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data.pos.treebank.11597317.tree Maven / Gradle / Ivy
( (X (NP (NML (NN BRCA2) (CC and) (JJ homologous)) (NN recombination))) )
( (X (NP (NN Abstract))) )
( (S (NP-SBJ (CD Two) (JJ recent) (NNS papers)) (VP (VBP provide) (NP (NP (JJ new) (NN evidence)) (ADJP (JJ relevant) (PP (IN to) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NP (DT the) (NML (NN breast) (NN cancer) (NN susceptibility)) (NN gene)) (NP (NN BRCA2))))) (PP (IN in) (NP (NN DNA) (NN repair))))))) (. .)) )
( (S (NP-SBJ (NNP Moynahan) (FW et) (FW al)) (VP (VBP provide) (NP (NP (JJ genetic) (NNS data)) (VP (VBG indicating) (NP (NP (DT a) (NN requirement)) (PP (IN for) (NP (NP (NN BRCA2)) (PP (IN in) (NP (ADJP (ADJP (JJ homology) (HYPH -) (JJ dependent)) (-LRB- -LRB-) (ADJP (JJ recombinational))) (-RRB- -RRB-) (NN repair)) (PP (IN of) (NP (NN DNA) (ADJP (JJ double) (HYPH -) (JJ strand)) (NNS breaks)))))))))) (. .)) )
( (S (NP-SBJ-1 (NP (DT The) (JJ second) (NN paper)) (, ,) (PP (IN by) (NP (NNP Davies) (FW et) (FW al)))) (, ,) (VP (VBZ begins) (S (NP-SBJ-1 (-NONE- *PRO*)) (VP (TO to) (VP (VB address) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP-2 (IN through) (WHNP (WDT which))) (S (NP-SBJ (NN BRCA2)) (VP (VBZ makes) (NP (NP (PRP$ its) (NN contribution)) (PP (IN to) (NP (JJ recombinational) (NN repair)))) (PP-MNR-2 (-NONE- *T*)))))))))) (. .)) )
( (S (NP-SBJ-1 (NN BRCA2)) (VP (VBZ appears) (S (NP-SBJ-1 (-NONE- *PRO*)) (VP (TO to) (VP (VB function) (PP-MNR (IN in) (NP (NN recombination))) (PP-MNR (IN via) (NP (NP (NNS interactions)) (PP (IN with) (NP (DT the) (JJ major) (JJ eukaryotic) (NN recombinase) (NN RAD51)))))))) (PRN (-LRB- [) (NP (CD 1) (, ,) (CD 2) (, ,) (CD 3)) (-RRB- ]))) (. .)) )
( (S (S (NP-SBJ (PRP We)) (ADVP (RB briefly)) (VP (VBP review) (NP (NP (DT the) (NN context)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP-SBJ (DT the) (CD two) (NNS studies)) (VP (VBD were) (VP (VBN carried) (RP out) (NP (-NONE- *)) (PP-LOC (-NONE- *T*))))))))) (, ,) (S (NP-SBJ (PRP we)) (VP (VBP comment) (PP (IN on) (NP (DT the) (NNS results) (VBN presented))))) (, ,) (CC and) (S (NP-SBJ-1 (PRP we)) (VP (VBP discuss) (NP (NP (NNS models)) (VP (VBN designed) (NP (-NONE- *)) (S-PRP (NP-SBJ-1 (-NONE- *PRO*)) (VP (TO to) (VP (VB account) (PP (IN for) (NP (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN BRCA2)))) (PP (IN in) (NP (ADJP (JJ_SPLIT RAD51) (JJ_SPLIT –) (JJ_SPLIT mediated)) (NN repair)))))))))))) (. .)) )
( (X (NP (NP (NNS Keywords)) (: :) (NP (NP (NN breast) (NN cancer)) (, ,) (NP (JJ homologous) (NN recombination))))) )
( (X (NP (NN BRCA2))) )
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( (S (NP-SBJ (NP (NNS Cells)) (PP (IN with) (NP (JJ mutant) (NN BRCA2) (NN protein)))) (VP (VP (VBP are) (, ,) (PP (IN like) (NP (JJ many) (NN cancer) (NNS cells))) (, ,) (ADJP-PRD (RB genetically) (JJ unstable))) (CC and) (VP (VBP accumulate) (NP (JJ gross) (JJ chromosomal) (NNS rearrangements))) (PRN (-LRB- [) (NP (CD 5) (, ,) (CD 6)) (-RRB- ]))) (. .)) )
