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file.newsgroup.med.58944 Maven / Gradle / Ivy

From: [email protected] (Jim Zisfein) 
Subject: Re: Post Polio Syndrome Information Needed Please !!!

DN> From: [email protected] (David Nye)
DN> Briefly, this is a condition in which patients who have significant
DN> residual weakness from childhood polio notice progression of the
DN> weakness as they get older.  One theory is that the remaining motor
DN> neurons have to work harder and so die sooner.

If this theory were true, the muscle biopsy would show group atrophy
(evidence of acute loss of enlarged motor units); it doesn't.
Instead, the biopsy shows scattered, angulated, atrophic fibers.
This is more consistent with load-shedding by chronically overworked
motor neurons - the neurons survive, at the expense of increasingly
denervated muscle.
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 . SLMR 2.1 . E-mail: [email protected] (Jim Zisfein)