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package org.broadinstitute.hellbender.utils;
import com.google.common.collect.AbstractIterator;
import com.google.common.collect.Iterators;
import com.google.common.primitives.Ints;
import htsjdk.samtools.SAMFileHeader;
import htsjdk.tribble.util.ParsingUtils;
import org.apache.commons.lang3.ArrayUtils;
import org.apache.commons.lang3.StringUtils;
import org.apache.commons.math3.random.RandomDataGenerator;
import org.apache.commons.math3.random.Well19937c;
import org.apache.logging.log4j.LogManager;
import org.apache.logging.log4j.Logger;
import org.broadinstitute.hellbender.exceptions.GATKException;
import org.broadinstitute.hellbender.utils.param.ParamUtils;
import javax.annotation.Nullable;
import java.io.*;
import java.lang.reflect.Array;
import java.math.BigInteger;
import java.nio.file.Files;
import java.nio.file.Path;
import java.security.MessageDigest;
import java.security.NoSuchAlgorithmException;
import java.time.ZonedDateTime;
import java.time.format.DateTimeFormatter;
import java.time.format.FormatStyle;
import java.util.*;
import java.util.concurrent.*;
import java.util.function.Function;
import java.util.function.IntFunction;
import java.util.function.Supplier;
import java.util.regex.Pattern;
import java.util.stream.Collectors;
import java.util.stream.Stream;
import java.util.stream.StreamSupport;
public final class Utils {
/**
* Comparator for strings that sorts null first;
*/
public static final Comparator COMPARE_STRINGS_NULLS_FIRST = Comparator.nullsFirst(Comparator.naturalOrder());
private Utils(){}
private final static DateTimeFormatter longDateTimeFormatter = DateTimeFormatter.ofLocalizedDateTime(FormatStyle.LONG);
/**
* Static random number generator and seed.
*/
private static final long GATK_RANDOM_SEED = 47382911L;
private static final Random randomGenerator = new Random(GATK_RANDOM_SEED);
private static final RandomDataGenerator randomDataGenerator = new RandomDataGenerator(new Well19937c(GATK_RANDOM_SEED));
public static Random getRandomGenerator() { return randomGenerator; }
public static RandomDataGenerator getRandomDataGenerator() { return randomDataGenerator; }
public static void resetRandomGenerator() {
randomGenerator.setSeed(GATK_RANDOM_SEED);
randomDataGenerator.reSeed(GATK_RANDOM_SEED);
}
private static final int TEXT_WARNING_WIDTH = 68;
private static final String TEXT_WARNING_PREFIX = "* ";
private static final String TEXT_WARNING_BORDER = StringUtils.repeat('*', TEXT_WARNING_PREFIX.length() + TEXT_WARNING_WIDTH);
private static final char ESCAPE_CHAR = '\u001B';
public static final float JAVA_DEFAULT_HASH_LOAD_FACTOR = 0.75f;
/** our log, which we want to capture anything from this class */
private static final Logger logger = LogManager.getLogger(Utils.class);
public static List cons(final T elt, final List l) {
final List l2 = new ArrayList<>();
l2.add(elt);
if (l != null) {
l2.addAll(l);
}
return l2;
}
public static void warnUser(final String msg) {
warnUser(logger, msg);
}
public static void warnUser(final Logger logger, final String msg) {
for (final String line: warnUserLines(msg)) {
logger.warn(line);
}
}
public static List warnUserLines(final String msg) {
final List results = new ArrayList<>();
results.add(TEXT_WARNING_BORDER);
results.add(TEXT_WARNING_PREFIX + "WARNING:");
results.add(TEXT_WARNING_PREFIX);
prettyPrintWarningMessage(results, msg);
results.add(TEXT_WARNING_BORDER);
return results;
}
/**
* pretty print the warning message supplied
*
* @param results the pretty printed message
* @param message the message
*/
private static void prettyPrintWarningMessage(final List results, final String message) {
for (final String line: message.split("\\r?\\n")) {
final StringBuilder builder = new StringBuilder(line);
while (builder.length() > TEXT_WARNING_WIDTH) {
int space = getLastSpace(builder, TEXT_WARNING_WIDTH);
if (space <= 0) {
space = TEXT_WARNING_WIDTH;
}
results.add(String.format("%s%s", TEXT_WARNING_PREFIX, builder.substring(0, space)));
builder.delete(0, space + 1);
}
results.add(String.format("%s%s", TEXT_WARNING_PREFIX, builder));
}
}
/**
* Returns the last whitespace location in string, before width characters.
* @param message The message to break.
* @param width The width of the line.
* @return The last whitespace location.
*/
private static int getLastSpace(final CharSequence message, final int width) {
final int length = message.length();
int stopPos = width;
int currPos = 0;
int lastSpace = -1;
boolean inEscape = false;
while (currPos < stopPos && currPos < length) {
final char c = message.charAt(currPos);
if (c == ESCAPE_CHAR) {
stopPos++;
inEscape = true;
} else if (inEscape) {
stopPos++;
if (Character.isLetter(c)) {
inEscape = false;
}
} else if (Character.isWhitespace(c)) {
lastSpace = currPos;
}
currPos++;
}
return lastSpace;
}
/**
* Returns a string of the values in an {@link Object} array joined by a separator.
*
* @param separator separator character
* @param objects the array with values
*
* @throws IllegalArgumentException if {@code separator} or {@code objects} is {@code null}.
