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/*
 * The MIT License
 *
 * Copyright (c) 2010 The Broad Institute
 *
 * Permission is hereby granted, free of charge, to any person obtaining a copy
 * of this software and associated documentation files (the "Software"), to deal
 * in the Software without restriction, including without limitation the rights
 * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
 * copies of the Software, and to permit persons to whom the Software is
 * furnished to do so, subject to the following conditions:
 *
 * The above copyright notice and this permission notice shall be included in
 * all copies or substantial portions of the Software.
 *
 * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
 * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
 * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
 * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
 * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
 * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
 * THE SOFTWARE.
 */
package picard.util;

import htsjdk.samtools.SAMFileHeader;
import htsjdk.samtools.SamReaderFactory;
import htsjdk.samtools.liftover.LiftOver;
import htsjdk.samtools.util.IOUtil;
import htsjdk.samtools.util.Interval;
import htsjdk.samtools.util.IntervalList;
import htsjdk.samtools.util.Log;
import picard.cmdline.CommandLineProgram;
import picard.cmdline.CommandLineProgramProperties;
import picard.cmdline.Option;
import picard.cmdline.StandardOptionDefinitions;
import picard.cmdline.programgroups.Intervals;

import java.io.File;
import java.util.List;

/**
 * @author [email protected]
 */
@CommandLineProgramProperties(
        usage = LiftOverIntervalList.USAGE_SUMMARY + LiftOverIntervalList.USAGE_DETAILS,
        usageShort = LiftOverIntervalList.USAGE_SUMMARY,
        programGroup = Intervals.class
)
public class LiftOverIntervalList extends CommandLineProgram {
    static final String USAGE_SUMMARY = "Lifts over an interval list from one reference build to another.  ";
    static final String USAGE_DETAILS = "This tool adjusts the coordinates in an interval list derived from one reference to match " +
            "a new reference, based on a chain file that describes the correspondence between the two references. It is based on the " +
            "UCSC liftOver tool (see: http://genome.ucsc.edu/cgi-bin/hgLiftOver) and uses a UCSC chain file to guide its operation. " +
            "It accepts both Picard interval_list files or VCF files as interval inputs." +
            "
" + "

Usage example:

" + "
" +
            "java -jar picard.jar LiftOverIntervalList \\
" + " I=input.interval_list \\
" + " O=output.interval_list \\
" + " SD=reference_sequence.dict \\
" + " CHAIN=build.chain" + "
" + "
"; private static final Log LOG = Log.getInstance(LiftOverIntervalList.class); @Option(doc = "Interval list to be lifted over.", shortName = StandardOptionDefinitions.INPUT_SHORT_NAME) public File INPUT; @Option(doc = "Where to write lifted-over interval list.", shortName = StandardOptionDefinitions.OUTPUT_SHORT_NAME) public File OUTPUT; @Option(doc = "Sequence dictionary to write into the output interval list.", shortName = StandardOptionDefinitions.SEQUENCE_DICTIONARY_SHORT_NAME) public File SEQUENCE_DICTIONARY; @Option(doc = "Chain file that guides LiftOver.") public File CHAIN; @Option(doc = "Minimum percentage of bases in each input interval that must map to output interval.") public double MIN_LIFTOVER_PCT = LiftOver.DEFAULT_LIFTOVER_MINMATCH; public static void main(final String[] argv) { new LiftOverIntervalList().instanceMainWithExit(argv); } /** * Do the work after command line has been parsed. RuntimeException may be * thrown by this method, and are reported appropriately. * * @return program exit status. */ @Override protected int doWork() { IOUtil.assertFileIsReadable(INPUT); IOUtil.assertFileIsReadable(SEQUENCE_DICTIONARY); IOUtil.assertFileIsReadable(CHAIN); IOUtil.assertFileIsWritable(OUTPUT); final LiftOver liftOver = new LiftOver(CHAIN); liftOver.setLiftOverMinMatch(MIN_LIFTOVER_PCT); final IntervalList fromIntervals = IntervalList.fromFile(INPUT); final SAMFileHeader toHeader = SamReaderFactory.makeDefault().getFileHeader(SEQUENCE_DICTIONARY); liftOver.validateToSequences(toHeader.getSequenceDictionary()); final IntervalList toIntervals = new IntervalList(toHeader); boolean anyFailed = false; for (final Interval fromInterval : fromIntervals) { final Interval toInterval = liftOver.liftOver(fromInterval); if (toInterval != null) { toIntervals.add(toInterval); } else { anyFailed = true; LOG.warn("Liftover failed for ", fromInterval, "(len ", fromInterval.length(), ")"); final List partials = liftOver.diagnosticLiftover(fromInterval); for (final LiftOver.PartialLiftover partial : partials) { LOG.info(partial); } } } toIntervals.sorted().write(OUTPUT); return anyFailed ? 1 : 0; } }




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