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    ??srCorg.clulab.assembly.relations.classifier.AssemblyRelationClassifiert??ڛ?yL
classifiert Lorg/clulab/learning/Classifier;LclassifierTypetLjava/lang/String;xpsr2org.clulab.learning.L1LogisticRegressionClassifier?x?UI??xr'org.clulab.learning.LiblinearClassifierBpw?:{?	DCZbiasDepsI9org$clulab$learning$LiblinearClassifier$$biasFeatureIndexLclassWeightstLscala/Option;L7org$clulab$learning$LiblinearClassifier$$featureLexiconq~L5org$clulab$learning$LiblinearClassifier$$labelLexiconq~L.org$clulab$learning$LiblinearClassifier$$modeltLde/bwaldvogel/liblinear/Model;L
solverTypet$Lde/bwaldvogel/liblinear/SolverType;xp????z?G?{????srscala.None$FP$?Sʔ?xrscala.Option?i7??ftxpsr
scala.Some"?i^??tLxtLjava/lang/Object;xq~srorg.clulab.struct.Lexiconޕu?S??IsavedMemoryL org$clulab$struct$Lexicon$$indext&Lscala/collection/mutable/ArrayBuffer;L"org$clulab$struct$Lexicon$$lexicont"Lscala/collection/mutable/HashMap;xpsr$scala.collection.mutable.ArrayBuffer8?S???sIinitialSizeIsize0[arrayt[Ljava/lang/Object;xpXpur[Ljava.lang.Object;??X?s)lxptie2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >xcomp controlled:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=phosphorylate xcomp [lemma='daf-16'] controlledtse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation xcomp [lemma='daf-16'] controlledt0e2: ents2Label-mention-ngram: results in nuclearte2: outgoing: >xcomptme1: trigger-arg-path: phosphorylates:Positive_regulation xcomp Gene_or_gene_productt"e1: all-labels: PossibleControllert*e2: args2Role-mention-ngram: exclusion andt?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation dep [lemma='reduce'] e2:reduced:Negative_activationte1: outgoing: >dobjt'e2: args2Role-mention-ngram: in nucleartGe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj Gene_or_gene_productt%e1: args2Role-mention-ngram: directlytcross-sent:falsetEe1: trigger-arg-path: Positive_regulation xcomp controlled:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controller:Gene_or_gene_producttitrigger-to-trigger-path: e1:phosphorylates:Positive_regulation dep e2:reduced:Negative_activationt9e2: trigger-arg-path: reduced >nsubj Gene_or_gene_producttie2: trigger-arg-path: reduced:Negative_activation >xcomp [lemma='daf-16'] controlled:Gene_or_gene_productt;e1: trigger-arg-path: Positive_regulation xcomp [lemma='daf-16'] Gene_or_gene_productte2: CONTROLLER: 1t+e2: args2Role-mention-ngram: CONTROLLER andtDe1: trigger-arg-path: phosphorylates nsubj [lemma='foxo'] controller:Gene_or_gene_productte2: label: Negative_activationt0e1: args2Role-mention-ngram: CONTROLLER directlyt&e1: ents2Label-mention-ngram: directlyte2: incoming: nsubj [lemma='foxo'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj controllerte1: all-labels: Eventt/e2: trigger-arg-path: reduced >nsubj controllert-e2: args2Role-mention-ngram: and this resultst$e2: args2Role-mention-ngram: reducedt"e2: all-labels: PossibleControllert'e1: args2Role-mention-ngram: CONTROLLERt'e2: args2Role-mention-ngram: results inte2: trigger: reducedt\e2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='foxo'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: andt*e2: ents2Label-mention-ngram: this resultst+e2: ents2Label-mention-ngram: exclusion andte1: trigger: phosphorylateste1: incoming: xcomp [lemma='daf-16'] Gene_or_gene_productt_e1: trigger-arg-path: phosphorylates:Positive_regulation xcomp [lemma='daf-16'] controlled:Gene_or_gene_productt@e2: trigger-arg-path: reduced >xcomp [lemma='daf-16'] controlledtxe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='foxo'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: phosphorylates SHAREDt@e2: trigger-arg-path: lemmatizedTrigger=reduce >xcomp controlledte2: CONTROLLED: 1t1e2: args2Role-mention-ngram: in nuclear exclusiontXe2: trigger-arg-path: reduced:Negative_activation >xcomp controlled:Gene_or_gene_producttge2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='foxo'] controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='foxo'] controllertIe1: trigger-arg-path: Positive_regulation nsubj controllert@e1: trigger-arg-path: phosphorylates xcomp Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj Gene_or_gene_productt%e2: ents2Label-mention-ngram: resultst9e2: args2Role-mention-ngram: therefore reduced CONTROLLEDte1: CONTROLLER: 1tinterceding-token ngrams: /tLe2: trigger-arg-path: Negative_activation >xcomp [lemma='daf-16'] controlledt[e2: trigger-arg-path: lemmatizedTrigger=reduce >xcomp [lemma='daf-16'] Gene_or_gene_productt;e2: trigger-arg-path: Negative_activation >nsubj controllerte2: args2Role-mention-ngram: int!e2: args2Role-mention-ngram: thistnsubj controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: nucleartEe2: trigger-arg-path: Negative_activation >xcomp Gene_or_gene_productt/e2: ents2Label-mention-ngram: nuclear exclusiont&e2: args2Role-mention-ngram: thereforetJe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj Gene_or_gene_productt.e2: args2Role-mention-ngram: therefore reducedt e2: args2Role-mention-ngram: andt'e2: args2Role-mention-ngram: CONTROLLEDt>e2: trigger-arg-path: reduced >nsubj [lemma='foxo'] controllert9e2: trigger-arg-path: reduced >xcomp Gene_or_gene_productt(e2: ents2Label-mention-ngram: SHARED andt=e1-label: Positive_regulation + e2-label: Negative_activationtVe2: trigger-arg-path: Negative_activation >xcomp [lemma='daf-16'] Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation xcomp controlledtUe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='foxo'] Gene_or_gene_producttRe2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='foxo'] controllerttrigger-dist: 2t)e2: args2Role-mention-ngram: this resultstTe1: trigger-arg-path: phosphorylates:Positive_regulation xcomp controlledtQe2: trigger-arg-path: lemmatizedTrigger=reduce >xcomp [lemma='daf-16'] controlledte2: all-labels: ComplexEventt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate xcomp Gene_or_gene_productt5e1: ents2Label-mention-ngram: directly phosphorylatestpe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='foxo'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCTt/e2: ents2Label-mention-ngram: therefore reducedtPe2: trigger-arg-path: Negative_activation >xcomp controlled:Gene_or_gene_producttKe1: trigger-arg-path: phosphorylates nsubj [lemma='foxo'] controllertSe2: trigger-arg-path: reduced >nsubj [lemma='foxo'] controller:Gene_or_gene_productte1: all-labels: ComplexEventtDe2: trigger-arg-path: reduced >nsubj controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: and this resultstCe2: trigger-arg-path: reduced:Negative_activation >xcomp controlledtTe2: trigger-arg-path: Negative_activation >nsubj [lemma='foxo'] Gene_or_gene_productt%e2: args2Role-mention-ngram: and thist~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='foxo'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='foxo'] controllert'e1: args2Role-mention-ngram: CONTROLLEDt$e2: args2Role-mention-ngram: nucleart;e2: trigger-arg-path: Negative_activation >xcomp controlledt+e2: ents2Label-mention-ngram: and thereforete1: all-labels: RegulationtJe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT directly phosphorylatestze2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >xcomp [lemma='daf-16'] controlled:Gene_or_gene_productt0e1: args2Role-mention-ngram: directly CONTROLLEDt'e2: args2Role-mention-ngram: CONTROLLERtUe2: trigger-arg-path: lemmatizedTrigger=reduce >xcomp controlled:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controllertinterceding-tokens-full-span: /tUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controller:Gene_or_gene_producttMe2: trigger-arg-path: reduced:Negative_activation >nsubj Gene_or_gene_producttJe1: trigger-arg-path: phosphorylates:Positive_regulation xcomp [lemma='daf-16'] Gene_or_gene_productte2: all-labels: Eventte2: incoming: xcomp [lemma='daf-16'] controlled:Gene_or_gene_producttae2: trigger-arg-path: Negative_activation >xcomp [lemma='daf-16'] controlled:Gene_or_gene_producttse1: trigger-arg-path: Positive_regulation dep e2:reduced:Negative_activationt?e1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation dep [lemma='reduce'] e2:reduced:Negative_activationt]e1: trigger-arg-path: directly:Positive_regulation nsubj themet&interceding-token ngrams: adds anothertVe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: witht-interceding-token ngrams: of complexity sincet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atfx'] Gene_or_gene_productt?e2: trigger-arg-path: represses >dobj [lemma='tax1'] controlledtYe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='tax1'] Gene_or_gene_productt@e2: trigger-arg-path: represses >nsubj controller:Generic_entityt[e2: trigger-arg-path: Negative_activation >nsubj [lemma='factor'] controller:Generic_entityt'e1: ents2Label-mention-ngram: interactstTe2: trigger-arg-path: represses:Negative_activation >nsubj controller:Generic_entitytue2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='factor'] controller:Generic_entitytLe1: trigger-arg-path: Binding >prep_with [lemma='atfx'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atfx'] theme:Gene_or_gene_productt,interceding-token ngrams: adds another leveltUe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj controllertinterceding-token ngrams: oftVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='atfx'] Gene_or_gene_producttCe1: trigger-arg-path: Binding >prep_with theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED interacts withtIe1: trigger-arg-path: interacts:Binding >nsubj theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt0e2: trigger-arg-path: represses >dobj controlledt=e1: trigger-arg-path: Binding >prep_with [lemma='atfx'] themetCe1: trigger-arg-path: interacts:Binding >nsubj Gene_or_gene_productt7e1: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCTtIe2: trigger-arg-path: represses >dobj [lemma='tax1'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: interacts withtNe1: trigger-arg-path: interacts >prep_with [lemma='atfx'] Gene_or_gene_productt?shortest-path: advcl [lemma='repress'] >nsubj [lemma='factor']t]e2: trigger-arg-path: represses:Negative_activation >dobj [lemma='tax1'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj controlledt0e1: trigger-arg-path: interacts >prep_with themetEe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj Generic_entitytGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='atfx'] themet!interceding-token ngrams: anothertDe2: trigger-arg-path: represses:Negative_activation >dobj controlledtNe2: trigger-arg-path: represses:Negative_activation >dobj Gene_or_gene_producttFe2: trigger-arg-path: represses >nsubj [lemma='factor'] Generic_entitytje2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='factor'] Generic_entitytEe2: trigger-arg-path: represses:Negative_activation >nsubj controllert.e1: trigger-arg-path: Binding >prep_with themete2: outgoing: >dobjtJe2: trigger-arg-path: Negative_activation >nsubj controller:Generic_entitytLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj Gene_or_gene_productt-interceding-token ngrams: level of complexitytge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atfx'] Gene_or_gene_producttQe2: trigger-arg-path: represses >nsubj [lemma='factor'] controller:Generic_entityt?e1: trigger-arg-path: interacts >prep_with Gene_or_gene_productt$interceding-token ngrams: complexitytae2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='factor'] controller:Generic_entityt@e2: trigger-arg-path: lemmatizedTrigger=repress >dobj controlledtUe2: trigger-arg-path: lemmatizedTrigger=repress >dobj controlled:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atfx'] themet:e2: trigger-arg-path: Negative_activation >dobj controlledt\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='atfx'] theme:Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='tax1'] themetAe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with themetDe2: trigger-arg-path: Negative_activation >dobj Gene_or_gene_producttZe2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='factor'] Generic_entitytJe2: trigger-arg-path: lemmatizedTrigger=repress >dobj Gene_or_gene_producttAe1: ents2Label-mention-ngram: interacts with GENE_OR_GENE_PRODUCTte1: all-labels: BindingtYe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj Generic_entityt1e2: args2Role-mention-ngram: CONTROLLER represseste1: incoming: advcl >nsubjt,e1: args2Role-mention-ngram: THEME interactstie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='tax1'] controlledtOe2: trigger-arg-path: Negative_activation >dobj controlled:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with themetTe1: trigger-arg-path: interacts >prep_with [lemma='atfx'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atfx'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='tax1'] controlledtadvcl [lemma='repress'] e2:represses:Negative_activationt'interceding-token ngrams: of complexityt4e1: trigger-arg-path: interacts:Binding >nsubj themetSe2: trigger-arg-path: represses:Negative_activation >dobj [lemma='tax1'] controlledtae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='factor'] Generic_entityt5e2: trigger-arg-path: represses >nsubj Generic_entityt/interceding-token ngrams: complexity since thistEe2: trigger-arg-path: represses >dobj controlled:Gene_or_gene_producttinterceding-token ngrams: leveltXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atfx'] themet^e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with theme:Gene_or_gene_producttee2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='factor'] controller:Generic_entitytMe1: trigger-arg-path: interacts:Binding >prep_with theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: withtIe2: trigger-arg-path: represses:Negative_activation >nsubj Generic_entityt=e1: trigger-arg-path: Binding >prep_with Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='tax1'] controlled:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED represseste1: trigger: interactstBe2: trigger-arg-path: represses >nsubj [lemma='factor'] controllert,e1: trigger-arg-path: interacts >nsubj themetTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Gene_or_gene_producttIinterceding-tokens-full-span: adds another level of complexity since thiste1: THEME: 1tPe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj controller:Generic_entitytJe1: trigger-arg-path: interacts >nsubj [lemma='tax1'] Gene_or_gene_producttGe1: trigger-arg-path: interacts:Binding >prep_with Gene_or_gene_productt^e2: trigger-arg-path: Negative_activation >dobj [lemma='tax1'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubj theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: interacts withtie2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj controlled:Gene_or_gene_productt$interceding-token ngrams: since thist*interceding-token ngrams: another level oftinterceding-token ngrams: addstEe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj themet:e2: trigger-arg-path: represses >dobj Gene_or_gene_producttinterceding-token ngrams: thist'e2: ents2Label-mention-ngram: repressestPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with Gene_or_gene_productt&e2: args2Role-mention-ngram: repressest'interceding-token ngrams: another leveltCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='tax1'] themet"e1: args2Role-mention-ngram: THEMEtxe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='tax1'] controlled:Gene_or_gene_productt1e1-label: Binding + e2-label: Negative_activationt9e1: trigger-arg-path: Binding >nsubj [lemma='tax1'] themet*interceding-token ngrams: complexity sincetRe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='factor'] controllerte1: label: Bindingt8e1: trigger-arg-path: interacts:Binding >prep_with themetTe2: trigger-arg-path: represses >dobj [lemma='tax1'] controlled:Gene_or_gene_productte2: trigger: repressestYe2: trigger-arg-path: represses:Negative_activation >dobj controlled:Gene_or_gene_producttPe2: trigger-arg-path: Negative_activation >nsubj [lemma='factor'] Generic_entityt1e1: args2Role-mention-ngram: THEME interacts witht&e1: args2Role-mention-ngram: interactstfe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='factor'] controllert'e1: args2Role-mention-ngram: with THEMEt1e1: args2Role-mention-ngram: interacts with THEMEtZe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax1'] themethe2: trigger-arg-path: represses:Negative_activation >dobj [lemma='tax1'] controlled:Gene_or_gene_producttAe1: trigger-arg-path: interacts >nsubj theme:Gene_or_gene_producttIe2: trigger-arg-path: Negative_activation >dobj [lemma='tax1'] controlledtHe1: trigger-arg-path: Binding >nsubj [lemma='tax1'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='tax1'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: SHARED represses SHAREDt;e1: trigger-arg-path: interacts >nsubj Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='atfx'] theme:Gene_or_gene_producttVe2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='factor'] controllertAe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj controllertEe1: trigger-arg-path: interacts >prep_with theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj Gene_or_gene_producttatrigger-to-trigger-path: e1:interacts:Binding advcl e2:represses:Negative_activationtce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax1'] Gene_or_gene_productt?e2: trigger-arg-path: Negative_activation >nsubj Generic_entitytLe2: trigger-arg-path: Negative_activation >nsubj [lemma='factor'] controllert.e2: ents2Label-mention-ngram: represses SHAREDt.e1: ents2Label-mention-ngram: SHARED interactst"interceding-token ngrams: level oftXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with Gene_or_gene_producttsortest-path-dist: 5tRe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='tax1'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj controller:Generic_entitytTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax1'] themete1: all-labels: SimpleEventt?e1: trigger-arg-path: interacts >prep_with [lemma='atfx'] themetPe1: trigger-arg-path: interacts >nsubj [lemma='tax1'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: represses CONTROLLEDt=e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj themet1e2: trigger-arg-path: represses >nsubj controllertSe2: trigger-arg-path: Negative_activation >dobj [lemma='tax1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nucleoporin'] themet;e2: trigger-arg-path: Positive_regulation >agent >nn Familytresolved: truettrigger-dist: 1t#anaphor-basic: label: Generic_eventtGe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between themetKe2: trigger-arg-path: mediated:Positive_regulation >nsubjpass Generic_eventtDe1: trigger-arg-path: interaction >prep_between [lemma='tax1'] themet@e1: trigger-arg-path: Binding >prep_between [lemma='tax1'] themetFe2: trigger-arg-path: Positive_regulation >agent >nn controller:Familytae1: trigger-arg-path: interaction:Binding >prep_between [lemma='tax1'] theme:Gene_or_gene_productt(anaphor-basic: all-labels: Generic_eventtOe2: trigger-arg-path: mediated:Positive_regulation >agent >nn controller:FamilytBe2: trigger-arg-path: mediated >nsubjpass controlled:Generic_eventtYe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn controllertDe2: trigger-arg-path: mediated:Positive_regulation >agent >nn Familyt(e1: args2Role-mention-ngram: interactiontKe1: trigger-arg-path: interaction >prep_between [lemma='nucleoporin'] themetXe2: trigger-arg-path: mediated >nsubjpass [lemma='interaction'] controlled:Generic_eventt,e2: ents2Label-mention-ngram: interaction istAshortest-path: auxpass [lemma='be']t\e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between theme:Gene_or_gene_productt-anaphor-basic: all-labels: PossibleControllerte2: incoming: prep_between [lemma='nucleoporin'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >agent >nn controllertVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between Gene_or_gene_productt)e2: ents2Label-mention-ngram: is mediatedt;e2: trigger-arg-path: mediated >agent >nn controller:Familyt{e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] Familyt$e2: ents2Label-mention-ngram: by thetUe2: trigger-arg-path: Positive_regulation >nsubjpass [lemma='interaction'] controlledtMe2: trigger-arg-path: mediated >nsubjpass [lemma='interaction'] Generic_eventtBe2: trigger-arg-path: Positive_regulation >nsubjpass Generic_eventt/e2: ents2Label-mention-ngram: the aminoterminalt e2: ents2Label-mention-ngram: byt#e2: all-labels: Positive_regulationtFe1: trigger-arg-path: Binding >prep_between theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: mediatedt4e2: trigger-arg-path: mediated >nsubjpass controlledt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controller:Familyt%e1: ents2Label-mention-ngram: betweent$e2: ents2Label-mention-ngram: FAMILYt(e2: args2Role-mention-ngram: is mediatedtVe2: trigger-arg-path: mediated:Positive_regulation >nsubjpass controlled:Generic_eventte2: all-labels: RegulationtSe1: trigger-arg-path: interaction:Binding >prep_between [lemma='nucleoporin'] themet5e2: ents2Label-mention-ngram: interaction is mediatedt:e1: ents2Label-mention-ngram: between GENE_OR_GENE_PRODUCTt7e2: trigger-arg-path: mediated >nsubjpass Generic_eventtYe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass controlledt}e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventte2: args2Role-mention-ngram: bytRe1: trigger-arg-path: interaction:Binding >prep_between theme:Gene_or_gene_producttLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='tax1'] themetae2: trigger-arg-path: Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] Familyt"anaphor-basic: all-labels: Bindingte2: incoming: nsubjpass controlledtHe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass Generic_eventtle2: trigger-arg-path: mediated:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventtme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='tax1'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCTtee2: trigger-arg-path: Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controllerte2: trigger: mediatedtVe1: trigger-arg-path: Binding >prep_between [lemma='nucleoporin'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn Familytle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nucleoporin'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: aminoterminal FAMILYt#e2: args2Role-mention-ngram: by thet"shortest-path: auxpasstge2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass controlled:Generic_eventtJe2: trigger-arg-path: mediated >nsubjpass [lemma='interaction'] controlledtOe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between themetJe1: trigger-arg-path: interaction >prep_between theme:Gene_or_gene_producttle2: trigger-arg-path: Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controller:Familyt!e1: ents2Label-mention-ngram: thetUe1: trigger-arg-path: Binding >prep_between [lemma='tax1'] theme:Gene_or_gene_productt\e1: trigger-arg-path: Binding >prep_between [lemma='nucleoporin'] theme:Gene_or_gene_productt:e1: ents2Label-mention-ngram: and the GENE_OR_GENE_PRODUCTt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='tax1'] themet9e2: args2Role-mention-ngram: the aminoterminal CONTROLLERt0e2: trigger-arg-path: mediated >agent >nn FamilytHe2: trigger-arg-path: mediated:Positive_regulation >agent >nn controllertse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='tax1'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME and thetre2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='motif'] >nn [lemma='zinc-finger'] controller:Familyt-e2: ents2Label-mention-ngram: mediated by thetHe2: trigger-arg-path: mediated:Positive_regulation >nsubjpass controlledtke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='tax1'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: andt`trigger-to-trigger-path: e1:interaction:Generic_event prep_between [lemma='tax1'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: interaction betweentinterceding-tokens-full-span: tDe1: trigger-arg-path: interaction >prep_between Gene_or_gene_productt6e2: ents2Label-mention-ngram: the aminoterminal FAMILYt@e1: trigger-arg-path: Binding >prep_between Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nucleoporin'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: interaction between THEMEt4anaphor-basic: ents2Label-mention-ngram: interactiontrtrigger-to-trigger-path: e1:interaction:Generic_event agent [lemma='motif'] >nn [lemma='zinc-finger'] controller:FamilytOe1: trigger-arg-path: Binding >prep_between [lemma='tax1'] Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn Familyt&e1: args2Role-mention-ngram: the THEMEt.e1: args2Role-mention-ngram: between THEME andt)e2: ents2Label-mention-ngram: interactiontke2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='motif'] >nn [lemma='zinc-finger'] controllert=e1: trigger-arg-path: interaction:Binding >prep_between themet,e2: args2Role-mention-ngram: mediated by thetSe1: trigger-arg-path: interaction >prep_between [lemma='tax1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='tax1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: CONTROLLED istZe1: trigger-arg-path: interaction >prep_between [lemma='nucleoporin'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass Generic_eventte1: incoming: agent [lemma='motif'] >nn [lemma='zinc-finger'] Familyt e2: ents2Label-mention-ngram: istre2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventte2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controllert5e2: args2Role-mention-ngram: aminoterminal CONTROLLERtVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='tax1'] themet`e1: trigger-arg-path: interaction >prep_between [lemma='nucleoporin'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: mediated bytde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between theme:Gene_or_gene_productt3anaphor-basic: args2Role-mention-ngram: interactiontSe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass controlled:Generic_eventtXe2: trigger-arg-path: Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventt1e1: trigger-arg-path: Binding >prep_between themete1: trigger: interactiont6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT andtae2: trigger-arg-path: mediated:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventtEe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn controllert*e2: args2Role-mention-ngram: aminoterminaltEe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass controlledtte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nucleoporin'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: thet>e1: ents2Label-mention-ngram: between GENE_OR_GENE_PRODUCT andt(e2: args2Role-mention-ngram: mediated bytFe1: ents2Label-mention-ngram: interaction between GENE_OR_GENE_PRODUCTt]e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nucleoporin'] themet#anaphor-basic: trigger: interactiont^e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass [lemma='interaction'] Generic_eventt anaphor-basic: all-labels: EventtLe1: trigger-arg-path: interaction:Binding >prep_between Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nucleoporin'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: thet[e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass [lemma='interaction'] controlledt`e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn controller:Familytoe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='interaction'] controlledte2: args2Role-mention-ngram: ist%e1: ents2Label-mention-ngram: and thet&anaphor-basic: all-labels: SimpleEventtge2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='motif'] >nn [lemma='zinc-finger'] Familytsortest-path-dist: 2t0e1: args2Role-mention-ngram: interaction betweent+e2: args2Role-mention-ngram: is mediated byt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and thet$e1: args2Role-mention-ngram: and thet,e2: ents2Label-mention-ngram: is mediated bytue2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controller:FamilytMe2: trigger-arg-path: Positive_regulation >nsubjpass controlled:Generic_eventt)e1: ents2Label-mention-ngram: interactiontje2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] Familyt*e1: args2Role-mention-ngram: and the THEMEt
ante: prevt+e2: ents2Label-mention-ngram: aminoterminaltie2: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass [lemma='interaction'] controlled:Generic_eventtGe1: trigger-arg-path: Binding >prep_between [lemma='nucleoporin'] themetce2: trigger-arg-path: Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventt!e1: ents2Label-mention-ngram: andt1e2: args2Role-mention-ngram: by the aminoterminaltne2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='motif'] >nn [lemma='zinc-finger'] controllertbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='nucleoporin'] Gene_or_gene_productt e2: args2Role-mention-ngram: thete2: label: Positive_regulationt^e2: trigger-arg-path: mediated:Positive_regulation >nsubjpass [lemma='interaction'] controlledt5e1: trigger-arg-path: interaction >prep_between themet$e1: args2Role-mention-ngram: betweent7e1-label: Generic_event + e2-label: Positive_regulationte2: CONTROLLER: 2t&e1: args2Role-mention-ngram: THEME andt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between Gene_or_gene_productt%e2: args2Role-mention-ngram: mediatedt4e2: trigger-arg-path: mediated >agent >nn controllert3e2: args2Role-mention-ngram: CONTROLLED is mediatedtYe1: trigger-arg-path: interaction >prep_between [lemma='tax1'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: by the aminoterminalt*e1: args2Role-mention-ngram: between THEMEtLe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn controller:FamilytZe2: trigger-arg-path: mediated >agent [lemma='motif'] >nn [lemma='zinc-finger'] controllert.e2: args2Role-mention-ngram: the aminoterminalt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activationtIe1: trigger-arg-path: Positive_regulation >nsubj >nn Gene_or_gene_producttre1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] Gene_or_gene_producttge1: trigger-arg-path: involves >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER activationte2: trigger: phosphorylationtQe2: trigger-arg-path: Positive_regulation prep_by >nn Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by >nn Gene_or_gene_productt4e1: trigger-arg-path: involves >nsubj >nn controllert?e2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] Gene_or_gene_producttqe1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controllertae2: trigger-arg-path: phosphorylation:Positive_regulation prep_by >nn Gene_or_gene_producttCe2: trigger-arg-path: phosphorylation prep_by >nn controllert%e1: args2Role-mention-ngram: involvestUe2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by >nn controllert1e1: ents2Label-mention-ngram: activation involvest;e1: args2Role-mention-ngram: activation involves CONTROLLEDt=e1-label: Positive_regulation + e2-label: Positive_regulationt;e1: args2Role-mention-ngram: CONTROLLER activation involvest~e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controllertAe1: ents2Label-mention-ngram: activation involves phosphorylationtWe2: trigger-arg-path: phosphorylation:Positive_regulation prep_by >nn controllert&e1: ents2Label-mention-ngram: involvest e1: ents2Label-mention-ngram: byttrigger-to-trigger-path: e1:involves:Positive_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationt`shortest-path: dobj [lemma='phosphorylation']t>e1: trigger-arg-path: involves >nsubj >nn Gene_or_gene_productt}e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: of SHARED byt'e1: ents2Label-mention-ngram: of SHAREDt?e2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: the SHAREDt+e2: args2Role-mention-ngram: the CONTROLLERt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controllertGe2: trigger-arg-path: Positive_regulation prep_by >nn controllertRe1: trigger-arg-path: involves:Positive_regulation >nsubj >nn Gene_or_gene_productt9e1: ents2Label-mention-ngram: involves phosphorylation oft.e2: args2Role-mention-ngram: by the CONTROLLERt*e2: ents2Label-mention-ngram: of SHARED byt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controllert*e2: args2Role-mention-ngram: CONTROLLED bytZe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >nn controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: involves phosphorylationt+e2: ents2Label-mention-ngram: SHARED by thet7e2: ents2Label-mention-ngram: phosphorylation of SHAREDtxe2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controllert]e1: trigger-arg-path: involves:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controllert0e1: args2Role-mention-ngram: activation involvest{e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj >nn controller:Gene_or_gene_productte1: trigger: involvestIe1: trigger-arg-path: involves >nsubj >nn controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: SHARED byt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: by the SHAREDt?e2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt]e1: trigger-arg-path: involves >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controllert?e1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controller:Gene_or_gene_producttle2: trigger-arg-path: phosphorylation:Positive_regulation prep_by >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] Gene_or_gene_productt|e2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controllert?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by >nn controllertshortest-path: dobjte2: CONTROLLER: 3t7e1: ents2Label-mention-ngram: phosphorylation of SHAREDt(e1: ents2Label-mention-ngram: activationtXe2: trigger-arg-path: phosphorylation prep_by >nn controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: phosphorylationt0e1: args2Role-mention-ngram: involves CONTROLLEDt?e1: trigger-arg-path: Positive_regulation >nsubj >nn controllert0e1: ents2Label-mention-ngram: phosphorylation oftsortest-path-dist: 3t.e2: args2Role-mention-ngram: CONTROLLED by thetne1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttetrigger-to-trigger-path: e1:involves:Positive_regulation >dobj e2:phosphorylation:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] Gene_or_gene_producttMe2: trigger-arg-path: phosphorylation prep_by >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: activationt+e1: ents2Label-mention-ngram: SHARED by thet?e2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='ikappab'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='ikappab'] controller:Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activation involvestre1: trigger-arg-path: involves >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >nn Gene_or_gene_productt e1: ents2Label-mention-ngram: oft'e1: ents2Label-mention-ngram: SHARED byt\e2: trigger-arg-path: Positive_regulation prep_by >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: by the SHAREDtne1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controllert(e2: ents2Label-mention-ngram: the SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >nn controllertEe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >nn controllert_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by >nn Gene_or_gene_productt e2: ents2Label-mention-ngram: oftHe1: trigger-arg-path: involves:Positive_regulation >nsubj >nn controllerthe1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] controllert0e2: ents2Label-mention-ngram: phosphorylation oftxe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >nn [lemma='nf-kappab'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: by thet'e2: ents2Label-mention-ngram: of SHAREDtOe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >nn Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by >nn controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: phosphorylationt[e2: trigger-arg-path: represses:Negative_activation dobj [lemma='transactivation'] >nn [lemma='tax1'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=repress prep_with [lemma='tax1'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='tax1'] themetQe1: trigger-arg-path: Binding >nsubj [lemma='suv39h1'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation nsubj [lemma='suv39h1'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj >nn controlledt>e1: trigger-arg-path: interacts >nsubj [lemma='suv39h1'] themet|e2: trigger-arg-path: Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlled:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation prep_with [lemma='tax1'] themetDe2: trigger-arg-path: represses conj_and e2:represses:Negative_activationt[e1: trigger-arg-path: interacts:Binding >nsubj [lemma='suv39h1'] theme:Gene_or_gene_productt(shortest-path: dobj >nn controlledt-e2: ents2Label-mention-ngram: with SHARED andtXe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation prep_with [lemma='tax1'] themet\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='tax1'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: and repressest1e2: trigger-arg-path: represses nsubj [lemma='suv39h1'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tax1'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED interacts witht)e1: ents2Label-mention-ngram: with SHAREDt,e2: ents2Label-mention-ngram: interacts withtqe2: trigger-arg-path: represses:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlledtXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tax1'] themetSe1: trigger-arg-path: interacts >nsubj [lemma='suv39h1'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='suv39h1'] theme:Gene_or_gene_producttge2: trigger-arg-path: Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlledt5e2: args2Role-mention-ngram: and represses CONTROLLEDtRe2: trigger-arg-path: represses:Negative_activation >dobj >nn Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tax1'] theme:Gene_or_gene_producttge2: trigger-arg-path: represses >dobj [lemma='transactivation'] >nn [lemma='tax1'] Gene_or_gene_productt>e2: trigger-arg-path: Negative_activation >dobj >nn controlledtke2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation dobj >nn controlled:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj >nn controlled:Gene_or_gene_producttMe1: trigger-arg-path: interacts >nsubj [lemma='suv39h1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='suv39h1'] themet;e2: trigger-arg-path: Negative_activation nsubj [lemma='suv39h1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlledtEe2: trigger-arg-path: represses:Negative_activation nsubj [lemma='suv39h1'] themetnsubj [lemma='suv39h1'] themet>e2: trigger-arg-path: Negative_activation nsubj [lemma='suv39h1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Negative_activation >dobj >nn controlled:Gene_or_gene_producttre2: trigger-arg-path: represses >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlled:Gene_or_gene_producttNe2: trigger-arg-path: Negative_activation prep_with [lemma='tax1'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Negative_activation >dobj >nn Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='transactivation'] >nn [lemma='tax1'] Gene_or_gene_productt]e2: trigger-arg-path: represses >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlledt?e2: trigger-arg-path: represses:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlled:Gene_or_gene_productt4e2: trigger-arg-path: represses dobj >nn Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=repress >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlled:Gene_or_gene_productt3e2: ents2Label-mention-ngram: interacts with SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED interactst_e2: trigger-arg-path: lemmatizedTrigger=repress prep_with [lemma='tax1'] theme:Gene_or_gene_producttQe2: trigger-arg-path: Negative_activation dobj >nn controlledt{e2: trigger-arg-path: represses:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='tax1'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: interactst"e2: ents2Label-mention-ngram: witht?e2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='transactivation'] >nn [lemma='tax1'] controlled:Gene_or_gene_producttXe2: trigger-arg-path: represses:Negative_activation prep_with [lemma='tax1'] themetDe2: trigger-arg-path: lemmatizedTrigger=repress >dobj >nn controlledtIe2: trigger-arg-path: represses >dobj >nn controlled:Gene_or_gene_producttPe2: trigger-arg-path: represses:Negative_activation prep_with [lemma='tax1'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=repress e2: trigger-arg-path: represses >dobj >nn Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=repress prep_with [lemma='tax1'] Gene_or_gene_producttjtrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='repress'] e2:represses:Negative_activationt`e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation prep_with [lemma='tax1'] Gene_or_gene_productt]e2: trigger-arg-path: represses:Negative_activation >dobj >nn controlled:Gene_or_gene_producttshortest-path: nsubj [lemma='suv39h1'] Gene_or_gene_productte2: CONTROLLED: 2tme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tax1'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >nsubj [lemma='suv39h1'] themetoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='relb'] theme:Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT then phosphorylatest/interceding-token ngrams: subsequent processingt,e1: args2Role-mention-ngram: then CONTROLLEDtKe2: trigger-arg-path: complex >nn [lemma='relb'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: C-terminalt interceding-token ngrams: of thete1: incoming: nsubj Gene_or_gene_productt.e2: args2Role-mention-ngram: and THEME complext:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT complextHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p100'] themet$interceding-token ngrams: subsequenttinterceding-token ngrams: thetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn Gene_or_gene_productt,e2: args2Role-mention-ngram: THEME and THEMEtAe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn themet'e1: ents2Label-mention-ngram: region oft[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj controllert3e1: ents2Label-mention-ngram: the C-terminal regiont@e1: trigger-arg-path: phosphorylates >nsubj Gene_or_gene_productt/interceding-token ngrams: leading to subsequenttPe1: trigger-arg-path: Positive_regulation >nsubj controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME complext1e1-label: Positive_regulation + e2-label: Bindingte2: all-labels: SimpleEventt6e2: trigger-arg-path: Binding >nn [lemma='p100'] themet+interceding-token ngrams: processing of thetEe2: trigger-arg-path: Binding >nn [lemma='relb'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p100'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj Gene_or_gene_producttxtrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj >prep_of >vmod >prep_to >prep_of e2:complex:Bindingtne1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikkalpha'] controllertSe1: trigger-arg-path: phosphorylates >nsubj [lemma='ikkalpha'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT complextge1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikkalpha'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='relb'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: C-terminal region oftNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='p100'] themet5e1: ents2Label-mention-ngram: then phosphorylates thet&e2: args2Role-mention-ngram: and THEMEtinterceding-token ngrams: totsortest-path-dist: 7tHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='relb'] themetnn theme:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='p100'] Gene_or_gene_productt6e1: trigger-arg-path: phosphorylates >nsubj controllertEinterceding-tokens-full-span: leading to subsequent processing of thet6e2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCTt6e2: trigger-arg-path: Binding >nn Gene_or_gene_productt1e1: ents2Label-mention-ngram: then phosphorylatest%e2: ents2Label-mention-ngram: complextKe1: trigger-arg-path: phosphorylates >nsubj controller:Gene_or_gene_productt'e2: trigger-arg-path: Binding >nn themet2interceding-token ngrams: to subsequent processingt2e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCTt=e2: ents2Label-mention-ngram: SHARED and GENE_OR_GENE_PRODUCTtxe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikkalpha'] Gene_or_gene_productt!e1: args2Role-mention-ngram: thentDe2: trigger-arg-path: complex:Binding >nn theme:Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='relb'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='relb'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p100'] theme:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='relb'] themet/e1: ents2Label-mention-ngram: C-terminal regiontPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p100'] themet$interceding-token ngrams: leading totpe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: phosphorylates the C-terminalt^e1: trigger-arg-path: phosphorylates >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_producttce1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='relb'] themetnn theme:Gene_or_gene_producttTe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj controllertSe2: trigger-arg-path: complex:Binding >nn [lemma='p100'] theme:Gene_or_gene_productt@shortest-path: dobj >prep_of >vmod >prep_to >prep_of >nnt2interceding-token ngrams: subsequent processing oft'interceding-token ngrams: processing oftPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='p100'] Gene_or_gene_productte2: THEME: 1t6e2: trigger-arg-path: complex >nn Gene_or_gene_producttJe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj controllert_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p100'] Gene_or_gene_productttrigger-dist: 5tKe2: trigger-arg-path: complex >nn [lemma='p100'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='p100'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p100'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: regiontNe2: trigger-arg-path: lemmatizedTrigger=complex >nn theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: the C-terminalt/e2: trigger-arg-path: complex:Binding >nn themete2: trigger: complext]e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikkalpha'] controllert7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT thente2: label: Bindingt7e1: args2Role-mention-ngram: CONTROLLER then CONTROLLEDtKe2: trigger-arg-path: Binding >nn [lemma='p100'] theme:Gene_or_gene_producttIe1: trigger-arg-path: phosphorylates >nsubj [lemma='ikkalpha'] controllert$e2: args2Role-mention-ngram: complext$interceding-token ngrams: processingte2: all-labels: Bindingt?shortest-path: dobj [lemma='region'] >prep_of [lemma='p100'] >vmod [lemma='lead'] >prep_to [lemma='processing'] >prep_of [lemma='complex'] >nn [lemma='p100']t"e1: ents2Label-mention-ngram: thent,e1: args2Role-mention-ngram: CONTROLLER thentEe2: trigger-arg-path: Binding >nn [lemma='p100'] Gene_or_gene_productte1: outgoing: >vmodtEe1: trigger-arg-path: Positive_regulation >nsubj Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='relb'] themet;e1: trigger-arg-path: Positive_regulation >nsubj controllertPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='relb'] themet"e2: args2Role-mention-ngram: THEMEtXe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] Gene_or_gene_productt'interceding-token ngrams: to subsequentt\e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='relb'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='relb'] Gene_or_gene_producttre1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_productt9e2: trigger-arg-path: lemmatizedTrigger=complex >nn themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='relb'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn theme:Gene_or_gene_productt!interceding-token ngrams: leadingtZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] controllert_e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj [lemma='region'] >prep_of [lemma='p100'] >vmod [lemma='lead'] >prep_to [lemma='processing'] >prep_of [lemma='complex'] e2:complex:Bindingt&e2: args2Role-mention-ngram: THEME andt'e2: trigger-arg-path: complex >nn themet0e1: ents2Label-mention-ngram: phosphorylates thetSe2: trigger-arg-path: complex:Binding >nn [lemma='relb'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: region of SHAREDtce2: trigger-arg-path: Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn themet"e2: args2Role-mention-ngram: boundtce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='gpcr'] controllert1interceding-token ngrams: subunit and facilitatestye1: trigger-arg-path: Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlled:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] theme:Gene_or_gene_producttme2: trigger-arg-path: Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: boundt^e2: trigger-arg-path: bound:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] themet e1: ents2Label-mention-ngram: ant1e1-label: Positive_activation + e2-label: Bindingtle1: trigger-arg-path: induces:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlledt,interceding-token ngrams: Galpha subunit andt`e1: trigger-arg-path: induces:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlledtdobj >nn themet>e1: ents2Label-mention-ngram: exchange of GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlled:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='exchange'] >prep_of [lemma='GDP'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlledtCe1: trigger-arg-path: Positive_activation >dobj >prep_of controlledt@e2: trigger-arg-path: bound >dobj >nn theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of themet3e2: trigger-arg-path: Binding >nsubj >prep_of themet1e2: trigger-arg-path: bound >nsubj >prep_of themetge2: trigger-arg-path: Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] Gene_or_gene_productt'interceding-token ngrams: on the Galphat%interceding-token ngrams: subunit andte1: incoming: ccomp >nsubj >prep_oft\e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of controlledt6interceding-token ngrams: facilitates the dissociationtYtrigger-to-trigger-path: e1:induces:Positive_activation >conj_and >ccomp e2:bound:Bindingt$interceding-token ngrams: GTP on thet#interceding-token ngrams: to GTP onte1: args2Role-mention-ngram: ant interceding-token ngrams: on thetRe2: trigger-arg-path: bound >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] themet+e2: trigger-arg-path: bound >dobj >nn themetVe2: trigger-arg-path: bound >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] themetsortest-path-dist: 4tHe2: trigger-arg-path: bound:Binding >dobj >nn theme:Gene_or_gene_productte1: all-labels: ActivationEventtEe1: trigger-arg-path: Positive_activation >nsubj Gene_or_gene_producttBe2: trigger-arg-path: bound:Binding >dobj >nn Gene_or_gene_productt$interceding-token ngrams: the GalphatBe2: trigger-arg-path: Binding >nsubj >prep_of Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn Gene_or_gene_producttTe1: trigger-arg-path: Positive_activation >nsubj [lemma='gpcr'] Gene_or_gene_producttse2: trigger-arg-path: bound:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttXe1: trigger-arg-path: induces >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlledte1: CONTROLLED: 2t3e2: trigger-arg-path: bound:Binding >dobj >nn themetTe2: trigger-arg-path: Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] themet!interceding-token ngrams: subunitt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of theme:Gene_or_gene_productt,interceding-token ngrams: the Galpha subunitt-interceding-token ngrams: and facilitates thetTe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controllert1e1: ents2Label-mention-ngram: induces an exchangetHe2: trigger-arg-path: Binding >nsubj >prep_of theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='gpcr'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: bound GENE_OR_GENE_PRODUCTt/e1: trigger-arg-path: induces >nsubj controllertre2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] Gene_or_gene_producttoe2: trigger-arg-path: bound:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] theme:Gene_or_gene_productte2: THEME: 2t:e2: trigger-arg-path: bound >dobj >nn Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='gpcr'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: an exchangetdobj >nn Gene_or_gene_productt}trigger-to-trigger-path: e1:induces:Positive_activation >conj_and [lemma='facilitate'] >ccomp [lemma='bind'] e2:bound:Bindingt%e1: ents2Label-mention-ngram: inducestke2: trigger-arg-path: bound >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttushortest-path: ccomp [lemma='bind'] >nsubj [lemma='dissociation'] >prep_of [lemma='gtp']t$e1: args2Role-mention-ngram: inducestKe1: trigger-arg-path: induces:Positive_activation >dobj >prep_of controlledtHe1: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of controlledtie1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of controlled:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Gene_or_gene_productt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT boundte2: trigger: boundtQe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Gene_or_gene_productt)interceding-token ngrams: and facilitatestJe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj Gene_or_gene_producttinterceding-token ngrams: ontYe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:Gene_or_gene_productt interceding-token ngrams: GalphatMe1: trigger-arg-path: Positive_activation >dobj >prep_of Gene_or_gene_productt interceding-token ngrams: GTP ontMe1: trigger-arg-path: induces:Positive_activation >nsubj Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] theme:Gene_or_gene_producttve1: trigger-arg-path: induces:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] Gene_or_gene_producttLe1: trigger-arg-path: induces >dobj >prep_of controlled:Gene_or_gene_producttDe1: trigger-arg-path: induces >nsubj controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: induces antFe2: trigger-arg-path: bound >nsubj >prep_of theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] Gene_or_gene_productt(interceding-token ngrams: Galpha subunitt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducest*e1: args2Role-mention-ngram: of CONTROLLEDtde1: trigger-arg-path: Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlledt,e1: ents2Label-mention-ngram: an exchange oftBe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of themetee2: trigger-arg-path: bound >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] Gene_or_gene_producttXe1: trigger-arg-path: induces:Positive_activation >nsubj controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: exchange oftWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of theme:Gene_or_gene_producttNe2: trigger-arg-path: bound:Binding >nsubj >prep_of theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: an exchangetke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] themet@e2: trigger-arg-path: bound >nsubj >prep_of Gene_or_gene_producttinterceding-token ngrams: andt0e1: args2Role-mention-ngram: induces an exchangetinterceding-token ngrams: GTPt'e1: args2Role-mention-ngram: induces antme1: trigger-arg-path: induces >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlled:Gene_or_gene_producttme2: trigger-arg-path: bound:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] Gene_or_gene_producttHe1: trigger-arg-path: induces >nsubj [lemma='gpcr'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt9e1: trigger-arg-path: induces >nsubj Gene_or_gene_producttZe2: trigger-arg-path: bound:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] themetie2: trigger-arg-path: Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] theme:Gene_or_gene_productt5e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCTt;e1: trigger-arg-path: Positive_activation >nsubj controllertXe2: trigger-arg-path: Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] themetPe1: trigger-arg-path: Positive_activation >nsubj controller:Gene_or_gene_productt-e2: trigger-arg-path: Binding >dobj >nn themetUe1: trigger-arg-path: induces:Positive_activation >dobj >prep_of Gene_or_gene_productt3e1: args2Role-mention-ngram: exchange of CONTROLLEDtne1: trigger-arg-path: Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of Gene_or_gene_productt9e2: trigger-arg-path: bound:Binding >nsubj >prep_of themet(e2: args2Role-mention-ngram: bound THEMEt~e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] Gene_or_gene_productt^interceding-tokens-full-span: to GTP on the Galpha subunit and facilitates the dissociation oft*interceding-token ngrams: the dissociationtoe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] themet#e1: all-labels: Positive_activationtHe2: trigger-arg-path: bound:Binding >nsubj >prep_of Gene_or_gene_producttie2: trigger-arg-path: bound:Binding >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] themetBe2: trigger-arg-path: Binding >dobj >nn theme:Gene_or_gene_producttSe1: trigger-arg-path: induces >nsubj [lemma='gpcr'] controller:Gene_or_gene_producttbe1: trigger-arg-path: induces >dobj [lemma='exchange'] >prep_of [lemma='GDP'] Gene_or_gene_productt?e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlled:Gene_or_gene_producttge2: trigger-arg-path: bound >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] theme:Gene_or_gene_producttAe1: trigger-arg-path: induces >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='exchange'] >prep_of [lemma='GDP'] Gene_or_gene_productte1: trigger: inducestXe1: trigger-arg-path: Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt)interceding-token ngrams: facilitates thet(e1: args2Role-mention-ngram: exchange oft_e1: trigger-arg-path: Positive_activation >nsubj [lemma='gpcr'] controller:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] themet&interceding-token ngrams: dissociationtge1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='gpcr'] controller:Gene_or_gene_productt>e1: trigger-arg-path: induces >nsubj [lemma='gpcr'] controllerte1: args2Role-mention-ngram: oft%e1: args2Role-mention-ngram: exchangetMe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound GENE_OR_GENE_PRODUCTt/e1: args2Role-mention-ngram: CONTROLLER inducest%interceding-token ngrams: facilitatest(e2: args2Role-mention-ngram: THEME boundtUe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj Gene_or_gene_productt\e1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='gpcr'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='gpcr'] controllertRe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='gpcr'] controllert.e2: args2Role-mention-ngram: THEME bound THEMEtve2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='dissociation'] >prep_of [lemma='gtp'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: exchanget-interceding-token ngrams: the dissociation oft)interceding-token ngrams: dissociation oft=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces ante1: label: Positive_activationt~e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='exchange'] >prep_of [lemma='GDP'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: Positive_activation >nsubj [lemma='gpcr'] controllertme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='gpcr'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='gpcr'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of Gene_or_gene_producttae2: trigger-arg-path: bound >dobj [lemma='subunit'] >nn [lemma='gbetagamma'] Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER induces antCe1: trigger-arg-path: induces:Positive_activation >nsubj controllert7e1: trigger-arg-path: induces >dobj >prep_of controlledtYe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of Gene_or_gene_productt interceding-token ngrams: to GTPtfe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controller:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='hypophosphorylation'] Phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationtse1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controllertbe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] Phosphorylationt4e1: args2Role-mention-ngram: CONTROLLER inhibits p53t)e1: args2Role-mention-ngram: inhibits p53txe1: trigger-arg-path: Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] Gene_or_gene_productt@e1: ents2Label-mention-ngram: induced SHARED hypophosphorylationt?e2: trigger-arg-path: Negative_regulation >dobj PhosphorylationtRe2: trigger-arg-path: Negative_regulation >nsubj >rcmod >dobj Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controlledtbe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] Phosphorylationt8e1: trigger-arg-path: induced >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=induce >dobj controlledtRe1: trigger-arg-path: induced:Positive_regulation >dobj controlled:Phosphorylationtpe2: trigger-arg-path: induced:Negative_regulation >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationtae2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >rcmod >dobj controllertBe1: trigger-arg-path: induced >nsubj >prep_of Gene_or_gene_productt]e1: trigger-arg-path: Positive_regulation >dobj [lemma='hypophosphorylation'] PhosphorylationtXe2: trigger-arg-path: Negative_regulation >dobj [lemma='hypophosphorylation'] controlledt?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationtme1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationt!e1: ents2Label-mention-ngram: p53tbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >rcmod >dobj controller:Gene_or_gene_producttBe1: trigger-arg-path: induced:Positive_regulation >dobj controlledt1e2: ents2Label-mention-ngram: hypophosphorylationt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controller:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of Gene_or_gene_productt,e1: ents2Label-mention-ngram: induced SHAREDtqe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj [lemma='hypophosphorylation'] controlledt0e1: ents2Label-mention-ngram: p53 induced SHAREDtke2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >rcmod >dobj Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >dobj Phosphorylationt$shortest-path: rcmod >dobjt?e2: trigger-arg-path: induced >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controller:Gene_or_gene_producttue2: trigger-arg-path: induced >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controllertDe1: trigger-arg-path: lemmatizedTrigger=induce >dobj PhosphorylationtXe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj Phosphorylationtee1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='hypophosphorylation'] Phosphorylationtpe1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationtnsubj >rcmod >dobj controllert?e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controller:Gene_or_gene_producttle1: trigger-arg-path: induced >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controller:Gene_or_gene_producttne1: trigger-arg-path: Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controllertIe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of controllert]shortest-path: rcmod [lemma='inhibit'] >dobj [lemma='p53']t3e1: trigger-arg-path: induced >dobj Phosphorylationt2e1: ents2Label-mention-ngram: inhibits p53 inducedte2: trigger-arg-path: induced >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: inhibits p53tSe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj controlledt,e2: ents2Label-mention-ngram: induced SHAREDtLe2: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >rcmod >dobj Gene_or_gene_productt3e2: trigger-arg-path: induced >dobj PhosphorylationtJe2: trigger-arg-path: Negative_regulation >dobj controlled:PhosphorylationtJe1: trigger-arg-path: Positive_regulation >dobj controlled:PhosphorylationtMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >rcmod >dobj controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] Gene_or_gene_productt\e2: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibits p53t?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] Gene_or_gene_productt/e1: args2Role-mention-ngram: induced CONTROLLEDt%e2: ents2Label-mention-ngram: inducedt.e2: trigger-arg-path: induced >dobj controlledt\e1: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationt:e2: args2Role-mention-ngram: CONTROLLER induced CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controllert8e1: ents2Label-mention-ngram: SHARED hypophosphorylationtPe2: trigger-arg-path: induced:Negative_regulation >nsubj >rcmod >dobj controllert>e1: trigger-arg-path: induced >dobj controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controller:Gene_or_gene_producttXe1: trigger-arg-path: Positive_regulation >dobj [lemma='hypophosphorylation'] controlledtMe1: trigger-arg-path: induced >nsubj >prep_of controller:Gene_or_gene_productte2: label: Negative_regulationtDe2: trigger-arg-path: lemmatizedTrigger=induce >dobj Phosphorylationt$e1: args2Role-mention-ngram: inducedt%e1: ents2Label-mention-ngram: inducedt1e1: args2Role-mention-ngram: inhibits p53 inducedtae1: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER inducedtqe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='hypophosphorylation'] controlledtwe1: trigger-arg-path: induced >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controller:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] Gene_or_gene_productt e1: args2Role-mention-ngram: p53tve2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj [lemma='hypophosphorylation'] PhosphorylationtHe2: trigger-arg-path: Negative_regulation >nsubj >rcmod >dobj controllertRe2: trigger-arg-path: induced:Negative_regulation >dobj controlled:Phosphorylationtee2: trigger-arg-path: induced:Negative_regulation >dobj [lemma='hypophosphorylation'] Phosphorylationtce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] Gene_or_gene_producttLe1: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] controlledtve2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >rcmod >dobj controller:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=induce >dobj controlled:Phosphorylationt^e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of controller:Gene_or_gene_productt`e1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='hypophosphorylation'] controlledtee2: trigger-arg-path: induced:Negative_regulation >nsubj >rcmod >dobj controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: p53 induced CONTROLLEDtAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced SHAREDtZe2: trigger-arg-path: induced:Negative_regulation >nsubj >rcmod >dobj Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] controlledtOe2: trigger-arg-path: lemmatizedTrigger=induce >dobj controlled:PhosphorylationtFe2: trigger-arg-path: induced >nsubj >rcmod >dobj Gene_or_gene_producttDe1: trigger-arg-path: Positive_regulation >nsubj >prep_of controllert:e2: trigger-arg-path: Negative_regulation >dobj controlledt#e2: all-labels: Negative_regulationte2: trigger: inducedt)e1: ents2Label-mention-ngram: p53 inducedtce2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj controlled:Phosphorylationt$e2: args2Role-mention-ngram: inducedt?e2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] Gene_or_gene_productt:e1: trigger-arg-path: Positive_regulation >dobj controlledtYe1: trigger-arg-path: Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controllert?e2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controllert1e1: ents2Label-mention-ngram: hypophosphorylationt8e2: ents2Label-mention-ngram: SHARED hypophosphorylationt?e2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controller:Gene_or_gene_producttQe2: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] PhosphorylationtBe2: trigger-arg-path: induced:Negative_regulation >dobj controlledthe2: trigger-arg-path: Negative_regulation >dobj [lemma='hypophosphorylation'] controlled:PhosphorylationtVe1: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controllert`e2: trigger-arg-path: induced:Negative_regulation >dobj [lemma='hypophosphorylation'] controlledt.e1: trigger-arg-path: induced >dobj controlledthe1: trigger-arg-path: Positive_regulation >dobj [lemma='hypophosphorylation'] controlled:Phosphorylationt>e2: trigger-arg-path: induced >dobj controlled:PhosphorylationtNe1: trigger-arg-path: Positive_regulation >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controller:Gene_or_gene_producttQe2: trigger-arg-path: induced >nsubj >rcmod >dobj controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: induced CONTROLLEDt]e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='hypophosphorylation'] controlledt?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >dobj PhosphorylationtGe2: trigger-arg-path: induced:Negative_regulation >dobj Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='downregulation'] >rcmod [lemma='inhibit'] >dobj [lemma='p53'] controllert:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducedtLe1: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of controllert]e2: trigger-arg-path: Negative_regulation >dobj [lemma='hypophosphorylation'] Phosphorylationt=e1-label: Positive_regulation + e2-label: Negative_regulationt?e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] Gene_or_gene_productt@e2: ents2Label-mention-ngram: induced SHARED hypophosphorylationte1: trigger: inducedt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibitst%e1: args2Role-mention-ngram: inhibitstGe1: trigger-arg-path: induced:Positive_regulation >dobj Phosphorylationt]e2: trigger-arg-path: Negative_regulation >nsubj >rcmod >dobj controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of controllert0e1: args2Role-mention-ngram: CONTROLLER inhibitstve1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controllertQe1: trigger-arg-path: induced >dobj [lemma='hypophosphorylation'] Phosphorylationt&e1: ents2Label-mention-ngram: inhibitst(e1: args2Role-mention-ngram: p53 inducedtbe1: trigger-arg-path: induced >nsubj [lemma='downregulation'] >prep_of [lemma='ppp1ca'] controllert2e2: trigger-arg-path: stimulated >nsubj controllertQe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj controller:Simple_chemicalt^e2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_producttUe2: trigger-arg-path: stimulated >nsubj [lemma='egf'] controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: stimulated phosphorylationt8e1: ents2Label-mention-ngram: prevented constitutive andtWe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj controllertTe2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='egf'] controllert.e1: ents2Label-mention-ngram: constitutive andtae2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj Gene_or_gene_producttJe2: trigger-arg-path: stimulated >nsubj [lemma='egf'] Gene_or_gene_productt1e1: trigger-arg-path: prevented >nsubj controllertPe2: trigger-arg-path: Positive_regulation >nsubj controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL preventedtee2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='egf'] controllert?e2: ents2Label-mention-ngram: SHARED stimulated phosphorylationtCe1: trigger-arg-path: prevented >nsubj [lemma='filipin'] controllertXe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj controller:Gene_or_gene_producttPe2: trigger-arg-path: stimulated:Positive_regulation >nsubj Gene_or_gene_productt-e1: ents2Label-mention-ngram: SIMPLE_CHEMICALt(e1: ents2Label-mention-ngram: and SHAREDt@e2: trigger-arg-path: stimulated >nsubj [lemma='egf'] controllertbtrigger-to-trigger-path: e1:prevented:Negative_regulation >ccomp e2:stimulated:Positive_regulationt5e1: ents2Label-mention-ngram: constitutive and SHAREDtSe1: trigger-arg-path: prevented >nsubj [lemma='filipin'] controller:Simple_chemicaltIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] controllert=e1-label: Negative_regulation + e2-label: Positive_regulationt6e1: trigger-arg-path: prevented >nsubj Simple_chemicalt;e2: ents2Label-mention-ngram: stimulated phosphorylation oftFe2: trigger-arg-path: stimulated:Positive_regulation >nsubj controllertRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='filipin'] Simple_chemicaltge1: trigger-arg-path: prevented:Negative_regulation >nsubj [lemma='filipin'] controller:Simple_chemicalt[e2: trigger-arg-path: stimulated:Positive_regulation >nsubj controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: and SHARED stimulatedt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj controller:Simple_chemicalt-e1: args2Role-mention-ngram: constitutive andtDe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL prevented constitutivetQe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='egf'] controllert8e1: args2Role-mention-ngram: constitutive and CONTROLLEDtSe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='filipin'] controllert)e1: args2Role-mention-ngram: constitutivet3e1: args2Role-mention-ngram: prevented constitutivetoe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt@e1: trigger-arg-path: Negative_regulation >nsubj Simple_chemicalt]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='filipin'] controller:Simple_chemicalt;e1: ents2Label-mention-ngram: stimulated phosphorylation oftGe2: trigger-arg-path: stimulated >nsubj controller:Gene_or_gene_producttEe2: trigger-arg-path: Positive_regulation >nsubj Gene_or_gene_productt>e1: args2Role-mention-ngram: CONTROLLER prevented constitutivet/e1: ents2Label-mention-ngram: SHARED stimulatedte1: trigger: preventedt4e1: ents2Label-mention-ngram: prevented constitutivetfe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='egf'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: stimulatedtCe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj controllert=e2: args2Role-mention-ngram: CONTROLLER stimulated CONTROLLEDtKe1: trigger-arg-path: Negative_regulation >nsubj controller:Simple_chemicaltXe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='filipin'] Simple_chemicaltWe1: trigger-arg-path: prevented:Negative_regulation >nsubj [lemma='filipin'] controllerte2: trigger: stimulatedt8e1: ents2Label-mention-ngram: stimulated phosphorylationt'e2: args2Role-mention-ngram: stimulatedt[e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='egf'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='filipin'] controllertZe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj controller:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj Simple_chemicalt;e1: trigger-arg-path: Negative_regulation >nsubj controllert#e1: all-labels: Negative_regulationt&e1: args2Role-mention-ngram: preventedt+e1: args2Role-mention-ngram: and CONTROLLEDtJe1: trigger-arg-path: prevented:Negative_regulation >nsubj Simple_chemicalt\e1: trigger-arg-path: prevented:Negative_regulation >nsubj [lemma='filipin'] Simple_chemicalt(e1: ents2Label-mention-ngram: stimulatedtEe1: trigger-arg-path: prevented:Negative_regulation >nsubj controllert;e2: trigger-arg-path: Positive_regulation >nsubj controllert#shortest-path: ccomp >nsubjtMe1: trigger-arg-path: Negative_regulation >nsubj [lemma='filipin'] controllertHe1: trigger-arg-path: prevented >nsubj [lemma='filipin'] Simple_chemicaltwe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='filipin'] controller:Simple_chemicaltAe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj controllertie2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: SHARED stimulatedtce1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='filipin'] controller:Simple_chemicaltSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt2e2: args2Role-mention-ngram: stimulated CONTROLLEDt2e2: args2Role-mention-ngram: CONTROLLER stimulatedte1: label: Negative_regulationtUe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj controllert*e1: ents2Label-mention-ngram: constitutivetWshortest-path: ccomp [lemma='stimulate'] >nsubj [lemma='egf']tAe1: trigger-arg-path: prevented >nsubj controller:Simple_chemicaltUe1: trigger-arg-path: prevented:Negative_regulation >nsubj controller:Simple_chemicalt?e1: ents2Label-mention-ngram: SHARED stimulated phosphorylationtle1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='filipin'] Simple_chemicalt1e1: args2Role-mention-ngram: CONTROLLER preventedt'e1: ents2Label-mention-ngram: preventedtMe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj Gene_or_gene_producttnsubj Gene_or_gene_productt7e1: args2Role-mention-ngram: prevented constitutive andtvtrigger-to-trigger-path: e1:prevented:Negative_regulation >ccomp [lemma='stimulate'] e2:stimulated:Positive_regulationtze2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_to [lemma='c-src'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_to [lemma='c-src'] theme:Gene_or_gene_productt6e2: trigger-arg-path: bind >dobj [lemma='v-src'] themetAe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj themetPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Generic_entityt&e2: ents2Label-mention-ngram: will nott@trigger-to-trigger-path: e1:binds:Binding >advcl e2:bind:BindingtFe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] themetJe1: trigger-arg-path: binds:Binding >nsubj [lemma='caveolin'] theme:FamilytCe1: trigger-arg-path: binds:Binding >nsubj [lemma='caveolin'] themet9e2: trigger-arg-path: Binding >nsubj theme:Generic_entitytNshortest-path: advcl [lemma='bind'] >nsubj [lemma='it']t1e1: trigger-arg-path: binds:Binding >nsubj Familyte2: trigger: bindtIe2: ents2Label-mention-ngram: mutationally activated GENE_OR_GENE_PRODUCTtKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='c-src'] themet%e1-label: Binding + e2-label: Bindingt)e2: ents2Label-mention-ngram: SHARED willtHe2: trigger-arg-path: Binding >dobj [lemma='v-src'] Gene_or_gene_productt@e2: trigger-arg-path: Binding >nsubj [lemma='it'] Generic_entityt7e2: trigger-arg-path: Binding >nsubj [lemma='it'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='v-src'] themet&e2: trigger-arg-path: bind >dobj themetbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='c-src'] Gene_or_gene_productt(e1: trigger-arg-path: binds >nsubj themet*e2: trigger-arg-path: Binding >nsubj themetGe1: trigger-arg-path: binds:Binding >prep_to theme:Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >prep_to Gene_or_gene_productt9e2: trigger-arg-path: Binding >dobj [lemma='v-src'] themetEe2: trigger-arg-path: bind:Binding >nsubj [lemma='it'] Generic_entitytTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='caveolin'] themet*e2: args2Role-mention-ngram: will not bindt!e2: ents2Label-mention-ngram: nottWe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='it'] Generic_entityte2: incoming: nsubj [lemma='caveolin'] themet2e2: args2Role-mention-ngram: not bind mutationallyt+e1: args2Role-mention-ngram: binds to THEMEt(e1: args2Role-mention-ngram: THEME bindstCe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to themet(interceding-tokens-full-span: , althought2e1: trigger-arg-path: binds:Binding >prep_to themet8e2: trigger-arg-path: lemmatizedTrigger=bind >dobj themet_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='v-src'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Generic_entityt?e1: trigger-arg-path: binds >prep_to theme:Gene_or_gene_productt1e1: trigger-arg-path: Binding >nsubj theme:Familyt9e1: trigger-arg-path: binds >prep_to Gene_or_gene_producttnsubj [lemma='caveolin'] FamilytBe1: trigger-arg-path: binds:Binding >prep_to [lemma='c-src'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='it'] theme:Generic_entityt;e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to themet#shortest-path: advcl >nsubjt/e1: trigger-arg-path: binds >nsubj theme:Familyt=e1: trigger-arg-path: Binding >nsubj [lemma='caveolin'] themet3e2: args2Role-mention-ngram: mutationally activatedt e2: args2Role-mention-ngram: nott%e1: args2Role-mention-ngram: to THEMEtBe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj Generic_entityt*e1: ents2Label-mention-ngram: SHARED bindstLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='caveolin'] themet+e2: ents2Label-mention-ngram: will not bindtOe1: trigger-arg-path: binds >prep_to [lemma='c-src'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: willt>e1: trigger-arg-path: Binding >nsubj [lemma='caveolin'] Familyt+e1: trigger-arg-path: Binding >nsubj FamilytEe2: trigger-arg-path: bind >dobj [lemma='v-src'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='caveolin'] theme:Familyt%e1: args2Role-mention-ngram: binds tot]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='v-src'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='v-src'] Gene_or_gene_productt%e2: args2Role-mention-ngram: not bindtinterceding-token ngrams: ,t*e2: ents2Label-mention-ngram: mutationallyt-e1: ents2Label-mention-ngram: SHARED binds totHe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='v-src'] themetnsubj [lemma='it'] themetWe1: trigger-arg-path: binds:Binding >prep_to [lemma='c-src'] theme:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Familyt`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='c-src'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: binds tote1: trigger: bindst9e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj themetUe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] theme:Generic_entitytCe2: trigger-arg-path: bind >nsubj [lemma='it'] theme:Generic_entityt;e1: ents2Label-mention-ngram: binds to GENE_OR_GENE_PRODUCTt9e2: ents2Label-mention-ngram: bind mutationally activatedtprep_to theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='c-src'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME binds tot&e2: ents2Label-mention-ngram: not bindt)e1: trigger-arg-path: binds >nsubj Familyt!e2: args2Role-mention-ngram: bindt0e2: trigger-arg-path: bind >nsubj Generic_entityt'e2: args2Role-mention-ngram: THEME willt/e2: trigger-arg-path: bind:Binding >nsubj themet:e1: trigger-arg-path: binds >prep_to [lemma='c-src'] themetRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to Gene_or_gene_productt4e2: trigger-arg-path: bind >nsubj [lemma='it'] themet$interceding-token ngrams: , althoughtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='caveolin'] FamilytIe1: trigger-arg-path: binds >prep_to [lemma='c-src'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >dobj Gene_or_gene_producttFe2: trigger-arg-path: Binding >nsubj [lemma='it'] theme:Generic_entityt-e2: ents2Label-mention-ngram: SHARED will nottNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='it'] themetee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='v-src'] theme:Gene_or_gene_productt0e1: trigger-arg-path: binds:Binding >nsubj themet.e2: args2Role-mention-ngram: bind mutationallytNe2: trigger-arg-path: Binding >dobj [lemma='v-src'] theme:Gene_or_gene_productt9e2: args2Role-mention-ngram: mutationally activated THEMEtKe2: trigger-arg-path: bind >dobj [lemma='v-src'] theme:Gene_or_gene_productt7e1: trigger-arg-path: binds:Binding >nsubj theme:FamilytGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj Gene_or_gene_productt=e2: trigger-arg-path: bind >nsubj [lemma='it'] Generic_entitytJe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Generic_entitytHe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Familyt=e2: trigger-arg-path: bind:Binding >dobj Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='caveolin'] FamilytKe2: trigger-arg-path: bind:Binding >nsubj [lemma='it'] theme:Generic_entityt3e2: ents2Label-mention-ngram: not bind mutationallyt'e2: ents2Label-mention-ngram: activatedtDe1: trigger-arg-path: binds:Binding >nsubj [lemma='caveolin'] Familyt;e2: trigger-arg-path: bind >dobj theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj Gene_or_gene_producttprep_to [lemma='c-src'] themet6e2: trigger-arg-path: bind >nsubj theme:Generic_entityt5e2: trigger-arg-path: bind >dobj Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='caveolin'] theme:FamilytSe2: trigger-arg-path: bind:Binding >dobj [lemma='v-src'] theme:Gene_or_gene_productt"interceding-token ngrams: althoughtOe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] Generic_entityt4e2: ents2Label-mention-ngram: mutationally activatedt>e2: trigger-arg-path: Binding >dobj theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: activatedtAe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj themetMe2: trigger-arg-path: bind:Binding >dobj [lemma='v-src'] Gene_or_gene_productt>e2: trigger-arg-path: bind:Binding >nsubj theme:Generic_entityt)e2: trigger-arg-path: Binding >dobj themet%e2: args2Role-mention-ngram: will nott e1: ents2Label-mention-ngram: totXe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: bindt,e1: trigger-arg-path: Binding >prep_to themetOtrigger-to-trigger-path: e1:binds:Binding >advcl [lemma='bind'] e2:bind:Bindingt+e2: args2Role-mention-ngram: THEME will nott)e2: args2Role-mention-ngram: mutationallyt/e2: ents2Label-mention-ngram: bind mutationallytCe2: trigger-arg-path: bind:Binding >dobj theme:Gene_or_gene_productt8e2: trigger-arg-path: bind:Binding >nsubj Generic_entityt!e2: args2Role-mention-ngram: willtSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='c-src'] themet@e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj themet;e1: trigger-arg-path: Binding >prep_to Gene_or_gene_producttQe1: trigger-arg-path: binds:Binding >prep_to [lemma='c-src'] Gene_or_gene_productt9e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj themet>e2: trigger-arg-path: bind:Binding >dobj [lemma='v-src'] themet8e2: args2Role-mention-ngram: bind mutationally activatedtAe1: trigger-arg-path: Binding >prep_to theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: bindst:e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj FamilytMe2: trigger-arg-path: lemmatizedTrigger=bind >dobj theme:Gene_or_gene_productt"e1: args2Role-mention-ngram: bindst3e2: trigger-arg-path: Binding >nsubj Generic_entitytDe1: trigger-arg-path: Binding >nsubj [lemma='caveolin'] theme:Familythe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='c-src'] theme:Gene_or_gene_productt'e2: trigger-arg-path: bind >nsubj themet*e1: trigger-arg-path: binds >prep_to themet5e1: ents2Label-mention-ngram: to GENE_OR_GENE_PRODUCTt.e2: trigger-arg-path: bind:Binding >dobj themet,e2: args2Role-mention-ngram: activated THEMEtBe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Familyte1: args2Role-mention-ngram: totBe1: trigger-arg-path: binds >nsubj [lemma='caveolin'] theme:Familytpe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-1'] theme:Gene_or_gene_productt5e2: args2Role-mention-ngram: N-terminus of CONTROLLERt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of theme:Gene_or_gene_producttPe1: trigger-arg-path: binding >prep_of [lemma='caveolin-3'] Gene_or_gene_productt,e2: args2Role-mention-ngram: the cytoplasmict5e1: ents2Label-mention-ngram: or GENE_OR_GENE_PRODUCTtVe1: trigger-arg-path: binding >prep_of [lemma='caveolin-3'] theme:Gene_or_gene_productt>e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of themet^e1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-1'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Positive_regulation >agent >prep_in >prep_of controllert%e1: args2Role-mention-ngram: of THEMEt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-1'] themet?e2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-1'] Gene_or_gene_productte1: trigger: bindingtstrigger-to-trigger-path: e1:interactions:Generic_event prep_of theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-1'] themet;e1: trigger-arg-path: binding >prep_of Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of Gene_or_gene_productt-e2: ents2Label-mention-ngram: residues 82-101tLe2: trigger-arg-path: mediated >agent >prep_in >prep_of Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controllertPe1: trigger-arg-path: binding >prep_of [lemma='caveolin-1'] Gene_or_gene_productt1e2: args2Role-mention-ngram: mediated by residuest5e2: args2Role-mention-ngram: CONTROLLED were mediatedt'e1: args2Role-mention-ngram: binding oft-e2: args2Role-mention-ngram: were mediated byt(e1: ents2Label-mention-ngram: binding oftpe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-3'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-3'] themet,e2: args2Role-mention-ngram: residues 82-101t(e2: ents2Label-mention-ngram: N-terminust?e2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: mediated by residuest/e2: ents2Label-mention-ngram: interactions weretXe1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-3'] Gene_or_gene_productt^e1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-3'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: N-terminust~e2: trigger-arg-path: mediated >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controllertWe2: trigger-arg-path: Positive_regulation >agent >prep_in >prep_of Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-3'] themetFe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of themet,e2: args2Role-mention-ngram: CONTROLLED weret8e2: ents2Label-mention-ngram: interactions were mediatedt?e2: trigger-arg-path: Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_regulation >agent >prep_in >prep_of controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED ortbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-3'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controller:Gene_or_gene_producttAe1: trigger-arg-path: binding >prep_of theme:Gene_or_gene_productt!e2: args2Role-mention-ngram: weret3e2: args2Role-mention-ngram: cytoplasmic N-terminust$anaphor-basic: trigger: interactionst8e2: ents2Label-mention-ngram: the cytoplasmic N-terminustPe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-3'] Gene_or_gene_productt6e2: args2Role-mention-ngram: cytoplasmic N-terminus oftAe1: trigger-arg-path: binding >prep_of [lemma='caveolin-1'] themet$e1: args2Role-mention-ngram: bindingt?e2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controller:Gene_or_gene_producttVe2: trigger-arg-path: mediated:Positive_regulation >agent >prep_in >prep_of controllert(e1: args2Role-mention-ngram: of THEME ortIe1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-1'] themet%e1: args2Role-mention-ngram: or THEMEtCe1: trigger-arg-path: binding:Binding >prep_of Gene_or_gene_productt*e2: args2Role-mention-ngram: 82-101 in thetBe2: trigger-arg-path: mediated >agent >prep_in >prep_of controllert/e1: ents2Label-mention-ngram: binding of SHAREDtXe1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-1'] Gene_or_gene_productt/e2: args2Role-mention-ngram: by residues 82-101t)e2: ents2Label-mention-ngram: cytoplasmict)e2: ents2Label-mention-ngram: by residuest]e2: trigger-arg-path: lemmatizedTrigger=mediate >agent >prep_in >prep_of Gene_or_gene_productt&e2: args2Role-mention-ngram: 82-101 int*e2: args2Role-mention-ngram: were mediatedt?e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controllertagent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: in thetke2: trigger-arg-path: mediated:Positive_regulation >agent >prep_in >prep_of controller:Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-1'] theme:Gene_or_gene_productt7e2: ents2Label-mention-ngram: cytoplasmic N-terminus oftAe1: trigger-arg-path: Binding >prep_of theme:Gene_or_gene_productt$e2: ents2Label-mention-ngram: 82-101t@e2: ents2Label-mention-ngram: N-terminus of GENE_OR_GENE_PRODUCTtbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-1'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_of Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: N-terminus oftAe1: trigger-arg-path: binding >prep_of [lemma='caveolin-3'] themet0e2: ents2Label-mention-ngram: by residues 82-101tIe1: trigger-arg-path: binding:Binding >prep_of theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: bindingt?e2: trigger-arg-path: Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controller:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >prep_in >prep_of controllert e1: ents2Label-mention-ngram: ort0e2: ents2Label-mention-ngram: residues 82-101 int*e2: ents2Label-mention-ngram: interactionstqe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >prep_in >prep_of Gene_or_gene_productte2: outgoing: >numtAe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-1'] themet0e2: ents2Label-mention-ngram: in the cytoplasmict+e2: ents2Label-mention-ngram: were mediatedt-e2: ents2Label-mention-ngram: the cytoplasmict5anaphor-basic: ents2Label-mention-ngram: interactionst+e2: ents2Label-mention-ngram: 82-101 in thet/e2: args2Role-mention-ngram: residues 82-101 int/e2: args2Role-mention-ngram: in the cytoplasmict%e2: args2Role-mention-ngram: residuestUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of Gene_or_gene_productt(e2: args2Role-mention-ngram: by residuest(e2: args2Role-mention-ngram: cytoplasmict,e1: trigger-arg-path: Binding >prep_of themete1: args2Role-mention-ngram: ort4e1: trigger-arg-path: binding:Binding >prep_of themet7e2: args2Role-mention-ngram: the cytoplasmic N-terminust?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controllertatrigger-to-trigger-path: e1:interactions:Generic_event agent >prep_in >prep_of Gene_or_gene_producttAe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-3'] themet-e1: args2Role-mention-ngram: binding of THEMEthe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-1'] theme:Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_of [lemma='caveolin-3'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: weretVe1: trigger-arg-path: binding >prep_of [lemma='caveolin-1'] theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >prep_in >prep_of controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: were mediated byt+e2: ents2Label-mention-ngram: N-terminus oft#e2: args2Role-mention-ngram: 82-101t4anaphor-basic: args2Role-mention-ngram: interactionste2: args2Role-mention-ngram: oft4e2: ents2Label-mention-ngram: cytoplasmic N-terminust+e1: args2Role-mention-ngram: THEME or THEMEtje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='caveolin-3'] Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >prep_in >prep_of controllertWe2: trigger-arg-path: mediated >agent >prep_in >prep_of controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCTthe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='caveolin-3'] theme:Gene_or_gene_producttIe1: trigger-arg-path: binding:Binding >prep_of [lemma='caveolin-3'] themet?e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: residuest*e1: ents2Label-mention-ngram: of SHARED ort?e2: trigger-arg-path: mediated >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] controller:Gene_or_gene_productt,e1: trigger-arg-path: binding >prep_of themet?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='residue'] >prep_in [lemma='n-terminus'] >prep_of [lemma='caveolin-1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: of CONTROLLERt%e1: args2Role-mention-ngram: THEME orthe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >prep_in >prep_of controller:Gene_or_gene_productt#interceding-token ngrams: decreasedtee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='egfr'] controllertinterceding-token ngrams: upont&e2: args2Role-mention-ngram: can stilltinterceding-token ngrams: wast[e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='egfr'] Gene_or_gene_productt/e2: args2Role-mention-ngram: can still activatetNe1: trigger-arg-path: phosphorylation >prep_by controller:Gene_or_gene_producttRe1: trigger-arg-path: Positive_regulation >prep_by controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: phosphorylation bytje2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlled:Gene_or_gene_productt.e1: args2Role-mention-ngram: CONTROLLED by thet+interceding-token ngrams: , suggesting thatt\e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controllert*interceding-token ngrams: upon cholesteroltEe2: trigger-arg-path: activate >nsubj controller:Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='plcgamma'] controlled:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED phosphorylation byt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttSe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='egfr'] controllerte1: args2Role-mention-ngram: byt#e1: args2Role-mention-ngram: by thetke2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Gene_or_gene_productte1: trigger: phosphorylationtDe2: trigger-arg-path: Positive_activation >dobj Gene_or_gene_productt0e2: ents2Label-mention-ngram: can still activatet4e1: ents2Label-mention-ngram: phosphorylation by thetMe2: trigger-arg-path: activate:Positive_activation >dobj Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='plcgamma'] controlled:Gene_or_gene_productt"e2: args2Role-mention-ngram: stillt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by controllert?trigger-to-trigger-path: e1:phosphorylation:Positive_regulation xcomp [lemma='suggest'] >ccomp [lemma='activate'] e2:activate:Positive_activationtfe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='egfr'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttWe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by Gene_or_gene_producttIe2: trigger-arg-path: activate >nsubj [lemma='egfr'] Gene_or_gene_productt e2: args2Role-mention-ngram: cant#e2: ents2Label-mention-ngram: stillt(e2: ents2Label-mention-ngram: SHARED cant"interceding-token ngrams: that thet&interceding-token ngrams: , suggestingt*e1: args2Role-mention-ngram: CONTROLLED bytfe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_producttbe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by controller:Gene_or_gene_producttCe2: trigger-arg-path: activate:Positive_activation >dobj controlledtKe2: trigger-arg-path: lemmatizedTrigger=activate >dobj Gene_or_gene_productt]e1: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] controllert'interceding-token ngrams: not decreasedt4interceding-token ngrams: decreased upon cholesteroltKe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by controllertHe1: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] controllertMe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by controllertTe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='plcgamma'] controlledthe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='plcgamma'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlledt)interceding-token ngrams: suggesting thatt:e2: trigger-arg-path: activate >nsubj Gene_or_gene_productt/e2: trigger-arg-path: activate >dobj controlledtde1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] Gene_or_gene_producttqe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttCe1: trigger-arg-path: phosphorylation >prep_by Gene_or_gene_productt9e1: trigger-arg-path: phosphorylation >prep_by controllert4interceding-token ngrams: upon cholesterol depletiont`e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj Gene_or_gene_productt-interceding-token ngrams: suggesting that thetLe1: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] controllert/interceding-token ngrams: cholesterol depletiont%interceding-token ngrams: cholesterolt%e2: args2Role-mention-ngram: activatetinterceding-token ngrams: thattoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='egfr'] Gene_or_gene_producttxtrigger-to-trigger-path: e1:phosphorylation:Positive_regulation xcomp >ccomp e2:activate:Positive_activationt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by controller:Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >nsubj [lemma='egfr'] controllertOe2: trigger-arg-path: Positive_activation >dobj controlled:Gene_or_gene_productt1interceding-token ngrams: cholesterol depletion ,t$interceding-token ngrams: suggestingt;e2: trigger-arg-path: Positive_activation >nsubj controllertDe2: trigger-arg-path: activate:Positive_activation >nsubj controllert1e2: args2Role-mention-ngram: CONTROLLER can stilltYe2: trigger-arg-path: activate:Positive_activation >nsubj controller:Gene_or_gene_productt2shortest-path: xcomp >ccomp >nsubjt=e1: trigger-arg-path: Positive_regulation >prep_by controllerte2: label: Positive_activationtVe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='plcgamma'] controlledt,e2: ents2Label-mention-ngram: still activatetUe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by Gene_or_gene_productt+e2: args2Role-mention-ngram: still activatet&e2: ents2Label-mention-ngram: activatete2: trigger: activatetxe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_activation >nsubj [lemma='egfr'] Gene_or_gene_productt%interceding-token ngrams: depletion ,t.e1: args2Role-mention-ngram: by the CONTROLLERt_e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj Gene_or_gene_productt:e2: trigger-arg-path: Positive_activation >dobj controlledt(interceding-token ngrams: decreased upontinterceding-token ngrams: nottGe1: trigger-arg-path: Positive_regulation >prep_by Gene_or_gene_productt+e1: args2Role-mention-ngram: the CONTROLLERt]e2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='egfr'] Gene_or_gene_producttWe2: trigger-arg-path: Positive_activation >dobj [lemma='plcgamma'] Gene_or_gene_productt+interceding-token ngrams: was not decreasedt`e2: trigger-arg-path: activate:Positive_activation >dobj [lemma='plcgamma'] Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation >nsubj controller:Gene_or_gene_producttBe2: trigger-arg-path: activate >dobj [lemma='plcgamma'] controlledtae1: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttLe2: trigger-arg-path: activate >dobj [lemma='plcgamma'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: activate SHAREDt,interceding-token ngrams: not decreased upontBe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj controllert4e1: ents2Label-mention-ngram: SHARED phosphorylationtNe2: trigger-arg-path: activate:Positive_activation >nsubj Gene_or_gene_producttDe2: trigger-arg-path: activate >dobj controlled:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='egfr'] controllert0e2: args2Role-mention-ngram: activate CONTROLLEDtVe1: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_productt#interceding-token ngrams: depletiont6e2: args2Role-mention-ngram: still activate CONTROLLEDt!interceding-token ngrams: was nottVe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controllert'e2: ents2Label-mention-ngram: can stillt#e2: all-labels: Positive_activationtke2: trigger-arg-path: activate:Positive_activation >dobj [lemma='plcgamma'] controlled:Gene_or_gene_productt=e1-label: Positive_regulation + e2-label: Positive_activationt?e2: trigger-arg-path: activate >nsubj [lemma='egfr'] controllerthe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='egfr'] controller:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='plcgamma'] controlled:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='plcgamma'] Gene_or_gene_producttXe2: trigger-arg-path: activate:Positive_activation >dobj controlled:Gene_or_gene_producttEe2: trigger-arg-path: Positive_activation >nsubj Gene_or_gene_productt+e2: args2Role-mention-ngram: CONTROLLER cantWe2: trigger-arg-path: activate >dobj [lemma='plcgamma'] controlled:Gene_or_gene_producttMe2: trigger-arg-path: Positive_activation >dobj [lemma='plcgamma'] controlledt_e2: trigger-arg-path: Positive_activation >nsubj [lemma='egfr'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED can stilltne1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controllertie1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by Gene_or_gene_productt9e2: trigger-arg-path: activate >dobj Gene_or_gene_productt!e2: ents2Label-mention-ngram: cantze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='egfr'] controller:Gene_or_gene_producttTe2: trigger-arg-path: activate >nsubj [lemma='egfr'] controller:Gene_or_gene_productt0interceding-token ngrams: depletion , suggestingt0e2: trigger-arg-path: activate >nsubj controllert3e2: ents2Label-mention-ngram: still activate SHAREDt`interceding-tokens-full-span: was not decreased upon cholesterol depletion , suggesting that thetRe1: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by controller:Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=activate >dobj controlledt?shortest-path: xcomp [lemma='suggest'] >ccomp [lemma='activate'] >nsubj [lemma='egfr']tVe2: trigger-arg-path: lemmatizedTrigger=activate >dobj controlled:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='plcgamma'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of Simple_chemicaltBe2: trigger-arg-path: Positive_regulation >nn Gene_or_gene_producttwe1: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllertZe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of controller:Simple_chemicaltte1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert]e1: trigger-arg-path: enhanced:Positive_regulation >nsubj >prep_of controller:Simple_chemicalt6e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL enhancedt?e2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn [lemma='egf'] controller:Gene_or_gene_productt|e1: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicalt:e1: ents2Label-mention-ngram: mediated autophosphorylationt8e2: trigger-arg-path: autophosphorylation >nn controllert1e2: ents2Label-mention-ngram: autophosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicalte2: incoming: nn [lemma='egf'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: autophosphorylation of thet9e1: trigger-arg-path: enhanced >nsubj >prep_of controllert+e2: ents2Label-mention-ngram: of the SHAREDt-e1: ents2Label-mention-ngram: enhanced SHAREDtPe2: trigger-arg-path: Positive_regulation >nn [lemma='egf'] Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER enhancedtitrigger-to-trigger-path: e1:enhanced:Positive_regulation >dobj e2:autophosphorylation:Positive_regulationtAe1: ents2Label-mention-ngram: SHARED mediated autophosphorylationt=e1: ents2Label-mention-ngram: mediated autophosphorylation oftBe2: trigger-arg-path: autophosphorylation >nn Gene_or_gene_producttoe2: trigger-arg-path: autophosphorylation:Positive_regulation >nn [lemma='egf'] controller:Gene_or_gene_productt=e2: ents2Label-mention-ngram: mediated autophosphorylation oftLe2: trigger-arg-path: autophosphorylation:Positive_regulation >nn controllert-e1: ents2Label-mention-ngram: SHARED mediatedt%e1: args2Role-mention-ngram: enhancedt[e2: trigger-arg-path: autophosphorylation >nn [lemma='egf'] controller:Gene_or_gene_producttne1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllertFe2: trigger-arg-path: Positive_regulation >nn [lemma='egf'] controllert$e1: ents2Label-mention-ngram: of thet e2: trigger: autophosphorylationt^e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >prep_of controllert&e1: ents2Label-mention-ngram: enhancedtIe1: trigger-arg-path: Positive_regulation >nsubj >prep_of Simple_chemicalt&e1: ents2Label-mention-ngram: mediatedt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert>e1: trigger-arg-path: enhanced >nsubj >prep_of Simple_chemicaltVe2: trigger-arg-path: autophosphorylation:Positive_regulation >nn Gene_or_gene_productt8e2: trigger-arg-path: Positive_regulation >nn controllert4e2: ents2Label-mention-ngram: autophosphorylation oft;e1: args2Role-mention-ngram: CONTROLLER enhanced CONTROLLEDtle2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn [lemma='egf'] controllertve2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn [lemma='egf'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL enhanced SHAREDt^e2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn controllert+e1: ents2Label-mention-ngram: of the SHAREDt:e2: ents2Label-mention-ngram: mediated autophosphorylationtAe2: ents2Label-mention-ngram: SHARED mediated autophosphorylationt6e1: ents2Label-mention-ngram: enhanced SHARED mediatedtPe2: trigger-arg-path: autophosphorylation >nn [lemma='egf'] Gene_or_gene_productt0e2: args2Role-mention-ngram: mediated CONTROLLEDt?e1: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicalte1: trigger: enhancedtce1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >prep_of Simple_chemicalt0e2: args2Role-mention-ngram: CONTROLLER mediatedt8e1: ents2Label-mention-ngram: autophosphorylation of thethe1: trigger-arg-path: enhanced >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicaltMe2: trigger-arg-path: autophosphorylation >nn controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: of thetMe2: trigger-arg-path: Positive_regulation >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicaltTe1: trigger-arg-path: Positive_regulation >nsubj >prep_of controller:Simple_chemicaltXe2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn [lemma='egf'] controllert;e2: args2Role-mention-ngram: CONTROLLER mediated CONTROLLEDtse1: trigger-arg-path: enhanced >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicaltRe1: trigger-arg-path: enhanced:Positive_regulation >nsubj >prep_of Simple_chemicaltye1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicaltJe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of controllertse1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn Gene_or_gene_producttFe2: trigger-arg-path: autophosphorylation >nn [lemma='egf'] controllert~e1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicaltZe2: trigger-arg-path: autophosphorylation:Positive_regulation >nn [lemma='egf'] controllert[e2: trigger-arg-path: Positive_regulation >nn [lemma='egf'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicalt(shortest-path: dobj >nnt0e1: args2Role-mention-ngram: enhanced CONTROLLEDtbe2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn [lemma='egf'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn [lemma='egf'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: autophosphorylationtne1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >prep_of controller:Simple_chemicaltae2: trigger-arg-path: autophosphorylation:Positive_regulation >nn controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn controllertMe1: trigger-arg-path: enhanced:Positive_regulation >nsubj >prep_of controllert?trigger-to-trigger-path: e1:enhanced:Positive_regulation >dobj [lemma='autophosphorylation'] e2:autophosphorylation:Positive_regulationtzshortest-path: dobj [lemma='autophosphorylation'] >nn [lemma='egf']tce1: trigger-arg-path: enhanced >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert4e1: ents2Label-mention-ngram: autophosphorylation ofthe2: trigger-arg-path: lemmatizedTrigger=autophosphorylation:Positive_regulation >nn Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED mediatedt_e2: trigger-arg-path: lemmatizedTrigger=autophosphorylation >nn controller:Gene_or_gene_producttIe1: trigger-arg-path: enhanced >nsubj >prep_of controller:Simple_chemicalt;e1: args2Role-mention-ngram: depletion prevented CONTROLLEDtIe1: trigger-arg-path: prevented:Negative_regulation >nsubj >nn controllertlshortest-path: ccomp [lemma='induce'] >nsubj [lemma='egf']tUe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] controllert7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL depletiont8e1: ents2Label-mention-ngram: induced phosphorylation oftfe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt'shortest-path: ccomp >nsubjtNe1: trigger-arg-path: prevented:Negative_regulation >nsubj >nn Simple_chemicalt9e2: trigger-arg-path: induced >nsubj Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >nn Simple_chemicaltse1: trigger-arg-path: prevented:Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controllerte1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controller:Simple_chemicaltnsubj >nn controllert8e1: ents2Label-mention-ngram: depletion prevented SHAREDtYe1: trigger-arg-path: prevented:Negative_regulation >nsubj >nn controller:Simple_chemicalt5e1: ents2Label-mention-ngram: induced phosphorylationt[e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt:e1: trigger-arg-path: prevented >nsubj >nn Simple_chemicalt=e2: trigger-arg-path: induced >nsubj [lemma='egf'] controllertxe1: trigger-arg-path: prevented:Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] Simple_chemicalt_trigger-to-trigger-path: e1:prevented:Negative_regulation >ccomp e2:induced:Positive_regulationtTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controllertne1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] Simple_chemicaltie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] Simple_chemicaltGe2: trigger-arg-path: induced >nsubj [lemma='egf'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >nn controller:Simple_chemicaltJe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controllert^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Gene_or_gene_productt8e2: ents2Label-mention-ngram: induced phosphorylation oft6e1: ents2Label-mention-ngram: prevented SHARED inducedt5e2: ents2Label-mention-ngram: induced phosphorylationtOe1: trigger-arg-path: Negative_regulation >nsubj >nn controller:Simple_chemicaltEe1: trigger-arg-path: prevented >nsubj >nn controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] Simple_chemicalt_e1: trigger-arg-path: prevented >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controllert1e1: ents2Label-mention-ngram: depletion preventedtMe2: trigger-arg-path: induced:Positive_regulation >nsubj Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >nn Simple_chemicaltnsubj [lemma='depletion'] >nn [lemma='cholesterol'] controller:Simple_chemicalt&e1: args2Role-mention-ngram: depletiont;e1: args2Role-mention-ngram: CONTROLLER depletion preventedtAe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL depletion preventedtXe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] Gene_or_gene_producttptrigger-to-trigger-path: e1:prevented:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationtNe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] controllertRe2: trigger-arg-path: induced >nsubj [lemma='egf'] controller:Gene_or_gene_producttye1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controller:Simple_chemicaltde1: trigger-arg-path: prevented >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] Simple_chemicaltie1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controllertYe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >nn controllertQe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] controllertDe2: trigger-arg-path: induced >nsubj controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] controller:Gene_or_gene_productt5e1: trigger-arg-path: prevented >nsubj >nn controllert/e2: trigger-arg-path: induced >nsubj controllertCe2: trigger-arg-path: induced:Positive_regulation >nsubj controllertoe1: trigger-arg-path: prevented >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controller:Simple_chemicaltEe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >nn controllert.e1: ents2Label-mention-ngram: prevented SHAREDt1e1: args2Role-mention-ngram: CONTROLLER depletiontle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controllert,e1: ents2Label-mention-ngram: SHARED inducedt0e1: args2Role-mention-ngram: depletion preventedt1e1: args2Role-mention-ngram: prevented CONTROLLEDtwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: depletiontDe1: trigger-arg-path: Negative_regulation >nsubj >nn Simple_chemicalt@e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj controllert,e2: ents2Label-mention-ngram: SHARED inducedtXe2: trigger-arg-path: induced:Positive_regulation >nsubj controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >nn controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='depletion'] >nn [lemma='cholesterol'] controller:Simple_chemicalt%interceding-token ngrams: an in vitrot#interceding-token ngrams: p75 NTR ,tce1: trigger-arg-path: interacted:Binding >prep_with [lemma='caveolin-1'] theme:Gene_or_gene_productt1e1-label: Binding + e2-label: Negative_regulationt4e1: ents2Label-mention-ngram: SHARED interacted witht0interceding-token ngrams: kinase assay indicatedtdtrigger-to-trigger-path: e1:interacted:Binding >advcl >ccomp >ccomp e2:inhibited:Negative_regulationtKe2: trigger-arg-path: inhibited >ccomp [lemma='induce'] Positive_regulationt[e2: trigger-arg-path: inhibited >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_producttinterceding-token ngrams: NTR ,tinterceding-token ngrams: an intPe2: trigger-arg-path: Negative_regulation >nsubj controller:Gene_or_gene_productt2e1: args2Role-mention-ngram: interacted with THEMEtPe2: trigger-arg-path: inhibited >nsubj [lemma='caveolin-1'] Gene_or_gene_producttZe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] controllertDe2: trigger-arg-path: Negative_regulation >ccomp Positive_regulationtinterceding-token ngrams: vitrotAe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controllert interceding-token ngrams: and ant-e1: ents2Label-mention-ngram: interacted withtXe1: trigger-arg-path: Binding >prep_with [lemma='caveolin-1'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp Positive_regulationt;e2: trigger-arg-path: Negative_regulation >ccomp controlledt1e2: trigger-arg-path: inhibited >nsubj controllertFe2: trigger-arg-path: inhibited >nsubj [lemma='caveolin-1'] controllertDe1: trigger-arg-path: interacted:Binding >nsubj Gene_or_gene_productt[e1: trigger-arg-path: interacted >prep_with [lemma='caveolin-1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: inhibited >ccomp controlled:Positive_regulationtVe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='caveolin-1'] themetinterceding-token ngrams: , andtKe1: trigger-arg-path: interacted >nsubj [lemma='trka'] Gene_or_gene_productt,interceding-token ngrams: vitro kinase assayt@e1: trigger-arg-path: interacted >prep_with Gene_or_gene_productt;e2: trigger-arg-path: inhibited >nsubj Gene_or_gene_producttSe1: trigger-arg-path: interacted:Binding >nsubj [lemma='trka'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp controlled:Positive_regulationtCe1: trigger-arg-path: Binding >prep_with [lemma='caveolin-1'] themet[e2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] Positive_regulationtde2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER inhibitedtfe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] controlled:Positive_regulationtUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp controlledt)interceding-token ngrams: assay indicatedtNe1: trigger-arg-path: Binding >nsubj [lemma='trka'] theme:Gene_or_gene_producttDe1: trigger-arg-path: interacted:Binding >nsubj [lemma='trka'] themetJe1: trigger-arg-path: interacted:Binding >nsubj theme:Gene_or_gene_productt interceding-token ngrams: as didtee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='caveolin-1'] Gene_or_gene_productt#interceding-token ngrams: and an intnsubj [lemma='trka'] theme:Gene_or_gene_producttUe1: trigger-arg-path: interacted >prep_with [lemma='caveolin-1'] Gene_or_gene_producttEe2: trigger-arg-path: inhibited:Negative_regulation >ccomp controlledtNe1: trigger-arg-path: interacted:Binding >prep_with theme:Gene_or_gene_productte1: trigger: interactedtae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='trka'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controller:Gene_or_gene_productt-e1: trigger-arg-path: interacted >nsubj themet#interceding-token ngrams: indicatedt2e1: args2Role-mention-ngram: THEME interacted witht4e1: ents2Label-mention-ngram: interacted with SHAREDtCe2: ents2Label-mention-ngram: SHARED inhibited GENE_OR_GENE_PRODUCTtNe1: trigger-arg-path: interacted:Binding >prep_with [lemma='caveolin-1'] themetse1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='caveolin-1'] theme:Gene_or_gene_productt:e2: trigger-arg-path: inhibited >ccomp Positive_regulationt.e2: ents2Label-mention-ngram: SHARED inhibitedtBe1: trigger-arg-path: interacted >nsubj theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED interactedtOe2: trigger-arg-path: Negative_regulation >ccomp controlled:Positive_regulationt%interceding-token ngrams: did p75 NTRtze2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtVe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] controllertinterceding-token ngrams: didt;e2: trigger-arg-path: Negative_regulation >nsubj controllertLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='trka'] themetVe2: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] controlledt\interceding-tokens-full-span: , as did p75 NTR , and an in vitro kinase assay indicated thattnsubj [lemma='trka'] Gene_or_gene_producttoe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productt1shortest-path: advcl >ccomp >ccomp >nsubjtinterceding-token ngrams: p75tFe2: trigger-arg-path: inhibited >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: in vitrot.interceding-token ngrams: assay indicated thattFe1: trigger-arg-path: interacted >prep_with theme:Gene_or_gene_productt1e2: trigger-arg-path: inhibited >ccomp controlledt&e2: args2Role-mention-ngram: inhibitedtDe2: ents2Label-mention-ngram: inhibited GENE_OR_GENE_PRODUCT inducedtZe2: trigger-arg-path: inhibited:Negative_regulation >nsubj controller:Gene_or_gene_producttBe2: trigger-arg-path: inhibited >ccomp [lemma='induce'] controlledt'e2: ents2Label-mention-ngram: inhibitedt&interceding-token ngrams: vitro kinasete2: trigger: inhibitedt9e1: trigger-arg-path: Binding >nsubj [lemma='trka'] themetFe1: trigger-arg-path: interacted >prep_with [lemma='caveolin-1'] themet$interceding-token ngrams: as did p75t1e1: trigger-arg-path: interacted >prep_with themetRe1: trigger-arg-path: Binding >prep_with [lemma='caveolin-1'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controllertinterceding-token ngrams: ant^e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='caveolin-1'] themetinterceding-token ngrams: NTRtRe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] controlledtVe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:Gene_or_gene_producttEe2: trigger-arg-path: inhibited:Negative_regulation >nsubj controllert?trigger-to-trigger-path: e1:interacted:Binding >advcl [lemma='do'] >ccomp [lemma='indicate'] >ccomp [lemma='inhibit'] e2:inhibited:Negative_regulationtte2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_producttEe2: trigger-arg-path: Negative_regulation >nsubj Gene_or_gene_producttinterceding-token ngrams: assaytinterceding-token ngrams: int#interceding-token ngrams: NTR , andtee2: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productt"interceding-token ngrams: , and antNe2: trigger-arg-path: inhibited:Negative_regulation >ccomp Positive_regulationt)interceding-token ngrams: in vitro kinaset!interceding-token ngrams: did p75tinterceding-token ngrams: , astnsubj Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp controlledtfe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] controlledte2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productt`e2: trigger-arg-path: Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtZe2: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_productt'e1: args2Role-mention-ngram: interactedt(interceding-token ngrams: indicated thattie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp controlled:Positive_regulationt,e1: args2Role-mention-ngram: interacted withtTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='trka'] themetPe2: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] controllert-e1: args2Role-mention-ngram: THEME interactedtje2: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtYe1: trigger-arg-path: interacted:Binding >nsubj [lemma='trka'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: interactedt9e1: trigger-arg-path: interacted:Binding >prep_with themetYe2: trigger-arg-path: inhibited:Negative_regulation >ccomp controlled:Positive_regulationtHe1: trigger-arg-path: Binding >nsubj [lemma='trka'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='caveolin-1'] Gene_or_gene_productt?shortest-path: advcl [lemma='do'] >ccomp [lemma='indicate'] >ccomp [lemma='inhibit'] >nsubj [lemma='caveolin-1']t!interceding-token ngrams: p75 NTRt@e2: ents2Label-mention-ngram: induced SHARED autophosphorylationtoe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtLe2: trigger-arg-path: Negative_regulation >ccomp [lemma='induce'] controlledt interceding-token ngrams: kinasetVe2: trigger-arg-path: inhibited >ccomp [lemma='induce'] controlled:Positive_regulationt"interceding-token ngrams: , as didtnsubj [lemma='trka'] themet8e2: ents2Label-mention-ngram: SHARED autophosphorylationt1e2: args2Role-mention-ngram: inhibited CONTROLLEDtinterceding-token ngrams: ast_e2: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtje2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] controllertOe2: trigger-arg-path: inhibited:Negative_regulation >nsubj Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] Gene_or_gene_producttQe1: trigger-arg-path: interacted >nsubj [lemma='trka'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='trka'] Gene_or_gene_producttUe2: trigger-arg-path: Negative_regulation >ccomp [lemma='induce'] Positive_regulationt&interceding-token ngrams: kinase assayt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='caveolin-1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp Positive_regulationt5e1: trigger-arg-path: interacted:Binding >nsubj themet]e1: trigger-arg-path: interacted:Binding >prep_with [lemma='caveolin-1'] Gene_or_gene_producttHe1: trigger-arg-path: interacted:Binding >prep_with Gene_or_gene_producttBe2: trigger-arg-path: induced:Positive_regulation >dobj controlledtje1: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtFe1: trigger-arg-path: inhibited >nsubj controller:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] controlledt]e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='autophosphorylation'] controlledt_trigger-to-trigger-path: e1:inhibited:Negative_regulation >ccomp e2:induced:Positive_regulationt^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp Positive_regulationtUe1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp controlled:Positive_regulationtQe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ngf'] controllerthe2: trigger-arg-path: Positive_regulation >dobj [lemma='autophosphorylation'] controlled:PhosphorylationtPe1: trigger-arg-path: Negative_regulation >nsubj controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED induced SHAREDtke1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_producttZe1: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_producttEe1: trigger-arg-path: inhibited:Negative_regulation >nsubj controllertPe1: trigger-arg-path: inhibited >nsubj [lemma='caveolin-1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp controlledt[e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ngf'] Gene_or_gene_producttee1: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_producttEe1: trigger-arg-path: Negative_regulation >nsubj Gene_or_gene_productt@e1: ents2Label-mention-ngram: induced SHARED autophosphorylationtTshortest-path: ccomp [lemma='induce'] >nsubj [lemma='ngf']t:e2: trigger-arg-path: Positive_regulation >dobj controlledtje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] controllertCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibited SHAREDtfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] controlledtce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ngf'] controller:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj PhosphorylationtGe2: trigger-arg-path: induced:Positive_regulation >dobj PhosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ngf'] Gene_or_gene_productt1e1: trigger-arg-path: inhibited >ccomp controlledtGe2: trigger-arg-path: induced >nsubj [lemma='ngf'] Gene_or_gene_producttRe2: trigger-arg-path: induced >nsubj [lemma='ngf'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED induced SHAREDt[e1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] Positive_regulationtJe2: trigger-arg-path: Positive_regulation >dobj controlled:Phosphorylationtccomp [lemma='induce'] controlled:Positive_regulationt_e1: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] Positive_regulationt`e2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='autophosphorylation'] controlledt;e1: trigger-arg-path: Negative_regulation >ccomp controlledtOe1: trigger-arg-path: Negative_regulation >ccomp controlled:Positive_regulationtVe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] controllerte1: trigger: inhibitedtAe1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp controlledtJe1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp Positive_regulationt8e1: ents2Label-mention-ngram: SHARED autophosphorylationtbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ngf'] controllertXe2: trigger-arg-path: Positive_regulation >dobj [lemma='autophosphorylation'] controlledtde1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='caveolin-1'] Gene_or_gene_producttpe2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='autophosphorylation'] controlled:PhosphorylationtVe1: trigger-arg-path: inhibited:Negative_regulation >ccomp [lemma='induce'] controlledtoe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_producttZe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='caveolin-1'] controllertve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='autophosphorylation'] Phosphorylationt;e1: trigger-arg-path: inhibited >nsubj Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >dobj PhosphorylationtQe2: trigger-arg-path: induced >dobj [lemma='autophosphorylation'] Phosphorylationt.e1: ents2Label-mention-ngram: inhibited SHAREDtee2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='autophosphorylation'] Phosphorylationtqe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='autophosphorylation'] controlledtLe2: trigger-arg-path: induced >dobj [lemma='autophosphorylation'] controlledtUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controllertie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp controlled:Positive_regulationtNe1: trigger-arg-path: inhibited:Negative_regulation >ccomp Positive_regulationtEe1: trigger-arg-path: inhibited >ccomp controlled:Positive_regulationtwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ngf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='autophosphorylation'] controlled:PhosphorylationtSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ngf'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ngf'] Gene_or_gene_productt&e1: args2Role-mention-ngram: inhibitedtRe2: trigger-arg-path: induced:Positive_regulation >dobj controlled:Phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='autophosphorylation'] controlled:Phosphorylationt_e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] controlled:Positive_regulationtje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controller:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controlled:PhosphorylationtOe1: trigger-arg-path: inhibited:Negative_regulation >nsubj Gene_or_gene_producttptrigger-to-trigger-path: e1:inhibited:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationt1e1: trigger-arg-path: inhibited >nsubj controllertBe1: trigger-arg-path: inhibited >ccomp [lemma='induce'] controlledt1e1: args2Role-mention-ngram: inhibited CONTROLLEDt=e2: trigger-arg-path: induced >nsubj [lemma='ngf'] controllertSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controlledtfe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ngf'] controller:Gene_or_gene_producttEe1: trigger-arg-path: inhibited:Negative_regulation >ccomp controlledtnsubj [lemma='caveolin-1'] controllertbe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='autophosphorylation'] PhosphorylationtKe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Gene_or_gene_producttDe1: trigger-arg-path: Negative_regulation >ccomp Positive_regulationtUe1: trigger-arg-path: Negative_regulation >ccomp [lemma='induce'] Positive_regulationt'e1: ents2Label-mention-ngram: inhibitedt\e2: trigger-arg-path: induced >dobj [lemma='autophosphorylation'] controlled:PhosphorylationtIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ngf'] controllertYe1: trigger-arg-path: inhibited:Negative_regulation >ccomp controlled:Positive_regulationtPe1: trigger-arg-path: Negative_regulation >nsubj [lemma='caveolin-1'] controllertVe1: trigger-arg-path: inhibited >ccomp [lemma='induce'] controlled:Positive_regulationtZe1: trigger-arg-path: inhibited:Negative_regulation >nsubj controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] Gene_or_gene_producttKe1: trigger-arg-path: inhibited >ccomp [lemma='induce'] Positive_regulationtAe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controllert[e1: trigger-arg-path: inhibited >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='caveolin-1'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: inhibited SHARED inducedt]e2: trigger-arg-path: Positive_regulation >dobj [lemma='autophosphorylation'] Phosphorylationt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ngf'] controller:Gene_or_gene_productt:e1: trigger-arg-path: inhibited >ccomp Positive_regulationtoe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtNe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ngf'] controllertLe1: trigger-arg-path: Negative_regulation >ccomp [lemma='induce'] controlledtze1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt1e1: args2Role-mention-ngram: CONTROLLER inhibitedt?shortest-path: advcl [lemma='do'] >ccomp [lemma='indicate'] >ccomp [lemma='inhibit'] >ccomp [lemma='induce'] >nsubj [lemma='ngf']tqinterceding-tokens-full-span: , as did p75 NTR , and an in vitro kinase assay indicated that caveolin-1 inhibitedt3interceding-token ngrams: that caveolin-1 inhibitedt)interceding-token ngrams: that caveolin-1t?trigger-to-trigger-path: e1:interacted:Binding >advcl [lemma='do'] >ccomp [lemma='indicate'] >ccomp [lemma='inhibit'] >ccomp [lemma='induce'] e2:induced:Positive_regulationt1e1-label: Binding + e2-label: Positive_regulationt8shortest-path: advcl >ccomp >ccomp >ccomp >nsubjtsortest-path-dist: 6t.interceding-token ngrams: caveolin-1 inhibitedtitrigger-to-trigger-path: e1:interacted:Binding >advcl >ccomp >ccomp >ccomp e2:induced:Positive_regulationtBe1: ents2Label-mention-ngram: interacted with GENE_OR_GENE_PRODUCTt3interceding-token ngrams: indicated that caveolin-1t$interceding-token ngrams: caveolin-1ttrigger-dist: 4t#interceding-token ngrams: inhibitedt'e2: ents2Label-mention-ngram: RA domaint9e1: trigger-arg-path: binds:Binding >nsubj >prep_of themetEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj site:Sitet+e1: args2Role-mention-ngram: of THEME bindst*e2: trigger-arg-path: binds >prep_to themetce2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themete2: SITE: 1t1e2: trigger-arg-path: binds >nsubj >prep_of themetae2: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: RA domain oft8e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj sitet,e1: trigger-arg-path: binds >nsubj site:Sitetshortest-path: nsubj [lemma='domain'] sitet@e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj sitet:e1: trigger-arg-path: Binding >nsubj [lemma='domain'] Sitetie1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: binds tote2: args2Role-mention-ngram: totDe1: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] themet-e2: ents2Label-mention-ngram: SHARED binds tot8e2: trigger-arg-path: binds >nsubj [lemma='domain'] Sitet;e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to themet'e2: trigger-arg-path: binds >nsubj sitet"e2: args2Role-mention-ngram: bindstUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] themet-e2: ents2Label-mention-ngram: binds to SHAREDtAe2: trigger-arg-path: Binding >prep_to theme:Gene_or_gene_productt)e1: trigger-arg-path: Binding >nsubj Sitetce1: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: to SHAREDt.e1: trigger-arg-path: Binding >nsubj site:Sitet,e2: trigger-arg-path: Binding >prep_to themetprep_to [lemma='ras-gtp'] themetce2: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: bindst@e1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] sitetQe1: trigger-arg-path: binds >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_productt,e2: trigger-arg-path: binds >nsubj site:SitetSe1: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_productt@e1: trigger-arg-path: binds >nsubj >prep_of Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of Gene_or_gene_productt3e1: trigger-arg-path: Binding >nsubj >prep_of themetZe2: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of themetBe1: trigger-arg-path: Binding >nsubj >prep_of Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] site:Sitetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_productte1: THEME: 2t%e2: args2Role-mention-ngram: to THEMEt@e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Sitet@e2: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] SitetUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] themetRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to Gene_or_gene_productt/e1: trigger-arg-path: binds:Binding >nsubj Sitet8e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj SitetSe2: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] Sitete1: SITE: 1t=e1: trigger-arg-path: binds >nsubj [lemma='domain'] site:Sitet9e2: trigger-arg-path: binds:Binding >nsubj >prep_of themet&e2: ents2Label-mention-ngram: binds tot4e1: trigger-arg-path: binds:Binding >nsubj site:SitetAe2: trigger-arg-path: binds:Binding >prep_to Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] site:Sitet:e2: trigger-arg-path: Binding >nsubj [lemma='domain'] sitet\e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: of SHARED bindst'e2: trigger-arg-path: binds >nsubj SitetFe2: trigger-arg-path: binds >nsubj >prep_of theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: THEME binds tot\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt8e1: trigger-arg-path: binds >nsubj [lemma='domain'] sitetbe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_productt/e2: trigger-arg-path: binds:Binding >nsubj sitetDe2: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] SitetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] sitetGe2: trigger-arg-path: binds:Binding >prep_to theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_producttie2: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: RA domaintRe1: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] sitetVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] site:Sitetje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] site:Sitetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: binds to SHAREDt*e2: ents2Label-mention-ngram: SHARED bindstJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to Gene_or_gene_productt'e1: trigger-arg-path: binds >nsubj sitetMe1: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_producttprep_to [lemma='ras-gtp'] themetbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_producttHe2: trigger-arg-path: binds:Binding >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: binds >prep_to theme:Gene_or_gene_productt8e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj sitet:e2: trigger-arg-path: Binding >nsubj [lemma='domain'] Sitet?e1: trigger-arg-path: Binding >nsubj [lemma='domain'] site:Sitet=e2: trigger-arg-path: binds >nsubj [lemma='domain'] site:SitetEe1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] site:Sitetie1: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj site:Sitet'e1: ents2Label-mention-ngram: to SHAREDtPe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to theme:Gene_or_gene_productt/e2: trigger-arg-path: binds:Binding >nsubj SitetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] SitetTe2: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themet.e2: ents2Label-mention-ngram: domain of SHAREDtZe1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themet@e1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] SitetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] Sitet>e1: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] themete2: trigger: bindst=e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj site:SitetKe1: trigger-arg-path: binds >prep_to [lemma='ras-gtp'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themetoe1: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: SITEtHe1: trigger-arg-path: Binding >nsubj >prep_of theme:Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to themet$e1: args2Role-mention-ngram: SITE oftoe2: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] Gene_or_gene_productt8e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj Sitet'e2: ents2Label-mention-ngram: domain oft)e2: trigger-arg-path: Binding >nsubj sitetre2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_producttKe2: trigger-arg-path: binds >prep_to [lemma='ras-gtp'] Gene_or_gene_producttHe1: trigger-arg-path: binds:Binding >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: Binding >nsubj [lemma='domain'] site:Sitetie2: trigger-arg-path: Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: binds >prep_to Gene_or_gene_productt#shortest-path: nsubj >prep_of themet+e2: args2Role-mention-ngram: of THEME bindst@e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj sitet$e1: ents2Label-mention-ngram: domaintze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt8e1: trigger-arg-path: binds >nsubj [lemma='domain'] SitetSe1: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_productt e1: ents2Label-mention-ngram: RAt=e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj site:Sitet*e1: args2Role-mention-ngram: SITE of THEMEt2e2: trigger-arg-path: binds:Binding >prep_to themet;e2: trigger-arg-path: Binding >prep_to Gene_or_gene_productt'e1: trigger-arg-path: binds >nsubj SitetQe2: trigger-arg-path: binds >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds:Binding >nsubj >prep_of theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themet>e2: trigger-arg-path: Binding >prep_to [lemma='ras-gtp'] themetge1: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: domaintYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of Gene_or_gene_productt1e1: trigger-arg-path: binds >nsubj >prep_of themetke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themetIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] sitet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:Gene_or_gene_productt/e1: trigger-arg-path: binds:Binding >nsubj sitetYe2: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='domain'] sitet e2: ents2Label-mention-ngram: RAtEe2: trigger-arg-path: binds:Binding >nsubj [lemma='domain'] site:SitetYe1: trigger-arg-path: binds:Binding >prep_to [lemma='ras-gtp'] theme:Gene_or_gene_productt)e2: trigger-arg-path: Binding >nsubj Sitetxe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_producttge2: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt@e2: trigger-arg-path: binds >nsubj >prep_of Gene_or_gene_productt+e2: args2Role-mention-ngram: binds to THEMEt)e1: trigger-arg-path: Binding >nsubj sitet$e2: args2Role-mention-ngram: SITE oftke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themet4e2: trigger-arg-path: binds:Binding >nsubj site:SitetMe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] themet@e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Sitet?