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{
"id" : "her2_ish_dual_probe_ration_4635",
"algorithm" : "eod_public",
"version" : "1.0",
"name" : "HER2 ISH DP Ratio",
"title" : "HER2 ISH Dual Probe Ratio",
"notes" : "**Note 1:** Physician statement of HER2 in situ hybridization (ISH) Dual Probe Ratio can be used to code this data item.\n\n**Note 2:** A dual probe test will report results for both HER2 and CEP17, the latter used as a control. The HER2/CEP17 ratio will be reported. Record the ratio in this data item. \n\n* ***Example:*** \n\n SISH RESULTS: FINAL HER 2 IN SITU HYBRIDIZATION INTERPRETATION: EQUIVOCAL, INDETERMINATE. HER2 gene copy between 4 & 6 with HER2/CEP17 ratio <2. \n \n HER2/CEP17 RATIO: 4.26 / 3.13 = 1.36\n \n HER-2/neu SILVER IN SITU HYBRIDIZATION (SISH) \n HER-2neu gene (Inform HER2 DNA probe) \n Number of tumor cell nuclei counted: 120 \n Number of Her-2/neu gene copies: 511\n Mean HER-2/neu gene copy number: 4.26\n \n CEP-17 SILVER IN SITU HYBRIDIZATION (SISH) \n CEP-17 (Inform Chromosome 17 probe) \n Number of cell nuclei counted: 60\n Number of CEP-17 gene copies: 188\n Mean CEP-17 gene copies/nucl: 3.13\n Code Dual Probe HER2 Copy Number: 4.2\n\n Code Dual Probe Ratio: 1.3\n\n**Note 3:** **Registrars are not to calculate the ratio.**\n\n**Note 4:** Following ASCO-CAP guidelines, a 2+ (equivocal) finding by immunohistochemistry (IHC) should result in additional testing with ISH to determine gene copy number. \n\n**Note 5:** Any type of ISH test (e.g., FISH, CISH, SISH) can be used to code this data item. The same test should be used to code all the HER2 ISH data items.\n\n**Note 6:** A HER2 ISH test may be called “ERBB2.” ERBB2 is the standard symbol for the gene ‘erb-b2 receptor tyrosine kinase 2.’ An IHC test identifies the protein expressed by the gene, and an ISH test identifies the gene itself.\n\n**Note 7:** If the test results are presented to the hundredth decimal, ignore the hundredth decimal. Do NOT round.\n\n* ***Example:*** \n Reported as 1.99, code as 1.9",
"last_modified" : "2018-03-12T16:39:56.721Z",
"definition" : [ {
"key" : "her2_ish_dp_ratio",
"name" : "Code",
"type" : "INPUT"
}, {
"key" : "description",
"name" : "Description",
"type" : "DESCRIPTION"
} ],
"rows" : [ [ "0.0-99.9", "Ratio of 0.0 to 99.9 " ], [ "XX.2", "Less than 2.0" ], [ "XX.3", "Greater than or equal to 2.0" ], [ "XX.7", "Test ordered, results not in chart" ], [ "XX.8", "Not applicable: Information not collected for this case\n(If this item is required by your standard setter, use of code XX.8 will result in an edit error.)" ], [ "XX.9", "Not documented in patient record\nResults cannot be determined (indeterminate)\nHER2 ISH dual probe ratio not assessed or unknown if assessed" ] ]
}