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package com.hfg.bio.glyco;


import java.awt.Color;
import java.awt.geom.Point2D;
import java.util.ArrayList;
import java.util.List;
import java.util.Set;
import java.util.HashSet;

import com.hfg.chem.Element;
import com.hfg.chem.Molecule;
import com.hfg.graphics.Shape;
import com.hfg.svg.SvgAttr;
import com.hfg.svg.SvgCircle;
import com.hfg.svg.SvgNode;
import com.hfg.svg.SvgPolygon;
import com.hfg.svg.SvgRect;
import com.hfg.graphics.ColorUtil;
import com.hfg.util.CompareUtil;
import com.hfg.util.StringUtil;

//------------------------------------------------------------------------------
/**
 Monosaccharide values.
 
See https://en.wikipedia.org/wiki/Monosaccharide
See http://www.genome.jp/kegg/catalog/codes2.html
@author J. Alex Taylor, hairyfatguy.com
*/ //------------------------------------------------------------------------------ // com.hfg XML/HTML Coding Library // // This library is free software; you can redistribute it and/or // modify it under the terms of the GNU Lesser General Public // License as published by the Free Software Foundation; either // version 2.1 of the License, or (at your option) any later version. // // This library is distributed in the hope that it will be useful, // but WITHOUT ANY WARRANTY; without even the implied warranty of // MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU // Lesser General Public License for more details. // // You should have received a copy of the GNU Lesser General Public // License along with this library; if not, write to the Free Software // Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA 02111-1307 USA // // J. Alex Taylor, President, Founder, CEO, COO, CFO, OOPS hairyfatguy.com // [email protected] //------------------------------------------------------------------------------ public class Monosaccharide extends Molecule { //########################################################################## // PUBLIC FIELDS //########################################################################## // Hexoses /** Generic hexose. */ public static final Monosaccharide Hexose = new Monosaccharide("Hexose", "Hex", Shape.CIRCLE, Color.WHITE); public static final Monosaccharide Galactose = new Monosaccharide("Galactose", "Gal", Shape.CIRCLE, new Color(255, 255, 0)); // Yellow public static final Monosaccharide Glucose = new Monosaccharide("Glucose", "Glc", Shape.CIRCLE, new Color(0, 0, 250)); // Blue public static final Monosaccharide Mannose = new Monosaccharide("Mannose", "Man", Shape.CIRCLE, new Color(0, 200, 50)); // Green // Deoxysugar (hexose or pentose without a hydroxyl group at the 6-position or the 2-position) public static final Monosaccharide Fucose = new Monosaccharide("Fucose", "Fuc", Shape.TRIANGLE, new Color(250, 0, 0)); // Red // Pentoses public static final Monosaccharide Xylose = new Monosaccharide("Xylose", "Xyl", Shape.STAR, new Color(250, 234, 213)); // Orange // Amino sugar (hexose with an N-acetylated amino group at the 2-position) public static final Monosaccharide HexNAc = new Monosaccharide("Hexosamine", "HexNac", Shape.SQUARE, Color.WHITE); public static final Monosaccharide GalNAc = new Monosaccharide("N-acetyl-D-galactosamine", "GalNAc", Shape.SQUARE, new Color(255, 255, 0)); // Yellow public static final Monosaccharide GlcNAc = new Monosaccharide("N-acetyl-D-glucosamine", "GlcNAc", Shape.SQUARE, new Color(0, 0, 250)); // Blue public static final Monosaccharide ManNAc = new Monosaccharide("N-Acetylmannosamine", "ManNAc", Shape.SQUARE, new Color(0, 200, 50)); // Green // Sialic acids public static final Monosaccharide NeuAc = new Monosaccharide("Neuraminic acid", "NeuAc", Shape.DIAMOND, new Color(200, 0, 200)); // Purple public static final Monosaccharide NeuGc = new Monosaccharide("N-glycolylneuraminic acid", "NeuGc", Shape.DIAMOND, new Color(233, 255, 255)); // Light blue public static final Monosaccharide KDN = new Monosaccharide("Deaminated neuraminic acid", "KDN", Shape.DIAMOND, new Color(0, 200, 50)); // Green public static final Monosaccharide GlcA = new Monosaccharide("D-Glucuronic acid", "GlcA", Shape.DIAMOND, new Color(0, 0, 250)); // Blue //########################################################################## // PRIVATE FIELDS //########################################################################## private String mName; private String mAbbrev; private Color mColor; private Shape mShape; // This declaration has to come before the public constants below. private static Set sValues = new HashSet<>(); static { Hexose.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 12) .addAtoms(Element.OXYGEN, 6) .lock() .register(); Galactose.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 12) .addAtoms(Element.OXYGEN, 6) .lock() .register(); Glucose.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 12) .addAtoms(Element.OXYGEN, 6) .lock() .register(); Mannose.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 12) .addAtoms(Element.OXYGEN, 6) .lock() .register(); Fucose.