* @return a string with the values separated by the separator
*/
public static String join(final CharSequence separator, final Object ... objects) {
Utils.nonNull(separator, "the separator cannot be null");
Utils.nonNull(objects, "the value array cannot be null");
if (objects.length == 0) {
return "";
} else {
final StringBuilder ret = new StringBuilder();
ret.append(objects[0]);
for (int i = 1; i < objects.length; i++) {
ret.append(separator).append(objects[i]);
}
return ret.toString();
}
}
/**
* Returns a string of the values in ints joined by separator, such as A,B,C
*
* @param separator separator character
* @param ints the array with values
* @return a string with the values separated by the separator
*/
public static String join(final String separator, final int[] ints) {
Utils.nonNull(separator, "the separator cannot be null");
Utils.nonNull(ints, "the ints cannot be null");
if ( ints.length == 0) {
return "";
} else {
final StringBuilder ret = new StringBuilder();
ret.append(ints[0]);
for (int i = 1; i < ints.length; ++i) {
ret.append(separator);
ret.append(ints[i]);
}
return ret.toString();
}
}
/**
* Returns a string of the values in joined by separator, such as A,B,C
*
* @param separator separator character
* @param doubles the array with values
* @return a string with the values separated by the separator
*/
public static String join(final String separator, final double[] doubles) {
Utils.nonNull(separator, "the separator cannot be null");
Utils.nonNull(doubles, "the doubles cannot be null");
if ( doubles.length == 0) {
return "";
} else {
final StringBuilder ret = new StringBuilder();
ret.append(doubles[0]);
for (int i = 1; i < doubles.length; ++i) {
ret.append(separator);
ret.append(doubles[i]);
}
return ret.toString();
}
}
/**
* Returns a string of the form elt1.toString() [sep elt2.toString() ... sep elt.toString()] for a collection of
* elti objects (note there's no actual space between sep and the elti elements). Returns
* "" if collection is empty. If collection contains just elt, then returns elt.toString()
*
* @param separator the string to use to separate objects
* @param objects a collection of objects. the element order is defined by the iterator over objects
* @param the type of the objects
* @return a non-null string
*/
public static String join(final String separator, final Collection objects) {
if (objects.isEmpty()) { // fast path for empty collection
return "";
} else {
final Iterator iter = objects.iterator();
final T first = iter.next();
if ( ! iter.hasNext() ) // fast path for singleton collections
{
return first.toString();
} else { // full path for 2+ collection that actually need a join
final StringBuilder ret = new StringBuilder(first.toString());
while(iter.hasNext()) {
ret.append(separator);
ret.append(iter.next().toString());
}
return ret.toString();
}
}
}
/**
* Concatenates byte arrays
* @return a concat of all bytes in allBytes in order
*/
public static byte[] concat(final byte[] ... allBytes) {
if (allBytes.length == 0) {
return ArrayUtils.EMPTY_BYTE_ARRAY;
} else if (allBytes.length == 1) {
return allBytes[0].length == 0 ? allBytes[0] : allBytes[0].clone();
} else {
int size = 0;
for (final byte[] bytes : allBytes) size += bytes.length;
if (size == 0) {
return ArrayUtils.EMPTY_BYTE_ARRAY;
} else {
final byte[] c = new byte[size];
int offset = 0;
for (final byte[] bytes : allBytes) {
System.arraycopy(bytes, 0, c, offset, bytes.length);
offset += bytes.length;
}
return c;
}
}
}
public static T[] concat(final T[] a, final T[] b, final IntFunction constructor) {
Utils.nonNull(a);
Utils.nonNull(b);
if (a.length != 0) {
if (b.length != 0) {
final T[] c = constructor.apply(a.length + b.length);
System.arraycopy(a, 0, c, 0, a.length);
System.arraycopy(b, 0, c, a.length, b.length);
return c;
} else {
return a.clone();
}
} else if (b.length != 0) {
return b.clone();
} else {
return a.clone();
}
}
/**
* Concats two byte arrays.
*
* A bit more efficient than calling the more general {@link #concat(byte[]...)}.
*
* @param a left array to concat.
* @param b right array to concat.
* @return never {@code null};
*/
public static byte[] concat(final byte[] a, final byte[] b) {
final int length = a.length + b.length;
if (length == 0) {
return ArrayUtils.EMPTY_BYTE_ARRAY;
} else if (length == a.length) {
return a.clone();
} else if (length == b.length) {
return b.clone();
} else {
final byte[] c = new byte[length];
int i = 0;
for (final byte aa : a) {
c[i++] = aa;
}
for (final byte bb : b) {
c[i++] = bb;
}
return c;
}
}
/**
* Returns a {@link List List<Integer>} representation of an primitive int array.
* @param values the primitive int array to represent.
* @return never code {@code null}. The returned list will be unmodifiable yet it will reflect changes in values in the original array yet
* you cannot change the values
*/
public static List asList(final int ... values) {
Utils.nonNull(values, "the input array cannot be null");
return new AbstractList() {
@Override
public Integer get(final int index) {
return values[index];
}
@Override
public int size() {
return values.length;
}
};
}
/**
* Returns a {@link List List<Double>} representation of an primitive double array.
* @param values the primitive int array to represent.
* @return never code {@code null}. The returned list will be unmodifiable yet it will reflect changes in values in the original array yet
* you cannot change the values.
*/
public static List asList(final double ... values) {
Utils.nonNull(values, "the input array cannot be null");
return new AbstractList() {
@Override
public Double get(final int index) {
return values[index];
}
@Override
public int size() {
return values.length;
}
};
}
/**
* Create a new list that contains the elements of left along with elements elts
* @param left a non-null list of elements
* @param elts a varargs vector for elts to append in order to left
* @return A newly allocated linked list containing left followed by elts
*/
@SafeVarargs
public static List append(final List left, final T ... elts) {
Utils.nonNull(left, "left is null");
Utils.nonNull(elts, "the input array cannot be null");
final List l = new LinkedList<>(left);
for (final T t : elts){
Utils.nonNull(t, "t is null");
l.add(t);
}
return l;
}
/**
* Create a new string that's n copies of c
* @param c the char to duplicate
* @param nCopies how many copies?
