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{
  "id" : "oropharynx_hpv_mediated_p16_pos",
  "algorithm" : "eod_public",
  "version" : "1.1",
  "name" : "Oropharynx HPV-Mediated (p16+)",
  "title" : "Oropharynx HPV-Mediated (p16+)  (excluding Malignant Melanoma)",
  "notes" : "C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109 and Schema Discriminator 2: Oropharyngeal p16: 2 (8000-8700, 9700-9701)\n\nC111 and Schema Discriminator 1: Nasopharynx/PharyngealTonsil: 2 AND Schema Discriminator 2: Oropharyngeal p16: 2 (8000-8700, 9700-9701) \n\nC019 Base of tongue, NOS\nC024 Lingual tonsil\nC051 Soft palate, NOS\nC052 Uvula\nC090 Tonsillar fossa \nC091 Tonsillar pillar \nC098 Overlapping lesion of tonsil \nC099 Tonsil, NOS \nC100 Vallecula\nC102 Lateral wall of oropharynx\nC103 Posterior wall of oropharynx\nC104 Branchial cleft (site of neoplasm)\nC108 Overlapping lesion of oropharynx\nC109 Oropharynx, NOS\nC111 Pharyngeal tonsil\n\n**Note 1:** The following sources were used in the development of this schema\n* SEER Extent of Disease 1988: Codes and Coding Instructions (3rd Edition, 1998) (https://seer.cancer.gov/archive/manuals/EOD10Dig.3rd.pdf)\n* SEER Summary Staging Manual-2000: Codes and Coding Instructions (https://seer.cancer.gov/tools/ssm/)\n* Collaborative Stage Data Collection System, version 02.05:  https://cancerstaging.org/cstage/Pages/default.aspx \n* Chapter 10 *HPV-Mediated (p16+) Oropharyngeal Cancer*, in the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Used with permission of the American College of Surgeons, Chicago, Illinois.\n\n**Note 2:** See the following schemas for the listed histologies \n* C019, C024, C051-C052, C090-C091, C098-C099, C100, C102-C104, C108-C109 and Schema Discriminator 2: Oropharyngeal p16: 1, 9 (8000-8700, 9700-9701): *Oropharynx (p16-)*\n* C111 and Schema Discriminator 1: Nasopharynx/PharyngealTonsil:1  (8000-8700, 9700-9701): *Nasopharynx*\n* 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9110, 9121-9137, 9141-9230, 9240-9580, 9582: *Soft Tissue Head and Neck*\n* 8720-8790: *Melanoma Head and Neck*\n* 8804-8806, 8910, 8920, 8930-8931, 8991, 9020, 9044, 9120, 9231, 9581: *Soft Tissue Other*\n* 8935-8936: *GIST*\n* 9140: *Kaposi Sarcoma*\n\n**Note 3:** p16 immunotesting is mandatory to use this staging system for HPV-associated cancer. HPV by in situ hybridization (ISH) may be done as an alternative. If a case of oropharyngeal cancer has p16+, then this chapter is used. If a case does not have p16 or HPV by ISH, then the case is staged by the p16- system.",
  "schema_selection_table" : "schema_selection_oropharynx",
  "schema_discriminators" : [ "discriminator_1", "discriminator_2" ],
  "inputs" : [ {
    "key" : "year_dx",
    "name" : "Year of Diagnosis",
    "naaccr_item" : 390,
    "table" : "year_dx_validation",
    "used_for_staging" : false
  }, {
    "key" : "site",
    "name" : "Primary Site",
    "naaccr_item" : 400,
    "table" : "primary_site",
    "used_for_staging" : true
  }, {
    "key" : "hist",
    "name" : "Histology",
    "naaccr_item" : 522,
    "table" : "histology",
    "used_for_staging" : true
  }, {
    "key" : "behavior",
    "name" : "Behavior",
    "naaccr_item" : 523,
    "table" : "behavior",
    "used_for_staging" : true