( (S (NP-SBJ (NP (NP (DT The) (NN sequence)) (PP (IN of) (NP (DT this) (JJ large) (NN protein)))) (-LRB- -LRB-) (NP (CD 3418) (JJ amino) (NNS acids))) (-RRB- -RRB-) (VP (VBZ offers) (NP (NP (RB very) (JJ little) (NN clue)) (PP (IN to) (NP (PRP$ its) (NN function)))) (, ,) (SBAR-ADV (IN although) (S (NP-SBJ (EX there)) (VP (VBP are) (NP-PRD (CD eight) (JJ repeated) (NNS segments) (PRN (-LRB- -LRB-) (S (NP-SBJ (-NONE- *PRO*)) (VP (VBN termed) (S (NP-SBJ (-NONE- *)) (NP-PRD (NN BRC) (NNS repeats))))) (-RRB- -RRB-))) (PP-LOC (IN in) (NP (NP (DT the) (NN middle)) (PP (IN of) (NP (NP (DT the) (NN protein)) (SBAR (WHNP-1 (WDT that)) (S (NP-SBJ-1 (-NONE- *T*)) (VP (VBP are) (ADJP-PRD (ADJP (RB highly) (VBN conserved)) (PP (IN among) (NP (JJ mammalian) (NNS orthologs)))))))))))) (PRN (-LRB- [) (NP (CD 7) (, ,) (CD 8)) (-RRB- ]))))) (. .)) )
( (X (NP (NP (NML (NN Breast) (NN cancer) (NN susceptibility)) (NNS genes)) (CC and) (NP (NN DNA) (NN repair)))) )
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( (S (NP-SBJ (NN BRCA1) (CC and) (NN BRCA2)) (VP (NN form) (NP (JJ discrete) (JJ nuclear) (NNS foci)) (PP-TMP (PP (IN during) (NP (NP (DT the) (NN S) (NN phase)))) (CC and) (PP (IN after) (NP (NP (NN exposure)) (PP (IN to) (NP (NML (NN DNA) (NN damaging)) (NNS agents)))))) (PRN (-LRB- [) (NP (CD 9) (, ,) (CD 10) (, ,) (CD 11)) (-RRB- ]))) (. .)) )
( (S (NP-SBJ (DT These) (NNS foci)) (VP (VBP are) (ADVP (RB probably)) (NP-SBJ (NP (NNS sites)) (PP (IN of) (NP (NP (NN repair)) (PP (IN of) (NP (ADJP (JJ spontaneous) (CC and) (VBN induced)) (NN DNA) (NN damage)))))) (PRN (-LRB- [) (NP (CD 12) (, ,) (CD 13) (, ,) (CD 14)) (-RRB- ]))) (. .)) )
( (S (NP-SBJ (NP (NN Cell) (NNS lines)) (ADJP (JJ defective) (PP (IN in) (NP (CC either) (NP (NN BRCA1) (CC or) (NN BRCA2)))))) (VP (VBP are) (ADJP-PRD (JJ sensitive) (PP (TO to) (NP (NP (NP (VBG damaging) (NNS agents)) (SBAR (WHNP-1 (WDT that)) (S (NP-SBJ-1 (-NONE- *T*)) (VP (VBP form) (NP (ADJP (JJ double) (HYPH -) (JJ strand)) (NNS breaks)))))) (-LRB- -LRB-) (NP (NNS DSBs)))))) (-RRB- -RRB-) (, ,) (PP (IN as) (VBP are) (JJ other) (NN cell) (NNS lines) (JJ defective) (IN in) (JJ recombinational) (NN repair) (-LRB- -LRB-) (VBN reviewed) (IN in) (-LRB- [) (CD 15) (-RRB- ]) (-RRB- -RRB-)) (. .)) )
( (S (NP-SBJ (NN BRCA2)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN RAD51) (NN recombinase))) (PP-MNR (IN via) (NP (JJ direct) (ADJP (JJ protein) (HYPH -) (JJ protein)) (NNS contacts))) (PRN (-LRB- [) (NP (CD 16) (, ,) (CD 17) (, ,) (CD 18) (, ,) (CD 19)) (-RRB- ]))) (. .)) )
( (S (NP-SBJ (JJ Biochemical) (NN analysis)) (ADVP (RB also)) (VP (VBD showed) (NP (NN interaction) (PP (IN between) (NP (NN BRCA1) (CC and) (NN RAD51)))) (, ,) (SBAR-ADV (IN although) (S (NP-SBJ (DT these) (VBN detected) (NNS interactions)) (VP (MD may) (VP (VB have) (VP (VBN been) (ADJP-PRD (JJ indirect))))))) (PRN (-LRB- [) (NP (CD 9)) (-RRB- ]))) (. .)) )
( (S (NP-SBJ (NP (DT The) (NN BRC) (NNS repeats)) (PP (IN of) (NP (NN BRCA2)))) (VP (VBP are) (ADJP-PRD (JJ responsible) (PP (IN for) (NP (JJ direct) (NN RAD51) (NN interaction))))) (. .)) )