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] >prep_of [lemma='nore1'] theme:Gene_or_gene_productt!e2: args2Role-mention-ngram: SITEt8e2: trigger-arg-path: binds >nsubj [lemma='domain'] sitet.e2: trigger-arg-path: Binding >nsubj site:Sitet(e2: args2Role-mention-ngram: THEME bindst*e1: ents2Label-mention-ngram: RA domain oftae1: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: of SHARED bindstRe2: trigger-arg-path: binds >nsubj [lemma='domain'] >prep_of [lemma='nore1'] themet%e2: args2Role-mention-ngram: of THEMEtFe1: trigger-arg-path: binds >nsubj >prep_of theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: domain oft*e2: args2Role-mention-ngram: SITE of THEMEtNe2: trigger-arg-path: binds:Binding >nsubj >prep_of theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ras-gtp'] themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='domain'] sitet.e1: ents2Label-mention-ngram: domain of SHAREDt e2: ents2Label-mention-ngram: totinterceding-token ngrams: studyt5e2: trigger-arg-path: bind >dobj [lemma='k-ra'] themet/interceding-token ngrams: dependent manner witht*e1: args2Role-mention-ngram: directly witht0interceding-token ngrams: another study reportedtke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] themetJe2: trigger-arg-path: bind >dobj [lemma='k-ra'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: not bind SHAREDt*e2: args2Role-mention-ngram: does not bindt$interceding-token ngrams: to that oft%interceding-token ngrams: an affinityt+interceding-token ngrams: yet another studyt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: doestTe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] Gene_or_gene_productt/interceding-token ngrams: effectors yet anothertVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] themet4e1: args2Role-mention-ngram: interacts directly withtee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] Gene_or_gene_producttinterceding-token ngrams: a GTPtsortest-path-dist: 10tinterceding-token ngrams: in at&e2: ents2Label-mention-ngram: does nott.interceding-token ngrams: GTP dependent mannert-interceding-token ngrams: known Ras effectorst+e2: args2Role-mention-ngram: THEME does notttrigger-to-trigger-path: e1:interacts:Binding ccomp [lemma='bind'] e2:bind:BindingtVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] Gene_or_gene_producttRe2: trigger-arg-path: bind:Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] themetZe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt'interceding-token ngrams: another studyt+e2: ents2Label-mention-ngram: does not bindt*interceding-token ngrams: with an affinityt\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_productt%interceding-token ngrams: other knownt'e2: args2Role-mention-ngram: bind THEMEt)interceding-token ngrams: a GTP dependentt0interceding-token ngrams: affinity comparable tot*interceding-token ngrams: dependent mannertVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='k-ra'] Gene_or_gene_productt)interceding-token ngrams: other known Rast0interceding-token ngrams: an affinity comparabletJe1: trigger-arg-path: Binding >nsubj [lemma='rassf6'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: bind SHAREDt%interceding-token ngrams: manner witht'interceding-token ngrams: GTP dependenttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] theme:Gene_or_gene_productt?interceding-tokens-full-span: in a GTP dependent manner with an affinity comparable to that of other known Ras effectors yet another study reportedt;e1: trigger-arg-path: Binding >nsubj [lemma='rassf6'] themet=e1: trigger-arg-path: interacts >nsubj [lemma='rassf6'] themete1: outgoing: >advmodtinterceding-token ngrams: othert5e1: args2Role-mention-ngram: THEME interacts directlyt'interceding-token ngrams: effectors yettEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interacts directlyt!interceding-token ngrams: with ant,e2: ents2Label-mention-ngram: GENERIC_ENTITYt+interceding-token ngrams: Ras effectors yettNe1: trigger-arg-path: interacts >prep_with [lemma='k-ra'] Gene_or_gene_productt interceding-token ngrams: mannert(interceding-token ngrams: manner with ant'e2: args2Role-mention-ngram: THEME doest,interceding-token ngrams: comparable to thattinterceding-token ngrams: yett5e2: ents2Label-mention-ngram: GENERIC_ENTITY does nottshortest-path: ccomp [lemma='bind'] >nsubj [lemma='it']t/e1: args2Role-mention-ngram: interacts directlyt_shortest-path: ccomp >nsubjt$interceding-token ngrams: comparabletge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] Gene_or_gene_producttprep_with [lemma='k-ra'] themetTe1: trigger-arg-path: interacts >prep_with [lemma='k-ra'] theme:Gene_or_gene_productt%interceding-token ngrams: yet anothert'interceding-token ngrams: comparable tot+e1: ents2Label-mention-ngram: directly witht2e1: ents2Label-mention-ngram: directly with SHAREDt(interceding-token ngrams: study reportedt#interceding-token ngrams: effectorst!e2: args2Role-mention-ngram: doestinterceding-token ngrams: Rast!interceding-token ngrams: that oftRe1: trigger-arg-path: Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: interacts directlyt#interceding-token ngrams: known Rast"interceding-token ngrams: in a GTPt0e1: args2Role-mention-ngram: directly with THEMEt(interceding-token ngrams: of other knownt!interceding-token ngrams: to thattinterceding-token ngrams: at?trigger-to-trigger-path: e1:interacts:Binding ccomp e2:bind:Bindingt1e2: ents2Label-mention-ngram: GENERIC_ENTITY doest5e1: ents2Label-mention-ngram: interacts directly witht#interceding-token ngrams: dependentt'interceding-token ngrams: that of othertce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttinterceding-token ngrams: knowntRe1: trigger-arg-path: interacts >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='k-ra'] themet'interceding-token ngrams: Ras effectorstNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] themetDe2: trigger-arg-path: bind >dobj [lemma='k-ra'] Gene_or_gene_producttEe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] themetPe1: trigger-arg-path: Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >dobj [lemma='k-ra'] themetGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] themet%e2: args2Role-mention-ngram: does nott\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: not bind THEMEtLe2: trigger-arg-path: bind:Binding >dobj [lemma='k-ra'] Gene_or_gene_productt"interceding-token ngrams: reportedt]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] Gene_or_gene_productt"interceding-token ngrams: of othert=e2: trigger-arg-path: bind:Binding >dobj [lemma='k-ra'] themetGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] themetLe1: trigger-arg-path: interacts >nsubj [lemma='rassf6'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] themetme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >dobj [lemma='k-ra'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: binds thesetOe2: trigger-arg-path: Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: binds:Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt3e1: trigger-arg-path: binds:Binding >dobj >nn themetYe1: trigger-arg-path: binds:Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt(e2: args2Role-mention-ngram: binds thesetce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] themetEe2: trigger-arg-path: binds:Binding >nsubj theme:Gene_or_gene_productt-e1: trigger-arg-path: Binding >dobj >nn themet7e1: trigger-arg-path: binds >nsubj Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_producttKe1: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] Familyt4e1: trigger-arg-path: binds:Binding >dobj >nn Familyt8e2: trigger-arg-path: binds >nsubj [lemma='nore1'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:FamilytOe2: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: binds these SHAREDt0e2: ents2Label-mention-ngram: SHARED binds thesetSe2: trigger-arg-path: binds:Binding >dobj [lemma='protein'] >nn [lemma='ra'] Familyt3e2: trigger-arg-path: binds:Binding >dobj >nn themet:e1: trigger-arg-path: Binding >nsubj [lemma='nore1'] themetKe2: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] Familyt2e1: trigger-arg-path: binds >dobj >nn theme:Familyt4e2: trigger-arg-path: Binding >dobj >nn theme:FamilytGe1: trigger-arg-path: binds >nsubj [lemma='nore1'] Gene_or_gene_productt?e1: trigger-arg-path: binds:Binding >nsubj Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Familyt@e2: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] themetIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Gene_or_gene_productt:e2: trigger-arg-path: binds:Binding >dobj >nn theme:FamilytIe1: trigger-arg-path: Binding >nsubj [lemma='nore1'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:Familyt(e1: args2Role-mention-ngram: binds theset*e1: ents2Label-mention-ngram: these SHAREDtEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Familyt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] Gene_or_gene_productt=e1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn FamilytQe1: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt*e2: ents2Label-mention-ngram: these SHAREDt=e2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn FamilytQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME binds thesetLe2: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] themet.e2: args2Role-mention-ngram: binds these THEMEtSe2: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt9e2: trigger-arg-path: Binding >nsubj Gene_or_gene_productt=e1: trigger-arg-path: binds >nsubj theme:Gene_or_gene_productt+e2: trigger-arg-path: binds >dobj >nn themet:e2: trigger-arg-path: Binding >nsubj [lemma='nore1'] themetEe1: trigger-arg-path: binds:Binding >nsubj theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] theme:Gene_or_gene_producttGe2: trigger-arg-path: binds >nsubj [lemma='nore1'] Gene_or_gene_producttdobj >nn themet@e1: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] themet$shortest-path: dobj [lemma='protein'] >nn [lemma='ra'] themet"e1: args2Role-mention-ngram: thesetVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: these THEMEt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] themet#e1: ents2Label-mention-ngram: thesetbe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt0e2: ents2Label-mention-ngram: binds these SHAREDtNe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Familytje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:FamilytMe1: trigger-arg-path: binds >nsubj [lemma='nore1'] theme:Gene_or_gene_productt=e2: trigger-arg-path: binds >nsubj theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding >nsubj Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] themetbe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt4e2: trigger-arg-path: binds:Binding >dobj >nn Familyt8e1: trigger-arg-path: binds >nsubj [lemma='nore1'] themetPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Gene_or_gene_producttMe2: trigger-arg-path: binds >nsubj [lemma='nore1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] themet"e2: args2Role-mention-ngram: thesetLe1: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] themetSe1: trigger-arg-path: binds:Binding >dobj [lemma='protein'] >nn [lemma='ra'] Familyt.e2: trigger-arg-path: Binding >dobj >nn FamilytJe2: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] themet)e2: ents2Label-mention-ngram: binds theset#e2: ents2Label-mention-ngram: thesetDe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn themetIe2: trigger-arg-path: Binding >nsubj [lemma='nore1'] Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] themet4e1: trigger-arg-path: Binding >dobj >nn theme:Familyt(e1: args2Role-mention-ngram: these THEMEt+e1: trigger-arg-path: binds >dobj >nn themetOe1: trigger-arg-path: Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] FamilytEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Familyt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] FamilytHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] Gene_or_gene_productt(e2: trigger-arg-path: binds >nsubj themet.e1: args2Role-mention-ngram: binds these THEMEt:e1: trigger-arg-path: binds:Binding >dobj >nn theme:Familyt\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='protein'] >nn [lemma='ra'] Familyt,e1: trigger-arg-path: binds >dobj >nn FamilytOe1: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] Gene_or_gene_productt7e2: trigger-arg-path: binds >nsubj Gene_or_gene_productt0e1: ents2Label-mention-ngram: SHARED binds theset?e2: trigger-arg-path: Binding >nsubj theme:Gene_or_gene_productt2e2: trigger-arg-path: binds >dobj >nn theme:FamilytMe2: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] FamilytSe1: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt0e2: trigger-arg-path: binds:Binding >nsubj themetQe2: trigger-arg-path: binds >dobj [lemma='protein'] >nn [lemma='ra'] theme:Familyt.e1: trigger-arg-path: Binding >dobj >nn Familytce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] themetUe1: trigger-arg-path: binds:Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] Gene_or_gene_productt,e2: trigger-arg-path: binds >dobj >nn Familytfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nore1'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: THEME binds thesetMe1: trigger-arg-path: Binding >dobj [lemma='protein'] >nn [lemma='ra'] Familytde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='protein'] >nn [lemma='ra'] FamilytXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nore1'] Gene_or_gene_producttRe2: trigger-arg-path: binds:Binding >dobj [lemma='protein'] >nn [lemma='ra'] themet.e2: trigger-arg-path: Binding >prep_with themetYe1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] controlled:BioProcesst5e2: ents2Label-mention-ngram: SHARED interaction witht^shortest-path: prep_through [lemma='interaction'] >poss [lemma='its']t/e2: trigger-arg-path: Binding >prep_with FamilytKe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with theme:Familyt.e2: ents2Label-mention-ngram: interaction withtUe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='rassf1a'] controllertBe2: trigger-arg-path: Binding >prep_with [lemma='ra'] theme:Familytprep_with [lemma='ra'] FamilytVe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss theme:Generic_entityt:e1: args2Role-mention-ngram: CONTROLLER induces CONTROLLEDt\e2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] theme:Generic_entitytFe2: trigger-arg-path: interaction >prep_with [lemma='ra'] theme:Familytre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='apoptosis'] controlled:BioProcesst3e2: args2Role-mention-ngram: THEME interaction withtJe2: trigger-arg-path: interaction >poss [lemma='its'] theme:Generic_entitytae1: trigger-arg-path: induces:Positive_activation >dobj [lemma='apoptosis'] controlled:BioProcesst^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] Generic_entitytpe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='rassf1a'] Gene_or_gene_productt;e2: trigger-arg-path: Binding >prep_with [lemma='ra'] themet)e2: ents2Label-mention-ngram: with FAMILYt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ra'] theme:Familyt)e2: trigger-arg-path: Binding >poss themet^e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj controlled:BioProcesstAe1: trigger-arg-path: induces >nsubj [lemma='rassf1a'] controllertSe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj BioProcesst:e2: trigger-arg-path: interaction:Binding >prep_with themet?e2: trigger-arg-path: lemmatizedTrigger=interaction >poss themet5e2: ents2Label-mention-ngram: interaction with FAMILYtGe2: trigger-arg-path: interaction:Binding >prep_with [lemma='ra'] themet!interceding-token ngrams: throughtVe1: trigger-arg-path: induces >nsubj [lemma='rassf1a'] controller:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=interaction >poss Generic_entitytVe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='apoptosis'] controlledtAe2: trigger-arg-path: interaction:Binding >prep_with theme:Familyt-e2: args2Role-mention-ngram: interaction witht5e2: trigger-arg-path: Binding >prep_with theme:FamilytDe2: trigger-arg-path: interaction >poss [lemma='its'] Generic_entitytBe1: trigger-arg-path: induces:Positive_activation >dobj BioProcesstNe2: trigger-arg-path: lemmatizedTrigger=interaction >poss theme:Generic_entitytSe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with theme:Familyt\e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rassf1a'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='apoptosis'] controlled:BioProcesstWe1: trigger-arg-path: Positive_activation >nsubj [lemma='rassf1a'] Gene_or_gene_productt!e2: args2Role-mention-ngram: withtfe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='rassf1a'] controllertRe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rassf1a'] controllert\trigger-to-trigger-path: e1:induces:Positive_activation >prep_through e2:interaction:Bindingt:e1: trigger-arg-path: Positive_activation >dobj controlledtge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='apoptosis'] BioProcesst;e2: trigger-arg-path: interaction >poss [lemma='its'] themet9e2: trigger-arg-path: interaction >prep_with theme:FamilytKe1: trigger-arg-path: induces >nsubj [lemma='rassf1a'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] theme:Generic_entityt'e2: args2Role-mention-ngram: with THEMEtFe2: trigger-arg-path: Binding >poss [lemma='its'] theme:Generic_entitytSe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='apoptosis'] BioProcesst.e1: trigger-arg-path: induces >dobj BioProcesstYe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ra'] themetbe1: trigger-arg-path: Positive_activation >nsubj [lemma='rassf1a'] controller:Gene_or_gene_producttNe1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] BioProcesst/e1: args2Role-mention-ngram: induces CONTROLLEDtMe2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] themet3e2: args2Role-mention-ngram: interaction with THEMEtrtrigger-to-trigger-path: e1:induces:Positive_activation >prep_through [lemma='interaction'] e2:interaction:BindingtBe1: trigger-arg-path: induces >dobj [lemma='apoptosis'] BioProcesstNe2: trigger-arg-path: interaction:Binding >prep_with [lemma='ra'] theme:Familyt>e2: trigger-arg-path: interaction:Binding >poss Generic_entityte2: incoming: prep_with [lemma='ra'] themet;e2: trigger-arg-path: interaction:Binding >prep_with FamilytEe1: trigger-arg-path: Positive_activation >dobj controlled:BioProcesst?e1: trigger-arg-path: lemmatizedTrigger=induce >dobj BioProcesst0e1: ents2Label-mention-ngram: induces BIOPROCESSt)shortest-path: prep_through >posstRe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ra'] FamilytSe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj controlledtDe2: trigger-arg-path: interaction:Binding >poss theme:Generic_entitytje1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='rassf1a'] controller:Gene_or_gene_productt?e2: trigger-arg-path: interaction >prep_with [lemma='ra'] themetRe2: trigger-arg-path: interaction:Binding >poss [lemma='its'] theme:Generic_entitytMe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with FamilytHe2: trigger-arg-path: interaction:Binding >prep_with [lemma='ra'] Familyte2: trigger: interactiontGe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss themetBe1: trigger-arg-path: induces:Positive_activation >dobj controlledtVe2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] Generic_entitytge1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rassf1a'] controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED induces BIOPROCESStJe1: trigger-arg-path: lemmatizedTrigger=induce >dobj controlled:BioProcesstge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='apoptosis'] controlledt.e2: args2Role-mention-ngram: THEME interactiont,e1: ents2Label-mention-ngram: SHARED inducestCe2: trigger-arg-path: interaction:Binding >poss [lemma='its'] themetPe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss Generic_entityt5e2: trigger-arg-path: interaction:Binding >poss themet7e2: trigger-arg-path: Binding >poss [lemma='its'] themet_e1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='rassf1a'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] themet(e2: args2Role-mention-ngram: interactiontMe1: trigger-arg-path: Positive_activation >nsubj [lemma='rassf1a'] controllert@e2: trigger-arg-path: interaction >prep_with [lemma='ra'] Familyt8e2: trigger-arg-path: Binding >poss theme:Generic_entityt6e2: trigger-arg-path: interaction >poss Generic_entityt2e2: trigger-arg-path: interaction >prep_with themet3e2: trigger-arg-path: interaction >prep_with Familyt-e2: trigger-arg-path: interaction >poss themetLe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with themetDe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with themetXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ra'] theme:FamilytMe1: trigger-arg-path: induces:Positive_activation >dobj controlled:BioProcesstVe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='apoptosis'] BioProcesstZe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ra'] Familytposs theme:Generic_entityt{e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='rassf1a'] controller:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with Familyt(e1: ents2Label-mention-ngram: BIOPROCESStMe1: trigger-arg-path: induces >dobj [lemma='apoptosis'] controlled:BioProcesst@e2: trigger-arg-path: Binding >poss [lemma='its'] Generic_entityt:e1: trigger-arg-path: Positive_activation >dobj BioProcesstSe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='apoptosis'] controlledtBe1: trigger-arg-path: induces >dobj [lemma='apoptosis'] controlledtNe1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] controlledt.e1: trigger-arg-path: induces >dobj controlledtLe2: trigger-arg-path: interaction:Binding >poss [lemma='its'] Generic_entityt0e2: ents2Label-mention-ngram: SHARED interactiont2e2: trigger-arg-path: Binding >poss Generic_entityt9e1: trigger-arg-path: induces >dobj controlled:BioProcesst%interceding-tokens-full-span: throught)e2: args2Role-mention-ngram: can interacttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mst1'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mst1'] themetHe1: trigger-arg-path: Binding >nsubj [lemma='cnk1'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCTt!interceding-token ngrams: but nott>e1: trigger-arg-path: bind:Binding >nsubj Gene_or_gene_producttLe2: trigger-arg-path: interact:Binding >prep_with theme:Gene_or_gene_producttLe2: trigger-arg-path: interact >nsubj [lemma='rassf1a'] Gene_or_gene_productt)e1: trigger-arg-path: Binding >dobj themet7e2: trigger-arg-path: interact:Binding >prep_with themet/e2: ents2Label-mention-ngram: can interact withtSe1: trigger-arg-path: bind:Binding >nsubj [lemma='cnk1'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1a'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >dobj [lemma='rassf1a'] themet&e1: trigger-arg-path: bind >dobj themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with theme:Gene_or_gene_producttOe1: trigger-arg-path: bind:Binding >dobj [lemma='rassf1a'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk1'] Gene_or_gene_producttZe2: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt$interceding-token ngrams: or RASSF1CtRe2: trigger-arg-path: interact >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttEe2: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] themetIe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with themetinterceding-token ngrams: ort/e2: trigger-arg-path: interact >prep_with themetWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] themetSe2: trigger-arg-path: interact >prep_with [lemma='mst1'] theme:Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj Gene_or_gene_producttFe2: trigger-arg-path: interact:Binding >prep_with Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk1'] themet e1: args2Role-mention-ngram: cant3e2: trigger-arg-path: interact:Binding >nsubj themet@e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj themet'interceding-token ngrams: RASSF1C ( buttQe2: trigger-arg-path: Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt8e1: trigger-arg-path: bind >dobj [lemma='rassf1a'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk1'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_productt!interceding-token ngrams: RASSF1CtEe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj themetMe1: trigger-arg-path: bind:Binding >nsubj [lemma='cnk1'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mst1'] theme:Gene_or_gene_productt+e2: trigger-arg-path: interact >nsubj themet_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mst1'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubj [lemma='rassf1a'] Gene_or_gene_producttFe2: trigger-arg-path: interact:Binding >prep_with [lemma='mst1'] themet^e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] Gene_or_gene_productt/e1: trigger-arg-path: bind:Binding >nsubj themet8e1: trigger-arg-path: Binding >dobj Gene_or_gene_productt!e1: args2Role-mention-ngram: bindtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1a'] Gene_or_gene_productt'e1: trigger-arg-path: bind >nsubj themet[e2: trigger-arg-path: interact:Binding >prep_with [lemma='mst1'] theme:Gene_or_gene_producttinterceding-token ngrams: )te1: trigger: bindtJe1: trigger-arg-path: Binding >dobj [lemma='rassf1a'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can bindtRe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:Gene_or_gene_productt>e1: trigger-arg-path: Binding >dobj theme:Gene_or_gene_producttFtrigger-to-trigger-path: e1:bind:Binding >conj_and e2:interact:Bindingt%e1: args2Role-mention-ngram: can bindtinterceding-token ngrams: NORE1tYtrigger-to-trigger-path: e1:bind:Binding >conj_and [lemma='interact'] e2:interact:Bindingt&e1: ents2Label-mention-ngram: can bindt^e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Gene_or_gene_productt>interceding-tokens-full-span: or RASSF1C ( but not NORE1 ) andt6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT cantnsubj [lemma='rassf1a'] themetUe1: trigger-arg-path: bind:Binding >dobj [lemma='rassf1a'] theme:Gene_or_gene_producttinterceding-token ngrams: ) andtfe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_productt.e1: trigger-arg-path: bind:Binding >dobj themet>e1: trigger-arg-path: bind:Binding >nsubj [lemma='cnk1'] themetnsubj theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj Gene_or_gene_producttinterceding-token ngrams: butt%interceding-token ngrams: NORE1 ) andt%e2: args2Role-mention-ngram: interacttNe1: trigger-arg-path: Binding >nsubj [lemma='cnk1'] theme:Gene_or_gene_productt>e2: trigger-arg-path: interact >prep_with Gene_or_gene_producttHe2: trigger-arg-path: interact:Binding >nsubj theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: THEME can interactt1e2: ents2Label-mention-ngram: SHARED can interactt_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1a'] theme:Gene_or_gene_productt%interceding-token ngrams: not NORE1 )tOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk1'] themet:e2: trigger-arg-path: interact >nsubj Gene_or_gene_productt=e1: trigger-arg-path: bind:Binding >dobj Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1a'] Gene_or_gene_producttCe2: trigger-arg-path: Binding >prep_with theme:Gene_or_gene_productt'interceding-token ngrams: but not NORE1t+e1: args2Role-mention-ngram: THEME can bindtEe1: trigger-arg-path: bind >nsubj [lemma='cnk1'] Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj [lemma='cnk1'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk1'] Gene_or_gene_producttKe1: trigger-arg-path: bind >nsubj [lemma='cnk1'] theme:Gene_or_gene_productt#interceding-token ngrams: ( but nott'e1: args2Role-mention-ngram: bind THEMEt*e2: args2Role-mention-ngram: interact withtPe1: trigger-arg-path: Binding >dobj [lemma='rassf1a'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='mst1'] Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with themet>e2: trigger-arg-path: interact >prep_with [lemma='mst1'] themet)e1: ents2Label-mention-ngram: bind SHAREDt5e1: trigger-arg-path: bind >dobj Gene_or_gene_producttUe2: trigger-arg-path: interact:Binding >prep_with [lemma='mst1'] Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='mst1'] theme:Gene_or_gene_productt&interceding-token ngrams: or RASSF1C (tCe1: trigger-arg-path: bind:Binding >dobj theme:Gene_or_gene_producttDe2: trigger-arg-path: interact >prep_with theme:Gene_or_gene_productt8e1: trigger-arg-path: lemmatizedTrigger=bind >dobj themet&e2: ents2Label-mention-ngram: interacttMe1: trigger-arg-path: bind >dobj [lemma='rassf1a'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: bindtJe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1a'] themete2: trigger: interactt&e2: args2Role-mention-ngram: THEME cant9e1: trigger-arg-path: Binding >nsubj [lemma='cnk1'] themetZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Gene_or_gene_productt@e2: trigger-arg-path: interact >nsubj theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttZshortest-path: conj_and [lemma='interact'] >nsubj [lemma='rassf1a']tBe2: trigger-arg-path: interact:Binding >nsubj Gene_or_gene_producttinterceding-token ngrams: (t+e1: args2Role-mention-ngram: can bind THEMEtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1a'] themet=e2: trigger-arg-path: Binding >prep_with Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >dobj theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: can interacttPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mst1'] themet+e2: ents2Label-mention-ngram: interact witht!e1: ents2Label-mention-ngram: cant!interceding-token ngrams: NORE1 )t@e2: ents2Label-mention-ngram: interact with GENE_OR_GENE_PRODUCTtDe1: trigger-arg-path: bind:Binding >nsubj theme:Gene_or_gene_productt=e2: trigger-arg-path: interact >nsubj [lemma='rassf1a'] themet&e1: args2Role-mention-ngram: THEME cant-e1: ents2Label-mention-ngram: can bind SHAREDt.e2: args2Role-mention-ngram: can interact withtUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: interact with THEMEtinterceding-token ngrams: ( buttOe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] themete1: incoming: dobj [lemma='rassf1a'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='mst1'] themet&shortest-path: conj_and >nsubjtMe2: trigger-arg-path: interact >prep_with [lemma='mst1'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mst1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with Gene_or_gene_productte2: incoming: dobj theme:Gene_or_gene_producttGe1: trigger-arg-path: bind >dobj [lemma='rassf1a'] Gene_or_gene_productt#interceding-token ngrams: RASSF1C (t=e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj themetLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj Gene_or_gene_producttle2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: complex formation betweent/e2: ents2Label-mention-ngram: binding of SHAREDt5e2: trigger-arg-path: Binding >prep_of >prep_to themetfe2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] Gene_or_gene_productt%e2: args2Role-mention-ngram: THEME tot?e1: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED to SHAREDt(e2: ents2Label-mention-ngram: binding oftinterceding-token ngrams: ist?shortest-path: parataxis [lemma='inhibit'] >agent [lemma='interaction'] >appos [lemma='binding']t,e1: args2Role-mention-ngram: THEME and THEMEt[e2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between theme:Gene_or_gene_producttNe1: trigger-arg-path: complex formation prep_between Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to theme:Gene_or_gene_productt4interceding-token ngrams: intramolecular interactiontMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of Gene_or_gene_productt'interceding-token ngrams: however , thet&e1: args2Role-mention-ngram: formationt>e2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] themet,e2: trigger-arg-path: Binding >prep_of themet"interceding-token ngrams: MAP-1 ist/e1: ents2Label-mention-ngram: formation betweent?e1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between Gene_or_gene_productt>e2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] themet,e1: ents2Label-mention-ngram: between SHAREDtIe2: trigger-arg-path: binding:Binding >prep_of theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of theme:Gene_or_gene_producttWe2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] themet*e2: ents2Label-mention-ngram: of SHARED tot/interceding-token ngrams: interaction , howevertne1: trigger-arg-path: Binding prep_between [lemma='map-1'] theme:Gene_or_gene_productt;e2: trigger-arg-path: binding >prep_of Gene_or_gene_productt.interceding-token ngrams: by an intramoleculart7interceding-token ngrams: an intramolecular interactiontne1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between theme:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] theme:Gene_or_gene_productt4e2: trigger-arg-path: binding:Binding >prep_of themet+e2: args2Role-mention-ngram: THEME to THEMEt)interceding-token ngrams: inhibited by ant4e1: args2Role-mention-ngram: formation between THEMEt,interceding-token ngrams: normally inhibitedt'e2: ents2Label-mention-ngram: SHARED tot,e2: trigger-arg-path: binding >prep_of themetSe2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt&interceding-token ngrams: inhibited bytVe1: trigger-arg-path: complex formation:Binding prep_between Gene_or_gene_producttne2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] themet0e1: ents2Label-mention-ngram: between SHARED andt=e2: trigger-arg-path: binding:Binding >prep_of >prep_to themetce1: trigger-arg-path: complex formation prep_between [lemma='map-1'] themette2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] theme:Gene_or_gene_producttinterceding-token ngrams: ;t>e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of themetJe2: trigger-arg-path: binding >prep_of >prep_to theme:Gene_or_gene_productttrigger-dist: 6tee2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt%interceding-token ngrams: , however ,tue1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] themetge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt&e1: args2Role-mention-ngram: and THEMEtYe1: trigger-arg-path: Binding prep_between [lemma='map-1'] themetle2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] theme:Gene_or_gene_productt/interceding-token ngrams: normally inhibited bytOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to themet.e1: args2Role-mention-ngram: complex formationtqe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] themetDe2: trigger-arg-path: binding >prep_of >prep_to Gene_or_gene_productt'e1: ents2Label-mention-ngram: formationt?e1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] themetGe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to themet?e1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] Gene_or_gene_productt?e1: trigger-arg-path: complex formation prep_between themetxe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] themetde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to theme:Gene_or_gene_producttGe1: trigger-arg-path: complex formation:Binding prep_between themet;e2: trigger-arg-path: Binding >prep_of Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] themet5e2: trigger-arg-path: binding >prep_of >prep_to themet(e2: args2Role-mention-ngram: of THEME tot$interceding-token ngrams: ; MAP-1 ist"interceding-token ngrams: normallytFe2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] themetlinterceding-tokens-full-span: ; MAP-1 is normally inhibited by an intramolecular interaction , however , thetDe1: trigger-arg-path: Binding prep_between Gene_or_gene_productt%e2: ents2Label-mention-ngram: bindingt_e2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] themet5e1: trigger-arg-path: Binding prep_between themet|e1: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] Gene_or_gene_productt$e1: args2Role-mention-ngram: complext?e1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binding:Binding >prep_of >prep_to Gene_or_gene_producttpe1: trigger-arg-path: Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt!interceding-token ngrams: ; MAP-1tie2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] themet!interceding-token ngrams: howevertinterceding-token ngrams: byt-e2: args2Role-mention-ngram: binding of THEMEtxe1: trigger-arg-path: complex formation prep_between [lemma='map-1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] Gene_or_gene_producttMe2: trigger-arg-path: binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: formation between SHAREDtSe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of theme:Gene_or_gene_productt'interceding-token ngrams: interaction ,tze1: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] Gene_or_gene_productt%interceding-token ngrams: is normallyt7e1: ents2Label-mention-ngram: complex formation betweent%interceding-token ngrams: interactiont#interceding-token ngrams: , howevert[e1: trigger-arg-path: Binding prep_between [lemma='rassf1a'] themet\e1: trigger-arg-path: complex formation:Binding prep_between theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding prep_between theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of themetDe2: trigger-arg-path: Binding >prep_of >prep_to Gene_or_gene_productt.e1: args2Role-mention-ngram: formation betweentinterceding-token ngrams: , thet+interceding-token ngrams: MAP-1 is normallytinterceding-token ngrams: MAP-1tutrigger-to-trigger-path: e1:complex formation:Binding parataxis >agent >appos e2:binding:Bindingtje1: trigger-arg-path: Binding prep_between [lemma='rassf1a'] Gene_or_gene_producttTe1: trigger-arg-path: complex formation prep_between theme:Gene_or_gene_producttre1: trigger-arg-path: complex formation prep_between [lemma='map-1'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_of >prep_to theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between themet$e2: args2Role-mention-ngram: bindingt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: complext^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to Gene_or_gene_producttinterceding-token ngrams: by ant#interceding-token ngrams: however ,t?trigger-to-trigger-path: e1:complex formation:Binding parataxis [lemma='inhibit'] >agent [lemma='interaction'] >appos [lemma='binding'] e2:binding:Bindingte2: trigger: bindingtAe2: trigger-arg-path: binding >prep_of theme:Gene_or_gene_producttfe2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_producttAe2: trigger-arg-path: Binding >prep_of theme:Gene_or_gene_productt+interceding-token ngrams: an intramoleculartMe2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: SHARED andte1: trigger: complex formationthe1: trigger-arg-path: Binding prep_between [lemma='map-1'] Gene_or_gene_productt(interceding-token ngrams: intramoleculart;shortest-path: parataxis >agent >appost/interceding-token ngrams: is normally inhibitedtVe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: complex formationtke1: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] themetUe2: trigger-arg-path: binding:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of Gene_or_gene_producttte1: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] Gene_or_gene_producttee1: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] themet6interceding-token ngrams: intramolecular interaction ,tCe2: trigger-arg-path: binding:Binding >prep_of Gene_or_gene_producttRe2: trigger-arg-path: binding:Binding >prep_of >prep_to theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: binding oftWe2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_to [lemma='map-1'] themetwe1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] themetme1: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] themet?e1: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED and SHAREDt_e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rassf1a'] Gene_or_gene_producttze1: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt_e1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] themetze2: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between themetae1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet+e1: ents2Label-mention-ngram: of SHARED andt*e2: args2Role-mention-ngram: between THEMEt)e1: args2Role-mention-ngram: modulator oftKe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of themet%e2: ents2Label-mention-ngram: betweentQe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of themet&e2: args2Role-mention-ngram: formationtxe2: trigger-arg-path: complex formation prep_between [lemma='map-1'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] Gene_or_gene_productt!interceding-token ngrams: MAP-1 )t`e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between Gene_or_gene_productt'interceding-token ngrams: complexes andte1: trigger: recruitmentt)interceding-token ngrams: to the receptort?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] Gene_or_gene_productt.e2: args2Role-mention-ngram: complex formationt0interceding-token ngrams: the receptor complexest?e2: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] themet?e1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_producttpe2: trigger-arg-path: Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_producttPe1: trigger-arg-path: recruitment:Binding >prep_of >prep_of Gene_or_gene_productt$e2: args2Role-mention-ngram: betweent interceding-token ngrams: to thetSe1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt"interceding-token ngrams: promotedtie1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themetNe2: trigger-arg-path: complex formation prep_between Gene_or_gene_productt)e1: ents2Label-mention-ngram: recruitmentt0interceding-token ngrams: complexes and promotedt1e1: args2Role-mention-ngram: recruitment of THEMEt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] theme:Gene_or_gene_productt6e2: args2Role-mention-ngram: complex formation betweent9e1: trigger-arg-path: recruitment >prep_of >prep_of themet,e2: ents2Label-mention-ngram: between SHAREDt!interceding-token ngrams: ( MAP-1t/e2: ents2Label-mention-ngram: complex formationtYe2: trigger-arg-path: Binding prep_between [lemma='map-1'] themet&interceding-token ngrams: and promotedt.e2: args2Role-mention-ngram: between THEME andtVe2: trigger-arg-path: complex formation:Binding prep_between Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet|e2: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] Gene_or_gene_producttGe1: trigger-arg-path: recruitment:Binding >prep_of Gene_or_gene_productt)e1: args2Role-mention-ngram: of THEME andt*interceding-token ngrams: MAP-1 ) proteinst.e2: args2Role-mention-ngram: formation betweentre2: trigger-arg-path: complex formation prep_between [lemma='map-1'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] themetze2: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] theme:Gene_or_gene_producttje2: trigger-arg-path: Binding prep_between [lemma='rassf1a'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: recruitment of SHAREDtxe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productttshortest-path: conj_and [lemma='promote'] >dobj [lemma='formation'] >nn [lemma='complex']tSe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of themetYe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_producttJe2: trigger-arg-path: Binding prep_between theme:Gene_or_gene_productt7e2: ents2Label-mention-ngram: complex formation betweent`e1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of theme:Gene_or_gene_producttQe1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] Gene_or_gene_productt'interceding-token ngrams: ) proteins totWe1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productte2: trigger: complex formationtse1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themetee2: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] themet*e1: ents2Label-mention-ngram: modulator oft+e1: ents2Label-mention-ngram: and modulatortWinterceding-tokens-full-span: ( MAP-1 ) proteins to the receptor complexes and promotedt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: SHARED and modulatorte2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] themet~e1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_producttTe2: trigger-arg-path: complex formation prep_between theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: recruitmenttqe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_producttJe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] themetQe2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between themetpe1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt0e1: trigger-arg-path: recruitment >prep_of themet)interceding-token ngrams: proteins to thet,interceding-token ngrams: receptor complexest0e2: ents2Label-mention-ngram: between SHARED andtce2: trigger-arg-path: complex formation prep_between [lemma='map-1'] themet5e1: trigger-arg-path: Binding >prep_of >prep_of themet"interceding-token ngrams: proteinst/e1: args2Role-mention-ngram: modulator of THEMEtne2: trigger-arg-path: Binding prep_between [lemma='map-1'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: formation betweentbe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of Gene_or_gene_productt+shortest-path: conj_and >dobj >nnt.e1: ents2Label-mention-ngram: and modulator oftre1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: recruitment oft"interceding-token ngrams: receptort&e1: args2Role-mention-ngram: modulatort4e2: args2Role-mention-ngram: formation between THEMEtBe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of themetle1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt8e1: trigger-arg-path: recruitment:Binding >prep_of themetBe1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] themet\e2: trigger-arg-path: complex formation:Binding prep_between theme:Gene_or_gene_productt]e1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet?e2: trigger-arg-path: complex formation prep_between themethe2: trigger-arg-path: Binding prep_between [lemma='map-1'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_of >prep_of theme:Gene_or_gene_producttte2: trigger-arg-path: complex formation prep_between [lemma='rassf1a'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt#interceding-token ngrams: ( MAP-1 )tYe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of Gene_or_gene_productt%interceding-token ngrams: proteins totke1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt?e1: ents2Label-mention-ngram: modulator of GENE_OR_GENE_PRODUCTtEe1: trigger-arg-path: recruitment >prep_of theme:Gene_or_gene_producttGe2: trigger-arg-path: complex formation:Binding prep_between themetue2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] themetAe1: trigger-arg-path: recruitment:Binding >prep_of >prep_of themet#interceding-token ngrams: complexestve1: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of theme:Gene_or_gene_productt0interceding-token ngrams: receptor complexes andt?e1: trigger-arg-path: recruitment >prep_of Gene_or_gene_productt[e2: trigger-arg-path: Binding prep_between [lemma='rassf1a'] themetDe2: trigger-arg-path: Binding prep_between Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: formation between SHAREDt?trigger-to-trigger-path: e1:recruitment:Binding conj_and [lemma='promote'] >dobj [lemma='formation'] >nn [lemma='complex'] e2:complex formation:Bindingt>e1: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] themet-e1: args2Role-mention-ngram: and modulator oftNe1: trigger-arg-path: recruitment >prep_of >prep_of theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between theme:Gene_or_gene_producttme2: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] themetHe1: trigger-arg-path: recruitment >prep_of >prep_of Gene_or_gene_productt5e2: trigger-arg-path: Binding prep_between themetMe1: trigger-arg-path: recruitment:Binding >prep_of theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: formationthe2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='rassf1a'] Gene_or_gene_productt*e1: args2Role-mention-ngram: and modulatortfe2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: THEME and modulatort&interceding-token ngrams: the receptortVe1: trigger-arg-path: recruitment:Binding >prep_of >prep_of theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: recruitment oft?e2: trigger-arg-path: complex formation:Binding prep_between [lemma='rassf1a'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_producttDe1: trigger-arg-path: Binding >prep_of >prep_of Gene_or_gene_producttke2: trigger-arg-path: complex formation:Binding prep_between [lemma='map-1'] themet'e1: ents2Label-mention-ngram: modulatort}e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='map-1'] themethe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of theme:Gene_or_gene_producttitrigger-to-trigger-path: e1:recruitment:Binding conj_and >dobj >nn e2:complex formation:Bindingt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='map-1'] theme:Gene_or_gene_productt$interceding-token ngrams: ) proteinst4interceding-token ngrams: promoted complex formationt{shortest-path: parataxis [lemma='inhibit'] >agent [lemma='interaction'] >appos [lemma='binding']t!interceding-token ngrams: complext+interceding-token ngrams: complex formationt!interceding-token ngrams: MAP-1 ;t+interceding-token ngrams: RASSF1A and MAP-1t'interceding-token ngrams: MAP-1 ; MAP-1tparataxis >agent >appos e2:binding:Bindingt!interceding-token ngrams: betweent)interceding-token ngrams: between RASSF1At+interceding-token ngrams: formation betweent.interceding-token ngrams: and promoted complext*interceding-token ngrams: promoted complext!interceding-token ngrams: RASSF1At?trigger-to-trigger-path: e1:recruitment:Binding parataxis [lemma='inhibit'] >agent [lemma='interaction'] >appos [lemma='binding'] e2:binding:Bindingt-interceding-token ngrams: between RASSF1A andt%interceding-token ngrams: RASSF1A andt#interceding-token ngrams: and MAP-1t3interceding-token ngrams: formation between RASSF1At3interceding-token ngrams: complex formation betweent0shortest-path: parataxis >agent >appost@e1: trigger-arg-path: binding >poss [lemma='its'] Generic_entityt0e2: args2Role-mention-ngram: tyrosine CONTROLLEDt)e2: ents2Label-mention-ngram: IGF or PDGFt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='shp-2'] themet,e1: ents2Label-mention-ngram: SHARED bindingt!e2: ents2Label-mention-ngram: butt@e1: trigger-arg-path: Binding >poss [lemma='its'] Generic_entityt e2: args2Role-mention-ngram: IGFt?e1: trigger-arg-path: binding:Binding prep_to [lemma='shp-2'] themet e2: args2Role-mention-ngram: ledtNe1: trigger-arg-path: binding:Binding >poss [lemma='its'] theme:Generic_entityt'e2: args2Role-mention-ngram: PDGF , ledtSe2: trigger-arg-path: lemmatizedTrigger=lead >nsubj controller:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME bindingt%e2: ents2Label-mention-ngram: to botht-e1: args2Role-mention-ngram: binding to THEMEtinterceding-tokens-full-span: .te2: trigger: ledt$e2: ents2Label-mention-ngram: PDGF ,tRe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss theme:Generic_entitytPe1: trigger-arg-path: lemmatizedTrigger=binding prep_to themet-e2: args2Role-mention-ngram: CONTROLLER , butt/e1: ents2Label-mention-ngram: SHARED binding tot5e2: ents2Label-mention-ngram: both increased tyrosinet'e2: ents2Label-mention-ngram: or PDGF ,tWe2: trigger-arg-path: led:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: not IGFtFe1: trigger-arg-path: Binding >poss [lemma='its'] theme:Generic_entitytXe1: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] theme:Generic_entitytXe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themet+e2: trigger-arg-path: led >nsubj controllert&e2: args2Role-mention-ngram: or PDGF ,t?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='shp-2'] themetNe2: trigger-arg-path: led >nsubj [lemma='egf'] controller:Gene_or_gene_producttCe2: trigger-arg-path: led >nsubj [lemma='egf'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj controller:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=binding >poss theme:Generic_entityt:e2: args2Role-mention-ngram: increased tyrosine CONTROLLEDt#e2: args2Role-mention-ngram: led tot+e2: args2Role-mention-ngram: both increasedt%e2: args2Role-mention-ngram: , led tot\e2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj Gene_or_gene_productt,e2: ents2Label-mention-ngram: both increasedt0e2: ents2Label-mention-ngram: increased tyrosinet e2: args2Role-mention-ngram: butt"e2: args2Role-mention-ngram: , ledtee1: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_producttSe1: trigger-arg-path: binding prep_to theme:Gene_or_gene_productt@e1: trigger-arg-path: binding:Binding >poss theme:Generic_entitytTe2: trigger-arg-path: led:Positive_regulation >nsubj controller:Gene_or_gene_productt#e2: ents2Label-mention-ngram: , ledt(e2: args2Role-mention-ngram: IGF or PDGFtVe2: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='egf'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_productt(e2: ents2Label-mention-ngram: not IGF ort$e2: args2Role-mention-ngram: to botht/e2: args2Role-mention-ngram: increased tyrosinet)e2: ents2Label-mention-ngram: led to bothte2: args2Role-mention-ngram: ,t8e1: trigger-arg-path: Binding >poss theme:Generic_entityt?e1: trigger-arg-path: binding:Binding >poss [lemma='its'] themet'e2: args2Role-mention-ngram: not IGF ortZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] Generic_entityt(e1: ents2Label-mention-ngram: binding tot(CSSPATH: ROOT >prep_on >prep_of ++ ROOT t)e2: ents2Label-mention-ngram: but not IGFt?e1: trigger-arg-path: Binding prep_to [lemma='shp-2'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: but notte1: incoming: nsubj [lemma='egf'] controllertHe1: trigger-arg-path: binding:Binding >poss [lemma='its'] Generic_entityt2e1: trigger-arg-path: binding >poss Generic_entityt"e2: ents2Label-mention-ngram: bothtLe2: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='egf'] controllertme1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: , led tot7e1: trigger-arg-path: binding >poss [lemma='its'] themet.e2: args2Role-mention-ngram: to both increasedt"e2: args2Role-mention-ngram: , butt@e2: ents2Label-mention-ngram: increased tyrosine phosphorylationt[e1: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='shp-2'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binding prep_to Gene_or_gene_productt2e1: trigger-arg-path: Binding >poss Generic_entityt)e1: trigger-arg-path: Binding >poss themete2: ents2Label-mention-ngram: ,t-e1: args2Role-mention-ngram: THEME binding tot#e2: ents2Label-mention-ngram: , buttae2: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='egf'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: binding tot`e2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='egf'] controllert1e1: trigger-arg-path: binding:Binding >poss themet?e1: trigger-arg-path: binding:Binding prep_to [lemma='shp-2'] Gene_or_gene_productt$e2: args2Role-mention-ngram: not IGFt(e2: args2Role-mention-ngram: led to bothtje2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt@e2: trigger-arg-path: led >nsubj controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: PDGFt?e1: trigger-arg-path: Binding prep_to [lemma='shp-2'] theme:Gene_or_gene_productt5e2: trigger-arg-path: led >nsubj Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='shp-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding prep_to [lemma='shp-2'] theme:Gene_or_gene_producttIe2: trigger-arg-path: led:Positive_regulation >nsubj Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] theme:Generic_entityt>e1: trigger-arg-path: binding prep_to themet(e2: args2Role-mention-ngram: but not IGFt%e2: args2Role-mention-ngram: tyrosinetIe1: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] themet/e2: ents2Label-mention-ngram: to both increasedtxe1: trigger-arg-path: binding prep_to [lemma='shp-2'] themetinterceding-token ngrams: .tQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] themet!e2: ents2Label-mention-ngram: IGFt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='shp-2'] Gene_or_gene_productt4e2: args2Role-mention-ngram: both increased tyrosinet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='shp-2'] theme:Gene_or_gene_productt9e2: trigger-arg-path: led >nsubj [lemma='egf'] controllert?e2: trigger-arg-path: led:Positive_regulation >nsubj controllert$e2: args2Role-mention-ngram: but nott=e1: ents2Label-mention-ngram: binding to GENE_OR_GENE_PRODUCTt%e2: ents2Label-mention-ngram: or PDGFt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='shp-2'] Gene_or_gene_producttSe1: trigger-arg-path: Binding prep_to theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: tyrosine phosphorylationtUe1: trigger-arg-path: binding:Binding prep_to Gene_or_gene_productt$e2: ents2Label-mention-ngram: IGF ort#e2: args2Role-mention-ngram: IGF ort?e1: trigger-arg-path: binding prep_to [lemma='shp-2'] theme:Gene_or_gene_producttxe1: trigger-arg-path: Binding prep_to [lemma='shp-2'] themet4e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ,t>e1: trigger-arg-path: Binding prep_to themet e2: ents2Label-mention-ngram: ort&e2: args2Role-mention-ngram: , but nott:e1: trigger-arg-path: binding:Binding >poss Generic_entityt'e2: ents2Label-mention-ngram: , but nott;e1: trigger-arg-path: lemmatizedTrigger=binding >poss themet&e2: ents2Label-mention-ngram: tyrosinet"e2: ents2Label-mention-ngram: PDGFtMe1: trigger-arg-path: Binding prep_to Gene_or_gene_productt8e1: trigger-arg-path: binding >poss theme:Generic_entityt>e2: trigger-arg-path: lemmatizedTrigger=lead >nsubj controllertDe1: trigger-arg-path: lemmatizedTrigger=binding >poss Generic_entityt'e2: ents2Label-mention-ngram: increasedt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , butt)e1: trigger-arg-path: binding >poss themet9e2: ents2Label-mention-ngram: tyrosine phosphorylation oftHe2: trigger-arg-path: lemmatizedTrigger=lead >nsubj Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss themet!e2: ents2Label-mention-ngram: ledt&e2: args2Role-mention-ngram: increasedte1: THEME: 3tRe1: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] Generic_entityt$e2: args2Role-mention-ngram: or PDGFtFe1: trigger-arg-path: binding >poss [lemma='its'] theme:Generic_entitytRe2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj controllerte2: args2Role-mention-ngram: ortcross-sent:truetFe1: trigger-arg-path: binding:Binding prep_to themet$e2: ents2Label-mention-ngram: led tot)e2: args2Role-mention-ngram: CONTROLLER ,tbe2: trigger-arg-path: led:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: PDGF , ledtLe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss Generic_entityt7e1: trigger-arg-path: Binding >poss [lemma='its'] themet!e2: args2Role-mention-ngram: botht,interceding-token ngrams: EGF stimulation oft?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controllertpe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_productt&interceding-token ngrams: after strongt interceding-token ngrams: 20 h ;t?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlledt&e1: args2Role-mention-ngram: increasedtNe2: trigger-arg-path: block:Negative_activation >dobj >nn Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >nn controlledt1e1: args2Role-mention-ngram: SHP-2 overexpressiont0e2: trigger-arg-path: block >dobj >nn controlledt+e1: args2Role-mention-ngram: overexpressiont]e1: trigger-arg-path: prolonged:Positive_regulation >dobj >prep_of controlled:Phosphorylationtnsubj [lemma='shp-2'] controllert%interceding-token ngrams: stimulationt(interceding-token ngrams: medium withoutt-interceding-token ngrams: , dominant negativet7e1: ents2Label-mention-ngram: prolonged the persistencet^e2: trigger-arg-path: block >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: increased SHARED phosphorylationtie1: trigger-arg-path: prolonged >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlledt.interceding-token ngrams: initially in minimalt'e1: ents2Label-mention-ngram: prolongedtde2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj Gene_or_gene_productt interceding-token ngrams: mutanttfe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >nn [lemma='mapk'] controlledt7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT failt'e1: ents2Label-mention-ngram: increasedt&interceding-token ngrams: proteins didtqe1: trigger-arg-path: prolonged:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controllert-e2: args2Role-mention-ngram: block CONTROLLEDt+interceding-token ngrams: in minimal mediumt%interceding-token ngrams: factors fortNe1: trigger-arg-path: lemmatizedTrigger=prolong >dobj >prep_of Phosphorylationt interceding-token ngrams: growthtae2: trigger-arg-path: Negative_activation nsubj [lemma='shp-2'] controllert?interceding-tokens-full-span: after strong EGF stimulation of cells grown initially in minimal medium without growth factors for 20 h ; mutant Gab1 and SHP-2 proteins did not . Interestingly , dominant negative Gab1 andt"interceding-token ngrams: Gab1 andt interceding-token ngrams: mediumt(interceding-token ngrams: growth factorst*e2: args2Role-mention-ngram: fail to blockt2interceding-token ngrams: Interestingly , dominantt)interceding-token ngrams: EGF stimulationt%e2: ents2Label-mention-ngram: fail tothe2: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledt?e1: trigger-arg-path: prolonged:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt9e1: args2Role-mention-ngram: overexpression prolonged thetZe1: trigger-arg-path: lemmatizedTrigger=prolong >nsubj >nn controller:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=block >dobj >nn Gene_or_gene_productt;e1: args2Role-mention-ngram: SHP-2 overexpression prolongedtIe2: trigger-arg-path: block nsubj controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=block nsubj controller:Gene_or_gene_productt"interceding-token ngrams: of cellstqe2: trigger-arg-path: block:Negative_activation nsubj [lemma='shp-2'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=prolong >nsubj [lemma='overexpression'] >nn [lemma='gab1'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: and SHP-2 overexpressiont)e1: args2Role-mention-ngram: of increasedtSe1: trigger-arg-path: Positive_regulation >dobj >prep_of controlled:Phosphorylationt/interceding-token ngrams: cells grown initiallyt)interceding-token ngrams: . Interestinglyt"interceding-token ngrams: ; mutanttce1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj >nn Gene_or_gene_productt0interceding-token ngrams: minimal medium withoutt(interceding-token ngrams: minimal mediumtze2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledt,interceding-token ngrams: and SHP-2 proteinstme1: trigger-arg-path: lemmatizedTrigger=prolong >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controllert?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationthe2: trigger-arg-path: block nsubj [lemma='shp-2'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj >nn controllert?e1: trigger-arg-path: prolonged >nsubj >nn Gene_or_gene_productt^e1: trigger-arg-path: prolonged:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt]e2: trigger-arg-path: block:Negative_activation nsubj controller:Gene_or_gene_productt'interceding-token ngrams: negative Gab1t0e2: args2Role-mention-ngram: to block CONTROLLEDtge1: trigger-arg-path: prolonged >nsubj [lemma='overexpression'] >nn [lemma='gab1'] Gene_or_gene_producttHe1: trigger-arg-path: Positive_regulation >dobj >prep_of Phosphorylationtge1: trigger-arg-path: Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controllertbe2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledtze2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='shp-2'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=prolong >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: failt"e2: args2Role-mention-ngram: blockt+e2: ents2Label-mention-ngram: fail to blockt5e1: args2Role-mention-ngram: and SHP-2 overexpressiont|e2: trigger-arg-path: block:Negative_activation nsubj [lemma='shp-2'] controller:Gene_or_gene_producttwe2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_productt0interceding-token ngrams: without growth factorstinterceding-token ngrams: ht{e1: trigger-arg-path: prolonged:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj controllertne1: trigger-arg-path: prolonged >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] Phosphorylationt/e2: args2Role-mention-ngram: CONTROLLER fail tot!interceding-token ngrams: withouttCe1: trigger-arg-path: Positive_regulation >dobj >prep_of controlledt9e1: trigger-arg-path: prolonged >dobj >prep_of controlledt?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] PhosphorylationtRe2: trigger-arg-path: block:Negative_activation nsubj Gene_or_gene_productt(interceding-token ngrams: without growtht#e2: ents2Label-mention-ngram: blockt(interceding-token ngrams: of cells grownt5e1: trigger-arg-path: prolonged >nsubj >nn controllert4e2: trigger-arg-path: block nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=prolong >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlled:PhosphorylationtIe1: trigger-arg-path: prolonged >dobj >prep_of controlled:Phosphorylationt|e1: trigger-arg-path: Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controller:Gene_or_gene_productt+interceding-token ngrams: . Interestingly ,tHe2: trigger-arg-path: block:Negative_activation nsubj controllert+e1: ents2Label-mention-ngram: prolonged thet'interceding-token ngrams: Interestinglyt,e1: ents2Label-mention-ngram: overexpressiont+e1: args2Role-mention-ngram: persistence oftoe2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='shp-2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: the persistence oftSe1: trigger-arg-path: prolonged:Positive_regulation >nsubj >nn Gene_or_gene_productt$interceding-token ngrams: in minimalt,interceding-token ngrams: SHP-2 proteins didt,interceding-token ngrams: growth factors fort%e2: args2Role-mention-ngram: to blockt(interceding-token ngrams: SHP-2 proteinstinterceding-token ngrams: SHP-2t?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_producttre1: trigger-arg-path: prolonged >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: CONTROLLER andtye1: trigger-arg-path: prolonged >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt6e1: ents2Label-mention-ngram: overexpression prolongedt&e1: args2Role-mention-ngram: and SHP-2tbe1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj >prep_of Phosphorylationt?e1: trigger-arg-path: Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt)interceding-token ngrams: grown initiallytme1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj >prep_of controlled:Phosphorylationtxe1: trigger-arg-path: Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] Phosphorylationt#interceding-token ngrams: initiallytke2: trigger-arg-path: Negative_activation nsubj [lemma='shp-2'] Gene_or_gene_productt6e1: args2Role-mention-ngram: prolonged the persistencetRe1: trigger-arg-path: prolonged:Positive_regulation >dobj >prep_of Phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >dobj >prep_of controlledt?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj [lemma='shp-2'] Gene_or_gene_productt$interceding-token ngrams: strong EGFtinterceding-token ngrams: Gab1tinterceding-token ngrams: 20tqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] Gene_or_gene_productt*interceding-token ngrams: after strong EGFt?e1: trigger-arg-path: prolonged:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] PhosphorylationtMe1: trigger-arg-path: prolonged:Positive_regulation >dobj >prep_of controlledtinterceding-token ngrams: h ;tinterceding-token ngrams: EGFtJe1: trigger-arg-path: prolonged >nsubj >nn controller:Gene_or_gene_productt:e2: trigger-arg-path: block >dobj >nn Gene_or_gene_productt$e2: args2Role-mention-ngram: fail tot{e2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_productt>e2: trigger-arg-path: block nsubj Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=prolong >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] Phosphorylationt>e1: trigger-arg-path: prolonged >dobj >prep_of Phosphorylationt5e1: args2Role-mention-ngram: overexpression prolongedt interceding-token ngrams: strongtke2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >nn controlled:Gene_or_gene_producttWe2: trigger-arg-path: Negative_activation nsubj controller:Gene_or_gene_productt)interceding-token ngrams: mutant Gab1 andt+interceding-token ngrams: negative Gab1 andt"interceding-token ngrams: for 20 ht)interceding-token ngrams: Interestingly ,tOe1: trigger-arg-path: lemmatizedTrigger=prolong >nsubj >nn Gene_or_gene_productt-interceding-token ngrams: not . Interestinglyt*e1: ents2Label-mention-ngram: of increasedt,e1: args2Role-mention-ngram: the persistencet1e1: args2Role-mention-ngram: increased CONTROLLEDt'e1: ents2Label-mention-ngram: and SHP-2t0e1: ents2Label-mention-ngram: the persistence oft$interceding-token ngrams: , dominanttinterceding-token ngrams: cellste1: trigger: prolongedtinterceding-token ngrams: not .tBe2: trigger-arg-path: Negative_activation nsubj controllert(interceding-token ngrams: stimulation oft+interceding-token ngrams: dominant negativet#interceding-token ngrams: and SHP-2tinterceding-token ngrams: 20 htWe2: trigger-arg-path: lemmatizedTrigger=block >dobj >nn controlled:Gene_or_gene_productt1e1: ents2Label-mention-ngram: of increased SHAREDt0interceding-token ngrams: dominant negative Gab1t?e1: trigger-arg-path: prolonged:Positive_regulation >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: persistencet,e2: args2Role-mention-ngram: CONTROLLER failt"interceding-token ngrams: negativet#e1: ents2Label-mention-ngram: SHP-2t(interceding-token ngrams: Gab1 and SHP-2t"e1: args2Role-mention-ngram: SHP-2t`e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >nn Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=prolong:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttEe2: trigger-arg-path: block >dobj >nn controlled:Gene_or_gene_productt4e1: args2Role-mention-ngram: of increased CONTROLLEDtnsubj >nn controllert*interceding-token ngrams: proteins did nott]e2: trigger-arg-path: block nsubj [lemma='shp-2'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: failtve2: trigger-arg-path: Negative_activation nsubj [lemma='shp-2'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER and SHP-2tDe2: trigger-arg-path: block:Negative_activation >dobj >nn controlledtBe2: trigger-arg-path: lemmatizedTrigger=block >dobj >nn controlledtinterceding-token ngrams: grownt]e1: trigger-arg-path: prolonged >nsubj [lemma='overexpression'] >nn [lemma='gab1'] controllertCSSPATH: ROOT  ++ ROOT >xcompt:e1: ents2Label-mention-ngram: overexpression prolonged thete2: trigger: blocktye2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj [lemma='shp-2'] controllertLe2: trigger-arg-path: Negative_activation nsubj Gene_or_gene_productt,e1: ents2Label-mention-ngram: persistence oftye1: trigger-arg-path: lemmatizedTrigger=prolong >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlledtPe2: trigger-arg-path: lemmatizedTrigger=block nsubj Gene_or_gene_productt$interceding-token ngrams: h ; mutantt&e2: ents2Label-mention-ngram: to blocktinterceding-token ngrams: aftertre2: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_productt/interceding-token ngrams: medium without growtht*e1: args2Role-mention-ngram: prolonged thetFe2: trigger-arg-path: lemmatizedTrigger=block nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_productt"interceding-token ngrams: dominantt.interceding-token ngrams: stimulation of cellstIe1: trigger-arg-path: prolonged:Positive_regulation >nsubj >nn controllert&e1: args2Role-mention-ngram: prolongedt2e1: ents2Label-mention-ngram: SHP-2 overexpressiont(interceding-token ngrams: factors for 20t0interceding-token ngrams: strong EGF stimulationtge2: trigger-arg-path: block:Negative_activation nsubj [lemma='shp-2'] controllert6e1: ents2Label-mention-ngram: persistence of increasedt&interceding-token ngrams: initially intYe1: trigger-arg-path: lemmatizedTrigger=prolong >dobj >prep_of controlled:Phosphorylationt%interceding-token ngrams: cells grownt#interceding-token ngrams: did not .t*e2: ents2Label-mention-ngram: block SHAREDtse1: trigger-arg-path: Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlledt-e2: ents2Label-mention-ngram: to block SHAREDtoe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation nsubj [lemma='shp-2'] controller:Gene_or_gene_productt!interceding-token ngrams: factorst,interceding-token ngrams: grown initially int.e1: ents2Label-mention-ngram: increased SHAREDt}e2: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_producttinterceding-token ngrams: fortYe2: trigger-arg-path: block:Negative_activation >dobj >nn controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: persistencet-e1: ents2Label-mention-ngram: the persistencet!interceding-token ngrams: did nott!interceding-token ngrams: minimalt%interceding-token ngrams: mutant Gab1t:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT fail totIe1: trigger-arg-path: lemmatizedTrigger=prolong >dobj >prep_of controlledt}e1: trigger-arg-path: prolonged:Positive_regulation >dobj [lemma='persistence'] >prep_of [lemma='phosphorylation'] controlledtie2: trigger-arg-path: block >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='shp-2'] controllertle2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_productt5e1: args2Role-mention-ngram: persistence of increasedtTe2: trigger-arg-path: block >dobj [lemma='activation'] >nn [lemma='mapk'] controlledt1e2: args2Role-mention-ngram: CONTROLLER and SHP-2tHe2: trigger-arg-path: Positive_activation >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledtfe2: trigger-arg-path: block:Positive_activation nsubj [lemma='gab1'] controllert+e2: ents2Label-mention-ngram: SHP-2 fail totYe2: trigger-arg-path: block:Positive_activation >dobj >nn controlled:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >nn Gene_or_gene_producttBe2: trigger-arg-path: Positive_activation nsubj controllertue2: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED and SHP-2t{e2: trigger-arg-path: block:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledtxe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj [lemma='gab1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: and SHP-2tWe2: trigger-arg-path: Positive_activation nsubj controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >nn controlledt&e2: args2Role-mention-ngram: and SHP-2tje2: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] Gene_or_gene_productt+e2: args2Role-mention-ngram: and SHP-2 failt,e2: ents2Label-mention-ngram: and SHP-2 failtde2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='gab1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_producttNe2: trigger-arg-path: block:Positive_activation >dobj >nn Gene_or_gene_productt`e2: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] controllert?interceding-tokens-full-span: after strong EGF stimulation of cells grown initially in minimal medium without growth factors for 20 h ; mutant Gab1 and SHP-2 proteins did not . Interestingly , dominant negativet}e2: trigger-arg-path: block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >nn controlled:Gene_or_gene_productt\e2: trigger-arg-path: block nsubj [lemma='gab1'] Gene_or_gene_productt'e2: args2Role-mention-ngram: SHP-2 failt>e2: trigger-arg-path: Positive_activation >dobj >nn controlledt.e1: ents2Label-mention-ngram: SHARED and SHP-2toe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: SHP-2 failtHe2: trigger-arg-path: block:Positive_activation nsubj controllertSe2: trigger-arg-path: Positive_activation >dobj >nn controlled:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='gab1'] Gene_or_gene_producttRe2: trigger-arg-path: block:Positive_activation nsubj Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='gab1'] controller:Gene_or_gene_producttre2: trigger-arg-path: block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_producttge2: trigger-arg-path: block nsubj [lemma='gab1'] controller:Gene_or_gene_productt]e2: trigger-arg-path: block:Positive_activation nsubj controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj controllertDe2: trigger-arg-path: block:Positive_activation >dobj >nn controlledt"e2: args2Role-mention-ngram: SHP-2tRe2: trigger-arg-path: block nsubj [lemma='gab1'] controllertLe2: trigger-arg-path: Positive_activation nsubj Gene_or_gene_productt*e2: args2Role-mention-ngram: SHP-2 fail tothe2: trigger-arg-path: block:Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlledtle2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: SHP-2t?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_producttpe2: trigger-arg-path: block:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_producttwe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='mapk'] controlled:Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='p190'] themet=e1: trigger-arg-path: association:Binding >prep_between themet(interceding-token ngrams: independent oft$interceding-token ngrams: regulationtOe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between themetGe1: trigger-arg-path: lemmatizedTrigger=association >prep_between themetve1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_producttLe1: trigger-arg-path: association:Binding >prep_between [lemma='p190'] themetbe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_productt-interceding-token ngrams: the phosphotyrosinet)interceding-token ngrams: phosphotyrosinet*interceding-token ngrams: , independent oftHe2: trigger-arg-path: complex >nn [lemma='ras-gap'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_productt:CSSPATH: ROOT >prep_on ++ ROOT >nsubj >prep_of >vmod >dobjt+interceding-token ngrams: of Ras regulationtDe1: trigger-arg-path: association >prep_between [lemma='p190'] themet6interceding-token ngrams: the phosphotyrosine mediatedt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='p190'] theme:Gene_or_gene_productt5e1: trigger-arg-path: association >prep_between themetVe1: trigger-arg-path: association >prep_between [lemma='ras-gap'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED complext6e2: trigger-arg-path: complex >nn [lemma='p190'] themetHe2: trigger-arg-path: Binding >nn [lemma='ras-gap'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] themet(e1: args2Role-mention-ngram: associationtZe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] Gene_or_gene_productt2interceding-token ngrams: phosphotyrosine mediatedtKe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] themetde1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=association >prep_between Gene_or_gene_productt6e1: args2Role-mention-ngram: association between THEMEt/e2: ents2Label-mention-ngram: SHARED and SHAREDtNe2: trigger-arg-path: complex >nn [lemma='ras-gap'] theme:Gene_or_gene_producttde1: trigger-arg-path: association:Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=association >prep_between theme:Gene_or_gene_productt&interceding-token ngrams: regulation .t+interceding-token ngrams: Disruption of thetXe1: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt&interceding-token ngrams: . Disruptiont0e2: ents2Label-mention-ngram: and SHARED complextMe2: trigger-arg-path: complex:Binding >nn [lemma='p190'] Gene_or_gene_producttCe1: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] themet interceding-token ngrams: of RastRe1: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='p190'] themet%interceding-token ngrams: independenttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] theme:Gene_or_gene_productt$interceding-token ngrams: DisruptiontEe2: trigger-arg-path: complex >nn [lemma='p190'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ras-gap'] themet1e1: ents2Label-mention-ngram: association betweentae1: trigger-arg-path: association:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_producttVe2: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ras-gap'] themetOe1: trigger-arg-path: association:Binding >prep_between [lemma='ras-gap'] themetSe2: trigger-arg-path: complex:Binding >nn [lemma='p190'] theme:Gene_or_gene_producttLe1: trigger-arg-path: association:Binding >prep_between Gene_or_gene_producttDe1: trigger-arg-path: association >prep_between Gene_or_gene_productt)interceding-token ngrams: . Disruption oftme1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='p190'] Gene_or_gene_producttJe1: trigger-arg-path: association >prep_between theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] themet[e1: trigger-arg-path: association:Binding >prep_between [lemma='p190'] Gene_or_gene_producttjinterceding-tokens-full-span: , independent of Ras regulation . Disruption of the phosphotyrosine mediatedtKe2: trigger-arg-path: complex >nn [lemma='p190'] theme:Gene_or_gene_productt9e2: trigger-arg-path: complex >nn [lemma='ras-gap'] themet_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >nn [lemma='ras-gap'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] Gene_or_gene_productt^e1: trigger-arg-path: association:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='p190'] theme:Gene_or_gene_productt(interceding-token ngrams: Ras regulationtVe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='p190'] themetSe1: trigger-arg-path: association >prep_between [lemma='p190'] Gene_or_gene_producttPe2: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] Gene_or_gene_productt1interceding-token ngrams: regulation . Disruptiont*interceding-token ngrams: Ras regulation .tee1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='p190'] Gene_or_gene_productt"interceding-token ngrams: mediatedt>e2: trigger-arg-path: complex:Binding >nn [lemma='p190'] themetSe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] themetEe2: trigger-arg-path: Binding >nn [lemma='p190'] Gene_or_gene_productt0e1: args2Role-mention-ngram: association betweent'interceding-token ngrams: Disruption oftpe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_producttAe2: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] themet'interceding-token ngrams: , independentte1: trigger: associationtYe1: trigger-arg-path: association >prep_between [lemma='p190'] theme:Gene_or_gene_producttRe1: trigger-arg-path: association:Binding >prep_between theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='p190'] themetOe1: trigger-arg-path: Binding >prep_between [lemma='p190'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: association between SHAREDt0interceding-token ngrams: of the phosphotyrosinetse1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt,interceding-token ngrams: independent of Rast^e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between Gene_or_gene_productt)e1: ents2Label-mention-ngram: associationt`e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] theme:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ras-gap'] Gene_or_gene_producttGe1: trigger-arg-path: association >prep_between [lemma='ras-gap'] themet\e1: trigger-arg-path: association >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: and SHAREDt=e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL mediated SHAREDtne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation vmodt4CSSPATH: ROOT >prep_on ++ ROOT >nsubj >prep_of >vmodt-e2: ents2Label-mention-ngram: SIMPLE_CHEMICALt/e2: trigger-arg-path: mediated dobj controlledt/interceding-token ngrams: cytoskeletal dynamicst>e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT complext-e2: args2Role-mention-ngram: Ras-GAP in RAT-2t&e2: ents2Label-mention-ngram: abnormalt+e2: ents2Label-mention-ngram: actin SFs andt4e2: ents2Label-mention-ngram: cells induced abnormalt~e2: trigger-arg-path: Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] Familyt&interceding-token ngrams: may functiontWe2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='adhesion'] BioProcesstte2: trigger-arg-path: decreased >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] FamilytSe1: trigger-arg-path: complex:Binding >nn [lemma='p190'] theme:Gene_or_gene_productt+interceding-token ngrams: . Over-expressiont_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn Gene_or_gene_productt%e2: args2Role-mention-ngram: in RAT-2tNe1: trigger-arg-path: complex >nn [lemma='ras-gap'] theme:Gene_or_gene_producttNe2: trigger-arg-path: decreased:Negative_activation >nsubj >prep_of >nn Familyt"e2: args2Role-mention-ngram: cellstMe2: trigger-arg-path: Negative_activation >dobj [lemma='adhesion'] controlledtAe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj controlledt'e2: ents2Label-mention-ngram: actin SFst(e2: ents2Label-mention-ngram: of Ras-GAPt?e2: trigger-arg-path: Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controllert6e1: trigger-arg-path: Binding >nn Gene_or_gene_productt"interceding-token ngrams: dynamicst6e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCTt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controllert#e2: ents2Label-mention-ngram: cellst*e1: args2Role-mention-ngram: THEME complexthe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='adhesion'] BioProcesstKe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] themet.interceding-token ngrams: together to regulatet.e2: ents2Label-mention-ngram: induced abnormaltEe1: trigger-arg-path: complex >nn [lemma='p190'] Gene_or_gene_productt*e2: args2Role-mention-ngram: and decreasedt7e2: ents2Label-mention-ngram: decreased cell substratumt"interceding-token ngrams: functiont'e2: args2Role-mention-ngram: of Ras-GAPt`e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj controlled:BioProcesst/e1: trigger-arg-path: complex:Binding >nn themetTe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='adhesion'] BioProcesste2: incoming: dobj BioProcesstbe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] Gene_or_gene_producttMe1: trigger-arg-path: complex:Binding >nn [lemma='p190'] Gene_or_gene_productte2: args2Role-mention-ngram: 2tWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] Gene_or_gene_producttinterceding-token ngrams: actint,interceding-token ngrams: Over-expression oft$interceding-token ngrams: dynamics .t&CSSPATH: ROOT >nsubj ++ ROOT >conj_andtYe2: trigger-arg-path: decreased:Negative_activation >nsubj >prep_of >nn controller:Familytje2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of >nn controller:Familyt,e2: args2Role-mention-ngram: cell substratumtse2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='adhesion'] controlled:BioProcesst%e2: args2Role-mention-ngram: terminustEe1: trigger-arg-path: Binding >nn [lemma='p190'] Gene_or_gene_productt'e2: args2Role-mention-ngram: 2 terminust&e2: ents2Label-mention-ngram: FAMILY 2t1e2: ents2Label-mention-ngram: RAT-2 cells inducedt&e2: args2Role-mention-ngram: actin SFst&e2: ents2Label-mention-ngram: in RAT-2tUe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj BioProcessthe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_producttVe1: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] themetbe2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='adhesion'] controlled:BioProcesstNe2: trigger-arg-path: decreased >dobj [lemma='adhesion'] controlled:BioProcesstxe2: trigger-arg-path: decreased >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controllertDe1: trigger-arg-path: complex:Binding >nn theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of >nn controllert5interceding-token ngrams: actin cytoskeletal dynamicst_e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of >nn Familyt$e2: args2Role-mention-ngram: SFs andt,e2: ents2Label-mention-ngram: in RAT-2 cellst.e1: args2Role-mention-ngram: and THEME complextXe2: trigger-arg-path: Negative_activation >dobj [lemma='adhesion'] controlled:BioProcesstVe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of >nn controller:Familyt+e2: args2Role-mention-ngram: in RAT-2 cellst+e2: ents2Label-mention-ngram: and decreasedt%interceding-token ngrams: to regulatet?e2: trigger-arg-path: decreased:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controller:Familyt;e2: trigger-arg-path: decreased >dobj controlled:BioProcesstHe1: trigger-arg-path: complex >nn [lemma='ras-gap'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ras-gap'] themet/e2: ents2Label-mention-ngram: FAMILY 2 terminust2e2: args2Role-mention-ngram: substratum CONTROLLEDtZe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] Gene_or_gene_productt)interceding-token ngrams: Over-expressiont5interceding-token ngrams: regulate actin cytoskeletalt?e2: trigger-arg-path: Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controller:Familyt!e2: args2Role-mention-ngram: cellt&e2: ents2Label-mention-ngram: terminust1e2: ents2Label-mention-ngram: terminus of Ras-GAPt"interceding-token ngrams: togethertRe2: trigger-arg-path: decreased:Negative_activation >nsubj >prep_of >nn controllert8e2: ents2Label-mention-ngram: cell substratum BIOPROCESSt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controller:Familyt9e1: trigger-arg-path: complex >nn [lemma='ras-gap'] themetHe1: trigger-arg-path: lemmatizedTrigger=complex >nn Gene_or_gene_producttEe2: trigger-arg-path: Negative_activation >dobj controlled:BioProcesst.e2: args2Role-mention-ngram: SFs and decreasedtCe2: trigger-arg-path: decreased >dobj [lemma='adhesion'] BioProcesstinterceding-token ngrams: mayt7e2: args2Role-mention-ngram: cell substratum CONTROLLEDte2: ents2Label-mention-ngram: 2t'e2: args2Role-mention-ngram: substratumt(e2: ents2Label-mention-ngram: 2 terminust/e2: args2Role-mention-ngram: abnormal actin SFstHe1: trigger-arg-path: Binding >nn [lemma='ras-gap'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] Familyt)e2: ents2Label-mention-ngram: RAT-2 cellst'e1: trigger-arg-path: complex >nn themet6e1: trigger-arg-path: complex >nn Gene_or_gene_productt4e2: ents2Label-mention-ngram: induced abnormal actint?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controllert9e1: trigger-arg-path: Binding >nn [lemma='ras-gap'] themet`e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ras-gap'] theme:Gene_or_gene_productt4interceding-token ngrams: dynamics . Over-expressiont'e2: args2Role-mention-ngram: Ras-GAP int-e2: args2Role-mention-ngram: induced abnormaltWe2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='adhesion'] controlledt0e2: args2Role-mention-ngram: terminus of Ras-GAPt_e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='adhesion'] controlled:BioProcesstKe1: trigger-arg-path: complex >nn [lemma='p190'] theme:Gene_or_gene_productttinterceding-tokens-full-span: may function together to regulate actin cytoskeletal dynamics . Over-expression of thetNe1: trigger-arg-path: lemmatizedTrigger=complex >nn theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: substratumt"interceding-token ngrams: regulatet(e2: args2Role-mention-ngram: RAT-2 cellst?e2: trigger-arg-path: decreased:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] Familyt3e2: args2Role-mention-ngram: cells induced abnormalt.interceding-token ngrams: . Over-expression oft*e2: args2Role-mention-ngram: cells inducedt)e2: ents2Label-mention-ngram: terminus oft,e2: ents2Label-mention-ngram: abnormal actint/e2: ents2Label-mention-ngram: SFs and decreasedt!e2: ents2Label-mention-ngram: SFst0e2: ents2Label-mention-ngram: abnormal actin SFst>e2: trigger-arg-path: decreased >nsubj >prep_of >nn controllert*e2: args2Role-mention-ngram: of Ras-GAP int%e2: ents2Label-mention-ngram: Ras-GAPt*e2: args2Role-mention-ngram: 2 terminus oft>e1: trigger-arg-path: complex:Binding >nn [lemma='p190'] themet+e2: args2Role-mention-ngram: abnormal actinthe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='adhesion'] controlledt0e2: args2Role-mention-ngram: RAT-2 cells inducedtDe2: trigger-arg-path: decreased:Negative_activation >dobj BioProcesstnn theme:Gene_or_gene_productt.interceding-token ngrams: function together totHe2: trigger-arg-path: Negative_activation >nsubj >prep_of >nn controllertAe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj BioProcesstAe1: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] themet(e2: ents2Label-mention-ngram: BIOPROCESSt+interceding-token ngrams: to regulate actint0e2: trigger-arg-path: decreased >dobj controlledt1interceding-token ngrams: cytoskeletal dynamics .t?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controller:FamilytMe2: trigger-arg-path: Negative_activation >dobj [lemma='adhesion'] BioProcesst9e1: trigger-arg-path: lemmatizedTrigger=complex >nn themet:e2: trigger-arg-path: decreased >nsubj >prep_of >nn Familyt"e2: args2Role-mention-ngram: actintTe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='adhesion'] controlledt6e1: trigger-arg-path: Binding >nn [lemma='p190'] themet(e2: ents2Label-mention-ngram: Ras-GAP intDe2: trigger-arg-path: Negative_activation >nsubj >prep_of >nn Familyt+e2: args2Role-mention-ngram: decreased cellt+e2: ents2Label-mention-ngram: cells inducedt/e2: args2Role-mention-ngram: and decreased cellt?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] FamilytLe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj controlled:BioProcesst,e2: ents2Label-mention-ngram: decreased cellte2: trigger: decreasedtOe2: trigger-arg-path: decreased:Negative_activation >dobj controlled:BioProcesst:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT complext,interceding-token ngrams: actin cytoskeletalt#e2: ents2Label-mention-ngram: actintKe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and GENE_OR_GENE_PRODUCTtUe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj controlledtPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='p190'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: RAT-2t2e2: args2Role-mention-ngram: CONTROLLER 2 terminust+e2: ents2Label-mention-ngram: of Ras-GAP int/interceding-token ngrams: may function togethert'e1: trigger-arg-path: Binding >nn themet+e2: ents2Label-mention-ngram: 2 terminus oftAe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn themetce2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of >nn controllert&interceding-token ngrams: cytoskeletaltnn theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: actin SFs andt6e2: args2Role-mention-ngram: decreased cell substratumt(e2: args2Role-mention-ngram: terminus oftCe2: trigger-arg-path: decreased >dobj [lemma='adhesion'] controlledt0e2: ents2Label-mention-ngram: and decreased cellt'e2: ents2Label-mention-ngram: decreasedt0interceding-token ngrams: Over-expression of thet&e2: args2Role-mention-ngram: decreasedt3e2: ents2Label-mention-ngram: substratum BIOPROCESStPe1: trigger-arg-path: complex:Binding >nn [lemma='ras-gap'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: cellt.e2: ents2Label-mention-ngram: Ras-GAP in RAT-2t#e2: ents2Label-mention-ngram: RAT-2t%e2: args2Role-mention-ngram: abnormalt)e2: args2Role-mention-ngram: CONTROLLER 2tOe2: trigger-arg-path: Negative_activation >nsubj >prep_of >nn controller:Familyt-e2: ents2Label-mention-ngram: cell substratumte2: trigger-arg-path: decreased >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controller:FamilytVe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p190'] theme:Gene_or_gene_productt:e2: trigger-arg-path: Negative_activation >dobj BioProcesst?e2: trigger-arg-path: decreased:Negative_activation >nsubj [lemma='over-expression'] >prep_of [lemma='terminus'] >nn [lemma='NH'] controllertHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] themet]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p190'] theme:Gene_or_gene_productt6e1: trigger-arg-path: complex >nn [lemma='p190'] themet(interceding-token ngrams: regulate actint%e2: ents2Label-mention-ngram: SFs andt%interceding-token ngrams: together totNe1: trigger-arg-path: Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_productt e2: args2Role-mention-ngram: SFstKe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of >nn Familyt3e2: args2Role-mention-ngram: induced abnormal actint+interceding-token ngrams: function togethert$e2: args2Role-mention-ngram: Ras-GAPtEe2: trigger-arg-path: decreased >nsubj >prep_of >nn controller:Familyte1: trigger: complext.interceding-token ngrams: turnover observed intWe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ras-gap'] themetre2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ras-gap'] Gene_or_gene_producttinterceding-token ngrams: SFt$interceding-token ngrams: GAP mutantt(interceding-token ngrams: peptides leadst interceding-token ngrams: and FAtinterceding-token ngrams: to atLe1: trigger-arg-path: interaction >nn [lemma='ras-gap'] Gene_or_gene_productt)interceding-token ngrams: mutant cells istze2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ras-gap'] Gene_or_gene_producttOe1: trigger-arg-path: interaction >nn [lemma='p190'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding nn [lemma='p190'] themet interceding-token ngrams: SF andtfe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ras-gap'] Gene_or_gene_producttee2: trigger-arg-path: complex:Binding nn [lemma='p190'] Gene_or_gene_productt&interceding-token ngrams: is dependentt%interceding-token ngrams: , this losstRe2: trigger-arg-path: lemmatizedTrigger=complex nn theme:Gene_or_gene_productt'interceding-token ngrams: failure of SFt+e1: trigger-arg-path: interaction >nn themetinterceding-token ngrams: of SFtWe1: trigger-arg-path: interaction:Binding >nn [lemma='p190'] theme:Gene_or_gene_productt interceding-token ngrams: Thus ,tNe2: trigger-arg-path: complex nn [lemma='p190'] themet#interceding-token ngrams: a failuret:e1: trigger-arg-path: interaction >nn [lemma='p190'] themetue2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p190'] theme:Gene_or_gene_productt%interceding-token ngrams: of turnovert+interceding-token ngrams: and FA remodelingtYe2: trigger-arg-path: complex:Binding nn [lemma='ras-gap'] themetTe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ras-gap'] Gene_or_gene_productt!interceding-token ngrams: failuret.e1: args2Role-mention-ngram: THEME interactiontae1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='p190'] theme:Gene_or_gene_productt(interceding-token ngrams: dependent upontEe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn themet4e1: ents2Label-mention-ngram: and SHARED interactiont"interceding-token ngrams: specifictde1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ras-gap'] theme:Gene_or_gene_productt%interceding-token ngrams: observed int*interceding-token ngrams: loss of turnovertZe1: trigger-arg-path: interaction:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_producttfe2: trigger-arg-path: complex nn [lemma='ras-gap'] theme:Gene_or_gene_productt@e2: trigger-arg-path: complex nn theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='p190'] Gene_or_gene_productt$interceding-token ngrams: in Ras GAPt=e2: trigger-arg-path: lemmatizedTrigger=complex nn themetLe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='p190'] themetTe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn Gene_or_gene_productt3e2: trigger-arg-path: complex:Binding nn themet#interceding-token ngrams: SF and FAt"interceding-token ngrams: cells istHe2: trigger-arg-path: complex:Binding nn theme:Gene_or_gene_producttVe2: trigger-arg-path: complex:Binding nn [lemma='p190'] themet"interceding-token ngrams: leads tot"interceding-token ngrams: . Thus ,t+interceding-token ngrams: peptides leads tot&interceding-token ngrams: to a failuret[e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='p190'] Gene_or_gene_producttfe2: trigger-arg-path: Binding nn [lemma='ras-gap'] theme:Gene_or_gene_productt interceding-token ngrams: in RastZe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn theme:Gene_or_gene_productt+interceding-token ngrams: remodeling . Thust2e1: args2Role-mention-ngram: and THEME interactiont*interceding-token ngrams: GAP mutant cellstBe1: trigger-arg-path: interaction:Binding >nn Gene_or_gene_productt1interceding-token ngrams: specific peptides leadstne2: trigger-arg-path: complex:Binding nn [lemma='ras-gap'] theme:Gene_or_gene_producttHe1: trigger-arg-path: interaction:Binding >nn theme:Gene_or_gene_productt;CSSPATH: ROOT >ccomp >nsubj >prep_of ++ ROOT >prep_upon >nntLe2: trigger-arg-path: lemmatizedTrigger=complex nn Gene_or_gene_productt#interceding-token ngrams: this losstxe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ras-gap'] theme:Gene_or_gene_productt!interceding-token ngrams: phosphotoe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p190'] Gene_or_gene_productt3e1: trigger-arg-path: interaction:Binding >nn themetOe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ras-gap'] themet-interceding-token ngrams: by phospho specifictinterceding-token ngrams: FAtZe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=interaction >nn theme:Gene_or_gene_producttQe2: trigger-arg-path: Binding nn [lemma='ras-gap'] themet=e1: trigger-arg-path: interaction >nn [lemma='ras-gap'] themet=e1: trigger-arg-path: lemmatizedTrigger=interaction >nn themet,interceding-token ngrams: cells is dependentt+e2: trigger-arg-path: complex nn themetEe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn themet+e2: trigger-arg-path: Binding nn themetinterceding-token ngrams: Thust)interceding-token ngrams: FA remodeling .t"interceding-token ngrams: peptidest interceding-token ngrams: , thist)interceding-token ngrams: observed in RastTe1: trigger-arg-path: interaction:Binding >nn [lemma='ras-gap'] Gene_or_gene_productt&interceding-token ngrams: remodeling .tke2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ras-gap'] themet@e1: trigger-arg-path: interaction >nn theme:Gene_or_gene_productt:e1: trigger-arg-path: interaction >nn Gene_or_gene_productt!interceding-token ngrams: loss oftinterceding-token ngrams: GAPtTe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='p190'] themet`e2: trigger-arg-path: complex nn [lemma='ras-gap'] Gene_or_gene_productt$interceding-token ngrams: failure oftinterceding-token ngrams: leadst0e1: ents2Label-mention-ngram: SHARED interactiont$interceding-token ngrams: remodelingt+interceding-token ngrams: is dependent upont&interceding-token ngrams: a failure oft]e2: trigger-arg-path: complex nn [lemma='p190'] Gene_or_gene_productt"interceding-token ngrams: observedt`e2: trigger-arg-path: Binding nn [lemma='ras-gap'] Gene_or_gene_productt(interceding-token ngrams: Ras GAP mutanttinterceding-token ngrams: losstce2: trigger-arg-path: Binding nn [lemma='p190'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='p190'] theme:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p190'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ras-gap'] themet]e2: trigger-arg-path: Binding nn [lemma='p190'] Gene_or_gene_productt&interceding-token ngrams: this loss oft!interceding-token ngrams: Ras GAPt$interceding-token ngrams: leads to at:e2: trigger-arg-path: Binding nn Gene_or_gene_productt#interceding-token ngrams: of SF andt?interceding-tokens-full-span: by phospho specific peptides leads to a failure of SF and FA remodeling . Thus , this loss of turnover observed in Ras GAP mutant cells is dependent upont`e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p190'] themet+interceding-token ngrams: turnover observedt3interceding-token ngrams: phospho specific peptidest interceding-token ngrams: . Thust.interceding-token ngrams: of turnover observedtBe2: trigger-arg-path: complex:Binding nn Gene_or_gene_producttIe1: trigger-arg-path: interaction >nn [lemma='p190'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interaction >nn Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ras-gap'] theme:Gene_or_gene_productt*interceding-token ngrams: phospho specifictQe1: trigger-arg-path: interaction:Binding >nn [lemma='p190'] Gene_or_gene_productt:e2: trigger-arg-path: complex nn Gene_or_gene_productt"interceding-token ngrams: turnovert?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ras-gap'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interaction >nn [lemma='ras-gap'] theme:Gene_or_gene_productt%interceding-token ngrams: Thus , thist+interceding-token ngrams: specific peptidestQe2: trigger-arg-path: complex nn [lemma='ras-gap'] themetBe1: trigger-arg-path: interaction:Binding >nn [lemma='p190'] themetce2: trigger-arg-path: complex nn [lemma='p190'] theme:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p190'] theme:Gene_or_gene_producttke2: trigger-arg-path: complex:Binding nn [lemma='p190'] theme:Gene_or_gene_productt$interceding-token ngrams: by phosphot&interceding-token ngrams: mutant cellsthe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p190'] themetEe1: trigger-arg-path: interaction:Binding >nn [lemma='ras-gap'] themethe2: trigger-arg-path: complex:Binding nn [lemma='ras-gap'] Gene_or_gene_productt@e2: trigger-arg-path: Binding nn theme:Gene_or_gene_productt'interceding-token ngrams: FA remodelingt%interceding-token ngrams: the correctt%interceding-token ngrams: function oft%interceding-token ngrams: SFs and FAstve2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt,interceding-token ngrams: pTyr dependent andt%interceding-token ngrams: is requiredt*interceding-token ngrams: correct temporalt#interceding-token ngrams: that thistinterceding-token ngrams: SFst&interceding-token ngrams: of actin SFst"interceding-token ngrams: temporaltinterceding-token ngrams: pTyrt\e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between theme:Gene_or_gene_productt(interceding-token ngrams: pTyr dependentt)e2: args2Role-mention-ngram: interactionst)interceding-token ngrams: pTyr mediated .t0e1: ents2Label-mention-ngram: and SHARED complextpe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_producttee2: trigger-arg-path: interactions:Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt.interceding-token ngrams: correct temporal Rhot+interceding-token ngrams: function of actint^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p190'] themet'interceding-token ngrams: dependent andtVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between Gene_or_gene_productt7e2: args2Role-mention-ngram: interactions between THEMEt-interceding-token ngrams: dependent and minort+interceding-token ngrams: mediated . reporttEe2: trigger-arg-path: interactions >prep_between [lemma='p190'] themetinterceding-token ngrams: majort&interceding-token ngrams: Rho functiontinterceding-token ngrams: FAst*interceding-token ngrams: pTyr independentt]e2: trigger-arg-path: interactions >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt/interceding-token ngrams: temporal Rho functiontGe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between themetTe2: trigger-arg-path: interactions >prep_between [lemma='p190'] Gene_or_gene_productt\e2: trigger-arg-path: interactions:Binding >prep_between [lemma='p190'] Gene_or_gene_producttXe2: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interactions:Binding >prep_between Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p190'] Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_between Gene_or_gene_productt>e2: trigger-arg-path: interactions:Binding >prep_between themet(interceding-token ngrams: . report majortme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p190'] Gene_or_gene_productt"interceding-token ngrams: and thattinterceding-token ngrams: Rhot'interceding-token ngrams: and that thist#interceding-token ngrams: actin SFst&interceding-token ngrams: temporal RhotSe2: trigger-arg-path: interactions:Binding >prep_between theme:Gene_or_gene_productt'interceding-token ngrams: actin SFs andtbe2: trigger-arg-path: interactions:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt(interceding-token ngrams: and minor pTyrt&interceding-token ngrams: report majortde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between theme:Gene_or_gene_productt$interceding-token ngrams: major pTyrt?interceding-tokens-full-span: is required for the correct temporal Rho function of actin SFs and FAs and that this interaction is pTyr mediated . report major pTyr dependent and minor pTyr independenttUe2: trigger-arg-path: Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt)interceding-token ngrams: Rho function oft_e2: trigger-arg-path: interactions:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_productt)interceding-token ngrams: is required fort&interceding-token ngrams: required fortne2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt!interceding-token ngrams: and FAst!interceding-token ngrams: is pTyrt(interceding-token ngrams: interaction istke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p190'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: interactions betweentHe2: trigger-arg-path: interactions >prep_between [lemma='ras-gap'] themet$interceding-token ngrams: minor pTyrt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between Gene_or_gene_producttZe2: trigger-arg-path: interactions >prep_between [lemma='p190'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >prep_between theme:Gene_or_gene_productt*interceding-token ngrams: required for thetOe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between themet!interceding-token ngrams: FAs andt+interceding-token ngrams: report major pTyrtPe2: trigger-arg-path: interactions:Binding >prep_between [lemma='ras-gap'] themet!interceding-token ngrams: SFs andt&interceding-token ngrams: FAs and thattinterceding-token ngrams: minorthe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras-gap'] Gene_or_gene_producttCe2: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] themet!interceding-token ngrams: for thetEe2: trigger-arg-path: interactions >prep_between Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p190'] themet interceding-token ngrams: reportt*interceding-token ngrams: this interactiont%interceding-token ngrams: and FAs andt$interceding-token ngrams: mediated .t.interceding-token ngrams: major pTyr dependentt-interceding-token ngrams: interaction is pTyrt*interceding-token ngrams: is pTyr mediatedt"interceding-token ngrams: of actinte2: trigger: interactionstMe2: trigger-arg-path: interactions:Binding >prep_between [lemma='p190'] themet/interceding-token ngrams: that this interactiont!interceding-token ngrams: correcttRe2: trigger-arg-path: Binding >prep_between [lemma='ras-gap'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: interactions betweent5CSSPATH: ROOT >ccomp >nsubjpass >prep_of ++ ROOT >dept'interceding-token ngrams: pTyr mediatedt6e2: trigger-arg-path: interactions >prep_between themetYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras-gap'] themetWe2: trigger-arg-path: interactions >prep_between [lemma='ras-gap'] Gene_or_gene_producttKe2: trigger-arg-path: interactions >prep_between theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED complext@e2: trigger-arg-path: Binding >prep_between [lemma='p190'] themet-interceding-token ngrams: this interaction ist"interceding-token ngrams: requiredt.interceding-token ngrams: the correct temporalt)interceding-token ngrams: for the correctt9e2: ents2Label-mention-ngram: interactions between SHAREDt1e2: trigger-arg-path: Binding >prep_between themetae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] themet"interceding-token ngrams: . reporttOe2: trigger-arg-path: Binding >prep_between [lemma='p190'] Gene_or_gene_productt0interceding-token ngrams: minor pTyr independentt#interceding-token ngrams: and minort-interceding-token ngrams: a mechanism wherebyt?e2: trigger-arg-path: lemmatizedTrigger=complex prep_between [lemma='ras-gap'] theme:Gene_or_gene_producttVe2: trigger-arg-path: complex:Binding prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt_e1: trigger-arg-path: interactions:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_productt#interceding-token ngrams: visualizetTe2: trigger-arg-path: Binding prep_between Gene_or_gene_producttinterceding-token ngrams: . Itt>e1: trigger-arg-path: interactions:Binding >prep_between themet$interceding-token ngrams: attractivetMe1: trigger-arg-path: interactions:Binding >prep_between Gene_or_gene_productt(interceding-token ngrams: an active pTyrtGe2: trigger-arg-path: complex:Binding prep_between [lemma='p190'] theme:Gene_or_gene_productt+interceding-token ngrams: whereby an activetne2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_between [lemma='p190'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] theme:Gene_or_gene_producttTe2: trigger-arg-path: complex prep_between [lemma='p190'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_between [lemma='ras-gap'] Gene_or_gene_producttbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p190'] themete1: trigger: interactionstse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p190'] theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex prep_between [lemma='ras-gap'] theme:Gene_or_gene_productt#interceding-token ngrams: an activet interceding-token ngrams: activet?e2: trigger-arg-path: Binding prep_between [lemma='p190'] themet-e2: trigger-arg-path: complex prep_between [lemma='p190'] themet#interceding-token ngrams: mechanismtMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='p190'] themetYe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras-gap'] themetPe1: trigger-arg-path: interactions:Binding >prep_between [lemma='ras-gap'] themetprep_between [lemma='p190'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_between theme:Gene_or_gene_productt(interceding-token ngrams: to visualize at!interceding-token ngrams: . It istee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p190'] Gene_or_gene_productt5e2: trigger-arg-path: complex:Binding prep_between themet*interceding-token ngrams: It is attractivet$interceding-token ngrams: whereby antNe2: trigger-arg-path: complex dep ++ ROOT >xcomp >advcl >nsubjt!interceding-token ngrams: wherebythe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras-gap'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_between [lemma='ras-gap'] themet%interceding-token ngrams: a mechanismtjinterceding-tokens-full-span: . It is attractive to visualize a mechanism whereby an active pTyr dependenttae1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras-gap'] themet+interceding-token ngrams: mechanism wherebytNe2: trigger-arg-path: Binding prep_between theme:Gene_or_gene_productt%interceding-token ngrams: active pTyrtinterceding-token ngrams: It istZe1: trigger-arg-path: interactions >prep_between [lemma='p190'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex:Binding agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controllertPe1: trigger-arg-path: farnesylation >prep_by [lemma='hr12'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controller:Gene_or_gene_productt$interceding-token ngrams: of solublet-e2: ents2Label-mention-ngram: the kinetics oft?e2: trigger-arg-path: induced >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controller:Gene_or_gene_productt!interceding-token ngrams: shown )tZe1: trigger-arg-path: farnesylation:Positive_regulation >prep_by [lemma='hr12'] controllert.e2: ents2Label-mention-ngram: and the kineticstne2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='ra'] controlled:FamilytLe1: trigger-arg-path: farnesylation >prep_by controller:Gene_or_gene_producttHe2: trigger-arg-path: Positive_activation >agent >prep_of >nn controllertJe2: trigger-arg-path: lemmatizedTrigger=induce nn controlled:Familyt"interceding-token ngrams: the doset&e2: ents2Label-mention-ngram: kineticst?e2: trigger-arg-path: induced:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: HR12 treatment andt1interceding-token ngrams: dependent inhibition oft interceding-token ngrams: a dosetce2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='ra'] Familyt)interceding-token ngrams: the kinetics oft,e2: args2Role-mention-ngram: induced by HR12t,interceding-token ngrams: dependent decreaset?e2: trigger-arg-path: Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controller:Gene_or_gene_productt"interceding-token ngrams: data nott?e2: trigger-arg-path: induced:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controllertFe2: trigger-arg-path: induced >agent >prep_of >nn Gene_or_gene_productt&interceding-token ngrams: activation ,t/e2: args2Role-mention-ngram: HR12 treatment andt-interceding-token ngrams: which parallels thet.e2: trigger-arg-path: induced nn FamilytSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn Familyt#interceding-token ngrams: shown ) .t'e2: ents2Label-mention-ngram: treatmentt^e2: trigger-arg-path: Positive_activation nn [lemma='ra'] Familyt,e2: args2Role-mention-ngram: the kinetics oftqe2: trigger-arg-path: induced:Positive_activation nn [lemma='ra'] controlled:Familyt'interceding-token ngrams: morphologicaltAe1: trigger-arg-path: farnesylation >prep_by Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED accumulationt4e2: args2Role-mention-ngram: CONTROLLED accumulationtFe1: trigger-arg-path: farnesylation >prep_by [lemma='hr12'] controllert-e2: args2Role-mention-ngram: and the kineticst+interceding-token ngrams: the morphologicalt$e2: args2Role-mention-ngram: by HR12t.e1: ents2Label-mention-ngram: farnesylation byt,e2: ents2Label-mention-ngram: HR12 treatmentt!interceding-token ngrams: and thet#interceding-token ngrams: in a doset+e2: args2Role-mention-ngram: HR12 treatmentt"interceding-token ngrams: decreaset2e2: trigger-arg-path: induced nn controlledtve1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by [lemma='hr12'] Gene_or_gene_productt1e2: args2Role-mention-ngram: accumulation inducedt?e2: trigger-arg-path: Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] Gene_or_gene_producttinterceding-token ngrams: ) .t4e2: args2Role-mention-ngram: accumulation induced bytbe2: trigger-arg-path: Positive_activation nn [lemma='ra'] controlledt3e2: args2Role-mention-ngram: kinetics of CONTROLLERt.e2: args2Role-mention-ngram: by HR12 treatmentt/interceding-token ngrams: morphological changest interceding-token ngrams: in Erkt&interceding-token ngrams: the kineticst interceding-token ngrams: ( datat"interceding-token ngrams: Second ,tinterceding-token ngrams: Erkt?e2: trigger-arg-path: lemmatizedTrigger=induce nn FamilytKe1: trigger-arg-path: farnesylation:Positive_regulation >prep_by controllert/interceding-token ngrams: dependent decrease int*interceding-token ngrams: Erk activation ,tinterceding-token ngrams: whicht&e2: args2Role-mention-ngram: treatmentt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='ra'] controlled:Familytinterceding-token ngrams: datat+interceding-token ngrams: inhibition of Rast]e2: trigger-arg-path: induced nn [lemma='ra'] controlled:Familyt&interceding-token ngrams: results in at2e2: ents2Label-mention-ngram: accumulation inducedt3interceding-token ngrams: dose dependent inhibitiont,interceding-token ngrams: activation , whicht,interceding-token ngrams: parallels the doset^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn controlled:Familytbe1: trigger-arg-path: lemmatizedTrigger=farnesylation >prep_by [lemma='hr12'] Gene_or_gene_productt(interceding-token ngrams: data not showntWe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] Gene_or_gene_productt#interceding-token ngrams: changes (t*e2: ents2Label-mention-ngram: the kineticst)interceding-token ngrams: decrease in Erktge1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=farnesylation >prep_by controller:Gene_or_gene_productt.interceding-token ngrams: dependent inhibitiontagent >prep_of >nn controllertBe2: trigger-arg-path: induced:Positive_activation nn Familyt$interceding-token ngrams: ( data nott*e2: ents2Label-mention-ngram: accumulationt(interceding-token ngrams: changes ( datat interceding-token ngrams: Secondtve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent >prep_of >nn controller:Gene_or_gene_producttinterceding-token ngrams: doset?e2: trigger-arg-path: Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controllertZe2: trigger-arg-path: induced:Positive_activation >agent >prep_of >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controllert.e2: args2Role-mention-ngram: treatment and thetEe2: trigger-arg-path: Positive_activation nn controlled:Familyt*interceding-token ngrams: a dose dependenttXe1: trigger-arg-path: lemmatizedTrigger=farnesylation >prep_by [lemma='hr12'] controllert/e2: ents2Label-mention-ngram: by HR12 treatmentte1: trigger: farnesylationt1interceding-token ngrams: morphological changes (tie2: trigger-arg-path: Positive_activation nn [lemma='ra'] controlled:Familyt#interceding-token ngrams: parallelst#interceding-token ngrams: not showntMe2: trigger-arg-path: induced:Positive_activation nn controlled:Familyt5e2: ents2Label-mention-ngram: accumulation induced byt,interceding-token ngrams: the dose dependentt2e1: ents2Label-mention-ngram: farnesylation by thetee2: trigger-arg-path: induced:Positive_activation >agent >prep_of >nn controller:Gene_or_gene_producttprep_by [lemma='hr12'] controller:Gene_or_gene_productt[e1: trigger-arg-path: farnesylation >prep_by [lemma='hr12'] controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by [lemma='hr12'] controllert:e2: trigger-arg-path: Positive_activation nn FamilytMe2: trigger-arg-path: lemmatizedTrigger=induce >agent >prep_of >nn controllert!e2: args2Role-mention-ngram: HR12t>e2: ents2Label-mention-ngram: kinetics of GENE_OR_GENE_PRODUCTt+interceding-token ngrams: , which parallelstae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent >prep_of >nn controllert{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='ra'] controlledt9e1: ents2Label-mention-ngram: by the GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by [lemma='hr12'] controller:Gene_or_gene_producttde1: trigger-arg-path: farnesylation:Positive_regulation >prep_by [lemma='hr12'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='ra'] controlledtVe1: trigger-arg-path: Positive_regulation >prep_by [lemma='hr12'] Gene_or_gene_productt~e2: trigger-arg-path: induced >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] Gene_or_gene_productt/interceding-token ngrams: farnesylation and thet)e2: ents2Label-mention-ngram: kinetics oft>e2: trigger-arg-path: Positive_activation nn controlledt%interceding-token ngrams: kinetics oftQe2: trigger-arg-path: induced >agent >prep_of >nn controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: treatment and thet)e2: args2Role-mention-ngram: the kineticst&interceding-token ngrams: Second , thetoe1: trigger-arg-path: farnesylation:Positive_regulation >prep_by [lemma='hr12'] controller:Gene_or_gene_productt!interceding-token ngrams: , whicht'interceding-token ngrams: farnesylationt?e2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: and thet)e2: args2Role-mention-ngram: accumulationt`e1: trigger-arg-path: farnesylation:Positive_regulation >prep_by controller:Gene_or_gene_productt$interceding-token ngrams: activationt"interceding-token ngrams: . Secondt9e2: ents2Label-mention-ngram: SHARED accumulation inducedt/interceding-token ngrams: and the morphologicaltUe1: trigger-arg-path: farnesylation:Positive_regulation >prep_by Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='ra'] Familyt$interceding-token ngrams: results int"interceding-token ngrams: kineticst%interceding-token ngrams: not shown )t/interceding-token ngrams: Ras farnesylation andtae1: trigger-arg-path: Positive_regulation >prep_by [lemma='hr12'] controller:Gene_or_gene_productt+interceding-token ngrams: Ras farnesylationt+e1: ents2Label-mention-ngram: farnesylationt$interceding-token ngrams: . Second ,t!interceding-token ngrams: solublet'interceding-token ngrams: parallels thetWe2: trigger-arg-path: lemmatizedTrigger=induce >agent >prep_of >nn Gene_or_gene_productt'e2: args2Role-mention-ngram: induced byt(interceding-token ngrams: , the kineticst*e2: args2Role-mention-ngram: treatment andtVe2: trigger-arg-path: induced nn [lemma='ra'] controlledt7e1: trigger-arg-path: farnesylation >prep_by controllert9e2: trigger-arg-path: induced nn controlled:Familyt)interceding-token ngrams: which parallelstFe2: trigger-arg-path: induced:Positive_activation nn controlledt$interceding-token ngrams: inhibitiont%interceding-token ngrams: decrease intCe2: trigger-arg-path: lemmatizedTrigger=induce nn controlledtre1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by controller:Gene_or_gene_productt(interceding-token ngrams: dose dependenttje2: trigger-arg-path: induced:Positive_activation nn [lemma='ra'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: HR12tRe2: trigger-arg-path: Positive_activation >agent >prep_of >nn Gene_or_gene_productt1interceding-token ngrams: dose dependent decreaset'interceding-token ngrams: inhibition oft]e2: trigger-arg-path: Positive_activation >agent >prep_of >nn controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: kineticst%e2: ents2Label-mention-ngram: by HR12t2e1: ents2Label-mention-ngram: SHARED farnesylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] controllert$e2: args2Role-mention-ngram: and thet(e2: args2Role-mention-ngram: kinetics oft$interceding-token ngrams: ) . Secondt+interceding-token ngrams: in Erk activationtSe1: trigger-arg-path: lemmatizedTrigger=farnesylation >prep_by Gene_or_gene_producttfe2: trigger-arg-path: induced:Positive_activation nn [lemma='ra'] FamilytBCSSPATH: ROOT >ccomp >nsubj >prep_of ++ ROOT >nsubj >prep_of >vmodtLe1: trigger-arg-path: Positive_regulation >prep_by [lemma='hr12'] controllert(e2: ents2Label-mention-ngram: induced bytPe2: trigger-arg-path: induced:Positive_activation >agent >prep_of >nn controllert+e2: ents2Label-mention-ngram: treatment andt-interceding-token ngrams: kinetics of solubletke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent >prep_of >nn Gene_or_gene_producttRe2: trigger-arg-path: induced nn [lemma='ra'] FamilytIe1: trigger-arg-path: lemmatizedTrigger=farnesylation >prep_by controllertbe2: trigger-arg-path: lemmatizedTrigger=induce >agent >prep_of >nn controller:Gene_or_gene_productt!interceding-token ngrams: changest3interceding-token ngrams: the morphological changest]e1: trigger-arg-path: lemmatizedTrigger=farnesylation:Positive_regulation >prep_by controllert+interceding-token ngrams: farnesylation andt?interceding-tokens-full-span: results in a dose dependent decrease in Erk activation , which parallels the dose dependent inhibition of Ras farnesylation and the morphological changes ( data not shown ) . Second , the kinetics of solublet?e2: trigger-arg-path: induced:Positive_activation >agent [lemma='kinetics'] >prep_of [lemma='inactivation'] >nn [lemma='mek'] Gene_or_gene_productt!interceding-token ngrams: resultst.interceding-token ngrams: of Ras farnesylationtinterceding-token ngrams: shownt-e2: ents2Label-mention-ngram: induced by HR12t]e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pkcalpha'] controllertNinterceding-tokens-full-span: independently of Ras . Indeed , it is shown thattSe1: trigger-arg-path: Positive_activation >nsubj [lemma='pkc'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] controlled:Gene_or_gene_productt/e1: trigger-arg-path: activate >dobj controlledt%interceding-token ngrams: it is shownt-e1: ents2Label-mention-ngram: activate SHAREDtPe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='pkc'] controllertRe1: trigger-arg-path: Positive_activation >dobj [lemma='raf'] Gene_or_gene_productt interceding-token ngrams: Indeedt"interceding-token ngrams: Indeed ,tpe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: is shownt,e2: ents2Label-mention-ngram: phosphorylatest`e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='pkc'] controllertLe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj Gene_or_gene_productt"interceding-token ngrams: of Ras .t$e2: ents2Label-mention-ngram: Ser499tGe1: trigger-arg-path: activate >dobj [lemma='raf'] Gene_or_gene_productt'interceding-token ngrams: independentlyt_e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj Gene_or_gene_productt+e1: args2Role-mention-ngram: CONTROLLER cantce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] controlledtUe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlledtKe1: trigger-arg-path: lemmatizedTrigger=activate >dobj Gene_or_gene_producttOe1: trigger-arg-path: Positive_activation >dobj controlled:Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylates SHARED attMe1: trigger-arg-path: activate:Positive_activation >dobj Gene_or_gene_producttfe1: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_producttSe2: trigger-arg-path: phosphorylates >nsubj [lemma='pkcalpha'] Gene_or_gene_productt^e2: trigger-arg-path: phosphorylates >nsubj [lemma='pkcalpha'] controller:Gene_or_gene_producttDe1: trigger-arg-path: activate:Positive_activation >nsubj controllert^e1: trigger-arg-path: Positive_activation >nsubj [lemma='pkc'] controller:Gene_or_gene_productt"interceding-token ngrams: . IndeedtIe2: trigger-arg-path: phosphorylates >nsubj [lemma='pkcalpha'] controllertCSSPATH: ROOT  ++ ROOT >ccompt e2: ents2Label-mention-ngram: att>e1: trigger-arg-path: activate >nsubj [lemma='pkc'] controllert[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj controllert=e1-label: Positive_activation + e2-label: Positive_regulationt3e2: ents2Label-mention-ngram: phosphorylates SHAREDt)e1: args2Role-mention-ngram: can activatet4e1: args2Role-mention-ngram: CONTROLLER can activatetje1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlled:Gene_or_gene_producttXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pkcalpha'] Gene_or_gene_producttre2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pkcalpha'] controller:Gene_or_gene_productt*interceding-token ngrams: independently oftJe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj controllertOe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] controlledt'e2: ents2Label-mention-ngram: SHARED attTe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj Gene_or_gene_producttDe1: trigger-arg-path: activate >dobj controlled:Gene_or_gene_productte2: trigger: phosphorylatest=e1: trigger-arg-path: activate >dobj [lemma='raf'] controlledtinterceding-token ngrams: , itt9e1: trigger-arg-path: activate >dobj Gene_or_gene_producttinterceding-token ngrams: it istYe1: trigger-arg-path: activate:Positive_activation >nsubj controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: activatet$interceding-token ngrams: . Indeed ,t0e1: trigger-arg-path: activate >nsubj controllertge1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='pkc'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='pkc'] Gene_or_gene_producttNe1: trigger-arg-path: activate:Positive_activation >nsubj Gene_or_gene_productt0e1: args2Role-mention-ngram: activate CONTROLLEDtinterceding-token ngrams: Ras .t&e1: ents2Label-mention-ngram: activatet&interceding-token ngrams: Ras . IndeedtKe2: trigger-arg-path: phosphorylates >nsubj controller:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=activate >dobj controlledt_e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj controller:Gene_or_gene_producttEe1: trigger-arg-path: activate >nsubj controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pkcalpha'] controllertinterceding-token ngrams: ittWe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: can activate CONTROLLEDtce2: trigger-arg-path: Positive_regulation >nsubj [lemma='pkcalpha'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkcalpha'] controller:Gene_or_gene_producttRe1: trigger-arg-path: activate >dobj [lemma='raf'] controlled:Gene_or_gene_productt6e2: trigger-arg-path: phosphorylates >nsubj controllertge2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pkcalpha'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylatest.e2: ents2Label-mention-ngram: SHARED at Ser499t*e1: ents2Label-mention-ngram: can activatetxe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkcalpha'] Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj controllertHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates SHAREDt[e1: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf'] Gene_or_gene_producttRe1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='pkc'] controllertYe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controllert%interceding-token ngrams: Indeed , ittoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkcalpha'] controller:Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can activatet'e2: ents2Label-mention-ngram: at Ser499tne2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkcalpha'] controllert'interceding-token ngrams: is shown thattye1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='pkc'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='pkc'] controller:Gene_or_gene_producttSe1: trigger-arg-path: activate >nsubj [lemma='pkc'] controller:Gene_or_gene_producttQe1: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf'] controlledte1: trigger: activatet!interceding-token ngrams: , it istde2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkcalpha'] Gene_or_gene_producttXe1: trigger-arg-path: activate:Positive_activation >dobj controlled:Gene_or_gene_productt]e1: trigger-arg-path: Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkcalpha'] controllert@e2: trigger-arg-path: phosphorylates >nsubj Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=activate >dobj controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj controller:Gene_or_gene_productt:e1: trigger-arg-path: activate >nsubj Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER CONTROLLEDt1e1: ents2Label-mention-ngram: can activate SHAREDtQe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj Gene_or_gene_producttHe1: trigger-arg-path: Positive_activation >dobj [lemma='raf'] controlledtGe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj controllert\e1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='pkc'] Gene_or_gene_producttCe1: trigger-arg-path: activate:Positive_activation >dobj controlledtHe1: trigger-arg-path: activate >nsubj [lemma='pkc'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='pkc'] Gene_or_gene_productt.interceding-token ngrams: independently of RastIe1: trigger-arg-path: Positive_activation >nsubj [lemma='pkc'] controllertDe1: trigger-arg-path: Positive_activation >dobj Gene_or_gene_productt$interceding-token ngrams: shown thatt8e2: ents2Label-mention-ngram: interaction between FAMILYt(interceding-token ngrams: angiotensin IItJe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] themet&interceding-token ngrams: addition , at'interceding-token ngrams: Takeda et al.tZe1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='pkczeta'] controlledtinterceding-token ngrams: . IntOe1: trigger-arg-path: Positive_activation >nn [lemma='pi'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >prep_between theme:FamilytHe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between Familyt/interceding-token ngrams: report indicated thatt)interceding-token ngrams: vascular smootht!interceding-token ngrams: inducedtPe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of Gene_or_gene_productt)interceding-token ngrams: a recent reportt)interceding-token ngrams: in rat vasculart$interceding-token ngrams: , a recenttYe1: trigger-arg-path: Positive_activation >prep_of [lemma='pkczeta'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >prep_between [lemma='ra'] theme:Familyt0interceding-token ngrams: induced ERK activationt>e1: ents2Label-mention-ngram: 3-Kgamma-dependent activation oftprep_between theme:Familyt#interceding-token ngrams: abrogatedtOe1: trigger-arg-path: Positive_activation >prep_of [lemma='pkczeta'] controlledt%interceding-token ngrams: induced ERKtIe1: trigger-arg-path: activation >prep_of controlled:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=activation >nn Gene_or_gene_producttinterceding-token ngrams: ett0e2: args2Role-mention-ngram: interaction betweent"interceding-token ngrams: ( Takedat&interceding-token ngrams: rat vasculartinterceding-token ngrams: al. )t(interceding-token ngrams: negative Ras (t+interceding-token ngrams: ERK activation intKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] FamilytRe1: trigger-arg-path: activation:Positive_activation >prep_of Gene_or_gene_productt-interceding-token ngrams: rat vascular smootht%interceding-token ngrams: In additiont'interceding-token ngrams: not abrogatedte1: trigger: activationt interceding-token ngrams: recenttde1: trigger-arg-path: Positive_activation >prep_of [lemma='pkczeta'] controlled:Gene_or_gene_productt"interceding-token ngrams: additiontZe1: trigger-arg-path: Positive_activation >nn [lemma='pi'] controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi'] controllert"interceding-token ngrams: a recenttnn [lemma='pi'] controllertGe2: trigger-arg-path: interaction >prep_between [lemma='pkczeta'] themet\e2: trigger-arg-path: interaction >prep_between [lemma='pkczeta'] theme:Gene_or_gene_productt*interceding-token ngrams: that angiotensint*interceding-token ngrams: not abrogated bytinterceding-token ngrams: , at'interceding-token ngrams: . In additiont/e1: trigger-arg-path: activation >nn controllertVe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between theme:Familyt;e1: ents2Label-mention-ngram: 3-Kgamma-dependent activationt:e1: args2Role-mention-ngram: CONTROLLER 3-Kgamma-dependentt'interceding-token ngrams: with dominanttTe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] themethe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pkczeta'] Gene_or_gene_producttXe2: trigger-arg-path: Binding >prep_between [lemma='pkczeta'] theme:Gene_or_gene_productt'interceding-token ngrams: recent reportt>e2: trigger-arg-path: interaction:Binding >prep_between Familyt interceding-token ngrams: in ratt9e1: trigger-arg-path: activation >nn Gene_or_gene_productt'interceding-token ngrams: smooth muscletJe2: trigger-arg-path: interaction >prep_between theme:Gene_or_gene_productt0interceding-token ngrams: vascular smooth musclet interceding-token ngrams: et al.tee1: trigger-arg-path: activation:Positive_activation >nn [lemma='pi'] controller:Gene_or_gene_productt(interceding-token ngrams: II induced ERKtXe1: trigger-arg-path: activation:Positive_activation >nn controller:Gene_or_gene_productt0interceding-token ngrams: angiotensin II inducedt interceding-token ngrams: ) . Int/interceding-token ngrams: muscle cells requirest5e2: trigger-arg-path: interaction >prep_between themetFe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of controlledtPe1: trigger-arg-path: activation:Positive_activation >nn [lemma='pi'] controllertFCSSPATH: ROOT >advcl >dobj >prep_via ++ ROOT >ccomp >dobj >rcmod >dobjt*e1: args2Role-mention-ngram: activation oft4interceding-token ngrams: indicated that angiotensintinterceding-token ngrams: Int>e1: trigger-arg-path: activation >prep_of Gene_or_gene_producttinterceding-token ngrams: rattde2: trigger-arg-path: interaction:Binding >prep_between [lemma='pkczeta'] theme:Gene_or_gene_producttFe1: trigger-arg-path: activation >nn [lemma='pi'] Gene_or_gene_producttRe1: trigger-arg-path: Positive_activation >prep_of controlled:Gene_or_gene_productt"interceding-token ngrams: vasculartwe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi'] controller:Gene_or_gene_productt&interceding-token ngrams: muscle cellstCe1: trigger-arg-path: activation:Positive_activation >nn controllert0interceding-token ngrams: with dominant negativetBe1: trigger-arg-path: Positive_activation >nn Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pkczeta'] theme:Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_between Gene_or_gene_producttinterceding-token ngrams: al.tFe1: trigger-arg-path: activation >prep_of [lemma='pkczeta'] controlledt/interceding-token ngrams: dominant negative RastNe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between theme:FamilytVe1: trigger-arg-path: lemmatizedTrigger=activation >nn controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=activation >prep_of controlled:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi'] controller:Gene_or_gene_producttEe1: trigger-arg-path: Positive_activation >nn [lemma='pi'] controllertPe1: trigger-arg-path: activation >prep_of [lemma='pkczeta'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='pkczeta'] controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: between FAMILYt[e1: trigger-arg-path: activation >prep_of [lemma='pkczeta'] controlled:Gene_or_gene_productt'interceding-token ngrams: activation int3interceding-token ngrams: abrogated by transfectiont%interceding-token ngrams: ( Takeda ett+interceding-token ngrams: transfection witht_e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn Gene_or_gene_productt interceding-token ngrams: Takedat6e2: trigger-arg-path: interaction >prep_between Familyt=e2: trigger-arg-path: interaction:Binding >prep_between themetde1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of Gene_or_gene_productt1interceding-token ngrams: recent report indicatedtCe2: trigger-arg-path: Binding >prep_between [lemma='pkczeta'] themetCe2: trigger-arg-path: interaction >prep_between [lemma='ra'] Familyt5e1: args2Role-mention-ngram: activation of CONTROLLEDt-interceding-token ngrams: smooth muscle cellst&interceding-token ngrams: Ras ( Takedate1: outgoing: >negtBe2: trigger-arg-path: interaction >prep_between [lemma='ra'] themet#interceding-token ngrams: Takeda ettRe2: trigger-arg-path: Binding >prep_between [lemma='pkczeta'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] theme:Familytle1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='pkczeta'] controlledtYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pkczeta'] themetinterceding-token ngrams: Ras (t$interceding-token ngrams: II inducedtEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 3-Kgamma-dependenttOe2: trigger-arg-path: interaction:Binding >prep_between [lemma='pkczeta'] themetUe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controllertve1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='pkczeta'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] Familyt&interceding-token ngrams: transfectiontZe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of controlledtXe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi'] Gene_or_gene_producttHe1: trigger-arg-path: activation:Positive_activation >prep_of controlledtPe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between Familyt%interceding-token ngrams: angiotensintQe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] theme:Familytpe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pkczeta'] Gene_or_gene_productt!interceding-token ngrams: al. ) .t0e1: ents2Label-mention-ngram: 3-Kgamma-dependentt2e1: ents2Label-mention-ngram: activation of SHAREDtVe2: trigger-arg-path: interaction >prep_between [lemma='pkczeta'] Gene_or_gene_productt=e1: trigger-arg-path: Positive_activation >prep_of controlledt&interceding-token ngrams: abrogated byt/e1: args2Role-mention-ngram: 3-Kgamma-dependenttPe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 3-Kgamma-dependent activationtoe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of controlled:Gene_or_gene_producttMe1: trigger-arg-path: activation:Positive_activation >nn Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='pkczeta'] controlledtRe2: trigger-arg-path: interaction:Binding >prep_between theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: between FAMILY andt)interceding-token ngrams: by transfectiont]e1: trigger-arg-path: activation:Positive_activation >prep_of controlled:Gene_or_gene_producttinterceding-token ngrams: IItEe1: args2Role-mention-ngram: CONTROLLER 3-Kgamma-dependent activationt?interceding-tokens-full-span: not abrogated by transfection with dominant negative Ras ( Takeda et al. ) . In addition , a recent report indicated that angiotensin II induced ERK activation in rat vascular smooth muscle cells requirest&interceding-token ngrams: negative Rast*interceding-token ngrams: report indicatedtMe1: trigger-arg-path: Positive_activation >nn controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] theme:FamilytDe2: trigger-arg-path: interaction >prep_between Gene_or_gene_producttIe2: trigger-arg-path: interaction >prep_between [lemma='ra'] theme:Familyt6e2: args2Role-mention-ngram: interaction between THEMEt(e2: ents2Label-mention-ngram: FAMILY andt interceding-token ngrams: muscletbe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi'] controllertUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] Familyt\e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] themet^e2: trigger-arg-path: interaction:Binding >prep_between [lemma='pkczeta'] Gene_or_gene_productt$interceding-token ngrams: addition ,tae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pkczeta'] themet"interceding-token ngrams: requirest interceding-token ngrams: smoothtbe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='pkczeta'] Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_between [lemma='ra'] FamilytGe1: trigger-arg-path: Positive_activation >prep_of Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=activation >nn controllertQe1: trigger-arg-path: activation >nn [lemma='pi'] controller:Gene_or_gene_producttDe1: trigger-arg-path: activation >nn controller:Gene_or_gene_productt(interceding-token ngrams: cells requirest?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='pkczeta'] controlled:Gene_or_gene_productt"interceding-token ngrams: et al. )t+interceding-token ngrams: activation in ratt4e1: trigger-arg-path: activation >prep_of controlledt4interceding-token ngrams: transfection with dominantt:e1: args2Role-mention-ngram: 3-Kgamma-dependent activationtDe2: trigger-arg-path: interaction:Binding >prep_between theme:Familyt2e2: trigger-arg-path: Binding >prep_between Familyt/e2: ents2Label-mention-ngram: FAMILY and SHAREDtje1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controller:Gene_or_gene_productt>e2: trigger-arg-path: Binding >prep_between [lemma='ra'] themetoe1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='pkczeta'] controlled:Gene_or_gene_productt-interceding-token ngrams: that angiotensin IIt'interceding-token ngrams: In addition ,tinterceding-token ngrams: ERKt.interceding-token ngrams: by transfection withtde1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='pkczeta'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pkczeta'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: activation oft1e2: ents2Label-mention-ngram: interaction betweent=e1: args2Role-mention-ngram: 3-Kgamma-dependent activation oft(interceding-token ngrams: ERK activationtZe1: trigger-arg-path: activation:Positive_activation >nn [lemma='pi'] Gene_or_gene_productt8e1: trigger-arg-path: Positive_activation >nn controllertZe2: trigger-arg-path: lemmatizedTrigger=require nn controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation nn controllert2e2: args2Role-mention-ngram: muscle cells requirest=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activationt-e2: ents2Label-mention-ngram: in rat vasculartwe2: trigger-arg-path: Positive_regulation nn [lemma='erk'] controller:Gene_or_gene_productt6e2: args2Role-mention-ngram: cells requires CONTROLLEDtce2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn Gene_or_gene_productt8e2: ents2Label-mention-ngram: cells requires interactiont]e2: trigger-arg-path: requires:Positive_regulation nn controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: smooth muscletre2: trigger-arg-path: lemmatizedTrigger=require nn [lemma='erk'] Gene_or_gene_productt*e2: args2Role-mention-ngram: activation int#e2: args2Role-mention-ngram: in ratt5e2: args2Role-mention-ngram: CONTROLLER activation int|e2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn [lemma='erk'] controllert&e2: ents2Label-mention-ngram: requirest e2: args2Role-mention-ngram: ratt,e2: args2Role-mention-ngram: in rat vasculartIe2: trigger-arg-path: requires nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn [lemma='erk'] controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: activationtHe2: trigger-arg-path: requires:Positive_regulation nn controllertke2: trigger-arg-path: requires:Positive_regulation nn [lemma='erk'] controllert1e2: ents2Label-mention-ngram: rat vascular smootht+e2: ents2Label-mention-ngram: activation int*e2: ents2Label-mention-ngram: rat vasculart$e2: ents2Label-mention-ngram: musclete2: trigger: requirest,e2: ents2Label-mention-ngram: cells requirest+e2: args2Role-mention-ngram: cells requirest(e2: ents2Label-mention-ngram: activationt2e2: ents2Label-mention-ngram: requires interactiont$e2: ents2Label-mention-ngram: smoothtle2: trigger-arg-path: requires nn [lemma='erk'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: muscle cells requirestEe2: trigger-arg-path: lemmatizedTrigger=require nn controllert4e2: ents2Label-mention-ngram: vascular smooth musclet>e2: trigger-arg-path: requires nn Gene_or_gene_productt4e2: trigger-arg-path: requires nn controllert)e2: args2Role-mention-ngram: rat vasculartRe2: trigger-arg-path: requires:Positive_regulation nn Gene_or_gene_productt*e2: ents2Label-mention-ngram: muscle cellst@CSSPATH: ROOT >advcl >dobj >prep_via ++ ROOT >ccomp >dobj >rcmodt#e2: args2Role-mention-ngram: musclet0e2: args2Role-mention-ngram: rat vascular smoothtue2: trigger-arg-path: requires:Positive_regulation nn [lemma='erk'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn [lemma='erk'] Gene_or_gene_productt#e2: args2Role-mention-ngram: smootht1e2: ents2Label-mention-ngram: smooth muscle cellstTe2: trigger-arg-path: Positive_regulation nn controller:Gene_or_gene_productt0e2: args2Role-mention-ngram: requires CONTROLLEDtWe2: trigger-arg-path: requires nn [lemma='erk'] controllert.e2: args2Role-mention-ngram: activation in ratt%e2: args2Role-mention-ngram: vasculartOe2: trigger-arg-path: lemmatizedTrigger=require nn Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER activationt3e2: args2Role-mention-ngram: vascular smooth musclet}e2: trigger-arg-path: lemmatizedTrigger=require nn [lemma='erk'] controller:Gene_or_gene_producttae2: trigger-arg-path: requires nn [lemma='erk'] Gene_or_gene_productt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activation intbe2: trigger-arg-path: Positive_regulation nn [lemma='erk'] controllert?interceding-tokens-full-span: not abrogated by transfection with dominant negative Ras ( Takeda et al. ) . In addition , a recent report indicated that angiotensin II inducedt-e2: ents2Label-mention-ngram: vascular smootht)e2: args2Role-mention-ngram: muscle cellst!e2: ents2Label-mention-ngram: ratt$e2: ents2Label-mention-ngram: in ratt/e2: ents2Label-mention-ngram: activation in ratt:e2: ents2Label-mention-ngram: requires interaction betweenthe2: trigger-arg-path: lemmatizedTrigger=require nn [lemma='erk'] controllert,e2: args2Role-mention-ngram: vascular smootht&e2: ents2Label-mention-ngram: vasculartne2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: smooth musclet?e2: trigger-arg-path: requires:Positive_regulation nn [lemma='erk'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation nn Gene_or_gene_productt%e2: args2Role-mention-ngram: requirest0e2: args2Role-mention-ngram: smooth muscle cellstYe2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation nn controllertle2: trigger-arg-path: Positive_regulation nn [lemma='erk'] Gene_or_gene_productt'e1: args2Role-mention-ngram: the lattert0e2: args2Role-mention-ngram: this inhibition butt)e2: args2Role-mention-ngram: affects AC ,t1e1: args2Role-mention-ngram: transiently inhibitstNe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >nn Gene_or_gene_productt-e2: args2Role-mention-ngram: receptor , whichtJe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_in controllerte2: args2Role-mention-ngram: 12t"e1: ents2Label-mention-ngram: upont#e2: ents2Label-mention-ngram: whicht,e1: args2Role-mention-ngram: CONTROLLER upontTe1: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] controlledt.e2: args2Role-mention-ngram: but even enhancest?e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='increase'] >prep_in [lemma='camp'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] Phosphorylationt3e2: trigger-arg-path: enhances >dobj >nn controlledt+e1: ents2Label-mention-ngram: of the lattert,interceding-token ngrams: Stimulation of thetve1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='increase'] >prep_in [lemma='camp'] Gene_or_gene_productt%e2: args2Role-mention-ngram: enhancest/e2: args2Role-mention-ngram: , which negativelytNe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn controllert7e2: args2Role-mention-ngram: counteract this inhibitiont[e2: trigger-arg-path: enhances:Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt0e2: args2Role-mention-ngram: enhances CONTROLLEDtwe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: only counteract thist6e2: ents2Label-mention-ngram: which negatively affectst8e1: args2Role-mention-ngram: latter receptor transientlytHe2: trigger-arg-path: Positive_activation >nsubj >prep_of >nn controllert0e1: args2Role-mention-ngram: upon stimulation oft?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: not onlytXe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >nn controlledtIe1: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] controlledt0e1: args2Role-mention-ngram: inhibits CONTROLLEDtte2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlled:Gene_or_gene_productt'e2: args2Role-mention-ngram: , does nott>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 12 receptortee1: trigger-arg-path: inhibits >nsubj [lemma='increase'] >prep_in [lemma='camp'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: only counteract thistSe1: trigger-arg-path: inhibits:Negative_regulation >dobj controlled:Phosphorylationt CSSPATH: ROOT  ++ ROOT >conj_butt&e2: args2Role-mention-ngram: AC , doestXe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn Gene_or_gene_productt?e2: trigger-arg-path: enhances >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlledt'e2: ents2Label-mention-ngram: AC , doest?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: , which negativelytRe2: trigger-arg-path: enhances >nsubj >prep_of >nn controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: but even enhancest.e1: ents2Label-mention-ngram: upon stimulationt%e2: ents2Label-mention-ngram: , whichte1: trigger: inhibitst3e2: ents2Label-mention-ngram: negatively affects ACt(interceding-token ngrams: Stimulation oft?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controller:Gene_or_gene_productt0e2: args2Role-mention-ngram: not only counteracttze2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='pkb'] controlled:Gene_or_gene_productt1e2: ents2Label-mention-ngram: inhibition but event(e2: ents2Label-mention-ngram: , does notthe2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlledt*e2: args2Role-mention-ngram: 12 receptor ,t-e2: ents2Label-mention-ngram: enhances SHAREDt$e2: ents2Label-mention-ngram: , doest-e2: ents2Label-mention-ngram: this inhibitiont&e2: ents2Label-mention-ngram: enhanceste2: trigger-arg-path: Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controllert:e1: trigger-arg-path: Negative_regulation >dobj controlledt9e1: ents2Label-mention-ngram: transiently inhibits SHAREDtpe1: trigger-arg-path: inhibits >nsubj [lemma='increase'] >prep_in [lemma='camp'] controller:Gene_or_gene_productte2: trigger: enhancest_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_in controller:Gene_or_gene_productt e2: ents2Label-mention-ngram: ACt5e2: args2Role-mention-ngram: which negatively affectstCe1: trigger-arg-path: inhibits >nsubj >prep_in Gene_or_gene_producttCe1: trigger-arg-path: inhibits:Negative_regulation >dobj controlledtne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlledt"e2: ents2Label-mention-ngram: onlyt/e1: args2Role-mention-ngram: stimulation of thet}e2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlled:Gene_or_gene_producttye1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] Gene_or_gene_producttie2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] Gene_or_gene_producttYe1: trigger-arg-path: Negative_regulation >nsubj >prep_in controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: only counteractt)e1: ents2Label-mention-ngram: stimulationtPe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:Phosphorylationt)e1: ents2Label-mention-ngram: transientlyt%interceding-token ngrams: StimulationtTe2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='pkb'] controlledt,e2: args2Role-mention-ngram: this inhibitiont?e2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controller:Gene_or_gene_producttJe1: trigger-arg-path: Negative_regulation >dobj controlled:Phosphorylationt]e2: trigger-arg-path: Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: , whichtYe1: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] controlled:Phosphorylationt%e2: ents2Label-mention-ngram: affectst(e2: ents2Label-mention-ngram: inhibitiont4e1: trigger-arg-path: inhibits >dobj PhosphorylationtHe2: trigger-arg-path: enhances >dobj >nn controlled:Gene_or_gene_productt-e1: args2Role-mention-ngram: upon stimulationtRe2: trigger-arg-path: Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt2e1: ents2Label-mention-ngram: receptor transientlyt+e2: ents2Label-mention-ngram: 12 receptor ,t5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 12t+e1: args2Role-mention-ngram: stimulation oft'e2: args2Role-mention-ngram: inhibitiont!e2: args2Role-mention-ngram: AC ,t,e2: args2Role-mention-ngram: only counteracttte2: trigger-arg-path: enhances >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controllert-e2: ents2Label-mention-ngram: counteract thistfe1: trigger-arg-path: Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controllert,e1: args2Role-mention-ngram: latter receptorte2: args2Role-mention-ngram: ACt'interceding-token ngrams: . Stimulationt(e2: ents2Label-mention-ngram: receptor ,t!e1: args2Role-mention-ngram: upontGe2: trigger-arg-path: enhances >nsubj >prep_of >nn Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlled:Phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >nn controlled:Gene_or_gene_productt%e2: args2Role-mention-ngram: but event*e1: args2Role-mention-ngram: of the lattertnsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] Gene_or_gene_productt*e2: args2Role-mention-ngram: even enhancest(e2: ents2Label-mention-ngram: negativelytee2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='pkb'] controlledt*e2: args2Role-mention-ngram: does not onlyt{e1: trigger-arg-path: Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: , doest0e1: ents2Label-mention-ngram: stimulation of thetpe1: trigger-arg-path: Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] Gene_or_gene_producttDe1: trigger-arg-path: Negative_regulation >nsubj >prep_in controllert?e1: trigger-arg-path: inhibits >dobj controlled:PhosphorylationtQe2: trigger-arg-path: enhances:Positive_activation >dobj >nn Gene_or_gene_productt(e1: args2Role-mention-ngram: stimulationt!e2: args2Role-mention-ngram: eventme1: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtEe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Phosphorylationt'e2: args2Role-mention-ngram: negativelyt2interceding-tokens-full-span: . Stimulation of thet#e1: args2Role-mention-ngram: of thet?e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controllert0e2: args2Role-mention-ngram: inhibition but event?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlled:Gene_or_gene_producttQe2: trigger-arg-path: enhances:Positive_activation >nsubj >prep_of >nn controllertGe2: trigger-arg-path: enhances:Positive_activation >dobj >nn controlledt~e2: trigger-arg-path: enhances >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj Phosphorylationt2e2: args2Role-mention-ngram: negatively affects ACt.e2: ents2Label-mention-ngram: receptor , whichtbe1: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt,e2: ents2Label-mention-ngram: inhibition butt)e2: ents2Label-mention-ngram: 12 receptort?e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] Gene_or_gene_productt(e1: args2Role-mention-ngram: transientlytye2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] controlledt$e1: ents2Label-mention-ngram: lattert+e2: args2Role-mention-ngram: inhibition butt(e2: ents2Label-mention-ngram: affects ACt1e1: args2Role-mention-ngram: receptor transientlyt3e2: args2Role-mention-ngram: CONTROLLER 12 receptortse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controllert*interceding-token ngrams: . Stimulation oft8e1: args2Role-mention-ngram: CONTROLLER upon stimulationt&e2: ents2Label-mention-ngram: but event+e2: ents2Label-mention-ngram: even enhancest#e1: args2Role-mention-ngram: lattertZe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] controlledt-e1: ents2Label-mention-ngram: inhibits SHAREDtNe1: trigger-arg-path: Negative_regulation >nsubj >prep_in Gene_or_gene_productt%e2: args2Role-mention-ngram: receptortNe1: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] Phosphorylationt[e1: trigger-arg-path: inhibits >nsubj [lemma='increase'] >prep_in [lemma='camp'] controllertle2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt2e2: ents2Label-mention-ngram: even enhances SHAREDt'e2: args2Role-mention-ngram: affects ACt1e1: ents2Label-mention-ngram: the latter receptortCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upon stimulationt+e2: ents2Label-mention-ngram: does not onlyt(e2: ents2Label-mention-ngram: counteractt?e2: trigger-arg-path: Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: which negativelyt1e2: ents2Label-mention-ngram: this inhibition butt"e2: ents2Label-mention-ngram: AC ,tDe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >nn controlledt@e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlledtfe2: trigger-arg-path: enhances:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: counteract thist$e2: args2Role-mention-ngram: affectst*e2: ents2Label-mention-ngram: affects AC ,t?e1: trigger-arg-path: Negative_regulation >dobj Phosphorylationt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upont9e1: trigger-arg-path: inhibits >nsubj >prep_in controllert1e1: ents2Label-mention-ngram: upon stimulation oft'e2: args2Role-mention-ngram: counteractt^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_in controllertoe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controllert,e1: ents2Label-mention-ngram: stimulation oft"e2: ents2Label-mention-ngram: event0e2: ents2Label-mention-ngram: negatively affectst=e1: ents2Label-mention-ngram: inhibits SHARED phosphorylationt2e1: ents2Label-mention-ngram: transiently inhibitst/e1: trigger-arg-path: inhibits >dobj controlledt%e1: args2Role-mention-ngram: receptort9e1: ents2Label-mention-ngram: latter receptor transientlyt^e2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='pkb'] Gene_or_gene_productt0e1: args2Role-mention-ngram: the latter receptort?