* @return a string
*/
public static String dupChar(final char c, final int nCopies) {
final char[] chars = new char[nCopies];
Arrays.fill(chars, c);
return new String(chars);
}
/**
* Create a new string thats a n duplicate copies of s
* @param s the string to duplicate
* @param nCopies how many copies?
* @return a string
*/
public static String dupString(final String s, int nCopies) {
if ( s == null || s.equals("") ) { throw new IllegalArgumentException("Bad s " + s); }
if ( nCopies < 0 ) { throw new IllegalArgumentException("nCopies must be >= 0 but got " + nCopies); }
final StringBuilder b = new StringBuilder();
for ( int i = 0; i < nCopies; i++ ) {
b.append(s);
}
return b.toString();
}
/**
* Create a new byte array that's n copies of b
* @param b the byte to duplicate
* @param nCopies how many copies?
* @return a byte array
*/
public static byte[] dupBytes(final byte b, final int nCopies) {
final byte[] bytes = new byte[nCopies];
Arrays.fill(bytes, b);
return bytes;
}
/**
* Returns the number of occurrences of a boolean element in a boolean array.
* @param element
* @param array cannot be null
* @return
*/
public static int countBooleanOccurrences(final boolean element, final boolean[] array) {
Utils.nonNull(array);
int count = 0;
for (final boolean b : array) {
if (element == b) {
count++;
}
}
return count;
}
/**
* Splits expressions in command args by spaces and returns the array of expressions.
* Expressions may use single or double quotes to group any individual expression, but not both.
* @param args Arguments to parse.
* @return Parsed expressions.
*/
public static String[] escapeExpressions(final String args) {
Utils.nonNull(args);
// special case for ' and " so we can allow expressions
if (args.indexOf('\'') != -1) {
return escapeExpressions(args, "'");
} else if (args.indexOf('\"') != -1) {
return escapeExpressions(args, "\"");
} else {
return args.trim().split(" +");
}
}
/**
* Splits expressions in command args by spaces and the supplied delimiter and returns the array of expressions.
* @param args Arguments to parse.
* @param delimiter Delimiter for grouping expressions.
* @return Parsed expressions.
*/
private static String[] escapeExpressions(final String args, final String delimiter) {
String[] command = {};
final String[] split = args.split(delimiter);
for (int i = 0; i < split.length - 1; i += 2) {
final String arg = split[i].trim();
if (!arg.isEmpty()) { // if the unescaped arg has a size
command = ArrayUtils.addAll(command, arg.split(" +"));
}
command = ArrayUtils.addAll(command, split[i + 1]);
}
final String arg = split[split.length - 1].trim();
if (split.length % 2 == 1 && !arg.isEmpty()) { // if the last unescaped arg has a size
command = ArrayUtils.addAll(command, arg.split(" +"));
}
return command;
}
/**
* makes an array filled with n copies of the given char.
*/
public static byte[] repeatChars(final char c, final int n) {
return repeatBytes((byte)c, n);
}
/**
* makes an array filled with n copies of the given byte.
*/
public static byte[] repeatBytes(final byte b, final int n) {
if (n < 0){
throw new IllegalArgumentException("negative length");
}
final byte[] bytes = new byte[n];
Arrays.fill(bytes, b);
return bytes;
}
/**
* Make all combinations of N size of objects
*
* if objects = [A, B, C]
* if N = 1 => [[A], [B], [C]]
* if N = 2 => [[A, A], [B, A], [C, A], [A, B], [B, B], [C, B], [A, C], [B, C], [C, C]]
*
* @param objects list of objects
* @param n size of each combination
* @param withReplacement if false, the resulting permutations will only contain unique objects from objects
* @return a list with all combinations with size n of objects.
*/
public static List> makePermutations(final List objects, final int n, final boolean withReplacement) {
final List> combinations = new ArrayList<>();
if ( n == 1 ) {
for ( final T o : objects ) {
combinations.add(Collections.singletonList(o));
}
} else if (n > 1) {
final List> sub = makePermutations(objects, n - 1, withReplacement);
for ( final List subI : sub ) {
for ( final T a : objects ) {
if ( withReplacement || ! subI.contains(a) ) {
combinations.add(Utils.cons(a, subI));
}
}
}
}
return combinations;
}
/**
* @see #calcMD5(byte[])
*/
public static String calcMD5(final String s) {
Utils.nonNull(s, "s is null");
return calcMD5(s.getBytes());
}
/**
* Calculate the md5 for bytes, and return the result as a 32 character string
*
* @param bytes the bytes to calculate the md5 of
* @return the md5 of bytes, as a 32-character long string
*/
public static String calcMD5(final byte[] bytes) {
Utils.nonNull(bytes, "the input array cannot be null");
try {
return Utils.MD5ToString(MessageDigest.getInstance("MD5").digest(bytes));
}
catch ( final NoSuchAlgorithmException e ) {
throw new IllegalStateException("MD5 digest algorithm not present", e);
}
}
/**
* Calculates the MD5 for the specified file and returns it as a String
*
* @param file file whose MD5 to calculate
* @return file's MD5 in String form
* @throws IOException if the file could not be read
*/
public static String calculateFileMD5( final File file ) throws IOException{
return calculatePathMD5(file.toPath());
}
/**
* Calculates the MD5 for the specified file and returns it as a String
*
* @param path file whose MD5 to calculate
* @return file's MD5 in String form
* @throws IOException if the file could not be read
*/
public static String calculatePathMD5(final Path path) throws IOException {
// This doesn't have as nice error messages as FileUtils, but it's close.