( (S (NP-SBJ-1 (NP (NNS Cells)) (VP (VBG lacking) (NP (NN BRCA1/2)))) (VP (VBP fail) (S (NP-SBJ-1 (-NONE- *PRO*)) (VP (TO to) (VP (VB form) (NP (NML (ADJP (JJ damage) (HYPH -) (JJ induced)) (JJ subnuclear) (NN RAD51)) (NNS foci)) (PP-MNR (IN with) (NP (JJ normal) (NN efficiency)))))) (, ,) (S-ADV (VP (VBG suggesting) (SBAR (IN that) (S (NP-SBJ (DT these) (NNS proteins)) (VP (VBP are) (VP (VBN required) (NP (-NONE- *)) (PP-PRP (IN for) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (NN recombinase) (NNS complexes)) (PP (IN at) (NP (NP (DT the) (NNS sites)) (PP (IN of) (NP (NN DNA) (NN damage))))))))))))))) (PRN (-LRB- [) (NP (CD 20) (, ,) (CD 21)) (-RRB- ]))) (. .)) )
( (S (ADVP (RB Finally)) (, ,) (NP-SBJ (NP (JJ genetic) (NNS measurements)) (PP (IN of) (NP (NN recombination) (NN frequency)))) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP-SBJ (NML (JJ Brca1)) (HYPH -) (JJ /) (HYPH -) (ADJP (JJ embryonic) (NN stem)) (-LRB- -LRB-) (NP (NN ES)) (-RRB- -RRB-) (NNS cells)) (VP (VBP are) (ADJP-PRP (JJ deficient) (PP (IN in) (NP (JJ recombinational) (NN DSB) (NN repair))))))) (PRN (-LRB- [) (NP (CD 22) (, ,) (CD 23)) (-RRB- ])))) (. .)) )
( (S (NP-SBJ (NP (NP (DT The) (NN similarity)) (PP (IN between) (NP (NP (NNS phenotypes)) (ADJP (VBN associated) (PP (IN with) (NP (NML (NN BRCA1) (CC and) (NN BRCA2)) (NN deficiency))))))) (, ,) (ADVP (RB together)) (PP (IN with) (NP (NP (NNS data)) (VP (VBG showing) (NP (NP (DT a) (JJ similar) (NN effect)) (PP (IN of) (NP (NP (NN DNA) (NN damage)) (PP (IN on) (NP (NP (NN distribution)) (PP (IN of) (NP (NP (NN BRCA1) (CC and) (NN BRCA2)) (PP (IN in) (NP (ADJP (JJ repair) (HYPH -) (JJ proficient)) (NNS cells)))))))))))))) (, ,) (VP (VBD led) (PP (IN to) (NP (DT the) (NN hypothesis)) (SBAR (IN that) (S (NP-SBJ (NP (NN BRCA2)) (, ,) (PP (IN like) (NP (NN BRCA1)))) (, ,) (VP (VBZ is) (ADJP-PRD (VBN required) (PP-PRP (IN for) (NP (JJ efficient) (JJ recombinational) (NN repair))))))))) (. .)) )
( (S (NP-SBJ (NP (DT The) (NN paper)) (PP (IN by) (NP (NNP Moynahan) (FW et) (FW al))) (PRN (-LRB- [) (NP (CD 24)) (-RRB- ]))) (VP (VBZ provides) (NP (NP (JJ important) (NN support)) (PP (IN for) (NP (DT this) (NN hypothesis))))) (. .)) )
( (X (S (NP-SBJ (-NONE- *PRO*)) (VP (VBG Measuring) (NP (ADJP (JJ DSB) (HYPH -) (JJ induced)) (NN recombination) (NN frequency)) (PP (IN in) (NP (ADJP (JJ BRCA2) (HYPH -) (JJ defective)) (NNS cells)))))) )
( (S (NP-SBJ (NNP Pierce) (FW et) (FW al)) (VP (VBP have) (VP (VBN designed) (NP (NP (NP (DT a) (NN set)) (PP (IN of) (NP (NN recombination) (NNS substrates)))) (PP (IN for) (S-NOM (NP-SBJ (-NONE- *PRO*)) (VP (VBG measuring) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NP (JJ homologous) (NN recombination)) (PP (FW in) (NP (FW vivo)))))))))) (PRN (-LRB- -LRB-) (NP (NN Fig.) (CD 1)) (-RRB- -RRB-)) (PRN (-LRB- [) (NP (CD 25)) (-RRB- ])))) (. .)) )