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controllertbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >prep_of >nn controllert=e2: trigger-arg-path: enhances >dobj >nn Gene_or_gene_productt1e2: ents2Label-mention-ngram: not only counteracttYe1: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt%e2: args2Role-mention-ngram: not onlytde1: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt(e2: args2Role-mention-ngram: 12 receptort e2: ents2Label-mention-ngram: 12t/e2: args2Role-mention-ngram: negatively affectstHe1: trigger-arg-path: inhibits:Negative_regulation >dobj Phosphorylationt!e2: args2Role-mention-ngram: onlyt:e1: args2Role-mention-ngram: receptor transiently inhibitstie2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='pkb'] controlled:Gene_or_gene_producttbe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_in controller:Gene_or_gene_productt=e2: trigger-arg-path: enhances >nsubj >prep_of >nn controllerthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_in Gene_or_gene_producttre2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='pkb'] Gene_or_gene_productt*e2: args2Role-mention-ngram: CONTROLLER 12tYe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >nn controlled:Gene_or_gene_productt&e1: ents2Label-mention-ngram: receptortse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_in controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: receptort(e1: ents2Label-mention-ngram: the lattertMe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_in controllertoe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='pkb'] Gene_or_gene_productt?e2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] controllert5e2: args2Role-mention-ngram: even enhances CONTROLLEDt"e2: args2Role-mention-ngram: whicht]e1: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] controlledt\e2: trigger-arg-path: enhances:Positive_activation >dobj >nn controlled:Gene_or_gene_productt-e1: ents2Label-mention-ngram: latter receptort8e2: ents2Label-mention-ngram: counteract this inhibitiontTe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_in Gene_or_gene_producttNe1: trigger-arg-path: inhibits >nsubj >prep_in controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >nn Gene_or_gene_productt=e1-label: Negative_regulation + e2-label: Positive_activationtle1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='increase'] >prep_in [lemma='camp'] controllert~e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] >nn [lemma='p2y'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='increase'] >prep_in [lemma='camp'] controller:Gene_or_gene_producttWe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_in Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlledt7e2: ents2Label-mention-ngram: increased phosphorylationt,e1: ents2Label-mention-ngram: phosphorylatedt|e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='factor'] controller:Gene_or_gene_producttinterceding-token ngrams: p38t.e2: ents2Label-mention-ngram: exogenous SHAREDt$interceding-token ngrams: but not byt`e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >agent [lemma='erk'] controllert1e2: args2Role-mention-ngram: anisomycin increasedtYe1: trigger-arg-path: phosphorylated >agent [lemma='erk'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: SHARED wast*e2: ents2Label-mention-ngram: of exogenoustpe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: or anisomycin increasedt+e2: ents2Label-mention-ngram: or anisomycint!interceding-token ngrams: and p38t2e2: ents2Label-mention-ngram: anisomycin increasedtSe1: trigger-arg-path: Positive_regulation >agent [lemma='erk'] Gene_or_gene_productt:e2: ents2Label-mention-ngram: phosphorylation of exogenoustDe1: trigger-arg-path: phosphorylated >agent [lemma='erk'] controllert interceding-token ngrams: NIH3T3t!e1: ents2Label-mention-ngram: wastGe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent controllert]e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='factor'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='factor'] controllert3e1: ents2Label-mention-ngram: was phosphorylated byt&interceding-token ngrams: NIH3T3 cellst interceding-token ngrams: by JNKtVe2: trigger-arg-path: Positive_regulation >nsubj [lemma='factor'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: exogenoustje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='erk'] controller:Gene_or_gene_productte1: trigger: phosphorylatedtqe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='factor'] Gene_or_gene_productt*e1: args2Role-mention-ngram: by CONTROLLERtagent [lemma='erk'] controller:Gene_or_gene_productt!interceding-token ngrams: cells ,tLe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='erk'] Gene_or_gene_producttDe1: ents2Label-mention-ngram: phosphorylated by GENE_OR_GENE_PRODUCTt;e2: trigger-arg-path: increased >nsubj Gene_or_gene_productt5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ort(interceding-token ngrams: NIH3T3 cells ,t\e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent controller:Gene_or_gene_productt1e2: trigger-arg-path: increased >nsubj controllertEe1: trigger-arg-path: Positive_regulation >agent Gene_or_gene_productt:e2: ents2Label-mention-ngram: increased phosphorylation oft0e1: ents2Label-mention-ngram: was phosphorylatedtTe1: trigger-arg-path: phosphorylated:Positive_regulation >agent Gene_or_gene_productt;e1: trigger-arg-path: Positive_regulation >agent controllertUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='erk'] controllertBe2: trigger-arg-path: increased >nsubj [lemma='factor'] controllertae2: trigger-arg-path: Positive_regulation >nsubj [lemma='factor'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controllert1e2: ents2Label-mention-ngram: of exogenous SHAREDtCSSPATH: ROOT >ccomp ++ ROOT t(e2: ents2Label-mention-ngram: anisomycint7e1: ents2Label-mention-ngram: SHARED was phosphorylatedt"interceding-token ngrams: JNK . Int'e2: args2Role-mention-ngram: anisomycintme1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='erk'] controller:Gene_or_gene_productt_e1: trigger-arg-path: phosphorylated:Positive_regulation >agent controller:Gene_or_gene_producttLe2: trigger-arg-path: increased >nsubj [lemma='factor'] Gene_or_gene_productt interceding-token ngrams: not bytVe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='factor'] controllert#interceding-token ngrams: In NIH3T3tNe1: trigger-arg-path: phosphorylated >agent [lemma='erk'] Gene_or_gene_producttOe2: trigger-arg-path: increased:Positive_regulation >nsubj Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent Gene_or_gene_producttXe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='erk'] controllert@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT or anisomycint%interceding-token ngrams: . In NIH3T3tLe2: trigger-arg-path: Positive_regulation >nsubj [lemma='factor'] controllert5e1: args2Role-mention-ngram: CONTROLLED by CONTROLLERtFe2: trigger-arg-path: increased >nsubj controller:Gene_or_gene_producttinterceding-token ngrams: JNKt!interceding-token ngrams: p38 butt4e2: args2Role-mention-ngram: or anisomycin increasedt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent controllertEe2: trigger-arg-path: increased:Positive_regulation >nsubj controllertWe2: trigger-arg-path: increased >nsubj [lemma='factor'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='erk'] controllertee1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent Gene_or_gene_producttJe1: trigger-arg-path: phosphorylated:Positive_regulation >agent controllertHinterceding-tokens-full-span: and p38 but not by JNK . In NIH3T3 cells ,t)interceding-token ngrams: In NIH3T3 cellstke2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: by JNK .t*e2: args2Role-mention-ngram: CONTROLLER ortbe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='erk'] Gene_or_gene_productt$interceding-token ngrams: not by JNKtke2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='factor'] controller:Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >agent [lemma='erk'] controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='factor'] controller:Gene_or_gene_producttZe2: trigger-arg-path: increased:Positive_regulation >nsubj controller:Gene_or_gene_productt6e1: trigger-arg-path: phosphorylated >agent controllerte1: incoming: nsubj [lemma='factor'] controllert%interceding-token ngrams: p38 but nott5e1: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCTtWe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj controller:Gene_or_gene_producttKe1: trigger-arg-path: phosphorylated >agent controller:Gene_or_gene_productte2: trigger: increasedtPe1: trigger-arg-path: Positive_regulation >agent controller:Gene_or_gene_productt@e1: trigger-arg-path: phosphorylated >agent Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj controllert_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='erk'] Gene_or_gene_producttBe2: ents2Label-mention-ngram: anisomycin increased phosphorylationt`e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='factor'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tie2'] themet'interceding-token ngrams: this receptort-interceding-token ngrams: this receptor undert$interceding-token ngrams: associatedt@e1: trigger-arg-path: binds:Binding >nsubj [lemma='ang-2'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ang-2'] themet'interceding-token ngrams: physiologicalt interceding-token ngrams: vesseltMe1: trigger-arg-path: binds >nsubj [lemma='ang-2'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ang-2'] themet0interceding-token ngrams: vessel destabilizationt?e2: trigger-arg-path: inhibits >dobj [lemma='foxo1'] controlledtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='foxo1'] Gene_or_gene_productt9e2: trigger-arg-path: inhibits >dobj Gene_or_gene_producttUe2: trigger-arg-path: inhibits >nsubj [lemma='Ang-1'] controller:Gene_or_gene_productt+interceding-token ngrams: conditions and ist'interceding-token ngrams: remodelling .t`e2: trigger-arg-path: Negative_activation >nsubj [lemma='Ang-1'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: alsotTe2: trigger-arg-path: Negative_activation >dobj [lemma='foxo1'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tie2'] themet6interceding-token ngrams: consequently associated withtQe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='Ang-1'] controllert2interceding-token ngrams: physiological conditionstEe2: trigger-arg-path: inhibits >nsubj controller:Gene_or_gene_productt&interceding-token ngrams: consequentlytNe1: trigger-arg-path: binds >prep_to [lemma='tie2'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='Ang-1'] Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER inhibitst)interceding-token ngrams: is consequentlytJe2: trigger-arg-path: inhibits >nsubj [lemma='Ang-1'] Gene_or_gene_productt1interceding-token ngrams: consequently associatedtTe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='Ang-1'] controllert"interceding-token ngrams: activatetSe2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='foxo1'] controlledt8e1: trigger-arg-path: binds >nsubj [lemma='ang-2'] themetoe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='Ang-1'] Gene_or_gene_productt@e2: trigger-arg-path: inhibits >nsubj [lemma='Ang-1'] controllert_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tie2'] theme:Gene_or_gene_productt0interceding-token ngrams: activate this receptortHe1: trigger-arg-path: binds >prep_to [lemma='tie2'] Gene_or_gene_productt9interceding-token ngrams: destabilization and remodellingt-interceding-token ngrams: destabilization andtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tie2'] Gene_or_gene_producttCe2: trigger-arg-path: inhibits:Negative_activation >dobj controlledt/e2: trigger-arg-path: inhibits >dobj controlledt4interceding-token ngrams: vessel destabilization andtXe2: trigger-arg-path: inhibits:Negative_activation >dobj controlled:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj Gene_or_gene_producttie2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='Ang-1'] controller:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='tie2'] theme:Gene_or_gene_productt:e2: trigger-arg-path: inhibits >nsubj Gene_or_gene_productt$interceding-token ngrams: with bloodtYe2: trigger-arg-path: inhibits:Negative_activation >nsubj controller:Gene_or_gene_productt(interceding-token ngrams: conditions andt(e1: ents2Label-mention-ngram: also bindstTe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj controlledtinterceding-token ngrams: undert*e1: args2Role-mention-ngram: also binds tot`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ang-2'] Gene_or_gene_productt-interceding-token ngrams: under physiologicalt+interceding-token ngrams: with blood vesseltee2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='Ang-1'] controllertJe1: trigger-arg-path: Binding >prep_to [lemma='tie2'] Gene_or_gene_producttUe2: trigger-arg-path: Negative_activation >nsubj [lemma='Ang-1'] Gene_or_gene_productt]e2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='foxo1'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT alsotAe1: trigger-arg-path: binds:Binding >prep_to [lemma='tie2'] themetUe1: trigger-arg-path: binds:Binding >nsubj [lemma='ang-2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >nsubj [lemma='ang-2'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='tie2'] themetDe2: trigger-arg-path: inhibits:Negative_activation >nsubj controllert6interceding-token ngrams: blood vessel destabilizationt/interceding-token ngrams: associated with bloodtOe1: trigger-arg-path: Binding >nsubj [lemma='ang-2'] theme:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlledtPe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibits GENE_OR_GENE_PRODUCTt'e1: args2Role-mention-ngram: THEME alsotXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ang-2'] Gene_or_gene_productt'e1: args2Role-mention-ngram: also bindst-e1: args2Role-mention-ngram: THEME also bindstNe2: trigger-arg-path: inhibits:Negative_activation >nsubj Gene_or_gene_productt4interceding-token ngrams: is consequently associatedt interceding-token ngrams: and ist)interceding-token ngrams: and remodellingt6interceding-token ngrams: physiological conditions andt6interceding-token ngrams: receptor under physiologicaltYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tie2'] Gene_or_gene_producttGe1: trigger-arg-path: binds >nsubj [lemma='ang-2'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controllert+interceding-token ngrams: and remodelling .t:e1: trigger-arg-path: Binding >nsubj [lemma='ang-2'] themet!interceding-token ngrams: it doest0e2: args2Role-mention-ngram: inhibits CONTROLLEDt&interceding-token ngrams: blood vesseltPe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='foxo1'] controlledtJe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Gene_or_gene_producttCSSPATH: ROOT >advcl ++ ROOT t)interceding-token ngrams: associated withtVe1: trigger-arg-path: binds:Binding >prep_to [lemma='tie2'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='ang-2'] Gene_or_gene_producttTe2: trigger-arg-path: inhibits >dobj [lemma='foxo1'] controlled:Gene_or_gene_producttMe2: trigger-arg-path: inhibits:Negative_activation >dobj Gene_or_gene_producttinterceding-token ngrams: bloodtye2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='foxo1'] controlled:Gene_or_gene_productt)interceding-token ngrams: destabilizationtDe2: trigger-arg-path: inhibits >dobj controlled:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibitst"e1: ents2Label-mention-ngram: alsot;e2: args2Role-mention-ngram: CONTROLLER inhibits CONTROLLEDt(interceding-token ngrams: receptor undert#interceding-token ngrams: , it doesthe2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='foxo1'] controlled:Gene_or_gene_productt+interceding-token ngrams: does not activatet-interceding-token ngrams: and is consequentlyt+interceding-token ngrams: not activate thist8interceding-token ngrams: under physiological conditionstJe2: trigger-arg-path: Negative_activation >dobj [lemma='foxo1'] controlledt%e2: args2Role-mention-ngram: inhibitstze2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='Ang-1'] controller:Gene_or_gene_productt?interceding-tokens-full-span: , it does not activate this receptor under physiological conditions and is consequently associated with blood vessel destabilization and remodelling .tfe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='Ang-1'] controller:Gene_or_gene_productt'interceding-token ngrams: activate thist_e2: trigger-arg-path: Negative_activation >dobj [lemma='foxo1'] controlled:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='foxo1'] controlled:Gene_or_gene_productt%interceding-token ngrams: remodellingtZe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='foxo1'] Gene_or_gene_producttIe2: trigger-arg-path: inhibits >dobj [lemma='foxo1'] Gene_or_gene_productt$interceding-token ngrams: conditionst0e2: trigger-arg-path: inhibits >nsubj controllertge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tie2'] theme:Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also bindstie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:Gene_or_gene_productt9e1: trigger-arg-path: binds >prep_to [lemma='tie2'] themet"interceding-token ngrams: does nottUe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ang-2'] theme:Gene_or_gene_productt;e2: ents2Label-mention-ngram: inhibits GENE_OR_GENE_PRODUCTtKe2: trigger-arg-path: Negative_activation >nsubj [lemma='Ang-1'] controllert&interceding-token ngrams: not activatet^e2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='Ang-1'] Gene_or_gene_producttinterceding-token ngrams: doestde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='foxo1'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ang-2'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: also binds totPe1: trigger-arg-path: binds:Binding >prep_to [lemma='tie2'] Gene_or_gene_productt%interceding-token ngrams: it does notte2: trigger: inhibitst&e2: ents2Label-mention-ngram: inhibitst3e2: args2Role-mention-ngram: CONTROLLER selectivelyt,e1: args2Role-mention-ngram: physiologicallytAe1: trigger-arg-path: target:Binding >nsubj [lemma='mek-1'] themet_e2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='a-raf'] Gene_or_gene_producttOe2: trigger-arg-path: activated:Positive_activation >nsubj Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='a-raf'] Gene_or_gene_productt$interceding-token ngrams: Hela cellst"interceding-token ngrams: from MEKthe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='mek-1'] theme:Gene_or_gene_productt&interceding-token ngrams: MEK isoformstVe1: trigger-arg-path: target:Binding >nsubj [lemma='mek-1'] theme:Gene_or_gene_productt=e1: ents2Label-mention-ngram: physiologically relevant targett"interceding-token ngrams: scenariot)e2: ents2Label-mention-ngram: selectivelyt8e1: ents2Label-mention-ngram: a physiologically relevanttQe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='mek-1'] controlledtEe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of themetTe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of Gene_or_gene_producttTe2: trigger-arg-path: activated:Positive_activation >dobj [lemma='mek-1'] controlledtinterceding-token ngrams: Helat$interceding-token ngrams: , but alsot>e1: trigger-arg-path: target >nsubj theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: a physiologicallytRe1: trigger-arg-path: target:Binding >prep_of [lemma='raf-1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='a-raf'] controllert1e1-label: Binding + e2-label: Positive_activationt{e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='a-raf'] controller:Gene_or_gene_producttEe2: trigger-arg-path: activated >dobj controlled:Gene_or_gene_productt=e1: trigger-arg-path: lemmatizedTrigger=target >prep_of themet'e1: args2Role-mention-ngram: THEME is atKe2: trigger-arg-path: Positive_activation >nsubj [lemma='a-raf'] controllertNe2: trigger-arg-path: activated:Positive_activation >dobj Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='mek-1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: target >prep_of [lemma='raf-1'] Gene_or_gene_producttYe2: trigger-arg-path: activated:Positive_activation >dobj controlled:Gene_or_gene_productt,e1: args2Role-mention-ngram: target of THEMEt[e2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='mek-1'] Gene_or_gene_producttKe2: trigger-arg-path: activated >nsubj [lemma='a-raf'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='raf-1'] themetprep_of [lemma='raf-1'] themet8e1: trigger-arg-path: target >nsubj Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=target >prep_of theme:Gene_or_gene_productt9e1: trigger-arg-path: target >nsubj [lemma='mek-1'] themet;e1: trigger-arg-path: lemmatizedTrigger=target >nsubj themetIe1: trigger-arg-path: Binding >nsubj [lemma='mek-1'] Gene_or_gene_producttXe1: trigger-arg-path: target:Binding >prep_of [lemma='raf-1'] theme:Gene_or_gene_productt&interceding-token ngrams: Hela cells ,t-e1: ents2Label-mention-ngram: relevant targett%interceding-token ngrams: also pointst`e2: trigger-arg-path: Positive_activation >nsubj [lemma='a-raf'] controller:Gene_or_gene_productt?interceding-tokens-full-span: , but also points to a more complicated scenario where signals diversify from MEK isoforms . Indeed , in Hela cells ,tze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='mek-1'] controlled:Gene_or_gene_productt)e1: trigger-arg-path: target >nsubj themetinterceding-token ngrams: moret.interceding-token ngrams: complicated scenariot(e2: args2Role-mention-ngram: selectivelyt'e1: ents2Label-mention-ngram: SHARED ist0e2: trigger-arg-path: activated >dobj controlledt3e2: ents2Label-mention-ngram: selectively activatedtbe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='raf-1'] theme:Gene_or_gene_productt"interceding-token ngrams: but alsot_e2: trigger-arg-path: Positive_activation >dobj [lemma='mek-1'] controlled:Gene_or_gene_producttinterceding-token ngrams: , int@e1: trigger-arg-path: target >prep_of theme:Gene_or_gene_producttinterceding-token ngrams: wheretinterceding-token ngrams: fromtBe1: trigger-arg-path: target:Binding >prep_of Gene_or_gene_producttNe1: trigger-arg-path: target >nsubj [lemma='mek-1'] theme:Gene_or_gene_productt4interceding-token ngrams: complicated scenario wheretoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='mek-1'] Gene_or_gene_productt%interceding-token ngrams: complicatedt"e1: ents2Label-mention-ngram: is at)e1: ents2Label-mention-ngram: SHARED is at/e1: args2Role-mention-ngram: relevant target oft3e1: trigger-arg-path: target:Binding >prep_of themet3interceding-token ngrams: more complicated scenariote1: trigger: targettHe1: trigger-arg-path: target >nsubj [lemma='mek-1'] Gene_or_gene_productt*interceding-token ngrams: more complicatedtUe2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='a-raf'] controllertZe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='mek-1'] Gene_or_gene_productt'interceding-token ngrams: where signalstKe1: trigger-arg-path: Binding >prep_of [lemma='raf-1'] Gene_or_gene_productt(interceding-token ngrams: also points totHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT selectively activatedt+interceding-token ngrams: signals diversifyt1e2: trigger-arg-path: activated >nsubj controllert.e2: ents2Label-mention-ngram: activated SHAREDt1e2: args2Role-mention-ngram: activated CONTROLLEDt:e2: ents2Label-mention-ngram: selectively activated SHAREDtTe2: trigger-arg-path: Positive_activation >dobj [lemma='mek-1'] Gene_or_gene_productt1interceding-token ngrams: where signals diversifyt#interceding-token ngrams: diversifyt!interceding-token ngrams: signalstde1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='raf-1'] Gene_or_gene_productt$interceding-token ngrams: isoforms .t6e1: ents2Label-mention-ngram: physiologically relevanttie2: trigger-arg-path: activated:Positive_activation >dobj [lemma='mek-1'] controlled:Gene_or_gene_producttDe2: trigger-arg-path: activated:Positive_activation >dobj controlledtPe1: trigger-arg-path: target:Binding >nsubj [lemma='mek-1'] Gene_or_gene_productt+interceding-token ngrams: isoforms . Indeedte1: ents2Label-mention-ngram: at interceding-token ngrams: pointst-e1: ents2Label-mention-ngram: physiologicallyt e1: ents2Label-mention-ngram: ist>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT selectivelyt0e1: ents2Label-mention-ngram: relevant target oft+interceding-token ngrams: from MEK isoformst"interceding-token ngrams: isoformstFe1: trigger-arg-path: target:Binding >nsubj theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: physiologically relevanttee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='mek-1'] controlledt\e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='a-raf'] Gene_or_gene_productt,interceding-token ngrams: diversify from MEKt=e2: args2Role-mention-ngram: CONTROLLER selectively activatedt@e2: trigger-arg-path: activated >dobj [lemma='mek-1'] controlledtPe1: trigger-arg-path: lemmatizedTrigger=target >nsubj theme:Gene_or_gene_productt1e1: trigger-arg-path: target:Binding >nsubj themet'interceding-token ngrams: in Hela cellstfe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='mek-1'] controlled:Gene_or_gene_productte1: args2Role-mention-ngram: istAe2: trigger-arg-path: activated >nsubj [lemma='a-raf'] controllert.e1: args2Role-mention-ngram: a physiologicallyt%e1: args2Role-mention-ngram: relevantt2e1: ents2Label-mention-ngram: is a physiologicallyt!interceding-token ngrams: in Helat:e1: trigger-arg-path: Binding >nsubj [lemma='mek-1'] themetje2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='a-raf'] controller:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=target >nsubj Gene_or_gene_productt0interceding-token ngrams: scenario where signalst%interceding-token ngrams: points to at#interceding-token ngrams: points tot&e1: ents2Label-mention-ngram: relevantt:e1: trigger-arg-path: target >prep_of Gene_or_gene_producttinterceding-token ngrams: alsot$e1: ents2Label-mention-ngram: targettSe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='mek-1'] themet0interceding-token ngrams: signals diversify fromt+e1: trigger-arg-path: target >prep_of themetUe2: trigger-arg-path: Positive_activation >nsubj [lemma='a-raf'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='mek-1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj Gene_or_gene_producttFe2: trigger-arg-path: activated >nsubj controller:Gene_or_gene_productt#interceding-token ngrams: , in Helat(interceding-token ngrams: MEK isoforms .tVe2: trigger-arg-path: activated >nsubj [lemma='a-raf'] controller:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='raf-1'] themet%interceding-token ngrams: Indeed , intZe2: trigger-arg-path: activated:Positive_activation >nsubj controller:Gene_or_gene_producttprep_of [lemma='raf-1'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: is at1e1: args2Role-mention-ngram: is a physiologicallyt#interceding-token ngrams: to a morete1: args2Role-mention-ngram: ate2: trigger: activatedtHe1: trigger-arg-path: target:Binding >prep_of theme:Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >dobj [lemma='mek-1'] controlledt%e1: args2Role-mention-ngram: THEME ist@e1: trigger-arg-path: target:Binding >nsubj Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='raf-1'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: target oft=e2: args2Role-mention-ngram: selectively activated CONTROLLEDt;e2: trigger-arg-path: activated >nsubj Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=target >prep_of Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_of [lemma='raf-1'] theme:Gene_or_gene_producttPe1: trigger-arg-path: target >prep_of [lemma='raf-1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='a-raf'] controllert:e2: trigger-arg-path: activated >dobj Gene_or_gene_productt(interceding-token ngrams: diversify fromtge2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='a-raf'] controller:Gene_or_gene_productt interceding-token ngrams: a moret(interceding-token ngrams: scenario wheretinterceding-token ngrams: MEKtCe1: trigger-arg-path: target:Binding >prep_of [lemma='raf-1'] themet,e1: args2Role-mention-ngram: relevant targettbe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='mek-1'] Gene_or_gene_productt2e2: args2Role-mention-ngram: selectively activatedt#e1: args2Role-mention-ngram: targettprep_of [lemma='raf-1'] themet7e1: args2Role-mention-ngram: a physiologically relevantt'e1: ents2Label-mention-ngram: target oftJe2: trigger-arg-path: activated >dobj [lemma='mek-1'] Gene_or_gene_productt^e2: trigger-arg-path: activated:Positive_activation >dobj [lemma='mek-1'] Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj themetinterceding-token ngrams: , buttKe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='mek-1'] themet)interceding-token ngrams: but also pointstEe2: trigger-arg-path: activated:Positive_activation >nsubj controllert,interceding-token ngrams: a more complicatedtUe2: trigger-arg-path: activated >dobj [lemma='mek-1'] controlled:Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='ksr'] themet:e1: trigger-arg-path: Binding >prep_to [lemma='mek'] themet%interceding-token ngrams: response totGe1: trigger-arg-path: binds >prep_to [lemma='mek'] Gene_or_gene_productt/interceding-token ngrams: mitogenic stimulationtSe1: trigger-arg-path: binds:Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_productt;e2: trigger-arg-path: complex prep_to [lemma='mek'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_producttEe1: trigger-arg-path: binds >nsubj [lemma='ksr'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_to [lemma='mek'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: constitutively bindstPe2: trigger-arg-path: Binding prep_to [lemma='mek'] theme:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='mek'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mek'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED constitutivelytde2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='mek'] themetXe2: trigger-arg-path: complex:Binding nsubj [lemma='ksr'] Gene_or_gene_productt;e2: trigger-arg-path: Binding nn [lemma='mek'] themetMe1: trigger-arg-path: binds >prep_to [lemma='mek'] theme:Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='mek'] Gene_or_gene_producttKe1: trigger-arg-path: binds >nsubj [lemma='ksr'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='mek'] themetJe2: trigger-arg-path: complex nsubj [lemma='ksr'] themetJe2: trigger-arg-path: Binding >nn [lemma='mek'] theme:Gene_or_gene_productt8e1: trigger-arg-path: binds >prep_to [lemma='mek'] themetGe1: trigger-arg-path: Binding >nsubj [lemma='ksr'] Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding >nn [lemma='mek'] theme:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mek'] themetJe2: trigger-arg-path: complex >nn [lemma='mek'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mek'] themet!CSSPATH: ROOT  ++ ROOT >nsubjpasstUe1: trigger-arg-path: binds:Binding >prep_to [lemma='mek'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_to [lemma='mek'] theme:Gene_or_gene_producttJinterceding-tokens-full-span: . In response to mitogenic stimulation , thet&interceding-token ngrams: to mitogenictDe2: trigger-arg-path: Binding >nn [lemma='mek'] Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='ksr'] themetje2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj [lemma='ksr'] themetOe1: trigger-arg-path: binds:Binding >prep_to [lemma='mek'] Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding prep_to [lemma='mek'] Gene_or_gene_productt+e1: args2Role-mention-ngram: constitutivelytLe2: trigger-arg-path: complex:Binding >nn [lemma='mek'] Gene_or_gene_productt1interceding-token ngrams: mitogenic stimulation ,t4e1: args2Role-mention-ngram: constitutively binds totOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mek'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mek'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mek'] themet5e2: trigger-arg-path: Binding >nn [lemma='mek'] themet9e1: ents2Label-mention-ngram: SHARED constitutively bindstVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ksr'] Gene_or_gene_producttCe2: trigger-arg-path: complex:Binding nn [lemma='mek'] themet%interceding-token ngrams: In responsetUe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='mek'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ksr'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='raf-1'] themetfe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt"interceding-token ngrams: the cellthe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='raf-1'] Gene_or_gene_productt%interceding-token ngrams: MEK complext*interceding-token ngrams: membrane , wheret!e2: ents2Label-mention-ngram: nowt&CSSPATH: ROOT  ++ ROOT >prep_to >rcmodt*interceding-token ngrams: from the cytosolt/e2: ents2Label-mention-ngram: now interact withtNe2: trigger-arg-path: interact >prep_with [lemma='raf-1'] Gene_or_gene_producttBe2: trigger-arg-path: interact:Binding >nsubj theme:Generic_entityt5e2: ents2Label-mention-ngram: interact with activatedtFe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj Generic_entitytinterceding-token ngrams: KSRt>e2: trigger-arg-path: Binding >prep_with [lemma='raf-1'] themet.interceding-token ngrams: complex is recruitedt$e2: args2Role-mention-ngram: can nowt?e2: trigger-arg-path: interact >prep_with [lemma='raf-1'] themet(interceding-token ngrams: cytosol to thet\e2: trigger-arg-path: interact:Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt$interceding-token ngrams: complex istSe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] Generic_entityt!interceding-token ngrams: cytosolt1e2: args2Role-mention-ngram: with activated THEMEtAe2: trigger-arg-path: interact >nsubj [lemma='it'] Generic_entityt"interceding-token ngrams: from thet-e2: args2Role-mention-ngram: can now interacttne2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_producttGe2: trigger-arg-path: interact:Binding >prep_with [lemma='raf-1'] themet e2: args2Role-mention-ngram: nowt,e2: ents2Label-mention-ngram: SHARED can nowt(interceding-token ngrams: recruited fromt(interceding-token ngrams: MEK complex istVe2: trigger-arg-path: interact:Binding >prep_with [lemma='raf-1'] Gene_or_gene_producttnsubj Generic_entityt+interceding-token ngrams: the cell membranetGe2: trigger-arg-path: interact >nsubj [lemma='it'] theme:Generic_entityt'interceding-token ngrams: cell membranet%interceding-token ngrams: the cytosoltJe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] themet*e2: ents2Label-mention-ngram: now interacttLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:Generic_entityt$interceding-token ngrams: cytosol tot*e2: args2Role-mention-ngram: THEME can nowt,e2: ents2Label-mention-ngram: with activatedt+e2: args2Role-mention-ngram: with activatedt,interceding-token ngrams: recruited from thetRe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] themet$interceding-token ngrams: membrane ,t4e2: trigger-arg-path: interact >nsubj Generic_entitytYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='raf-1'] themetinterceding-token ngrams: cellt8e2: trigger-arg-path: interact >nsubj [lemma='it'] themetae2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] theme:Generic_entityt!interceding-token ngrams: KSR andtOe2: trigger-arg-path: interact:Binding >nsubj [lemma='it'] theme:Generic_entitytMe2: trigger-arg-path: Binding >prep_with [lemma='raf-1'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: with activated GENE_OR_GENE_PRODUCTt!interceding-token ngrams: the KSRtSe2: trigger-arg-path: Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt!interceding-token ngrams: , wheret)interceding-token ngrams: cell membrane ,t@e2: trigger-arg-path: interact:Binding >nsubj [lemma='it'] themet`e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='raf-1'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Generic_entityt)interceding-token ngrams: and MEK complext?interceding-tokens-full-span: . In response to mitogenic stimulation , the KSR and MEK complex is recruited from the cytosol to the cell membrane , wheretYe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] theme:Generic_entityt%e2: ents2Label-mention-ngram: can nowt#interceding-token ngrams: recruitedt%interceding-token ngrams: KSR and MEKt"interceding-token ngrams: membranet4e2: args2Role-mention-ngram: interact with activatedt.e2: args2Role-mention-ngram: now interact withtIe2: trigger-arg-path: interact:Binding >nsubj [lemma='it'] Generic_entitytTe2: trigger-arg-path: interact >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt%interceding-token ngrams: to the cellt[e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] Generic_entityt#interceding-token ngrams: , the KSRtNe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Generic_entityt:e2: trigger-arg-path: interact >nsubj theme:Generic_entityt+interceding-token ngrams: is recruited fromt(interceding-token ngrams: the cytosol tot%interceding-token ngrams: the KSR andt&interceding-token ngrams: is recruitedt!interceding-token ngrams: and MEKt)e2: args2Role-mention-ngram: now interactt.e2: ents2Label-mention-ngram: can now interacttNe2: trigger-arg-path: Positive_regulation >nsubj >prep_of Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_producttinterceding-token ngrams: vivotoe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj controller:Gene_or_gene_productt]e1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: can CONTROLLEDtye2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controllert0e1: args2Role-mention-ngram: CONTROLLER also cant{e2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] controllert.interceding-token ngrams: vivo . Co-expressiontBe2: trigger-arg-path: induced >nsubj >prep_of Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of controllertie1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controllertee2: trigger-arg-path: induced >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controllert9e2: ents2Label-mention-ngram: induced mono-ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj Gene_or_gene_producttze2: trigger-arg-path: induced >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also cant3e1: ents2Label-mention-ngram: also can ubiquitinatet^e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED and myc-Mdm2t_e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] Gene_or_gene_productt%e1: args2Role-mention-ngram: also cantPe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj Gene_or_gene_productt8interceding-tokens-full-span: in vivo . Co-expression oft?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controllertBe2: ents2Label-mention-ngram: myc-Mdm2 induced mono-ubiquitinationtFe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj controllertje1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: also cantse1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_producttoe2: trigger-arg-path: induced >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controllert;e2: ents2Label-mention-ngram: mono-ubiquitination of SHAREDt?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controller:Gene_or_gene_productt,interceding-token ngrams: . Co-expression oft1e1: ents2Label-mention-ngram: ubiquitinate SHAREDtqe2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controllert.e2: ents2Label-mention-ngram: myc-Mdm2 inducedtre2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: myc-Mdm2t8e2: trigger-arg-path: induced >nsubj >prep_of controllertnsubj >prep_of Gene_or_gene_productt*e2: ents2Label-mention-ngram: and myc-Mdm2tWe1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controllertae2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttle1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_producttLe2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of controllert!interceding-token ngrams: in vivot5e1: ents2Label-mention-ngram: can ubiquitinate SHAREDtMe1: trigger-arg-path: ubiquitinate >nsubj [lemma='mdm2'] Gene_or_gene_producttIe1: trigger-arg-path: ubiquitinate >nsubj controller:Gene_or_gene_productt>e1: trigger-arg-path: ubiquitinate >nsubj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] Gene_or_gene_producttMe2: trigger-arg-path: induced >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controller:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of Gene_or_gene_productt4e2: args2Role-mention-ngram: CONTROLLER and myc-Mdm2t?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: myc-Mdm2t4e2: ents2Label-mention-ngram: mono-ubiquitination oft_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productte1: outgoing: >prept)interceding-token ngrams: . Co-expressiont,e1: args2Role-mention-ngram: CONTROLLER alsotYe2: trigger-arg-path: Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttCe1: trigger-arg-path: ubiquitinate >nsubj [lemma='mdm2'] controllert4e1: trigger-arg-path: ubiquitinate >nsubj controllert)e2: args2Role-mention-ngram: and myc-Mdm2tXe1: trigger-arg-path: ubiquitinate >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: and myc-Mdm2 inducedt?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='co-expression'] >prep_of [lemma='flag-foxo4'] Gene_or_gene_productt#interceding-token ngrams: in vivo .t-e2: args2Role-mention-ngram: myc-Mdm2 inducedtRe1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj Gene_or_gene_productt2e2: ents2Label-mention-ngram: and myc-Mdm2 inducedt1e2: ents2Label-mention-ngram: mono-ubiquitinationtVe2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_of Gene_or_gene_productte1: trigger: ubiquitinatetHe1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj controllert interceding-token ngrams: vivo .t0e1: args2Role-mention-ngram: also can CONTROLLEDt8e2: args2Role-mention-ngram: myc-Mdm2 induced CONTROLLEDt'interceding-token ngrams: Co-expressiont.e1: ents2Label-mention-ngram: can ubiquitinatetae1: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_productt*interceding-token ngrams: Co-expression oftZe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj controllert*e1: ents2Label-mention-ngram: ubiquitinatetUe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] controllert[e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj controller:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of controllertDe2: trigger-arg-path: Positive_regulation >nsubj >prep_of controllertLe2: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of controllert+e2: ents2Label-mention-ngram: significantlyt?e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of controllert[e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicaltSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicaltfe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltGe1: trigger-arg-path: induced >nsubj [lemma='peroxide'] Simple_chemicaltBe2: trigger-arg-path: reduced >nsubj >prep_of Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert4e2: ents2Label-mention-ngram: reduced SHARED inducedtPe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Simple_chemicaltpe2: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: significantly reducedt@e1: trigger-arg-path: Positive_regulation >nsubj Simple_chemicaltMe2: trigger-arg-path: reduced >nsubj >prep_of controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:Simple_chemicalt[e2: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert/e1: trigger-arg-path: induced >nsubj controllertre2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttge2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert4e1: ents2Label-mention-ngram: mono-ubiquitination oft?e1: trigger-arg-path: induced >nsubj controller:Simple_chemicaltce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] controller:Simple_chemicaltae2: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt@e2: ents2Label-mention-ngram: SHARED induced mono-ubiquitinationtXe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] Simple_chemicaltHe1: trigger-arg-path: induced:Positive_regulation >nsubj Simple_chemicaltVe2: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of Gene_or_gene_producttVe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] controllertKe1: trigger-arg-path: Positive_regulation >nsubj controller:Simple_chemicaltoe2: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllertge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] controllert?shortest-path: nsubj [lemma='knockdown'] >prep_of [lemma='mdm2']twe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicalt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of Gene_or_gene_productt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT significantlytTe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controllert1e1: ents2Label-mention-ngram: mono-ubiquitinationtve2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt0shortest-path: nsubj >prep_oft]trigger-to-trigger-path: e1:induced:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttCe1: trigger-arg-path: induced:Positive_regulation >nsubj controllert@e1: ents2Label-mention-ngram: SHARED induced mono-ubiquitinationtNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] controllertSe1: trigger-arg-path: induced:Positive_regulation >nsubj controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert|e2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of controller:Gene_or_gene_producttntrigger-to-trigger-path: e1:induced:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of controllert?e2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT significantly reducedtle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicalt8e2: trigger-arg-path: reduced >nsubj >prep_of controllertge2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of Gene_or_gene_productt*e2: args2Role-mention-ngram: significantlyt5e2: args2Role-mention-ngram: CONTROLLER significantlytRe1: trigger-arg-path: induced >nsubj [lemma='peroxide'] controller:Simple_chemicalt:e1: args2Role-mention-ngram: CONTROLLER induced CONTROLLEDtBe1: trigger-arg-path: induced >nsubj [lemma='peroxide'] controllert4e1: trigger-arg-path: induced >nsubj Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_producttqe2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt=e2: args2Role-mention-ngram: CONTROLLER significantly reducedtSe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] controllert9e1: ents2Label-mention-ngram: induced mono-ubiquitinationtYe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Simple_chemicaltnsubj Simple_chemicalt/e1: args2Role-mention-ngram: CONTROLLER inducedt:e2: ents2Label-mention-ngram: significantly reduced SHAREDtye2: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: FOXO4 and SHAREDt#e1: ents2Label-mention-ngram: FOXO4t%e1: ents2Label-mention-ngram: of bothtde1: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicaltWe1: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicaltge1: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt(e1: ents2Label-mention-ngram: both FOXO4t?e2: trigger-arg-path: induced >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllertge2: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt9e2: ents2Label-mention-ngram: mono-ubiquitination of botht?e1: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt+e2: ents2Label-mention-ngram: of both FOXO4t?e1: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllert?e2: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllert?e1: trigger-arg-path: induced:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllerte2: CONTROLLER: 4tPe2: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with Simple_chemicalt"e1: ents2Label-mention-ngram: bothtPe1: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt.e1: ents2Label-mention-ngram: FOXO4 and SHAREDt#e2: ents2Label-mention-ngram: FOXO4t?e1: trigger-arg-path: induced:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllertue1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicalt?e2: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicaltKe1: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllertle2: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllert+e1: ents2Label-mention-ngram: of both FOXO4tue2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicaltKe2: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with controllerte1: incoming: csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicaltpe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllert'e2: ents2Label-mention-ngram: FOXO4 andt?e2: trigger-arg-path: induced >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt_e2: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with controllertle1: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicaltWe2: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with controllert?e2: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt%shortest-path: csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt,e1: ents2Label-mention-ngram: both FOXO4 andt[e1: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt9e1: ents2Label-mention-ngram: mono-ubiquitination of botht?e2: trigger-arg-path: induced:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllertoe1: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt,e2: ents2Label-mention-ngram: both FOXO4 andt\e2: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicalt?e2: trigger-arg-path: induced:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt\e1: trigger-arg-path: Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicalt?e1: trigger-arg-path: induced:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicaltoe2: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalte2: incoming: csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicaltae1: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with Simple_chemicalt\e1: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with controllert[e2: trigger-arg-path: induced >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with controller:Simple_chemicaltde2: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with Simple_chemicalt(e2: ents2Label-mention-ngram: both FOXO4t\e2: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with controllertae2: trigger-arg-path: lemmatizedTrigger=induce >csubj >xcomp >prepc_by >prep_with Simple_chemicalt?e1: trigger-arg-path: induced >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controllert'e1: ents2Label-mention-ngram: FOXO4 andt?e1: trigger-arg-path: induced >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt%e2: ents2Label-mention-ngram: of botht?e1: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicaltpe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj >xcomp >prepc_by >prep_with controllert?e1: trigger-arg-path: Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt_e1: trigger-arg-path: induced:Positive_regulation >csubj >xcomp >prepc_by >prep_with controllert?e2: trigger-arg-path: induced >csubj [lemma='report'] >xcomp [lemma='increase'] >prepc_by [lemma='treat'] >prep_with [lemma='peroxide'] Simple_chemicalt3e2: args2Role-mention-ngram: CONTROLLER can mediatetne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] Ubiquitinationt=e2: trigger-arg-path: mediate >dobj controlled:UbiquitinationtXe2: trigger-arg-path: mediate:Positive_regulation >nsubj controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: can mediatet\e2: trigger-arg-path: Positive_regulation >dobj [lemma='mono-ubiquitination'] Ubiquitinationt_e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controllertAe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controllertOe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlled:Ubiquitinationt"interceding-token ngrams: Togethertinterceding-token ngrams: thesetSe2: trigger-arg-path: mediate >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: mediate SHAREDtXe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj UbiquitinationtPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mdm2'] controllertTe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlledtVe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:Gene_or_gene_productt[e2: trigger-arg-path: mediate >dobj [lemma='mono-ubiquitination'] controlled:Ubiquitinationtge2: trigger-arg-path: Positive_regulation >dobj [lemma='mono-ubiquitination'] controlled:Ubiquitinationtde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mdm2'] controllert(e2: args2Role-mention-ngram: can mediatet$interceding-token ngrams: compellingt&interceding-token ngrams: , these datatZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mdm2'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlledtHe2: trigger-arg-path: mediate >nsubj [lemma='mdm2'] Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >dobj controlled:Ubiquitinationt@e2: ents2Label-mention-ngram: mediate SHARED mono-ubiquitinationt'interceding-token ngrams: evidence thattFe2: trigger-arg-path: mediate:Positive_regulation >dobj Ubiquitinationt%e2: ents2Label-mention-ngram: mediatet8e2: ents2Label-mention-ngram: SHARED mono-ubiquitinationtIe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL induced mono-ubiquitinationtde2: trigger-arg-path: mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] Ubiquitinationt.e2: trigger-arg-path: mediate >dobj controlledtBe2: trigger-arg-path: mediate:Positive_regulation >dobj controlledt/e2: args2Role-mention-ngram: mediate CONTROLLEDt!interceding-token ngrams: , thesetye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] controlled:Ubiquitinationt`e2: trigger-arg-path: mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] controlledt2e2: trigger-arg-path: mediate >dobj Ubiquitinationt$interceding-token ngrams: . Togethert>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can mediatetDe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj UbiquitinationtRe2: trigger-arg-path: mediate:Positive_regulation >nsubj [lemma='mdm2'] controllertKe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj Gene_or_gene_productt$interceding-token ngrams: these datat$e2: args2Role-mention-ngram: mediatetMe2: trigger-arg-path: mediate:Positive_regulation >nsubj Gene_or_gene_productt/e2: trigger-arg-path: mediate >nsubj controllert6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT cant*CSSPATH: ROOT >ccomp >ccomp ++ ROOT >ccomptPe2: trigger-arg-path: mediate >dobj [lemma='mono-ubiquitination'] Ubiquitinationte2: trigger: mediatet>e2: trigger-arg-path: Positive_regulation >dobj Ubiquitinationt&interceding-token ngrams: . Together ,toe2: trigger-arg-path: mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] controlled:UbiquitinationtLe2: trigger-arg-path: mediate >dobj [lemma='mono-ubiquitination'] controlledt"interceding-token ngrams: evidencetge2: trigger-arg-path: mediate:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt1interceding-token ngrams: data provide compellingt2interceding-token ngrams: compelling evidence thatt5interceding-token ngrams: provide compelling evidencet-interceding-token ngrams: compelling evidencetDe2: trigger-arg-path: mediate >nsubj controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: can mediate SHAREDt,interceding-token ngrams: these data providetTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_productt$interceding-token ngrams: Together ,t5e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL inducedtre2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='mono-ubiquitination'] controlledtXe2: trigger-arg-path: Positive_regulation >dobj [lemma='mono-ubiquitination'] controlledt\e2: trigger-arg-path: mediate:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_productt*interceding-token ngrams: Together , theset,interceding-token ngrams: provide compellingtCe2: trigger-arg-path: mediate:Positive_regulation >nsubj controllertJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mdm2'] controllertVinterceding-tokens-full-span: . Together , these data provide compelling evidence thatt3e2: args2Role-mention-ngram: can mediate CONTROLLEDt^e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='mono-ubiquitination'] controlledtQe2: trigger-arg-path: mediate:Positive_regulation >dobj controlled:Ubiquitinationtme2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='mono-ubiquitination'] controlled:Ubiquitinationtbe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='mono-ubiquitination'] Ubiquitinationt9e2: trigger-arg-path: mediate >nsubj Gene_or_gene_productt>e2: trigger-arg-path: mediate >nsubj [lemma='mdm2'] controllert&interceding-token ngrams: data providetce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlled:Ubiquitinationtee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt!interceding-token ngrams: providetSe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of controller:Gene_or_gene_productt[e1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert=e1: ents2Label-mention-ngram: reduced SIMPLE_CHEMICAL inducedt:e1: ents2Label-mention-ngram: SHARED significantly reducedt%e1: ents2Label-mention-ngram: reducedt$e1: args2Role-mention-ngram: reducedtee1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_producttye1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt/e1: args2Role-mention-ngram: reduced CONTROLLEDtBe1: trigger-arg-path: reduced >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttae1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt8e1: trigger-arg-path: reduced >nsubj >prep_of controllertMe1: trigger-arg-path: reduced >nsubj >prep_of controller:Gene_or_gene_producttVe1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of Gene_or_gene_producttLe1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of controllert+e1: ents2Label-mention-ngram: significantlytle1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert5e1: ents2Label-mention-ngram: reduced SIMPLE_CHEMICALtoe1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert2e1: ents2Label-mention-ngram: SHARED significantlytge1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllert0e2: ents2Label-mention-ngram: SHARED can mediatetpe1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of controllert2e1: args2Role-mention-ngram: significantly reducedt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controllertre1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of controllert3e1: ents2Label-mention-ngram: significantly reducedte1: trigger: reducedt?e1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt#CSSPATH: ROOT >ccomp ++ ROOT >ccompt5e1: args2Role-mention-ngram: CONTROLLER significantlyt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt*e1: args2Role-mention-ngram: significantlytge1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of Gene_or_gene_productt=e1: args2Role-mention-ngram: significantly reduced CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt=e1: args2Role-mention-ngram: CONTROLLER significantly reducedtCe1: ents2Label-mention-ngram: significantly reduced SIMPLE_CHEMICALt|e1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='mdm2'] Gene_or_gene_productt?e2: ents2Label-mention-ngram: co-immunoprecipitated with SHAREDtZe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='mdm2'] Gene_or_gene_producttUe1: trigger-arg-path: binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttDe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with themetNe1: trigger-arg-path: binding:Binding >prep_between theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='foxo4'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: binding between THEMEt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='foxo4'] themet2e2: args2Role-mention-ngram: co-immunoprecipitatedt>e2: ents2Label-mention-ngram: SHARED was co-immunoprecipitatedtae1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='mdm2'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttNinterceding-tokens-full-span: . Upon co-expression of Flag-Mdm2 and HA-FOXO4 ,tFe1: trigger-arg-path: binding >prep_between theme:Gene_or_gene_productt'interceding-token ngrams: Flag-Mdm2 andt#interceding-token ngrams: Flag-Mdm2tPe1: trigger-arg-path: binding >prep_between [lemma='foxo4'] Gene_or_gene_producttbe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] themetse2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='foxo4'] themetWe1: trigger-arg-path: binding:Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt.interceding-token ngrams: . Upon co-expressiontje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='foxo4'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='foxo4'] Gene_or_gene_productt]e1: trigger-arg-path: binding:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass Gene_or_gene_producttinterceding-token ngrams: Upontnsubjpass themet=e2: trigger-arg-path: Binding >nsubjpass Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] Gene_or_gene_producttSe2: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_productt"e2: trigger: co-immunoprecipitatedtde2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between themetCe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between themet(interceding-token ngrams: and HA-FOXO4 ,t&e2: args2Role-mention-ngram: THEME wastKe2: trigger-arg-path: co-immunoprecipitated >nsubjpass Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_productt>e2: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] themetXe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between theme:Gene_or_gene_producttSe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with Gene_or_gene_productt,e1: args2Role-mention-ngram: binding betweent/interceding-token ngrams: Upon co-expression oftUe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass themetce2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_productt$interceding-token ngrams: HA-FOXO4 ,tCe2: trigger-arg-path: Binding >nsubjpass theme:Gene_or_gene_producttae2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] themetbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='foxo4'] Gene_or_gene_producttAe1: trigger-arg-path: binding >prep_between [lemma='foxo4'] themet'interceding-token ngrams: co-expressiont;e2: args2Role-mention-ngram: was co-immunoprecipitated withtprep_with themetie2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_productt!e2: ents2Label-mention-ngram: wastCSSPATH: ROOT >dobj ++ ROOT t interceding-token ngrams: . Upont*interceding-token ngrams: of Flag-Mdm2 andt&interceding-token ngrams: of Flag-Mdm2t9e1: trigger-arg-path: binding:Binding >prep_between themet3e2: ents2Label-mention-ngram: co-immunoprecipitatedtSe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] themetje2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass theme:Gene_or_gene_productt@e1: trigger-arg-path: binding >prep_between Gene_or_gene_productt4e1: ents2Label-mention-ngram: binding between SHAREDtRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='mdm2'] themet8e2: ents2Label-mention-ngram: co-immunoprecipitated witht=e2: args2Role-mention-ngram: co-immunoprecipitated with THEMEtVe1: trigger-arg-path: Binding >prep_between [lemma='foxo4'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between theme:Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >prep_between [lemma='foxo4'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass themetye2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttYe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass theme:Gene_or_gene_productt.e2: trigger-arg-path: Binding >nsubjpass themetQe2: trigger-arg-path: co-immunoprecipitated >nsubjpass theme:Gene_or_gene_producttLe2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] themet*interceding-token ngrams: co-expression oftAe1: trigger-arg-path: Binding >prep_between [lemma='foxo4'] themethe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='foxo4'] theme:Gene_or_gene_productt@e1: trigger-arg-path: binding >prep_between [lemma='mdm2'] themetUe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with themet-e1: ents2Label-mention-ngram: binding betweentbe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='mdm2'] themet[e2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] Gene_or_gene_producttQe2: trigger-arg-path: co-immunoprecipitated >prep_with theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_between [lemma='foxo4'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttYe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with theme:Gene_or_gene_producttIe1: trigger-arg-path: binding:Binding >prep_between [lemma='foxo4'] themetnsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with theme:Gene_or_gene_producttSe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='foxo4'] themet4interceding-token ngrams: co-expression of Flag-Mdm2tie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='mdm2'] Gene_or_gene_producttDe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass themethe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: SHARED wast\e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] themet7e2: args2Role-mention-ngram: co-immunoprecipitated withtOe1: trigger-arg-path: Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt6e2: args2Role-mention-ngram: was co-immunoprecipitatedt"interceding-token ngrams: HA-FOXO4tZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between Gene_or_gene_producttKe2: trigger-arg-path: co-immunoprecipitated >prep_with Gene_or_gene_producttVe1: trigger-arg-path: binding >prep_between [lemma='foxo4'] theme:Gene_or_gene_productt e2: args2Role-mention-ngram: wastMe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with themetHe1: trigger-arg-path: binding:Binding >prep_between Gene_or_gene_productt,interceding-token ngrams: Upon co-expressiontoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='mdm2'] Gene_or_gene_productt^e1: trigger-arg-path: binding:Binding >prep_between [lemma='foxo4'] theme:Gene_or_gene_productt&interceding-token ngrams: and HA-FOXO4tOe1: trigger-arg-path: binding >prep_between [lemma='mdm2'] Gene_or_gene_productt1e1: trigger-arg-path: binding >prep_between themetze2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_with [lemma='mdm2'] themetprep_with [lemma='mdm2'] theme:Gene_or_gene_producttTe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] themetZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='mdm2'] themet0interceding-token ngrams: Flag-Mdm2 and HA-FOXO4tHe1: trigger-arg-path: binding:Binding >prep_between [lemma='mdm2'] themetUe1: trigger-arg-path: Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: was co-immunoprecipitatedtKe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='mdm2'] themetCe1: trigger-arg-path: Binding >nsubjpass theme:Gene_or_gene_productt(interceding-token ngrams: and vice-versat+e2: ents2Label-mention-ngram: and regulatest.e1: trigger-arg-path: Binding >nsubjpass themet7e1: args2Role-mention-ngram: co-immunoprecipitated witht6e2: trigger-arg-path: binds >dobj Gene_or_gene_productthe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt"e1: trigger: co-immunoprecipitatedt7e2: trigger-arg-path: binds >nsubj [lemma='mdm2'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mdm2'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='foxo4'] themet=e1: trigger-arg-path: Binding >nsubjpass Gene_or_gene_productt1e2: args2Role-mention-ngram: THEME directly bindstqe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt*interceding-token ngrams: , and vice-versat_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='foxo4'] Gene_or_gene_producttQe1: trigger-arg-path: co-immunoprecipitated >prep_with theme:Gene_or_gene_productt"interceding-token ngrams: with ourtLe2: trigger-arg-path: binds >dobj [lemma='foxo4'] theme:Gene_or_gene_productt'interceding-token ngrams: , this resultt>e1: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] themetFe2: trigger-arg-path: binds >dobj [lemma='foxo4'] Gene_or_gene_productt7e2: trigger-arg-path: binds >dobj [lemma='foxo4'] themet8e1: ents2Label-mention-ngram: co-immunoprecipitated withtnsubjpass Gene_or_gene_producttTe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] themetHe2: trigger-arg-path: Binding >dobj [lemma='foxo4'] Gene_or_gene_producttDe2: trigger-arg-path: binds:Binding >dobj theme:Gene_or_gene_productt.interceding-token ngrams: this result suggeststle1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='foxo4'] Gene_or_gene_producttNe2: trigger-arg-path: binds:Binding >nsubj [lemma='mdm2'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: directlyt0e2: args2Role-mention-ngram: binds and regulatest\e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass Gene_or_gene_productt.e2: ents2Label-mention-ngram: regulates SHAREDt7e1: ents2Label-mention-ngram: was co-immunoprecipitatedt&e2: args2Role-mention-ngram: binds andt$interceding-token ngrams: vice-versatLe1: trigger-arg-path: Binding >prep_with [lemma='mdm2'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: binds andt'interceding-token ngrams: in vitro datatTe2: trigger-arg-path: binds:Binding >dobj [lemma='foxo4'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: THEME wastMe1: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_producttie1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass themet'e2: trigger-arg-path: binds >dobj themet'interceding-token ngrams: suggests thatt1interceding-token ngrams: vice-versa . Consistenttbe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] Gene_or_gene_producttSe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >nsubj [lemma='mdm2'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binds >nsubj [lemma='mdm2'] theme:Gene_or_gene_producttae1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttZe1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='mdm2'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] themetce1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_productt*interceding-token ngrams: and vice-versa .t2e1: args2Role-mention-ngram: co-immunoprecipitatedt3e2: ents2Label-mention-ngram: SHARED directly bindst,e2: ents2Label-mention-ngram: directly bindstYe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass theme:Gene_or_gene_productt&interceding-token ngrams: our in vitrot`e1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt interceding-token ngrams: resulttte1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] Gene_or_gene_productt+e2: args2Role-mention-ngram: directly bindst&interceding-token ngrams: . Consistenttninterceding-tokens-full-span: , and vice-versa . Consistent with our in vitro data , this result suggests thatt3e1: ents2Label-mention-ngram: co-immunoprecipitatedt interceding-token ngrams: our int]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='foxo4'] theme:Gene_or_gene_producttnsubjpass themetze1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass themetWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='foxo4'] Gene_or_gene_productt"interceding-token ngrams: suggeststSe1: trigger-arg-path: Binding >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_productt/e2: trigger-arg-path: binds:Binding >dobj themet2e2: ents2Label-mention-ngram: and regulates SHAREDt&interceding-token ngrams: vice-versa .tDe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass themet'e2: ents2Label-mention-ngram: regulatest0e2: args2Role-mention-ngram: and regulates THEMEt-interceding-token ngrams: Consistent with ourtUe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with themetYe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='mdm2'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: directly binds andt$interceding-token ngrams: vitro datat]e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='foxo4'] themetbe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: was co-immunoprecipitatedtNe2: trigger-arg-path: binds:Binding >dobj [lemma='foxo4'] Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding >dobj Gene_or_gene_productt%interceding-token ngrams: data , thist$interceding-token ngrams: Consistentt?e2: trigger-arg-path: binds:Binding >nsubj [lemma='mdm2'] themet?e1: ents2Label-mention-ngram: co-immunoprecipitated with SHAREDt9e2: trigger-arg-path: Binding >nsubj [lemma='mdm2'] themet=e1: args2Role-mention-ngram: co-immunoprecipitated with THEMEt/e2: args2Role-mention-ngram: directly binds andtFe2: trigger-arg-path: binds >nsubj [lemma='mdm2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mdm2'] Gene_or_gene_productt)interceding-token ngrams: result suggestst;e1: args2Role-mention-ngram: was co-immunoprecipitated witht9e2: trigger-arg-path: Binding >dobj [lemma='foxo4'] themet-CSSPATH: ROOT  ++ ROOT >prep_with >dep >ccomptde1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mdm2'] theme:Gene_or_gene_productt%interceding-token ngrams: this resulttbe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='mdm2'] themet&interceding-token ngrams: vitro data ,t e1: args2Role-mention-ngram: wastKe1: trigger-arg-path: co-immunoprecipitated >prep_with Gene_or_gene_productt&e2: args2Role-mention-ngram: regulatestMe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with themet,e2: args2Role-mention-ngram: regulates THEMEtje1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass theme:Gene_or_gene_productt[e1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with Gene_or_gene_producttHe2: trigger-arg-path: Binding >nsubj [lemma='mdm2'] Gene_or_gene_producttinterceding-token ngrams: ourt.interceding-token ngrams: result suggests thattPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mdm2'] themet-e2: ents2Label-mention-ngram: SHARED directlytDe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with themetLe1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='foxo4'] themetee1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='foxo4'] themetSe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with Gene_or_gene_productt1e2: ents2Label-mention-ngram: binds and regulatest>e1: ents2Label-mention-ngram: SHARED was co-immunoprecipitatedt?e2: trigger-arg-path: binds:Binding >dobj [lemma='foxo4'] themetKe1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='mdm2'] themet\e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] themet interceding-token ngrams: data ,tPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='foxo4'] themetje1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: and regulatestke1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='mdm2'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='foxo4'] theme:Gene_or_gene_producttprep_with themet+interceding-token ngrams: . Consistent withtee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='foxo4'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >dobj [lemma='foxo4'] theme:Gene_or_gene_producttQe1: trigger-arg-path: co-immunoprecipitated >nsubjpass theme:Gene_or_gene_producttnsubj [lemma='mdm2'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: directlytSe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='mdm2'] themetHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mdm2'] themet)interceding-token ngrams: Consistent witht%interceding-token ngrams: with our intNe2: trigger-arg-path: Binding >nsubj [lemma='mdm2'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: THEME directlytdobj theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by Gene_or_gene_producttze1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Gene_or_gene_productt5e2: args2Role-mention-ngram: CONTROLLED by CONTROLLERt$interceding-token ngrams: Regulationthe2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation >prep_by [lemma='mdm2'] controller:Gene_or_gene_producttNe1: trigger-arg-path: Negative_regulation >nsubj >prep_of Gene_or_gene_producttpe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controllert9e1: trigger-arg-path: inhibits >nsubj >prep_of controllertYe1: trigger-arg-path: Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: induced byt_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: ubiquitination bytqe1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Gene_or_gene_producttGe2: trigger-arg-path: ubiquitination >prep_by [lemma='mdm2'] controllertVe2: trigger-arg-path: Positive_regulation >prep_by [lemma='mdm2'] Gene_or_gene_productt\e2: trigger-arg-path: ubiquitination >prep_by [lemma='mdm2'] controller:Gene_or_gene_productt=e1: ents2Label-mention-ngram: inhibits mono-ubiquitination oftJe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of controllert[e2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] controllert-interceding-tokens-full-span: . Regulation oftwe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Gene_or_gene_producttfe1: trigger-arg-path: inhibits >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by controllertMe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of controllertMe2: trigger-arg-path: ubiquitination >prep_by controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: by SHAREDt\e1: trigger-arg-path: inhibits >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controllert6e2: ents2Label-mention-ngram: ubiquitination by SHAREDtTe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of Gene_or_gene_producttBe2: trigger-arg-path: ubiquitination >prep_by Gene_or_gene_productt*e2: args2Role-mention-ngram: by CONTROLLERtWe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt8e1: ents2Label-mention-ngram: induced by SIMPLE_CHEMICALtne2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by [lemma='mdm2'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED ubiquitinationt8e2: trigger-arg-path: ubiquitination >prep_by controllert,e2: ents2Label-mention-ngram: ubiquitinationtwe2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by controller:Gene_or_gene_producttae2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: of SHARED inducedtVe2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by Gene_or_gene_productt,CSSPATH: ROOT >ccomp ++ ROOT >nsubj >prep_oft)interceding-token ngrams: . Regulation oft:e1: ents2Label-mention-ngram: inhibits mono-ubiquitinationtYe2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by [lemma='mdm2'] controllert=e2: trigger-arg-path: Positive_regulation >prep_by controllertAe1: ents2Label-mention-ngram: SHARED inhibits mono-ubiquitinationtpe2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=ubiquitination >prep_by [lemma='mdm2'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: SHARED ubiquitination bytqe1: trigger-arg-path: inhibits >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_producttee2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] controller:Gene_or_gene_productt'interceding-token ngrams: Regulation oft/e1: ents2Label-mention-ngram: SHARED induced byt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controllertRe2: trigger-arg-path: Positive_regulation >prep_by controller:Gene_or_gene_producttCe1: trigger-arg-path: inhibits >nsubj >prep_of Gene_or_gene_producttbe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttLe2: trigger-arg-path: ubiquitination:Positive_regulation >prep_by controllertme2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by [lemma='mdm2'] controllertNe1: trigger-arg-path: inhibits >nsubj >prep_of controller:Gene_or_gene_producttge1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controllertQe2: trigger-arg-path: ubiquitination >prep_by [lemma='mdm2'] Gene_or_gene_producttGe2: trigger-arg-path: Positive_regulation >prep_by Gene_or_gene_productte2: trigger: ubiquitinationtLe2: trigger-arg-path: Positive_regulation >prep_by [lemma='mdm2'] controllertme1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controllert|e1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED inhibitstDe1: trigger-arg-path: Negative_regulation >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt;e1: args2Role-mention-ngram: CONTROLLER inhibits CONTROLLEDt0e1: ents2Label-mention-ngram: by SIMPLE_CHEMICALt^e2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation >prep_by controllert^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of controllert?e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt&interceding-token ngrams: . RegulationtMe1: trigger-arg-path: induced nsubj >prep_of controlledtTe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controllert?e1: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationtae1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlledt'e1: args2Role-mention-ngram: induced bytre1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlled:Negative_regulationtGe1: trigger-arg-path: induced >agent [lemma='peroxide'] Simple_chemicaltACSSPATH: ROOT >ccomp >dobj >prep_of >vmod ++ ROOT >nsubj >prep_oftRe1: trigger-arg-path: induced >agent [lemma='peroxide'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationtVe1: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] controllertPe1: trigger-arg-path: lemmatizedTrigger=induce >agent controller:Simple_chemicalt4e1: trigger-arg-path: induced >agent Simple_chemicalt^e1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlledtge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] controllertde1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controller:Simple_chemicaltbe1: trigger-arg-path: Positive_regulation nsubj >prep_of Negative_regulationtYe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationtEe1: trigger-arg-path: lemmatizedTrigger=induce >agent Simple_chemicalt?e1: trigger-arg-path: induced >agent controller:Simple_chemicalt[e1: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] Simple_chemicaltYe1: trigger-arg-path: Positive_regulation nsubj >prep_of controlledtSe1: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] Simple_chemicalte1: CONTROLLED: 5tme1: trigger-arg-path: Positive_regulation nsubj >prep_of controlled:Negative_regulationtKe1: trigger-arg-path: Positive_regulation >agent controller:Simple_chemicaltNe1: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] controllertre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlledtge1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of Negative_regulationtfe1: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicalt@e1: trigger-arg-path: Positive_regulation >agent Simple_chemicaltue1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlled:Negative_regulationtVe1: trigger-arg-path: induced nsubj >prep_of Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtXe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledt^e1: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicaltHe1: trigger-arg-path: induced:Positive_regulation >agent Simple_chemicalt@e1: trigger-arg-path: lemmatizedTrigger=induce >agent controllert?e1: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationt{e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of Negative_regulationtce1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] controller:Simple_chemicaltBe1: trigger-arg-path: induced >agent [lemma='peroxide'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtSe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] controllertSe1: trigger-arg-path: induced:Positive_regulation >agent controller:Simple_chemicalt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicalt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtje1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of Negative_regulationt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlled:Negative_regulationt?e1: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtae1: trigger-arg-path: induced nsubj >prep_of controlled:Negative_regulationt/e1: trigger-arg-path: induced >agent controllert/e1: args2Role-mention-ngram: CONTROLLED inducedtle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] Simple_chemicalt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledt?e1: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtCe1: trigger-arg-path: induced:Positive_regulation >agent controllert2e1: args2Role-mention-ngram: CONTROLLED induced byt2e1: args2Role-mention-ngram: induced by CONTROLLERt$interceding-token ngrams: inhibitorythe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] themet3e2: trigger-arg-path: Binding >conj_and >dobj themet`e2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='target'] >dobj [lemma='rb'] themetWe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with theme:Gene_or_gene_producttYe1: trigger-arg-path: associates:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='ink4b'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj themet3interceding-token ngrams: their inhibitory activitytNe2: trigger-arg-path: binds:Binding >nsubj [lemma='tax1'] Gene_or_gene_producttinterceding-token ngrams: -t0interceding-token ngrams: inhibitory activity oftinterceding-token ngrams: ]t1e1: trigger-arg-path: associates >prep_with themetinterceding-token ngrams: INK4atNe1: trigger-arg-path: associates:Binding >prep_with theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: also associatestCSSPATH: ROOT  ++ ROOT t\e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='tax1'] Gene_or_gene_producttPe1: trigger-arg-path: associates >prep_with [lemma='ink4b'] Gene_or_gene_producttle2: trigger-arg-path: binds:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] theme:Gene_or_gene_productt%interceding-token ngrams: counteractstde1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='tax1'] Gene_or_gene_productt-interceding-token ngrams: inhibitory activityt/interceding-token ngrams: INK4a and counteractst>e1: trigger-arg-path: Binding >prep_with [lemma='ink4b'] themet9e2: trigger-arg-path: binds:Binding >conj_and >dobj themetBe2: trigger-arg-path: Binding >conj_and >dobj Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tax1'] themetSe1: trigger-arg-path: associates:Binding >nsubj [lemma='tax1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tax1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: associates:Binding >prep_with [lemma='ink4b'] themetNe2: trigger-arg-path: binds:Binding >conj_and >dobj theme:Gene_or_gene_producttinterceding-token ngrams: - ]tWe2: trigger-arg-path: binds:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] themet#interceding-token ngrams: p16 INK4at,e1: args2Role-mention-ngram: associates withtBe1: trigger-arg-path: associates >nsubj theme:Gene_or_gene_productt*interceding-token ngrams: activity of CDK4tMe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj Gene_or_gene_producttnsubj [lemma='tax1'] themetfe2: trigger-arg-path: Binding >conj_and [lemma='target'] >dobj [lemma='rb'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: and targetst!interceding-token ngrams: of CDK4t%e2: ents2Label-mention-ngram: targetst-e1: trigger-arg-path: associates >nsubj themetinterceding-token ngrams: - ] .tQe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='target'] >dobj [lemma='rb'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: targets THEMEt(e2: args2Role-mention-ngram: and targetst"interceding-token ngrams: CDK4 [ -tHe2: trigger-arg-path: binds:Binding >conj_and >dobj Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED also associatestUe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj Gene_or_gene_productt6interceding-token ngrams: counteracts their inhibitoryt#interceding-token ngrams: of CDK4 [tHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tax1'] themetNe2: trigger-arg-path: Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt+interceding-token ngrams: counteracts theirt%e1: args2Role-mention-ngram: with p15t&e1: args2Role-mention-ngram: p15 THEMEt e1: args2Role-mention-ngram: p15t-e1: ents2Label-mention-ngram: also associatest7e2: trigger-arg-path: binds >nsubj [lemma='tax1'] themetinterceding-token ngrams: p16tee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt*interceding-token ngrams: their inhibitoryt&e1: ents2Label-mention-ngram: with p15t$e2: ents2Label-mention-ngram: to andt5e1: trigger-arg-path: associates:Binding >nsubj themetBe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj themet:e2: ents2Label-mention-ngram: targets GENE_OR_GENE_PRODUCTt!interceding-token ngrams: and p16tinterceding-token ngrams: theirtDe1: trigger-arg-path: associates:Binding >nsubj Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_with [lemma='ink4b'] theme:Gene_or_gene_productte1: trigger: associatest;e1: ents2Label-mention-ngram: with p15 GENE_OR_GENE_PRODUCTt+e1: args2Role-mention-ngram: with p15 THEMEt^e2: trigger-arg-path: binds >conj_and [lemma='target'] >dobj [lemma='rb'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with themet-e1: ents2Label-mention-ngram: associates witht_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tax1'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='ink4b'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with theme:Gene_or_gene_productt9e1: trigger-arg-path: associates:Binding >prep_with themetFe2: trigger-arg-path: binds >nsubj [lemma='tax1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: binds to andtAe1: trigger-arg-path: associates >prep_with [lemma='ink4b'] themetHe2: trigger-arg-path: Binding >nsubj [lemma='tax1'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: also associates witht}e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] theme:Gene_or_gene_producttXe1: trigger-arg-path: associates:Binding >prep_with [lemma='ink4b'] Gene_or_gene_productt interceding-token ngrams: CDK4 [t%interceding-token ngrams: activity oftFe1: trigger-arg-path: associates >prep_with theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt>e2: ents2Label-mention-ngram: and targets GENE_OR_GENE_PRODUCTtYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with Gene_or_gene_productt'interceding-token ngrams: and p16 INK4atinterceding-token ngrams: ] .t!interceding-token ngrams: FinallytRe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='ink4b'] themetZe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='ink4b'] themet[e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: THEME also associatestUe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='tax1'] themet1e1: ents2Label-mention-ngram: associates with p15tinterceding-token ngrams: [tFe2: trigger-arg-path: binds >conj_and >dobj theme:Gene_or_gene_productt$e2: args2Role-mention-ngram: targetstoe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='target'] >dobj [lemma='rb'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj theme:Gene_or_gene_productt#interceding-token ngrams: Finally ,tHe1: trigger-arg-path: associates:Binding >prep_with Gene_or_gene_productt%interceding-token ngrams: ] . Finallyt@e2: trigger-arg-path: binds >conj_and >dobj Gene_or_gene_producttnsubj Gene_or_gene_producttQe1: trigger-arg-path: associates >nsubj [lemma='tax1'] theme:Gene_or_gene_productt#interceding-token ngrams: INK4a andtJe1: trigger-arg-path: associates:Binding >nsubj theme:Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >nsubj [lemma='tax1'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: to andtHe2: trigger-arg-path: Binding >conj_and >dobj theme:Gene_or_gene_productt'interceding-token ngrams: p16 INK4a andtMe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='tax1'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tax1'] Gene_or_gene_productt)interceding-token ngrams: and counteractst,e2: ents2Label-mention-ngram: to and targetstae1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='ink4b'] Gene_or_gene_producttinterceding-token ngrams: [ -t`e2: trigger-arg-path: Binding >conj_and [lemma='target'] >dobj [lemma='rb'] Gene_or_gene_productt'e1: args2Role-mention-ngram: associatestLe2: trigger-arg-path: binds >nsubj [lemma='tax1'] theme:Gene_or_gene_productt%interceding-token ngrams: . Finally ,t+e2: args2Role-mention-ngram: to and targetstie1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='ink4b'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: p15tKe1: trigger-arg-path: associates >nsubj [lemma='tax1'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: associatestinterceding-token ngrams: CDK4t^e1: trigger-arg-path: associates:Binding >prep_with [lemma='ink4b'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj theme:Gene_or_gene_producttOe2: trigger-arg-path: binds >conj_and [lemma='target'] >dobj [lemma='rb'] themetMe1: trigger-arg-path: Binding >prep_with [lemma='ink4b'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj Gene_or_gene_productt6e1: ents2Label-mention-ngram: p15 GENE_OR_GENE_PRODUCTtbe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='tax1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj Gene_or_gene_productt/interceding-token ngrams: and counteracts theirtwe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] Gene_or_gene_productt@e1: trigger-arg-path: associates >prep_with Gene_or_gene_producttQe2: trigger-arg-path: Binding >conj_and [lemma='target'] >dobj [lemma='rb'] themetSe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj theme:Gene_or_gene_producttVe1: trigger-arg-path: associates >prep_with [lemma='ink4b'] theme:Gene_or_gene_productt1e2: trigger-arg-path: binds >conj_and >dobj themet"interceding-token ngrams: activityt)e1: ents2Label-mention-ngram: SHARED alsotde2: trigger-arg-path: binds >conj_and [lemma='target'] >dobj [lemma='rb'] theme:Gene_or_gene_productt#interceding-token ngrams: . Finallyt)e2: args2Role-mention-ngram: binds to andtFe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj themet1e1: args2Role-mention-ngram: also associates witht.e2: args2Role-mention-ngram: and targets THEMEtBe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with themetDe1: trigger-arg-path: associates:Binding >nsubj [lemma='tax1'] themet0e1: args2Role-mention-ngram: associates with p15tinterceding-token ngrams: [ - ]t?e2: trigger-arg-path: binds:Binding >nsubj [lemma='tax1'] themetointerceding-tokens-full-span: and p16 INK4a and counteracts their inhibitory activity of CDK4 [ - ] . Finally ,te2: outgoing: >preptfe2: trigger-arg-path: binds:Binding >conj_and [lemma='target'] >dobj [lemma='rb'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='tax1'] themet>e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj themetOinterceding-tokens-full-span: has not yet been identified , a study showed thattNe1: trigger-arg-path: Positive_regulation >agent [lemma='ikkalpha'] controllert-interceding-token ngrams: yet been identifiedtZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='ikkalpha'] controller:Gene_or_gene_producttXe1: trigger-arg-path: Positive_regulation agent [lemma='ikkalpha'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='ikkalpha'] Gene_or_gene_producttce1: trigger-arg-path: Positive_regulation >agent [lemma='ikkalpha'] controller:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylated:Positive_regulation nsubj [lemma='ikkalpha'] controllertme1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='ikkalpha'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] Gene_or_gene_producttIe1: trigger-arg-path: phosphorylated >agent [lemma='ikkalpha'] controllertSe1: trigger-arg-path: phosphorylated nsubj [lemma='ikkalpha'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation ccomp [lemma='phosphorylate'] >nsubj [lemma='ikkalpha'] >amod [lemma='nuclear']tNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] controllert6e1: ents2Label-mention-ngram: SHARED phosphorylated bytSe1: trigger-arg-path: phosphorylated >agent [lemma='ikkalpha'] Gene_or_gene_producttge1: trigger-arg-path: phosphorylated:Positive_regulation nsubj [lemma='ikkalpha'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='ikkalpha'] controllert(interceding-token ngrams: a study showedt!interceding-token ngrams: a studyt?trigger-to-trigger-path: e1:phosphorylated:Positive_regulation ccomp [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationtZe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] controllertoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ikkalpha'] controller:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='ikkalpha'] controllertIe1: trigger-arg-path: phosphorylated:Positive_regulation nsubj [lemma='ikkalpha'] Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylated:Positive_regulation ccomp e2:phosphorylates:Positive_regulationt#interceding-token ngrams: , a studyt5e1: trigger-arg-path: phosphorylated agent [lemma='ikkalpha'] Gene_or_gene_productt=shortest-path: ccomp >nsubj >amodtce2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='ikkalpha'] Gene_or_gene_productt]e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ikkalpha'] controllertoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikkalpha'] controller:Gene_or_gene_producttXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikkalpha'] Gene_or_gene_productt"interceding-token ngrams: yet beentinterceding-token ngrams: beentxe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikkalpha'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_regulation nsubj [lemma='ikkalpha'] controllertEe1: trigger-arg-path: phosphorylated agent [lemma='ikkalpha'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ikkalpha'] controllertde1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ikkalpha'] Gene_or_gene_productt\e1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3beta'] theme:Gene_or_gene_productt$e2: ents2Label-mention-ngram: Ser410tQe2: trigger-arg-path: phosphorylate nsubj controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: DNMT1tle2: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='dnmt1'] theme:Gene_or_gene_producttFe2: trigger-arg-path: phosphorylate nsubj Gene_or_gene_productt+e2: ents2Label-mention-ngram: at Ser410 andt#e2: ents2Label-mention-ngram: DNMT1tXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3beta'] themetve2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controllert+e2: ents2Label-mention-ngram: phosphorylatet0e2: args2Role-mention-ngram: DNMT1 to CONTROLLEDt@e1: trigger-arg-path: interacts >prep_with [lemma='dnmt1'] themet1e2: args2Role-mention-ngram: interacts with DNMT1tbe2: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] controllertee2: trigger-arg-path: phosphorylate:Positive_regulation nsubj controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: interacts with DNMT1tOe1: trigger-arg-path: interacts >prep_with [lemma='dnmt1'] Gene_or_gene_productt}e2: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controllert.e2: ents2Label-mention-ngram: to phosphorylatetYtrigger-to-trigger-path: e1:interacts:Binding >xcomp e2:phosphorylate:Positive_regulationtUe1: trigger-arg-path: interacts >prep_with [lemma='dnmt1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='dnmt1'] themet*e2: args2Role-mention-ngram: with DNMT1 tot+e2: args2Role-mention-ngram: interacts withtwe2: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: to phosphorylate SHAREDtTe1: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: to CONTROLLEDt_e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] Gene_or_gene_productt]e1: trigger-arg-path: interacts:Binding >prep_with [lemma='dnmt1'] theme:Gene_or_gene_producttHe1: trigger-arg-path: interacts:Binding >prep_with [lemma='dnmt1'] themet?e2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_productte2: trigger: phosphorylatet2e2: ents2Label-mention-ngram: phosphorylate SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER interactstre2: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj controllertRe1: trigger-arg-path: Binding >nsubj [lemma='gsk3beta'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Positive_regulation nsubj Gene_or_gene_productt(e2: ents2Label-mention-ngram: with DNMT1t.e2: ents2Label-mention-ngram: SHARED at Ser410the1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='dnmt1'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: Ser410 andt?e1: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] themet`e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='dnmt1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controllert%e2: args2Role-mention-ngram: DNMT1 totne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='dnmt1'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: and Ser414t?e2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj Gene_or_gene_productt'e2: args2Role-mention-ngram: with DNMT1t5e2: ents2Label-mention-ngram: phosphorylate SHARED att'e2: ents2Label-mention-ngram: at Ser410tBe2: trigger-arg-path: Positive_regulation nsubj controllertWe1: trigger-arg-path: interacts:Binding >prep_with [lemma='dnmt1'] Gene_or_gene_producttVe1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3beta'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: with DNMT1 totLe1: trigger-arg-path: Binding >nsubj [lemma='gsk3beta'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] controllert$e2: ents2Label-mention-ngram: Ser414tWe2: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='dnmt1'] themethe2: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_productt&e2: args2Role-mention-ngram: interactstme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3beta'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: DNMT1 totXe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj Gene_or_gene_producttGe1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3beta'] themet/e2: ents2Label-mention-ngram: Ser410 and Ser414tNe1: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] Gene_or_gene_producttqtrigger-to-trigger-path: e1:interacts:Binding >xcomp [lemma='phosphorylate'] e2:phosphorylate:Positive_regulationtPe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] themetMe1: trigger-arg-path: Binding >prep_with [lemma='dnmt1'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_with [lemma='dnmt1'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3beta'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: DNMT1 to phosphorylatet>e1: trigger-arg-path: Binding >prep_with [lemma='dnmt1'] themetnsubj controllertce2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controller:Gene_or_gene_producttZe2: trigger-arg-path: phosphorylate:Positive_regulation nsubj Gene_or_gene_producttPe2: trigger-arg-path: phosphorylate:Positive_regulation nsubj controllert~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] Gene_or_gene_productt6e2: args2Role-mention-ngram: CONTROLLER interacts withtwe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj controller:Gene_or_gene_productt=e1: trigger-arg-path: Binding >nsubj [lemma='gsk3beta'] themet+e2: args2Role-mention-ngram: NRG4 bind onlyt?e2: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] themet-e2: ents2Label-mention-ngram: SHARED and NRG4t9e1: trigger-arg-path: Binding >nsubj [lemma='nrg3'] themet:e2: trigger-arg-path: Binding >dobj [lemma='erbb-4'] themetHe1: trigger-arg-path: Binding >nsubj [lemma='nrg3'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: NRG4 bind onlyt.e1: ents2Label-mention-ngram: bind only SHAREDt>e2: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] themet"e2: ents2Label-mention-ngram: NRG4tQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] themetNe2: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] Gene_or_gene_producttDe2: trigger-arg-path: bind:Binding >nsubj theme:Gene_or_gene_producttLe1: trigger-arg-path: bind >dobj [lemma='erbb-4'] theme:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: onlytFe1: trigger-arg-path: bind >dobj [lemma='erbb-4'] Gene_or_gene_productt'e1: args2Role-mention-ngram: only THEMEt%e2: args2Role-mention-ngram: and NRG4t+e2: args2Role-mention-ngram: THEME and NRG4t6e2: trigger-arg-path: bind >nsubj [lemma='nrg3'] themetMe1: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >dobj [lemma='erbb-4'] Gene_or_gene_producttnsubj theme:Gene_or_gene_productt>e2: trigger-arg-path: bind:Binding >nsubj Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='nrg3'] themetSe2: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: and NRG4 bindtKe1: trigger-arg-path: bind >nsubj [lemma='nrg3'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: and NRG4tEe1: trigger-arg-path: bind >nsubj [lemma='nrg3'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: NRG4 bind onlyt-e1: ents2Label-mention-ngram: SHARED and NRG4tNe2: trigger-arg-path: Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_producttMe2: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] Gene_or_gene_producttKe2: trigger-arg-path: bind >nsubj [lemma='nrg3'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] Gene_or_gene_productt6e2: trigger-arg-path: bind >nsubj Gene_or_gene_productt&e2: ents2Label-mention-ngram: and NRG4tWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: and NRG4tXe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: NRG4 bindt&e1: args2Role-mention-ngram: bind onlyt&e2: args2Role-mention-ngram: bind onlyt+e1: args2Role-mention-ngram: THEME and NRG4tPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] themet!e1: args2Role-mention-ngram: NRG4t'e2: ents2Label-mention-ngram: bind onlytHe2: trigger-arg-path: Binding >nsubj [lemma='nrg3'] Gene_or_gene_productt,e1: args2Role-mention-ngram: bind only THEMEt:e1: trigger-arg-path: Binding >dobj [lemma='erbb-4'] themet!e1: args2Role-mention-ngram: onlytIe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] themet.e2: ents2Label-mention-ngram: bind only SHAREDtFe2: trigger-arg-path: bind >dobj [lemma='erbb-4'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] themet&e2: args2Role-mention-ngram: NRG4 bindt'e2: args2Role-mention-ngram: only THEMEt&e1: args2Role-mention-ngram: NRG4 bindt,e1: ents2Label-mention-ngram: NRG4 bind onlyt)e2: ents2Label-mention-ngram: only SHAREDt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] Gene_or_gene_productt*e1: args2Role-mention-ngram: and NRG4 bindt,e2: args2Role-mention-ngram: bind only THEMEt7e2: trigger-arg-path: bind >dobj [lemma='erbb-4'] themetIe1: trigger-arg-path: Binding >dobj [lemma='erbb-4'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_producttTe1: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_producttTe2: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_producttLe2: trigger-arg-path: bind >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] Gene_or_gene_producttSe1: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: and NRG4 bindt'e1: ents2Label-mention-ngram: NRG4 bindt?e1: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] themet'e1: ents2Label-mention-ngram: bind onlyt!e2: args2Role-mention-ngram: NRG4tOe2: trigger-arg-path: Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt>e1: trigger-arg-path: bind:Binding >nsubj [lemma='nrg3'] themet"e1: ents2Label-mention-ngram: NRG4tEe2: trigger-arg-path: bind >nsubj [lemma='nrg3'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] Gene_or_gene_producttNe1: trigger-arg-path: bind:Binding >dobj [lemma='erbb-4'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrg3'] theme:Gene_or_gene_productt7e1: trigger-arg-path: bind >dobj [lemma='erbb-4'] themet)e1: ents2Label-mention-ngram: only SHAREDtfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='erbb-4'] theme:Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj [lemma='nrg3'] themet+e2: ents2Label-mention-ngram: and NRG4 bindt|shortest-path: dobj [lemma='acetylation'] >appos [lemma='recruitment']tHe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT significantly reducedt:e2: trigger-arg-path: Binding >prep_of [lemma='p53'] themet)e2: ents2Label-mention-ngram: recruitmentt\e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p300'] theme:Gene_or_gene_producttpe1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controllertKe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj controlled:Acetylationt\e1: trigger-arg-path: Negative_regulation >dobj [lemma='acetylation'] controlled:Acetylationt$interceding-token ngrams: , impairedt?e2: trigger-arg-path: recruitment >prep_of Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p53'] theme:Gene_or_gene_producttUe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p53'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj controlled:Acetylationt?e1: trigger-arg-path: lemmatizedTrigger=reduce >dobj controlledt)e2: args2Role-mention-ngram: of THEME andt;e1: trigger-arg-path: Negative_regulation >dobj Acetylationt/e1: trigger-arg-path: reduced >dobj AcetylationtYe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p300'] themetae1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='acetylation'] controlled:AcetylationtTe2: trigger-arg-path: recruitment >prep_of [lemma='p300'] theme:Gene_or_gene_productt>e2: trigger-arg-path: recruitment >prep_of [lemma='p53'] themetne2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p300'] theme:Gene_or_gene_producttSe2: trigger-arg-path: recruitment >prep_of [lemma='p53'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controllert"interceding-token ngrams: impairedtje1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='acetylation'] AcetylationtUe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='acetylation'] controlledt8e2: trigger-arg-path: recruitment:Binding >prep_of themetPe2: trigger-arg-path: Binding >prep_of [lemma='p300'] theme:Gene_or_gene_productt+shortest-path: dobj >appost(e2: args2Role-mention-ngram: recruitmenttue1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='acetylation'] controlled:Acetylationt+e2: args2Role-mention-ngram: recruitment oft?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] Gene_or_gene_producttDe1: trigger-arg-path: reduced >dobj [lemma='acetylation'] controlledtEe2: trigger-arg-path: recruitment >prep_of theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p53'] theme:Gene_or_gene_producttXe1: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='acetylation'] controlledt?e2: trigger-arg-path: recruitment >prep_of [lemma='p300'] themetWe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of theme:Gene_or_gene_producttde1: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='acetylation'] controlled:Acetylationt0e1: ents2Label-mention-ngram: SHARED acetylationt,e2: ents2Label-mention-ngram: recruitment oftJe2: trigger-arg-path: Binding >prep_of [lemma='p300'] Gene_or_gene_productt?e1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controller:Gene_or_gene_producttqe1: trigger-arg-path: reduced >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controller:Gene_or_gene_producttPe1: trigger-arg-path: reduced >dobj [lemma='acetylation'] controlled:AcetylationtPe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p53'] themet)e1: ents2Label-mention-ngram: acetylationt,e1: ents2Label-mention-ngram: reduced SHAREDt8e1: ents2Label-mention-ngram: reduced SHARED acetylationtMe2: trigger-arg-path: recruitment >prep_of [lemma='p53'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: recruitment of SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controller:Gene_or_gene_productt}e1: trigger-arg-path: Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controller:Gene_or_gene_producttze1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] Gene_or_gene_producttCe1: trigger-arg-path: reduced:Negative_regulation >dobj AcetylationtXe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p53'] themetLe1: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of controllerthe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p300'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: significantly reduced SHAREDtVe1: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of themetge2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='p53'] Gene_or_gene_productt[e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p53'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: recruitment of THEMEtEe1: trigger-arg-path: reduced >dobj [lemma='acetylation'] Acetylationtfe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p300'] theme:Gene_or_gene_producttGe2: trigger-arg-path: recruitment:Binding >prep_of Gene_or_gene_producttQe1: trigger-arg-path: Negative_regulation >dobj [lemma='acetylation'] Acetylationt(interceding-tokens-full-span: , impairedt@e1: trigger-arg-path: lemmatizedTrigger=reduce >dobj AcetylationtSe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj controlledtOe2: trigger-arg-path: Binding >prep_of [lemma='p53'] theme:Gene_or_gene_productt\e1: trigger-arg-path: reduced >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controllert`e2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p300'] Gene_or_gene_producttfe1: trigger-arg-path: reduced >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] Gene_or_gene_productt[trigger-to-trigger-path: e1:reduced:Negative_regulation >dobj >appos e2:recruitment:Bindingt+e2: ents2Label-mention-ngram: of SHARED andtae1: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt.e1: trigger-arg-path: reduced >dobj controlledt?trigger-to-trigger-path: e1:reduced:Negative_regulation >dobj [lemma='acetylation'] >appos [lemma='recruitment'] e2:recruitment:Bindingt;e2: trigger-arg-path: Binding >prep_of [lemma='p300'] themetQe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of Gene_or_gene_producttPe1: trigger-arg-path: Negative_regulation >dobj [lemma='acetylation'] controlledt0e2: trigger-arg-path: recruitment >prep_of themetFe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p53'] themet]e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of controllert_e2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p53'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj AcetylationtMe2: trigger-arg-path: recruitment:Binding >prep_of theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controllertGe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p300'] themet@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT significantlytBe1: trigger-arg-path: reduced:Negative_regulation >dobj controlledtJe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of themetFe1: trigger-arg-path: Negative_regulation >dobj controlled:AcetylationtVe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='acetylation'] AcetylationtYe1: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='acetylation'] AcetylationtIe2: trigger-arg-path: Binding >prep_of [lemma='p53'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='acetylation'] controlledtQe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='p300'] themet:e1: trigger-arg-path: reduced >dobj controlled:AcetylationtVe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='p300'] Gene_or_gene_producttre1: trigger-arg-path: Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] Gene_or_gene_producttNe1: trigger-arg-path: reduced:Negative_regulation >dobj controlled:Acetylationthe1: trigger-arg-path: Negative_regulation >nsubj [lemma='silencing'] >prep_of [lemma='hipk2'] controllerte2: trigger: recruitmenttNe2: trigger-arg-path: recruitment >prep_of [lemma='p300'] Gene_or_gene_productt1e1-label: Negative_regulation + e2-label: Bindingtptrigger-to-trigger-path: e1:phosphorylates:Positive_regulation conj_and >prep_at Sitetke2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:SitetMe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at site:Sitetae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] theme:Gene_or_gene_productt7e2: trigger-arg-path: interacts >conj_and >prep_at sitet1e2: args2Role-mention-ngram: THEME interacts witht"e2: ents2Label-mention-ngram: S155t1e2: args2Role-mention-ngram: phosphorylates THEMEt1e1: args2Role-mention-ngram: CONTROLLER interactst4e2: args2Role-mention-ngram: with and phosphorylatest0e1: args2Role-mention-ngram: with and CONTROLLEDtEe1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] controllert&e1: ents2Label-mention-ngram: and T163t)e1: ents2Label-mention-ngram: S155 , S159t5e1: ents2Label-mention-ngram: with and phosphorylatest*e2: args2Role-mention-ngram: THEME at S155t0e1: ents2Label-mention-ngram: interacts with andt}e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj theme:Gene_or_gene_productt^e2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitet,e2: ents2Label-mention-ngram: SHARED at S155t'e2: ents2Label-mention-ngram: at S155 ,toe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitetie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetNe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj themet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at sitette2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitet]e2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetFe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj themetJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] controllertAe2: trigger-arg-path: interacts >nsubj theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] themet6e1: ents2Label-mention-ngram: phosphorylates SHARED att$e1: ents2Label-mention-ngram: S155 ,t e1: ents2Label-mention-ngram: att/e2: args2Role-mention-ngram: and phosphorylatest5e2: args2Role-mention-ngram: and phosphorylates THEMEt&e2: args2Role-mention-ngram: at S155 ,t5e2: ents2Label-mention-ngram: with and phosphorylatest]e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj Gene_or_gene_productt+e2: args2Role-mention-ngram: phosphorylatest(e1: ents2Label-mention-ngram: , and T163t%e2: ents2Label-mention-ngram: at S155tTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_productte2: args2Role-mention-ngram: attwe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitet(e1: ents2Label-mention-ngram: S159 , andt0e2: ents2Label-mention-ngram: interacts with andtae2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitet%e2: args2Role-mention-ngram: with andtee2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themet=e2: trigger-arg-path: interacts:Binding >conj_and >dobj themetPe2: trigger-arg-path: interacts >nsubj [lemma='gsk3'] theme:Gene_or_gene_productte1: ents2Label-mention-ngram: ,tOe1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] Gene_or_gene_productt%e2: args2Role-mention-ngram: THEME att?e2: trigger-arg-path: interacts:Binding >conj_and >prep_at sitet/e2: args2Role-mention-ngram: interacts with andt'e1: ents2Label-mention-ngram: at S155 ,t0e2: ents2Label-mention-ngram: and phosphorylatest7e2: trigger-arg-path: interacts >conj_and >prep_at SitetPe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at sitetVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] controllertJe2: trigger-arg-path: interacts >conj_and >dobj theme:Gene_or_gene_productt:e2: trigger-arg-path: Binding >conj_and >prep_at site:SitetTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] themet%e1: args2Role-mention-ngram: with andt$e2: ents2Label-mention-ngram: S155 ,t(e2: args2Role-mention-ngram: S155 , SITEt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttDe2: trigger-arg-path: interacts >conj_and >dobj Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttre2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: with andt[e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj theme:Gene_or_gene_producttle2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: and phosphorylates SHAREDt&e1: ents2Label-mention-ngram: with andt"e1: ents2Label-mention-ngram: S159tHe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at Sitet,e2: args2Role-mention-ngram: THEME interactst%e1: ents2Label-mention-ngram: at S155t!e2: args2Role-mention-ngram: S155tfe2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitet?e2: trigger-arg-path: interacts:Binding >conj_and >prep_at Sitet&e1: ents2Label-mention-ngram: , S159 ,t#e1: ents2Label-mention-ngram: , andtCe2: trigger-arg-path: interacts:Binding >nsubj Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at site:Sitet#e2: args2Role-mention-ngram: , SITEt?e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_productte2: trigger: interactstYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] controllerte2: SITE: 2t$e2: args2Role-mention-ngram: at S155t$e1: ents2Label-mention-ngram: , S159t;e2: trigger-arg-path: interacts >nsubj Gene_or_gene_producttRe2: trigger-arg-path: interacts:Binding >conj_and >dobj theme:Gene_or_gene_productt\e2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] controllertconj_and >prep_at site:SitetCe2: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] themet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themet9e2: trigger-arg-path: Binding >nsubj [lemma='gsk3'] themet"e2: ents2Label-mention-ngram: S159t;e2: trigger-arg-path: interacts >nsubj [lemma='gsk3'] themet6e1: args2Role-mention-ngram: CONTROLLER interacts witht5e2: trigger-arg-path: interacts >conj_and >dobj themet#e2: args2Role-mention-ngram: S155 ,t7e1: ents2Label-mention-ngram: and phosphorylates SHAREDt"e1: ents2Label-mention-ngram: T163tpe2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED at S155tfe2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitet[e2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_productt\e2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitetke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttDe2: trigger-arg-path: interacts:Binding >conj_and >prep_at site:Sitet)e2: ents2Label-mention-ngram: S155 , S159t"e1: ents2Label-mention-ngram: S155tNe2: trigger-arg-path: Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >conj_and >prep_at sitetze2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at Sitetne2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetce2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:SitetZe1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttRe2: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] Gene_or_gene_producttne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: interacts with andt$e2: ents2Label-mention-ngram: , S159t^e2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitet$e1: ents2Label-mention-ngram: S159 ,tIe2: trigger-arg-path: interacts:Binding >nsubj theme:Gene_or_gene_producttJe2: trigger-arg-path: interacts >nsubj [lemma='gsk3'] Gene_or_gene_producttte2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_productt4e2: args2Role-mention-ngram: phosphorylates THEME att,e2: trigger-arg-path: interacts >nsubj themet]trigger-to-trigger-path: e1:phosphorylates:Positive_regulation conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitet4e2: trigger-arg-path: interacts:Binding >nsubj themetje2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitet[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] Gene_or_gene_producttXe2: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED att0e1: ents2Label-mention-ngram: and phosphorylatestHe2: trigger-arg-path: Binding >nsubj [lemma='gsk3'] Gene_or_gene_producttLe2: trigger-arg-path: interacts:Binding >conj_and >dobj Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] themetXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] themetue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] Gene_or_gene_producttBe1: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] themet`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] themet]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttNe1: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] themetFe2: ents2Label-mention-ngram: interaction between GENE_OR_GENE_PRODUCTtce2: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttWe2: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttWe2: trigger-arg-path: Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_producttFe2: trigger-arg-path: interaction >prep_between [lemma='beclin'] themetBe2: trigger-arg-path: Binding >prep_between [lemma='beclin'] themetme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] Gene_or_gene_producttUe1: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] Gene_or_gene_producttante: same-senttge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] themetBe1: trigger-arg-path: Binding >prep_between [lemma='beclin'] themetoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] Gene_or_gene_producttNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] themetme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] themet[e1: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttUe2: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='beclin'] Gene_or_gene_producttNe1: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] themet]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_between [lemma='beclin'] Gene_or_gene_productt]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] Gene_or_gene_productt[e2: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_productt[e2: trigger-arg-path: interaction >prep_between [lemma='beclin'] theme:Gene_or_gene_productt:e2: ents2Label-mention-ngram: between GENE_OR_GENE_PRODUCTtWe1: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] themet[e1: trigger-arg-path: interaction >prep_between [lemma='beclin'] theme:Gene_or_gene_producttNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] themetXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] themetWe1: trigger-arg-path: Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interaction >prep_between [lemma='beclin'] themet`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] themetoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_producttKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and GENE_OR_GENE_PRODUCTtUe1: trigger-arg-path: interaction >prep_between [lemma='beclin'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-xl'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='beclin'] themetoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_productt]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] Gene_or_gene_producttce1: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_productt1e1-label: Generic_event + e2-label: Generic_eventtce2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_productt>e2: ents2Label-mention-ngram: between GENE_OR_GENE_PRODUCT andtUe2: trigger-arg-path: interaction >prep_between [lemma='beclin'] Gene_or_gene_producttFe2: trigger-arg-path: interaction >prep_between [lemma='bcl-xl'] themet6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT andtce1: trigger-arg-path: interaction:Binding >prep_between [lemma='beclin'] theme:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-xl'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_between [lemma='beclin'] Gene_or_gene_producttBe2: trigger-arg-path: Binding >prep_between [lemma='bcl-xl'] themet(interceding-token ngrams: : ATM enhancest.e1: args2Role-mention-ngram: CONTROLLER kinasetye1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='kinase'] >nn [lemma='ATM'] controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: activity , whichtqe1: trigger-arg-path: triggers:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] Gene_or_gene_productt'e2: args2Role-mention-ngram: activity ,tRe2: trigger-arg-path: promotes:Positive_regulation nn Gene_or_gene_productt/e2: trigger-arg-path: promotes >dobj controlledtdobj [lemma='ubiquitination'] controlled:Ubiquitinationt>e1: trigger-arg-path: Negative_activation >dobj >nn controlledt-e1: ents2Label-mention-ngram: triggers SHAREDtne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: ligaset+interceding-token ngrams: degradation : ATMtTe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj >nn Familytje2: trigger-arg-path: promotes:Positive_regulation nn [lemma='itch'] controllert|e2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='itch'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=promote nn controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=promote >dobj controlledtTe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj controlledt,e2: args2Role-mention-ngram: ligase activityt0e2: args2Role-mention-ngram: E3-ubiquitin ligasetYe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj >nn controllertGe2: trigger-arg-path: promotes:Positive_regulation >dobj UbiquitinationtDe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj >nn controlledt_e1: trigger-arg-path: triggers >dobj [lemma='degradation'] >nn [lemma='flip'] controlled:Familyt$e1: ents2Label-mention-ngram: kinaset>e1: trigger-arg-path: triggers >nsubj >nn Gene_or_gene_producttWe2: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt`e2: trigger-arg-path: promotes nn [lemma='itch'] Gene_or_gene_producttCe2: trigger-arg-path: promotes:Positive_regulation >dobj controlledtke2: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtce1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlledt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinaset&e2: ents2Label-mention-ngram: activityt%e2: args2Role-mention-ngram: which int?e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >nn Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='itch'] controllert4e1: ents2Label-mention-ngram: kinase triggers SHAREDt0e1: args2Role-mention-ngram: triggers CONTROLLEDtHe1: trigger-arg-path: triggers:Negative_activation >nsubj >nn controllert:e1: trigger-arg-path: Negative_activation >dobj >nn Familytbe2: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtle1: trigger-arg-path: triggers:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlledtRe2: trigger-arg-path: promotes:Positive_regulation >dobj controlled:Ubiquitinationthe1: trigger-arg-path: triggers >nsubj [lemma='kinase'] >nn [lemma='ATM'] controller:Gene_or_gene_producttIe1: trigger-arg-path: triggers >nsubj >nn controller:Gene_or_gene_producttge1: trigger-arg-path: triggers:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controllertEe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >nn controllertSe1: trigger-arg-path: triggers >nsubj [lemma='kinase'] >nn [lemma='ATM'] controllert7e1: args2Role-mention-ngram: CONTROLLER kinase triggerstNe1: trigger-arg-path: triggers:Negative_activation >dobj >nn controlled:Familyt2e2: ents2Label-mention-ngram: turn promotes SHAREDt#e1: all-labels: Negative_activationtXe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj >nn controlledt(e2: ents2Label-mention-ngram: , which int%e2: args2Role-mention-ngram: promotestTe1: trigger-arg-path: triggers >dobj [lemma='degradation'] >nn [lemma='flip'] Familyt#e2: args2Role-mention-ngram: ligasetIe2: trigger-arg-path: promotes nn controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] FamilytIe1: trigger-arg-path: Negative_activation >nsubj >nn Gene_or_gene_productt&interceding-token ngrams: ATM enhancest?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='itch'] Gene_or_gene_productt%e1: args2Role-mention-ngram: triggerstke2: trigger-arg-path: promotes nn [lemma='itch'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='degradation'] >nn [lemma='flip'] FamilytYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controllert'e2: args2Role-mention-ngram: , which intztrigger-to-trigger-path: e1:triggers:Negative_activation parataxis >dobj >rcmod e2:promotes:Positive_regulationt\e2: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] controlledt]e1: trigger-arg-path: triggers >nsubj [lemma='kinase'] >nn [lemma='ATM'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: which intOe2: trigger-arg-path: lemmatizedTrigger=promote >dobj controlled:Ubiquitinationt9e2: args2Role-mention-ngram: E3-ubiquitin ligase activityt&e1: ents2Label-mention-ngram: triggerstRe1: trigger-arg-path: triggers:Negative_activation >nsubj >nn Gene_or_gene_productt#e1: args2Role-mention-ngram: kinaset;e2: args2Role-mention-ngram: CONTROLLER E3-ubiquitin ligasetqe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='ubiquitination'] UbiquitinationtHe2: trigger-arg-path: promotes:Positive_regulation nn controllert=e1-label: Negative_activation + e2-label: Positive_regulationtte2: trigger-arg-path: promotes:Positive_regulation nn [lemma='itch'] Gene_or_gene_productt5e2: args2Role-mention-ngram: turn promotes CONTROLLEDt!e2: args2Role-mention-ngram: turntKe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj >nn controlled:Familyt*e2: ents2Label-mention-ngram: E3-ubiquitintXe1: trigger-arg-path: triggers >dobj [lemma='degradation'] >nn [lemma='flip'] controlledte1: label: Negative_activationtSe2: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] controlledtce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='itch'] controller:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=trigger >dobj >nn Familytme2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='ubiquitination'] controlledt>e2: trigger-arg-path: promotes nn Gene_or_gene_productt3e2: trigger-arg-path: promotes >dobj Ubiquitinationt&e2: ents2Label-mention-ngram: promotest?e1: trigger-arg-path: Negative_activation >nsubj >nn controllert,e1: args2Role-mention-ngram: kinase triggerstXe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj Ubiquitinationtse1: trigger-arg-path: triggers:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlled:FamilytZe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >nn controller:Gene_or_gene_productthe1: trigger-arg-path: triggers:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] Familyt4e2: args2Role-mention-ngram: CONTROLLER E3-ubiquitint-e2: ents2Label-mention-ngram: promotes SHAREDt'interceding-token ngrams: degradation :tqe2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='itch'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj >nn Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='itch'] controllertne1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='kinase'] >nn [lemma='ATM'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='kinase'] >nn [lemma='ATM'] controllert*e2: args2Role-mention-ngram: which in turntTe1: trigger-arg-path: Negative_activation >nsubj >nn controller:Gene_or_gene_producttFe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT E3-ubiquitin ligaset.e2: ents2Label-mention-ngram: activity , whichtGe1: trigger-arg-path: triggers:Negative_activation >dobj >nn controlledthe1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] controlledtie1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='degradation'] >nn [lemma='flip'] controlledte1: trigger: triggersthe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt]e2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] Ubiquitinationt]e1: trigger-arg-path: triggers:Negative_activation >nsubj >nn controller:Gene_or_gene_productt%interceding-token ngrams: degradationt:e1: trigger-arg-path: triggers >dobj >nn controlled:Familytae2: trigger-arg-path: Positive_regulation nn [lemma='itch'] controllert?trigger-to-trigger-path: e1:triggers:Negative_activation parataxis [lemma='enhance'] >dobj [lemma='activity'] >rcmod [lemma='promote'] e2:promotes:Positive_regulationtje1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlled:Familyt?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT E3-ubiquitint*e2: args2Role-mention-ngram: turn promotest?e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controller:Gene_or_gene_productte2: trigger: promotest8interceding-tokens-full-span: degradation : ATM enhancest)e2: args2Role-mention-ngram: E3-ubiquitintHe2: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] controlledt.e2: ents2Label-mention-ngram: in turn promotestinterceding-token ngrams: :t7e1: args2Role-mention-ngram: kinase triggers CONTROLLEDtCe1: trigger-arg-path: triggers:Negative_activation >dobj >nn Familytse1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: E3-ubiquitin ligasetEe1: trigger-arg-path: Negative_activation >dobj >nn controlled:Familyt%e2: ents2Label-mention-ngram: in turntxe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controllert^e1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controllert0e2: args2Role-mention-ngram: promotes CONTROLLEDtWe2: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlled:Familytinterceding-token ngrams: ATMtne1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >nsubj >nn controller:Gene_or_gene_productt_e1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] Familyt`e2: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationtpe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='degradation'] >nn [lemma='flip'] controlled:Familytve2: trigger-arg-path: Positive_regulation nn [lemma='itch'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: which in turntLe2: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] Ubiquitinationt.e2: args2Role-mention-ngram: ligase activity ,t4e2: trigger-arg-path: promotes nn controllert-e1: ents2Label-mention-ngram: kinase triggerste2: trigger-arg-path: promotes:Positive_regulation nn [lemma='itch'] controller:Gene_or_gene_productt8shortest-path: parataxis >dobj >nnt?shortest-path: parataxis [lemma='enhance'] >dobj [lemma='activity'] >nn [lemma='itch']tke2: trigger-arg-path: Positive_regulation nn [lemma='itch'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: turnt-e2: args2Role-mention-ngram: in turn promotest}e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj [lemma='degradation'] >nn [lemma='flip'] controlledt/e1: trigger-arg-path: triggers >dobj >nn Familyt+e2: ents2Label-mention-ngram: turn promotestEe2: trigger-arg-path: lemmatizedTrigger=promote nn controllert>e2: trigger-arg-path: promotes >dobj controlled:Ubiquitinationt:e2: ents2Label-mention-ngram: E3-ubiquitin ligase activitytce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj controlled:Ubiquitinationt(e2: ents2Label-mention-ngram: activity ,te2: incoming: nn Gene_or_gene_producttVe2: trigger-arg-path: promotes nn [lemma='itch'] controllert"interceding-token ngrams: enhancestBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinase triggerst-e2: ents2Label-mention-ngram: ligase activityt$e2: args2Role-mention-ngram: in turntinterceding-token ngrams: : ATMt4e1: trigger-arg-path: triggers >nsubj >nn controllert]e2: trigger-arg-path: promotes:Positive_regulation nn controller:Gene_or_gene_productt|e1: trigger-arg-path: triggers:Negative_activation >nsubj [lemma='kinase'] >nn [lemma='ATM'] controller:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=promote >dobj Ubiquitinationt3e1: trigger-arg-path: triggers >dobj >nn controlledt_e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_activation >dobj >nn controlled:Familyt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='cnk'] themet[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] Gene_or_gene_productt/e1: trigger-arg-path: binds:Binding >dobj themet1e2: ents2Label-mention-ngram: SHARED binds SHAREDtJe2: trigger-arg-path: binds >dobj [lemma='raf'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] Gene_or_gene_producttKe2: trigger-arg-path: binds >nsubj [lemma='cnk'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >dobj [lemma='raf'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >dobj [lemma='raf'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: THEME binds THEMEtFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] Gene_or_gene_producttEe1: trigger-arg-path: binds >nsubj [lemma='cnk'] Gene_or_gene_productt5e1: trigger-arg-path: binds >dobj [lemma='raf'] themetdobj theme:Gene_or_gene_productt7e2: trigger-arg-path: Binding >dobj [lemma='raf'] themet(e2: args2Role-mention-ngram: binds THEMEtDe2: trigger-arg-path: binds >dobj [lemma='raf'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: binds SHAREDt>e1: trigger-arg-path: binds:Binding >dobj Gene_or_gene_productt*e2: ents2Label-mention-ngram: binds SHAREDtJe1: trigger-arg-path: binds >dobj [lemma='raf'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] themet7e1: trigger-arg-path: Binding >dobj [lemma='raf'] themet8e1: trigger-arg-path: Binding >nsubj [lemma='cnk'] themet(e1: args2Role-mention-ngram: binds THEMEtMe1: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] Gene_or_gene_producttRe2: trigger-arg-path: binds:Binding >dobj [lemma='raf'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binds:Binding >dobj [lemma='raf'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] theme:Gene_or_gene_productt'e1: trigger-arg-path: binds >dobj themetMe2: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='cnk'] Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME binds THEMEtNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] themet5e2: trigger-arg-path: binds >dobj [lemma='raf'] themetLe1: trigger-arg-path: binds:Binding >dobj [lemma='raf'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] themetGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] themet=e1: trigger-arg-path: binds:Binding >dobj [lemma='raf'] themet1e1: ents2Label-mention-ngram: SHARED binds SHAREDtde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] themetEe2: trigger-arg-path: binds >nsubj [lemma='cnk'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] Gene_or_gene_producttFe1: trigger-arg-path: Binding >dobj [lemma='raf'] Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding >nsubj [lemma='cnk'] themetMe2: trigger-arg-path: Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] themet6e1: trigger-arg-path: binds >dobj Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='cnk'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='cnk'] themet=e2: trigger-arg-path: binds:Binding >dobj [lemma='raf'] themetGe2: trigger-arg-path: Binding >nsubj [lemma='cnk'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='raf'] Gene_or_gene_producttDe1: trigger-arg-path: binds:Binding >dobj theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >dobj [lemma='raf'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] themetLe2: trigger-arg-path: Binding >dobj [lemma='raf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: binds >dobj [lemma='raf'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='cnk'] Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='cnk'] themetKe1: trigger-arg-path: binds >nsubj [lemma='cnk'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='raf'] Gene_or_gene_producttHe1: trigger-arg-path: target >prep_of [lemma='p73'] Gene_or_gene_producttBe2: args2Role-mention-ngram: CONTROLLED transcriptional activationtLe2: trigger-arg-path: activation >prep_by [lemma='p73'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='p73'] Gene_or_gene_productt8e2: trigger-arg-path: Positive_activation >nn controlledt*e1: ents2Label-mention-ngram: was a directtZe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by controllertGe2: trigger-arg-path: activation >nn [lemma='pml'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='pml'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='pml'] themet7e1: ents2Label-mention-ngram: transcriptional target oftGe1: trigger-arg-path: Binding >nsubj [lemma='pml'] Gene_or_gene_producttHe2: trigger-arg-path: activation:Positive_activation >prep_by controllert+e2: ents2Label-mention-ngram: activation byt'interceding-token ngrams: YAP , showingt4e2: ents2Label-mention-ngram: SHARED transcriptionalt4e2: trigger-arg-path: activation >prep_by controllertKe2: trigger-arg-path: Positive_activation >prep_by [lemma='p73'] controllertPe1: trigger-arg-path: target:Binding >prep_of [lemma='p73'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='pml'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME was atKe2: trigger-arg-path: lemmatizedTrigger=activation >nn Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='p73'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_of [lemma='p73'] themetPe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by Gene_or_gene_producttLe1: trigger-arg-path: target >nsubj [lemma='pml'] theme:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='p73'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=activation >prep_by controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn Gene_or_gene_producttVe2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='p73'] controllertQe2: trigger-arg-path: activation:Positive_activation >nn [lemma='pml'] controlledt,e1: args2Role-mention-ngram: transcriptionalt*e1: ents2Label-mention-ngram: SHARED was atGe2: trigger-arg-path: Positive_activation >prep_by Gene_or_gene_productt`e2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='p73'] Gene_or_gene_productt3e1: args2Role-mention-ngram: direct transcriptionalt/e2: trigger-arg-path: activation >nn controlledtfe2: trigger-arg-path: activation:Positive_activation >nn [lemma='pml'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='p73'] themetNe1: trigger-arg-path: target:Binding >nsubj [lemma='pml'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pml'] controlledt;e1: ents2Label-mention-ngram: direct transcriptional targettfe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='pml'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pml'] controlled:Gene_or_gene_productt4e1: ents2Label-mention-ngram: direct transcriptionalt8e2: ents2Label-mention-ngram: transcriptional activationt6e1: args2Role-mention-ngram: transcriptional target oft4interceding-tokens-full-span: and YAP , showing thatthe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='p73'] theme:Gene_or_gene_producttinterceding-token ngrams: YAP ,tYe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pml'] Gene_or_gene_producttWe2: trigger-arg-path: activation >prep_by [lemma='p73'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=activation >nn controlled:Gene_or_gene_productt=e2: trigger-arg-path: Positive_activation >prep_by controllerte2: trigger: activationtIe2: trigger-arg-path: activation >prep_by controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: directt!interceding-token ngrams: showingt?e2: ents2Label-mention-ngram: SHARED transcriptional activationt(interceding-token ngrams: , showing thattXe2: trigger-arg-path: activation:Positive_activation >nn controlled:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='pml'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pml'] Gene_or_gene_productt5e2: args2Role-mention-ngram: activation by CONTROLLERtCe2: trigger-arg-path: activation:Positive_activation >nn controlledt}shortest-path: vmod [lemma='show'] >ccomp [lemma='be'] >nsubj [lemma='activation'] >nn [lemma='pml']tUe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controlledt6e1: ents2Label-mention-ngram: a direct transcriptionalt-e2: ents2Label-mention-ngram: transcriptionalt%e1: args2Role-mention-ngram: a directt=e2: trigger-arg-path: activation >nn [lemma='pml'] controlledt7e2: args2Role-mention-ngram: transcriptional activationtVe1: trigger-arg-path: target:Binding >prep_of [lemma='p73'] theme:Gene_or_gene_productt#interceding-token ngrams: , showingtbe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='p73'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pml'] controlledt?trigger-to-trigger-path: e1:target:Binding >vmod [lemma='show'] >ccomp [lemma='be'] >nsubj [lemma='activation'] e2:activation:Positive_activationt&e1: ents2Label-mention-ngram: a directtinterceding-token ngrams: YAPt8e1: trigger-arg-path: Binding >nsubj [lemma='pml'] themetBe2: trigger-arg-path: Positive_activation >nn Gene_or_gene_productt[e2: trigger-arg-path: Positive_activation >nn [lemma='pml'] controlled:Gene_or_gene_productt2e2: ents2Label-mention-ngram: activation by SHAREDtFe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by controllertAe1: trigger-arg-path: target:Binding >prep_of [lemma='p73'] themet3e1: args2Role-mention-ngram: transcriptional targettde2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by Gene_or_gene_productt9e2: trigger-arg-path: activation >nn Gene_or_gene_productt5e1: args2Role-mention-ngram: a direct transcriptionalt)e1: args2Role-mention-ngram: was a directt?e1: trigger-arg-path: target:Binding >nsubj [lemma='pml'] themet#interceding-token ngrams: and YAP ,t]e2: trigger-arg-path: activation:Positive_activation >prep_by controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: transcriptionalt[e2: trigger-arg-path: activation:Positive_activation >nn [lemma='pml'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pml'] controlled:Gene_or_gene_producttRe2: trigger-arg-path: Positive_activation >prep_by controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: target of SHAREDtFe2: trigger-arg-path: Positive_activation >nn [lemma='pml'] controlledtOe1: trigger-arg-path: Binding >prep_of [lemma='p73'] theme:Gene_or_gene_productt#e1: args2Role-mention-ngram: directt4e1: ents2Label-mention-ngram: transcriptional targettTe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='p73'] controllertje2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controlled:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='p73'] themetie2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='p73'] controller:Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=activation >nn controlledt:e1: args2Role-mention-ngram: direct transcriptional targett`e1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='pml'] Gene_or_gene_productt9e1: trigger-arg-path: target >prep_of [lemma='p73'] themet-shortest-path: vmod >ccomp >nsubj >nntRe2: trigger-arg-path: activation >nn [lemma='pml'] controlled:Gene_or_gene_productt`trigger-to-trigger-path: e1:target:Binding >vmod >ccomp >nsubj e2:activation:Positive_activationtre2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='p73'] Gene_or_gene_productt!interceding-token ngrams: and YAPtMe2: trigger-arg-path: Positive_activation >nn controlled:Gene_or_gene_productt-e1: ents2Label-mention-ngram: transcriptionaltFe1: trigger-arg-path: target >nsubj [lemma='pml'] Gene_or_gene_productt#e1: ents2Label-mention-ngram: was atUe2: trigger-arg-path: Positive_activation >prep_by [lemma='p73'] Gene_or_gene_productt"e1: args2Role-mention-ngram: was at>e2: trigger-arg-path: activation >prep_by Gene_or_gene_producttMe2: trigger-arg-path: activation:Positive_activation >nn Gene_or_gene_productt`e2: trigger-arg-path: Positive_activation >prep_by [lemma='p73'] controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='p73'] controllertNe1: trigger-arg-path: target >prep_of [lemma='p73'] theme:Gene_or_gene_producttRe2: trigger-arg-path: activation:Positive_activation >prep_by Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_of [lemma='p73'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='p73'] controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='pml'] themet7e2: args2Role-mention-ngram: CONTROLLED transcriptionalt7e1: trigger-arg-path: target >nsubj [lemma='pml'] themet&interceding-token ngrams: showing thatt*e2: args2Role-mention-ngram: activation bytke2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='p73'] controller:Gene_or_gene_productt:e2: args2Role-mention-ngram: transcriptional activation bytBe2: trigger-arg-path: activation >prep_by [lemma='p73'] controllertTe1: trigger-arg-path: target:Binding >nsubj [lemma='pml'] theme:Gene_or_gene_productt;e2: ents2Label-mention-ngram: transcriptional activation bytDe2: trigger-arg-path: activation >nn controlled:Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation >nn [lemma='pml'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='ra'] >nn [lemma='gtp'] controllert2e1: args2Role-mention-ngram: CONTROLLER loaded RAStUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj [lemma='activation'] >prep_of [lemma='raf'] controlledt&e1: ents2Label-mention-ngram: RAS thentdobj [lemma='activation'] >prep_of [lemma='raf'] controlled:Gene_or_gene_productt@e2: trigger-arg-path: phosphorylates dobj >prep_of controlledtje1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='ra'] >nn [lemma='gtp'] Gene_or_gene_productt,interceding-token ngrams: phosphorylates andt*e1: args2Role-mention-ngram: then triggerst?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='raf'] controlledt$e1: ents2Label-mention-ngram: loadedt6e2: trigger-arg-path: phosphorylates nsubj [lemma='ra'] >nn [lemma='gtp'] controller:Gene_or_gene_producttXinterceding-tokens-full-span: , MEK , and MAPK ; active RAF phosphorylates and activatest/e2: args2Role-mention-ngram: CONTROLLER , whicht$interceding-token ngrams: , and MAPKtBe1: trigger-arg-path: triggers >dobj >prep_of Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] Gene_or_gene_producttpe1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='raf'] Gene_or_gene_producttee1: trigger-arg-path: triggers >dobj [lemma='activation'] >prep_of [lemma='raf'] Gene_or_gene_producttvtrigger-to-trigger-path: e1:triggers:Positive_activation >parataxis >dobj >rcmod e2:phosphorylates:Positive_regulationt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT loadedt^e2: trigger-arg-path: Positive_regulation nsubj >nn Gene_or_gene_producttoshortest-path: parataxis [lemma='phosphorylate'] >dobj [lemma='mek']t!interceding-token ngrams: , MEK ,t*e1: ents2Label-mention-ngram: triggers thetve1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='activation'] >prep_of [lemma='raf'] Gene_or_gene_producttce1: trigger-arg-path: triggers:Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] controllert+e2: ents2Label-mention-ngram: and activatestinterceding-token ngrams: , MEKt6interceding-token ngrams: phosphorylates and activatestde1: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: RAS then triggerstZe1: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] controllert!e1: ents2Label-mention-ngram: RASt'e1: args2Role-mention-ngram: sequentialt-e1: ents2Label-mention-ngram: loaded RAS thentRe1: trigger-arg-path: triggers:Positive_activation >nsubj >nn Gene_or_gene_productt&interceding-token ngrams: ; active RAFtinterceding-token ngrams: RAFt"interceding-token ngrams: and MAPKtinterceding-token ngrams: MAPKtYe1: trigger-arg-path: triggers >nsubj [lemma='ra'] >nn [lemma='gtp'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj >nn controller:Gene_or_gene_productt[e1: trigger-arg-path: triggers >dobj [lemma='activation'] >prep_of [lemma='raf'] controlledtVe1: trigger-arg-path: triggers:Positive_activation >dobj >prep_of Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj >prep_of Gene_or_gene_producttfe1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='raf'] controlledtpe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj >prep_of Gene_or_gene_productt@e1: ents2Label-mention-ngram: activation of GENE_OR_GENE_PRODUCTt'interceding-token ngrams: and activatest'interceding-token ngrams: MAPK ; activetce1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >nsubj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: in turn CONTROLLEDtPe2: trigger-arg-path: Positive_regulation nsubj >nn controllert0interceding-token ngrams: RAF phosphorylates andt$interceding-token ngrams: active RAFt'e1: args2Role-mention-ngram: loaded RASt*shortest-path: parataxis >dobjt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='raf'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: in turn phosphorylatestme1: trigger-arg-path: triggers:Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] controller:Gene_or_gene_productt]e1: trigger-arg-path: triggers:Positive_activation >nsubj >nn controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: turn phosphorylatestMe1: trigger-arg-path: triggers >dobj >prep_of controlled:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='ra'] >nn [lemma='gtp'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: then triggerst+e1: args2Role-mention-ngram: the sequentialt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj >prep_of controlled:Gene_or_gene_producttpe1: trigger-arg-path: triggers >dobj [lemma='activation'] >prep_of [lemma='raf'] controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj [lemma='activation'] >prep_of [lemma='raf'] controlled:Gene_or_gene_producttEe2: trigger-arg-path: Positive_regulation nsubj [lemma='ra'] >nn [lemma='gtp'] controllert_e2: trigger-arg-path: phosphorylates:Positive_regulation nsubj >nn controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: sequential activation oftIe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj >prep_of controlledt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , whicht(interceding-token ngrams: phosphorylatestoe1: trigger-arg-path: triggers:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='raf'] controlledt$interceding-token ngrams: and MAPK ;t,e2: args2Role-mention-ngram: turn CONTROLLEDt8e1: trigger-arg-path: triggers >dobj >prep_of controlledt,e1: args2Role-mention-ngram: loaded RAS thentre1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttae1: trigger-arg-path: triggers:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt?trigger-to-trigger-path: e1:triggers:Positive_activation >parataxis [lemma='phosphorylate'] >dobj [lemma='mek'] >rcmod [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationt`e1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='ra'] >nn [lemma='gtp'] controllert)e1: args2Role-mention-ngram: triggers thet,interceding-token ngrams: RAF phosphorylatest.e1: args2Role-mention-ngram: RAS then triggerst3e1: ents2Label-mention-ngram: sequential activationtLe1: trigger-arg-path: triggers:Positive_activation >dobj >prep_of controlledtinterceding-token ngrams: MEK ,t interceding-token ngrams: MAPK ;t=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT loaded RAStoe1: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] >nn [lemma='gtp'] controller:Gene_or_gene_producttNe2: trigger-arg-path: phosphorylates dobj [lemma='activation'] >prep_of [lemma='raf'] Gene_or_gene_producttJe2: trigger-arg-path: phosphorylates:Positive_regulation nsubj >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='activation'] >prep_of [lemma='raf'] controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: phosphorylates andt@e2: ents2Label-mention-ngram: and activates GENE_OR_GENE_PRODUCTt5e1: args2Role-mention-ngram: sequential activation oftYe2: trigger-arg-path: phosphorylates dobj [lemma='activation'] >prep_of [lemma='raf'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: sequential activationtee2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='ra'] >nn [lemma='gtp'] controller:Gene_or_gene_producttbe2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_producttYe2: trigger-arg-path: stimulated >nsubj [lemma='insulin'] controller:Gene_or_gene_productt~e1: trigger-arg-path: increased:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] Gene_or_gene_producttue1: trigger-arg-path: increased >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controller:Gene_or_gene_producttvtrigger-to-trigger-path: e1:increased:Negative_regulation >ccomp [lemma='stimulate'] e2:stimulated:Positive_regulationt,e1: ents2Label-mention-ngram: and associatedte1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: , or S6K1tqe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controllert!e1: args2Role-mention-ngram: S6K1t$e1: ents2Label-mention-ngram: RaptortAe1: ents2Label-mention-ngram: stimulated tyrosine phosphorylationt e1: args2Role-mention-ngram: butt*e1: args2Role-mention-ngram: CONTROLLER bytte1: trigger-arg-path: increased:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controllert4e1: args2Role-mention-ngram: CONTROLLER by rapamycint*e1: args2Role-mention-ngram: increased itst*e1: ents2Label-mention-ngram: S6K1 reducedt*e1: args2Role-mention-ngram: but increasedtWe2: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: SHARED stimulated tyrosinet,e1: args2Role-mention-ngram: or S6K1 reducedt:e1: ents2Label-mention-ngram: tyrosine phosphorylation andt!e1: args2Role-mention-ngram: mTORtnsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] Gene_or_gene_productt,e1: args2Role-mention-ngram: by rapamycin ort,e2: ents2Label-mention-ngram: and associatedt'e1: ents2Label-mention-ngram: , or S6K1t1e1: ents2Label-mention-ngram: S6K1 reduced serinet7e1: ents2Label-mention-ngram: serine phosphorylation oft_e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] Gene_or_gene_productt#e1: ents2Label-mention-ngram: , butt$e1: ents2Label-mention-ngram: mTOR ,t,shortest-path: ccomp >nsubjt3e1: args2Role-mention-ngram: rapamycin or knockdownt`e1: trigger-arg-path: increased >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controllert(e1: args2Role-mention-ngram: Raptor , ort?e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controllert"e1: args2Role-mention-ngram: , butt-e1: ents2Label-mention-ngram: , but increasedtbtrigger-to-trigger-path: e1:increased:Negative_regulation >ccomp e2:stimulated:Positive_regulationt:e1: trigger-arg-path: increased >nsubj >prep_of controllertzshortest-path: ccomp [lemma='stimulate'] >nsubj [lemma='insulin']t+e1: args2Role-mention-ngram: its CONTROLLEDt,e1: ents2Label-mention-ngram: reduced serinet*e1: ents2Label-mention-ngram: or knockdownt&e1: args2Role-mention-ngram: rapamycintse2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: its SHAREDtXe2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='insulin'] controllert+e1: ents2Label-mention-ngram: mTOR , Raptort.e1: args2Role-mention-ngram: knockdown of mTORt)e1: args2Role-mention-ngram: by rapamycintDe1: trigger-arg-path: increased >nsubj >prep_of Gene_or_gene_producttje1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controllertNe2: trigger-arg-path: stimulated >nsubj [lemma='insulin'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: rapamycin or knockdowntUe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of Gene_or_gene_productt#e1: args2Role-mention-ngram: Raptort:e2: ents2Label-mention-ngram: tyrosine phosphorylation andt/e1: ents2Label-mention-ngram: but increased itst,e1: args2Role-mention-ngram: or knockdown oft*e1: ents2Label-mention-ngram: knockdown oftie2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] controllert3e2: ents2Label-mention-ngram: and associated SHAREDt#e1: ents2Label-mention-ngram: IRS-1t(e1: ents2Label-mention-ngram: of IRS-1 ,t3e1: ents2Label-mention-ngram: and associated SHAREDt)e1: ents2Label-mention-ngram: IRS-1 , butt-e1: ents2Label-mention-ngram: or S6K1 reducedt!e1: args2Role-mention-ngram: , ort&e1: args2Role-mention-ngram: knockdowntOe1: trigger-arg-path: increased >nsubj >prep_of controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: IRS-1tMe2: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] controllert"e1: ents2Label-mention-ngram: S6K1t%e1: ents2Label-mention-ngram: of mTORt/e1: args2Role-mention-ngram: phosphorylation oft$e1: args2Role-mention-ngram: of mTORt(e2: ents2Label-mention-ngram: associatedt0e1: args2Role-mention-ngram: S6K1 reduced serinetDe2: trigger-arg-path: stimulated >nsubj [lemma='insulin'] controllert-e1: ents2Label-mention-ngram: by rapamycin ortnsubj >prep_of Gene_or_gene_productt1e1: ents2Label-mention-ngram: phosphorylation andt1e1: ents2Label-mention-ngram: stimulated tyrosinet3e1: args2Role-mention-ngram: serine phosphorylationt`e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: rapamycintKe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of controllertme2: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: Raptor ,t4e1: ents2Label-mention-ngram: serine phosphorylationte1: args2Role-mention-ngram: ,t+e1: ents2Label-mention-ngram: but increasedt8e2: ents2Label-mention-ngram: SHARED stimulated tyrosinet+e1: ents2Label-mention-ngram: increased itstje1: trigger-arg-path: increased >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: mTORt)e1: args2Role-mention-ngram: S6K1 reducedt6e1: ents2Label-mention-ngram: tyrosine phosphorylationt-e1: ents2Label-mention-ngram: or knockdown oft(e1: args2Role-mention-ngram: IRS-1 , buttie1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj >prep_of Gene_or_gene_productte1: trigger: increasedt,e1: args2Role-mention-ngram: phosphorylationtje2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: mTOR , Raptort_e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj >prep_of controllert6e1: ents2Label-mention-ngram: phosphorylation of IRS-1t{e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] controllert$e1: args2Role-mention-ngram: IRS-1 ,t/e1: ents2Label-mention-ngram: knockdown of mTORtNe1: trigger-arg-path: increased:Negative_regulation >nsubj >prep_of controllert'e1: args2Role-mention-ngram: , Raptor ,t!e1: ents2Label-mention-ngram: butt$e1: ents2Label-mention-ngram: serinet?e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: of IRS-1t?e1: trigger-arg-path: increased:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: its SHARED stimulatedt(e1: ents2Label-mention-ngram: , Raptor ,t"e1: ents2Label-mention-ngram: , ort&e1: ents2Label-mention-ngram: tyrosinet2e1: ents2Label-mention-ngram: increased its SHAREDt'e1: ents2Label-mention-ngram: of mTOR ,t5e1: args2Role-mention-ngram: phosphorylation of IRS-1t1e2: ents2Label-mention-ngram: phosphorylation andt1e2: ents2Label-mention-ngram: stimulated tyrosinet&e1: ents2Label-mention-ngram: of IRS-1t/e2: ents2Label-mention-ngram: associated SHAREDt)e1: args2Role-mention-ngram: or knockdowntbe2: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: reduced serinet%e1: ents2Label-mention-ngram: IRS-1 ,t(e1: ents2Label-mention-ngram: associatedt%e1: args2Role-mention-ngram: , Raptort.e1: args2Role-mention-ngram: but increased itst,e1: args2Role-mention-ngram: , but increasedt~e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_producttte1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: rapamycin ort&e1: ents2Label-mention-ngram: , Raptort?e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='mtorc1'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: itst#e1: args2Role-mention-ngram: serinet;e1: args2Role-mention-ngram: reduced serine phosphorylationtce1: trigger-arg-path: increased:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: Raptor , ort?e2: trigger-arg-path: phosphorylate >nsubj Gene_or_gene_productt&interceding-tokens-full-span: and thust5e1: trigger-arg-path: bind >dobj [lemma='axin'] themetRe1: trigger-arg-path: bind:Binding >dobj [lemma='axin'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: can nottXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gsk-3'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3'] controllert4e2: ents2Label-mention-ngram: does not phosphorylatetle2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3'] controller:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] controllertfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gsk-3'] theme:Gene_or_gene_productte1: incoming: dobj [lemma='axin'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gsk-3'] Gene_or_gene_productt^e2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj controller:Gene_or_gene_producttJe2: trigger-arg-path: phosphorylate >nsubj controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED can nott^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gsk-3'] theme:Gene_or_gene_producttne2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: CONTROLLER doest:e1: trigger-arg-path: Binding >nsubj [lemma='gsk-3'] themet e1: args2Role-mention-ngram: nottotrigger-to-trigger-path: e1:bind:Binding >conj_and [lemma='phosphorylate'] e2:phosphorylate:Positive_regulationt\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='axin'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: does not CONTROLLEDt+e2: args2Role-mention-ngram: not CONTROLLEDt+e1: args2Role-mention-ngram: not bind THEMEtce2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: not phosphorylatet@e2: ents2Label-mention-ngram: phosphorylate GENE_OR_GENE_PRODUCTtIe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj controllertUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: not bind GENE_OR_GENE_PRODUCTtIe1: trigger-arg-path: Binding >nsubj [lemma='gsk-3'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >dobj [lemma='axin'] Gene_or_gene_productt"interceding-token ngrams: and thustinterceding-token ngrams: thustZe2: trigger-arg-path: phosphorylate >nsubj [lemma='gsk-3'] controller:Gene_or_gene_producttMe1: trigger-arg-path: Binding >dobj [lemma='axin'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='axin'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: can not bindt?e1: trigger-arg-path: bind:Binding >nsubj [lemma='gsk-3'] themet*e1: args2Role-mention-ngram: THEME can nott?