String fname = path.toUri().toString();
if (!Files.exists(path)) {
throw new FileNotFoundException("File '" + fname + "' does not exist");
}
if (Files.isDirectory(path)) {
throw new IOException("File '" + fname + "' exists but is a directory");
}
if (!Files.isRegularFile(path)) {
throw new IOException("File '" + fname + "' exists but is not a regular file");
}
try {
final MessageDigest md = MessageDigest.getInstance("MD5");
final byte[] buff = new byte[8192];
final InputStream is = Files.newInputStream(path);
int bytesRead;
while ((bytesRead = is.read(buff)) > 0) {
md.update(buff, 0, bytesRead);
}
return Utils.MD5ToString(md.digest());
} catch ( final NoSuchAlgorithmException e ) {
throw new IllegalStateException("MD5 digest algorithm not present", e);
}
}
private static String MD5ToString(final byte[] bytes) {
final BigInteger bigInt = new BigInteger(1, bytes);
final String md5String = bigInt.toString(16);
return StringUtils.repeat("0", 32 - md5String.length()) + md5String;
}
/**
* Checks that an Object {@code object} is not null and returns the same object or throws an {@link IllegalArgumentException}
* @param object any Object
* @return the same object
* @throws IllegalArgumentException if a {@code o == null}
*/
public static T nonNull(final T object) {
return Utils.nonNull(object, "Null object is not allowed here.");
}
/**
* Checks that an {@link Object} is not {@code null} and returns the same object or throws an {@link IllegalArgumentException}
* @param object any Object
* @param message the text message that would be passed to the exception thrown when {@code o == null}.
* @return the same object
* @throws IllegalArgumentException if a {@code o == null}
*/
public static T nonNull(final T object, final String message) {
if (object == null) {
throw new IllegalArgumentException(message);
}
return object;
}
/**
* Checks that an {@link Object} is not {@code null} and returns the same object or throws an {@link IllegalArgumentException}
* @param object any Object
* @param message the text message that would be passed to the exception thrown when {@code o == null}.
* @return the same object
* @throws IllegalArgumentException if a {@code o == null}
*/
public static T nonNull(final T object, final Supplier message) {
if (object == null) {
throw new IllegalArgumentException(message.get());
}
return object;
}
/**
* Checks that a {@link Collection} is not {@code null} and that it is not empty.
* If it's non-null and non-empty it returns the input, otherwise it throws an {@link IllegalArgumentException}
* @param collection any Collection
* @param message a message to include in the output
* @return the original collection
* @throws IllegalArgumentException if collection is null or empty
*/
public static > T nonEmpty(T collection, String message){
nonNull(collection, "The collection is null: " + message);
if(collection.isEmpty()){
throw new IllegalArgumentException("The collection is empty: " + message);
} else {
return collection;
}
}
/**
* Checks that a {@link Collection} is not {@code null} and that it is not empty.
* If it's non-null and non-empty it returns the true
* @param collection any Collection
* @return true if the collection exists and has elements
*/
public static boolean isNonEmpty(Collection collection){
return collection != null && !collection.isEmpty();
}
/**
* Checks that a {@link String} is not {@code null} and that it is not empty.
* If it's non-null and non-empty it returns the input, otherwise it throws an {@link IllegalArgumentException}
* @param string any String
* @param message a message to include in the output
* @return the original string
* @throws IllegalArgumentException if string is null or empty
*/
public static String nonEmpty(String string, String message){
nonNull(string, "The string is null: " + message);
if(string.isEmpty()){
throw new IllegalArgumentException("The string is empty: " + message);
} else {
return string;
}
}
/**
* Checks that a {@link String} is not {@code null} and that it is not empty.
* If it's non-null and non-empty it returns the input, otherwise it throws an {@link IllegalArgumentException}
* @param string any String
* @return the original string
* @throws IllegalArgumentException if string is null or empty
*/
public static String nonEmpty(final String string){
return nonEmpty(string, "string must not be null or empty");
}
/**
* Checks that a {@link Collection} is not {@code null} and that it is not empty.
* If it's non-null and non-empty it returns the input, otherwise it throws an {@link IllegalArgumentException}
* @param collection any Collection
* @return the original collection
* @throws IllegalArgumentException if collection is null or empty
*/
public static > T nonEmpty(T collection){
return nonEmpty(collection, "collection must not be null or empty.");
}
/**
* Checks that the collection does not contain a {@code null} value (throws an {@link IllegalArgumentException} if it does).
* @param collection collection
* @param message the text message that would be pass to the exception thrown when c contains a null.
* @throws IllegalArgumentException if collection is null or contains any null elements
*/
public static void containsNoNull(final Collection collection, final String message) {
Utils.nonNull(collection, message);
//cannot use Collection.contains(null) here because this throws a NullPointerException when used with many Sets
if (collection.stream().anyMatch(v -> v == null)){
throw new IllegalArgumentException(message);
}
}
/**
* Checks that the collection does not contain a duplicate value (throws an {@link IllegalArgumentException} if it does).
* The implementation creates a {@link Set} as an intermediate step or detecting duplicates and returns this Set because
* it is sometimes useful to do so.
*
* @param c collection
* @param message A message to emit in case of error, in addition to reporting the first duplicate value found.
* @throws IllegalArgumentException if a {@code o == null}
*/
public static Set checkForDuplicatesAndReturnSet(final Collection c, final String message) {
final Set set = new LinkedHashSet<>();
for (final E element : c) {
if (!set.add(element)) {
throw new IllegalArgumentException(String.format(message + " Value %s appears more than once.", element.toString()));
}
}
return set;
}
/**
* Checks whether an index is within bounds considering a collection or array of a particular size
* whose first position index is 0
* @param index the query index.
* @param length the collection or array size.
* @return same value as the input {@code index}.
*/
public static int validIndex(final int index, final int length) {
if (index < 0) {
throw new IllegalArgumentException("the index cannot be negative: " + index);
} else if (index >= length) {
throw new IllegalArgumentException("the index points past the last element of the collection or array: " + index + " > " + (length -1));
}
return index;
}
/**
* Checks whether an index is within bounds considering a collection or array of a particular size
* whose first position index is 0
* @param index the query index.
