvic girdle skeleton

[Term]
id: UBERON:0007831
name: pectoral girdle skeleton
def: "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." []
synonym: "cingulum pectorale" RELATED []
synonym: "pectoral girdle" RELATED []
synonym: "scapular girdle" RELATED []
synonym: "skeletal parts of pectoral girdle" EXACT []
synonym: "skeleton of pectoral girdle" EXACT []
is_a: UBERON:0010719 ! girdle skeleton
relationship: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0012475 ! skeleton of pectoral complex

[Term]
id: UBERON:0007832
name: pelvic girdle skeleton
def: "Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature." []
synonym: "pelvic girdle" RELATED []
synonym: "pelvic girdle skeleton" EXACT []
synonym: "skeletal parts of pelvic girdle" EXACT []
synonym: "skeleton of pelvic girdle" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010719 ! girdle skeleton
relationship: develops_from UBERON:0010377 ! mesenchyme from somatopleure
relationship: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0012476 ! skeleton of pelvic complex

[Term]
id: UBERON:0007842
name: membrane bone
def: "Bone element that arises as a result of intramembranous ossification." []
synonym: "membrane bones" RELATED []
is_a: UBERON:0001474 ! bone element

[Term]
id: UBERON:0007844
name: cartilage element
def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." []
synonym: "cartilage" RELATED []
synonym: "cartilage organ" EXACT []
synonym: "cartilaginous element" EXACT []
synonym: "chondrogenic element" EXACT []
is_a: UBERON:0004765 ! skeletal element
relationship: develops_from UBERON:0005863 ! cartilaginous condensation
relationship: has_part UBERON:0002418 ! cartilage tissue

[Term]
id: UBERON:0007845
name: regular connective tissue
def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." []
is_a: UBERON:0002384 ! connective tissue
disjoint_from: UBERON:0011821 ! irregular connective tissue
relationship: has_part UBERON:0011860 ! collection of collagen fibrils

[Term]
id: UBERON:0007846
name: dense regular connective tissue
def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." []
synonym: "dense fibrous connective tissue" EXACT []
synonym: "dense regular collagenous connective tissue" EXACT []
synonym: "dense regular collagenous tissue" EXACT []
synonym: "regular dense connective tissue" EXACT []
synonym: "typus regularis (textus connectivus collagenosus compactus)" EXACT []
is_a: UBERON:0007845 ! regular connective tissue
is_a: UBERON:0011823 ! dense connective tissue

[Term]
id: UBERON:0007914
name: bone of craniocervical region
def: "A bone that is part of a craniocervical region." []
synonym: "cranial bone" RELATED []
synonym: "head or neck bone" EXACT []
is_a: UBERON:0001474 ! bone element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0007811 ! craniocervical region

[Term]
id: UBERON:0008001
name: irregular bone
def: "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." []
synonym: "os irregulare" EXACT []
synonym: "os irregulare" RELATED []
is_a: UBERON:0001474 ! bone element

[Term]
id: UBERON:0008114
name: joint of girdle
def: "A skeletal joint that is part of a appendage girdle region." []
synonym: "girdle joint" EXACT []
is_a: UBERON:0000982 ! skeletal joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0007823 ! appendage girdle region
relationship: part_of UBERON:0007823 ! appendage girdle region

[Term]
id: UBERON:0008193
name: pneumatized bone
def: "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." []
synonym: "hollow bone" RELATED []
synonym: "os pneumaticum" EXACT []
synonym: "pneumatic bone" EXACT []
is_a: UBERON:0001474 ! bone element
intersection_of: UBERON:0001474 ! bone element
intersection_of: has_part UBERON:0010528 ! pneumatic cavity of bone
relationship: has_part UBERON:0010528 ! pneumatic cavity of bone

[Term]
id: UBERON:0008196
name: muscle of pectoral girdle
def: "Any muscle organ that is part of a pectoral girdle region." []
synonym: "muscle of shoulder girdle" EXACT []
synonym: "pectoral girdle muscle" EXACT []
is_a: UBERON:0010891 ! pectoral complex muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0004471 ! musculature of pectoral girdle

[Term]
id: UBERON:0008202
name: bone of hip region
is_a: UBERON:0001474 ! bone element

[Term]
id: UBERON:0008229
name: craniocervical region musculature
def: "Musculature system of the pharyngeal and head regions." []
synonym: "head muscles" RELATED []
synonym: "head or neck muscle" EXACT []
synonym: "head or neck muscle" RELATED []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0007811 ! craniocervical region

[Term]
id: UBERON:0008266
name: periodontal ligament
def: "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]." []
synonym: "alveolar periosteum" RELATED []
synonym: "alveolodental ligament" RELATED []
synonym: "alveolodental membrane" RELATED []
synonym: "desmodontium" RELATED []
synonym: "fibra periodontalis" EXACT []
synonym: "odontoperiosteum" RELATED []
synonym: "paradentium" RELATED []
synonym: "PDL" RELATED []
synonym: "peridental membrane" RELATED []
synonym: "peridontal fiber" RELATED []
synonym: "peridontal fibre" RELATED []
synonym: "peridontal ligament" RELATED []
synonym: "peridontal ligament fiber" RELATED []
synonym: "peridontal ligament fibre" RELATED []
synonym: "peridontal membrane" RELATED []
synonym: "peridontium" RELATED []
synonym: "periodontal fiber" EXACT []
synonym: "periodontal fibre" EXACT []
is_a: UBERON:0008846 ! skeletal ligament
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0000211 ! ligament
intersection_of: part_of UBERON:0001758 ! periodontium
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0008969 ! dental follicle
relationship: part_of UBERON:0001758 ! periodontium

[Term]
id: UBERON:0008307
name: heart endothelium
def: "An endothelium that is part of a heart [Automatically generated definition]." []
synonym: "cardiac endothelium" RELATED []
is_a: UBERON:0004852 ! cardiovascular system endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0008310
name: nasopharyngeal gland
def: "A gland that is part of a nasopharynx." []
is_a: UBERON:0003295 ! pharyngeal gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx

[Term]
id: UBERON:0008339
name: microvascular endothelium
is_a: UBERON:0004852 ! cardiovascular system endothelium

[Term]
id: UBERON:0008342
name: intestinal villus of duodenum
def: "An intestinal villus in the duodenum." []
is_a: UBERON:0001213 ! intestinal villus
intersection_of: UBERON:0001213 ! intestinal villus
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0000320 ! duodenal mucosa
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0008343
name: intestinal villus of jejunum
def: "An intestinal villus in the jejunum." []
is_a: UBERON:0001213 ! intestinal villus
intersection_of: UBERON:0001213 ! intestinal villus
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0000399 ! jejunal mucosa
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0008344
name: intestinal villus of ileum
def: "An intestinal villus in the ileum." []
is_a: UBERON:0001213 ! intestinal villus
intersection_of: UBERON:0001213 ! intestinal villus
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0000331 ! ileal mucosa
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: UBERON:0008345
name: ileal epithelium
def: "An epithelium that is part of a ileum." []
synonym: "epithelium of ileum" EXACT []
is_a: UBERON:0013636 ! epithelium of intestinal villus
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0008344 ! intestinal villus of ileum

[Term]
id: UBERON:0008346
name: duodenal epithelium
def: "An epithelium that is part of a duodenum." []
synonym: "epithelium of duodenum" EXACT []
is_a: UBERON:0013636 ! epithelium of intestinal villus
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008342 ! intestinal villus of duodenum

[Term]
id: UBERON:0008367
name: breast epithelium
def: "An epithelium that is part of a breast." []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000310 ! breast
relationship: part_of UBERON:0000310 ! breast

[Term]
id: UBERON:0008404
name: proximale tubular epithelium
def: "The cells lining the proximal tubule are cuboidal epithelial cells with deep basal membrane invaginations that provide a large basal surface area. The long microvilli (the brush border) lining the tubule lumen, maximize luminal surface area and make these cells ideally suited for both reabsorptive and secretory functions." []
synonym: "proximale tubule epithelium" RELATED []
is_a: UBERON:0004810 ! nephron tubule epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004134 ! proximal tubule
relationship: part_of UBERON:0004134 ! proximal tubule

[Term]
id: UBERON:0008408
name: distal tubular epithelium
def: "An epithelium that is part of a distal tubule." []
synonym: "distal tubule epithelium" RELATED []
is_a: UBERON:0004810 ! nephron tubule epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004135 ! distal tubule
relationship: part_of UBERON:0004135 ! distal tubule

[Term]
id: UBERON:0008522
name: nasal muscle
def: "Any muscle organ that is part of an nose." []
synonym: "muscle of nose" EXACT []
is_a: UBERON:0000078 ! mixed ectoderm/mesoderm/endoderm-derived structure
is_a: UBERON:0001577 ! facial muscle
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0000004 ! nose

[Term]
id: UBERON:0008713
name: pectoral girdle and thoracic body wall skeletal muscle
is_a: UBERON:0001134 ! skeletal muscle tissue

[Term]
id: UBERON:0008715
name: muscle tissue of prostate
def: "A muscle tissue that is part of a prostate gland." []
synonym: "prostate gland muscle tissue" EXACT []
synonym: "prostate muscle tissue" EXACT []
synonym: "prostatic muscle" EXACT []
synonym: "prostatic musclular tissue" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0002385 ! muscle tissue
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0002385 ! muscle tissue
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0008780
name: inner cell mass derived epiblast
def: "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers" []
synonym: "embryonic epiblast" RELATED []
is_a: UBERON:0002532 ! epiblast (generic)
intersection_of: UBERON:0002532 ! epiblast (generic)
intersection_of: develops_from UBERON:0000087 ! inner cell mass
relationship: develops_from UBERON:0000087 ! inner cell mass
relationship: part_of UBERON:0000091 ! bilaminar disc

[Term]
id: UBERON:0008784
name: lower limb segment
def: "A limb segment that is part of a hindlimb." []
synonym: "free lower limb segment" EXACT []
synonym: "free lower limb subdivision" EXACT []
synonym: "segment of free lower limb" EXACT []
synonym: "subdivision of free lower limb" EXACT []
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0008785
name: upper limb segment
def: "A limb segment that is part of a forelimb." []
synonym: "free upper limb segment" EXACT []
synonym: "free upper limb subdivision" EXACT []
synonym: "segment of free upper limb" EXACT []
synonym: "subdivision of free upper limb" EXACT []
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0008811
name: intromittent organ
def: "An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]." []
synonym: "aedeagus" NARROW []
synonym: "copulatory organ" RELATED []
synonym: "penis" NARROW []
is_a: UBERON:0003135 ! male reproductive organ
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0008814
name: pharyngeal arch system
def: "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." []
synonym: "pharyngeal apparatus" EXACT []
synonym: "pharyngeal arch region" EXACT []
synonym: "pharyngeal arches and clefts" RELATED []
synonym: "pharyngeal system" EXACT []
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0009145 ! pharyngeal region of foregut

[Term]
id: UBERON:0008816
name: embryonic head
def: "A head that is part of a embryo." []
is_a: UBERON:0000033 ! head
is_a: UBERON:0002050 ! embryonic structure
intersection_of: UBERON:0000033 ! head
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0008817
name: thymus primordium endoderm
def: "An endoderm that is part of a thymus primordium." []
is_a: UBERON:0000925 ! endoderm
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0005562 ! thymus primordium
relationship: part_of UBERON:0005562 ! thymus primordium

[Term]
id: UBERON:0008823
name: neural tube derived brain
def: "A brain that develops_from a neural tube." []
synonym: "vertebrate brain" NARROW []
is_a: UBERON:0000489 ! cavitated compound organ
is_a: UBERON:0000955 ! brain
intersection_of: UBERON:0000955 ! brain
intersection_of: develops_from UBERON:0001049 ! neural tube
relationship: develops_from UBERON:0001049 ! neural tube
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0008835
name: hepatic diverticulum
def: "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." []
synonym: "diverticulum hepaticum" RELATED []
synonym: "liver diverticulum" EXACT []
is_a: UBERON:0004185 ! endodermal part of digestive tract
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0003894 ! liver primordium
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004161 ! septum transversum
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0008836
name: liver bud
is_a: UBERON:0004185 ! endodermal part of digestive tract
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0008835 ! hepatic diverticulum
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0008845
name: nonskeletal ligament
def: "A ligament that does not connect two skeletal elements." []
synonym: "fibrous ligament" RELATED []
synonym: "non-skeletal ligament" EXACT []
is_a: UBERON:0000211 ! ligament
disjoint_from: UBERON:0008846 ! skeletal ligament

[Term]
id: UBERON:0008846
name: skeletal ligament
def: "Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified]." []
synonym: "articular larua" EXACT []
synonym: "articular ligament" EXACT []
synonym: "ligament" BROAD []
synonym: "true ligament" EXACT []
is_a: UBERON:0000211 ! ligament
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0008856
name: stomach muscularis externa
def: "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" []
synonym: "gastric muscularis" EXACT []
synonym: "muscle layer of stomach" EXACT []
synonym: "muscularis externa of stomach" EXACT []
synonym: "tunica muscularis (gaster)" EXACT []
synonym: "tunica muscularis gastris" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0009034 ! stomach region
is_a: UBERON:0018261 ! muscular coat of digestive tract
is_a: UBERON:0034933 ! layer of smooth muscle tissue
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001167 ! wall of stomach
relationship: part_of UBERON:0001167 ! wall of stomach
relationship: part_of UBERON:0004222 ! stomach smooth muscle

[Term]
id: UBERON:0008858
name: pyloric canal
def: "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter" []
synonym: "canalis pyloricus" EXACT []
synonym: "canalis pyloricus" RELATED []
is_a: UBERON:0009870 ! zone of stomach
relationship: part_of UBERON:0001166 ! pylorus

[Term]
id: UBERON:0008859
name: cardiac gastric gland
def: "A gastric gland in the cardiac region of the stomach; cardiac glands are fewer in number than in the fundus and body, and secrete mucin which coats the stomach and protects it[MP]" []
synonym: "cardiac gland" RELATED []
synonym: "gardiac gland" EXACT []
synonym: "gastric cardiac gland" EXACT []
synonym: "gastric cardiac mucuous gland" EXACT []
synonym: "gastric gland of cardia" EXACT []
synonym: "glandula cardiaca (gaster)" EXACT []
is_a: UBERON:0000325 ! gastric gland
is_a: UBERON:0000414 ! mucous gland
intersection_of: UBERON:0000325 ! gastric gland
intersection_of: part_of UBERON:0001162 ! cardia of stomach
relationship: part_of UBERON:0001162 ! cardia of stomach
relationship: part_of UBERON:0004996 ! mucosa of cardia of stomach

[Term]
id: UBERON:0008861
name: pyloric gastric gland
def: "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." []
synonym: "glandula pylorica" EXACT []
synonym: "pyloric antrum gland" EXACT []
synonym: "pyloric gland" EXACT []
synonym: "pyloric mucuous gland" EXACT []
is_a: UBERON:0000325 ! gastric gland
is_a: UBERON:0000414 ! mucous gland
intersection_of: UBERON:0000325 ! gastric gland
intersection_of: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0004998 ! mucosa of pylorus

[Term]
id: UBERON:0008870
name: pulmonary alveolar parenchyma
def: "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" []
is_a: UBERON:0008946 ! lung parenchyma
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002299 ! alveolus of lung
relationship: part_of UBERON:0002299 ! alveolus of lung

[Term]
id: UBERON:0008874
name: pulmonary acinus
def: "The part of the airway consisting of a respiratory bronchiole and all of its branches" []
synonym: "acinus pulmonaris" EXACT []
synonym: "arbor alveolaris" EXACT []
synonym: "lobulus pulmonis primarius" EXACT []
synonym: "primary pulmonary lobule" EXACT []
synonym: "respiratory lobule" EXACT []
is_a: UBERON:0010368 ! pulmonary lobule

[Term]
id: UBERON:0008876
name: hypodermis skeletal muscle layer
def: "Any skeletal muscle organ in the hypodermis / superficial fascia" []
synonym: "hypodermal muscle layer" EXACT []
synonym: "hypodermis muscle layer" EXACT []
synonym: "panniculus carnosus" NARROW []
synonym: "superficial fascia muscular layer" EXACT []
is_a: UBERON:0004253 ! skin muscle
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0008877
name: epidermal-dermal junction
def: "The multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" []
synonym: "dermal-epidermal junction" EXACT []
synonym: "dermo-epidermal junction" EXACT []
synonym: "dermoepidermal junction" EXACT []
synonym: "epidermal dermol junction" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005769 ! basement membrane of epithelium
relationship: part_of UBERON:0000014 ! zone of skin

[Term]
id: UBERON:0008883
name: osteoid
def: "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." []
synonym: "osteoid tissue" EXACT []
synonym: "pre-bone" EXACT []
synonym: "prebone" EXACT []
synonym: "prebone tissue" EXACT []
is_a: UBERON:0002481 ! bone tissue
is_a: UBERON:0007475 ! matrix-based tissue

[Term]
id: UBERON:0008886
name: pulmonary vascular system
def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." []
synonym: "pulmonary circulatory system" EXACT []
synonym: "pulmonary system" EXACT []
is_a: UBERON:0007798 ! vascular system
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0002012 ! pulmonary artery
relationship: has_part UBERON:0002016 ! pulmonary vein
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0008895
name: splanchnocranium
def: "Subdivision of endoskeleton derived from pharyngeal arches" []
synonym: "branchial arch skeleton" RELATED []
synonym: "gill arch skeleton" RELATED []
synonym: "pharyngeal arch" RELATED []
synonym: "pharyngeal arch skeleton" RELATED []
synonym: "pharyngeal endoskeleton" EXACT []
synonym: "pharyngeal skeleton" RELATED []
synonym: "visceral cranium" RELATED []
synonym: "visceral skeletal system" RELATED []
synonym: "visceral skeleton" RELATED []
synonym: "viscerocranium" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system
disjoint_from: UBERON:0011156 ! facial skeleton
relationship: develops_from UBERON:0002539 ! pharyngeal arch

[Term]
id: UBERON:0008904
name: neuromast
def: "Volcano-shaped lateral line sensory organ located in characteristic positions within the skin epithelium and containing hair cells and their support elements." []
synonym: "cyatocïde@fr" EXACT []
synonym: "lateral line neuromast" EXACT []
synonym: "lateral line organ" BROAD []
synonym: "neuromast organ" EXACT []
synonym: "neuromaste superficiel@fr" EXACT []
synonym: "neuromasts" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0035555 ! lateral line sense organ
relationship: develops_from UBERON:0009128 ! lateral line placode
relationship: part_of UBERON:0010202 ! lateral line

[Term]
id: UBERON:0008906
name: lateral line nerve
def: "Cranial nerves that carry afferent and efferent fibers for the lateral line system." []
synonym: "lateral line nerves" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0001785 ! cranial nerve
relationship: develops_from UBERON:0009128 ! lateral line placode
relationship: part_of UBERON:0002540 ! lateral line system

[Term]
id: UBERON:0008907
name: dermal bone
def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." []
synonym: "dermal bones" RELATED []
is_a: UBERON:0004756 ! dermal skeletal element
is_a: UBERON:0007842 ! membrane bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0010364 ! dermal skeleton
relationship: part_of UBERON:0010364 ! dermal skeleton

[Term]
id: UBERON:0008946
name: lung parenchyma
def: "A parenchyma that is part of a lung." []
synonym: "parenchyma of lung" RELATED []
synonym: "pulmonary parenchyma" RELATED []
synonym: "respiratory portion of lung" EXACT []
is_a: UBERON:0000353 ! parenchyma
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0008947
name: respiratory primordium
is_a: UBERON:0001048 ! primordium
relationship: part_of UBERON:0003258 ! endoderm of foregut

[Term]
id: UBERON:0008962
name: forelimb bone
def: "A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder." []
synonym: "free forelimb bone" EXACT []
synonym: "wing bone" NARROW []
is_a: UBERON:0002428 ! limb bone
is_a: UBERON:0010741 ! bone of pectoral complex
is_a: UBERON:0015021 ! forelimb endochondral element
relationship: develops_from UBERON:0010883 ! forelimb cartilage element

[Term]
id: UBERON:0008969
name: dental follicle
def: "The dental follicle is a sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively." []
synonym: "dental sac" RELATED []
synonym: "tooth follicle" RELATED []
is_a: UBERON:0005087 ! tooth placode
relationship: develops_from UBERON:0002342 ! neural crest

[Term]
id: UBERON:0008987
name: renal parenchyma
def: "The functional tissue of the kidney, consisting of the nephrons." []
synonym: "kidney parenchyma" RELATED []
synonym: "parenchyma of kidney" EXACT []
is_a: UBERON:0000353 ! parenchyma
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0008989
name: submocosal esophageal gland
def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." []
synonym: "esophageal gland" EXACT []
synonym: "glandulae oesophageae" EXACT []
synonym: "mucous gland of submucosa of esophagus" EXACT []
is_a: UBERON:0003408 ! gland of gut
is_a: UBERON:0005181 ! thoracic segment organ
is_a: UBERON:0011148 ! submucosal gland
intersection_of: UBERON:0011148 ! submucosal gland
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0008998
name: vasculature of brain
def: "System pertaining to blood vessels in the brain." []
synonym: "brain vasculature" EXACT []
synonym: "cerebrovascular system" EXACT []
synonym: "intracerebral vasculature" EXACT []
is_a: UBERON:0006876 ! vasculature of organ
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0009034
name: stomach region
def: "An organ part that is part of a stomach." []
is_a: UBERON:0000064 ! organ part
intersection_of: UBERON:0000064 ! organ part
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: UBERON:0009035
name: renal straight tubule
def: "Any region of a nephron tubule that is straight. Examples: distal convoluted tubule, proximal convoluted tuble." []
synonym: "kidney straight tubule" EXACT []
synonym: "straight tubule" EXACT []
is_a: UBERON:0007685 ! region of nephron tubule

[Term]
id: UBERON:0009039
name: lymph node germinal center
def: "A germinal center that is located in a lymph node" []
synonym: "germinal center" BROAD []
synonym: "lymph node activated zone" RELATED []
synonym: "lymph node central zone" RELATED []
synonym: "lymph node light zone" RELATED []
synonym: "lymph node nodule" RELATED []
is_a: UBERON:0010754 ! germinal center
intersection_of: UBERON:0010754 ! germinal center
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0010753 ! lymph node secondary follicle

[Term]
id: UBERON:0009089
name: inner medulla vasa recta descending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta

[Term]
id: UBERON:0009090
name: outer medulla vasa recta descending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta

[Term]
id: UBERON:0009091
name: vasa recta ascending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004726 ! vasa recta

[Term]
id: UBERON:0009092
name: inner medulla vasa recta ascending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta

[Term]
id: UBERON:0009093
name: outer medulla vasa recta ascending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta

[Term]
id: UBERON:0009095
name: tip of renal papilla
synonym: "papillary tip" EXACT []
synonym: "papillary tips" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0001228 ! renal papilla

[Term]
id: UBERON:0009115
name: thoracic thymus
def: "A mature thymus that is entirely part of thoracic region." []
is_a: UBERON:0002370 ! thymus
is_a: UBERON:0005178 ! thoracic cavity element
intersection_of: UBERON:0002370 ! thymus
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0000915 ! thoracic segment of trunk

[Term]
id: UBERON:0009117
name: indifferent gonad
def: "A gonad prior to differentiating into a definitive testis or ovary." []
synonym: "gonad rudiment" RELATED []
is_a: UBERON:0000991 ! gonad
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0009196 ! indifferent external genitalia

[Term]
id: UBERON:0009122
name: adenohypophyseal placode
def: "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary" []
synonym: "pituitary placode" RELATED []
is_a: UBERON:0002546 ! cranial placode
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:0005497 ! non-neural ectoderm

[Term]
id: UBERON:0009128
name: lateral line placode
def: "An ectodermal placode that will develop into the components of the lateral line system" []
synonym: "lateral line placodes" RELATED []
is_a: UBERON:0003067 ! dorsolateral placode
is_a: UBERON:0006598 ! presumptive structure

[Term]
id: UBERON:0009141
name: craniocervical region vein
def: "A vein that is part of a craniocervical region." []
synonym: "craniocervical vein" EXACT []
synonym: "head and neck veins" EXACT []
synonym: "vein of head and neck" EXACT []
is_a: UBERON:0013140 ! systemic vein
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0004581 ! systemic venous system
relationship: part_of UBERON:0007811 ! craniocervical region

[Term]
id: UBERON:0009142
name: entire embryonic mesenchyme
def: "Sum total of mesenchyme in the embryo." []
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0009145
name: pharyngeal region of foregut
synonym: "pharyngeal region" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0001041 ! foregut
relationship: part_of UBERON:0001557 ! upper respiratory tract

[Term]
id: UBERON:0009196
name: indifferent external genitalia
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004176 ! external genitalia
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0009198
name: craniofacial suture
def: "Any suture between cranial and/or facial bones." []
synonym: "articulation of skull bones" RELATED []
synonym: "joint of the skull bones" EXACT []
relationship: part_of UBERON:0010323 ! cranial skeletal system

[Term]
id: UBERON:0009200
name: limb epidermis
def: "The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." []
is_a: UBERON:0001003 ! skin epidermis
is_a: UBERON:3000981 ! limb external integument structure
intersection_of: UBERON:0001003 ! skin epidermis
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0009201
name: nephric duct
def: "A nephric duct is a tube that drains a primitive kidney[GO]." []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0006553 ! renal duct
is_a: UBERON:0006555 ! excretory tube
union_of: UBERON:0003060 ! pronephric duct
union_of: UBERON:0003074 ! mesonephric duct
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0009202
name: vasa recta descending limb
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0004726 ! vasa recta

[Term]
id: UBERON:0009204
name: medial nasal process mesenchyme
def: "Mesenchyme that is part of a medial nasal prominence." []
is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004068 ! medial nasal prominence
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0004068 ! medial nasal prominence

[Term]
id: UBERON:0009210
name: pharyngeal membrane
def: "A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo." []
synonym: "branchial arch membrane" EXACT []
synonym: "branchial membrane" EXACT []
synonym: "pharyngeal membrane" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: has_part UBERON:0000924 ! ectoderm
relationship: has_part UBERON:0000925 ! endoderm
relationship: part_of UBERON:0002539 ! pharyngeal arch

[Term]
id: UBERON:0009213
name: pharyngeal membrane of 1st arch
def: "A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch." []
synonym: "1st branchial membrane" EXACT []
synonym: "1st pharyngeal membrane" EXACT []
synonym: "future tympanic membrane" EXACT []
synonym: "tympanic membrane primordium" EXACT []
is_a: UBERON:0009210 ! pharyngeal membrane
relationship: part_of UBERON:0004362 ! pharyngeal arch 1

[Term]
id: UBERON:0009292
name: embryonic nasal process
synonym: "nasal placode" RELATED []
is_a: UBERON:0012314 ! embryonic facial prominence

[Term]
id: UBERON:0009477
name: associated mesenchyme of otic placode
def: "Mesenchyme that is part of a otic placode." []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003069 ! otic placode
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0003069 ! otic placode

[Term]
id: UBERON:0009479
name: ectoderm of buccopharyngeal membrane
def: "An ectoderm that is part of a buccopharyngeal membrane." []
is_a: UBERON:0000924 ! ectoderm
intersection_of: UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0006211 ! buccopharyngeal membrane
relationship: part_of UBERON:0006211 ! buccopharyngeal membrane

[Term]
id: UBERON:0009480
name: endoderm of buccopharyngeal membrane
def: "An endoderm that is part of a buccopharyngeal membrane." []
is_a: UBERON:0000925 ! endoderm
intersection_of: UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0006211 ! buccopharyngeal membrane
relationship: part_of UBERON:0006211 ! buccopharyngeal membrane

[Term]
id: UBERON:0009482
name: associated mesenchyme of foregut-midgut junction
def: "Mesenchyme that is part of a foregut-midgut junction." []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0006235 ! foregut-midgut junction
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0009483
name: mesentery of foregut-midgut junction
def: "A mesentery that is part of a foregut-midgut junction." []
synonym: "foregut-midgut junction mesentery" EXACT []
is_a: UBERON:0002095 ! mesentery
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0006235 ! foregut-midgut junction
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0009494
name: pharyngeal arch mesenchymal region
def: "A portion of mesenchymal tissue associated with an individual pharyngeal arch." []
synonym: "branchial arch mesenchyme" EXACT []
synonym: "pharyngeal arch mesenchyme" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005253 ! head mesenchyme
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme

[Term]
id: UBERON:0009497
name: epithelium of foregut-midgut junction
def: "An epithelium that is part of a foregut-midgut junction." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0003929 ! digestive tract epithelium
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0006235 ! foregut-midgut junction
relationship: develops_from UBERON:0009550 ! endoderm of foregut-midgut junction
relationship: part_of UBERON:0003929 ! digestive tract epithelium
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0009500
name: associated mesenchyme of otocyst
def: "Mesenchyme that is part of a ear vesicle." []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003051 ! ear vesicle
relationship: develops_from UBERON:0009477 ! associated mesenchyme of otic placode
relationship: part_of UBERON:0003051 ! ear vesicle

[Term]
id: UBERON:0009501
name: mesenchyme of fronto-nasal process
def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head" []
synonym: "frontonasal mesenchyme" EXACT []
synonym: "naso-frontal mesenchyme" EXACT []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004066 ! frontonasal prominence
relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0004066 ! frontonasal prominence

[Term]
id: UBERON:0009503
name: mesenchyme of hindgut
def: "Mesenchyme that is part of a developing hindgut." []
synonym: "hindgut associated mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001046 ! hindgut
relationship: part_of UBERON:0001046 ! hindgut

[Term]
id: UBERON:0009505
name: mesenchyme of trachea
def: "Mesenchyme that is part of a developing trachea." []
synonym: "trachea associated mesenchyme" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0003126 ! trachea

[Term]
id: UBERON:0009506
name: mesenchyme of middle ear
def: "Mesenchyme that is part of a developing middle ear." []
synonym: "middle ear associated mesenchyme" EXACT []
synonym: "otic mesenchyme" BROAD []
is_a: UBERON:0005253 ! head mesenchyme
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001756 ! middle ear
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0009521
name: anal membrane endodermal component
def: "An endoderm that is part of a anal region." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0001353 ! anal region
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0009523
name: mesenchyme of handplate
def: "Mesenchyme that is part of a handplate." []
synonym: "hand plate mesenchyme" EXACT []
synonym: "handplate mesenchyme" EXACT []
is_a: UBERON:0010377 ! mesenchyme from somatopleure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0006875 ! handplate
relationship: develops_from UBERON:0003413 ! pectoral appendage bud mesenchyme
relationship: part_of UBERON:0006875 ! handplate

[Term]
id: UBERON:0009536
name: vascular element of left lung
def: "A vascular plexus that is part of a left lung." []
is_a: UBERON:0000102 ! lung vasculature
is_a: UBERON:0005629 ! vascular plexus
intersection_of: UBERON:0005629 ! vascular plexus
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0009537
name: vascular element of right lung
def: "A vascular plexus that is part of a right lung." []
is_a: UBERON:0000102 ! lung vasculature
is_a: UBERON:0005629 ! vascular plexus
intersection_of: UBERON:0005629 ! vascular plexus
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0009550
name: endoderm of foregut-midgut junction
def: "An endoderm that is part of a foregut-midgut junction." []
is_a: UBERON:0000925 ! endoderm
intersection_of: UBERON:0000925 ! endoderm
intersection_of: part_of UBERON:0006235 ! foregut-midgut junction
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0009566
name: intestinal submucosa
def: "A submucosa that is part of a intestine." []
synonym: "submucosa of intestine" EXACT []
is_a: UBERON:0018257 ! submucosa of digestive tract
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 ! wall of intestine