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 12) .addAtoms(Element.OXYGEN, 5) .lock() .register(); Xylose.addAtoms(Element.CARBON, 5) .addAtoms(Element.HYDROGEN, 10) .addAtoms(Element.OXYGEN, 5) .lock() .register(); HexNAc.addAtoms(Element.CARBON, 8) .addAtoms(Element.HYDROGEN, 15) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 6) .lock() .register(); GalNAc.addAtoms(Element.CARBON, 8) .addAtoms(Element.HYDROGEN, 15) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 6) .lock() .register(); GlcNAc.addAtoms(Element.CARBON, 8) .addAtoms(Element.HYDROGEN, 15) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 6) .lock() .register(); ManNAc.addAtoms(Element.CARBON, 8) .addAtoms(Element.HYDROGEN, 15) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 6) .lock() .register(); NeuAc.addAtoms(Element.CARBON, 11) .addAtoms(Element.HYDROGEN, 19) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 9) .lock() .register(); NeuGc.addAtoms(Element.CARBON, 11) .addAtoms(Element.HYDROGEN, 19) .addAtoms(Element.NITROGEN, 1) .addAtoms(Element.OXYGEN, 10) .lock() .register(); KDN.addAtoms(Element.CARBON, 9) .addAtoms(Element.HYDROGEN, 16) .addAtoms(Element.OXYGEN, 9) .lock() .register(); GlcA.addAtoms(Element.CARBON, 6) .addAtoms(Element.HYDROGEN, 10) .addAtoms(Element.OXYGEN, 7) .lock() .register(); } //########################################################################## // CONSTRUCTORS //########################################################################## //-------------------------------------------------------------------------- private Monosaccharide(String inName, String inAbbrev) { mName = inName; mAbbrev = inAbbrev; } //-------------------------------------------------------------------------- private Monosaccharide(String inName, String inAbbrev, Shape inShape, Color inColor) { this(inName, inAbbrev); mShape = inShape; mColor = inColor; } //########################################################################## // PUBLIC METHODS //########################################################################## //-------------------------------------------------------------------------- public static Monosaccharide valueOf(String inString) { Monosaccharide value = null; if (StringUtil.isSet(inString)) { for (Monosaccharide monosaccharide : sValues) { if (monosaccharide.name().equalsIgnoreCase(inString) || monosaccharide.getAbbrev().equals(inString)) { value = monosaccharide; break; } } } return value; } //-------------------------------------------------------------------------- public static Monosaccharide[] values() { return sValues.toArray(new Monosaccharide[sValues.size()]); } //-------------------------------------------------------------------------- /** Puts the Monosaccharide into the Set of unique Monosaccharide returned by Monosaccharide.values(). */ public void register() { if (! isLocked()) { throw new RuntimeException("Only locked Monosaccharides can be added to the values list!"); } sValues.add(this); } //-------------------------------------------------------------------------- @Override public Monosaccharide addAtoms(Element inElement, int inCount) { return (Monosaccharide) super.addAtoms(inElement, inCount); } //-------------------------------------------------------------------------- @Override public Monosaccharide addAtoms(Element inElement, float inCount) { return (Monosaccharide) super.addAtoms(inElement, inCount); } //-------------------------------------------------------------------------- @Override public Monosaccharide lock() { return (Monosaccharide) super.lock(); } //-------------------------------------------------------------------------- public String name() { return mName; } //-------------------------------------------------------------------------- public String getAbbrev() { return mAbbrev; } //-------------------------------------------------------------------------- public Shape getShape() { return mShape; } //-------------------------------------------------------------------------- public Color getColor() { return mColor; } //-------------------------------------------------------------------------- @Override public String toString() { return mAbbrev; } //-------------------------------------------------------------------------- public SvgNode toSVGNode() { SvgNode svgNode = null; if (Shape.SQUARE.equals(getShape())) { svgNode = new SvgRect().setWidth(10).setHeight(10); } else if (Shape.CIRCLE.equals(getShape())) { svgNode = new SvgCircle().setR(5); } else if (Shape.DIAMOND.equals(getShape())) { List points = new ArrayList<>(4); points.add(new Point2D.Float(0, 5)); points.add(new Point2D.Float(5, 10)); points.add(new Point2D.Float(10, 5)); points.add(new Point2D.Float(5, 0)); svgNode = new SvgPolygon(points); } else if (Shape.TRIANGLE.equals(getShape())) { List points = new ArrayList<>(3); points.add(new Point2D.Float(0, 10)); points.add(new Point2D.Float(10, 10)); points.add(new Point2D.Float(5, 0)); svgNode = new SvgPolygon(points); } if (svgNode != null) { svgNode.setAttribute(SvgAttr.title, name()); svgNode.addStyle(SvgAttr.stroke + ": #000000"); svgNode.addStyle(SvgAttr.strokeWidth + ":1"); if (getColor() != null) { svgNode.addStyle(SvgAttr.fill + ": #" + ColorUtil.colorToHex(getColor())); } } return svgNode; } //-------------------------------------------------------------------------- @Override public int compareTo(Object inObj2) { int result = -1; if (inObj2 != null) { if (inObj2 instanceof Monosaccharide) { Monosaccharide monosaccharide2 = (Monosaccharide) inObj2; result = CompareUtil.compare(getAbbrev(), monosaccharide2.getAbbrev()); } else { result = CompareUtil.compare(hashCode(), inObj2.hashCode()); } } return result; } }




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