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/*-
*
* Copyright 2018, 2020 The Jackson Laboratory Inc.
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*
* @author Matthew Gerring
*/
package org.geneweaver.domain;
import java.util.Arrays;
import java.util.Objects;
import javax.annotation.processing.Generated;
import org.neo4j.ogm.annotation.Index;
import org.neo4j.ogm.annotation.NodeEntity;
import com.fasterxml.jackson.annotation.JsonIgnore;
import com.fasterxml.jackson.annotation.JsonInclude;
/**
*
* A Genomic Region, usually from a bed file.
*
* Required fields
The first three fields in each feature line are required:
chr - name of the chromosome or scaffold. Any valid seq_region_name can be used, and chromosome names can be given with or without the 'chr' prefix.
chromStart - Start position of the feature in standard chromosomal coordinates (i.e. first base is 0).
chromEnd - End position of the feature in standard chromosomal coordinates
chr1 213941196 213942363
chr1 213942363 213943530
chr1 213943530 213944697
chr2 158364697 158365864
chr2 158365864 158367031
chr3 127477031 127478198
chr3 127478198 127479365
chr3 127479365 127480532
chr3 127480532 127481699
Optional fields
Nine additional fields are optional. Note that columns cannot be empty - lower-numbered fields must always be populated if higher-numbered ones are used.
name - Label to be displayed under the feature, if turned on in "Configure this page".
score - A score between 0 and 1000. See track lines, below, for ways to configure the display style of scored data.
strand - defined as + (forward) or - (reverse).
thickStart - coordinate at which to start drawing the feature as a solid rectangle
thickEnd - coordinate at which to stop drawing the feature as a solid rectangle
itemRgb - an RGB colour value (e.g. 0,0,255). Only used if there is a track line with the value of itemRgb set to "on" (case-insensitive).
blockCount - the number of sub-elements (e.g. exons) within the feature
blockSizes - the size of these sub-elements
blockStarts - the start coordinate of each sub-element
chr7 127471196 127472363 Pos1 0 + 127471196 127472363 255,0,0
chr7 127472363 127473530 Pos2 0 + 127472363 127473530 255,0,0
chr7 127473530 127474697 Pos3 0 + 127473530 127474697 255,0,0
chr7 127474697 127475864 Pos4 0 + 127474697 127475864 255,0,0
chr7 127475864 127477031 Neg1 0 - 127475864 127477031 0,0,255
chr7 127477031 127478198 Neg2 0 - 127477031 127478198 0,0,255
chr7 127478198 127479365 Neg3 0 - 127478198 127479365 0,0,255
chr7 127479365 127480532 Pos5 0 + 127479365 127480532 255,0,0
chr7 127480532 127481699 Neg4 0 - 127480532 127481699 0,0,255
chr
start
end
name
score
strand
thickStart
thickEnd
itemRgb
blockCount
blockSizes
blockStarts
* @author gerrim
*
*/
@Generated("POJO")
@NodeEntity(label="Peak")
public class Peak extends NamedEntity implements Located {
@Index(unique=true)
@JsonInclude(JsonInclude.Include.NON_NULL)
private String peakId;
/**
* The epigenome code from ensembl
* E.g. A673/ sigmoid_colon/ etc. corresponding to the directory name in the source data.
* This property is called 'epigenome' in the gff format.
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private String epigenome;
/**
* The epigenome description from ensembl
* E.g. @see http://useast.ensembl.org/Homo_sapiens/Experiment/Sources?db=core;ex=all and
* @see http://useast.ensembl.org/Mus_musculus/Experiment/Sources?db=core;ex=all
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private String tissueDescription;
/**
* The epigenome description from ensembl, usually something like "Cell/Tissue"
* E.g. @see http://useast.ensembl.org/Homo_sapiens/Experiment/Sources?db=core;ex=all and
* @see http://useast.ensembl.org/Mus_musculus/Experiment/Sources?db=core;ex=all
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private String filterType;
/**
* The subdir of the new data sources e.g. H3K4me1
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private String featureType;
/**
* Start position of the feature in standard chromosomal coordinates (i.e. first base is 0).
