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package picard.util;
import htsjdk.samtools.util.Interval;
import htsjdk.samtools.util.IntervalList;
import java.util.ArrayDeque;
import java.util.ArrayList;
import java.util.Collections;
import java.util.List;
/**
* @author mccowan
*/
public class IntervalListScatterer {
public enum Mode {
/**
* A simple scatter approach in which all output intervals have size equal to the total base count of the source list divided by the
* scatter count (except, possibly, in the last interval list).
*/
INTERVAL_SUBDIVISION,
/**
* A scatter approach that differs from {@link Mode#INTERVAL_SUBDIVISION} in a few ways:
*
*
No interval will be subdivided, and consequently, the requested {@link IntervalListTools#SCATTER_COUNT} is
* an upper bound of scatter count, not a guarante of the number of {@link IntervalList}s that will be produced
* (e.g., if scatterCount = 10 but there is only one interval in the input, only 1 interval list will be emitted).
*
When an interval would otherwise be split, it is instead deferred to the next scatter list.
*
The "target width" of each scatter list may be wider than what is computed for {@link Mode#INTERVAL_SUBDIVISION}.
* Specifically, if the widest interval in the source interval list is larger than what would otherwise be the target width, that
* interval's width is used.
This approach produces more consistently-sized interval lists, which is one of
* the objectives of scattering.
*
*/
BALANCING_WITHOUT_INTERVAL_SUBDIVISION,
/**
* A scatter approach that differs from {@link Mode#BALANCING_WITHOUT_INTERVAL_SUBDIVISION}.
*
* This approach tries to balance the number of bases in each interval list by estimating the remaining interval lists sizes. This is
* computed from the total number of unique bases and the bases we have consumed. This means that the interval list with the most
* number of unique bases is at most the ideal split length larger than the smallest interval list (unique number of bases).
*/
BALANCING_WITHOUT_INTERVAL_SUBDIVISION_WITH_OVERFLOW
}
private final Mode mode;
public IntervalListScatterer(final Mode mode) {this.mode = mode;}
private int deduceIdealSplitLength(final IntervalList uniquedList, final int scatterCount) {
final int splitWidth = Math.max((int) Math.floor(uniquedList.getBaseCount() / (1.0 * scatterCount)), 1);
switch (mode) {
case INTERVAL_SUBDIVISION:
return splitWidth;
case BALANCING_WITHOUT_INTERVAL_SUBDIVISION:
case BALANCING_WITHOUT_INTERVAL_SUBDIVISION_WITH_OVERFLOW:
final int widestIntervalLength = Collections.max(uniquedList.getIntervals(), (o1, o2) -> Integer.valueOf(o1.length()).compareTo(o2.length())).length();
// There is no purpose to splitting more granularly than the widest interval, so do not.
return Math.max(widestIntervalLength, splitWidth);
default:
throw new IllegalStateException();
}
}
public List scatter(final IntervalList uniquedIntervalList, final int scatterCount) {
return scatter(uniquedIntervalList, scatterCount, false);
}
/** Helper for the scatter method */
private boolean shouldAddToRunningIntervalList(final long idealSplitLength, final long projectedSize, final double projectedSizeOfRemainingDivisions) {
switch (mode) {
case BALANCING_WITHOUT_INTERVAL_SUBDIVISION_WITH_OVERFLOW:
return (projectedSize <= idealSplitLength || idealSplitLength < projectedSizeOfRemainingDivisions);
default:
return (projectedSize <= idealSplitLength);
}
}
public List scatter(final IntervalList sourceIntervalList, final int scatterCount, final boolean isUniqued) {
if (scatterCount < 1) throw new IllegalArgumentException("scatterCount < 1");
final IntervalList uniquedList = isUniqued ? sourceIntervalList : sourceIntervalList.uniqued();
final long idealSplitLength = deduceIdealSplitLength(uniquedList, scatterCount);
System.err.println("idealSplitLength=" + idealSplitLength);
final List accumulatedIntervalLists = new ArrayList<>();
IntervalList runningIntervalList = new IntervalList(uniquedList.getHeader());
final ArrayDeque intervalQueue = new ArrayDeque<>(uniquedList.getIntervals());
long numBasesLeft = uniquedList.getBaseCount();
while (!intervalQueue.isEmpty() && accumulatedIntervalLists.size() < scatterCount - 1) {
final Interval interval = intervalQueue.pollFirst();
final long projectedSize = runningIntervalList.getBaseCount() + interval.length();
// The mean expected size of the remaining divisions
// NOTE: that this looks like double counting but isn't, we subtract here the bases that are in the _current_ running intervalList,
// and when we create a new intervalList (below) we modify numBasesLeft.
// Another Note: the -1 in the denominator is for "runningIntervalList" that isn't yet counted in accumulatedIntervalLists.size()
final double projectedSizeOfRemainingDivisions = (numBasesLeft - runningIntervalList.getBaseCount()) / ((double)(scatterCount - accumulatedIntervalLists.size() - 1));
// should we add this interval to the list of running intervals?
if (shouldAddToRunningIntervalList(idealSplitLength, projectedSize, projectedSizeOfRemainingDivisions)) {
runningIntervalList.add(interval);
}
else {
switch (mode) {
case INTERVAL_SUBDIVISION:
final int amountToConsume = (int) (idealSplitLength - runningIntervalList.getBaseCount());
final Interval left = new Interval(
interval.getContig(),
interval.getStart(),
interval.getStart() + amountToConsume - 1,
interval.isNegativeStrand(),
interval.getName()
);
final Interval right = new Interval(
interval.getContig(),
interval.getStart() + amountToConsume,
interval.getEnd(),
interval.isNegativeStrand(),
interval.getName()
);
runningIntervalList.add(left);
// Push back the excess back onto our queue for reconsideration.
intervalQueue.addFirst(right);
break;
case BALANCING_WITHOUT_INTERVAL_SUBDIVISION:
case BALANCING_WITHOUT_INTERVAL_SUBDIVISION_WITH_OVERFLOW:
if (runningIntervalList.getIntervals().isEmpty()) {
runningIntervalList.add(interval);
} else {
// Push this interval into the next scatter; re-inject it into the queue, then advance the scatter.
intervalQueue.addFirst(interval);
numBasesLeft -= runningIntervalList.getBaseCount();
accumulatedIntervalLists.add(runningIntervalList.uniqued());
runningIntervalList = new IntervalList(uniquedList.getHeader());
}
break;
}
}
if (runningIntervalList.getBaseCount() >= idealSplitLength) {
numBasesLeft -= runningIntervalList.getBaseCount(); // keep track of the number of *unique* bases left
accumulatedIntervalLists.add(runningIntervalList.uniqued());
runningIntervalList = new IntervalList(uniquedList.getHeader());
}
}
// Flush the remaining intervals into the last split.
while (!intervalQueue.isEmpty()) {
runningIntervalList.add(intervalQueue.pollFirst());
}
if (!runningIntervalList.getIntervals().isEmpty()) {
accumulatedIntervalLists.add(runningIntervalList.uniqued());
}
long maximumIntervalSize = -1, minimumIntervalSize = Integer.MAX_VALUE;
for (final IntervalList intervalList : accumulatedIntervalLists) {
final long baseCount = intervalList.getBaseCount();
if (baseCount < minimumIntervalSize) minimumIntervalSize = baseCount;
if (maximumIntervalSize < baseCount) maximumIntervalSize = baseCount;
}
return accumulatedIntervalLists;
}
}