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] controller:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] Gene_or_gene_producttEe2: trigger-arg-path: phosphorylate >nsubj [lemma='gsk-3'] controllertke2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3'] controllert(e1: ents2Label-mention-ngram: SHARED cantOe1: trigger-arg-path: Binding >nsubj [lemma='gsk-3'] theme:Gene_or_gene_productt7e1: trigger-arg-path: bind >nsubj [lemma='gsk-3'] themetWe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3'] controllert%e1: args2Role-mention-ngram: not bindt7e1: ents2Label-mention-ngram: bind GENE_OR_GENE_PRODUCTtNe1: trigger-arg-path: bind:Binding >nsubj [lemma='gsk-3'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: not bindt`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3'] controller:Gene_or_gene_producttJe1: trigger-arg-path: bind >dobj [lemma='axin'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER does nott*e1: ents2Label-mention-ngram: can not bindtOe2: trigger-arg-path: phosphorylate >nsubj [lemma='gsk-3'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gsk-3'] themet8e1: trigger-arg-path: Binding >dobj [lemma='axin'] themetTe1: trigger-arg-path: bind:Binding >nsubj [lemma='gsk-3'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gsk-3'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='axin'] Gene_or_gene_producttLe1: trigger-arg-path: bind:Binding >dobj [lemma='axin'] Gene_or_gene_producttDe2: ents2Label-mention-ngram: not phosphorylate GENE_OR_GENE_PRODUCTtFe1: trigger-arg-path: bind >nsubj [lemma='gsk-3'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: SHARED doestLe1: trigger-arg-path: bind >nsubj [lemma='gsk-3'] theme:Gene_or_gene_productt]shortest-path: conj_and [lemma='phosphorylate'] >nsubj [lemma='gsk-3']t$e1: args2Role-mention-ngram: can nott!e1: ents2Label-mention-ngram: nottWtrigger-to-trigger-path: e1:bind:Binding >conj_and e2:phosphorylate:Positive_regulationtSe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='axin'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='axin'] themet-e2: ents2Label-mention-ngram: SHARED does nott5e2: trigger-arg-path: phosphorylate >nsubj controllert^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='axin'] Gene_or_gene_productt=e1: trigger-arg-path: bind:Binding >dobj [lemma='axin'] themetGe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj Simple_chemicalte2: trigger: promotingt1e2: args2Role-mention-ngram: promoting CONTROLLEDt/e2: ents2Label-mention-ngram: deacetylase SIRT1tde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj [lemma='amp'] controllert$e2: ents2Label-mention-ngram: ( AMPKtFe2: trigger-arg-path: Positive_regulation >dobj controlled:Acetylationt;e1: ents2Label-mention-ngram: kinase ( GENE_OR_GENE_PRODUCTthe2: trigger-arg-path: Positive_regulation nsubj [lemma='amp'] Simple_chemicalt)e2: args2Role-mention-ngram: inhibits thet,e2: ents2Label-mention-ngram: protein kinaset)e1: args2Role-mention-ngram: ( CONTROLLEDt8e2: args2Role-mention-ngram: phosphorylates and inhibitstie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj [lemma='amp'] Simple_chemicalt+e2: args2Role-mention-ngram: protein kinaset5e1: args2Role-mention-ngram: activated protein kinaset/e2: ents2Label-mention-ngram: SIRT1 , promotingt-e2: args2Role-mention-ngram: protein kinase (t)e2: args2Role-mention-ngram: and inhibitst-e2: args2Role-mention-ngram: inhibits the p53tne2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='amp'] Simple_chemicaltje2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='acetylation'] controlledt'e1: ents2Label-mention-ngram: activatedt#e2: args2Role-mention-ngram: ( AMPKt\e2: trigger-arg-path: promoting:Positive_regulation nsubj controller:Simple_chemicalt:e2: ents2Label-mention-ngram: promoting SHARED acetylationt.e1: ents2Label-mention-ngram: SHARED activatedt\e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controllert%e2: ents2Label-mention-ngram: SIRT1 ,t0e1: ents2Label-mention-ngram: SHARED deacetylaset6e1: trigger-arg-path: activated >nsubj Simple_chemicalt\e2: trigger-arg-path: Positive_regulation >dobj [lemma='acetylation'] controlled:AcetylationtYe2: trigger-arg-path: promoting nsubj [lemma='amp'] controllertstrigger-to-trigger-path: e1:activated:Positive_regulation >xcomp [lemma='promote'] e2:promoting:Positive_regulationt)e2: ents2Label-mention-ngram: acetylationt%e1: ents2Label-mention-ngram: proteint!e2: args2Role-mention-ngram: AMPKt.e1: ents2Label-mention-ngram: protein kinase (t;e2: trigger-arg-path: Positive_regulation >dobj Acetylationt$e2: args2Role-mention-ngram: the p53t)e1: ents2Label-mention-ngram: deacetylaset9e2: args2Role-mention-ngram: CONTROLLER activated proteint3e2: ents2Label-mention-ngram: p53 deacetylase SIRT1t6e1: ents2Label-mention-ngram: SHARED activated proteint0e2: ents2Label-mention-ngram: , promoting SHAREDt(e2: args2Role-mention-ngram: deacetylasete2: args2Role-mention-ngram: )t1e1: args2Role-mention-ngram: CONTROLLER activatedt1e1: trigger-arg-path: activated >nsubj controllert$e2: args2Role-mention-ngram: proteintGe2: trigger-arg-path: Positive_regulation nsubj Simple_chemicaltRe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Simple_chemicalt(e2: args2Role-mention-ngram: , promotingtAe2: trigger-arg-path: lemmatizedTrigger=promote >dobj Acetylationt%e1: ents2Label-mention-ngram: SIRT1 ,tEe2: trigger-arg-path: promoting:Positive_regulation >dobj Acetylationt6e2: ents2Label-mention-ngram: activated protein kinaset1e2: args2Role-mention-ngram: ) phosphorylates andt)e1: ents2Label-mention-ngram: , promotingtFe2: trigger-arg-path: promoting >dobj [lemma='acetylation'] controlledtatrigger-to-trigger-path: e1:activated:Positive_regulation >xcomp e2:promoting:Positive_regulationtDe2: trigger-arg-path: promoting:Positive_regulation >dobj controlledtJe1: trigger-arg-path: activated:Positive_regulation >nsubj Simple_chemicalt4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT )t0e2: args2Role-mention-ngram: the p53 deacetylaset'e1: ents2Label-mention-ngram: promotingtQe2: trigger-arg-path: Positive_regulation >dobj [lemma='acetylation'] AcetylationtUe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj AcetylationtHe2: trigger-arg-path: promoting nsubj controller:Simple_chemicalte1: ents2Label-mention-ngram: )t(shortest-path: dobj Acetylationt*e2: args2Role-mention-ngram: kinase ( AMPKtve2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='acetylation'] controlled:Acetylationt1e1: ents2Label-mention-ngram: deacetylase SIRT1 ,t6e1: ents2Label-mention-ngram: SHARED deacetylase SIRT1t^e2: trigger-arg-path: promoting nsubj [lemma='amp'] Simple_chemicaltOe1: trigger-arg-path: activated >nsubj [lemma='amp'] controller:Simple_chemicaltie2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='amp'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='amp'] Simple_chemicaltRe2: trigger-arg-path: promoting >dobj [lemma='acetylation'] controlled:Acetylationt1e1: ents2Label-mention-ngram: inhibits the SHAREDt}e2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='amp'] controller:Simple_chemicalt+e1: args2Role-mention-ngram: protein kinasetdobj controlled:AcetylationtAe1: trigger-arg-path: activated >nsubj controller:Simple_chemicalt%e2: args2Role-mention-ngram: kinase (tXe1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='amp'] Simple_chemicalt/e1: ents2Label-mention-ngram: activated proteint`e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj controlled:Acetylationt-e1: args2Role-mention-ngram: protein kinase (tYe1: trigger-arg-path: Positive_regulation >nsubj [lemma='amp'] controller:Simple_chemicalt9e1: ents2Label-mention-ngram: phosphorylates and inhibitstEe1: trigger-arg-path: activated:Positive_regulation >nsubj controllert$e2: ents2Label-mention-ngram: kinaset.e2: ents2Label-mention-ngram: and inhibits thet"e2: ents2Label-mention-ngram: AMPKte2: ents2Label-mention-ngram: )t5e2: args2Role-mention-ngram: activated protein kinaset!e2: ents2Label-mention-ngram: p53tPe2: trigger-arg-path: promoting:Positive_regulation >dobj controlled:Acetylationt1e2: args2Role-mention-ngram: CONTROLLER activatedt`e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='amp'] controller:Simple_chemicaltHe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controllertre2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='amp'] Simple_chemicalt[e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj Simple_chemicalt}e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='amp'] controllert$e2: ents2Label-mention-ngram: AMPK )t0e1: ents2Label-mention-ngram: phosphorylates andtLe2: trigger-arg-path: lemmatizedTrigger=promote >dobj controlled:Acetylationt+e2: ents2Label-mention-ngram: kinase ( AMPKtie2: trigger-arg-path: promoting nsubj [lemma='amp'] controller:Simple_chemicalt1e2: ents2Label-mention-ngram: deacetylase SIRT1 ,t.e2: ents2Label-mention-ngram: promoting SHAREDtSe1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='amp'] controllert0e2: ents2Label-mention-ngram: SHARED acetylationt*e1: ents2Label-mention-ngram: inhibits thet3e2: ents2Label-mention-ngram: AMPK ) phosphorylatest0e2: trigger-arg-path: promoting >dobj controlledt%e1: args2Role-mention-ngram: kinase (t*e2: ents2Label-mention-ngram: inhibits thet?e1: trigger-arg-path: activated >nsubj [lemma='amp'] controllert#e1: ents2Label-mention-ngram: SIRT1t2e1: ents2Label-mention-ngram: ) phosphorylates andte1: trigger: activatedt8e2: trigger-arg-path: promoting nsubj controllertLe2: trigger-arg-path: promoting:Positive_regulation nsubj controllert&e2: ents2Label-mention-ngram: kinase (tbe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='acetylation'] controlled:Acetylationte2: args2Role-mention-ngram: (t-e2: args2Role-mention-ngram: and inhibits thet&e1: ents2Label-mention-ngram: kinase (t-e2: ents2Label-mention-ngram: p53 deacetylasetCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ) phosphorylatestke2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='acetylation'] AcetylationtDe1: trigger-arg-path: activated >nsubj [lemma='amp'] Simple_chemicalt e2: args2Role-mention-ngram: p53t.e1: ents2Label-mention-ngram: and inhibits thet%e2: args2Role-mention-ngram: ( AMPK )t2e2: args2Role-mention-ngram: p53 deacetylase SIRT1t9e2: ents2Label-mention-ngram: phosphorylates and inhibitst.e2: ents2Label-mention-ngram: SHARED activatedte1: ents2Label-mention-ngram: (tWe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='acetylation'] Acetylationt:e1: ents2Label-mention-ngram: promoting SHARED acetylationt#e2: args2Role-mention-ngram: kinaset#e2: args2Role-mention-ngram: AMPK )t.e2: ents2Label-mention-ngram: protein kinase (t[e2: trigger-arg-path: promoting:Positive_regulation >dobj [lemma='acetylation'] Acetylationtfe2: trigger-arg-path: promoting:Positive_regulation >dobj [lemma='acetylation'] controlled:Acetylationtae2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj Simple_chemicaltNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='amp'] Simple_chemicalt6e1: ents2Label-mention-ngram: ( GENE_OR_GENE_PRODUCT )t/e1: ents2Label-mention-ngram: deacetylase SIRT1tme2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='amp'] controllert.e2: ents2Label-mention-ngram: ) phosphorylatest.e2: args2Role-mention-ngram: activated proteintZe2: trigger-arg-path: promoting:Positive_regulation >dobj [lemma='acetylation'] controlledt/e1: ents2Label-mention-ngram: SIRT1 , promotingt9e1: args2Role-mention-ngram: CONTROLLER activated proteintce2: trigger-arg-path: Positive_regulation nsubj [lemma='amp'] controllerte2: ents2Label-mention-ngram: (t3e2: args2Role-mention-ngram: , promoting CONTROLLEDt&e1: args2Role-mention-ngram: activatedtXe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Simple_chemicaltUe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='amp'] Simple_chemicalt*e1: ents2Label-mention-ngram: and inhibitstce1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='amp'] controller:Simple_chemicalt,e2: args2Role-mention-ngram: p53 deacetylaset/e2: args2Role-mention-ngram: phosphorylates andt"e2: args2Role-mention-ngram: SIRT1tye2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='amp'] controller:Simple_chemicaltGe2: trigger-arg-path: promoting >dobj [lemma='acetylation'] AcetylationtQe2: trigger-arg-path: promoting:Positive_regulation nsubj Simple_chemicalt*e2: ents2Label-mention-ngram: and inhibitst0e1: args2Role-mention-ngram: kinase ( CONTROLLEDtRe2: trigger-arg-path: Positive_regulation nsubj controller:Simple_chemicalt=e2: trigger-arg-path: promoting nsubj Simple_chemicaltUe1: trigger-arg-path: activated:Positive_regulation >nsubj controller:Simple_chemicaltPe2: trigger-arg-path: Positive_regulation >dobj [lemma='acetylation'] controlledt#e2: ents2Label-mention-ngram: SIRT1tse2: trigger-arg-path: Positive_regulation nsubj [lemma='amp'] controller:Simple_chemicalt4e1: ents2Label-mention-ngram: the SHARED deacetylaset%e2: ents2Label-mention-ngram: proteint.e2: args2Role-mention-ngram: deacetylase SIRT1t&e2: ents2Label-mention-ngram: ( AMPK )tfe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj controller:Simple_chemicalt0e2: args2Role-mention-ngram: deacetylase SIRT1 ,t%e2: ents2Label-mention-ngram: the p53t4e1: ents2Label-mention-ngram: ( GENE_OR_GENE_PRODUCTtIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='amp'] controllertVe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj controllert.e2: args2Role-mention-ngram: SIRT1 , promotingt/e2: ents2Label-mention-ngram: activated proteint,e1: ents2Label-mention-ngram: protein kinaset-e2: args2Role-mention-ngram: ) phosphorylatest.e2: ents2Label-mention-ngram: inhibits the p53tMe2: trigger-arg-path: lemmatizedTrigger=promote nsubj Simple_chemicaltte1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj [lemma='amp'] controller:Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controller:Simple_chemicalte1: args2Role-mention-ngram: (t&e2: args2Role-mention-ngram: promotingt0e1: ents2Label-mention-ngram: , promoting SHAREDt6e1: ents2Label-mention-ngram: activated protein kinaset.e1: args2Role-mention-ngram: activated proteint.e1: ents2Label-mention-ngram: ) phosphorylatest.e1: ents2Label-mention-ngram: promoting SHAREDt)e2: ents2Label-mention-ngram: deacetylaset'e2: ents2Label-mention-ngram: promotingt$e1: args2Role-mention-ngram: proteintVe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='acetylation'] controlledtPe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='amp'] controllert2e2: args2Role-mention-ngram: AMPK ) phosphorylatest?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='amp'] controller:Simple_chemicalt)e2: ents2Label-mention-ngram: , promotingt1e2: ents2Label-mention-ngram: the p53 deacetylasetme2: trigger-arg-path: binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttge2: trigger-arg-path: binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] Gene_or_gene_producttinterceding-token ngrams: in antXe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] themetXe2: trigger-arg-path: Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] themetne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='AMPK'] controller:Gene_or_gene_producttme2: trigger-arg-path: Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj [lemma='Raptor'] >prep_in [lemma='manner'] >vmod [lemma='lead'] >prep_to [lemma='binding'] e2:binding:Bindingt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='AMPK'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] themet?shortest-path: dobj [lemma='Raptor'] >prep_in [lemma='manner'] >vmod [lemma='lead'] >prep_to [lemma='binding']totrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj >prep_in >vmod >prep_to e2:binding:BindingtZe1: trigger-arg-path: phosphorylates >nsubj [lemma='AMPK'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT totinterceding-token ngrams: LKB1t+interceding-token ngrams: an LKB1 dependenttSe2: trigger-arg-path: binding >prep_of [lemma='protein'] theme:Gene_or_gene_producttOe1: trigger-arg-path: phosphorylates >nsubj [lemma='AMPK'] Gene_or_gene_productt`e2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] themet!interceding-token ngrams: an LKB1tFe2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] themet+interceding-token ngrams: manner leading totoe2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] Gene_or_gene_producttMe2: trigger-arg-path: binding >prep_of [lemma='protein'] Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='AMPK'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='AMPK'] controllert(interceding-token ngrams: LKB1 dependenttUe2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] Gene_or_gene_productt3shortest-path: dobj >prep_in >vmod >prep_tot=e2: ents2Label-mention-ngram: binding of GENE_OR_GENE_PRODUCTtprep_of [lemma='protein'] >prep_to [lemma='Raptor'] themetMe2: trigger-arg-path: Binding >prep_of [lemma='protein'] Gene_or_gene_productt$interceding-token ngrams: in an LKB1tSe2: trigger-arg-path: Binding >prep_of [lemma='protein'] theme:Gene_or_gene_productt5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT totme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='AMPK'] controllertYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='AMPK'] controllert(interceding-token ngrams: leading to thet2interceding-token ngrams: dependent manner leadingtue2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttXe2: trigger-arg-path: binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] themet_e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='AMPK'] Gene_or_gene_productt>e2: trigger-arg-path: binding >prep_of [lemma='protein'] themetHinterceding-tokens-full-span: in an LKB1 dependent manner leading to thet(interceding-token ngrams: manner leadingt[e2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] theme:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='AMPK'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='AMPK'] controller:Gene_or_gene_producttge2: trigger-arg-path: Binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] Gene_or_gene_productt/interceding-token ngrams: LKB1 dependent mannert>e2: trigger-arg-path: Binding >prep_of [lemma='protein'] themetce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='AMPK'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='AMPK'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] Gene_or_gene_producttEe1: trigger-arg-path: phosphorylates >nsubj [lemma='AMPK'] controllertje2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] >prep_to [lemma='Raptor'] themetJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='AMPK'] controllertLe1: trigger-arg-path: bound:Binding >ccomp >nsubj theme:Gene_or_gene_productt@e1: trigger-arg-path: Binding >ccomp >nsubj Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf1'] Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rra'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rra'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='rra'] Gene_or_gene_producttTe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rra'] theme:Gene_or_gene_producttie1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] theme:Gene_or_gene_producttce1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME boundtMe2: trigger-arg-path: Binding >nsubj [lemma='rra'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: bound SHAREDt.e1: args2Role-mention-ngram: THEME bound THEMEtFe1: trigger-arg-path: bound:Binding >ccomp >nsubj Gene_or_gene_productt(e1: args2Role-mention-ngram: bound THEMEtEe1: trigger-arg-path: bound >nsubj [lemma='gtp'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf1'] themet?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf1'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rra'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='gtp'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rra'] Gene_or_gene_producttAe2: trigger-arg-path: binds:Binding >prep_to [lemma='raf1'] themet8e1: trigger-arg-path: Binding >nsubj [lemma='gtp'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj Gene_or_gene_producttae1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rra'] theme:Gene_or_gene_productt/e1: trigger-arg-path: bound >ccomp >nsubj themet;e2: ents2Label-mention-ngram: binds to GENE_OR_GENE_PRODUCTtee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj Gene_or_gene_productt>e1: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] themet>e2: trigger-arg-path: binds:Binding >nsubj [lemma='rra'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf1'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf1'] themetDe1: trigger-arg-path: bound >ccomp >nsubj theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf1'] theme:Gene_or_gene_productte1: trigger: boundtVe2: trigger-arg-path: binds:Binding >prep_to [lemma='raf1'] theme:Gene_or_gene_productt1e1: trigger-arg-path: Binding >ccomp >nsubj themetKe2: trigger-arg-path: binds >nsubj [lemma='rra'] theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rra'] themetMe1: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >nsubj [lemma='rra'] theme:Gene_or_gene_producttOshortest-path: ccomp [lemma='bind'] >nsubj [lemma='rra']tPe2: trigger-arg-path: binds:Binding >prep_to [lemma='raf1'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] theme:Gene_or_gene_producttKe1: trigger-arg-path: bound >nsubj [lemma='gtp'] theme:Gene_or_gene_producttce1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] Gene_or_gene_productt]e1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rra'] themet6e1: trigger-arg-path: bound >nsubj [lemma='gtp'] themetLe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rra'] themet[e1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rra'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='rra'] themet0e1: trigger-arg-path: bound:Binding >nsubj themet7e1: trigger-arg-path: bound:Binding >ccomp >nsubj themetGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] themet@e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj themetGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rra'] themetHe2: trigger-arg-path: binds >prep_to [lemma='raf1'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rra'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] themet9e2: trigger-arg-path: binds >prep_to [lemma='raf1'] themetPtrigger-to-trigger-path: e1:bound:Binding >ccomp [lemma='bind'] e2:binds:Bindingtle1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rra'] Gene_or_gene_productt7e1: trigger-arg-path: bound >nsubj Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='rra'] Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='rra'] themet\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding >ccomp >nsubj theme:Gene_or_gene_productt=e1: trigger-arg-path: bound >nsubj theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_to [lemma='raf1'] theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: boundt"e1: args2Role-mention-ngram: boundt(e1: trigger-arg-path: bound >nsubj themetEe1: trigger-arg-path: bound:Binding >nsubj theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >prep_to [lemma='raf1'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj themetEe2: trigger-arg-path: binds >nsubj [lemma='rra'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_producttNe2: trigger-arg-path: binds >prep_to [lemma='raf1'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT boundt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] Gene_or_gene_productt>e1: trigger-arg-path: bound >ccomp >nsubj Gene_or_gene_producttAtrigger-to-trigger-path: e1:bound:Binding >ccomp e2:binds:BindingtUe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_to [lemma='raf1'] Gene_or_gene_productt"e2: args2Role-mention-ngram: Smad3t"e2: ents2Label-mention-ngram: thentre2: trigger-arg-path: interact:Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] theme:Gene_or_gene_producttHe2: trigger-arg-path: interact:Binding nsubj controller:Simple_chemicaltRe2: trigger-arg-path: lemmatizedTrigger=interact prep_with >nn Gene_or_gene_producttCe2: trigger-arg-path: interact:Binding prep_with >nn themetUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rus'] controllertPe2: trigger-arg-path: interact prep_with [lemma='protein'] >nn [lemma='smad4'] theme:Gene_or_gene_productt_trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj >rcmod e2:interact:BindingtZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubj [lemma='rus'] controller:Simple_chemicalt2e2: trigger-arg-path: Binding >prep_with >nn themetLe2: trigger-arg-path: lemmatizedTrigger=interact prep_with >nn theme:Gene_or_gene_producttJe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL phosphorylates intracellulartve2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='protein'] >nn [lemma='smad4'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with >nn Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] Gene_or_gene_productt@e2: trigger-arg-path: interact nsubj [lemma='rus'] Simple_chemicaltshortest-path: dobjt'e2: ents2Label-mention-ngram: and Smad3t,e2: args2Role-mention-ngram: THEME and Smad3tJe2: trigger-arg-path: interact:Binding >prep_with >nn Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rus'] controller:Simple_chemicaltZe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with >nn theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: , which thentDe1: trigger-arg-path: phosphorylates >nsubj [lemma='rus'] controllertCshortest-path: dobj [lemma='smad2']tle2: trigger-arg-path: interact:Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] Gene_or_gene_producttUe2: trigger-arg-path: interact >prep_with [lemma='protein'] >nn [lemma='smad4'] themetNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rus'] Simple_chemicalt2e1: args2Role-mention-ngram: CONTROLLER CONTROLLEDtbe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with >nn theme:Gene_or_gene_producttie2: trigger-arg-path: Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: then interactt+e1: ents2Label-mention-ngram: intracellulart;e1: trigger-arg-path: phosphorylates >nsubj Simple_chemicalt;e2: trigger-arg-path: interact prep_with [lemma='protein'] >nn [lemma='smad4'] themetXe2: trigger-arg-path: interact:Binding nsubj controller:Simple_chemicaltie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rus'] controllert?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] theme:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=interact prep_with [lemma='protein'] >nn [lemma='smad4'] themet*e2: args2Role-mention-ngram: Smad3 , whicht!e2: args2Role-mention-ngram: thent+e2: ents2Label-mention-ngram: then interactt0e2: args2Role-mention-ngram: which then interactt?e2: trigger-arg-path: Binding nsubj controller:Simple_chemicalt\e2: trigger-arg-path: lemmatizedTrigger=interact prep_with >nn themetIe2: trigger-arg-path: Binding prep_with >nn Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj Simple_chemicalt*e2: trigger-arg-path: Binding nsubj [lemma='rus'] controller:Simple_chemicalt=e2: trigger-arg-path: lemmatizedTrigger=interact nsubj [lemma='rus'] controllert|e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='protein'] >nn [lemma='smad4'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: then interact withtAe1: ents2Label-mention-ngram: phosphorylates intracellular SHAREDtee1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rus'] controller:Simple_chemicaltJe2: trigger-arg-path: interact nsubj [lemma='rus'] Simple_chemicalt]e2: trigger-arg-path: interact:Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] themetge2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='protein'] >nn [lemma='smad4'] themetGe2: trigger-arg-path: Binding >prep_with >nn theme:Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rus'] controllertje2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubj [lemma='rus'] Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with >nn Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj [lemma='smad2'] >rcmod [lemma='interact'] e2:interact:Bindingtde2: trigger-arg-path: interact >prep_with [lemma='protein'] >nn [lemma='smad4'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj controller:Simple_chemicalt(e2: args2Role-mention-ngram: and Smad3 ,t2e1: ents2Label-mention-ngram: intracellular SHAREDtOe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj Simple_chemicaltRe2: trigger-arg-path: interact:Binding prep_with >nn theme:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with >nn themetLe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj Simple_chemicaltOe2: trigger-arg-path: Binding prep_with >nn themetZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rus'] Simple_chemicaltce2: trigger-arg-path: Binding >prep_with [lemma='protein'] >nn [lemma='smad4'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: phosphorylates intracellulartTe1: trigger-arg-path: phosphorylates >nsubj [lemma='rus'] controller:Simple_chemicalt+e2: trigger-arg-path: interact prep_by [lemma='sirna'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=suppression >poss [lemma='its'] controlledtie1: trigger-arg-path: Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlledt>e2: trigger-arg-path: Negative_activation >poss Generic_entitytetrigger-to-trigger-path: e1:induction:Negative_activation >prep_of e2:suppression:Negative_activationtNe1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >prep_by controllert,e1: args2Role-mention-ngram: its suppressiontEe2: trigger-arg-path: suppression >prep_by [lemma='sirna'] controllert*e1: args2Role-mention-ngram: expression byt[e2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by controllert.e1: ents2Label-mention-ngram: by TGF-beta1 andt?e2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by [lemma='sirna'] controller:Gene_or_gene_producttLe1: trigger-arg-path: induction >prep_of >nn controlled:Gene_or_gene_productt}e1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] Gene_or_gene_producttprep_of >prep_by controllertWe2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by [lemma='sirna'] controllert(e1: args2Role-mention-ngram: suppressiont`e1: trigger-arg-path: induction:Negative_activation >prep_of >nn controlled:Gene_or_gene_producttAe1: trigger-arg-path: induction >prep_of >nn Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by [lemma='sirna'] controllertpe2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by controller:Gene_or_gene_productt6e2: trigger-arg-path: suppression >poss Generic_entityt?e2: trigger-arg-path: suppression >prep_by Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss [lemma='its'] controlledt*e1: args2Role-mention-ngram: TGF-beta1 andt?e1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controller:Gene_or_gene_producttie1: trigger-arg-path: induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] Gene_or_gene_producttPe1: trigger-arg-path: Negative_activation >prep_of >prep_by Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >nn controlledt^e2: trigger-arg-path: suppression:Negative_activation >prep_by controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: TGF-beta1tve1: trigger-arg-path: Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] Gene_or_gene_productt=e2: trigger-arg-path: Negative_activation >prep_by controllertPe1: trigger-arg-path: induction:Negative_activation >prep_of >prep_by controllertXe2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss controlledtue2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by [lemma='sirna'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >nn controlled:Gene_or_gene_producttGe2: trigger-arg-path: Negative_activation >prep_by Gene_or_gene_producttFe1: trigger-arg-path: induction >prep_of >prep_by Gene_or_gene_productt+e2: args2Role-mention-ngram: suppression byt*e1: ents2Label-mention-ngram: by TGF-beta1t~e1: trigger-arg-path: Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlled:Gene_or_gene_productte1: trigger: inductiont,e2: ents2Label-mention-ngram: suppression bytce1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >prep_by controller:Gene_or_gene_productt@e2: trigger-arg-path: suppression >poss [lemma='its'] controlledt2e2: trigger-arg-path: suppression >poss controlledtAe1: trigger-arg-path: Negative_activation >prep_of >nn controlledtDe2: trigger-arg-path: lemmatizedTrigger=suppression >poss controlledt7e1: trigger-arg-path: induction >prep_of >nn controlledt{e1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlled:Gene_or_gene_productt.e1: args2Role-mention-ngram: TGF-beta1 and itst3e2: ents2Label-mention-ngram: SHARED suppression bytDe2: trigger-arg-path: suppression >poss [lemma='its'] Generic_entityt*e1: ents2Label-mention-ngram: induction oftee2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >prep_by Gene_or_gene_productt_e1: trigger-arg-path: induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlledt\e2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by controller:Gene_or_gene_producttOe2: trigger-arg-path: suppression >poss [lemma='its'] controlled:Generic_entityt'e1: ents2Label-mention-ngram: TGF-beta1tte1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controllertIe2: trigger-arg-path: suppression:Negative_activation >prep_by controllertae2: trigger-arg-path: lemmatizedTrigger=suppression >poss [lemma='its'] controlled:Generic_entitytFe1: trigger-arg-path: Negative_activation >prep_of >prep_by controllertXe2: trigger-arg-path: suppression:Negative_activation >poss [lemma='its'] Generic_entitytMe2: trigger-arg-path: Negative_activation >prep_by [lemma='sirna'] controllertGe2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by controllertUe2: trigger-arg-path: suppression:Negative_activation >poss controlled:Generic_entityt-e1: args2Role-mention-ngram: by TGF-beta1 andtUe1: trigger-arg-path: induction:Negative_activation >prep_of >nn Gene_or_gene_productt5e2: trigger-arg-path: suppression >prep_by controllertse1: trigger-arg-path: Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED expressiont0e1: ents2Label-mention-ngram: its suppression bytFe2: trigger-arg-path: suppression:Negative_activation >poss controlledt$e1: args2Role-mention-ngram: and itst&e1: args2Role-mention-ngram: inductiontbe2: trigger-arg-path: Negative_activation >prep_by [lemma='sirna'] controller:Gene_or_gene_producttSe2: trigger-arg-path: suppression:Negative_activation >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controllert?e1: trigger-arg-path: Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controller:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >nn controlledt?e1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] Gene_or_gene_productt/e1: args2Role-mention-ngram: its suppression byt{trigger-to-trigger-path: e1:induction:Negative_activation >prep_of [lemma='suppression'] e2:suppression:Negative_activationtbe1: trigger-arg-path: induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controllertle1: trigger-arg-path: Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controllertXe1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >prep_by Gene_or_gene_producttRe2: trigger-arg-path: Negative_activation >prep_by controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >nn controlled:Gene_or_gene_producttHe2: trigger-arg-path: Negative_activation >poss [lemma='its'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlled:Gene_or_gene_productt/e1: ents2Label-mention-ngram: TGF-beta1 and itstJe2: trigger-arg-path: suppression >prep_by controller:Gene_or_gene_producttee1: trigger-arg-path: induction:Negative_activation >prep_of >prep_by controller:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >prep_by controllertte1: trigger-arg-path: induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controller:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=suppression >poss Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] Gene_or_gene_productt+e1: args2Role-mention-ngram: suppression bytwe1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >prep_by controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLED suppressiont)e2: ents2Label-mention-ngram: suppressiontQe1: trigger-arg-path: induction >prep_of >prep_by controller:Gene_or_gene_producttOe2: trigger-arg-path: suppression >prep_by [lemma='sirna'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: by SHAREDtae2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by [lemma='sirna'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: and itst-e1: ents2Label-mention-ngram: its suppressiont2e1: args2Role-mention-ngram: CONTROLLED expressiont+e1: ents2Label-mention-ngram: expression bytle2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by [lemma='sirna'] controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] Gene_or_gene_producttYe2: trigger-arg-path: suppression:Negative_activation >prep_by [lemma='sirna'] controllert\e2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss Generic_entityt:e2: trigger-arg-path: Negative_activation >poss controlledtne2: trigger-arg-path: suppression:Negative_activation >prep_by [lemma='sirna'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss [lemma='its'] Generic_entitytce2: trigger-arg-path: suppression:Negative_activation >poss [lemma='its'] controlled:Generic_entityt5e1: ents2Label-mention-ngram: expression by TGF-beta1t1e1: ents2Label-mention-ngram: and its suppressiont5e1: args2Role-mention-ngram: CONTROLLED expression byt4e1: args2Role-mention-ngram: induction of CONTROLLEDtWe2: trigger-arg-path: Negative_activation >poss [lemma='its'] controlled:Generic_entityt1e1: ents2Label-mention-ngram: induction of SHAREDt6e1: args2Role-mention-ngram: suppression by CONTROLLERt'e1: ents2Label-mention-ngram: inductiont+e1: ents2Label-mention-ngram: TGF-beta1 andtVe2: trigger-arg-path: lemmatizedTrigger=suppression >poss [lemma='its'] Generic_entityte2: trigger: suppressiont2e1: ents2Label-mention-ngram: SHARED expression bytLe2: trigger-arg-path: Negative_activation >poss [lemma='its'] Generic_entityt=e1-label: Negative_activation + e2-label: Negative_activationtKe1: trigger-arg-path: induction:Negative_activation >prep_of >nn controlledtJe2: trigger-arg-path: suppression:Negative_activation >poss Generic_entitytVe1: trigger-arg-path: Negative_activation >prep_of >nn controlled:Gene_or_gene_producttwe1: trigger-arg-path: induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controller:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlledtIe2: trigger-arg-path: Negative_activation >poss controlled:Generic_entityt?e1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: expressiontSe1: trigger-arg-path: lemmatizedTrigger=induction >prep_of >nn Gene_or_gene_producttTe2: trigger-arg-path: suppression:Negative_activation >poss [lemma='its'] controlledtge2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss controlled:Generic_entityt6e2: args2Role-mention-ngram: CONTROLLED suppression byt(e2: args2Role-mention-ngram: suppressiontZe1: trigger-arg-path: induction:Negative_activation >prep_of >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlledtue2: trigger-arg-path: lemmatizedTrigger=suppression:Negative_activation >poss [lemma='its'] controlled:Generic_entityt)e1: ents2Label-mention-ngram: suppressiontQe2: trigger-arg-path: lemmatizedTrigger=suppression >prep_by Gene_or_gene_productt2e1: ents2Label-mention-ngram: of SHARED expressiont(e1: ents2Label-mention-ngram: expressiont,e1: ents2Label-mention-ngram: suppression bytse1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='expression'] >nn [lemma='alphasma'] controlledtle1: trigger-arg-path: induction >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of >nn Gene_or_gene_productt5e1: args2Role-mention-ngram: of CONTROLLED expressiont)e1: args2Role-mention-ngram: by TGF-beta1tAe2: trigger-arg-path: suppression >poss controlled:Generic_entityt[e1: trigger-arg-path: Negative_activation >prep_of >prep_by controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: SHARED suppressiontZe2: trigger-arg-path: suppression >prep_by [lemma='sirna'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: and its suppressiont4e1: args2Role-mention-ngram: expression by TGF-beta1t?e1: trigger-arg-path: lemmatizedTrigger=induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controller:Gene_or_gene_producttce2: trigger-arg-path: suppression:Negative_activation >prep_by [lemma='sirna'] Gene_or_gene_producttKe1: trigger-arg-path: Negative_activation >prep_of >nn Gene_or_gene_productt6e2: args2Role-mention-ngram: suppression by CONTROLLERtve1: trigger-arg-path: induction:Negative_activation >prep_of [lemma='suppression'] >prep_by [lemma='sirna'] controllertSe2: trigger-arg-path: lemmatizedTrigger=suppression >poss controlled:Generic_entitytge2: trigger-arg-path: Positive_regulation prep_by [lemma='cyclinb'] controllertfe2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by controller:Gene_or_gene_producttntrigger-to-trigger-path: e1:induces:Positive_regulation >prepc_by >dobj e2:phosphorylation:Positive_regulationt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by Gene_or_gene_productt'e1: args2Role-mention-ngram: fission bytue2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='cyclinb'] controllertme2: trigger-arg-path: phosphorylation prep_by [lemma='cyclinb'] Gene_or_gene_productthe2: trigger-arg-path: phosphorylation:Positive_regulation prep_by controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: phosphorylation of thetXe1: trigger-arg-path: induces:Positive_regulation >nsubj controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: GTPase SHARED byt8e1: ents2Label-mention-ngram: also induces mitochondrialtqe2: trigger-arg-path: Positive_regulation prep_by [lemma='cyclinb'] Gene_or_gene_productt1e1: args2Role-mention-ngram: fission by promotingtfe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ralbp1'] controller:Gene_or_gene_producttCe1: trigger-arg-path: induces:Positive_regulation >nsubj controllert&e1: args2Role-mention-ngram: promotingt.e2: ents2Label-mention-ngram: SHARED by SHAREDt+e1: ents2Label-mention-ngram: mitochondrialt(e1: ents2Label-mention-ngram: fission bytoe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ralbp1'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: the GTPase SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] controllertie1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:Gene_or_gene_producttMe1: trigger-arg-path: induces:Positive_regulation >nsubj Gene_or_gene_productt*e1: ents2Label-mention-ngram: also inducest2e1: args2Role-mention-ngram: induces mitochondrialt@e1: trigger-arg-path: induces >nsubj [lemma='ralbp1'] controllert*e1: ents2Label-mention-ngram: by promotingt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] controller:Gene_or_gene_producttwe2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] controllert*e1: args2Role-mention-ngram: promoting thet-e1: args2Role-mention-ngram: by promoting thet;e1: ents2Label-mention-ngram: induces mitochondrial fissiont?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also inducest$e1: args2Role-mention-ngram: fissiont2e1: args2Role-mention-ngram: mitochondrial fissiontTe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ralbp1'] controllertJe1: trigger-arg-path: induces >nsubj [lemma='ralbp1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: the CONTROLLEDtIe2: trigger-arg-path: phosphorylation prep_by Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: induces mitochondrialt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:induces:Positive_regulation >prepc_by [lemma='promote'] >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='cyclinb'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: GTPaset6e1: ents2Label-mention-ngram: mitochondrial fission byt3e1: ents2Label-mention-ngram: mitochondrial fissiontie1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ralbp1'] controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: the GTPaset$e2: ents2Label-mention-ngram: GTPaset+e2: ents2Label-mention-ngram: GTPase SHAREDt.e1: ents2Label-mention-ngram: SHARED by SHAREDt4e1: ents2Label-mention-ngram: the phosphorylation oftQe2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by controllertxe2: trigger-arg-path: phosphorylation prep_by [lemma='cyclinb'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: phosphorylation of thet|e2: trigger-arg-path: Positive_regulation prep_by [lemma='cyclinb'] controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ralbp1'] controllert5e1: args2Role-mention-ngram: mitochondrial fission byt%e1: ents2Label-mention-ngram: fissiontze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ralbp1'] controller:Gene_or_gene_producttbshortest-path: prepc_by [lemma='promote'] >dobj [lemma='phosphorylation']t^e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >nsubj [lemma='ralbp1'] controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ralbp1'] Gene_or_gene_productt*e1: args2Role-mention-ngram: mitochondrialt:e1: args2Role-mention-ngram: induces mitochondrial fissiont(e1: ents2Label-mention-ngram: the GTPaset;e1: ents2Label-mention-ngram: promoting the phosphorylationtoe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='cyclinb'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: the GTPase SHAREDtTe2: trigger-arg-path: phosphorylation prep_by controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: of the GTPaset)e1: args2Role-mention-ngram: also inducest%shortest-path: prepc_by >dobjt4e1: args2Role-mention-ngram: CONTROLLER also inducestUe1: trigger-arg-path: induces >nsubj [lemma='ralbp1'] controller:Gene_or_gene_producttSe2: trigger-arg-path: phosphorylation:Positive_regulation prep_by controllert+e1: ents2Label-mention-ngram: GTPase SHAREDt1e1: ents2Label-mention-ngram: the phosphorylationt5e1: args2Role-mention-ngram: promoting the CONTROLLEDtee1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ralbp1'] controllertee2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by controllerte2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='cyclinb'] Gene_or_gene_productt]e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by Gene_or_gene_productt+e1: ents2Label-mention-ngram: promoting thet?e2: trigger-arg-path: phosphorylation prep_by controllert7e1: args2Role-mention-ngram: also induces mitochondrialt^e1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ralbp1'] Gene_or_gene_producttCe2: trigger-arg-path: Positive_regulation prep_by controllert.e2: ents2Label-mention-ngram: GTPase SHARED bytXe2: trigger-arg-path: Positive_regulation prep_by controller:Gene_or_gene_producttce2: trigger-arg-path: phosphorylation prep_by [lemma='cyclinb'] controllertVe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ralbp1'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: fission by promotingt+e1: ents2Label-mention-ngram: of the GTPasetLe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ralbp1'] controllert)e1: args2Role-mention-ngram: by promotingt.e1: ents2Label-mention-ngram: by promoting thetMe2: trigger-arg-path: Positive_regulation prep_by Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='z36'] controller:Gene_or_gene_producttTtrigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj e2:interaction:Bindingt9e1: trigger-arg-path: inhibit >nsubj Gene_or_gene_productt$e1: args2Role-mention-ngram: inhibittXe1: trigger-arg-path: inhibit:Negative_regulation >nsubj controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='z36'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: the interactiont2e1: args2Role-mention-ngram: competitively inhibittDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can competitivelyt/e1: trigger-arg-path: inhibit >nsubj controllert%e1: ents2Label-mention-ngram: inhibitt3e1: ents2Label-mention-ngram: competitively inhibittCe1: trigger-arg-path: inhibit:Negative_regulation >nsubj controllert5e1: ents2Label-mention-ngram: inhibit the interactiont9e1: args2Role-mention-ngram: CONTROLLER can competitivelyt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='z36'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: inhibit the CONTROLLEDt6e1: args2Role-mention-ngram: competitively inhibit thet+e1: ents2Label-mention-ngram: competitivelytOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='z36'] controllert=e1: trigger-arg-path: inhibit >nsubj [lemma='z36'] controllert8e1: ents2Label-mention-ngram: interaction between SHAREDtjtrigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj [lemma='interaction'] e2:interaction:Bindingt7e1: ents2Label-mention-ngram: can competitively inhibitt.e1: args2Role-mention-ngram: can competitivelytQe1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='z36'] controllert)e1: ents2Label-mention-ngram: inhibit thetGe1: trigger-arg-path: inhibit >nsubj [lemma='z36'] Gene_or_gene_producttCshortest-path: dobj [lemma='interaction']t5e1: ents2Label-mention-ngram: the interaction betweent[e1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='z36'] Gene_or_gene_productte1: trigger: inhibittRe1: trigger-arg-path: inhibit >nsubj [lemma='z36'] controller:Gene_or_gene_producttMe1: trigger-arg-path: inhibit:Negative_regulation >nsubj Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='z36'] Gene_or_gene_producttfe1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='z36'] controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: interaction between SHAREDt(e1: args2Role-mention-ngram: inhibit thet*e1: args2Role-mention-ngram: competitivelyt7e1: ents2Label-mention-ngram: competitively inhibit thet/e1: ents2Label-mention-ngram: can competitivelyt6e1: args2Role-mention-ngram: can competitively inhibittIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='z36'] controllertSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='z36'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='z36'] Gene_or_gene_producttDe1: trigger-arg-path: inhibit >nsubj controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='z36'] controllertme1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='akt'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='akt'] controller:Gene_or_gene_productt`e1: trigger-arg-path: Positive_regulation >prep_by [lemma='akt'] controller:Gene_or_gene_producttQe1: trigger-arg-path: phosphorylation >prep_by [lemma='akt'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='tsc1'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] themet#interceding-token ngrams: repressestGe1: trigger-arg-path: phosphorylation >prep_by [lemma='akt'] controllert&interceding-token ngrams: GAP activitytSe2: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] theme:Gene_or_gene_productthtrigger-to-trigger-path: e1:phosphorylation:Positive_regulation dobj >prep_of e2:complex:BindingtUe1: trigger-arg-path: Positive_regulation >prep_by [lemma='akt'] Gene_or_gene_producttKe1: trigger-arg-path: Positive_regulation >prep_by [lemma='akt'] controllertee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] theme:Gene_or_gene_productt[e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='akt'] controllertHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] themet6e2: trigger-arg-path: complex >nn [lemma='tsc2'] themetEe2: trigger-arg-path: complex >nn [lemma='tsc2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='tsc1'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='tsc1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] theme:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] themetKe2: trigger-arg-path: complex >nn [lemma='tsc2'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='tsc2'] theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='tsc1'] themet)interceding-token ngrams: activity of thetYe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='akt'] controllertEe1: ents2Label-mention-ngram: phosphorylation by GENE_OR_GENE_PRODUCTtpe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='akt'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='akt'] controller:Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='tsc2'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] themet0interceding-token ngrams: represses GAP activityt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and SHAREDtce1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='akt'] Gene_or_gene_productt)interceding-token ngrams: GAP activity oft,shortest-path: dobj >prep_of >nntEe2: trigger-arg-path: complex >nn [lemma='tsc1'] Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='tsc1'] themet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] theme:Gene_or_gene_productt'interceding-token ngrams: represses GAPt\e1: trigger-arg-path: phosphorylation >prep_by [lemma='akt'] controller:Gene_or_gene_productt;interceding-tokens-full-span: represses GAP activity of thet?shortest-path: dobj [lemma='activity'] >prep_of [lemma='complex'] >nn [lemma='tsc1']t]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] themetee1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='akt'] Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylation:Positive_regulation dobj [lemma='activity'] >prep_of [lemma='complex'] e2:complex:Bindingtwe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='akt'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='tsc2'] themet_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] Gene_or_gene_productt1e2: args2Role-mention-ngram: interacts with THEMEtUe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] theme:Familyt"interceding-token ngrams: mutationtbe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='itsn1'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='itsn1'] themetVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] themetushortest-path: ccomp [lemma='interact'] >nsubj [lemma='itsn1']t8e2: trigger-arg-path: interacts:Binding >prep_with themet%interceding-token ngrams: the findingtCe1: trigger-arg-path: interaction >prep_with [lemma='ras17n'] themet3e1: args2Role-mention-ngram: THEME interaction witht2e1: trigger-arg-path: interaction >prep_with themetGe1: trigger-arg-path: interaction >prep_with theme:Gene_or_gene_productt>e2: trigger-arg-path: interacts >prep_with [lemma='ra'] Familyt$interceding-token ngrams: reduced byt=e2: trigger-arg-path: interacts >prep_with [lemma='ra'] themet&interceding-token ngrams: finding thatt$interceding-token ngrams: by the 69Ntde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='itsn1'] Gene_or_gene_producttEe2: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] themet]e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] theme:Familyt1interceding-token ngrams: dramatically reduced bytCe1: trigger-arg-path: interaction:Binding >nn [lemma='itsn1'] themet+shortest-path: ccomp >nsubjtCe1: ents2Label-mention-ngram: interaction with GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: Binding >prep_with [lemma='ras17n'] themet*interceding-token ngrams: with the findingtFe2: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] Familyt&interceding-token ngrams: dramaticallytSe2: trigger-arg-path: interacts:Binding >nsubj [lemma='itsn1'] Gene_or_gene_productt-interceding-token ngrams: mutation consistentt[e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with Gene_or_gene_productt1interceding-token ngrams: 69N mutation consistenttnsubj [lemma='itsn1'] themet-interceding-token ngrams: consistent with thetUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ras17n'] themet.e1: ents2Label-mention-ngram: interaction witht]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ras17n'] themet`e1: trigger-arg-path: interaction:Binding >prep_with [lemma='ras17n'] theme:Gene_or_gene_productt*interceding-token ngrams: the finding thattle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ras17n'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='itsn1'] themetde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='itsn1'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] FamilytRe1: trigger-arg-path: interaction >prep_with [lemma='ras17n'] Gene_or_gene_producttKe2: trigger-arg-path: interacts >nsubj [lemma='itsn1'] Gene_or_gene_productt(interceding-token ngrams: reduced by thetre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ras17n'] theme:Gene_or_gene_productt)interceding-token ngrams: consistent withtNe1: trigger-arg-path: Binding >prep_with [lemma='ras17n'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_with [lemma='ras17n'] theme:Gene_or_gene_productt7e2: trigger-arg-path: interacts >prep_with theme:FamilytDe2: trigger-arg-path: interacts >prep_with [lemma='ra'] theme:Familytbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='itsn1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttDe2: trigger-arg-path: interacts:Binding >nsubj [lemma='itsn1'] themet!interceding-token ngrams: reducedt"interceding-token ngrams: with thet3e1: args2Role-mention-ngram: interaction with THEMEtMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='itsn1'] themetOe1: trigger-arg-path: interaction:Binding >prep_with theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with FamilytYe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with themetQe2: trigger-arg-path: interacts >nsubj [lemma='itsn1'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with theme:Familyt;e1: trigger-arg-path: interaction >nn [lemma='itsn1'] themet!interceding-token ngrams: the 69Nt-e1: args2Role-mention-ngram: interaction withtXe1: trigger-arg-path: interaction >prep_with [lemma='ras17n'] theme:Gene_or_gene_productt interceding-token ngrams: by thet2interceding-token ngrams: was dramatically reducedt\e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='itsn1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='itsn1'] themetWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] Familyt\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='itsn1'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='itsn1'] Gene_or_gene_productt$interceding-token ngrams: consistenttPe1: trigger-arg-path: interaction >nn [lemma='itsn1'] theme:Gene_or_gene_producttLe2: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] theme:Familytae1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with theme:Gene_or_gene_productt0e2: trigger-arg-path: interacts >prep_with themetKe1: trigger-arg-path: interaction:Binding >prep_with [lemma='ras17n'] themet3e2: ents2Label-mention-ngram: interacts with FAMILYtFe1: trigger-arg-path: Binding >nn [lemma='itsn1'] Gene_or_gene_productt9e2: trigger-arg-path: interacts:Binding >prep_with Familyt:e1: trigger-arg-path: interaction:Binding >prep_with themet.interceding-token ngrams: dramatically reducedtde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ras17n'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] themet1e2: trigger-arg-path: interacts >prep_with FamilytZe1: trigger-arg-path: interaction:Binding >prep_with [lemma='ras17n'] Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with Familyt&interceding-token ngrams: 69N mutationtje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='itsn1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: interacts:Binding >prep_with theme:Familyt5e1: ents2Label-mention-ngram: SHARED interaction withtRe1: trigger-arg-path: interaction:Binding >nn [lemma='itsn1'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttAe1: trigger-arg-path: interaction >prep_with Gene_or_gene_producttYe2: trigger-arg-path: interacts:Binding >nsubj [lemma='itsn1'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with theme:Familyt*interceding-token ngrams: the 69N mutationtIe1: trigger-arg-path: interaction:Binding >prep_with Gene_or_gene_productt*interceding-token ngrams: was dramaticallyt!interceding-token ngrams: findingtztrigger-to-trigger-path: e1:interaction:Binding ccomp [lemma='interact'] e2:interacts:Bindingtje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ras17n'] theme:Gene_or_gene_producttinterceding-token ngrams: 69Nt7e1: trigger-arg-path: Binding >nn [lemma='itsn1'] themetJe1: trigger-arg-path: interaction >nn [lemma='itsn1'] Gene_or_gene_productt2interceding-token ngrams: mutation consistent witht:e2: trigger-arg-path: Binding >nsubj [lemma='itsn1'] themetOe2: trigger-arg-path: Binding >nsubj [lemma='itsn1'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interaction:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttkinterceding-tokens-full-span: was dramatically reduced by the 69N mutation consistent with the finding thattLe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with themetVtrigger-to-trigger-path: e1:interaction:Binding ccomp e2:interacts:Bindingt_e2: trigger-arg-path: Negative_regulation >prep_of [lemma='acetylation'] controlled:AcetylationtMe2: trigger-arg-path: Negative_regulation prep_by Gene_or_gene_productt+e1: ents2Label-mention-ngram: and pp32 havet,interceding-token ngrams: of transcription ,tTe2: trigger-arg-path: activation:Negative_regulation >prep_of controlled:Acetylationtinterceding-token ngrams: ) ,tAe2: ents2Label-mention-ngram: acetylation by GENE_OR_GENE_PRODUCTtEe1: trigger-arg-path: interact nsubjpass Gene_or_gene_productt5e2: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCTt'interceding-token ngrams: activation oft+e1: ents2Label-mention-ngram: interact witht,e1: args2Role-mention-ngram: also been showntIe2: trigger-arg-path: activation:Negative_regulation >prep_of Acetylationt%interceding-token ngrams: inhibit thetSe2: trigger-arg-path: Negative_regulation >prep_of [lemma='acetylation'] controlledtne2: trigger-arg-path: Negative_regulation prep_by [lemma='p300'] Gene_or_gene_productt|interceding-tokens-full-span: ( ERalpha ) , to inhibit the ERalpha mediated activation of transcription , and to inhibit thet:e2: trigger-arg-path: activation prep_by controllert`e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by controllertHe1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass themetne1: trigger-arg-path: interact nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_producttae1: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] themet%interceding-token ngrams: the ERalphat*interceding-token ngrams: ERalpha mediatedt6e1: trigger-arg-path: interact nsubjpass themet+e1: args2Role-mention-ngram: THEME and pp32tke1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] themet^e2: trigger-arg-path: activation:Negative_regulation >prep_of [lemma='acetylation'] controlledtKe2: trigger-arg-path: activation >prep_of [lemma='acetylation'] Acetylationtze1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt5e1: trigger-arg-path: Binding nsubjpass themetVe1: trigger-arg-path: Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_producttge1: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt!e1: args2Role-mention-ngram: pp32tTe2: trigger-arg-path: Negative_regulation >prep_of [lemma='acetylation'] AcetylationtNe2: trigger-arg-path: activation:Negative_regulation prep_by controllertPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass themet[e2: trigger-arg-path: activation prep_by [lemma='p300'] controllertfe2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of controlled:AcetylationtJe2: trigger-arg-path: activation >prep_of [lemma='acetylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: havetee2: trigger-arg-path: activation prep_by [lemma='p300'] Gene_or_gene_producttye2: trigger-arg-path: activation:Negative_regulation prep_by [lemma='p300'] Gene_or_gene_productt>e1: trigger-arg-path: interact >prep_with Gene_or_gene_productt%interceding-token ngrams: ERalpha ) ,t+e1: ents2Label-mention-ngram: been shown tot?e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by [lemma='p300'] controllert&e1: args2Role-mention-ngram: pp32 havet|e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of [lemma='acetylation'] controlled:Acetylationt7e1: trigger-arg-path: interact:Binding >prep_with themet_e1: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_productt-interceding-token ngrams: transcription , andt interceding-token ngrams: ) , totme1: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt-interceding-token ngrams: inhibit the ERalphat0interceding-token ngrams: mediated activation oftTe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] themetWe1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass Gene_or_gene_producttXe1: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] themetHe2: trigger-arg-path: activation:Negative_regulation >prep_of controlledt(interceding-token ngrams: to inhibit thethe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='acetylation'] controlled:Acetylationtpe1: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_producttYe1: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] Gene_or_gene_producttLe1: trigger-arg-path: interact:Binding >prep_with theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: pp32 have alsot%e1: args2Role-mention-ngram: shown totpe2: trigger-arg-path: activation prep_by [lemma='p300'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: activation of SHAREDt]e1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass theme:Gene_or_gene_producttce2: trigger-arg-path: activation:Negative_regulation prep_by controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: to interactt'interceding-token ngrams: transcriptiontDe1: trigger-arg-path: interact >prep_with theme:Gene_or_gene_productt\shortest-path: ccomp [lemma='inhibit'] >dobj [lemma='activation']toe2: trigger-arg-path: activation:Negative_regulation prep_by [lemma='p300'] controllert&e1: ents2Label-mention-ngram: shown tot"e1: args2Role-mention-ngram: shownt-e1: ents2Label-mention-ngram: also been shownt#e1: ents2Label-mention-ngram: showntZe2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of controlledt^trigger-to-trigger-path: e1:interact:Binding >conj_and >dobj e2:activation:Negative_regulationtXe2: trigger-arg-path: activation:Negative_regulation prep_by Gene_or_gene_productt*e1: args2Role-mention-ngram: and pp32 havet#interceding-token ngrams: ( ERalphat-e2: args2Role-mention-ngram: of CONTROLLED byt0e1: args2Role-mention-ngram: interact with THEMEt"interceding-token ngrams: , and tot4e2: trigger-arg-path: activation >prep_of controlledtDe2: trigger-arg-path: activation prep_by Gene_or_gene_productt*e2: args2Role-mention-ngram: activation oftce1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by [lemma='p300'] Gene_or_gene_productt5interceding-token ngrams: activation of transcriptiontie1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] theme:Gene_or_gene_productt>e2: trigger-arg-path: Negative_regulation >prep_of AcetylationtLe2: trigger-arg-path: lemmatizedTrigger=activation prep_by controllertBe1: trigger-arg-path: interact >prep_with [lemma='receptor'] themet*e1: args2Role-mention-ngram: interact witht?e2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='p300'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: shown to interacttXe2: trigger-arg-path: Negative_regulation prep_by controller:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_with [lemma='receptor'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] themethe1: trigger-arg-path: interact nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt5interceding-token ngrams: ERalpha mediated activationt'e1: ents2Label-mention-ngram: pp32 havetee1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: pp32t\e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] themet&shortest-path: ccomp >dobjt.e1: ents2Label-mention-ngram: to interact witht+e1: args2Role-mention-ngram: have also beentue2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: of SHARED acetylationt!e1: args2Role-mention-ngram: beent%e1: args2Role-mention-ngram: interactt3e2: ents2Label-mention-ngram: SHARED acetylation byt!interceding-token ngrams: inhibitt%interceding-token ngrams: ( ERalpha )t&interceding-token ngrams: , to inhibitt+e2: ents2Label-mention-ngram: activation oft!e1: args2Role-mention-ngram: havet&e1: args2Role-mention-ngram: also beent/e1: trigger-arg-path: interact >prep_with themet&e1: ents2Label-mention-ngram: interacttke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] Gene_or_gene_productt*e1: args2Role-mention-ngram: been shown tot&e1: args2Role-mention-ngram: have alsotye2: trigger-arg-path: Negative_regulation prep_by [lemma='p300'] controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: of CONTROLLEDtFe1: trigger-arg-path: interact:Binding >prep_with Gene_or_gene_productt(e1: args2Role-mention-ngram: to interactt?trigger-to-trigger-path: e1:interact:Binding >conj_and [lemma='inhibit'] >dobj [lemma='activation'] e2:activation:Negative_regulationt_e1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass Gene_or_gene_productt(interceding-token ngrams: and to inhibitt!interceding-token ngrams: ERalphatSe1: trigger-arg-path: interact:Binding nsubjpass theme:Gene_or_gene_producttje2: trigger-arg-path: activation:Negative_regulation >prep_of [lemma='acetylation'] controlled:Acetylationt>e1: trigger-arg-path: interact:Binding nsubjpass themet#interceding-token ngrams: ERalpha )tRe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of controlled:AcetylationtOe2: trigger-arg-path: activation prep_by controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: and pp32t?e1: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_producttVe2: trigger-arg-path: activation >prep_of [lemma='acetylation'] controlled:Acetylationtje2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by Gene_or_gene_productt=e2: trigger-arg-path: Negative_regulation >prep_of controlledt.interceding-token ngrams: the ERalpha mediatedtAe1: trigger-arg-path: Binding >prep_with [lemma='receptor'] themet2e1: ents2Label-mention-ngram: interact with SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: acetylation byt-interceding-token ngrams: mediated activationt*interceding-token ngrams: of transcriptiontae2: trigger-arg-path: lemmatizedTrigger=activation prep_by controller:Gene_or_gene_productt)interceding-token ngrams: transcription ,tqe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='acetylation'] Acetylationt interceding-token ngrams: and totMe1: trigger-arg-path: interact:Binding nsubjpass Gene_or_gene_producttde2: trigger-arg-path: Negative_regulation prep_by [lemma='p300'] controllertJe1: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] themetqe2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of [lemma='acetylation'] AcetylationtQe1: trigger-arg-path: interact >prep_with [lemma='receptor'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: and pp32tYe1: trigger-arg-path: interact nsubjpass [lemma='TAF-1beta'] themet(e1: ents2Label-mention-ngram: been shownt-e1: args2Role-mention-ngram: to interact witht?e2: trigger-arg-path: activation:Negative_regulation prep_by [lemma='p300'] controller:Gene_or_gene_producttWe1: trigger-arg-path: interact >prep_with [lemma='receptor'] theme:Gene_or_gene_productt@e2: trigger-arg-path: activation >prep_of controlled:AcetylationtDe1: trigger-arg-path: Binding nsubjpass Gene_or_gene_productt$interceding-token ngrams: to inhibittFe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of controlledtCe2: trigger-arg-path: Negative_regulation prep_by controllertpe2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of [lemma='acetylation'] controlledte1: trigger: interacttGe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of AcetylationtIe2: trigger-arg-path: Negative_regulation >prep_of controlled:Acetylationt[e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation >prep_of AcetylationtVe2: trigger-arg-path: lemmatizedTrigger=activation prep_by Gene_or_gene_producttKe1: trigger-arg-path: interact nsubjpass theme:Gene_or_gene_producttve1: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt5e2: trigger-arg-path: activation >prep_of Acetylationtwe2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='p300'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: also beent\e2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='acetylation'] controlledt'e1: ents2Label-mention-ngram: have alsotJe1: trigger-arg-path: Binding nsubjpass theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: been shownt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and pp32t,e1: ents2Label-mention-ngram: have also beentme2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='p300'] controllert"e1: ents2Label-mention-ngram: beent+e1: args2Role-mention-ngram: pp32 have alsot?e2: trigger-arg-path: lemmatizedTrigger=activation:Negative_regulation prep_by [lemma='p300'] controller:Gene_or_gene_producttinterceding-token ngrams: , tot5e2: args2Role-mention-ngram: activation of CONTROLLEDt/e1: ents2Label-mention-ngram: shown to interactt_e2: trigger-arg-path: activation:Negative_regulation >prep_of [lemma='acetylation'] Acetylationt+e2: ents2Label-mention-ngram: SHARED at thet7e1: trigger-arg-path: Binding >dobj [lemma='ra'] Familyt5e1: trigger-arg-path: binds >dobj [lemma='ra'] Familyt_e2: trigger-arg-path: increasing nsubj [lemma='aspp2'] controller:Complext+e2: ents2Label-mention-ngram: active SHAREDt$e1: ents2Label-mention-ngram: activethe2: trigger-arg-path: Positive_activation nsubj [lemma='aspp2'] controller:Complext9e1: trigger-arg-path: lemmatizedTrigger=bind >dobj FamilytEe2: trigger-arg-path: increasing:Positive_activation >dobj >nn FamilytEe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlledtme2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt#e1: args2Role-mention-ngram: activetCe1: trigger-arg-path: binds:Binding >dobj [lemma='ra'] theme:Familytge2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='aspp2'] controllertqe2: trigger-arg-path: increasing:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt1e2: ents2Label-mention-ngram: SHARED binds activetdobj >nn controlled:Familyt%e2: ents2Label-mention-ngram: therebyt?e1: trigger-arg-path: lemmatizedTrigger=bind >dobj theme:Familyt$e2: ents2Label-mention-ngram: activet0e2: args2Role-mention-ngram: the plasma membranetIe2: trigger-arg-path: Positive_activation nsubj controller:Complext6e1: trigger-arg-path: binds:Binding >dobj theme:Familyt(e2: ents2Label-mention-ngram: membrane ,t/e2: ents2Label-mention-ngram: plasma membrane ,t'e2: args2Role-mention-ngram: membrane ,t*e2: args2Role-mention-ngram: CONTROLLER attWe2: trigger-arg-path: increasing nsubj [lemma='aspp2'] controllertLe2: trigger-arg-path: increasing:Positive_activation nsubj controllert&e2: ents2Label-mention-ngram: membranet1e2: args2Role-mention-ngram: , thereby increasingtde2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj controller:Complext$e2: ents2Label-mention-ngram: plasmat0e1: trigger-arg-path: binds:Binding >dobj Familytve2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt2e2: ents2Label-mention-ngram: , thereby increasingt7e2: ents2Label-mention-ngram: thereby increasing SHAREDt:e2: args2Role-mention-ngram: thereby increasing CONTROLLEDt8e2: trigger-arg-path: increasing nsubj controllert^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp2'] theme:Gene_or_gene_producttdobj [lemma='ra'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp2'] theme:Gene_or_gene_productt6e1: trigger-arg-path: Binding >dobj [lemma='ra'] themet5e2: trigger-arg-path: increasing nsubj Complextfe2: trigger-arg-path: increasing:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familytke2: trigger-arg-path: increasing:Positive_activation nsubj [lemma='aspp2'] controllert*e1: ents2Label-mention-ngram: binds activetHe2: trigger-arg-path: lemmatizedTrigger=increase nsubj controllert@e1: trigger-arg-path: binds:Binding >nsubj [lemma='aspp2'] themetde2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='aspp2'] ComplextLe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlled:Familyt=e1: trigger-arg-path: Binding >dobj [lemma='ra'] theme:FamilytMe1: trigger-arg-path: binds >nsubj [lemma='aspp2'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: active SHAREDt0e1: trigger-arg-path: Binding >dobj theme:Familyt\e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj controllert5e2: trigger-arg-path: increasing >dobj >nn controlledt*e2: ents2Label-mention-ngram: binds activet>e2: trigger-arg-path: Positive_activation nsubj Complext4e1: trigger-arg-path: binds >dobj [lemma='ra'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] theme:FamilytAe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj FamilytTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] theme:Familyt{e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='aspp2'] controllertxe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='aspp2'] Complext#e2: args2Role-mention-ngram: plasmatNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] Familytbe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt*e2: args2Role-mention-ngram: at the plasmat)e1: args2Role-mention-ngram: active THEMEtFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] FamilytQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp2'] themet$e2: args2Role-mention-ngram: therebyt;e1: trigger-arg-path: binds >dobj [lemma='ra'] theme:Familyt=e1: trigger-arg-path: binds:Binding >dobj [lemma='ra'] Familyt_e2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt'e2: args2Role-mention-ngram: increasingt@e2: trigger-arg-path: increasing nsubj controller:Complext/e2: args2Role-mention-ngram: membrane , therebyt/e2: args2Role-mention-ngram: thereby increasingtfe2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt-e2: ents2Label-mention-ngram: plasma membranetPe2: trigger-arg-path: increasing:Positive_activation >dobj >nn controlled:Familyt`e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlled:Familytdtrigger-to-trigger-path: e1:binds:Binding >vmod [lemma='increase'] e2:increasing:Positive_activationt8e1: trigger-arg-path: binds >nsubj [lemma='aspp2'] themetUe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn FamilytIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp2'] themet'e2: ents2Label-mention-ngram: , therebytAe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn Familyt2e2: args2Role-mention-ngram: increasing CONTROLLEDthe2: trigger-arg-path: increasing:Positive_activation nsubj [lemma='aspp2'] Complext`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp2'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: binds active SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj ComplextMe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] themet,e2: args2Role-mention-ngram: plasma membranet(e2: ents2Label-mention-ngram: increasingtEe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] themet/e1: args2Role-mention-ngram: binds active THEMEt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt0e2: ents2Label-mention-ngram: membrane , therebyt0e2: ents2Label-mention-ngram: thereby increasingt*e1: trigger-arg-path: Binding >dobj Familyt$e2: ents2Label-mention-ngram: at thet`e2: trigger-arg-path: Positive_activation nsubj [lemma='aspp2'] controllert/e1: args2Role-mention-ngram: THEME binds activetOe1: trigger-arg-path: binds:Binding >nsubj [lemma='aspp2'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlledtse2: trigger-arg-path: increasing:Positive_activation nsubj [lemma='aspp2'] controller:ComplextRe2: trigger-arg-path: increasing >dobj [lemma='signaling'] >nn [lemma='ra'] FamilytVe2: trigger-arg-path: increasing >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt]e2: trigger-arg-path: Positive_activation nsubj [lemma='aspp2'] Complexte2: trigger: increasingt+e2: ents2Label-mention-ngram: at the plasmatXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp2'] Gene_or_gene_productt(e1: trigger-arg-path: binds >dobj FamilytQtrigger-to-trigger-path: e1:binds:Binding >vmod e2:increasing:Positive_activationtOe1: trigger-arg-path: Binding >nsubj [lemma='aspp2'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: active SHARED attIe2: trigger-arg-path: increasing:Positive_activation nsubj ComplextUe1: trigger-arg-path: binds:Binding >nsubj [lemma='aspp2'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: , therebyt1e2: ents2Label-mention-ngram: the plasma membranetoe2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='aspp2'] controller:Complextje2: trigger-arg-path: increasing:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt[e2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt.e1: trigger-arg-path: binds >dobj theme:FamilytTe2: trigger-arg-path: increasing:Positive_activation nsubj controller:Complextfe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='signaling'] >nn [lemma='ra'] controlledtEe2: trigger-arg-path: lemmatizedTrigger=increase nsubj ComplextPe2: trigger-arg-path: lemmatizedTrigger=increase nsubj controller:Complext)e1: args2Role-mention-ngram: binds activet#e2: args2Role-mention-ngram: at thet1e2: ents2Label-mention-ngram: binds active SHAREDtAe2: trigger-arg-path: Positive_activation nsubj controllert1e1: ents2Label-mention-ngram: SHARED binds activetTe2: trigger-arg-path: increasing nsubj [lemma='aspp2'] Complext]e2: trigger-arg-path: increasing >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:FamilytGe1: trigger-arg-path: binds >nsubj [lemma='aspp2'] Gene_or_gene_productt:e2: trigger-arg-path: Positive_activation >dobj >nn Familyt(e2: ents2Label-mention-ngram: the plasmatEe2: trigger-arg-path: Positive_activation >dobj >nn controlled:Familyt.e2: args2Role-mention-ngram: plasma membrane ,tIe1: trigger-arg-path: Binding >nsubj [lemma='aspp2'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='aspp2'] controller:Complext%e2: args2Role-mention-ngram: membranet.e2: args2Role-mention-ngram: CONTROLLER at thet'e2: args2Role-mention-ngram: the plasmatGe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj theme:Familyt1e2: trigger-arg-path: increasing >dobj >nn FamilytIe2: trigger-arg-path: increasing:Positive_activation >dobj >nn controlledt:e1: trigger-arg-path: Binding >nsubj [lemma='aspp2'] themet/e2: ents2Label-mention-ngram: increasing SHAREDt;e2: trigger-arg-path: bound >dobj [lemma='ra'] theme:Familyt7e2: trigger-arg-path: Binding >dobj [lemma='ra'] FamilytMe2: trigger-arg-path: Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: wt THEMEt-e2: ents2Label-mention-ngram: bound wt SHAREDt4e2: trigger-arg-path: bound >dobj [lemma='ra'] themet+e2: args2Role-mention-ngram: THEME bound wtt6e2: trigger-arg-path: bound:Binding >dobj theme:Familyte1: args2Role-mention-ngram: wtt e2: ents2Label-mention-ngram: wttEe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] themet0e1: trigger-arg-path: bound:Binding >dobj Familyt'e2: trigger-arg-path: bound >dobj themet%e2: args2Role-mention-ngram: bound wttGe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj theme:FamilytCe1: trigger-arg-path: bound:Binding >dobj [lemma='ra'] theme:FamilytTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] theme:Familyt'e1: ents2Label-mention-ngram: wt SHAREDt;e1: trigger-arg-path: bound >dobj [lemma='ra'] theme:Familyt(e2: trigger-arg-path: bound >dobj Familyt e1: ents2Label-mention-ngram: wttLe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] theme:Familyt?e2: trigger-arg-path: bound:Binding >nsubj Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED boundt-e1: ents2Label-mention-ngram: SHARED bound wtt%e1: args2Role-mention-ngram: bound wtte2: args2Role-mention-ngram: wtt+e2: args2Role-mention-ngram: bound wt THEMEtdobj [lemma='ra'] themet5e1: trigger-arg-path: bound >dobj [lemma='ra'] Familyt&e2: ents2Label-mention-ngram: bound wtt/e2: trigger-arg-path: bound:Binding >dobj themet&e1: ents2Label-mention-ngram: bound wtt?e2: trigger-arg-path: lemmatizedTrigger=bind >dobj theme:Familyt6e2: trigger-arg-path: Binding >dobj [lemma='ra'] themet*e2: ents2Label-mention-ngram: SHARED boundt.e2: trigger-arg-path: bound >dobj theme:FamilytMe2: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] Gene_or_gene_productt0e2: trigger-arg-path: bound:Binding >dobj Familyt-e1: ents2Label-mention-ngram: bound wt SHAREDtEe2: trigger-arg-path: bound:Binding >nsubj theme:Gene_or_gene_productt(e1: trigger-arg-path: bound >dobj FamilytGe2: trigger-arg-path: Binding >nsubj [lemma='gtp'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME bound wtt9e2: trigger-arg-path: lemmatizedTrigger=bind >dobj Familyt=e2: trigger-arg-path: Binding >dobj [lemma='ra'] theme:FamilytCe2: trigger-arg-path: bound:Binding >dobj [lemma='ra'] theme:FamilytAe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj Familyt+e1: args2Role-mention-ngram: bound wt THEMEt0e2: trigger-arg-path: Binding >dobj theme:Familyt.e1: trigger-arg-path: bound >dobj theme:Familyt>e2: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] themetNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] Familyt7e2: trigger-arg-path: bound >nsubj Gene_or_gene_productt(e2: trigger-arg-path: bound >nsubj themet^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] Gene_or_gene_productt'e1: trigger-arg-path: bound >dobj themetKe2: trigger-arg-path: bound >nsubj [lemma='gtp'] theme:Gene_or_gene_productt*e2: trigger-arg-path: Binding >dobj Familyt4e1: trigger-arg-path: bound >dobj [lemma='ra'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_productt5e2: trigger-arg-path: bound >dobj [lemma='ra'] FamilytMe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ra'] themetSe2: trigger-arg-path: bound:Binding >nsubj [lemma='gtp'] theme:Gene_or_gene_producttdobj [lemma='ra'] themet=e1: trigger-arg-path: bound:Binding >dobj [lemma='ra'] Familyt=e2: trigger-arg-path: bound:Binding >dobj [lemma='ra'] FamilytOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gtp'] themetEe2: trigger-arg-path: bound >nsubj [lemma='gtp'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] theme:Gene_or_gene_productt=e2: trigger-arg-path: bound >nsubj theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] Gene_or_gene_productt0e2: trigger-arg-path: bound:Binding >nsubj themet6e2: trigger-arg-path: bound >nsubj [lemma='gtp'] themet/e1: trigger-arg-path: bound:Binding >dobj themet8e2: trigger-arg-path: Binding >nsubj [lemma='gtp'] themet'e2: ents2Label-mention-ngram: wt SHAREDtGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gtp'] themet6e1: trigger-arg-path: bound:Binding >dobj theme:Familyt-e2: ents2Label-mention-ngram: SHARED bound wttFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ra'] Familyt%e2: args2Role-mention-ngram: wt THEMEtPe2: trigger-arg-path: degraded:Negative_regulation auxpass controlledtqe2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='proteasome'] controller:Familyt$e2: ents2Label-mention-ngram: and ist(e2: args2Role-mention-ngram: degraded byt6e1: ents2Label-mention-ngram: phosphorylated by SHAREDt+e2: ents2Label-mention-ngram: by SHARED andt*e2: ents2Label-mention-ngram: subsequentlytLe2: trigger-arg-path: Negative_regulation >agent [lemma='proteasome'] FamilytQe2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent Familyt(e2: ents2Label-mention-ngram: the FAMILYtue2: trigger-arg-path: degraded auxpass [lemma='be'] controlled:Positive_regulationtEe2: trigger-arg-path: degraded >agent [lemma='proteasome'] controllertae2: trigger-arg-path: lemmatizedTrigger=degrade auxpass controlled:Positive_regulationt~e2: trigger-arg-path: degraded:Negative_regulation auxpass [lemma='be'] Positive_regulationt,e2: ents2Label-mention-ngram: phosphorylatedt7e2: trigger-arg-path: Negative_regulation >agent FamilytAe2: trigger-arg-path: lemmatizedTrigger=degrade >agent controllertXe1: trigger-arg-path: Positive_regulation >agent [lemma='gsk3beta'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: phosphorylated bytLe2: trigger-arg-path: degraded >agent [lemma='proteasome'] controller:FamilytGshortest-path: auxpass [lemma='be']t?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass [lemma='be'] controlled:Positive_regulationtSe1: trigger-arg-path: phosphorylated >agent [lemma='gsk3beta'] Gene_or_gene_productt7e2: trigger-arg-path: degraded >agent controller:FamilytKe2: trigger-arg-path: degraded:Negative_regulation >agent controller:FamilytRe2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='proteasome'] Familyt,e2: trigger-arg-path: degraded >agent Familyt#e2: args2Role-mention-ngram: and istae2: trigger-arg-path: degraded auxpass [lemma='be'] controlledt6e2: ents2Label-mention-ngram: phosphorylated by SHAREDtce1: trigger-arg-path: Positive_regulation >agent [lemma='gsk3beta'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: is phosphorylated byt+e2: ents2Label-mention-ngram: SHARED and ist,e2: args2Role-mention-ngram: degraded by thetIe1: trigger-arg-path: phosphorylated >agent [lemma='gsk3beta'] controllertMe2: trigger-arg-path: lemmatizedTrigger=degrade auxpass controlledt)e2: args2Role-mention-ngram: subsequentlytue2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass controlled:Positive_regulationt+e2: args2Role-mention-ngram: CONTROLLED andt@e2: trigger-arg-path: degraded:Negative_regulation >agent Familyt?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass [lemma='be'] controlledt/e2: ents2Label-mention-ngram: is phosphorylatedt6e2: ents2Label-mention-ngram: is subsequently degradedtBe2: trigger-arg-path: Negative_regulation >agent controller:Familyt0e2: trigger-arg-path: degraded >agent controllertle2: trigger-arg-path: Negative_regulation auxpass [lemma='be'] controlledtZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='gsk3beta'] controllert3e2: ents2Label-mention-ngram: subsequently degradedtfe2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='proteasome'] Familyt%e2: args2Role-mention-ngram: degradedtje2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass Positive_regulationtje2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='proteasome'] controllertoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='gsk3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: degraded:Negative_regulation auxpass [lemma='be'] controlled:Positive_regulationt1e2: ents2Label-mention-ngram: and is subsequentlytPe2: trigger-arg-path: degraded auxpass controlled:Positive_regulationt.e2: args2Role-mention-ngram: CONTROLLED and ist+e2: ents2Label-mention-ngram: by the FAMILYtae2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass controlledtztrigger-to-trigger-path: e1:phosphorylated:Positive_regulation >conj_and [lemma='degrade'] e2:degraded:Negative_regulationtue2: trigger-arg-path: degraded:Negative_regulation auxpass [lemma='be'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent controllert6e1: ents2Label-mention-ngram: SHARED is phosphorylatedtDe2: trigger-arg-path: degraded:Negative_regulation >agent controllert6e2: ents2Label-mention-ngram: subsequently degraded bytHe2: trigger-arg-path: lemmatizedTrigger=degrade >agent controller:Familyt&e2: ents2Label-mention-ngram: degradedt5e2: args2Role-mention-ngram: is subsequently degradedtge1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='gsk3beta'] Gene_or_gene_producttUe2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='proteasome'] Familyt=e2: trigger-arg-path: lemmatizedTrigger=degrade >agent Familyt]e2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='proteasome'] controller:Familytne1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='gsk3beta'] controllertauxpass controlledtVe2: trigger-arg-path: lemmatizedTrigger=degrade auxpass Positive_regulationtAe2: trigger-arg-path: degraded >agent [lemma='proteasome'] Familyt-e2: ents2Label-mention-ngram: is subsequentlytYe2: trigger-arg-path: degraded:Negative_regulation auxpass Positive_regulationtNe1: trigger-arg-path: Positive_regulation >agent [lemma='gsk3beta'] controllertxe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='gsk3beta'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='proteasome'] controllertYe2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='proteasome'] controllert)e2: ents2Label-mention-ngram: degraded byt[e2: trigger-arg-path: Negative_regulation auxpass controlled:Positive_regulationt?e2: trigger-arg-path: Negative_regulation auxpass [lemma='be'] controlled:Positive_regulationtEe2: trigger-arg-path: degraded auxpass Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='gsk3beta'] controller:Gene_or_gene_productte2: trigger: degradedt?e2: trigger-arg-path: lemmatizedTrigger=degrade auxpass [lemma='be'] controlled:Positive_regulationt0e2: args2Role-mention-ngram: and is subsequentlytde1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='gsk3beta'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: is phosphorylatedt{e2: trigger-arg-path: lemmatizedTrigger=degrade auxpass [lemma='be'] Positive_regulationtde2: trigger-arg-path: degraded:Negative_regulation auxpass controlled:Positive_regulationt]e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='gsk3beta'] controllert,e2: args2Role-mention-ngram: is subsequentlyt2e2: args2Role-mention-ngram: subsequently degradedt6e2: ents2Label-mention-ngram: SHARED is phosphorylatedtPe2: trigger-arg-path: Negative_regulation auxpass Positive_regulationt`e2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='proteasome'] controller:Familytje2: trigger-arg-path: degraded auxpass [lemma='be'] Positive_regulationt5e2: args2Role-mention-ngram: subsequently degraded bytue2: trigger-arg-path: Negative_regulation auxpass [lemma='be'] Positive_regulationtGe2: trigger-arg-path: Negative_regulation auxpass controlledtre2: trigger-arg-path: lemmatizedTrigger=degrade auxpass [lemma='be'] controlledt\e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent controller:Familyt^e1: trigger-arg-path: phosphorylated >agent [lemma='gsk3beta'] controller:Gene_or_gene_productt;e2: trigger-arg-path: Negative_regulation >agent controllert?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation auxpass [lemma='be'] Positive_regulationt-e2: ents2Label-mention-ngram: degraded by thet'e2: ents2Label-mention-ngram: SHARED ist2e2: ents2Label-mention-ngram: is phosphorylated bytre1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='gsk3beta'] controller:Gene_or_gene_producttPe2: trigger-arg-path: Negative_regulation >agent [lemma='proteasome'] controllerthtrigger-to-trigger-path: e1:phosphorylated:Positive_regulation >conj_and e2:degraded:Negative_regulationtWe2: trigger-arg-path: Negative_regulation >agent [lemma='proteasome'] controller:Familytshortest-path: nntTe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn Gene_or_gene_producttGe2: trigger-arg-path: interaction:Binding >nn [lemma='ra'] theme:Familyt(e1: args2Role-mention-ngram: THEME THEMEt,e2: trigger-arg-path: interaction >nn Familyt8e2: trigger-arg-path: interaction >nn [lemma='ra'] themet:e2: trigger-arg-path: interaction >nn Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='gdp'] Gene_or_gene_productt9e2: trigger-arg-path: interaction >nn [lemma='ra'] Familyt>e1: trigger-arg-path: lemmatizedTrigger=binding nn Familyt>e2: trigger-arg-path: lemmatizedTrigger=interaction >nn Familyt0e2: args2Role-mention-ngram: binding interactiontxe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gdp'] Gene_or_gene_productt@e1: trigger-arg-path: binding nn theme:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn Familyt@e1: trigger-arg-path: Binding nn theme:Gene_or_gene_producttAe2: trigger-arg-path: interaction:Binding >nn [lemma='gdp'] themet2e2: trigger-arg-path: interaction >nn theme:FamilytRe2: trigger-arg-path: lemmatizedTrigger=interaction >nn theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='gdp'] themet3e2: ents2Label-mention-ngram: SHARED SHARED bindingtSe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='gdp'] themetDe2: trigger-arg-path: lemmatizedTrigger=interaction >nn theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn theme:FamilytBe1: trigger-arg-path: binding:Binding nn Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gdp'] theme:Gene_or_gene_productt2e1: trigger-arg-path: Binding nn theme:Familyt~e1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gdp'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED bindingt^e1: trigger-arg-path: Binding nn [lemma='gdp'] Gene_or_gene_producttOe1: trigger-arg-path: Binding nn [lemma='ra'] FamilytQe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] theme:Familytbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='gdp'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='gdp'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interaction:Binding >nn [lemma='gdp'] theme:Gene_or_gene_productt:e1: trigger-arg-path: binding nn Gene_or_gene_producttHe2: trigger-arg-path: interaction:Binding >nn theme:Gene_or_gene_productt:shortest-path: nn [lemma='gdp']tNe1: trigger-arg-path: binding nn [lemma='ra'] themet9e2: trigger-arg-path: interaction >nn [lemma='gdp'] themet2e1: trigger-arg-path: binding nn theme:Familyt:e1: trigger-arg-path: Binding nn Gene_or_gene_producttNe2: trigger-arg-path: interaction >nn [lemma='gdp'] theme:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn themetJe2: trigger-arg-path: Binding >nn [lemma='gdp'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='ra'] theme:Familyt@e2: trigger-arg-path: interaction >nn theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME bindingtFe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn FamilytYe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] theme:Familytie1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] Familyt.e2: trigger-arg-path: Binding >nn theme:Familyt+e1: trigger-arg-path: binding nn themet+e2: ents2Label-mention-ngram: SHARED SHAREDt0e1: args2Role-mention-ngram: THEME THEME bindingtZe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn theme:Gene_or_gene_producttBe2: trigger-arg-path: interaction:Binding >nn Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gdp'] themet8e2: ents2Label-mention-ngram: SHARED binding interactiontOe1: trigger-arg-path: Binding nn [lemma='gdp'] themetLe1: trigger-arg-path: lemmatizedTrigger=binding nn Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn theme:Gene_or_gene_productt^e1: trigger-arg-path: binding nn [lemma='gdp'] Gene_or_gene_producttHe1: trigger-arg-path: binding:Binding nn theme:Gene_or_gene_producttle1: trigger-arg-path: binding:Binding nn [lemma='gdp'] theme:Gene_or_gene_producttde1: trigger-arg-path: binding nn [lemma='gdp'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding nn [lemma='ra'] Familytde1: trigger-arg-path: Binding nn [lemma='gdp'] theme:Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=binding nn theme:Familyt3e2: trigger-arg-path: interaction:Binding >nn themet:e2: trigger-arg-path: interaction:Binding >nn theme:Familythe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] themet?e2: trigger-arg-path: interaction >nn [lemma='ra'] theme:Familytpe1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gdp'] Gene_or_gene_productt=e2: trigger-arg-path: lemmatizedTrigger=interaction >nn themetHe2: trigger-arg-path: interaction >nn [lemma='gdp'] Gene_or_gene_producttNe1: trigger-arg-path: Binding nn [lemma='ra'] themet0e2: args2Role-mention-ngram: THEME THEME bindingtae1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gdp'] themetRe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] themetOe1: trigger-arg-path: binding nn [lemma='gdp'] themet3e1: trigger-arg-path: binding:Binding nn themet4e2: trigger-arg-path: interaction:Binding >nn Familyt:e1: trigger-arg-path: binding:Binding nn theme:Familyt+e1: ents2Label-mention-ngram: SHARED SHAREDt\trigger-to-trigger-path: e1:binding:Binding nn [lemma='ra'] Familyt4e2: trigger-arg-path: Binding >nn [lemma='ra'] themetZe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='gdp'] Gene_or_gene_producttWe1: trigger-arg-path: binding:Binding nn [lemma='gdp'] themetKe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] FamilytWe1: trigger-arg-path: binding:Binding nn [lemma='ra'] FamilytPe2: trigger-arg-path: interaction:Binding >nn [lemma='gdp'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=interaction >nn Gene_or_gene_producttVe1: trigger-arg-path: binding:Binding nn [lemma='ra'] themet,e1: trigger-arg-path: Binding nn Familyt]e1: trigger-arg-path: binding:Binding nn [lemma='ra'] theme:Familythe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='gdp'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: THEME THEMEt1e2: ents2Label-mention-ngram: binding interactiontfe1: trigger-arg-path: binding:Binding nn [lemma='gdp'] Gene_or_gene_productt4e1: trigger-arg-path: binding:Binding nn Familyt6e2: args2Role-mention-ngram: THEME binding interactiont=e1: trigger-arg-path: lemmatizedTrigger=binding nn themetEe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn themetUe1: trigger-arg-path: Binding nn [lemma='ra'] theme:Familyt;e2: trigger-arg-path: Binding >nn [lemma='ra'] theme:FamilytLe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn theme:Familyt(e2: trigger-arg-path: Binding >nn Familyt+e2: trigger-arg-path: interaction >nn themetUe1: trigger-arg-path: binding nn [lemma='ra'] theme:Familyt`e1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='ra'] themetFtrigger-to-trigger-path: e1:binding:Binding nn [lemma='ra'] themet+e1: trigger-arg-path: Binding nn themetTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='gdp'] themetJe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] themetAe2: trigger-arg-path: interaction:Binding >nn [lemma='ra'] Familyt3e1: ents2Label-mention-ngram: SHARED SHARED bindingtSe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] Familyt,e1: trigger-arg-path: binding nn FamilytRe1: trigger-arg-path: lemmatizedTrigger=binding nn theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='ra'] FamilytIe1: trigger-arg-path: Binding >prep_to [lemma='SMO'] Gene_or_gene_productt.e2: args2Role-mention-ngram: complex THEME andt?interceding-tokens-full-span: , whereas in presence of Hh , thetce2: trigger-arg-path: complex conj_and [lemma='ptch1'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ptch1'] theme:Gene_or_gene_producttHe2: trigger-arg-path: complex:Binding conj_and Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >nsubj [lemma='ptch1'] themet>e2: trigger-arg-path: complex nsubj [lemma='ptch1'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='SMO'] themet1e2: trigger-arg-path: complex conj_and themet^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='SMO'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ptch1'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and Gene_or_gene_productt(interceding-token ngrams: in presence oft8e1: trigger-arg-path: binds >nsubj [lemma='ptch1'] themetOe1: trigger-arg-path: binds:Binding >nsubj [lemma='ptch1'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ptch1'] themetMe1: trigger-arg-path: binds >prep_to [lemma='SMO'] theme:Gene_or_gene_productt9e2: trigger-arg-path: complex:Binding nsubj [lemma='ptch1'] themetee2: trigger-arg-path: complex:Binding conj_and [lemma='ptch1'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=complex conj_and [lemma='ptch1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=complex e2: trigger-arg-path: Binding nsubj [lemma='ptch1'] theme:Gene_or_gene_productt'e2: trigger-arg-path: Binding nsubj [lemma='ptch1'] Gene_or_gene_productt#interceding-token ngrams: , whereast/e2: trigger-arg-path: complex:Binding conj_and theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex:Binding advcl >nsubj >nntkshortest-path: advcl [lemma='internalize'] >nsubj [lemma='hh'] >nn [lemma='complex']t9e2: trigger-arg-path: complex:Binding conj_and themet(interceding-token ngrams: presence of Hht`e2: trigger-arg-path: lemmatizedTrigger=complex conj_and [lemma='ptch1'] themetFe2: trigger-arg-path: complex:Binding prep_to [lemma='SMO'] theme:Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding nsubj [lemma='ptch1'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_to [lemma='SMO'] theme:Gene_or_gene_producttDe2: trigger-arg-path: complex nsubj [lemma='ptch1'] theme:Gene_or_gene_productt%interceding-token ngrams: in presencetOe1: trigger-arg-path: Binding >nsubj [lemma='ptch1'] theme:Gene_or_gene_producttinterceding-token ngrams: Hh ,the2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and [lemma='ptch1'] themet9e2: trigger-arg-path: lemmatizedTrigger=complex conj_and themet`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='SMO'] themet@e2: trigger-arg-path: Binding conj_and Gene_or_gene_productt"interceding-token ngrams: presencetNe2: trigger-arg-path: Binding conj_and [lemma='ptch1'] themetFe2: trigger-arg-path: complex conj_and theme:Gene_or_gene_productt%interceding-token ngrams: presence oftQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='SMO'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='SMO'] themet9e2: ents2Label-mention-ngram: complex SIMPLE_CHEMICAL andtce2: trigger-arg-path: Binding conj_and [lemma='ptch1'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:binds:Binding >advcl [lemma='internalize'] >nsubj [lemma='hh'] >nn [lemma='complex'] e2:complex:Bindingt1e2: trigger-arg-path: Binding conj_and [lemma='ptch1'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='ptch1'] themetNe2: trigger-arg-path: complex conj_and [lemma='ptch1'] themetRe2: trigger-arg-path: lemmatizedTrigger=complex conj_and Gene_or_gene_producttDe2: trigger-arg-path: Binding conj_and [lemma='ptch1'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='SMO'] Gene_or_gene_productt1e2: trigger-arg-path: Binding conj_and themetLe2: trigger-arg-path: complex:Binding prep_to [lemma='SMO'] themet'e2: trigger-arg-path: complex prep_to [lemma='SMO'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and [lemma='ptch1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex conj_and theme:Gene_or_gene_productt!interceding-token ngrams: of Hh ,t$interceding-token ngrams: whereas intNe2: trigger-arg-path: complex:Binding conj_and theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and [lemma='ptch1'] theme:Gene_or_gene_productt]e2: trigger-arg-path: complex conj_and [lemma='ptch1'] Gene_or_gene_producttinterceding-token ngrams: of Hht@e2: trigger-arg-path: complex conj_and Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='SMO'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and [lemma='ptch1'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_and themet1e2: trigger-arg-path: complex nsubj [lemma='ptch1'] theme:Gene_or_gene_productt4e2: trigger-arg-path: complex conj_and [lemma='ptch1'] Gene_or_gene_producttNtrigger-to-trigger-path: e1:binds:Binding >advcl >nsubj >nn e2:complex:Bindingtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='SMO'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binds >prep_to [lemma='SMO'] Gene_or_gene_productt-interceding-token ngrams: whereas in presencet?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >dobj [lemma='shp2'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shp2'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by themet?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themetae1: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_productte1: THEME: 5t^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shp2'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep >ccomp >xcomp >prep_by themetae2: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_productt>e1: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] themetDe1: trigger-arg-path: bound:Binding >dobj theme:Gene_or_gene_productt>e1: trigger-arg-path: bound:Binding >dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: bound SHAREDt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shp2'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_producttEe2: trigger-arg-path: bound >dobj [lemma='shp2'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_productt?e2: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themet8e1: trigger-arg-path: Binding >dobj [lemma='shp2'] themetLe1: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by themetUe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by themetde2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themetje2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_producttSe2: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themet[e2: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themet>e2: trigger-arg-path: bound:Binding >dobj Gene_or_gene_productt6e1: trigger-arg-path: bound >dobj [lemma='shp2'] themetle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e1: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_producttDe2: trigger-arg-path: bound:Binding >dobj theme:Gene_or_gene_productt6e1: trigger-arg-path: bound >dobj Gene_or_gene_productte2: THEME: 5t[e1: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e2: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] themetKe1: trigger-arg-path: bound >dobj [lemma='shp2'] theme:Gene_or_gene_producttdobj theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_productt?e2: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt1shortest-path: dobj [lemma='shp2'] themet?e1: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by themetre2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_productt>e2: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] themet?e2: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] Gene_or_gene_producttKe2: trigger-arg-path: bound >dobj [lemma='shp2'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_producttSe1: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_producttGe1: trigger-arg-path: Binding >dobj [lemma='shp2'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >dobj [lemma='shp2'] themet6e2: trigger-arg-path: bound >dobj Gene_or_gene_producttSe2: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by themet6e2: trigger-arg-path: bound >dobj [lemma='shp2'] themetEe1: trigger-arg-path: bound >dobj [lemma='shp2'] Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_producttdobj theme:Gene_or_gene_producttYe1: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: SHARED bound SHAREDtMe1: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] Gene_or_gene_productt[e2: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] themetUe2: trigger-arg-path: Binding >nsubj >dep >ccomp >xcomp >prep_by Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shp2'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shp2'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themet?e2: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themetMe2: trigger-arg-path: bound:Binding >dobj [lemma='shp2'] Gene_or_gene_productt?e1: trigger-arg-path: bound >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themetDe2: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by themet?e2: trigger-arg-path: Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='shp2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] themetGe2: trigger-arg-path: Binding >dobj [lemma='shp2'] Gene_or_gene_producttYe2: trigger-arg-path: bound >nsubj >dep >ccomp >xcomp >prep_by theme:Gene_or_gene_producttLe2: trigger-arg-path: bound:Binding >nsubj >dep >ccomp >xcomp >prep_by themet1e2: ents2Label-mention-ngram: SHARED bound SHAREDt?shortest-path: nsubj >dep >ccomp >xcomp >prep_by themet?e2: trigger-arg-path: bound:Binding >nsubj [lemma='co-stimulation'] >dep [lemma='bind'] >ccomp [lemma='decrease'] >xcomp [lemma='owe'] >prep_by [lemma='gab1'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >dobj [lemma='shp2'] theme:Gene_or_gene_productt6e2: args2Role-mention-ngram: CONTROLLER signalling viatJe1: trigger-arg-path: Negative_regulation >nsubj [lemma='this'] controllert7e1: args2Role-mention-ngram: CONTROLLER inhibits mTORC1t6e1: ents2Label-mention-ngram: TSC2 and phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: signallingt%e1: args2Role-mention-ngram: TSC2 andtPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='this'] controllertYe1: trigger-arg-path: Negative_regulation >nsubj [lemma='this'] controller:Generic_entityt1e1: ents2Label-mention-ngram: and phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='this'] controller:Generic_entitytccomp [lemma='induce'] e2:induced:Positive_regulationt,e1: args2Role-mention-ngram: inhibits mTORC1t2e1: args2Role-mention-ngram: induced activation oft(e1: ents2Label-mention-ngram: signallingt)e1: args2Role-mention-ngram: AMPK inducedt&e2: ents2Label-mention-ngram: TSC2 andtoe2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: of TSC2 andt&e1: ents2Label-mention-ngram: TSC2 andtce2: trigger-arg-path: induced >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] Gene_or_gene_productt4e2: args2Role-mention-ngram: AMPK induced activationtme2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controllertne2: trigger-arg-path: induced >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controller:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: activation of TSC2tde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='this'] controllerthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='this'] Generic_entityt,e1: ents2Label-mention-ngram: GENERIC_ENTITYt?e1: trigger-arg-path: inhibits >nsubj controller:Generic_entitytYe2: trigger-arg-path: induced >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controllert0e1: ents2Label-mention-ngram: induced activationt3e1: ents2Label-mention-ngram: induced activation oft2e2: args2Role-mention-ngram: CONTROLLER signallingt e1: args2Role-mention-ngram: viatWe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='this'] Generic_entitytpshortest-path: ccomp [lemma='induce'] >nsubj [lemma='signalling'] >nn [lemma='mtorc1']tYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj Generic_entitytJe1: trigger-arg-path: Negative_regulation >nsubj controller:Generic_entityt0e2: args2Role-mention-ngram: TSC2 and CONTROLLEDt?e1: trigger-arg-path: Negative_regulation >nsubj Generic_entitytEe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Generic_entitytPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:Generic_entityt"e1: ents2Label-mention-ngram: AMPKt6e2: ents2Label-mention-ngram: TSC2 and phosphorylationtbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn Gene_or_gene_productt,e1: ents2Label-mention-ngram: signalling viatTe2: trigger-arg-path: Positive_regulation >nsubj >nn controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: activation of TSC2t1e1: ents2Label-mention-ngram: signalling via AMPKt1e2: ents2Label-mention-ngram: and phosphorylationtje2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controllert3e2: ents2Label-mention-ngram: induced activation oft)e1: ents2Label-mention-ngram: of TSC2 andt!e1: args2Role-mention-ngram: TSC2t(e2: args2Role-mention-ngram: of TSC2 andt e2: args2Role-mention-ngram: viatde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controller:Generic_entityt\e2: trigger-arg-path: induced:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: and CONTROLLEDt/e1: ents2Label-mention-ngram: mTORC1 signallingtTe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='this'] Generic_entityt0e2: ents2Label-mention-ngram: activation of TSC2t,e2: ents2Label-mention-ngram: signalling viat0e2: ents2Label-mention-ngram: induced activationt%e2: ents2Label-mention-ngram: of TSC2t5e1: ents2Label-mention-ngram: AMPK induced activationt%e2: args2Role-mention-ngram: via AMPKtDe1: trigger-arg-path: inhibits:Negative_regulation >nsubj controllert.e2: ents2Label-mention-ngram: via AMPK inducedt!e2: args2Role-mention-ngram: TSC2t/e2: args2Role-mention-ngram: induced activationtHe1: trigger-arg-path: inhibits:Negative_regulation >nsubj Generic_entityt$e1: args2Role-mention-ngram: of TSC2te2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: AMPK inducedt%e1: args2Role-mention-ngram: via AMPKt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT signallingt0e1: trigger-arg-path: inhibits >nsubj controllert7e1: args2Role-mention-ngram: inhibits mTORC1 signallingtHe2: trigger-arg-path: induced >nsubj >nn controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: inhibits mTORC1t&e1: ents2Label-mention-ngram: via AMPKt&e2: ents2Label-mention-ngram: via AMPKt^trigger-to-trigger-path: e1:inhibits:Negative_regulation >ccomp e2:induced:Positive_regulationtse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='this'] controller:Generic_entityt0e1: args2Role-mention-ngram: signalling via AMPKt3e1: ents2Label-mention-ngram: mTORC1 signalling viat*e2: ents2Label-mention-ngram: AMPK inducedt(e1: args2Role-mention-ngram: of TSC2 andt5e2: ents2Label-mention-ngram: AMPK induced activationt4e2: ents2Label-mention-ngram: and phosphorylation oftbe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='this'] controller:Generic_entityt+e2: args2Role-mention-ngram: signalling viat-e2: args2Role-mention-ngram: via AMPK inducedtYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controller:Gene_or_gene_productt'shortest-path: ccomp >nsubj >nntNe1: trigger-arg-path: inhibits >nsubj [lemma='this'] controller:Generic_entityt!e1: ents2Label-mention-ngram: viat(e2: ents2Label-mention-ngram: signallingtXe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn controllertIe2: trigger-arg-path: Positive_regulation >nsubj >nn Gene_or_gene_productt4e1: args2Role-mention-ngram: AMPK induced activationt2e1: args2Role-mention-ngram: mTORC1 signalling viat%e1: ents2Label-mention-ngram: of TSC2t.e1: ents2Label-mention-ngram: via AMPK inducedt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: signalling via AMPKt'e2: args2Role-mention-ngram: signallingtGe2: trigger-arg-path: induced:Positive_regulation >nsubj >nn controllert"e1: ents2Label-mention-ngram: TSC2t=e2: trigger-arg-path: induced >nsubj >nn Gene_or_gene_productt0e1: args2Role-mention-ngram: TSC2 and CONTROLLEDtCe1: trigger-arg-path: inhibits >nsubj [lemma='this'] Generic_entityt3e2: trigger-arg-path: induced >nsubj >nn controllert2e2: args2Role-mention-ngram: induced activation oftSe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='this'] controllert$e2: args2Role-mention-ngram: of TSC2tNe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn Gene_or_gene_productt4e1: trigger-arg-path: inhibits >nsubj Generic_entityt!e1: args2Role-mention-ngram: AMPKt0e2: args2Role-mention-ngram: signalling via AMPKtwe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] Gene_or_gene_productt)e2: args2Role-mention-ngram: AMPK inducedt+e1: args2Role-mention-ngram: signalling viat$e1: ents2Label-mention-ngram: mTORC1t8e1: ents2Label-mention-ngram: inhibits mTORC1 signallingt%e2: args2Role-mention-ngram: TSC2 andt?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >nsubj >nn controllert"e2: ents2Label-mention-ngram: TSC2tDe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controllert#e1: args2Role-mention-ngram: mTORC1t~e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controllert!e2: ents2Label-mention-ngram: viat/e1: args2Role-mention-ngram: induced activationtee2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controllertQe2: trigger-arg-path: induced:Positive_regulation >nsubj >nn Gene_or_gene_productt-e1: args2Role-mention-ngram: via AMPK inducedt?e1: trigger-arg-path: inhibits >nsubj [lemma='this'] controllert.e1: args2Role-mention-ngram: mTORC1 signallingt4e1: ents2Label-mention-ngram: and phosphorylation oftAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT signalling viatNe1: trigger-arg-path: Negative_regulation >nsubj [lemma='this'] Generic_entityt5e1: ents2Label-mention-ngram: GENERIC_ENTITY inhibitstSe1: trigger-arg-path: inhibits:Negative_regulation >nsubj controller:Generic_entityt/e1: args2Role-mention-ngram: activation of TSC2tze2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mtorc1'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: 40 S ribosomalt@e1: ents2Label-mention-ngram: and represses GENE_OR_GENE_PRODUCTt'e1: ents2Label-mention-ngram: activatest'e1: ents2Label-mention-ngram: repressestDe2: trigger-arg-path: phosphorylates >nsubj >nn Gene_or_gene_productt$e1: ents2Label-mention-ngram: the 40t.e1: ents2Label-mention-ngram: ribosomal SHAREDt.e1: args2Role-mention-ngram: S6 phosphorylatest)e2: ents2Label-mention-ngram: S ribosomalt>e1: ents2Label-mention-ngram: represses GENE_OR_GENE_PRODUCT ,tCe1: trigger-arg-path: activates nsubj controlled:Bindingt0e1: ents2Label-mention-ngram: with and repressest?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] Gene_or_gene_productte1: args2Role-mention-ngram: S6t&e1: args2Role-mention-ngram: ribosomalt#e1: args2Role-mention-ngram: p70 S6t.e1: args2Role-mention-ngram: and activates thet*e2: args2Role-mention-ngram: CONTROLLER S6t$e2: ents2Label-mention-ngram: the 40t2e1: args2Role-mention-ngram: S6 phosphorylates andtce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttdobj controllert!e1: args2Role-mention-ngram: 40 St_e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj controllert e2: ents2Label-mention-ngram: S6t e1: ents2Label-mention-ngram: not\e1: trigger-arg-path: activates nsubj [lemma='4e-bp1'] Bindingt8e1: trigger-arg-path: activates nsubj Bindingt+e2: ents2Label-mention-ngram: activates thet?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj [lemma='4e-bp1'] BindingtWe1: trigger-arg-path: activates:Positive_regulation nsubj controlled:Bindingtde2: trigger-arg-path: Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] Gene_or_gene_producttxe1: trigger-arg-path: activates:Positive_regulation dobj [lemma='protein'] controllert?e1: trigger-arg-path: activates:Positive_regulation dobj [lemma='protein'] controller:Generic_entityt2e1: args2Role-mention-ngram: p70 S6 phosphorylatesthe1: trigger-arg-path: activates dobj [lemma='protein'] Generic_entityt4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ,t_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn controllert?trigger-to-trigger-path: e1:activates:Positive_regulation nsubj [lemma='s6'] >nn [lemma='p70'] controller:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='s6'] >nn [lemma='p70'] controllertEe1: trigger-arg-path: Positive_regulation nsubj controlledtge1: trigger-arg-path: activates nsubj [lemma='4e-bp1'] controlled:Bindingt3e1: ents2Label-mention-ngram: p70 S6 phosphorylatestSe1: trigger-arg-path: Positive_regulation dobj controller:Generic_entityt&e1: args2Role-mention-ngram: , and p70tLe1: trigger-arg-path: activates:Positive_regulation nsubj Bindingte2: args2Role-mention-ngram: S6tNe1: trigger-arg-path: activates:Positive_regulation dobj controllertRe1: trigger-arg-path: activates:Positive_regulation dobj Generic_entityte2: incoming: nsubj controlled:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj [lemma='protein'] controllert)e1: ents2Label-mention-ngram: S ribosomalt:e1: ents2Label-mention-ngram: phosphorylates and activatest_e2: trigger-arg-path: phosphorylates >nsubj [lemma='s6'] >nn [lemma='p70'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED no longertje2: trigger-arg-path: phosphorylates >nsubj [lemma='s6'] >nn [lemma='p70'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: the 40t'e1: args2Role-mention-ngram: and p70 S6t.e1: ents2Label-mention-ngram: activates the 40t3e2: ents2Label-mention-ngram: S6 phosphorylates andtitrigger-to-trigger-path: e1:activates:Positive_regulation nsubj controlled:Bindingt&e2: ents2Label-mention-ngram: the 40 St/e1: ents2Label-mention-ngram: and activates thetUe2: trigger-arg-path: phosphorylates >nsubj [lemma='s6'] >nn [lemma='p70'] controllertxe1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='4e-bp1'] controlled:Bindingt e1: ents2Label-mention-ngram: 40t]e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj Bindingt:e1: trigger-arg-path: activates dobj controllertLe1: trigger-arg-path: lemmatizedTrigger=activate nsubj controlledte1: incoming: dobj [lemma='protein'] Generic_entityt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , andt/e1: args2Role-mention-ngram: phosphorylates andtOe1: trigger-arg-path: activates:Positive_regulation nsubj controlledt/e1: ents2Label-mention-ngram: S6 phosphorylatest'e1: ents2Label-mention-ngram: no longert+e1: ents2Label-mention-ngram: activates thetHe1: trigger-arg-path: Positive_regulation dobj Generic_entityt!e1: ents2Label-mention-ngram: p70t]e1: trigger-arg-path: activates:Positive_regulation dobj controller:Generic_entityt%e1: args2Role-mention-ngram: the 40 St+e1: ents2Label-mention-ngram: and represseste1: trigger: activatestZe2: trigger-arg-path: Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] controllertNe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn controllert+e1: ents2Label-mention-ngram: and activateste1: args2Role-mention-ngram: St>e1: trigger-arg-path: activates dobj Generic_entitytde1: trigger-arg-path: activates dobj [lemma='protein'] controllert'e1: ents2Label-mention-ngram: , and p70t}e1: trigger-arg-path: Positive_regulation dobj [lemma='protein'] controller:Generic_entityt{e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='s6'] >nn [lemma='p70'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: S ribosomaltme1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='4e-bp1'] Bindingt&e1: ents2Label-mention-ngram: the 40 St e2: ents2Label-mention-ngram: 40te1: args2Role-mention-ngram: 40t?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj [lemma='protein'] Generic_entityt1e1: ents2Label-mention-ngram: no longer interactstte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate dobj [lemma='protein'] controller:Generic_entityt+e1: args2Role-mention-ngram: phosphorylatest?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj [lemma='protein'] controller:Generic_entityt-e1: args2Role-mention-ngram: activates the 40t.e1: ents2Label-mention-ngram: longer interactstqe1: trigger-arg-path: Positive_regulation nsubj [lemma='4e-bp1'] controlled:Bindingtpe1: trigger-arg-path: activates:Positive_regulation nsubj [lemma='4e-bp1'] BindingtOe2: trigger-arg-path: phosphorylates >nsubj >nn controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: , andtpe1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='4e-bp1'] controlledtse2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] Gene_or_gene_producttBe1: trigger-arg-path: Positive_regulation nsubj BindingtOe1: trigger-arg-path: lemmatizedTrigger=activate dobj Generic_entityt5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT S6t~e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: 40 S ribosomalt0e1: ents2Label-mention-ngram: S ribosomal SHAREDt`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn controller:Gene_or_gene_productt{e1: trigger-arg-path: activates:Positive_regulation nsubj [lemma='4e-bp1'] controlled:Bindingt"e1: ents2Label-mention-ngram: 40 StIe1: trigger-arg-path: activates dobj controller:Generic_entitytre1: trigger-arg-path: Positive_regulation dobj [lemma='protein'] Generic_entityt*e1: args2Role-mention-ngram: activates thet$e1: args2Role-mention-ngram: and p70t1e1: args2Role-mention-ngram: ribosomal CONTROLLERtUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn Gene_or_gene_producttkshortest-path: conj_and [lemma='activate'] >nsubj [lemma='s6'] >nn [lemma='p70']tze2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] controllertZe1: trigger-arg-path: lemmatizedTrigger=activate dobj controller:Generic_entityt:e2: trigger-arg-path: phosphorylates >nsubj >nn controllert9e1: args2Role-mention-ngram: phosphorylates and activatestce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj Generic_entityt3e1: args2Role-mention-ngram: S ribosomal CONTROLLERtoe2: trigger-arg-path: Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: ribosomal SHAREDt$e1: ents2Label-mention-ngram: longert?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj [lemma='4e-bp1'] controlled:Bindingtfe1: trigger-arg-path: Positive_regulation nsubj [lemma='4e-bp1'] Bindingt/e2: ents2Label-mention-ngram: and activates thetse1: trigger-arg-path: activates dobj [lemma='protein'] controller:Generic_entityt`e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj controlledtKe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn controllert'e1: ents2Label-mention-ngram: SHARED not e1: args2Role-mention-ngram: p70t"e2: ents2Label-mention-ngram: 40 St$e1: ents2Label-mention-ngram: p70 S6t0e2: ents2Label-mention-ngram: S ribosomal SHAREDtne1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation dobj controller:Generic_entityt'e2: ents2Label-mention-ngram: ribosomalt.e2: ents2Label-mention-ngram: activates the 40tie1: trigger-arg-path: Positive_regulation nsubj [lemma='4e-bp1'] controlledt;e1: trigger-arg-path: activates nsubj controlledt)e1: args2Role-mention-ngram: CONTROLLED ,tDe1: trigger-arg-path: Positive_regulation dobj controllert&e1: args2Role-mention-ngram: activatest?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj [lemma='4e-bp1'] controlledt-e1: args2Role-mention-ngram: CONTROLLED , andtIe1: trigger-arg-path: lemmatizedTrigger=activate nsubj Bindingt%e1: ents2Label-mention-ngram: and p70tue1: trigger-arg-path: lemmatizedTrigger=activate dobj [lemma='protein'] controllertXe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn Gene_or_gene_producttDe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT S6 phosphorylatestye1: trigger-arg-path: lemmatizedTrigger=activate dobj [lemma='protein'] Generic_entityt/e2: ents2Label-mention-ngram: S6 phosphorylatesthe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation nsubj controlled:Bindingtse1: trigger-arg-path: activates:Positive_regulation nsubj [lemma='4e-bp1'] controlledtpe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='s6'] >nn [lemma='p70'] Gene_or_gene_producttne1: trigger-arg-path: Positive_regulation dobj [lemma='protein'] controllert_e1: trigger-arg-path: activates nsubj [lemma='4e-bp1'] controlledt e1: ents2Label-mention-ngram: S6t*e1: args2Role-mention-ngram: and activatest*shortest-path: conj_and >nsubj >nntie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn Gene_or_gene_producttie2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='s6'] >nn [lemma='p70'] controllertXe2: trigger-arg-path: contribute >prep_to [lemma='recruitment'] controlled:Generic_eventtpe2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to [lemma='recruitment'] controlledt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shc'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: signaling ,tAe2: trigger-arg-path: contribute nsubj [lemma='ir'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=contribute nsubj [lemma='ir'] themet3e2: args2Role-mention-ngram: Shc dependent pathwayst0e2: args2Role-mention-ngram: membrane CONTROLLEDt"e2: args2Role-mention-ngram: , thet%e2: ents2Label-mention-ngram: the Shct&interceding-token ngrams: low efficacyt#e2: args2Role-mention-ngram: in EGFt&e2: args2Role-mention-ngram: signalingt^e2: trigger-arg-path: contribute:Positive_regulation >prep_to [lemma='recruitment'] controlledt@e2: trigger-arg-path: Positive_regulation >prep_to Generic_eventt+e2: ents2Label-mention-ngram: Shc dependenttBe2: trigger-arg-path: contribute >prep_to controlled:Generic_eventt*e2: ents2Label-mention-ngram: the Grb2-SOStFe1: trigger-arg-path: Binding >dobj [lemma='shc'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to [lemma='recruitment'] Generic_eventt4e2: trigger-arg-path: contribute >prep_to controlledtle2: trigger-arg-path: contribute:Positive_regulation >prep_to [lemma='recruitment'] controlled:Generic_eventtDe1: trigger-arg-path: binds >nsubj [lemma='ir'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation nsubj [lemma='ir'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: EGF signalingt'e2: ents2Label-mention-ngram: , whereastEe1: ents2Label-mention-ngram: and phosphorylates GENE_OR_GENE_PRODUCTt'interceding-token ngrams: compared witht&e2: args2Role-mention-ngram: , whereastae2: trigger-arg-path: contribute:Positive_regulation >prep_to [lemma='recruitment'] Generic_eventt.e2: args2Role-mention-ngram: the Shc dependentte2: outgoing: >advmodt#e2: ents2Label-mention-ngram: , thetBinterceding-tokens-full-span: with very low efficacy compared witht%e2: args2Role-mention-ngram: pathwaystVe2: trigger-arg-path: contribute:Positive_regulation >prep_to controlled:Generic_eventt-e2: args2Role-mention-ngram: in EGF signalingt3e2: ents2Label-mention-ngram: the Grb2-SOS membranetce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='shc'] theme:Gene_or_gene_producttMe2: trigger-arg-path: contribute >prep_to [lemma='recruitment'] Generic_eventtge2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation dobj [lemma='shc'] Gene_or_gene_producttPe2: trigger-arg-path: contribute:Positive_regulation dobj [lemma='shc'] Gene_or_gene_producttFe2: trigger-arg-path: contribute:Positive_regulation nsubj [lemma='ir'] themethe2: trigger-arg-path: lemmatizedTrigger=contribute nsubj [lemma='ir'] themetje2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to [lemma='recruitment'] controlled:Generic_eventt.e2: ents2Label-mention-ngram: substantially tot)e2: args2Role-mention-ngram: the Grb2-SOStFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ir'] themet6e2: ents2Label-mention-ngram: contribute substantiallyt e2: args2Role-mention-ngram: EGFt,e2: args2Role-mention-ngram: signaling , thet'e2: args2Role-mention-ngram: whereas intqe2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation prep_to [lemma='recruitment'] controlled:Generic_eventt_e2: trigger-arg-path: Positive_regulation prep_to controlled:Generic_eventt]e2: trigger-arg-path: lemmatizedTrigger=contribute nsubj [lemma='ir'] theme:Gene_or_gene_producttinterceding-token ngrams: veryt'e2: ents2Label-mention-ngram: dependentt(e2: ents2Label-mention-ngram: contributetprep_to controlledte2: trigger: contributet&e2: args2Role-mention-ngram: , the Shct:e2: args2Role-mention-ngram: dependent pathways contributetVe2: trigger-arg-path: contribute dobj [lemma='shc'] themetFe2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to controlledt!e2: ents2Label-mention-ngram: Shct5e1: trigger-arg-path: binds >dobj [lemma='shc'] themet]e2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to Generic_eventt0e2: ents2Label-mention-ngram: dependent pathwayst"interceding-token ngrams: comparedt;e2: ents2Label-mention-ngram: dependent pathways contributet[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ir'] theme:Gene_or_gene_productt0interceding-token ngrams: efficacy compared withtje2: trigger-arg-path: contribute:Positive_regulation dobj >prep_with >pobjt4e2: ents2Label-mention-ngram: Shc dependent pathwayst5e2: args2Role-mention-ngram: contribute substantiallyt;e2: ents2Label-mention-ngram: Grb2-SOS membrane recruitmentt\e2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to [lemma='recruitment'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to [lemma='recruitment'] Generic_eventt/e2: args2Role-mention-ngram: dependent pathwaystLe1: trigger-arg-path: Binding >nsubj [lemma='ir'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER , whereastZe2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to controlledtkshortest-path: dobj [lemma='shc'] >prep_with [lemma='efficacy'] >pobj [lemma='egfr']t,e2: ents2Label-mention-ngram: whereas in EGFt7e2: trigger-arg-path: contribute >prep_to Generic_eventt1e2: ents2Label-mention-ngram: pathways contributet'interceding-token ngrams: with very lowt%e2: ents2Label-mention-ngram: whereast[e2: trigger-arg-path: contribute:Positive_regulation dobj [lemma='shc'] themetIe2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to Generic_eventt%e2: args2Role-mention-ngram: Grb2-SOSt e2: args2Role-mention-ngram: ShctYe2: trigger-arg-path: lemmatizedTrigger=contribute dobj [lemma='shc'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >dobj [lemma='shc'] theme:Gene_or_gene_productt?e2: ents2Label-mention-ngram: pathways contribute substantiallyt>e2: args2Role-mention-ngram: pathways contribute substantiallyt2e2: args2Role-mention-ngram: the Grb2-SOS membranetTe2: trigger-arg-path: lemmatizedTrigger=contribute >prep_to controlled:Generic_eventt6e1: ents2Label-mention-ngram: binds and phosphorylatest=e2: trigger-arg-path: Positive_regulation >prep_to controlledt1e1: args2Role-mention-ngram: phosphorylates THEMEt~e2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to [lemma='recruitment'] controlled:Generic_eventtitrigger-to-trigger-path: e1:binds:Binding >dobj >prep_with >pobj >rcmod e2:contribute:Positive_regulationt/e2: ents2Label-mention-ngram: Grb2-SOS membranetUe2: trigger-arg-path: contribute:Positive_regulation dobj [lemma='shc'] themetbe2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation prep_to [lemma='recruitment'] controlledtLe1: trigger-arg-path: binds:Binding >nsubj [lemma='ir'] Gene_or_gene_productt*e2: args2Role-mention-ngram: substantiallyt$e2: ents2Label-mention-ngram: in EGFt+e2: args2Role-mention-ngram: whereas in EGFt/interceding-token ngrams: low efficacy comparedtKe2: trigger-arg-path: contribute:Positive_regulation >prep_to Generic_eventtTe2: trigger-arg-path: Positive_regulation prep_to [lemma='recruitment'] Generic_eventtJe1: trigger-arg-path: binds >nsubj [lemma='ir'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: EGF signaling ,t5e1: args2Role-mention-ngram: binds and phosphorylatest,e1: args2Role-mention-ngram: THEME binds andt'e2: ents2Label-mention-ngram: signalingt?trigger-to-trigger-path: e1:binds:Binding >dobj [lemma='shc'] >prep_with [lemma='efficacy'] >pobj [lemma='egfr'] >rcmod [lemma='contribute'] e2:contribute:Positive_regulationt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ir'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=contribute:Positive_regulation >prep_to controlled:Generic_eventtKe2: trigger-arg-path: contribute nsubj [lemma='ir'] themet*e2: args2Role-mention-ngram: Shc dependenttLe1: trigger-arg-path: Binding >dobj [lemma='shc'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: to the Grb2-SOSt$e2: args2Role-mention-ngram: whereastNe2: trigger-arg-path: lemmatizedTrigger=contribute prep_to [lemma='recruitment'] controlledt9e2: args2Role-mention-ngram: Grb2-SOS membrane CONTROLLEDtFe1: trigger-arg-path: Binding >nsubj [lemma='ir'] Gene_or_gene_productt*e2: args2Role-mention-ngram: EGF signalingtDe2: trigger-arg-path: lemmatizedTrigger=contribute dobj [lemma='shc'] themet"interceding-token ngrams: efficacyt/e1: args2Role-mention-ngram: and phosphorylatest0e2: args2Role-mention-ngram: pathways contributetJe1: trigger-arg-path: binds >dobj [lemma='shc'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bindst1e2: args2Role-mention-ngram: substantially to thetLe1: trigger-arg-path: binds:Binding >dobj [lemma='shc'] Gene_or_gene_productt0e1: args2Role-mention-ngram: not associated witht&e1: ents2Label-mention-ngram: with thetYe2: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] Gene_or_gene_productt0e2: args2Role-mention-ngram: associated with thetWe2: trigger-arg-path: associated >prep_with [lemma='igf-1r'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass Gene_or_gene_producttYe1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] themetJe1: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] themetJe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass themetbe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass themetCshortest-path: auxpass [lemma='be']tFe1: trigger-arg-path: associated >prep_with theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: was nottQe2: trigger-arg-path: associated >prep_with [lemma='igf-1r'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] Gene_or_gene_productt?e1: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] themet_e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with theme:Gene_or_gene_producttHe2: trigger-arg-path: associated:Binding >prep_with Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] themetSe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] themet?e2: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] themet1e2: trigger-arg-path: associated >prep_with themet,e2: ents2Label-mention-ngram: not associatedt$e1: args2Role-mention-ngram: was nottWe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: not associatedtje2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: was not associatedt9e1: trigger-arg-path: associated:Binding >nsubjpass themet0e2: args2Role-mention-ngram: not associated withtNe2: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] Gene_or_gene_producttFe2: trigger-arg-path: associated >nsubjpass theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with themet@e1: trigger-arg-path: associated >prep_with Gene_or_gene_productt/e1: args2Role-mention-ngram: was not associatedt[e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] themet_e1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass Gene_or_gene_productte1: trigger: associatedtTe2: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: with the SHAREDt?e2: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] themet-e2: ents2Label-mention-ngram: associated witht@e2: trigger-arg-path: associated >nsubjpass Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: with the THEMEt,e1: args2Role-mention-ngram: associated withtSe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] themet%e1: ents2Label-mention-ngram: was nottHe1: trigger-arg-path: associated:Binding >prep_with Gene_or_gene_producttFe2: trigger-arg-path: associated >prep_with theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: associated with thetWe2: trigger-arg-path: associated >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttQe1: trigger-arg-path: associated >prep_with [lemma='igf-1r'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_producttNe1: trigger-arg-path: associated:Binding >nsubjpass theme:Gene_or_gene_productt1e1: trigger-arg-path: associated >nsubjpass themet$e2: args2Role-mention-ngram: was nott_e2: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_producttWe1: trigger-arg-path: associated >prep_with [lemma='igf-1r'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: associated witht+e1: args2Role-mention-ngram: not associatedtYe1: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass themet'e2: args2Role-mention-ngram: associatedtWe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with theme:Gene_or_gene_producttJe2: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] themetje2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED was nottNe2: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] Gene_or_gene_productt&e2: args2Role-mention-ngram: the THEMEtQe2: trigger-arg-path: associated >nsubjpass [lemma='galpha'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttHe2: trigger-arg-path: associated:Binding >nsubjpass Gene_or_gene_productt/e2: args2Role-mention-ngram: was not associatedtNe1: trigger-arg-path: associated:Binding >prep_with theme:Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass themetSe2: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galpha'] themetNe2: trigger-arg-path: associated:Binding >nsubjpass theme:Gene_or_gene_producttBe1: trigger-arg-path: associated >nsubjpass [lemma='galpha'] themet%e2: args2Role-mention-ngram: with thetBe2: trigger-arg-path: associated >nsubjpass [lemma='galpha'] themetYe2: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] Gene_or_gene_productt@e1: trigger-arg-path: associated >nsubjpass Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass Gene_or_gene_productt1e1: ents2Label-mention-ngram: not associated witht9e1: trigger-arg-path: associated:Binding >prep_with themet9e2: trigger-arg-path: associated:Binding >nsubjpass themet-e1: ents2Label-mention-ngram: associated withte2: trigger: associatedt0e2: ents2Label-mention-ngram: was not associatedt-e1: ents2Label-mention-ngram: with the SHAREDtbe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] Gene_or_gene_productt+e1: args2Role-mention-ngram: with the THEMEt1e2: ents2Label-mention-ngram: associated with thetJe1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] themetBe2: trigger-arg-path: associated >prep_with [lemma='igf-1r'] themetJe2: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] themetFe1: trigger-arg-path: associated >nsubjpass theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] Gene_or_gene_producttQe1: trigger-arg-path: associated >nsubjpass [lemma='galpha'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: associated with thetNe2: trigger-arg-path: associated:Binding >prep_with theme:Gene_or_gene_producttTe2: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: with thet*e1: args2Role-mention-ngram: THEME was nottBe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with themetHe1: trigger-arg-path: associated:Binding >nsubjpass Gene_or_gene_productt'e1: args2Role-mention-ngram: associatedtQe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] themet*e2: args2Role-mention-ngram: THEME was nott1e2: trigger-arg-path: associated >nsubjpass themet1e1: trigger-arg-path: associated >prep_with themet,e1: ents2Label-mention-ngram: not associatedt[e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] themetpe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] themet,e2: ents2Label-mention-ngram: SHARED was nottWe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass theme:Gene_or_gene_productt_e1: trigger-arg-path: associated:Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_producttBe1: trigger-arg-path: associated >prep_with [lemma='igf-1r'] themet_e2: trigger-arg-path: associated:Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_productt1e2: ents2Label-mention-ngram: not associated withtWe1: trigger-arg-path: associated >nsubjpass [lemma='galpha'] theme:Gene_or_gene_producttTe1: trigger-arg-path: Binding >nsubjpass [lemma='galpha'] theme:Gene_or_gene_productt9e2: trigger-arg-path: associated:Binding >prep_with themet%e1: args2Role-mention-ngram: with thet@e2: trigger-arg-path: associated >prep_with Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='igf-1r'] theme:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='igf-1r'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >conj_and >dobj theme:Gene_or_gene_productt3e1: trigger-arg-path: Binding >conj_and >dobj themetfe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] Gene_or_gene_productte1: ents2Label-mention-ngram: 9t.e2: ents2Label-mention-ngram: SHARED at Lys233tce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >conj_and >prep_at site:Sitet,e2: ents2Label-mention-ngram: and methylatest]e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj Gene_or_gene_productt2e2: ents2Label-mention-ngram: methylates SHARED attLe1: trigger-arg-path: interacts:Binding >conj_and >dobj Gene_or_gene_producttde1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] Sitet/e1: ents2Label-mention-ngram: methylates SHAREDtje1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] themet1e1: args2Role-mention-ngram: and methylates THEMEt'e2: ents2Label-mention-ngram: at Lys233t)e2: ents2Label-mention-ngram: 9 interactst_e1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] site:Sitet.e2: ents2Label-mention-ngram: 9 interacts witht&e1: args2Role-mention-ngram: at Lys233t?