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Framework that allows defining file formats (layouts) and use them to read and write data files.

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        Item #
        Length
        Source of Standard
        Year Implemented
        Version Implemented
        Year Retired
        Version Retired
    
    
        3940
        1
        NAACCR
        2021
        21
        
        
    



NAACCR XML: Tumor.brafMutationalAnalysis




Description
The BRAF oncoprotein is involved in transmitting cell growth and proliferation signals from KRAS and NRAS. The BRAF V600E mutation is associated with poorer prognosis and predicts lack of response to anti-EGFR therapies.
Rationale
BRAF mutational analysis is recommended in clinical guidelines for patients with advanced colorectal cancer as a prognostic marker and factor in determining appropriate therapy.  It is a new data item for cases diagnosed 1/1/2021+.
Codes

    
        
            0
            Normal

                BRAF negative, BRAF wild type

                Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
            
        
        
            1
            Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
        
        
            2
            Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
        
        
            4
            Abnormal (mutated), NOS
        
        
            7
            Test ordered, results not in chart
        
        
            8
            Not applicable: Information not collected for this case

                If this information is required by your standard setter, use of code 8 may result in an edit error.)
            
        
        
            9
            Not documented in medical record

                BRAF not assessed or unknown if assessed
            
        
        
            Blank
            Diagnosis year is prior to 2021
        
        
            
        
    

Each Site-Specific Data Item (SSDI) applies only to selected primary
    sites, histologies, and years of diagnosis. Depending on applicability
    and standard-setter requirements, SSDIs may be left blank.

0	Normal BRAF negative, BRAF wild type Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1	Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2	Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
4	Abnormal (mutated), NOS
7	Test ordered, results not in chart
8	Not applicable: Information not collected for this case If this information is required by your standard setter, use of code 8 may result in an edit error.)
9	Not documented in medical record BRAF not assessed or unknown if assessed
Blank	Diagnosis year is prior to 2021