  }, {
    "key" : "discriminator_1",
    "name" : "Schema Discriminator 1",
    "naaccr_item" : 3926,
    "table" : "nasopharynx_pharyngealtonsil_84756",
    "used_for_staging" : true,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "discriminator_2",
    "name" : "Schema Discriminator 2",
    "naaccr_item" : 3927,
    "default" : "9",
    "table" : "oropharyngeal_p16_44685",
    "used_for_staging" : true,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "size_clin",
    "name" : "Tumor Size Clinical",
    "naaccr_item" : 752,
    "table" : "tumor_size_clinical_60979",
    "used_for_staging" : false
  }, {
    "key" : "size_path",
    "name" : "Tumor Size Pathological",
    "naaccr_item" : 754,
    "table" : "tumor_size_pathological_25597",
    "used_for_staging" : false
  }, {
    "key" : "size_summary",
    "name" : "Tumor Size Summary",
    "naaccr_item" : 756,
    "default" : "999",
    "table" : "tumor_size_summary_63115",
    "used_for_staging" : true
  }, {
    "key" : "nodes_pos",
    "name" : "Regional Nodes Positive",
    "naaccr_item" : 820,
    "default" : "99",
    "table" : "nodes_pos_fpa",
    "used_for_staging" : true
  }, {
    "key" : "nodes_exam",
    "name" : "Regional Nodes Examined",
    "naaccr_item" : 830,
    "default" : "99",
    "table" : "nodes_exam_76029",
    "used_for_staging" : false
  }, {
    "key" : "radiation_surg_seq",
    "name" : "RX Summ Surgery/Radiation Sequence",
    "naaccr_item" : 1380,
    "table" : "radiation_surg_seq",
    "used_for_staging" : false
  }, {
    "key" : "systemic_surg_seq",
    "name" : "RX Summ Systemic/Surgery Sequence",
    "naaccr_item" : 1639,
    "table" : "systemic_surg_seq",
    "used_for_staging" : false
  }, {
    "key" : "eod_primary_tumor",
    "name" : "EOD Primary Tumor",
    "naaccr_item" : 772,
    "default" : "999",
    "table" : "extension_bap",
    "used_for_staging" : true
  }, {
    "key" : "eod_regional_nodes",
    "name" : "EOD Regional Nodes",
    "naaccr_item" : 774,
    "default" : "999",
    "table" : "nodes_dcu",
    "used_for_staging" : true
  }, {
    "key" : "eod_mets",
    "name" : "EOD Mets",
    "naaccr_item" : 776,
    "default" : "00",
    "table" : "eod_mets_80017",
    "used_for_staging" : true
  }, {
    "key" : "ss2018",
    "name" : "SS2018",
    "naaccr_item" : 764,
    "table" : "ss2018_oropharynx_excluding_melanoma_8720_8790_9999",
    "used_for_staging" : false
  }, {
    "key" : "grade_clin",
    "name" : "Grade Clinical",
    "naaccr_item" : 3843,
    "default" : "9",
    "table" : "grade_clinical_standard_94331",
    "used_for_staging" : false,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "grade_path",
    "name" : "Grade Pathological",
    "naaccr_item" : 3844,
    "default" : "9",
    "table" : "grade_pathological_standard_94268",
    "used_for_staging" : false,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "grade_post_therapy",
    "name" : "Grade Post Therapy",
    "naaccr_item" : 3845,
    "table" : "grade_post_therapy_standard_88293",
    "used_for_staging" : false,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "extranodal_ext_hn_clin",
    "name" : "Extranodal Exten H&N Clin",
    "naaccr_item" : 3831,
    "default" : "8",