[Term]
id: UBERON:0009569
name: subdivision of trunk
synonym: "region of trunk" EXACT []
synonym: "trunk subdivision" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0009580
name: diencephalon mantle layer
synonym: "diencephalon lateral wall mantle layer" EXACT []
synonym: "mantle layer lateral wall diencephalon" EXACT []
is_a: UBERON:0004061 ! neural tube mantle layer
intersection_of: UBERON:0004061 ! neural tube mantle layer
intersection_of: part_of UBERON:0006222 ! future diencephalon
relationship: part_of UBERON:0006222 ! future diencephalon

[Term]
id: UBERON:0009581
name: midbrain mantle layer
synonym: "mantle layer lateral wall mesencephalon" RELATED []
synonym: "mantle layer lateral wall midbrain" EXACT []
synonym: "midbrain lateral wall mantle layer" EXACT []
is_a: UBERON:0004061 ! neural tube mantle layer
intersection_of: UBERON:0004061 ! neural tube mantle layer
intersection_of: part_of UBERON:0009616 ! presumptive midbrain
relationship: part_of UBERON:0009616 ! presumptive midbrain

[Term]
id: UBERON:0009584
name: 1st arch mandibular mesenchyme
def: "Mesenchyme that is part of a 1st arch mandibular component." []
synonym: "mandibular component mesenchyme" RELATED []
synonym: "mandibular mesenchyme" RELATED []
synonym: "mesenchymal region of mandibular component of first pharyngeal arch" EXACT []
synonym: "mesenchyme of mandibular component" EXACT []
is_a: UBERON:0010042 ! 1st arch mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0007237 ! 1st arch mandibular component
relationship: part_of UBERON:0007237 ! 1st arch mandibular component

[Term]
id: UBERON:0009602
name: left lung associated mesenchyme
def: "Mesenchyme that is part of a developing left lung." []
is_a: UBERON:0004883 ! lung mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002168 ! left lung
relationship: part_of UBERON:0002168 ! left lung

[Term]
id: UBERON:0009603
name: right lung associated mesenchyme
def: "Mesenchyme that is part of a developing right lung." []
is_a: UBERON:0004883 ! lung mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002167 ! right lung
relationship: part_of UBERON:0002167 ! right lung

[Term]
id: UBERON:0009610
name: forebrain neural plate
def: "A neural plate that develops_from a future forebrain." []
is_a: UBERON:0003075 ! neural plate
intersection_of: UBERON:0003075 ! neural plate
intersection_of: develops_from UBERON:0006240 ! future forebrain
relationship: develops_from UBERON:0006240 ! future forebrain
relationship: part_of UBERON:0003056 ! pre-chordal neural plate

[Term]
id: UBERON:0009611
name: midbrain neural plate
def: "A neural plate that develops_from a presumptive midbrain." []
is_a: UBERON:0003075 ! neural plate
intersection_of: UBERON:0003075 ! neural plate
intersection_of: develops_from UBERON:0009616 ! presumptive midbrain
relationship: develops_from UBERON:0009616 ! presumptive midbrain
relationship: part_of UBERON:0003056 ! pre-chordal neural plate

[Term]
id: UBERON:0009616
name: presumptive midbrain
def: "A presumptive structure that has the potential to develop into a midbrain." []
synonym: "early midbrain" RELATED []
synonym: "future midbrain" RELATED []
synonym: "mesencephalon" RELATED []
synonym: "presumptive mesencephalon" EXACT []
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0003080 ! anterior neural tube
relationship: develops_from UBERON:0010286 ! midbrain neural tube
relationship: part_of UBERON:0006238 ! future brain

[Term]
id: UBERON:0009617
name: head paraxial mesoderm
def: "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." []
synonym: "cephalic paraxial mesenchyme" EXACT []
synonym: "cephalic paraxial mesoderm" EXACT []
synonym: "cranial paraxial mesenchyme" EXACT []
synonym: "cranial paraxial mesoderm" EXACT []
synonym: "head paraxial mesenchyme" EXACT []
synonym: "somitomere" RELATED []
synonym: "somitomeric mesoderm" RELATED []
is_a: UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0003077 ! paraxial mesoderm
relationship: part_of UBERON:0005253 ! head mesenchyme

[Term]
id: UBERON:0009622
name: pronephric proximal straight tubule
def: "A proximal straight tubule that is part of a pronephros." []
synonym: "proximal straight tubules" RELATED []
is_a: UBERON:0001290 ! proximal straight tubule
is_a: UBERON:0005310 ! pronephric nephron tubule
intersection_of: UBERON:0001290 ! proximal straight tubule
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0002120 ! pronephros
relationship: part_of UBERON:0005309 ! pronephric nephron
relationship: part_of UBERON:0006173 ! pronephric proximal tubule

[Term]
id: UBERON:0009644
name: trachea non-cartilage connective tissue
is_a: UBERON:0003571 ! trachea connective tissue

[Term]
id: UBERON:0009647
name: tympanic membrane epithelium
def: "One of the two epithelia which make up the tympanic membrane (along with the fibrous layer)" []
synonym: "tympanic epithelium" EXACT []
synonym: "tympanic membrane epithelial layer" EXACT []
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0010071 ! layer of tympanic membrane
is_a: UBERON:0015813 ! middle ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002364 ! tympanic membrane
disjoint_from: UBERON:0010070 ! intermediate layer of tympanic membrane
relationship: part_of UBERON:0002364 ! tympanic membrane

[Term]
id: UBERON:0009648
name: eyelid subcutaneous connective tissue
def: "A eyelid connective tissue that is part of a hypodermis." []
synonym: "superficial fascia of eyelid" RELATED []
is_a: UBERON:0003581 ! eyelid connective tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003581 ! eyelid connective tissue
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0009651
name: nephron tubule basement membrane
def: "A basement membrane that is part of a nephron tubule." []
synonym: "kidney tubule basement membrane" EXACT []
synonym: "renal tubular basement membrane" EXACT []
synonym: "renal tubule basement membrane" EXACT []
is_a: UBERON:0005769 ! basement membrane of epithelium
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0004810 ! nephron tubule epithelium

[Term]
id: UBERON:0009652
name: bronchus basement membrane
def: "A basement membrane that is part of a bronchus." []
synonym: "bronchial basement membrane" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0015329 ! respiratory system basement membrane
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0009653
name: trachea basement membrane
def: "A basement membrane that is part of a trachea." []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015329 ! respiratory system basement membrane
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0009644 ! trachea non-cartilage connective tissue

[Term]
id: UBERON:0009661
name: midbrain nucleus
def: "Nucleus located in the midbrain." []
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain

[Term]
id: UBERON:0009662
name: hindbrain nucleus
def: "Nucleus located within the hindbrain." []
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0009663
name: telencephalic nucleus
def: "A nucleus of brain that is part of a telencephalon." []
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0009664
name: gut mesentery
synonym: "peritoneal cavity mesentary" RELATED []
synonym: "peritoneal mesentary" RELATED []
is_a: UBERON:0002095 ! mesentery

[Term]
id: UBERON:0009678
name: tooth row
def: "Anatomical cluster consisting of adjacent teeth constituting a row." []
synonym: "dental arcade" EXACT []
synonym: "row of teeth" EXACT []
synonym: "tooth rows" EXACT []
is_a: UBERON:0003672 ! dentition
is_a: UBERON:0034926 ! anatomical row

[Term]
id: UBERON:0009679
name: set of lower jaw teeth
def: "A tooth row that is part of a skeleton of lower jaw." []
synonym: "arcus dentalis inferior" EXACT []
synonym: "lower dental arcade" EXACT []
synonym: "lower jaw teeth" EXACT []
synonym: "mandibular dental arcade" RELATED []
synonym: "set of all lower teeth" EXACT []
is_a: UBERON:0009678 ! tooth row
intersection_of: UBERON:0009678 ! tooth row
intersection_of: part_of UBERON:0003278 ! skeleton of lower jaw
relationship: part_of UBERON:0003278 ! skeleton of lower jaw

[Term]
id: UBERON:0009697
name: epithelium of appendix
def: "A epithelium that is part of a vermiform appendix." []
synonym: "appendix epithelium" EXACT []
synonym: "epithelium of vermiform appendix" EXACT []
is_a: UBERON:0005636 ! caecum epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: develops_from UBERON:0005636 ! caecum epithelium
relationship: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0003929 ! digestive tract epithelium
relationship: part_of UBERON:0004989 ! mucosa of appendix

[Term]
id: UBERON:0009712
name: endocardium of right ventricle
def: "Any endocardium that is part of the right ventricle of the heart." []
synonym: "endocardial lining of right ventricle" RELATED []
synonym: "right ventricle endocardial tissue" RELATED []
synonym: "right ventricle endocardium" EXACT []
synonym: "right ventricular endocardium" EXACT []
is_a: UBERON:0001081 ! endocardium of ventricle
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001081 ! endocardium of ventricle
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: develops_from UBERON:0004706 ! bulbus cordis
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: UBERON:0009713
name: endocardium of left ventricle
def: "Any endocardium that is part of the left ventricle of the heart." []
synonym: "endocardial lining of left ventricle" RELATED []
synonym: "left ventricle endocardial tissue" RELATED []
synonym: "left ventricle endocardium" EXACT []
synonym: "left ventricular endocardium" EXACT []
is_a: UBERON:0001081 ! endocardium of ventricle
intersection_of: UBERON:0001081 ! endocardium of ventricle
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: UBERON:0009722
name: entire pharyngeal arch endoderm
synonym: "pharyngeal arch endoderm" RELATED []
is_a: UBERON:0003258 ! endoderm of foregut
is_a: UBERON:0004814 ! upper respiratory tract epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0003929 ! digestive tract epithelium
relationship: part_of UBERON:0008814 ! pharyngeal arch system

[Term]
id: UBERON:0009744
name: lymph node medullary sinus
def: "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels" []
synonym: "lymph node medullary sinusoid" RELATED []
synonym: "medullary sinus" BROAD []
is_a: UBERON:0004111 ! anatomical conduit
relationship: part_of UBERON:0002007 ! medulla of lymph node

[Term]
id: UBERON:0009745
name: lymph node medullary cord
def: "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" []
synonym: "medullary cord" BROAD []
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0002007 ! medulla of lymph node

[Term]
id: UBERON:0009749
name: limb mesenchyme
def: "The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells." []
synonym: "limb mesoderm" RELATED []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0009751
name: cardiac mesenchyme
def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" []
synonym: "heart mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0009752
name: pancreas mesenchyme
def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas" []
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0009753
name: adrenal gland cortex zone
synonym: "adrenal cortical region" EXACT []
synonym: "region of adrenal cortex" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: part_of UBERON:0001235 ! adrenal cortex

[Term]
id: UBERON:0009758
name: abdominal ganglion
def: "A ganglion that is part of a abdominal segment of trunk." []
is_a: UBERON:0005173 ! abdominal segment element
is_a: UBERON:0007134 ! trunk ganglion
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk

[Term]
id: UBERON:0009773
name: renal tubule
def: "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." []
synonym: "renal tubule (generic)" EXACT []
synonym: "tubule of excretory system" EXACT []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0006555 ! excretory tube
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0009778
name: pleural sac
def: "A serous sac that has the pleura and the pleural cavity as parts." []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005906 ! serous sac
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0005906 ! serous sac
intersection_of: has_part UBERON:0000977 ! pleura
intersection_of: has_part UBERON:0002402 ! pleural cavity
relationship: has_part UBERON:0000977 ! pleura
relationship: has_part UBERON:0002402 ! pleural cavity
relationship: part_of UBERON:0001558 ! lower respiratory tract

[Term]
id: UBERON:0009842
name: glandular acinus
def: "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." []
synonym: "acini" RELATED []
synonym: "acinus" BROAD []
is_a: UBERON:0034922 ! cell cluster
relationship: part_of UBERON:0002530 ! gland

[Term]
id: UBERON:0009843
name: prostate epithelial cord
def: "A solid cord of prostate epithelium." []
synonym: "cord of prostate epithelium" EXACT []
synonym: "epithelial cord of prostate" EXACT []
is_a: UBERON:0005154 ! epithelial cord

[Term]
id: UBERON:0009845
name: urogenital sinus mesenchyme
def: "Mesenchyme that surrounds primitive urogenital sinus." []
synonym: "UGM" EXACT []
is_a: UBERON:0003104 ! mesenchyme

[Term]
id: UBERON:0009846
name: embryonic cloacal epithelium
def: "An epithelium that is part of a embryonic cloaca." []
synonym: "cloacal epithelium" BROAD []
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0009521 ! anal membrane endodermal component
is_a: UBERON:0012481 ! cloacal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000163 ! embryonic cloaca
relationship: develops_from UBERON:0003353 ! epithelium of hindgut
relationship: part_of UBERON:0000163 ! embryonic cloaca
relationship: part_of UBERON:0003929 ! digestive tract epithelium

[Term]
id: UBERON:0009847
name: prostate field
def: "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." []
synonym: "prostate primordium" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0007688 ! anlage
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0004902 ! urogenital sinus epithelium

[Term]
id: UBERON:0009854
name: digestive tract diverticulum
def: "Branch or outpocketing of the digestive tract." []
synonym: "diverticulum of gut" RELATED []
synonym: "intestinal pouch" RELATED []
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0009856 ! sac
intersection_of: UBERON:0009856 ! sac
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0009856
name: sac
synonym: "diverticulum" RELATED []
synonym: "pouch" EXACT []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0009859
name: endosteum
def: "A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones" []
is_a: UBERON:0000158 ! membranous layer
relationship: part_of UBERON:0002495 ! long bone

[Term]
id: UBERON:0009870
name: zone of stomach
def: "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." []
synonym: "gastric zone" EXACT []
synonym: "region of stomach" EXACT []
synonym: "section of stomach" EXACT []
is_a: UBERON:0009034 ! stomach region
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0000945 ! stomach

[Term]
id: UBERON:0009871
name: nephrogenic zone
def: "outer portion of the renal cortex. Site of formation of medullary and cortical elements." []
synonym: "nephrogenic tissue" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0009881
name: anterior lateral plate mesoderm
synonym: "ALPM" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0009882
name: anal column
def: "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP]" []
synonym: "column of Morgagni" EXACT []
synonym: "columnae anales" RELATED []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0009883
name: medullary ray
def: "A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla." []
synonym: "Ferrein's pyramid" EXACT []
synonym: "kidney medullary ray" EXACT []
synonym: "renal medullary ray" EXACT []
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: UBERON:0009889
name: secondary heart field
def: "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." []
synonym: "anterior heart field" EXACT []
synonym: "anterior/second heart field" EXACT []
synonym: "second heart field" EXACT []
synonym: "SHF" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007688 ! anlage
relationship: part_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: UBERON:0009891
name: facial mesenchyme
def: "Mesenchyme that is part of a developing face." []
synonym: "face mesenchyme" EXACT []
synonym: "mesenchyme of face" EXACT []
is_a: UBERON:0005253 ! head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0009911
name: lobule
synonym: "lobulus" EXACT []
is_a: UBERON:0000063 ! organ subunit

[Term]
id: UBERON:0009912
name: anatomical lobe
def: "A portion of an organ, such as the liver, lung, breast, or brain." []
synonym: "lobus" EXACT []
is_a: UBERON:0000063 ! organ subunit

[Term]
id: UBERON:0009913
name: renal lobe
def: "The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]." []
synonym: "kidney lobe" EXACT []
synonym: "lobi renales" RELATED []
synonym: "lobi renalis" EXACT []
synonym: "lobus renalis" EXACT []
is_a: UBERON:0009912 ! anatomical lobe
intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0009914
name: renal lobule
def: "The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys" []
synonym: "cortical lobule" RELATED []
synonym: "cortical lobule of kidney" RELATED []
synonym: "kidney lobule" EXACT []
synonym: "lobuli corticales renis" RELATED []
synonym: "lobulus corticalis renalis" RELATED []
synonym: "lobulus renalis" EXACT []
synonym: "renal cortical lobule" RELATED []
synonym: "renculus" RELATED []
synonym: "reniculus" RELATED []
synonym: "renunculus" RELATED []
is_a: UBERON:0009911 ! lobule
intersection_of: UBERON:0009911 ! lobule
intersection_of: part_of UBERON:0002113 ! kidney
relationship: has_part UBERON:0001285 ! nephron
relationship: has_part UBERON:0009883 ! medullary ray
relationship: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0009913 ! renal lobe

[Term]
id: UBERON:0009916
name: wall of ureter
def: "An anatomical wall that is part of a ureter." []
synonym: "ureteral wall" EXACT []
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000056 ! ureter
relationship: has_part UBERON:0005742 ! adventitia
relationship: has_part UBERON:0006660 ! muscular coat
relationship: part_of UBERON:0000056 ! ureter

[Term]
id: UBERON:0009918
name: retrotrapezoid nucleus
def: "The loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain" []
is_a: UBERON:0007635 ! nucleus of medulla oblongata
relationship: part_of UBERON:0001896 ! medulla oblongata

[Term]
id: UBERON:0009919
name: ureter smooth muscle
def: "The smooth muscle tissue surrounding the epithelium of the ureter" []
synonym: "ureteral smooth muscle" EXACT []
synonym: "ureteral smooth muscle layer" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0006855 ! muscular coat of ureter

[Term]
id: UBERON:0009920
name: optic neural crest
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
is_a: UBERON:0007530 ! migrating mesenchyme population
relationship: part_of UBERON:0007213 ! mesenchyme derived from head neural crest

[Term]
id: UBERON:0009950
name: olfactory bulb plexiform layer
synonym: "plexiform layer" BROAD []
is_a: UBERON:0004001 ! olfactory bulb layer

[Term]
id: UBERON:0009954
name: vomeronasal system
def: "A vertebrate nasal chemosensory system that is responsible for detecting intraspecific pheromonal cues as well as environmental odorants" []
is_a: UBERON:0001032 ! sensory system
relationship: part_of UBERON:0005725 ! olfactory system

[Term]
id: UBERON:0009955
name: neurogenic placode
def: "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." []
synonym: "neurogenic placodes" EXACT []
synonym: "placodae neurogenicae" RELATED []
is_a: UBERON:0002546 ! cranial placode
disjoint_from: UBERON:0011814 ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:2007013 ! preplacodal ectoderm

[Term]
id: UBERON:0009966
name: internodal tract
def: "A conducting pathway in the conducting tissue of heart through which electrical activity spreads from the SA node to the AV node." []
synonym: "interatrial conduction tract" EXACT []
synonym: "internodal conduction tract" EXACT []
synonym: "internodal fasciculus" EXACT []
synonym: "internodal tract muscle tissue" EXACT []
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
is_a: UBERON:0010131 ! conducting tissue of heart
relationship: part_of UBERON:0002350 ! conducting system of heart

[Term]
id: UBERON:0009967
name: spleen venous sinus
synonym: "sinus lienalis" EXACT []
synonym: "sinus splenicus" EXACT []
synonym: "splenic sinus" EXACT []
synonym: "venous sinus of red pulp of spleen" EXACT []
is_a: UBERON:0003497 ! abdomen blood vessel
is_a: UBERON:0006615 ! venous sinus
relationship: part_of UBERON:0001250 ! red pulp of spleen

[Term]
id: UBERON:0009969
name: statoacoustic epithelium
synonym: "stato-acoustic epithelium" EXACT []
is_a: UBERON:0006934 ! sensory epithelium

[Term]
id: UBERON:0009970
name: epithelium of pancreatic duct
def: "An epithelium that is part of a pancreatic duct." []
synonym: "pancreatic duct epithelium" EXACT []
synonym: "pancreatic ductal epithelium" EXACT []
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0013697 ! exocrine pancreas epithelium
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0007329 ! pancreatic duct
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0007329 ! pancreatic duct

[Term]
id: UBERON:0009971
name: principal gastric gland
def: "one of the gastric glands that secretes the hydrochloric acid of the gastric juice[Stedman's]." []
synonym: "acid gland" EXACT []
synonym: "gastric follicle" RELATED []
synonym: "gastric gland" BROAD []
synonym: "glandula gastrica propria" EXACT []
synonym: "main gastric gland" EXACT []
synonym: "oxyntic gland" EXACT []
synonym: "principal gland of fundus of stomach" EXACT []
synonym: "Wassman gland" RELATED []
is_a: UBERON:0000325 ! gastric gland

[Term]
id: UBERON:0010000
name: multicellular anatomical structure
def: "An anatomical structure that has more than one cell as a part." []
synonym: "multicellular structure" EXACT []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0010001
name: cell cluster organ
def: "A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function." []
is_a: UBERON:0000062 ! organ
is_a: UBERON:0034922 ! cell cluster
disjoint_from: UBERON:0011216 ! organ system subdivision

[Term]
id: UBERON:0010009
name: aggregate regional part of brain
def: "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." []
synonym: "set of nuclei of neuraxis" RELATED []
is_a: UBERON:0034923 ! disconnected anatomical group
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0010011
name: collection of basal ganglia
def: "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." []
synonym: "basal ganglia" EXACT []
synonym: "basal ganglia set" EXACT []
synonym: "basal nuclei" RELATED []
synonym: "basal nuclei (basal ganglia)" EXACT []
synonym: "cerebral nuclei" RELATED []
synonym: "set of basal ganglia" EXACT []
synonym: "set of basal nuclei" RELATED []
synonym: "subcortical nuclei" RELATED []
is_a: UBERON:0010009 ! aggregate regional part of brain
relationship: part_of UBERON:0000454 ! cerebral subcortex

[Term]
id: UBERON:0010031
name: 6th arch mesenchyme
def: "Mesenchyme that is part of a pharyngeal arch 6." []
synonym: "6th branchial arch mesenchyme" RELATED []
synonym: "6th pharyngeal arch mesenchyme" EXACT []
synonym: "pharyngeal arch 6 mesenchyme" RELATED []
is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0003117 ! pharyngeal arch 6
relationship: part_of UBERON:0003117 ! pharyngeal arch 6

[Term]
id: UBERON:0010038
name: fundic gastric gland
def: "The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach. They are simple tubes, two or more of which open into a single duct." []
synonym: "fundal gland" EXACT []
synonym: "fundus gland" EXACT []
synonym: "gastric fundal gland" EXACT []
synonym: "gastric fundus gland" EXACT []
synonym: "gastric gland of fundus of stomach" EXACT []
synonym: "glandulae gastricae" RELATED []
is_a: UBERON:0000325 ! gastric gland
is_a: UBERON:0000414 ! mucous gland
intersection_of: UBERON:0000325 ! gastric gland
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach

[Term]
id: UBERON:0010039
name: food storage organ
def: "An organ of the digestive tract that is capable of retaining and storing food" []
is_a: UBERON:0013765 ! digestive system element
relationship: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0010042
name: 1st arch mesenchyme
def: "Mesenchyme that is part of a pharyngeal arch 1." []
synonym: "mesenchyme of 1st arch" EXACT []
is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0004362 ! pharyngeal arch 1

[Term]
id: UBERON:0010045
name: 1st arch maxillary mesenchyme
def: "Mesenchyme that is part of a 1st arch maxillary component." []
synonym: "maxillary component mesenchyme" RELATED []
synonym: "maxillary mesenchyme" RELATED []
synonym: "mesenchyme of maxillary component" EXACT []
is_a: UBERON:0010042 ! 1st arch mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0007238 ! 1st arch maxillary component
relationship: part_of UBERON:0007238 ! 1st arch maxillary component

[Term]
id: UBERON:0010046
name: entire pharyngeal arch associated mesenchyme
def: "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." []
synonym: "associated mesenchyme of pharyngeal region" EXACT []
synonym: "entire branchial arch associated mesenchyme" EXACT []
synonym: "pharyngeal arch associated mesenchyme" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007524 ! dense mesenchyme tissue
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0008814 ! pharyngeal arch system

[Term]
id: UBERON:0010047
name: oral gland
def: "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." []
synonym: "buccal gland" NARROW []
synonym: "gland of oral opening" RELATED []
synonym: "gland of oral region" RELATED []
synonym: "mouth gland" RELATED []
synonym: "oral cavity gland" RELATED []
synonym: "oral region gland" RELATED []
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0003408 ! gland of gut
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000165 ! mouth
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0010056
name: future tongue
def: "A compound organ that has the potential to develop into a tongue." []
is_a: UBERON:0003103 ! compound organ
is_a: UBERON:0005423 ! developing anatomical structure
is_a: UBERON:0013765 ! digestive system element
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0010059
name: hypoglossal cord
is_a: UBERON:0002036 ! striated muscle tissue
relationship: part_of UBERON:0010056 ! future tongue

[Term]
id: UBERON:0010063
name: tympanic cavity epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0007499 ! epithelial sac
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015813 ! middle ear epithelium
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0010064
name: open anatomical space
def: "An anatomical space with at least one opening to another space or the exterior." []
is_a: UBERON:0000464 ! anatomical space

[Term]
id: UBERON:0010069
name: outer epithelial layer of tympanic membrane
def: "A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane" []
synonym: "cuticular layer of tympanic membrane" EXACT []
synonym: "cuticular stratum of tympanic membrane" EXACT []
synonym: "outer cuticular layer of tympanic membrane" EXACT []
synonym: "outer layer of tympanic membrane" EXACT []
synonym: "tympanic membrane external acoustic meatus epithelial component" EXACT []
is_a: UBERON:0009647 ! tympanic membrane epithelium
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0015814 ! outer ear epithelium
intersection_of: UBERON:0009647 ! tympanic membrane epithelium
intersection_of: part_of UBERON:0001352 ! external acoustic meatus
relationship: part_of UBERON:0001352 ! external acoustic meatus

[Term]
id: UBERON:0010070
name: intermediate layer of tympanic membrane
def: "The intermediate fibrous layer of the tympanic membrane." []
synonym: "connective tissue layer of tympanic membrane" EXACT []
synonym: "fibrous layer of tympanic membrane" EXACT []
synonym: "fibrous stratum of tympanic membrane" EXACT []
synonym: "intermediate fibrous layer of tympanic membrane" EXACT []
synonym: "tympanic endothelium" EXACT []
is_a: UBERON:0010071 ! layer of tympanic membrane

[Term]
id: UBERON:0010071
name: layer of tympanic membrane
synonym: "tympanic membrane layer" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0002364 ! tympanic membrane

[Term]
id: UBERON:0010074
name: chromaffin system
def: "Organ system subdivision that consists primarily of chromaffin cells and their supporting structures." []
synonym: "argentaffin system" RELATED []
synonym: "chromaffin tissue" RELATED []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011216 ! organ system subdivision
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0010077
name: cuboidal epithelium
def: "An epithelium consisting of cuboidal epithelial cells." []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0010092
name: future metencephalon
def: "A developing anatomical structure that has the potential to develop into a metencephalon." []
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0010129
name: femur cartilage element
def: "A femur endochondral element that is composed primarily of a cartilage tissue." []
synonym: "femoral cartilage condensation" EXACT []
is_a: UBERON:0005254 ! upper leg mesenchyme
is_a: UBERON:0005863 ! cartilaginous condensation
is_a: UBERON:0010881 ! limb cartilage element
is_a: UBERON:0010885 ! hindlimb cartilage element
is_a: UBERON:0015052 ! femur endochondral element
relationship: develops_from UBERON:0006234 ! femur pre-cartilage condensation
relationship: part_of UBERON:0005254 ! upper leg mesenchyme

[Term]
id: UBERON:0010130
name: autopod plate
def: "The distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. manus, pes, paw)" []
synonym: "limb plate" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0004347 ! limb bud

[Term]
id: UBERON:0010131
name: conducting tissue of heart
def: "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." []
synonym: "specialized conducting tissue of heart" EXACT []
synonym: "specialized muscle tissue of heart" EXACT []
is_a: UBERON:0001133 ! cardiac muscle tissue

[Term]
id: UBERON:0010133
name: neuroendocrine gland
def: "any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli" []
is_a: UBERON:0002368 ! endocrine gland
intersection_of: UBERON:0002368 ! endocrine gland
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0010134
name: secretory circumventricular organ
def: "A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid." []
is_a: UBERON:0005408 ! circumventricular organ
is_a: UBERON:0010133 ! neuroendocrine gland
intersection_of: UBERON:0005408 ! circumventricular organ
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0000949 ! endocrine system

[Term]
id: UBERON:0010135
name: sensory circumventricular organ
def: "A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid." []
synonym: "humerosensory circumventricular organ" RELATED []
synonym: "humerosensory system" RELATED []
synonym: "humerosensory system organ" RELATED []
synonym: "sensitive circumventricular organs" RELATED []
synonym: "sensitive organs" RELATED []
synonym: "sensory circumventricular organs" RELATED []
synonym: "sensory CVOs" RELATED []
is_a: UBERON:0005408 ! circumventricular organ
intersection_of: UBERON:0005408 ! circumventricular organ
intersection_of: part_of UBERON:0001032 ! sensory system
relationship: part_of UBERON:0001032 ! sensory system

[Term]
id: UBERON:0010141
name: primitive sex cord of indifferent gonad
def: "A sex cord that is part of a indifferent gonad." []
synonym: "indifferent sex cord" EXACT []
synonym: "primitive sex cords" EXACT []
is_a: UBERON:0004909 ! epithelium of gonad
is_a: UBERON:0005295 ! sex cord
intersection_of: UBERON:0005295 ! sex cord
intersection_of: part_of UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0005891 ! coelomic epithelium
relationship: part_of UBERON:0009117 ! indifferent gonad

[Term]
id: UBERON:0010147
name: male accessory sex gland
def: "Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male." []
synonym: "male accessory gland" RELATED []
is_a: UBERON:0005399 ! male reproductive gland
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0010171
name: strand of hair of face
def: "A strand of hair that is part of a face." []
synonym: "face hair" EXACT []
synonym: "face hair strand" EXACT []
synonym: "facial hair" RELATED []
synonym: "hair of face" EXACT []
is_a: UBERON:0016446 ! hair of head
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0010186
name: male urethral gland
def: "any of the numerous small mucous-secreting glands located in the wall of the penile urethra" []
synonym: "gland of Littre" EXACT []
synonym: "gland of male urethra" EXACT []
synonym: "glandulae urethrales urethrae masculinae" RELATED []
synonym: "Littre's gland" EXACT []
synonym: "male urethra gland" EXACT []
synonym: "urethral gland (male)" EXACT []
is_a: UBERON:0001338 ! urethral gland
intersection_of: UBERON:0001338 ! urethral gland
intersection_of: part_of UBERON:0001333 ! male urethra
relationship: part_of UBERON:0001333 ! male urethra

[Term]
id: UBERON:0010187
name: female urethral gland
def: "An urethral gland that is part of a female urethra." []
synonym: "female urethra gland" EXACT []
synonym: "gland of female urethra" EXACT []
synonym: "urethral gland (female)" EXACT []
is_a: UBERON:0001338 ! urethral gland
intersection_of: UBERON:0001338 ! urethral gland
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: part_of UBERON:0001334 ! female urethra

