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    Item #
    Length
    Source of Standard
    Year Implemented
    Version Implemented
    Year Retired
    Version Retired
  
  
    3940
    1
    NAACCR
    2021
    21
    
    
  



NAACCR XML: Tumor.brafMutationalAnalysis



Description

The BRAF oncoprotein is involved in transmitting cell growth and proliferation signals from KRAS and NRAS. The BRAF V600E mutation is associated with poorer prognosis and predicts lack of response to anti-EGFR therapies.



Rationale

BRAF mutational analysis is recommended in clinical guidelines for patients with advanced colorectal cancer as a prognostic marker and factor in determining appropriate therapy.  It is a new data item for cases diagnosed 1/1/2021+.





Codes

        0 Normal  
 BRAF negative, BRAF wild type  
 Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
        1 Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
        2 Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
        3 Abnormal (mutated)/detected, KIAA1549: BRAF gene fusion
        4 Abnormal (mutated), NOS
        7 Test ordered, results not in chart
        8 Not applicable: Information not collected for this case  
If this information is required by your standard setter, use of code 8 may result in an edit error.)
        9 Not documented in medical record  
BRAF not assessed or unknown if assessed
        Blank Diagnosis year is prior to 2021



Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.

0	Normal BRAF negative, BRAF wild type Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected
1	Abnormal (mutated)/detected: BRAF V600E (c.1799T>A) mutation
2	Abnormal (mutated)/detected, but not BRAF V600E (c.1799T>A) mutation
3	Abnormal (mutated)/detected, KIAA1549: BRAF gene fusion
4	Abnormal (mutated), NOS
7	Test ordered, results not in chart
8	Not applicable: Information not collected for this case If this information is required by your standard setter, use of code 8 may result in an edit error.)
9	Not documented in medical record BRAF not assessed or unknown if assessed
Blank	Diagnosis year is prior to 2021