    "table" : "extranodal_extension_head_and_neck_clinical_51375",
    "used_for_staging" : false,
    "metadata" : [ "COC_REQUIRED", "SSDI", "SEER_REQUIRED" ]
  }, {
    "key" : "extranodal_ext_hn_path",
    "name" : "Extranodal Exten H&N Path",
    "naaccr_item" : 3832,
    "default" : "X.8",
    "table" : "extranodal_extension_head_and_neck_pathological_93423",
    "used_for_staging" : false,
    "metadata" : [ "COC_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "ln_size_of_mets",
    "name" : "Lymph Nodes Size of Mets",
    "naaccr_item" : 3883,
    "default" : "XX.8",
    "table" : "lymph_nodes_size_of_metastasis_87329",
    "used_for_staging" : true,
    "metadata" : [ "COC_REQUIRED", "NPCR_REQUIRED", "SSDI", "CCCR_REQUIRED", "SEER_REQUIRED" ]
  }, {
    "key" : "seer_ssf1",
    "name" : "SEER Site-Specific Fact 1",
    "naaccr_item" : 3700,
    "default" : "9",
    "table" : "p16_hpv_human_papilloma_virus_status_head_and_neck_509",
    "used_for_staging" : false,
    "metadata" : [ "SSDI", "SEER_REQUIRED" ]
  } ],
  "outputs" : [ {
    "key" : "naaccr_schema_id",
    "name" : "Schema ID",
    "naaccr_item" : 3800,
    "default" : "00100"
  }, {
    "key" : "ajcc_id",
    "name" : "AJCC ID",
    "naaccr_item" : 995,
    "default" : "XX"
  }, {
    "key" : "derived_version",
    "name" : "Derived Version",
    "default" : "{{ctx_alg_version}}"
  }, {
    "key" : "eod_2018_t",
    "name" : "Derived EOD 2018 T",
    "naaccr_item" : 785,
    "default" : "88"
  }, {
    "key" : "eod_2018_n",
    "name" : "Derived EOD 2018 N",
    "naaccr_item" : 815,
    "default" : "88"
  }, {
    "key" : "eod_2018_m",
    "name" : "Derived EOD 2018 M",
    "naaccr_item" : 795,
    "default" : "88"
  }, {
    "key" : "eod_2018_stage_group",
    "name" : "Derived EOD 2018 Stage Group",
    "naaccr_item" : 818,
    "default" : "88"
  }, {
    "key" : "ss2018_derived",
    "name" : "Derived Summary Stage 2018",
    "naaccr_item" : 762,
    "default" : "9"
  } ],
  "mappings" : [ {
    "id" : "ajcc_chapter_calculation",
    "name" : "AJCC Chapter Calculation",
    "tables" : [ {
      "id" : "ajcc_chapter_calculation_46201",
      "inputs" : [ "site", "hist", "behavior" ],
      "outputs" : [ "ajcc_id" ]
    } ]
  }, {
    "id" : "summary_stage_2018",
    "name" : "Summary Stage 2018",
    "initial_context" : [ {
      "key" : "eod_2018_t",
      "value" : "90"
    }, {
      "key" : "eod_2018_n",
      "value" : "90"
    }, {
      "key" : "eod_2018_m",
      "value" : "90"
    } ],
    "tables" : [ {
      "id" : "extension_bap",
      "inputs" : [ "size_summary", "eod_primary_tumor" ],
      "outputs" : [ "eod_2018_t", "ss2018_t" ]
    }, {
      "id" : "nodes_dcu",
      "inputs" : [ "nodes_pos", "ln_size_of_mets", "eod_regional_nodes" ],
      "outputs" : [ "eod_2018_n", "ss2018_n", "stage_table_for_n" ]
    }, {
      "id" : "eod_mets_80017",
      "inputs" : [ "eod_mets" ],
      "outputs" : [ "eod_2018_m", "ss2018_m" ]
    }, {
      "id" : "summary_stage_rpa",
      "inputs" : [ "ss2018_m", "ss2018_n", "ss2018_t" ],
      "outputs" : [ "ss2018_derived" ]
    } ]
  }, {
    "id" : "eod_2018_stage_group",
    "name" : "EOD 2018 Stage Group",
    "inclusion_tables" : [ {
      "id" : "tnm8_inclusions_75047",
      "inputs" : [ "ajcc_id" ]
    } ],