[Term]
id: UBERON:0010188
name: protuberance
def: "A roughly circular bulge in a surface." []
is_a: UBERON:0003102 ! surface structure

[Term]
id: UBERON:0010190
name: pair of dorsal aortae
def: "the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" []
synonym: "paired dorsal aortae" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
relationship: has_part UBERON:0005805 ! dorsal aorta
relationship: part_of UBERON:0010191 ! aortic system

[Term]
id: UBERON:0010191
name: aortic system
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0004571 ! systemic arterial system

[Term]
id: UBERON:0010202
name: lateral line
def: "The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." []
synonym: "lateral lines" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0009128 ! lateral line placode
relationship: part_of UBERON:0002540 ! lateral line system

[Term]
id: UBERON:0010225
name: thalamic complex
def: "A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]." []
is_a: UBERON:0007245 ! nuclear complex of neuraxis
is_a: UBERON:0019269 ! gray matter of diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0010230
name: eyeball of camera-type eye
def: "The core globe-shaped component of the camera-type eye." []
synonym: "bulbus oculi" EXACT []
synonym: "eye" RELATED []
synonym: "eye globe" EXACT []
synonym: "eyeball" EXACT []
synonym: "globe" RELATED []
is_a: UBERON:0000020 ! sense organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0010233
name: stroma of thyroid gland
def: "The connective tissue that supports the lobules and follicles of the thyroid gland." []
synonym: "thyroid gland stroma" EXACT []
synonym: "thyroid stroma" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0010243
name: merocrine gland
def: "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." []
is_a: UBERON:0002365 ! exocrine gland

[Term]
id: UBERON:0010252
name: 1st arch mandibular mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." []
is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme
is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0009584 ! 1st arch mandibular mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0007098 ! mandibular neural crest
relationship: part_of UBERON:0009584 ! 1st arch mandibular mesenchyme
relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest

[Term]
id: UBERON:0010253
name: 1st arch maxillary mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." []
is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme
is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme
relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest

[Term]
id: UBERON:0010254
name: 2nd arch mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme." []
synonym: "branchial arch 2 mesenchyme from neural crest" RELATED []
synonym: "neural crest derived arch 2 mesenchyme" EXACT []
synonym: "pharyngeal arch 2 mesenchyme from neural crest" EXACT []
is_a: UBERON:0005689 ! 2nd arch mesenchyme
is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest
is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0005689 ! 2nd arch mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0007099 ! hyoid neural crest
relationship: part_of UBERON:0005689 ! 2nd arch mesenchyme
relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest

[Term]
id: UBERON:0010257
name: 6th arch mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." []
synonym: "branchial arch 6 mesenchyme from neural crest" RELATED []
synonym: "neural crest derived arch 6 mesenchyme" EXACT []
synonym: "pharyngeal arch 6 mesenchyme from neural crest" EXACT []
is_a: UBERON:0010031 ! 6th arch mesenchyme
is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest
is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0010031 ! 6th arch mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0003852 ! rhombencephalon neural crest
relationship: part_of UBERON:0010031 ! 6th arch mesenchyme
relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest

[Term]
id: UBERON:0010258
name: mesenchyme from rhombencephalic neural crest
def: "Mesenchyme that develops_from a rhombencephalon neural crest." []
is_a: UBERON:0007213 ! mesenchyme derived from head neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0003852 ! rhombencephalon neural crest
relationship: develops_from UBERON:0003852 ! rhombencephalon neural crest
relationship: part_of UBERON:0007213 ! mesenchyme derived from head neural crest

[Term]
id: UBERON:0010259
name: 1st arch mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." []
synonym: "branchial arch 1 mesenchyme from neural crest" RELATED []
synonym: "mesenchyme derived from neural crest of mesenchyme of 1st arch" EXACT []
synonym: "neural crest derived arch 1 mesenchyme" EXACT []
synonym: "pharyngeal arch 1 mesenchyme from neural crest" EXACT []
is_a: UBERON:0010042 ! 1st arch mesenchyme
is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest
is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0010042 ! 1st arch mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0003852 ! rhombencephalon neural crest
relationship: part_of UBERON:0010042 ! 1st arch mesenchyme

[Term]
id: UBERON:0010260
name: umbilical blood vessel
def: "One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta." []
synonym: "allantoic vessel" EXACT []
synonym: "umbilical cord blood vessel" EXACT []
synonym: "umbilical cord blood vessels" RELATED []
synonym: "umbilical vasculature" RELATED []
synonym: "umbilical vessel" EXACT []
is_a: UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0010276
name: space in vertebral column
def: "Any anatomical space that is part of a vertebral column." []
synonym: "vertebral column opening" EXACT []
synonym: "vertebral conduit" EXACT []
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: part_of UBERON:0001130 ! vertebral column
relationship: part_of UBERON:0001130 ! vertebral column

[Term]
id: UBERON:0010285
name: midbrain basal plate
def: "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." []
synonym: "basal plate midbrain" EXACT []
synonym: "basal plate midbrain region" EXACT []
is_a: UBERON:0002020 ! gray matter
relationship: part_of UBERON:0009581 ! midbrain mantle layer
relationship: part_of UBERON:0010286 ! midbrain neural tube

[Term]
id: UBERON:0010286
name: midbrain neural tube
def: "Portion of neural tube that gives rise to the midbrain." []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0003080 ! anterior neural tube

[Term]
id: UBERON:0010291
name: layer of sclera
def: "." []
is_a: UBERON:0004923 ! organ component layer
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: UBERON:0010294
name: scleral endothelium
def: "An endothelium that is part of a sclera." []
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0010291 ! layer of sclera
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001773 ! sclera
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: UBERON:0010295
name: substantia propria of sclera
def: "A stroma that is part of a sclera." []
synonym: "scleral stroma" EXACT []
synonym: "stroma of sclera" EXACT []
synonym: "subsantia propria" BROAD []
synonym: "subsantia propria sclerae" EXACT []
synonym: "substantia propria sclerae" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0010291 ! layer of sclera
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001773 ! sclera
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: UBERON:0010302
name: amnioserosa
def: "A single extraembryonic epithelium, which closes the germband dorsally." []
synonym: "amnion-serosa" RELATED []
is_a: UBERON:0010303 ! extraembryonic epithelium

[Term]
id: UBERON:0010303
name: extraembryonic epithelium
def: "An epithelium that is part of a extraembryonic structure." []
synonym: "extra-embryonic epithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0005292 ! extraembryonic tissue
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0000478 ! extraembryonic structure

[Term]
id: UBERON:0010304
name: non-keratinized stratified squamous epithelium
def: "Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus." []
synonym: "epithelium stratificatum squamosum noncornificatum" EXACT []
synonym: "nonkeratinizing stratified squamous epithelium" EXACT []
synonym: "stratified squamous non-keratinized epithelium" EXACT []
synonym: "stratified squamous nonkeratinizing epithelium" EXACT []
is_a: UBERON:0006915 ! stratified squamous epithelium

[Term]
id: UBERON:0010305
name: region of conjunctiva
def: "One of the three major regions of the conjunctiva." []
synonym: "conjunctiva subdivision" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000064 ! organ part
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva

[Term]
id: UBERON:0010312
name: immature eye
def: "Developing anatomical structure that develops into the eyeball and associated structures." []
synonym: "future eye" EXACT []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003071 ! eye primordium

[Term]
id: UBERON:0010313
name: neural crest-derived structure
def: "An anatomical structure that develops from the neural crest." []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0002342 ! neural crest

[Term]
id: UBERON:0010314
name: structure with developmental contribution from neural crest
def: "An anatomical structure that has some part that develops from the neural crest." []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0010316
name: germ layer / neural crest
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0002532 ! epiblast (generic)

[Term]
id: UBERON:0010321
name: skeletal element of eye region
def: "A skeletal element that is part of a orbital region." []
synonym: "eye skeleton" RELATED []
synonym: "ocular skeleton" RELATED []
synonym: "skeletal element of orbital region" RELATED []
is_a: UBERON:0004765 ! skeletal element
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0004765 ! skeletal element
intersection_of: part_of UBERON:0004088 ! orbital region
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0004088 ! orbital region
relationship: part_of UBERON:0011156 ! facial skeleton

[Term]
id: UBERON:0010323
name: cranial skeletal system
def: "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." []
synonym: "cranial skeleton" NARROW []
synonym: "cranium" RELATED []
synonym: "osteocranium" NARROW []
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: part_of UBERON:0011137 ! axial skeletal system

[Term]
id: UBERON:0010328
name: limb bud mesenchyme
def: "Mesenchyme that is part of a limb bud." []
is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004347 ! limb bud
relationship: part_of UBERON:0004347 ! limb bud

[Term]
id: UBERON:0010329
name: paired limb/fin bud mesenchyme
def: "Mesenchyme that is part of a limb/fin bud." []
is_a: UBERON:0010377 ! mesenchyme from somatopleure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0004357 ! paired limb/fin bud
relationship: develops_from UBERON:0010377 ! mesenchyme from somatopleure
relationship: part_of UBERON:0004357 ! paired limb/fin bud

[Term]
id: UBERON:0010330
name: eyelid mesenchyme
def: "Mesenchyme that is part of a developing eyelid." []
is_a: UBERON:0003314 ! eye mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0010332
name: epithelium of handplate
def: "An epithelium that is part of a handplate." []
synonym: "handplate epithelium" EXACT []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0006875 ! handplate
relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm
relationship: part_of UBERON:0006875 ! handplate

[Term]
id: UBERON:0010333
name: extraembryonic membrane mesenchyme
def: "Mesenchyme that is part of a extraembryonic membrane." []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005292 ! extraembryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm
relationship: part_of UBERON:0005631 ! extraembryonic membrane

[Term]
id: UBERON:0010336
name: mandibular process mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." []
is_a: UBERON:0006905 ! mandibular process mesenchyme
is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0006905 ! mandibular process mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0010252 ! 1st arch mandibular mesenchyme from neural crest
relationship: part_of UBERON:0006905 ! mandibular process mesenchyme

[Term]
id: UBERON:0010337
name: mandibular process mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0006904 ! head mesenchyme from mesoderm
is_a: UBERON:0006905 ! mandibular process mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0006905 ! mandibular process mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: develops_from UBERON:0010339 ! 1st arch mandibular mesenchyme from head mesenchyme
relationship: part_of UBERON:0006905 ! mandibular process mesenchyme

[Term]
id: UBERON:0010338
name: 1st arch maxillary mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." []
is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme
is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme

[Term]
id: UBERON:0010339
name: 1st arch mandibular mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." []
is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme
is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0009584 ! 1st arch mandibular mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0009584 ! 1st arch mandibular mesenchyme

[Term]
id: UBERON:0010341
name: 1st arch mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." []
synonym: "mesenchyme derived from head mesoderm of mesenchyme of 1st arch" EXACT []
is_a: UBERON:0006904 ! head mesenchyme from mesoderm
is_a: UBERON:0010042 ! 1st arch mesenchyme
is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0010042 ! 1st arch mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0010042 ! 1st arch mesenchyme

[Term]
id: UBERON:0010343
name: 2nd arch mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme." []
synonym: "branchial arch 2 mesenchyme from head mesenchyme" RELATED []
synonym: "head mesenchyme derived arch 2 mesenchyme" EXACT []
synonym: "mesenchyme derived from head mesoderm of mesenchyme of 2nd arch" EXACT []
synonym: "pharyngeal arch 2 mesenchyme from head mesenchyme" EXACT []
is_a: UBERON:0005689 ! 2nd arch mesenchyme
is_a: UBERON:0006904 ! head mesenchyme from mesoderm
is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0005689 ! 2nd arch mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0005689 ! 2nd arch mesenchyme

[Term]
id: UBERON:0010347
name: 6th arch mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." []
synonym: "branchial arch 6 mesenchyme from head mesenchyme" RELATED []
synonym: "head mesenchyme derived arch 6 mesenchyme" EXACT []
synonym: "pharyngeal arch 6 mesenchyme from head mesenchyme" EXACT []
is_a: UBERON:0006904 ! head mesenchyme from mesoderm
is_a: UBERON:0010031 ! 6th arch mesenchyme
is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0010031 ! 6th arch mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0010031 ! 6th arch mesenchyme

[Term]
id: UBERON:0010359
name: pharyngeal arch mesenchyme from neural crest
def: "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." []
synonym: "arch mesenchyme from neural crest" EXACT []
synonym: "branchial arch mesenchyme from neural crest" EXACT []
synonym: "neural crest derived arch mesenchyme" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0014387 ! mesenchyme derived from neural crest
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
intersection_of: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme

[Term]
id: UBERON:0010360
name: pharyngeal arch mesenchyme from head mesenchyme
def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." []
synonym: "arch mesenchyme from head mesenchyme" EXACT []
synonym: "branchial arch mesenchyme from head mesenchyme" EXACT []
synonym: "head mesenchyme derived arch mesenchyme" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
intersection_of: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme
relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm
relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme

[Term]
id: UBERON:0010363
name: endochondral element
def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." []
synonym: "endochondral replacement element" EXACT []
is_a: UBERON:0004765 ! skeletal element

[Term]
id: UBERON:0010364
name: dermal skeleton
def: "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." []
synonym: "dermal skeletal system" RELATED []
synonym: "dermoskeleton" RELATED []
synonym: "desmoskeleton" RELATED []
synonym: "exoskeleton" BROAD []
is_a: UBERON:0010912 ! subdivision of skeleton

[Term]
id: UBERON:0010365
name: odontoid tissue
def: "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." []
synonym: "dental tissue" RELATED []
synonym: "odontogenic tissue" EXACT []
synonym: "portion of substance of tooth" NARROW []
synonym: "substance of tooth" NARROW []
synonym: "tooth hard tissue" RELATED []
synonym: "tooth substance" NARROW []
synonym: "tooth tissue" RELATED []
is_a: UBERON:0004755 ! skeletal tissue
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0004755 ! skeletal tissue
intersection_of: develops_from UBERON:0001763 ! odontogenic papilla
intersection_of: part_of UBERON:0010364 ! dermal skeleton
relationship: develops_from UBERON:0001763 ! odontogenic papilla
relationship: part_of UBERON:0010364 ! dermal skeleton

[Term]
id: UBERON:0010366
name: conjunctival vasculature
def: "A vasculature that is part of a conjunctiva." []
synonym: "conjunctival veins" EXACT []
synonym: "conjunctival veins set" EXACT []
synonym: "set of conjunctival veins" EXACT []
synonym: "venae conjunctivales" EXACT []
is_a: UBERON:0002203 ! vasculature of eye
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva

[Term]
id: UBERON:0010367
name: conjunctival vein
def: "A vein that is part of a conjunctiva." []
synonym: "conjunctival blood vessel" BROAD []
is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0009141 ! craniocervical region vein
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0010366 ! conjunctival vasculature

[Term]
id: UBERON:0010368
name: pulmonary lobule
def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." []
synonym: "lobulus pulmonis" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0009911 ! lobule
intersection_of: UBERON:0009911 ! lobule
intersection_of: part_of UBERON:0002048 ! lung
relationship: has_part UBERON:0002187 ! terminal bronchiole
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0010371
name: ecto-epithelium
def: "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." []
synonym: "ectoderm-derived epithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000483 ! epithelium
intersection_of: develops_from UBERON:0000924 ! ectoderm
relationship: develops_from UBERON:0000924 ! ectoderm

[Term]
id: UBERON:0010375
name: pancreas dorsal primordium
synonym: "dorsal pancreas" RELATED []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0003921 ! pancreas primordium

[Term]
id: UBERON:0010376
name: pancreas ventral primordium
synonym: "ventral pancreas" RELATED []
is_a: UBERON:0001048 ! primordium
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0003921 ! pancreas primordium

[Term]
id: UBERON:0010377
name: mesenchyme from somatopleure
def: "Mesenchyme that develops_from a somatopleure." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007524 ! dense mesenchyme tissue
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0004874 ! somatopleure
intersection_of: part_of UBERON:0000922 ! embryo
relationship: develops_from UBERON:0004874 ! somatopleure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme

[Term]
id: UBERON:0010380
name: enteric nerve
def: "the neurons that innervate the esophagus, stomach, small and large bowel" []
is_a: UBERON:0034728 ! autonomic nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002005 ! enteric nervous system
relationship: part_of UBERON:0002005 ! enteric nervous system

[Term]
id: UBERON:0010386
name: Peyer's patch follicle
def: "A lymphoid follicle that is part of a Peyer's patch." []
synonym: "peyer's patch follicle" EXACT []
is_a: UBERON:0000444 ! lymphoid follicle
intersection_of: UBERON:0000444 ! lymphoid follicle
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: part_of UBERON:0001211 ! Peyer's patch

[Term]
id: UBERON:0010395
name: lymph node primary follicle
def: "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." []
synonym: "primary follicle of lymph node" EXACT []
is_a: UBERON:0010422 ! primary nodular lymphoid tissue
is_a: UBERON:0010748 ! lymph node follicle
intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: UBERON:0010409
name: ocular surface region
def: "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." []
synonym: "eye surface" EXACT []
synonym: "eye surface region" EXACT []
synonym: "ocular surface" EXACT []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0010418
name: urethral opening
def: "An orifice that is part of a lower urinary tract." []
synonym: "urethral orifice" EXACT []
is_a: UBERON:0000161 ! orifice
intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0001556 ! lower urinary tract
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: UBERON:0010422
name: primary nodular lymphoid tissue
def: "A lymphoid follicle containing naive B cells" []
synonym: "primary follicle" RELATED []
synonym: "primary lymphoid follicle" EXACT []
synonym: "primary lymphoid nodule" EXACT []
is_a: UBERON:0000444 ! lymphoid follicle

[Term]
id: UBERON:0010423
name: primary lymphoid nodule of tonsil
def: "A primary nodular lymphoid tissue that is part of a tonsil." []
synonym: "lymphoid nodule of tonsil" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010422 ! primary nodular lymphoid tissue
intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: UBERON:0010427
name: ciliary processes
def: "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." []
synonym: "ciliary process" RELATED []
synonym: "ciliary processes" EXACT []
synonym: "ciliary processes set" EXACT []
synonym: "processus ciliares" EXACT []
synonym: "processus ciliares" RELATED []
synonym: "set of ciliary processes" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0001775 ! ciliary body

[Term]
id: UBERON:0010498
name: pseudostratified columnar epithelium
def: "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." []
is_a: UBERON:0000485 ! simple columnar epithelium

[Term]
id: UBERON:0010499
name: pseudostratified ciliated columnar epithelium
def: "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." []
synonym: "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" EXACT []
is_a: UBERON:0007592 ! ciliated columnar epithelium
is_a: UBERON:0010498 ! pseudostratified columnar epithelium

[Term]
id: UBERON:0010521
name: electroreceptor organ
def: "An organ that is capable of detecting electrical stimulus" []
synonym: "electric sense organ" EXACT []
synonym: "electroreception organ" EXACT []
is_a: UBERON:0000020 ! sense organ

[Term]
id: UBERON:0010523
name: microcirculatory vessel
def: "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." []
synonym: "microcirculatory vessels" RELATED []
is_a: UBERON:0000055 ! vessel
relationship: part_of UBERON:0002049 ! vasculature

[Term]
id: UBERON:0010527
name: cavity of bone organ
def: "An organ cavity that surrounded_by a bone." []
synonym: "bone organ cavity" EXACT []
is_a: UBERON:0002558 ! organ cavity
intersection_of: UBERON:0002558 ! organ cavity
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0010528
name: pneumatic cavity of bone
synonym: "air space of bone" EXACT []
is_a: UBERON:0010527 ! cavity of bone organ
relationship: part_of UBERON:0008193 ! pneumatized bone

[Term]
id: UBERON:0010531
name: metanephros induced blastemal cells
def: "." []
synonym: "cap mesenchyme of metanephros of urinary system" RELATED []
synonym: "induced blastemal cells" EXACT []
synonym: "nephrogenic interstitium" RELATED []
synonym: "nephrogenic interstitium of nephrogenic zone" EXACT []
synonym: "peripheral blastema" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0009871 ! nephrogenic zone

[Term]
id: UBERON:0010532
name: primitive nephron
def: "An epithelial tube that is fated to become a nephron." []
synonym: "developing nephron" BROAD []
synonym: "future nephron" EXACT []
synonym: "presumptive nephron" EXACT []
synonym: "primitive nephron" BROAD []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0006555 ! excretory tube
relationship: develops_from UBERON:0004209 ! renal vesicle
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0010533
name: metanephros cortex
def: "The metanephric cortex is the outer region of the metanephros[GO]." []
is_a: UBERON:0001225 ! cortex of kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001225 ! cortex of kidney
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme
relationship: part_of UBERON:0000081 ! metanephros

[Term]
id: UBERON:0010534
name: primitive mesonephric nephron
def: "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." []
synonym: "developing mesonephric nephron" EXACT []
synonym: "primitive mesonephric nephron" EXACT []
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0010532 ! primitive nephron
intersection_of: UBERON:0010532 ! primitive nephron
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0010535
name: primitive metanephric nephron
def: "A primitive nephron that is part of a metanephros." []
synonym: "developing metanephric nephron" EXACT []
synonym: "primitive metanephric nephron" EXACT []
synonym: "primitive nephron" BROAD []
is_a: UBERON:0005106 ! metanephric tubule
is_a: UBERON:0010532 ! primitive nephron
intersection_of: UBERON:0010532 ! primitive nephron
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0000081 ! metanephros
relationship: part_of UBERON:0005113 ! metanephric cortex mesenchyme

[Term]
id: UBERON:0010536
name: nephron progenitor
is_a: UBERON:0000479 ! tissue
relationship: part_of UBERON:0003918 ! kidney mesenchyme

[Term]
id: UBERON:0010537
name: mesonephric nephron progenitor
def: "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010536 ! nephron progenitor
intersection_of: UBERON:0010536 ! nephron progenitor
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000080 ! mesonephros

[Term]
id: UBERON:0010538
name: paired limb/fin segment
def: "An appendage segment that is part of a limb/fin." []
synonym: "limb/fin segment" EXACT []
is_a: UBERON:0010758 ! subdivision of organism along appendicular axis
intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis
intersection_of: part_of UBERON:0004708 ! paired limb/fin
disjoint_from: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0004708 ! paired limb/fin

[Term]
id: UBERON:0010543
name: acropodial skeleton
def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]." []
synonym: "acropodial skeleton" EXACT []
synonym: "acropodium" RELATED []
synonym: "acropodium skeleton" EXACT []
synonym: "digital skeleton" RELATED []
synonym: "digits skeleton" RELATED []
synonym: "phalangeal skeleton" RELATED []
synonym: "set of phalanges" EXACT []
synonym: "skeletal parts of acropodial region" EXACT []
synonym: "skeletal parts of acropodium" RELATED []
synonym: "skeleton of digits" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010712 ! limb skeleton subdivision
relationship: has_part UBERON:0015023 ! phalanx endochondral element
relationship: part_of UBERON:0012150 ! skeleton of digitopodium
relationship: part_of UBERON:0012354 ! acropodium region

[Term]
id: UBERON:0010585
name: pedal digit phalanx pre-cartilage condensation
def: "A pre-cartilage condensation that is part of a pedal digit mesenchyme." []
synonym: "foot digit phalanx pre-cartilage condensation" NARROW []
synonym: "foot phalanx pre-cartilage condensation" EXACT []
synonym: "hind limb digit phalanx pre-cartilage condensation" EXACT []
synonym: "hindlimb phalanx pre-cartilage condensation" EXACT []
synonym: "pes phalanx pre-cartilage condensation" EXACT []
is_a: UBERON:0010700 ! phalanx pre-cartilage condensation
is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation
is_a: UBERON:0015030 ! pedal digit phalanx endochondral element

[Term]
id: UBERON:0010586
name: manual digit phalanx pre-cartilage condensation
def: "A pre-cartilage condensation that is part of a manual digit mesenchyme." []
synonym: "fore limb digit phalanx pre-cartilage condensation" EXACT []
synonym: "forelimb phalanx pre-cartilage condensation" EXACT []
synonym: "hand digit phalanx pre-cartilage condensation" NARROW []
synonym: "hand phalanx pre-cartilage condensation" EXACT []
synonym: "manus phalanx pre-cartilage condensation" EXACT []
is_a: UBERON:0010700 ! phalanx pre-cartilage condensation
is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation
is_a: UBERON:0015024 ! manual digit phalanx endochondral element

[Term]
id: UBERON:0010685
name: pedal digit phalanx cartilage element
def: "A cartilage element that is part of a pedal digit mesenchyme." []
synonym: "foot digit phalanx cartilage element" NARROW []
synonym: "hind limb digit phalanx cartilage condensation" EXACT []
is_a: UBERON:0010701 ! phalanx cartilage element
is_a: UBERON:0015030 ! pedal digit phalanx endochondral element
is_a: UBERON:0035129 ! pes cartilage element
relationship: develops_from UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation

[Term]
id: UBERON:0010686
name: manual digit phalanx cartilage element
def: "A cartilage element that is part of a manual digit mesenchyme." []
synonym: "fore limb digit phalanx cartilage condensation" EXACT []
synonym: "hand digit phalanx cartilage condensation" NARROW []
is_a: UBERON:0010701 ! phalanx cartilage element
is_a: UBERON:0015024 ! manual digit phalanx endochondral element
is_a: UBERON:0035128 ! manus cartilage element
relationship: develops_from UBERON:0010586 ! manual digit phalanx pre-cartilage condensation

[Term]
id: UBERON:0010688
name: skeleton of manual acropodium
def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified]." []
synonym: "all phalanges in forelimb autopod" EXACT []
synonym: "anterior acropodium" RELATED []
synonym: "anterior acropodium skeleton" EXACT []
synonym: "fore acropodium skeleton" EXACT []
synonym: "hand digit skeleton" EXACT []
synonym: "manual digit skeleton" EXACT []
synonym: "manual phalanges" EXACT []
synonym: "phalanges of hand" EXACT []
synonym: "phalanges of manus" EXACT []
synonym: "set of manual phalanges" EXACT []
synonym: "set of phalanges of hand" EXACT []
synonym: "set of phalanges of manus" EXACT []
is_a: UBERON:0010543 ! acropodial skeleton
intersection_of: UBERON:0010543 ! acropodial skeleton
intersection_of: part_of UBERON:0002398 ! manus
disjoint_from: UBERON:0010696 ! skeleton of pedal acropodium
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0012151 ! skeleton of manual digitopodium

[Term]
id: UBERON:0010696
name: skeleton of pedal acropodium
def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm]." []
synonym: "all phalanges in hindlimb autopod" EXACT []
synonym: "foot digit skeleton" EXACT []
synonym: "hind acropodium skeleton" EXACT []
synonym: "pedal phalanges" EXACT []
synonym: "phalanges of foot" EXACT []
synonym: "phalanges of pes" EXACT []
synonym: "posterior acropodium" RELATED []
synonym: "posterior acropodium skeleton" EXACT []
synonym: "set of pedal phalanges" EXACT []
synonym: "set of phalanges of foot" EXACT []
synonym: "set of phalanges of pes" EXACT []
is_a: UBERON:0010543 ! acropodial skeleton
intersection_of: UBERON:0010543 ! acropodial skeleton
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012152 ! skeleton of pedal digitopodium

[Term]
id: UBERON:0010700
name: phalanx pre-cartilage condensation
is_a: UBERON:0010882 ! limb bone pre-cartilage condensation
is_a: UBERON:0015023 ! phalanx endochondral element
relationship: part_of UBERON:0010702 ! digit mesenchyme

[Term]
id: UBERON:0010701
name: phalanx cartilage element
is_a: UBERON:0015023 ! phalanx endochondral element
is_a: UBERON:0015064 ! autopod cartilage
relationship: develops_from UBERON:0010700 ! phalanx pre-cartilage condensation

[Term]
id: UBERON:0010702
name: digit mesenchyme
def: "Mesenchyme of the digit region." []
synonym: "digital ray" RELATED []
is_a: UBERON:0009749 ! limb mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0002544 ! digit
relationship: part_of UBERON:0002544 ! digit

[Term]
id: UBERON:0010707
name: appendage girdle complex
def: "An organism subdivision that includes both an appendage and its accociated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." []
synonym: "appendage complex" EXACT []
synonym: "appendage-girdle complex" EXACT []
synonym: "appendage/girdle complex" EXACT []
synonym: "girdle plus limb or fin" EXACT []
synonym: "limb" RELATED []
is_a: UBERON:0000475 ! organism subdivision
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0010708
name: pectoral complex
def: "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." []
synonym: "pectoral appendage/girdle complex" EXACT []
synonym: "pectoral girdle plus anterior limb or fin" EXACT []
synonym: "pectoral girdle plus pectoral limb or fin" EXACT []
synonym: "upper limb" RELATED []
synonym: "upper limb and pectoral girdle" RELATED []
synonym: "upper limb and shoulder" RELATED []
is_a: UBERON:0010707 ! appendage girdle complex
intersection_of: UBERON:0010707 ! appendage girdle complex
intersection_of: has_part UBERON:0001421 ! pectoral girdle region
relationship: has_part UBERON:0001421 ! pectoral girdle region

[Term]
id: UBERON:0010709
name: pelvic complex
def: "Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle." []
synonym: "lower limb" RELATED []
synonym: "lower limb and pelvic girdle" RELATED []
synonym: "lower limb and pelvis" RELATED []
synonym: "pelvic appendage/girdle complex" EXACT []
synonym: "pelvic girdle plus pelvic limb or fin" EXACT []
synonym: "pelvic girdle plus posterior limb or fin" EXACT []
is_a: UBERON:0010707 ! appendage girdle complex
intersection_of: UBERON:0010707 ! appendage girdle complex
intersection_of: has_part UBERON:0001271 ! pelvic girdle region
relationship: has_part UBERON:0001271 ! pelvic girdle region

[Term]
id: UBERON:0010712
name: limb skeleton subdivision
def: "Skeletal subdivision that is a segment of the limb skeleton." []
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0010719
name: girdle skeleton
def: "The subdivision of the skeleton of either the pectoral or pelvic girdle." []
synonym: "skeleton of girdle" EXACT []
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0007823 ! appendage girdle region

[Term]
id: UBERON:0010740
name: bone of appendage girdle complex
def: "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." []
synonym: "bone of extended limb/fin region" RELATED []
synonym: "limb bone" RELATED []
is_a: UBERON:0001474 ! bone element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0010707 ! appendage girdle complex
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0010707 ! appendage girdle complex

[Term]
id: UBERON:0010741
name: bone of pectoral complex
def: "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." []
synonym: "bone of forelimb or pectoral fin or pectoral girdle" RELATED []
synonym: "forelimb bone" RELATED []
synonym: "wing bone" NARROW []
is_a: UBERON:0010740 ! bone of appendage girdle complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0010708 ! pectoral complex
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0010742
name: bone of pelvic complex
def: "A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle." []
synonym: "hindlimb bone" RELATED []
is_a: UBERON:0010740 ! bone of appendage girdle complex
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0010709 ! pelvic complex
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0010743
name: meningeal cluster
def: "The collection of all meningeal layers that line a central nervous system." []
synonym: "cerebral meninges" EXACT []
synonym: "cluster of meninges" EXACT []
synonym: "meninges" EXACT []
is_a: UBERON:0034925 ! anatomical collection
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0010748
name: lymph node follicle
def: "A lymphoid follicle that is part of a lymph node." []
synonym: "follicle of lymph node" EXACT []
is_a: UBERON:0000444 ! lymphoid follicle
intersection_of: UBERON:0000444 ! lymphoid follicle
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0002006 ! cortex of lymph node