* @param length the collection or array size.
* @param errorMessage the error message to use in case of an exception is thrown.
* @return same value as the input {@code index}.
*/
public static int validIndex(final int index, final int length, final String errorMessage) {
if (index < 0) {
throw new IllegalArgumentException(errorMessage);
} else if (index >= length) {
throw new IllegalArgumentException(errorMessage);
}
return index;
}
public static void validateArg(final boolean condition, final String msg){
if (!condition){
throw new IllegalArgumentException(msg);
}
}
public static void validateArg(final boolean condition, final Supplier msg){
if (!condition){
throw new IllegalArgumentException(msg.get());
}
}
/**
* Check a condition that should always be true and throw an {@link IllegalStateException} if false. If msg is not a
* String literal i.e. if it requires computation, use the Supplier version, below.
*/
public static void validate(final boolean condition, final String msg){
if (!condition){
throw new IllegalStateException(msg);
}
}
/**
* Check a condition that should always be true and throw an {@link IllegalStateException} if false.
*/
public static void validate(final boolean condition, final Supplier msg){
if (!condition){
throw new IllegalStateException(msg.get());
}
}
public static void printIf(final boolean condition, final Supplier msg){
if (condition){
System.out.println(msg.get());
}
}
/**
* Calculates the optimum initial size for a hash table given the maximum number
* of elements it will need to hold. The optimum size is the smallest size that
* is guaranteed not to result in any rehash/table-resize operations.
*
* @param maxElements The maximum number of elements you expect the hash table
* will need to hold
* @return The optimum initial size for the table, given maxElements
*/
public static int optimumHashSize ( final int maxElements ) {
return (int) (maxElements / JAVA_DEFAULT_HASH_LOAD_FACTOR) + 2;
}
/**
* Compares sections from to byte arrays to verify whether they contain the same values.
*
* @param left first array to compare.
* @param leftOffset first position of the first array to compare.
* @param right second array to compare.
* @param rightOffset first position of the second array to compare.
* @param length number of positions to compare.
*
* @throws IllegalArgumentException if
* - either {@code left} or {@code right} is {@code null} or
* - any off the offset or length combine point outside any of the two arrays
*
* @return {@code true} iff {@code length} is 0 or all the bytes in both ranges are the same two-by-two.
*/
public static boolean equalRange(final byte[] left, final int leftOffset, final byte[] right, final int rightOffset, final int length) {
Utils.nonNull(left, "left cannot be null");
Utils.nonNull(right, "right cannot be null");
validRange(length, leftOffset, left.length, "left");
validRange(length, rightOffset, right.length, "right");
for (int i = 0; i < length; i++) {
if (left[leftOffset + i] != right[rightOffset + i]) {
return false;
}
}
return true;
}
private static void validRange(final int length, final int offset, final int size, final String msg){
if (length < 0) {
throw new IllegalArgumentException(msg + " length cannot be negative");
}
if (offset < 0) {
throw new IllegalArgumentException(msg + " offset cannot be negative");
}
if (offset + length > size) {
throw new IllegalArgumentException(msg + " length goes beyond end of left array");
}
}
/**
* Skims out positions of an array returning a shorter one with the remaning positions in the same order.
* @param original the original array to splice.
* @param remove for each position in {@code original} indicates whether it should be spliced away ({@code true}),
* or retained ({@code false})
*
* @param the array type.
*
* @throws IllegalArgumentException if either {@code original} or {@code remove} is {@code null},
* or {@code remove length is different to {@code original}'s}, or {@code original} is not in
* fact an array.
*
* @return never {@code null}.
*/
public static T skimArray(final T original, final boolean[] remove) {
return skimArray(original,0,null,0,remove,0);
}
/**
* Skims out positions of an array returning a shorter one with the remaining positions in the same order.
*
*
* If the {@code dest} array provide is not long enough a new one will be created and returned with the
* same component type. All elements before {@code destOffset} will be copied from the input to the
* result array. If {@code dest} is {@code null}, a brand-new array large enough will be created where
* the position preceding {@code destOffset} will be left with the default value. The component type
* Will match the one of the {@code source} array.
*
*
* @param source the original array to splice.
* @param sourceOffset the first position to skim.
* @param dest the destination array.
* @param destOffset the first position where to copy the skimmed array values.
* @param remove for each position in {@code original} indicates whether it should be spliced away ({@code true}),
* or retained ({@code false})
* @param removeOffset the first position in the remove index array to consider.
*
* @param the array type.
*
* @throws IllegalArgumentException if either {@code original} or {@code remove} is {@code null},
* or {@code remove length is different to {@code original}'s}, or {@code original} is not in
* fact an array.
*
* @return never {@code null}.
*/
public static T skimArray(final T source, final int sourceOffset, final T dest, final int destOffset, final boolean[] remove, final int removeOffset) {
Utils.nonNull(source, "the source array cannot be null");
@SuppressWarnings("unchecked")
final Class sourceClazz = (Class) source.getClass();
if (!sourceClazz.isArray()) {
throw new IllegalArgumentException("the source array is not in fact an array instance");
}
final int length = Array.getLength(source) - sourceOffset;
if (length < 0) {
throw new IllegalArgumentException("the source offset goes beyond the source array length");
}
return skimArray(source,sourceOffset,dest,destOffset,remove,removeOffset,length);
}
/**
* Skims out positions of an array returning a shorter one with the remaning positions in the same order.
*
*
* If the {@code dest} array provide is not long enough a new one will be created and returned with the
* same component type. All elements before {@code destOffset} will be copied from the input to the
* result array. If {@code dest} is {@code null}, a brand-new array large enough will be created where
* the position preceding {@code destOffset} will be left with the default value. The component type
* Will match the one of the {@code source} array.
*
*
* @param source the original array to splice.