    "initial_context" : [ {
      "key" : "eod_2018_stage_group",
      "value" : "90"
    } ],
    "tables" : [ {
      "id" : "parse_t_2177",
      "input_mapping" : [ {
        "from" : "eod_2018_t",
        "to" : "t"
      } ],
      "output_mapping" : [ {
        "from" : "root_t",
        "to" : "tmp_eod_t"
      } ],
      "inputs" : [ "eod_2018_t" ],
      "outputs" : [ "t_prefix", "tmp_eod_t" ]
    }, {
      "id" : "parse_n_67182",
      "input_mapping" : [ {
        "from" : "eod_2018_n",
        "to" : "n"
      } ],
      "output_mapping" : [ {
        "from" : "root_n",
        "to" : "tmp_eod_n"
      } ],
      "inputs" : [ "eod_2018_n" ],
      "outputs" : [ "n_prefix", "tmp_eod_n" ]
    }, {
      "id" : "parse_m_47057",
      "input_mapping" : [ {
        "from" : "eod_2018_m",
        "to" : "m"
      } ],
      "output_mapping" : [ {
        "from" : "root_m",
        "to" : "tmp_eod_m"
      } ],
      "inputs" : [ "eod_2018_m" ],
      "outputs" : [ "m_prefix", "tmp_eod_m" ]
    }, {
      "id" : "tnm_8_combined_stage_group_for_eod_79877",
      "input_mapping" : [ {
        "from" : "tmp_eod_n",
        "to" : "n"
      }, {
        "from" : "tmp_eod_m",
        "to" : "m"
      }, {
        "from" : "tmp_eod_t",
        "to" : "t"
      }, {
        "from" : "stage_table_for_n",
        "to" : "prefix_n_in"
      } ],
      "output_mapping" : [ {
        "from" : "stage",
        "to" : "eod_2018_stage_group"
      } ],
      "inputs" : [ "stage_table_for_n", "tmp_eod_n", "tmp_eod_m", "tmp_eod_t" ],
      "outputs" : [ "eod_2018_stage_group" ]
    } ]
  }, {
    "id" : "eod_tnm_cleanup",
    "name" : "EOD TNM Cleanup",
    "exclusion_tables" : [ {
      "id" : "tnm8_inclusions_75047",
      "inputs" : [ "ajcc_id" ]
    } ],
    "tables" : [ {
      "id" : "eod_tnm_component_cleanup_58170",
      "inputs" : [ "ajcc_id" ],
      "outputs" : [ "eod_2018_n", "eod_2018_m", "eod_2018_t", "eod_2018_stage_group" ]
    } ]
  } ],
  "involved_tables" : [ "schema_selection_oropharynx", "radiation_surg_seq", "nasopharynx_pharyngealtonsil_84756", "extranodal_extension_head_and_neck_clinical_51375", "nodes_pos_fpa", "parse_t_2177", "oropharyngeal_p16_44685", "eod_mets_80017", "parse_n_67182", "extranodal_extension_head_and_neck_pathological_93423", "histology", "nodes_exam_76029", "rn_positive_with_regional_nodes_for_ajcc_n_65676", "lymph_nodes_size_of_metastasis_87329", "tumor_size_summary_63115", "behavior", "nodes_dcu", "grade_post_therapy_standard_88293", "tumor_size_with_primary_tumor_for_ajcc_t_58130", "grade_clinical_standard_94331", "extension_bap", "ss2018_oropharynx_excluding_melanoma_8720_8790_9999", "lymph_nodes_size_with_regional_nodes_for_ajcc_n_7161", "tnm8_inclusions_75047", "tumor_size_pathological_25597", "systemic_surg_seq", "tumor_size_clinical_60979", "parse_m_47057", "p16_hpv_human_papilloma_virus_status_head_and_neck_509", "primary_site", "ajcc_chapter_calculation_46201", "eod_tnm_component_cleanup_58170", "year_dx_validation", "grade_pathological_standard_94268", "summary_stage_rpa", "tnm_8_combined_stage_group_for_eod_79877" ],
  "on_invalid_input" : "CONTINUE",
  "last_modified" : "2018-04-19T21:52:52.657Z"
}




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