[Term]
id: UBERON:0010753
name: lymph node secondary follicle
def: "A secondary follicle that is located in a lymph node" []
is_a: UBERON:0001745 ! secondary nodular lymphoid tissue
is_a: UBERON:0010748 ! lymph node follicle
intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: develops_from UBERON:0010395 ! lymph node primary follicle
relationship: part_of UBERON:0000029 ! lymph node

[Term]
id: UBERON:0010754
name: germinal center
def: "A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center." []
synonym: "central zone of follice" EXACT []
synonym: "light zone of follicle" EXACT []
synonym: "lymhpoid nodule" RELATED []
synonym: "nodule" RELATED []
synonym: "reaction center of follicle" EXACT []
is_a: UBERON:0001744 ! lymphoid tissue
relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue

[Term]
id: UBERON:0010758
name: subdivision of organism along appendicular axis
def: "A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg." []
synonym: "appendage segment" EXACT []
synonym: "appendicular segment" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0000026 ! appendage

[Term]
id: UBERON:0010881
name: limb cartilage element
def: "A skeletal element that is part of a limb and composed of cartilage tissue." []
is_a: UBERON:0007844 ! cartilage element
is_a: UBERON:0015061 ! limb endochondral element
relationship: develops_from UBERON:0010882 ! limb bone pre-cartilage condensation

[Term]
id: UBERON:0010882
name: limb bone pre-cartilage condensation
def: "A skeletal element that is part of a limb and composed of pre-cartilage tissue." []
is_a: UBERON:0015061 ! limb endochondral element

[Term]
id: UBERON:0010883
name: forelimb cartilage element
def: "A cartilaginous condensation that has the potential to develop into a forelimb bone." []
synonym: "forelimb wing cartilaginous condensation" NARROW []
synonym: "wing cartilaginous condensation" NARROW []
is_a: UBERON:0010881 ! limb cartilage element
is_a: UBERON:0015021 ! forelimb endochondral element
relationship: develops_from UBERON:0010884 ! forelimb bone pre-cartilage condensation

[Term]
id: UBERON:0010884
name: forelimb bone pre-cartilage condensation
def: "A pre-cartilage condensation that has the potential to develop into a forelimb bone." []
synonym: "wing bone pre-cartilage condensation" NARROW []
is_a: UBERON:0010882 ! limb bone pre-cartilage condensation
is_a: UBERON:0015021 ! forelimb endochondral element

[Term]
id: UBERON:0010885
name: hindlimb cartilage element
def: "A cartilaginous condensation that has the potential to develop into a hindlimb bone." []
synonym: "hindlimb cartilage condensation" EXACT []
is_a: UBERON:0007844 ! cartilage element
is_a: UBERON:0015022 ! hindlimb endochondral element
relationship: develops_from UBERON:0010886 ! hindlimb pre-cartilage condensation

[Term]
id: UBERON:0010886
name: hindlimb pre-cartilage condensation
def: "A pre-cartilage condensation that has the potential to develop into a hindlimb bone." []
synonym: "hindlimb pre-cartilage condensation" EXACT []
is_a: UBERON:0015022 ! hindlimb endochondral element

[Term]
id: UBERON:0010890
name: pelvic complex muscle
def: "Muscles of the pelvic girdle, hindlimb or pelvic fin." []
synonym: "lower limb muscle" RELATED []
synonym: "muscle of lower limb" RELATED []
synonym: "muscle of pelvic girdle and leg" RELATED []
synonym: "pelvic girdle and hind limb muscles" EXACT []
synonym: "pelvic girdle or hind limb muscle" NARROW []
synonym: "pelvic girdle or posterior limb muscle" NARROW []
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0010709 ! pelvic complex
relationship: part_of UBERON:0010709 ! pelvic complex
relationship: part_of UBERON:0014792 ! musculature of pelvic complex

[Term]
id: UBERON:0010891
name: pectoral complex muscle
def: "A muscle of a pectoral girdle, pectoral fin or anterior limb." []
synonym: "muscle of pectoral girdle and limb" RELATED []
synonym: "muscle of pectoral girdle and wing" NARROW []
synonym: "muscle of upper limb" NARROW []
synonym: "pectoral girdle and fore limb muscles" EXACT []
synonym: "upper limb muscle" NARROW []
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0010708 ! pectoral complex
relationship: part_of UBERON:0010708 ! pectoral complex
relationship: part_of UBERON:0014793 ! musculature of pectoral complex

[Term]
id: UBERON:0010899
name: synchronous hermaphroditic organism
def: "Hermaphroditic organism that produces both male and female gametes at the same time." []
synonym: "serially hermaphroditic organism" RELATED []
synonym: "simultaneous hermaphroditic organism" RELATED []
is_a: UBERON:0007197 ! hermaphroditic organism
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: has_part UBERON:0000473 ! testis
intersection_of: has_part UBERON:0000992 ! female gonad
relationship: has_part UBERON:0000473 ! testis
relationship: has_part UBERON:0000992 ! female gonad

[Term]
id: UBERON:0010912
name: subdivision of skeleton
def: "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." []
synonym: "skeletal subdivision" EXACT []
synonym: "subdivision of skeleton (in vivo)" RELATED []
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0000075 ! subdivision of skeletal system
relationship: part_of UBERON:0004288 ! skeleton

[Term]
id: UBERON:0010913
name: vertebral element
def: "Skeletal element that forms around the notochord and is part of the vertebral column." []
synonym: "vertebra element" EXACT []
synonym: "vertebra endochondral element" NARROW []
synonym: "vertebra skeletal element" BROAD []
synonym: "vertebral endochondral element" NARROW []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004765 ! skeletal element
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0001130 ! vertebral column

[Term]
id: UBERON:0010959
name: craniocervical muscle
def: "Any muscle organ that is part of either the head or the neck." []
synonym: "muscle of head and neck" RELATED []
synonym: "muscle of head or neck" EXACT []
is_a: UBERON:0014892 ! skeletal muscle organ
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0008229 ! craniocervical region musculature

[Term]
id: UBERON:0010963
name: trunk and cervical myotome group
is_a: UBERON:0003082 ! myotome
relationship: part_of UBERON:0005256 ! trunk mesenchyme

[Term]
id: UBERON:0010984
name: pectoral pre-muscle mass
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005865 ! pre-muscle condensation
relationship: develops_from UBERON:0010963 ! trunk and cervical myotome group
relationship: part_of UBERON:0008713 ! pectoral girdle and thoracic body wall skeletal muscle

[Term]
id: UBERON:0010996
name: articular cartilage of joint
def: "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." []
synonym: "articular cartilage" EXACT []
synonym: "cartilago articularis" EXACT []
synonym: "hyaline cartilage" RELATED []
synonym: "joint-associated cartilage" RELATED []
is_a: UBERON:0001994 ! hyaline cartilage tissue
relationship: part_of UBERON:0002217 ! synovial joint

[Term]
id: UBERON:0011004
name: pharyngeal arch cartilage
def: "A cartilage element that is part of a splanchnocranium." []
synonym: "pharyngeal arch cartilages" EXACT []
synonym: "splanchnocranium cartilage" EXACT []
is_a: UBERON:0003933 ! cranial cartilage
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0008895 ! splanchnocranium
relationship: develops_from UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0008895 ! splanchnocranium

[Term]
id: UBERON:0011088
name: ligament of knee joint
def: "A ligament that is part of a knee joint." []
synonym: "knee joint ligament" EXACT []
is_a: UBERON:0008846 ! skeletal ligament
intersection_of: UBERON:0000211 ! ligament
intersection_of: part_of UBERON:0001485 ! knee joint
relationship: part_of UBERON:0001485 ! knee joint

[Term]
id: UBERON:0011094
name: vertebra cartilage element
def: "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." []
synonym: "vertebral cartilage condensation" EXACT []
is_a: UBERON:0007844 ! cartilage element
is_a: UBERON:0010913 ! vertebral element
relationship: develops_from UBERON:0011095 ! vertebra pre-cartilage condensation

[Term]
id: UBERON:0011095
name: vertebra pre-cartilage condensation
def: "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." []
synonym: "vertebral pre-cartilage condensation" EXACT []
is_a: UBERON:0010913 ! vertebral element
relationship: develops_from UBERON:0003089 ! sclerotome

[Term]
id: UBERON:0011107
name: synovial joint of pelvic girdle
def: "A synovial joint that is part of a pelvic girdle region." []
synonym: "joint of pelvic girdle" EXACT []
synonym: "pelvic girdle joint" EXACT []
is_a: UBERON:0002217 ! synovial joint
is_a: UBERON:0008114 ! joint of girdle
intersection_of: UBERON:0002217 ! synovial joint
intersection_of: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0001271 ! pelvic girdle region

[Term]
id: UBERON:0011108
name: synovial joint of pectoral girdle
def: "A synovial joint that is part of a pectoral girdle region." []
synonym: "joint of shoulder girdle" EXACT []
synonym: "pectoral girdle joint" EXACT []
is_a: UBERON:0002217 ! synovial joint
is_a: UBERON:0008114 ! joint of girdle
intersection_of: UBERON:0002217 ! synovial joint
intersection_of: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0001421 ! pectoral girdle region

[Term]
id: UBERON:0011134
name: nonsynovial joint
def: "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." []
synonym: "solid joint" EXACT []
is_a: UBERON:0000982 ! skeletal joint

[Term]
id: UBERON:0011135
name: intervertebral cartilage
def: "A cartilage element that lies between two successive vertebral centra." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0007844 ! cartilage element
relationship: part_of UBERON:0001468 ! intervertebral joint

[Term]
id: UBERON:0011137
name: axial skeletal system
def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." []
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: has_part UBERON:0000982 ! skeletal joint
relationship: has_part UBERON:0005944 ! axial skeleton plus cranial skeleton

[Term]
id: UBERON:0011138
name: post-cranial axial skeletal system
def: "Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints." []
synonym: "axial skeletal system" BROAD []
is_a: UBERON:0000075 ! subdivision of skeletal system
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0003089 ! sclerotome

[Term]
id: UBERON:0011139
name: synovial limb joint
def: "Any synovial joint that is part of a (free) limb." []
synonym: "synovial joint of free limb segment" EXACT []
is_a: UBERON:0002217 ! synovial joint
is_a: UBERON:0003657 ! limb joint
intersection_of: UBERON:0002217 ! synovial joint
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:0011143
name: upper urinary tract
def: "Subdivision of urinary system which consists of the kidney and the ureters." []
is_a: UBERON:0000477 ! anatomical cluster
relationship: has_part UBERON:0000056 ! ureter
relationship: has_part UBERON:0002113 ! kidney
relationship: part_of UBERON:0001008 ! renal system

[Term]
id: UBERON:0011148
name: submucosal gland
def: "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." []
is_a: UBERON:0000414 ! mucous gland

[Term]
id: UBERON:0011156
name: facial skeleton
def: "Subdivision of skull that consists of the facial bones." []
synonym: "facial bone" RELATED []
synonym: "facial skeleton" EXACT []
synonym: "ossa facialia" RELATED []
synonym: "ossa faciei" RELATED []
synonym: "viscerocranium" RELATED []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011158 ! primary subdivision of skull
relationship: develops_from UBERON:0002342 ! neural crest
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0011158
name: primary subdivision of skull
def: "The skull can be divided into two: the neurocranium and the facial skeleton" []
synonym: "skull subdivision" EXACT []
synonym: "subdivision of skull" EXACT []
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: part_of UBERON:0003129 ! skull

[Term]
id: UBERON:0011159
name: primary subdivision of cranial skeletal system
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: part_of UBERON:0010323 ! cranial skeletal system

[Term]
id: UBERON:0011164
name: neurocranium bone
def: "A bone that is part of a neurocranium [Automatically generated definition]." []
synonym: "chondrocranium bone" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004766 ! cranial bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0001703 ! neurocranium
relationship: part_of UBERON:0001703 ! neurocranium

[Term]
id: UBERON:0011184
name: epithelium of crypt of Lieberkuhn
def: "An epithelium that is part of a crypt of Lieberkuhn." []
synonym: "crypt epithelium" BROAD []
synonym: "intestinal crypt epithelium" EXACT []
is_a: UBERON:0001277 ! intestinal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn
relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn

[Term]
id: UBERON:0011185
name: gastrointestinal sphincter
def: "A sphincter muscle that is part of the gastrointestinal system" []
is_a: UBERON:0004590 ! sphincter muscle
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system

[Term]
id: UBERON:0011189
name: lamina propria of large intestine
def: "A lamina propria that is part of a large intestine." []
synonym: "lamina propria of mucosa of large intestine" EXACT []
synonym: "large intestinal lamina propria" EXACT []
synonym: "large intestine lamina propria" EXACT []
is_a: UBERON:0004780 ! gastrointestinal system lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine
relationship: part_of UBERON:0001207 ! mucosa of large intestine

[Term]
id: UBERON:0011197
name: parathyroid epithelium
def: "An epithelium that is part of a parathyroid gland." []
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0006799 ! glandular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: develops_from UBERON:0004117 ! pharyngeal pouch
relationship: part_of UBERON:0001132 ! parathyroid gland

[Term]
id: UBERON:0011198
name: muscle layer of large intestine
def: "A muscle layer that is part of a large intestine." []
synonym: "muscular coat of large intestine" EXACT []
synonym: "muscular layer of large intestine" EXACT []
synonym: "muscularis externa of large intestine" EXACT []
synonym: "tunica muscularis intestini crassi" EXACT []
is_a: UBERON:0012367 ! muscle layer of intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001169 ! wall of large intestine

[Term]
id: UBERON:0011201
name: muscle layer of small intestine
def: "A muscle layer that is part of a small intestine." []
synonym: "muscular coat of small intestine" EXACT []
synonym: "muscular layer of small intestine" EXACT []
synonym: "muscularis externa of small intestine" EXACT []
synonym: "small intestine muscularis propria" EXACT []
synonym: "tunica muscularis (intestinum tenue)" EXACT []
synonym: "tunica muscularis intestini tenuis" EXACT []
is_a: UBERON:0012367 ! muscle layer of intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001168 ! wall of small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: UBERON:0011215
name: central nervous system cell part cluster
def: "A multi cell part structure that is part of a central nervous system." []
synonym: "cell part cluster of neuraxis" EXACT []
synonym: "neuraxis layer" EXACT []
is_a: UBERON:0005162 ! multi cell part structure
intersection_of: UBERON:0005162 ! multi cell part structure
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: UBERON:0011216
name: organ system subdivision
def: "A subdivision of an anatomical system." []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000467 ! anatomical system

[Term]
id: UBERON:0011222
name: intra-ocular muscle
synonym: "intrinsic muscle of eyeball" EXACT []
synonym: "intrinsic ocular muscle" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004277 ! eye muscle
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0003386 ! smooth muscle of eye

[Term]
id: UBERON:0011249
name: appendicular skeletal system
def: "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." []
is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: has_part UBERON:0000982 ! skeletal joint
relationship: has_part UBERON:0002091 ! appendicular skeleton

[Term]
id: UBERON:0011250
name: autopod bone
def: "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." []
is_a: UBERON:0002428 ! limb bone
is_a: UBERON:0015063 ! autopod endochondral element
relationship: develops_from UBERON:0015064 ! autopod cartilage

[Term]
id: UBERON:0011270
name: dorsal trunk
def: "The part of the trunk that is in the dorsum[cjm]." []
synonym: "back of trunk" EXACT []
synonym: "dorsal part of trunk" EXACT []
synonym: "dorsum of trunk" EXACT []
synonym: "trunk back" EXACT []
is_a: UBERON:0009569 ! subdivision of trunk
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0011272
name: embryonic skin basal layer
synonym: "basal cell layer of skin" RELATED []
synonym: "outer epithelium of body" RELATED []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:0011289
name: pharyngobasilar fascia
def: "The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis." []
synonym: "pharyngeal aponeurosis" EXACT []
synonym: "pharyngeal aponeurosis" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0006614 ! aponeurosis
intersection_of: UBERON:0006614 ! aponeurosis
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0011298
name: submucosa of uterine tube
def: "The submucous layer of the wall of the uterine tube." []
synonym: "submucosa of fallopian tube" EXACT []
synonym: "submucous layer of uterine tube" RELATED []
synonym: "tela submucosa tubae uterinae" EXACT []
synonym: "uterine submucosa" RELATED []
is_a: UBERON:0000009 ! submucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0011299
name: white matter of telencephalon
def: "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum." []
synonym: "predominantly white regional part of telencephalon" EXACT []
synonym: "telencephalic tract/commissure" EXACT []
synonym: "telencephalic tracts" NARROW []
synonym: "telencephalic white matter" EXACT []
is_a: UBERON:0019261 ! white matter of forebrain
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0011300
name: gray matter of telencephalon
def: "A portion of gray matter that is part of a telencephalon." []
synonym: "predominantly gray regional part of telencephalon" EXACT []
is_a: UBERON:0019264 ! gray matter of forebrain
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon

[Term]
id: UBERON:0011362
name: cranial blood vasculature
def: "A blood vasculature that is part of a head." []
synonym: "cranial blood vessel" EXACT []
synonym: "cranial blood vessels" RELATED []
synonym: "set of blood vessels of head" EXACT []
is_a: UBERON:0002200 ! vasculature of head
is_a: UBERON:0004537 ! blood vasculature
intersection_of: UBERON:0004537 ! blood vasculature
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0011363
name: cranial lymph vasculature
def: "A lymph vasculature that is part of a head." []
synonym: "cranial lymph vessel" EXACT []
synonym: "cranial lymph vessels" RELATED []
synonym: "set of cranial lymphatic vessels" RELATED []
synonym: "set of lymphatic vessels of head" EXACT []
is_a: UBERON:0002200 ! vasculature of head
is_a: UBERON:0004536 ! lymph vasculature
intersection_of: UBERON:0004536 ! lymph vasculature
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0011374
name: prepuce
def: "A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present." []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0034929 ! external soft tissue zone
relationship: has_part UBERON:0000014 ! zone of skin
relationship: has_part UBERON:0000344 ! mucosa
relationship: part_of UBERON:0005156 ! reproductive structure

[Term]
id: UBERON:0011582
name: paired limb/fin skeleton
def: "The collection of all skeletal elements in an individual limb or fin." []
synonym: "limb/fin skeleton" EXACT []
synonym: "skeletal parts of limb/fin" EXACT []
synonym: "skeleton of limb/fin" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0004708 ! paired limb/fin

[Term]
id: UBERON:0011585
name: cell condensation
def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0011588
name: pre-enamel
def: "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." []
synonym: "pre-enamel tissue" EXACT []
synonym: "preenamel tissue" EXACT []
is_a: UBERON:0010365 ! odontoid tissue

[Term]
id: UBERON:0011595
name: jaw region
def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000475 ! organism subdivision
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0000165 ! mouth

[Term]
id: UBERON:0011602
name: gingiva of lower jaw
def: "A gingiva that is part of a lower jaw region." []
synonym: "gum of lower jaw" EXACT []
synonym: "gum of mandible" EXACT []
synonym: "lower gingiva" EXACT []
synonym: "lower gum" RELATED []
synonym: "lower jaw gingiva" EXACT []
synonym: "lower jaw gum" RELATED []
synonym: "mandibular gum" RELATED []
is_a: UBERON:0001828 ! gingiva
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001828 ! gingiva
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: part_of UBERON:0001710 ! lower jaw region

[Term]
id: UBERON:0011642
name: oral epithelium from ectoderm
def: "An epithelium that develops_from a ectoderm and is part of a oral epithelium." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0002424 ! oral epithelium
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0002424 ! oral epithelium
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: develops_from UBERON:0009479 ! ectoderm of buccopharyngeal membrane
relationship: part_of UBERON:0002424 ! oral epithelium

[Term]
id: UBERON:0011676
name: subdivision of organism along main body axis
def: "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." []
synonym: "axial subdivision of organism" EXACT []
synonym: "body segment" RELATED []
synonym: "main body segment" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0013701 ! main body axis

[Term]
id: UBERON:0011695
name: embryonic cardiovascular system
def: "A cardiovascular system that is part of a conceptus." []
synonym: "conceptus cardiovascular system" EXACT []
synonym: "embryonic circulatory system" RELATED []
synonym: "fetal circulatory system" RELATED []
is_a: UBERON:0004535 ! cardiovascular system
intersection_of: UBERON:0004535 ! cardiovascular system
intersection_of: part_of UBERON:0004716 ! conceptus
relationship: part_of UBERON:0004716 ! conceptus

[Term]
id: UBERON:0011777
name: nucleus of spinal cord
def: "A neural nucleus that is part of the spinal cord." []
synonym: "spinal cord nucleus" EXACT []
is_a: UBERON:0000125 ! neural nucleus
intersection_of: UBERON:0000125 ! neural nucleus
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0011779
name: nerve of head region
def: "A nerve that is part of a head." []
synonym: "cephalic nerve" RELATED []
synonym: "head nerve" RELATED []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0011814
name: non-neurogenic ectodermal placode
def: "Ectodermal placode that does not develop into a component of the nervous system." []
is_a: UBERON:0005085 ! ectodermal placode

[Term]
id: UBERON:0011817
name: follicle placode
is_a: UBERON:0011814 ! non-neurogenic ectodermal placode

[Term]
id: UBERON:0011821
name: irregular connective tissue
def: "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." []
is_a: UBERON:0002384 ! connective tissue

[Term]
id: UBERON:0011822
name: dense irregular connective tissue
def: "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." []
synonym: "irregular dense connective tissue" EXACT []
synonym: "typus irregularis (textus connectivus collagenosus compactus)" EXACT []
is_a: UBERON:0011821 ! irregular connective tissue
is_a: UBERON:0011823 ! dense connective tissue

[Term]
id: UBERON:0011823
name: dense connective tissue
def: "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets" []
is_a: UBERON:0002384 ! connective tissue
disjoint_from: UBERON:0011825 ! loose connective tissue

[Term]
id: UBERON:0011825
name: loose connective tissue
def: "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." []
synonym: "textus connectivus collagenosus laxus" EXACT []
synonym: "textus connectivus laxus" EXACT []
is_a: UBERON:0011821 ! irregular connective tissue

[Term]
id: UBERON:0011845
name: duct of sebaceous gland
def: "A duct that is part of a sebaceous gland." []
synonym: "sebaceous gland duct" EXACT []
is_a: UBERON:0000058 ! duct
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0001821 ! sebaceous gland

[Term]
id: UBERON:0011846
name: acinus of sebaceous gland
def: "An acinus that is part of a sebaceous gland." []
synonym: "sebaceous gland acinus" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0001821 ! sebaceous gland

[Term]
id: UBERON:0011850
name: acinus of salivary gland
def: "An acinus that is part of a salivary gland." []
synonym: "salivary gland acinus" EXACT []
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland

[Term]
id: UBERON:0011856
name: acinus of lactiferous gland
def: "An acinus that is part of a mammary gland." []
synonym: "lactiferous gland acinus" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001912 ! lobule of mammary gland

[Term]
id: UBERON:0011857
name: acinus of lacrimal gland
def: "An acinus that is part of a lacrimal gland." []
synonym: "lacrimal gland acinus" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0001817 ! lacrimal gland
relationship: part_of UBERON:0001817 ! lacrimal gland

[Term]
id: UBERON:0011858
name: acinus of exocrine gland
def: "An acinus that is part of a exocrine gland." []
synonym: "exocrine gland acinus" EXACT []
is_a: UBERON:0009842 ! glandular acinus
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0002365 ! exocrine gland
relationship: part_of UBERON:0002365 ! exocrine gland

[Term]
id: UBERON:0011860
name: collection of collagen fibrils
is_a: UBERON:0000476 ! acellular anatomical structure

[Term]
id: UBERON:0011861
name: aorta collagen fibril
def: "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity" []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0011860 ! collection of collagen fibrils
intersection_of: UBERON:0011860 ! collection of collagen fibrils
intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia
relationship: part_of UBERON:0004664 ! aorta tunica adventitia

[Term]
id: UBERON:0011862
name: pulmonary collagen fibril
def: "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity" []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011860 ! collection of collagen fibrils
intersection_of: UBERON:0011860 ! collection of collagen fibrils
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0011863
name: bone collagen fibril
def: "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" []
is_a: UBERON:0011860 ! collection of collagen fibrils
intersection_of: UBERON:0011860 ! collection of collagen fibrils
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0011864
name: tendon collagen fibril
def: "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" []
is_a: UBERON:0011860 ! collection of collagen fibrils
intersection_of: UBERON:0011860 ! collection of collagen fibrils
intersection_of: part_of UBERON:0000043 ! tendon
relationship: part_of UBERON:0000043 ! tendon

[Term]
id: UBERON:0011865
name: corneal stroma collagen fibril
def: "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity" []
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011860 ! collection of collagen fibrils
intersection_of: UBERON:0011860 ! collection of collagen fibrils
intersection_of: part_of UBERON:0001777 ! substantia propria of cornea
relationship: part_of UBERON:0001777 ! substantia propria of cornea

[Term]
id: UBERON:0011878
name: muscle layer of esophagus
def: "A muscle layer that is part of a wall of esophagus." []
synonym: "muscle coat of esophagus" EXACT []
synonym: "muscular coat of oesophagus" EXACT []
synonym: "muscular layer of oesophagus" EXACT []
synonym: "tela muscularis (oesophagus)" EXACT []
synonym: "tunica muscularis esophagi" EXACT []
synonym: "tunica muscularis oesophageae" EXACT []
is_a: UBERON:0018261 ! muscular coat of digestive tract
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: has_part UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001096 ! wall of esophagus

[Term]
id: UBERON:0011892
name: anterior uvea
def: "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." []
synonym: "anterior part of uveal tract" EXACT []
synonym: "anterior uveal tract" EXACT []
synonym: "anterior vascular layer of the eyeball" EXACT []
synonym: "anterior vascular tunic of the eye" EXACT []
synonym: "ciliary body and iris" RELATED []
synonym: "Haller tunica vascula" EXACT []
synonym: "tunica vasculosa bulbosa" EXACT []
synonym: "vasculosa oculi" RELATED []
synonym: "ventral uveal tract" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: has_part UBERON:0001769 ! iris
relationship: has_part UBERON:0001775 ! ciliary body
relationship: part_of UBERON:0001768 ! uvea
relationship: part_of UBERON:0001801 ! anterior segment of eyeball

[Term]
id: UBERON:0011894
name: lumen of vagina
def: "A organ cavity that is part of a vagina." []
synonym: "vaginal lumen" EXACT []
is_a: UBERON:0002558 ! organ cavity
intersection_of: UBERON:0002558 ! organ cavity
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0011919
name: yolk sac blood island
def: "masses of developing blood cells attached to endothelium in the yolk sac" []
synonym: "visceral yolk sac blood island" EXACT []
synonym: "yolk sac blood islands" EXACT []
is_a: UBERON:0003061 ! blood island
intersection_of: UBERON:0003061 ! blood island
intersection_of: part_of UBERON:0003316 ! mesenchyme of yolk sac
relationship: develops_from UBERON:0003316 ! mesenchyme of yolk sac
relationship: part_of UBERON:0003316 ! mesenchyme of yolk sac

[Term]
id: UBERON:0011921
name: connecting stalk blood islands
synonym: "blood island of umbilical vesicle" EXACT []
synonym: "insula sanguinea vesiculae umbilicalis" EXACT []
is_a: UBERON:0007503 ! epithelial vesicle
is_a: UBERON:0010303 ! extraembryonic epithelium
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0005667 ! connecting stalk mesoderm
relationship: part_of UBERON:0002331 ! umbilical cord

[Term]
id: UBERON:0011922
name: cochlear basement membrane
def: "The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes" []
synonym: "basement membrane of cochlear labyrinth" EXACT []
synonym: "cochlea basement membrane" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005769 ! basement membrane of epithelium
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0002499 ! cochlear labyrinth
relationship: part_of UBERON:0002499 ! cochlear labyrinth

[Term]
id: UBERON:0011931
name: nasal hair
def: "Hair in the nose" []
synonym: "hair of nose" EXACT []
synonym: "hair of vestibular part of nose" EXACT []
synonym: "nose hair" EXACT []
is_a: UBERON:0010171 ! strand of hair of face
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0000004 ! nose

[Term]
id: UBERON:0011932
name: pilosebaceous unit
def: "An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle" []
synonym: "fabrica pilosebacea" EXACT []
synonym: "pilo-sebaceous apparatus" EXACT []
synonym: "pilo-sebaceous unit" EXACT []
synonym: "pilosebaceous apparatus" EXACT []
synonym: "pilosebaceous gland" RELATED []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0001821 ! sebaceous gland
relationship: has_part UBERON:0002033 ! arrector muscle of hair
relationship: has_part UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0006003 ! integumentary adnexa

[Term]
id: UBERON:0011953
name: stomach glandular region
def: "A region of the stomach that is lined with glandular epithelium." []
synonym: "glandular stomach" RELATED []
is_a: UBERON:0009034 ! stomach region
intersection_of: UBERON:0009034 ! stomach region
intersection_of: has_part UBERON:0006924 ! stomach glandular epithelium
relationship: has_part UBERON:0006924 ! stomach glandular epithelium

[Term]
id: UBERON:0011997
name: coelom
def: "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." []
synonym: "coelem" RELATED []
synonym: "coelomic cavity" RELATED []
synonym: "enterocoelom" NARROW []
synonym: "haemocoelom" NARROW []
synonym: "schizocoelom" NARROW []
is_a: UBERON:0000481 ! multi-tissue structure

[Term]
id: UBERON:0012069
name: epithelium-associated lymphoid tissue
is_a: UBERON:0001744 ! lymphoid tissue

[Term]
id: UBERON:0012125
name: dermatological-muscosal system
def: "Anatomical system that consists of the integumental system plus all mucosae and submucosae." []
synonym: "dermatological system" RELATED []
is_a: UBERON:0000467 ! anatomical system
relationship: has_part UBERON:0000009 ! submucosa
relationship: has_part UBERON:0000344 ! mucosa
relationship: has_part UBERON:0002072 ! hypodermis
relationship: has_part UBERON:0002097 ! skin of body

[Term]
id: UBERON:0012139
name: segment of autopod
is_a: UBERON:0002529 ! limb segment
relationship: part_of UBERON:0002470 ! autopod region

[Term]
id: UBERON:0012140
name: digitopodium region
def: "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." []
synonym: "acropodium (Wagner)" RELATED []
is_a: UBERON:0012139 ! segment of autopod

[Term]
id: UBERON:0012141
name: manual digitopodium region
def: "A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region." []
is_a: UBERON:0005451 ! segment of manus
is_a: UBERON:0012140 ! digitopodium region
intersection_of: UBERON:0012140 ! digitopodium region
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0012142
name: pedal digitopodium region
def: "A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region." []
is_a: UBERON:0005445 ! segment of pes
is_a: UBERON:0012140 ! digitopodium region
intersection_of: UBERON:0012140 ! digitopodium region
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0012150
name: skeleton of digitopodium
def: "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." []
synonym: "digitopodium" RELATED []
synonym: "skeleton of digits" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010712 ! limb skeleton subdivision
relationship: part_of UBERON:0006717 ! autopodial skeleton
relationship: part_of UBERON:0012140 ! digitopodium region

