org.nmdp.ngs.variant.vcf.VcfWriter Maven / Gradle / Ivy
/*
ngs-variant Variants.
Copyright (c) 2014-2015 National Marrow Donor Program (NMDP)
This library is free software; you can redistribute it and/or modify it
under the terms of the GNU Lesser General Public License as published
by the Free Software Foundation; either version 3 of the License, or (at
your option) any later version.
This library is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; with out even the implied warranty of MERCHANTABILITY or
FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public
License for more details.
You should have received a copy of the GNU Lesser General Public License
along with this library; if not, write to the Free Software Foundation,
Inc., 59 Temple Place, Suite 330, Boston, MA 02111-1307 USA.
> http://www.gnu.org/licenses/lgpl.html
*/
package org.nmdp.ngs.variant.vcf;
import static com.google.common.base.Preconditions.checkNotNull;
import java.io.PrintWriter;
import java.util.ArrayList;
import java.util.List;
import com.google.common.base.Joiner;
/**
* VCF writer.
*/
public final class VcfWriter {
/**
* Private no-arg constructor.
*/
private VcfWriter() {
// empty
}
/**
* Write VCF with the specified print writer.
*
* @param header VCF header, must not be null
* @param samples zero or more VCF samples, must not be null
* @param records zero or more VCF records, must not be null
* @param writer print writer to write VCF with, must not be null
*/
public static void write(final VcfHeader header,
final List samples,
final List records,
final PrintWriter writer) {
writeHeader(header, writer);
writeColumnHeader(samples, writer);
writeRecords(samples, records, writer);
}
/**
* Write VCF header with the specified print writer.
*
* @param header VCF header, must not be null
* @param writer print writer to write VCF with, must not be null
*/
public static void writeHeader(final VcfHeader header, final PrintWriter writer) {
checkNotNull(header);
checkNotNull(writer);
for (String meta : header.getMeta()) {
writer.println(meta);
}
}
/**
* Write VCF column header with the specified print writer.
*
* @param samples zero or more VCF samples, must not be null
* @param writer print writer to write VCF with, must not be null
*/
public static void writeColumnHeader(final List samples, final PrintWriter writer) {
checkNotNull(samples);
checkNotNull(writer);
StringBuilder sb = new StringBuilder("#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO");
if (!samples.isEmpty()) {
sb.append("\tFORMAT");
}
for (VcfSample sample : samples) {
sb.append("\t");
sb.append(sample.getId());
}
writer.println(sb.toString());
}
/**
* Write VCF records with the specified print writer.
*
* @param samples zero or more VCF samples, must not be null
* @param records zero or more VCF records, must not be null
* @param writer print writer to write VCF with, must not be null
*/
public static void writeRecords(final List samples,
final List records,
final PrintWriter writer) {
checkNotNull(samples);
checkNotNull(records);
checkNotNull(writer);
for (VcfRecord record : records) {
writeRecord(samples, record, writer);
}
}
/**
* Write VCF record with the specified print writer.
*
* @param samples zero or more VCF samples, must not be null
* @param record VCF record, must not be null
* @param writer print writer to write VCF with, must not be null
*/
public static void writeRecord(final List samples, final VcfRecord record, final PrintWriter writer) {
checkNotNull(samples);
checkNotNull(record);
checkNotNull(writer);
StringBuilder sb = new StringBuilder();
sb.append(record.getChrom());
sb.append("\t");
sb.append(record.getPos());
sb.append("\t");
if (record.getId().length == 0) {
sb.append(".");
}
else {
sb.append(Joiner.on(";").join(record.getId()));
}
sb.append("\t");
sb.append(record.getRef());
sb.append("\t");
sb.append(Joiner.on(",").join(record.getAlt()));
sb.append("\t");
if (Double.isNaN(record.getQual())) {
sb.append(".");
}
else {
sb.append((int) record.getQual());
}
sb.append("\t");
sb.append(Joiner.on(";").join(record.getFilter()));
sb.append("\t");
if (record.getInfo().isEmpty()) {
sb.append(".");
}
else {
sb.append(Joiner.on(";").withKeyValueSeparator("=").join(record.getInfo().asMap()));
}
if (!samples.isEmpty()) {
sb.append("\t");
sb.append(Joiner.on(":").join(record.getFormat()));
for (VcfSample sample : samples) {
sb.append("\t");
List values = new ArrayList();
for (String formatId : record.getFormat()) {
List fieldValues = record.getGenotypes().get(sample.getId()).getFields().get(formatId);
values.add(fieldValues.isEmpty() ? "." : Joiner.on(",").join(fieldValues));
}
sb.append(Joiner.on(":").join(values));
}
}
writer.println(sb.toString());
}
}
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