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] theme:Gene_or_gene_productte2: ents2Label-mention-ngram: 9te1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts:Binding >conj_and >prep_at sitet3e2: args2Role-mention-ngram: CONTROLLER 9 interactst)e1: ents2Label-mention-ngram: at Lys233 ,tre1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] site:Sitet7e1: trigger-arg-path: interacts >conj_and >prep_at sitet&e2: ents2Label-mention-ngram: , Lys235t0e2: args2Role-mention-ngram: with and CONTROLLEDt0e1: ents2Label-mention-ngram: SHARED 9 interactstBe1: trigger-arg-path: Binding >conj_and >dobj Gene_or_gene_producttDe1: trigger-arg-path: interacts >conj_and >dobj Gene_or_gene_productt$e1: ents2Label-mention-ngram: Lys233tne1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] sitete1: args2Role-mention-ngram: 9t=e1: trigger-arg-path: interacts:Binding >conj_and >dobj themete1: args2Role-mention-ngram: attZe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] sitet?e1: trigger-arg-path: interacts:Binding >conj_and >prep_at Sitet5e1: trigger-arg-path: interacts >conj_and >dobj themet+e1: args2Role-mention-ngram: and methylatest[e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: Lys233 , Lys235t2e1: ents2Label-mention-ngram: methylates SHARED att(e2: args2Role-mention-ngram: 9 interactst/e2: ents2Label-mention-ngram: methylates SHAREDtae1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] site:Sitet&e1: ents2Label-mention-ngram: , Lys235t(e2: ents2Label-mention-ngram: methylatest(e1: args2Role-mention-ngram: at Lys233 ,tue1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] sitet)e1: ents2Label-mention-ngram: 9 interactstUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at site:Sitetye1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] Gene_or_gene_productte2: trigger: methylatest)e2: args2Role-mention-ngram: CONTROLLER 9t'e1: ents2Label-mention-ngram: at Lys233t.e1: ents2Label-mention-ngram: SHARED at Lys233t5e1: trigger-arg-path: Binding >conj_and >prep_at sitetYtrigger-to-trigger-path: e1:interacts:Binding >conj_and e2:methylates:Positive_regulationtZe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] Sitet$e2: ents2Label-mention-ngram: Lys233t0e2: ents2Label-mention-ngram: SHARED 9 interactstme1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] Sitet#e1: args2Role-mention-ngram: , SITEt%e1: args2Role-mention-ngram: THEME attve1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] theme:Gene_or_gene_producttpe1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: Lys235t-e2: args2Role-mention-ngram: 9 interacts witht#e1: args2Role-mention-ngram: Lys233tPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at sitetie1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] site:Sitet$e1: args2Role-mention-ngram: THEME 9t.e1: ents2Label-mention-ngram: 9 interacts withtue1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] Sitet7e1: trigger-arg-path: interacts >conj_and >prep_at Sitet%e1: args2Role-mention-ngram: Lys233 ,t&e2: ents2Label-mention-ngram: SHARED 9t1e1: ents2Label-mention-ngram: with and methylatestHe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at sitet(e1: ents2Label-mention-ngram: methylatestle1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] themet(e1: args2Role-mention-ngram: 9 interactst&e2: ents2Label-mention-ngram: Lys233 ,tYe1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] themet0e1: args2Role-mention-ngram: with and methylatestmtrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='methylate'] e2:methylates:Positive_regulationtJe1: trigger-arg-path: interacts >conj_and >dobj theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >prep_at Sitet-e1: ents2Label-mention-ngram: Lys233 , Lys235tde1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] sitet$e2: ents2Label-mention-ngram: Lys235t.e1: args2Role-mention-ngram: THEME 9 interactst*e1: args2Role-mention-ngram: Lys233 , SITEt0e1: args2Role-mention-ngram: methylates THEME att'e1: args2Role-mention-ngram: methylatest&e1: ents2Label-mention-ngram: SHARED 9t,e1: ents2Label-mention-ngram: and methylatest\e1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] sitetHe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at Sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] Gene_or_gene_producttDe1: trigger-arg-path: interacts:Binding >conj_and >prep_at site:Sitet&e1: ents2Label-mention-ngram: Lys233 ,t,e1: args2Role-mention-ngram: THEME at Lys233the1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] Gene_or_gene_productt-e1: args2Role-mention-ngram: 9 interacts witht1e2: ents2Label-mention-ngram: with and methylatest5e1: trigger-arg-path: Binding >conj_and >prep_at Sitete1: SITE: 2tae1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] themetFe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj themetconj_and >prep_at site:Sitet)e2: ents2Label-mention-ngram: at Lys233 ,tMe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >prep_at site:Sitet-e1: args2Role-mention-ngram: methylates THEMEtze1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] site:Sitete2: args2Role-mention-ngram: 9tWe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='sirt1'] themet3e2: ents2Label-mention-ngram: and methylates SHAREDtNe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj themet3e1: ents2Label-mention-ngram: and methylates SHAREDt\e1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >prep_at [lemma='lys235'] SitetUe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj Gene_or_gene_producttHe1: trigger-arg-path: Binding >conj_and >dobj theme:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=increase >dobj controlledt.e1: ents2Label-mention-ngram: did not increaset?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] Gene_or_gene_productte1: trigger: increasetSe1: trigger-arg-path: increase:Positive_regulation >dobj controlled:Phosphorylationtee1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj controlled:Phosphorylationt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='igf2'] controller:Gene_or_gene_productt:e2: trigger-arg-path: induced >nsubj >prep_with controllertXe2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_with Gene_or_gene_producttSe1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='igf2'] controllertee1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='igf2'] controllert_e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_with controllert}e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtatrigger-to-trigger-path: e1:increase:Positive_regulation >conj_but e2:induced:Positive_regulationt0interceding-token ngrams: but pre-treatment withtUe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_with Gene_or_gene_producttYe1: trigger-arg-path: increase:Positive_regulation >nsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='igf2'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: increase >dobj controlled:Phosphorylationtze2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controllertHe1: trigger-arg-path: increase:Positive_regulation >dobj Phosphorylationt*e1: ents2Label-mention-ngram: not increasetNe1: trigger-arg-path: increase:Positive_regulation >nsubj Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj Phosphorylationtnsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controllert1e1: ents2Label-mention-ngram: not increase SHAREDt[e1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: increase >nsubj [lemma='igf2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] Phosphorylationt-e1: ents2Label-mention-ngram: increase SHAREDt:e1: trigger-arg-path: increase >nsubj Gene_or_gene_producttfe2: trigger-arg-path: induced >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controllertHe2: trigger-arg-path: induced >dobj [lemma='phosphorylation'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controller:Gene_or_gene_producttPe2: trigger-arg-path: Positive_regulation >nsubj >prep_with Gene_or_gene_productt+e1: args2Role-mention-ngram: CONTROLLER didt e1: args2Role-mention-ngram: didtfe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='igf2'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: did not increaset`e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_with controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationtae2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationthe1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='igf2'] controller:Gene_or_gene_producttEe1: trigger-arg-path: increase >nsubj controller:Gene_or_gene_producttMe2: trigger-arg-path: induced >dobj [lemma='phosphorylation'] Phosphorylationt*interceding-token ngrams: over controls intme1: trigger-arg-path: increase:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtrtrigger-to-trigger-path: e1:increase:Positive_regulation >conj_but [lemma='induce'] e2:induced:Positive_regulationt4e2: ents2Label-mention-ngram: SHARED phosphorylationt%interceding-token ngrams: controls intie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_with Gene_or_gene_producttinterceding-token ngrams: overtre2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtXe2: trigger-arg-path: induced >dobj [lemma='phosphorylation'] controlled:Phosphorylationt4e1: args2Role-mention-ngram: not increase CONTROLLEDtce2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_with controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: did nott$e1: args2Role-mention-ngram: did nottte2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_with controller:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj controlledt'interceding-token ngrams: in Huh7 cellstFe1: trigger-arg-path: lemmatizedTrigger=increase >dobj PhosphorylationtWe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj controller:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controllertbe1: trigger-arg-path: increase:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt/e1: trigger-arg-path: increase >dobj controlledt1shortest-path: conj_but >nsubj >prep_withtoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='igf2'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:PhosphorylationtOe2: trigger-arg-path: induced >nsubj >prep_with controller:Gene_or_gene_producttYe1: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationtpe2: trigger-arg-path: induced >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='igf2'] controllert1interceding-token ngrams: cells but pre-treatmentt?shortest-path: conj_but [lemma='induce'] >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib']t`e1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] Phosphorylationt6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT didt'interceding-token ngrams: pre-treatmenttFe2: trigger-arg-path: Positive_regulation >nsubj >prep_with controllertme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] controlledt?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj Gene_or_gene_productt]e1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='igf2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controllertJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='igf2'] controllert+interceding-token ngrams: but pre-treatmentt$interceding-token ngrams: Huh7 cellstYe1: trigger-arg-path: increase >dobj [lemma='phosphorylation'] controlled:Phosphorylationt"interceding-token ngrams: controlstIe1: trigger-arg-path: increase >nsubj [lemma='igf2'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT did nott?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] Gene_or_gene_producttYe2: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt'interceding-token ngrams: over controlstie2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] controlled:Phosphorylationtre2: trigger-arg-path: Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controllertDe2: trigger-arg-path: induced >nsubj >prep_with Gene_or_gene_producttNe2: trigger-arg-path: induced:Positive_regulation >nsubj >prep_with controllertke1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] Gene_or_gene_producttde2: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt!interceding-token ngrams: in Huh7t,interceding-token ngrams: pre-treatment withtze1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='igf2'] controller:Gene_or_gene_producttTe1: trigger-arg-path: increase >nsubj [lemma='igf2'] controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='igf2'] Gene_or_gene_productt)e1: args2Role-mention-ngram: not increaset%e1: args2Role-mention-ngram: increaset!e1: ents2Label-mention-ngram: didtoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] controlledt0e1: args2Role-mention-ngram: increase CONTROLLEDt0e1: trigger-arg-path: increase >nsubj controllertTe2: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] controlledt{e2: trigger-arg-path: induced >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: increaset]e1: trigger-arg-path: increase:Positive_regulation >dobj [lemma='phosphorylation'] controlledt(interceding-token ngrams: Huh7 cells butte1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt4e1: trigger-arg-path: increase >dobj PhosphorylationtIe1: trigger-arg-path: increase >dobj [lemma='phosphorylation'] controlledt\e2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] controlledtKe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_with controllert|e2: trigger-arg-path: Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj controllert*interceding-token ngrams: controls in Huh7t#interceding-token ngrams: cells butt=e1: ents2Label-mention-ngram: increase SHARED phosphorylationtde1: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='pre-treatment'] >prep_with [lemma='salirasib'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER did nottke1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] controlled:Phosphorylationtle2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtDe1: trigger-arg-path: increase:Positive_regulation >nsubj controllert[e2: trigger-arg-path: Positive_regulation >nsubj >prep_with controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >dobj [lemma='phosphorylation'] controlledtNe1: trigger-arg-path: increase >dobj [lemma='phosphorylation'] PhosphorylationtPinterceding-tokens-full-span: over controls in Huh7 cells but pre-treatment withtCe1: trigger-arg-path: increase:Positive_regulation >dobj controlledt*e2: ents2Label-mention-ngram: nerve SHAREDtJe2: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] controllertXe2: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_producttTe1: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] Gene_or_gene_productt"e2: args2Role-mention-ngram: nervetXe1: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_producttce1: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_productt#e2: ents2Label-mention-ngram: nervetie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLED by nervet0e1: args2Role-mention-ngram: by nerve CONTROLLERtbe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by controller:Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] controllert-e1: ents2Label-mention-ngram: by nerve SHAREDt,shortest-path: prep_by controllert_e1: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] controllertNe2: trigger-arg-path: phosphorylation >prep_by controller:Gene_or_gene_producttJe1: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] controllert0e2: ents2Label-mention-ngram: phosphorylation bythe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_productt^e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_producttse1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] controllertce2: trigger-arg-path: Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by controllert0e2: args2Role-mention-ngram: by nerve CONTROLLERtfe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] Gene_or_gene_productthe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_productt%e2: args2Role-mention-ngram: by nervetCe2: trigger-arg-path: phosphorylation >prep_by Gene_or_gene_productt-e2: args2Role-mention-ngram: nerve CONTROLLERt6e1: ents2Label-mention-ngram: phosphorylation by nervetpe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] controllert^e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] controllert_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by controllertUe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: by nervetWe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] controller:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] controller:Gene_or_gene_productt9e2: trigger-arg-path: phosphorylation >prep_by controllert-e1: args2Role-mention-ngram: nerve CONTROLLERt6e2: ents2Label-mention-ngram: phosphorylation by nervet%e1: args2Role-mention-ngram: by nervet_e2: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: by nervetTe2: trigger-arg-path: phosphorylation >prep_by [lemma='factor'] Gene_or_gene_productt#e1: ents2Label-mention-ngram: nervet"e1: args2Role-mention-ngram: nervet7e2: ents2Label-mention-ngram: SHARED phosphorylation byt*e1: ents2Label-mention-ngram: nerve SHAREDt\e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] controllert\e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='factor'] controllert0e1: args2Role-mention-ngram: CONTROLLED by nervet-e2: ents2Label-mention-ngram: by nerve SHAREDtze1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='factor'] Gene_or_gene_producttse2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='factor'] controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by controller:Gene_or_gene_productt%interceding-token ngrams: ERalpha andt+interceding-token ngrams: deacetylase SIRT1tVe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='histone'] controllertinterceding-token ngrams: p300the1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] Gene_or_gene_productt!interceding-token ngrams: bindingt!interceding-token ngrams: histonet&interceding-token ngrams: interferencetQe2: trigger-arg-path: Positive_regulation >nn [lemma='histone'] controller:Familyt%interceding-token ngrams: recruitmentt,e2: trigger-arg-path: acetylation >nn Familytbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productte2: trigger: acetylationt.interceding-token ngrams: Nrf2 inducible genestUe1: trigger-arg-path: Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productt0interceding-token ngrams: from interference witht%interceding-token ngrams: like NQO1 ,t$interceding-token ngrams: of ERalphat"interceding-token ngrams: SIRT1 totRe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn Familyt&interceding-token ngrams: the promotertke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn controllertPe1: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] themettrigger-to-trigger-path: e1:interactions:Binding prep_from [lemma='sirt1'] >prep_from [lemma='interference'] >prep_with [lemma='recruitment'] >vmod [lemma='lead'] >prep_to [lemma='acetylation'] e2:acetylation:Positive_regulationt#interceding-token ngrams: NQO1 , ortse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn controller:Familyt%interceding-token ngrams: the histonet_e1: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] Gene_or_gene_productt+interceding-token ngrams: interference witht interceding-token ngrams: , fromtBe2: trigger-arg-path: acetylation >nn [lemma='histone'] controllertFe2: trigger-arg-path: Positive_regulation >nn [lemma='histone'] Familyt*interceding-token ngrams: from competitivet,interceding-token ngrams: , from competitivet^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] themet?interceding-tokens-full-span: , from competitive binding of ERalpha and the histone deacetylase SIRT1 to the promoter of Nrf2 inducible genes like NQO1 , or from interference with p300 recruitment leading tot/interceding-token ngrams: with p300 recruitmenttinterceding-token ngrams: NQO1tde2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='histone'] Familyt\e1: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: acetylation oft)interceding-token ngrams: genes like NQO1t.interceding-token ngrams: inducible genes liket>e2: trigger-arg-path: lemmatizedTrigger=acetylation >nn Familyt>e2: trigger-arg-path: acetylation >nn [lemma='histone'] Familyt)interceding-token ngrams: to the promotertinterceding-token ngrams: SIRT1tYe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] themetHe1: trigger-arg-path: interactions >prep_between [lemma='eralpha'] themetinterceding-token ngrams: Nrf2t$interceding-token ngrams: binding oftinterceding-token ngrams: liket0e2: trigger-arg-path: acetylation >nn controllertVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] themet0interceding-token ngrams: interference with p300t.interceding-token ngrams: deacetylase SIRT1 tot%interceding-token ngrams: promoter oft2interceding-token ngrams: p300 recruitment leadingt2interceding-token ngrams: from competitive bindingt[e2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='histone'] controller:FamilytEe1: trigger-arg-path: interactions >prep_between [lemma='nrf2'] themetee1: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: acetylation of SHAREDtDe2: trigger-arg-path: acetylation:Positive_regulation >nn controllertRe1: trigger-arg-path: Binding >prep_between [lemma='eralpha'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='histone'] Familyt(interceding-token ngrams: of ERalpha andtTe1: trigger-arg-path: interactions >prep_between [lemma='nrf2'] Gene_or_gene_productt7e2: trigger-arg-path: acetylation >nn controller:Familyt-interceding-token ngrams: competitive bindingt$interceding-token ngrams: genes liketae1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] themet?e2: trigger-arg-path: Positive_regulation >nn controller:Familytinterceding-token ngrams: genest*interceding-token ngrams: promoter of Nrf2tWe1: trigger-arg-path: interactions >prep_between [lemma='eralpha'] Gene_or_gene_producttMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] themet@e2: trigger-arg-path: acetylation:Positive_regulation >nn FamilytKe2: trigger-arg-path: acetylation:Positive_regulation >nn controller:Familyt#interceding-token ngrams: like NQO1tpe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] Gene_or_gene_productt)interceding-token ngrams: ERalpha and thetIe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn controller:Familyt"interceding-token ngrams: promotert.interceding-token ngrams: or from interferencethe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='histone'] controllertIe2: trigger-arg-path: acetylation >nn [lemma='histone'] controller:Familyt,interceding-token ngrams: binding of ERalphat%interceding-token ngrams: competitivet=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and SHAREDt interceding-token ngrams: NQO1 ,t1interceding-token ngrams: the histone deacetylasetZe1: trigger-arg-path: interactions >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttGe1: ents2Label-mention-ngram: interactions between GENE_OR_GENE_PRODUCTt#interceding-token ngrams: induciblet*interceding-token ngrams: p300 recruitmentt?shortest-path: prep_from [lemma='sirt1'] >prep_from [lemma='interference'] >prep_with [lemma='recruitment'] >vmod [lemma='lead'] >prep_to [lemma='acetylation'] >nn [lemma='histone']t0interceding-token ngrams: recruitment leading totoe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='histone'] controller:Familytme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] Gene_or_gene_productt(interceding-token ngrams: Nrf2 inducibletRe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='histone'] Familytinterceding-token ngrams: , ort!interceding-token ngrams: of Nrf2t)interceding-token ngrams: inducible genest!interceding-token ngrams: or fromt+interceding-token ngrams: from interferencet@e1: trigger-arg-path: Binding >prep_between [lemma='nrf2'] themet&interceding-token ngrams: SIRT1 to thetMshortest-path: prep_from >prep_from >prep_with >vmod >prep_to >nnt4e2: trigger-arg-path: Positive_regulation >nn Familyt3interceding-token ngrams: histone deacetylase SIRT1tOe1: trigger-arg-path: Binding >prep_between [lemma='nrf2'] Gene_or_gene_productt#interceding-token ngrams: , or fromt)interceding-token ngrams: the promoter oft0e2: ents2Label-mention-ngram: FAMILY acetylationtJe2: trigger-arg-path: Positive_regulation >nn [lemma='histone'] controllertVe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn controllertTe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='histone'] controllert+interceding-token ngrams: of Nrf2 induciblet]e2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='histone'] controller:Familyt-interceding-token ngrams: recruitment leadingt3e2: ents2Label-mention-ngram: FAMILY acetylation oftCe1: trigger-arg-path: Binding >prep_between [lemma='eralpha'] themet%interceding-token ngrams: deacetylaset-interceding-token ngrams: histone deacetylaset?trigger-to-trigger-path: e1:interactions:Binding prep_from >prep_from >prep_with >vmod >prep_to e2:acetylation:Positive_regulationtne1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] Gene_or_gene_productt]e1: trigger-arg-path: interactions >prep_between [lemma='eralpha'] theme:Gene_or_gene_productt#interceding-token ngrams: with p300t0interceding-token ngrams: competitive binding oft)interceding-token ngrams: and the histonetje2: trigger-arg-path: lemmatizedTrigger=increase conj_and >dobj Gene_or_gene_productt(e2: args2Role-mention-ngram: , resultingt,e2: ents2Label-mention-ngram: and activationt0e1: ents2Label-mention-ngram: SHARED , resultingt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertPe1: trigger-arg-path: methylates:Positive_regulation >nsubj Gene_or_gene_productt?e2: trigger-arg-path: increased:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: SHARED ,t2e1: trigger-arg-path: methylates >nsubj controllert'e1: ents2Label-mention-ngram: resultingt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttXe2: trigger-arg-path: increased:Positive_regulation nn controlled:PhosphorylationtYe2: trigger-arg-path: increased conj_and >dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn [lemma='tyrosine'] controlled:Phosphorylationt>e2: trigger-arg-path: Positive_regulation nn controlledt\e1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj [lemma='ezh2'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: , resulting intle1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj controller:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and >dobj controllert)e1: ents2Label-mention-ngram: , resultingtJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ezh2'] controllertxe2: trigger-arg-path: increased:Positive_regulation conj_and >dobj controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=increase conj_and >dobj controllertfe1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj [lemma='ezh2'] controllertme2: trigger-arg-path: increased:Positive_regulation conj_and >dobj Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn controlledt e1: ents2Label-mention-ngram: int+e2: args2Role-mention-ngram: , resulting intze2: trigger-arg-path: increased:Positive_regulation nn [lemma='tyrosine'] Phosphorylationt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , resultingt{e2: trigger-arg-path: Positive_regulation nn [lemma='tyrosine'] controlled:Phosphorylationtre2: trigger-arg-path: lemmatizedTrigger=increase nn [lemma='tyrosine'] controlledte1: trigger: methylatest_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ezh2'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=increase nn controlled:PhosphorylationtMe2: trigger-arg-path: increased:Positive_regulation nn Phosphorylationtue2: trigger-arg-path: increased:Positive_regulation nn [lemma='tyrosine'] controlledt,e2: ents2Label-mention-ngram: , resulting int4e2: ents2Label-mention-ngram: resulting in increasedt?e2: trigger-arg-path: increased conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllert?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttVe1: trigger-arg-path: methylates >nsubj [lemma='ezh2'] controller:Gene_or_gene_producttDe2: trigger-arg-path: increased nn controlled:Phosphorylationt3e1: ents2Label-mention-ngram: in increased tyrosinetMe1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: increased conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt9e2: trigger-arg-path: increased nn Phosphorylationt~e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and >dobj Gene_or_gene_producttfe2: trigger-arg-path: increased nn [lemma='tyrosine'] PhosphorylationtFe1: trigger-arg-path: methylates:Positive_regulation >nsubj controllert_e1: trigger-arg-path: methylates:Positive_regulation >nsubj [lemma='ezh2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn [lemma='tyrosine'] controlledtCe1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn [lemma='tyrosine'] Phosphorylationtke2: trigger-arg-path: Positive_regulation nn [lemma='tyrosine'] controlledtne2: trigger-arg-path: Positive_regulation conj_and >dobj controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: in increasedt?shortest-path: dobj [lemma='stat3']t?e2: trigger-arg-path: increased:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ezh2'] Gene_or_gene_producttKe1: trigger-arg-path: methylates >nsubj [lemma='ezh2'] Gene_or_gene_producttqe2: trigger-arg-path: increased nn [lemma='tyrosine'] controlled:PhosphorylationtAe1: trigger-arg-path: methylates >nsubj [lemma='ezh2'] controllert*e1: ents2Label-mention-ngram: resulting int?e2: trigger-arg-path: lemmatizedTrigger=increase nn [lemma='tyrosine'] controlled:Phosphorylationt?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: and activation oft3e2: ents2Label-mention-ngram: in increased tyrosinetAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interacts withtRe1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj [lemma='ezh2'] controllert*e2: ents2Label-mention-ngram: in increasedt4e2: trigger-arg-path: increased nn controlledtwe2: trigger-arg-path: lemmatizedTrigger=increase nn [lemma='tyrosine'] Phosphorylationt*e2: ents2Label-mention-ngram: resulting int?trigger-to-trigger-path: e1:methylates:Positive_regulation vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >amod [lemma='increase'] e2:increased:Positive_regulationt[e1: trigger-arg-path: methylates:Positive_regulation >nsubj controller:Gene_or_gene_producttpe2: trigger-arg-path: Positive_regulation nn [lemma='tyrosine'] Phosphorylationt?e2: trigger-arg-path: increased conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation conj_and >dobj controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn Phosphorylationt{e1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj [lemma='ezh2'] controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nn controlled:PhosphorylationtCe2: trigger-arg-path: Positive_regulation nn Phosphorylationtge1: trigger-arg-path: lemmatizedTrigger=methylate >nsubj [lemma='ezh2'] controller:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj controllertpe1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj [lemma='ezh2'] Gene_or_gene_producttHe2: trigger-arg-path: increased:Positive_regulation nn controlledtJe2: trigger-arg-path: lemmatizedTrigger=increase nn Phosphorylationtde2: trigger-arg-path: increased conj_and >dobj controller:Gene_or_gene_producttce2: trigger-arg-path: increased:Positive_regulation conj_and >dobj controllert3e2: args2Role-mention-ngram: resulting in increasedt?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertEe2: trigger-arg-path: lemmatizedTrigger=increase nn controlledt)e2: args2Role-mention-ngram: in increasedt'e2: ents2Label-mention-ngram: resultingtnsubj Gene_or_gene_productt4e2: args2Role-mention-ngram: in increased CONTROLLEDtOe2: trigger-arg-path: increased conj_and >dobj controllert?e2: trigger-arg-path: increased:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: resulting in increasedte2: CONTROLLER: 5tztrigger-to-trigger-path: e1:methylates:Positive_regulation vmod >prep_in >amod e2:increased:Positive_regulationtYe2: trigger-arg-path: Positive_regulation conj_and >dobj controllertue2: trigger-arg-path: lemmatizedTrigger=increase conj_and >dobj controller:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation nn controlled:Phosphorylationt?e2: trigger-arg-path: increased:Positive_regulation nn [lemma='tyrosine'] controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=increase conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertce2: trigger-arg-path: Positive_regulation conj_and >dobj Gene_or_gene_producttGe1: trigger-arg-path: methylates >nsubj controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: resulting intje1: trigger-arg-path: methylates:Positive_regulation >nsubj [lemma='ezh2'] controller:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=methylate:Positive_regulation >nsubj Gene_or_gene_producttae2: trigger-arg-path: increased nn [lemma='tyrosine'] controlledtnsubj [lemma='ezh2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=increase conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLER , resultingt&e2: args2Role-mention-ngram: resultingt^e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj Gene_or_gene_productt;e1: args2Role-mention-ngram: CONTROLLER stimulation elicitstRe2: trigger-arg-path: Positive_activation >prep_of controlled:Gene_or_gene_producttPe2: trigger-arg-path: induction:Positive_activation >nn [lemma='erk'] controllert7e1: ents2Label-mention-ngram: elicits SHARED expressiontge1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='antigen'] controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: ERK1tnn [lemma='erk'] controllert,e1: ents2Label-mention-ngram: elicits SHAREDtGe2: trigger-arg-path: Positive_activation >prep_of Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj Gene_or_gene_productt3e1: args2Role-mention-ngram: CONTROLLER stimulationt@e1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj controllert(interceding-token ngrams: B-cell chronict[e2: trigger-arg-path: Positive_activation >nn [lemma='erk'] controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:elicits:Positive_regulation >dobj [lemma='phosphorylation'] >prep_in [lemma='leukemia'] >rcmod [lemma='regulate'] >nsubj [lemma='induction'] e2:induction:Positive_activationtee2: trigger-arg-path: induction:Positive_activation >nn [lemma='erk'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER dependentt0e2: args2Role-mention-ngram: dependent inductiont#e1: ents2Label-mention-ngram: and 2t&e1: ents2Label-mention-ngram: ERK1 andt:shortest-path: dobj >prep_in >rcmod >nsubj >nntPe2: trigger-arg-path: Positive_activation >nn [lemma='erk'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >prep_of [lemma='c-myc'] Gene_or_gene_productt$e1: args2Role-mention-ngram: elicitstMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='antigen'] controllertWe2: trigger-arg-path: Positive_activation >prep_of [lemma='c-myc'] Gene_or_gene_productt\e2: trigger-arg-path: induction:Positive_activation >prep_of controlled:Gene_or_gene_productt%e1: ents2Label-mention-ngram: elicitstie2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >prep_of [lemma='c-myc'] controlledtae2: trigger-arg-path: induction:Positive_activation >prep_of [lemma='c-myc'] Gene_or_gene_productte2: trigger: inductiont8e1: ents2Label-mention-ngram: stimulation elicits SHAREDt{e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj [lemma='antigen'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: and 2 phosphorylationte1: ents2Label-mention-ngram: 2tfe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj [lemma='antigen'] controllertWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='antigen'] Gene_or_gene_producttBe2: trigger-arg-path: induction:Positive_activation >nn controllertTe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj controllert0e1: args2Role-mention-ngram: stimulation elicitst_e1: trigger-arg-path: elicits:Positive_regulation >nsubj [lemma='antigen'] Gene_or_gene_productte1: incoming: e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulationtWe2: trigger-arg-path: induction:Positive_activation >nn controller:Gene_or_gene_producttMe1: trigger-arg-path: elicits:Positive_regulation >nsubj Gene_or_gene_producttHe2: trigger-arg-path: induction >prep_of controlled:Gene_or_gene_productt8e2: trigger-arg-path: Positive_activation >nn controllertle2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn [lemma='erk'] Gene_or_gene_productt4e2: args2Role-mention-ngram: induction of CONTROLLEDt*e1: ents2Label-mention-ngram: via ERK1 andt*e2: ents2Label-mention-ngram: induction oftMe2: trigger-arg-path: Positive_activation >prep_of [lemma='c-myc'] controlledt/e1: ents2Label-mention-ngram: 2 phosphorylationtne2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >prep_of controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: ERK1 and 2tUe2: trigger-arg-path: lemmatizedTrigger=induction >nn controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: inductiontCe2: trigger-arg-path: induction >nn controller:Gene_or_gene_producttQe2: trigger-arg-path: induction >nn [lemma='erk'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: inductiont;e1: args2Role-mention-ngram: stimulation elicits CONTROLLEDt3e2: args2Role-mention-ngram: dependent induction oft%interceding-token ngrams: lymphocytict1e1: ents2Label-mention-ngram: expression via ERK1t6interceding-token ngrams: chronic lymphocytic leukemiatLe2: trigger-arg-path: induction:Positive_activation >nn Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=induction >prep_of controlled:Gene_or_gene_productt&e1: ents2Label-mention-ngram: via ERK1tNe2: trigger-arg-path: lemmatizedTrigger=induction >nn [lemma='erk'] controllert0interceding-token ngrams: lymphocytic leukemia ,tce2: trigger-arg-path: lemmatizedTrigger=induction >nn [lemma='erk'] controller:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=induction >nn [lemma='erk'] Gene_or_gene_producttMe2: trigger-arg-path: induction >prep_of [lemma='c-myc'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj controller:Gene_or_gene_producttOinterceding-tokens-full-span: in B-cell chronic lymphocytic leukemia , in whicht~e2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >prep_of [lemma='c-myc'] controlled:Gene_or_gene_producttFe2: trigger-arg-path: Positive_activation >nn [lemma='erk'] controllertDe1: trigger-arg-path: elicits >nsubj controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: expression viatUe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj controller:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='antigen'] controllert;e2: args2Role-mention-ngram: CONTROLLER dependent inductiontXe2: trigger-arg-path: induction >prep_of [lemma='c-myc'] controlled:Gene_or_gene_producttVe1: trigger-arg-path: elicits >nsubj [lemma='antigen'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn [lemma='erk'] controllertFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation elicitst)e2: args2Role-mention-ngram: induction oft"interceding-token ngrams: leukemiatbe2: trigger-arg-path: Positive_activation >prep_of [lemma='c-myc'] controlled:Gene_or_gene_productt!interceding-token ngrams: chronict?shortest-path: dobj [lemma='phosphorylation'] >prep_in [lemma='leukemia'] >rcmod [lemma='regulate'] >nsubj [lemma='induction'] >nn [lemma='erk']t_e2: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='c-myc'] Gene_or_gene_productte1: trigger: elicitst@e2: trigger-arg-path: lemmatizedTrigger=induction >nn controllertWe2: trigger-arg-path: induction:Positive_activation >prep_of [lemma='c-myc'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn Gene_or_gene_producttUe1: trigger-arg-path: elicits:Positive_regulation >nsubj [lemma='antigen'] controllertGe2: trigger-arg-path: induction:Positive_activation >prep_of controlledtje1: trigger-arg-path: elicits:Positive_regulation >nsubj [lemma='antigen'] controller:Gene_or_gene_productt9e1: trigger-arg-path: elicits >nsubj Gene_or_gene_producttZe2: trigger-arg-path: induction:Positive_activation >nn [lemma='erk'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED expression viat=e2: trigger-arg-path: Positive_activation >prep_of controlledtwe2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn [lemma='erk'] controller:Gene_or_gene_productt3e2: trigger-arg-path: induction >prep_of controlledtJe2: trigger-arg-path: lemmatizedTrigger=induction >nn Gene_or_gene_productt.e2: trigger-arg-path: induction >nn controllertie2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn controller:Gene_or_gene_producttFe2: trigger-arg-path: induction >nn [lemma='erk'] Gene_or_gene_producttCe2: trigger-arg-path: induction >prep_of [lemma='c-myc'] controlledtbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='antigen'] controller:Gene_or_gene_producttCe1: trigger-arg-path: elicits:Positive_regulation >nsubj controllert-interceding-token ngrams: chronic lymphocytict\e1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='antigen'] Gene_or_gene_productt$interceding-token ngrams: , in whichtTe2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >nn controllertEe2: trigger-arg-path: lemmatizedTrigger=induction >prep_of controlledtFe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dependent inductiont=e2: trigger-arg-path: induction >prep_of Gene_or_gene_producttQe2: trigger-arg-path: induction:Positive_activation >prep_of Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='c-myc'] controlled:Gene_or_gene_producttXe1: trigger-arg-path: elicits:Positive_regulation >nsubj controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=induction >prep_of Gene_or_gene_productt4interceding-token ngrams: B-cell chronic lymphocytict/e1: trigger-arg-path: elicits >nsubj controllertle2: trigger-arg-path: induction:Positive_activation >prep_of [lemma='c-myc'] controlled:Gene_or_gene_productt.interceding-token ngrams: lymphocytic leukemiatutrigger-to-trigger-path: e1:elicits:Positive_regulation >dobj >prep_in >rcmod >nsubj e2:induction:Positive_activationt/e1: args2Role-mention-ngram: elicits CONTROLLEDtpe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj [lemma='antigen'] Gene_or_gene_productt#interceding-token ngrams: in B-celltAe1: trigger-arg-path: elicits >nsubj [lemma='antigen'] controllert4e2: ents2Label-mention-ngram: dependent induction oftce2: trigger-arg-path: lemmatizedTrigger=induction:Positive_activation >prep_of Gene_or_gene_producttMe2: trigger-arg-path: Positive_activation >nn controller:Gene_or_gene_productt8e2: trigger-arg-path: induction >nn Gene_or_gene_productt1e2: ents2Label-mention-ngram: dependent inductiont'interceding-token ngrams: leukemia , int$interceding-token ngrams: leukemia ,tUe2: trigger-arg-path: lemmatizedTrigger=induction >prep_of [lemma='c-myc'] controlledt1e1: ents2Label-mention-ngram: stimulation elicitstKe1: trigger-arg-path: elicits >nsubj [lemma='antigen'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: induction of SHAREDt"interceding-token ngrams: in whichtprep_of controlledt]e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] theme:Familyt2e2: args2Role-mention-ngram: directly activated byte2: trigger: directly activatedtLe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] theme:Familyt^e2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllertBe1: trigger-arg-path: Binding >prep_with [lemma='ra'] theme:Familytye2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllerte2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controller:FamilytVe2: trigger-arg-path: directly activated:Positive_regulation agent >nn Familyt(e2: ents2Label-mention-ngram: binding tot?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] BindingtFe2: trigger-arg-path: directly activated agent >nn controllertke2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controlledtZe2: trigger-arg-path: directly activated:Positive_regulation agent >nn controlledt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:Familyt=e1: trigger-arg-path: interacts >prep_with [lemma='ra'] themet0e2: ents2Label-mention-ngram: directly activatedtce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3k'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='pi3k'] themetDe1: trigger-arg-path: interacts >prep_with [lemma='ra'] theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controller:Familyt/e2: args2Role-mention-ngram: directly activatedtNe1: trigger-arg-path: Binding >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn Bindingt?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controlledtte2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] Familyt*e2: ents2Label-mention-ngram: activated byt?e2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:FamilytWe2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controllertNe2: trigger-arg-path: Positive_regulation agent >nn controller:FamilytHe1: trigger-arg-path: Binding >nsubj [lemma='pi3k'] Gene_or_gene_productt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Bindingtprep_with [lemma='ra'] FamilytWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] FamilytWe2: trigger-arg-path: directly activated:Positive_regulation agent >nn BindingtMe2: trigger-arg-path: directly activated agent >nn controller:FamilytRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3k'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_with [lemma='ra'] themetOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] Familyt$interceding-tokens-full-span: and istBe2: trigger-arg-path: directly activated agent >nn Familytre2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controller:Familyt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Familytke2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controllert/e2: ents2Label-mention-ngram: SHARED binding tot?e2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingtue2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Familyt3e2: ents2Label-mention-ngram: directly activated bytve2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] BindingtZe2: trigger-arg-path: directly activated:Positive_regulation agent >nn controllert_e2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controlled:Bindingt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingtse2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controlled:BindingtGe2: trigger-arg-path: Positive_regulation agent >nn controlledtge2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn FamilytGshortest-path: advmod [lemma='directly']tie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt4e2: args2Role-mention-ngram: activated by CONTROLLERtXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt/e1: trigger-arg-path: Binding >prep_with Familyt?e2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt1e2: ents2Label-mention-ngram: activated by SHAREDt5e2: args2Role-mention-ngram: by CONTROLLER CONTROLLEDtOe2: trigger-arg-path: Positive_regulation agent >nn controlled:Bindingtxe2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controlledt1e1: trigger-arg-path: interacts >prep_with Familyt9e1: trigger-arg-path: interacts:Binding >prep_with FamilytNe2: trigger-arg-path: directly activated agent >nn controlled:Bindingt/e2: ents2Label-mention-ngram: by SHARED bindingt?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt9e1: trigger-arg-path: Binding >nsubj [lemma='pi3k'] themetJe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with Familyte2: CONTROLLED: 3tCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3k'] themet?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controllert?e1: trigger-arg-path: interacts:Binding >prep_with theme:FamilytCe2: trigger-arg-path: Positive_regulation agent >nn FamilytDe2: trigger-arg-path: Positive_regulation agent >nn Bindingt?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] FamilytEe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] themetae2: trigger-arg-path: directly activated:Positive_regulation agent >nn controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:FamilytLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3k'] themet7e1: trigger-arg-path: interacts >prep_with theme:Familyt?e2: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllert)e2: args2Role-mention-ngram: activated byt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3k'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] BindingtGe2: trigger-arg-path: Positive_regulation agent >nn controllertue2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] BindingtFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ra'] FamilytNe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] themetye2: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledtFe2: trigger-arg-path: directly activated agent >nn controlledtatrigger-to-trigger-path: e1:interacts:Binding >conj_and e2:directly activated:Positive_regulationtTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3k'] themetVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ra'] themetJe1: trigger-arg-path: interacts >nsubj [lemma='pi3k'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with theme:Familytxe2: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controllertCe2: trigger-arg-path: directly activated agent >nn Bindingthe2: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn BindingtUe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ra'] theme:FamilytBe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with Familytbe2: trigger-arg-path: directly activated:Positive_regulation agent >nn controlled:Bindingt5e1: trigger-arg-path: Binding >prep_with theme:Familyt>e1: trigger-arg-path: interacts >prep_with [lemma='ra'] Familyt=e2: ents2Label-mention-ngram: binding to GENE_OR_GENE_PRODUCTtPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with theme:FamilytSe2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn FamilytWe2: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controlledtPe1: trigger-arg-path: interacts >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttttrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='activate'] e2:directly activated:Positive_regulationt!shortest-path: advmodtme1: trigger-arg-path: Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=result >prep_by controller:Gene_or_gene_producttZe2: trigger-arg-path: results:Positive_regulation >prep_by controller:Gene_or_gene_producttBe1: trigger-arg-path: activated >agent [lemma='damage'] controllertke1: trigger-arg-path: activated:Positive_activation >agent [lemma='damage'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: by DNAthe2: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn Gene_or_gene_productt.e1: args2Role-mention-ngram: by DNA CONTROLLERt/e1: args2Role-mention-ngram: CONTROLLED pathwaytTe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn Gene_or_gene_producttme1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlledtge1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='damage'] controllert(e1: ents2Label-mention-ngram: pathway istWe1: trigger-arg-path: lemmatizedTrigger=activate >agent controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:activated:Positive_activation >agent [lemma='damage'] >rcmod [lemma='result'] e2:results:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlled:Gene_or_gene_productt!e1: ents2Label-mention-ngram: DNAt^e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn controlledt2e1: args2Role-mention-ngram: CONTROLLED pathway istKe2: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] controllertBe1: trigger-arg-path: lemmatizedTrigger=activate >agent controllert`e2: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent controllertce1: trigger-arg-path: Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlledtCe1: trigger-arg-path: Positive_activation >nsubjpass >nn controlledt3e2: ents2Label-mention-ngram: in phosphorylation oftftrigger-to-trigger-path: e1:activated:Positive_activation >agent >rcmod e2:results:Positive_regulationt3e1: args2Role-mention-ngram: generally activated bytne2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_producttWe1: trigger-arg-path: activated >agent [lemma='damage'] controller:Gene_or_gene_producttrshortest-path: agent [lemma='damage'] >rcmod [lemma='result']tZe2: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] Gene_or_gene_producttSe2: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] controllert6e1: ents2Label-mention-ngram: DNA GENE_OR_GENE_PRODUCTt~e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlledt*e1: ents2Label-mention-ngram: activated bytPe1: trigger-arg-path: Positive_activation >agent controller:Gene_or_gene_productt;e1: trigger-arg-path: Positive_activation >agent controllertVe1: trigger-arg-path: Positive_activation >agent [lemma='damage'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='damage'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: generally activated bytOe2: trigger-arg-path: results:Positive_regulation >prep_by Gene_or_gene_producttMe1: trigger-arg-path: activated:Positive_activation >nsubjpass >nn controlledtqe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='damage'] Gene_or_gene_producttUe2: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: generally activatedtYe1: trigger-arg-path: activated >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlledt'e1: args2Role-mention-ngram: pathway ist?e1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: in CONTROLLEDtJe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn controlledtLe2: trigger-arg-path: lemmatizedTrigger=result >prep_by Gene_or_gene_productt)e1: args2Role-mention-ngram: is generallyt]e2: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] controllert&e1: args2Role-mention-ngram: generallytZe1: trigger-arg-path: activated:Positive_activation >agent controller:Gene_or_gene_producttCe1: trigger-arg-path: activated >nsubjpass >nn Gene_or_gene_producttce1: trigger-arg-path: activated >nsubjpass [lemma='pathway'] >nn [lemma='p53'] Gene_or_gene_producttMe1: trigger-arg-path: Positive_activation >nsubjpass >nn Gene_or_gene_productt2e1: ents2Label-mention-ngram: pathway is generallyt|e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='damage'] controller:Gene_or_gene_productt%interceding-tokens-full-span: , whichtXe1: trigger-arg-path: Positive_activation >nsubjpass >nn controlled:Gene_or_gene_producttOe1: trigger-arg-path: activated:Positive_activation >agent Gene_or_gene_productt%e1: ents2Label-mention-ngram: pathwayt9e1: ents2Label-mention-ngram: by DNA GENE_OR_GENE_PRODUCTt$e1: args2Role-mention-ngram: pathwaytbe1: trigger-arg-path: activated:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_producttne1: trigger-arg-path: activated >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] controllertLe1: trigger-arg-path: Positive_activation >agent [lemma='damage'] controllert`e2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlledt;e1: trigger-arg-path: activated >agent Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: in CONTROLLED bytye2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: in phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=activate >agent Gene_or_gene_productt9e1: trigger-arg-path: activated >nsubjpass >nn controlledtse1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent Gene_or_gene_producttEe2: trigger-arg-path: results:Positive_regulation >prep_by controllerte1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlled:Gene_or_gene_productt0e1: args2Role-mention-ngram: generally activatedte2: trigger: resultstFe2: trigger-arg-path: results >prep_by controller:Gene_or_gene_producttxe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] controlled:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='damage'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: generallytte1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='pathway'] >nn [lemma='p53'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: activated by DNAt1e1: trigger-arg-path: activated >agent controllert e1: args2Role-mention-ngram: DNAt3e1: args2Role-mention-ngram: is generally activatedtIe2: trigger-arg-path: results >prep_by [lemma='ATM'] Gene_or_gene_productt1e2: trigger-arg-path: results >prep_by controllert`e1: trigger-arg-path: activated:Positive_activation >agent [lemma='damage'] Gene_or_gene_producttae1: trigger-arg-path: Positive_activation >agent [lemma='damage'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: is generally activatedt8e2: ents2Label-mention-ngram: results in phosphorylationtEe1: trigger-arg-path: Positive_activation >agent Gene_or_gene_productt*e1: ents2Label-mention-ngram: is generallytke2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by controller:Gene_or_gene_productt?e2: trigger-arg-path: results >prep_by [lemma='ATM'] controllertVe1: trigger-arg-path: activated:Positive_activation >agent [lemma='damage'] controllert;e2: trigger-arg-path: results >prep_by Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=result >prep_by controllertTe2: trigger-arg-path: results >prep_by [lemma='ATM'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: results in CONTROLLEDtwe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='pathway'] >nn [lemma='p53'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED pathwayt1e1: args2Role-mention-ngram: pathway is generallyt_e1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn controlled:Gene_or_gene_productt$e1: ents2Label-mention-ngram: by DNAtNe1: trigger-arg-path: activated >nsubjpass >nn controlled:Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED pathway istSe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='damage'] controllertFe1: trigger-arg-path: activated >agent controller:Gene_or_gene_producttWe1: trigger-arg-path: activated:Positive_activation >nsubjpass >nn Gene_or_gene_producttagent [lemma='damage'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] controller:Gene_or_gene_producttEe1: trigger-arg-path: activated:Positive_activation >agent controllert+e1: args2Role-mention-ngram: DNA CONTROLLERt)e1: args2Role-mention-ngram: activated byt-e1: args2Role-mention-ngram: activated by DNAtVe2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by controllert+shortest-path: agent >rcmodt*e1: ents2Label-mention-ngram: whereas T416t[e1: trigger-arg-path: association:Binding >prep_between [lemma='ezh2'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED , whereastXe1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl >nsubj >nn Sitetme1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ezh2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='association'] >prep_between [lemma='ezh2'] controller:Complext]e1: trigger-arg-path: association:Binding >prep_between [lemma='hotair'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: both T345tCe1: trigger-arg-path: association advcl >nsubj >nn site:Sitetae1: trigger-arg-path: association:Binding >prep_between [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] sitet4e2: args2Role-mention-ngram: phosphorylation inducest:e1: trigger-arg-path: Binding advcl >nsubj >nn sitet?e1: trigger-arg-path: Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] SitetPe1: trigger-arg-path: lemmatizedTrigger=association advcl >nsubj >nn Sitete1: SITE: 4t?e2: trigger-arg-path: induces dobj [lemma='association'] >prep_between [lemma='ezh2'] controller:Complext*e2: ents2Label-mention-ngram: SHARED , andt*e2: ents2Label-mention-ngram: whereas T416tNe1: trigger-arg-path: association:Binding >prep_between [lemma='hotair'] themetUe1: trigger-arg-path: association >prep_between [lemma='hotair'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: T416 phosphorylationtSe1: trigger-arg-path: association >prep_between [lemma='ezh2'] Gene_or_gene_productt[e1: trigger-arg-path: association >prep_between [lemma='hotair'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: , whereastee1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ezh2'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ezh2'] themet?e2: args2Role-mention-ngram: CONTROLLER phosphorylation inducest_e2: trigger-arg-path: induces:Positive_regulation dobj >prep_between controller:Complext>e1: trigger-arg-path: association advcl >nsubj >nn sitet7e2: args2Role-mention-ngram: CONTROLLER phosphorylationtLe2: trigger-arg-path: Positive_regulation dobj >prep_between Complext?e1: trigger-arg-path: association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] sitet(e1: args2Role-mention-ngram: and THEME ,tOe2: trigger-arg-path: Positive_regulation dobj >prep_between controllerthe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj >prep_between controllert)e2: ents2Label-mention-ngram: the bindingt,e2: ents2Label-mention-ngram: the binding oft[trigger-to-trigger-path: e1:association:Binding advcl e2:induces:Positive_regulationt.e1: ents2Label-mention-ngram: SHARED , whereast)e1: args2Role-mention-ngram: whereas SITEtWe1: trigger-arg-path: Binding >prep_between [lemma='hotair'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: inducest:e1: trigger-arg-path: Binding advcl >nsubj >nn SitetOe1: trigger-arg-path: Binding >prep_between [lemma='ezh2'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: T345t?e1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] Sitet?e1: trigger-arg-path: association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] site:SitetUe1: trigger-arg-path: lemmatizedTrigger=association advcl >nsubj >nn site:SitetKe1: trigger-arg-path: association:Binding advcl >nsubj >nn site:Sitet~trigger-to-trigger-path: e1:association:Binding advcl [lemma='induce'] e2:induces:Positive_regulationt?e1: trigger-arg-path: association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] site:Sitet?e1: trigger-arg-path: association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] Sitet)e2: ents2Label-mention-ngram: to SHARED ,t>e1: trigger-arg-path: association advcl >nsubj >nn SitetYe1: trigger-arg-path: association >prep_between [lemma='ezh2'] theme:Gene_or_gene_productt:e2: ents2Label-mention-ngram: whereas T416 phosphorylationt"e1: ents2Label-mention-ngram: T416t(e2: ents2Label-mention-ngram: , and bothtTe2: trigger-arg-path: lemmatizedTrigger=induce dobj >prep_between controllert9e2: ents2Label-mention-ngram: phosphorylation induces thet)e2: ents2Label-mention-ngram: induces thetCe2: trigger-arg-path: induces dobj >prep_between controllert'e1: ents2Label-mention-ngram: , whereast?e2: trigger-arg-path: Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] Complext+e2: ents2Label-mention-ngram: and both T345t&e2: ents2Label-mention-ngram: and botht5e2: ents2Label-mention-ngram: phosphorylation inducest?e2: trigger-arg-path: induces:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] Complextse1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] site:SitetFe1: trigger-arg-path: association:Binding advcl >nsubj >nn sitetpe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj >prep_between controller:Complext?e2: trigger-arg-path: induces:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controller:Complext@e1: trigger-arg-path: Binding >prep_between [lemma='ezh2'] themetWe2: trigger-arg-path: Positive_regulation dobj >prep_between controller:ComplextFe1: trigger-arg-path: association >prep_between [lemma='hotair'] themet?e2: trigger-arg-path: induces:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] sitet,e1: ents2Label-mention-ngram: , whereas T416t?e2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='association'] >prep_between [lemma='ezh2'] Complext?e2: trigger-arg-path: Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controller:Complext@e2: trigger-arg-path: induces dobj >prep_between Complext?e1: trigger-arg-path: association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] sitetBe1: trigger-arg-path: Binding >prep_between [lemma='hotair'] themetwe2: trigger-arg-path: induces dobj [lemma='association'] >prep_between [lemma='ezh2'] Complext$e2: args2Role-mention-ngram: inducest\e2: trigger-arg-path: lemmatizedTrigger=induce dobj >prep_between controller:Complext"e2: ents2Label-mention-ngram: T416tQe2: trigger-arg-path: lemmatizedTrigger=induce dobj >prep_between ComplextTe2: trigger-arg-path: induces:Positive_regulation dobj >prep_between Complext`e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='hotair'] themet$e1: args2Role-mention-ngram: whereast,e1: args2Role-mention-ngram: THEME , whereaste2: trigger: inducestLe1: trigger-arg-path: association:Binding >prep_between [lemma='ezh2'] themet(e2: args2Role-mention-ngram: induces thet*e1: ents2Label-mention-ngram: and SHARED ,tke1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='ezh2'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_between [lemma='hotair'] Gene_or_gene_producttDe1: trigger-arg-path: association >prep_between [lemma='ezh2'] themet?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controller:ComplextPe1: trigger-arg-path: lemmatizedTrigger=association advcl >nsubj >nn sitet?e1: trigger-arg-path: lemmatizedTrigger=association advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] Sitet+e2: args2Role-mention-ngram: the CONTROLLEDt+e1: args2Role-mention-ngram: , whereas SITEtWe2: trigger-arg-path: induces:Positive_regulation dobj >prep_between controllert,e2: args2Role-mention-ngram: phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl >nsubj >nn site:SitetFe1: trigger-arg-path: association:Binding advcl >nsubj >nn Sitet?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controllert,e2: ents2Label-mention-ngram: , whereas T416t#e2: ents2Label-mention-ngram: , andtXe1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl >nsubj >nn sitetge1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='hotair'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: induces the bindingt^e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='ezh2'] themet%e1: ents2Label-mention-ngram: whereast?e2: trigger-arg-path: Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] controllertce1: trigger-arg-path: association:Binding >prep_between [lemma='hotair'] theme:Gene_or_gene_productt8e2: args2Role-mention-ngram: phosphorylation induces thet3e2: args2Role-mention-ngram: induces the CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='association'] >prep_between [lemma='ezh2'] controllert?e1: trigger-arg-path: association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] SitetXe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='hotair'] themetze2: trigger-arg-path: induces dobj [lemma='association'] >prep_between [lemma='ezh2'] controllert:e2: ents2Label-mention-ngram: T416 phosphorylation inducestee2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj >prep_between Complext&e2: ents2Label-mention-ngram: SHARED ,t$e1: args2Role-mention-ngram: THEME ,t?e1: trigger-arg-path: Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] sitetue1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='hotair'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj [lemma='association'] >prep_between [lemma='ezh2'] Complextoe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='hotair'] Gene_or_gene_productt?e1: trigger-arg-path: Binding advcl >nsubj >nn site:Sitet?e1: trigger-arg-path: lemmatizedTrigger=association:Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] site:SitetKe2: trigger-arg-path: induces dobj >prep_between controller:Complextme1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='hotair'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding advcl [lemma='induce'] >nsubj [lemma='phosphorylation'] >nn [lemma='t416'] site:SitetUe1: trigger-arg-path: Binding >prep_between [lemma='ezh2'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: and SHARED ,the1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert?e2: trigger-arg-path: blocked nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlledte2: CONTROLLED: 5tke2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] controllertWe2: trigger-arg-path: blocked >agent [lemma='inhibition'] >nn [lemma='gsk3'] controllertNe2: trigger-arg-path: blocked nsubj >prep_of controlledt?e2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlled:Negative_regulationt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlledt*e2: ents2Label-mention-ngram: of Mcl-1 andt^e2: trigger-arg-path: lemmatizedTrigger=block nsubj >prep_of controlledt{e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] controllertDshortest-path: agent >nn controllert8e1: trigger-arg-path: induces >nsubj >prep_of controllertQe2: trigger-arg-path: blocked:Positive_regulation >agent >nn Gene_or_gene_productt!e1: args2Role-mention-ngram: S159t2e2: ents2Label-mention-ngram: S159 phosphorylationt}e1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt7e2: ents2Label-mention-ngram: subsequent ubiquitinationt\e1: trigger-arg-path: induces >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert]e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >prep_of controllertle2: trigger-arg-path: blocked >agent [lemma='inhibition'] >nn [lemma='gsk3'] controller:Gene_or_gene_productt;e2: ents2Label-mention-ngram: and subsequent ubiquitinationt)e2: ents2Label-mention-ngram: are blockedtre1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttBe1: trigger-arg-path: induces >nsubj >prep_of Gene_or_gene_producttae2: trigger-arg-path: blocked >agent [lemma='inhibition'] >nn [lemma='gsk3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlled:Negative_regulationtme1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert:e1: ents2Label-mention-ngram: induces S159 phosphorylationtMe1: trigger-arg-path: induces >nsubj >prep_of controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: Mcl-1 andt?e2: trigger-arg-path: blocked nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlled:Negative_regulationt-e2: ents2Label-mention-ngram: and degradationt?e2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] controller:Gene_or_gene_producttLe1: trigger-arg-path: induces:Negative_regulation >nsubj >prep_of controllertfe1: trigger-arg-path: induces >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_producttHe2: trigger-arg-path: blocked >agent >nn controller:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibition'] >nn [lemma='gsk3'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent >nn controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:induces:Negative_regulation >dobj [lemma='phosphorylation'] >prep_of [lemma='ubiquitination'] >rcmod [lemma='block'] e2:blocked:Positive_regulationt.e2: args2Role-mention-ngram: which are blockedt=e2: ents2Label-mention-ngram: blocked by GENE_OR_GENE_PRODUCTt/e2: args2Role-mention-ngram: CONTROLLED , whichtre2: trigger-arg-path: lemmatizedTrigger=block nsubj >prep_of controlled:Negative_regulationtae1: trigger-arg-path: induces:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: and subsequentt2e2: args2Role-mention-ngram: blocked by CONTROLLERtre1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_producttpe1: trigger-arg-path: induces:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllertltrigger-to-trigger-path: e1:induces:Negative_regulation >dobj >prep_of >rcmod e2:blocked:Positive_regulationt\e2: trigger-arg-path: blocked:Positive_regulation >agent >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlled:Negative_regulationtagent [lemma='inhibition'] >nn [lemma='gsk3'] controller:Gene_or_gene_producttbe2: trigger-arg-path: blocked:Positive_regulation nsubj >prep_of controlledt=e2: trigger-arg-path: blocked >agent >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert?e1: trigger-arg-path: induces:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: aretVe1: trigger-arg-path: induces:Negative_regulation >nsubj >prep_of Gene_or_gene_productt(e2: args2Role-mention-ngram: are blockedt2e1: ents2Label-mention-ngram: S159 phosphorylationt%e2: ents2Label-mention-ngram: blockedtIe2: trigger-arg-path: Positive_regulation >agent >nn Gene_or_gene_productt?e2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Negative_regulationtue2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlledt,e1: args2Role-mention-ngram: S159 CONTROLLEDtce2: trigger-arg-path: Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] controllert/e2: ents2Label-mention-ngram: which are blockedt1e1: ents2Label-mention-ngram: SHARED induces S159tbe2: trigger-arg-path: blocked nsubj >prep_of controlled:Negative_regulationt&e2: args2Role-mention-ngram: which aret)e2: ents2Label-mention-ngram: , which aretWe2: trigger-arg-path: blocked nsubj >prep_of Negative_regulationtze1: trigger-arg-path: induces:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: which aret?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] Gene_or_gene_producttGe2: trigger-arg-path: blocked:Positive_regulation >agent >nn controllertTe2: trigger-arg-path: Positive_regulation >agent >nn controller:Gene_or_gene_productt#e2: ents2Label-mention-ngram: Mcl-1t{e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj >prep_of Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: subsequentt4e1: args2Role-mention-ngram: induces S159 CONTROLLEDt0e2: ents2Label-mention-ngram: ubiquitination andt3e2: ents2Label-mention-ngram: degradation of SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Negative_regulationt|e2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibition'] >nn [lemma='gsk3'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: are blocked bytZe2: trigger-arg-path: Positive_regulation nsubj >prep_of controlledt,e2: ents2Label-mention-ngram: are blocked byt?e2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlledt$e2: args2Role-mention-ngram: blockedt2e2: ents2Label-mention-ngram: Mcl-1 and subsequentt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Negative_regulationt:e2: ents2Label-mention-ngram: induces S159 phosphorylationt)e2: args2Role-mention-ngram: CONTROLLED ,t4e1: args2Role-mention-ngram: CONTROLLER induces S159tXe2: trigger-arg-path: lemmatizedTrigger=block >agent >nn controller:Gene_or_gene_productte2: trigger: blockedt5e1: ents2Label-mention-ngram: S159 phosphorylation oft)e1: args2Role-mention-ngram: induces S159t?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj >prep_of controlled:Negative_regulationtke2: trigger-arg-path: blocked:Positive_regulation nsubj >prep_of Negative_regulationt)e2: ents2Label-mention-ngram: degradationtWe2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent >nn controllert?e2: trigger-arg-path: blocked nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Negative_regulationt;e2: ents2Label-mention-ngram: subsequent ubiquitination andtwe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_producttme2: trigger-arg-path: Positive_regulation >agent [lemma='inhibition'] >nn [lemma='gsk3'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED induces S159tae2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controlled:Negative_regulationt(e2: args2Role-mention-ngram: , which aret e2: args2Role-mention-ngram: aretMe2: trigger-arg-path: lemmatizedTrigger=block >agent >nn Gene_or_gene_producttve2: trigger-arg-path: blocked:Positive_regulation nsubj >prep_of controlled:Negative_regulationt&e2: ents2Label-mention-ngram: of Mcl-1tge2: trigger-arg-path: lemmatizedTrigger=block nsubj >prep_of Negative_regulationt3e2: trigger-arg-path: blocked >agent >nn controllert(e2: ents2Label-mention-ngram: blocked byt'e2: args2Role-mention-ngram: blocked byt,e2: ents2Label-mention-ngram: SHARED , whicht5e2: ents2Label-mention-ngram: S159 phosphorylation oft6e2: ents2Label-mention-ngram: phosphorylation of Mcl-1t)e2: ents2Label-mention-ngram: of SHARED ,t*e1: ents2Label-mention-ngram: induces S159tge1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >prep_of Gene_or_gene_producttshortest-path: nsubj >prep_of controlledtqe1: trigger-arg-path: induces >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_producttne2: trigger-arg-path: Positive_regulation nsubj >prep_of controlled:Negative_regulationtqe2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibition'] >nn [lemma='gsk3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Negative_regulationt,e2: ents2Label-mention-ngram: degradation oftce2: trigger-arg-path: Positive_regulation nsubj >prep_of Negative_regulationt*e2: ents2Label-mention-ngram: induces S159t$e2: args2Role-mention-ngram: or Rin1t-e1: args2Role-mention-ngram: can not interactt*e1: ents2Label-mention-ngram: not interactt`e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='a-raf'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: not interactt:e1: trigger-arg-path: interact >nsubj Gene_or_gene_productt$e2: args2Role-mention-ngram: can nott\e1: trigger-arg-path: interact:Binding >prep_with [lemma='a-raf'] theme:Gene_or_gene_producttWe2: trigger-arg-path: binds:Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_producttGtrigger-to-trigger-path: e1:interact:Binding >conj_but e2:binds:BindingtRe1: trigger-arg-path: interact >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: Rin1t(e2: args2Role-mention-ngram: , but bindstTe2: trigger-arg-path: binds:Binding >dobj [lemma='rack1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: not interact witht*e2: args2Role-mention-ngram: with A-Raf ortVe1: trigger-arg-path: interact:Binding >prep_with [lemma='a-raf'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='a-raf'] theme:Gene_or_gene_productt@e1: ents2Label-mention-ngram: interact with GENE_OR_GENE_PRODUCTt*e2: args2Role-mention-ngram: A-Raf or Rin1t.e1: args2Role-mention-ngram: not interact witht%e2: args2Role-mention-ngram: A-Raf ortKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p19-Ras'] themet:e2: trigger-arg-path: binds >nsubj [lemma='p19-Ras'] themet)e2: args2Role-mention-ngram: not interactt(e2: ents2Label-mention-ngram: with A-Raft+e2: ents2Label-mention-ngram: with A-Raf ortYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='a-raf'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rack1'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Binding >dobj [lemma='rack1'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_with [lemma='a-raf'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: A-Raf or Rin1t;shortest-path: aux [lemma='can']t'e2: args2Role-mention-ngram: with A-RaftLe1: trigger-arg-path: interact >nsubj [lemma='p19-Ras'] Gene_or_gene_producttTe1: trigger-arg-path: interact:Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >dobj [lemma='rack1'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rack1'] themet_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rack1'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: A-Raf ortFe2: trigger-arg-path: binds >dobj [lemma='rack1'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding >dobj [lemma='rack1'] themetbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED can nott(e2: ents2Label-mention-ngram: Rin1 , butt.e2: ents2Label-mention-ngram: can not interactt>e1: trigger-arg-path: Binding >prep_with [lemma='a-raf'] themet*e2: args2Role-mention-ngram: THEME can nott+e1: trigger-arg-path: interact >nsubj themet1e2: ents2Label-mention-ngram: interact with A-Raft)e1: args2Role-mention-ngram: not interactt$e2: ents2Label-mention-ngram: Rin1 ,t'e2: args2Role-mention-ngram: Rin1 , butt,e2: args2Role-mention-ngram: but binds THEMEt^e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p19-Ras'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >dobj [lemma='rack1'] theme:Gene_or_gene_producttnsubj [lemma='p19-Ras'] themet?e1: trigger-arg-path: interact >prep_with [lemma='a-raf'] themetBe2: trigger-arg-path: binds:Binding >nsubj [lemma='p19-Ras'] themetee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rack1'] theme:Gene_or_gene_productt8e2: ents2Label-mention-ngram: binds GENE_OR_GENE_PRODUCTtIe2: trigger-arg-path: binds >nsubj [lemma='p19-Ras'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='a-raf'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: Rin1 ,t'e2: ents2Label-mention-ngram: or Rin1 ,tNe1: trigger-arg-path: interact >prep_with [lemma='a-raf'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rack1'] Gene_or_gene_productt&e2: args2Role-mention-ngram: or Rin1 ,t/e1: ents2Label-mention-ngram: not interact witht'e2: ents2Label-mention-ngram: but bindst!e2: args2Role-mention-ngram: Rin1tSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p19-Ras'] themetOe2: trigger-arg-path: binds >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p19-Ras'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: can nott-e2: args2Role-mention-ngram: can not interacttEe1: trigger-arg-path: interact:Binding >nsubj [lemma='p19-Ras'] themetQe2: trigger-arg-path: Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_producttGe1: trigger-arg-path: interact:Binding >prep_with [lemma='a-raf'] themet.e1: ents2Label-mention-ngram: can not interacttTe1: trigger-arg-path: interact >prep_with [lemma='a-raf'] theme:Gene_or_gene_producttHe1: trigger-arg-path: interact:Binding >nsubj theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: A-RaftHe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rack1'] themet&e2: args2Role-mention-ngram: but bindstOe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p19-Ras'] themet%e2: ents2Label-mention-ngram: or Rin1t0e2: args2Role-mention-ngram: interact with A-RaftQe2: trigger-arg-path: binds:Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_producttBe1: trigger-arg-path: interact:Binding >nsubj Gene_or_gene_productt=e1: trigger-arg-path: interact >nsubj [lemma='p19-Ras'] themet)e2: ents2Label-mention-ngram: , but bindstZe1: trigger-arg-path: interact:Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt@e1: trigger-arg-path: interact >nsubj theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p19-Ras'] themetnsubj [lemma='p19-Ras'] themetQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='a-raf'] themetVtrigger-to-trigger-path: e1:interact:Binding >conj_but [lemma='bind'] e2:binds:Bindingt7e2: trigger-arg-path: binds >dobj [lemma='rack1'] themethe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: A-Raftnsubj [lemma='p19-Ras'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: not interact withtSe1: trigger-arg-path: Binding >prep_with [lemma='a-raf'] theme:Gene_or_gene_productt3e1: trigger-arg-path: interact:Binding >nsubj themetfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p19-Ras'] Gene_or_gene_producttLe2: trigger-arg-path: binds >dobj [lemma='rack1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: binds:Binding >dobj [lemma='rack1'] Gene_or_gene_producttshortest-path: auxthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='a-raf'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: ( Ser-1177t'e1: ents2Label-mention-ngram: Ser-473 )t-e1: ents2Label-mention-ngram: dependent Akt (te1: trigger: blockedt-e2: args2Role-mention-ngram: ) and CONTROLLEDt,e1: ents2Label-mention-ngram: blocked SHAREDt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='vegf'] Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER blockedtBe1: trigger-arg-path: blocked >nsubj >prep_of Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='vegf'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='vegf'] controller:Gene_or_gene_productt8e1: ents2Label-mention-ngram: Ser-1177 ) phosphorylationt&e2: ents2Label-mention-ngram: Ser-1177t0e1: ents2Label-mention-ngram: PI3K dependent Aktt/e2: ents2Label-mention-ngram: SHARED ( Ser-1177toe1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controllert&e1: ents2Label-mention-ngram: Ser-1177t3e2: args2Role-mention-ngram: induced PI3K dependentt e2: args2Role-mention-ngram: Aktt4e1: ents2Label-mention-ngram: induced PI3K dependentt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] Gene_or_gene_productt*e2: args2Role-mention-ngram: Akt ( Ser-473t8e1: trigger-arg-path: blocked >nsubj >prep_of controllertue1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED induced PI3Kt#e1: ents2Label-mention-ngram: Akt (tqe1: trigger-arg-path: Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: ) phosphorylationt)e2: ents2Label-mention-ngram: ( Ser-473 )te1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controllert*e1: ents2Label-mention-ngram: and SHARED (t|e1: trigger-arg-path: Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controller:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of controllert*e1: ents2Label-mention-ngram: ) and SHAREDt(e2: args2Role-mention-ngram: ( Ser-473 )t*e2: ents2Label-mention-ngram: and SHARED (t*e2: args2Role-mention-ngram: dependent Aktt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controller:Gene_or_gene_producttpe1: trigger-arg-path: blocked >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: induced PI3Kt\e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >prep_of controllert!e2: args2Role-mention-ngram: PI3Ktke1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controllert4e2: args2Role-mention-ngram: CONTROLLER induced PI3Kt*e2: ents2Label-mention-ngram: ) and SHAREDtAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT blocked SHAREDt"e2: args2Role-mention-ngram: Akt (tRe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='vegf'] controllert$e1: args2Role-mention-ngram: blockedt#e2: ents2Label-mention-ngram: Akt (t/e2: args2Role-mention-ngram: PI3K dependent Aktt&e1: ents2Label-mention-ngram: SHARED (t&e2: ents2Label-mention-ngram: SHARED (t*e1: ents2Label-mention-ngram: ( Ser-1177 )t*e2: ents2Label-mention-ngram: induced PI3KtMe1: trigger-arg-path: blocked >nsubj >prep_of controller:Gene_or_gene_producttge1: trigger-arg-path: Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controllertme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='vegf'] Gene_or_gene_productt*e2: args2Role-mention-ngram: Ser-473 ) andt)e1: ents2Label-mention-ngram: ( Ser-473 )t?e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: Aktt+e2: ents2Label-mention-ngram: dependent Aktt:e1: args2Role-mention-ngram: CONTROLLER blocked CONTROLLEDt*e2: ents2Label-mention-ngram: ( Ser-1177 )t0e2: ents2Label-mention-ngram: PI3K dependent Aktt-e2: ents2Label-mention-ngram: dependent Akt (t+e2: ents2Label-mention-ngram: Akt ( Ser-473t'e2: ents2Label-mention-ngram: ( Ser-473tce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='vegf'] controllert&e2: args2Role-mention-ngram: ( Ser-473t>e2: trigger-arg-path: induced >nsubj [lemma='vegf'] controllertOe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='vegf'] controllert"e1: ents2Label-mention-ngram: PI3Ktqe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttpshortest-path: ccomp [lemma='induce'] >nsubj [lemma='vegf']t:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT blockedtee1: trigger-arg-path: blocked >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED ( Ser-1177tae1: trigger-arg-path: blocked:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: blockedt4e2: ents2Label-mention-ngram: induced PI3K dependentt,e1: ents2Label-mention-ngram: PI3K dependentt]e1: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: Ser-473t+e2: ents2Label-mention-ngram: Ser-473 ) andtntrigger-to-trigger-path: e1:blocked:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationt8e2: ents2Label-mention-ngram: Ser-1177 ) phosphorylationt(e2: ents2Label-mention-ngram: Ser-1177 )t[e1: trigger-arg-path: blocked >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] controllert)e2: args2Role-mention-ngram: induced PI3KtTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='vegf'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: PI3K dependentt]trigger-to-trigger-path: e1:blocked:Negative_regulation >ccomp e2:induced:Positive_regulationt\e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='vegf'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: Ser-473 )t/e2: ents2Label-mention-ngram: ) phosphorylationt'e1: ents2Label-mention-ngram: dependenttde2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='vegf'] controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: Aktt"e2: ents2Label-mention-ngram: PI3Kt+e1: ents2Label-mention-ngram: dependent Aktt%e1: ents2Label-mention-ngram: Ser-473tge2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='vegf'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: ( Ser-1177t4e1: ents2Label-mention-ngram: blocked SHARED inducedtfe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >prep_of Gene_or_gene_productt"e2: args2Role-mention-ngram: ) andt,e2: args2Role-mention-ngram: dependent Akt (t+e1: ents2Label-mention-ngram: Akt ( Ser-473t'e1: ents2Label-mention-ngram: ( Ser-473tVe1: trigger-arg-path: blocked:Negative_regulation >nsubj >prep_of Gene_or_gene_productt$e2: args2Role-mention-ngram: Ser-473t#e1: ents2Label-mention-ngram: ) andtye1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='Knockdown'] >prep_of [lemma='h-ra'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: Ser-1177 )t&e2: args2Role-mention-ngram: Ser-473 )tLe1: trigger-arg-path: blocked:Negative_regulation >nsubj >prep_of controllert#e2: ents2Label-mention-ngram: ) andt1e1: ents2Label-mention-ngram: SHARED induced PI3Kt/e1: args2Role-mention-ngram: blocked CONTROLLEDt+e2: args2Role-mention-ngram: PI3K dependenttRe1: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of Gene_or_gene_producttSe2: trigger-arg-path: induced >nsubj [lemma='vegf'] controller:Gene_or_gene_producttHe2: trigger-arg-path: induced >nsubj [lemma='vegf'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='vegf'] controllert+e1: ents2Label-mention-ngram: Ser-473 ) andt0e1: ents2Label-mention-ngram: Lys382 acetylationtle1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controllertXe1: trigger-arg-path: requires >nsubj [lemma='acetylation'] >nn [lemma='p53'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] controller:Gene_or_gene_producttqe2: trigger-arg-path: phosphorylation prep_by [lemma='homeodomain'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: previoust?e1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: kinase SHAREDtne1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: Lys382 acetylation requirest6e1: ents2Label-mention-ngram: previous phosphorylationt+e1: ents2Label-mention-ngram: by the kinaset(e2: ents2Label-mention-ngram: the kinaset&e2: ents2Label-mention-ngram: at Ser46t?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: requires previoust&e1: ents2Label-mention-ngram: at Ser46t'e2: args2Role-mention-ngram: the kinasetOe1: trigger-arg-path: lemmatizedTrigger=require >nsubj >nn Gene_or_gene_producttIe1: trigger-arg-path: requires >nsubj >nn controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='homeodomain'] controllertse1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='acetylation'] >nn [lemma='p53'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: acetylation requires previoust%e1: args2Role-mention-ngram: requirest?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='homeodomain'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: of SHARED att8e1: args2Role-mention-ngram: Lys382 acetylation requirest?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='homeodomain'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: Lys382t-e1: ents2Label-mention-ngram: SHARED at Ser46t&e1: ents2Label-mention-ngram: requirestetrigger-to-trigger-path: e1:requires:Positive_regulation >dobj e2:phosphorylation:Positive_regulationt*e2: ents2Label-mention-ngram: of SHARED attashortest-path: dobj [lemma='phosphorylation']t.e1: args2Role-mention-ngram: CONTROLLER Lys382t:e1: args2Role-mention-ngram: CONTROLLER Lys382 acetylationt&e1: ents2Label-mention-ngram: Ser46 bytce1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj >nn Gene_or_gene_productt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT Lys382t&e2: ents2Label-mention-ngram: Ser46 bytue2: trigger-arg-path: Positive_regulation prep_by [lemma='homeodomain'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controllertRe1: trigger-arg-path: requires:Positive_regulation >nsubj >nn Gene_or_gene_productt/e1: ents2Label-mention-ngram: the kinase SHAREDtHe1: trigger-arg-path: requires:Positive_regulation >nsubj >nn controllertie1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='acetylation'] >nn [lemma='p53'] controllert]e1: trigger-arg-path: requires:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttge2: trigger-arg-path: phosphorylation prep_by [lemma='homeodomain'] controllert#e1: args2Role-mention-ngram: Lys382t*e1: ents2Label-mention-ngram: Ser46 by thet.e2: args2Role-mention-ngram: kinase CONTROLLERt2e1: ents2Label-mention-ngram: acetylation requirest(e1: ents2Label-mention-ngram: the kinasettrigger-to-trigger-path: e1:requires:Positive_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationte1: trigger: requirestbe1: trigger-arg-path: requires >nsubj [lemma='acetylation'] >nn [lemma='p53'] Gene_or_gene_producttve1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] Gene_or_gene_productt*e2: args2Role-mention-ngram: by the kinaset(e1: args2Role-mention-ngram: acetylationt*e2: ents2Label-mention-ngram: Ser46 by thet)e2: ents2Label-mention-ngram: at Ser46 bytxe1: trigger-arg-path: Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controller:Gene_or_gene_productt:e1: args2Role-mention-ngram: acetylation requires previoust+e2: ents2Label-mention-ngram: kinase SHAREDtce1: trigger-arg-path: Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controllert|e2: trigger-arg-path: phosphorylation prep_by [lemma='homeodomain'] controller:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=require >nsubj >nn controllert#e1: ents2Label-mention-ngram: Ser46t>e1: trigger-arg-path: requires >nsubj >nn Gene_or_gene_productt9e1: ents2Label-mention-ngram: previous phosphorylation oftEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT Lys382 acetylationt2e2: args2Role-mention-ngram: the kinase CONTROLLERt?e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: Ser46t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] controllertZe1: trigger-arg-path: lemmatizedTrigger=require >nsubj >nn controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: requires previoust0e1: args2Role-mention-ngram: previous CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] Gene_or_gene_producttke2: trigger-arg-path: Positive_regulation prep_by [lemma='homeodomain'] controllert+e2: ents2Label-mention-ngram: by the kinaset9e1: args2Role-mention-ngram: requires previous CONTROLLEDt?e2: trigger-arg-path: Positive_regulation prep_by [lemma='homeodomain'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj >nn controllertme1: trigger-arg-path: Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED at Ser46t?e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='acetylation'] >nn [lemma='p53'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: Lys382 acetylationt{e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] controllert?e1: ents2Label-mention-ngram: requires previous phosphorylationt)e1: ents2Label-mention-ngram: at Ser46 byt4e1: trigger-arg-path: requires >nsubj >nn controllert/e2: ents2Label-mention-ngram: the kinase SHAREDt~e1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='acetylation'] >nn [lemma='p53'] controller:Gene_or_gene_producttme1: trigger-arg-path: requires >nsubj [lemma='acetylation'] >nn [lemma='p53'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: acetylation requirest?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='homeodomain'] Gene_or_gene_productt%e1: args2Role-mention-ngram: previoust!interceding-token ngrams: pathwaytUe2: trigger-arg-path: Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themetDe2: trigger-arg-path: Binding >conj_or >prep_of Gene_or_gene_productt,interceding-token ngrams: guanine nucleotidetVe1: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_of [lemma='grb2-so'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_productt&interceding-token ngrams: whereas EGFRt!interceding-token ngrams: for Rast^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or >prep_of Gene_or_gene_productt]e2: trigger-arg-path: binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themet"e2: args2Role-mention-ngram: or byt!interceding-token ngrams: Ras ) ,t-interceding-token ngrams: exchange factor fort+interceding-token ngrams: pathway either bytUe2: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themet?interceding-tokens-full-span: ( SOS is a guanine nucleotide exchange factor for Ras ) , whereas EGFR activates the same pathway either by directt(e2: ents2Label-mention-ngram: by bindingt$interceding-token ngrams: nucleotidet(interceding-token ngrams: EGFR activatest,interceding-token ngrams: EGFR activates thet3e2: args2Role-mention-ngram: and phosphorylation oft'e2: ents2Label-mention-ngram: SHARED ort interceding-token ngrams: factort[e2: trigger-arg-path: binding:Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: by bindingtJe1: trigger-arg-path: complex >nn [lemma='SOS'] theme:Gene_or_gene_productt&interceding-token ngrams: is a guaninet interceding-token ngrams: directtJe1: trigger-arg-path: Binding >nn [lemma='SOS'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding advcl >prep_byt interceding-token ngrams: eithertKe1: trigger-arg-path: complex conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: or byt-e1: trigger-arg-path: complex conj_or >prep_of theme:Gene_or_gene_productt(interceding-token ngrams: factor for Rastconj_or >prep_of Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] Gene_or_gene_producttJe1: trigger-arg-path: complex:Binding prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt[shortest-path: advcl [lemma='activate'] >prep_by [lemma='binding']tLe1: trigger-arg-path: complex:Binding >nn [lemma='SOS'] Gene_or_gene_producttle2: trigger-arg-path: binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt(e2: args2Role-mention-ngram: of THEME ort"interceding-token ngrams: the sametde2: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt>e2: trigger-arg-path: binding >prep_of [lemma='grb2-so'] themet8e2: args2Role-mention-ngram: binding and phosphorylationt5e2: args2Role-mention-ngram: phosphorylation of THEMEtee2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt.interceding-token ngrams: a guanine nucleotidetre2: trigger-arg-path: binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='grb2-so'] Gene_or_gene_productt interceding-token ngrams: SOS ist'interceding-token ngrams: activates thetDe1: trigger-arg-path: complex:Binding advcl [lemma='activate'] >prep_by [lemma='binding'] e2:binding:Bindingtinterceding-token ngrams: is atKe1: trigger-arg-path: Binding conj_or >prep_of theme:Gene_or_gene_productt#interceding-token ngrams: for Ras )tRe1: trigger-arg-path: complex:Binding >nn [lemma='SOS'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >conj_or >prep_of theme:Gene_or_gene_productt)interceding-token ngrams: exchange factortYe1: trigger-arg-path: complex:Binding conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex:Binding conj_or >prep_of themetPe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] themetDe1: trigger-arg-path: complex >nn [lemma='SOS'] Gene_or_gene_productt>e2: trigger-arg-path: Binding >prep_of [lemma='grb2-so'] themetge2: trigger-arg-path: lemmatizedTrigger=binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themet*e2: args2Role-mention-ngram: or by bindingt0e2: args2Role-mention-ngram: and phosphorylationt*e2: ents2Label-mention-ngram: SHARED or byt%interceding-token ngrams: ) , whereast\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] theme:Gene_or_gene_productt"interceding-token ngrams: exchanget,e2: ents2Label-mention-ngram: by binding andt+e2: args2Role-mention-ngram: by binding andt*interceding-token ngrams: the same pathwaytDe1: trigger-arg-path: complex:Binding conj_or >prep_of theme:Gene_or_gene_producttje2: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] themet=e1: trigger-arg-path: complex:Binding >nn [lemma='SOS'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] Gene_or_gene_producttBe1: trigger-arg-path: Binding prep_of [lemma='grb2-so'] themet&interceding-token ngrams: same pathwaytSe1: trigger-arg-path: complex:Binding conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_producttinterceding-token ngrams: EGFRt-interceding-token ngrams: same pathway eithert+e2: ents2Label-mention-ngram: or by bindingtnn [lemma='SOS'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: binding andtDe2: trigger-arg-path: binding >conj_or >prep_of Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=complex advcl >prep_by e2:binding:Bindingt*interceding-token ngrams: either by directtSe2: trigger-arg-path: Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt=e2: trigger-arg-path: binding:Binding >conj_or >prep_of themetde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binding >prep_of [lemma='grb2-so'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or >prep_of themet!interceding-token ngrams: guaninet5interceding-token ngrams: guanine nucleotide exchanget%e2: args2Role-mention-ngram: THEME ort5e1: trigger-arg-path: Binding >nn [lemma='SOS'] themet-e1: trigger-arg-path: Binding conj_or [lemma='binding'] >prep_of [lemma='shc'] themetNe1: trigger-arg-path: lemmatizedTrigger=complex conj_or >prep_of themet\e1: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_of [lemma='grb2-so'] themetLe2: trigger-arg-path: binding:Binding >conj_or >prep_of Gene_or_gene_producttinterceding-token ngrams: sametJe2: trigger-arg-path: binding >conj_or >prep_of theme:Gene_or_gene_producttEe2: ents2Label-mention-ngram: phosphorylation of GENE_OR_GENE_PRODUCTtce1: trigger-arg-path: lemmatizedTrigger=complex prep_of [lemma='grb2-so'] Gene_or_gene_productt(e2: args2Role-mention-ngram: binding andt9e2: ents2Label-mention-ngram: binding and phosphorylationtVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] Gene_or_gene_productt"interceding-token ngrams: ( SOS ist-interceding-token ngrams: nucleotide exchanget#interceding-token ngrams: a guaninet(e2: args2Role-mention-ngram: THEME or bytnn [lemma='SOS'] themet~e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt$interceding-token ngrams: factor fort5e2: trigger-arg-path: binding >conj_or >prep_of themetprep_with Gene_or_gene_productt&e1: args2Role-mention-ngram: a complext&e2: args2Role-mention-ngram: a complext+e2: args2Role-mention-ngram: and then bindst+e1: args2Role-mention-ngram: a complex witht$e1: args2Role-mention-ngram: forms atJe1: trigger-arg-path: Binding nsubj theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: and then bindstPe2: trigger-arg-path: Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt4e2: trigger-arg-path: binds:Binding >prep_with themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: with HDAC1tNe1: trigger-arg-path: Binding prep_with theme:Gene_or_gene_producttRe1: trigger-arg-path: forms a complex nsubj theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: forms at?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with theme:Gene_or_gene_producttQe2: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] Gene_or_gene_productt5e1: trigger-arg-path: Binding nsubj themetJe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] Gene_or_gene_producttBe2: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] themetNe2: trigger-arg-path: binds >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: and thent-e2: ents2Label-mention-ngram: then binds withtprep_with [lemma='sp1'] themet=e2: ents2Label-mention-ngram: binds with GENE_OR_GENE_PRODUCTt+e2: args2Role-mention-ngram: with HDAC1 andte1: trigger-arg-path: Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: forms a complex:Binding prep_with themet,e2: ents2Label-mention-ngram: with HDAC1 andt'e1: ents2Label-mention-ngram: a complextEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] themetre1: trigger-arg-path: forms a complex prep_with [lemma='hdac1'] themet?e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='rbap46'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] themet)e1: args2Role-mention-ngram: complex witht%e1: ents2Label-mention-ngram: forms at/e2: args2Role-mention-ngram: complex with HDAC1t'e2: args2Role-mention-ngram: then bindstOe2: trigger-arg-path: binds >prep_with [lemma='sp1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] themetwe1: trigger-arg-path: forms a complex:Binding nsubj [lemma='rbap46'] themetPe2: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] Gene_or_gene_productt$e2: args2Role-mention-ngram: forms atZe1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with themet,e2: trigger-arg-path: binds >prep_with themetce1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: formst"e1: args2Role-mention-ngram: formst?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] theme:Gene_or_gene_productt=e1: trigger-arg-path: forms a complex nsubj themetQe2: trigger-arg-path: Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_producttze1: trigger-arg-path: forms a complex:Binding prep_with [lemma='hdac1'] themet0e2: ents2Label-mention-ngram: complex with HDAC1t&e2: args2Role-mention-ngram: HDAC1 andt?e1: ents2Label-mention-ngram: complex with GENE_OR_GENE_PRODUCTtNe1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj themet(e2: args2Role-mention-ngram: THEME formst,e1: args2Role-mention-ngram: forms a complext'e2: ents2Label-mention-ngram: HDAC1 andt-e2: ents2Label-mention-ngram: forms a complext(e2: ents2Label-mention-ngram: then bindst/e1: args2Role-mention-ngram: complex with THEMEtge1: trigger-arg-path: Binding nsubj [lemma='rbap46'] themet?e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED forms at;e2: trigger-arg-path: Binding >nsubj [lemma='rbap46'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] themetWe2: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: binds >nsubj [lemma='rbap46'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_producttEe1: trigger-arg-path: forms a complex:Binding nsubj themet,e1: ents2Label-mention-ngram: a complex witht|e1: trigger-arg-path: Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_productte2: args2Role-mention-ngram: at"e2: args2Role-mention-ngram: HDAC1t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] Gene_or_gene_productt,e2: args2Role-mention-ngram: then binds witht"e2: args2Role-mention-ngram: formstDe1: trigger-arg-path: Binding nsubj Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: forms a complextTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with Gene_or_gene_producttoe1: trigger-arg-path: forms a complex nsubj [lemma='rbap46'] themetke1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj theme:Gene_or_gene_productt;e2: trigger-arg-path: binds >prep_with Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_with Gene_or_gene_productt#e2: ents2Label-mention-ngram: HDAC1t?trigger-to-trigger-path: e1:forms a complex:Binding conj_and [lemma='bind'] e2:binds:Bindingt#e2: ents2Label-mention-ngram: formstXe1: trigger-arg-path: forms a complex:Binding prep_with Gene_or_gene_producttPe1: trigger-arg-path: forms a complex prep_with Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME formstVe1: trigger-arg-path: forms a complex prep_with theme:Gene_or_gene_producttZe1: trigger-arg-path: forms a complex:Binding nsubj theme:Gene_or_gene_producttHe2: trigger-arg-path: binds >nsubj [lemma='rbap46'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj Gene_or_gene_producttTe1: trigger-arg-path: forms a complex:Binding nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binds:Binding >prep_with theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: forms a complext?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='hdac1'] Gene_or_gene_productte2: ents2Label-mention-ngram: at*e1: args2Role-mention-ngram: THEME forms at?e1: trigger-arg-path: forms a complex prep_with [lemma='hdac1'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind >prep_with theme:Gene_or_gene_productt?e1: trigger-arg-path: forms a complex prep_with [lemma='hdac1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: complex witht~e1: trigger-arg-path: forms a complex nsubj [lemma='rbap46'] Gene_or_gene_producttLe1: trigger-arg-path: forms a complex nsubj Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='rbap46'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED formst*e2: ents2Label-mention-ngram: complex withtAe2: trigger-arg-path: binds >prep_with theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME forms atae1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_with [lemma='sp1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: a complex witht+e2: args2Role-mention-ngram: a complex witht,e2: ents2Label-mention-ngram: SHARED forms atye1: trigger-arg-path: Binding prep_with [lemma='hdac1'] Gene_or_gene_productt$shortest-path: prep_with [lemma='hdac1'] themetie1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with Gene_or_gene_producttAe1: trigger-arg-path: forms a complex prep_with themetRe1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding prep_with themetve1: trigger-arg-path: Binding nsubj [lemma='rbap46'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: binds witht:e2: trigger-arg-path: binds >prep_with [lemma='sp1'] themet=e2: trigger-arg-path: lemmatizedTrigger=bind >prep_with themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: a complextKe2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] themetIe2: trigger-arg-path: binds >prep_with [lemma='sp1'] Gene_or_gene_productte1: trigger: forms a complextge1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: binds withtCe2: trigger-arg-path: binds:Binding >prep_with Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] themet?e1: trigger-arg-path: forms a complex nsubj [lemma='rbap46'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: binds with THEMEtYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] Gene_or_gene_producttAe2: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] themet(e2: ents2Label-mention-ngram: with HDAC1t)e2: args2Role-mention-ngram: complex withtYtrigger-to-trigger-path: e1:forms a complex:Binding conj_and e2:binds:BindingtVe1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj themet,e2: ents2Label-mention-ngram: HDAC1 and thentee1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj Gene_or_gene_productt%e2: args2Role-mention-ngram: and thent+e2: args2Role-mention-ngram: HDAC1 and thentae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] Gene_or_gene_productt^e1: trigger-arg-path: forms a complex:Binding prep_with theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: IKK ) complext$e2: args2Role-mention-ngram: is thentKe2: trigger-arg-path: degraded >agent >amod controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent >nn controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: is then degradedtDe1: trigger-arg-path: phosphorylated >agent >nn Gene_or_gene_producttKe2: trigger-arg-path: Negative_regulation >agent >amod Gene_or_gene_producttJe2: trigger-arg-path: degraded:Negative_regulation >agent >amod controllert6e2: trigger-arg-path: degraded >agent >amod controllert3e2: ents2Label-mention-ngram: phosphorylated by thetTe2: trigger-arg-path: degraded:Negative_regulation >agent >amod Gene_or_gene_productt&e2: args2Role-mention-ngram: ) complext"e2: args2Role-mention-ngram: IKK )t{e2: trigger-arg-path: degraded >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controller:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=degrade >agent >amod controllert#e2: ents2Label-mention-ngram: IKK )tAe2: trigger-arg-path: Negative_regulation >agent >amod controllert:e1: trigger-arg-path: phosphorylated >agent >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controller:Gene_or_gene_producttse1: trigger-arg-path: phosphorylated >agent [lemma='complex'] >nn [lemma='ikappab'] controller:Gene_or_gene_producttqe2: trigger-arg-path: Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controllertQe2: trigger-arg-path: lemmatizedTrigger=degrade >agent >amod Gene_or_gene_productt)e2: ents2Label-mention-ngram: complex andtwe2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controllert*e2: ents2Label-mention-ngram: SHARED ( IKKtee2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent >amod Gene_or_gene_producttNe1: trigger-arg-path: phosphorylated:Positive_regulation >agent >nn controllert|e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] Gene_or_gene_productt?e2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent >nn controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='complex'] >nn [lemma='ikappab'] controllerthe1: trigger-arg-path: phosphorylated >agent [lemma='complex'] >nn [lemma='ikappab'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: then degraded byt?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: IKKtUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent >nn Gene_or_gene_producttfe2: trigger-arg-path: degraded >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controllertce1: trigger-arg-path: phosphorylated:Positive_regulation >agent >nn controller:Gene_or_gene_productt@e2: trigger-arg-path: degraded >agent >amod Gene_or_gene_productt6e2: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCTt_e2: trigger-arg-path: degraded:Negative_regulation >agent >amod controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: the SHARED (t*e2: args2Role-mention-ngram: then degradedtVe2: trigger-arg-path: Negative_regulation >agent >amod controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: and is thentme1: trigger-arg-path: Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='complex'] >nn [lemma='ikappab'] Gene_or_gene_productt(e2: args2Role-mention-ngram: complex andt[e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent >amod controllertpe2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent >amod controller:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=degrade >agent >amod controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] Gene_or_gene_productt-e2: args2Role-mention-ngram: then degraded byt*e2: args2Role-mention-ngram: ) complex andtie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent >nn Gene_or_gene_producttOe1: trigger-arg-path: phosphorylated >agent >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=degrade >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >agent >nn controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: complex and ist?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] Gene_or_gene_producttze2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controllert%e2: ents2Label-mention-ngram: ( IKK )tpe2: trigger-arg-path: degraded >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] Gene_or_gene_productt?e2: trigger-arg-path: degraded:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controller:Gene_or_gene_producttXe1: trigger-arg-path: phosphorylated:Positive_regulation >agent >nn Gene_or_gene_productt+e2: args2Role-mention-ngram: complex and ist?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controllertKe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent >nn controllert+e2: ents2Label-mention-ngram: then degradedt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='complex'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: is thentxe1: trigger-arg-path: Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controller:Gene_or_gene_producttre1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controllert*e2: args2Role-mention-ngram: IKK ) complext9e2: ents2Label-mention-ngram: by the GENE_OR_GENE_PRODUCTt^e1: trigger-arg-path: phosphorylated >agent [lemma='complex'] >nn [lemma='ikappab'] controllert(e2: args2Role-mention-ngram: and is thent?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] Gene_or_gene_productt"e2: args2Role-mention-ngram: ( IKKt-e2: args2Role-mention-ngram: CONTROLLED ( IKKt+e2: ents2Label-mention-ngram: ) complex andt$e2: args2Role-mention-ngram: ( IKK )t.e2: ents2Label-mention-ngram: is then degradedt#e2: ents2Label-mention-ngram: ( IKKt{e2: trigger-arg-path: Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] Gene_or_gene_productt e2: args2Role-mention-ngram: IKKt?e1: trigger-arg-path: Positive_regulation >agent >nn controllert?e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: ) complext)e2: args2Role-mention-ngram: CONTROLLED (tIe1: trigger-arg-path: Positive_regulation >agent >nn Gene_or_gene_productt?e2: trigger-arg-path: Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: phosphorylated by thet?e2: trigger-arg-path: lemmatizedTrigger=degrade:Negative_regulation >agent [lemma='system'] >amod [lemma='ubiquitin-proteasome'] controllertce1: trigger-arg-path: Positive_regulation >agent [lemma='complex'] >nn [lemma='ikappab'] controllertVe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >poss controlled:Generic_entitytMe2: trigger-arg-path: activates >nsubj [lemma='it'] controller:Generic_entitytdinterceding-tokens-full-span: in pancreatic cancer cells and retain Ras in the plasma membrane wheretprep_to FamilytZe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj Generic_entityt8e1: trigger-arg-path: bind:Binding >prep_to theme:Familyt5e2: trigger-arg-path: activates >nsubj Generic_entitytnsubj Generic_entitytje2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >poss controlled:Generic_entityt2e1: trigger-arg-path: bind:Binding >prep_to FamilytEe1: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] theme:Familyt interceding-token ngrams: in thet*interceding-token ngrams: cancer cells andt#interceding-token ngrams: cells andtWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] theme:Familytge2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] Generic_entitytpe2: trigger-arg-path: activates:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] Generic_entityt=e1: trigger-arg-path: bind >prep_to [lemma='ra'] theme:Familyt:e1: trigger-arg-path: Binding >prep_to [lemma='ra'] Familyt^e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] controller:Generic_entityt{e2: trigger-arg-path: activates:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlled:Generic_entitytle2: trigger-arg-path: activates:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlledt'interceding-token ngrams: in pancreatict\e2: trigger-arg-path: activates >dobj [lemma='signaling'] >poss [lemma='its'] Generic_entitytOe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] theme:FamilytFe1: trigger-arg-path: bind >nsubj [lemma='gal-3'] Gene_or_gene_producttLe1: trigger-arg-path: bind >nsubj [lemma='gal-3'] theme:Gene_or_gene_producttNe2: trigger-arg-path: activates:Positive_activation >dobj >poss Generic_entityt)e1: ents2Label-mention-ngram: can bind totRe2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] controllertJe2: trigger-arg-path: Positive_activation >nsubj controller:Generic_entityt1interceding-token ngrams: pancreatic cancer cellstLe2: trigger-arg-path: Positive_activation >nsubj [lemma='it'] Generic_entitytre2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] controller:Generic_entitytKe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >poss Generic_entityt*e1: args2Role-mention-ngram: bind to THEMEtfe2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] Generic_entityt?e2: trigger-arg-path: Positive_activation >nsubj Generic_entityt*e1: trigger-arg-path: bind >prep_to Familyt&interceding-token ngrams: cancer cellst'interceding-token ngrams: in the plasmatqe2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlled:Generic_entityt)e1: trigger-arg-path: bind >prep_to themet?e1: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >poss Generic_entityt-e1: ents2Label-mention-ngram: SHARED can bindt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt>e1: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] themet$interceding-token ngrams: Ras in thet$e1: args2Role-mention-ngram: bind totYe2: trigger-arg-path: activates:Positive_activation >dobj >poss controlled:Generic_entityt interceding-token ngrams: cancert[e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >poss controlledt/interceding-token ngrams: plasma membrane wheret3e1: trigger-arg-path: Binding >prep_to theme:Familyt}e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlledtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt+interceding-token ngrams: pancreatic cancertme2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='signaling'] >poss [lemma='its'] Generic_entityt interceding-token ngrams: Ras intHe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] themetXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] controllertOe2: trigger-arg-path: Positive_activation >dobj >poss controlled:Generic_entityt1e2: args2Role-mention-ngram: CONTROLLER activatestae2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] controller:Generic_entitytJe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:FamilytDe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to FamilytXe2: trigger-arg-path: activates >dobj [lemma='signaling'] >poss [lemma='its'] controlledt:e1: trigger-arg-path: Binding >nsubj [lemma='gal-3'] themet(interceding-token ngrams: and retain Rast7e1: trigger-arg-path: bind >prep_to [lemma='ra'] FamilytQe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Generic_entityt6e1: trigger-arg-path: bind >prep_to [lemma='ra'] themet(e1: args2Role-mention-ngram: can bind tot$interceding-token ngrams: the plasmatEe2: trigger-arg-path: activates:Positive_activation >nsubj controllert`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] Gene_or_gene_productt1e2: args2Role-mention-ngram: activates CONTROLLEDtSe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] Generic_entityt9e1: trigger-arg-path: Binding >prep_to [lemma='ra'] themet$interceding-token ngrams: pancreatictEe2: trigger-arg-path: activates >dobj >poss controlled:Generic_entityt%e1: ents2Label-mention-ngram: bind tot,e1: ents2Label-mention-ngram: bind to SHAREDt1e2: trigger-arg-path: activates >nsubj controllert)interceding-token ngrams: plasma membranetZtrigger-to-trigger-path: e1:bind:Binding >conj_and >advcl e2:activates:Positive_activationt$interceding-token ngrams: and retaint.e2: ents2Label-mention-ngram: SHARED activatest?e1: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] themetTe2: trigger-arg-path: activates:Positive_activation >nsubj controller:Generic_entitytIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] FamilytOe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] controllertQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] Familyt$interceding-token ngrams: retain RastVe2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] Generic_entityt interceding-token ngrams: plasmatBe2: trigger-arg-path: activates >nsubj [lemma='it'] Generic_entitytIe1: trigger-arg-path: Binding >nsubj [lemma='gal-3'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >poss controlledt>e2: trigger-arg-path: activates >nsubj [lemma='it'] controllert:e2: trigger-arg-path: activates >dobj >poss Generic_entityt-e1: trigger-arg-path: Binding >prep_to Familyt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] Generic_entityt-interceding-token ngrams: the plasma membranetTshortest-path: advcl [lemma='activate'] >nsubj [lemma='it']t7e1: trigger-arg-path: bind >nsubj [lemma='gal-3'] themet*interceding-token ngrams: cells and retainte2: trigger: activatestHe2: trigger-arg-path: Positive_activation >nsubj [lemma='it'] controllertPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] themetTe1: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt6e2: trigger-arg-path: activates >dobj >poss controlledt5e2: ents2Label-mention-ngram: SHARED activates SHAREDt interceding-token ngrams: retaint@e1: trigger-arg-path: Binding >prep_to [lemma='ra'] theme:Familyt0e1: trigger-arg-path: bind >prep_to theme:Familyt(interceding-token ngrams: membrane wheret?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlled:Generic_entitytOe1: trigger-arg-path: Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt.interceding-token ngrams: in pancreatic cancert@e2: trigger-arg-path: Positive_activation >dobj >poss controlledtxe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='signaling'] >poss [lemma='its'] controlled:Generic_entitytNe1: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='signaling'] >poss [lemma='its'] controlledtFe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj Generic_entityt.e2: ents2Label-mention-ngram: activates SHAREDtJe2: trigger-arg-path: activates:Positive_activation >dobj >poss controlledt&e2: args2Role-mention-ngram: activatest~trigger-to-trigger-path: e1:bind:Binding >conj_and [lemma='retain'] >advcl [lemma='activate'] e2:activates:Positive_activationt'interceding-token ngrams: retain Ras intge2: trigger-arg-path: activates >dobj [lemma='signaling'] >poss [lemma='its'] controlled:Generic_entityt1e1: trigger-arg-path: bind:Binding >prep_to themetWe2: trigger-arg-path: Positive_activation >nsubj [lemma='it'] controller:Generic_entityt@e2: trigger-arg-path: activates >nsubj controller:Generic_entitytDe2: trigger-arg-path: Positive_activation >dobj >poss Generic_entitytIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] themetie2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='signaling'] >poss [lemma='its'] controlledtBe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to theme:FamilytQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] themetee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:Generic_entityt&e1: ents2Label-mention-ngram: ( at Y55t?trigger-to-trigger-path: e1:induces:Positive_regulation >dobj [lemma='phosphorylation'] >prep_of [lemma='spry2'] >dep [lemma='enhance'] >prep_to [lemma='domain'] >prep_of [lemma='c-cbl'] >rcmod [lemma='lead'] e2:leads:Positive_regulationtee2: trigger-arg-path: Positive_regulation >prep_to [lemma='ubiquitination'] controlled:UbiquitinationtAe2: trigger-arg-path: Positive_regulation >prep_to Ubiquitinationtme2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >prep_to [lemma='ubiquitination'] controlledt&e1: args2Role-mention-ngram: ) inducest0e2: args2Role-mention-ngram: leads to CONTROLLEDt$interceding-token ngrams: SH2 domaint$interceding-token ngrams: to the SH2tle2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation prep_to controlled:Ubiquitinationt.e1: ents2Label-mention-ngram: induces tyrosinet'interceding-token ngrams: SH2 domain oft]e2: trigger-arg-path: lemmatizedTrigger=lead >prep_to [lemma='ubiquitination'] Ubiquitinationt>e2: trigger-arg-path: lemmatizedTrigger=lead nsubj [lemma='stimulation'] >appos [lemma='egfr'] Gene_or_gene_productt>e2: trigger-arg-path: leads >prep_to controlled:Ubiquitinationt)e1: args2Role-mention-ngram: CONTROLLER )tWe1: trigger-arg-path: Positive_regulation >nsubj >appos controller:Gene_or_gene_productt\e2: trigger-arg-path: leads:Positive_regulation >prep_to [lemma='ubiquitination'] controlledtinterceding-token ngrams: SH2tTe1: trigger-arg-path: induces:Positive_regulation >nsubj >appos Gene_or_gene_productt!interceding-token ngrams: residuetbe2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation prep_to [lemma='ubiquitination'] controlled:UbiquitinationtRe2: trigger-arg-path: leads:Positive_regulation >prep_to controlled:Ubiquitinationt#e2: ents2Label-mention-ngram: leadst(interceding-token ngrams: the SH2 domaint[e1: trigger-arg-path: induces >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controllertYe2: trigger-arg-path: lemmatizedTrigger=lead >prep_to [lemma='ubiquitination'] controlledt`e2: trigger-arg-path: leads:Positive_regulation >prep_to [lemma='ubiquitination'] UbiquitinationtVe2: trigger-arg-path: Positive_regulation >prep_to [lemma='ubiquitination'] controlledthe2: trigger-arg-path: lemmatizedTrigger=lead >prep_to [lemma='ubiquitination'] controlled:Ubiquitinationt interceding-token ngrams: domaint=e2: trigger-arg-path: leads prep_to [lemma='ubiquitination'] Ubiquitinationt@e1: trigger-arg-path: induces >nsubj >appos Gene_or_gene_productt7e2: trigger-arg-path: leads nsubj >appos controllert%interceding-token ngrams: its bindingt!e1: ents2Label-mention-ngram: Y55t/e2: trigger-arg-path: leads >prep_to controlledt.interceding-token ngrams: its binding affinityt1e1: args2Role-mention-ngram: CONTROLLER ) inducest'interceding-token ngrams: enhancing itstNe2: trigger-arg-path: lemmatizedTrigger=lead dobj >prep_of >dep >prep_to >prep_oft"e1: ents2Label-mention-ngram: ( attOe2: trigger-arg-path: lemmatizedTrigger=lead >prep_to controlled:UbiquitinationtQe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >appos Gene_or_gene_producttye1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='stimulation'] >appos [lemma='egfr'] Gene_or_gene_productt[e2: trigger-arg-path: leads:Positive_regulation prep_to controlledtge1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controllert-e1: args2Role-mention-ngram: induces tyrosinet|e2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >prep_to [lemma='ubiquitination'] controlled:Ubiquitinationtpe1: trigger-arg-path: induces >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: tyrosine phosphorylation oft\e2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nsubj [lemma='stimulation'] >appos [lemma='egfr'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: leads to SHAREDt)e1: ents2Label-mention-ngram: of SHARED (t6e1: trigger-arg-path: induces >nsubj >appos controllert#interceding-token ngrams: enhancingtLe2: trigger-arg-path: Positive_regulation >prep_to controlled:Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: which leads tot)e1: ents2Label-mention-ngram: SHARED ( attwe2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nsubj [lemma='stimulation'] >appos [lemma='egfr'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >appos [lemma='egfr'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: ) induces tyrosinetge2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nsubj [lemma='stimulation'] >appos [lemma='egfr'] controllert`e2: trigger-arg-path: Positive_regulation prep_to Ubiquitinationt-interceding-token ngrams: binding affinity totCe2: trigger-arg-path: leads:Positive_regulation >prep_to controlledtKe2: trigger-arg-path: leads:Positive_regulation nsubj >appos controllerte2: trigger: leadst0e1: args2Role-mention-ngram: tyrosine CONTROLLEDtGe2: trigger-arg-path: leads nsubj [lemma='stimulation'] >appos [lemma='egfr'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: , which leadst-interceding-token ngrams: residue ) enhancingtGe2: trigger-arg-path: leads:Positive_regulation >prep_to Ubiquitinationte1: args2Role-mention-ngram: )tle1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >appos [lemma='egfr'] controllert%interceding-token ngrams: affinity totJe1: trigger-arg-path: induces:Positive_regulation >nsubj >appos controllert)e2: ents2Label-mention-ngram: which leadstee1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >appos Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >prep_to Ubiquitinationt%e1: args2Role-mention-ngram: tyrosinetBe2: trigger-arg-path: leads dobj [lemma='phosphorylation'] >prep_of [lemma='spry2'] >dep [lemma='enhance'] >prep_to [lemma='domain'] >prep_of [lemma='c-cbl']t?trigger-to-trigger-path: e1:induces:Positive_regulation >dobj >prep_of >dep >prep_to >prep_of >rcmod e2:leads:Positive_regulationt&e2: ents2Label-mention-ngram: leads tot(e2: args2Role-mention-ngram: which leadstqe2: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >prep_to [lemma='ubiquitination'] Ubiquitinationt_e1: trigger-arg-path: induces:Positive_regulation >nsubj >appos controller:Gene_or_gene_productt-e2: trigger-arg-path: leads e1: ents2Label-mention-ngram: induces tyrosine phosphorylationtAe2: trigger-arg-path: leads:Positive_regulation nsubj >appos Gene_or_gene_producttfe2: trigger-arg-path: leads:Positive_regulation prep_to Ubiquitinationt[interceding-tokens-full-span: residue ) enhancing its binding affinity to the SH2 domain oft)interceding-token ngrams: ) enhancing itstUe2: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >appos [lemma='egfr'] controllert[e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >appos controllertee1: trigger-arg-path: induces >nsubj [lemma='stimulation'] >appos [lemma='egfr'] Gene_or_gene_producttHe2: trigger-arg-path: leads >prep_to [lemma='ubiquitination'] controlledt\e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >appos controller:Gene_or_gene_productt*interceding-token ngrams: binding affinitytRe2: trigger-arg-path: leads nsubj >appos controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=lead >prep_to controlledt#interceding-token ngrams: residue )tke2: trigger-arg-path: leads:Positive_regulation >prep_to [lemma='ubiquitination'] controlled:UbiquitinationtQe2: trigger-arg-path: leads:Positive_regulation nsubj >appos controller:Gene_or_gene_producttZe2: trigger-arg-path: Positive_regulation >prep_to [lemma='ubiquitination'] Ubiquitinationt1e2: args2Role-mention-ngram: regulatory effect oftWe1: trigger-arg-path: phosphorylation >nn [lemma='akt'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: negativet(e2: ents2Label-mention-ngram: abolishingt+interceding-token ngrams: TSC2 and disruptst?trigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_with [lemma='tsc1'] >vmod [lemma='abolish'] e2:abolishing:Negative_regulationtie2: trigger-arg-path: abolishing:Negative_regulation nn controllertBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylationt$e2: ents2Label-mention-ngram: effectt'e2: args2Role-mention-ngram: abolishingtOe2: trigger-arg-path: lemmatizedTrigger=abolish nn [lemma='akt'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=abolish:Negative_regulation nn [lemma='akt'] controllert8e2: ents2Label-mention-ngram: negative regulatory effectt*interceding-token ngrams: interaction witht.e2: args2Role-mention-ngram: regulatory effecttVe1: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] controllert!e2: args2Role-mention-ngram: thust/interceding-token ngrams: destabilizes TSC2 andtBe1: trigger-arg-path: Positive_regulation >nn Gene_or_gene_productt$shortest-path: prep_witht4e2: args2Role-mention-ngram: the negative regulatorytIe2: trigger-arg-path: Negative_regulation nn controllertIe1: trigger-arg-path: phosphorylation >nn controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: abolishing the negativet*e2: ents2Label-mention-ngram: the negativetytrigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_with >vmod e2:abolishing:Negative_regulationt7e2: args2Role-mention-ngram: negative regulatory effecttJe2: trigger-arg-path: abolishing nn Gene_or_gene_producttke1: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] controller:Gene_or_gene_producttOe2: trigger-arg-path: abolishing:Negative_regulation nn [lemma='akt'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn Gene_or_gene_productt)interceding-token ngrams: its interactiont#e2: args2Role-mention-ngram: effectt/e2: ents2Label-mention-ngram: regulatory effecttTe2: trigger-arg-path: abolishing:Negative_regulation nn controller:Gene_or_gene_productt^e2: trigger-arg-path: Negative_regulation nn controllertxe2: trigger-arg-path: lemmatizedTrigger=abolish:Negative_regulation nn controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn controllert.e2: ents2Label-mention-ngram: effect of SHAREDt)e2: args2Role-mention-ngram: the negativet_shortest-path: prep_with [lemma='tsc1']tde2: trigger-arg-path: lemmatizedTrigger=abolish e1: trigger-arg-path: phosphorylation >nn Gene_or_gene_productt"interceding-token ngrams: disruptst1e2: ents2Label-mention-ngram: thus abolishing thetYe2: trigger-arg-path: lemmatizedTrigger=abolish nn [lemma='akt'] controller:Gene_or_gene_producttLe1: trigger-arg-path: phosphorylation >nn [lemma='akt'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: the negative regulatoryt5e2: ents2Label-mention-ngram: abolishing the negativet4e1: trigger-arg-path: phosphorylation >nn controllert;e2: trigger-arg-path: abolishing nn Gene_or_gene_productt:e2: trigger-arg-path: Negative_regulation nn controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: , thust&interceding-token ngrams: disrupts itst'e2: args2Role-mention-ngram: regulatorytFe1: trigger-arg-path: Positive_regulation >nn [lemma='akt'] controllert[e1: trigger-arg-path: Positive_regulation >nn [lemma='akt'] controller:Gene_or_gene_producttSe2: trigger-arg-path: Negative_regulation nn [lemma='akt'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , thust%e2: args2Role-mention-ngram: negativetme2: trigger-arg-path: lemmatizedTrigger=abolish:Negative_regulation nn [lemma='akt'] controllertUe2: trigger-arg-path: abolishing nn [lemma='akt'] controllert0e2: args2Role-mention-ngram: thus abolishing thetie2: trigger-arg-path: lemmatizedTrigger=abolish:Negative_regulation nn [lemma='akt'] controller:Gene_or_gene_productt`e1: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] Gene_or_gene_productt5e2: trigger-arg-path: binds >nsubj [lemma='ra'] themet>e2: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] Familytee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] FamilytZe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:FamilytKe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] themetOe2: trigger-arg-path: Binding >prep_to [lemma='raf'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='ra'] Familyt+e2: trigger-arg-path: Binding >nsubj FamilytGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] FamilytUe2: trigger-arg-path: binds:Binding >prep_to [lemma='raf'] theme:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Familyt^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf'] theme:Gene_or_gene_productt>e1: trigger-arg-path: bound:Binding >ccomp >nsubj theme:FamilytOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ra'] Familytfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ra'] themetIe2: trigger-arg-path: Binding >prep_to [lemma='raf'] Gene_or_gene_productt=e2: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] themetLe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt1e2: trigger-arg-path: binds:Binding >nsubj FamilytIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf'] themet)e2: trigger-arg-path: binds >nsubj Familyt:e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj Familyt8e1: trigger-arg-path: bound:Binding >ccomp >nsubj Familyt8e1: trigger-arg-path: Binding >ccomp >nsubj theme:FamilytFe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] themet8e2: trigger-arg-path: binds >prep_to [lemma='raf'] themetNe1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt6e2: trigger-arg-path: binds >nsubj [lemma='ra'] Familyt6e1: trigger-arg-path: bound >ccomp >nsubj theme:FamilytHe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:FamilytXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf'] Gene_or_gene_productt1e2: trigger-arg-path: Binding >nsubj theme:FamilytGe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj theme:Familyt@e2: trigger-arg-path: binds:Binding >prep_to [lemma='raf'] themet\e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet7e2: trigger-arg-path: binds:Binding >nsubj theme:FamilytTe1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familyt0e1: trigger-arg-path: bound >ccomp >nsubj FamilytAe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj Familytke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familyt>e2: trigger-arg-path: Binding >nsubj [lemma='ra'] theme:FamilytOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj theme:FamilytRe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:FamilytMe1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet7e2: trigger-arg-path: Binding >nsubj [lemma='ra'] themetOe2: trigger-arg-path: binds:Binding >prep_to [lemma='raf'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf'] themet2e1: trigger-arg-path: Binding >ccomp >nsubj FamilytMe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] theme:FamilytTe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt/e2: trigger-arg-path: binds >nsubj theme:FamilytMe2: trigger-arg-path: binds >prep_to [lemma='raf'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familytnsubj [lemma='ra'] theme:Familyt:e2: trigger-arg-path: Binding >prep_to [lemma='raf'] themetGe2: trigger-arg-path: binds >prep_to [lemma='raf'] Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themetUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ra'] theme:Familyt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf'] Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj FamilytIe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj Familyt]e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] FamilytNshortest-path: ccomp [lemma='bind'] >nsubj [lemma='ra']tDe2: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] theme:Familyt_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] themetPe2: trigger-arg-path: interacts >nsubj [lemma='mycn'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='mycn'] themetPe1: trigger-arg-path: interacts >nsubj [lemma='mycn'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] themetJe2: trigger-arg-path: interacts >nsubj [lemma='mycn'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] themetme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts >prep_with [lemma='ezh2'] themetRe1: trigger-arg-path: Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttRe2: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='mycn'] Gene_or_gene_producttHe2: trigger-arg-path: Binding >nsubj [lemma='mycn'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='ezh2'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] Gene_or_gene_producttEe2: trigger-arg-path: interacts >prep_with theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] themetCe2: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] themetVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_productt;e2: trigger-arg-path: interacts >nsubj [lemma='mycn'] themet9e2: trigger-arg-path: Binding >nsubj [lemma='mycn'] themetXe2: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: interacts >prep_with Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='mycn'] Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_with [lemma='ezh2'] themetLe1: trigger-arg-path: Binding >prep_with [lemma='ezh2'] Gene_or_gene_producttMe2: trigger-arg-path: interacts:Binding >prep_with theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='ezh2'] themetce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mycn'] Gene_or_gene_producttNe1: trigger-arg-path: interacts >prep_with [lemma='ezh2'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='mycn'] themet?e2: trigger-arg-path: interacts >prep_with [lemma='ezh2'] themetce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] themetGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] themetPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] themetge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] Gene_or_gene_productt\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_productt\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mycn'] theme:Gene_or_gene_producttNe2: trigger-arg-path: interacts >prep_with [lemma='ezh2'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] Gene_or_gene_producttGe2: trigger-arg-path: interacts:Binding >prep_with Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttGe2: trigger-arg-path: interacts:Binding >prep_with [lemma='ezh2'] themetTe1: trigger-arg-path: interacts >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] themetee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ezh2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ezh2'] themetLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mycn'] themetTe2: trigger-arg-path: interacts >prep_with [lemma='ezh2'] theme:Gene_or_gene_productt`e1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlledt.interceding-token ngrams: requires their firstt,interceding-token ngrams: to coactivate witht&e1: ents2Label-mention-ngram: ASPP2 tot0e2: args2Role-mention-ngram: THEME interact witht#interceding-token ngrams: apoptosist$interceding-token ngrams: coactivatetinterceding-token ngrams: aretue1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlled:Gene_or_gene_producttHe1: trigger-arg-path: stimulate:Positive_activation >dobj >nn controlledtZe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn controlledt\e1: trigger-arg-path: stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controllertRe1: trigger-arg-path: stimulate:Positive_activation >dobj >nn Gene_or_gene_productt4e1: args2Role-mention-ngram: to stimulate CONTROLLEDtinterceding-token ngrams: acidstje1: trigger-arg-path: Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn controlled:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='they'] themet|e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controllertce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='they'] theme:Generic_entityt$interceding-token ngrams: as mutantstSe1: trigger-arg-path: Positive_activation >dobj >nn controlled:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >prep_of controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of controllert$interceding-token ngrams: are unablet.interceding-token ngrams: unable to coactivatetqe1: trigger-arg-path: stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controller:Gene_or_gene_producttfe1: trigger-arg-path: Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controllert!interceding-token ngrams: lackingt(interceding-token ngrams: requires theirt0interceding-token ngrams: dependent apoptosis int&e1: args2Role-mention-ngram: stimulatetinterceding-token ngrams: themt?shortest-path: advcl [lemma='interact'] >nsubj [lemma='they']t:e2: trigger-arg-path: interact >nsubj [lemma='they'] themetQe2: trigger-arg-path: interact:Binding >nsubj [lemma='they'] theme:Generic_entityt)e1: args2Role-mention-ngram: to stimulatetLe2: trigger-arg-path: interact >prep_with [lemma='p53'] Gene_or_gene_productt!interceding-token ngrams: mutantstKe2: trigger-arg-path: interact:Binding >nsubj [lemma='they'] Generic_entityt#interceding-token ngrams: unable totNe1: trigger-arg-path: Positive_activation >nsubj >prep_of Gene_or_gene_producttXe1: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn Gene_or_gene_producttRe2: trigger-arg-path: interact >prep_with [lemma='p53'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controller:Gene_or_gene_producttZe2: trigger-arg-path: interact:Binding >prep_with [lemma='p53'] theme:Gene_or_gene_productt-interceding-token ngrams: dependent apoptosist$interceding-token ngrams: p53 , event"interceding-token ngrams: with p53t-e2: ents2Label-mention-ngram: SHARED interactt'e1: ents2Label-mention-ngram: stimulatetHe1: trigger-arg-path: Positive_activation >dobj >nn Gene_or_gene_productt?interceding-tokens-full-span: dependent apoptosis in cancer cells also requires their first 120 amino acids , as mutants lacking them are unable to coactivate with p53 , even thought-interceding-token ngrams: apoptosis in cancertpe1: trigger-arg-path: Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] Gene_or_gene_productt.interceding-token ngrams: mutants lacking themt&e1: args2Role-mention-ngram: and ASPP2tinterceding-token ngrams: 120tYe1: trigger-arg-path: Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt)interceding-token ngrams: 120 amino acidst>e1: trigger-arg-path: Positive_activation >dobj >nn controlledtinterceding-token ngrams: p53 ,tTe2: trigger-arg-path: interact:Binding >prep_with [lemma='p53'] Gene_or_gene_productt]e1: trigger-arg-path: stimulate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt'interceding-token ngrams: are unable totxe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='they'] themetke1: trigger-arg-path: stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlled:Gene_or_gene_productt,interceding-token ngrams: as mutants lackingt)interceding-token ngrams: first 120 aminotde1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn Gene_or_gene_producttBe2: trigger-arg-path: interact:Binding >nsubj [lemma='they'] themet)interceding-token ngrams: in cancer cellst interceding-token ngrams: thought*interceding-token ngrams: lacking them aret.e1: ents2Label-mention-ngram: stimulate SHAREDt)e1: args2Role-mention-ngram: and ASPP2 tot{e1: trigger-arg-path: Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controller:Gene_or_gene_producttje1: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='p53'] Gene_or_gene_productt=e2: trigger-arg-path: interact >prep_with [lemma='p53'] themetinterceding-token ngrams: firstt%interceding-token ngrams: amino acidst*e1: ents2Label-mention-ngram: to stimulatetOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='p53'] themet#interceding-token ngrams: first 120tVe1: trigger-arg-path: stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlledthe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlledtDe1: trigger-arg-path: Positive_activation >nsubj >prep_of controllert+e2: args2Role-mention-ngram: THEME interactt'e1: ents2Label-mention-ngram: and ASPP2t2e2: ents2Label-mention-ngram: interact with SHAREDt-interceding-token ngrams: also requires theirtFe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn controlledtIe1: trigger-arg-path: stimulate >dobj >nn controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED and ASPP2t?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlled:Gene_or_gene_productt#interceding-token ngrams: in cancert/e1: args2Role-mention-ngram: ASPP2 to stimulatet?