[Term]
id: UBERON:0012151
name: skeleton of manual digitopodium
def: "A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton." []
synonym: "manual digitopodium" RELATED []
is_a: UBERON:0012150 ! skeleton of digitopodium
intersection_of: UBERON:0012150 ! skeleton of digitopodium
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0001442 ! skeleton of manus
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0012141 ! manual digitopodium region

[Term]
id: UBERON:0012152
name: skeleton of pedal digitopodium
def: "A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton." []
synonym: "pedal digitopodium" RELATED []
is_a: UBERON:0012150 ! skeleton of digitopodium
intersection_of: UBERON:0012150 ! skeleton of digitopodium
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0001445 ! skeleton of pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012142 ! pedal digitopodium region

[Term]
id: UBERON:0012168
name: umbilical cord blood
def: "blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." []
synonym: "cord blood" RELATED []
synonym: "fetal blood" RELATED []
synonym: "umbilical cord blood" RELATED []
is_a: UBERON:0000178 ! blood
relationship: part_of UBERON:0000323 ! late embryo

[Term]
id: UBERON:0012175
name: acoustico-facial VII-VIII ganglion complex
synonym: "acousticofacial ganglion" EXACT []
synonym: "facio-acoustic ganglion" EXACT []
synonym: "facio-acoustic ganglion complex" RELATED []
synonym: "facio-acoustic ganglion complex VII-VIII" EXACT []
synonym: "facio-acoustic VII-VIII ganglion complex" RELATED []
is_a: UBERON:0001714 ! cranial ganglion
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: develops_from UBERON:0006232 ! facio-acoustic VII-VIII preganglion complex

[Term]
id: UBERON:0012180
name: head or neck skin
def: "A zone of skin that is part of a craniocervical region." []
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0007811 ! craniocervical region
relationship: part_of UBERON:0007811 ! craniocervical region

[Term]
id: UBERON:0012239
name: urinary bladder vasculature
def: "network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]" []
synonym: "bladder vasculature" EXACT []
synonym: "blood vessel of bladder" RELATED []
synonym: "blood vessels of bladder" EXACT []
synonym: "set of urinary bladder blood vessels" EXACT []
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder

[Term]
id: UBERON:0012247
name: cervical gland
def: "mucus-secreting glands in the mucosa of the uterine cervix" []
synonym: "glandulae cervicales" EXACT []
is_a: UBERON:0002451 ! endometrial gland
intersection_of: UBERON:0002365 ! exocrine gland
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0012248 ! cervical mucosa

[Term]
id: UBERON:0012248
name: cervical mucosa
def: "Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing." []
is_a: UBERON:0001295 ! endometrium
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix

[Term]
id: UBERON:0012250
name: cervix glandular epithelium
def: "A glandular epithelium that is part of a uterine cervix." []
synonym: "cervix columnar epithelium" RELATED []
is_a: UBERON:0004801 ! cervix epithelium
is_a: UBERON:0006799 ! glandular epithelium
intersection_of: UBERON:0006799 ! glandular epithelium
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix

[Term]
id: UBERON:0012252
name: endocervical epithelium
def: "The glandular epithelium that lines the endocervix." []
synonym: "endocervical glandular epithelium" EXACT []
is_a: UBERON:0012250 ! cervix glandular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000458 ! endocervix
relationship: part_of UBERON:0000458 ! endocervix

[Term]
id: UBERON:0012274
name: columnar epithelium
def: "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]" []
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0012275
name: meso-epithelium
def: "Epithelium that derives from the mesoderm. [Automatically generated definition]." []
synonym: "mesoderm-derived epithelium" EXACT []
synonym: "mesoepithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000483 ! epithelium
intersection_of: develops_from UBERON:0000926 ! mesoderm
relationship: develops_from UBERON:0000926 ! mesoderm

[Term]
id: UBERON:0012276
name: endometrium glandular epithelium
synonym: "glandular part of endometrium" EXACT []
synonym: "uterine glands" EXACT []
synonym: "uterine glands set" EXACT []
is_a: UBERON:0004811 ! endometrium epithelium
is_a: UBERON:0006929 ! glandular columnar epithelium
is_a: UBERON:0007589 ! ciliated columnar oviduct epithelium
intersection_of: UBERON:0006799 ! glandular epithelium
intersection_of: part_of UBERON:0004811 ! endometrium epithelium
relationship: part_of UBERON:0004811 ! endometrium epithelium

[Term]
id: UBERON:0012278
name: gland of nasal mucosa
def: "The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands." []
synonym: "glandula nasalis" EXACT []
synonym: "glandulae nasales" EXACT []
synonym: "nasal gland" BROAD []
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0002330 ! exocrine system

[Term]
id: UBERON:0012279
name: chromaffin paraganglion
def: "Small bodies containing chromaffin cells occurring outside of the adrenal medulla, most commonly near the sympathetic ganglia and in organs such as the kidney, liver, heart and gonads." []
synonym: "chromaffin body" RELATED []
synonym: "chromaffin paraganglia" RELATED []
synonym: "chromaffin paraganglion" RELATED []
synonym: "paraganglion" BROAD []
is_a: UBERON:0034978 ! paraganglion (generic)
relationship: part_of UBERON:0010074 ! chromaffin system

[Term]
id: UBERON:0012292
name: embryonic cloacal fold
def: "One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly" []
synonym: "cloacal fold" BROAD []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0012469 ! external anal region

[Term]
id: UBERON:0012299
name: mucosa of urethra
def: "A mucosa that is part of a urethra." []
synonym: "mucous membrane of urethra" EXACT []
synonym: "tunica mucosa urethrae" EXACT []
synonym: "urethral mucosa" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0012313
name: 1st arch maxillary ectoderm
synonym: "ectoderm of maxillary component" EXACT []
is_a: UBERON:0003258 ! endoderm of foregut
is_a: UBERON:0004814 ! upper respiratory tract epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0007238 ! 1st arch maxillary component

[Term]
id: UBERON:0012314
name: embryonic facial prominence
def: "One of five swellings formed during the development of the face" []
synonym: "embryonic facial process" RELATED []
synonym: "facial primordium" RELATED []
synonym: "primordium of face" RELATED []
is_a: UBERON:0005423 ! developing anatomical structure
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0012317
name: vagina orifice
def: "The vaginal orifice is a median slit below and behind the opening of the urethra; its size varies inversely with that of the hymen." []
synonym: "introitus" RELATED []
synonym: "introitus of vagina" RELATED []
synonym: "orifice of vagina" EXACT []
synonym: "ostium vaginae" EXACT []
synonym: "vaginal introitus" RELATED []
synonym: "vaginal opening" EXACT []
synonym: "vaginal orifice" EXACT []
is_a: UBERON:0000161 ! orifice
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0012330
name: nasal-associated lymphoid tissue
def: "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." []
synonym: "NALT" EXACT []
synonym: "naso-pharyngeal lymphoid tissue" EXACT []
is_a: UBERON:0001962 ! gut-associated lymphoid tissue
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx

[Term]
id: UBERON:0012332
name: broad ligament of uterus
def: "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis." []
synonym: "broad ligament" RELATED []
synonym: "broad uterine ligament" EXACT []
synonym: "ligamentum latum uteri" RELATED []
is_a: UBERON:0000211 ! ligament
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0002095 ! mesentery

[Term]
id: UBERON:0012344
name: holocrine gland
def: "any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen." []
is_a: UBERON:0002365 ! exocrine gland

[Term]
id: UBERON:0012354
name: acropodium region
def: "The segment of the autopod that is distal to the metapodial region and consists of the digits." []
synonym: "acropodial limb segment" EXACT []
synonym: "acropodial region" EXACT []
synonym: "acropodial segment of autopod" EXACT []
synonym: "set of digits" EXACT []
is_a: UBERON:0012139 ! segment of autopod
relationship: part_of UBERON:0012140 ! digitopodium region

[Term]
id: UBERON:0012355
name: manual acropodium region
def: "The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers)." []
synonym: "acropodial hindlimb segment" EXACT []
synonym: "acropodial region of manus" EXACT []
synonym: "acropodial segment of manus" EXACT []
synonym: "all fingers" EXACT []
synonym: "anterior acropodium" RELATED []
synonym: "anterior acropodium region" EXACT []
synonym: "anterior acropodium segment of limb" EXACT []
synonym: "digiti manus" EXACT []
synonym: "digits of hand" EXACT []
synonym: "fingers including thumb" EXACT []
synonym: "fingers set" EXACT []
synonym: "manual acropodium" RELATED []
synonym: "manual acropodium region" EXACT []
synonym: "manual acropodium segment of limb" EXACT []
synonym: "set of digits of hand" EXACT []
synonym: "set of fingers" EXACT []
is_a: UBERON:0005451 ! segment of manus
is_a: UBERON:0012354 ! acropodium region
intersection_of: UBERON:0012354 ! acropodium region
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0012141 ! manual digitopodium region

[Term]
id: UBERON:0012356
name: pedal acropodium region
def: "The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes)." []
synonym: "acropodial forelimb segment" EXACT []
synonym: "acropodial region of pes" EXACT []
synonym: "acropodial segment of pes" EXACT []
synonym: "all toes" EXACT []
synonym: "digits of foot" EXACT []
synonym: "pedal acropodium region" EXACT []
synonym: "set of toes" EXACT []
synonym: "toes" RELATED []
synonym: "toes set" EXACT []
is_a: UBERON:0005445 ! segment of pes
is_a: UBERON:0012354 ! acropodium region
intersection_of: UBERON:0012354 ! acropodium region
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012142 ! pedal digitopodium region

[Term]
id: UBERON:0012357
name: digitopodium bone
def: "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." []
synonym: "digit bone" RELATED []
is_a: UBERON:0011250 ! autopod bone
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0012140 ! digitopodium region
relationship: part_of UBERON:0012140 ! digitopodium region
relationship: part_of UBERON:0012150 ! skeleton of digitopodium

[Term]
id: UBERON:0012358
name: manual digitopodium bone
def: "A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton." []
synonym: "bone of forelimb digitopodium" EXACT []
is_a: UBERON:0005897 ! manus bone
is_a: UBERON:0012357 ! digitopodium bone
intersection_of: UBERON:0012357 ! digitopodium bone
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0012151 ! skeleton of manual digitopodium

[Term]
id: UBERON:0012359
name: pedal digitopodium bone
def: "A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton." []
synonym: "bone of hindlimb digitopodium" EXACT []
is_a: UBERON:0005899 ! pes bone
is_a: UBERON:0012357 ! digitopodium bone
intersection_of: UBERON:0012357 ! digitopodium bone
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012152 ! skeleton of pedal digitopodium

[Term]
id: UBERON:0012360
name: bone of jaw
def: "A bone element that is part of a jaw region." []
synonym: "jaw bone" EXACT []
is_a: UBERON:0003462 ! facial bone
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0011595 ! jaw region
relationship: part_of UBERON:0001708 ! jaw skeleton
relationship: part_of UBERON:0011595 ! jaw region

[Term]
id: UBERON:0012361
name: internal anal region
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0012367
name: muscle layer of intestine
def: "A muscle layer that is part of an intestine." []
synonym: "intestinal muscularis propria" EXACT []
synonym: "muscularis externa of intestine" EXACT []
synonym: "smooth muscle of intestine" RELATED []
is_a: UBERON:0018261 ! muscular coat of digestive tract
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 ! wall of intestine

[Term]
id: UBERON:0012377
name: muscle layer of jejunum
def: "A muscular coat that is part of a jejunum." []
synonym: "jejunal smooth muscle" RELATED []
synonym: "muscularis externa of jejunum" EXACT []
synonym: "muscularis propria of jejunum" RELATED []
synonym: "smooth muscle of jejunum" RELATED []
is_a: UBERON:0011201 ! muscle layer of small intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0012378
name: muscle layer of urinary bladder
def: "A muscular coat that is part of a urinary bladder." []
synonym: "bladder muscular coat" EXACT []
synonym: "muscle layer of urinary bladder" EXACT []
synonym: "muscular coat of bladder" EXACT []
synonym: "muscular coat of urinary bladder" EXACT []
synonym: "muscular layer of bladder" EXACT []
synonym: "muscular layer of urinary bladder" EXACT []
synonym: "tunica musculari vesicae" EXACT []
synonym: "tunica muscularis (vesica urinaria)" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: has_part UBERON:0004228 ! urinary bladder smooth muscle
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001256 ! wall of urinary bladder

[Term]
id: UBERON:0012416
name: respiratory system arterial smooth muscle
is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle
is_a: UBERON:0004695 ! arterial system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003643 ! respiratory system arterial blood vessel
relationship: part_of UBERON:0003643 ! respiratory system arterial blood vessel

[Term]
id: UBERON:0012418
name: respiratory system venous smooth muscle
def: "A smooth muscle tissue that is part of a respiratory system venous blood vessel." []
is_a: UBERON:0004696 ! venous system smooth muscle
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0003476 ! respiratory system venous blood vessel
relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel

[Term]
id: UBERON:0012423
name: layer of microvilli
def: "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]" []
synonym: "microvilli" RELATED []
synonym: "microvillus" RELATED []
is_a: UBERON:0005162 ! multi cell part structure

[Term]
id: UBERON:0012425
name: striated border microvillus layer
def: "A microvillus layer that is striated and found in the intestine." []
synonym: "striated border" RELATED []
is_a: UBERON:0012423 ! layer of microvilli
relationship: part_of UBERON:0000160 ! intestine

[Term]
id: UBERON:0012429
name: hemopoietic tissue
def: "Blood-forming tissue, consisting of reticular fibers and cells. Also known as hemopoietic tissue" []
synonym: "bone marrow tissue" NARROW []
synonym: "haemopoietic tissue" EXACT []
synonym: "hematopoietic tissue" EXACT []
synonym: "textus haemopoieticus" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0034769 ! lymphomyeloid tissue
relationship: part_of UBERON:0002390 ! hematopoietic system

[Term]
id: UBERON:0012430
name: tunica fibrosa of eyeball
def: "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." []
synonym: "corneosclera" RELATED []
synonym: "fibrous layer of eyeball" EXACT []
synonym: "fibrous tunic" RELATED []
synonym: "tunica fibrosa" BROAD []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0000964 ! cornea
relationship: has_part UBERON:0001773 ! sclera
relationship: part_of UBERON:0010230 ! eyeball of camera-type eye

[Term]
id: UBERON:0012441
name: endothelium of peritubular capillary
def: "A endothelium that is part of a peritubular capillary." []
synonym: "peritubular capillary endothelium" EXACT []
synonym: "peritubular endothelium" BROAD []
is_a: UBERON:0001915 ! endothelium of capillary
is_a: UBERON:0004819 ! kidney epithelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0005272 ! peritubular capillary
relationship: part_of UBERON:0005272 ! peritubular capillary

[Term]
id: UBERON:0012464
name: cloacal vent
def: "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." []
synonym: "cloacal opening" EXACT []
synonym: "cloacal orifice" RELATED []
synonym: "vent" RELATED []
is_a: UBERON:0000161 ! orifice
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012468
name: anal tooth
def: "Tooth-like structure that typically forms a ring surrounding the anus of some Holothuriidae" []
synonym: "anal teeth" EXACT []
synonym: "cloacal tooth" RELATED []
synonym: "perianal tooth" RELATED []
is_a: UBERON:0003913 ! tooth-like structure
intersection_of: UBERON:0003913 ! tooth-like structure
intersection_of: part_of UBERON:0001353 ! anal region
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0012469
name: external anal region
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0012475
name: skeleton of pectoral complex
def: "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." []
synonym: "bones of upper limb" RELATED []
synonym: "ossa membri superioris" RELATED []
synonym: "pectoral complex skeleton" RELATED []
synonym: "set of bones of upper limb" RELATED []
synonym: "skeleton of anterior limb/fin and girdle" RELATED []
synonym: "upper limb skeleton" RELATED []
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0012476
name: skeleton of pelvic complex
def: "The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle." []
synonym: "bones of lower limb" RELATED []
synonym: "lower limb skeleton" RELATED []
synonym: "ossa membri inferioris" RELATED []
synonym: "pelvic complex skeleton" RELATED []
synonym: "set of bones of lower limb" RELATED []
synonym: "skeleton of posterior limb/fin and girdle" RELATED []
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: part_of UBERON:0002091 ! appendicular skeleton
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0012478
name: cloacal gland
def: "A gland that is part of a cloaca." []
is_a: UBERON:0003408 ! gland of gut
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012480
name: cloacal mucosa
def: "A mucosa that is part of a cloaca [Automatically generated definition]." []
synonym: "cloaca mucosa" EXACT []
synonym: "cloaca mucosa of organ" EXACT []
synonym: "cloaca mucous membrane" EXACT []
synonym: "cloaca organ mucosa" EXACT []
synonym: "cloacal mucous membrane" EXACT []
synonym: "mucosa of cloaca" EXACT []
synonym: "mucosa of organ of cloaca" EXACT []
synonym: "mucous membrane of cloaca" EXACT []
synonym: "organ mucosa of cloaca" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012481
name: cloacal epithelium
def: "An epithelium that is part of a cloaca." []
synonym: "cloacal endoderm" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003929 ! digestive tract epithelium
is_a: UBERON:0005911 ! endo-epithelium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: develops_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012482
name: submucosa of cloaca
def: "A submucosa that is part of a cloaca [Automatically generated definition]." []
synonym: "cloaca submucosa" EXACT []
synonym: "cloacal submucosa" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0018257 ! submucosa of digestive tract
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012483
name: serosa of cloaca
def: "A serous membrane that is part of a cloaca [Automatically generated definition]." []
synonym: "cloaca serosa" EXACT []
synonym: "cloaca serous membrane" EXACT []
synonym: "cloacal serosa" EXACT []
synonym: "serous membrane of cloaca" EXACT []
synonym: "visceral peritoneum of cloaca" EXACT []
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012485
name: cloacal villus
synonym: "cloacal villi" EXACT []
is_a: UBERON:0012423 ! layer of microvilli
intersection_of: UBERON:0012423 ! layer of microvilli
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012486
name: muscle layer of cloaca
def: "A muscular coat that is part of a cloaca." []
synonym: "muscularis externa of cloaca" EXACT []
synonym: "smooth muscle of cloaca" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0018261 ! muscular coat of digestive tract
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0012487
name: vaginal sphincter
def: "A sphincter muscle that is part of a vagina." []
synonym: "sphincter of vagina" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004590 ! sphincter muscle
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina

[Term]
id: UBERON:0012488
name: muscle layer of duodenum
def: "A muscular coat that is part of a duodenum." []
synonym: "duodenal muscularis propria" EXACT []
synonym: "muscularis externa of duodenum" EXACT []
synonym: "muscularis propria of duodenum" RELATED []
synonym: "smooth muscle of duodenum" RELATED []
is_a: UBERON:0011201 ! muscle layer of small intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0012489
name: muscle layer of colon
def: "A muscular coat that is part of a colon." []
synonym: "colon muscularis" RELATED []
synonym: "colonic muscularis propria" EXACT []
synonym: "muscular coat of colon" EXACT []
synonym: "muscular layer of colon" EXACT []
synonym: "muscularis externa of colon" EXACT []
synonym: "tunica muscularis coli" EXACT []
is_a: UBERON:0011198 ! muscle layer of large intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0012490
name: muscle layer of anal canal
def: "A muscular coat that is part of a anal canal." []
synonym: "anal canal muscularis propria" EXACT []
synonym: "anal muscularis propria" EXACT []
synonym: "muscular coat of anal canal" EXACT []
synonym: "muscular layer of anal canal" EXACT []
synonym: "muscularis externa of anal canal" EXACT []
synonym: "muscularis propria of anal canal" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011198 ! muscle layer of large intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0012498
name: serosa of appendix
def: "A serous membrane that is part of a vermiform appendix." []
synonym: "appendiceal serosa" EXACT []
synonym: "appendix serosa" EXACT []
synonym: "serosa of vermiform appendix" EXACT []
synonym: "visceral peritoneum of vermiform appendix" EXACT []
is_a: UBERON:0003335 ! serosa of colon
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: UBERON:0012499
name: serosa of uterine tube
def: "A serous membrane that is part of a fallopian tube." []
synonym: "serosa of fallopian tube" EXACT []
synonym: "serosa of oviduct" EXACT []
synonym: "serous coat of uterine tube" EXACT []
synonym: "tunica serosa (tuba uterina)" EXACT []
synonym: "tunica serosa tubae uterinae" EXACT []
synonym: "uterine tubal serosa" EXACT []
synonym: "uterine tube serosa" EXACT []
is_a: UBERON:0000042 ! serous membrane
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: part_of UBERON:0003889 ! fallopian tube

[Term]
id: UBERON:0012503
name: serosa of fundus of stomach
def: "A serous membrane that is part of a fundus of stomach." []
synonym: "visceral peritoneum of fundus of stomach" EXACT []
is_a: UBERON:0001201 ! serosa of stomach
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001160 ! fundus of stomach
relationship: part_of UBERON:0001201 ! serosa of stomach

[Term]
id: UBERON:0012504
name: adventitia of esophagus
def: "A adventitia that is part of a esophagus." []
synonym: "adventitia of oesophagus" EXACT []
synonym: "adventitious layer of esophagus" EXACT []
synonym: "esophageal adventitia" EXACT []
synonym: "esophagus adventitia" EXACT []
synonym: "tunica adventitia (esophagus)" EXACT []
synonym: "tunica adventitia oesophageae" EXACT []
is_a: UBERON:0005742 ! adventitia
intersection_of: UBERON:0005742 ! adventitia
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0012615
name: umbilical smooth muscle
def: "A smooth muscle tissue that is part of a umbilical cord." []
is_a: UBERON:0001135 ! smooth muscle tissue
is_a: UBERON:0005292 ! extraembryonic tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord

[Term]
id: UBERON:0013126
name: vein of abdomen
def: "A vein that is part of a abdomen." []
synonym: "abdominal vein" EXACT []
is_a: UBERON:0001638 ! vein
is_a: UBERON:0003497 ! abdomen blood vessel
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0013139
name: ligament of liver
def: "A nonskeletal ligament that is part of a liver." []
synonym: "hepatic ligament" EXACT []
synonym: "liver ligament" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005172 ! abdomen element
is_a: UBERON:0008845 ! nonskeletal ligament
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0008845 ! nonskeletal ligament
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0013140
name: systemic vein
def: "Any vein within the general circulation that transports blood back to the right atrium of the heart." []
synonym: "systemic venous tree organ part" EXACT []
is_a: UBERON:0001638 ! vein
intersection_of: UBERON:0001638 ! vein
intersection_of: part_of UBERON:0004581 ! systemic venous system
relationship: part_of UBERON:0004581 ! systemic venous system

[Term]
id: UBERON:0013149
name: hindbrain vesicle
synonym: "rhombencephalic vesicle" EXACT []
is_a: UBERON:0013150 ! future brain vesicle

[Term]
id: UBERON:0013150
name: future brain vesicle
synonym: "brain vesicle" RELATED []
synonym: "early brain vesicle" EXACT []
synonym: "primary brain vesicle" NARROW []
synonym: "primitive brain vesicle" EXACT []
synonym: "secondary brain vesicle" NARROW []
is_a: UBERON:0010064 ! open anatomical space
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0005281 ! ventricular system of central nervous system

[Term]
id: UBERON:0013158
name: foregut-midgut junction gland
def: "A gland that is part of a foregut-midgut junction." []
synonym: "gland of foregut-midgut junction" EXACT []
is_a: UBERON:0003408 ! gland of gut
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0006235 ! foregut-midgut junction
relationship: part_of UBERON:0006235 ! foregut-midgut junction

[Term]
id: UBERON:0013159
name: epithalamus mantle layer
synonym: "mantle layer epithalamus" EXACT []
synonym: "mantle layer of epithalamus" EXACT []
is_a: UBERON:0004061 ! neural tube mantle layer
intersection_of: UBERON:0004061 ! neural tube mantle layer
intersection_of: part_of UBERON:0001899 ! epithalamus
relationship: develops_from UBERON:0009580 ! diencephalon mantle layer
relationship: part_of UBERON:0001899 ! epithalamus

[Term]
id: UBERON:0013191
name: ovarian cortex
def: "the layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles." []
synonym: "cortex of ovary" EXACT []
synonym: "cortex ovarii (zona parenchymatosa)" EXACT []
is_a: UBERON:0001851 ! cortex
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0006960 ! ovary stroma

[Term]
id: UBERON:0013192
name: ovarian medulla
def: "highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles." []
synonym: "medulla of ovary" EXACT []
synonym: "medulla ovarii (zona vasculosa)" EXACT []
synonym: "zona vasculosa of Waldeyer" RELATED []
is_a: BFO:0000004 ! independent continuant
is_a: UBERON:0000958 ! medulla of organ
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000958 ! medulla of organ
intersection_of: part_of UBERON:0000992 ! female gonad
relationship: part_of UBERON:0000992 ! female gonad

[Term]
id: UBERON:0013229
name: eyelid gland
def: "Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland)." []
synonym: "gland of eyelid" EXACT []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004859 ! eye gland
is_a: UBERON:0015152 ! gland of ocular region
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0013231
name: sebaceous gland of eyelid
def: "Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids)." []
is_a: UBERON:0003484 ! eye sebaceous gland
is_a: UBERON:0013229 ! eyelid gland
intersection_of: UBERON:0001821 ! sebaceous gland
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0013232
name: serous acinus
def: "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." []
synonym: "acinus of serous gland" EXACT []
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0000409 ! serous gland
relationship: part_of UBERON:0000409 ! serous gland

[Term]
id: UBERON:0013241
name: embryonic urethral groove
def: "The precursor of the urethra" []
synonym: "sulcus urethralis primarius" EXACT []
synonym: "urethral groove" EXACT []
synonym: "urethral sulcus" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004876 ! urogenital fold

[Term]
id: UBERON:0013247
name: male paramesonephric duct
def: "A epithelial tube that develops from a Mullerian duct in a male. Later degenerates." []
synonym: "degenerating mesonephric portion of male paramesonephric duct" RELATED []
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0003914 ! epithelial tube
intersection_of: develops_from UBERON:0003890 ! Mullerian duct
intersection_of: part_of UBERON:0000079 ! male reproductive system
relationship: develops_from UBERON:0003890 ! Mullerian duct
relationship: part_of UBERON:0000079 ! male reproductive system

[Term]
id: UBERON:0013478
name: cecal tonsil
def: "A thickened round patch of lymphoid tissue located at the ileocecal junction adjacent to the sacculus rotundus." []
synonym: "caecal tonsil" EXACT []
synonym: "cecal GALT" RELATED []
is_a: UBERON:0001962 ! gut-associated lymphoid tissue
intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0000314 ! cecum mucosa
relationship: part_of UBERON:0001153 ! caecum

[Term]
id: UBERON:0013479
name: lung endothelium
def: "A blood vessel endothelium that is part of a lung [Automatically generated definition]." []
synonym: "respiratory endothelium" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0000115 ! lung epithelium
is_a: UBERON:0004702 ! respiratory system blood vessel endothelium
intersection_of: UBERON:0004638 ! blood vessel endothelium
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0013481
name: crypt of Lieberkuhn of ileum
def: "An intestinal crypt that is located in the ileum." []
synonym: "ileal crypt" EXACT []
synonym: "ileal crypt of Lieberkuhn" EXACT []
synonym: "ileal intestinal crypt" EXACT []
is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0008344 ! intestinal villus of ileum

[Term]
id: UBERON:0013482
name: crypt of Lieberkuhn of duodenum
def: "An intestinal crypt that is located in the duodenum." []
synonym: "duodenal crypt" EXACT []
synonym: "duodenal crypt of Lieberkuhn" EXACT []
is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008342 ! intestinal villus of duodenum

[Term]
id: UBERON:0013483
name: crypt of Lieberkuhn of jejunum
def: "An intestinal crypt that is located in the jejunum." []
synonym: "jejunal crypt" EXACT []
synonym: "jejunal crypt of Lieberkuhn" EXACT []
is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0008343 ! intestinal villus of jejunum

[Term]
id: UBERON:0013485
name: crypt of Lieberkuhn of colon
def: "An intestinal crypt that is located in the colon. The colonic crypts of Lieberkühn are straight and unbranched and lined largely with goblet cells." []
synonym: "colonic crypt" EXACT []
synonym: "colonic crypt of lieberkuhn" EXACT []
is_a: UBERON:0001984 ! crypt of Lieberkuhn of large intestine
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0000317 ! colonic mucosa
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0013486
name: crypt of Lieberkuhn of appendix
def: "An intestinal crypt that is located in the appendix." []
synonym: "appendiceal crypt" EXACT []
synonym: "appendiceal crypt of lieberkuhn" EXACT []
is_a: UBERON:0013485 ! crypt of Lieberkuhn of colon
intersection_of: UBERON:0001983 ! crypt of Lieberkuhn
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0004989 ! mucosa of appendix

[Term]
id: UBERON:0013501
name: cloacal sphincter
def: "A sphincter muscle that is part of a cloaca." []
synonym: "sphincter cloacae" EXACT []
is_a: UBERON:0004590 ! sphincter muscle
is_a: UBERON:0014783 ! cloacal muscle
intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0013515
name: subdivision of oviduct
def: "A section through the tube or network of tubes that connects the ovaries to the outside of the body." []
synonym: "subdivision of fallopian tube" NARROW []
synonym: "subdivision of oviduct" EXACT []
synonym: "subdivision of uterine tube" EXACT []
synonym: "uterine tube zone" EXACT []
synonym: "zone of uterine tube" EXACT []
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0013522 ! subdivision of tube
relationship: part_of UBERON:0000993 ! oviduct

[Term]
id: UBERON:0013522
name: subdivision of tube
is_a: UBERON:0000064 ! organ part
relationship: has_part UBERON:0000060 ! anatomical wall
relationship: has_part UBERON:0000464 ! anatomical space
relationship: part_of UBERON:0000025 ! tube

[Term]
id: UBERON:0013636
name: epithelium of intestinal villus
def: "A epithelium that is part of a intestinal villus." []
synonym: "intestinal villus epithelium" EXACT []
synonym: "villous epithelium" RELATED []
synonym: "villus epithelium" RELATED []
is_a: UBERON:0001902 ! epithelium of small intestine
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0001213 ! intestinal villus
relationship: part_of UBERON:0001902 ! epithelium of small intestine

[Term]
id: UBERON:0013685
name: foramen of skull
def: "Anatomical space that is an opening in a bone of the skull." []
synonym: "cranial conduit" NARROW []
synonym: "cranial foramen" NARROW []
synonym: "foramen of skull" EXACT []
synonym: "foramina of the skull" RELATED []
is_a: UBERON:0005744 ! bone foramen
intersection_of: UBERON:0005744 ! bone foramen
intersection_of: part_of UBERON:0003129 ! skull
relationship: part_of UBERON:0003129 ! skull

[Term]
id: UBERON:0013686
name: anatomical conduit space
def: "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." []
synonym: "foramen space" NARROW []
is_a: UBERON:0000464 ! anatomical space

[Term]
id: UBERON:0013687
name: pericranium
def: "Periosteum that is part of a skull." []
synonym: "periosteum externum cranii" EXACT []
is_a: UBERON:0002515 ! periosteum
intersection_of: UBERON:0002515 ! periosteum
intersection_of: part_of UBERON:0003129 ! skull
relationship: part_of UBERON:0003129 ! skull

