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com.fulcrumgenomics.vcf.api.AlleleSet.scala Maven / Gradle / Ivy
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/*
* The MIT License
*
* Copyright (c) 2019 Fulcrum Genomics LLC
*
* Permission is hereby granted, free of charge, to any person obtaining a copy
* of this software and associated documentation files (the "Software"), to deal
* in the Software without restriction, including without limitation the rights
* to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
* copies of the Software, and to permit persons to whom the Software is
* furnished to do so, subject to the following conditions:
*
* The above copyright notice and this permission notice shall be included in
* all copies or substantial portions of the Software.
*
* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
* IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
* FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
* AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
* LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
* OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
* THE SOFTWARE.
*/
package com.fulcrumgenomics.vcf.api
import com.fulcrumgenomics.FgBioDef._
import com.fulcrumgenomics.vcf.api.Allele.SimpleAllele
/**
* Simple class to encapsulate a set of alleles where one allele represents the allele
* that is present in the reference genome, and the remainder represent alternative alleles.
*
* @param ref the reference allele
* @param alts the ordered list of alternate alleles
*/
case class AlleleSet(ref: SimpleAllele, alts: IndexedSeq[Allele]) extends Iterable[Allele] {
/** Provides an iterator over all the alleles. */
override def iterator: Iterator[Allele] = Iterator(ref) ++ alts.iterator
/** Retrives the allele at `index`. The reference allele is given index 0, and alternate
* alleles are indexed starting at 1. Requesting an index `< 1` or `> size-1` will result
* in a [[IndexOutOfBoundsException]].
*
* @param index The index of the allele to return
* @return the allele present at the index
*/
def apply(index: Int): Allele = if (index == 0) ref else alts(index-1)
/** Returns the position of the given allele within the allele set. */
def indexOf(a: Allele): Int = if (a == ref) 0 else alts.indexOf(a) + 1
/** The number of alleles, including reference, in the set. */
override def size: Int = alts.size + 1
}
object AlleleSet {
private val NoAlts: IndexedSeq[Allele] = IndexedSeq.empty
/**
* Generates an AlleleSet from a reference allele and zero or more alternative alleles.
*
* @param ref the reference allele; if this is not a [[SimpleAllele]] an [[IllegalArgumentException]]
* will be thrown. The parameter type is [[Allele]] to avoid callers having to cast.
* @param alts zero or more alternative alleles
*/
def apply(ref: Allele, alts: Iterable[Allele]): AlleleSet = ref match {
case r: SimpleAllele => AlleleSet(r, alts.toIndexedSeq)
case _ => throw new IllegalArgumentException(s"Cannot have a non-simple ref allele: $ref")
}
/**
* Generates an AlleleSet from a reference allele and zero or more alternative alleles.
*
* @param ref the reference allele; if this is not a [[SimpleAllele]] an [[IllegalArgumentException]]
* will be thrown. The parameter type is [[Allele]] to avoid callers having to cast.
* @param alts zero or more alternative alleles
*/
def apply(ref: Allele, alts: Allele*): AlleleSet = apply(ref, alts)
/**
* Generates an AlleleSet from one or more String alleles. The first allele will be the reference
* allele and must be composed of regular bases.
*
* @param alleles one or more allele strings
*/
def apply(alleles: String*): AlleleSet = {
require(alleles.nonEmpty, "Must provide at least one allele.")
AlleleSet(Allele(alleles.head), alleles.drop(1).map(s => Allele(s)))
}
}
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