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Framework that allows defining file formats (layouts) and use them to read and write data files.
Item #
Length
Source of Standard
Year Implemented
Version Implemented
Year Retired
Version Retired
3940
1
NAACCR
2021
21
NAACCR XML: Tumor.brafMutationalAnalysis
Description
The BRAF oncoprotein is involved in transmitting cell growth and proliferation signals from KRAS and NRAS. The BRAF V600E mutation is associated with poorer prognosis and predicts lack of response to anti-EGFR therapies.
Rationale
BRAF mutational analysis is recommended in clinical guidelines for patients with advanced colorectal cancer as a prognostic marker and factor in determining appropriate therapy. It is a new data item for cases diagnosed 1/1/2021+.
Codes
0
Normal
BRAF negative, BRAF wild type
Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1
Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2
Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
4
Abnormal (mutated), NOS
7
Test ordered, results not in chart
8
Not applicable: Information not collected for this case
If this information is required by your standard setter, use of code 8 may result in an edit error.)
9
Not documented in medical record
BRAF not assessed or unknown if assessed
Each Site-Specific Data Item (SSDI) applies only to selected primary
sites, histologies, and years of diagnosis. Depending on applicability
and standard-setter requirements, SSDIs may be left blank.