[Term]
id: UBERON:0013688
name: tonsil germinal center
def: "A germinal center that is part of a tonsil." []
synonym: "tonsil reaction center" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0010754 ! germinal center
intersection_of: UBERON:0010754 ! germinal center
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: UBERON:0013689
name: appendix lymphoid tissue
def: "Lymphoid tissue located in the appendix." []
synonym: "appendix lymphoid" RELATED []
synonym: "lymphatic tissue of appendix" EXACT []
synonym: "lymphatic tissue of vermiform appendix" EXACT []
is_a: UBERON:0001744 ! lymphoid tissue
intersection_of: UBERON:0001744 ! lymphoid tissue
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix

[Term]
id: UBERON:0013694
name: brain endothelium
def: "Vascular endothelium found in blood vessels of the blood-brain-barrier." []
synonym: "cerebromicrovascular endothelium" RELATED []
is_a: UBERON:0001986 ! endothelium
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain

[Term]
id: UBERON:0013695
name: colon endothelium
def: "Vascular endothelium found in colon blood vessels." []
synonym: "colon endothelial cell" RELATED []
synonym: "colon endothelial cells" RELATED []
synonym: "colonic endothelial cell" RELATED []
synonym: "colonic endothelium" RELATED []
synonym: "colorectal endothelial cell" RELATED []
synonym: "colorectal endothelium" RELATED []
is_a: UBERON:0000397 ! colonic epithelium
is_a: UBERON:0001986 ! endothelium
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: UBERON:0013696
name: tonsil epithelium
def: "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." []
synonym: "epithelium of tonsil" RELATED []
synonym: "tonsil epithelial cell" RELATED []
is_a: UBERON:0003351 ! pharyngeal epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil

[Term]
id: UBERON:0013697
name: exocrine pancreas epithelium
def: "Epithelium lining the exocrine pancreas." []
synonym: "epithelium of exocrine pancreas" RELATED []
synonym: "exocrine pancreas epithelial cell" RELATED []
is_a: UBERON:0005911 ! endo-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas

[Term]
id: UBERON:0013700
name: axial musculature
def: "Musculature of the head and neck, spine, and ribs." []
is_a: UBERON:0001015 ! musculature
relationship: part_of UBERON:0013701 ! main body axis

[Term]
id: UBERON:0013701
name: main body axis
def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." []
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0013702
name: body proper
def: "The region of the organism associated with the visceral organs." []
synonym: "body" RELATED []
synonym: "whole body" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0013701 ! main body axis

[Term]
id: UBERON:0013703
name: integumentary projection
def: "Anatomical projection that is part of the integumentl system." []
synonym: "skin projection" NARROW []
is_a: UBERON:0004529 ! anatomical projection
is_a: UBERON:0006003 ! integumentary adnexa
intersection_of: UBERON:0004529 ! anatomical projection
intersection_of: part_of UBERON:0002416 ! integumental system
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0013704
name: notochordal canal
def: "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." []
synonym: "chordal canal" RELATED []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0004111 ! anatomical conduit
intersection_of: part_of UBERON:0006268 ! notochordal process
relationship: part_of UBERON:0006268 ! notochordal process

[Term]
id: UBERON:0013754
name: integumentary system layer
def: "A organ component layer that is part of a integumental system." []
synonym: "layer of skin" NARROW []
synonym: "skin layer" NARROW []
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: part_of UBERON:0002416 ! integumental system
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0013755
name: arterial blood
def: "A blood that is part of a artery." []
synonym: "arterial blood" EXACT []
synonym: "blood in artery" EXACT []
synonym: "portion of arterial blood" EXACT []
is_a: UBERON:0000178 ! blood
intersection_of: UBERON:0000178 ! blood
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0013756
name: venous blood
def: "A blood that is part of a vein." []
synonym: "blood in vein" EXACT []
synonym: "portion of venous blood" EXACT []
synonym: "venous blood" EXACT []
is_a: UBERON:0000178 ! blood
intersection_of: UBERON:0000178 ! blood
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein

[Term]
id: UBERON:0013757
name: capillary blood
def: "A blood that is part of a capillary." []
synonym: "blood in capillary" EXACT []
synonym: "portion of blood in capillary" EXACT []
synonym: "portion of capillary blood" EXACT []
is_a: UBERON:0000178 ! blood
intersection_of: UBERON:0000178 ! blood
intersection_of: part_of UBERON:0001982 ! capillary
relationship: part_of UBERON:0001982 ! capillary

[Term]
id: UBERON:0013758
name: cervical os
def: "One of two openings in the uterine cervix." []
synonym: "cervical opening" RELATED []
synonym: "uterine cervix opening" RELATED []
is_a: UBERON:0000161 ! orifice
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix

[Term]
id: UBERON:0013765
name: digestive system element
def: "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." []
synonym: "digestive organ" EXACT []
synonym: "digestive system organ" EXACT []
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: part_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0001007 ! digestive system

[Term]
id: UBERON:0013768
name: great vessel of heart
def: "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." []
synonym: "great vessel" BROAD []
synonym: "great vessel of thorax" EXACT []
is_a: UBERON:0001981 ! blood vessel

[Term]
id: UBERON:0013769
name: uterine lumen
def: "A organ cavity that is part of a uterus." []
synonym: "cavity of uterus" EXACT []
synonym: "uterine cavity" EXACT []
synonym: "uterine space" EXACT []
is_a: UBERON:0002558 ! organ cavity
intersection_of: UBERON:0002558 ! organ cavity
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0014387
name: mesenchyme derived from neural crest
def: "Mesenchyme that develops_from the neural crest[Automatically generated definition]." []
synonym: "mesenchyme from neural crest" EXACT []
synonym: "neural crest derived mesenchyme" EXACT []
synonym: "neural crest mesenchyme" EXACT []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0002342 ! neural crest
relationship: develops_from UBERON:0002342 ! neural crest

[Term]
id: UBERON:0014388
name: kidney collecting duct epithelium
def: "The simple cuboidal epithelium lining the lumen of kidney collecting ducts." []
synonym: "collecting duct of renal tubule epithelium" EXACT []
synonym: "epithelium of collecting duct of renal tubule" EXACT []
synonym: "epithelium of renal collecting tubule" EXACT []
is_a: UBERON:0000484 ! simple cuboidal epithelium
is_a: UBERON:0004211 ! nephron epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: UBERON:0014390
name: muscle layer of ileum
def: "A muscular coat that is part of a ileum." []
synonym: "ileal smooth muscle" RELATED []
synonym: "muscularis externa of ileum" EXACT []
synonym: "muscularis propria of ileum" RELATED []
synonym: "smooth muscle of ileum" RELATED []
is_a: UBERON:0011201 ! muscle layer of small intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: UBERON:0014401
name: renal venous blood vessel
def: "Any member of the network of tubes that return blood from the renal tissues to the systemic circulation." []
synonym: "kidney venous blood vessel" EXACT []
synonym: "kidney venous system" RELATED []
synonym: "venous blood vessel of kidney" EXACT []
is_a: UBERON:0003517 ! kidney blood vessel
is_a: UBERON:0003920 ! venous blood vessel
intersection_of: UBERON:0003920 ! venous blood vessel
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: UBERON:0014452
name: gustatory epithelium of tongue
def: "A gustatory epithelium that is part of a tongue." []
synonym: "lingual gustatory epithelium" EXACT []
is_a: UBERON:0002926 ! gustatory epithelium
is_a: UBERON:0003357 ! epithelium of tongue
intersection_of: UBERON:0002926 ! gustatory epithelium
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0014455
name: subcutaneous abdominal adipose tissue
def: "Subcutaneous adipose tissue that is located in the abdominal region." []
synonym: "abdominal subcutaneous adipose tissue" EXACT []
synonym: "subcutaneous abdominal fat" EXACT []
synonym: "subcutaneous fat of abdominal region" EXACT []
is_a: UBERON:0002190 ! subcutaneous adipose tissue
is_a: UBERON:0007808 ! adipose tissue of abdominal region
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0000916 ! abdomen
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0014530
name: white matter lamina of neuraxis
synonym: "lamina of neuraxis" BROAD []
synonym: "neuraxis lamina" BROAD []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0022303 ! nervous system cell part layer
intersection_of: UBERON:0022303 ! nervous system cell part layer
intersection_of: part_of UBERON:0002316 ! white matter
relationship: part_of UBERON:0002316 ! white matter

[Term]
id: UBERON:0014531
name: white matter lamina of diencephalon
synonym: "diencephalon lamina" BROAD []
synonym: "lamina of diencephalon" BROAD []
is_a: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0014532
name: white matter lamina of cerebral hemisphere
synonym: "cerebral hemisphere lamina" BROAD []
synonym: "lamina of cerebral hemisphere" BROAD []
is_a: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: part_of UBERON:0001869 ! cerebral hemisphere
relationship: part_of UBERON:0001869 ! cerebral hemisphere

[Term]
id: UBERON:0014540
name: white matter lamina of cerebellum
def: "The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex." []
synonym: "isthmus cinguli" RELATED []
synonym: "isthmus gyri cingulatus" RELATED []
synonym: "isthmus gyri cinguli" RELATED []
synonym: "isthmus of Gyrus fornicatus" RELATED []
synonym: "isthmus of the cingulate gyrus" RELATED []
synonym: "isthmus-2" RELATED []
synonym: "lamina alba of cerebellar cortex" EXACT []
synonym: "laminae albae of cerebellar cortex" EXACT []
synonym: "laminae albae of cerebellar cortex" RELATED []
synonym: "white lamina of cerebellum" EXACT []
synonym: "white laminae of cerebellum" EXACT []
is_a: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: UBERON:0014530 ! white matter lamina of neuraxis
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum

[Term]
id: UBERON:0014649
name: white matter of medulla oblongata
def: "A white matter that is part of a medulla oblongata." []
synonym: "medullary white matter" RELATED []
synonym: "substantia alba medullae oblongatae" EXACT []
synonym: "white matter of medulla" EXACT []
synonym: "white substance of medulla" EXACT []
is_a: UBERON:0014891 ! brainstem white matter
is_a: UBERON:0019262 ! white matter of myelencephalon
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001896 ! medulla oblongata
relationship: part_of UBERON:0001896 ! medulla oblongata

[Term]
id: UBERON:0014699
name: extraembryonic venous system
def: "A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component." []
is_a: UBERON:0004582 ! venous system
is_a: UBERON:0014701 ! extraembryonic vascular system
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0014701
name: extraembryonic vascular system
def: "A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component." []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0007798 ! vascular system
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0014702
name: frontonasal process epithelium
def: "A epithelium that is part of a frontonasal prominence." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004066 ! frontonasal prominence
relationship: develops_from UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0004066 ! frontonasal prominence

[Term]
id: UBERON:0014703
name: anal membrane ectodermal component
def: "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: part_of UBERON:0001353 ! anal region
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0001353 ! anal region

[Term]
id: UBERON:0014706
name: primitive renal collecting duct system
synonym: "metanephros primitive collecting ducts" EXACT []
synonym: "primitive collecting duct" EXACT []
is_a: UBERON:0007501 ! arborizing epithelial duct system
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0000084 ! ureteric bud

[Term]
id: UBERON:0014716
name: interlobular duct
def: "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." []
is_a: UBERON:0035050 ! excretory duct
relationship: part_of UBERON:0002384 ! connective tissue

[Term]
id: UBERON:0014717
name: mucous acinus
def: "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." []
synonym: "acinus of mucuous gland" EXACT []
synonym: "mucus acinus" EXACT []
is_a: UBERON:0011858 ! acinus of exocrine gland
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0000414 ! mucous gland
relationship: part_of UBERON:0000414 ! mucous gland

[Term]
id: UBERON:0014719
name: intralobular duct
def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular" []
synonym: "intralobular ductule" RELATED []
is_a: UBERON:0000058 ! duct
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0009911 ! lobule
relationship: part_of UBERON:0009911 ! lobule

[Term]
id: UBERON:0014775
name: prosomere
def: "A neuromere that is part of the presumptive forebrain" []
synonym: "forebrain neuromere" EXACT []
synonym: "forebrain segment" BROAD []
synonym: "future prosencephalon" RELATED []
synonym: "segment of forebrain" BROAD []
is_a: UBERON:0004731 ! neuromere
intersection_of: UBERON:0004731 ! neuromere
intersection_of: part_of UBERON:0006240 ! future forebrain
relationship: part_of UBERON:0006240 ! future forebrain

[Term]
id: UBERON:0014776
name: midbrain neuromere
def: "A neuromere that is part of the presumptive midbrain" []
synonym: "future mesencephalon" RELATED []
synonym: "mesomere" BROAD []
synonym: "mesomere group" RELATED []
synonym: "mesomere of nervous system" EXACT []
synonym: "midbrain segment" BROAD []
synonym: "neuromere of mesomere group" EXACT []
synonym: "segment of midbrain" BROAD []
is_a: UBERON:0004731 ! neuromere
intersection_of: UBERON:0004731 ! neuromere
intersection_of: part_of UBERON:0009616 ! presumptive midbrain
relationship: part_of UBERON:0009616 ! presumptive midbrain

[Term]
id: UBERON:0014783
name: cloacal muscle
def: "Any muscle organ that is part of a cloaca." []
is_a: UBERON:0001630 ! muscle organ
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0013765 ! digestive system element
intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0000162 ! cloaca
relationship: part_of UBERON:0000162 ! cloaca

[Term]
id: UBERON:0014790
name: lingual septum
def: "The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ." []
synonym: "median fibrous septum" RELATED []
synonym: "septum of tongue" EXACT []
synonym: "septum of tongue" RELATED []
synonym: "tongue septum" RELATED []
is_a: UBERON:0003037 ! septum
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0003037 ! septum
intersection_of: part_of UBERON:0001723 ! tongue
relationship: part_of UBERON:0001723 ! tongue

[Term]
id: UBERON:0014791
name: musculature of forelimb stylopod
def: "Any collection of muscles that is part of an arm [Automatically generated definition]." []
synonym: "arm musculature" RELATED []
synonym: "muscle group of arm" RELATED []
synonym: "musculature of arm" RELATED []
synonym: "set of muscles of arm" RELATED []
is_a: UBERON:0004474 ! musculature of arm
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
relationship: part_of UBERON:0003822 ! forelimb stylopod

[Term]
id: UBERON:0014792
name: musculature of pelvic complex
def: "Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin." []
synonym: "muscles of lower limb" NARROW []
synonym: "musculature of lower limb" NARROW []
synonym: "musculi membri inferioris" NARROW []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0010709 ! pelvic complex
relationship: part_of UBERON:0010709 ! pelvic complex

[Term]
id: UBERON:0014793
name: musculature of pectoral complex
def: "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." []
synonym: "muscles of upper limb" NARROW []
synonym: "musculature of upper limb" NARROW []
synonym: "musculi membri superioris" NARROW []
synonym: "set of muscles of upper limb" NARROW []
synonym: "upper limb musculature" NARROW []
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: part_of UBERON:0010708 ! pectoral complex
relationship: part_of UBERON:0010708 ! pectoral complex

[Term]
id: UBERON:0014794
name: pectoral appendage muscle
def: "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." []
is_a: UBERON:0010891 ! pectoral complex muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0004710 ! pectoral appendage
relationship: part_of UBERON:0007269 ! pectoral appendage musculature

[Term]
id: UBERON:0014795
name: pelvic appendage muscle
def: "Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin)." []
is_a: UBERON:0010890 ! pelvic complex muscle
intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0004709 ! pelvic appendage
relationship: part_of UBERON:0007270 ! pelvic appendage musculature

[Term]
id: UBERON:0014891
name: brainstem white matter
def: "White matter that is part of a brainstem [Automatically generated definition]." []
synonym: "brain stem white matter" RELATED []
synonym: "brainstem tract/commissure" RELATED []
synonym: "brainstem tracts" RELATED []
synonym: "brainstem tracts and commissures" RELATED []
is_a: UBERON:0003544 ! brain white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0002298 ! brainstem

[Term]
id: UBERON:0014892
name: skeletal muscle organ
def: "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." []
synonym: "skeletal muscle" BROAD []
is_a: UBERON:0001630 ! muscle organ
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0003082 ! myotome
relationship: part_of UBERON:0018254 ! skeletal musculature

[Term]
id: UBERON:0014903
name: primordial vasculature
def: "A portion of tissue that will develop into vasculature." []
is_a: UBERON:0001048 ! primordium
relationship: part_of UBERON:0011695 ! embryonic cardiovascular system

[Term]
id: UBERON:0014907
name: intersomitic vessel
def: "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." []
synonym: "intersegmental vessel" EXACT []
synonym: "intersegmental vessels" EXACT []
synonym: "intersomitic blood vessel" EXACT []
synonym: "intersomitic vessels" EXACT []
synonym: "segmental vessel" EXACT []
is_a: UBERON:0001981 ! blood vessel
relationship: develops_from UBERON:0005805 ! dorsal aorta

[Term]
id: UBERON:0015021
name: forelimb endochondral element
def: "A forelimb bone or its cartilage or pre-cartilage precursor." []
synonym: "forelimb skeletal element" BROAD []
is_a: UBERON:0015061 ! limb endochondral element
intersection_of: UBERON:0010363 ! endochondral element
intersection_of: part_of UBERON:0002102 ! forelimb
union_of: UBERON:0008962 ! forelimb bone
union_of: UBERON:0010883 ! forelimb cartilage element
union_of: UBERON:0010884 ! forelimb bone pre-cartilage condensation
relationship: part_of UBERON:0001440 ! forelimb skeleton
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0015022
name: hindlimb endochondral element
def: "A hindlimb bone or its cartilage or pre-cartilage precursor." []
synonym: "hindlimb bone skeletal element" BROAD []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004765 ! skeletal element
intersection_of: UBERON:0004765 ! skeletal element
intersection_of: part_of UBERON:0002103 ! hindlimb
union_of: UBERON:0003464 ! hindlimb bone
union_of: UBERON:0010885 ! hindlimb cartilage element
union_of: UBERON:0010886 ! hindlimb pre-cartilage condensation
relationship: part_of UBERON:0001441 ! hindlimb skeleton
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0015023
name: phalanx endochondral element
def: "A phalanx bone or its cartilage or pre-cartilage precursor." []
synonym: "phalanx element" EXACT []
synonym: "phalanx skeletal element" BROAD []
is_a: UBERON:0015063 ! autopod endochondral element
union_of: UBERON:0003221 ! phalanx
union_of: UBERON:0010700 ! phalanx pre-cartilage condensation
union_of: UBERON:0010701 ! phalanx cartilage element
relationship: part_of UBERON:0002544 ! digit
relationship: part_of UBERON:0012150 ! skeleton of digitopodium

[Term]
id: UBERON:0015024
name: manual digit phalanx endochondral element
def: "A manual digit phalanx bone or its cartilage or pre-cartilage precursor." []
synonym: "manual digit phalanx element" EXACT []
synonym: "manual digit phalanx skeletal element" BROAD []
is_a: UBERON:0015021 ! forelimb endochondral element
is_a: UBERON:0015023 ! phalanx endochondral element
intersection_of: UBERON:0015023 ! phalanx endochondral element
intersection_of: part_of UBERON:0002389 ! manual digit
union_of: UBERON:0001436 ! phalanx of manus
union_of: UBERON:0010586 ! manual digit phalanx pre-cartilage condensation
union_of: UBERON:0010686 ! manual digit phalanx cartilage element
relationship: part_of UBERON:0002389 ! manual digit
relationship: part_of UBERON:0010688 ! skeleton of manual acropodium
relationship: part_of UBERON:5102389 ! manual digit digitopodial skeleton

[Term]
id: UBERON:0015030
name: pedal digit phalanx endochondral element
def: "A pedal digit phalanx bone or its cartilage or pre-cartilage precursor." []
synonym: "pedal digit phalanx element" EXACT []
synonym: "pedal digit phalanx skeletal element" BROAD []
is_a: UBERON:0015022 ! hindlimb endochondral element
is_a: UBERON:0015023 ! phalanx endochondral element
intersection_of: UBERON:0015023 ! phalanx endochondral element
intersection_of: part_of UBERON:0001466 ! pedal digit
union_of: UBERON:0001449 ! phalanx of pes
union_of: UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation
union_of: UBERON:0010685 ! pedal digit phalanx cartilage element
relationship: part_of UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0010696 ! skeleton of pedal acropodium
relationship: part_of UBERON:5101466 ! pedal digit digitopodial skeleton

[Term]
id: UBERON:0015052
name: femur endochondral element
def: "A femur bone or its cartilage or pre-cartilage precursor." []
synonym: "femur element" EXACT []
synonym: "femur skeletal element" BROAD []
is_a: UBERON:0015022 ! hindlimb endochondral element
is_a: UBERON:0015061 ! limb endochondral element
union_of: UBERON:0000981 ! femur
union_of: UBERON:0006234 ! femur pre-cartilage condensation
union_of: UBERON:0010129 ! femur cartilage element
relationship: part_of UBERON:0000376 ! hindlimb stylopod
relationship: part_of UBERON:0001441 ! hindlimb skeleton

[Term]
id: UBERON:0015061
name: limb endochondral element
def: "A limb bone or its cartilage or pre-cartilage precursor." []
synonym: "limb bone endochondral element" EXACT []
synonym: "limb bone skeletal element" BROAD []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010363 ! endochondral element
intersection_of: UBERON:0010363 ! endochondral element
intersection_of: part_of UBERON:0002101 ! limb
union_of: UBERON:0002428 ! limb bone
union_of: UBERON:0010881 ! limb cartilage element
union_of: UBERON:0010882 ! limb bone pre-cartilage condensation
relationship: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0004381 ! skeleton of limb

[Term]
id: UBERON:0015063
name: autopod endochondral element
def: "A endochondral element that is part of a autopod region." []
is_a: UBERON:0015061 ! limb endochondral element
intersection_of: UBERON:0010363 ! endochondral element
intersection_of: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0006717 ! autopodial skeleton

[Term]
id: UBERON:0015064
name: autopod cartilage
def: "A autopod endochondral element that is composed primarily of a cartilage tissue." []
is_a: UBERON:0010881 ! limb cartilage element
is_a: UBERON:0015063 ! autopod endochondral element

[Term]
id: UBERON:0015130
name: connective tissue of prostate gland
def: "A portion of connective tissue that is part of a prostate gland." []
synonym: "connective tissue of prostate" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0011822 ! dense irregular connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0015144
name: autopod hair
def: "A strand of hair that is part of a autopod region." []
synonym: "hair of hand/foot" EXACT []
synonym: "hand/foot hair" EXACT []
synonym: "paw hair" NARROW []
is_a: UBERON:0001037 ! strand of hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0002470 ! autopod region

[Term]
id: UBERON:0015145
name: pes hair
def: "A strand of hair that is part of a pes." []
synonym: "foot hair" EXACT []
synonym: "hair of foot" EXACT []
synonym: "hind foot hair" EXACT []
synonym: "hind paw hair" NARROW []
is_a: UBERON:0015144 ! autopod hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0015146
name: manus hair
def: "A strand of hair that is part of a manus." []
synonym: "front paw hair" NARROW []
synonym: "hair of hand" EXACT []
synonym: "hand hair" EXACT []
is_a: UBERON:0015144 ! autopod hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0002398 ! manus
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0015147
name: pinna hair
def: "A strand of hair that is part of a pinna." []
synonym: "ear hair" RELATED []
is_a: UBERON:0022279 ! strand of hair on external ear
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0001757 ! pinna
relationship: part_of UBERON:0001757 ! pinna

[Term]
id: UBERON:0015150
name: dorsal hair
def: "A strand of hair that is part of a dorsum." []
synonym: "back hair" RELATED []
synonym: "dorsal coat hair" RELATED []
synonym: "hair of back" RELATED []
is_a: UBERON:0001037 ! strand of hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0001137 ! dorsum

[Term]
id: UBERON:0015152
name: gland of ocular region
def: "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." []
synonym: "ocular gland" EXACT []
synonym: "orbital gland" RELATED []
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0004088 ! orbital region
relationship: part_of UBERON:0004088 ! orbital region
relationship: part_of UBERON:0035639 ! ocular adnexa

[Term]
id: UBERON:0015154
name: lateral gland of orbital region
def: "A gland that is located in or around the ocular region, nearer the outer canthi." []
synonym: "lateral ocular gland" EXACT []
synonym: "lateral orbital gland" EXACT []
is_a: UBERON:0015152 ! gland of ocular region

[Term]
id: UBERON:0015165
name: multi-unit eye
def: "An eye consisting of multiple light-sensing organs" []
is_a: UBERON:0000970 ! eye

[Term]
id: UBERON:0015172
name: endometrial blood vessel
def: "A blood vessel that is part of a endometrium." []
synonym: "blood vessel of endometrium" EXACT []
is_a: UBERON:0001981 ! blood vessel
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium

[Term]
id: UBERON:0015181
name: neck of tooth
def: "The slightly constricted part of a tooth, between the crown and the root." []
synonym: "cervical margin of tooth" RELATED []
synonym: "cervical zone of tooth" RELATED []
synonym: "cervix dentis" EXACT []
synonym: "cervix of tooth" EXACT []
synonym: "collumn dentis" EXACT []
synonym: "dental neck" EXACT []
synonym: "tooth neck" EXACT []
is_a: UBERON:0001560 ! neck of organ
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0001091 ! calcareous tooth
relationship: part_of UBERON:0001091 ! calcareous tooth

[Term]
id: UBERON:0015212
name: lateral structure
def: "Any structure that is placed on one side of the left-right axis of a bilaterian." []
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0015228
name: circulatory organ
def: "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." []
synonym: "cardiac pump" EXACT []
synonym: "cardiac structure" RELATED []
synonym: "circulatory vessel" NARROW []
synonym: "heart" BROAD []
synonym: "heart or heart like organ" EXACT []
is_a: UBERON:0003103 ! compound organ
relationship: part_of UBERON:0001009 ! circulatory system

[Term]
id: UBERON:0015238
name: pineal complex
def: "A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals." []
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0001899 ! epithalamus

[Term]
id: UBERON:0015249
name: digit skin
def: "A zone of skin that is part of a digit [Automatically generated definition]." []
is_a: UBERON:0015790 ! autopod skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002544 ! digit
relationship: part_of UBERON:0002544 ! digit

[Term]
id: UBERON:0015329
name: respiratory system basement membrane
def: "A basement membrane of epithelium that is part of a respiratory system." []
is_a: UBERON:0005769 ! basement membrane of epithelium
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003570 ! respiratory system connective tissue

[Term]
id: UBERON:0015410
name: heart plus pericardium
synonym: "heart/pericardium" EXACT []
is_a: UBERON:0005178 ! thoracic cavity element
relationship: part_of UBERON:0004535 ! cardiovascular system

[Term]
id: UBERON:0015418
name: urethra mesenchymal layer
def: "A mesenchyme that is part of a urethra." []
is_a: UBERON:0003104 ! mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: UBERON:0015453
name: subcutaneous lymph node
def: "A lymph node that is part of a hypodermis." []
is_a: UBERON:0000029 ! lymph node
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0015716
name: anal canal epithelium
def: "A epithelium that is part of a anal canal." []
synonym: "anal canal epithelium" EXACT []
synonym: "epithelium of anal canal" EXACT []
is_a: UBERON:0001278 ! epithelium of large intestine
is_a: UBERON:0014703 ! anal membrane ectodermal component
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: part_of UBERON:0000159 ! anal canal

[Term]
id: UBERON:0015757
name: heterogeneous tissue
synonym: "portion of heterogeneous tissue" EXACT []
is_a: UBERON:0000479 ! tissue

[Term]
id: UBERON:0015766
name: epithelium of duct of salivary gland
def: "A epithelium that is part of a duct of salivary gland." []
synonym: "epithelium of salivary duct" EXACT []
synonym: "salivary duct epithelium" EXACT []
synonym: "salivary ductal epithelium" EXACT []
is_a: UBERON:0004809 ! salivary gland epithelium
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001837 ! duct of salivary gland
relationship: part_of UBERON:0001837 ! duct of salivary gland

[Term]
id: UBERON:0015783
name: smooth muscle layer in fatty layer of subcutaneous tissue
def: "A smooth muscle tissue that is part of a hypodermis." []
synonym: "muscle layer in fatty layer of subcutaneous tissue" EXACT []
synonym: "stratum musculosum panniculi adiposi telae subcutaneae" EXACT []
is_a: UBERON:0001135 ! smooth muscle tissue
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: part_of UBERON:0002072 ! hypodermis

[Term]
id: UBERON:0015786
name: respiratory segment of nasal mucosa
def: "The portion of the nasal mucosa that is part of the respiratory system." []
synonym: "pars respiratoria tunicae mucosae nasi" EXACT []
synonym: "respiratory zone of nasal mucosa" EXACT []
is_a: UBERON:0001826 ! nasal cavity mucosa
intersection_of: UBERON:0001826 ! nasal cavity mucosa
intersection_of: has_part UBERON:0005385 ! nasal cavity respiratory epithelium
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: has_part UBERON:0005385 ! nasal cavity respiratory epithelium
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0015787
name: upper respiratory conduit
def: "Any anatomical conduit which is part of the upper respiratory tract" []
synonym: "respiratory conduit" RELATED []
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0004111 ! anatomical conduit
intersection_of: part_of UBERON:0001557 ! upper respiratory tract
relationship: part_of UBERON:0001557 ! upper respiratory tract

[Term]
id: UBERON:0015788
name: olfactory apparatus chamber
def: "An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." []
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0015787 ! upper respiratory conduit
relationship: part_of UBERON:0000004 ! nose

[Term]
id: UBERON:0015789
name: cranial or facial muscle
synonym: "cranial-facial muscle" RELATED []
synonym: "cranial/facial muscle" EXACT []
synonym: "cranio-facial muscle" RELATED []
synonym: "craniofacial muscle" RELATED []
is_a: UBERON:0002376 ! cranial muscle
relationship: part_of UBERON:0004473 ! musculature of face

[Term]
id: UBERON:0015790
name: autopod skin
def: "A zone of skin that is part of a autopod region." []
synonym: "paw skin" RELATED []
is_a: UBERON:0001419 ! skin of limb
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002470 ! autopod region
relationship: part_of UBERON:0002470 ! autopod region

[Term]
id: UBERON:0015791
name: digit connective tissue
def: "A portion of connective tissue that is part of a digit." []
is_a: UBERON:0003587 ! limb connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002544 ! digit
relationship: part_of UBERON:0002544 ! digit

[Term]
id: UBERON:0015796
name: liver blood vessel
def: "A blood vessel that is part of a liver." []
synonym: "hepatic blood vessel" RELATED []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003497 ! abdomen blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0015807
name: ear epithelium
def: "A epithelium that is part of a ear." []
is_a: UBERON:0019304 ! sensory organ epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001690 ! ear
relationship: part_of UBERON:0001690 ! ear