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] Gene_or_gene_productte1: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='they'] theme:Generic_entitytUe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='they'] Generic_entityt&interceding-token ngrams: apoptosis intNe1: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of controllert&interceding-token ngrams: lacking themt interceding-token ngrams: , event'interceding-token ngrams: amino acids ,tQe2: trigger-arg-path: Binding >prep_with [lemma='p53'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interact >nsubj [lemma='they'] Generic_entitytze1: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_with [lemma='p53'] Gene_or_gene_producttBe2: trigger-arg-path: Binding >nsubj [lemma='they'] Generic_entityt1e1: args2Role-mention-ngram: CONTROLLER and ASPP2tVe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] Gene_or_gene_productt)interceding-token ngrams: them are unablet%interceding-token ngrams: even thought-interceding-token ngrams: cells also requirestue1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of controller:Gene_or_gene_producttinterceding-token ngrams: aminot*e1: ents2Label-mention-ngram: and ASPP2 totpe1: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controllert&interceding-token ngrams: , as mutantst?e1: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controller:Gene_or_gene_productt[trigger-to-trigger-path: e1:stimulate:Positive_activation advcl e2:interact:Bindingt0e1: ents2Label-mention-ngram: ASPP2 to stimulatet)interceding-token ngrams: coactivate witht1e1: ents2Label-mention-ngram: to stimulate SHAREDtHe2: trigger-arg-path: Binding >nsubj [lemma='they'] theme:Generic_entityt"e1: args2Role-mention-ngram: ASPP2t1e1: args2Role-mention-ngram: stimulate CONTROLLEDtEe2: trigger-arg-path: interact:Binding >prep_with [lemma='p53'] themet#e1: ents2Label-mention-ngram: ASPP2tWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='p53'] themet!interceding-token ngrams: acids ,tIe2: trigger-arg-path: interact >nsubj [lemma='they'] theme:Generic_entitytfe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='p53'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='they'] Generic_entitytne1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controllert:e1: trigger-arg-path: stimulate >nsubj >prep_of controllert-interceding-token ngrams: coactivate with p53t3shortest-path: advcl >nsubjt+interceding-token ngrams: cancer cells alsotce1: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt'interceding-token ngrams: also requirest>e1: trigger-arg-path: stimulate >dobj >nn Gene_or_gene_producttte1: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='apoptosis'] >nn [lemma='p53'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: SHARED interact withtfe1: trigger-arg-path: stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] Gene_or_gene_productt interceding-token ngrams: unablet)interceding-token ngrams: their first 120tLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='they'] themet$interceding-token ngrams: with p53 ,tje1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of Gene_or_gene_producttinterceding-token ngrams: eventde2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='p53'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:stimulate:Positive_activation advcl [lemma='interact'] e2:interact:Bindingtre1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn controlled:Gene_or_gene_productt"interceding-token ngrams: them aret$interceding-token ngrams: cells alsotOe1: trigger-arg-path: stimulate >nsubj >prep_of controller:Gene_or_gene_productt`e1: trigger-arg-path: stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] Gene_or_gene_producttinterceding-token ngrams: p53t%interceding-token ngrams: their firstt$interceding-token ngrams: acids , ast4e1: trigger-arg-path: stimulate >dobj >nn controlledte1: trigger: stimulatetle2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='p53'] theme:Gene_or_gene_productt#interceding-token ngrams: 120 aminot'interceding-token ngrams: , even thought}e1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='apoptosis'] >nn [lemma='p53'] controlled:Gene_or_gene_productt'interceding-token ngrams: to coactivatetprep_with [lemma='p53'] themetLe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='ability'] >prep_of [lemma='aspp1'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: ASPP2 totDe1: trigger-arg-path: stimulate >nsubj >prep_of Gene_or_gene_productt)interceding-token ngrams: mutants lackingt#e2: ents2Label-mention-ngram: dimert#e2: args2Role-mention-ngram: or twotqe1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controllert*e2: ents2Label-mention-ngram: ubiquitinatetTe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn Gene_or_gene_productt.e2: args2Role-mention-ngram: containing one ort+e2: args2Role-mention-ngram: containing onet,e2: ents2Label-mention-ngram: containing onet2e2: args2Role-mention-ngram: mutant Keap1 proteinste1: trigger: ubiquitinatest5e2: ents2Label-mention-ngram: not ubiquitinate SHAREDtce1: trigger-arg-path: Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controllertLe2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj >nn controllert+e1: ents2Label-mention-ngram: ubiquitinatest1e1: args2Role-mention-ngram: homodimer CONTROLLEDt e2: args2Role-mention-ngram: twotre1: trigger-arg-path: ubiquitinates >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: proteins ,tje2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='dimer'] >nn [lemma='keap1'] controllertge1: trigger-arg-path: ubiquitinates >nsubj [lemma='homodimer'] >nn [lemma='keap1'] Gene_or_gene_producttinterceding-token ngrams: whilet'e2: args2Role-mention-ngram: proteins ,tNe1: trigger-arg-path: ubiquitinates >nsubj >nn controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: or two mutantt?e1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: , can nott*e2: ents2Label-mention-ngram: , containingte2: trigger: ubiquitinatet"e2: args2Role-mention-ngram: Keap1t*e2: ents2Label-mention-ngram: mutant Keap1t!e2: ents2Label-mention-ngram: onetbe1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttnsubj [lemma='homodimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt#e2: ents2Label-mention-ngram: Keap1t,e2: ents2Label-mention-ngram: Keap1 proteinst?e2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: Keap1 proteinst.e2: ents2Label-mention-ngram: Keap1 proteins ,tte2: trigger-arg-path: Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: containing one ort^e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn controllert$e2: ents2Label-mention-ngram: one ort?e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controllerthe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER dimer ,t?shortest-path: advcl [lemma='ubiquitinate'] >nsubj [lemma='dimer'] >nn [lemma='keap1']t'e2: args2Role-mention-ngram: one or twot*e2: ents2Label-mention-ngram: SHARED dimertVe2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj >nn Gene_or_gene_productt%e2: ents2Label-mention-ngram: dimer ,tte2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='dimer'] >nn [lemma='keap1'] Gene_or_gene_productt&e2: args2Role-mention-ngram: , can nott-e2: args2Role-mention-ngram: two mutant Keap1tse2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controllert+e2: ents2Label-mention-ngram: or two mutanttBe2: trigger-arg-path: ubiquitinate >nsubj >nn Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: one ortae2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttle2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controllert-e2: args2Role-mention-ngram: Keap1 proteins ,t(e2: ents2Label-mention-ngram: one or twot)e2: args2Role-mention-ngram: , containingt.e2: ents2Label-mention-ngram: not ubiquitinatet)e2: args2Role-mention-ngram: mutant Keap1t3e2: ents2Label-mention-ngram: mutant Keap1 proteinst+shortest-path: advcl >nsubj >nnt"e2: args2Role-mention-ngram: , cant5e1: ents2Label-mention-ngram: homodimer ubiquitinatestxe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='homodimer'] >nn [lemma='keap1'] Gene_or_gene_producttWe1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj >nn Gene_or_gene_productt!interceding-token ngrams: , whilete2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='dimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: dimer ,t e2: args2Role-mention-ngram: onetCe1: trigger-arg-path: ubiquitinates >nsubj >nn Gene_or_gene_productt#e2: ents2Label-mention-ngram: , cant%interceding-token ngrams: , while thet^e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn controllertMe1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj >nn controllert9e1: trigger-arg-path: ubiquitinates >nsubj >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn controllert&e1: args2Role-mention-ngram: homodimert-e2: args2Role-mention-ngram: CONTROLLER dimert$e2: ents2Label-mention-ngram: mutantthtrigger-to-trigger-path: e1:ubiquitinates:Positive_regulation >advcl e2:ubiquitinate:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controllert1e2: ents2Label-mention-ngram: ubiquitinate SHAREDt_e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: dimer , containingt%e2: args2Role-mention-ngram: proteinst(e2: ents2Label-mention-ngram: two mutanttnsubj [lemma='dimer'] >nn [lemma='keap1'] controllert'e2: args2Role-mention-ngram: containingtve2: trigger-arg-path: ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: or twot#interceding-token ngrams: while thet'e1: ents2Label-mention-ngram: homodimert/e2: args2Role-mention-ngram: can not CONTROLLEDt2e1: ents2Label-mention-ngram: ubiquitinates SHAREDt.e1: ents2Label-mention-ngram: SHARED homodimertse1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt{e1: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] Gene_or_gene_producttme2: trigger-arg-path: ubiquitinate >nsubj [lemma='dimer'] >nn [lemma='keap1'] controller:Gene_or_gene_productt8e2: trigger-arg-path: ubiquitinate >nsubj >nn controllert)interceding-tokens-full-span: , while thetne1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controllert0e2: ents2Label-mention-ngram: dimer , containingtTe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn Gene_or_gene_producttbe2: trigger-arg-path: ubiquitinate >nsubj [lemma='dimer'] >nn [lemma='keap1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: proteins , cant(e2: ents2Label-mention-ngram: containingtJe1: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj >nn controllert]e1: trigger-arg-path: ubiquitinates >nsubj [lemma='homodimer'] >nn [lemma='keap1'] controllertie2: trigger-arg-path: Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] Gene_or_gene_productt+e2: args2Role-mention-ngram: proteins , cant1e1: args2Role-mention-ngram: CONTROLLER homodimerthe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj >nn Gene_or_gene_productttrigger-to-trigger-path: e1:ubiquitinates:Positive_regulation >advcl [lemma='ubiquitinate'] e2:ubiquitinate:Positive_regulationt-e2: args2Role-mention-ngram: , containing onet!e2: ents2Label-mention-ngram: twot&e2: ents2Label-mention-ngram: proteinst#e2: args2Role-mention-ngram: mutantt?e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='dimer'] >nn [lemma='keap1'] controller:Gene_or_gene_producttme1: trigger-arg-path: Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='homodimer'] >nn [lemma='keap1'] Gene_or_gene_productt"e2: args2Role-mention-ngram: dimert.e2: ents2Label-mention-ngram: two mutant Keap1tMe2: trigger-arg-path: ubiquitinate >nsubj >nn controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: can not ubiquitinatet,e2: ents2Label-mention-ngram: SHARED dimer ,t1e1: ents2Label-mention-ngram: the SHARED mediatedt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='amyloid-beta'] controller:Gene_or_gene_producttge1: trigger-arg-path: Positive_regulation >nsubj [lemma='amyloid-beta'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='amyloid-beta'] controllertTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_producttqtrigger-to-trigger-path: e1:triggers:Positive_regulation >ccomp [lemma='mediate'] e2:mediated:Positive_regulationt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_productt0e2: trigger-arg-path: mediated >nsubj controllertPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] controllertUe1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj controllert[e1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='amyloid-beta'] controllertQe1: trigger-arg-path: triggers >nsubj [lemma='amyloid-beta'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_producttNe2: trigger-arg-path: mediated:Positive_regulation >nsubj Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttTe2: trigger-arg-path: mediated >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='amyloid-beta'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: triggers the SHAREDtKe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT triggers thetEe1: trigger-arg-path: triggers >nsubj controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] controllert_trigger-to-trigger-path: e1:triggers:Positive_regulation >ccomp e2:mediated:Positive_regulationthe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttGe1: trigger-arg-path: triggers >nsubj [lemma='amyloid-beta'] controllert;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT triggerst4e1: args2Role-mention-ngram: triggers the CONTROLLEDtNe1: trigger-arg-path: triggers:Positive_regulation >nsubj Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER triggerstRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='amyloid-beta'] controllertYe1: trigger-arg-path: triggers:Positive_regulation >nsubj controller:Gene_or_gene_productt:e1: trigger-arg-path: triggers >nsubj Gene_or_gene_productt?e2: trigger-arg-path: mediated >nsubj [lemma='jnk1'] controllertZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: mediated phosphorylationtbe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='amyloid-beta'] Gene_or_gene_producttDe1: trigger-arg-path: triggers:Positive_regulation >nsubj controllertAe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj controllert9e1: ents2Label-mention-ngram: mediated phosphorylation oft\e1: trigger-arg-path: triggers >nsubj [lemma='amyloid-beta'] controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='amyloid-beta'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttIe2: trigger-arg-path: mediated >nsubj [lemma='jnk1'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj controller:Gene_or_gene_producttYe2: trigger-arg-path: mediated:Positive_regulation >nsubj controller:Gene_or_gene_producttDe2: trigger-arg-path: mediated:Positive_regulation >nsubj controllert\e1: trigger-arg-path: Positive_regulation >nsubj [lemma='amyloid-beta'] Gene_or_gene_producttSe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] controllert4e1: args2Role-mention-ngram: CONTROLLER triggers thet6e2: ents2Label-mention-ngram: mediated phosphorylationt=e2: ents2Label-mention-ngram: SHARED mediated phosphorylationtle1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='amyloid-beta'] controllert=e1: ents2Label-mention-ngram: SHARED mediated phosphorylationt0e1: trigger-arg-path: triggers >nsubj controllertJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] controllert9e2: ents2Label-mention-ngram: mediated phosphorylation oftEe2: trigger-arg-path: mediated >nsubj controller:Gene_or_gene_producttee1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='amyloid-beta'] Gene_or_gene_producttpe1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='amyloid-beta'] controller:Gene_or_gene_producttVshortest-path: ccomp [lemma='mediate'] >nsubj [lemma='jnk1']t]e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_productt:e2: trigger-arg-path: mediated >nsubj Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubj [lemma='gap'] theme:Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='gap'] themetTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] themet;e2: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] themetCe1: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] themetGe1: trigger-arg-path: Binding >nsubj [lemma='gap'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttKe1: trigger-arg-path: binds >nsubj [lemma='gap'] theme:Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='gap'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_productt;e1: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] themetLe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] themetLe2: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_productt8e1: trigger-arg-path: Binding >nsubj [lemma='gap'] themetKe2: trigger-arg-path: binds >nsubj [lemma='gap'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] themet=e1: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] themet=e2: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] themetSe2: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='gap'] Gene_or_gene_producttPe2: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] themetJe2: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttCe2: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] themetPe1: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] themetLe1: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttRe2: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] themetEe1: trigger-arg-path: binds >nsubj [lemma='gap'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] theme:Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='gap'] themet\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] themetce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='gap'] themetRe2: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttXe2: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='gap'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gap'] theme:Gene_or_gene_producttXe1: trigger-arg-path: binds:Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pdgfrbeta'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gap'] themetRe1: trigger-arg-path: Binding >dobj [lemma='pdgfrbeta'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds:Binding >nsubj [lemma='gap'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: GENERIC_ENTITY functionst/e1: args2Role-mention-ngram: cyclin-D dependenttee2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='cyclin-d'] controllert8e1: ents2Label-mention-ngram: inhibit cyclin-D dependentt\e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controllert1e2: args2Role-mention-ngram: dependent CONTROLLEDt)e1: args2Role-mention-ngram: functions tot?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] controller:Gene_or_gene_producttUe2: trigger-arg-path: Positive_regulation >nn [lemma='cyclin-d'] Gene_or_gene_productt:e1: trigger-arg-path: inhibit nsubj Generic_entitytbe1: trigger-arg-path: Negative_regulation nsubj [lemma='it'] controllertLe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dependent phosphorylationtYe1: trigger-arg-path: inhibit:Negative_regulation nsubj controller:Generic_entityt`e2: trigger-arg-path: Positive_regulation >nn [lemma='cyclin-d'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: cyclin-D dependentt0e1: args2Role-mention-ngram: to inhibit cyclin-Dtqe1: trigger-arg-path: Negative_regulation nsubj [lemma='it'] controller:Generic_entitytme2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] controllertHe2: trigger-arg-path: phosphorylation:Positive_regulation >nn controllertFe1: trigger-arg-path: Negative_regulation nsubj Generic_entityt2e1: ents2Label-mention-ngram: functions to inhibitt4e2: trigger-arg-path: phosphorylation >nn controllertBe1: trigger-arg-path: Negative_regulation nsubj controllertPe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn Gene_or_gene_producttxshortest-path: xcomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] >nn [lemma='cyclin-d']t&e1: args2Role-mention-ngram: functionst@e1: ents2Label-mention-ngram: cyclin-D dependent phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='it'] Generic_entitytLe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj Generic_entitytZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn controllert|e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='it'] controllertNe1: trigger-arg-path: inhibit:Negative_regulation nsubj Generic_entityt%e1: args2Role-mention-ngram: cyclin-Dt*e1: ents2Label-mention-ngram: functions tot:e2: ents2Label-mention-ngram: dependent phosphorylation oft]e2: trigger-arg-path: phosphorylation:Positive_regulation >nn controller:Gene_or_gene_producttQe2: trigger-arg-path: phosphorylation >nn [lemma='cyclin-d'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: cyclin-Dtle1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='it'] Generic_entitytee1: trigger-arg-path: inhibit nsubj [lemma='it'] controller:Generic_entityt1e1: args2Role-mention-ngram: functions to inhibittEe1: trigger-arg-path: inhibit nsubj controller:Generic_entitytwe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='it'] controller:Generic_entitytnn [lemma='cyclin-d'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controller:Generic_entitytye1: trigger-arg-path: inhibit:Negative_regulation nsubj [lemma='it'] controller:Generic_entitytde2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controller:Generic_entitythe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='it'] controllert\e2: trigger-arg-path: phosphorylation >nn [lemma='cyclin-d'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER functionst.e1: ents2Label-mention-ngram: inhibit cyclin-Dt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='it'] controller:Generic_entitytne1: trigger-arg-path: inhibit:Negative_regulation nsubj [lemma='it'] Generic_entityt'e1: ents2Label-mention-ngram: functionst:e1: args2Role-mention-ngram: cyclin-D dependent CONTROLLEDtJe1: trigger-arg-path: inhibit:Negative_regulation nsubj controllertKe2: trigger-arg-path: Positive_regulation >nn [lemma='cyclin-d'] controllert7e2: ents2Label-mention-ngram: dependent phosphorylationt&e1: args2Role-mention-ngram: dependentt[e2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] controllert&shortest-path: xcomp >dobj >nntne2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='cyclin-d'] controller:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn controllertVe1: trigger-arg-path: inhibit nsubj [lemma='it'] controllertGe2: trigger-arg-path: phosphorylation >nn [lemma='cyclin-d'] controllert(e1: ents2Label-mention-ngram: to inhibitt7e1: args2Role-mention-ngram: inhibit cyclin-D dependenttwe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] Gene_or_gene_producttRe2: trigger-arg-path: phosphorylation:Positive_regulation >nn Gene_or_gene_producttQe1: trigger-arg-path: Negative_regulation nsubj controller:Generic_entitytHe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controllert6e1: trigger-arg-path: inhibit nsubj controllertdtrigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj e2:phosphorylation:Positive_regulationtZe1: trigger-arg-path: inhibit nsubj [lemma='it'] Generic_entitytje1: trigger-arg-path: inhibit:Negative_regulation nsubj [lemma='it'] controllert7e1: ents2Label-mention-ngram: dependent phosphorylationt-e1: args2Role-mention-ngram: inhibit cyclin-Dt1e1: args2Role-mention-ngram: dependent CONTROLLEDt4e1: args2Role-mention-ngram: CONTROLLER functions tot>e2: trigger-arg-path: phosphorylation >nn Gene_or_gene_productt~trigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtIe2: trigger-arg-path: phosphorylation >nn controller:Gene_or_gene_producttfe1: trigger-arg-path: Negative_regulation nsubj [lemma='it'] Generic_entityt1e1: ents2Label-mention-ngram: to inhibit cyclin-Dt'e1: args2Role-mention-ngram: to inhibitt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj Generic_entitytpe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='cyclin-d'] controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: GENERIC_ENTITY functions tot:e1: ents2Label-mention-ngram: dependent phosphorylation oftKe1: trigger-arg-path: mediated:Positive_regulation >ccomp >nsubj controlledtse1: trigger-arg-path: mediated >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtke2: trigger-arg-path: enhances nsubj [lemma='ck2'] controller:Positive_regulationt2e2: ents2Label-mention-ngram: phosphorylation alsotce1: trigger-arg-path: mediated >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlledt@e2: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlledt0e1: args2Role-mention-ngram: mediated CONTROLLEDt4e2: ents2Label-mention-ngram: SHARED mediated SHAREDt5e2: args2Role-mention-ngram: also enhances CONTROLLEDtqtrigger-to-trigger-path: e1:mediated:Positive_regulation >ccomp [lemma='enhance'] e2:enhances:Positive_regulationt]e2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] UbiquitinationtTe2: trigger-arg-path: enhances:Positive_regulation nsubj Positive_regulationt0e1: args2Role-mention-ngram: CONTROLLER mediatedtye1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] PhosphorylationtVe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:Gene_or_gene_producttCe2: trigger-arg-path: enhances:Positive_regulation >dobj controlledt`e2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationtccomp >nsubj Phosphorylationt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck2'] controller:Gene_or_gene_productt'shortest-path: nsubj Positive_regulationt=e2: ents2Label-mention-ngram: mediated SHARED phosphorylationtxe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ck2'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj Positive_regulationtWe2: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] controlled:UbiquitinationtYe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] controlledtRe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ck2'] controllert;e2: ents2Label-mention-ngram: phosphorylation also enhancestke2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='ck2'] controllertBe1: trigger-arg-path: Positive_regulation >ccomp >nsubj controlledt~e1: trigger-arg-path: Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtce2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlled:Ubiquitinationthe1: trigger-arg-path: mediated >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] PhosphorylationtNe1: trigger-arg-path: mediated:Positive_regulation >nsubj Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj controller:Positive_regulationtXe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlledtSe1: trigger-arg-path: mediated >nsubj [lemma='ck2'] controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] controlledtge1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ck2'] controller:Gene_or_gene_producttRe1: trigger-arg-path: Positive_regulation >ccomp >nsubj controlled:Phosphorylationt%e1: args2Role-mention-ngram: mediatedtae1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >nsubj PhosphorylationtKe2: trigger-arg-path: Positive_regulation nsubj Positive_regulationt3e2: trigger-arg-path: enhances >dobj UbiquitinationtEe1: trigger-arg-path: mediated >nsubj controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: also enhances SHAREDtMe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] Phosphorylationtpe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj controller:Positive_regulationtGe1: trigger-arg-path: Positive_regulation >ccomp >nsubj Phosphorylationtqe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ck2'] Positive_regulationt_e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj Gene_or_gene_producttwe1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlledtje1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='ck2'] controller:Positive_regulationtKe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj Gene_or_gene_productt*e2: args2Role-mention-ngram: also enhancestHe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj controllert5e2: args2Role-mention-ngram: CONTROLLER also enhancestke2: trigger-arg-path: Positive_regulation nsubj [lemma='ck2'] Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ck2'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: alsot|e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ck2'] controller:Positive_regulationtse1: trigger-arg-path: Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] PhosphorylationtTe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlledtHe2: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] controlledtDe1: trigger-arg-path: mediated:Positive_regulation >nsubj controllert_e2: trigger-arg-path: enhances:Positive_regulation nsubj controller:Positive_regulationt?e1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtne1: trigger-arg-path: Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlledtnsubj [lemma='ck2'] Gene_or_gene_productt:e1: trigger-arg-path: mediated >nsubj Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck2'] Gene_or_gene_productte1: trigger: mediatedtKe2: trigger-arg-path: enhances nsubj controller:Positive_regulationtce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ck2'] controllertVe2: trigger-arg-path: Positive_regulation nsubj controller:Positive_regulationthe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt7e1: trigger-arg-path: mediated >ccomp >nsubj controlledt\e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj controllertIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck2'] controllertWe2: trigger-arg-path: enhances nsubj [lemma='ck2'] controllertbe2: trigger-arg-path: Positive_regulation nsubj [lemma='ck2'] controllertXe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj controlled:Phosphorylationt9e2: ents2Label-mention-ngram: SHARED phosphorylation alsot>e2: trigger-arg-path: enhances >dobj controlled:Ubiquitinationt|e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt>e1: trigger-arg-path: mediated >nsubj [lemma='ck2'] controllert4e1: ents2Label-mention-ngram: SHARED mediated SHAREDtGe1: trigger-arg-path: mediated >ccomp >nsubj controlled:Phosphorylationt\e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ck2'] Gene_or_gene_producttve2: trigger-arg-path: Positive_regulation nsubj [lemma='ck2'] controller:Positive_regulationtOe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlled:Ubiquitinationt+e2: ents2Label-mention-ngram: also enhancestGe2: trigger-arg-path: enhances:Positive_regulation >dobj UbiquitinationtOe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ck2'] controllertqe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] UbiquitinationtLe2: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] UbiquitinationtYe1: trigger-arg-path: mediated:Positive_regulation >nsubj controller:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj controlledt0e1: trigger-arg-path: mediated >nsubj controllert-e1: ents2Label-mention-ngram: mediated SHAREDt\e2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] controlledtte2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='ck2'] Positive_regulationtPe1: trigger-arg-path: mediated:Positive_regulation >ccomp >nsubj Phosphorylationt@e2: trigger-arg-path: enhances nsubj Positive_regulationte2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='ck2'] controller:Positive_regulationt\e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >nsubj controlledt/e2: trigger-arg-path: enhances >dobj controlledtte1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlledtBe2: trigger-arg-path: Positive_regulation nsubj controllert[e1: trigger-arg-path: mediated:Positive_regulation >ccomp >nsubj controlled:Phosphorylationthe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ck2'] controllert,e2: args2Role-mention-ngram: CONTROLLER alsot?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='ck2'] Positive_regulationt|e1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] Phosphorylationt`e2: trigger-arg-path: enhances nsubj [lemma='ck2'] Positive_regulationt;e1: args2Role-mention-ngram: CONTROLLER mediated CONTROLLEDtme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ck2'] Gene_or_gene_producttRe2: trigger-arg-path: enhances:Positive_regulation >dobj controlled:UbiquitinationtYe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ck2'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='ck2'] controllert_trigger-to-trigger-path: e1:mediated:Positive_regulation >ccomp e2:enhances:Positive_regulationt"e2: ents2Label-mention-ngram: alsotle1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >nsubj controlled:PhosphorylationtAe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controllertke2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='enhance'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationt=e1: ents2Label-mention-ngram: mediated SHARED phosphorylationt7e2: trigger-arg-path: enhances nsubj controllertDe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj UbiquitinationtKe2: trigger-arg-path: enhances:Positive_regulation nsubj controllertUe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controllert-e1: ents2Label-mention-ngram: SHARED may alsot e1: args2Role-mention-ngram: maytDe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:Familyt,e1: trigger-arg-path: interact >nsubj FamilytHe2: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] theme:Familytke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] themetFe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Familyt_e1: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] themet\e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] themetBe1: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] themet(e2: ents2Label-mention-ngram: SHARED mayt>e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj Familyt4e2: trigger-arg-path: interact:Binding >nsubj Familyt e2: args2Role-mention-ngram: maytVe1: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: may also directlyt?e1: trigger-arg-path: Binding >nsubj [lemma='tax'] theme:FamilytKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] themet:e1: trigger-arg-path: interact >nsubj [lemma='tax'] FamilytRe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] theme:Familyt.e1: args2Role-mention-ngram: may also directlyt@e2: trigger-arg-path: interact >nsubj [lemma='tax'] theme:Familyt2e2: trigger-arg-path: interact >nsubj theme:Familyt+e1: args2Role-mention-ngram: THEME may alsotVe2: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: directly interact witht*e1: args2Role-mention-ngram: also directlytZe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] theme:FamilytHe1: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] theme:Familyt4e2: ents2Label-mention-ngram: also directly interacttLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] Familyt,e2: trigger-arg-path: interact >nsubj FamilytKe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] themet8e2: trigger-arg-path: Binding >nsubj [lemma='tax'] themet/e2: ents2Label-mention-ngram: directly interacttJe2: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] themet*e2: args2Role-mention-ngram: also directlyt@e1: trigger-arg-path: interact >nsubj [lemma='tax'] theme:Familyt9e1: trigger-arg-path: Binding >nsubj [lemma='tax'] FamilytAe1: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] themetWe2: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding >nsubj [lemma='tax'] theme:FamilytLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] Familyt.e1: args2Role-mention-ngram: directly interacttAe1: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] themetJe1: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] themetYe1: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_productt;shortest-path: aux [lemma='may']t>e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj Familyt9e1: trigger-arg-path: interact >nsubj [lemma='tax'] themetTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] Familytce1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] Gene_or_gene_productt2e1: trigger-arg-path: interact >nsubj theme:Familytie1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED may alsot+e2: ents2Label-mention-ngram: also directlytAe2: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] themetFe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Familyt(e1: ents2Label-mention-ngram: SHARED mayt3e1: args2Role-mention-ngram: directly interact withtqe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Familytqe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: also directly interacttYe2: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: also directly interacttTe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] themet:e2: trigger-arg-path: interact >nsubj [lemma='tax'] Familyt/e1: ents2Label-mention-ngram: may also directlyt!e1: ents2Label-mention-ngram: maytQe2: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] Gene_or_gene_productt_e2: trigger-arg-path: interact:Binding >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt4e1: trigger-arg-path: interact:Binding >nsubj FamilytPe2: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_productt&e2: args2Role-mention-ngram: THEME maytTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] Familyt9e2: trigger-arg-path: interact >nsubj [lemma='tax'] themet&e1: args2Role-mention-ngram: THEME mayt%e2: args2Role-mention-ngram: may alsot:e1: trigger-arg-path: interact:Binding >nsubj theme:FamilytDe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:FamilytPe1: trigger-arg-path: Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_productt3e2: args2Role-mention-ngram: directly interact witht9e2: trigger-arg-path: Binding >nsubj [lemma='tax'] Familyt3e2: args2Role-mention-ngram: also directly interactt8e1: trigger-arg-path: Binding >nsubj [lemma='tax'] themetAe2: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] themetSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] themetie2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: may alsotTe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ikkalpha'] themet/e1: ents2Label-mention-ngram: directly interacttRe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tax'] theme:Familyt+e1: ents2Label-mention-ngram: also directlyt4e1: ents2Label-mention-ngram: directly interact withtBe2: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] FamilytWe1: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ikkalpha'] Gene_or_gene_productt+e2: args2Role-mention-ngram: THEME may alsot&e1: ents2Label-mention-ngram: may alsotQe1: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Familyt&e2: ents2Label-mention-ngram: may alsotBe2: trigger-arg-path: interact >prep_with [lemma='ikkalpha'] themet!e2: ents2Label-mention-ngram: mayt.e2: args2Role-mention-ngram: may also directlyt.e2: args2Role-mention-ngram: directly interacttBe1: trigger-arg-path: interact:Binding >nsubj [lemma='tax'] Familyt:e2: trigger-arg-path: interact:Binding >nsubj theme:FamilytZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tax'] theme:FamilytZe2: trigger-arg-path: stimulates:Positive_activation >dobj controlled:Gene_or_gene_productt5e1: trigger-arg-path: binds >dobj [lemma='pak'] themet8e1: ents2Label-mention-ngram: binds GENE_OR_GENE_PRODUCTt0e2: ents2Label-mention-ngram: but also interactstEe2: trigger-arg-path: stimulates:Positive_activation >dobj controlledtTe2: trigger-arg-path: stimulates >dobj [lemma='rac'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: stimulates:Positive_activation nsubj [lemma='rac'] Complext8e1: trigger-arg-path: Binding >nsubj [lemma='rac'] themet$e2: ents2Label-mention-ngram: only at>e1: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] themetLe1: trigger-arg-path: Binding >dobj [lemma='pak'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: effector butt`e2: trigger-arg-path: stimulates:Positive_activation nsubj controller:Complext`e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlled:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj controllertLe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj controlledt?e2: trigger-arg-path: stimulates >dobj [lemma='rac'] controlledtGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] themet,e2: ents2Label-mention-ngram: also interactst7e1: trigger-arg-path: Binding >dobj [lemma='pak'] themetHe2: trigger-arg-path: Positive_activation >dobj [lemma='rac'] controlledtXe2: trigger-arg-path: stimulates:Positive_activation nsubj controllertOe2: trigger-arg-path: stimulates:Positive_activation >dobj Gene_or_gene_productt)e2: ents2Label-mention-ngram: binds PAK ,tke2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: a Rac effectort#e2: ents2Label-mention-ngram: PAK ,t*e2: ents2Label-mention-ngram: Rac effectortOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] themet|e2: trigger-arg-path: Positive_activation nsubj [lemma='rac'] controllertLe1: trigger-arg-path: binds:Binding >dobj [lemma='pak'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='rac'] controllert0e2: ents2Label-mention-ngram: in turn stimulatest?trigger-to-trigger-path: e1:binds:Binding >conj_but [lemma='interact'] >prep_with [lemma='pix'] >rcmod [lemma='stimulate'] e2:stimulates:Positive_activationt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pak'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: stimulates SHAREDtRe2: trigger-arg-path: Positive_activation >dobj [lemma='rac'] Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='pak'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: in turn stimulatestce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pak'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: turn stimulatest?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj [lemma='rac'] controllertNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pak'] themet\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: stimulatestFe1: trigger-arg-path: Binding >dobj [lemma='pak'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: is nott?e1: ents2Label-mention-ngram: SHARED binds GENE_OR_GENE_PRODUCTt]e2: trigger-arg-path: Positive_activation >dobj [lemma='rac'] controlled:Gene_or_gene_productt;e2: trigger-arg-path: stimulates >dobj Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: stimulatestse2: trigger-arg-path: stimulates nsubj [lemma='rac'] controllertFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pak'] themet?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='rac'] controller:Complext?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj [lemma='rac'] controller:Complext4e2: ents2Label-mention-ngram: turn stimulates SHAREDt!e2: ents2Label-mention-ngram: RactVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] Gene_or_gene_productt=e1: trigger-arg-path: binds:Binding >dobj [lemma='pak'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt]e2: trigger-arg-path: stimulates:Positive_activation >dobj [lemma='rac'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj Complext6e1: trigger-arg-path: binds >nsubj [lemma='rac'] themetAe2: trigger-arg-path: stimulates nsubj ComplextMe1: trigger-arg-path: Binding >nsubj [lemma='rac'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='rac'] controlledt&e2: ents2Label-mention-ngram: but alsotLe2: trigger-arg-path: stimulates nsubj controller:Complextpe2: trigger-arg-path: stimulates nsubj [lemma='rac'] Complext9e2: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCT ,tne2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='rac'] Gene_or_gene_producttDe1: trigger-arg-path: binds >dobj [lemma='pak'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: also interacts withtPe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='rac'] controlledtUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pak'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation nsubj ComplextBe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlledt?e2: trigger-arg-path: Positive_activation nsubj [lemma='rac'] controller:Complextqe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj controller:Complext.e2: ents2Label-mention-ngram: SHARED binds PAKt,e2: args2Role-mention-ngram: turn stimulatest(e2: ents2Label-mention-ngram: only a Ract(e2: ents2Label-mention-ngram: , which ist?e2: trigger-arg-path: stimulates:Positive_activation nsubj [lemma='rac'] controller:Complexte2: trigger: stimulatest^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] Gene_or_gene_producttEe1: trigger-arg-path: binds >nsubj [lemma='rac'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='rac'] controlled:Gene_or_gene_productt&e2: ents2Label-mention-ngram: which istye2: trigger-arg-path: Positive_activation nsubj [lemma='rac'] Complext.e2: ents2Label-mention-ngram: Rac effector butt]e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controller:Complext1e2: trigger-arg-path: stimulates >dobj controlledt(e2: ents2Label-mention-ngram: not only atMe1: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: PAKt'e2: ents2Label-mention-ngram: binds PAKtAe2: ents2Label-mention-ngram: interacts with GENE_OR_GENE_PRODUCTtSe2: trigger-arg-path: stimulates:Positive_activation >dobj [lemma='rac'] controlledt{e2: trigger-arg-path: stimulates nsubj [lemma='rac'] controller:Complext&e2: ents2Label-mention-ngram: effectort?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj [lemma='rac'] Complext2e2: args2Role-mention-ngram: stimulates CONTROLLEDtUe2: trigger-arg-path: Positive_activation nsubj controller:Complext7e2: args2Role-mention-ngram: turn stimulates CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='rac'] ComplextUe2: trigger-arg-path: stimulates:Positive_activation nsubj ComplextZe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='rac'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: a RactKe1: trigger-arg-path: binds >nsubj [lemma='rac'] theme:Gene_or_gene_producttIe2: trigger-arg-path: stimulates >dobj [lemma='rac'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pak'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: is not onlytfe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj ComplextRe1: trigger-arg-path: binds:Binding >dobj [lemma='pak'] theme:Gene_or_gene_productt?e2: trigger-arg-path: stimulates:Positive_activation nsubj [lemma='rac'] controllert/e2: ents2Label-mention-ngram: effector but alsotGe1: trigger-arg-path: Binding >nsubj [lemma='rac'] Gene_or_gene_productthe2: trigger-arg-path: stimulates:Positive_activation >dobj [lemma='rac'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: PAK , whichtMe2: trigger-arg-path: Positive_activation nsubj controllertgtrigger-to-trigger-path: e1:binds:Binding >conj_but >prep_with >rcmod e2:stimulates:Positive_activationt*e2: ents2Label-mention-ngram: which is nottUe2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controllertye2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='rac'] controlled:Gene_or_gene_producttDe2: trigger-arg-path: stimulates nsubj controllertFe2: trigger-arg-path: stimulates >dobj controlled:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mtorc2'] themet]e2: trigger-arg-path: complexes:Binding e2: trigger-arg-path: Binding nn themet{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='pras40'] controller:Gene_or_gene_producttHe2: trigger-arg-path: complexes:Binding dobj >nn Gene_or_gene_producttWe2: trigger-arg-path: complexes:Binding dobj >nn controlled:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtorc2'] Gene_or_gene_producttBe2: trigger-arg-path: complexes:Binding >nn [lemma='mtorc2'] themetje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:Gene_or_gene_producttDe2: trigger-arg-path: complexes nsubj [lemma='pras40'] controllert?e1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: Negative_activation >dobj >nn controlled:Gene_or_gene_productt+interceding-token ngrams: was identified totLe2: trigger-arg-path: complexes:Binding nsubj Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex xcomp [lemma='interact'] >prep_with [lemma='mtor'] >prep_in [lemma='complex'] e2:complexes:Bindingt$interceding-token ngrams: DEPTOR wast,interceding-token ngrams: directly with mTORt>e2: trigger-arg-path: complexes >nn theme:Gene_or_gene_productt0interceding-token ngrams: identified to interactt8e2: trigger-arg-path: complexes >nn Gene_or_gene_producttIe2: trigger-arg-path: complexes >nn [lemma='mtorc2'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlledt!interceding-token ngrams: mTOR intWe1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlledtMe2: trigger-arg-path: Binding nn [lemma='mtorc2'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: and THEME complexestinterceding-token ngrams: bothtpinterceding-tokens-full-span: activity via raptor , DEPTOR was identified to interact directly with mTOR in bothtMe2: trigger-arg-path: Binding >nn [lemma='mtorc2'] theme:Gene_or_gene_producttFe2: trigger-arg-path: complexes:Binding >nn theme:Gene_or_gene_producttDe1: trigger-arg-path: inhibits:Negative_activation >nsubj controllertee2: trigger-arg-path: lemmatizedTrigger=complex dobj >nn Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=complex:Binding dobj [lemma='activity'] >nn [lemma='mtorc1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: inhibits thetre1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='mtorc1'] Gene_or_gene_producttUe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='pras40'] controllertSe2: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='mtorc1'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtorc2'] theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: inhibits the CONTROLLEDtme2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj Gene_or_gene_producttYe1: trigger-arg-path: inhibits:Negative_activation >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: interacttotrigger-to-trigger-path: e1:inhibits:Negative_activation xcomp >prep_with >prep_in e2:complexes:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlled:Gene_or_gene_producttke1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlledtinterceding-token ngrams: viat,e2: args2Role-mention-ngram: THEME complexest interceding-token ngrams: DEPTORt@e2: trigger-arg-path: complexes:Binding >nn Gene_or_gene_productt(interceding-token ngrams: was identifiedtfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='pras40'] controllert_e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='mtorc2'] themet7shortest-path: xcomp >prep_with >prep_intbe1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlledtLe1: trigger-arg-path: Negative_activation >nsubj [lemma='pras40'] controllertUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] Gene_or_gene_productt>e2: trigger-arg-path: complexes nsubj Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlled:Gene_or_gene_productt&interceding-token ngrams: with mTOR intVe1: trigger-arg-path: Negative_activation >nsubj [lemma='pras40'] Gene_or_gene_productt?shortest-path: xcomp [lemma='interact'] >prep_with [lemma='mtor'] >prep_in [lemma='mtorc1']t&e2: args2Role-mention-ngram: complexestme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlled:Gene_or_gene_producttae1: trigger-arg-path: Negative_activation >nsubj [lemma='pras40'] controller:Gene_or_gene_productt'interceding-token ngrams: identified totOe2: trigger-arg-path: complexes nsubj controller:Gene_or_gene_productt#interceding-token ngrams: with mTORt:e2: trigger-arg-path: complexes >nn [lemma='mtorc2'] themet?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibits thet/interceding-token ngrams: DEPTOR was identifiedt"interceding-token ngrams: raptor ,tFe2: trigger-arg-path: complexes:Binding nn [lemma='mtorc2'] theme:Gene_or_gene_producttje1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='pras40'] controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlledtYe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mtorc2'] Gene_or_gene_productt0interceding-token ngrams: interact directly withtle1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlled:Gene_or_gene_producttEe1: trigger-arg-path: inhibits >nsubj controller:Gene_or_gene_productt7e2: trigger-arg-path: complexes:Binding nsubj [lemma='pras40'] Gene_or_gene_productt/e2: trigger-arg-path: complexes nsubj controllertge1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pras40'] controller:Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlledt-interceding-token ngrams: activity via raptort)interceding-token ngrams: raptor , DEPTORt_e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj Gene_or_gene_productt1e2: trigger-arg-path: complexes:Binding >nn themet&interceding-token ngrams: , DEPTOR wast|e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='mtorc1'] controlledt3e1: trigger-arg-path: inhibits >dobj >nn controlledtQe2: trigger-arg-path: complexes:Binding >nn [lemma='mtorc2'] Gene_or_gene_productt@e2: trigger-arg-path: complexes dobj >nn Gene_or_gene_producttOe2: trigger-arg-path: complexes >nn [lemma='mtorc2'] theme:Gene_or_gene_productt!interceding-token ngrams: in botht"interceding-token ngrams: directlyt1e1-label: Negative_activation + e2-label: Bindingt interceding-token ngrams: raptort_e1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='pras40'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtorc2'] themetae1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='mtorc1'] Gene_or_gene_producttVe1: trigger-arg-path: inhibits >nsubj [lemma='pras40'] controller:Gene_or_gene_producttHe1: trigger-arg-path: inhibits >dobj >nn controlled:Gene_or_gene_producttAe1: trigger-arg-path: inhibits >nsubj [lemma='pras40'] controllertGe1: trigger-arg-path: inhibits:Negative_activation >dobj >nn controlledtKe1: trigger-arg-path: inhibits >nsubj [lemma='pras40'] Gene_or_gene_productt&interceding-token ngrams: mTOR in bothtdobj [lemma='activity'] >nn [lemma='mtorc1'] controlled:Gene_or_gene_productt@e2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT complexestXe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dobj [lemma='activity'] >nn [lemma='mtorc1'] controlled:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='pras40'] Gene_or_gene_productt&interceding-token ngrams: via raptor ,tbe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn Gene_or_gene_producttGe2: trigger-arg-path: Binding >nn [lemma='mtorc2'] Gene_or_gene_productt:e1: trigger-arg-path: hydroxylated nn Hydroxylationtte2: trigger-arg-path: Positive_regulation nn [lemma='vhl'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: promotes thete1: trigger: hydroxylatedt.e2: ents2Label-mention-ngram: , which promotest4e2: ents2Label-mention-ngram: the polyubiquitinationtVe1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn controlled:HydroxylationtYe1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent controllert0e2: ents2Label-mention-ngram: polyubiquitinationtle1: trigger-arg-path: hydroxylated nn [lemma='hif-1alpha'] controlled:Hydroxylationt_e1: trigger-arg-path: Positive_regulation >agent [lemma='pdh2'] controller:Gene_or_gene_producttee1: trigger-arg-path: Positive_regulation nn [lemma='hif-1alpha'] controlledtZe1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent controller:Gene_or_gene_producttytrigger-to-trigger-path: e1:hydroxylated:Positive_regulation prep_to >rcmod e2:promotes:Positive_regulationtWe1: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='pdh2'] controllertTe1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='pdh2'] controllertMe1: trigger-arg-path: hydroxylated >agent [lemma='pdh2'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: protein , whicht}e2: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] controller:Gene_or_gene_producttIe1: trigger-arg-path: hydroxylated >agent controller:Gene_or_gene_producttYe1: trigger-arg-path: hydroxylated:Positive_regulation nn controlled:Hydroxylationt}e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='pdh2'] controller:Gene_or_gene_productt)interceding-tokens-full-span: can bind tot^e1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='pdh2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn [lemma='hif-1alpha'] controlledtye2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] controllerte1: trigger-arg-path: Positive_regulation nn controlledt4e2: args2Role-mention-ngram: promotes the CONTROLLEDt(e2: ents2Label-mention-ngram: HIF-1alphat\e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn controlledt3e2: ents2Label-mention-ngram: polyubiquitination oft^e1: trigger-arg-path: hydroxylated nn [lemma='hif-1alpha'] controlledtKe1: trigger-arg-path: hydroxylated:Positive_regulation nn controlledtze2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] controller:Gene_or_gene_productt?e1: trigger-arg-path: hydroxylated:Positive_regulation nn [lemma='hif-1alpha'] controlled:Hydroxylationt}e1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn [lemma='hif-1alpha'] controlled:Hydroxylationt)e2: args2Role-mention-ngram: promotes thet,e2: args2Role-mention-ngram: protein , whichtje1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn controlled:Hydroxylationt*e1: ents2Label-mention-ngram: hydroxylatedtTe1: trigger-arg-path: Positive_regulation >agent [lemma='pdh2'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: the polyubiquitination oft1e2: args2Role-mention-ngram: CONTROLLER protein ,tEe1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] controller:Gene_or_gene_productt=e2: ents2Label-mention-ngram: promotes the polyubiquitinationtHe1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn controlledt^e2: trigger-arg-path: promotes nn [lemma='vhl'] Gene_or_gene_productt-e2: args2Role-mention-ngram: , which promotestEe1: trigger-arg-path: hydroxylated nn controlled:Hydroxylationt+e2: ents2Label-mention-ngram: of HIF-1alphat?e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn [lemma='hif-1alpha'] controlled:HydroxylationtNe1: trigger-arg-path: hydroxylated:Positive_regulation nn Hydroxylationthe2: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] controllertoe2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent Gene_or_gene_producttie2: trigger-arg-path: Positive_regulation nn [lemma='vhl'] Gene_or_gene_producttinterceding-token ngrams: cant+e2: args2Role-mention-ngram: which promotest,e2: ents2Label-mention-ngram: which promotest?trigger-to-trigger-path: e1:hydroxylated:Positive_regulation prep_to [lemma='protein'] >rcmod [lemma='promote'] e2:promotes:Positive_regulationt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT proteintgshortest-path: prep_to [lemma='protein'] >nn [lemma='vhl']the1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='pdh2'] controllert4e1: ents2Label-mention-ngram: SHARED hydroxylated bytre1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='pdh2'] Gene_or_gene_producttre2: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] Gene_or_gene_productt4e1: trigger-arg-path: hydroxylated >agent controllertie1: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='pdh2'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: of HIF-1alpha andt3e2: ents2Label-mention-ngram: HIF-1alpha and SHAREDtCe1: trigger-arg-path: hydroxylated >agent [lemma='pdh2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn [lemma='hif-1alpha'] Hydroxylationt0e2: ents2Label-mention-ngram: which promotes thet'e2: ents2Label-mention-ngram: protein ,tse1: trigger-arg-path: Positive_regulation nn [lemma='hif-1alpha'] controlled:Hydroxylationt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] Gene_or_gene_producttae1: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='pdh2'] Gene_or_gene_producttre1: trigger-arg-path: hydroxylated:Positive_regulation nn [lemma='hif-1alpha'] controlledtue1: trigger-arg-path: hydroxylated:Positive_regulation nn [lemma='hif-1alpha'] Hydroxylationt/e2: args2Role-mention-ngram: which promotes thetAe1: trigger-arg-path: Positive_regulation nn HydroxylationtJe1: trigger-arg-path: Positive_regulation >agent [lemma='pdh2'] controllert,e2: ents2Label-mention-ngram: HIF-1alpha andtie2: trigger-arg-path: promotes nn [lemma='vhl'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation nn [lemma='vhl'] controllertLe1: trigger-arg-path: Positive_regulation nn controlled:Hydroxylationtle1: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='pdh2'] controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn Hydroxylationt-e1: ents2Label-mention-ngram: hydroxylated bytXe1: trigger-arg-path: hydroxylated >agent [lemma='pdh2'] controller:Gene_or_gene_producttRe1: trigger-arg-path: hydroxylated:Positive_regulation >agent Gene_or_gene_producttinterceding-token ngrams: bindt>e2: ents2Label-mention-ngram: polyubiquitination of HIF-1alphat"interceding-token ngrams: can bindtre1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn [lemma='hif-1alpha'] Hydroxylationt&shortest-path: prep_to >nntHe1: trigger-arg-path: hydroxylated:Positive_regulation >agent controllert1e1: ents2Label-mention-ngram: SHARED hydroxylatedt!interceding-token ngrams: bind tot&e2: args2Role-mention-ngram: protein ,the1: trigger-arg-path: Positive_regulation nn [lemma='hif-1alpha'] Hydroxylationtce1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent Gene_or_gene_producttTe2: trigger-arg-path: promotes nn [lemma='vhl'] controllertBe1: ents2Label-mention-ngram: hydroxylated by GENE_OR_GENE_PRODUCTt/e2: args2Role-mention-ngram: CONTROLLER proteintoe1: trigger-arg-path: lemmatizedTrigger=hydroxylate nn [lemma='hif-1alpha'] controlledt]e1: trigger-arg-path: hydroxylated:Positive_regulation >agent controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation nn Hydroxylationtee2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] controllert>e1: trigger-arg-path: hydroxylated >agent Gene_or_gene_producttae1: trigger-arg-path: hydroxylated nn [lemma='hif-1alpha'] Hydroxylationt7e1: trigger-arg-path: hydroxylated nn controlledt%interceding-token ngrams: can bind totJe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] themet2e2: ents2Label-mention-ngram: and translocates thetve2: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt5e2: trigger-arg-path: interacts:Binding >nsubj Familytpe2: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_productt+e2: args2Role-mention-ngram: the serine andtYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] theme:Familyt,e2: ents2Label-mention-ngram: the serine andtTe1: trigger-arg-path: Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] themet9e2: ents2Label-mention-ngram: kinase GENE_OR_GENE_PRODUCTt3e2: trigger-arg-path: interacts >nsubj theme:Familyt[e1: trigger-arg-path: Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] theme:Familyt3e2: ents2Label-mention-ngram: with and translocatest/e2: ents2Label-mention-ngram: threonine proteint1e2: args2Role-mention-ngram: protein kinase THEMEt#e2: args2Role-mention-ngram: serinet2e2: args2Role-mention-ngram: and threonine proteint5e2: args2Role-mention-ngram: threonine protein kinasetke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] themet9e2: trigger-arg-path: interacts >nsubj [lemma='ra'] themetKe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] Familyt@e2: trigger-arg-path: interacts >nsubj [lemma='ra'] theme:Familyt'e2: ents2Label-mention-ngram: threoninetRe1: trigger-arg-path: bound >ccomp [lemma='translocate'] >nsubj [lemma='ra'] themet&e2: args2Role-mention-ngram: threoninetre1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] theme:Familyt;e2: trigger-arg-path: interacts:Binding >nsubj theme:FamilytYe1: trigger-arg-path: bound >ccomp [lemma='translocate'] >nsubj [lemma='ra'] theme:Familytle2: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet.e2: ents2Label-mention-ngram: and translocatestXtrigger-to-trigger-path: e1:bound:Binding >ccomp [lemma='interact'] e2:interacts:BindingtYe2: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] themetae2: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet4e2: args2Role-mention-ngram: translocates the serinetce1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='translocate'] >nsubj [lemma='ra'] themet.e2: ents2Label-mention-ngram: translocates thetBe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] FamilytAe2: ents2Label-mention-ngram: protein kinase GENE_OR_GENE_PRODUCTtae1: trigger-arg-path: bound:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] theme:FamilytSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] Familyt[e1: trigger-arg-path: bound:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] Familythe2: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_producttfe2: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] FamilytQe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] theme:Familyt:e2: trigger-arg-path: interacts >nsubj [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_producttHe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] theme:FamilytEtrigger-to-trigger-path: e1:bound:Binding >ccomp e2:interacts:Bindingt*e2: args2Role-mention-ngram: and threoninetZe1: trigger-arg-path: bound:Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] themetne2: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt5e2: ents2Label-mention-ngram: translocates the serinet-e2: args2Role-mention-ngram: and translocatestUe1: trigger-arg-path: Binding >ccomp [lemma='translocate'] >nsubj [lemma='ra'] Familyt*e2: ents2Label-mention-ngram: translocatest(e2: ents2Label-mention-ngram: the serinet-e2: trigger-arg-path: interacts >nsubj Familyt3e2: ents2Label-mention-ngram: and threonine proteint+e2: ents2Label-mention-ngram: and threoninet'e2: args2Role-mention-ngram: the serinet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: and translocates thet1e2: args2Role-mention-ngram: serine and threoninetAe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] themetde1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='translocate'] >nsubj [lemma='ra'] Familytre2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themetje1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='translocate'] >nsubj [lemma='ra'] theme:Familyt2e2: args2Role-mention-ngram: with and translocatest-e2: args2Role-mention-ngram: translocates thet.e2: args2Role-mention-ngram: threonine proteint(e2: ents2Label-mention-ngram: serine andtye2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_productt)e2: args2Role-mention-ngram: kinase THEMEte2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: serine and threoninet)e2: args2Role-mention-ngram: translocatest6e2: ents2Label-mention-ngram: threonine protein kinasetRe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] themetSe1: trigger-arg-path: bound >ccomp [lemma='translocate'] >nsubj [lemma='ra'] Familyt'e2: args2Role-mention-ngram: serine andt$e2: ents2Label-mention-ngram: serinetUshortest-path: ccomp [lemma='translocate'] >nsubj [lemma='ra']tWe2: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet*e2: ents2Label-mention-ngram: plexin-As bytme1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controllertwe1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] Gene_or_gene_productt&e1: args2Role-mention-ngram: signalingtce2: trigger-arg-path: phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controllert:e2: ents2Label-mention-ngram: nonreceptor tyrosine kinasest%e2: ents2Label-mention-ngram: kinasest6e1: ents2Label-mention-ngram: plexin-As by nonreceptort0e1: ents2Label-mention-ngram: signaling involvest,e2: ents2Label-mention-ngram: by nonreceptort:e1: ents2Label-mention-ngram: phosphorylation of plexin-Astce1: trigger-arg-path: involves >nsubj [lemma='signaling'] >nn [lemma='sema3a'] Gene_or_gene_producttqe2: trigger-arg-path: Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] Gene_or_gene_producttne1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by Gene_or_gene_producttBe2: trigger-arg-path: phosphorylation >prep_of >prep_by controllert)e2: ents2Label-mention-ngram: nonreceptort.e1: ents2Label-mention-ngram: tyrosine kinasest'e1: ents2Label-mention-ngram: signalingt5e1: ents2Label-mention-ngram: by nonreceptor tyrosinetme2: trigger-arg-path: phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controllert_shortest-path: dobj [lemma='phosphorylation']t2e1: ents2Label-mention-ngram: nonreceptor tyrosinet?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: plexin-As by nonreceptorte1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: tyrosine kinases SHAREDtVe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by controllertYe1: trigger-arg-path: involves >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controllert1e1: args2Role-mention-ngram: CONTROLLER signalingt0e1: ents2Label-mention-ngram: kinases SHARED andt-e2: ents2Label-mention-ngram: of plexin-As bytWe2: trigger-arg-path: phosphorylation >prep_of >prep_by controller:Gene_or_gene_producttFe2: trigger-arg-path: Positive_regulation >prep_of >prep_by controllertre2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt)e1: ents2Label-mention-ngram: nonreceptort?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: kinasestwe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controllertne1: trigger-arg-path: involves >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controller:Gene_or_gene_producttge2: trigger-arg-path: Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controllertde1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controller:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controllert*e1: ents2Label-mention-ngram: of plexin-Ast?e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controller:Gene_or_gene_productt:e1: args2Role-mention-ngram: CONTROLLER signaling involvest}e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: of plexin-Ast?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controllert:e2: ents2Label-mention-ngram: phosphorylation of plexin-Astke2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: by nonreceptor tyrosinet0e2: ents2Label-mention-ngram: kinases SHARED andtxe2: trigger-arg-path: phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: plexin-Astprep_of [lemma='plexin-as'] >prep_by [lemma='fe'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: tyrosine kinasestPe2: trigger-arg-path: Positive_regulation >prep_of >prep_by Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: by nonreceptort[e2: trigger-arg-path: Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: kinases SHAREDtTe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by controllertEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT signaling involvest-e1: ents2Label-mention-ngram: of plexin-As bytye1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controller:Gene_or_gene_productt`e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by controllertte1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='signaling'] >nn [lemma='sema3a'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='sema3a'] controllert:e1: args2Role-mention-ngram: signaling involves CONTROLLEDt@e1: ents2Label-mention-ngram: signaling involves phosphorylationt/e1: args2Role-mention-ngram: signaling involveste2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='plexin-as'] >prep_by [lemma='fe'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: kinases SHAREDtLe2: trigger-arg-path: phosphorylation >prep_of >prep_by Gene_or_gene_productt'e1: ents2Label-mention-ngram: plexin-Ast*e1: ents2Label-mention-ngram: plexin-As bytie2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: tyrosine kinases SHAREDt2e2: ents2Label-mention-ngram: nonreceptor tyrosinetshortest-path: prep_tot9e1: trigger-arg-path: binds >prep_to [lemma='grb2'] themet=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT then bindst\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='fak'] theme:Gene_or_gene_producttne2: trigger-arg-path: Binding prep_to [lemma='grb2'] themetNe1: trigger-arg-path: binds >prep_to [lemma='grb2'] theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='SOS'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='grb2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding >nsubj [lemma='fak'] theme:Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding >nn [lemma='SOS'] theme:Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding prep_to [lemma='grb2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex prep_to [lemma='grb2'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='grb2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='SOS'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='fak'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex prep_to Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='grb2'] Gene_or_gene_productt5e2: trigger-arg-path: complex >nn [lemma='SOS'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='fak'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='fak'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: then binds totVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] Gene_or_gene_productt=e2: trigger-arg-path: complex prep_to themet}e2: trigger-arg-path: Binding prep_to [lemma='grb2'] Gene_or_gene_producttEe2: trigger-arg-path: complex:Binding prep_to themetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='grb2'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to themet=e2: trigger-arg-path: Binding prep_to themetGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] themet}e2: trigger-arg-path: complex prep_to [lemma='grb2'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex prep_to themetVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='fak'] Gene_or_gene_producttLe2: trigger-arg-path: Binding prep_to Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='fak'] themet?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='grb2'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='grb2'] themet6e1: trigger-arg-path: binds >nsubj [lemma='fak'] themetMtrigger-to-trigger-path: e1:binds:Binding >conj_and >nsubj e2:complex:Bindingtprep_to [lemma='grb2']tKe1: trigger-arg-path: binds >nsubj [lemma='fak'] theme:Gene_or_gene_producttne2: trigger-arg-path: complex prep_to [lemma='grb2'] themetEe1: trigger-arg-path: binds >nsubj [lemma='fak'] Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_to [lemma='grb2'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='fak'] Gene_or_gene_producttrtrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='activate'] >nsubj [lemma='complex'] e2:complex:BindingtRe2: trigger-arg-path: Binding prep_to theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex prep_to theme:Gene_or_gene_producttTe2: trigger-arg-path: complex:Binding prep_to Gene_or_gene_productt(e1: ents2Label-mention-ngram: then bindst?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='grb2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='grb2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] theme:Gene_or_gene_producttZe2: trigger-arg-path: complex:Binding prep_to theme:Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >prep_to [lemma='grb2'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='grb2'] themetVe1: trigger-arg-path: binds:Binding >prep_to [lemma='grb2'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='grb2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex prep_to [lemma='grb2'] themet-e1: args2Role-mention-ngram: THEME then bindst?e2: trigger-arg-path: complex:Binding prep_to [lemma='grb2'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: then binds totae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='grb2'] Gene_or_gene_productt'e1: args2Role-mention-ngram: then bindst?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='grb2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex prep_to [lemma='grb2'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='grb2'] Gene_or_gene_producttMe1: trigger-arg-path: binds:Binding >nsubj [lemma='fak'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='grb2'] Gene_or_gene_productt?e2: trigger-arg-path: complex prep_to [lemma='grb2'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: THEME thentDe2: trigger-arg-path: complex >nn [lemma='SOS'] Gene_or_gene_producttRe2: trigger-arg-path: complex prep_to theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='SOS'] themet\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='SOS'] theme:Gene_or_gene_producttve2: trigger-arg-path: complex:Binding prep_to [lemma='grb2'] themetJe2: trigger-arg-path: Binding >nn [lemma='SOS'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='SOS'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='SOS'] themet8e1: trigger-arg-path: Binding >nsubj [lemma='fak'] themetGe1: trigger-arg-path: Binding >nsubj [lemma='fak'] Gene_or_gene_productt!interceding-tokens-full-span: andt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='fak'] themetDe2: trigger-arg-path: Binding >nn [lemma='SOS'] Gene_or_gene_producttLe2: trigger-arg-path: complex prep_to Gene_or_gene_productte2: THEME: 3tbe2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by controller:Gene_or_gene_producttme1: trigger-arg-path: blocked >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: K120 CONTROLLEDtZshortest-path: dobj [lemma='acetylation']tde2: trigger-arg-path: acetylation:Positive_regulation prep_by controller:Gene_or_gene_productt:e1: args2Role-mention-ngram: CONTROLLER expression blockedt.e1: ents2Label-mention-ngram: K120 acetylationt,e1: ents2Label-mention-ngram: acetylation oft[e2: trigger-arg-path: acetylation prep_by [lemma='tip60'] controllert?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] controllertce2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] controllertEe2: trigger-arg-path: acetylation prep_by Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt\e1: trigger-arg-path: blocked:Negative_regulation >nsubj >nn controller:Gene_or_gene_producttIe1: trigger-arg-path: Negative_regulation >nsubj >nn Gene_or_gene_producttde1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controllert`trigger-to-trigger-path: e1:blocked:Negative_regulation >dobj e2:acetylation:Positive_regulationt1e1: ents2Label-mention-ngram: K120 acetylation oft)e1: args2Role-mention-ngram: blocked K120tae2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by controllertHe1: trigger-arg-path: blocked >nsubj >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controller:Gene_or_gene_producttOe2: trigger-arg-path: acetylation:Positive_regulation prep_by controllertne1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT expressiontpe2: trigger-arg-path: acetylation prep_by [lemma='tip60'] controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by Gene_or_gene_producttoe2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] controllert!e1: args2Role-mention-ngram: K120tke2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER expressiontwe2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] Gene_or_gene_productt;e2: trigger-arg-path: acetylation prep_by controllertxe2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_producttEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT expression blockedtre1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >nn [lemma='uhrf1'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=block >nsubj >nn controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: expression blocked K120tye1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controller:Gene_or_gene_productt=e1: trigger-arg-path: blocked >nsubj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: expression blockedt3e1: ents2Label-mention-ngram: acetylation of SHAREDtMe2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by controllert?e2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controller:Gene_or_gene_producttPe2: trigger-arg-path: acetylation prep_by controller:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controller:Gene_or_gene_producttTe1: trigger-arg-path: Negative_regulation >nsubj >nn controller:Gene_or_gene_productt3e1: trigger-arg-path: blocked >nsubj >nn controllertve2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by controller:Gene_or_gene_producttee2: trigger-arg-path: acetylation prep_by [lemma='tip60'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=block >nsubj >nn controllertme2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] controllert*e1: ents2Label-mention-ngram: blocked K120tbe1: trigger-arg-path: blocked >nsubj [lemma='expression'] >nn [lemma='uhrf1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: expression blockedt"e1: ents2Label-mention-ngram: K120tGe1: trigger-arg-path: blocked:Negative_regulation >nsubj >nn controllertvtrigger-to-trigger-path: e1:blocked:Negative_regulation >dobj [lemma='acetylation'] e2:acetylation:Positive_regulationtle1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controllert4e1: args2Role-mention-ngram: blocked K120 CONTROLLEDtye2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: blocked K120 acetylationtMe1: trigger-arg-path: lemmatizedTrigger=block >nsubj >nn Gene_or_gene_producttQe1: trigger-arg-path: blocked:Negative_regulation >nsubj >nn Gene_or_gene_producttve1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] Gene_or_gene_producttXe1: trigger-arg-path: blocked >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controllertWe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >nn controllertae1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj >nn Gene_or_gene_producttYe2: trigger-arg-path: acetylation:Positive_regulation prep_by Gene_or_gene_producttme2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: expression blocked K120the1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controllert|e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >nn [lemma='uhrf1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_productt&interceding-tokens-full-span: and thatt2e2: ents2Label-mention-ngram: inhibition of SHAREDt/e2: ents2Label-mention-ngram: binding to SHAREDt=e1-label: Negative_regulation + e2-label: Negative_regulationt*e1: ents2Label-mention-ngram: of SHARED tot7e1: args2Role-mention-ngram: CONTROLLER inhibited Shoc2t@e2: trigger-arg-path: Negative_regulation >nsubj Simple_chemicaltce2: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicaltFe2: trigger-arg-path: suppressed:Negative_regulation >nsubj controllert[e1: trigger-arg-path: inhibited >nsubj [lemma='calmodulin'] controller:Gene_or_gene_producttXe2: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicaltke1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='calmodulin'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: this SHAREDt0e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL 2+tOe2: trigger-arg-path: suppressed >nsubj [lemma='ca'] controller:Simple_chemicaltZe1: trigger-arg-path: Negative_regulation >nsubj [lemma='calmodulin'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj Simple_chemicaltte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='calmodulin'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: this SHARED inhibitiontGe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj Simple_chemicalt/e2: ents2Label-mention-ngram: of SHARED bindingt1e1: ents2Label-mention-ngram: mediated binding oft.e1: ents2Label-mention-ngram: SHARED to SHAREDt(e2: ents2Label-mention-ngram: suppressedt#e1: ents2Label-mention-ngram: Shoc2tVe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='calmodulin'] controllert,e1: ents2Label-mention-ngram: Shoc2 mediatedt"e1: args2Role-mention-ngram: Shoc2t,e1: args2Role-mention-ngram: inhibited Shoc2tee1: trigger-arg-path: Negative_regulation >nsubj [lemma='calmodulin'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='calmodulin'] controllertBe2: trigger-arg-path: suppressed >nsubj controller:Simple_chemicaltXe2: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] Simple_chemicaltPe1: trigger-arg-path: inhibited >nsubj [lemma='calmodulin'] Gene_or_gene_producttetrigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and e2:suppressed:Negative_regulationt4e1: ents2Label-mention-ngram: SHARED inhibited Shoc2t+e2: ents2Label-mention-ngram: inhibition oftxtrigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and [lemma='suppress'] e2:suppressed:Negative_regulationt'e2: args2Role-mention-ngram: suppressedt4e2: ents2Label-mention-ngram: suppressed this SHAREDte2: trigger: suppressedtVe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj controllert;e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL 2+ suppressedt2e2: ents2Label-mention-ngram: SHARED inhibition oft-e2: ents2Label-mention-ngram: suppressed thist2e2: trigger-arg-path: suppressed >nsubj controllertSe2: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] controllert6e1: ents2Label-mention-ngram: inhibited Shoc2 mediatedtde1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='calmodulin'] Gene_or_gene_producttHe2: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] controllertoe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='calmodulin'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: suppressed thistZe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='calmodulin'] controllert_e2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] controller:Simple_chemicalt.e1: ents2Label-mention-ngram: mediated bindingt5e1: args2Role-mention-ngram: inhibited Shoc2 mediatedthe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] Simple_chemicalt'e1: ents2Label-mention-ngram: SHARED totDe2: trigger-arg-path: suppressed >nsubj [lemma='ca'] Simple_chemicalt`e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='calmodulin'] Gene_or_gene_producttKe2: trigger-arg-path: Negative_regulation >nsubj controller:Simple_chemicalt-e1: ents2Label-mention-ngram: inhibited Shoc2t7e2: trigger-arg-path: suppressed >nsubj Simple_chemicaltRe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controller:Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] Simple_chemicalt,e2: args2Role-mention-ngram: this CONTROLLEDt/e2: ents2Label-mention-ngram: SHARED inhibitiont5e2: args2Role-mention-ngram: CONTROLLER 2+ suppressedt+e1: args2Role-mention-ngram: Shoc2 mediatedtce2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] controllertMe2: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] Simple_chemicaltFe1: trigger-arg-path: inhibited >nsubj [lemma='calmodulin'] controllert4e1: ents2Label-mention-ngram: Shoc2 mediated bindingtOe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] controllert/e2: args2Role-mention-ngram: 2+ suppressed thist*e2: args2Role-mention-ngram: 2+ suppressedtPe1: trigger-arg-path: Negative_regulation >nsubj [lemma='calmodulin'] controllert e2: ents2Label-mention-ngram: 2+t.e1: ents2Label-mention-ngram: SHARED inhibitedtfe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj controller:Simple_chemicaltXshortest-path: conj_and [lemma='suppress'] >nsubj [lemma='ca']t*e2: args2Role-mention-ngram: CONTROLLER 2+te1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='calmodulin'] controller:Gene_or_gene_productt?e2: trigger-arg-path: suppressed >nsubj [lemma='ca'] controllertBe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controllert6e1: args2Role-mention-ngram: Shoc2 mediated CONTROLLEDt0e2: ents2Label-mention-ngram: 2+ suppressed thistse2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicaltKe2: trigger-arg-path: suppressed:Negative_regulation >nsubj Simple_chemicaltVe2: trigger-arg-path: suppressed:Negative_regulation >nsubj controller:Simple_chemicalt+e2: ents2Label-mention-ngram: 2+ suppressedt7e2: args2Role-mention-ngram: suppressed this CONTROLLEDte2: args2Role-mention-ngram: 2+t.e2: ents2Label-mention-ngram: called tuberin ,t4e1: args2Role-mention-ngram: can directly CONTROLLEDtTe2: trigger-arg-path: inhibits nsubj [lemma='akt'] controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='akt'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: can directlytJe1: trigger-arg-path: phosphorylate >nsubj controller:Gene_or_gene_productt1interceding-token ngrams: and inactivate tuberoust4e2: args2Role-mention-ngram: which normally inhibitst-e2: ents2Label-mention-ngram: tuberin , whichtTe2: trigger-arg-path: Negative_activation dobj [lemma='mtor'] controlled:Gene_or_gene_productt-e2: ents2Label-mention-ngram: inhibits SHAREDtEe2: trigger-arg-path: Negative_activation nsubj [lemma='akt'] controllert&e2: ents2Label-mention-ngram: ) , alsotme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='mtor'] Gene_or_gene_productt?interceding-tokens-full-span: , as well as indirectly activating it by phosphorylating and inactivate tuberous sclerosis complex 2 (t/interceding-token ngrams: it by phosphorylatingtye2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation conj_and >dobj >rcmod e2:inhibits:Negative_activationt+e2: args2Role-mention-ngram: CONTROLLER ) ,t$e2: args2Role-mention-ngram: tuberint]e2: trigger-arg-path: inhibits:Negative_activation dobj [lemma='mtor'] Gene_or_gene_producttinterceding-token ngrams: 2 (tinterceding-token ngrams: 2t#e2: args2Role-mention-ngram: , alsotSe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj Gene_or_gene_productt(interceding-token ngrams: and inactivatetae1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: called tuberint$interceding-token ngrams: inactivatetSe2: trigger-arg-path: Negative_activation >dobj [lemma='mtor'] Gene_or_gene_producttHe2: trigger-arg-path: inhibits >dobj [lemma='mtor'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: phosphorylatet-e2: args2Role-mention-ngram: called tuberin ,t!interceding-token ngrams: as wellt*e1: ents2Label-mention-ngram: and activatetle1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='akt'] controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: ) ,tie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='akt'] controllertde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj controller:Gene_or_gene_producttinterceding-token ngrams: wellt$interceding-token ngrams: activatingt7interceding-token ngrams: inactivate tuberous sclerosist2interceding-token ngrams: indirectly activating itt)interceding-token ngrams: phosphorylatingt8e1: ents2Label-mention-ngram: phosphorylate and activatetJe2: trigger-arg-path: Negative_activation dobj [lemma='mtor'] controlledt5e2: ents2Label-mention-ngram: which normally inhibitstSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productt-e2: args2Role-mention-ngram: , which normallytEe2: trigger-arg-path: inhibits dobj [lemma='mtor'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj [lemma='akt'] Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='tsc2']t.e2: args2Role-mention-ngram: normally inhibitstXe1: trigger-arg-path: phosphorylate >nsubj [lemma='akt'] controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: normallyt+e2: args2Role-mention-ngram: called tuberint+e2: args2Role-mention-ngram: which normallytxe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='mtor'] controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: which normallytMe1: trigger-arg-path: phosphorylate >nsubj [lemma='akt'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: can directly phosphorylatetPe2: trigger-arg-path: Negative_activation e2: trigger-arg-path: inhibits >dobj [lemma='mtor'] controlledtIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='akt'] controllertSe2: trigger-arg-path: inhibits >dobj [lemma='mtor'] controlled:Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylate:Positive_regulation >conj_and [lemma='inactivate'] >dobj [lemma='tsc2'] >rcmod [lemma='inhibit'] e2:inhibits:Negative_activationt)e2: ents2Label-mention-ngram: also calledt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='akt'] controller:Gene_or_gene_productt4interceding-token ngrams: tuberous sclerosis complext;e2: trigger-arg-path: Negative_activation dobj [lemma='mtor'] controlledt5e1: trigger-arg-path: phosphorylate >nsubj controllert-interceding-token ngrams: phosphorylating andt4e1: args2Role-mention-ngram: CONTROLLER can directlyt?e2: trigger-arg-path: inhibits nsubj [lemma='akt'] controllert&e2: ents2Label-mention-ngram: normallyt?e1: trigger-arg-path: phosphorylate >nsubj Gene_or_gene_productt#e2: args2Role-mention-ngram: calledtUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj [lemma='akt'] controllertse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productt'interceding-token ngrams: activating itt+e2: ents2Label-mention-ngram: , also calledtIe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj controllert6e2: ents2Label-mention-ngram: normally inhibits SHAREDt%interceding-token ngrams: complex 2 (t\e2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='mtor'] Gene_or_gene_productt#interceding-token ngrams: complex 2t'interceding-token ngrams: as indirectlytIe2: trigger-arg-path: Negative_activation >dobj [lemma='mtor'] controlledt^e2: trigger-arg-path: Negative_activation >dobj [lemma='mtor'] controlled:Gene_or_gene_productt-interceding-token ngrams: sclerosis complex 2t!interceding-token ngrams: well ast)e2: args2Role-mention-ngram: CONTROLLER )tDe2: trigger-arg-path: inhibits:Negative_activation dobj [lemma='mtor'] controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >dobj PhosphorylationtHe2: trigger-arg-path: inhibits:Positive_regulation >dobj Phosphorylationtbe2: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt*e1: args2Role-mention-ngram: also inhibitstAe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn Familyt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced Rast~e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt]e2: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] controlledtEe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Phosphorylationthe2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familyt:e1: trigger-arg-path: induced >ccomp >dobj Phosphorylationt5e1: args2Role-mention-ngram: inhibition also inhibitstFe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >dobj controlledtae1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ft'] controllertOe2: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn controller:FamilytWe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] Gene_or_gene_producttCe2: trigger-arg-path: inhibits:Positive_regulation >dobj controlledt*e2: args2Role-mention-ngram: also inhibitstZe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ft'] Gene_or_gene_producttRe2: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familytwe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationtqe1: trigger-arg-path: induced >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationtke1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ft'] Gene_or_gene_productt,e1: args2Role-mention-ngram: inhibition alsot5e1: args2Role-mention-ngram: also inhibits CONTROLLEDtTe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj controlledt3e1: args2Role-mention-ngram: induced Ras inhibitiont-e2: ents2Label-mention-ngram: inhibition alsotce2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] FamilytTe1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationt)e1: ents2Label-mention-ngram: induced RastNe1: trigger-arg-path: induced:Negative_regulation >ccomp >dobj Phosphorylationt4e1: ents2Label-mention-ngram: induced Ras inhibitiont_e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >dobj Phosphorylationt6e2: ents2Label-mention-ngram: inhibition also inhibitstde2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj controlled:Phosphorylationt e1: args2Role-mention-ngram: Rastje2: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllert0e1: args2Role-mention-ngram: Ras inhibition alsotPe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:Phosphorylationt/e2: ents2Label-mention-ngram: FAMILY inhibitiont4e2: ents2Label-mention-ngram: FAMILY inhibition alsotme1: trigger-arg-path: Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlledtMe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] controllert+e2: ents2Label-mention-ngram: also inhibitst+e1: args2Role-mention-ngram: Ras inhibitiont]e2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familyt4e2: trigger-arg-path: inhibits >nsubj >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] Phosphorylationtae1: trigger-arg-path: induced >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlledtze1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] Phosphorylationt`e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn controller:FamilytCe1: trigger-arg-path: induced:Negative_regulation >nsubj controllertZe1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >dobj controlledtVe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >dobj controlled:PhosphorylationtIe1: trigger-arg-path: induced:Negative_regulation >ccomp >dobj controlledtQe1: trigger-arg-path: Negative_regulation >ccomp >dobj controlled:Phosphorylationt5e2: args2Role-mention-ngram: also inhibits CONTROLLEDtYe2: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] controlled:PhosphorylationtLe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Familyt2e2: ents2Label-mention-ngram: also inhibits SHAREDtDe1: trigger-arg-path: induced >nsubj controller:Gene_or_gene_producttme2: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtje1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >dobj controlled:Phosphorylationt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducedtue1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlledtAe1: trigger-arg-path: Negative_regulation >ccomp >dobj controlledtFe1: trigger-arg-path: induced >nsubj [lemma='ft'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] Phosphorylationt,e2: args2Role-mention-ngram: inhibition alsotfe2: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] FamilytHe2: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn controllertve1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: induced Rast-e1: ents2Label-mention-ngram: inhibition alsot5e2: args2Role-mention-ngram: inhibition also inhibitstae2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllert^trigger-to-trigger-path: e1:induced:Negative_regulation >ccomp e2:inhibits:Positive_regulationtPe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ft'] controllertfe1: trigger-arg-path: induced >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] PhosphorylationtSe2: trigger-arg-path: inhibits:Positive_regulation >dobj controlled:Phosphorylationtge2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllertZe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] controlledtre1: trigger-arg-path: Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] Phosphorylationtnsubj [lemma='ft'] controllert]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_producttlshortest-path: ccomp [lemma='inhibit'] >nsubj [lemma='inhibition'] >nn [lemma='ra']tqe2: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familyt(e1: ents2Label-mention-ngram: inhibitiontYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn controllert+e1: ents2Label-mention-ngram: also inhibitstMe1: trigger-arg-path: induced:Negative_regulation >nsubj Gene_or_gene_productt?e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationtre1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlledtIe2: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn FamilytEe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controllertDe2: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn FamilytEe1: trigger-arg-path: induced >ccomp >dobj controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familytee1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: Ras inhibitiont;e2: trigger-arg-path: Positive_regulation >nsubj >nn Familyt!e1: ents2Label-mention-ngram: Rast5e1: trigger-arg-path: induced >ccomp >dobj controlledtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj [lemma='phosphorylation'] controlledt{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllert2e2: args2Role-mention-ngram: CONTROLLER inhibitiont2e1: ents2Label-mention-ngram: also inhibits SHAREDt'e1: args2Role-mention-ngram: inhibitiont?e2: trigger-arg-path: inhibits >dobj controlled:Phosphorylationtne2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familyt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlledtRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ft'] Gene_or_gene_productt}e1: trigger-arg-path: Negative_regulation >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] controlled:PhosphorylationtVe2: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllertse2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt3e1: args2Role-mention-ngram: CONTROLLER induced RastXe1: trigger-arg-path: induced:Negative_regulation >nsubj controller:Gene_or_gene_productt0e2: trigger-arg-path: inhibits >nsubj >nn FamilytYe1: trigger-arg-path: induced:Negative_regulation >ccomp >dobj controlled:Phosphorylationt4e2: trigger-arg-path: inhibits >dobj Phosphorylationt;e2: trigger-arg-path: inhibits >nsubj >nn controller:FamilytFe1: trigger-arg-path: Negative_regulation >ccomp >dobj PhosphorylationtQe1: trigger-arg-path: induced >nsubj [lemma='ft'] controller:Gene_or_gene_producttptrigger-to-trigger-path: e1:induced:Negative_regulation >ccomp [lemma='inhibit'] e2:inhibits:Positive_regulationt=e2: ents2Label-mention-ngram: inhibits SHARED phosphorylationtje2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phosphorylation'] controlled:PhosphorylationtFe2: trigger-arg-path: Positive_regulation >nsubj >nn controller:Familyt9e1: trigger-arg-path: induced >nsubj Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] controller:Gene_or_gene_producttNe2: trigger-arg-path: inhibits >dobj [lemma='phosphorylation'] PhosphorylationtHe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ft'] controllertwe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] >dobj [lemma='phosphorylation'] PhosphorylationtYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj Phosphorylationt]e2: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familyt^e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj Gene_or_gene_productt7e2: args2Role-mention-ngram: CONTROLLER inhibition alsotVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to >nn theme:Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding prep_to [lemma='site'] >nn [lemma='sp1'] themetHe2: trigger-arg-path: lemmatizedTrigger=bind prep_to >nn Gene_or_gene_productt7e2: trigger-arg-path: binds prep_withtfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to >nn Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME and Sp1tse2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='site'] >nn [lemma='sp1'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to >nn themetIe2: trigger-arg-path: Binding prep_to >nn theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind prep_to [lemma='site'] >nn [lemma='sp1'] Gene_or_gene_producttMe2: trigger-arg-path: Binding >prep_to [lemma='site'] >nn [lemma='sp1'] themet6e2: trigger-arg-path: binds:Binding >prep_to >nn themet+e2: args2Role-mention-ngram: which binds totbe2: trigger-arg-path: binds:Binding >prep_to [lemma='site'] >nn [lemma='sp1'] Gene_or_gene_productt)e2: args2Role-mention-ngram: binds to thet.e2: trigger-arg-path: binds >prep_to >nn themet?e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_with [lemma='hdac1'] >rcmod [lemma='bind'] e2:binds:Bindingt*e2: args2Role-mention-ngram: , which bindst!e2: ents2Label-mention-ngram: Sp1t8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT formst'e2: ents2Label-mention-ngram: and Sp1 ,t&e2: args2Role-mention-ngram: and Sp1 ,tatrigger-to-trigger-path: e1:forms a complex:Binding prep_with >rcmod e2:binds:Bindingt?shortest-path: prep_with [lemma='hdac1']t%e2: ents2Label-mention-ngram: and Sp1tXe2: trigger-arg-path: lemmatizedTrigger=bind prep_to [lemma='site'] >nn [lemma='sp1'] themetKe2: trigger-arg-path: binds:Binding >prep_to >nn theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: to the THEMEtSe2: trigger-arg-path: binds:Binding >prep_to [lemma='site'] >nn [lemma='sp1'] themetqe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='site'] >nn [lemma='sp1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: lemmatizedTrigger=bind prep_to >nn Gene_or_gene_productt)e2: ents2Label-mention-ngram: Sp1 , whicht0e2: trigger-arg-path: Binding >prep_to >nn themet e2: args2Role-mention-ngram: Sp1tOe2: trigger-arg-path: binds:Binding prep_to >nn Gene_or_gene_productt=e2: trigger-arg-path: binds >prep_to >nn Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='site'] >nn [lemma='sp1'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binds prep_to >nn theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >prep_to >nn theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: which bindst:e2: trigger-arg-path: Binding prep_to [lemma='site'] >nn [lemma='sp1'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='site'] >nn [lemma='sp1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: Sp1 , whichtEe2: trigger-arg-path: binds:Binding prep_to [lemma='site'] >nn [lemma='sp1'] theme:Gene_or_gene_productt9e2: ents2Label-mention-ngram: to the GENE_OR_GENE_PRODUCTtPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='site'] >nn [lemma='sp1'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: Sp1 ,t1e1: ents2Label-mention-ngram: complex with SHAREDtbe2: trigger-arg-path: Binding >prep_to [lemma='site'] >nn [lemma='sp1'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: Sp1 ,t,e2: ents2Label-mention-ngram: SHARED and Sp1tde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='site'] >nn [lemma='sp1'] themetOe2: trigger-arg-path: Binding nn [lemma='cdc25'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] Gene_or_gene_productthe1: trigger-arg-path: binding:Binding nn [lemma='cdc25'] Gene_or_gene_productt`e1: trigger-arg-path: Binding nn [lemma='cdc25'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] theme:Gene_or_gene_producttYe1: trigger-arg-path: binding:Binding nn [lemma='cdc25'] themetje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding nn [lemma='cdc25'] themet\e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] Gene_or_gene_producttfe1: trigger-arg-path: Binding nn [lemma='cdc25'] theme:Gene_or_gene_productt;e2: trigger-arg-path: interaction >nn [lemma='cdc25'] themetce1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] themetke1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] themetnn [lemma='cdc25']tLe2: trigger-arg-path: Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] themetJe2: trigger-arg-path: interaction >nn [lemma='cdc25'] Gene_or_gene_producttPe2: trigger-arg-path: interaction >nn [lemma='cdc25'] theme:Gene_or_gene_producttfe1: trigger-arg-path: binding nn [lemma='cdc25'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='cdc25'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] themet7e2: trigger-arg-path: Binding >nn [lemma='cdc25'] themetCe2: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] themet`e1: trigger-arg-path: binding nn [lemma='cdc25'] Gene_or_gene_producttRe2: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] Gene_or_gene_producttXe2: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttQe1: trigger-arg-path: binding nn [lemma='cdc25'] themet"interceding-token ngrams: recruitst-e1: ents2Label-mention-ngram: recruits SHAREDt:e1: args2Role-mention-ngram: CONTROLLER phosphorylates andt+shortest-path: vmod >xcomp >prep_tot?e2: trigger-arg-path: Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >dobj [lemma='kinase'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] theme:Gene_or_gene_productt]e1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='pdk1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: recruits SHARED totUe1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj controllert'interceding-token ngrams: , bringing itt?e2: trigger-arg-path: bound >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep >vmod >xcomp >prep_to themet,interceding-token ngrams: complex , bringingt+interceding-token ngrams: also recruits thet$interceding-token ngrams: , bringingt*e1: ents2Label-mention-ngram: and recruitstMe2: trigger-arg-path: bound >dobj [lemma='kinase'] theme:Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] themet@e2: trigger-arg-path: bound:Binding >dobj [lemma='kinase'] themetyshortest-path: vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta']tOe2: trigger-arg-path: bound:Binding >dobj [lemma='kinase'] Gene_or_gene_productt.interceding-token ngrams: recruits the CARMA1-tXe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='kinase'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] themetje1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj controller:Gene_or_gene_producttGe2: trigger-arg-path: bound >dobj [lemma='kinase'] Gene_or_gene_producttDe1: trigger-arg-path: recruits:Positive_regulation >nsubj controllertNe1: trigger-arg-path: recruits:Positive_regulation >nsubj Gene_or_gene_producttOe2: trigger-arg-path: Binding >dobj [lemma='kinase'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj Gene_or_gene_producttAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylatestKe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj Gene_or_gene_productt"interceding-token ngrams: bringingt+e1: ents2Label-mention-ngram: to the plasmat1e1: ents2Label-mention-ngram: and recruits SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] theme:Gene_or_gene_productt]trigger-to-trigger-path: e1:recruits:Positive_regulation nsubj Gene_or_gene_productt?e2: trigger-arg-path: Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] themetIe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='kinase'] themet%interceding-token ngrams: it proximalt(e1: ents2Label-mention-ngram: the plasmat?e2: trigger-arg-path: lemmatizedTrigger=bind >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] Gene_or_gene_productt*interceding-token ngrams: -MALT1 complex ,t:e1: args2Role-mention-ngram: phosphorylates and CONTROLLEDt?e2: trigger-arg-path: bound >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: membranet&e1: ents2Label-mention-ngram: recruitst!interceding-token ngrams: CARMA1-t(interceding-token ngrams: -MALT1 complext^e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='kinase'] theme:Gene_or_gene_producttQe2: trigger-arg-path: bound >dep >vmod >xcomp >prep_to theme:Gene_or_gene_producttEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates andt"interceding-token ngrams: proximalt+interceding-token ngrams: and also recruitst)interceding-token ngrams: proximal to thetfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='kinase'] theme:Gene_or_gene_productt(interceding-token ngrams: it proximal totSe2: trigger-arg-path: bound:Binding >dep >vmod >xcomp >prep_to Gene_or_gene_productt0e1: trigger-arg-path: recruits >nsubj controllertVe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj controller:Gene_or_gene_productt&interceding-token ngrams: recruits thetye1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='pdk1'] controller:Gene_or_gene_productt+interceding-token ngrams: the CARMA1- Bcl10t'interceding-token ngrams: CARMA1- Bcl10tDe2: trigger-arg-path: bound:Binding >dep >vmod >xcomp >prep_to themetNtrigger-to-trigger-path: e1:recruits:Positive_regulation dobj [lemma='kinase'] themet?e2: trigger-arg-path: bound >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] themet1e1: ents2Label-mention-ngram: the plasma membranetKe2: trigger-arg-path: bound >dep >vmod >xcomp >prep_to Gene_or_gene_productt+e1: ents2Label-mention-ngram: SHARED to thet&interceding-token ngrams: Bcl10 -MALT1tdep >vmod >xcomp >prep_to themetTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pdk1'] Gene_or_gene_producttYe2: trigger-arg-path: bound:Binding >dep >vmod >xcomp >prep_to theme:Gene_or_gene_productte1: trigger: recruitst:e2: trigger-arg-path: Binding >dobj [lemma='kinase'] themet?e2: ents2Label-mention-ngram: SHARED bound GENE_OR_GENE_PRODUCTtEe1: trigger-arg-path: recruits >nsubj controller:Gene_or_gene_producttSe2: trigger-arg-path: Binding >dep >vmod >xcomp >prep_to theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='kinase'] Gene_or_gene_producttUe2: trigger-arg-path: bound:Binding >dobj [lemma='kinase'] theme:Gene_or_gene_productt.interceding-token ngrams: Bcl10 -MALT1 complextde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep >vmod >xcomp >prep_to Gene_or_gene_productt%interceding-token ngrams: proximal totSe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='pdk1'] controllertPe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='pdk1'] controllertAe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj controllert.interceding-token ngrams: bringing it proximalt\e2: trigger-arg-path: lemmatizedTrigger=bind >dep >vmod >xcomp >prep_to Gene_or_gene_productt6e1: args2Role-mention-ngram: CONTROLLER phosphorylatest?e2: trigger-arg-path: bound:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='pdk1'] controller:Gene_or_gene_producttninterceding-tokens-full-span: and also recruits the CARMA1- Bcl10 -MALT1 complex , bringing it proximal to thet$e1: ents2Label-mention-ngram: to thetIe1: trigger-arg-path: recruits >nsubj [lemma='pdk1'] Gene_or_gene_productt"interceding-token ngrams: and alsot.interceding-token ngrams: CARMA1- Bcl10 -MALT1t%interceding-token ngrams: bringing itthe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='pdk1'] controller:Gene_or_gene_productt8e2: trigger-arg-path: bound >dobj [lemma='kinase'] themetne1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='pdk1'] Gene_or_gene_producttYe1: trigger-arg-path: recruits:Positive_regulation >nsubj controller:Gene_or_gene_producttTe1: trigger-arg-path: recruits >nsubj [lemma='pdk1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: recruits >nsubj [lemma='pdk1'] controllert9e1: ents2Label-mention-ngram: phosphorylates and recruitste2: THEME: 4t%interceding-token ngrams: the CARMA1-t-e1: ents2Label-mention-ngram: plasma membranetMe2: trigger-arg-path: lemmatizedTrigger=bind >dep >vmod >xcomp >prep_to themetZe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='pdk1'] Gene_or_gene_productt interceding-token ngrams: -MALT1t>e2: trigger-arg-path: Binding >dep >vmod >xcomp >prep_to themetMe2: trigger-arg-path: Binding >dep >vmod >xcomp >prep_to Gene_or_gene_productt$e1: ents2Label-mention-ngram: plasmatJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pdk1'] controllert#interceding-token ngrams: complex ,t?e2: trigger-arg-path: Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] theme:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='pdk1'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind >dep >vmod >xcomp >prep_to theme:Gene_or_gene_producttinterceding-token ngrams: Bcl10t'interceding-token ngrams: also recruitstde1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='pdk1'] controllertje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep >vmod >xcomp >prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind >dep [lemma='phosphorylate'] >vmod [lemma='bring'] >xcomp [lemma='proximal'] >prep_to [lemma='pkctheta'] themet]e1: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='p300'] Gene_or_gene_producttBe2: trigger-arg-path: Binding >prep_between [lemma='parp-1'] themetFe2: trigger-arg-path: interaction >prep_between [lemma='parp-1'] themetre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p50'] theme:Gene_or_gene_productt%interceding-token ngrams: , enhancingt-interceding-tokens-full-span: , enhancing thetBe1: trigger-arg-path: lemmatizedTrigger=acetylation >nn controllertKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='p50'] themetdtrigger-to-trigger-path: e1:acetylation:Positive_regulation vmod >dobj e2:interaction:Bindingt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='parp-1'] themet$shortest-path: vmod >dobjt)interceding-token ngrams: , enhancing thetce2: trigger-arg-path: interaction:Binding >prep_between [lemma='parp-1'] theme:Gene_or_gene_producttWe2: trigger-arg-path: Binding >prep_between [lemma='parp-1'] theme:Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_between [lemma='parp-1'] Gene_or_gene_productt:e1: trigger-arg-path: acetylation >nn Gene_or_gene_producttZe2: trigger-arg-path: interaction:Binding >prep_between [lemma='p50'] Gene_or_gene_producttTe1: trigger-arg-path: acetylation >nn [lemma='p300'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: and CBPt0e1: ents2Label-mention-ngram: CBP acetylation oftge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='parp-1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='p300'] controllertDe1: trigger-arg-path: acetylation:Positive_regulation >nn controllertTe2: trigger-arg-path: Binding >prep_between [lemma='p50'] theme:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='parp-1'] Gene_or_gene_producttSe1: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='p300'] controllertIe1: trigger-arg-path: acetylation >nn [lemma='p300'] Gene_or_gene_producttNe1: trigger-arg-path: acetylation:Positive_regulation >nn Gene_or_gene_productte1: trigger: acetylationtze1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='p300'] controller:Gene_or_gene_productt?e1: trigger-arg-path: acetylation >nn [lemma='p300'] controllertde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p50'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='parp-1'] theme:Gene_or_gene_producttEe1: trigger-arg-path: acetylation >nn controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='parp-1'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: CBPtNe2: trigger-arg-path: Binding >prep_between [lemma='p50'] Gene_or_gene_productttshortest-path: vmod [lemma='enhance'] >dobj [lemma='interaction']t%e1: ents2Label-mention-ngram: and CBPt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and CBPtLe1: trigger-arg-path: lemmatizedTrigger=acetylation >nn Gene_or_gene_productt]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='parp-1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=acetylation >nn controller:Gene_or_gene_producttYe1: trigger-arg-path: acetylation:Positive_regulation >nn controller:Gene_or_gene_producttNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='parp-1'] themetXe2: trigger-arg-path: interaction >prep_between [lemma='p50'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:acetylation:Positive_regulation vmod [lemma='enhance'] >dobj [lemma='interaction'] e2:interaction:Bindingtfe1: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='p300'] controller:Gene_or_gene_producttRe2: trigger-arg-path: interaction >prep_between [lemma='p50'] Gene_or_gene_productt[e2: trigger-arg-path: interaction >prep_between [lemma='parp-1'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: CBP CONTROLLEDtQe1: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='p300'] controllert[e1: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='p300'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: CBP acetylationt`e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn Gene_or_gene_productt1e1: ents2Label-mention-ngram: and CBP acetylationtGe1: trigger-arg-path: Positive_regulation >nn [lemma='p300'] controllertQe1: trigger-arg-path: Positive_regulation >nn [lemma='p300'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn controller:Gene_or_gene_productt'interceding-token ngrams: enhancing thetCe2: trigger-arg-path: interaction >prep_between [lemma='p50'] themet`e2: trigger-arg-path: interaction:Binding >prep_between [lemma='p50'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p50'] themetXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='parp-1'] themetUe2: trigger-arg-path: interaction >prep_between [lemma='parp-1'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p50'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn controllert?e2: trigger-arg-path: Binding >prep_between [lemma='p50'] themethe1: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='p300'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: and CBP CONTROLLEDt]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p50'] themet\e1: trigger-arg-path: Positive_regulation >nn [lemma='p300'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER and CBPtle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p50'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='p300'] Gene_or_gene_productt0e1: trigger-arg-path: acetylation >nn controllert!e1: ents2Label-mention-ngram: CBPt'e2: ents2Label-mention-ngram: structuret&e1: args2Role-mention-ngram: structuret&e2: args2Role-mention-ngram: structuretGe1: trigger-arg-path: Binding >nsubj >prep_of >nn theme:Simple_chemicalt$e2: args2Role-mention-ngram: black )tGe1: trigger-arg-path: bound:Binding >nsubj >prep_of >nn Simple_chemicalt e2: args2Role-mention-ngram: PDBt!e2: args2Role-mention-ngram: A59Gt(e2: args2Role-mention-ngram: black ) andt"e2: args2Role-mention-ngram: blackt(e1: ents2Label-mention-ngram: ( PDB 1LF0t4e2: args2Role-mention-ngram: conformers with respecttEe1: trigger-arg-path: bound >nsubj >prep_of >nn theme:Simple_chemicalt%e1: args2Role-mention-ngram: PDB 1LF0t'e2: args2Role-mention-ngram: PDB 1LF0 ,t)e1: ents2Label-mention-ngram: black ) andtwe2: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt-e1: ents2Label-mention-ngram: conformers withtve2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet'e2: ents2Label-mention-ngram: , black )t(e2: args2Role-mention-ngram: structure (t&e1: ents2Label-mention-ngram: PDB 1LF0t&e2: args2Role-mention-ngram: , black )t&e2: ents2Label-mention-ngram: PDB 1LF0tXe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn Simple_chemicalt(e2: ents2Label-mention-ngram: respect tot#e2: ents2Label-mention-ngram: blackt)e1: ents2Label-mention-ngram: structure (tFe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn themet&e1: args2Role-mention-ngram: GTP boundt-e2: ents2Label-mention-ngram: GTP bound H-Rast&e2: args2Role-mention-ngram: GTP boundt5e1: ents2Label-mention-ngram: conformers with respectt'e1: args2Role-mention-ngram: H-Ras A59Gt,e1: args2Role-mention-ngram: GTP bound H-Rast?e1: trigger-arg-path: bound >nsubj >prep_of >nn Simple_chemicaltXe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn Simple_chemicalt/e2: ents2Label-mention-ngram: crystal structuretMe1: trigger-arg-path: bound:Binding >nsubj >prep_of >nn theme:Simple_chemicalt"e2: args2Role-mention-ngram: ( PDBtAe1: trigger-arg-path: Binding >nsubj >prep_of >nn Simple_chemicalt,e1: args2Role-mention-ngram: structure ( PDBt'e2: args2Role-mention-ngram: respect totee1: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet0e1: ents2Label-mention-ngram: H-Ras A59G crystalt#e1: ents2Label-mention-ngram: H-Rast(e2: ents2Label-mention-ngram: PDB 1LF0 ,t"e1: args2Role-mention-ngram: H-Rast7e2: trigger-arg-path: Binding >nsubj >prep_of >nn themet3e2: args2Role-mention-ngram: A59G crystal structuret$e1: ents2Label-mention-ngram: 1LF0 ,t)e2: args2Role-mention-ngram: 1LF0 , blackt)e2: ents2Label-mention-ngram: bound H-Rast-e2: ents2Label-mention-ngram: structure ( PDBt!e2: ents2Label-mention-ngram: GTPt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] Gene_or_gene_producttLe2: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: to the GTPtMe2: trigger-arg-path: bound:Binding >nsubj >prep_of >nn theme:Simple_chemicalt5e1: trigger-arg-path: bound >dobj [lemma='GDP'] themet*e1: args2Role-mention-ngram: the GTP boundt$e1: args2Role-mention-ngram: respectt4e1: ents2Label-mention-ngram: A59G crystal structuret#e2: ents2Label-mention-ngram: ( PDBt!e2: args2Role-mention-ngram: 1LF0t(e2: args2Role-mention-ngram: bound H-Rast'e1: ents2Label-mention-ngram: GTP boundt+e2: args2Role-mention-ngram: respect to thet'e2: args2Role-mention-ngram: to the GTPt*e2: args2Role-mention-ngram: the GTP boundt&e2: args2Role-mention-ngram: ) and thet*e1: ents2Label-mention-ngram: A59G crystaltFe1: trigger-arg-path: Binding >dobj [lemma='GDP'] Gene_or_gene_productt(e1: args2Role-mention-ngram: black ) andt%e2: ents2Label-mention-ngram: , blackt,e2: args2Role-mention-ngram: structure ( PDBt2e1: args2Role-mention-ngram: THEME conformers witht'e2: ents2Label-mention-ngram: ) and thetNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] themet5e2: ents2Label-mention-ngram: conformers with respectt1e1: ents2Label-mention-ngram: crystal structure (t%e2: ents2Label-mention-ngram: respecttGe2: trigger-arg-path: Binding >nsubj >prep_of >nn theme:Simple_chemicalt&e1: args2Role-mention-ngram: ) and thet"e2: ents2Label-mention-ngram: A59Gt"e1: ents2Label-mention-ngram: A59Gt,e2: ents2Label-mention-ngram: respect to thetGe2: trigger-arg-path: bound:Binding >nsubj >prep_of >nn Simple_chemicalt*e1: ents2Label-mention-ngram: with respectt&e1: args2Role-mention-ngram: , black )tAe2: trigger-arg-path: Binding >nsubj >prep_of >nn Simple_chemicaltFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] themet*e2: ents2Label-mention-ngram: with respecttqe1: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltqe2: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt"e2: args2Role-mention-ngram: H-Rast*e2: ents2Label-mention-ngram: A59G crystaltLe2: trigger-arg-path: Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: structuretve1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet(e2: ents2Label-mention-ngram: conformerst(e1: args2Role-mention-ngram: structure (t(e1: ents2Label-mention-ngram: respect tot&shortest-path: nsubj >prep_of >nn Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt7e1: trigger-arg-path: Binding >nsubj >prep_of >nn themet.e1: args2Role-mention-ngram: crystal structuret/e1: ents2Label-mention-ngram: SHARED conformerst%e1: ents2Label-mention-ngram: , blackt)e1: args2Role-mention-ngram: 1LF0 , blackt$e1: args2Role-mention-ngram: , blackt-e2: args2Role-mention-ngram: THEME conformerst4e2: ents2Label-mention-ngram: SHARED conformers witht.e1: ents2Label-mention-ngram: bound H-Ras A59Gt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] theme:Gene_or_gene_producttge1: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet'e1: ents2Label-mention-ngram: , black )t'e2: args2Role-mention-ngram: conformerstVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn theme:Simple_chemicalt(e1: ents2Label-mention-ngram: PDB 1LF0 ,t4e1: args2Role-mention-ngram: conformers with respectt%e1: ents2Label-mention-ngram: respecttRe2: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: GTP bound H-Rast}e1: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt,e1: ents2Label-mention-ngram: and the SHAREDt$e2: ents2Label-mention-ngram: 1LF0 ,t#e2: ents2Label-mention-ngram: H-Rast%e2: ents2Label-mention-ngram: crystalt0e2: ents2Label-mention-ngram: H-Ras A59G crystalt)e1: ents2Label-mention-ngram: bound H-Rast#e1: args2Role-mention-ngram: 1LF0 ,tUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: 1LF0t e1: args2Role-mention-ngram: GTPt-e1: ents2Label-mention-ngram: structure ( PDBtge2: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt,e1: args2Role-mention-ngram: with respect totLe1: trigger-arg-path: Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn theme:Simple_chemicaltVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn theme:Simple_chemicalt'e1: args2Role-mention-ngram: respect tot[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: the GTP boundt/e2: args2Role-mention-ngram: H-Ras A59G crystaltNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] themet5e1: trigger-arg-path: bound >nsubj >prep_of >nn themet$e2: args2Role-mention-ngram: respectt(e1: ents2Label-mention-ngram: to the GTPt%e1: ents2Label-mention-ngram: crystalt?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltLe1: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: PDBt'e1: args2Role-mention-ngram: PDB 1LF0 ,t,e2: ents2Label-mention-ngram: and the SHAREDt$e1: args2Role-mention-ngram: crystaltNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn themetUe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] Gene_or_gene_productt)e2: args2Role-mention-ngram: with respectt5e2: trigger-arg-path: bound >dobj [lemma='GDP'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn theme:Simple_chemicaltue1: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltEe2: trigger-arg-path: bound >nsubj >prep_of >nn theme:Simple_chemicaltFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn themet'e1: ents2Label-mention-ngram: ) and thet'e2: args2Role-mention-ngram: H-Ras A59Gt(e2: ents2Label-mention-ngram: ( PDB 1LF0t-e1: ents2Label-mention-ngram: GTP bound H-Rast(e1: ents2Label-mention-ngram: conformerst e2: args2Role-mention-ngram: GTPtJe2: trigger-arg-path: bound >dobj [lemma='GDP'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: A59G crystalt'e1: args2Role-mention-ngram: to the GTPt+e1: args2Role-mention-ngram: respect to thet0e1: args2Role-mention-ngram: crystal structure (t(e1: args2Role-mention-ngram: bound H-Rast"e2: ents2Label-mention-ngram: 1LF0t$e2: args2Role-mention-ngram: , blackt4e2: ents2Label-mention-ngram: A59G crystal structuretFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='GDP'] themet!e2: ents2Label-mention-ngram: PDBt=e1: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] themet-e1: args2Role-mention-ngram: bound H-Ras A59Gt/e2: ents2Label-mention-ngram: SHARED conformerstwe1: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt#e2: args2Role-mention-ngram: 1LF0 ,t%e2: ents2Label-mention-ngram: black )tJe1: trigger-arg-path: bound >dobj [lemma='GDP'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: ( PDB 1LF0t"e1: args2Role-mention-ngram: ) andt=e2: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] themet-e2: ents2Label-mention-ngram: with respect tot?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt!e1: args2Role-mention-ngram: A59Gt1e2: ents2Label-mention-ngram: crystal structure (t-e2: ents2Label-mention-ngram: conformers witht-e1: args2Role-mention-ngram: THEME conformerstNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >nn themetee2: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet'e1: args2Role-mention-ngram: conformerstPe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn Simple_chemicalt,e1: args2Role-mention-ngram: conformers witht7e2: trigger-arg-path: Binding >dobj [lemma='GDP'] themetoe1: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt(e2: ents2Label-mention-ngram: H-Ras A59GtDe1: trigger-arg-path: bound >dobj [lemma='GDP'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED conformers witht?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt$e2: args2Role-mention-ngram: crystaltFe2: trigger-arg-path: Binding >dobj [lemma='GDP'] Gene_or_gene_productt#e1: args2Role-mention-ngram: to thet%e1: ents2Label-mention-ngram: black )t)e2: ents2Label-mention-ngram: black ) andt+e1: ents2Label-mention-ngram: the GTP boundtoe2: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt/e1: ents2Label-mention-ngram: crystal structuret$e1: args2Role-mention-ngram: black )tPe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >nn Simple_chemicalt%e2: ents2Label-mention-ngram: the GTPtme2: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themetRe1: trigger-arg-path: bound:Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: with respect tot)e2: ents2Label-mention-ngram: structure (t#e1: ents2Label-mention-ngram: blackt)e1: args2Role-mention-ngram: with respectt,e2: args2Role-mention-ngram: conformers witht0e2: args2Role-mention-ngram: crystal structure (t5e2: trigger-arg-path: bound >nsubj >prep_of >nn themet"e1: args2Role-mention-ngram: blackt*e1: ents2Label-mention-ngram: 1LF0 , blackt)e1: args2Role-mention-ngram: A59G crystalt e1: args2Role-mention-ngram: PDBt=e2: trigger-arg-path: bound:Binding >nsubj >prep_of >nn themet%e2: args2Role-mention-ngram: PDB 1LF0t!e1: args2Role-mention-ngram: 1LF0twe2: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt*e2: ents2Label-mention-ngram: 1LF0 , blacktme1: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet7e1: trigger-arg-path: Binding >dobj [lemma='GDP'] themet'e2: ents2Label-mention-ngram: GTP boundt.e2: args2Role-mention-ngram: crystal structuret*e2: args2Role-mention-ngram: and the THEMEt=e1: trigger-arg-path: bound:Binding >nsubj >prep_of >nn themet~e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet%e1: ents2Label-mention-ngram: the GTPt?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt}e2: trigger-arg-path: bound:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt!e1: ents2Label-mention-ngram: GTPt$e1: args2Role-mention-ngram: the GTPt-e1: ents2Label-mention-ngram: with respect tot,e1: ents2Label-mention-ngram: respect to thet#e1: ents2Label-mention-ngram: ( PDBt(e1: ents2Label-mention-ngram: H-Ras A59Gt"e1: args2Role-mention-ngram: ( PDBt~e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] themet2e2: args2Role-mention-ngram: THEME conformers withtwe1: trigger-arg-path: Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltDe2: trigger-arg-path: bound >dobj [lemma='GDP'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: bound H-Ras A59Gt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt'e1: args2Role-mention-ngram: ( PDB 1LF0t$e2: args2Role-mention-ngram: the GTPtce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='GDP'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: A59G crystal structuretue2: trigger-arg-path: bound >nsubj [lemma='rmsd'] >prep_of [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt/e1: args2Role-mention-ngram: H-Ras A59G crystaltVe2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass controlled:Generic_eventt'e1: ents2Label-mention-ngram: the firstt@e1: trigger-arg-path: binds >conj_and >dobj Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: of glycolysis ,tie2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass [lemma='interaction'] controlled:Generic_eventt=e1: trigger-arg-path: binds >nsubj [lemma='hexokinase'] themet,e1: ents2Label-mention-ngram: the first steptEe2: trigger-arg-path: lemmatizedTrigger=enhance >agent >nn controllert1e1: ents2Label-mention-ngram: responsible for thetEe1: trigger-arg-path: binds:Binding >nsubj [lemma='hexokinase'] themetie2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent >nn controller:Simple_chemicalt}e2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='deprivation'] >nn [lemma='glucose'] controller:Simple_chemicalt!e1: args2Role-mention-ngram: steptYe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass controlledt*e1: ents2Label-mention-ngram: glycolysis ,tJe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj themetDe2: trigger-arg-path: enhanced >agent >nn controller:Simple_chemicalt,e1: args2Role-mention-ngram: responsible fort$e1: ents2Label-mention-ngram: FAMILYtYe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent >nn controllert5e1: args2Role-mention-ngram: the mitochondria locatedt*e1: ents2Label-mention-ngram: mitochondriat'e1: ents2Label-mention-ngram: II ( HKIIt$e1: ents2Label-mention-ngram: HKII )t$e1: args2Role-mention-ngram: for thete1: incoming: conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: mitochondria located enzymet-e1: ents2Label-mention-ngram: to and inhibitst$e1: ents2Label-mention-ngram: ( HKIIt0e1: ents2Label-mention-ngram: enzyme responsibletVe1: trigger-arg-path: Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] themet%e1: ents2Label-mention-ngram: for thetMe2: trigger-arg-path: enhanced >nsubjpass [lemma='interaction'] Generic_eventtFe1: trigger-arg-path: binds >conj_and >dobj theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: is enhancedtSe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass controlled:Generic_eventtEe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass controlledt^e2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass [lemma='interaction'] controlledt$interceding-token ngrams: , and thatt\e1: trigger-arg-path: binds:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] themetJe2: trigger-arg-path: lemmatizedTrigger=enhance >agent >nn Simple_chemicaltme1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] themetHe2: trigger-arg-path: enhanced:Positive_regulation >agent >nn controllert4e2: trigger-arg-path: enhanced >agent >nn controllert3e2: args2Role-mention-ngram: enhanced by CONTROLLERt?e1: trigger-arg-path: Binding >nsubj [lemma='hexokinase'] themet)e1: args2Role-mention-ngram: binds to andt$e1: ents2Label-mention-ngram: to andt5e2: ents2Label-mention-ngram: interaction is enhancedt0e2: ents2Label-mention-ngram: by SIMPLE_CHEMICALtQe1: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj Gene_or_gene_productt)e1: ents2Label-mention-ngram: responsiblet!e1: args2Role-mention-ngram: HKIItue2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] Simple_chemicaltStrigger-to-trigger-path: e1:binds:Binding >conj_and e2:enhanced:Positive_regulationt'e1: args2Role-mention-ngram: glycolysistge2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass controlled:Generic_eventt!e1: ents2Label-mention-ngram: fortae2: trigger-arg-path: enhanced >agent [lemma='deprivation'] >nn [lemma='glucose'] Simple_chemicaltqe1: trigger-arg-path: binds:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] theme:Gene_or_gene_productt e1: ents2Label-mention-ngram: IIt[e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass [lemma='interaction'] controlledt)e2: ents2Label-mention-ngram: enhanced byt(e1: ents2Label-mention-ngram: glycolysist!e1: ents2Label-mention-ngram: ) ,te2: trigger: enhancedtle2: trigger-arg-path: Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] Simple_chemicaltle2: trigger-arg-path: enhanced >agent [lemma='deprivation'] >nn [lemma='glucose'] controller:Simple_chemicaltke1: trigger-arg-path: Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: first stept)e1: args2Role-mention-ngram: and inhibitst0e1: args2Role-mention-ngram: responsible for thetre2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='deprivation'] >nn [lemma='glucose'] Simple_chemicalt/e1: args2Role-mention-ngram: , the mitochondriat(e2: args2Role-mention-ngram: enhanced byt)e1: ents2Label-mention-ngram: FAMILY II (t&e2: ents2Label-mention-ngram: enhancedt*e1: args2Role-mention-ngram: for the firsttLe1: trigger-arg-path: binds:Binding >nsubj [lemma='hexokinase'] theme:Familytae2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controller:Simple_chemicalte1: args2Role-mention-ngram: IIt#e1: args2Role-mention-ngram: ( HKIItXe2: trigger-arg-path: enhanced >nsubjpass [lemma='interaction'] controlled:Generic_eventt4e2: trigger-arg-path: enhanced >nsubjpass controlledtke1: trigger-arg-path: binds:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: ) , thet8e1: args2Role-mention-ngram: mitochondria located enzymetre2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventt#e1: args2Role-mention-ngram: HKII )t}e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hexokinase'] theme:Familyt-e1: ents2Label-mention-ngram: responsible fort*e1: args2Role-mention-ngram: first step oft'e1: ents2Label-mention-ngram: FAMILY IIt+e1: args2Role-mention-ngram: inhibits THEMEtee1: trigger-arg-path: Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] Gene_or_gene_productt$e1: args2Role-mention-ngram: ) , thet(e2: args2Role-mention-ngram: is enhancedtHe2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass controlledt2e1: ents2Label-mention-ngram: mitochondria locatedt!e1: args2Role-mention-ngram: II (t$e1: ents2Label-mention-ngram: enzymet9e2: ents2Label-mention-ngram: enhanced by SIMPLE_CHEMICALt'e1: args2Role-mention-ngram: first steptwe2: trigger-arg-path: Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controllert#e1: args2Role-mention-ngram: to andtBe2: trigger-arg-path: enhanced >nsubjpass controlled:Generic_eventt$e1: args2Role-mention-ngram: , bindst*e1: ents2Label-mention-ngram: binds to andt+e2: args2Role-mention-ngram: is enhanced byt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] Simple_chemicaltte1: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: of glycolysist(e1: args2Role-mention-ngram: responsiblet,e2: ents2Label-mention-ngram: is enhanced bytFe1: trigger-arg-path: Binding >nsubj [lemma='hexokinase'] theme:Familyt%e1: ents2Label-mention-ngram: , bindst0e1: ents2Label-mention-ngram: , the mitochondriatDe2: trigger-arg-path: Positive_regulation >agent >nn Simple_chemicaltWe1: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: located enzymet,e1: args2Role-mention-ngram: of glycolysis ,t7e2: trigger-arg-path: enhanced >nsubjpass Generic_eventtHe1: trigger-arg-path: binds:Binding >conj_and >dobj Gene_or_gene_productt.e1: ents2Label-mention-ngram: the mitochondriat%e1: args2Role-mention-ngram: THEME IItge2: trigger-arg-path: Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controllertetrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='enhance'] e2:enhanced:Positive_regulationtMe2: trigger-arg-path: enhanced:Positive_regulation >agent >nn Simple_chemicalt"e1: ents2Label-mention-ngram: HKIItoe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass [lemma='interaction'] controlledt'e1: args2Role-mention-ngram: , binds tot^e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent >nn Simple_chemicaltBe1: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj themet|e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] Gene_or_gene_productt/e1: args2Role-mention-ngram: glycolysis , bindste1: outgoing: >numtFe1: trigger-arg-path: binds:Binding >nsubj [lemma='hexokinase'] Familyt(e1: ents2Label-mention-ngram: , binds tot,e1: args2Role-mention-ngram: to and inhibitstUe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hexokinase'] theme:FamilytUe2: trigger-arg-path: lemmatizedTrigger=enhance >agent >nn controller:Simple_chemicaltle2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventt#e1: args2Role-mention-ngram: enzymetDe1: trigger-arg-path: binds >nsubj [lemma='hexokinase'] theme:FamilytXe2: trigger-arg-path: enhanced:Positive_regulation >agent >nn controller:Simple_chemicalt)e1: args2Role-mention-ngram: mitochondriat%e1: args2Role-mention-ngram: HKII ) ,t3e1: args2Role-mention-ngram: enzyme responsible fort>e1: trigger-arg-path: binds >nsubj [lemma='hexokinase'] Familyt"e1: ents2Label-mention-ngram: stept e1: args2Role-mention-ngram: ) ,t1e1: trigger-arg-path: binds >conj_and >dobj themet+e1: args2Role-mention-ngram: the first stept?e2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controller:Simple_chemicalt4e1: ents2Label-mention-ngram: enzyme responsible fort'e1: args2Role-mention-ngram: THEME II (t@e1: trigger-arg-path: Binding >nsubj [lemma='hexokinase'] FamilytJe2: trigger-arg-path: enhanced >nsubjpass [lemma='interaction'] controlledt-interceding-tokens-full-span: , and that thistce1: trigger-arg-path: binds >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: HKII ) ,t/e1: args2Role-mention-ngram: step of glycolysist1e1: args2Role-mention-ngram: mitochondria locatedtKe2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass Generic_eventt/e1: args2Role-mention-ngram: and inhibits THEMEt$e1: args2Role-mention-ngram: locatedt e1: args2Role-mention-ngram: fort0e1: ents2Label-mention-ngram: glycolysis , bindst-e1: args2Role-mention-ngram: the mitochondriatme2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='deprivation'] >nn [lemma='glucose'] controllert"e1: ents2Label-mention-ngram: II (tYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj Gene_or_gene_productt7e1: args2Role-mention-ngram: located enzyme responsiblet"e1: args2Role-mention-ngram: firstt%e1: ents2Label-mention-ngram: step oft)e1: args2Role-mention-ngram: glycolysis ,tOe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hexokinase'] Familyt$e1: args2Role-mention-ngram: step oftHe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass Generic_eventt#e1: ents2Label-mention-ngram: firstt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hexokinase'] themetashortest-path: conj_and [lemma='enhance'] >nsubjpass [lemma='interaction']tee1: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] themet?e1: ents2Label-mention-ngram: and inhibits GENE_OR_GENE_PRODUCTtOe2: trigger-arg-path: Positive_regulation >agent >nn controller:Simple_chemicaltpe2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='deprivation'] >nn [lemma='glucose'] controllert,e1: ents2Label-mention-ngram: located enzymet+e1: ents2Label-mention-ngram: for the firstt*e1: args2Role-mention-ngram: of glycolysist#e1: ents2Label-mention-ngram: , thet"e1: args2Role-mention-ngram: , thet&e1: args2Role-mention-ngram: the firstt;e1: ents2Label-mention-ngram: inhibits GENE_OR_GENE_PRODUCTt%e1: args2Role-mention-ngram: ( HKII )t9e1: trigger-arg-path: binds:Binding >conj_and >dobj themet6e1: ents2Label-mention-ngram: the mitochondria locatedtWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hexokinase'] Familytie1: trigger-arg-path: binds >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass Generic_eventt0e1: ents2Label-mention-ngram: step of glycolysist+e1: ents2Label-mention-ngram: first step oft*shortest-path: conj_and >nsubjpasst^e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass [lemma='interaction'] Generic_eventt%e1: ents2Label-mention-ngram: locatedtTe1: trigger-arg-path: binds >conj_and [lemma='inhibit'] >dobj [lemma='mtorc1'] themet8e1: ents2Label-mention-ngram: located enzyme responsibletNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hexokinase'] themet&e1: ents2Label-mention-ngram: ( HKII )t%e2: args2Role-mention-ngram: enhancedt9e2: trigger-arg-path: enhanced >agent >nn Simple_chemicaltNe1: trigger-arg-path: binds:Binding >conj_and >dobj theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: enzyme responsiblet&e1: args2Role-mention-ngram: II ( HKIIt3e2: args2Role-mention-ngram: CONTROLLED is enhancedt\e2: trigger-arg-path: enhanced >agent [lemma='deprivation'] >nn [lemma='glucose'] controllertRe1: trigger-arg-path: binding:Binding >conj_or >prep_of theme:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: or by bindingtke2: trigger-arg-path: lemmatizedTrigger=complex:Binding e1: trigger-arg-path: binding >prep_of [lemma='grb2-so'] themet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding >conj_or >prep_of Gene_or_gene_producttQe2: trigger-arg-path: complex conj_or >prep_of Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_producttKe2: trigger-arg-path: complex e1: trigger-arg-path: Binding >prep_of [lemma='grb2-so'] themet,e1: ents2Label-mention-ngram: by binding andt5e1: trigger-arg-path: Binding >conj_or >prep_of themet(e1: ents2Label-mention-ngram: by bindingt*e1: ents2Label-mention-ngram: SHARED or bytde1: trigger-arg-path: Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_productt0e1: args2Role-mention-ngram: and phosphorylationt^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or >prep_of Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttFe1: trigger-arg-path: binding:Binding >prep_of [lemma='grb2-so'] themetde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or >prep_of theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: or by bindingtge1: trigger-arg-path: lemmatizedTrigger=binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themetYe2: trigger-arg-path: complex:Binding conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttEe1: ents2Label-mention-ngram: phosphorylation of GENE_OR_GENE_PRODUCTtde1: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >conj_or >prep_of theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='grb2-so'] Gene_or_gene_producttje1: trigger-arg-path: Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttDe1: trigger-arg-path: binding >conj_or >prep_of Gene_or_gene_productt?trigger-to-trigger-path: e1:binding:Binding prep_to [lemma='complex'] e2:complex:BindingtPe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] themet_e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=binding >conj_or >prep_of themet'shortest-path: prep_totXe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='grb2-so'] themetDe2: trigger-arg-path: complex:Binding conj_or >prep_of theme:Gene_or_gene_producttXshortest-path: prep_to [lemma='grb2']tMe1: trigger-arg-path: binding >prep_of [lemma='grb2-so'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: binding and phosphorylationtconj_or >prep_of themetQe2: trigger-arg-path: Binding conj_or >prep_of themetWtrigger-to-trigger-path: e1:binding:Binding prep_to e2:complex:BindingtDe1: trigger-arg-path: Binding >conj_or >prep_of Gene_or_gene_producttSe1: trigger-arg-path: binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt5e1: trigger-arg-path: binding >conj_or >prep_of themetee1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex prep_of [lemma='grb2-so'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themet"e1: args2Role-mention-ngram: or byt3e1: args2Role-mention-ngram: and phosphorylation oftMe1: trigger-arg-path: Binding >prep_of [lemma='grb2-so'] Gene_or_gene_productt]e1: trigger-arg-path: binding:Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themetje1: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themet+e1: args2Role-mention-ngram: by binding andtJe1: trigger-arg-path: binding >conj_or >prep_of theme:Gene_or_gene_producttUe1: trigger-arg-path: binding >conj_or [lemma='binding'] >prep_of [lemma='shc'] themetme1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt[e1: trigger-arg-path: binding:Binding >prep_of [lemma='grb2-so'] theme:Gene_or_gene_productt8e1: args2Role-mention-ngram: binding and phosphorylationt)e1: ents2Label-mention-ngram: binding andt+interceding-token ngrams: greater than thatt:interceding-token ngrams: phosphorylation was insufficientt-interceding-token ngrams: phosphorylation wastYe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='cr'] Gene_or_gene_productt&interceding-token ngrams: insufficientt?trigger-to-trigger-path: e1:increased:Positive_regulation >conj_and [lemma='insufficient'] >prep_for [lemma='insulin'] >vmod [lemma='stimulate'] e2:stimulated:Positive_activationtze1: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] Phosphorylationt]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='cr'] controller:Gene_or_gene_productt2interceding-token ngrams: and AKT1 phosphorylationt&interceding-token ngrams: greater thanthe2: trigger-arg-path: stimulated >dobj [lemma='uptake'] >nn [lemma='glucose'] controlled:Simple_chemicaltBe1: trigger-arg-path: Positive_regulation >xcomp >nsubj controlledt!interceding-token ngrams: WT micet"interceding-token ngrams: found intRe1: trigger-arg-path: Positive_regulation >xcomp >nsubj controlled:PhosphorylationtRe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='cr'] controllerthe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation xcomp >nsubj controlledt.interceding-token ngrams: libitum levels foundtutrigger-to-trigger-path: e1:increased:Positive_regulation >conj_and >prep_for >vmod e2:stimulated:Positive_activationtinterceding-token ngrams: of adt*interceding-token ngrams: found in insulintge1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='cr'] controller:Gene_or_gene_productt?interceding-tokens-full-span: greater than that of ad libitum levels found in insulin stimulated WT mice , and AKT1 phosphorylation was insufficient fortVe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj [lemma='cr'] controller:Gene_or_gene_producttZe1: trigger-arg-path: increased:Positive_regulation >nsubj controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='cr'] controllertfe2: trigger-arg-path: Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt!interceding-token ngrams: libitumtLe2: trigger-arg-path: Positive_activation dobj >nn controlled:Simple_chemicalt8e2: ents2Label-mention-ngram: stimulated SIMPLE_CHEMICALt)shortest-path: conj_and >prep_fortinterceding-token ngrams: AKT1t"interceding-token ngrams: and AKT1tEe1: trigger-arg-path: increased:Positive_regulation >nsubj controllertFe1: trigger-arg-path: increased >nsubj controller:Gene_or_gene_producttCe2: trigger-arg-path: stimulated dobj [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicaltVe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn controlled:Simple_chemicaltXe2: trigger-arg-path: stimulated >dobj [lemma='uptake'] >nn [lemma='glucose'] controlledteshortest-path: conj_and [lemma='insufficient'] >prep_for [lemma='insulin']tRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='cr'] Gene_or_gene_productt)interceding-token ngrams: levels found intQe1: trigger-arg-path: increased:Positive_regulation >xcomp >nsubj Phosphorylationt$interceding-token ngrams: mice , andt}e1: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] Phosphorylationt~e1: trigger-arg-path: Positive_regulation >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlled:PhosphorylationtZe2: trigger-arg-path: stimulated:Positive_activation xcomp >nsubj controlled:Phosphorylationt,interceding-token ngrams: insulin stimulatedtVe2: trigger-arg-path: Positive_activation dobj >nn controlled:Simple_chemicaltqe2: trigger-arg-path: stimulated:Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicaltye2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='uptake'] >nn [lemma='glucose'] controlled:Simple_chemicalt1e1: args2Role-mention-ngram: CONTROLLER increasedt^e2: trigger-arg-path: lemmatizedTrigger=stimulate xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlled:PhosphorylationtCe1: ents2Label-mention-ngram: increased GENE_OR_GENE_PRODUCT Ser473t!interceding-token ngrams: greatertOe2: trigger-arg-path: stimulated:Positive_activation dobj [lemma='uptake'] >nn [lemma='glucose'] controlledtae2: trigger-arg-path: stimulated:Positive_activation xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtqe2: trigger-arg-path: Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] controlled:Simple_chemicaltnsubj [lemma='cr'] Gene_or_gene_productt1e2: trigger-arg-path: stimulated dobj >nn Simple_chemicalt#interceding-token ngrams: than thattre2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation e1: trigger-arg-path: increased >nsubj [lemma='cr'] controllertue1: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] PhosphorylationtWe2: trigger-arg-path: lemmatizedTrigger=stimulate dobj [lemma='uptake'] >nn [lemma='glucose'] controlledt'interceding-token ngrams: of ad libitumtle2: trigger-arg-path: stimulated:Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] controlledtxe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='cr'] controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >nsubj Phosphorylationt$interceding-token ngrams: in insulint/interceding-token ngrams: insulin stimulated WTtGe1: trigger-arg-path: Positive_regulation >xcomp >nsubj Phosphorylationt;e1: trigger-arg-path: increased >nsubj Gene_or_gene_productt#interceding-token ngrams: WT mice ,t5e2: trigger-arg-path: stimulated >dobj >nn controlledtKe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn Simple_chemicaltie2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj Gene_or_gene_productt$e1: ents2Label-mention-ngram: Ser473tne2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=stimulate xcomp >nsubj controlledtdobj >nn controlledt;e2: trigger-arg-path: stimulated dobj [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT Ser473tNe2: trigger-arg-path: stimulated:Positive_activation >dobj >nn Simple_chemicaltDe2: trigger-arg-path: Positive_activation xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] Phosphorylationt?e1: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationtae2: trigger-arg-path: Positive_activation xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlledtinterceding-token ngrams: foundt.interceding-token ngrams: was insufficient fort*interceding-token ngrams: was insufficienttke2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj [lemma='cr'] controllert?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] controlled:Simple_chemicaltMe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulated SIMPLE_CHEMICALtMe2: trigger-arg-path: stimulated xcomp >nsubj controlled:Phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='cr'] controller:Gene_or_gene_producttxcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] PhosphorylationtWe2: trigger-arg-path: stimulated:Positive_activation dobj [lemma='uptake'] >nn [lemma='glucose'] controlledtinterceding-token ngrams: micetHe1: trigger-arg-path: increased >nsubj [lemma='cr'] Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn controlledt+interceding-token ngrams: ad libitum levelstOe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='cr'] controllertLe1: trigger-arg-path: increased:Positive_regulation >xcomp >nsubj controlledt$interceding-token ngrams: stimulatedtCe2: trigger-arg-path: Positive_activation >dobj >nn Simple_chemicaltIe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >nsubj controlledt,interceding-token ngrams: stimulated WT micetde1: trigger-arg-path: increased >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlledtbe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >nsubj Phosphorylationt\e1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='cr'] Gene_or_gene_producttFe2: trigger-arg-path: stimulated xcomp >nsubj controlled:Phosphorylationt=e1: trigger-arg-path: increased >xcomp >nsubj Phosphorylationt&interceding-token ngrams: than that oftYe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >nsubj controlled:Phosphorylationt|e2: trigger-arg-path: stimulated:Positive_activation >dobj [lemma='uptake'] >nn [lemma='glucose'] controlled:Simple_chemicaltZe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn controlledt:e2: trigger-arg-path: stimulated >dobj >nn Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationt)interceding-token ngrams: phosphorylationt'interceding-token ngrams: stimulated WTtEe2: trigger-arg-path: stimulated:Positive_activation xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlledtOe2: trigger-arg-path: Positive_activation xcomp [lemma='greater'] >nsubj [lemma='phosphorylation'] controlledt/interceding-token ngrams: in insulin stimulatedtIe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT Ser473 phosphorylationtNe2: trigger-arg-path: Positive_activation >dobj >nn controlled:Simple_chemicalt}e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation nsubj controllertinterceding-token ngrams: adt$interceding-token ngrams: , and AKT1tEe2: trigger-arg-path: stimulated >dobj >nn controlled:Simple_chemicalt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ezh2'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ezh2'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: in increasedtze1: trigger-arg-path: interacts >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] site:Sitet+e1: args2Role-mention-ngram: increased SITEt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttve1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] theme:Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ezh2'] themet)e1: args2Role-mention-ngram: resulting int?e1: trigger-arg-path: interacts:Binding >vmod >prep_in >nn Sitet7e1: trigger-arg-path: interacts >vmod >prep_in >nn sitetctrigger-to-trigger-path: e1:interacts:Binding >vmod >prep_in >amod e2:increased:Positive_regulationtLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ezh2'] themetse1: trigger-arg-path: Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] sitetJe1: trigger-arg-path: interacts >nsubj [lemma='ezh2'] Gene_or_gene_producttle1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] site:SitetUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod >prep_in >nn site:Sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] SitetPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod >prep_in >nn sitet9e1: trigger-arg-path: Binding >nsubj [lemma='ezh2'] themet}e1: trigger-arg-path: interacts:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] SitetHe1: trigger-arg-path: lemmatizedTrigger=interact >vmod >prep_in >nn sitete1: args2Role-mention-ngram: intfe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt7e1: trigger-arg-path: interacts >vmod >prep_in >nn Sitet/e1: args2Role-mention-ngram: methylates THEME ,tse1: trigger-arg-path: Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] Sitet.e1: args2Role-mention-ngram: THEME , resultingt5e1: trigger-arg-path: Binding >vmod >prep_in >nn sitetHe1: trigger-arg-path: Binding >nsubj [lemma='ezh2'] Gene_or_gene_producttue1: trigger-arg-path: interacts >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] sitet?e1: trigger-arg-path: lemmatizedTrigger=interact >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] site:Sitetce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ezh2'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ezh2'] themet(e1: args2Role-mention-ngram: , resultingte1: SITE: 3tre1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] themetPe1: trigger-arg-path: interacts >nsubj [lemma='ezh2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=interact >vmod >prep_in >nn SitetDe1: trigger-arg-path: interacts:Binding >vmod >prep_in >nn site:Sitetue1: trigger-arg-path: interacts >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] Sitet5e1: trigger-arg-path: Binding >vmod >prep_in >nn Sitet.e1: args2Role-mention-ngram: in increased SITEtYe1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='stat3'] themet+e1: args2Role-mention-ngram: , resulting intMe1: trigger-arg-path: lemmatizedTrigger=interact >vmod >prep_in >nn site:Sitet?trigger-to-trigger-path: e1:interacts:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >amod [lemma='increase'] e2:increased:Positive_regulationtpe1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ezh2'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod >prep_in >nn Sitet?e1: trigger-arg-path: lemmatizedTrigger=interact >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] sitete1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='stat3'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] theme:Gene_or_gene_producttae1: trigger-arg-path: interacts:Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] themet;e1: trigger-arg-path: interacts >nsubj [lemma='ezh2'] themetxe1: trigger-arg-path: Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] site:Sitetye1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt3e1: args2Role-mention-ngram: resulting in increasedtNe1: trigger-arg-path: Binding >nsubj [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] site:Sitetvmod >prep_in >nn site:SitetWe1: trigger-arg-path: Binding >conj_and [lemma='methylate'] >dobj [lemma='stat3'] themet?e1: trigger-arg-path: lemmatizedTrigger=interact >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] Sitetae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ezh2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ezh2'] theme:Gene_or_gene_producttne1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='stat3'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts:Binding >vmod >prep_in >nn sitet}e1: trigger-arg-path: interacts:Binding >vmod [lemma='result'] >prep_in [lemma='phosphorylation'] >nn [lemma='tyrosine'] sitet:e1: trigger-arg-path: Binding >vmod >prep_in >nn site:Sitet&e1: args2Role-mention-ngram: resultingtje1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='methylate'] >dobj [lemma='stat3'] themethe1: trigger-arg-path: interacts >conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: constitutively totIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mek'] themet1e1: args2Role-mention-ngram: binds constitutivelytOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] themet8e2: trigger-arg-path: binds >prep_to [lemma='mek'] themet4e2: args2Role-mention-ngram: constitutively to THEMEt6e1: ents2Label-mention-ngram: constitutively to SHAREDt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mek'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: binds constitutively tot.e2: args2Role-mention-ngram: constitutively totMe2: trigger-arg-path: Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_productt@e2: trigger-arg-path: binds:Binding >prep_to [lemma='mek'] themet,e2: ents2Label-mention-ngram: constitutivelytGe2: trigger-arg-path: binds >prep_to [lemma='mek'] Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='ksr'] themet4e1: args2Role-mention-ngram: binds constitutively tot1e2: args2Role-mention-ngram: binds constitutivelytQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mek'] themet6e2: ents2Label-mention-ngram: constitutively to SHAREDt:e2: trigger-arg-path: Binding >prep_to [lemma='mek'] themet+e2: args2Role-mention-ngram: constitutivelytMe2: trigger-arg-path: binds >prep_to [lemma='mek'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: constitutively totMe2: trigger-arg-path: binds:Binding >nsubj [lemma='ksr'] Gene_or_gene_producttKe2: trigger-arg-path: binds >nsubj [lemma='ksr'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: binds constitutivelyt.e1: args2Role-mention-ngram: constitutively totIe2: trigger-arg-path: Binding >prep_to [lemma='mek'] Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='ksr'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: SHARED binds constitutivelytUe2: trigger-arg-path: binds:Binding >prep_to [lemma='mek'] theme:Gene_or_gene_productt4e2: args2Role-mention-ngram: binds constitutively tot4e1: args2Role-mention-ngram: constitutively to THEMEtfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mek'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='ksr'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mek'] Gene_or_gene_productt7e2: args2Role-mention-ngram: THEME binds constitutivelyt>e2: trigger-arg-path: binds:Binding >nsubj [lemma='ksr'] themetOe2: trigger-arg-path: Binding >prep_to [lemma='mek'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: binds constitutivelytde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] theme:Gene_or_gene_productt9e2: ents2Label-mention-ngram: SHARED binds constitutivelyt8e2: trigger-arg-path: Binding >nsubj [lemma='ksr'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ksr'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ksr'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: binds constitutively tot^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ksr'] Gene_or_gene_productt7e1: args2Role-mention-ngram: THEME binds constitutivelytOe2: trigger-arg-path: binds:Binding >prep_to [lemma='mek'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ksr'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mek'] theme:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn Bindingtue1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Familyt=e2: trigger-arg-path: binding:Binding >nn [lemma='ra'] FamilytBe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn Familytye1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledtxe1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controlledt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp theme:Gene_or_gene_producttVe1: trigger-arg-path: directly activated:Positive_regulation agent >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:Familyt/e1: ents2Label-mention-ngram: by SHARED bindingt@e2: trigger-arg-path: binding xcomp Gene_or_gene_productt@e2: trigger-arg-path: Binding xcomp Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:FamilytOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] Familyt4e1: args2Role-mention-ngram: activated by CONTROLLERtNe1: trigger-arg-path: Positive_regulation agent >nn controller:Familytdtrigger-to-trigger-path: e1:directly activated:Positive_regulation agent e2:binding:Bindingtke1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controllertte2: trigger-arg-path: lemmatizedTrigger=binding xcomp [lemma='p110'] Gene_or_gene_productt'e2: args2Role-mention-ngram: binding totGe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] Familyt-e2: args2Role-mention-ngram: THEME binding tot[e2: trigger-arg-path: binding:Binding xcomp [lemma='p110'] themetGe1: trigger-arg-path: Positive_regulation agent >nn controlledtZe1: trigger-arg-path: directly activated:Positive_regulation agent >nn controlledte1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controller:Familyt?