* @param sourceOffset the first position to skim.
* @param dest the destination array.
* @param destOffset the first position where to copy the skimed array values.
* @param remove for each position in {@code original} indicates whether it should be spliced away ({@code true}),
* or retained ({@code false})
* @param removeOffset the first position in the remove index array to consider.
* @param length the total number of position in {@code source} to consider. Thus only the {@code sourceOffset} to
* {@code sourceOffset + length - 1} region will be skimmed.
*
* @param the array type.
*
* @throws IllegalArgumentException if either {@code original} or {@code remove} is {@code null},
* or {@code remove length is different to {@code original}'s}, or {@code original} is not in
* fact an array.
*
* @return never {@code null}.
*/
public static T skimArray(final T source, final int sourceOffset, final T dest, final int destOffset,
final boolean[] remove, final int removeOffset, final int length) {
Utils.nonNull(source, "the source array cannot be null");
Utils.nonNull(remove, "the remove array cannot be null");
if (sourceOffset < 0) {
throw new IllegalArgumentException("the source array offset cannot be negative");
}
if (destOffset < 0) {
throw new IllegalArgumentException("the destination array offset cannot be negative");
}
if (removeOffset < 0) {
throw new IllegalArgumentException("the remove array offset cannot be negative");
}
if (length < 0) {
throw new IllegalArgumentException("the length provided cannot be negative");
}
final int removeLength = Math.min(remove.length - removeOffset,length);
if (removeLength < 0) {
throw new IllegalArgumentException("the remove offset provided falls beyond the remove array end");
}
@SuppressWarnings("unchecked")
final Class sourceClazz = (Class) source.getClass();
if (!sourceClazz.isArray()) {
throw new IllegalArgumentException("the source array is not in fact an array instance");
}
final Class destClazz = skimArrayDetermineDestArrayClass(dest, sourceClazz);
final int sourceLength = Array.getLength(source);
if (sourceLength < length + sourceOffset) {
throw new IllegalArgumentException("the source array is too small considering length and offset");
}
// count how many positions are to be removed.
int removeCount = 0;
final int removeEnd = removeLength + removeOffset;
for (int i = removeOffset; i < removeEnd; i++) {
if (remove[i]) {
removeCount++;
}
}
final int newLength = length - removeCount;
@SuppressWarnings("unchecked")
final T result = skimArrayBuildResultArray(dest, destOffset, destClazz, newLength);
// No removals, just copy the whole thing.
if (removeCount == 0) {
System.arraycopy(source, sourceOffset, result, destOffset, length);
} else if (length > 0) { // if length == 0 nothing to do.
int nextOriginalIndex = 0;
int nextNewIndex = 0;
int nextRemoveIndex = removeOffset;
while (nextOriginalIndex < length && nextNewIndex < newLength) {
while (nextRemoveIndex < removeEnd && remove[nextRemoveIndex++]) { nextOriginalIndex++; } // skip positions to be spliced.
// Since we make the nextNewIndex < newLength check in the while condition
// there is no need to include the following break, as is guaranteed not to be true:
// if (nextOriginalIndex >= length) break; // we reach the final (last positions are to be spliced.
final int copyStart = nextOriginalIndex;
while (++nextOriginalIndex < length && (nextRemoveIndex >= removeEnd || !remove[nextRemoveIndex])) { nextRemoveIndex++; }
final int copyEnd = nextOriginalIndex;
final int copyLength = copyEnd - copyStart;
System.arraycopy(source, sourceOffset + copyStart, result, destOffset + nextNewIndex, copyLength);
nextNewIndex += copyLength;
}
}
return result;
}
@SuppressWarnings("unchecked")
private static T skimArrayBuildResultArray(final T dest, final int destOffset, final Class destClazz, final int newLength) {
final T result;
if (dest == null) {
result = (T) Array.newInstance(destClazz.getComponentType(), newLength + destOffset);
} else if (Array.getLength(dest) < newLength + destOffset) {
result = (T) Array.newInstance(destClazz.getComponentType(),newLength + destOffset);
if (destOffset > 0) {
System.arraycopy(dest, 0, result, 0, destOffset);
}
} else {
result = dest;
}
return result;
}
@SuppressWarnings("unchecked")
private static Class skimArrayDetermineDestArrayClass(final T dest, final Class sourceClazz) {
final Class destClazz;
if (dest == null) {
destClazz = sourceClazz;
} else {
destClazz = (Class) dest.getClass();
if (destClazz != sourceClazz) {
if (!destClazz.isArray()) {
throw new IllegalArgumentException("the destination array class must be an array");
}
if (sourceClazz.getComponentType().isAssignableFrom(destClazz.getComponentType())) {
throw new IllegalArgumentException("the provided destination array class cannot contain values from the source due to type incompatibility");
}
}
}
return destClazz;
}
/**
* Checks if the read header contains any reads groups from non-Illumina and issue a warning of that's the case.
*/
public static void warnOnNonIlluminaReadGroups(final SAMFileHeader readsHeader, final Logger logger) {
Utils.nonNull(readsHeader, "header");
Utils.nonNull(logger, "logger");
if (readsHeader.getReadGroups().stream().anyMatch(rg -> NGSPlatform.fromReadGroupPL(rg.getPlatform()) != NGSPlatform.ILLUMINA)){
logger.warn("This tool has only been well tested on ILLUMINA-based sequencing data. For other data use at your own risk.");
}
}
/**
* Boolean xor operation. Only true if x != y.