[Term]
id: UBERON:0015808
name: eye epithelium
def: "A epithelium that is part of a camera-type eye." []
is_a: UBERON:0007625 ! pigment epithelium of eye
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: UBERON:0015813
name: middle ear epithelium
def: "A epithelium that is part of a middle ear." []
is_a: UBERON:0015807 ! ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001756 ! middle ear
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0015814
name: outer ear epithelium
def: "A epithelium that is part of a external ear." []
is_a: UBERON:0015807 ! ear epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001691 ! external ear
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0015833
name: foregut epithelium
def: "A epithelium that is part of a foregut." []
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001041 ! foregut
relationship: part_of UBERON:0001041 ! foregut

[Term]
id: UBERON:0015834
name: duodenum lamina propria
def: "A lamina propria that is part of a duodenum." []
synonym: "duodenal lamina propria" EXACT []
synonym: "lamina propria mucosae of duodenum" EXACT []
synonym: "lamina propria of duodenum" EXACT []
is_a: UBERON:0001238 ! lamina propria of small intestine
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0000320 ! duodenal mucosa
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008342 ! intestinal villus of duodenum

[Term]
id: UBERON:0015860
name: visceral abdominal lymph node
is_a: UBERON:0002507 ! abdominal lymph node

[Term]
id: UBERON:0015870
name: lymph node of head
def: "A lymph node that is part of a head." []
is_a: UBERON:0000029 ! lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0015871
name: facial lymph node
def: "A lymph node that is part of a face." []
synonym: "buccal lymph node" EXACT []
is_a: UBERON:0015870 ! lymph node of head
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:0016398
name: lymph node of lower limb
def: "A lymph node that is part of a hindlimb." []
is_a: UBERON:0000029 ! lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: part_of UBERON:0002103 ! hindlimb

[Term]
id: UBERON:0016399
name: lymph node of upper limb
def: "A lymph node that is part of a forelimb." []
is_a: UBERON:0000029 ! lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:0016405
name: pulmonary capillary
def: "A capillary that is part of a lung." []
synonym: "capillary of lung" EXACT []
is_a: UBERON:0003512 ! lung blood vessel
is_a: UBERON:0003526 ! respiratory system capillary
intersection_of: UBERON:0001982 ! capillary
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0016410
name: male breast
def: "A breast that is part of a male organism." []
synonym: "mamma masculina" EXACT []
is_a: UBERON:0000310 ! breast
intersection_of: UBERON:0000310 ! breast
intersection_of: part_of UBERON:0003101 ! male organism
relationship: part_of UBERON:0003101 ! male organism

[Term]
id: UBERON:0016435
name: chest wall
def: "Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall." []
is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001443 ! chest
relationship: part_of UBERON:0001443 ! chest

[Term]
id: UBERON:0016446
name: hair of head
def: "A strand of hair that is part of a head." []
synonym: "hair of scalp" EXACT []
synonym: "head hair" EXACT []
is_a: UBERON:0001037 ! strand of hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0016447
name: hair of trunk
def: "A strand of hair that is part of a trunk." []
synonym: "trunk hair" EXACT []
is_a: UBERON:0001037 ! strand of hair
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0016478
name: liver stroma
def: "A stroma that is part of a liver." []
synonym: "hepatic stroma" EXACT []
synonym: "stroma of liver" EXACT []
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver

[Term]
id: UBERON:0016481
name: bronchial lymph node
def: "A lymph node that is part of a bronchus." []
is_a: UBERON:0000029 ! lymph node
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus

[Term]
id: UBERON:0016490
name: auditory system
def: "is the sensory system for the sense of hearing." []
is_a: UBERON:0007037 ! mechanosensory system
relationship: part_of UBERON:0002105 ! vestibulo-auditory system

[Term]
id: UBERON:0016510
name: epithelium of male urethra
def: "A epithelium that is part of a male urethra." []
synonym: "male urethral epithelium" EXACT []
synonym: "urethral epithelium of male" EXACT []
is_a: UBERON:0002325 ! epithelium of urethra
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001333 ! male urethra
relationship: part_of UBERON:0001333 ! male urethra

[Term]
id: UBERON:0016511
name: lamina propria of fundus of stomach
def: "A lamina propria that is part of a mucosa of fundus of stomach." []
synonym: "lamina propria mucosae of fundus of stomach" EXACT []
is_a: UBERON:0004780 ! gastrointestinal system lamina propria
is_a: UBERON:0009034 ! stomach region
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0004994 ! mucosa of fundus of stomach
relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach

[Term]
id: UBERON:0016512
name: lumen of duodenum
def: "A anatomical space that is part of a duodenum." []
synonym: "doudenal lumen" EXACT []
synonym: "duodenal lumen" EXACT []
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: UBERON:0016517
name: lumen of jejunum
def: "A anatomical space that is part of a jejunum." []
synonym: "jejunal lumen" EXACT []
synonym: "jejunum lumen" EXACT []
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum

[Term]
id: UBERON:0016520
name: epithelium of female urethra
def: "A epithelium that is part of a female urethra." []
synonym: "female urethral epithelium" EXACT []
synonym: "urethral epithelium of female" EXACT []
is_a: UBERON:0002325 ! epithelium of urethra
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: part_of UBERON:0001334 ! female urethra

[Term]
id: UBERON:0016525
name: frontal lobe
def: "Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border." []
synonym: "frontal cortex" NARROW []
synonym: "frontal region" BROAD []
synonym: "lobi frontales" EXACT []
synonym: "lobus frontalis" EXACT []
synonym: "regio frontalis" BROAD []
is_a: UBERON:0016526 ! lobe of cerebral hemisphere

[Term]
id: UBERON:0016526
name: lobe of cerebral hemisphere
def: "Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified]." []
synonym: "cerebral cortical segment" RELATED []
synonym: "cerebral hemisphere lobe" EXACT []
synonym: "cerebral lobe" EXACT []
synonym: "lobe of cerebral cortex" EXACT []
synonym: "lobe parts of cerebral cortex" EXACT []
synonym: "lobes of the brain" RELATED []
synonym: "lobi cerebri" EXACT []
synonym: "regional organ part of cerebral cortex" RELATED []
synonym: "segment of cerebral cortex" RELATED []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001869 ! cerebral hemisphere

[Term]
id: UBERON:0016527
name: white matter of cerebral lobe
is_a: UBERON:0002437 ! cerebral hemisphere white matter
intersection_of: UBERON:0002437 ! cerebral hemisphere white matter
intersection_of: part_of UBERON:0016526 ! lobe of cerebral hemisphere
relationship: part_of UBERON:0016526 ! lobe of cerebral hemisphere

[Term]
id: UBERON:0016528
name: white matter of frontal lobe
def: "A white matter of cerebral lobe that is part of a frontal lobe." []
synonym: "frontal lobe white matter" EXACT []
is_a: UBERON:0016527 ! white matter of cerebral lobe
intersection_of: UBERON:0016527 ! white matter of cerebral lobe
intersection_of: part_of UBERON:0016525 ! frontal lobe
relationship: part_of UBERON:0016525 ! frontal lobe

[Term]
id: UBERON:0016529
name: cortex of cerebral lobe
def: "Grey matter neocortex region of a lobe of the cerebral hemisphere." []
synonym: "cortex of cerebral hemisphere lobe" EXACT []
synonym: "cortex of lobe of cerebral hemisphere" EXACT []
synonym: "gray matter of lobe of cerebral hemisphere" RELATED []
synonym: "neocortical part of cerebral hemisphere" RELATED []
is_a: UBERON:0005401 ! cerebral hemisphere gray matter
intersection_of: UBERON:0005401 ! cerebral hemisphere gray matter
intersection_of: part_of UBERON:0001950 ! neocortex
intersection_of: part_of UBERON:0016526 ! lobe of cerebral hemisphere
relationship: part_of UBERON:0001950 ! neocortex
relationship: part_of UBERON:0016526 ! lobe of cerebral hemisphere

[Term]
id: UBERON:0016536
name: white matter of limbic lobe
def: "A white matter of cerebral lobe that is part of a limbic lobe." []
is_a: UBERON:0016527 ! white matter of cerebral lobe
intersection_of: UBERON:0016527 ! white matter of cerebral lobe
intersection_of: part_of UBERON:0002600 ! limbic lobe
relationship: part_of UBERON:0002600 ! limbic lobe

[Term]
id: UBERON:0016542
name: limbic cortex
synonym: "cortex of limbic lobe" EXACT []
synonym: "gray matter of limbic lobe" RELATED []
synonym: "limbic lobe cortex" EXACT []
is_a: UBERON:0016529 ! cortex of cerebral lobe
intersection_of: UBERON:0016529 ! cortex of cerebral lobe
intersection_of: part_of UBERON:0002600 ! limbic lobe
relationship: part_of UBERON:0002600 ! limbic lobe

[Term]
id: UBERON:0016545
name: pharyngeal ectoderm
def: "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." []
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0003351 ! pharyngeal epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: part_of UBERON:0000076 ! external ectoderm
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0016548
name: central nervous system gray matter layer
def: "A layer of of the central nervous system that is part of gray matter." []
synonym: "CNS gray matter layer" EXACT []
synonym: "CNS grey matter layer" EXACT []
synonym: "gray matter layer of neuraxis" EXACT []
synonym: "grey matter layer" BROAD []
synonym: "grey matter layer of neuraxis" EXACT []
is_a: UBERON:0022303 ! nervous system cell part layer

[Term]
id: UBERON:0016550
name: spinal cord column
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0002240 ! spinal cord

[Term]
id: UBERON:0016554
name: white matter of midbrain
def: "A white matter that is part of the midbrain." []
synonym: "mesencephalic white matter" EXACT []
is_a: UBERON:0003544 ! brain white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain

[Term]
id: UBERON:0016565
name: cerebral blood vessel
def: "A blood vessel that is part of a cerebellum." []
is_a: UBERON:0003499 ! brain blood vessel
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0008998 ! vasculature of brain

[Term]
id: UBERON:0016566
name: pit
def: "An roughly circular indentation in a surface." []
is_a: UBERON:0006984 ! anatomical surface

[Term]
id: UBERON:0016570
name: lamina of gray matter of spinal cord
synonym: "rexed lamina" EXACT []
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0022303 ! nervous system cell part layer
intersection_of: UBERON:0022303 ! nervous system cell part layer
intersection_of: part_of UBERON:0002315 ! gray matter of spinal cord
relationship: part_of UBERON:0002315 ! gray matter of spinal cord

[Term]
id: UBERON:0016611
name: auditory hillocks, pharyngeal arch 1 derived
def: "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." []
is_a: UBERON:0000477 ! anatomical cluster
intersection_of: UBERON:0000477 ! anatomical cluster
intersection_of: develops_from UBERON:0004362 ! pharyngeal arch 1
intersection_of: part_of UBERON:0006208 ! auditory hillocks
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0006208 ! auditory hillocks

[Term]
id: UBERON:0016612
name: auditory hillocks, pharyngeal arch 2 derived
def: "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." []
is_a: UBERON:0000477 ! anatomical cluster
intersection_of: UBERON:0000477 ! anatomical cluster
intersection_of: develops_from UBERON:0003066 ! pharyngeal arch 2
intersection_of: part_of UBERON:0006208 ! auditory hillocks
relationship: develops_from UBERON:0003066 ! pharyngeal arch 2
relationship: part_of UBERON:0006208 ! auditory hillocks

[Term]
id: UBERON:0016879
name: future central nervous system
def: "Primordium that develops into the central nervous system" []
synonym: "future CNS" EXACT []
synonym: "presumptive central nervous system" EXACT []
is_a: UBERON:0006598 ! presumptive structure
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0016880 ! future nervous system

[Term]
id: UBERON:0016880
name: future nervous system
def: "Primordium that develops into the nervous system" []
synonym: "presumptive nervous system" EXACT []
is_a: UBERON:0006598 ! presumptive structure
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: UBERON:0016884
name: shoulder joint
def: "The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints" []
synonym: "joint of shoulder region" EXACT []
is_a: UBERON:0000982 ! skeletal joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0001467 ! shoulder
relationship: develops_from UBERON:0006292 ! shoulder joint primordium
relationship: part_of UBERON:0001467 ! shoulder

[Term]
id: UBERON:0016885
name: epithelium of terminal part of digestive tract
def: "Epithelium lining the distalmost portion of the digestive tract." []
synonym: "rectum epithelium" NARROW []
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0006866 ! terminal part of digestive tract
relationship: part_of UBERON:0006866 ! terminal part of digestive tract

[Term]
id: UBERON:0016886
name: muscle tissue of terminal part of digestive tract
def: "Any muscle tissue of the distalmost portion of the digestive tract." []
synonym: "rectum muscle" NARROW []
synonym: "rectum muscle structure" NARROW []
is_a: UBERON:0002385 ! muscle tissue
intersection_of: UBERON:0002385 ! muscle tissue
intersection_of: part_of UBERON:0006866 ! terminal part of digestive tract
relationship: part_of UBERON:0006866 ! terminal part of digestive tract

[Term]
id: UBERON:0016887
name: entire extraembryonic component
def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." []
synonym: "extra-embryonic component" EXACT []
synonym: "extraembryonic component" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0004716 ! conceptus

[Term]
id: UBERON:0016888
name: transitional anatomical structure
def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." []
is_a: UBERON:0005423 ! developing anatomical structure

[Term]
id: UBERON:0016896
name: periosteum of long bone
def: "A periosteum that is part of a long bone." []
synonym: "long bone periosteum" EXACT []
is_a: UBERON:0002515 ! periosteum
intersection_of: UBERON:0002515 ! periosteum
intersection_of: part_of UBERON:0002495 ! long bone
relationship: part_of UBERON:0002495 ! long bone

[Term]
id: UBERON:0017650
name: developing mesenchymal structure
def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." []
is_a: UBERON:0005423 ! developing anatomical structure

[Term]
id: UBERON:0017672
name: abdominal viscera
def: "A viscus that is part of a abdomen." []
synonym: "abdominal viscera" EXACT []
synonym: "abdominal viscera set" EXACT []
synonym: "set of abdominal viscera" EXACT []
is_a: UBERON:0002075 ! viscus
is_a: UBERON:0005172 ! abdomen element
intersection_of: UBERON:0002075 ! viscus
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen

[Term]
id: UBERON:0018111
name: muscle layer of rectum
def: "A muscle layer that is part of the rectum" []
synonym: "muscular coat of rectum" EXACT []
synonym: "muscularis externa of rectum" EXACT []
synonym: "rectal muscularis propria" EXACT []
synonym: "tunica muscularis (rectum)" EXACT []
synonym: "tunica muscularis recti" EXACT []
is_a: UBERON:0011198 ! muscle layer of large intestine
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0018112
name: rectum smooth muscle tissue
def: "Any portion of smooth muscle tissue that is part of the rectum" []
synonym: "rectal smooth muscle tissue" EXACT []
synonym: "rectum smooth muscle" EXACT []
synonym: "smooth muscle of rectum" EXACT []
is_a: UBERON:0004220 ! large intestine smooth muscle
is_a: UBERON:0004231 ! anal region smooth muscle
is_a: UBERON:0016886 ! muscle tissue of terminal part of digestive tract
intersection_of: UBERON:0001135 ! smooth muscle tissue
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: UBERON:0018154
name: ligament of middle ear
def: "A ligament that is part of a middle ear." []
is_a: UBERON:0000211 ! ligament
intersection_of: UBERON:0000211 ! ligament
intersection_of: part_of UBERON:0001756 ! middle ear
relationship: part_of UBERON:0001756 ! middle ear

[Term]
id: UBERON:0018226
name: pulmonary part of lymphatic system
def: "An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels." []
synonym: "pulmonary lymphatic chain" EXACT []
synonym: "pulmonary lymphatic vasculature" RELATED []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: part_of UBERON:0002048 ! lung
intersection_of: part_of UBERON:0006558 ! lymphatic part of lymphoid system
relationship: has_part UBERON:0018227 ! pulmonary lymphatic vessel
relationship: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system

[Term]
id: UBERON:0018227
name: pulmonary lymphatic vessel
def: "A lymphatic vessel that is part of a lung." []
synonym: "lymphatic vessel of lung" EXACT []
is_a: UBERON:0003456 ! respiratory system lymphatic vessel
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0018226 ! pulmonary part of lymphatic system

[Term]
id: UBERON:0018234
name: stroma of pancreas
def: "A stroma that is part of a pancreas." []
synonym: "pancreatic stroma" EXACT []
is_a: UBERON:0003891 ! stroma
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0018235
name: capsule of pancreas
def: "A capsule that divides the parenchyma of the pancreas into lobes and lobules" []
synonym: "pancreatic capsule" EXACT []
is_a: UBERON:0003893 ! capsule
intersection_of: UBERON:0003893 ! capsule
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: UBERON:0018254
name: skeletal musculature
is_a: UBERON:0000061 ! anatomical structure
relationship: part_of UBERON:0000383 ! musculature of body

[Term]
id: UBERON:0018257
name: submucosa of digestive tract
def: "Any portion of submucosa that lines the digestive tract." []
is_a: UBERON:0000009 ! submucosa
intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0018260
name: layer of muscle tissue
def: "Any organ component layer that consists of muscle tissue." []
is_a: UBERON:0004923 ! organ component layer

[Term]
id: UBERON:0018261
name: muscular coat of digestive tract
def: "A muscular coat that is part of a digestive tract." []
synonym: "muscular layer of digestive tract" RELATED []
synonym: "muscularis externa of digestive tract" RELATED []
synonym: "tunica externa of digestive tract" RELATED []
synonym: "tunica muscularis of digestive tract" EXACT []
is_a: UBERON:0006660 ! muscular coat
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract

[Term]
id: UBERON:0018303
name: adrenal tissue
def: "Tissue that is part of some adrenal gland" []
synonym: "adrenal gland tissue" EXACT []
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: UBERON:0000479 ! tissue
intersection_of: part_of UBERON:0002369 ! adrenal gland
relationship: part_of UBERON:0002369 ! adrenal gland

[Term]
id: UBERON:0018649
name: cardiac muscle tissue of ventricle
synonym: "ventricular cardiac muscle tissue" EXACT []
synonym: "ventricular heart muscle" EXACT []
synonym: "ventricular muscle" RELATED []
is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium
intersection_of: UBERON:0001133 ! cardiac muscle tissue
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0001083 ! myocardium of ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle

[Term]
id: UBERON:0018664
name: neck of bone element
def: "the neck region of a bone organ." []
synonym: "bone neck" EXACT []
synonym: "neck of bone" EXACT []
is_a: UBERON:0001560 ! neck of organ
is_a: UBERON:0005913 ! zone of bone organ
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element

[Term]
id: UBERON:0018674
name: heart vasculature
def: "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." []
synonym: "cardiac vasculature" EXACT []
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: UBERON:0018707
name: bladder organ
def: "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." []
synonym: "bladder" NARROW []
is_a: UBERON:0000489 ! cavitated compound organ
is_a: UBERON:0009856 ! sac

[Term]
id: UBERON:0019042
name: reproductive system mucosa
synonym: "genital mucosa" EXACT []
is_a: UBERON:0000344 ! mucosa
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0000990 ! reproductive system
relationship: part_of UBERON:0000990 ! reproductive system

[Term]
id: UBERON:0019143
name: intramuscular adipose tissue
def: "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." []
synonym: "intramuscular fat" RELATED []
is_a: UBERON:0001013 ! adipose tissue
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: part_of UBERON:0014892 ! skeletal muscle organ
relationship: part_of UBERON:0014892 ! skeletal muscle organ

[Term]
id: UBERON:0019189
name: carotid artery endothelium
synonym: "carotid endothelium" RELATED []
synonym: "carotid epithelium" RELATED []
is_a: UBERON:0001917 ! endothelium of artery
intersection_of: UBERON:0001986 ! endothelium
intersection_of: part_of UBERON:0005396 ! carotid artery segment
relationship: part_of UBERON:0005396 ! carotid artery segment

[Term]
id: UBERON:0019190
name: mucous gland of lung
synonym: "bronchial gland" EXACT []
synonym: "bronchial mucous gland" EXACT []
synonym: "peribronchial gland" EXACT []
is_a: UBERON:0000414 ! mucous gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005181 ! thoracic segment organ
intersection_of: UBERON:0000414 ! mucous gland
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0019204
name: skin epithelium
def: "Any region of epithelium that is part of a skin region." []
is_a: UBERON:0010371 ! ecto-epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000014 ! zone of skin
relationship: part_of UBERON:0000014 ! zone of skin

[Term]
id: UBERON:0019207
name: chorioretinal region
def: "The part of the eye that consists of both the retina and the optic choroid" []
synonym: "chorioretina" EXACT []
synonym: "choroid and retina" EXACT []
synonym: "retinachoroid" EXACT []
synonym: "retinachoroidal region" EXACT []
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: has_part UBERON:0000966 ! retina
relationship: has_part UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0010230 ! eyeball of camera-type eye

[Term]
id: UBERON:0019258
name: white matter of hindbrain
def: "A white matter that is part of the hindbrain." []
is_a: UBERON:0003544 ! brain white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0019261
name: white matter of forebrain
def: "A white matter that is part of the forebrain." []
is_a: UBERON:0003544 ! brain white matter
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0019262
name: white matter of myelencephalon
def: "A white matter that is part of the myelencephalon." []
synonym: "myelencephalic white matter" EXACT []
is_a: UBERON:0019258 ! white matter of hindbrain
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0005290 ! myelencephalon
relationship: part_of UBERON:0005290 ! myelencephalon

[Term]
id: UBERON:0019263
name: gray matter of hindbrain
synonym: "gray matter of the hindbrain" EXACT []
is_a: UBERON:0003528 ! brain gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0002028 ! hindbrain
relationship: part_of UBERON:0002028 ! hindbrain

[Term]
id: UBERON:0019264
name: gray matter of forebrain
is_a: UBERON:0003528 ! brain gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain

[Term]
id: UBERON:0019267
name: gray matter of midbrain
is_a: UBERON:0003528 ! brain gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0001891 ! midbrain

[Term]
id: UBERON:0019269
name: gray matter of diencephalon
is_a: UBERON:0019264 ! gray matter of forebrain
intersection_of: UBERON:0002020 ! gray matter
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001894 ! diencephalon

[Term]
id: UBERON:0019291
name: white matter of metencephalon
is_a: UBERON:0019258 ! white matter of hindbrain
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0001895 ! metencephalon
relationship: part_of UBERON:0001895 ! metencephalon

[Term]
id: UBERON:0019304
name: sensory organ epithelium
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000020 ! sense organ
relationship: part_of UBERON:0000020 ! sense organ

[Term]
id: UBERON:0019306
name: nose epithelium
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0019304 ! sensory organ epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0000004 ! nose

[Term]
id: UBERON:0019319
name: exocrine gland of integumental system
def: "An exocrine gland that is part of a integumental system." []
synonym: "integumental exocrine gland" EXACT []
synonym: "integumental system exocrine gland" EXACT []
is_a: UBERON:0002365 ! exocrine gland
is_a: UBERON:0003297 ! gland of integumental system
intersection_of: UBERON:0002365 ! exocrine gland
intersection_of: part_of UBERON:0002416 ! integumental system
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0022279
name: strand of hair on external ear
synonym: "hair of external ear" EXACT []
synonym: "hair of tragus" EXACT []
synonym: "tragus hair" EXACT []
is_a: UBERON:0016446 ! hair of head
intersection_of: UBERON:0001037 ! strand of hair
intersection_of: part_of UBERON:0001691 ! external ear
relationship: part_of UBERON:0001691 ! external ear

[Term]
id: UBERON:0022280
name: epithelium of crypt of Lieberkuhn of small intestine
synonym: "epithelium of small intestinal crypt of Lieberkuhn" EXACT []
synonym: "wall of small intestinal crypt of Lieberkuhn" RELATED []
is_a: UBERON:0001902 ! epithelium of small intestine
is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine
relationship: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine

[Term]
id: UBERON:0022281
name: epithelium of crypt of Lieberkuhn of large intestine
is_a: UBERON:0001278 ! epithelium of large intestine
is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine
relationship: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine

[Term]
id: UBERON:0022284
name: lacrimal gland bud
def: "the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland)" []
is_a: UBERON:0005153 ! epithelial bud
is_a: UBERON:0015808 ! eye epithelium
relationship: part_of UBERON:0001750 ! lacrimal apparatus

[Term]
id: UBERON:0022292
name: splenic arteriole
is_a: UBERON:0001980 ! arteriole
is_a: UBERON:0003497 ! abdomen blood vessel
intersection_of: UBERON:0001980 ! arteriole
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:0022303
name: nervous system cell part layer
def: "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." []
synonym: "lamina" BROAD []
synonym: "layer" BROAD []
is_a: UBERON:0005162 ! multi cell part structure
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0022350
name: visceral serous membrane
def: "Serous membrane layer that is adjacent to and lines an organ." []
synonym: "visceral wall of serous membrane" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0000042 ! serous membrane

[Term]
id: UBERON:0022351
name: parietal serous membrane
def: "Serous membrane layer that lines to a body cavity." []
synonym: "cavity lining" BROAD []
synonym: "parietal wall of serous membrane" EXACT []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0004923 ! organ component layer
relationship: part_of UBERON:0000042 ! serous membrane

[Term]
id: UBERON:0022357
name: mesentery of ileum
synonym: "ileal mesentery" EXACT []
synonym: "ileum mesentery" EXACT []
synonym: "mesoileum" EXACT []
is_a: UBERON:0001170 ! mesentery of small intestine
intersection_of: UBERON:0002095 ! mesentery
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0002116 ! ileum

[Term]
id: UBERON:0022358
name: placenta blood vessel
synonym: "placental vessel" BROAD []
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0001981 ! blood vessel
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta

[Term]
id: UBERON:0022360
name: male mammary gland duct
def: "A mammary gland duct that is part of a male organism. This structure typically regresses." []
is_a: UBERON:0001765 ! mammary duct
intersection_of: UBERON:0001765 ! mammary duct
intersection_of: part_of UBERON:0003101 ! male organism
relationship: part_of UBERON:0003101 ! male organism

[Term]
id: UBERON:0024045
name: white matter of the cerebellar cortex
def: "White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei." []
synonym: "white matter of the cerebellar cortex" EXACT []
is_a: UBERON:0019291 ! white matter of metencephalon
intersection_of: UBERON:0002316 ! white matter
intersection_of: part_of UBERON:0002129 ! cerebellar cortex
relationship: part_of UBERON:0002129 ! cerebellar cortex

[Term]
id: UBERON:0034705
name: developing neuroepithelium
def: "An embryonic or larval epithelium that is committed to form part of the nervous system." []
synonym: "embryonic neuroepithelium" EXACT []
synonym: "neurepithelium" BROAD []
synonym: "neuroepithelium" EXACT []
is_a: UBERON:0000483 ! epithelium
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0034706
name: proliferating neuroepithelium
def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." []
is_a: UBERON:0034705 ! developing neuroepithelium

[Term]
id: UBERON:0034707
name: differentiating neuroepithelium
def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." []
is_a: UBERON:0034705 ! developing neuroepithelium

[Term]
id: UBERON:0034713
name: cranial neuron projection bundle
def: "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain" []
synonym: "cranial nerve fiber bundle" RELATED []
synonym: "cranial nerve fiber tract" RELATED []
synonym: "cranial nerve or tract" RELATED []
synonym: "neuron projection bundle from brain" RELATED []
is_a: UBERON:0000122 ! neuron projection bundle

[Term]
id: UBERON:0034728
name: autonomic nerve
def: "The splanchnic nerves are paired nerves that contribute to the innervation of the viscera, carrying fibers of the autonomic nervous system as well as sensory fibers from the organs. All carry sympathetic fibers except for the pelvic splanchnic nerves, which carry parasympathetic fibers." []
synonym: "nervus visceralis" EXACT []
synonym: "visceral nerve" EXACT []
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 ! autonomic nervous system

[Term]
id: UBERON:0034768
name: morphological feature
def: "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." []
is_a: UBERON:0000061 ! anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0034769
name: lymphomyeloid tissue
is_a: UBERON:0015757 ! heterogeneous tissue

[Term]
id: UBERON:0034907
name: pineal parenchyma
def: "Parenchymal tissue that forms the pineal gland." []
is_a: UBERON:0005158 ! parenchyma of central nervous system
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0001905 ! pineal body
relationship: part_of UBERON:0001905 ! pineal body

[Term]
id: UBERON:0034921
name: multi organ part structure
def: "An multicellular anatomical structure that has subparts of multiple organs as a part." []
synonym: "anatomical cluster" RELATED []
is_a: UBERON:0010000 ! multicellular anatomical structure

[Term]
id: UBERON:0034922
name: cell cluster
def: "A cluster of cells, largely surrounded by a morphological boundary." []
is_a: UBERON:0010000 ! multicellular anatomical structure

[Term]
id: UBERON:0034923
name: disconnected anatomical group
def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." []
is_a: UBERON:0000465 ! material anatomical entity

[Term]
id: UBERON:0034925
name: anatomical collection
def: "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." []
is_a: UBERON:0000465 ! material anatomical entity

[Term]
id: UBERON:0034926
name: anatomical row
def: "An anatomical collection that is arranged in a line." []
is_a: UBERON:0034925 ! anatomical collection

[Term]
id: UBERON:0034929
name: external soft tissue zone
def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." []
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: has_part UBERON:0000014 ! zone of skin
relationship: has_part UBERON:0001015 ! musculature
relationship: has_part UBERON:0001021 ! nerve
relationship: has_part UBERON:0002049 ! vasculature
relationship: part_of UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0034932
name: epithelium of biliary system
def: "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." []
synonym: "biliary epithelium" RELATED []
synonym: "biliary system epithelium" EXACT []
synonym: "biliary tract epithelium" RELATED []
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002294 ! biliary system
relationship: part_of UBERON:0002294 ! biliary system

[Term]
id: UBERON:0034933
name: layer of smooth muscle tissue
def: "Any organ component layer that consists of smooth muscle tissue." []
is_a: UBERON:0018260 ! layer of muscle tissue

[Term]
id: UBERON:0034944
name: zone of organ
synonym: "organ region with floating fiat boundary" RELATED []
synonym: "organ sector" EXACT []
synonym: "organ zonal region" EXACT []
synonym: "organ zone" EXACT []
is_a: UBERON:0000064 ! organ part

[Term]
id: UBERON:0034969
name: epithelial layer of duct
synonym: "duct epithelium" RELATED []
synonym: "ductal epithelium" RELATED []
is_a: UBERON:0003914 ! epithelial tube
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000058 ! duct
relationship: part_of UBERON:0000058 ! duct

[Term]
id: UBERON:0034978
name: paraganglion (generic)
def: "A cluster of neuroendocrine cells derived from neural crest. Paraganglia may be chromaffin or nonchromaffin" []
synonym: "paraganglia" RELATED []
is_a: UBERON:0010001 ! cell cluster organ
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from UBERON:0002342 ! neural crest

[Term]
id: UBERON:0034995
name: jaw mesenchyme
def: "Mesenchyme that is part of a developing jaw [Automatically generated definition]." []
is_a: UBERON:0005253 ! head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0011595 ! jaw region
relationship: part_of UBERON:0011595 ! jaw region

[Term]
id: UBERON:0034996
name: outer renal medulla loop of henle
synonym: "loop of Henle, outer medullary portion" EXACT []
is_a: UBERON:0034997 ! renal medulla loop of henle
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney

[Term]
id: UBERON:0034997
name: renal medulla loop of henle
synonym: "loop of Henle of renal medulla" EXACT []
synonym: "loop of Henle, medullary portion" EXACT []
is_a: UBERON:0001288 ! loop of Henle
intersection_of: UBERON:0001288 ! loop of Henle
intersection_of: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla

[Term]
id: UBERON:0035034
name: eyelid epithelium
def: "An epithelium that is part of an eyelid [Automatically generated definition]." []
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid

[Term]
id: UBERON:0035037
name: jaw epithelium
is_a: UBERON:0003929 ! digestive tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0011595 ! jaw region
relationship: part_of UBERON:0011595 ! jaw region

[Term]
id: UBERON:0035049
name: excretory duct of salivary gland
def: "Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized]." []
is_a: UBERON:0001837 ! duct of salivary gland
is_a: UBERON:0035050 ! excretory duct
intersection_of: UBERON:0035050 ! excretory duct
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland

[Term]
id: UBERON:0035050
name: excretory duct
is_a: UBERON:0000058 ! duct

[Term]
id: UBERON:0035053
name: interlobular duct of salivary gland
is_a: UBERON:0014716 ! interlobular duct
is_a: UBERON:0035049 ! excretory duct of salivary gland
intersection_of: UBERON:0014716 ! interlobular duct
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland

[Term]
id: UBERON:0035073
name: duct of eccrine sweat gland
synonym: "ductal part of eccrine sweat gland" EXACT []
is_a: UBERON:0000058 ! duct
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0000423 ! eccrine sweat gland
relationship: part_of UBERON:0000423 ! eccrine sweat gland

[Term]
id: UBERON:0035075
name: thymus subunit
synonym: "lobe or lobule of thymus" RELATED []
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000063 ! organ subunit
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: part_of UBERON:0002046 ! thyroid gland

[Term]
id: UBERON:0035128
name: manus cartilage element
synonym: "hand cartilage condensation" EXACT []
is_a: UBERON:0010883 ! forelimb cartilage element
is_a: UBERON:0015064 ! autopod cartilage
relationship: develops_from UBERON:0009523 ! mesenchyme of handplate
relationship: part_of UBERON:0002398 ! manus

[Term]
id: UBERON:0035129
name: pes cartilage element
synonym: "foot cartilage condensation" EXACT []
is_a: UBERON:0010885 ! hindlimb cartilage element
is_a: UBERON:0015064 ! autopod cartilage
relationship: develops_from UBERON:0003328 ! mesenchyme of footplate
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:0035267
name: neck of gallbladder
def: "The narrowest portion of the gallbladder and distal to the cystic duct." []
synonym: "cervix of gallbladder" EXACT []
synonym: "gallbladder neck" EXACT []
is_a: UBERON:0001560 ! neck of organ
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0002110 ! gall bladder
relationship: part_of UBERON:0002110 ! gall bladder

[Term]
id: UBERON:0035316
name: prostatic capsule
def: "The membrane the surrounds the prostate gland." []
synonym: "capsule of prostate" EXACT []
synonym: "capsule of prostate gland" EXACT []
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003893 ! capsule
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003893 ! capsule
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland

[Term]
id: UBERON:0035553
name: left cardiac chamber
def: "Any chamber of the left side of the heart" []
is_a: UBERON:0004151 ! cardiac chamber
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0035554
name: right cardiac chamber
def: "Any chamber of the right side of the heart" []
is_a: UBERON:0004151 ! cardiac chamber
is_a: UBERON:0015212 ! lateral structure

[Term]
id: UBERON:0035555
name: lateral line sense organ
is_a: UBERON:0010521 ! electroreceptor organ
relationship: part_of UBERON:0002540 ! lateral line system

[Term]
id: UBERON:0035606
name: cartilage of external acoustic meatus
synonym: "cartilage of acoustic meatus" EXACT []
synonym: "cartilage of auditory canal" EXACT []
synonym: "cartilago meatus acustici" EXACT []
synonym: "external acoustic meatus cartilage" EXACT []
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0034944 ! zone of organ
intersection_of: UBERON:0034944 ! zone of organ
intersection_of: part_of UBERON:0001352 ! external acoustic meatus
intersection_of: part_of UBERON:0001867 ! cartilage of external ear
relationship: part_of UBERON:0001352 ! external acoustic meatus
relationship: part_of UBERON:0001867 ! cartilage of external ear

[Term]
id: UBERON:0035639
name: ocular adnexa
def: "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva" []
synonym: "accessory parts of orbital region" RELATED []
synonym: "accessory visual structures" RELATED []
synonym: "accessory visual structures set" RELATED []
synonym: "adnexa oculi" EXACT []
synonym: "adnexal parts of orbital region" RELATED []
synonym: "appendage of eye" RELATED []
synonym: "appendages of the eye" RELATED []
synonym: "eye adnexa" RELATED []
synonym: "set of accessory visual structures" RELATED []
synonym: "structurae oculi accessoriae" RELATED []
is_a: UBERON:0000477 ! anatomical cluster
relationship: part_of UBERON:0004088 ! orbital region

[Term]
id: UBERON:0035764
name: pulmonary lymph node
synonym: "intrapulmonary lymph node" EXACT []
synonym: "pulmonary node" EXACT []
is_a: UBERON:0000029 ! lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0008886 ! pulmonary vascular system
relationship: part_of UBERON:0008886 ! pulmonary vascular system

[Term]
id: UBERON:0035767
name: intrapulmonary bronchus
is_a: UBERON:0002185 ! bronchus
intersection_of: UBERON:0002185 ! bronchus
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0035804
name: future mouth
def: "The primordial mouth region of the developing head." []
synonym: "primitive mouth" EXACT []
synonym: "primordial mouth" EXACT []
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0013522 ! subdivision of tube
relationship: has_part UBERON:0000925 ! endoderm
relationship: has_part UBERON:0000930 ! stomodeum
relationship: part_of UBERON:0007026 ! presumptive gut

[Term]
id: UBERON:0035805
name: muscle layer of sigmoid colon
def: "A muscle layer that is part of the sigmoid colon" []
synonym: "muscularis externa of sigmoid colon" EXACT []
synonym: "muscularis propria of sigmoid colon" EXACT []
synonym: "sigmoid colon muscularis propria" EXACT []
synonym: "sigmoideum muscularis" RELATED []
synonym: "tunica muscularis colon sigmoideum" RELATED []
is_a: UBERON:0012489 ! muscle layer of colon
intersection_of: UBERON:0006660 ! muscular coat
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon

[Term]
id: UBERON:0035809
name: serous cavity
is_a: UBERON:0002553 ! anatomical cavity

[Term]
id: UBERON:0035820
name: peritoneal sac
def: "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." []
synonym: "peritoneal component" RELATED []
is_a: UBERON:0005906 ! serous sac
relationship: has_part UBERON:0001179 ! peritoneal cavity
relationship: has_part UBERON:0002358 ! peritoneum

[Term]
id: UBERON:1000021
name: skin of face
def: "A zone of skin that is part of the face." []
synonym: "face skin" EXACT []
synonym: "facial skin" RELATED []
is_a: UBERON:0001084 ! skin of head
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001456 ! face
relationship: part_of UBERON:0001456 ! face

[Term]
id: UBERON:1000023
name: spleen pulp
def: "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." []
synonym: "malpighian corpuscles" EXACT []
synonym: "pulp of spleen" EXACT []
synonym: "splenic pulp" EXACT []
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:1000024 ! parenchyma of spleen

[Term]
id: UBERON:1000024
name: parenchyma of spleen
def: "A parenchyma that is part of a spleen." []
synonym: "splenic parenchyma" EXACT []
is_a: UBERON:0000353 ! parenchyma
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen

[Term]
id: UBERON:2000120
name: lateral line ganglion
def: "Ganglion that develops from a cranial ectodermal placode and contains sensory neurons that innervate a lateral line." []
synonym: "lateral line ganglia" EXACT []
synonym: "LLG" EXACT []
is_a: UBERON:0001714 ! cranial ganglion
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from UBERON:0009128 ! lateral line placode
relationship: part_of UBERON:0002540 ! lateral line system

[Term]
id: UBERON:2000175
name: posterior lateral line nerve
def: "Cranial nerve which enters the brain between cranial nerves VIII and IX; contains afferents and sensory efferents to the posterior lateral line ganglion and middle ganglion. Fibers from the posterior lateral line ganglion innervate the occipital dorsal lateral line and trunk lateral lines." []
synonym: "caudal lateral line nerve" EXACT []
is_a: UBERON:0008906 ! lateral line nerve
relationship: part_of UBERON:2001471 ! posterior lateral line system

[Term]
id: UBERON:2000228
name: lateral line primordium
synonym: "lateral line primordia" EXACT []
synonym: "llp" EXACT []
is_a: UBERON:0000479 ! tissue
relationship: part_of UBERON:0002540 ! lateral line system

[Term]
id: UBERON:2000425
name: anterior lateral line nerve
def: "Cranial nerve which enters the brain between cranial nerves VI and VII; contains afferents and sensory efferents to the anterior lateral line ganglia." []
synonym: "rostral lateral line nerve" EXACT []
is_a: UBERON:0008906 ! lateral line nerve
relationship: part_of UBERON:2001468 ! anterior lateral line system

[Term]
id: UBERON:2001156
name: posterior lateral line placode
is_a: UBERON:0003067 ! dorsolateral placode
disjoint_from: UBERON:2001316 ! anterior lateral line placode
relationship: part_of UBERON:2001471 ! posterior lateral line system

[Term]
id: UBERON:2001314
name: posterior lateral line ganglion
def: "The posterior lateral line ganglion develops from a cranial ectodermal placode and contains sensory neurons that innervate the posterior lateral line system." []
is_a: UBERON:2000120 ! lateral line ganglion
disjoint_from: UBERON:2001391 ! anterior lateral line ganglion
relationship: develops_from UBERON:2001156 ! posterior lateral line placode

[Term]
id: UBERON:2001316
name: anterior lateral line placode
def: "Dorsolateral placode that gives rise to the anterior lateral line." []
synonym: "anterior lateral line placodes" RELATED []
synonym: "pre-auditory lateral line placode" RELATED []
is_a: UBERON:0003067 ! dorsolateral placode
intersection_of: UBERON:0003067 ! dorsolateral placode
intersection_of: part_of UBERON:2001468 ! anterior lateral line system
relationship: part_of UBERON:2001468 ! anterior lateral line system

[Term]
id: UBERON:2001391
name: anterior lateral line ganglion
def: "The anteror lateral line ganglia develops from cranial ectodermal placodes and contain sensory neurons that innervate the anterior lateral line system." []
synonym: "anterior lateral line ganglia" RELATED []
is_a: UBERON:2000120 ! lateral line ganglion
intersection_of: UBERON:2000120 ! lateral line ganglion
intersection_of: part_of UBERON:2001468 ! anterior lateral line system
relationship: part_of UBERON:2001468 ! anterior lateral line system

[Term]
id: UBERON:2001468
name: anterior lateral line system
def: "The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." []
is_a: UBERON:0002540 ! lateral line system
disjoint_from: UBERON:2001471 ! posterior lateral line system

[Term]
id: UBERON:2001470
name: anterior lateral line
def: "The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." []
is_a: UBERON:0010202 ! lateral line
intersection_of: UBERON:0010202 ! lateral line
intersection_of: part_of UBERON:2001468 ! anterior lateral line system
relationship: develops_from UBERON:2005117 ! anterior lateral line primordium
relationship: part_of UBERON:2001468 ! anterior lateral line system

[Term]
id: UBERON:2001471
name: posterior lateral line system
def: "The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." []
is_a: UBERON:0002540 ! lateral line system

[Term]
id: UBERON:2005117
name: anterior lateral line primordium
def: "A migrating group of cells originating from an anterior lateral line placode. The primordium deposits neuromasts and interneuromasts between them during its migration." []
synonym: "anterior lateral line primordia" EXACT []
is_a: UBERON:2000228 ! lateral line primordium
relationship: part_of UBERON:2001468 ! anterior lateral line system

[Term]
id: UBERON:2005260
name: fenestrated capillary
def: "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse" []
synonym: "fenestrated blood vessel endothelium" BROAD []
synonym: "fenestrated capillary vessel" EXACT []
is_a: UBERON:0001982 ! capillary
is_a: UBERON:0004638 ! blood vessel endothelium

[Term]
id: UBERON:2007013
name: preplacodal ectoderm
def: "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." []
is_a: UBERON:0005497 ! non-neural ectoderm

[Term]
id: UBERON:3000961
name: external integument structure
def: "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." []
is_a: UBERON:0003102 ! surface structure
intersection_of: UBERON:0003102 ! surface structure
intersection_of: part_of UBERON:0002199 ! integument
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:3000972
name: head external integument structure
def: "Dermal, epidermal, glandular and pigment structures of the external head integument." []
is_a: UBERON:3000961 ! external integument structure
intersection_of: UBERON:3000961 ! external integument structure
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:3000977
name: body external integument structure
def: "Dermal, epidermal, glandular and pigment structures of the body integument." []
is_a: UBERON:3000961 ! external integument structure
intersection_of: UBERON:3000961 ! external integument structure
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:3000981
name: limb external integument structure
def: "Dermal, epidermal, glandular and pigment structures of the limb integument." []
is_a: UBERON:3000961 ! external integument structure
intersection_of: UBERON:3000961 ! external integument structure
intersection_of: part_of UBERON:0002101 ! limb
relationship: part_of UBERON:0002101 ! limb

[Term]
id: UBERON:3010200
name: vasculature of respiratory integument
def: "Blood vessels in respiratory skin." []
is_a: UBERON:0003504 ! respiratory system blood vessel
intersection_of: UBERON:0001981 ! blood vessel
intersection_of: part_of UBERON:0001004 ! respiratory system
intersection_of: part_of UBERON:0002199 ! integument
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0002199 ! integument

[Term]
id: UBERON:4000013
name: mineralized skeletal tissue
def: "Skeletal tissue that is mineralized." []
synonym: "mineralized tissue" BROAD []
is_a: UBERON:0004755 ! skeletal tissue

[Term]
id: UBERON:4100000
name: skeletal element projection
def: "Anatomical projection that is composed of bone or cartilage tissue." []
is_a: UBERON:0004529 ! anatomical projection
intersection_of: UBERON:0004529 ! anatomical projection
intersection_of: part_of UBERON:0004765 ! skeletal element
relationship: part_of UBERON:0004765 ! skeletal element

[Term]
id: UBERON:5001466
name: pedal digit plus metapodial segment
def: "A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." []
synonym: "pedal digit" BROAD []
synonym: "pedal digit ( phalanges plus metapodial) plus soft tissue" BROAD []
synonym: "pedal digit digitopodial subdivision" EXACT []
synonym: "pedal digit ray" EXACT []
is_a: UBERON:5002544 ! digit plus metapodial segment
intersection_of: UBERON:5002544 ! digit plus metapodial segment
intersection_of: part_of UBERON:0002387 ! pes
relationship: has_part UBERON:0001466 ! pedal digit
relationship: part_of UBERON:0002387 ! pes

[Term]
id: UBERON:5002389
name: manual digit plus metapodial segment
def: "A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." []
synonym: "manual digit" BROAD []
synonym: "manual digit ( phalanges plus metapodial) plus soft tissue" BROAD []
synonym: "manual digit digitopodial subdivision" EXACT []
synonym: "manual digit ray" EXACT []
is_a: UBERON:5002544 ! digit plus metapodial segment
intersection_of: UBERON:5002544 ! digit plus metapodial segment
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: has_part UBERON:0002389 ! manual digit
relationship: part_of UBERON:0002102 ! forelimb

[Term]
id: UBERON:5002544
name: digit plus metapodial segment
def: "A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." []
synonym: "digit" BROAD []
synonym: "digit ( phalanges plus metapodial) plus soft tissue" BROAD []
synonym: "digit digitopodial subdivision" EXACT []
synonym: "digit ray" EXACT []
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0002544 ! digit
relationship: part_of UBERON:0012140 ! digitopodium region

[Term]
id: UBERON:5101466
name: pedal digit digitopodial skeleton
def: "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element." []
synonym: "pedal digit" RELATED []
synonym: "pedal digit skeleton" RELATED []
is_a: UBERON:5102544 ! individual digit of digitopodial skeleton
relationship: part_of UBERON:0012150 ! skeleton of digitopodium
relationship: part_of UBERON:5001466 ! pedal digit plus metapodial segment

[Term]
id: UBERON:5102389
name: manual digit digitopodial skeleton
def: "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element." []
synonym: "manual digit" RELATED []
synonym: "manual digit skeleton" RELATED []
is_a: UBERON:5102544 ! individual digit of digitopodial skeleton
relationship: part_of UBERON:0012150 ! skeleton of digitopodium
relationship: part_of UBERON:5002389 ! manual digit plus metapodial segment

[Term]
id: UBERON:5102544
name: individual digit of digitopodial skeleton
def: "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." []
synonym: "digit" RELATED []
synonym: "digit skeleton" RELATED []
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010712 ! limb skeleton subdivision
relationship: part_of UBERON:0012150 ! skeleton of digitopodium
relationship: part_of UBERON:5002544 ! digit plus metapodial segment

[Term]
id: http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33
name: alobate nucleus
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: bearer_of PATO:0002506 ! alobate
relationship: bearer_of PATO:0002506 ! alobate

[Typedef]
id: adjacent_to
name: adjacent to
def: "x adjacent to y if and only if x and y share a boundary" []
xref: RO:0002220
domain: BFO:0000004 ! independent continuant
range: BFO:0000004 ! independent continuant
is_a: spatially_disjoint_from ! spatially disjoint from

[Typedef]
id: bearer_of
name: bearer of
def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" []
xref: RO:0000053
range: BFO:0000020 ! specifically dependent continuant

[Typedef]
id: capable_of
name: capable of
def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
xref: RO:0002215
domain: BFO:0000004 ! independent continuant
range: BFO:0000015 ! process
is_a: capable_of_part_of ! capable of part of

[Typedef]
id: capable_of_negatively_regulating
name: capable of negatively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." []
xref: RO:0002597
holds_over_chain: capable_of negatively_regulates
is_a: capable_of_regulating ! capable of regulating

[Typedef]
id: capable_of_part_of
name: capable of part of
def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." []
xref: RO:0002216
holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
is_a: causal_agent_in ! causal agent in
is_a: functionally_related_to ! functionally related to

[Typedef]
id: capable_of_positively_regulating
name: capable of positively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." []
xref: RO:0002598
holds_over_chain: capable_of positively_regulates
is_a: capable_of_regulating ! capable of regulating

[Typedef]
id: capable_of_regulating
name: capable of regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." []
xref: RO:0002596
holds_over_chain: capable_of regulates
is_a: causal_agent_in ! causal agent in

[Typedef]
id: causal_agent_in
name: causal agent in
def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" []
xref: RO:0002500
is_a: causal_relation_between_material_entity_and_a_process ! causal relation between material entity and a process
inverse_of: has_causal_agent ! has causal agent

[Typedef]
id: causal_relation_between_material_entity_and_a_process
name: causal relation between material entity and a process
def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." []
xref: RO:0002595
domain: BFO:0000040 ! material entity
range: BFO:0000015 ! process
is_a: causally_related_to ! causally related to

[Typedef]
id: causal_relation_between_processes
name: causal relation between processes
def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." []
xref: RO:0002501
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
is_a: causally_related_to ! causally related to

[Typedef]
id: causally_downstream_of_or_within
name: causally downstream of or within
xref: RO:0002427
is_transitive: true
is_a: causal_relation_between_processes ! causal relation between processes

[Typedef]
id: causally_related_to
name: causally related to
def: "This relation groups causal relations between material entities and causal relations between processes" []
xref: RO:0002410
is_a: related_via_dependence_to ! related via dependence to

[Typedef]
id: causally_upstream_of_or_within
name: causally upstream of or within
def: "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." []
xref: RO:0002418
is_transitive: true
is_a: causal_relation_between_processes ! causal relation between processes
inverse_of: causally_downstream_of_or_within ! causally downstream of or within

[Typedef]
id: contained_in
name: contained in
xref: RO:0001018
domain: BFO:0000040 ! material entity
range: BFO:0000004 ! independent continuant
holds_over_chain: located_in part_of
inverse_of: contains ! contains

[Typedef]
id: contains
name: contains
xref: RO:0001019

[Typedef]
id: contains_process
name: contains process
def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
xref: BFO:0000067

[Typedef]
id: depends_on
name: depends on
xref: RO:0002502

[Typedef]
id: developmentally_contributes_to
name: developmentally contributes to
xref: RO:0002255
holds_over_chain: develops_into part_of
is_a: developmentally_succeeded_by ! developmentally succeeded by
is_a: has_potential_to_developmentally_contribute_to ! has potential to developmentally contribute to

[Typedef]
id: developmentally_preceded_by
name: developmentally preceded by
def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" []
xref: RO:0002258
is_a: developmentally_related_to ! developmentally related to
inverse_of: developmentally_succeeded_by ! developmentally succeeded by

[Typedef]
id: developmentally_related_to
name: developmentally related to
def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" []
xref: RO:0002324

[Typedef]
id: developmentally_succeeded_by
name: developmentally succeeded by
def: "Inverse of developmentally preceded by" []
xref: RO:0002286
is_a: has_developmental_potential_involving ! has developmental potential involving

[Typedef]
id: develops_from
name: develops from
def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" []
xref: RO:0002202
domain: BFO:0000004 ! independent continuant
range: BFO:0000004 ! independent continuant
holds_over_chain: part_of develops_from
is_transitive: true
is_a: developmentally_preceded_by ! developmentally preceded by
inverse_of: develops_into ! develops into
transitive_over: part_of ! part of

[Typedef]
id: develops_into
name: develops into
xref: RO:0002203
is_transitive: true
is_a: developmentally_succeeded_by ! developmentally succeeded by
is_a: has_potential_to_develop_into ! has potential to develop into
is_a: has_potential_to_directly_develop_into ! has potential to directly develop into

[Typedef]
id: downstream_in_neural_circuit_with
name: downstream in neural circuit with
def: "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next." []
xref: RO:0000302
is_transitive: true
is_a: in_neural_circuit_with ! in neural circuit with

[Typedef]
id: functionally_related_to
name: functionally related to
xref: RO:0002328

[Typedef]
id: has_causal_agent
name: has causal agent
def: "Inverse of 'causal agent in'" []
xref: RO:0002608
is_a: causally_related_to ! causally related to

[Typedef]
id: has_completed
name: has_completed
xref: has_completed

[Typedef]
id: has_developmental_contribution_from
name: has developmental contribution from
def: "x has developmental contribution from y iff x has some part z such that z develops from y" []
xref: RO:0002254
domain: CARO:0000003 ! anatomical structure
range: CARO:0000003 ! anatomical structure
holds_over_chain: has_part develops_from
is_a: developmentally_preceded_by ! developmentally preceded by
inverse_of: developmentally_contributes_to ! developmentally contributes to

[Typedef]
id: has_developmental_potential_involving
name: has developmental potential involving
def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." []
xref: RO:0002384
is_a: developmentally_related_to ! developmentally related to

[Typedef]
id: has_high_plasma_membrane_amount
name: has_high_plasma_membrane_amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617]
xref: has_high_plasma_membrane_amount
is_a: has_plasma_membrane_part ! has plasma membrane part

[Typedef]
id: has_low_plasma_membrane_amount
name: has_low_plasma_membrane_amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617]
xref: has_low_plasma_membrane_amount
is_a: has_plasma_membrane_part ! has plasma membrane part

[Typedef]
id: has_not_completed
name: has_not_completed
xref: has_not_completed

[Typedef]
id: has_part
name: has part
def: "a core relation that holds between a whole and its part" []
xref: BFO:0000051
is_transitive: true
is_a: overlaps ! overlaps

[Typedef]
id: has_part_structure_that_is_capable_of
name: has part structure that is capable of
def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" []
xref: RO:0002584
holds_over_chain: has_part capable_of
is_a: causal_relation_between_material_entity_and_a_process ! causal relation between material entity and a process
is_a: functionally_related_to ! functionally related to

[Typedef]
id: has_part_that_occurs_in
name: has part that occurs in
def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." []
xref: RO:0002479
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}

[Typedef]
id: has_participant
name: has participant
def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" []
xref: RO:0000057
domain: BFO:0000003 ! occurrent
range: BFO:0000002 ! continuant
holds_over_chain: has_part has_participant

[Typedef]
id: has_plasma_membrane_part
name: has plasma membrane part
def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." []
xref: RO:0002104
is_a: has_part ! has part

[Typedef]
id: has_potential_to_develop_into
name: has potential to develop into
def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" []
xref: RO:0002387
is_a: has_developmental_potential_involving ! has developmental potential involving

[Typedef]
id: has_potential_to_developmentally_contribute_to
name: has potential to developmentally contribute to
def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" []
xref: RO:0002385
is_a: has_developmental_potential_involving ! has developmental potential involving

[Typedef]
id: has_potential_to_directly_develop_into
name: has potential to directly develop into
def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" []
xref: RO:0002388
is_a: has_potential_to_develop_into ! has potential to develop into

[Typedef]
id: has_relational_adjective
name: has_relational_adjective
namespace: uberon
comment: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
xref: UBPROP:0000007
is_metadata_tag: true

[Typedef]
id: has_soma_location
name: has soma location
def: "Relation between a neuron and an anatomical structure that its soma is part of." []
xref: RO:0002100
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part of

[Typedef]
id: has_synaptic_terminal_in
name: has synaptic terminal in
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
xref: RO:0002130
is_a: overlaps ! overlaps
transitive_over: part_of ! part of

[Typedef]
id: has_synaptic_terminal_of
name: has synaptic terminal of
xref: RO:0002006
is_a: overlaps ! overlaps
inverse_of: has_synaptic_terminal_in ! has synaptic terminal in

[Typedef]
id: immediate_transformation_of
name: immediate_transformation_of
synonym: "direct_transformation_of" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "immediately transforms from" EXACT [SIO:000658]
xref: http://semanticscience.org/resource/SIO_000658
property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl

[Typedef]
id: in_neural_circuit_with
name: in neural circuit with
def: "A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons." []
xref: RO:0000300
is_transitive: true

[Typedef]
id: inheres_in
name: inheres in
def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" []
xref: RO:0000052
is_a: inheres_in_part_of ! inheres in part of
inverse_of: bearer_of ! bearer of

[Typedef]
id: inheres_in_part_of
name: inheres in part of
def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." []
xref: RO:0002314
holds_over_chain: inheres_in part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
is_a: depends_on ! depends on
transitive_over: part_of ! part of

[Typedef]
id: innervated_by
name: innervated_by
xref: RO:0002005
inverse_of: innervates ! innervates

[Typedef]
id: innervates
name: innervates
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
xref: RO:0002134
domain: CARO:0001001 ! neuron projection bundle
transitive_over: part_of ! part of

[Typedef]
id: lacks_part
name: lacks_part
xref: lacks_part
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" []

[Typedef]
id: lacks_plasma_membrane_part
name: lacks_plasma_membrane_part
xref: lacks_plasma_membrane_part
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" []

[Typedef]
id: located_in
name: located in
def: "a relation between two independent continuants, the target and the location, in which the target is entirely within the location" []
xref: RO:0001025
is_transitive: true

[Typedef]
id: location_of
name: location of
def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" []
xref: RO:0001015
is_transitive: true
inverse_of: located_in ! located in

[Typedef]
id: mereotopologically_related_to
name: mereotopologically related to
def: "A mereological relationship or a topological relationship" []
xref: RO:0002323

[Typedef]
id: negatively_regulated_by
name: negatively regulated by
xref: RO:0002335
is_a: regulated_by ! regulated by

[Typedef]
id: negatively_regulates
name: negatively regulates
def: "x negatively regulates y if and only if the progression of x reduces the frequency, rate or extent of y" []
xref: RO:0002212
is_a: regulates ! regulates
inverse_of: negatively_regulated_by ! negatively regulated by

[Typedef]
id: occurs_in
name: occurs in
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
xref: BFO:0000066
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
holds_over_chain: part_of occurs_in
inverse_of: contains_process ! contains process
transitive_over: part_of ! part of

[Typedef]
id: overlaps
name: overlaps
def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" []
xref: RO:0002131
holds_over_chain: has_part overlaps
holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
holds_over_chain: part_of part_of
is_a: mereotopologically_related_to ! mereotopologically related to

[Typedef]
id: part_of
name: part of
def: "a core relation that holds between a part and its whole" []
xref: BFO:0000050
is_transitive: true
is_a: overlaps ! overlaps
inverse_of: has_part ! has part

[Typedef]
id: part_of_structure_that_is_capable_of
name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
xref: RO:0002329
holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
is_a: functionally_related_to ! functionally related to

[Typedef]
id: participates_in
name: participates in
def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" []
xref: RO:0000056
domain: BFO:0000002 ! continuant
range: BFO:0000003 ! occurrent
inverse_of: has_participant ! has participant

[Typedef]
id: positively_regulated_by
name: positively regulated by
xref: RO:0002336
is_a: regulated_by ! regulated by

[Typedef]
id: positively_regulates
name: positively regulates
def: "x positively regulates y if and only if the progression of x increases the frequency, rate or extent of y" []
xref: RO:0002213
holds_over_chain: negatively_regulates negatively_regulates
is_a: regulates ! regulates
inverse_of: positively_regulated_by ! positively regulated by

[Typedef]
id: produced_by
name: produced by
def: "a produced_by b iff some process that occurs_in b has_output a." []
xref: RO:0003001
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity

[Typedef]
id: produces
name: produces
def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." []
xref: RO:0003000
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
inverse_of: produced_by ! produced by

[Typedef]
id: regulated_by
name: regulated by
def: "inverse of regulates" []
xref: RO:0002334
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_transitive: true
is_a: causally_downstream_of_or_within ! causally downstream of or within

[Typedef]
id: regulates
name: regulates
def: "x regulates y if and only if the x is the realization of a function to exert an effect on the frequency, rate or extent of y" []
xref: RO:0002211
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_transitive: true
is_a: causally_upstream_of_or_within ! causally upstream of or within
inverse_of: regulated_by ! regulated by
transitive_over: part_of ! part of

[Typedef]
id: related_via_dependence_to
name: related via dependence to
def: "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." []
xref: RO:0002609

[Typedef]
id: seeAlso
name: see also
namespace: uberon
xref: http://www.w3.org/2000/01/rdf-schema#seeAlso
is_metadata_tag: true

[Typedef]
id: spatially_coextensive_with
name: spatially coextensive with
def: "x spatially_coextensive_with y if and inly if x and y have the same location" []
xref: RO:0002379
is_a: overlaps ! overlaps

[Typedef]
id: spatially_disjoint_from
name: spatially disjoint from
def: "A is spatially_disjoint_from B if and only if they have no parts in common" []
xref: RO:0002163
is_a: mereotopologically_related_to ! mereotopologically related to

[Typedef]
id: synapsed_by
name: synapsed by
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
xref: RO:0002103
is_a: upstream_in_neural_circuit_with ! upstream in neural circuit with
inverse_of: synapsed_to ! synapsed to

[Typedef]
id: synapsed_to
name: synapsed to
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n        " []
xref: RO:0002120
is_a: downstream_in_neural_circuit_with ! downstream in neural circuit with

[Typedef]
id: upstream_in_neural_circuit_with
name: upstream in neural circuit with
def: "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next." []
xref: RO:0000301
is_transitive: true
is_a: in_neural_circuit_with ! in neural circuit with