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private Integer start;
/**
* End position of the feature in standard chromosomal coordinates.
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private Integer end;
/**
* A score between 0 and 1000. See track lines, below, for ways to configure the display style of scored data.
*/
@JsonInclude(JsonInclude.Include.NON_NULL)
private int score;
/**
* defined as + (forward) or - (reverse).
*/
private Strand strand;
/**
* coordinate at which to start drawing the feature as a solid rectangle
*/
private int thickStart;
/**
* coordinate at which to stop drawing the feature as a solid rectangle
*/
private int thickEnd;
/**
* an RGB colour value (e.g. 0,0,255). Only used if there is a track line with the value of itemRgb set to "on" (case-insensitive).
*/
private int[] itemRgb;
/**
* the number of sub-elements (e.g. exons) within the feature
*/
private int blockCount;
/**
* the size of these sub-elements
*/
private int[] blockSizes;
/**
* the size of these sub-elements
*/
private int[] blockStarts;
public enum Strand {
FORWARD, REVERSE;
public static Strand from(String seg) {
if ("+".equals(seg)) return FORWARD;
if ("-".equals(seg)) return REVERSE;
return null; // They can choose to put null/none etc.
}
public String toString() {
if (this==FORWARD) return "+";
if (this==REVERSE) return "-";
return null;
}
}
public Peak() {
}
public Peak(String name) {
this.setName(name);
}
public Peak(String peakId, String species, String chr, int start, int end, String name, int score, Strand strand, int thickStart, int thickEnd) {
this.peakId = peakId;
setSpecies(species);
setChr(chr);
this.start = start;
this.end = end;
this.setName(name);
this.score = score;
this.strand = strand;
this.thickStart = thickStart;
this.thickEnd = thickEnd;
}
public Peak(String speakId, int low, int high) {
this.peakId = speakId;
this.start = low;
this.end = high;
}
/**
* Gets the header.
*
* @return the header
*/
@Override
public String getHeader() {
StringBuilder buf = new StringBuilder();
String fields = delimify("peakId:ID(Peak-Id)",
"epigenome", "tissueDescription", "featureType", "filterType",
"start:int", "end:int", "chr", "score:int", "strand", ":LABEL");
buf.append(fields);
String sheader = super.getHeader();
if (sheader!=null) {
buf.append(getDelimiter());
buf.append(sheader);
}
return buf.toString();
}
/**
* To csv.
*
* @return the string
*/
@Override
public String toCsv() {
StringBuilder buf = new StringBuilder();
String values = delimify(getPeakId(),
getEpigenome(), getTissueDescription(), getFeatureType(), getFilterType(),
getStart(), getEnd(), getChr(), getScore(), strandCharacter(getStrand()),
getClass().getSimpleName().toString());
buf.append(values);
String scsv = super.toCsv();
if (scsv!=null) {
buf.append(getDelimiter());
buf.append(scsv);
}
return buf.toString();
}
@JsonIgnore
private String strandCharacter(Strand s) {
if (s==null) return null;
return s.toString();
}
/**
* @return the start
*/
public Integer getStart() {
return start;
}
/**
* @param start the start to set
*/
public void setStart(Integer start) {
this.start = start;
}
/**
* @return the end
*/
public Integer getEnd() {
return end;
}
/**
* @param end the end to set
*/
public void setEnd(Integer end) {
this.end = end;
}
/**
* @return the score
*/
public int getScore() {
return score;
}
/**
* @param score the score to set
*/
public void setScore(int score) {
this.score = score;
}
/**
* @return the strand
*/
public Strand getStrand() {
return strand;
}
/**
* @param strand the strand to set
*/
public void setStrand(Strand strand) {
this.strand = strand;