*
* @param x a boolean
* @param y a boolean
* @return true if x != y
*/
public static boolean xor(final boolean x, final boolean y) {
return x != y;
}
/**
* Find the last occurrence of the query sequence in the reference sequence
*
* Returns the index of the last occurrence or -1 if the query sequence is not found
*
* @param reference the reference sequence
* @param query the query sequence
*/
public static int lastIndexOf(final byte[] reference, final byte[] query) {
int queryLength = query.length;
// start search from the last possible matching position and search to the left
for (int r = reference.length - queryLength; r >= 0; r--) {
int q = 0;
while (q < queryLength && reference[r+q] == query[q]) {
q++;
}
if (q == queryLength) {
return r;
}
}
return -1;
}
/**
* Simple wrapper for sticking elements of a int[] array into a List
* @param ar - the array whose elements should be listified
* @return - a List where each element has the same value as the corresponding index in @ar
*/
public static List listFromPrimitives(final int[] ar) {
Utils.nonNull(ar);
return Ints.asList(ar);
}
/**
* Concatenates a series of {@link Iterator}s (all of the same type) into a single {@link Iterator}.
* @param iterator an {@link Iterator} of {@link Iterator}s
* @param the type of the iterator
* @return an {@link Iterator} over the underlying {@link Iterator}s
*/
public static Iterator concatIterators(final Iterator> iterator) {
Utils.nonNull(iterator, "iterator");
return new AbstractIterator() {
Iterator subIterator;
@Override
protected T computeNext() {
if (subIterator != null && subIterator.hasNext()) {
return subIterator.next();
}
while (iterator.hasNext()) {
subIterator = iterator.next().iterator();
if (subIterator.hasNext()) {
return subIterator.next();
}
}
return endOfData();
}
};
}
public static Stream stream(final Enumeration enumeration) {
return Utils.stream(Iterators.forEnumeration(enumeration));
}
public static Stream stream(final Iterable iterable) {
return StreamSupport.stream(iterable.spliterator(), false);
}
public static Stream stream(final Iterator iterator) {
return stream(() -> iterator);
}
/**
* Returns a function that always returns its input argument. Unlike {@link Function#identity()} the returned
* function is also serializable.
*
* @param the type of the input and output objects to the function
* @return a function that always returns its input argument
*/
@SuppressWarnings("unchecked")
public static Function identityFunction() {
return (Function & Serializable) t -> t;
}
/**
* Like Guava's {@link Iterators#transform(Iterator, com.google.common.base.Function)}, but runs a fixed number
* ({@code numThreads}) of transformations in parallel, while maintaining ordering of the output iterator.
* This is useful if the transformations are CPU intensive.
*/
public static Iterator transformParallel(final Iterator fromIterator, final Function function, final int numThreads) {
Utils.nonNull(fromIterator, "fromIterator");
Utils.nonNull(function, "function");
Utils.validateArg(numThreads >= 1, "numThreads must be at least 1");
if (numThreads == 1) { // defer to Guava for single-threaded case
return Iterators.transform(fromIterator, new com.google.common.base.Function() {
@Nullable
@Override
public T apply(@Nullable final F input) {
return function.apply(input);
}
});
}
// use an executor service for the multi-threaded case
final ExecutorService executorService = Executors.newFixedThreadPool(numThreads);
final Queue> futures = new LinkedList<>();
return new AbstractIterator() {
@Override
protected T computeNext() {
try {
while (fromIterator.hasNext()) {
if (futures.size() == numThreads) {
return futures.remove().get();
}
final F next = fromIterator.next();
final Future future = executorService.submit(() -> function.apply(next));
futures.add(future);
}
if (!futures.isEmpty()) {
return futures.remove().get();
}
executorService.shutdown();
return endOfData();
} catch (InterruptedException | ExecutionException e) {
throw new GATKException("Problem running task", e);
}
}
};
}
/** Gets duplicated items in the collection. */
public static Set getDuplicatedItems(final Collection objects) {
final Set unique = new HashSet<>();
return objects.stream()
.filter(name -> !unique.add(name))
.collect(Collectors.toSet());
}
/**
* Return the given {@code dateTime} formatted as string for display.
* @param dateTime the date/time to be formatted
* @return String representing the {@code dateTime}.
*/
public static String getDateTimeForDisplay(final ZonedDateTime dateTime) {
return dateTime.format(longDateTimeFormatter);
}
/**
* Set the Locale to US English so that numbers will always be formatted in the US style.
*/
public static void forceJVMLocaleToUSEnglish() {
Locale.setDefault(Locale.US);
}
/**
* Streams and sorts a collection of objects and returns the integer median entry of the sorted list
* @param values List of sortable entries from which to select the median
*/
public static > T getMedianValue(List values) {
final List sorted = values.stream().sorted().collect(Collectors.toList());
return sorted.get(sorted.size() / 2);
}
/**
* Splits a String using indexOf instead of regex to speed things up.
* This method produces the same results as {@link String#split(String)} and {@code String.split(String, 0)},
* but has been measured to be ~2x faster (see {@code StringSplitSpeedUnitTest} for details).
*
* @param str the string to split.
* @param delimiter the delimiter used to split the string.
* @return A {@link List} of {@link String} tokens.
*/
public static List split(final String str, final char delimiter) {
final List tokens;
if ( str.isEmpty() ) {
tokens = new ArrayList<>(1);
tokens.add("");
}
else {
tokens = ParsingUtils.split(str, delimiter);
removeTrailingEmptyStringsFromEnd(tokens);
}
return tokens;
}
/**
* Splits a String using indexOf instead of regex to speed things up.
* If given an empty delimiter, will return each character in the string as a token.
* This method produces the same results as {@link String#split(String)} and {@code String.split(String, 0)},
* but has been measured to be ~2x faster (see {@code StringSplitSpeedUnitTest} for details).
*
* @param str the string to split.
* @param delimiter the delimiter used to split the string.
* @return A {@link List} of {@link String} tokens.
*/
public static List split(final String str, final String delimiter) {
// This is 10 because the ArrayList default capacity is 10 (but private).
return split(str, delimiter, 10);
}
/**
* Splits a given {@link String} using {@link String#indexOf(String)} instead of regex to speed things up.