( (S (NP-SBJ (DT The) (NN DNA) (NN substrate)) (VP (VBZ contains) (NP (NP (NP (DT a) (NN pair)) (PP (IN of) (NP (VBN mutated) (NN GFP) (NNS genes))) (PRN (-LRB- -LRB-) (S (NP-SBJ (NN GFP)) (VP (VBZ encodes) (NP (DT the) (ADJP (RB easily) (VBN detected)) (ADJP (JJ green) (JJ fluorescent)) (NN protein)))) (-RRB- -RRB-))) (, ,) (SBAR (WHNP-1 (NP (CD one)) (PP (IN of) (WHNP (WDT which)))) (S (NP-SBJ-1 (-NONE- *T*)) (VP (VBZ contains) (NP (NP (DT a) (NN restriction) (NN site)) (PP (IN for) (NP (NP (NN I) (HYPH -) (NN SceI)) (, ,) (NP (NP (DT a) (NML (NN yeast) (NN intron) (VBD encoded)) (NN endonuclease)) (PP (IN with) (NP (DT an) (NML (CD 18) (NN base) (NN pair)) (NN recognition) (NN site)))))))))))) (. .)) )
( (S (NP-SBJ (NP (JJ Transient) (NN transfection)) (PP (IN of) (NP (DT an) (NML (NN I) (HYPH -) (NN SceI)) (NN expression) (NN vector)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (DT a) (NN DSB)))) (PP (IN in) (NP (NP (DT the) (JJ first) (VBN mutated) (NN copy)) (PP (IN of) (NP (NN GFP))))))) (. .)) )
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( (S (NP-SBJ (NP (DT The) (NN configuration)) (PP (IN of) (NP (DT the) (NN GFP) (NN construct)))) (VBZ is) (JJ such) (IN that) (JJ homology) (HYPH -) (JJ mediated) (NN repair) (RB often) (VBZ results) (IN in) (DT the) (NN formation) (IN of) (DT a) (JJ functional) (NN copy) (IN of) (NN GFP) (. .)) )
( (S (NP-SBJ (JJ Such) (NNS events)) (VP (MD can) (VP (VB be) (VP (VBN detected) (NP (-NONE- *)) (PP-MNR (IN by) (NP (NML (ADJP (JJ fluorescence) (HYPH -) (JJ activated)) (NN cell) (NN sorting)) (NN analysis)) (PP-MNR (IN by) (NP (NP (NN virtue)) (PP (IN of) (NP (NP (PRP$ their) (NN expression)) (PP (IN of) (NP (NN GFP))))))))))) (. .)) )
( (S (NP-SBJ (NNP Moynahan) (FW et) (FW al) (PRN (-LRB- [) (NP (CD 24)) (-RRB- ]))) (VP (VBP have) (VP (VBN used) (NP (PDT such) (DT a) (NML (NN GFP) (NN recombination)) (NN substrate)) (S-PRP (NP-SBJ (-NONE- *PRO*)) (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP-SBJ (NP (NNS cells)) (PP (IN with) (NP (JJ defective) (NN BRCA2) (NN protein)))) (VP (VBP are) (ADJP-PRD (JJ deficient) (PP (IN in) (NP (NP (PRP$ their) (NN ability)) (S (NP-SBJ (-NONE- *PRO*)) (VP (TO to) (VP (VB repair) (NP (DT the) (ADJP (NML (JJ I) (HYPH -) (JJ SceI)) (HYPH -) (JJ induced)) (NN DSB)) (PP-MNR (IN through) (NP (JJ homologous) (NN recombination))))))))))))))))) (. .)) )
( (S (NP-SBJ (NP (NN Expression)) (PP (IN of) (NP (NN I) (HYPH -) (NN SceI)))) (VP (VBD resulted) (PP (IN in) (S (NP-SBJ (QP (CD 1) (IN out) (IN of) (CD 1400)) (NNS cells)) (VP (VBG producing) (NP (NN GFP)) (PP-MNR (IN via) (NP (NP (JJ homologous) (NN recombination)) (PP (IN in) (NP (NP (DT the) (NML (JJ human) (NML (JJ pancreatic) (NN tumor)) (NN cell)) (NN line)) (NP (NN CAPAN) (HYPH -) (NN 1)))))))))) (. .)) )
( (S (NP-SBJ (NML (NN CAPAN) (HYPH -) (NN 1)) (NNS cells)) (VP (VP (VBP carry) (NP (DT a) (NP (NN deletion)) (PP (IN of) (NP (NN BRCA2)))) (PP (IN on) (NP (CD one) (NN homolog)))) (CC and) (VP (NNS codes) (PP (IN for) (NP (NP (DT a) (NN protein)) (VP (VBN truncated) (PP (IN at) (NP (JJ amino) (NN acid) (CD 1981)))))) (PP (IN on) (NP (DT the) (JJ other) (NN homolog)))))) (. .) )
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( (X (NP (NNS Abbreviations))) )
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