}
/**
* @return the thickStart
*/
public int getThickStart() {
return thickStart;
}
/**
* @param thickStart the thickStart to set
*/
public void setThickStart(int thickStart) {
this.thickStart = thickStart;
}
/**
* @return the thickEnd
*/
public int getThickEnd() {
return thickEnd;
}
/**
* @param thickEnd the thickEnd to set
*/
public void setThickEnd(int thickEnd) {
this.thickEnd = thickEnd;
}
/**
* @return the itemRgb
*/
public int[] getItemRgb() {
return itemRgb;
}
/**
* @param itemRgb the itemRgb to set
*/
public void setItemRgb(int[] itemRgb) {
this.itemRgb = itemRgb;
}
/**
* @return the blockCount
*/
public int getBlockCount() {
return blockCount;
}
/**
* @param blockCount the blockCount to set
*/
public void setBlockCount(int blockCount) {
this.blockCount = blockCount;
}
/**
* @return the blockSizes
*/
public int[] getBlockSizes() {
return blockSizes;
}
/**
* @param blockSizes the blockSizes to set
*/
public void setBlockSizes(int... blockSizes) {
this.blockSizes = blockSizes;
}
/**
* @return the blockStarts
*/
public int[] getBlockStarts() {
return blockStarts;
}
/**
* @param blockStarts the blockStarts to set
*/
public void setBlockStarts(int... blockStarts) {
this.blockStarts = blockStarts;
}
@Override
public int hashCode() {
final int prime = 31;
int result = super.hashCode();
result = prime * result + Arrays.hashCode(blockSizes);
result = prime * result + Arrays.hashCode(blockStarts);
result = prime * result + Arrays.hashCode(itemRgb);
result = prime * result + Objects.hash(blockCount, end, epigenome, featureType, filterType, peakId, score,
start, strand, thickEnd, thickStart, tissueDescription);
return result;
}
@Override
public boolean equals(Object obj) {
if (this == obj)
return true;
if (!super.equals(obj))
return false;
if (!(obj instanceof Peak))
return false;
Peak other = (Peak) obj;
return blockCount == other.blockCount && Arrays.equals(blockSizes, other.blockSizes)
&& Arrays.equals(blockStarts, other.blockStarts) && Objects.equals(end, other.end)
&& Objects.equals(epigenome, other.epigenome) && Objects.equals(featureType, other.featureType)
&& Objects.equals(filterType, other.filterType) && Arrays.equals(itemRgb, other.itemRgb)
&& Objects.equals(peakId, other.peakId) && score == other.score && Objects.equals(start, other.start)
&& strand == other.strand && thickEnd == other.thickEnd && thickStart == other.thickStart
&& Objects.equals(tissueDescription, other.tissueDescription);
}
/**
* @return the peakId
*/
public String getPeakId() {
return peakId;
}
/**
* @param peakId the peakId to set
*/
public void setPeakId(String peakId) {
this.peakId = peakId;
}
/**
* @return the epigenome
*/
public String getEpigenome() {
return epigenome;
}
/**
* @param epigenome the epigenome to set
*/
public void setEpigenome(String epigenome) {
this.epigenome = epigenome;
}
/**
* @return the tissueDescription
*/
public String getTissueDescription() {
return tissueDescription;
}
/**
* @param tissueDescription the tissueDescription to set
*/
public void setTissueDescription(String tissueDescription) {
this.tissueDescription = tissueDescription;
}
/**
* @return the featureType
*/
public String getFeatureType() {
return featureType;
}
/**
* @param featureType the featureType to set
*/
public void setFeatureType(String featureType) {
this.featureType = featureType;
}
/**
* @return the filterType
*/
public String getFilterType() {
return filterType;
}
/**
* @param filterType the filterType to set
*/
public void setFilterType(String filterType) {
this.filterType = filterType;
}
@Override
public String id() {
return getPeakId();
}
}