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllert5e2: trigger-arg-path: binding >nn [lemma='ra'] FamilytCe2: trigger-arg-path: lemmatizedTrigger=binding xcomp themet?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] BindingtCe2: trigger-arg-path: binding:Binding >nn [lemma='ra'] theme:Familytee2: trigger-arg-path: lemmatizedTrigger=binding xcomp [lemma='p110'] themetMe1: trigger-arg-path: directly activated agent >nn controller:FamilytSshortest-path: agent [lemma='binding'] >nn [lemma='ra']t0e2: trigger-arg-path: binding:Binding >nn FamilytFe1: trigger-arg-path: directly activated agent >nn controlledtBe1: trigger-arg-path: directly activated agent >nn Familyt1e1: ents2Label-mention-ngram: activated by SHAREDtXe2: trigger-arg-path: lemmatizedTrigger=binding xcomp theme:Gene_or_gene_productt/e2: trigger-arg-path: binding:Binding >nn themetCe1: trigger-arg-path: Positive_regulation agent >nn FamilytOe1: trigger-arg-path: Positive_regulation agent >nn controlled:Bindingthe2: trigger-arg-path: Binding xcomp [lemma='p110'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:directly activated:Positive_regulation agent [lemma='binding'] e2:binding:Bindingtnn [lemma='ra'] themet2e1: args2Role-mention-ngram: directly activated byt^e1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controller:FamilytNe1: trigger-arg-path: directly activated agent >nn controlled:BindingtNe2: trigger-arg-path: binding:Binding xcomp theme:Gene_or_gene_productt?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt6e2: trigger-arg-path: binding:Binding >nn theme:Familytxe1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controllert!shortest-path: agent >nnt5e1: args2Role-mention-ngram: by CONTROLLER CONTROLLEDt?e1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controlled:BindingtSe2: trigger-arg-path: binding xcomp [lemma='p110'] themetye1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllert9e2: trigger-arg-path: binding:Binding xcomp themetUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] theme:Familytge1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn FamilytFe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] themetDe1: trigger-arg-path: Positive_regulation agent >nn Bindingt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledt3e1: ents2Label-mention-ngram: directly activated byt;e2: trigger-arg-path: binding >nn [lemma='ra'] theme:FamilytTe1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn BindingtCe1: trigger-arg-path: directly activated agent >nn BindingtSe1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn Familyt?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] FamilytHe2: trigger-arg-path: binding:Binding xcomp Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Familytre1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controller:Familytbe2: trigger-arg-path: Binding xcomp [lemma='p110'] Gene_or_gene_producttZe1: trigger-arg-path: directly activated:Positive_regulation agent >nn controllertFe2: trigger-arg-path: binding xcomp theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp [lemma='p110'] Gene_or_gene_producttGe1: trigger-arg-path: Positive_regulation agent >nn controllertve1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Bindingt9e2: trigger-arg-path: lemmatizedTrigger=binding >nn themetZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp Gene_or_gene_producttFe1: trigger-arg-path: directly activated agent >nn controllertue1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] BindingtMe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] theme:Familyt-e2: args2Role-mention-ngram: binding to THEMEtpe2: trigger-arg-path: binding:Binding xcomp [lemma='p110'] theme:Gene_or_gene_producttae1: trigger-arg-path: directly activated:Positive_regulation agent >nn controller:Familyt1e2: trigger-arg-path: Binding xcomp themet?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controlled:BindingtFe2: trigger-arg-path: Binding xcomp theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controlledtbe2: trigger-arg-path: binding xcomp [lemma='p110'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] BindingtRe2: trigger-arg-path: lemmatizedTrigger=binding xcomp Gene_or_gene_productt/e1: args2Role-mention-ngram: directly activatedt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp [lemma='p110'] theme:Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn themetNe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] themetme2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp [lemma='p110'] themette1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] Familyt/e1: ents2Label-mention-ngram: binding to SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controllert?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:Familyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Bindingtke1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controlledtHe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn theme:Familythe2: trigger-arg-path: binding xcomp [lemma='p110'] theme:Gene_or_gene_productt'e2: trigger-arg-path: binding >nn themet1e2: trigger-arg-path: binding xcomp themetze2: trigger-arg-path: lemmatizedTrigger=binding xcomp [lemma='p110'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding xcomp [lemma='p110'] themetWe1: trigger-arg-path: directly activated:Positive_regulation agent >nn Bindingtbe1: trigger-arg-path: directly activated:Positive_regulation agent >nn controlled:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controller:Familyte1: CONTROLLER: 3t@e2: trigger-arg-path: lemmatizedTrigger=binding >nn theme:Familyte1: trigger: directly activatedt0e1: ents2Label-mention-ngram: directly activatedtse1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controlled:Bindingte1: CONTROLLED: 3t?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlledt(e2: trigger-arg-path: binding >nn Familyt:e2: trigger-arg-path: lemmatizedTrigger=binding >nn Familyt4e2: trigger-arg-path: binding >nn [lemma='ra'] themet?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controllertje2: trigger-arg-path: binding:Binding xcomp [lemma='p110'] Gene_or_gene_productt.e2: trigger-arg-path: binding >nn theme:Familyt_e1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controlled:BindingtWe1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controllertKe2: trigger-arg-path: lemmatizedTrigger=binding:Binding xcomp themet?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controlled:Bindingt=e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn themet_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] themet#anaphor-basic: trigger: associationt'interceding-token ngrams: at Ser536 andt8e2: ents2Label-mention-ngram: SHARED corepressor returnst?shortest-path: prep_at [lemma='ser2410'] >vmod [lemma='prevent'] >dobj [lemma='association']t]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] themet4e1: ents2Label-mention-ngram: corepressor returns tot-e1: ents2Label-mention-ngram: chromatin boundt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] themetPe2: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themet-interceding-token ngrams: and p65 heterodimert1e2: ents2Label-mention-ngram: the chromatin boundtLe2: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] themetee2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: returnstPe1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themetRe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn theme:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt'interceding-token ngrams: the chromatint0e1: args2Role-mention-ngram: the chromatin boundt)e2: ents2Label-mention-ngram: corepressort'e2: args2Role-mention-ngram: returns totLe1: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] themet#interceding-token ngrams: after thet/e1: args2Role-mention-ngram: chromatin bound NFt)e2: args2Role-mention-ngram: bound NF andtie2: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_producttce1: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt(interceding-token ngrams: to prevent thetEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn themet6e1: args2Role-mention-ngram: THEME corepressor returnst"interceding-token ngrams: IKKalphat$e2: args2Role-mention-ngram: returnst'interceding-token ngrams: chromatin andtKe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn Gene_or_gene_producttAe1: trigger-arg-path: bound >nsubj >nn theme:Gene_or_gene_productt_e1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: the chromatint]e2: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt+e2: args2Role-mention-ngram: returns to thetbtrigger-to-trigger-path: e1:bound:Binding prep_at >vmod >dobj e2:association:Generic_eventt4e1: trigger-arg-path: bound:Binding >nsubj >nn themetce1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_producttCe1: trigger-arg-path: Binding >nsubj >nn theme:Gene_or_gene_productt-interceding-token ngrams: phosphorylates botht1interceding-token ngrams: phosphorylates both p65t.e2: ents2Label-mention-ngram: to the chromatint1e2: ents2Label-mention-ngram: corepressor returnst%interceding-token ngrams: immediatelytBe1: trigger-arg-path: bound:Binding >dobj >nn Gene_or_gene_productt'interceding-token ngrams: and chromatint(e2: ents2Label-mention-ngram: returns tot=e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn themet3e1: trigger-arg-path: bound:Binding >dobj >nn themet-interceding-token ngrams: active p50-RelA andt0e1: args2Role-mention-ngram: corepressor returnst,interceding-token ngrams: with the chromatint.e2: args2Role-mention-ngram: THEME corepressort)interceding-token ngrams: recruitment andt+e2: ents2Label-mention-ngram: NF and SHAREDt!interceding-token ngrams: SMRT att'e2: ents2Label-mention-ngram: chromatintce2: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themet%interceding-token ngrams: heterodimertae1: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt$interceding-token ngrams: promoter ,t0e2: args2Role-mention-ngram: the chromatin boundtAe2: trigger-arg-path: bound >nsubj >nn theme:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT corepressort$e1: ents2Label-mention-ngram: NF andtIe1: trigger-arg-path: bound:Binding >nsubj >nn theme:Gene_or_gene_productt;e2: trigger-arg-path: bound >nsubj >nn Gene_or_gene_productt(e2: args2Role-mention-ngram: corepressort0e1: ents2Label-mention-ngram: chromatin bound NFtae2: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: corepressort)interceding-token ngrams: Ser536 and SMRTt6e2: args2Role-mention-ngram: THEME corepressor returnst$interceding-token ngrams: at Ser2410t(interceding-token ngrams: complex almosttinterceding-tokens-full-span: complex almost immediately after the active p50-RelA and p65 heterodimer binds to the promoter , IKKalpha remains associated with the chromatin and phosphorylates both p65 at Ser536 and SMRT at Ser2410 to prevent the recruitment and chromatintinterceding-token ngrams: SMRTt"interceding-token ngrams: and SMRTt-e2: args2Role-mention-ngram: to the chromatint.e2: trigger-arg-path: Binding >nsubj >nn themet'e1: args2Role-mention-ngram: returns tot6interceding-token ngrams: chromatin and phosphorylatest"interceding-token ngrams: both p65tte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_producttce2: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt$interceding-token ngrams: the activet)e1: args2Role-mention-ngram: bound NF andt interceding-token ngrams: Ser536tYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:Gene_or_gene_productt@e1: trigger-arg-path: bound >dobj >nn theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: returns to thet e1: ents2Label-mention-ngram: NFt0e2: ents2Label-mention-ngram: SHARED corepressortce1: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt]e1: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themet)interceding-token ngrams: the recruitmenttee2: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt-interceding-token ngrams: the recruitment andt$interceding-token ngrams: Ser2410 tot&e2: args2Role-mention-ngram: chromatintee1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themetNe2: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themet.e1: ents2Label-mention-ngram: to the chromatint$interceding-token ngrams: to preventt(e1: ents2Label-mention-ngram: returns tot&e1: args2Role-mention-ngram: chromatint+e1: trigger-arg-path: bound >dobj >nn themet interceding-token ngrams: almostt)e2: args2Role-mention-ngram: NF and THEMEtle2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn themet0e2: args2Role-mention-ngram: corepressor returnst%interceding-token ngrams: and SMRT attZe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn theme:Gene_or_gene_producttinterceding-token ngrams: attCe1: trigger-arg-path: bound:Binding >nsubj >nn Gene_or_gene_productt;e1: trigger-arg-path: bound >nsubj >nn Gene_or_gene_productt(e1: args2Role-mention-ngram: corepressort%e2: args2Role-mention-ngram: bound NFt0e2: ents2Label-mention-ngram: chromatin bound NFt,interceding-token ngrams: and phosphorylatest$e2: ents2Label-mention-ngram: NF andtLe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themete1: args2Role-mention-ngram: NFt#e1: args2Role-mention-ngram: NF andt*e1: args2Role-mention-ngram: the chromatint e2: ents2Label-mention-ngram: NFt$interceding-token ngrams: Ser536 andt*interceding-token ngrams: after the activetCe2: trigger-arg-path: Binding >nsubj >nn theme:Gene_or_gene_producttTe1: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themetTe2: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themetFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT corepressor returnst5interceding-token ngrams: IKKalpha remains associatedt/e2: args2Role-mention-ngram: chromatin bound NFt1interceding-token ngrams: remains associated witht-interceding-token ngrams: associated with thet[e2: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] themetve1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_producttNe1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] themet4anaphor-basic: ents2Label-mention-ngram: associationt+interceding-token ngrams: heterodimer bindstinterceding-token ngrams: bindst]e2: trigger-arg-path: Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt?trigger-to-trigger-path: e1:bound:Binding prep_at [lemma='ser2410'] >vmod [lemma='prevent'] >dobj [lemma='association'] e2:association:Generic_eventt.e1: trigger-arg-path: Binding >nsubj >nn themet*e1: ents2Label-mention-ngram: bound NF andt=e1: trigger-arg-path: Binding >nsubj >nn Gene_or_gene_productt1interceding-token ngrams: and phosphorylates botht4e2: ents2Label-mention-ngram: corepressor returns totZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: the chromatintke1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt)interceding-token ngrams: SMRT at Ser2410t.interceding-token ngrams: heterodimer binds tot#interceding-token ngrams: chromatint4e2: trigger-arg-path: bound:Binding >nsubj >nn themet,interceding-token ngrams: remains associatedt%interceding-token ngrams: both p65 atte2: args2Role-mention-ngram: NFt)interceding-token ngrams: p65 heterodimert[e1: trigger-arg-path: bound >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt&interceding-token ngrams: p50-RelA andt*interceding-token ngrams: p50-RelA and p65tTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn Gene_or_gene_productt)interceding-token ngrams: active p50-RelAt*e2: ents2Label-mention-ngram: bound NF andt(interceding-token ngrams: the promoter ,tLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn Gene_or_gene_productt,e1: args2Role-mention-ngram: chromatin boundtce2: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt,e1: trigger-arg-path: bound >nsubj >nn themetle1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME corepressort-e1: args2Role-mention-ngram: to the chromatintHe1: trigger-arg-path: bound:Binding >dobj >nn theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: chromatin boundt%e1: args2Role-mention-ngram: bound NFt'e1: ents2Label-mention-ngram: chromatint4interceding-token ngrams: complex almost immediatelytze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: NF and THEMEtke2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt_e2: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt/interceding-token ngrams: immediately after thet1e1: ents2Label-mention-ngram: the chromatin boundt&e1: ents2Label-mention-ngram: bound NFt&e2: ents2Label-mention-ngram: bound NFt-interceding-token ngrams: promoter , IKKalphat3anaphor-basic: args2Role-mention-ngram: associationt/interceding-token ngrams: p65 heterodimer bindstVe1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themet,interceding-token ngrams: Ser2410 to preventt%e2: ents2Label-mention-ngram: returnstne2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt'interceding-token ngrams: p65 at Ser536t#e2: args2Role-mention-ngram: NF andt+e2: ents2Label-mention-ngram: the chromatint!interceding-token ngrams: remainst,e2: trigger-arg-path: bound >nsubj >nn themet3interceding-token ngrams: recruitment and chromatint interceding-token ngrams: p65 att!interceding-token ngrams: Ser2410t,e1: ents2Label-mention-ngram: returns to thetIe2: trigger-arg-path: bound:Binding >nsubj >nn theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Gene_or_gene_productt"interceding-token ngrams: p50-RelAtNe2: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] themet2interceding-token ngrams: almost immediately aftertinterceding-token ngrams: p65tdobj >nn Gene_or_gene_producttVe2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] themet,e2: args2Role-mention-ngram: chromatin boundt=e2: trigger-arg-path: Binding >nsubj >nn Gene_or_gene_producttBe1: trigger-arg-path: Binding >dobj >nn theme:Gene_or_gene_productt%interceding-token ngrams: prevent thet1interceding-token ngrams: prevent the recruitmentt,interceding-token ngrams: , IKKalpha remainst'interceding-token ngrams: at Ser2410 tot-interceding-token ngrams: the active p50-RelAtee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] themetCe2: trigger-arg-path: bound:Binding >nsubj >nn Gene_or_gene_productt:e1: trigger-arg-path: bound >dobj >nn Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_producttee1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_productt!interceding-token ngrams: and p65t$e1: args2Role-mention-ngram: returnst+e1-label: Binding + e2-label: Generic_eventt*interceding-token ngrams: IKKalpha remainstie1: trigger-arg-path: bound:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] theme:Gene_or_gene_productt&interceding-token ngrams: binds to thet!interceding-token ngrams: preventt+interceding-token ngrams: the chromatin andt3e1: args2Role-mention-ngram: corepressor returns tot1e1: ents2Label-mention-ngram: corepressor returnst9e1: ents2Label-mention-ngram: NF and GENE_OR_GENE_PRODUCTt,interceding-token ngrams: almost immediatelyt#interceding-token ngrams: at Ser536t3e2: args2Role-mention-ngram: corepressor returns tot"interceding-token ngrams: binds totSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Gene_or_gene_productt5shortest-path: prep_at >vmod >dobjt$interceding-token ngrams: , IKKalphatte1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='kappab'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='return'] >nn [lemma='smrt'] Gene_or_gene_productt+interceding-token ngrams: immediately aftert,e2: ents2Label-mention-ngram: returns to thet]e1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='kappab'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: a targett]e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:FamilytMe1: trigger-arg-path: target >nsubj [lemma='creb'] theme:Gene_or_gene_productt\e2: trigger-arg-path: activate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_of [lemma='akt'] themet)interceding-token ngrams: mentioned abovetPe2: trigger-arg-path: Positive_activation >nsubj [lemma='tax'] controller:Familytre2: trigger-arg-path: activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='creb'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: is also atSe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='akt'] themetLe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax'] FamilytTtrigger-to-trigger-path: e1:target:Binding >conj_and e2:activate:Positive_activationt)e2: args2Role-mention-ngram: can activatetHe1: trigger-arg-path: target >prep_of [lemma='akt'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='creb'] themetZe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='akt'] Gene_or_gene_producttRe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='tax'] controllertne2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn controlled:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='creb'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='creb'] themet8interceding-tokens-full-span: and , as mentioned above ,t)e2: args2Role-mention-ngram: activate thetYe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='creb'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='akt'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: can activate thet*e1: args2Role-mention-ngram: THEME is alsotPe1: trigger-arg-path: target:Binding >prep_of [lemma='akt'] Gene_or_gene_productt,e2: trigger-arg-path: activate >nsubj Familytfe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax'] controller:Familyt>e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj Familyt@e1: trigger-arg-path: target:Binding >nsubj [lemma='creb'] themetEe2: trigger-arg-path: activate >nsubj [lemma='tax'] controller:FamilytOe1: trigger-arg-path: target:Binding >nsubj [lemma='creb'] Gene_or_gene_producttte2: trigger-arg-path: Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlled:Gene_or_gene_producttGe2: trigger-arg-path: activate:Positive_activation >dobj >nn controlledtke2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax'] controller:Familyt?e2: ents2Label-mention-ngram: activate the GENE_OR_GENE_PRODUCTtIe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Familythe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt(interceding-token ngrams: , as mentionedtAe1: trigger-arg-path: target:Binding >prep_of [lemma='akt'] themetUe1: trigger-arg-path: target:Binding >nsubj [lemma='creb'] theme:Gene_or_gene_productt,interceding-token ngrams: as mentioned abovet-e2: args2Role-mention-ngram: can activate thetYe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn controlledtIe2: trigger-arg-path: Positive_activation >nsubj [lemma='tax'] controllert7e2: trigger-arg-path: activate >nsubj controller:Familyt7e2: trigger-arg-path: Positive_activation >nsubj Familytpe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] Gene_or_gene_producttXshortest-path: conj_and [lemma='activate'] >nsubj [lemma='tax']t(e2: ents2Label-mention-ngram: FAMILY cantRe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj Familyt^e2: trigger-arg-path: activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: a target oft+interceding-token ngrams: mentioned above ,tKe2: trigger-arg-path: activate:Positive_activation >nsubj controller:Familytae1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='creb'] Gene_or_gene_productt"interceding-token ngrams: and , ast{e2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlled:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='akt'] themet`e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax'] Familyt+e1: ents2Label-mention-ngram: also a targett1e2: ents2Label-mention-ngram: FAMILY can activatetinterceding-token ngrams: abovetVe1: trigger-arg-path: target:Binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: also at9e1: trigger-arg-path: target >prep_of [lemma='akt'] themet#interceding-token ngrams: mentionedt>e2: trigger-arg-path: activate >nsubj [lemma='tax'] controllert?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] Gene_or_gene_productt@e2: trigger-arg-path: activate:Positive_activation >nsubj Familyt$e1: args2Role-mention-ngram: is alsotbe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='akt'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlled:Gene_or_gene_productt:e2: trigger-arg-path: activate >nsubj [lemma='tax'] Familytce2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn Gene_or_gene_productt4e2: args2Role-mention-ngram: activate the CONTROLLEDt!interceding-token ngrams: above ,t8e1: trigger-arg-path: target >nsubj [lemma='creb'] themet*e2: ents2Label-mention-ngram: can activatetOe1: trigger-arg-path: Binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='creb'] themet}e2: trigger-arg-path: activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: activate >dobj >nn controlled:Gene_or_gene_producttQe2: trigger-arg-path: activate:Positive_activation >dobj >nn Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax'] controllert(e1: args2Role-mention-ngram: a target oftNe1: trigger-arg-path: Binding >nsubj [lemma='creb'] theme:Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT is alsotinterceding-token ngrams: and ,tNe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='tax'] Familyt4e2: args2Role-mention-ngram: CONTROLLER can activatet=e2: trigger-arg-path: activate >dobj >nn Gene_or_gene_productt%e1: ents2Label-mention-ngram: is alsot#e1: args2Role-mention-ngram: also at5e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ist*e2: ents2Label-mention-ngram: activate thetNe1: trigger-arg-path: target >prep_of [lemma='akt'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn Gene_or_gene_productt3e2: trigger-arg-path: activate >dobj >nn controlledt_e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='creb'] theme:Gene_or_gene_producttie2: trigger-arg-path: activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlled:Gene_or_gene_productthe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlledtde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax'] controllertYe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='tax'] controller:Familyt&interceding-token ngrams: as mentionedtZe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn controlled:Gene_or_gene_producttGe1: trigger-arg-path: target >nsubj [lemma='creb'] Gene_or_gene_producttie2: trigger-arg-path: Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlledtze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlledt%e1: args2Role-mention-ngram: a targettBe2: trigger-arg-path: Positive_activation >nsubj controller:FamilytIe1: trigger-arg-path: Binding >prep_of [lemma='akt'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn controlledtEe2: trigger-arg-path: Positive_activation >nsubj [lemma='tax'] Familytgtrigger-to-trigger-path: e1:target:Binding >conj_and [lemma='activate'] e2:activate:Positive_activationtTe2: trigger-arg-path: activate >dobj [lemma='pathway'] >nn [lemma='pi3k'] controlledt*e1: args2Role-mention-ngram: also a targett&e1: args2Role-mention-ngram: is also at(e2: ents2Label-mention-ngram: , and T163t*e1: args2Role-mention-ngram: THEME at S155t]e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetutrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationtve1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetpe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and T163t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: S159 ,t|e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitetfe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitet?e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_productt^e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetHe1: trigger-arg-path: Binding >nsubj [lemma='gsk3'] Gene_or_gene_producttje1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='gsk3'] themetoe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] SitetCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] themet&e1: args2Role-mention-ngram: at S155 ,t?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_producttae1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitetce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] SitetLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] themette1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_producttne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttze1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttOe2: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] Gene_or_gene_productt^e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitet4e1: args2Role-mention-ngram: with and phosphorylatestte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] Gene_or_gene_producttPe1: trigger-arg-path: interacts >nsubj [lemma='gsk3'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themet$e1: args2Role-mention-ngram: at S155t`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] Gene_or_gene_productt!e1: args2Role-mention-ngram: S155t#e1: args2Role-mention-ngram: S155 ,tRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitet4e1: args2Role-mention-ngram: phosphorylates THEME attVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] controllertEe2: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] controllert]trigger-to-trigger-path: e1:interacts:Binding >conj_and e2:phosphorylates:Positive_regulationt&e2: ents2Label-mention-ngram: , S159 ,t}e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk3'] controllertNe1: trigger-arg-path: Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] themet\e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetle1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] Gene_or_gene_producttZe2: trigger-arg-path: phosphorylates >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttfe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttce1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:SitetXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_producttee1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themet"e2: ents2Label-mention-ngram: T163t[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] Gene_or_gene_productt\e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] Sitetre1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk3'] controllert[e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mcl-1'] themetie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gsk3'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: S159 , andtke1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] site:Sitet;e1: trigger-arg-path: interacts >nsubj [lemma='gsk3'] themetwe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetoe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='s159'] sitetke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk3'] controller:Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='gsk3'] Gene_or_gene_productt(e1: args2Role-mention-ngram: S155 , SITEtae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3'] controllert"interceding-token ngrams: has beent,e2: ents2Label-mention-ngram: SHARED at S338tbe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] controllertinterceding-token ngrams: to betTe1: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_producttse1: trigger-arg-path: mediated >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlledt}e1: trigger-arg-path: mediated >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=phosphorylate ccomp >nsubjpass >nn controlledtHe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:Familyt"interceding-token ngrams: shown totBe1: trigger-arg-path: Positive_activation >nsubj controller:Familyt0interceding-token ngrams: calcium and calmodulint/e2: args2Role-mention-ngram: CONTROLLER ) whicht,e1: trigger-arg-path: mediated >nsubj Familyt?e1: trigger-arg-path: mediated >ccomp >nsubjpass >nn controlledt$interceding-token ngrams: on calciumt"e2: ents2Label-mention-ngram: S338t?e1: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] Gene_or_gene_productt(shortest-path: ccomp >xcomp >dept]e2: trigger-arg-path: phosphorylates nsubj [lemma='ra'] controller:Familyt)interceding-token ngrams: be dependent ontqe2: trigger-arg-path: phosphorylates:Positive_regulation nsubj [lemma='ra'] controllert&interceding-token ngrams: be dependenttde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn controlledtie1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] controller:Familytinterceding-token ngrams: bet?e1: trigger-arg-path: mediated >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] Familytbe2: trigger-arg-path: Positive_regulation nsubj Familytee1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlled:Gene_or_gene_productt$e2: args2Role-mention-ngram: ) whicht.interceding-token ngrams: calmodulin dependentt#interceding-token ngrams: kinase IIt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] Gene_or_gene_producttDe1: trigger-arg-path: mediated:Positive_activation >nsubj controllert2interceding-token ngrams: dependent protein kinasetWe2: trigger-arg-path: Positive_regulation ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlledtDe1: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] Familyt2interceding-token ngrams: and calmodulin dependentt(interceding-token ngrams: on calcium andt(interceding-token ngrams: has been shownt?e1: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlled:Gene_or_gene_productt)interceding-token ngrams: to be dependentt2e2: ents2Label-mention-ngram: which phosphorylatest%e2: ents2Label-mention-ngram: at S338t+interceding-token ngrams: protein kinase IItDe1: trigger-arg-path: mediated >nsubj [lemma='ra'] controller:Familyt?e1: trigger-arg-path: Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: ) which phosphorylatest9e1: trigger-arg-path: mediated >nsubj [lemma='ra'] Familytinterceding-tokens-full-span: activation has been shown to be dependent on calcium and calmodulin dependent protein kinase II (t/e2: args2Role-mention-ngram: ) which CONTROLLEDt!interceding-token ngrams: proteint%interceding-token ngrams: kinase II (tZe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn Gene_or_gene_productt_e1: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn controlled:Gene_or_gene_producttTe1: trigger-arg-path: mediated >ccomp >nsubjpass >nn controlled:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn controlled:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=phosphorylate ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlled:Gene_or_gene_productt7e1: trigger-arg-path: Positive_activation >nsubj Familyt\e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj controller:Familytwe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation ccomp >nsubjpass >nn controlled:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj Familytne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] controllert-interceding-token ngrams: activation has beentMe2: trigger-arg-path: Positive_regulation ccomp [lemma='show'] >xcomp [lemma='dependent'] >dep [lemma='camk-ii'] >rcmod [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationt]e1: trigger-arg-path: mediated:Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_productt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ) whicht?e1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlledt(interceding-token ngrams: protein kinasetXe1: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='ra'] controller:Familyt?e1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] Gene_or_gene_producttRe2: trigger-arg-path: phosphorylates nsubj controllert^e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] Familytxtrigger-to-trigger-path: e1:mediated:Positive_activation >ccomp >xcomp >dep >rcmod e2:phosphorylates:Positive_regulationtoshortest-path: ccomp [lemma='show'] >xcomp [lemma='dependent'] >dep [lemma='camk-ii']tMe1: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='ra'] Familytce2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='ra'] controllert~e1: trigger-arg-path: Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlledt-e1: ents2Label-mention-ngram: FAMILY mediatedt6interceding-token ngrams: calmodulin dependent proteintme2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj controller:Familyt?e1: trigger-arg-path: Positive_activation >ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlled:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn controlledt@e1: trigger-arg-path: mediated:Positive_activation >nsubj FamilytUe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] controller:Familyt4e1: ents2Label-mention-ngram: FAMILY mediated SHAREDt-e2: args2Role-mention-ngram: which CONTROLLEDtIe1: trigger-arg-path: mediated >ccomp >nsubjpass >nn Gene_or_gene_productt&interceding-token ngrams: dependent ontHe2: trigger-arg-path: phosphorylates ccomp [lemma='show'] >nsubjpass [lemma='activation'] >nn [lemma='raf-1'] controlledt%interceding-token ngrams: calcium andtJe1: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn controlledtHe1: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] controllert%e2: ents2Label-mention-ngram: ) whicht$interceding-token ngrams: been shownt(interceding-token ngrams: and calmodulint7e1: trigger-arg-path: mediated >nsubj controller:Familytinterceding-token ngrams: II (t1e1: trigger-arg-path: binds >prep_to theme:FamilytBe1: trigger-arg-path: binds:Binding >nsubj [lemma='beclin1'] themet+interceding-token ngrams: complex ; howevertEe2: ents2Label-mention-ngram: phosphorylation by GENE_OR_GENE_PRODUCTtqe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='kinase'] controller:Gene_or_gene_productt"interceding-token ngrams: levels ,tCe1: trigger-arg-path: Binding >prep_to [lemma='bcl-2'] theme:Familytinterceding-token ngrams: formtKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bcl-2'] themetCe1: trigger-arg-path: binds:Binding >prep_to [lemma='bcl-2'] Familyt?shortest-path: parataxis >xcomp >dobj >prep_such_as >nnt#interceding-token ngrams: activatedt%interceding-token ngrams: ; however ,tTe2: trigger-arg-path: phosphorylation >prep_by [lemma='kinase'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='beclin1'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_to [lemma='bcl-2'] Familyt&interceding-token ngrams: this complext#interceding-token ngrams: ; howevert'interceding-token ngrams: as when Bcl-2t%interceding-token ngrams: dissociatest_e2: trigger-arg-path: phosphorylation >prep_by [lemma='kinase'] controller:Gene_or_gene_productt(interceding-token ngrams: when Bcl-2 wast\e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='kinase'] controllert!interceding-token ngrams: as whentAe1: trigger-arg-path: binds >prep_to [lemma='bcl-2'] theme:Familyt9e1: trigger-arg-path: binds:Binding >prep_to theme:Familyt-interceding-token ngrams: an upstream pathwayt"interceding-token ngrams: increasetvtrigger-to-trigger-path: e1:binds:Binding >parataxis >xcomp >dobj >prep_such_as e2:phosphorylation:Positive_regulationtTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bcl-2'] Familyt2interceding-token ngrams: this complex dissociatest"interceding-token ngrams: upstreamtOe1: trigger-arg-path: binds >nsubj [lemma='beclin1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='kinase'] Gene_or_gene_producttinterceding-token ngrams: whent?interceding-tokens-full-span: to form the Bcl-2 / Beclin 1 complex ; however , this complex dissociates , causing increase autophagy levels , such as when Bcl-2 was activated by an upstream pathway , such ast#interceding-token ngrams: the Bcl-2t)interceding-token ngrams: activated by ant;e1: trigger-arg-path: binds >prep_to [lemma='bcl-2'] Familyt&interceding-token ngrams: activated byt-interceding-token ngrams: Bcl-2 was activatedt/interceding-token ngrams: complex dissociates ,tXe2: trigger-arg-path: Positive_regulation >prep_by [lemma='kinase'] Gene_or_gene_producttJe2: trigger-arg-path: phosphorylation >prep_by [lemma='kinase'] controllert(interceding-token ngrams: by an upstreamt$interceding-token ngrams: / Beclin 1tnsubj [lemma='beclin1'] themet'interceding-token ngrams: was activatedt`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='beclin1'] theme:Gene_or_gene_productt#interceding-token ngrams: autophagyt-interceding-token ngrams: complex dissociatest:e1: trigger-arg-path: binds >nsubj [lemma='beclin1'] themetWe1: trigger-arg-path: binds:Binding >nsubj [lemma='beclin1'] theme:Gene_or_gene_productt(interceding-token ngrams: however , thist*interceding-token ngrams: autophagy levelst;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds tot*interceding-token ngrams: Beclin 1 complext'interceding-token ngrams: dissociates ,t#interceding-token ngrams: pathway ,t'interceding-token ngrams: levels , sucht#interceding-token ngrams: 1 complext?shortest-path: parataxis [lemma='dissociate'] >xcomp [lemma='cause'] >dobj [lemma='level'] >prep_such_as [lemma='phosphorylation'] >nn [lemma='bcl-2']t3interceding-token ngrams: increase autophagy levelstse2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='kinase'] controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='beclin1'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bcl-2'] Familyt!interceding-token ngrams: causingt+e1: trigger-arg-path: binds >prep_to Familyt%interceding-token ngrams: 1 complex ;t$interceding-token ngrams: when Bcl-2tBe1: trigger-arg-path: binds:Binding >prep_to [lemma='bcl-2'] themetSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='beclin1'] themet*interceding-token ngrams: causing increasethe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='kinase'] Gene_or_gene_productt%interceding-token ngrams: to form thetpe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='kinase'] controllert interceding-token ngrams: , sucht(interceding-token ngrams: Bcl-2 / Beclint,interceding-token ngrams: autophagy levels ,t*interceding-token ngrams: upstream pathwayt,interceding-token ngrams: upstream pathway ,t,interceding-token ngrams: , causing increaset#interceding-token ngrams: , causingt:e1: trigger-arg-path: binds >prep_to [lemma='bcl-2'] themet^e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='kinase'] controllertinterceding-token ngrams: Bcl-2tze2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='kinase'] Gene_or_gene_productt(interceding-token ngrams: , this complextZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bcl-2'] theme:Familyt!interceding-token ngrams: Bcl-2 /t!interceding-token ngrams: to formt?trigger-to-trigger-path: e1:binds:Binding >parataxis [lemma='dissociate'] >xcomp [lemma='cause'] >dobj [lemma='level'] >prep_such_as [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtinterceding-token ngrams: sucht?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='kinase'] controller:Gene_or_gene_producttce2: trigger-arg-path: Positive_regulation >prep_by [lemma='kinase'] controller:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >prep_by [lemma='kinase'] controllertinterceding-token ngrams: 1tKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='beclin1'] themet3e1: trigger-arg-path: binds:Binding >prep_to FamilytIe1: trigger-arg-path: binds >nsubj [lemma='beclin1'] Gene_or_gene_productt!interceding-token ngrams: such ast interceding-token ngrams: Beclint,interceding-token ngrams: increase autophagyt(interceding-token ngrams: form the Bcl-2t%interceding-token ngrams: an upstreamt/interceding-token ngrams: dissociates , causingt"interceding-token ngrams: form thet"interceding-token ngrams: / BeclintQe1: trigger-arg-path: binds:Binding >nsubj [lemma='beclin1'] Gene_or_gene_productt#interceding-token ngrams: complex ;tprep_to [lemma='bcl-2'] themetIe1: trigger-arg-path: binds:Binding >prep_to [lemma='bcl-2'] theme:Familyt#interceding-token ngrams: , such asthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='beclin1'] theme:Gene_or_gene_productt%interceding-token ngrams: the Bcl-2 /t4interceding-token ngrams: causing increase autophagytSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bcl-2'] themet"interceding-token ngrams: Beclin 1t&interceding-token ngrams: such as whentKe1: trigger-arg-path: Binding >nsubj [lemma='beclin1'] Gene_or_gene_productt#interceding-token ngrams: Bcl-2 wast(interceding-token ngrams: pathway , suchtQe1: trigger-arg-path: Binding >nsubj [lemma='beclin1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bcl-2'] theme:Familyt*interceding-token ngrams: was activated byt\e1: trigger-arg-path: activation:Positive_activation >nn [lemma='egfr'] Gene_or_gene_productt"interceding-token ngrams: : a. thetXe2: trigger-arg-path: complex:Binding >nn [lemma='egfrviius'] theme:Gene_or_gene_producttYe1: trigger-arg-path: activation >prep_of [lemma='stat3'] controlled:Gene_or_gene_productt#e1: args2Role-mention-ngram: driventNe2: trigger-arg-path: complex:Binding >nn [lemma='stat3'] Gene_or_gene_productt?interceding-tokens-full-span: requires : a. the phosphorylation of EGFRvIII by EFGR , b. the nuclear entrance of EGFRvIII , and b. the formation of ant interceding-token ngrams: EFGR ,t#interceding-token ngrams: EFGR , b.tDe1: trigger-arg-path: activation >prep_of [lemma='stat3'] controlledt=shortest-path: conj_and >dobj >prep_of >nnt9e1: args2Role-mention-ngram: CONTROLLER driven activationtbe1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='stat3'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='stat3'] theme:Gene_or_gene_productt(interceding-token ngrams: b. the nucleart interceding-token ngrams: and b.tUe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfrviius'] themet$interceding-token ngrams: requires :tJe2: trigger-arg-path: complex >nn [lemma='egfrviius'] Gene_or_gene_productt>e1: trigger-arg-path: activation >nn [lemma='egfr'] controllertDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT driven activationtJe2: trigger-arg-path: Binding >nn [lemma='egfrviius'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='egfr'] Gene_or_gene_productt5interceding-token ngrams: phosphorylation of EGFRvIIItHe1: trigger-arg-path: activation >nn [lemma='egfr'] Gene_or_gene_productt!interceding-token ngrams: nucleart$interceding-token ngrams: EGFRvIII ,tNe1: trigger-arg-path: activation >prep_of [lemma='stat3'] Gene_or_gene_producttMe1: trigger-arg-path: Positive_activation >prep_of [lemma='stat3'] controlledtbe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfrviius'] theme:Gene_or_gene_productt%interceding-token ngrams: of EGFRvIIIt.e1: args2Role-mention-ngram: driven activationt!interceding-token ngrams: by EFGRt;e2: trigger-arg-path: complex >nn [lemma='egfrviius'] themet*interceding-token ngrams: EGFRvIII by EFGRt.interceding-token ngrams: the nuclear entrancetLe2: trigger-arg-path: complex >nn [lemma='stat3'] theme:Gene_or_gene_producttinterceding-token ngrams: , b.t%interceding-token ngrams: entrance oft,interceding-token ngrams: phosphorylation oft2e1: ents2Label-mention-ngram: driven activation oftge1: trigger-arg-path: activation:Positive_activation >nn [lemma='egfr'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='stat3'] controlledtke1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='stat3'] controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfrviius'] theme:Gene_or_gene_productt?shortest-path: conj_and [lemma='b.'] >dobj [lemma='formation'] >prep_of [lemma='complex'] >nn [lemma='egfrviius']tde1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='egfr'] controllertRe2: trigger-arg-path: complex:Binding >nn [lemma='egfrviius'] Gene_or_gene_productt%interceding-token ngrams: EGFRvIII byt'interceding-token ngrams: of EGFRvIII ,tMe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfrviius'] themetQe1: trigger-arg-path: Positive_activation >nn [lemma='egfr'] Gene_or_gene_productt%interceding-token ngrams: the nucleartye1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='egfr'] controller:Gene_or_gene_productt(interceding-token ngrams: EGFRvIII , andtbe1: trigger-arg-path: Positive_activation >prep_of [lemma='stat3'] controlled:Gene_or_gene_productt;e2: trigger-arg-path: Binding >nn [lemma='egfrviius'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='stat3'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='stat3'] themet7e2: trigger-arg-path: Binding >nn [lemma='stat3'] themet*interceding-token ngrams: b. the formationt?trigger-to-trigger-path: e1:activation:Positive_activation conj_and [lemma='b.'] >dobj [lemma='formation'] >prep_of [lemma='complex'] e2:complex:BindingtXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='stat3'] Gene_or_gene_productt7e2: trigger-arg-path: complex >nn [lemma='stat3'] themetGe1: trigger-arg-path: Positive_activation >nn [lemma='egfr'] controllertinterceding-token ngrams: : a.t interceding-token ngrams: a. thetIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='stat3'] themet*interceding-token ngrams: nuclear entrancetFe2: trigger-arg-path: complex >nn [lemma='stat3'] Gene_or_gene_productt"interceding-token ngrams: , b. thetinterceding-token ngrams: EFGRtLe2: trigger-arg-path: Binding >nn [lemma='stat3'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='stat3'] controlled:Gene_or_gene_productt1e1: args2Role-mention-ngram: driven activation oftinterceding-token ngrams: b.t.e1: args2Role-mention-ngram: CONTROLLER drivent$interceding-token ngrams: and b. thet`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='stat3'] Gene_or_gene_productt\e1: trigger-arg-path: Positive_activation >nn [lemma='egfr'] controller:Gene_or_gene_producttinterceding-token ngrams: of ant'interceding-token ngrams: the formationtVe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='stat3'] controlledt-interceding-token ngrams: nuclear entrance oft/e1: ents2Label-mention-ngram: driven activationt`e1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='stat3'] Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding >nn [lemma='stat3'] themet$e1: ents2Label-mention-ngram: driventne1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='egfr'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='egfr'] controller:Gene_or_gene_productt'interceding-token ngrams: requires : a.tXe1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='stat3'] controlledtSe1: trigger-arg-path: activation >nn [lemma='egfr'] controller:Gene_or_gene_productt"interceding-token ngrams: , and b.t interceding-token ngrams: b. thet9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT driventWe1: trigger-arg-path: Positive_activation >prep_of [lemma='stat3'] Gene_or_gene_productt"interceding-token ngrams: entrancetPe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='egfr'] controllertPe2: trigger-arg-path: Binding >nn [lemma='egfrviius'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='stat3'] Gene_or_gene_productt&interceding-token ngrams: formation oft.interceding-token ngrams: entrance of EGFRvIIIt(interceding-token ngrams: of EGFRvIII bytte1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='stat3'] Gene_or_gene_producttTe2: trigger-arg-path: complex:Binding >nn [lemma='stat3'] theme:Gene_or_gene_productt-interceding-token ngrams: the phosphorylationt#interceding-token ngrams: by EFGR ,t\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfrviius'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfrviius'] Gene_or_gene_productt"interceding-token ngrams: EGFRvIIItPe2: trigger-arg-path: complex >nn [lemma='egfrviius'] theme:Gene_or_gene_productt*interceding-token ngrams: the formation oftCe2: trigger-arg-path: complex:Binding >nn [lemma='egfrviius'] themetttrigger-to-trigger-path: e1:activation:Positive_activation conj_and >dobj >prep_of e2:complex:Bindingt0interceding-token ngrams: the phosphorylation oftRe1: trigger-arg-path: activation:Positive_activation >nn [lemma='egfr'] controllert)interceding-token ngrams: formation of antinterceding-token ngrams: a.tme1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='stat3'] controlled:Gene_or_gene_productt0interceding-token ngrams: a. the phosphorylationt e2: args2Role-mention-ngram: , atqe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controllertpe1: trigger-arg-path: stimulates >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controller:Simple_chemicalt?e2: trigger-arg-path: mediated nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlled:Positive_regulationt-e2: args2Role-mention-ngram: that is mediatedt.e2: ents2Label-mention-ngram: SHARED treatmentt(e2: ents2Label-mention-ngram: SHARED , atve2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Positive_regulationt\e2: trigger-arg-path: Positive_regulation nsubj >nn controlledt5e1: args2Role-mention-ngram: cells stimulates nucleart.e1: ents2Label-mention-ngram: that is mediatedt#e1: ents2Label-mention-ngram: cellstWe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >nn controller:Simple_chemicalt.e2: ents2Label-mention-ngram: cells stimulatest0e1: ents2Label-mention-ngram: treatment of cellst%e1: ents2Label-mention-ngram: that ist1e1: ents2Label-mention-ngram: of cells stimulatest?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlledtKe2: trigger-arg-path: lemmatizedTrigger=mediate >agent Gene_or_gene_productt"e1: args2Role-mention-ngram: cellstee1: trigger-arg-path: stimulates >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Simple_chemicaltIe2: trigger-arg-path: Positive_regulation >agent [lemma='ATM'] controllert`e1: trigger-arg-path: stimulates >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controllert%e2: ents2Label-mention-ngram: processt;e1: trigger-arg-path: stimulates >nsubj >nn Simple_chemicalt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlled:Positive_regulationt$e2: args2Role-mention-ngram: that ist-e2: ents2Label-mention-ngram: process that ist?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Positive_regulationt!e2: args2Role-mention-ngram: thatt)e1: ents2Label-mention-ngram: of SHARED ,t?e2: trigger-arg-path: mediated nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlledtGe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >nn controllert.e1: ents2Label-mention-ngram: accumulation andtYe2: trigger-arg-path: mediated:Positive_regulation >agent controller:Gene_or_gene_productt>e2: ents2Label-mention-ngram: accumulation and phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controller:Simple_chemicalte2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >nn Positive_regulationt*e1: ents2Label-mention-ngram: accumulationt;e2: trigger-arg-path: Positive_regulation >agent controllertke1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj >nn controller:Simple_chemicaltne1: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Simple_chemicaltie1: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controllertee2: trigger-arg-path: mediated nsubj >nn controlled:Positive_regulationtxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='ATM'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: nuclear accumulationt)e2: args2Role-mention-ngram: process thatte1: trigger: stimulatest(e1: ents2Label-mention-ngram: SHARED , atDe2: trigger-arg-path: mediated:Positive_regulation >agent controllertye2: trigger-arg-path: mediated:Positive_regulation nsubj >nn controlled:Positive_regulationt`e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj >nn Simple_chemicalt0e2: ents2Label-mention-ngram: treatment of cellst0e2: ents2Label-mention-ngram: stimulates nucleart1e1: ents2Label-mention-ngram: SHARED treatment oft)e1: args2Role-mention-ngram: treatment oft\e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='ATM'] Gene_or_gene_producttwtrigger-to-trigger-path: e1:stimulates:Positive_regulation >dobj >prep_of >appos >rcmod e2:mediated:Positive_regulationt.e1: ents2Label-mention-ngram: cells stimulatestOe1: trigger-arg-path: Positive_regulation >nsubj >nn controller:Simple_chemicalt4e1: args2Role-mention-ngram: CONTROLLER treatment oft1e2: ents2Label-mention-ngram: of cells stimulatest&e1: args2Role-mention-ngram: treatmentt0e1: ents2Label-mention-ngram: mediated by SHAREDtUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent controllertZe1: trigger-arg-path: stimulates:Positive_regulation >nsubj >nn controller:Simple_chemicaltSe2: trigger-arg-path: mediated >agent [lemma='ATM'] controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='ATM'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: is mediatedt0e1: args2Role-mention-ngram: of cells stimulatest"e1: ents2Label-mention-ngram: thatt-e1: args2Role-mention-ngram: accumulation andt?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlledtee2: trigger-arg-path: mediated:Positive_regulation nsubj >nn controlledtne2: trigger-arg-path: mediated:Positive_regulation nsubj >nn Positive_regulationt^e2: trigger-arg-path: Positive_regulation >agent [lemma='ATM'] controller:Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Positive_regulationt'e1: ents2Label-mention-ngram: treatmentt1e1: args2Role-mention-ngram: nuclear accumulationt.e1: ents2Label-mention-ngram: SHARED treatmentt-e1: ents2Label-mention-ngram: process that ist%e1: ents2Label-mention-ngram: processt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Positive_regulationt,e2: args2Role-mention-ngram: process that ist6e1: ents2Label-mention-ngram: nuclear accumulation andt:e2: trigger-arg-path: mediated >agent Gene_or_gene_productt%e1: args2Role-mention-ngram: of cellst3e2: args2Role-mention-ngram: mediated by CONTROLLERt$e2: args2Role-mention-ngram: processt&shortest-path: nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent Gene_or_gene_producttZe2: trigger-arg-path: mediated nsubj >nn Positive_regulationt&e1: ents2Label-mention-ngram: of cellst&e2: ents2Label-mention-ngram: of cellstnsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controller:Simple_chemicalt!e1: ents2Label-mention-ngram: , at?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >nn controlled:Positive_regulationt6e2: ents2Label-mention-ngram: nuclear accumulation andt?e1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controller:Simple_chemicaltAe2: trigger-arg-path: lemmatizedTrigger=mediate >agent controllert)e2: ents2Label-mention-ngram: , a processt1e1: args2Role-mention-ngram: CONTROLLER treatmentt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Simple_chemicalt=e2: ents2Label-mention-ngram: stimulates nuclear accumulationt-e1: args2Role-mention-ngram: cells stimulatest1e2: ents2Label-mention-ngram: SHARED treatment oft?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlled:Positive_regulationt&e2: args2Role-mention-ngram: a processt5e1: args2Role-mention-ngram: nuclear accumulation andtEe2: trigger-arg-path: mediated >agent controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: a processt"e2: ents2Label-mention-ngram: thatt=e1: ents2Label-mention-ngram: stimulates nuclear accumulationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlled:Positive_regulationt0e2: ents2Label-mention-ngram: mediated by SHAREDt0e2: trigger-arg-path: mediated >agent controllert?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlled:Positive_regulationtpe2: trigger-arg-path: Positive_regulation nsubj >nn controlled:Positive_regulationt(e1: ents2Label-mention-ngram: stimulateste2: CONTROLLED: 6t%e1: ents2Label-mention-ngram: nucleart$e1: args2Role-mention-ngram: nucleart!e2: ents2Label-mention-ngram: , atye1: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controller:Simple_chemicalt.e2: ents2Label-mention-ngram: that is mediatedtDe1: trigger-arg-path: Positive_regulation >nsubj >nn Simple_chemicalt/e1: args2Role-mention-ngram: stimulates nucleart.e2: ents2Label-mention-ngram: accumulation andtNe2: trigger-arg-path: mediated:Positive_regulation >agent Gene_or_gene_producttOe1: trigger-arg-path: stimulates:Positive_regulation >nsubj >nn Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controllertRe2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='ATM'] controllertde2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='ATM'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: is mediated bytce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='ATM'] controllertVe2: trigger-arg-path: lemmatizedTrigger=mediate >agent controller:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Simple_chemicalt8e1: args2Role-mention-ngram: accumulation and CONTROLLEDt,e1: ents2Label-mention-ngram: a process thatt'e1: args2Role-mention-ngram: stimulatest*e1: ents2Label-mention-ngram: process thatt>e2: trigger-arg-path: mediated >agent [lemma='ATM'] controllert*e1: ents2Label-mention-ngram: treatment oftYe2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='ATM'] Gene_or_gene_producttge2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='ATM'] controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj >nn controllert?trigger-to-trigger-path: e1:stimulates:Positive_regulation >dobj [lemma='accumulation'] >prep_of [lemma='p53'] >appos [lemma='process'] >rcmod [lemma='mediate'] e2:mediated:Positive_regulationt*e2: ents2Label-mention-ngram: process thatt*e2: ents2Label-mention-ngram: treatment oft,e2: ents2Label-mention-ngram: a process thatt)e1: ents2Label-mention-ngram: , a processt+e2: args2Role-mention-ngram: a process thatt?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controlledtve2: trigger-arg-path: lemmatizedTrigger=mediate nsubj >nn controlled:Positive_regulationt(e2: args2Role-mention-ngram: , a processtje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='ATM'] controllertPe2: trigger-arg-path: Positive_regulation >agent controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: a processt6e1: ents2Label-mention-ngram: cells stimulates nucleart?e2: trigger-arg-path: mediated nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] Positive_regulationtee2: trigger-arg-path: Positive_regulation nsubj >nn Positive_regulationt/e1: args2Role-mention-ngram: treatment of cellst0e1: ents2Label-mention-ngram: stimulates nucleartJe1: trigger-arg-path: stimulates:Positive_regulation >nsubj >nn controllertQe2: trigger-arg-path: mediated nsubj >nn controlledt6e1: trigger-arg-path: stimulates >nsubj >nn controllertSe2: trigger-arg-path: Positive_regulation >agent [lemma='ATM'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: mediated bytbe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj >nn controlledt+e2: args2Role-mention-ngram: CONTROLLED , atEe2: trigger-arg-path: Positive_regulation >agent Gene_or_gene_productt)e1: args2Role-mention-ngram: accumulationtHe2: trigger-arg-path: mediated >agent [lemma='ATM'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=mediate nsubj >nn Positive_regulationt%e2: ents2Label-mention-ngram: that ist6e2: ents2Label-mention-ngram: cells stimulates nucleartte1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='treatment'] >nn [lemma='doxorubicin'] controllert>e1: ents2Label-mention-ngram: accumulation and phosphorylationt2e2: ents2Label-mention-ngram: nuclear accumulationtFe1: trigger-arg-path: stimulates >nsubj >nn controller:Simple_chemicaltLe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >nn Simple_chemicalt6e2: trigger-arg-path: complex >nn [lemma='cdk2'] themet?e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj [lemma='p53'] controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] themete1: trigger-arg-path: up-regulate:Positive_regulation nsubj [lemma='p53'] controller:Gene_or_gene_productt>e1: ents2Label-mention-ngram: up-regulate GENE_OR_GENE_PRODUCTtVe1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] Gene_or_gene_producttke1: trigger-arg-path: up-regulate nsubj [lemma='p53'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: the cyclinE andt"e1: ents2Label-mention-ngram: actstje1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj [lemma='p53'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation nsubj [lemma='p53'] controllert/e1: args2Role-mention-ngram: CONTROLLER acts tothe1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj [lemma='p53'] controllert(e1: ents2Label-mention-ngram: which thentce1: trigger-arg-path: up-regulate:Positive_regulation nsubj controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: CONTROLLER actstEe2: trigger-arg-path: complex >nn [lemma='cdk2'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: up-regulate CONTROLLEDtPe2: trigger-arg-path: complex:Binding >nn [lemma='cycline'] Gene_or_gene_productt(e1: args2Role-mention-ngram: up-regulatethe1: trigger-arg-path: Positive_regulation nsubj [lemma='p53'] Gene_or_gene_productt6e1: args2Role-mention-ngram: to up-regulate CONTROLLEDtEe2: trigger-arg-path: Binding >nn [lemma='cdk2'] Gene_or_gene_productt6shortest-path: xcomp >dobj >rcmod >prep_to >nntKe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] themetNe2: trigger-arg-path: Binding >nn [lemma='cycline'] theme:Gene_or_gene_producttWe1: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_productt@e1: ents2Label-mention-ngram: up-regulate GENE_OR_GENE_PRODUCT ,t0e1: args2Role-mention-ngram: acts to up-regulatetVe1: trigger-arg-path: up-regulate nsubj [lemma='p53'] controllertKe2: trigger-arg-path: complex >nn [lemma='cdk2'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:up-regulate:Positive_regulation >dobj [lemma='p21'] >rcmod [lemma='bind'] >prep_to [lemma='complex'] e2:complex:Bindingtee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] theme:Gene_or_gene_producttdtrigger-to-trigger-path: e1:up-regulate:Positive_regulation >dobj >rcmod >prep_to e2:complex:BindingtNe1: trigger-arg-path: up-regulate:Positive_regulation nsubj controllert%e1: ents2Label-mention-ngram: , whichtNe2: trigger-arg-path: complex >nn [lemma='cycline'] theme:Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , whichtSe2: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] theme:Gene_or_gene_producttDe1: trigger-arg-path: up-regulate nsubj Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] themetHe2: trigger-arg-path: complex >nn [lemma='cycline'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj [lemma='p53'] controller:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='cdk2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: up-regulate:Positive_regulation nsubj Gene_or_gene_productt+e1: args2Role-mention-ngram: to up-regulatet0e1: ents2Label-mention-ngram: cyclinE and SHAREDt!e1: args2Role-mention-ngram: actst:e1: trigger-arg-path: up-regulate nsubj controllertBe1: trigger-arg-path: Positive_regulation nsubj controllerte1: trigger: up-regulatetVe2: trigger-arg-path: complex:Binding >nn [lemma='cycline'] theme:Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT acts totZe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: which then bindst$e1: args2Role-mention-ngram: acts tot9e2: trigger-arg-path: complex >nn [lemma='cycline'] themet?shortest-path: xcomp [lemma='up-regulate'] >dobj [lemma='p21'] >rcmod [lemma='bind'] >prep_to [lemma='complex'] >nn [lemma='cycline']tte1: trigger-arg-path: up-regulate:Positive_regulation nsubj [lemma='p53'] Gene_or_gene_producttHe2: trigger-arg-path: Binding >nn [lemma='cycline'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: acts tot9e2: trigger-arg-path: Binding >nn [lemma='cycline'] themetbe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: to the cyclinEt)e1: ents2Label-mention-ngram: the cyclinEt%e1: ents2Label-mention-ngram: cyclinEt>e2: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] themet|e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj [lemma='p53'] controllert6e2: trigger-arg-path: Binding >nn [lemma='cdk2'] themetOe1: trigger-arg-path: up-regulate nsubj controller:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj controllertMe2: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj controller:Gene_or_gene_producttAe2: trigger-arg-path: complex:Binding >nn [lemma='cycline'] themetSe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] themet#e1: ents2Label-mention-ngram: whichtLe1: trigger-arg-path: Positive_regulation nsubj Gene_or_gene_productt*e1: ents2Label-mention-ngram: , which thent)e1: ents2Label-mention-ngram: cyclinE andtse1: trigger-arg-path: Positive_regulation nsubj [lemma='p53'] controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT actstre1: trigger-arg-path: lemmatizedTrigger=up-regulate nsubj [lemma='p53'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: to up-regulatet)e1: ents2Label-mention-ngram: up-regulatet`e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj controllert1e1: ents2Label-mention-ngram: acts to up-regulatet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: binds to thetue1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_regulation nsubj controller:Gene_or_gene_producttje1: trigger-arg-path: up-regulate:Positive_regulation nsubj [lemma='p53'] controllert`e1: trigger-arg-path: up-regulate nsubj [lemma='p53'] Gene_or_gene_producttAe1: ents2Label-mention-ngram: to up-regulate GENE_OR_GENE_PRODUCTtTe2: trigger-arg-path: resulting:Positive_regulation conj_and >dobj controllertTe2: trigger-arg-path: Positive_regulation conj_and >dobj Gene_or_gene_productt^e2: trigger-arg-path: resulting:Positive_regulation conj_and >dobj Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=result conj_and >dobj controllertie2: trigger-arg-path: resulting:Positive_regulation conj_and >dobj controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and >dobj controllert?e2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=result conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertJe2: trigger-arg-path: Positive_regulation conj_and >dobj controllert?e2: trigger-arg-path: Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation conj_and >dobj controller:Gene_or_gene_producttetrigger-to-trigger-path: e1:interacts:Binding >vmod [lemma='result'] e2:resulting:Positive_regulationtwe2: trigger-arg-path: resulting conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllert?e2: trigger-arg-path: resulting:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_producttUe2: trigger-arg-path: resulting conj_and >dobj controller:Gene_or_gene_productt?e2: trigger-arg-path: resulting conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_productt@e2: trigger-arg-path: resulting conj_and >dobj controllert?e2: trigger-arg-path: resulting:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertJe2: trigger-arg-path: resulting conj_and >dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=result conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertTtrigger-to-trigger-path: e1:interacts:Binding >vmod e2:resulting:Positive_regulationt?e2: trigger-arg-path: resulting conj_and [lemma='methylate'] >dobj [lemma='stat3'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=result conj_and >dobj Gene_or_gene_productt?e2: trigger-arg-path: resulting:Positive_regulation conj_and [lemma='methylate'] >dobj [lemma='stat3'] controllertxe2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and >dobj controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=result conj_and >dobj controller:Gene_or_gene_productte2: trigger: resultingt?e2: trigger-arg-path: lemmatizedTrigger=result conj_and [lemma='methylate'] >dobj [lemma='stat3'] controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation conj_and >dobj Gene_or_gene_productt)e2: ents2Label-mention-ngram: SHARED onlytZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] controllert]e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] controllert/e2: ents2Label-mention-ngram: phosphorylates WTt1e2: ents2Label-mention-ngram: only phosphorylatestoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: CONTROLLER onlyt,e1: args2Role-mention-ngram: only CONTROLLEDt'e1: ents2Label-mention-ngram: WT SHAREDtDshortest-path: advmod [lemma='only']tSe2: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] Gene_or_gene_productt,e2: args2Role-mention-ngram: only CONTROLLEDt,e2: args2Role-mention-ngram: CONTROLLER onlytXe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: SHARED only phosphorylatest)e1: ents2Label-mention-ngram: SHARED onlytXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttIe2: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] controllert6e1: ents2Label-mention-ngram: phosphorylates WT SHAREDtNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] controllert^e2: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: only phosphorylates WTt/e1: ents2Label-mention-ngram: phosphorylates WTtxe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_productt e1: ents2Label-mention-ngram: WTtge2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_producttre2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] controllertSe1: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] Gene_or_gene_productt e2: ents2Label-mention-ngram: WTt6e2: ents2Label-mention-ngram: phosphorylates WT SHAREDtge1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] Gene_or_gene_producttce1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: only phosphorylatest^e1: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttshortest-path: advmodtne2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] controllertce2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] Gene_or_gene_productt]e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_productt7e2: args2Role-mention-ngram: CONTROLLER only CONTROLLEDt7e1: args2Role-mention-ngram: CONTROLLER only CONTROLLEDt8e2: ents2Label-mention-ngram: SHARED only phosphorylatest'e2: ents2Label-mention-ngram: WT SHAREDtIe1: trigger-arg-path: phosphorylates >nsubj [lemma='p38gamma'] controllert4e1: ents2Label-mention-ngram: only phosphorylates WTtde1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] Gene_or_gene_producttre1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38gamma'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38gamma'] controllertNe2: trigger-arg-path: binds:Binding >dobj [lemma='dimer'] Gene_or_gene_productt7e2: trigger-arg-path: binds >dobj [lemma='dimer'] themet1e1: ents2Label-mention-ngram: inhibitor of SHAREDtbe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: phosphorylate ant?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of [lemma='kappab'] themetue2: trigger-arg-path: binds:Binding prep_of [lemma='kappab'] themet*e2: args2Role-mention-ngram: THEME , whicht?e2: trigger-arg-path: binds:Binding prep_of [lemma='kappab'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of [lemma='kappab'] Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >dobj [lemma='dimer'] theme:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] controllert~e2: trigger-arg-path: Binding prep_of [lemma='kappab'] Gene_or_gene_producttWe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn Gene_or_gene_productt(shortest-path: dobj >prep_oft?trigger-to-trigger-path: e1:phosphorylate:Positive_regulation >dobj [lemma='inhibitor'] >dep [lemma='protein'] >rcmod [lemma='bind'] e2:binds:Bindingt$e2: args2Role-mention-ngram: THEME ,tCe1: trigger-arg-path: phosphorylate >nsubj >nn Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn controller:Gene_or_gene_productt8e1: ents2Label-mention-ngram: complexes phosphorylate antde2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of theme:Gene_or_gene_producttne1: trigger-arg-path: phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] controller:Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding prep_of [lemma='kappab'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind prep_of [lemma='kappab'] Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding prep_of themet\e2: trigger-arg-path: lemmatizedTrigger=bind prep_of theme:Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding prep_of Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controllert?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of [lemma='kappab'] theme:Gene_or_gene_productt>e2: ents2Label-mention-ngram: which binds GENE_OR_GENE_PRODUCTte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controllertme2: trigger-arg-path: binds prep_of [lemma='kappab'] themet~e2: trigger-arg-path: lemmatizedTrigger=bind prep_of [lemma='kappab'] themetdobj [lemma='dimer'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='dimer'] Gene_or_gene_productt|e2: trigger-arg-path: binds prep_of [lemma='kappab'] Gene_or_gene_producttte1: trigger-arg-path: Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controller:Gene_or_gene_producttwe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: complexes phosphorylatet-e1: ents2Label-mention-ngram: an inhibitor oftOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of themetHe2: trigger-arg-path: Binding >dobj [lemma='dimer'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] controllert`trigger-to-trigger-path: e1:phosphorylate:Positive_regulation >dobj >dep >rcmod e2:binds:Bindingt8e2: trigger-arg-path: Binding prep_of themet'e1: ents2Label-mention-ngram: inhibitort*e1: ents2Label-mention-ngram: inhibitor oftMe2: trigger-arg-path: Binding prep_of theme:Gene_or_gene_producttoe2: trigger-arg-path: Binding prep_of [lemma='kappab'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind prep_of [lemma='kappab'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind prep_of themet_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn controllertFe2: trigger-arg-path: binds >dobj [lemma='dimer'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >dobj [lemma='dimer'] theme:Gene_or_gene_producttJe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT complexes phosphorylatet&e1: args2Role-mention-ngram: complexestPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='dimer'] themetUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding >dobj [lemma='dimer'] themetEe2: trigger-arg-path: binds prep_of Gene_or_gene_productt9e2: trigger-arg-path: Binding >dobj [lemma='dimer'] themet6e2: trigger-arg-path: binds prep_of themetMe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn controllertwshortest-path: dobj [lemma='inhibitor'] >prep_of [lemma='kappab']tWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='dimer'] Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_of [lemma='kappab'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn controllertie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn Gene_or_gene_producttGe2: trigger-arg-path: Binding prep_of Gene_or_gene_productt?e2: trigger-arg-path: binds prep_of [lemma='kappab'] theme:Gene_or_gene_producttme1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controllertSe2: trigger-arg-path: binds:Binding prep_of theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controller:Gene_or_gene_productt9e1: trigger-arg-path: phosphorylate >nsubj >nn controllertee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='dimer'] theme:Gene_or_gene_producttnsubj >nn controller:Gene_or_gene_producttKe2: trigger-arg-path: binds prep_of theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] Gene_or_gene_productt?e1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER complexest^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_of Gene_or_gene_productt'e1: ents2Label-mention-ngram: complexest*e1: ents2Label-mention-ngram: an inhibitortVe2: trigger-arg-path: lemmatizedTrigger=bind prep_of Gene_or_gene_productt.e2: args2Role-mention-ngram: which binds THEMEt1e1: args2Role-mention-ngram: complexes CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] Gene_or_gene_producttce1: trigger-arg-path: phosphorylate >nsubj [lemma='complex'] >nn [lemma='ikk'] Gene_or_gene_producttie1: trigger-arg-path: Positive_regulation >nsubj [lemma='complex'] >nn [lemma='ikk'] Gene_or_gene_producttLe2: trigger-arg-path: binds >dobj [lemma='dimer'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: phosphorylate an inhibitortHe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='dimer'] themetJe2: trigger-arg-path: binding >prep_of [lemma='glus'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: and activation oftIe2: trigger-arg-path: binding >prep_of [lemma='jun'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] themetCe2: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] themet/e2: args2Role-mention-ngram: of activated THEMEt*interceding-token ngrams: the EGFR cascadet?shortest-path: ccomp [lemma='event'] >prep_at [lemma='end'] >dep [lemma='induce'] >dobj [lemma='binding']t!interceding-token ngrams: cascadet&interceding-token ngrams: the terminaltIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] controllert interceding-token ngrams: at thet"interceding-token ngrams: the EGFRtRe1: trigger-arg-path: induced >nsubj [lemma='erk'] controller:Gene_or_gene_productt&interceding-token ngrams: the criticaltXe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erk'] Gene_or_gene_producttBe2: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] themet)interceding-token ngrams: is the criticaltUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] themetnsubj [lemma='erk'] controllert+interceding-token ngrams: critical event att+interceding-token ngrams: AP1 transcriptiont(interceding-token ngrams: critical eventt"interceding-token ngrams: event attIe2: trigger-arg-path: Binding >prep_of [lemma='jun'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] Gene_or_gene_producttPe2: trigger-arg-path: binding >prep_of [lemma='glus'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: activation of thetbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='erk'] controllert interceding-token ngrams: is thet$interceding-token ngrams: end of thet;e2: trigger-arg-path: binding >prep_of [lemma='glus'] themet interceding-token ngrams: end oftinterceding-token ngrams: endtde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] Gene_or_gene_productt1interceding-token ngrams: transcription factor istQe2: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: activated SHARED andt:e2: trigger-arg-path: binding >prep_of [lemma='jun'] themetMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] themetMe1: trigger-arg-path: induced:Positive_regulation >nsubj Gene_or_gene_productt%interceding-token ngrams: of the EGFRt1e2: args2Role-mention-ngram: binding of activatedt&interceding-token ngrams: terminal endt#interceding-token ngrams: factor istWe2: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttJe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced phosphorylationt.interceding-token ngrams: transcription factort2e2: ents2Label-mention-ngram: binding of activatedt0shortest-path: ccomp >prep_at >dep >dobjt)interceding-token ngrams: terminal end oft?trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp [lemma='event'] >prep_at [lemma='end'] >dep [lemma='induce'] >dobj [lemma='binding'] e2:binding:Bindingt*interceding-token ngrams: the terminal endt)interceding-token ngrams: at the terminalt?interceding-tokens-full-span: and AP1 transcription factor is the critical event at the terminal end of the EGFR cascade , inducingt/interceding-token ngrams: and AP1 transcriptiont0e2: args2Role-mention-ngram: activated THEME andtle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt&interceding-token ngrams: event at thetRe2: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_of [lemma='glus'] Gene_or_gene_productt2interceding-token ngrams: AP1 transcription factort$interceding-token ngrams: , inducingtfe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttetrigger-to-trigger-path: e1:induced:Positive_regulation >ccomp >prep_at >dep >dobj e2:binding:Bindingt=e1: trigger-arg-path: induced >nsubj [lemma='erk'] controllertXe2: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: of activatedtTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] themetce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erk'] controller:Gene_or_gene_producttinterceding-token ngrams: AP1t:e2: trigger-arg-path: Binding >prep_of [lemma='jun'] themetPe2: trigger-arg-path: Binding >prep_of [lemma='glus'] theme:Gene_or_gene_productt"interceding-token ngrams: terminaltNe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erk'] controllert,e1: ents2Label-mention-ngram: and activationtOe2: trigger-arg-path: Binding >prep_of [lemma='jun'] theme:Gene_or_gene_productt!interceding-token ngrams: and AP1t;e2: trigger-arg-path: Binding >prep_of [lemma='glus'] themet\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_productt"interceding-token ngrams: criticalt"interceding-token ngrams: inducingt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttinterceding-token ngrams: eventt[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] Gene_or_gene_productt,interceding-token ngrams: the critical eventt1e2: ents2Label-mention-ngram: of activated SHAREDtSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_producttGe1: trigger-arg-path: induced >nsubj [lemma='erk'] Gene_or_gene_productt[e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt)e2: args2Role-mention-ngram: of activatedtXe1: trigger-arg-path: induced:Positive_regulation >nsubj controller:Gene_or_gene_productt(interceding-token ngrams: EGFR cascade ,tje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] theme:Gene_or_gene_productt'interceding-token ngrams: factor is thet#interceding-token ngrams: cascade ,t9e1: ents2Label-mention-ngram: induced phosphorylation andtae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttOe2: trigger-arg-path: binding >prep_of [lemma='jun'] theme:Gene_or_gene_productt&interceding-token ngrams: EGFR cascadet,interceding-token ngrams: cascade , inducingt[e2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='p38gamma'] controllertRe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='pfd'] controllertpe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='p38gamma'] controller:Gene_or_gene_productt\e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='pfd'] Gene_or_gene_productt`e2: trigger-arg-path: Positive_regulation >nn [lemma='p38gamma'] controller:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='p38gamma'] Gene_or_gene_producttSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='pfd'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_regulation >nn [lemma='p38gamma'] controllertYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pfd'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='p38gamma'] controller:Gene_or_gene_producttGe2: trigger-arg-path: phosphorylation >nn [lemma='p38gamma'] controllerttrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtshortest-path: dobj >nntIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='pfd'] controllertee2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='p38gamma'] Gene_or_gene_producttSe1: trigger-arg-path: inhibits >nsubj [lemma='pfd'] controller:Gene_or_gene_productt^shortest-path: dobj [lemma='phosphorylation'] >nn [lemma='p38gamma']tUe2: trigger-arg-path: Positive_regulation >nn [lemma='p38gamma'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pfd'] controllertHe1: trigger-arg-path: inhibits >nsubj [lemma='pfd'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: SHARED phosphorylation oft>e1: trigger-arg-path: inhibits >nsubj [lemma='pfd'] controllertYe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='p38gamma'] controllert\e2: trigger-arg-path: phosphorylation >nn [lemma='p38gamma'] controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pfd'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED phosphorylation oftetrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj e2:phosphorylation:Positive_regulationtme2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='p38gamma'] controllertQe2: trigger-arg-path: phosphorylation >nn [lemma='p38gamma'] Gene_or_gene_producttYe1: trigger-arg-path: inhibits:Negative_regulation >nsubj controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pfd'] controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pfd'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='p38gamma'] Gene_or_gene_producttBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibits SHAREDtne2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='p38gamma'] controller:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pfd'] controllertNe1: trigger-arg-path: inhibits:Negative_regulation >nsubj Gene_or_gene_productt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='pfd'] controller:Gene_or_gene_producttge1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='pfd'] controller:Gene_or_gene_productt(interceding-token ngrams: activity , andt5e2: trigger-arg-path: Binding >nn [lemma='p53'] themetVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='mdm2'] Gene_or_gene_productt$interceding-token ngrams: and blockstXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mdm2'] themetGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p53'] themetDe2: trigger-arg-path: complex >nn [lemma='p53'] Gene_or_gene_productt+interceding-token ngrams: ligase activity ,tPe1: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] theme:Generic_entitytAe1: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] themet5e2: trigger-arg-path: complex >nn [lemma='p53'] themet interceding-token ngrams: blockst9interceding-token ngrams: the nucleocytoplasmic shuttlingt5interceding-token ngrams: nucleocytoplasmic shuttlingtBe1: trigger-arg-path: interacts >nsubj [lemma='it'] Generic_entitytSe2: trigger-arg-path: complex:Binding >nn [lemma='mdm2'] theme:Gene_or_gene_producttmtrigger-to-trigger-path: e1:interacts:Binding nsubj dobj >prep_of e2:complex:BindingtFe1: trigger-arg-path: Binding >nsubj [lemma='it'] theme:Generic_entitytTe1: trigger-arg-path: interacts >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt=e1: trigger-arg-path: interacts:Binding >nsubj Generic_entityt5e1: trigger-arg-path: interacts >nsubj Generic_entitytNe1: trigger-arg-path: interacts >prep_with [lemma='mdm2'] Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='p53'] Gene_or_gene_productt&interceding-token ngrams: inhibits itst;e1: trigger-arg-path: interacts >nsubj theme:Generic_entityt}interceding-tokens-full-span: , inhibits its E3 ubiquitin ligase activity , and blocks the nucleocytoplasmic shuttling of thet)interceding-token ngrams: ligase activitytKe2: trigger-arg-path: complex >nn [lemma='mdm2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mdm2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: interacts >nsubj [lemma='it'] theme:Generic_entitytHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mdm2'] themetMe2: trigger-arg-path: complex:Binding >nn [lemma='mdm2'] Gene_or_gene_productt7e1: trigger-arg-path: Binding >nsubj [lemma='it'] themetVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p53'] Gene_or_gene_productt$interceding-token ngrams: activity ,t*interceding-token ngrams: ubiquitin ligaset(interceding-token ngrams: and blocks thet3interceding-token ngrams: ubiquitin ligase activityt@e1: trigger-arg-path: Binding >nsubj [lemma='it'] Generic_entitytLe2: trigger-arg-path: complex:Binding >nn [lemma='p53'] Gene_or_gene_productt)interceding-token ngrams: inhibits its E3t&interceding-token ngrams: E3 ubiquitint?trigger-to-trigger-path: e1:interacts:Binding nsubj [lemma='arf'] dobj [lemma='shuttling'] >prep_of [lemma='complex'] e2:complex:Bindingt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p53'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p53'] theme:Gene_or_gene_productt#interceding-token ngrams: shuttlingt?e1: trigger-arg-path: interacts >prep_with [lemma='mdm2'] themet$interceding-token ngrams: , inhibitstEe2: trigger-arg-path: complex >nn [lemma='mdm2'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='mdm2'] themetKe2: trigger-arg-path: Binding >nn [lemma='mdm2'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mdm2'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='p53'] theme:Gene_or_gene_productt interceding-token ngrams: its E3tJe2: trigger-arg-path: complex >nn [lemma='p53'] theme:Gene_or_gene_productt6interceding-token ngrams: blocks the nucleocytoplasmictme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='mdm2'] themet+interceding-token ngrams: nucleocytoplasmict6e1: ents2Label-mention-ngram: GENERIC_ENTITY interactst$interceding-token ngrams: blocks thetinterceding-token ngrams: E3tFshortest-path: nsubj dobj >prep_of >nnt9e1: trigger-arg-path: Binding >nsubj theme:Generic_entityt&interceding-token ngrams: , and blockstFe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj Generic_entityt=e2: trigger-arg-path: complex:Binding >nn [lemma='p53'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p53'] Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj theme:Generic_entityt interceding-token ngrams: ligaset?shortest-path: nsubj [lemma='arf'] dobj [lemma='shuttling'] >prep_of [lemma='complex'] >nn [lemma='mdm2']t9e1: trigger-arg-path: interacts >nsubj [lemma='it'] themet"interceding-token ngrams: inhibitstae1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] theme:Generic_entitytLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj theme:Generic_entityt-interceding-token ngrams: E3 ubiquitin ligaset_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mdm2'] Gene_or_gene_productt&interceding-token ngrams: shuttling oftWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mdm2'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj Generic_entitytOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p53'] themetJe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] themet8interceding-token ngrams: nucleocytoplasmic shuttling oft(interceding-token ngrams: , inhibits itst3e1: trigger-arg-path: Binding >nsubj Generic_entityt[e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] Generic_entitytRe2: trigger-arg-path: complex:Binding >nn [lemma='p53'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mdm2'] theme:Gene_or_gene_productt#interceding-token ngrams: ubiquitint\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] theme:Generic_entitytGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='mdm2'] themetEe2: trigger-arg-path: Binding >nn [lemma='mdm2'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='it'] Generic_entityt*interceding-token ngrams: shuttling of thet*interceding-token ngrams: its E3 ubiquitint6e2: trigger-arg-path: complex >nn [lemma='mdm2'] themetPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mdm2'] themetJe1: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] Generic_entityt/interceding-token ngrams: the nucleocytoplasmictPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mdm2'] themetRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='it'] themetTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj theme:Generic_entityt;e1: ents2Label-mention-ngram: GENERIC_ENTITY interacts witht_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mdm2'] Gene_or_gene_producttsortest-path-dist: 8tee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mdm2'] theme:Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn FamilytIe1: trigger-arg-path: decreased:Negative_regulation >nsubj >nn controllertke1: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllertnsubj >nn controller:FamilytXe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='gsk-3'] controllertZe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn controllert;e1: args2Role-mention-ngram: signaling decreased CONTROLLEDt.e1: ents2Label-mention-ngram: FAMILY signalingt8e1: ents2Label-mention-ngram: FAMILY signaling decreasedtre1: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt#shortest-path: dobj >nnt1e1: ents2Label-mention-ngram: signaling decreasedtWe1: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllert`e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='gsk-3'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: decreasedtae1: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllertxe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familyt;e1: args2Role-mention-ngram: CONTROLLER signaling decreasedtSe1: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] FamilytPe1: trigger-arg-path: decreased:Negative_regulation >nsubj >nn controller:Familyt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:FamilytMe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn controller:Familyt.e1: ents2Label-mention-ngram: decreased SHAREDtYe2: trigger-arg-path: phosphorylation >nn [lemma='gsk-3'] controller:Gene_or_gene_productttshortest-path: dobj [lemma='phosphorylation'] >nn [lemma='gsk-3']te2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='gsk-3'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: decreased CONTROLLEDtje2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='gsk-3'] controllertDe2: trigger-arg-path: phosphorylation >nn [lemma='gsk-3'] controllertde1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familytbe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='gsk-3'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn controllertNe2: trigger-arg-path: phosphorylation >nn [lemma='gsk-3'] Gene_or_gene_productt0e1: args2Role-mention-ngram: signaling decreasedt?trigger-to-trigger-path: e1:decreased:Negative_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtae1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn controller:FamilytVe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn Familythe1: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt;e1: trigger-arg-path: Negative_regulation >nsubj >nn Familyte1: trigger: decreasedtme2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='gsk-3'] controller:Gene_or_gene_productt]e2: trigger-arg-path: Positive_regulation >nn [lemma='gsk-3'] controller:Gene_or_gene_productt8e1: ents2Label-mention-ngram: signaling decreased SHAREDt5e1: trigger-arg-path: decreased >nsubj >nn controllertEe1: trigger-arg-path: decreased:Negative_regulation >nsubj >nn FamilytFe1: trigger-arg-path: Negative_regulation >nsubj >nn controller:Familytftrigger-to-trigger-path: e1:decreased:Negative_regulation >dobj e2:phosphorylation:Positive_regulationtke2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='gsk-3'] controller:Gene_or_gene_productt>e1: ents2Label-mention-ngram: decreased SHARED phosphorylationtoe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt&e1: args2Role-mention-ngram: decreasedt^e1: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:FamilytVe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='gsk-3'] controllert]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familytte2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='gsk-3'] Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllerthe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllert1e1: trigger-arg-path: decreased >nsubj >nn Familytge1: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] FamilytRe2: trigger-arg-path: Positive_regulation >nn [lemma='gsk-3'] Gene_or_gene_producttHe2: trigger-arg-path: Positive_regulation >nn [lemma='gsk-3'] controllertde2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:Simple_chemicaltYshortest-path: ccomp [lemma='induce'] >nsubj [lemma='arsenite']tHe2: trigger-arg-path: induced:Positive_regulation >nsubj Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='arsenite'] Simple_chemicaltPe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Simple_chemicaltSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='arsenite'] Simple_chemicaltRe2: trigger-arg-path: induced >nsubj [lemma='arsenite'] controller:Simple_chemicalt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='p27'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Simple_chemicaltYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p27'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='arsenite'] controllertSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='p27'] Gene_or_gene_producttSe2: trigger-arg-path: induced:Positive_regulation >nsubj controller:Simple_chemicaltce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='arsenite'] controller:Simple_chemicalthe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='p27'] controller:Gene_or_gene_producttTe1: trigger-arg-path: inhibited >nsubj [lemma='p27'] controller:Gene_or_gene_producttVe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='arsenite'] controllertOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p27'] controllertSe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='arsenite'] controllertIe1: trigger-arg-path: inhibited >nsubj [lemma='p27'] Gene_or_gene_productt4e2: trigger-arg-path: induced >nsubj Simple_chemicaltwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='arsenite'] controller:Simple_chemicalt?e1: trigger-arg-path: inhibited >nsubj [lemma='p27'] controllert[e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='arsenite'] Simple_chemicaltfe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='arsenite'] controller:Simple_chemicalt?e2: trigger-arg-path: induced >nsubj controller:Simple_chemicaltNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='arsenite'] controllertKe2: trigger-arg-path: Positive_regulation >nsubj controller:Simple_chemicaltEe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj Simple_chemicaltnsubj [lemma='arsenite'] controllertGe2: trigger-arg-path: induced >nsubj [lemma='arsenite'] Simple_chemicaltme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p27'] Gene_or_gene_productt]e1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='p27'] Gene_or_gene_producttSe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='p27'] controllert^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='arsenite'] controller:Simple_chemicaltde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p27'] controller:Gene_or_gene_producttIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='p27'] controllertXe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='arsenite'] Simple_chemicalt@e2: trigger-arg-path: Positive_regulation >nsubj Simple_chemicaltce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p27'] controllertxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p27'] controller:Gene_or_gene_productt,interceding-token ngrams: and bladder cancertNe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj [lemma='ra'] FamilytHe1: trigger-arg-path: up-regulates >nsubj [lemma='ra'] controller:Familyt(interceding-token ngrams: bladder cancertle2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj [lemma='ra'] controller:Familyt1e1: ents2Label-mention-ngram: up-regulates SHAREDt'e2: args2Role-mention-ngram: THEME witht;e1: trigger-arg-path: up-regulates >nsubj controller:Familyt^e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_with theme:Gene_or_gene_productt.interceding-token ngrams: mouse fibroblast 7-4t*e2: args2Role-mention-ngram: of THEME witht=e2: trigger-arg-path: binding >prep_of [lemma='rbap46'] themetfe2: trigger-arg-path: binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] Gene_or_gene_producttHe1: trigger-arg-path: up-regulates:Positive_activation >nsubj controllertDe1: trigger-arg-path: up-regulates:Positive_activation >nsubj Familyt)interceding-token ngrams: in human breastt\e1: trigger-arg-path: up-regulates:Positive_activation >nsubj [lemma='ra'] controller:Familyt^e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj [lemma='ra'] FamilytOe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] themetfe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj >nn Gene_or_gene_producttinterceding-token ngrams: humantde1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlledtLe1: trigger-arg-path: up-regulates >dobj >nn controlled:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_with Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj >nn controlledtWe2: trigger-arg-path: binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] themet?e1: args2Role-mention-ngram: CONTROLLER up-regulates CONTROLLEDtgtrigger-to-trigger-path: e1:up-regulates:Positive_activation conj_and >nsubj e2:binding:Bindingt?trigger-to-trigger-path: e1:up-regulates:Positive_activation conj_and [lemma='repress'] >nsubj [lemma='binding'] e2:binding:Bindingt>e2: ents2Label-mention-ngram: SHARED with GENE_OR_GENE_PRODUCTtre1: trigger-arg-path: up-regulates >dobj [lemma='expression'] >nn [lemma='rbap46'] controlled:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj [lemma='ra'] controllert`e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj controller:Familytqe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] themet$interceding-token ngrams: well as int?e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlledt-interceding-token ngrams: expression in humant?interceding-tokens-full-span: expression in human breast and bladder cancer cells as well as in mouse fibroblast 7-4 cells , and thet%interceding-token ngrams: 7-4 cells ,tNe2: trigger-arg-path: binding:Binding >prep_of >prep_with Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_with themet]e1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj >nn controlled:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt.interceding-token ngrams: bladder cancer cellst*interceding-token ngrams: mouse fibroblasttxshortest-path: conj_and [lemma='repress'] >nsubj [lemma='binding']t0e1: trigger-arg-path: up-regulates >nsubj Familyt interceding-token ngrams: breastt'interceding-token ngrams: cells as welltUe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj Familyt]e1: trigger-arg-path: up-regulates >dobj [lemma='expression'] >nn [lemma='rbap46'] controlledtinterceding-token ngrams: mouset_e2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] themet,e2: ents2Label-mention-ngram: of SHARED withtZe2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binding >prep_of [lemma='rbap46'] theme:Gene_or_gene_producttUe1: trigger-arg-path: up-regulates:Positive_activation >dobj >nn Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj [lemma='expression'] >nn [lemma='rbap46'] controlledt"interceding-token ngrams: cells astEe2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] themetQe1: trigger-arg-path: up-regulates:Positive_activation >nsubj [lemma='ra'] Familyt4e1: args2Role-mention-ngram: CONTROLLER up-regulatest.interceding-token ngrams: fibroblast 7-4 cellst*interceding-token ngrams: human breast andt)e1: args2Role-mention-ngram: up-regulatest!interceding-token ngrams: bladdert?e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlled:Gene_or_gene_productt7e2: trigger-arg-path: binding >prep_of >prep_with themetWe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] themetXe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_with Gene_or_gene_productt1e1: ents2Label-mention-ngram: FAMILY up-regulatest%interceding-token ngrams: cells , andtAe1: trigger-arg-path: up-regulates >nsubj [lemma='ra'] controllertQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_with themetxe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] Gene_or_gene_producttle2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] theme:Gene_or_gene_productt7e1: trigger-arg-path: up-regulates >dobj >nn controlledt-e2: args2Role-mention-ngram: THEME with THEMEt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] theme:Gene_or_gene_producttne2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] Gene_or_gene_productt%interceding-token ngrams: as in mousetinterceding-token ngrams: as intLe2: trigger-arg-path: Binding >prep_of >prep_with theme:Gene_or_gene_productte1: trigger: up-regulatestRe1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj >nn Gene_or_gene_productt#interceding-token ngrams: , and thetLe2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: SHARED withtYe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj controllertie2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] themetTe2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] Gene_or_gene_producttTe2: trigger-arg-path: binding:Binding >prep_of >prep_with theme:Gene_or_gene_productt?e1: trigger-arg-path: up-regulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlled:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] themet~e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >nsubj [lemma='ra'] controllertqe1: trigger-arg-path: up-regulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj [lemma='ra'] controller:Familyt%interceding-token ngrams: and bladdert,interceding-token ngrams: breast and bladdert=e1: trigger-arg-path: up-regulates >nsubj [lemma='ra'] FamilytKe1: trigger-arg-path: up-regulates:Positive_activation >dobj >nn controlledtFe2: trigger-arg-path: binding >prep_of >prep_with Gene_or_gene_producttLe2: trigger-arg-path: binding >prep_of [lemma='rbap46'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj controller:Familyt4e1: trigger-arg-path: up-regulates >nsubj controllert$interceding-token ngrams: fibroblasttWe2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] themet#interceding-token ngrams: 7-4 cellstFe2: trigger-arg-path: Binding >prep_of >prep_with Gene_or_gene_producttLe2: trigger-arg-path: binding >prep_of >prep_with theme:Gene_or_gene_producttinterceding-token ngrams: 7-4t?e2: trigger-arg-path: binding:Binding >prep_of >prep_with themette2: trigger-arg-path: binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] theme:Gene_or_gene_productt"interceding-token ngrams: in humantge1: trigger-arg-path: up-regulates >dobj [lemma='expression'] >nn [lemma='rbap46'] Gene_or_gene_productt$interceding-token ngrams: breast andt`e1: trigger-arg-path: up-regulates:Positive_activation >dobj >nn controlled:Gene_or_gene_productt'interceding-token ngrams: expression int"interceding-token ngrams: in mouset?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=up-regulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] Gene_or_gene_producttfe2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] Gene_or_gene_productt{e1: trigger-arg-path: up-regulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] Gene_or_gene_productt(interceding-token ngrams: fibroblast 7-4t*e1: ents2Label-mention-ngram: up-regulatestxe1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj [lemma='expression'] >nn [lemma='rbap46'] Gene_or_gene_productt-shortest-path: conj_and >nsubjtUe1: trigger-arg-path: up-regulates:Positive_activation >nsubj [lemma='ra'] controllert-interceding-token ngrams: in mouse fibroblasttAe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj FamilytOe1: trigger-arg-path: up-regulates:Positive_activation >nsubj controller:Familyt4e1: args2Role-mention-ngram: up-regulates CONTROLLEDtAe1: trigger-arg-path: up-regulates >dobj >nn Gene_or_gene_productt$interceding-token ngrams: expressiont&interceding-token ngrams: human breasttne1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=up-regulate >dobj [lemma='expression'] >nn [lemma='rbap46'] controlled:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_with theme:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=up-regulate >nsubj controllertfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='rbap46'] Gene_or_gene_productt7e2: trigger-arg-path: Binding >prep_of >prep_with themet)interceding-token ngrams: cancer cells astle2: trigger-arg-path: binding >prep_of [lemma='rbap46'] >prep_with [lemma='hdac'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_of [lemma='rbap46'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: FAMILY up-regulates SHAREDtye1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='rbap46'] controlled:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='rbap46'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: binding of thetle1: trigger-arg-path: involves:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlledt,e2: ents2Label-mention-ngram: binding of thetRe2: trigger-arg-path: binding:Binding >prep_of [lemma='pi3k'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt\e1: trigger-arg-path: involves:Positive_regulation >dobj >prep_of controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controller:Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding >prep_of [lemma='pi3k'] themetctrigger-to-trigger-path: e1:involves:Positive_regulation >dobj [lemma='binding'] e2:binding:Bindingtne1: trigger-arg-path: lemmatizedTrigger=involve >dobj [lemma='binding'] >prep_of [lemma='akt'] Phosphorylationtse1: trigger-arg-path: Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlled:Phosphorylationt=e1: trigger-arg-path: involves >nsubj >prep_of >nn controllert1e1: ents2Label-mention-ngram: expression involvestwe1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: involves bindingt:e2: trigger-arg-path: binding >prep_of [lemma='akt'] themet*e2: args2Role-mention-ngram: the THEME andt8e1: trigger-arg-path: involves >dobj >prep_of controlledthe1: trigger-arg-path: Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] Phosphorylationt[e1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_producttOe2: trigger-arg-path: binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: PI3Kt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlled:PhosphorylationtQtrigger-to-trigger-path: e1:involves:Positive_regulation >dobj e2:binding:Bindingtae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controllert;e1: args2Role-mention-ngram: CONTROLLER expression involvestQe1: trigger-arg-path: involves:Positive_regulation >dobj >prep_of PhosphorylationtPe2: trigger-arg-path: binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlledtIe2: trigger-arg-path: binding >prep_of [lemma='akt'] Gene_or_gene_producttfe1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] themet?e1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='akt'] Gene_or_gene_productt+e1: args2Role-mention-ngram: binding of thetNe1: trigger-arg-path: lemmatizedTrigger=involve >dobj >prep_of Phosphorylationt;e2: trigger-arg-path: binding >prep_of [lemma='pi3k'] themetbe1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj >prep_of Phosphorylationt)e1: args2Role-mention-ngram: the PI3K andt?e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controller:Gene_or_gene_producttqe1: trigger-arg-path: involves:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] Phosphorylationt%e1: args2Role-mention-ngram: the PI3KtTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='akt'] themetie1: trigger-arg-path: lemmatizedTrigger=involve >dobj [lemma='binding'] >prep_of [lemma='akt'] controlledt&e1: ents2Label-mention-ngram: the PI3Kt0e1: args2Role-mention-ngram: PI3K and CONTROLLEDtMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] themet0e1: args2Role-mention-ngram: expression involvest:e2: trigger-arg-path: Binding >prep_of [lemma='akt'] themet9e1: ents2Label-mention-ngram: expression involves bindingtGe1: trigger-arg-path: involves >nsubj >prep_of >nn Gene_or_gene_producttvshortest-path: dobj [lemma='binding']t-e1: ents2Label-mention-ngram: PI3K and SHAREDtYe1: trigger-arg-path: lemmatizedTrigger=involve >dobj >prep_of controlled:Phosphorylationtce1: trigger-arg-path: Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlledtJe2: trigger-arg-path: binding >prep_of [lemma='pi3k'] Gene_or_gene_productt]e1: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: and SHARED phosphorylatedtWe2: trigger-arg-path: binding:Binding >prep_of [lemma='akt'] theme:Gene_or_gene_producttRe1: trigger-arg-path: involves >nsubj >prep_of >nn controller:Gene_or_gene_productt:e2: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCT andtbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: involves binding oftHe1: trigger-arg-path: involves >dobj >prep_of controlled:PhosphorylationtXe2: trigger-arg-path: binding:Binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >prep_of [lemma='akt'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] Phosphorylationt%e1: args2Role-mention-ngram: PI3K andtQe1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_of >nn controllert]e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj >prep_of controlledthe1: trigger-arg-path: involves >dobj [lemma='binding'] >prep_of [lemma='akt'] controlled:Phosphorylationt)e2: args2Role-mention-ngram: of the THEMEt,e1: ents2Label-mention-ngram: binding of thet)e1: ents2Label-mention-ngram: of the PI3Kt(shortest-path: dobjt8e1: args2Role-mention-ngram: expression involves bindingtPe2: trigger-arg-path: Binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='akt'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: PI3K andtIe1: trigger-arg-path: lemmatizedTrigger=involve >dobj >prep_of controlledt?e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] Gene_or_gene_producttHe1: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn controllert?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controllertXe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_of >nn Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_of >nn controllertNe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_of >nn controllertLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='akt'] themet]e1: trigger-arg-path: involves >dobj [lemma='binding'] >prep_of [lemma='akt'] Phosphorylationt?e1: trigger-arg-path: involves >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT expression involvest9e2: ents2Label-mention-ngram: of the GENE_OR_GENE_PRODUCTtde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controller:Gene_or_gene_producttLe1: trigger-arg-path: involves:Positive_regulation >dobj >prep_of controlledt?e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controllertce1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_of >nn controller:Gene_or_gene_producttQe2: trigger-arg-path: binding:Binding >prep_of [lemma='akt'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: the PI3K andt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controllert?e1: trigger-arg-path: involves >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controller:Gene_or_gene_productt;e2: trigger-arg-path: Binding >prep_of [lemma='pi3k'] themet#e2: args2Role-mention-ngram: of thetXe1: trigger-arg-path: involves >dobj [lemma='binding'] >prep_of [lemma='akt'] controlledtRe1: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn Gene_or_gene_productt|e1: trigger-arg-path: involves:Positive_regulation >dobj [lemma='binding'] >prep_of [lemma='akt'] controlled:Phosphorylationtle1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_producttwe1: trigger-arg-path: involves >nsubj [lemma='activation'] >prep_of [lemma='expression'] >nn [lemma='ube2c'] controllertBe2: trigger-arg-path: binding:Binding >prep_of [lemma='akt'] themetme1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >dobj >prep_of controlled:Phosphorylationt.e1: ents2Label-mention-ngram: involves bindingt=e1: trigger-arg-path: involves >dobj >prep_of PhosphorylationtJe2: trigger-arg-path: Binding >prep_of [lemma='pi3k'] Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='akt'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: involves binding oftye1: trigger-arg-path: lemmatizedTrigger=involve >dobj [lemma='binding'] >prep_of [lemma='akt'] controlled:Phosphorylationtje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: of the PI3Ktie2: trigger-arg-path: lemmatizedTrigger=trigger nn [lemma='leukemia'] controllertce2: trigger-arg-path: triggered nn [lemma='leukemia'] Gene_or_gene_producttIe2: trigger-arg-path: triggered:Positive_regulation nn controllert&e1: ents2Label-mention-ngram: SHARED )tBe1: trigger-arg-path: triggered appos Gene_or_gene_productt-e1: args2Role-mention-ngram: ) expression andtme2: trigger-arg-path: triggered:Positive_regulation nn [lemma='leukemia'] controllertVe1: trigger-arg-path: triggered:Negative_regulation appos Gene_or_gene_producttTe1: trigger-arg-path: triggered:Negative_regulation >dobj controlled:Phosphorylationte2: trigger: triggeredtZe2: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] controlled:Phosphorylationt+e1: ents2Label-mention-ngram: and exogenoust*e1: args2Role-mention-ngram: LIF triggeredt+e2: args2Role-mention-ngram: expression andt>e2: ents2Label-mention-ngram: triggered SHARED phosphorylationt,e2: ents2Label-mention-ngram: expression andt_e1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] Phosphorylationt-e2: args2Role-mention-ngram: CONTROLLER ( LIFtse2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtJe2: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] controlledt*e1: args2Role-mention-ngram: exogenous LIFtfe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos Gene_or_gene_producttYe2: trigger-arg-path: triggered nn [lemma='leukemia'] controllert%e2: ents2Label-mention-ngram: ( LIF )tce2: trigger-arg-path: triggered:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt.e2: ents2Label-mention-ngram: LIF ) expressiontne1: trigger-arg-path: triggered:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt*e2: args2Role-mention-ngram: LIF triggeredtPe2: trigger-arg-path: lemmatizedTrigger=trigger >dobj controlled:PhosphorylationtZe1: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] controlled:Phosphorylationtse2: trigger-arg-path: lemmatizedTrigger=trigger nn [lemma='leukemia'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: exogenous LIF triggeredt&e1: args2Role-mention-ngram: triggeredt^e1: trigger-arg-path: triggered:Negative_regulation >dobj [lemma='phosphorylation'] controlledtde1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj controlled:Phosphorylationt8e1: trigger-arg-path: triggered appos controllertwe2: trigger-arg-path: triggered:Positive_regulation nn [lemma='leukemia'] Gene_or_gene_productt e1: args2Role-mention-ngram: LIFt)e2: args2Role-mention-ngram: ) expressiontxe2: trigger-arg-path: Positive_regulation nn [lemma='leukemia'] controller:Gene_or_gene_productt0e2: trigger-arg-path: triggered >dobj controlledtPe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj controlled:Phosphorylationt@e1: trigger-arg-path: lemmatizedTrigger=trigger >dobj controlledt@e1: trigger-arg-path: triggered >dobj controlled:Phosphorylationt*e2: args2Role-mention-ngram: exogenous LIFt&e2: args2Role-mention-ngram: exogenoustMe1: trigger-arg-path: triggered appos controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: exogenoust/e2: ents2Label-mention-ngram: and exogenous LIFt.e2: ents2Label-mention-ngram: triggered SHAREDt)e2: args2Role-mention-ngram: CONTROLLER (t'e1: ents2Label-mention-ngram: triggeredt e2: args2Role-mention-ngram: LIFt5e2: trigger-arg-path: triggered nn controllert?e1: trigger-arg-path: triggered:Negative_regulation appos [lemma='lif'] controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: exogenous LIF triggeredtZe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] controlledtDe2: trigger-arg-path: triggered:Positive_regulation >dobj controlledtSe2: trigger-arg-path: triggered:Positive_regulation nn Gene_or_gene_productt.e1: args2Role-mention-ngram: and exogenous LIFtTe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj controlledtJe1: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] controlledtue1: trigger-arg-path: triggered:Negative_regulation appos [lemma='lif'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=trigger appos Gene_or_gene_productt6e1: ents2Label-mention-ngram: expression and exogenoustLe1: trigger-arg-path: Negative_regulation appos Gene_or_gene_productt-e2: args2Role-mention-ngram: LIF ) expressiont+e2: ents2Label-mention-ngram: LIF triggeredtve1: trigger-arg-path: Negative_regulation appos [lemma='lif'] controller:Gene_or_gene_producttshortest-path: nntke1: trigger-arg-path: triggered:Negative_regulation appos [lemma='lif'] controllertEe2: trigger-arg-path: lemmatizedTrigger=trigger >dobj PhosphorylationtLe1: trigger-arg-path: triggered:Negative_regulation appos controllert"e2: args2Role-mention-ngram: ( LIFtne1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj [lemma='phosphorylation'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj Phosphorylationt1e1: args2Role-mention-ngram: triggered CONTROLLEDt6e2: ents2Label-mention-ngram: expression and exogenoustYe2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn controllertTe2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj controlledt}e2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn [lemma='leukemia'] controllert+e1: args2Role-mention-ngram: expression andtje2: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] controlled:Phosphorylationt+e2: ents2Label-mention-ngram: exogenous LIFtIe2: trigger-arg-path: triggered:Positive_regulation >dobj Phosphorylationtne2: trigger-arg-path: triggered nn [lemma='leukemia'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: ) expressiontae1: trigger-arg-path: triggered:Negative_regulation appos controller:Gene_or_gene_producttBe1: trigger-arg-path: Negative_regulation appos controllertqe1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: SHARED ) expressiont5e1: trigger-arg-path: triggered >dobj Phosphorylationt5e1: args2Role-mention-ngram: expression and exogenoust4e1: args2Role-mention-ngram: CONTROLLER ) expressiont*e1: args2Role-mention-ngram: and exogenoustce2: trigger-arg-path: Positive_regulation nn [lemma='leukemia'] controllert2e2: ents2Label-mention-ngram: LIF triggered SHAREDt?e2: trigger-arg-path: triggered:Positive_regulation nn [lemma='leukemia'] controller:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos controllert'e2: args2Role-mention-ngram: expressiont#e2: ents2Label-mention-ngram: ( LIFt'e1: ents2Label-mention-ngram: exogenoust5e1: args2Role-mention-ngram: LIF triggered CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos [lemma='lif'] controller:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=trigger nn [lemma='leukemia'] controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: and exogenoustge1: trigger-arg-path: lemmatizedTrigger=trigger appos [lemma='lif'] controllertae1: trigger-arg-path: Negative_regulation appos [lemma='lif'] controllertIe1: trigger-arg-path: triggered:Negative_regulation >dobj Phosphorylationt{e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos [lemma='lif'] controllert$e2: args2Role-mention-ngram: ( LIF )t.e2: ents2Label-mention-ngram: ) expression andtWe1: trigger-arg-path: Negative_regulation appos controller:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=trigger appos [lemma='lif'] controller:Gene_or_gene_producttce1: trigger-arg-path: triggered:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationtme2: trigger-arg-path: Positive_regulation nn [lemma='leukemia'] Gene_or_gene_producttne2: trigger-arg-path: triggered:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt(e2: ents2Label-mention-ngram: expressiont!e1: ents2Label-mention-ngram: LIFtje1: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] controlled:Phosphorylationtne2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn controller:Gene_or_gene_productt^e2: trigger-arg-path: triggered:Positive_regulation nn controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: LIF triggeredtke1: trigger-arg-path: Negative_regulation appos [lemma='lif'] Gene_or_gene_productt5e2: args2Role-mention-ngram: expression and exogenoustae1: trigger-arg-path: triggered appos [lemma='lif'] Gene_or_gene_productt1e2: args2Role-mention-ngram: triggered CONTROLLEDtWe1: trigger-arg-path: triggered appos [lemma='lif'] controllertqe1: trigger-arg-path: lemmatizedTrigger=trigger appos [lemma='lif'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=trigger nn Gene_or_gene_productt.e1: ents2Label-mention-ngram: triggered SHAREDt~e2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt-e2: args2Role-mention-ngram: ) expression andt_e2: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] Phosphorylationt+e1: ents2Label-mention-ngram: exogenous LIFt?e2: trigger-arg-path: triggered nn Gene_or_gene_productt+e2: ents2Label-mention-ngram: and exogenoust*e2: ents2Label-mention-ngram: SHARED ( LIFt5e2: args2Role-mention-ngram: LIF triggered CONTROLLEDt.e1: ents2Label-mention-ngram: ) expression andtTe2: trigger-arg-path: triggered:Positive_regulation >dobj controlled:Phosphorylationt2e1: ents2Label-mention-ngram: LIF triggered SHAREDt/e1: ents2Label-mention-ngram: and exogenous LIFtce2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj Phosphorylationtne2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj [lemma='phosphorylation'] controlledtDe1: trigger-arg-path: triggered:Negative_regulation >dobj controlledt~e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn [lemma='leukemia'] controller:Gene_or_gene_productt^e2: trigger-arg-path: triggered:Positive_regulation >dobj [lemma='phosphorylation'] controlledte1: trigger: triggeredt=shortest-path: nn [lemma='leukemia']t"e2: args2Role-mention-ngram: LIF )tEe1: trigger-arg-path: lemmatizedTrigger=trigger >dobj Phosphorylationt,e1: ents2Label-mention-ngram: expression andt?e2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nn [lemma='leukemia'] Gene_or_gene_productt5e2: trigger-arg-path: triggered >dobj Phosphorylationt>e1: ents2Label-mention-ngram: triggered SHARED phosphorylationtOe1: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] Phosphorylationt#e2: ents2Label-mention-ngram: LIF )tZe2: trigger-arg-path: lemmatizedTrigger=trigger nn controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: and exogenous LIFt*e1: ents2Label-mention-ngram: ) expressiontde2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >dobj controlled:Phosphorylationt@e2: trigger-arg-path: triggered >dobj controlled:PhosphorylationtOe2: trigger-arg-path: triggered >dobj [lemma='phosphorylation'] Phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=trigger appos controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=trigger >dobj controlledt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation appos [lemma='lif'] Gene_or_gene_productt4e2: args2Role-mention-ngram: exogenous LIF triggeredt!e2: ents2Label-mention-ngram: LIFtZe2: trigger-arg-path: lemmatizedTrigger=trigger >dobj [lemma='phosphorylation'] controlledt'e2: ents2Label-mention-ngram: triggeredtEe2: trigger-arg-path: lemmatizedTrigger=trigger nn controllert&e2: args2Role-mention-ngram: triggeredtHe1: trigger-arg-path: lemmatizedTrigger=trigger appos controllertJe2: trigger-arg-path: triggered nn controller:Gene_or_gene_productt0e1: trigger-arg-path: triggered >dobj controlledtle1: trigger-arg-path: triggered appos [lemma='lif'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=trigger:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt5e1: ents2Label-mention-ngram: exogenous LIF triggeredt*e2: ents2Label-mention-ngram: ) expressiontIe2: trigger-arg-path: complex:Binding nn [lemma='gdp'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gdp'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gdp'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gdp'] themet.e1: trigger-arg-path: complex nn [lemma='gdp'] themetCe2: trigger-arg-path: complex:Binding nn [lemma='gdp'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='gdp'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gdp'] Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='gdp'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gdp'] Gene_or_gene_productt:e1: trigger-arg-path: Binding nn [lemma='gdp'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gdp'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gdp'] themetTe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gdp'] theme:Gene_or_gene_producttJe1: trigger-arg-path: complex >nn [lemma='gdp'] theme:Gene_or_gene_producttLe1: trigger-arg-path: complex:Binding >nn [lemma='gdp'] Gene_or_gene_productt:e1: trigger-arg-path: complex nn [lemma='gdp'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gdp'] themet=e1: trigger-arg-path: complex:Binding >nn [lemma='gdp'] themet;e1: trigger-arg-path: complex nn [lemma='gdp'] themetOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gdp'] themetLe1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gdp'] Gene_or_gene_productt:e2: trigger-arg-path: complex nn [lemma='gdp'] themetBe2: trigger-arg-path: complex:Binding nn [lemma='gdp'] Gene_or_gene_productt;e1: trigger-arg-path: Binding nn [lemma='gdp'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gdp'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gdp'] themetFe2: trigger-arg-path: lemmatizedTrigger=complex prep_with [lemma='p53'] theme:Gene_or_gene_producttke1: trigger-arg-path: forms a complex nsubj [lemma='it'] themetle2: trigger-arg-path: lemmatizedTrigger=promote auxpass [lemma='be'] Bindingt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , andtie2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass controlled:Bindingt*e2: ents2Label-mention-ngram: DNA damage ,t^e2: trigger-arg-path: promotes auxpass [lemma='be'] controlledt&e2: ents2Label-mention-ngram: damage ,t:e2: ents2Label-mention-ngram: K120 by GENE_OR_GENE_PRODUCTt)e2: ents2Label-mention-ngram: response tot5e2: ents2Label-mention-ngram: upregulated in responsetOe2: trigger-arg-path: Positive_regulation auxpass controlled:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='p53'] theme:Gene_or_gene_producttauxpass controlledt-e1: ents2Label-mention-ngram: response to DNAt(e2: ents2Label-mention-ngram: DNA damaget&e2: args2Role-mention-ngram: of p53 att'e2: ents2Label-mention-ngram: of p53 attLe1: trigger-arg-path: forms a complex nsubj theme:Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='p53'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: and selectively promotestoe2: trigger-arg-path: lemmatizedTrigger=promote auxpass [lemma='be'] controlledt,e2: ents2Label-mention-ngram: in response tot1e2: args2Role-mention-ngram: selectively promotestWe2: trigger-arg-path: Positive_regulation >prep_by [lemma='tip60'] Gene_or_gene_producttwe1: trigger-arg-path: Binding prep_with [lemma='p53'] Gene_or_gene_productt1e1: args2Role-mention-ngram: THEME is upregulatedt+e1: args2Role-mention-ngram: is upregulatedt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass [lemma='be'] controlledt+e2: ents2Label-mention-ngram: to DNA damagetFe1: trigger-arg-path: forms a complex nsubj Generic_entitytbe2: trigger-arg-path: Positive_regulation >prep_by [lemma='tip60'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: selectively promotest?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='it'] themet4e1: args2Role-mention-ngram: upregulated in responset%e1: args2Role-mention-ngram: damage ,t%e1: args2Role-mention-ngram: responsette1: trigger-arg-path: forms a complex nsubj [lemma='it'] Generic_entitytTe1: trigger-arg-path: forms a complex:Binding nsubj theme:Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='p53'] theme:Gene_or_gene_producttfe2: trigger-arg-path: promotes auxpass [lemma='be'] controlled:Bindingt?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='p53'] Gene_or_gene_productt2e2: trigger-arg-path: promotes >prep_by controllertxe1: trigger-arg-path: forms a complex:Binding prep_with [lemma='p53'] themet9e2: trigger-arg-path: promotes auxpass Bindingt$e2: ents2Label-mention-ngram: p53 att?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='it'] Generic_entitytWe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by controllert/e2: args2Role-mention-ngram: the acetylation oftre1: trigger-arg-path: Binding nsubj [lemma='it'] theme:Generic_entityt+e1: args2Role-mention-ngram: damage , formstJe2: trigger-arg-path: lemmatizedTrigger=promote auxpass Bindingtoe2: trigger-arg-path: promotes:Positive_regulation auxpass [lemma='be'] Bindingt)e2: ents2Label-mention-ngram: p53 at K120t'e2: args2Role-mention-ngram: at K120 byt&e2: ents2Label-mention-ngram: responsetPe2: trigger-arg-path: promotes:Positive_regulation >prep_by Gene_or_gene_productt&e1: ents2Label-mention-ngram: damage ,t&e1: ents2Label-mention-ngram: responset)e1: ents2Label-mention-ngram: response totre2: trigger-arg-path: promotes:Positive_regulation auxpass [lemma='be'] controlledtGe2: trigger-arg-path: promotes >prep_by controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT ,t:e2: ents2Label-mention-ngram: p53 and GENE_OR_GENE_PRODUCTtCe2: trigger-arg-path: lemmatizedTrigger=promote >prep_by controllertFe2: trigger-arg-path: promotes:Positive_regulation >prep_by controllertfe2: trigger-arg-path: Positive_regulation auxpass [lemma='be'] Bindingt,e2: ents2Label-mention-ngram: upregulated int(e1: args2Role-mention-ngram: in responset%e2: ents2Label-mention-ngram: at K120tWe1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj Generic_entityt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass [lemma='be'] controlled:Bindingt-e2: ents2Label-mention-ngram: the acetylationtPe2: trigger-arg-path: promotes:Positive_regulation auxpass controlledtMe2: trigger-arg-path: Positive_regulation >prep_by [lemma='tip60'] controllert$e2: ents2Label-mention-ngram: of p53t>e1: trigger-arg-path: Binding nsubj Generic_entityt|e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='it'] Generic_entityt+e2: args2Role-mention-ngram: acetylation oft0e2: ents2Label-mention-ngram: the acetylation oft(e1: ents2Label-mention-ngram: DNA damaget5e2: args2Role-mention-ngram: and selectively promotest(e2: ents2Label-mention-ngram: at K120 byt6e2: ents2Label-mention-ngram: promotes the acetylationt%e2: ents2Label-mention-ngram: p53 andt/e2: args2Role-mention-ngram: K120 by CONTROLLERt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='it'] Generic_entitytpe1: trigger-arg-path: forms a complex prep_with [lemma='p53'] themetae2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by Gene_or_gene_productt*e2: ents2Label-mention-ngram: with p53 andthe2: trigger-arg-path: lemmatizedTrigger=promote >prep_by [lemma='tip60'] controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: , and selectivelyt[e2: trigger-arg-path: promotes:Positive_regulation >prep_by controller:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by [lemma='tip60'] Gene_or_gene_productt(e2: args2Role-mention-ngram: acetylationt+e1: args2Role-mention-ngram: in response tot6e2: ents2Label-mention-ngram: selectively promotes thet/e2: args2Role-mention-ngram: acetylation of p53t,e2: args2Role-mention-ngram: the acetylationt5e2: args2Role-mention-ngram: selectively promotes thetSe2: trigger-arg-path: lemmatizedTrigger=promote >prep_by [lemma='tip60'] controllert?e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='it'] theme:Generic_entityt!e2: ents2Label-mention-ngram: DNAt$e1: ents2Label-mention-ngram: to DNAt'e1: args2Role-mention-ngram: DNA damagetDe2: trigger-arg-path: promotes auxpass controlled:Bindingt+e1: ents2Label-mention-ngram: to DNA damaget#e2: args2Role-mention-ngram: p53 att(e2: args2Role-mention-ngram: p53 at K120t$e2: args2Role-mention-ngram: at K120t/e2: ents2Label-mention-ngram: is upregulated int)e2: ents2Label-mention-ngram: upregulatedtDshortest-path: auxpass [lemma='be']tXe2: trigger-arg-path: lemmatizedTrigger=promote >prep_by controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass controlledt(e1: args2Role-mention-ngram: response tot,e1: ents2Label-mention-ngram: is upregulatedt0e2: ents2Label-mention-ngram: acetylation of p53tee1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj theme:Generic_entityt'e2: ents2Label-mention-ngram: , forms at-e2: ents2Label-mention-ngram: and selectivelyt.e1: args2Role-mention-ngram: is upregulated int)e1: args2Role-mention-ngram: DNA damage ,tMe2: trigger-arg-path: lemmatizedTrigger=promote >prep_by Gene_or_gene_productt&e1: args2Role-mention-ngram: , forms atDe2: trigger-arg-path: Positive_regulation auxpass Bindingt/e2: ents2Label-mention-ngram: , and selectivelyt#e2: args2Role-mention-ngram: of p53tze2: trigger-arg-path: promotes:Positive_regulation auxpass [lemma='be'] controlled:Bindingt]e2: trigger-arg-path: lemmatizedTrigger=promote >prep_by [lemma='tip60'] Gene_or_gene_productt-e2: args2Role-mention-ngram: CONTROLLED , andt?trigger-to-trigger-path: e1:forms a complex:Binding >nsubj [lemma='it'] nsubj [lemma='it'] theme:Generic_entityt.e2: ents2Label-mention-ngram: complex with p53tMe2: trigger-arg-path: lemmatizedTrigger=promote auxpass controlledt3e1: ents2Label-mention-ngram: SHARED is upregulatedt,e2: args2Role-mention-ngram: and selectivelytze1: trigger-arg-path: forms a complex nsubj [lemma='it'] theme:Generic_entitytle2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by controller:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=promote auxpass [lemma='be'] controlled:Bindingt$e2: ents2Label-mention-ngram: to DNAt|e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='it'] themet%e2: ents2Label-mention-ngram: , formstMe2: trigger-arg-path: promotes:Positive_regulation auxpass Bindingt)e1: ents2Label-mention-ngram: upregulatedt-e2: ents2Label-mention-ngram: response to DNAt#e1: args2Role-mention-ngram: to DNAt$e1: ents2Label-mention-ngram: damaget?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='it'] theme:Generic_entityt,e1: args2Role-mention-ngram: response to DNAt^e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass Bindingt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='p53'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by [lemma='tip60'] controller:Gene_or_gene_producttse1: trigger-arg-path: forms a complex:Binding nsubj [lemma='it'] themet,e1: ents2Label-mention-ngram: in response totqe2: trigger-arg-path: Positive_regulation auxpass [lemma='be'] controlled:BindingtWe2: trigger-arg-path: promotes >prep_by [lemma='tip60'] controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: , andtVe2: trigger-arg-path: promotes:Positive_regulation >prep_by [lemma='tip60'] controllertatrigger-to-trigger-path: e1:forms a complex:Binding >nsubj auxpass controlled:Bindingt_e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj Generic_entitythe1: trigger-arg-path: Binding prep_with [lemma='p53'] themet$e1: args2Role-mention-ngram: , formst?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation auxpass [lemma='be'] BindingtDe1: trigger-arg-path: Binding nsubj theme:Generic_entityt'e1: ents2Label-mention-ngram: , forms at"e2: ents2Label-mention-ngram: K120t%e1: ents2Label-mention-ngram: , formstge2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_by [lemma='tip60'] controllerte1: trigger-arg-path: forms a complex prep_with [lemma='p53'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: upregulated in responset?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='p53'] themetNe1: trigger-arg-path: forms a complex:Binding nsubj Generic_entityt}e1: trigger-arg-path: Binding prep_with [lemma='p53'] theme:Gene_or_gene_productt?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='p53'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: damage , formstprep_by Gene_or_gene_producttle1: trigger-arg-path: Binding nsubj [lemma='it'] Generic_entitytke2: trigger-arg-path: promotes:Positive_regulation >prep_by [lemma='tip60'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: to DNA damaget`e2: trigger-arg-path: promotes:Positive_regulation >prep_by [lemma='tip60'] Gene_or_gene_productt(e1: args2Role-mention-ngram: upregulatedtUe2: trigger-arg-path: lemmatizedTrigger=promote auxpass controlled:BindingtBe2: trigger-arg-path: promotes >prep_by [lemma='tip60'] controllert$e2: ents2Label-mention-ngram: damaget?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='p53'] themet]e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj theme:Generic_entityt,e1: ents2Label-mention-ngram: upregulated intLe2: trigger-arg-path: promotes >prep_by [lemma='tip60'] Gene_or_gene_producttie2: trigger-arg-path: Positive_regulation auxpass [lemma='be'] controlledt/e1: ents2Label-mention-ngram: is upregulated int#e1: args2Role-mention-ngram: damaget[e2: trigger-arg-path: promotes auxpass [lemma='be'] BindingtGe2: trigger-arg-path: Positive_regulation auxpass controlledt*e1: ents2Label-mention-ngram: DNA damage ,tce1: trigger-arg-path: Binding nsubj [lemma='it'] themet'e1: ents2Label-mention-ngram: serum- ort/e1: ents2Label-mention-ngram: blocked serum- ortwe1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] Gene_or_gene_producttoshortest-path: ccomp [lemma='induce'] >nsubj [lemma='egf']t/e1: ents2Label-mention-ngram: or SHARED inducedtme1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controllert?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: siRNA blockedt!e2: ents2Label-mention-ngram: ERKt9e1: ents2Label-mention-ngram: of the GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: of the ERKt.e1: ents2Label-mention-ngram: by siRNA blockedt2e1: ents2Label-mention-ngram: siRNA blocked serum-t'e1: ents2Label-mention-ngram: or SHAREDt+e1: args2Role-mention-ngram: blocked serum-tke1: trigger-arg-path: blocked >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER by siRNAtve1: trigger-arg-path: blocked >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: blocked serum- ort:e2: ents2Label-mention-ngram: ERK and GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] Gene_or_gene_productt%e1: args2Role-mention-ngram: by siRNAt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT by siRNAtue1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controllert&e1: ents2Label-mention-ngram: by siRNAt"e1: args2Role-mention-ngram: siRNAt-e1: args2Role-mention-ngram: by siRNA blockedt#e1: ents2Label-mention-ngram: siRNAt*e1: args2Role-mention-ngram: siRNA blockedt)e2: ents2Label-mention-ngram: the ERK andt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: the ERKt$e1: ents2Label-mention-ngram: serum-t?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controllert,e1: ents2Label-mention-ngram: blocked serum-t{e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] Gene_or_gene_productt1e1: args2Role-mention-ngram: siRNA blocked serum-t?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: serum- or CONTROLLEDt%e2: ents2Label-mention-ngram: ERK andtae1: trigger-arg-path: blocked >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controllertqe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] controllert*e1: args2Role-mention-ngram: or CONTROLLEDt.e1: ents2Label-mention-ngram: serum- or SHAREDte1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='prohibitin'] Gene_or_gene_productt#e1: args2Role-mention-ngram: serum-t&e1: args2Role-mention-ngram: serum- ort]e2: trigger-arg-path: acetylation prep_by [lemma='tip60'] controllert%interceding-token ngrams: selectivelyt"interceding-token ngrams: promotest?trigger-to-trigger-path: e1:forms a complex:Binding >nsubj [lemma='it'] dobj [lemma='acetylation'] e2:acetylation:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] controllert?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] Gene_or_gene_producttoe2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] controller:Gene_or_gene_productt+interceding-token ngrams: , and selectivelytinterceding-token ngrams: Tip60t;e1: ents2Label-mention-ngram: GENERIC_ENTITY is upregulatedt%interceding-token ngrams: Tip60 , andt?