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{
"id" : "p16_hpv_human_papilloma_virus_status_head_and_neck_509",
"algorithm" : "eod_public",
"version" : "1.0",
"name" : "Human Papilloma Virus (HPV) Status",
"title" : "Human Papilloma Virus (HPV) Status",
"notes" : "**Note 1:** There is evidence that human papilloma virus (HPV) plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site.\n\n**Note 2:** Record the results of any HPV testing performed on pathological specimens including surgical and cytological (from cell blocks) tissue from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology.\n\n**Note 3:** There are several methods for determination of HPV status. The most frequently used test is IHC for p16 expression which is surrogate marker for HPV infection. **Do not record the results of IHC p16 expression in this field.** The rest of the tests (based on ISH, PCR, RT-PCR technologies) detect the viral DNA or RNA. **This data item is only for HPV status determined by tests designed to detect viral DNA or RNA.**\n\n**Note 4:** HPV-type 16 refers to virus type and is different from p16 overexpression (p16+).\n\n**Note 5:** Codes 0-7 are hierarchical; use the highest code that applies.",
"last_modified" : "2018-03-12T16:39:57.462Z",
"definition" : [ {
"key" : "seer_ssf1",
"name" : "Code",
"type" : "INPUT"
}, {
"key" : "description",
"name" : "Description",
"type" : "DESCRIPTION"
} ],
"rows" : [ [ "0", "HPV negative for viral DNA by ISH test" ], [ "1", "HPV positive for viral DNA by ISH test" ], [ "2", "HPV negative for viral DNA by PCR test" ], [ "3", "HPV positive for viral DNA by PCR test" ], [ "4", "HPV negative by ISH E6/E7 RNA test" ], [ "5", "HPV positive by ISH E6/E7 RNA test" ], [ "6", "HPV negative by RT-PCR E6/E7 RNA test" ], [ "7", "HPV positive by RT-PCR E6/E7 RNA test" ], [ "8", "HPV status reported in medical records as positive or negative but test type is unknown" ], [ "9", "Unknown if HPV test detecting viral DNA and or RNA was performed" ] ]
}