layout.fixed.naaccr.doc.naaccr23.brafMutationalAnalysis.html Maven / Gradle / Ivy

Go to download

Show more of this group Show more artifacts with this name
Show all versions of layout Show documentation

Framework that allows defining file formats (layouts) and use them to read and write data files.

There is a newer version: 6.0


  
    Item #
    Length
    Source of Standard
    Year Implemented
    Version Implemented
    Year Retired
    Version Retired
  
  
    3940
    1
    NAACCR
    2021
    21
    
    
  



NAACCR XML: Tumor.brafMutationalAnalysis




Description
The BRAF oncoprotein is involved in transmitting cell growth and proliferation signals from KRAS and NRAS. The BRAF V600E mutation is associated with poorer prognosis and predicts lack of response to anti-EGFR therapies.
Rationale
BRAF mutational analysis is recommended in clinical guidelines for patients with advanced colorectal cancer as a prognostic marker and factor in determining appropriate therapy.  It is a new data item for cases diagnosed 1/1/2021+.
Codes
0 Normal

BRAF negative, BRAF wild type

Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1 Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2 Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
4 Abnormal (mutated), NOS
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case

If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record

BRAF not assessed or unknown if assessed
Blank Diagnosis year is prior to 2021 
Each Site-Specific Data Item (SSDI) applies only to selected primary 
sites, histologies, and years of diagnosis. Depending on applicability 
and standard-setter requirements, SSDIs may be left blank.

0	Normal BRAF negative, BRAF wild type Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1	Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2	Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
4	Abnormal (mutated), NOS
7	Test ordered, results not in chart
8	Not applicable: Information not collected for this case If this information is required by your standard setter, use of code 8 may result in an edit error.)
9	Not documented in medical record BRAF not assessed or unknown if assessed
Blank	Diagnosis year is prior to 2021