* If given an empty delimiter, will return each character in the string as a token.
* This method produces the same results as {@link String#split(String)} and {@code String.split(String, 0)},
* but has been measured to be ~2x faster (see {@code StringSplitSpeedUnitTest} for details).
*
* @param str The {@link String} to split.
* @param delimiter The delimiter used to split the {@link String}.
* @param expectedNumTokens The number of tokens expected (used to initialize the capacity of the {@link ArrayList}).
* @return A {@link List} of {@link String} tokens.
*/
private static List split(final String str, final String delimiter, final int expectedNumTokens) {
final List result;
if ( str.isEmpty() ) {
result = new ArrayList<>(1);
result.add("");
}
else if ( delimiter.isEmpty() ) {
result = new ArrayList<>(str.length());
for ( int i = 0; i < str.length(); ++i ) {
result.add(str.substring(i, i + 1));
}
}
else if ( delimiter.length() == 1 ) {
result = split(str, delimiter.charAt(0));
}
else {
result = new ArrayList<>(expectedNumTokens);
int delimiterIdx = -1;
int tokenStartIdx = delimiterIdx + 1;
do {
delimiterIdx = str.indexOf(delimiter, tokenStartIdx);
final String token = (delimiterIdx != -1 ? str.substring(tokenStartIdx, delimiterIdx) : str.substring(tokenStartIdx));
result.add(token);
tokenStartIdx = delimiterIdx + delimiter.length();
} while ( delimiterIdx != -1 );
removeTrailingEmptyStringsFromEnd(result);
}
return result;
}
private static void removeTrailingEmptyStringsFromEnd(final List result) {
// Remove all trailing empty strings to emulate the behavior of String.split:
// We remove items from the end of the list to our index
// so that we can take advantage of better performance of removing items from the end
// of certain concrete lists:
while ( (!result.isEmpty()) && (result.get(result.size() - 1).isEmpty()) ) {
result.remove(result.size() - 1);
}
}
/**
* Take a map of a value to a list and reverse it. Note that no assumptions of uniqueness are made, so returned
* values are also lists.
*
* For example:
*
* Input:
* k -> {a,b}
* j -> {a}
*
* Output:
* a -> {k,j}
* b -> {k}
*
* Any sorting in the input map will be lost in the output.
*
* @param somethingToListMap a map from a value to a list of values. Never {@code null}
* @param class of the key of the input
* @param class of the values in the list of the input
* @return A new mapping from class of values to set of keys. Never {@code null}
*/
public static Map> getReverseValueToListMap(final Map> somethingToListMap) {
final Map> result = new HashMap<>();
for (final Map.Entry> entry : somethingToListMap.entrySet()) {
entry.getValue().forEach(v -> result.computeIfAbsent(v, k -> new HashSet<>()).add(entry.getKey()));
}
return result;
}
/**
* Convenience function that formats a percentage as a %.2f string
*
* @param x number of objects part of total that meet some criteria
* @param total count of all objects, including x
* @return a String percent rate, or NA if total == 0
*/
public static String formattedPercent(final long x, final long total) {
return total == 0 ? "NA" : String.format("%.2f", (100.0*x) / total);
}
/**
* Convenience function that formats a ratio as a %.2f string
*
* @param num number of observations in the numerator
* @param denom number of observations in the denumerator
* @return a String formatted ratio, or NA if all == 0
*/
public static String formattedRatio(final long num, final long denom) {
return denom == 0 ? "NA" : String.format("%.2f", num / (1.0 * denom));
}
/**
* Given a collection of strings and a collection of regular expressions, generates the set of strings that match
* any expression
* @param sourceValues collection of strings from which to to select
* @param filterExpressions list of expressions to use for matching
* @param exactMatch If true match filters exactly, otherwise use as both exact and regular expressions
* @return A new set strings from sourceValues that satisfy at least one of the expressions in sampleExpressions
*/
public static Set filterCollectionByExpressions(final Collection sourceValues, final Collection filterExpressions, final boolean exactMatch) {
Utils.nonNull(filterExpressions);
Utils.nonNull(sourceValues);
final Set filteredValues = new LinkedHashSet<>();
Collection patterns = null;
if (!exactMatch) {
patterns = compilePatterns(filterExpressions);
}
for (final String value : sourceValues) {
if (filterExpressions.contains(value)) {
filteredValues.add(value);
} else if (!exactMatch) {
for (final Pattern pattern : patterns) {
if (pattern.matcher(value).find()) {
filteredValues.add(value);
break;
}
}
}
}
return filteredValues;
}
private static Collection compilePatterns(final Collection filters) {
final Collection patterns = new ArrayList();
for (final String filter: filters) {
patterns.add(Pattern.compile(filter));
}
return patterns;
}
/**
* Runs a task in parallel returning it returned result.
* This call will wait until such task is completed.
* @param threads number of threads requested. 0 would result in using a system default,
* usually the host number of CPU cores.
* @param supplier the task to run.
* @param the type of the return.
* @return whatever the input task returns in the end, it can be {@code null}.
* @throws GATKException if the run was interrupted or resulted in a checked exception. Unchecked exceptions and Error
* progragate as they are.
*/
public static T runInParallel(final int threads, final Supplier supplier) {
final ForkJoinPool threadPool = threads == 0 ? new ForkJoinPool() : new ForkJoinPool(threads);
try {
return threadPool.submit(supplier::get).get();
} catch (final InterruptedException e) {
throw new GATKException("task interrupted", e);
} catch (final ExecutionException e) {
final Throwable cause = e.getCause();
if (cause instanceof RuntimeException) {
throw (RuntimeException) cause;
} else if (cause instanceof Error) {
throw (Error) cause;
} else {
throw new GATKException("exception when executing parallel task ", cause);
}
}
}
}
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