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_productt.interceding-token ngrams: selectively promotest{e2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] Gene_or_gene_producttge2: trigger-arg-path: acetylation prep_by [lemma='tip60'] Gene_or_gene_productt2interceding-token ngrams: and selectively promotest)interceding-token ngrams: and selectivelyt/e1: ents2Label-mention-ngram: GENERIC_ENTITY istoe2: trigger-arg-path: lemmatizedTrigger=acetylation prep_by [lemma='tip60'] controllert!interceding-token ngrams: Tip60 ,t#interceding-token ngrams: and Tip60t?e2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_productt2interceding-token ngrams: selectively promotes thetqe2: trigger-arg-path: acetylation:Positive_regulation prep_by [lemma='tip60'] controllertze2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] controller:Gene_or_gene_producttFinterceding-tokens-full-span: and Tip60 , and selectively promotes thetre2: trigger-arg-path: acetylation prep_by [lemma='tip60'] controller:Gene_or_gene_producttee2: trigger-arg-path: Positive_regulation prep_by [lemma='tip60'] controllert,e2: ents2Label-mention-ngram: SHARED at K120t&interceding-token ngrams: promotes thet%interceding-token ngrams: and Tip60 ,tCshortest-path: dobj [lemma='acetylation']tjtrigger-to-trigger-path: e1:forms a complex:Binding >nsubj dobj e2:acetylation:Positive_regulationt/e1: ents2Label-mention-ngram: activity and p300tZe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='melatonin'] Simple_chemicaltQe2: trigger-arg-path: mediated >dobj [lemma='acetylation'] controlled:Acetylationt"e1: ents2Label-mention-ngram: p300tce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >nn Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='acetylation'] controlled:Acetylationt.e2: args2Role-mention-ngram: and p300 mediatedtOe2: trigger-arg-path: mediated:Positive_regulation >dobj controlled:AcetylationtXe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='melatonin'] controllert;e2: trigger-arg-path: mediated >dobj controlled:Acetylationtke2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='acetylation'] Acetylationt1e2: ents2Label-mention-ngram: SHARED activity andtTe1: trigger-arg-path: inhibits >nsubj [lemma='melatonin'] controller:Simple_chemicaltIe1: trigger-arg-path: inhibits:Negative_regulation >nsubj Simple_chemicalt%e2: args2Role-mention-ngram: and p300t.e2: args2Role-mention-ngram: activity and p300t-e1: ents2Label-mention-ngram: SHARED activitytve2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='acetylation'] controlled:Acetylationte2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >nn Gene_or_gene_producttHe2: trigger-arg-path: mediated:Positive_regulation >nsubj >nn controllert"e2: ents2Label-mention-ngram: p300t&e1: ents2Label-mention-ngram: activitytTe1: trigger-arg-path: inhibits:Negative_regulation >nsubj controller:Simple_chemicaltqe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='activity'] >nn [lemma='p300'] Gene_or_gene_producttte2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] Gene_or_gene_productt5e2: args2Role-mention-ngram: p300 mediated CONTROLLEDtVe2: trigger-arg-path: mediated >nsubj [lemma='activity'] >nn [lemma='p300'] controllertFe2: trigger-arg-path: mediated >dobj [lemma='acetylation'] Acetylationt]e2: trigger-arg-path: mediated:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttDe2: trigger-arg-path: mediated:Positive_regulation >dobj AcetylationtRe2: trigger-arg-path: mediated:Positive_regulation >nsubj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controller:Gene_or_gene_producttCe2: trigger-arg-path: mediated:Positive_regulation >dobj controlledt9e1: ents2Label-mention-ngram: mediated SHARED acetylationtke2: trigger-arg-path: mediated >nsubj [lemma='activity'] >nn [lemma='p300'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: and p300 mediatedt&e1: ents2Label-mention-ngram: and p300t>e2: trigger-arg-path: mediated >nsubj >nn Gene_or_gene_productt*e1: ents2Label-mention-ngram: activity andtie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='melatonin'] controllert&e2: ents2Label-mention-ngram: and p300t|e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='activity'] >nn [lemma='p300'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: CONTROLLER activity andt2e1: ents2Label-mention-ngram: p300 mediated SHAREDt/e2: ents2Label-mention-ngram: activity and p300tke2: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj controller:Simple_chemicaltYe2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='acetylation'] controlledtee2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='acetylation'] controlled:Acetylationt*e2: ents2Label-mention-ngram: activity andtge2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='activity'] >nn [lemma='p300'] controllert*e2: args2Role-mention-ngram: p300 mediatedtje2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controllert`e2: trigger-arg-path: mediated >nsubj [lemma='activity'] >nn [lemma='p300'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >nn controllerthe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='melatonin'] controller:Simple_chemicalt0e2: args2Role-mention-ngram: CONTROLLER activityt]e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='melatonin'] Simple_chemicaltIe1: trigger-arg-path: inhibits >nsubj [lemma='melatonin'] Simple_chemicaltne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttve2: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Negative_regulation >nsubj [lemma='melatonin'] controller:Simple_chemicaltUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj Acetylationtye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='melatonin'] controller:Simple_chemicaltee1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='melatonin'] controller:Simple_chemicalt9e2: ents2Label-mention-ngram: mediated SHARED acetylationtAe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj Acetylationtmshortest-path: ccomp [lemma='mediate'] >nsubj [lemma='activity'] >nn [lemma='p300']tTe1: trigger-arg-path: Negative_regulation >nsubj [lemma='melatonin'] Simple_chemicaltWe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='acetylation'] Acetylationt0e2: trigger-arg-path: mediated >dobj AcetylationtEe2: trigger-arg-path: mediated >dobj [lemma='acetylation'] controlledt+e2: ents2Label-mention-ngram: p300 mediatedt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] Gene_or_gene_producttDe1: trigger-arg-path: inhibits >nsubj [lemma='melatonin'] controllert)e2: args2Role-mention-ngram: activity andt{e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controllertFe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Simple_chemicaltUe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='melatonin'] controllert4e2: trigger-arg-path: mediated >nsubj >nn controllert5e1: trigger-arg-path: inhibits >nsubj Simple_chemicalt_trigger-to-trigger-path: e1:inhibits:Negative_regulation >ccomp e2:mediated:Positive_regulationtZe2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='acetylation'] Acetylationt`e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlled:AcetylationtZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >nn controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: p300t2e2: ents2Label-mention-ngram: p300 mediated SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >nn controllertae2: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='p300'] controllert=e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL inhibits SHAREDtje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='acetylation'] controlledtne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='melatonin'] Simple_chemicalt-e2: ents2Label-mention-ngram: SHARED activityt6e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL inhibitstVe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='acetylation'] controlledtQe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:Simple_chemicalt@e1: trigger-arg-path: inhibits >nsubj controller:Simple_chemicalt+e1: ents2Label-mention-ngram: p300 mediatedtZe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj Simple_chemicalt1e1: ents2Label-mention-ngram: SHARED activity andt/e2: trigger-arg-path: mediated >dobj controlledtLe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlled:AcetylationtIe2: trigger-arg-path: mediated >nsubj >nn controller:Gene_or_gene_producttqtrigger-to-trigger-path: e1:inhibits:Negative_regulation >ccomp [lemma='mediate'] e2:mediated:Positive_regulationt6e1: ents2Label-mention-ngram: inhibits SHARED activitytOe1: trigger-arg-path: Negative_regulation >nsubj [lemma='melatonin'] controllert/e1: ents2Label-mention-ngram: and p300 mediatedt(interceding-token ngrams: Wortmannin andtIe2: trigger-arg-path: mediated >nsubj [lemma='afgf'] Gene_or_gene_productt{e2: trigger-arg-path: mediated >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: mediated >ccomp >nsubj >nn controlled:Gene_or_gene_productt?e2: trigger-arg-path: mediated >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlled:Gene_or_gene_productt(interceding-token ngrams: a specific MEKt7e1: ents2Label-mention-ngram: phosphorylation at Ser386tSe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='afgf'] controllert?e1: trigger-arg-path: mediated >nsubj [lemma='afgf'] controllert+e1: ents2Label-mention-ngram: the treatmentt$interceding-token ngrams: inhibitorst)interceding-token ngrams: indicating thattee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='afgf'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: phosphorylation att]e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='afgf'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='afgf'] Gene_or_gene_productt?trigger-to-trigger-path: e1:mediated:Positive_regulation >conj_but [lemma='indicate'] >ccomp [lemma='mediate'] e2:mediated:Positive_activationtde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='afgf'] controllert,interceding-token ngrams: not Wortmannin andt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlledtTe2: trigger-arg-path: mediated >nsubj [lemma='afgf'] controller:Gene_or_gene_productt%interceding-token ngrams: inhibitor ,t1interceding-token ngrams: Wortmannin and LY294002t$interceding-token ngrams: WortmannintLe2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj >nn controlledtZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] Gene_or_gene_productt#interceding-token ngrams: , but nott)interceding-token ngrams: MEK inhibitor ,t7e1: ents2Label-mention-ngram: SHARED phosphorylation atthe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='afgf'] controller:Gene_or_gene_producttEe2: trigger-arg-path: mediated >ccomp >nsubj >nn Gene_or_gene_productt]e2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='afgf'] Gene_or_gene_producttYe2: trigger-arg-path: mediated:Positive_activation >nsubj controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: the treatment oft.e1: ents2Label-mention-ngram: by the treatmenttitrigger-to-trigger-path: e1:mediated:Positive_regulation >conj_but >ccomp e2:mediated:Positive_activationtinterceding-tokens-full-span: , a specific MEK inhibitor , but not Wortmannin and LY294002 , PI3-K inhibitors , indicating thattde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='afgf'] controllert&interceding-token ngrams: , indicatingtqe2: trigger-arg-path: mediated >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlledt'interceding-token ngrams: MEK inhibitortFe2: trigger-arg-path: Positive_activation >ccomp >nsubj >nn controlledt-shortest-path: conj_but >ccomp >nsubjtYe2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubj >nn Gene_or_gene_productt1e1: ents2Label-mention-ngram: Ser386 is inhibitedtOe2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubj >nn controlledtTe1: trigger-arg-path: mediated >nsubj [lemma='afgf'] controller:Gene_or_gene_producttIe1: trigger-arg-path: mediated >nsubj [lemma='afgf'] Gene_or_gene_productt;e2: trigger-arg-path: mediated >ccomp >nsubj >nn controlledt,interceding-token ngrams: but not Wortmannint*e1: ents2Label-mention-ngram: at Ser386 istue2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubj >nn controlled:Gene_or_gene_productt[e2: trigger-arg-path: Positive_activation >ccomp >nsubj >nn controlled:Gene_or_gene_productt*e1: ents2Label-mention-ngram: inhibited bytVe2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj >nn Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='afgf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='afgf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlled:Gene_or_gene_productt(interceding-token ngrams: and LY294002 ,t&interceding-token ngrams: specific MEKt?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: mediated >nsubj [lemma='afgf'] controllert:e1: ents2Label-mention-ngram: treatment of SIMPLE_CHEMICALtTe2: trigger-arg-path: Positive_activation >nsubj [lemma='afgf'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] Gene_or_gene_productthe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='afgf'] controller:Gene_or_gene_productt1interceding-token ngrams: inhibitors , indicatingt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] Gene_or_gene_productt"interceding-token ngrams: LY294002t#interceding-token ngrams: inhibitort$interceding-token ngrams: indicatingt-e1: ents2Label-mention-ngram: is inhibited bytinterceding-token ngrams: PI3-Kt$e1: ents2Label-mention-ngram: Ser386tTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='afgf'] Gene_or_gene_productt$interceding-token ngrams: LY294002 ,t?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlledtNe2: trigger-arg-path: mediated:Positive_activation >nsubj Gene_or_gene_productt0e1: ents2Label-mention-ngram: of SIMPLE_CHEMICALtDe2: trigger-arg-path: mediated:Positive_activation >nsubj controllert&interceding-token ngrams: , a specifict&interceding-token ngrams: inhibitors ,t&interceding-token ngrams: and LY294002tSe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='afgf'] controllertne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='afgf'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] controller:Gene_or_gene_productt|e2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] controlledt,interceding-token ngrams: PI3-K inhibitors ,tje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: inhibited by thet'e1: ents2Label-mention-ngram: at Ser386tJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='afgf'] controllertde2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubj >nn controlled:Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >nsubj [lemma='afgf'] controllertae2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubj >nn controlled:Gene_or_gene_productt'e1: ents2Label-mention-ngram: Ser386 istPe2: trigger-arg-path: Positive_activation >ccomp >nsubj >nn Gene_or_gene_productt$interceding-token ngrams: a specifict`e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubj >nn controlledtZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] Gene_or_gene_productt(interceding-token ngrams: not Wortmannint0interceding-token ngrams: specific MEK inhibitort)interceding-token ngrams: inhibitor , butt,interceding-token ngrams: , PI3-K inhibitorst+interceding-token ngrams: , indicating thattUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj controllert?e2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='activation'] >nn [lemma='rsk2'] Gene_or_gene_producttsshortest-path: conj_but [lemma='indicate'] >ccomp [lemma='mediate'] >nsubj [lemma='afgf']t!interceding-token ngrams: , PI3-KtPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] controllert*interceding-token ngrams: PI3-K inhibitorstje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubj >nn Gene_or_gene_productt*e1: ents2Label-mention-ngram: is inhibitedtPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='afgf'] controllert_e2: trigger-arg-path: Positive_activation >nsubj [lemma='afgf'] controller:Gene_or_gene_productt*interceding-token ngrams: LY294002 , PI3-KtDshortest-path: dobj [lemma='sequestration']tBe1: trigger-arg-path: Phosphorylation >prep_of >prep_by controllertfe2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='p-pras40'] Gene_or_gene_producttHe2: trigger-arg-path: Positive_activation prep_by >num controllert7e1: ents2Label-mention-ngram: Phosphorylation of SHAREDtVe1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by controllertTe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by controllertse2: trigger-arg-path: sequestration:Positive_activation >prep_of [lemma='p-pras40'] controlled:Gene_or_gene_producttBe2: trigger-arg-path: sequestration prep_by >num controllertre2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controller:Gene_or_gene_producttve1: trigger-arg-path: Phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controller:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by controllertprep_of Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of Gene_or_gene_productt8e2: args2Role-mention-ngram: sequestration of CONTROLLEDt^e2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by >num Gene_or_gene_producttze1: trigger-arg-path: Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controller:Gene_or_gene_producttAe2: trigger-arg-path: sequestration >prep_of Gene_or_gene_producttve2: trigger-arg-path: sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] controllertqe2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='p-pras40'] controlled:Gene_or_gene_productt.e2: ents2Label-mention-ngram: sequestration oft]e2: trigger-arg-path: Positive_activation prep_by >num controller:Gene_or_gene_productt?e2: trigger-arg-path: sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controllert?e1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] Gene_or_gene_producttRe2: trigger-arg-path: Positive_activation prep_by >num Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by >num controllertpe2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of [lemma='p-pras40'] controlledthe2: trigger-arg-path: sequestration:Positive_activation >prep_of [lemma='p-pras40'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of controlledt\e2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='p-pras40'] controlledt^e2: trigger-arg-path: sequestration:Positive_activation >prep_of [lemma='p-pras40'] controlledt_e2: trigger-arg-path: sequestration >prep_of [lemma='p-pras40'] controlled:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by >num Gene_or_gene_producttke1: trigger-arg-path: Phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] Gene_or_gene_productt*e2: args2Role-mention-ngram: sequestrationtie2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by >num controller:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of controlledt-e2: args2Role-mention-ngram: sequestration ofte1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] Gene_or_gene_productt|e2: trigger-arg-path: Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controllert?e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of [lemma='p-pras40'] controlled:Gene_or_gene_producttue1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controllertke2: trigger-arg-path: sequestration:Positive_activation prep_by >num controller:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by >num controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] controllertze2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of [lemma='p-pras40'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt+e2: ents2Label-mention-ngram: sequestrationtLe2: trigger-arg-path: sequestration >prep_of controlled:Gene_or_gene_productt7e2: trigger-arg-path: sequestration >prep_of controlledt?e2: trigger-arg-path: sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] controller:Gene_or_gene_productt`e2: trigger-arg-path: sequestration:Positive_activation >prep_of controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: Phosphorylation oft?e2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] Gene_or_gene_producttae1: trigger-arg-path: Phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controllertJe2: trigger-arg-path: sequestration >prep_of [lemma='p-pras40'] controlledtqtrigger-to-trigger-path: e1:Phosphorylation:Positive_regulation dobj e2:sequestration:Positive_activationt`e1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation >prep_of Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation >prep_of [lemma='p-pras40'] controlledtoe1: trigger-arg-path: Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] Gene_or_gene_productt?e2: trigger-arg-path: sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controller:Gene_or_gene_productt?e2: trigger-arg-path: sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] Gene_or_gene_producttWe1: trigger-arg-path: Phosphorylation >prep_of >prep_by controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: Phosphorylationt?e2: trigger-arg-path: sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] Gene_or_gene_productt%interceding-tokens-full-span: inducest?e2: trigger-arg-path: lemmatizedTrigger=sequestration:Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controllert[e1: trigger-arg-path: Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttee2: trigger-arg-path: Positive_activation >prep_of [lemma='p-pras40'] controlled:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by controller:Gene_or_gene_producttVe2: trigger-arg-path: sequestration:Positive_activation prep_by >num controllertZe2: trigger-arg-path: Positive_activation >prep_of [lemma='p-pras40'] Gene_or_gene_productte1: trigger: Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by [lemma='protein'] >num [lemma='14-3-3'] Gene_or_gene_producttKe2: trigger-arg-path: sequestration:Positive_activation >prep_of controlledtTe2: trigger-arg-path: lemmatizedTrigger=sequestration prep_by >num controllertPe1: trigger-arg-path: Positive_regulation >prep_of >prep_by Gene_or_gene_productt?trigger-to-trigger-path: e1:Phosphorylation:Positive_regulation dobj [lemma='sequestration'] e2:sequestration:Positive_activationt}e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controllertTe2: trigger-arg-path: sequestration >prep_of [lemma='p-pras40'] Gene_or_gene_productt`e2: trigger-arg-path: sequestration:Positive_activation prep_by >num Gene_or_gene_producttke1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttee1: trigger-arg-path: Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controller:Gene_or_gene_productte2: trigger: sequestrationt5e2: ents2Label-mention-ngram: sequestration of SHAREDt^e2: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of controlled:Gene_or_gene_producttLe1: trigger-arg-path: Phosphorylation >prep_of >prep_by Gene_or_gene_producttFe1: trigger-arg-path: Positive_regulation >prep_of >prep_by controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pras40'] >prep_by [lemma='akt'] controllertLe2: trigger-arg-path: sequestration prep_by >num Gene_or_gene_producttWe2: trigger-arg-path: sequestration prep_by >num controller:Gene_or_gene_productt!interceding-token ngrams: inducest?e2: trigger-arg-path: Positive_activation prep_by [lemma='protein'] >num [lemma='14-3-3'] controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controlledtTe2: trigger-arg-path: lemmatizedTrigger=promote >prep_with [lemma='vdac'] controllert>shortest-path: advmod [lemma='also']t+e2: ents2Label-mention-ngram: promoting itstce2: trigger-arg-path: promoting:Positive_regulation nsubj controlled:Positive_regulationtNe2: trigger-arg-path: promoting >prep_with [lemma='vdac'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED IIt>e1: trigger-arg-path: promotes >nsubj [lemma='AKT'] controllert(e2: ents2Label-mention-ngram: HKII ) andt?e2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='AKT'] controlled:Positive_regulationt'e2: args2Role-mention-ngram: HKII ) andtoe2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='AKT'] controlledt;e2: ents2Label-mention-ngram: glycolysis by phosphorylatingt^e2: trigger-arg-path: promoting:Positive_regulation >prep_with controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: ) and promotingtSe1: trigger-arg-path: promotes >nsubj [lemma='AKT'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: its interactiont5e2: ents2Label-mention-ngram: interaction with SHAREDtee2: trigger-arg-path: Positive_regulation nsubj [lemma='AKT'] controlledtKe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controlledt4e1: ents2Label-mention-ngram: phosphorylating SHAREDtDe2: trigger-arg-path: promoting >prep_with [lemma='vdac'] controllertRe1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='AKT'] controllert7e2: ents2Label-mention-ngram: phosphorylating SHARED IItSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='AKT'] Gene_or_gene_producttce2: trigger-arg-path: Positive_regulation >prep_with [lemma='vdac'] controller:Gene_or_gene_producttYe1: trigger-arg-path: promotes:Positive_regulation >nsubj controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: its interaction withthe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj Positive_regulationt+e1: ents2Label-mention-ngram: glycolysis byt^e2: trigger-arg-path: lemmatizedTrigger=promote >prep_with [lemma='vdac'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='AKT'] controllertoe2: trigger-arg-path: promoting nsubj [lemma='AKT'] controlled:Positive_regulationt+e1: ents2Label-mention-ngram: also promotest$e2: ents2Label-mention-ngram: ( HKIItce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='AKT'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: promotes glycolysis bytxe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='AKT'] controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='AKT'] controllert*e2: args2Role-mention-ngram: and promotingtHe1: trigger-arg-path: promotes >nsubj [lemma='AKT'] Gene_or_gene_producttDe1: trigger-arg-path: promotes:Positive_regulation >nsubj controllert;e1: ents2Label-mention-ngram: glycolysis by phosphorylatingt!e2: ents2Label-mention-ngram: itst;e2: trigger-arg-path: promoting nsubj controlledt-e1: ents2Label-mention-ngram: ) and promotingt(e1: ents2Label-mention-ngram: HKII ) andtXe2: trigger-arg-path: promoting:Positive_regulation >prep_with [lemma='vdac'] controllertre2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with [lemma='vdac'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >prep_with controllert7e1: ents2Label-mention-ngram: phosphorylating SHARED IIt+e1: ents2Label-mention-ngram: promoting itstNe2: trigger-arg-path: Positive_regulation nsubj Positive_regulationtctrigger-to-trigger-path: e1:promotes:Positive_regulation >prepc_by e2:promoting:Positive_regulationtNe1: trigger-arg-path: promotes:Positive_regulation >nsubj Gene_or_gene_productt-e1: ents2Label-mention-ngram: its interactiontVe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: glycolysis bytbe2: trigger-arg-path: promoting:Positive_regulation >prep_with [lemma='vdac'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: phosphorylatingt/e1: ents2Label-mention-ngram: and promoting itstEe2: trigger-arg-path: lemmatizedTrigger=promote >prep_with controllert*e2: args2Role-mention-ngram: CONTROLLED IIt,e2: args2Role-mention-ngram: its interactiont e2: ents2Label-mention-ngram: IIt$e2: ents2Label-mention-ngram: HKII )t6e2: args2Role-mention-ngram: promoting its interactiontxe2: trigger-arg-path: promoting:Positive_regulation nsubj [lemma='AKT'] Positive_regulationt,e2: args2Role-mention-ngram: CONTROLLED II (t+e2: ents2Label-mention-ngram: and promotingt2e1: ents2Label-mention-ngram: SHARED also promotest2e1: ents2Label-mention-ngram: its interaction witht0e1: ents2Label-mention-ngram: by phosphorylatingtTe2: trigger-arg-path: Positive_regulation >prep_with controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=promote >prep_with Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='AKT'] controllert#e2: args2Role-mention-ngram: ( HKIIt3e1: args2Role-mention-ngram: promotes glycolysis bytYe2: trigger-arg-path: promoting >prep_with [lemma='vdac'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: with CONTROLLERte2: args2Role-mention-ngram: IIte2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='AKT'] controlledt\e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='AKT'] Gene_or_gene_producttge1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='AKT'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: HKIIt5e1: args2Role-mention-ngram: CONTROLLER also promotestTe2: trigger-arg-path: lemmatizedTrigger=promote nsubj Positive_regulationtye2: trigger-arg-path: Positive_regulation nsubj [lemma='AKT'] controlled:Positive_regulationt7e2: ents2Label-mention-ngram: promoting its interactiontse2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controlled:Positive_regulationt%e2: args2Role-mention-ngram: ( HKII )tAe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj controllertJe2: trigger-arg-path: promoting >prep_with controller:Gene_or_gene_producttSe2: trigger-arg-path: promoting:Positive_regulation >prep_with Gene_or_gene_productt1e1: ents2Label-mention-ngram: promotes glycolysist4e1: ents2Label-mention-ngram: promotes glycolysis byt4e2: ents2Label-mention-ngram: phosphorylating SHAREDt7e2: ents2Label-mention-ngram: by phosphorylating SHAREDtYe2: trigger-arg-path: Positive_regulation nsubj controlled:Positive_regulationtIe2: trigger-arg-path: Positive_regulation >prep_with Gene_or_gene_productt6e1: ents2Label-mention-ngram: also promotes glycolysistEe2: trigger-arg-path: Positive_regulation nsubj controlledt5e2: trigger-arg-path: promoting >prep_with controllert}e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with [lemma='vdac'] controller:Gene_or_gene_productt5e1: args2Role-mention-ngram: glycolysis by CONTROLLEDtje1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controller:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='AKT'] controlled:Positive_regulationtde1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='AKT'] controller:Gene_or_gene_producttDe2: trigger-arg-path: promoting nsubj Positive_regulationtne2: trigger-arg-path: Positive_regulation nsubj [lemma='AKT'] Positive_regulationt#e2: args2Role-mention-ngram: HKII )t e2: args2Role-mention-ngram: itst*e1: args2Role-mention-ngram: also promotestEe1: trigger-arg-path: promotes >nsubj controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with [lemma='vdac'] controllert)e2: ents2Label-mention-ngram: SHARED alsot%e1: args2Role-mention-ngram: promotestutrigger-to-trigger-path: e1:promotes:Positive_regulation >prepc_by [lemma='promote'] e2:promoting:Positive_regulationt7e1: ents2Label-mention-ngram: promoting its interactiont.e2: args2Role-mention-ngram: and promoting itstXe2: trigger-arg-path: Positive_regulation >prep_with [lemma='vdac'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=promote >prep_with [lemma='vdac'] controller:Gene_or_gene_producttIe2: trigger-arg-path: promoting:Positive_regulation >prep_with controllertke2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='AKT'] controlledt0e2: ents2Label-mention-ngram: by phosphorylatingt-e1: ents2Label-mention-ngram: phosphorylatingt'e2: ents2Label-mention-ngram: SHARED IIt&e1: ents2Label-mention-ngram: promotest?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='AKT'] controlled:Positive_regulationtYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with controllert)e2: ents2Label-mention-ngram: SHARED II (t!e2: args2Role-mention-ngram: II (tUe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controllert[e2: trigger-arg-path: promoting nsubj [lemma='AKT'] controlledt"e2: ents2Label-mention-ngram: HKIIt7e1: ents2Label-mention-ngram: by phosphorylating SHAREDt:e1: trigger-arg-path: promotes >nsubj Gene_or_gene_productt5e1: ents2Label-mention-ngram: interaction with SHAREDt8e2: args2Role-mention-ngram: interaction with CONTROLLERt&e2: ents2Label-mention-ngram: ( HKII )t'e2: ents2Label-mention-ngram: II ( HKIIt&e2: args2Role-mention-ngram: II ( HKIItYe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='AKT'] Gene_or_gene_producttXe2: trigger-arg-path: promoting:Positive_regulation nsubj Positive_regulationt5e1: args2Role-mention-ngram: also promotes glycolysist+e1: ents2Label-mention-ngram: and promotingtme1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='AKT'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with controller:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >prep_with [lemma='vdac'] controllert*e2: args2Role-mention-ngram: promoting itst(e2: ents2Label-mention-ngram: glycolysist1e2: ents2Label-mention-ngram: promotes glycolysist+e2: ents2Label-mention-ngram: glycolysis byt_e2: trigger-arg-path: lemmatizedTrigger=promote nsubj controlled:Positive_regulationt/e2: ents2Label-mention-ngram: and promoting itst1e2: args2Role-mention-ngram: its interaction witht0e1: args2Role-mention-ngram: promotes glycolysist+e2: ents2Label-mention-ngram: also promotestZe2: trigger-arg-path: lemmatizedTrigger=promote >prep_with controller:Gene_or_gene_producttme2: trigger-arg-path: promoting:Positive_regulation >prep_with [lemma='vdac'] controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: also promotes glycolysistOe2: trigger-arg-path: promoting nsubj controlled:Positive_regulationt0e1: trigger-arg-path: promotes >nsubj controllertOe2: trigger-arg-path: promoting:Positive_regulation nsubj controlledt2e2: ents2Label-mention-ngram: SHARED also promotest)e1: ents2Label-mention-ngram: SHARED II (t-e2: ents2Label-mention-ngram: ) and promotingtte2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='AKT'] Positive_regulationt*e1: args2Role-mention-ngram: by CONTROLLEDt?e2: trigger-arg-path: promoting >prep_with Gene_or_gene_productte1: trigger: promotest?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='AKT'] Positive_regulationtde2: trigger-arg-path: promoting nsubj [lemma='AKT'] Positive_regulationt"e2: ents2Label-mention-ngram: II (tNe1: trigger-arg-path: lemmatizedTrigger=binding >nn theme:Gene_or_gene_producttAe2: trigger-arg-path: binding prep_to Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='c-raf'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] themetSe2: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_producttTe1: trigger-arg-path: Binding prep_to [lemma='b-raf'] themetue2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_productt'e1: trigger-arg-path: binding >nn themet2e1: trigger-arg-path: binding prep_to themet$shortest-path: prep_to [lemma='b-raf'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] themet7e2: trigger-arg-path: Binding >nn [lemma='c-raf'] themet{e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttie1: trigger-arg-path: Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_productt2e1: trigger-arg-path: Binding prep_to themetGe1: trigger-arg-path: binding prep_to theme:Gene_or_gene_producttAe2: trigger-arg-path: Binding prep_to Gene_or_gene_producttDe1: trigger-arg-path: binding:Binding >nn theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=binding >nn theme:Gene_or_gene_producttTe2: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binding:Binding >nn Gene_or_gene_productt9e1: trigger-arg-path: lemmatizedTrigger=binding >nn themet[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_producttke1: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] Gene_or_gene_producttnn theme:Gene_or_gene_producttLe1: trigger-arg-path: Binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_productt7e1: trigger-arg-path: Binding >nn [lemma='c-raf'] themetie2: trigger-arg-path: binding prep_to [lemma='b-raf'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=binding >nn Gene_or_gene_producttIe2: trigger-arg-path: binding:Binding prep_to Gene_or_gene_producttGe2: trigger-arg-path: binding prep_to theme:Gene_or_gene_producttTe1: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttie2: trigger-arg-path: Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] themet}e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] Gene_or_gene_producttFe1: trigger-arg-path: binding >nn [lemma='c-raf'] Gene_or_gene_producttDe2: trigger-arg-path: binding:Binding >nn theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] themetGe1: trigger-arg-path: Binding prep_to theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] Gene_or_gene_productt>e2: trigger-arg-path: binding:Binding >nn Gene_or_gene_productt:e1: trigger-arg-path: binding:Binding prep_to themetFe1: trigger-arg-path: Binding >nn [lemma='c-raf'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_producttce1: trigger-arg-path: Binding prep_to [lemma='b-raf'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] themetDe1: trigger-arg-path: lemmatizedTrigger=binding prep_to themet^e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn themetLe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themetqe2: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_productt7e2: trigger-arg-path: binding >nn [lemma='c-raf'] themetfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=binding >nn Gene_or_gene_producttke2: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] Gene_or_gene_producttce2: trigger-arg-path: Binding prep_to [lemma='b-raf'] Gene_or_gene_productt\e1: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] themet\e2: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] themet6e1: trigger-arg-path: binding >nn Gene_or_gene_productt2e2: trigger-arg-path: Binding prep_to themetPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn Gene_or_gene_producttLe1: trigger-arg-path: binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themetQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] themetGe2: trigger-arg-path: Binding prep_to theme:Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] themetPe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_producttqe1: trigger-arg-path: binding:Binding prep_to [lemma='b-raf'] theme:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=binding prep_to themet/e1: trigger-arg-path: binding:Binding >nn themetOe1: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] themet7e1: trigger-arg-path: binding >nn [lemma='c-raf'] themet2e2: trigger-arg-path: binding prep_to themetce1: trigger-arg-path: binding prep_to [lemma='b-raf'] Gene_or_gene_producttNe2: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_producttAe1: trigger-arg-path: Binding prep_to Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_producttAe1: trigger-arg-path: binding prep_to Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] Gene_or_gene_producttTe2: trigger-arg-path: Binding prep_to [lemma='b-raf'] themetce2: trigger-arg-path: binding prep_to [lemma='b-raf'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-raf'] theme:Gene_or_gene_producttOe2: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_producttnn theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] themet6e2: trigger-arg-path: binding >nn Gene_or_gene_productt:e2: trigger-arg-path: binding:Binding prep_to themet}e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='b-raf'] Gene_or_gene_producttIe1: trigger-arg-path: binding:Binding prep_to Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-raf'] Gene_or_gene_producttFe2: trigger-arg-path: binding >nn [lemma='c-raf'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='b-raf'] theme:Gene_or_gene_producttTe2: trigger-arg-path: binding prep_to [lemma='b-raf'] themetTe1: trigger-arg-path: binding prep_to [lemma='b-raf'] themet?e2: trigger-arg-path: binding:Binding >nn [lemma='c-raf'] themetLe1: trigger-arg-path: binds >nsubj [lemma='calmodulin'] Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >prep_to [lemma='hra'] Gene_or_gene_productt&interceding-token ngrams: and KRas andtTe1: trigger-arg-path: binds:Binding >nsubj [lemma='calmodulin'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='they'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='calmodulin'] Gene_or_gene_productt@e2: trigger-arg-path: binding:Binding >poss theme:Generic_entityt2e2: trigger-arg-path: binding >poss Generic_entitytXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hra'] Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=binding >poss Generic_entitytQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hra'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hra'] themet8e2: trigger-arg-path: binding >poss theme:Generic_entitytfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hra'] theme:Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >prep_to [lemma='hra'] themetSe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='they'] Generic_entityt8e2: trigger-arg-path: Binding >poss [lemma='they'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hra'] Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss themet:e2: trigger-arg-path: binding:Binding >poss Generic_entitytJe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='they'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hra'] theme:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='calmodulin'] Gene_or_gene_producttAe2: trigger-arg-path: binding >poss [lemma='they'] Generic_entitytAe2: trigger-arg-path: Binding >poss [lemma='they'] Generic_entityt8e1: trigger-arg-path: binds >prep_to [lemma='hra'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='calmodulin'] themetGe1: trigger-arg-path: binds >prep_to [lemma='hra'] Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_to [lemma='hra'] Gene_or_gene_producttRe1: trigger-arg-path: binds >nsubj [lemma='calmodulin'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds >prep_to [lemma='hra'] theme:Gene_or_gene_productt@e2: trigger-arg-path: binding:Binding >poss [lemma='they'] themetNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='calmodulin'] themet8e2: trigger-arg-path: binding >poss [lemma='they'] themet5interceding-tokens-full-span: and KRas and suppressestEe1: trigger-arg-path: binds:Binding >nsubj [lemma='calmodulin'] themet=e1: trigger-arg-path: binds >nsubj [lemma='calmodulin'] themetGe2: trigger-arg-path: binding >poss [lemma='they'] theme:Generic_entitytTe1: trigger-arg-path: Binding >nsubj [lemma='calmodulin'] theme:Gene_or_gene_productt;e2: trigger-arg-path: lemmatizedTrigger=binding >poss themet)e2: trigger-arg-path: binding >poss themetOe1: trigger-arg-path: Binding >prep_to [lemma='hra'] theme:Gene_or_gene_producttZe1: trigger-arg-path: binds:Binding >nsubj [lemma='calmodulin'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_to [lemma='hra'] themetke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='calmodulin'] theme:Gene_or_gene_producttqtrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='suppress'] >dobj [lemma='binding'] e2:binding:BindingtGe2: trigger-arg-path: Binding >poss [lemma='they'] theme:Generic_entityt(interceding-token ngrams: and suppressest?e1: trigger-arg-path: Binding >nsubj [lemma='calmodulin'] themetRe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss theme:Generic_entitytIe2: trigger-arg-path: binding:Binding >poss [lemma='they'] Generic_entitytLtrigger-to-trigger-path: e1:binds:Binding >conj_and >dobj e2:binding:Bindingt[e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='they'] Generic_entityt!shortest-path: dobj >posst"interceding-token ngrams: KRas andt1e2: trigger-arg-path: binding:Binding >poss themetUe1: trigger-arg-path: binds:Binding >prep_to [lemma='hra'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='calmodulin'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='they'] theme:Generic_entitytLe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss Generic_entityt$interceding-token ngrams: suppressestJe2: trigger-arg-path: lemmatizedTrigger=binding >poss theme:Generic_entitytee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='calmodulin'] Gene_or_gene_productt"interceding-token ngrams: and KRastOe2: trigger-arg-path: binding:Binding >poss [lemma='they'] theme:Generic_entitytUshortest-path: dobj [lemma='binding'] >poss [lemma='they']t-interceding-token ngrams: KRas and suppressestinterceding-token ngrams: KRastae2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='they'] theme:Generic_entitytNe1: trigger-arg-path: negatively regulates nsubj Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_regulation nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: bound RAS totVe2: trigger-arg-path: Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] themet~e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: regulates RAS activityt&e1: ents2Label-mention-ngram: inactivetnsubj [lemma='neurofibromin'] controllert'e1: ents2Label-mention-ngram: bound RAStke2: trigger-arg-path: Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj [lemma='neurofibromin'] controller:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >ccomp >nsubj >prep_to controlledtce2: trigger-arg-path: bound >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: hydrolysis of activet6e1: ents2Label-mention-ngram: negatively regulates RASt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlledt*e1: args2Role-mention-ngram: GTP bound RAStDe1: trigger-arg-path: negatively regulates nsubj controllert&e1: args2Role-mention-ngram: of activet?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to Bindingt]e2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt.e1: ents2Label-mention-ngram: accelerating thet%e1: args2Role-mention-ngram: activityt$e1: ents2Label-mention-ngram: RAS totye1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlledt+e1: args2Role-mention-ngram: the hydrolysistKe2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet2e1: args2Role-mention-ngram: CONTROLLER negativelytze2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: negatively regulates RASt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj [lemma='neurofibromin'] Gene_or_gene_producttqe2: trigger-arg-path: bound:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: inactive CONTROLLEDt?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj [lemma='neurofibromin'] controllert-e1: ents2Label-mention-ngram: by acceleratingt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT negativelyt8e1: args2Role-mention-ngram: accelerating the hydrolysistee2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] themet\e2: trigger-arg-path: bound:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] themetRe2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familyt-e1: ents2Label-mention-ngram: RAS activity bytSe2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet)e1: ents2Label-mention-ngram: activity byt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlled:Bindingt*e1: ents2Label-mention-ngram: bound RAS tot1e1: args2Role-mention-ngram: hydrolysis of activetee2: trigger-arg-path: Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Gene_or_gene_productt,e1: args2Role-mention-ngram: RAS to inactivetve1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to Bindingtbe1: trigger-arg-path: negatively regulates:Negative_regulation nsubj Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >ccomp >nsubj >prep_to Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlled:Bindingt@e2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj themet*e1: args2Role-mention-ngram: of active GTPtoe1: trigger-arg-path: negatively regulates nsubj [lemma='neurofibromin'] controllert6shortest-path: prepc_by >ccomp >nsubj >prep_oft?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlled:BindingtTe2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:FamilytIe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj Familyt+e1: ents2Label-mention-ngram: hydrolysis oft?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] BindingtNe2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] FamilytAe1: ents2Label-mention-ngram: inactive GENE_OR_GENE_PRODUCT boundt*e1: ents2Label-mention-ngram: RAS activitytMe1: trigger-arg-path: Negative_regulation nsubj Gene_or_gene_productt.e1: ents2Label-mention-ngram: active GTP boundtTe2: trigger-arg-path: bound >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] themet?e1: trigger-arg-path: negatively regulates:Negative_regulation nsubj [lemma='neurofibromin'] controllert#e1: args2Role-mention-ngram: RAS tot?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] Bindingt-e1: args2Role-mention-ngram: accelerating thet2e2: trigger-arg-path: Binding >ccomp >nsubj Familyt7e2: trigger-arg-path: bound:Binding >ccomp >nsubj themet?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound SHAREDt)e1: args2Role-mention-ngram: acceleratingtXe1: trigger-arg-path: negatively regulates:Negative_regulation nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlled:Bindingt1e1: ents2Label-mention-ngram: by accelerating thet>e2: trigger-arg-path: bound:Binding >ccomp >nsubj theme:Familytde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet'e1: ents2Label-mention-ngram: of activetTe2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt?trigger-to-trigger-path: e1:negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] e2:bound:Bindingt;e1: ents2Label-mention-ngram: inactive GENE_OR_GENE_PRODUCTt\e2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] themet(e1: args2Role-mention-ngram: activity bytte2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Gene_or_gene_productt?shortest-path: prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp']t?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlledt.e1: args2Role-mention-ngram: the hydrolysis oft+e1: ents2Label-mention-ngram: regulates RAStxe1: trigger-arg-path: Negative_regulation nsubj [lemma='neurofibromin'] Gene_or_gene_producttie2: trigger-arg-path: bound >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] themetee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familyt-e1: ents2Label-mention-ngram: RAS to inactivetntrigger-to-trigger-path: e1:negatively regulates:Negative_regulation prepc_by >ccomp e2:bound:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: to inactivetke2: trigger-arg-path: bound:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Gene_or_gene_producttYe1: trigger-arg-path: negatively regulates nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlled:Bindingt>e1: ents2Label-mention-ngram: to inactive GENE_OR_GENE_PRODUCTtHe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj themet-e1: args2Role-mention-ngram: active GTP boundtje1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] Bindingt1e2: trigger-arg-path: Binding >ccomp >nsubj themetOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlledt,e1: args2Role-mention-ngram: by acceleratingt(e1: ents2Label-mention-ngram: active GTPtse1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='neurofibromin'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: GTP bound RASt,e1: ents2Label-mention-ngram: the hydrolysist&e1: args2Role-mention-ngram: regulatestke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:FamilytZe2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familyt8e2: trigger-arg-path: Binding >ccomp >nsubj theme:Familyt8e2: trigger-arg-path: bound:Binding >ccomp >nsubj Familyt6e2: trigger-arg-path: bound >ccomp >nsubj theme:Familyt6e1: ents2Label-mention-ngram: activity by acceleratingt|e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Gene_or_gene_productt!e1: trigger: negatively regulatestye1: trigger-arg-path: negatively regulates nsubj [lemma='neurofibromin'] Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlled:Bindingt/e2: trigger-arg-path: bound >ccomp >nsubj themetUe1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj controllert(e1: ents2Label-mention-ngram: negativelyt0e2: trigger-arg-path: bound >ccomp >nsubj FamilytGe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT negatively regulatest0e1: args2Role-mention-ngram: by accelerating thet,e1: args2Role-mention-ngram: RAS activity bytGe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj theme:Familyt2e1: ents2Label-mention-ngram: negatively regulatest*e1: args2Role-mention-ngram: hydrolysis oftXe1: trigger-arg-path: Negative_regulation nsubj controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: hydrolysist(e1: args2Role-mention-ngram: to inactivetbe1: trigger-arg-path: negatively regulates prepc_by >ccomp >ccomp >nsubj >prep_to Bindingt?e1: trigger-arg-path: negatively regulates nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: active GTPtce2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='ra'] theme:Familytee1: trigger-arg-path: negatively regulates prepc_by >ccomp >ccomp >nsubj >prep_to controlledt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttCe1: trigger-arg-path: Negative_regulation nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlledt'e1: ents2Label-mention-ngram: regulatest?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='neurofibromin'] controllert?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >ccomp [lemma='bind'] >nsubj [lemma='ra'] >prep_to [lemma='gdp'] controlled:Bindingtme1: trigger-arg-path: negatively regulates prepc_by >ccomp >ccomp >nsubj >prep_to controlled:Bindingt5e1: args2Role-mention-ngram: activity by acceleratingtle1: trigger-arg-path: Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlled:Bindingt?e1: trigger-arg-path: negatively regulates:Negative_regulation nsubj [lemma='neurofibromin'] Gene_or_gene_producttde1: trigger-arg-path: Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to controlledtae1: trigger-arg-path: Negative_regulation prepc_by >ccomp >ccomp >nsubj >prep_to Bindingtme2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] themetme1: trigger-arg-path: negatively regulates:Negative_regulation nsubj controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: acceleratingt+e1: ents2Label-mention-ngram: of active GTPt'e1: args2Role-mention-ngram: negativelyt3e1: args2Role-mention-ngram: to inactive CONTROLLEDte1: CONTROLLED: 6t~e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >ccomp >nsubj >prep_to controlled:Bindingt%e1: args2Role-mention-ngram: inactivet_e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj Gene_or_gene_productt)e1: args2Role-mention-ngram: RAS activityt3e1: args2Role-mention-ngram: regulates RAS activitytAe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj Familyt*e1: args2Role-mention-ngram: regulates RASt'e1: args2Role-mention-ngram: hydrolysist&e1: args2Role-mention-ngram: bound RAStLe2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='ra'] Familytie1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation nsubj controllert?e1: trigger-arg-path: Negative_regulation nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: accelerating the hydrolysist1e1: args2Role-mention-ngram: negatively regulatest/e1: ents2Label-mention-ngram: the hydrolysis oft#interceding-token ngrams: with TSC1t?trigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_with [lemma='tsc1'] >vmod [lemma='abolish'] >dobj [lemma='effect'] >prep_of [lemma='complex'] e2:complex:Bindingt&interceding-token ngrams: the negativet(interceding-token ngrams: abolishing thetinterceding-token ngrams: TSC1t+interceding-token ngrams: regulatory effectt4interceding-token ngrams: negative regulatory effectt1interceding-token ngrams: abolishing the negativet1interceding-token ngrams: the negative regulatoryt interceding-token ngrams: , thust$interceding-token ngrams: regulatoryt%interceding-token ngrams: TSC1 , thust interceding-token ngrams: TSC1 ,t?interceding-tokens-full-span: destabilizes TSC2 and disrupts its interaction with TSC1 , thus abolishing the negative regulatory effect oft+interceding-token ngrams: , thus abolishingt-interceding-token ngrams: negative regulatoryt=shortest-path: prep_with >vmod >dobj >prep_of >nnt-interceding-token ngrams: thus abolishing thet$interceding-token ngrams: abolishingt interceding-token ngrams: effectt.interceding-token ngrams: regulatory effect oft?shortest-path: prep_with [lemma='tsc1'] >vmod [lemma='abolish'] >dobj [lemma='effect'] >prep_of [lemma='complex'] >nn [lemma='tsc2']t)interceding-token ngrams: thus abolishingt/interceding-token ngrams: interaction with TSC1tytrigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_with >vmod >dobj >prep_of e2:complex:Bindingt#interceding-token ngrams: effect oft%interceding-token ngrams: with TSC1 ,tpe2: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] FamilytGe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppresses activatedt^e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn Familytge1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ra'] Familyt:e1: trigger-arg-path: complex:Binding nn theme:Familyt|e1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllertTe1: trigger-arg-path: complex:Binding nn [lemma='ra'] themetEe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn themetee2: trigger-arg-path: Positive_activation nsubj >prep_of controller:Gene_or_gene_producttLe1: trigger-arg-path: Binding nn [lemma='ra'] themetMe1: trigger-arg-path: Binding nn [lemma='raf'] themetZe2: trigger-arg-path: suppresses activated:Positive_activation nn controlled:Familyt?shortest-path: advcl [lemma='suppress'] >nsubj [lemma='reduction'] >prep_of [lemma='sur-8']t!e2: trigger: suppresses activatedt2e1: trigger-arg-path: complex nn theme:Familythtrigger-to-trigger-path: e1:complex:Binding advcl e2:suppresses activated:Positive_activationtte1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='raf'] theme:Gene_or_gene_productt9e2: ents2Label-mention-ngram: suppresses activated SHAREDt?e2: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_productt=e1: trigger-arg-path: lemmatizedTrigger=complex nn themetFe2: trigger-arg-path: suppresses activated nn controlled:Familyt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppressest&interceding-token ngrams: reduction oftve1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] Gene_or_gene_productt\e2: trigger-arg-path: suppresses activated nn [lemma='ra'] Familytfe2: trigger-arg-path: Positive_activation nn [lemma='ra'] controlled:Familyt?e2: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt`e2: trigger-arg-path: suppresses activated nn [lemma='ra'] controlledtge1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] themetoe2: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:Familytge2: trigger-arg-path: suppresses activated nn [lemma='ra'] controlled:Familytze2: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: suppresses activated nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_producttQe2: trigger-arg-path: suppresses activated nsubj >prep_of controllert>e2: trigger-arg-path: Positive_activation nn controlledtbe1: trigger-arg-path: complex nn [lemma='raf'] theme:Gene_or_gene_productt{e2: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] controlled:Familyt(e2: ents2Label-mention-ngram: suppressest?e2: trigger-arg-path: suppresses activated nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt'e2: args2Role-mention-ngram: suppressestUe1: trigger-arg-path: complex:Binding nn [lemma='ra'] Familytbe1: trigger-arg-path: Binding nn [lemma='raf'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=suppress activate nn controlled:Familyt3e1: trigger-arg-path: complex:Binding nn themetJe2: trigger-arg-path: lemmatizedTrigger=suppress activate nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert_e2: trigger-arg-path: Positive_activation nn [lemma='ra'] controlledt1e2: args2Role-mention-ngram: suppresses activatedtoe2: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] controlledtue2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of controller:Gene_or_gene_producttfe2: trigger-arg-path: suppresses activated nsubj >prep_of controller:Gene_or_gene_productt4e1: trigger-arg-path: complex:Binding nn FamilytSe2: trigger-arg-path: suppresses activated:Positive_activation nn controlledt:e1: trigger-arg-path: complex nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] controlledt?e2: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_producttOe2: trigger-arg-path: suppresses activated:Positive_activation nn Familyt=e1: ents2Label-mention-ngram: SHARED and GENE_OR_GENE_PRODUCTt2e2: ents2Label-mention-ngram: suppresses activatedtRe1: trigger-arg-path: lemmatizedTrigger=complex nn theme:Gene_or_gene_productt+interceding-token ngrams: whereas reductiont`e2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of controllertne1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='raf'] Gene_or_gene_producttte2: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] controlledt#interceding-token ngrams: reductiont?e2: trigger-arg-path: suppresses activated nn controlledtEe2: trigger-arg-path: Positive_activation nn controlled:FamilytUe1: trigger-arg-path: complex:Binding nn [lemma='raf'] themetTe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] controlled:Familytje1: trigger-arg-path: complex:Binding nn [lemma='raf'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn controlled:Familytme1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ra'] theme:FamilytDe1: trigger-arg-path: lemmatizedTrigger=complex nn theme:Familyt:e2: trigger-arg-path: Positive_activation nn Familytke2: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] Familyte2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] FamilytLe1: trigger-arg-path: complex nn [lemma='ra'] themetLe1: trigger-arg-path: lemmatizedTrigger=complex nn Gene_or_gene_productt\e1: trigger-arg-path: Binding nn [lemma='raf'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_productt.interceding-token ngrams: whereas reduction oftPe2: trigger-arg-path: Positive_activation nsubj >prep_of controllertfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ra'] themet@e1: trigger-arg-path: complex nn theme:Gene_or_gene_producttHe1: trigger-arg-path: complex:Binding nn theme:Gene_or_gene_producttde1: trigger-arg-path: complex:Binding nn [lemma='raf'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of controllert2e2: args2Role-mention-ngram: CONTROLLER suppressestZe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllertve2: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] controlled:Familyt_e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] FamilytZe2: trigger-arg-path: Positive_activation nsubj >prep_of Gene_or_gene_productt%interceding-token ngrams: formation ,t;e2: trigger-arg-path: suppresses activated nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] themet[e1: trigger-arg-path: complex:Binding nn [lemma='ra'] theme:Familytee2: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of controllert?trigger-to-trigger-path: e1:complex:Binding advcl [lemma='suppress'] e2:suppresses activated:Positive_activationt\e1: trigger-arg-path: complex nn [lemma='raf'] Gene_or_gene_productt?e2: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllertSe1: trigger-arg-path: complex nn [lemma='ra'] theme:Familytnn Gene_or_gene_productt>interceding-tokens-full-span: formation , whereas reduction oft[e2: trigger-arg-path: Positive_activation nn [lemma='ra'] Familyt[e2: trigger-arg-path: suppresses activated nsubj >prep_of Gene_or_gene_producttMe1: trigger-arg-path: complex nn [lemma='ra'] Familyt,e1: trigger-arg-path: complex nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of controller:Gene_or_gene_productt-interceding-token ngrams: , whereas reductiont_e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='raf'] themetSe1: trigger-arg-path: Binding nn [lemma='ra'] theme:Familyt>e1: trigger-arg-path: lemmatizedTrigger=complex nn Familyt+e1: trigger-arg-path: complex nn themet/shortest-path: advcl >nsubj >prep_oftMe1: trigger-arg-path: Binding nn [lemma='ra'] Familyt-interceding-token ngrams: formation , whereastNe2: trigger-arg-path: lemmatizedTrigger=suppress activate nn controlledtnsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert?e2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_producttMe1: trigger-arg-path: complex nn [lemma='raf'] themetFe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn Familytbe2: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn controlledt*e2: ents2Label-mention-ngram: versus othertTe2: trigger-arg-path: disrupt nn [lemma='mcp110'] controllertTe1: trigger-arg-path: disruption:Negative_regulation >nn [lemma='mcp110'] controllert-interceding-token ngrams: but the selectivityt/e1: ents2Label-mention-ngram: SHARED disruptiont8e1: trigger-arg-path: Negative_regulation >nn controllert)interceding-token ngrams: the selectivitytUe2: trigger-arg-path: Negative_regulation conj_but >nsubjpass >prep_oft`e2: trigger-arg-path: Negative_regulation nn controller:Gene_or_gene_productt/e1: trigger-arg-path: disruption >nn controllert$e2: args2Role-mention-ngram: disruptt(e1: ents2Label-mention-ngram: disruptiontKe2: trigger-arg-path: Negative_regulation nn [lemma='mcp110'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: to disrupt interactionste2: trigger: disruptt?trigger-to-trigger-path: e1:disruption:Negative_regulation conj_but >nsubjpass >prep_of >vmod e2:disrupt:Negative_regulationt1e2: ents2Label-mention-ngram: versus other GTPasetge1: trigger-arg-path: lemmatizedTrigger=disruption >nn [lemma='mcp110'] controller:Gene_or_gene_productt^e1: trigger-arg-path: disruption:Negative_regulation >nn [lemma='mcp110'] Gene_or_gene_producttCe1: trigger-arg-path: disruption:Negative_regulation >nn controllertVe1: trigger-arg-path: lemmatizedTrigger=disruption >nn controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: to disruptt2e2: ents2Label-mention-ngram: disrupt interactionst(interceding-token ngrams: selectivity oft'e2: args2Role-mention-ngram: to disruptt'e1: args2Role-mention-ngram: disruptiontfe1: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn [lemma='mcp110'] controllert6interceding-tokens-full-span: , but the selectivity oft,e2: ents2Label-mention-ngram: GTPase and RBDtfe2: trigger-arg-path: lemmatizedTrigger=disrupt nn [lemma='mcp110'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn [lemma='mcp110'] controller:Gene_or_gene_producttJe1: trigger-arg-path: disruption >nn [lemma='mcp110'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: other GTPasetJe2: trigger-arg-path: lemmatizedTrigger=disrupt nn controller:Gene_or_gene_producttWe2: trigger-arg-path: disrupt:Negative_regulation nn [lemma='mcp110'] controllert,e1: ents2Label-mention-ngram: the SHARED andthe2: trigger-arg-path: disrupt:Negative_regulation nn controllert.e2: ents2Label-mention-ngram: other GTPase andtSe1: trigger-arg-path: Negative_regulation >nn [lemma='mcp110'] Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=disruption >nn Gene_or_gene_productt!interceding-token ngrams: but thetUe1: trigger-arg-path: disruption >nn [lemma='mcp110'] controller:Gene_or_gene_productt@e1: trigger-arg-path: disruption >nn [lemma='mcp110'] controllertze2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation nn Gene_or_gene_productt9e1: trigger-arg-path: disruption >nn Gene_or_gene_productt8e2: trigger-arg-path: disrupt nn controller:Gene_or_gene_producttDe1: trigger-arg-path: disruption >nn controller:Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER disruptiont?shortest-path: conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110']t2e2: args2Role-mention-ngram: CONTROLLER to disruptt#interceding-token ngrams: , but thetTe2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation nn Gene_or_gene_producttIe2: trigger-arg-path: disrupt nn controllertee2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation nn [lemma='mcp110'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: to disrupt CONTROLLEDt.e1: args2Role-mention-ngram: disruption of thetLe2: trigger-arg-path: disrupt:Negative_regulation conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110'] >vmod [lemma='disrupt'] e2:disrupt:Negative_regulationt*e2: args2Role-mention-ngram: CONTROLLER tot\e1: trigger-arg-path: lemmatizedTrigger=disruption >nn [lemma='mcp110'] Gene_or_gene_producttMe1: trigger-arg-path: disruption:Negative_regulation >nn Gene_or_gene_producttSe2: trigger-arg-path: disrupt:Negative_regulation dobj [lemma='phosphorylation'] Phosphorylationt;e1: trigger-arg-path: inhibits >nsubj >nn controller:FamilytRe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: FAMILY inhibitiontJe2: trigger-arg-path: heterodimer >nn [lemma='c-jun'] Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER inhibitiontOe1: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn controller:Familyt[e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='jdp2'] Gene_or_gene_productt;e2: trigger-arg-path: heterodimer >nn [lemma='c-jun'] themetSe1: trigger-arg-path: inhibits:Positive_regulation >dobj controlled:Phosphorylationt`e1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn controller:FamilytIe2: trigger-arg-path: heterodimer >nn [lemma='jdp2'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='c-jun'] themet(interceding-token ngrams: dispersing thetEe2: trigger-arg-path: Binding >nn [lemma='jdp2'] Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controllert7e1: args2Role-mention-ngram: CONTROLLER inhibition alsot]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familyt~e1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtBe2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT heterodimertHe2: trigger-arg-path: heterodimer:Binding >nn theme:Gene_or_gene_productt:e2: trigger-arg-path: heterodimer >nn [lemma='jdp2'] themet?shortest-path: dep [lemma='disperse'] >dobj [lemma='heterodimer'] >nn [lemma='c-jun']tTe1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj controlledtMe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='c-jun'] themet3e2: trigger-arg-path: heterodimer:Binding >nn themetbe1: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationtie2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='jdp2'] theme:Gene_or_gene_productte2: trigger: heterodimert@e2: trigger-arg-path: heterodimer >nn theme:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn themetne1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj [lemma='phosphorylation'] controlledtHe1: trigger-arg-path: inhibits:Positive_regulation >dobj Phosphorylationt)e2: ents2Label-mention-ngram: heterodimertKe2: trigger-arg-path: Binding >nn [lemma='jdp2'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='jdp2'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='c-jun'] Gene_or_gene_productt:e2: trigger-arg-path: heterodimer >nn Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='jdp2'] themetne1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familyt(e2: args2Role-mention-ngram: heterodimert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:Familythe1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:FamilytRe2: trigger-arg-path: heterodimer:Binding >nn [lemma='c-jun'] Gene_or_gene_productt-interceding-token ngrams: thus dispersing thetFe1: trigger-arg-path: Positive_regulation >nsubj >nn controller:FamilytQe2: trigger-arg-path: heterodimer:Binding >nn [lemma='jdp2'] Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllertYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn controllertDe1: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn Familytbe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='c-jun'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj controlled:Phosphorylationt(shortest-path: dep >dobj >nnt.e2: args2Role-mention-ngram: THEME heterodimert3interceding-tokens-full-span: , thus dispersing thetTe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='jdp2'] themetje1: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllertRe1: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familytge1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllertUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj >nn Familyt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT heterodimert0e1: trigger-arg-path: inhibits >nsubj >nn Familytme1: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtXe2: trigger-arg-path: heterodimer:Binding >nn [lemma='c-jun'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Familytqe1: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:FamilytTe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn Gene_or_gene_productt+interceding-token ngrams: , thus dispersingt7e2: trigger-arg-path: Binding >nn [lemma='c-jun'] themetVe1: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllert;e1: trigger-arg-path: Positive_regulation >nsubj >nn Familyt4e1: ents2Label-mention-ngram: FAMILY inhibition alsot=e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn themet?trigger-to-trigger-path: e1:inhibits:Positive_regulation >dep [lemma='disperse'] >dobj [lemma='heterodimer'] e2:heterodimer:BindingtHe1: trigger-arg-path: inhibits:Positive_regulation >nsubj >nn controllert\e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='c-jun'] Gene_or_gene_producttCe1: trigger-arg-path: inhibits:Positive_regulation >dobj controlledtLe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='jdp2'] themetWe2: trigger-arg-path: heterodimer:Binding >nn [lemma='jdp2'] theme:Gene_or_gene_productt$interceding-token ngrams: dispersingtBe2: trigger-arg-path: heterodimer:Binding >nn [lemma='jdp2'] themet2e2: args2Role-mention-ngram: and THEME heterodimertfe1: trigger-arg-path: inhibits:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familytae2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='jdp2'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='c-jun'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='c-jun'] Gene_or_gene_productt)interceding-token ngrams: thus dispersingtAe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn FamilytZtrigger-to-trigger-path: e1:inhibits:Positive_regulation >dep >dobj e2:heterodimer:Bindingt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] controllert]e1: trigger-arg-path: inhibits:Positive_regulation >dobj [lemma='phosphorylation'] controlledtwe1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >nsubj [lemma='inhibition'] >nn [lemma='ra'] FamilytLe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn Gene_or_gene_producttOe2: trigger-arg-path: heterodimer >nn [lemma='jdp2'] theme:Gene_or_gene_productt4e1: trigger-arg-path: inhibits >nsubj >nn controllertCe2: trigger-arg-path: heterodimer:Binding >nn [lemma='c-jun'] themet+e2: trigger-arg-path: heterodimer >nn themetPe2: trigger-arg-path: heterodimer >nn [lemma='c-jun'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='inhibition'] >nn [lemma='ra'] Familyt]e1: trigger-arg-path: inhibits >nsubj [lemma='inhibition'] >nn [lemma='ra'] controller:FamilytYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_regulation >dobj PhosphorylationtBe2: trigger-arg-path: heterodimer:Binding >nn Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='c-jun'] theme:Gene_or_gene_productt^e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='smad2'] Gene_or_gene_productt)e2: args2Role-mention-ngram: requires thet8e2: ents2Label-mention-ngram: acetylation of nucleosomaltge2: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst,e1: ents2Label-mention-ngram: histone H3 andtqtrigger-to-trigger-path: e1:mediated:Positive_regulation >ccomp [lemma='require'] e2:requires:Positive_regulationt1e1: ents2Label-mention-ngram: SHARED requires thet e1: ents2Label-mention-ngram: H3t1e1: ents2Label-mention-ngram: nucleosomal histonetYe2: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] BioProcesstSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] controllertee1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='smad2'] controllert\e2: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] BioProcesstOe2: trigger-arg-path: requires:Positive_regulation >nsubj controller:BioProcesst,e2: ents2Label-mention-ngram: histone H3 andt$e1: ents2Label-mention-ngram: H3 andtAe2: trigger-arg-path: lemmatizedTrigger=require >nsubj controllertJe1: trigger-arg-path: mediated >nsubj [lemma='smad2'] Gene_or_gene_productt@e1: trigger-arg-path: mediated >nsubj [lemma='smad2'] controllertDe2: trigger-arg-path: requires:Positive_regulation >nsubj BioProcesst,e1: ents2Label-mention-ngram: of nucleosomalt e2: ents2Label-mention-ngram: H3t4e2: ents2Label-mention-ngram: nucleosomal histone H3t;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediatedt-e1: ents2Label-mention-ngram: SHARED requirestHe2: trigger-arg-path: requires >nsubj [lemma='transcription'] controllertUe2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj controllertfe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='smad2'] controller:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=require >nsubj controller:BioProcesst`e2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj controller:BioProcesst1e2: ents2Label-mention-ngram: nucleosomal histonet6e1: ents2Label-mention-ngram: requires the acetylationtme2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] controllert,e2: ents2Label-mention-ngram: of nucleosomaltKe1: trigger-arg-path: Positive_regulation >nsubj [lemma='smad2'] controllertze1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='smad2'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: H3 and SHAREDtSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] BioProcesstAe2: trigger-arg-path: lemmatizedTrigger=require >nsubj BioProcesst8e1: ents2Label-mention-ngram: acetylation of nucleosomaltoe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='smad2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] controller:BioProcesst$e2: ents2Label-mention-ngram: H3 andt%e2: ents2Label-mention-ngram: histonet*e1: ents2Label-mention-ngram: requires thetHe2: trigger-arg-path: requires >nsubj [lemma='transcription'] BioProcesst(e2: ents2Label-mention-ngram: histone H3t)e2: ents2Label-mention-ngram: nucleosomaltUe2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj BioProcesst1e2: ents2Label-mention-ngram: SHARED requires thet4e1: ents2Label-mention-ngram: of nucleosomal histonetTe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='smad2'] controllert^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst6e2: ents2Label-mention-ngram: requires the acetylationtme2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] BioProcesst[e1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='smad2'] Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER requirest%e1: ents2Label-mention-ngram: histonet-e1: ents2Label-mention-ngram: the acetylationt4e1: ents2Label-mention-ngram: nucleosomal histone H3t0e2: trigger-arg-path: requires >nsubj controllertSe2: trigger-arg-path: requires >nsubj [lemma='transcription'] controller:BioProcesst4e2: args2Role-mention-ngram: CONTROLLER requires thet+e1: ents2Label-mention-ngram: H3 and SHAREDt)e1: ents2Label-mention-ngram: nucleosomaltUe1: trigger-arg-path: Positive_regulation >nsubj [lemma='smad2'] Gene_or_gene_producttie1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='smad2'] controller:Gene_or_gene_producttFe2: trigger-arg-path: Positive_regulation >nsubj controller:BioProcesst(e1: ents2Label-mention-ngram: histone H3t*e2: ents2Label-mention-ngram: requires thetBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] controllertUe1: trigger-arg-path: mediated >nsubj [lemma='smad2'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: mediated SHARED requirest4e2: args2Role-mention-ngram: requires the CONTROLLEDt;e2: trigger-arg-path: requires >nsubj controller:BioProcesst_shortest-path: ccomp [lemma='require'] >nsubj [lemma='transcription']t\e2: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] controllert0e1: ents2Label-mention-ngram: the acetylation oft_trigger-to-trigger-path: e1:mediated:Positive_regulation >ccomp e2:requires:Positive_regulationt0e2: trigger-arg-path: requires >nsubj BioProcesstxe2: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst+e2: ents2Label-mention-ngram: and SHARED byt;e2: trigger-arg-path: Positive_regulation >nsubj BioProcesstDe2: trigger-arg-path: requires:Positive_regulation >nsubj controllertQe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='smad2'] controllert-e2: ents2Label-mention-ngram: SHARED requirest4e2: ents2Label-mention-ngram: of nucleosomal histonet`e1: trigger-arg-path: Positive_regulation >nsubj [lemma='smad2'] controller:Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >nsubj >prep_of controlledt?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Bindingt?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >nsubj >prep_of controlled:Bindingt.e1: ents2Label-mention-ngram: of active SHAREDt.e1: args2Role-mention-ngram: active CONTROLLEDt[e1: trigger-arg-path: negatively regulates prepc_by >ccomp >nsubj >prep_of Bindingt1e1: args2Role-mention-ngram: of active CONTROLLEDtoe1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >nsubj >prep_of Bindingt?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlled:Bindingt?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlled:Bindingt]e1: trigger-arg-path: Negative_regulation prepc_by >ccomp >nsubj >prep_of controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by >ccomp >nsubj >prep_of BindingtZe1: trigger-arg-path: Negative_regulation prepc_by >ccomp >nsubj >prep_of Bindingtee1: trigger-arg-path: Negative_regulation prepc_by >ccomp >nsubj >prep_of controlled:Bindingt^e1: trigger-arg-path: negatively regulates prepc_by >ccomp >nsubj >prep_of controlledtle1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >nsubj >prep_of Bindingtze1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >nsubj >prep_of controlled:Bindingt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Bindingtwe1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >nsubj >prep_of controlled:Bindingt1e1: ents2Label-mention-ngram: active SHARED boundt?e1: trigger-arg-path: Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlled:Bindingt?e1: trigger-arg-path: negatively regulates prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlledtoe1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by >ccomp >nsubj >prep_of controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlled:Bindingtre1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by >ccomp >nsubj >prep_of controlledt?e1: trigger-arg-path: negatively regulates:Negative_regulation prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >prep_of [lemma='gtp'] controlled:Bindingtfe1: trigger-arg-path: negatively regulates prepc_by >ccomp >nsubj >prep_of controlled:BindingtMe2: trigger-arg-path: complex:Binding >nn [lemma='sos1'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='grb2'] themet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sos1'] theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='grb2'] themetSe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='grb2'] controllertPe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='grb2'] controllert]e1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='grb2'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: the membranet-e1: ents2Label-mention-ngram: SHARED recruitstPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='grb2'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sos1'] themetEe2: trigger-arg-path: complex >nn [lemma='grb2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='grb2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='grb2'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='grb2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: recruits >nsubj [lemma='grb2'] controllertye1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='grb2'] controller:Gene_or_gene_productt%interceding-tokens-full-span: to formt6e2: trigger-arg-path: complex >nn [lemma='grb2'] themet_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sos1'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='sos1'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='grb2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sos1'] Gene_or_gene_productt?trigger-to-trigger-path: e1:recruits:Positive_regulation >prep_to [lemma='membrane'] >vmod [lemma='form'] >dobj [lemma='complex'] e2:complex:BindingtJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='grb2'] controllert>e2: trigger-arg-path: complex:Binding >nn [lemma='sos1'] themet6e2: trigger-arg-path: Binding >nn [lemma='sos1'] themetde1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='grb2'] controllertSe2: trigger-arg-path: complex:Binding >nn [lemma='sos1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='grb2'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: to the membranetee1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='grb2'] controller:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='sos1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sos1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='grb2'] theme:Gene_or_gene_productthe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='grb2'] controller:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='grb2'] theme:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='grb2'] Gene_or_gene_producttIe1: trigger-arg-path: recruits >nsubj [lemma='grb2'] Gene_or_gene_productt`trigger-to-trigger-path: e1:recruits:Positive_regulation >prep_to >vmod >dobj e2:complex:BindingtEe2: trigger-arg-path: Binding >nn [lemma='sos1'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='grb2'] Gene_or_gene_producttTe1: trigger-arg-path: recruits >nsubj [lemma='grb2'] controller:Gene_or_gene_productt.shortest-path: prep_to >vmod >dobj >nnt?shortest-path: prep_to [lemma='membrane'] >vmod [lemma='form'] >dobj [lemma='complex'] >nn [lemma='grb2']tHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='grb2'] themet6e2: trigger-arg-path: complex >nn [lemma='sos1'] themetne1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='grb2'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sos1'] themetKe2: trigger-arg-path: Binding >nn [lemma='sos1'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED recruits SHAREDtMe2: trigger-arg-path: complex:Binding >nn [lemma='grb2'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='grb2'] theme:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='grb2'] controller:Gene_or_gene_producttPe1: trigger-arg-path: bound:Binding >prep_to [lemma='grb2'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind prep_to Gene_or_gene_productt:e1: trigger-arg-path: bound prep_to theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='grb2'] Gene_or_gene_productt)e2: trigger-arg-path: Binding prep_to [lemma='grb2'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding prep_to [lemma='grb2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: bound >prep_to theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: Gab1tJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='grb2'] themet+e2: ents2Label-mention-ngram: or Gab1 boundt@e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to themetOe1: trigger-arg-path: bound e2: trigger-arg-path: Binding prep_to [lemma='grb2'] themet*e1: trigger-arg-path: bound >prep_to themetOe2: trigger-arg-path: bound prep_to themet+e1: ents2Label-mention-ngram: or Gab1 boundt;e2: trigger-arg-path: Binding >prep_to [lemma='grb2'] themet@e1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='grb2'] Gene_or_gene_producttprep_to [lemma='grb2'] themet"e1: ents2Label-mention-ngram: Gab1t8e1: trigger-arg-path: Binding prep_to [lemma='grb2'] themetSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding e1: trigger-arg-path: bound:Binding prep_to Gene_or_gene_productt2e2: trigger-arg-path: bound:Binding >prep_to themet-e1: ents2Label-mention-ngram: bound to SHAREDtKe1: trigger-arg-path: Binding prep_to [lemma='grb2'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: Gab1tNe1: trigger-arg-path: bound >prep_to [lemma='grb2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='grb2'] theme:Gene_or_gene_producttprep_to [lemma='grb2'] Gene_or_gene_productt9e1: trigger-arg-path: bound >prep_to Gene_or_gene_producttGe1: trigger-arg-path: bound:Binding >prep_to theme:Gene_or_gene_productt9e2: trigger-arg-path: bound >prep_to [lemma='grb2'] themetDe1: trigger-arg-path: bound:Binding prep_to [lemma='grb2'] Gene_or_gene_productt6e1: trigger-arg-path: bound prep_to Gene_or_gene_productt$e2: args2Role-mention-ngram: or Gab1t>e2: trigger-arg-path: bound:Binding prep_to [lemma='grb2'] theme:Gene_or_gene_producttWe2: trigger-arg-path: bound:Binding prep_to theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='grb2'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding e1: trigger-arg-path: Binding prep_to [lemma='grb2'] themet(e1: ents2Label-mention-ngram: Gab1 boundt%e2: args2Role-mention-ngram: bound totPe2: trigger-arg-path: bound:Binding >prep_to [lemma='grb2'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='grb2'] Gene_or_gene_productt*e2: args2Role-mention-ngram: or Gab1 boundt+e2: ents2Label-mention-ngram: Gab1 bound tot4e1: ents2Label-mention-ngram: facilitates binding oftTe1: trigger-arg-path: lemmatizedTrigger=promote dobj >prep_of controllert$e1: args2Role-mention-ngram: of botht?trigger-to-trigger-path: e1:promotes:Positive_regulation dobj [lemma='binding'] e2:binding:Bindingt:e1: ents2Label-mention-ngram: promotes the transactivationt(e1: args2Role-mention-ngram: activity oftCe1: trigger-arg-path: Positive_regulation prep_of [lemma='p300'] Gene_or_gene_producttLe1: trigger-arg-path: promotes:Positive_regulation prep_of [lemma='cbp'] themet)e1: args2Role-mention-ngram: and promotestre1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj >prep_of controller:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] controllertXe2: trigger-arg-path: binding:Binding >prep_of [lemma='p300'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binding >prep_of [lemma='cbp'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='p300'] themetXe1: trigger-arg-path: Positive_regulation >dobj >prep_of controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: CBP totoe1: trigger-arg-path: promotes >dobj [lemma='activity'] >prep_of [lemma='p300'] controller:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='cbp'] theme:Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding >prep_of [lemma='p300'] themetBshortest-path: dobj [lemma='binding']t)e1: ents2Label-mention-ngram: facilitatest\e1: trigger-arg-path: promotes:Positive_regulation dobj [lemma='activity'] >prep_of [lemma='p300'] controllert[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cbp'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=promote dobj [lemma='activity'] >prep_of [lemma='p300'] controllertDe1: trigger-arg-path: lemmatizedTrigger=promote dobj [lemma='activity'] >prep_of [lemma='p300'] controllert6e1: ents2Label-mention-ngram: transactivation activitytae1: trigger-arg-path: promotes:Positive_regulation >dobj >prep_of controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: CBP to thet(e1: ents2Label-mention-ngram: CBP to thet9e1: args2Role-mention-ngram: the transactivation activitytie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cbp'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: transactivation activity oft?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='p300'] theme:Gene_or_gene_productt-e1: args2Role-mention-ngram: and promotes thetIe2: trigger-arg-path: Binding >prep_of [lemma='cbp'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: the transactivationtre1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_of [lemma='p300'] themetme1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_of [lemma='p300'] themet[trigger-to-trigger-path: e1:promotes:Positive_regulation dobj e2:binding:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cbp'] theme:Gene_or_gene_productt#e1: args2Role-mention-ngram: CBP totGe1: trigger-arg-path: promotes:Positive_regulation dobj [lemma='activity'] >prep_of [lemma='p300'] controller:Gene_or_gene_producttOe2: trigger-arg-path: binding >prep_of [lemma='cbp'] theme:Gene_or_gene_producttXe1: trigger-arg-path: promotes dobj [lemma='activity'] >prep_of [lemma='p300'] Gene_or_gene_producttoe1: trigger-arg-path: Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] Gene_or_gene_productt8e1: trigger-arg-path: promotes >dobj >prep_of controllertVe1: trigger-arg-path: promotes:Positive_regulation >dobj >prep_of Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation prep_of [lemma='cbp'] themetIe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >prep_of controllertQe2: trigger-arg-path: binding:Binding >prep_of [lemma='cbp'] Gene_or_gene_productt&e1: args2Role-mention-ngram: C-TAD andt)e1: args2Role-mention-ngram: promotes thet&e1: args2Role-mention-ngram: the C-TADt\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='p300'] Gene_or_gene_productt?e1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] controller:Gene_or_gene_producttRe2: trigger-arg-path: binding:Binding >prep_of [lemma='p300'] Gene_or_gene_producttCe1: trigger-arg-path: promotes prep_of [lemma='cbp'] Gene_or_gene_producttxe1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] Gene_or_gene_producttne1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='activity'] >prep_of [lemma='p300'] controllert"e1: args2Role-mention-ngram: C-TADtae1: trigger-arg-path: promotes:Positive_regulation dobj >prep_of controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: botht*e1: args2Role-mention-ngram: the C-TAD andt#e1: ents2Label-mention-ngram: C-TADt?e1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activity'] >prep_of [lemma='p300'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='p300'] theme:Gene_or_gene_producttle1: trigger-arg-path: promotes:Positive_regulation prep_of [lemma='cbp'] themet9e1: ents2Label-mention-ngram: phosphorylation facilitatestAe1: ents2Label-mention-ngram: phosphorylation facilitates bindingt0e1: args2Role-mention-ngram: the transactivationt9e1: args2Role-mention-ngram: promotes the transactivationt7e1: ents2Label-mention-ngram: both GENE_OR_GENE_PRODUCTtSe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >prep_of Gene_or_gene_producttWe2: trigger-arg-path: binding:Binding >prep_of [lemma='cbp'] theme:Gene_or_gene_producttCe1: trigger-arg-path: Positive_regulation >dobj >prep_of controllertLe1: trigger-arg-path: promotes:Positive_regulation >dobj >prep_of controllertge1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj >prep_of Gene_or_gene_producttde1: trigger-arg-path: promotes >dobj [lemma='activity'] >prep_of [lemma='p300'] Gene_or_gene_producttPe2: trigger-arg-path: binding >prep_of [lemma='p300'] theme:Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation e1: trigger-arg-path: Positive_regulation prep_of [lemma='p300'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cbp'] themet8e1: trigger-arg-path: promotes dobj >prep_of Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation dobj >prep_of controller:Gene_or_gene_producttHe1: trigger-arg-path: promotes prep_of [lemma='cbp'] themet0e1: ents2Label-mention-ngram: C-TAD and promotest*e1: ents2Label-mention-ngram: promotes thet1e1: ents2Label-mention-ngram: facilitates bindingtMe1: trigger-arg-path: Positive_regulation >dobj >prep_of Gene_or_gene_productt)e2: ents2Label-mention-ngram: bind to thet/e2: ents2Label-mention-ngram: integral membranetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] theme:Generic_entitytTe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] themet!interceding-token ngrams: p40phoxt,e2: ents2Label-mention-ngram: SHARED bind tot2e2: args2Role-mention-ngram: the integral membranet6e2: trigger-arg-path: bind >nsubj [lemma='they'] themet/e2: ents2Label-mention-ngram: components FAMILYt&interceding-token ngrams: to cytosolictEe2: trigger-arg-path: bind:Binding >prep_to [lemma='gp91phox'] Familyt,e2: args2Role-mention-ngram: to the integralt1e2: ents2Label-mention-ngram: membrane componentst0e2: trigger-arg-path: bind >prep_to theme:Familyt)e2: trigger-arg-path: bind >prep_to themet%interceding-token ngrams: and p40phoxt+interceding-token ngrams: cytosolic p67phoxtWe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='gp91phox'] Familyt1e2: trigger-arg-path: bind:Binding >prep_to themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] themet>e2: trigger-arg-path: bind:Binding >nsubj [lemma='they'] themet(interceding-token ngrams: complex to thetCe2: trigger-arg-path: bind >prep_to [lemma='gp91phox'] theme:FamilytUe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='gp91phox'] theme:Familyt?e2: trigger-arg-path: Binding >prep_to [lemma='gp91phox'] themet?trigger-to-trigger-path: e1:bound:Binding >conj_and [lemma='recruit'] >prep_to [lemma='membrane'] >rcmod [lemma='bind'] e2:bind:Bindingt-interceding-token ngrams: the membranes wheretJe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:Familyt!interceding-token ngrams: p67phoxt)interceding-token ngrams: membranes wheret#interceding-token ngrams: p40phox )t*e2: args2Role-mention-ngram: THEME bind tot@e2: trigger-arg-path: Binding >prep_to [lemma='gp91phox'] Familyt$interceding-token ngrams: ) and thentMe2: trigger-arg-path: bind:Binding >nsubj [lemma='they'] theme:Generic_entityt'e2: args2Role-mention-ngram: THEME bindtYe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] Generic_entityt,interceding-token ngrams: protein complex tot]e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rac'] themet(e2: args2Role-mention-ngram: bind to thet?interceding-tokens-full-span: binds to cytosolic p67phox ( associated with p47phox and p40phox ) and then recruits the protein complex to the membranes wheret&interceding-token ngrams: with p47phoxt+interceding-token ngrams: then recruits thet'interceding-token ngrams: p40phox ) andtQe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] Generic_entityt.interceding-token ngrams: recruits the proteintDe2: trigger-arg-path: bind:Binding >prep_to [lemma='gp91phox'] themet.interceding-token ngrams: p67phox ( associatedt6e2: args2Role-mention-ngram: membrane components THEMEtre1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rac'] theme:Gene_or_gene_productt:e2: ents2Label-mention-ngram: integral membrane componentstPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] themet?e1: ents2Label-mention-ngram: SHARED bound GENE_OR_GENE_PRODUCTtFe2: trigger-arg-path: Binding >prep_to [lemma='gp91phox'] theme:Familyt&interceding-token ngrams: ( associatedt*e2: trigger-arg-path: bind >prep_to Familytie1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] theme:Gene_or_gene_productt%interceding-token ngrams: p47phox andt)e2: args2Role-mention-ngram: the integralt-e2: trigger-arg-path: Binding >prep_to Familyt%e2: ents2Label-mention-ngram: bind tot3e2: trigger-arg-path: Binding >prep_to theme:Familyt+interceding-token ngrams: ( associated witht,shortest-path: prep_to >rcmod >nsubjt'interceding-token ngrams: the membranest0e2: args2Role-mention-ngram: membrane componentst8e2: ents2Label-mention-ngram: membrane components FAMILYtprep_to [lemma='gp91phox'] themet$interceding-token ngrams: complex totKe2: trigger-arg-path: bind:Binding >prep_to [lemma='gp91phox'] theme:FamilytNe1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] themet'interceding-token ngrams: then recruitstLe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rac'] themet*interceding-token ngrams: with p47phox andt$e2: args2Role-mention-ngram: bind tot)e2: ents2Label-mention-ngram: SHARED bindt%e2: args2Role-mention-ngram: integralt'interceding-token ngrams: and p40phox )t?e2: trigger-arg-path: bind >nsubj [lemma='they'] Generic_entityt3e2: ents2Label-mention-ngram: the integral membranet-e2: args2Role-mention-ngram: components THEMEtStrigger-to-trigger-path: e1:bound:Binding >conj_and >prep_to >rcmod e2:bind:Bindingt*interceding-token ngrams: to the membranest.interceding-token ngrams: to cytosolic p67phoxtte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] Gene_or_gene_productt8e2: trigger-arg-path: bind:Binding >prep_to theme:Familyt,interceding-token ngrams: binds to cytosolict_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] theme:Generic_entitytoshortest-path: prep_to [lemma='membrane'] >rcmod [lemma='bind'] >nsubj [lemma='they']tce1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] Gene_or_gene_producttce1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] themet%interceding-token ngrams: the proteint2e2: trigger-arg-path: bind:Binding >prep_to FamilytDe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to Familytae1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rac'] theme:Gene_or_gene_producttprep_to Familyt1interceding-token ngrams: associated with p47phoxt-interceding-token ngrams: the protein complextVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='gp91phox'] themet)interceding-token ngrams: protein complext&e2: ents2Label-mention-ngram: integralt9e2: args2Role-mention-ngram: integral membrane componentst=e2: trigger-arg-path: bind >prep_to [lemma='gp91phox'] Familyt#interceding-token ngrams: cytosolict.e2: args2Role-mention-ngram: integral membranet"interceding-token ngrams: and thentinterceding-token ngrams: thentEe2: trigger-arg-path: bind >nsubj [lemma='they'] theme:Generic_entityt!interceding-token ngrams: p47phoxtze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] theme:Gene_or_gene_productt]e1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='rac'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: componentstNe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='gp91phox'] themetBe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to theme:Familyt[e1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='rac'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='rac'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='gp91phox'] Familyt'e2: args2Role-mention-ngram: componentst-interceding-token ngrams: p47phox and p40phoxt#interceding-token ngrams: p67phox (t8e1: ents2Label-mention-ngram: bound GENE_OR_GENE_PRODUCTtGe2: trigger-arg-path: bind:Binding >nsubj [lemma='they'] Generic_entityt*e2: ents2Label-mention-ngram: the integralt+interceding-token ngrams: and then recruitst]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='gp91phox'] theme:Familyt-e2: ents2Label-mention-ngram: to the integralt#interceding-token ngrams: membranest-interceding-token ngrams: cytosolic p67phox (tNe2: trigger-arg-path: bound >dobj [lemma='complex'] theme:Gene_or_gene_productt9e2: trigger-arg-path: bound >dobj [lemma='complex'] themetRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] themetVe1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] theme:Gene_or_gene_producttVe2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] theme:Gene_or_gene_producttPe2: trigger-arg-path: Binding >dobj [lemma='complex'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >dobj [lemma='complex'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] themetae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >dobj [lemma='complex'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >dobj [lemma='complex'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] themetAe1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] themet9e1: trigger-arg-path: bound >dobj [lemma='complex'] themetYe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] Gene_or_gene_producttHe2: trigger-arg-path: bound >dobj [lemma='complex'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >dobj [lemma='complex'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] theme:Gene_or_gene_producttNe1: trigger-arg-path: bound >dobj [lemma='complex'] theme:Gene_or_gene_producttPe2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] Gene_or_gene_producttAe2: trigger-arg-path: bound:Binding >dobj [lemma='complex'] themetHe1: trigger-arg-path: bound >dobj [lemma='complex'] Gene_or_gene_producttPe1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >dobj [lemma='complex'] themetne2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventtue2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent >prep_of controller:Gene_or_gene_producttZe2: trigger-arg-path: stimulated >nsubjpass [lemma='interaction'] controlled:Generic_eventt-e2: ents2Label-mention-ngram: by the presencet,e2: args2Role-mention-ngram: G12V CONTROLLERtbtrigger-to-trigger-path: e1:interaction:Generic_event agent [lemma='presence'] >prep_of [lemma='kra'] controllertje2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent >prep_of Gene_or_gene_productt*e2: args2Role-mention-ngram: stimulated byt,e2: args2Role-mention-ngram: the presence oftqe2: trigger-arg-path: stimulated >agent [lemma='presence'] >prep_of [lemma='kra'] controller:Gene_or_gene_producttEe2: trigger-arg-path: stimulated >agent >prep_of Gene_or_gene_productt*e2: ents2Label-mention-ngram: the presencet?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] controllertte2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventtMe2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass Generic_eventt,e2: args2Role-mention-ngram: by the presencet`e2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass [lemma='interaction'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] controller:Gene_or_gene_productt6e2: trigger-arg-path: stimulated >nsubjpass controlledtUe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass controlled:Generic_eventt.e2: ents2Label-mention-ngram: presence of G12VtKe1: trigger-arg-path: Binding >nsubj [lemma='rassf1a'] Gene_or_gene_productt>e1: trigger-arg-path: interacts >nsubj [lemma='rassf1a'] themet7e2: ents2Label-mention-ngram: G12V GENE_OR_GENE_PRODUCTtYe2: trigger-arg-path: stimulated:Positive_regulation >agent >prep_of Gene_or_gene_producttOe2: trigger-arg-path: stimulated:Positive_regulation >agent >prep_of controllert*e2: args2Role-mention-ngram: is stimulatedt7e2: ents2Label-mention-ngram: interaction is stimulatedt+e2: ents2Label-mention-ngram: stimulated bytFe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf1a'] themet"e2: ents2Label-mention-ngram: G12Vtme2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='presence'] >prep_of [lemma='kra'] controllert:e2: ents2Label-mention-ngram: of G12V GENE_OR_GENE_PRODUCTtVe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >prep_of Gene_or_gene_productt-e2: args2Role-mention-ngram: presence of G12Vt)e2: args2Role-mention-ngram: the presencet[e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass controlledtYe2: trigger-arg-path: Positive_regulation >agent >prep_of controller:Gene_or_gene_producttde2: trigger-arg-path: stimulated:Positive_regulation >agent >prep_of controller:Gene_or_gene_producttvtrigger-to-trigger-path: e1:interaction:Generic_event agent >prep_of controllert.e2: ents2Label-mention-ngram: is stimulated bytke2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='interaction'] controlled:Generic_eventt+e2: ents2Label-mention-ngram: is stimulatedtMe1: trigger-arg-path: interacts >nsubj [lemma='rassf1a'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >prep_of controllertce2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass [lemma='interaction'] Generic_eventtpe2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] controllert]e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='interaction'] controlledt;e2: trigger-arg-path: stimulated >agent >prep_of controllerte2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventtze2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] Gene_or_gene_producttDe2: trigger-arg-path: Positive_regulation >agent >prep_of controllert?e2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] controller:Gene_or_gene_productt9e2: trigger-arg-path: stimulated >nsubjpass Generic_eventtOe2: trigger-arg-path: stimulated >nsubjpass [lemma='interaction'] Generic_eventt)e2: ents2Label-mention-ngram: presence oft^e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='presence'] >prep_of [lemma='kra'] controller:Gene_or_gene_productt[e1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] themetnsubj [lemma='rassf1a'] themet^e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass Generic_eventtWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] themetze2: trigger-arg-path: Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] controller:Gene_or_gene_producttJe2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass controlledtNe2: trigger-arg-path: Positive_regulation >agent >prep_of Gene_or_gene_productt%e2: args2Role-mention-ngram: presencetXe2: trigger-arg-path: stimulated:Positive_regulation >nsubjpass controlled:Generic_eventtfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_productt.e2: args2Role-mention-ngram: stimulated by thetqe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass [lemma='interaction'] controlledt%e2: ents2Label-mention-ngram: of G12Vtae2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >prep_of controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='interaction'] Generic_eventtoe2: trigger-arg-path: Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: the presence oft-e2: args2Role-mention-ngram: is stimulated bytie2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubjpass controlled:Generic_eventt!e2: args2Role-mention-ngram: G12Vt\e2: trigger-arg-path: stimulated >agent [lemma='presence'] >prep_of [lemma='kra'] controllertle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass controlledt(e2: args2Role-mention-ngram: presence oftCshortest-path: auxpass [lemma='be']tDe2: trigger-arg-path: stimulated >nsubjpass controlled:Generic_eventtde1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interacts >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttfe2: trigger-arg-path: stimulated >agent [lemma='presence'] >prep_of [lemma='kra'] Gene_or_gene_productt5e2: args2Role-mention-ngram: CONTROLLED is stimulatedtPe2: trigger-arg-path: stimulated >agent >prep_of controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: of G12V CONTROLLERt&e2: ents2Label-mention-ngram: presencet/e2: ents2Label-mention-ngram: stimulated by thetLe2: trigger-arg-path: stimulated >nsubjpass [lemma='interaction'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='presence'] >prep_of [lemma='kra'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass Generic_eventt$e2: args2Role-mention-ngram: of G12VtUe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='presence'] >prep_of [lemma='kra'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj Generic_eventtCe2: trigger-arg-path: block:Negative_regulation >dobj Generic_eventtTe2: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] controlledtze2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Generic_eventt-e2: args2Role-mention-ngram: CONTROLLER blockt]e2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj Gene_or_gene_productt"interceding-token ngrams: order tot interceding-token ngrams: inducet%interceding-token ngrams: autophagy ,t$interceding-token ngrams: Beclin1 int]e2: trigger-arg-path: block:Negative_regulation >dobj [lemma='phosphorylation'] Generic_eventtKe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated phosphorylationt@e2: trigger-arg-path: block >nsubj [lemma='oligomer'] controllert=e2: trigger-arg-path: Negative_regulation >dobj Generic_eventtbe2: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] controlled:Generic_eventtie2: trigger-arg-path: block:Negative_regulation >nsubj [lemma='oligomer'] controller:Gene_or_gene_productt'interceding-token ngrams: and thereforetRe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj controlledt%interceding-token ngrams: in order totce2: trigger-arg-path: Negative_regulation >nsubj [lemma='oligomer'] controller:Gene_or_gene_producttFe2: trigger-arg-path: block >dobj [lemma='phosphorylation'] controlledt-interceding-token ngrams: to induce autophagyt)interceding-token ngrams: therefore freest-e2: trigger-arg-path: block >nsubj controllert'interceding-token ngrams: frees Beclin1t/e2: trigger-arg-path: block >dobj Generic_eventt"interceding-token ngrams: in ordert*interceding-token ngrams: induce autophagyt@e2: trigger-arg-path: block:Negative_regulation >dobj controlledt,e2: trigger-arg-path: block >dobj controlledtVe2: trigger-arg-path: block:Negative_regulation >nsubj controller:Gene_or_gene_productt*interceding-token ngrams: frees Beclin1 int:e2: trigger-arg-path: block >dobj controlled:Generic_eventtge2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='oligomer'] controller:Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT block thistWe2: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] Generic_eventt2e2: args2Role-mention-ngram: block this CONTROLLEDt)interceding-token ngrams: order to inducet?e1: ents2Label-mention-ngram: triggers the GENE_OR_GENE_PRODUCTtltrigger-to-trigger-path: e1:triggers:Positive_regulation >advcl [lemma='block'] e2:block:Negative_regulationtTe2: trigger-arg-path: block >dobj [lemma='phosphorylation'] controlled:Generic_eventtNe2: trigger-arg-path: Negative_regulation >nsubj [lemma='oligomer'] controllert(e2: ents2Label-mention-ngram: block thist'e1: ents2Label-mention-ngram: of FAMILYtIe2: trigger-arg-path: lemmatizedTrigger=block >nsubj Gene_or_gene_producttKe2: trigger-arg-path: block:Negative_regulation >nsubj Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='oligomer'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT blocktle2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj [lemma='phosphorylation'] controlledt>e2: trigger-arg-path: lemmatizedTrigger=block >dobj controlledtTe2: trigger-arg-path: lemmatizedTrigger=block >nsubj controller:Gene_or_gene_productt-interceding-token ngrams: and therefore freest\trigger-to-trigger-path: e1:triggers:Positive_regulation >advcl e2:block:Negative_regulationt'e2: args2Role-mention-ngram: block thist,interceding-token ngrams: induce autophagy ,t?e2: trigger-arg-path: lemmatizedTrigger=block >nsubj controllert7e1: ents2Label-mention-ngram: phosphorylation of FAMILYt7e2: trigger-arg-path: block >nsubj Gene_or_gene_productt^e2: trigger-arg-path: block:Negative_regulation >nsubj [lemma='oligomer'] Gene_or_gene_producttTe2: trigger-arg-path: block:Negative_regulation >nsubj [lemma='oligomer'] controllert^interceding-tokens-full-span: and therefore frees Beclin1 in order to induce autophagy , whilet[e2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='phosphorylation'] Generic_eventt1interceding-token ngrams: therefore frees Beclin1tinterceding-token ngrams: ordertHe2: trigger-arg-path: Negative_regulation >dobj controlled:Generic_eventtsshortest-path: advcl [lemma='block'] >nsubj [lemma='oligomer'] >nn [lemma='amyloid-beta']tAe2: trigger-arg-path: lemmatizedTrigger=block >dobj Generic_eventtRe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='oligomer'] controllertinterceding-token ngrams: freestAe2: trigger-arg-path: block:Negative_regulation >nsubj controllertSe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj controllert{e2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='oligomer'] controller:Gene_or_gene_productt#interceding-token ngrams: thereforet\e2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='oligomer'] Gene_or_gene_productthe2: trigger-arg-path: block:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Generic_eventtXe2: trigger-arg-path: Negative_regulation >nsubj [lemma='oligomer'] Gene_or_gene_producttJe2: trigger-arg-path: block >nsubj [lemma='oligomer'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj controlled:Generic_eventtIe2: trigger-arg-path: block >dobj [lemma='phosphorylation'] Generic_eventtfe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='oligomer'] controllert2e2: ents2Label-mention-ngram: this phosphorylationt#interceding-token ngrams: to inducetfe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='phosphorylation'] controlled:Generic_eventtoe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >dobj [lemma='phosphorylation'] Generic_eventtXe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='phosphorylation'] controlledtBe2: trigger-arg-path: block >nsubj controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER block thisthe2: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj controller:Gene_or_gene_productt*interceding-token ngrams: Beclin1 in ordertZe2: trigger-arg-path: block:Negative_regulation >dobj [lemma='phosphorylation'] controlledt?e1: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCT mediatedtNe2: trigger-arg-path: block:Negative_regulation >dobj controlled:Generic_eventt+interceding-token ngrams: autophagy , whilet8e2: ents2Label-mention-ngram: block this phosphorylationtUe2: trigger-arg-path: block >nsubj [lemma='oligomer'] controller:Gene_or_gene_productt!interceding-token ngrams: Beclin1tLe2: trigger-arg-path: lemmatizedTrigger=block >dobj controlled:Generic_eventtIe1: trigger-arg-path: diminishes >nsubj >prep_of >nn Gene_or_gene_producttBe2: trigger-arg-path: bound:Binding >nsubj >prep_to >prep_of themet,e1: ents2Label-mention-ngram: diminishes thet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt#interceding-token ngrams: prolongedt3e1: args2Role-mention-ngram: CONTROLLER activity intKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_to >prep_of themet#interceding-token ngrams: , leadingt?shortest-path: nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp']t/e1: ents2Label-mention-ngram: the cells abilityt%e1: ents2Label-mention-ngram: abilityt?e2: trigger-arg-path: bound >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controllertTe1: trigger-arg-path: diminishes >nsubj >prep_of >nn controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: diminishest?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] themet3e1: args2Role-mention-ngram: amplify the CONTROLLEDt%e1: ents2Label-mention-ngram: amplifyt?e1: trigger-arg-path: diminishes >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlled:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubj >prep_to >prep_of Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=diminish >nsubj >prep_of >nn Gene_or_gene_producttxcomp >dobj >nn controlledtFe1: trigger-arg-path: diminishes >xcomp >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activityt?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] Gene_or_gene_productt0interceding-token ngrams: accumulation of activet?e1: trigger-arg-path: diminishes >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: diminishestce1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj >prep_of >nn controllert]e1: trigger-arg-path: Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER activityt|e1: trigger-arg-path: diminishes >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp >dobj >nn controlled:Gene_or_gene_producttPe1: trigger-arg-path: diminishes:Positive_activation >xcomp >dobj >nn controlledt-e1: args2Role-mention-ngram: cells ability tot}e2: trigger-arg-path: bound >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] Gene_or_gene_productt/e1: args2Role-mention-ngram: ability to amplifyt?e1: trigger-arg-path: diminishes >nsubj >prep_of >nn controllertOe2: trigger-arg-path: bound >nsubj >prep_to >prep_of theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_to >prep_of themet4interceding-token ngrams: the prolonged accumulationt/e1: ents2Label-mention-ngram: in PCa diminishest?e1: trigger-arg-path: diminishes:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlled:Gene_or_gene_productt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activity int)e1: ents2Label-mention-ngram: activity int:e2: trigger-arg-path: bound >nsubj >prep_to >prep_of themet?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controller:Gene_or_gene_productt?e1: trigger-arg-path: diminishes:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] Gene_or_gene_productt+e1: args2Role-mention-ngram: PCa diminishestae1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp >dobj >nn controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: ability tot?e1: trigger-arg-path: diminishes:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: to amplify thetne2: trigger-arg-path: bound >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] themet'e1: ents2Label-mention-ngram: the cellst)interceding-token ngrams: accumulation oft)e1: ents2Label-mention-ngram: amplify thete2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] themet?e1: trigger-arg-path: diminishes >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Positive_activation >xcomp >dobj >nn Gene_or_gene_producttHe1: trigger-arg-path: Positive_activation >nsubj >prep_of >nn controllert&interceding-token ngrams: , leading tot&interceding-token ngrams: accumulationtnsubj >prep_to >prep_of themet,e1: args2Role-mention-ngram: activity in PCat?e1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] Gene_or_gene_producttve2: trigger-arg-path: bound:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] themetRtrigger-to-trigger-path: e1:diminishes:Positive_activation nsubj >prep_to >prep_of Gene_or_gene_producttinterceding-token ngrams: Ras ,t#interceding-token ngrams: of activetee1: trigger-arg-path: diminishes:Positive_activation >xcomp >dobj >nn controlled:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_to >prep_of Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_to >prep_of theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: ability totZe1: trigger-arg-path: Positive_activation >xcomp >dobj >nn controlled:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp >dobj >nn Gene_or_gene_producttBshortest-path: nsubj >prep_to >prep_oft0e1: ents2Label-mention-ngram: ability to amplifyt?e2: trigger-arg-path: bound:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] Gene_or_gene_productt+e1: args2Role-mention-ngram: diminishes thet'interceding-token ngrams: Ras , leadingt`e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp >dobj >nn controlledt2e1: ents2Label-mention-ngram: diminishes the cellst$e1: ents2Label-mention-ngram: in PCat+e1: ents2Label-mention-ngram: cells abilityt'interceding-token ngrams: the prolongedtQe2: trigger-arg-path: Binding >nsubj >prep_to >prep_of theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: bound FAMILYt?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=diminish >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controllerte2: trigger-arg-path: Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp >dobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlledt!e1: ents2Label-mention-ngram: PCat(e1: args2Role-mention-ngram: amplify thet{e1: trigger-arg-path: Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlledt(e1: args2Role-mention-ngram: activity int0interceding-token ngrams: prolonged accumulationt?e1: trigger-arg-path: diminishes:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controller:Gene_or_gene_producttre1: trigger-arg-path: diminishes >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlledt]e1: trigger-arg-path: diminishes:Positive_activation >nsubj >prep_of >nn Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: to amplifyte1: trigger: diminishest?e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_to >prep_of theme:Gene_or_gene_producttQe1: trigger-arg-path: diminishes >xcomp >dobj >nn controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: to amplifyt-e1: ents2Label-mention-ngram: activity in PCat.e1: args2Role-mention-ngram: the cells abilitytye1: trigger-arg-path: diminishes >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controllert*interceding-token ngrams: to the prolongedtatrigger-to-trigger-path: e1:diminishes:Positive_activation nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: in PCatIe2: trigger-arg-path: bound >nsubj >prep_to >prep_of Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] Gene_or_gene_producttEe1: trigger-arg-path: Positive_activation >xcomp >dobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] Gene_or_gene_productt?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound FAMILYt?e1: trigger-arg-path: diminishes:Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controllert)interceding-token ngrams: activity of Rast.e1: args2Role-mention-ngram: in PCa diminishest_interceding-tokens-full-span: activity of Ras , leading to the prolonged accumulation of activethe1: trigger-arg-path: diminishes:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt>e1: ents2Label-mention-ngram: amplify the GENE_OR_GENE_PRODUCTtQe2: trigger-arg-path: bound:Binding >nsubj >prep_to >prep_of Gene_or_gene_producttZe1: trigger-arg-path: diminishes:Positive_activation >xcomp >dobj >nn Gene_or_gene_producttSe1: trigger-arg-path: diminishes:Positive_activation >nsubj >prep_of >nn controllert0e1: ents2Label-mention-ngram: PCa diminishes thet?e1: trigger-arg-path: Positive_activation >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] controllert/e1: args2Role-mention-ngram: PCa diminishes thet1e1: args2Role-mention-ngram: diminishes the cellstWe2: trigger-arg-path: bound:Binding >nsubj >prep_to >prep_of theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt3interceding-token ngrams: prolonged accumulation oft,e1: ents2Label-mention-ngram: PCa diminishestRe1: trigger-arg-path: Positive_activation >nsubj >prep_of >nn Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=diminish >nsubj >prep_of >nn controllertme1: trigger-arg-path: lemmatizedTrigger=diminish:Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt e1: args2Role-mention-ngram: PCat*e1: args2Role-mention-ngram: cells abilityt+e1: args2Role-mention-ngram: to amplify thetVe1: trigger-arg-path: lemmatizedTrigger=diminish >xcomp >dobj >nn Gene_or_gene_productt$e1: args2Role-mention-ngram: amplifyt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] Gene_or_gene_productt"interceding-token ngrams: of Ras ,t?e1: trigger-arg-path: diminishes:Positive_activation >xcomp [lemma='amplify'] >dobj [lemma='activity'] >nn [lemma='gtpase'] controlledt$e1: args2Role-mention-ngram: abilityt&e1: args2Role-mention-ngram: the cellstde1: trigger-arg-path: lemmatizedTrigger=diminish >nsubj >prep_of >nn controller:Gene_or_gene_producttpe2: trigger-arg-path: Binding >nsubj [lemma='lead'] >prep_to [lemma='accumulation'] >prep_of [lemma='gtp'] themet.e1: ents2Label-mention-ngram: cells ability tot?e1: trigger-arg-path: lemmatizedTrigger=diminish >nsubj [lemma='attenuation'] >prep_of [lemma='activity'] >nn [lemma='dab2ip'] Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='rac'] Gene_or_gene_productt/e2: args2Role-mention-ngram: to cytosolic THEMEt?e2: ents2Label-mention-ngram: to cytosolic GENE_OR_GENE_PRODUCTtGe2: trigger-arg-path: Binding >nsubj [lemma='rac'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: to cytosolict>e2: trigger-arg-path: Binding >prep_to [lemma='p67phox'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p67phox'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: binds to cytosolictSe2: trigger-arg-path: Binding >prep_to [lemma='p67phox'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] themet>e2: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rac'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p67phox'] Gene_or_gene_productt/e2: args2Role-mention-ngram: binds to cytosolictOshortest-path: ccomp [lemma='bind'] >nsubj [lemma='rac']t\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='rac'] themetMe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p67phox'] themet)e2: args2Role-mention-ngram: to cytosolictprep_to [lemma='p67phox'] themetje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p67phox'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p67phox'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] themetVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rac'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p67phox'] themetMe2: trigger-arg-path: Binding >prep_to [lemma='p67phox'] Gene_or_gene_productt&e2: args2Role-mention-ngram: cytosolictDe2: trigger-arg-path: binds:Binding >prep_to [lemma='p67phox'] themetMe2: trigger-arg-path: Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: cytosolictnsubj [lemma='rac'] themetQe2: trigger-arg-path: binds >prep_to [lemma='p67phox'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >prep_to [lemma='p67phox'] Gene_or_gene_producttYe2: trigger-arg-path: binds:Binding >prep_to [lemma='p67phox'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] Gene_or_gene_producttKe2: trigger-arg-path: binds >prep_to [lemma='p67phox'] Gene_or_gene_productt,e2: args2Role-mention-ngram: cytosolic THEMEtSe2: trigger-arg-path: binds:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_producttKe2: trigger-arg-path: binds >nsubj [lemma='rac'] theme:Gene_or_gene_producttprep_with [lemma='spry2'] Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with Gene_or_gene_productt-e2: args2Role-mention-ngram: Ser121 for THEMEt\e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='spry2'] themetfe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='nedd4'] controller:Gene_or_gene_producttJe1: trigger-arg-path: requires >nsubj [lemma='nedd4'] Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER requires Mnk2tie2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='spry2'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Positive_regulation >nsubj [lemma='nedd4'] controllertxe2: trigger-arg-path: Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] sitet(e2: ents2Label-mention-ngram: Ser121 fortQe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='nedd4'] controllertVe2: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_of site:Sitet4e1: ents2Label-mention-ngram: for SHARED interactiont!e1: args2Role-mention-ngram: Mnk2t?e2: trigger-arg-path: lemmatizedTrigger=interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] site:Sitet@e2: trigger-arg-path: Binding dobj >prep_of site:Sitetze1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='nedd4'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: for THEMEt[e1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='nedd4'] Gene_or_gene_productt?e2: trigger-arg-path: interaction dobj >prep_of sitet$e1: ents2Label-mention-ngram: Ser112t0e1: args2Role-mention-ngram: CONTROLLER requirest>e2: trigger-arg-path: Binding >prep_with [lemma='spry2'] themetUe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj controllert(e1: ents2Label-mention-ngram: Ser112 andt*e1: args2Role-mention-ngram: requires Mnk2tQe2: trigger-arg-path: interaction >prep_with [lemma='spry2'] Gene_or_gene_productt6e1: args2Role-mention-ngram: phosphorylation of Ser112tYe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_of Sitet5e1: ents2Label-mention-ngram: requires Mnk2 dependenttUe1: trigger-arg-path: requires >nsubj [lemma='nedd4'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: and Ser121t`e1: trigger-arg-path: Positive_regulation >nsubj [lemma='nedd4'] controller:Gene_or_gene_productt|e2: trigger-arg-path: interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] sitetAe2: trigger-arg-path: interaction >prep_with Gene_or_gene_productt$e1: ents2Label-mention-ngram: Ser121t'e2: args2Role-mention-ngram: and Ser121tQe2: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_of Sitet%e2: args2Role-mention-ngram: SITE andte2: SITE: 3tTe1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='nedd4'] controllertJe2: trigger-arg-path: interaction:Binding >prep_with [lemma='spry2'] themet$e2: ents2Label-mention-ngram: Ser121t6e1: args2Role-mention-ngram: dependent phosphorylationt}e2: trigger-arg-path: Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] site:Sitet'e1: args2Role-mention-ngram: Ser112 andtLe2: trigger-arg-path: interaction:Binding dobj >prep_of site:Sitet+e1: args2Role-mention-ngram: Mnk2 dependentt(e1: ents2Label-mention-ngram: Ser121 fortje1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=require >nsubj Gene_or_gene_producttie1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='nedd4'] controller:Gene_or_gene_productt?e2: trigger-arg-path: interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] site:Sitetxe2: trigger-arg-path: Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] Sitet$e2: ents2Label-mention-ngram: Ser112t[e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with Gene_or_gene_productt#e1: args2Role-mention-ngram: Ser112t;e2: trigger-arg-path: Binding dobj >prep_of sitet?e2: trigger-arg-path: interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] sitet0e1: trigger-arg-path: requires >nsubj controllertGe2: trigger-arg-path: interaction >prep_with theme:Gene_or_gene_producttUe1: trigger-arg-path: Positive_regulation >nsubj [lemma='nedd4'] Gene_or_gene_producttashortest-path: dobj [lemma='phosphorylation'] >prep_of [lemma='ser112']tIe2: trigger-arg-path: interaction:Binding >prep_with Gene_or_gene_productt@e1: trigger-arg-path: requires >nsubj [lemma='nedd4'] controllertotrigger-to-trigger-path: e1:requires:Positive_regulation >prep_for [lemma='interaction'] e2:interaction:Bindingt"e1: ents2Label-mention-ngram: Mnk2t4e1: args2Role-mention-ngram: requires Mnk2 dependentt,e1: ents2Label-mention-ngram: and Ser121 fort,e2: args2Role-mention-ngram: SITE and Ser121t?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] sitet&e1: args2Role-mention-ngram: of Ser112tYe2: trigger-arg-path: interaction:Binding >prep_with [lemma='spry2'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: Ser112 and Ser121t+e1: ents2Label-mention-ngram: of Ser112 andt/e1: ents2Label-mention-ngram: Ser121 for SHAREDt#e2: args2Role-mention-ngram: Ser121t?e2: trigger-arg-path: interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] site:SitetTe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='spry2'] themet^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_of site:SitetEe1: trigger-arg-path: requires >nsubj controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: fort(e2: ents2Label-mention-ngram: for SHAREDt;e1: args2Role-mention-ngram: Mnk2 dependent phosphorylationt?e2: trigger-arg-path: interaction dobj >prep_of Sitet|e2: trigger-arg-path: interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] Sitet'e1: ents2Label-mention-ngram: of Ser112t2e1: args2Role-mention-ngram: Ser112 and CONTROLLEDt?e2: trigger-arg-path: interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] Sitet(e1: ents2Label-mention-ngram: and Ser121t9e1: args2Role-mention-ngram: dependent phosphorylation oft?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] SitetWe2: trigger-arg-path: interaction >prep_with [lemma='spry2'] theme:Gene_or_gene_producttDe2: trigger-arg-path: interaction dobj >prep_of site:SitetGe2: trigger-arg-path: interaction:Binding dobj >prep_of sitet e2: args2Role-mention-ngram: fortYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: Mnk2 dependentt7e1: ents2Label-mention-ngram: phosphorylation of Ser112tSe2: trigger-arg-path: Binding >prep_with [lemma='spry2'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: for SHARED interactiontDe1: trigger-arg-path: requires:Positive_regulation >nsubj controllert^e1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='nedd4'] Gene_or_gene_productt+e2: args2Role-mention-ngram: and Ser121 fort;e2: trigger-arg-path: Binding dobj >prep_of Sitet(e1: ents2Label-mention-ngram: for SHAREDt$shortest-path: dobj >prep_oftae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with theme:Gene_or_gene_producttYtrigger-to-trigger-path: e1:requires:Positive_regulation >prep_for e2:interaction:Bindingt,e2: ents2Label-mention-ngram: and Ser121 fortNe1: trigger-arg-path: requires:Positive_regulation >nsubj Gene_or_gene_productt*e1: args2Role-mention-ngram: of Ser112 andt?e2: trigger-arg-path: lemmatizedTrigger=interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] sitetOe2: trigger-arg-path: interaction:Binding >prep_with theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj Gene_or_gene_producttYe1: trigger-arg-path: requires:Positive_regulation >nsubj controller:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='spry2'] theme:Gene_or_gene_producttGe2: trigger-arg-path: interaction:Binding dobj >prep_of SitetBe2: trigger-arg-path: interaction >prep_with [lemma='spry2'] themetoe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='nedd4'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_of sitetAe1: trigger-arg-path: lemmatizedTrigger=require >nsubj controllert2e2: args2Role-mention-ngram: for THEME interactiontVe1: trigger-arg-path: lemmatizedTrigger=require >nsubj controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: Ser121 for SHAREDtee1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='nedd4'] controllertke2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='spry2'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: Ser112 andt:e1: trigger-arg-path: requires >nsubj Gene_or_gene_productt+e1: ents2Label-mention-ngram: requires Mnk2t/e1: ents2Label-mention-ngram: Ser112 and Ser121tYe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_of sitet?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] site:Sitet2e1: ents2Label-mention-ngram: SHARED requires Mnk2t'e2: args2Role-mention-ngram: Ser121 fort_e2: trigger-arg-path: interaction:Binding >prep_with [lemma='spry2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interaction dobj [lemma='phosphorylation'] >prep_of [lemma='ser112'] SitetMe2: trigger-arg-path: Binding >prep_with [lemma='spry2'] Gene_or_gene_productte2: trigger: reversedte2: args2Role-mention-ngram: bet`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pi3k'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: ( PIP2 )t&e2: ents2Label-mention-ngram: ( PIP2 )t'e2: ents2Label-mention-ngram: which cant'e1: ents2Label-mention-ngram: PIP2 ) tot&e2: args2Role-mention-ngram: which cant9e2: trigger-arg-path: reversed >agent >prep_of >nn Familyt&e2: ents2Label-mention-ngram: reversedt3e1: ents2Label-mention-ngram: SHARED phosphorylatest/e2: ents2Label-mention-ngram: process which cant9e1: ents2Label-mention-ngram: phosphatidylinositol-4 ,5 -t?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controller:FamilytZe1: trigger-arg-path: phosphorylates >nsubj [lemma='pi3k'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: by the actiont3e2: ents2Label-mention-ngram: SHARED phosphorylateste2: ents2Label-mention-ngram: -t,e2: ents2Label-mention-ngram: - bisphosphatet?e2: trigger-arg-path: reversed:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controllert$e2: ents2Label-mention-ngram: ( PIP2t-e2: ents2Label-mention-ngram: reversed by thet1e2: ents2Label-mention-ngram: bisphosphate ( PIP2t?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj [lemma='pi3k'] controlledtktrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj >rcmod e2:reversed:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=reverse >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] FamilytTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_producttte2: trigger-arg-path: reversed >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=reverse >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controllertJe2: ents2Label-mention-ngram: SHARED phosphorylates phosphatidylinositol-4t?e2: trigger-arg-path: reversed:Negative_regulation nsubj [lemma='pi3k'] controlled:Positive_regulationt$e2: ents2Label-mention-ngram: can betOe1: trigger-arg-path: phosphorylates >nsubj [lemma='pi3k'] Gene_or_gene_productt?e2: trigger-arg-path: reversed:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] Familyt.e2: ents2Label-mention-ngram: - bisphosphate (tXe2: trigger-arg-path: reversed:Negative_regulation >agent >prep_of >nn controller:FamilytJe2: trigger-arg-path: lemmatizedTrigger=reverse >agent >prep_of >nn Familyt'e2: ents2Label-mention-ngram: of FAMILYt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controllert?e2: trigger-arg-path: Negative_regulation nsubj [lemma='pi3k'] Positive_regulationtie2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent >prep_of >nn controller:Familyt"e2: ents2Label-mention-ngram: PIP3t$e2: ents2Label-mention-ngram: PIP3 )tEe1: trigger-arg-path: phosphorylates >nsubj [lemma='pi3k'] controllertbe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj controlled:Positive_regulationt.e2: args2Role-mention-ngram: CONTROLLED ( PIP3tJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] controllert+e2: args2Role-mention-ngram: be reversed byt,e2: args2Role-mention-ngram: reversed by thet?e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='pi3k'] Positive_regulationtQe2: trigger-arg-path: Negative_regulation nsubj Positive_regulationtCe1: ents2Label-mention-ngram: phosphorylates phosphatidylinositol-4t,e2: ents2Label-mention-ngram: be reversed byt9e2: ents2Label-mention-ngram: phosphatidylinositol-4 ,5 -t?e2: trigger-arg-path: Negative_regulation nsubj [lemma='pi3k'] controlledt?e2: trigger-arg-path: reversed nsubj [lemma='pi3k'] controlled:Positive_regulationtDe2: trigger-arg-path: reversed >agent >prep_of >nn controller:FamilytQe2: trigger-arg-path: reversed nsubj controlled:Positive_regulationt-shortest-path: nsubj [lemma='pi3k'] controlled:Positive_regulationt$e1: ents2Label-mention-ngram: PIP2 )t#e2: args2Role-mention-ngram: can bet/e1: ents2Label-mention-ngram: ,5 - bisphosphatetJe1: ents2Label-mention-ngram: SHARED phosphorylates phosphatidylinositol-4t*e2: args2Role-mention-ngram: process whicht"e2: args2Role-mention-ngram: ) , at=e2: trigger-arg-path: reversed nsubj controlledt"e1: ents2Label-mention-ngram: ) tot'e2: args2Role-mention-ngram: the actiont1e2: args2Role-mention-ngram: action of CONTROLLERt"e1: ents2Label-mention-ngram: PIP2tbe2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj controlledtxe2: trigger-arg-path: reversed >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controllert%e2: args2Role-mention-ngram: ( PIP3 )t*e1: ents2Label-mention-ngram: bisphosphatet?e2: trigger-arg-path: Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controllert7e2: ents2Label-mention-ngram: phosphatidylinositol-4 ,5t'e2: ents2Label-mention-ngram: action oft#e2: ents2Label-mention-ngram: ) , at?e2: trigger-arg-path: reversed:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controller:Familyt&e2: args2Role-mention-ngram: action oft#e2: args2Role-mention-ngram: PIP3 )t4e2: ents2Label-mention-ngram: phosphatidylinositol-4t e1: ents2Label-mention-ngram: ,5t(e2: ents2Label-mention-ngram: the actiont-e2: ents2Label-mention-ngram: a process whicht)e2: ents2Label-mention-ngram: ) to SHAREDt*e2: ents2Label-mention-ngram: bisphosphatetQe2: trigger-arg-path: reversed:Negative_regulation nsubj controlledt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj [lemma='pi3k'] Positive_regulationt?e2: trigger-arg-path: reversed:Negative_regulation nsubj [lemma='pi3k'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] Familyt$e2: ents2Label-mention-ngram: actiont+e2: ents2Label-mention-ngram: process whicht"e2: ents2Label-mention-ngram: ) tot.e2: ents2Label-mention-ngram: action of FAMILYtCe2: ents2Label-mention-ngram: phosphorylates phosphatidylinositol-4t"e2: ents2Label-mention-ngram: PIP2t$e2: ents2Label-mention-ngram: PIP2 )t\e2: trigger-arg-path: Negative_regulation nsubj controlled:Positive_regulationtFe1: ents2Label-mention-ngram: phosphorylates phosphatidylinositol-4 ,5t&e2: ents2Label-mention-ngram: ( PIP3 )tZe2: trigger-arg-path: reversed:Negative_regulation nsubj Positive_regulationt.e1: ents2Label-mention-ngram: - bisphosphate (tNe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj controlledt?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj [lemma='phosphatidylinositol-4'] >rcmod [lemma='reverse'] e2:reversed:Negative_regulationt*e2: ents2Label-mention-ngram: which can betHe2: trigger-arg-path: Negative_regulation nsubj controlledt=e2: trigger-arg-path: reversed >agent >prep_of >nn controllert,e1: ents2Label-mention-ngram: bisphosphate (t1e1: ents2Label-mention-ngram: bisphosphate ( PIP2t?e2: trigger-arg-path: reversed:Negative_regulation nsubj [lemma='pi3k'] Positive_regulationt"e1: ents2Label-mention-ngram: ,5 -tWe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj Positive_regulationt*e2: args2Role-mention-ngram: the action oft?e2: trigger-arg-path: reversed nsubj [lemma='pi3k'] Positive_regulationtVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pi3k'] controllert e2: ents2Label-mention-ngram: ,5tce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_producttee2: trigger-arg-path: reversed:Negative_regulation nsubj controlled:Positive_regulationt$e2: ents2Label-mention-ngram: ( PIP3t?e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='pi3k'] controlledtte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent >prep_of >nn controllert)e2: ents2Label-mention-ngram: to SHARED (tDe2: trigger-arg-path: Negative_regulation >agent >prep_of >nn Familyt7e1: ents2Label-mention-ngram: phosphatidylinositol-4 ,5t'e2: ents2Label-mention-ngram: PIP2 ) tot)e2: ents2Label-mention-ngram: reversed byt?e2: trigger-arg-path: Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj [lemma='pi3k'] controlled:Positive_regulationt%e2: args2Role-mention-ngram: PIP3 ) ,te1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_producttHe2: trigger-arg-path: Negative_regulation >agent >prep_of >nn controllert(e2: args2Role-mention-ngram: reversed byt?e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='pi3k'] controlled:Positive_regulationt,e2: ents2Label-mention-ngram: bisphosphate (te2: outgoing: >dept!e2: args2Role-mention-ngram: PIP3t)e2: ents2Label-mention-ngram: be reversedt%e2: args2Role-mention-ngram: reversedt$e1: ents2Label-mention-ngram: ( PIP2tQe2: trigger-arg-path: reversed:Negative_regulation >agent >prep_of >nn controllert)e1: ents2Label-mention-ngram: ) to SHAREDt-e2: ents2Label-mention-ngram: can be reversedt#e2: args2Role-mention-ngram: actiont,e2: args2Role-mention-ngram: a process whichtke2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj Positive_regulationt*e2: args2Role-mention-ngram: by the actiont"e2: ents2Label-mention-ngram: ,5 -te2: trigger-arg-path: reversed >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controller:Familyt?e2: trigger-arg-path: reversed nsubj [lemma='pi3k'] controlledtYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pi3k'] controllertUe2: trigger-arg-path: lemmatizedTrigger=reverse >agent >prep_of >nn controller:Familytke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pi3k'] controller:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation nsubj controlled:Positive_regulationt(e2: args2Role-mention-ngram: be reversedt?e2: trigger-arg-path: lemmatizedTrigger=reverse >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] controller:Familyte2: trigger-arg-path: Negative_regulation >agent [lemma='action'] >prep_of [lemma='homologue'] >nn [lemma='phosphatase'] Familyt+e2: ents2Label-mention-ngram: the action oft.e2: args2Role-mention-ngram: process which cantje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pi3k'] controllert e2: ents2Label-mention-ngram: betNe2: trigger-arg-path: lemmatizedTrigger=reverse >agent >prep_of >nn controllert/e2: ents2Label-mention-ngram: ,5 - bisphosphatete1: outgoing: >deptne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_producttMe2: trigger-arg-path: reversed:Negative_regulation >agent >prep_of >nn FamilytFe2: trigger-arg-path: reversed nsubj Positive_regulationt&e2: ents2Label-mention-ngram: PIP3 ) ,t,e1: ents2Label-mention-ngram: - bisphosphatet)e2: args2Role-mention-ngram: which can bet+e2: ents2Label-mention-ngram: SHARED ( PIP3t^e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >agent >prep_of >nn FamilytFe2: ents2Label-mention-ngram: phosphorylates phosphatidylinositol-4 ,5te1: ents2Label-mention-ngram: -t4e1: ents2Label-mention-ngram: phosphatidylinositol-4t,e2: args2Role-mention-ngram: can be reversedtOe2: trigger-arg-path: Negative_regulation >agent >prep_of >nn controller:Familyt#e2: args2Role-mention-ngram: ( PIP3t*e2: ents2Label-mention-ngram: Ser473 whicht;e1: trigger-arg-path: modulates >nsubj Gene_or_gene_producttstrigger-to-trigger-path: e1:modulates:Positive_regulation >prepc_by >prep_on >rcmod e2:enhances:Positive_regulationt[e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj controllert'e2: ents2Label-mention-ngram: on Thr308t$e2: ents2Label-mention-ngram: Thr308t'e1: ents2Label-mention-ngram: to growthtxe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj Positive_regulationt/e2: ents2Label-mention-ngram: to growth factorst2e1: ents2Label-mention-ngram: survival in responsetVe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtorc2'] Gene_or_gene_productt?e2: trigger-arg-path: enhances nsubj [lemma='mtorc2'] controller:Positive_regulationt0e1: ents2Label-mention-ngram: response to growtht4e1: args2Role-mention-ngram: modulates cell survivalt2e2: args2Role-mention-ngram: subsequent CONTROLLEDt0e1: ents2Label-mention-ngram: phosphorylation ont7e1: ents2Label-mention-ngram: phosphorylating SHARED ont1e1: trigger-arg-path: modulates >nsubj controllertke1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_regulation >nsubj controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: survival int e2: ents2Label-mention-ngram: ont?e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='mtorc2'] controller:Positive_regulationt,e2: ents2Label-mention-ngram: which enhancest+e2: args2Role-mention-ngram: which enhancest.e1: args2Role-mention-ngram: to growth factorst`e1: trigger-arg-path: modulates:Positive_regulation >nsubj [lemma='mtorc2'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: modulates celltOe1: trigger-arg-path: modulates:Positive_regulation >nsubj Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED modulatest!e1: args2Role-mention-ngram: cellt%e1: args2Role-mention-ngram: survivalt.e1: ents2Label-mention-ngram: SHARED on Ser473tSe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='mtorc2'] controllert8e1: ents2Label-mention-ngram: factors by phosphorylatingt?e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='mtorc2'] controllert&e1: ents2Label-mention-ngram: survivalt^e2: trigger-arg-path: enhances nsubj controller:Positive_regulationt1e1: ents2Label-mention-ngram: Akt phosphorylationt0e2: args2Role-mention-ngram: enhances subsequentt'e1: ents2Label-mention-ngram: on Ser473t&e2: ents2Label-mention-ngram: survivalt1e1: args2Role-mention-ngram: survival in responset-e1: ents2Label-mention-ngram: on Ser473 whichtWe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj controller:Gene_or_gene_producttVe1: trigger-arg-path: modulates:Positive_regulation >nsubj [lemma='mtorc2'] controllertge1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_regulation >nsubj [lemma='mtorc2'] controllert/e1: ents2Label-mention-ngram: growth factors byt^e2: trigger-arg-path: enhances:Positive_regulation nsubj controllert%e2: ents2Label-mention-ngram: factorst1e1: args2Role-mention-ngram: CONTROLLER modulatest?e2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='mtorc2'] Positive_regulationt+e2: ents2Label-mention-ngram: cell survivalt8e2: ents2Label-mention-ngram: enhances subsequent SHAREDt&e1: ents2Label-mention-ngram: enhancest?e2: ents2Label-mention-ngram: subsequent SHARED phosphorylationt0e2: ents2Label-mention-ngram: phosphorylation ont?e2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='mtorc2'] controller:Positive_regulationtLe1: trigger-arg-path: modulates >nsubj [lemma='mtorc2'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj controller:Positive_regulationt5e1: ents2Label-mention-ngram: enhances subsequent Aktt0e2: ents2Label-mention-ngram: response to growtht'e1: ents2Label-mention-ngram: modulatest,e1: ents2Label-mention-ngram: growth factorst%e1: ents2Label-mention-ngram: factorst$e1: args2Role-mention-ngram: factorstoe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj controllertFe1: trigger-arg-path: modulates >nsubj controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: on Thr308t)e1: ents2Label-mention-ngram: survival int|e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_regulation >nsubj [lemma='mtorc2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='mtorc2'] Positive_regulationt'e2: ents2Label-mention-ngram: SHARED ontWe1: trigger-arg-path: modulates >nsubj [lemma='mtorc2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='mtorc2'] Positive_regulationt;e2: args2Role-mention-ngram: enhances subsequent CONTROLLEDt+e1: args2Role-mention-ngram: modulates cellt?e2: trigger-arg-path: enhances nsubj [lemma='mtorc2'] controllertnsubj Positive_regulationt7e2: ents2Label-mention-ngram: phosphorylation on Thr308t6e1: args2Role-mention-ngram: CONTROLLER modulates celltEe1: trigger-arg-path: modulates:Positive_regulation >nsubj controllert.e2: ents2Label-mention-ngram: cell survival int,e1: ents2Label-mention-ngram: subsequent Aktt6e2: args2Role-mention-ngram: which enhances subsequentt5e1: ents2Label-mention-ngram: modulates cell survivalt/e1: ents2Label-mention-ngram: to growth factorst(e2: ents2Label-mention-ngram: factors byt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='mtorc2'] controllert+e1: ents2Label-mention-ngram: cell survivaltre2: trigger-arg-path: enhances:Positive_regulation nsubj controller:Positive_regulationt/e2: ents2Label-mention-ngram: growth factors bytke1: trigger-arg-path: modulates:Positive_regulation >nsubj [lemma='mtorc2'] controller:Gene_or_gene_productt(shortest-path: nsubj controllert(e1: args2Role-mention-ngram: survival int4e1: ents2Label-mention-ngram: Akt phosphorylation ont'e2: args2Role-mention-ngram: subsequentt,e2: ents2Label-mention-ngram: growth factorst"e1: ents2Label-mention-ngram: cellt-e2: args2Role-mention-ngram: CONTROLLER whicht7e1: ents2Label-mention-ngram: phosphorylation on Thr308t$e2: ents2Label-mention-ngram: growthtqe1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_regulation >nsubj [lemma='mtorc2'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED ont]e1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='mtorc2'] Gene_or_gene_productt?e2: trigger-arg-path: enhances:Positive_regulation nsubj [lemma='mtorc2'] controllert?e2: trigger-arg-path: enhances nsubj [lemma='mtorc2'] Positive_regulationt.e2: ents2Label-mention-ngram: SHARED on Ser473t'e2: ents2Label-mention-ngram: to growtht.e1: ents2Label-mention-ngram: cell survival int8e2: ents2Label-mention-ngram: factors by phosphorylatingt2e2: ents2Label-mention-ngram: survival in responset6e2: args2Role-mention-ngram: CONTROLLER which enhancestLe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_regulation >nsubj Gene_or_gene_productt,e1: ents2Label-mention-ngram: which enhanceste1: trigger: modulatest/e2: ents2Label-mention-ngram: subsequent SHAREDtBe1: trigger-arg-path: modulates >nsubj [lemma='mtorc2'] controllert.e1: args2Role-mention-ngram: growth factors byt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='mtorc2'] controllert7e2: ents2Label-mention-ngram: which enhances subsequentt(e1: ents2Label-mention-ngram: factors byt$e1: ents2Label-mention-ngram: Thr308t3e1: ents2Label-mention-ngram: Ser473 which enhancest,e1: ents2Label-mention-ngram: modulates cellt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='mtorc2'] Positive_regulationt#e1: args2Role-mention-ngram: growththe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='mtorc2'] controller:Gene_or_gene_producttJe2: trigger-arg-path: enhances nsubj controllertae1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtorc2'] controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: Ser473t7e2: ents2Label-mention-ngram: phosphorylating SHARED ont1e2: ents2Label-mention-ngram: enhances subsequentt'e2: ents2Label-mention-ngram: on Ser473t?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj [lemma='mtorc2'] controller:Positive_regulationt(e1: ents2Label-mention-ngram: subsequentt/e1: args2Role-mention-ngram: response to growtht.e2: ents2Label-mention-ngram: SHARED modulatest2e1: args2Role-mention-ngram: factors by CONTROLLEDtZe1: trigger-arg-path: modulates:Positive_regulation >nsubj controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: to growtht5e2: ents2Label-mention-ngram: modulates cell survivalt3e2: ents2Label-mention-ngram: SHARED modulates celltUe2: trigger-arg-path: Positive_regulation nsubj controllert3e1: ents2Label-mention-ngram: SHARED modulates cellt-e2: ents2Label-mention-ngram: on Ser473 whicht'e1: args2Role-mention-ngram: factors bytSe2: trigger-arg-path: enhances nsubj Positive_regulationt7e2: ents2Label-mention-ngram: SHARED phosphorylation ontde2: trigger-arg-path: lemmatizedTrigger=enhance nsubj Positive_regulationt&e1: args2Role-mention-ngram: modulatestLe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtorc2'] controllert-e1: args2Role-mention-ngram: cell survival int*e1: args2Role-mention-ngram: cell survivalt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation nsubj controller:Positive_regulationt+e1: args2Role-mention-ngram: growth factorst e1: ents2Label-mention-ngram: ont*e1: ents2Label-mention-ngram: Ser473 whicht3e2: ents2Label-mention-ngram: Ser473 which enhancest7e1: ents2Label-mention-ngram: which enhances subsequenttBe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj controllert?e2: trigger-arg-path: Positive_regulation nsubj [lemma='mtorc2'] controller:Positive_regulationtie2: trigger-arg-path: Positive_regulation nsubj controller:Positive_regulationt^e2: trigger-arg-path: Positive_regulation nsubj Positive_regulationt'e2: ents2Label-mention-ngram: modulatest?trigger-to-trigger-path: e1:modulates:Positive_regulation >prepc_by [lemma='phosphorylate'] >prep_on [lemma='ser473'] >rcmod [lemma='enhance'] e2:enhances:Positive_regulationt&e1: ents2Label-mention-ngram: its cellt e1: args2Role-mention-ngram: Lrpt}e2: trigger-arg-path: Positive_regulation prep_by [lemma='gsk3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] Gene_or_gene_productt$e1: args2Role-mention-ngram: and Lrpt,e1: ents2Label-mention-ngram: 6 inhibits thet%e1: ents2Label-mention-ngram: and Lrpt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] controllert:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and Lrpt&e1: args2Role-mention-ngram: and Lrp 5t$shortest-path: dobjtDe1: ents2Label-mention-ngram: surface receptors GENE_OR_GENE_PRODUCTtbshortest-path: dobj [lemma='phosphorylation']txe2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] controllertve2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='gsk3beta'] controllert$e1: ents2Label-mention-ngram: to itst%e1: ents2Label-mention-ngram: surfacete1: args2Role-mention-ngram: 6te1: ents2Label-mention-ngram: 5tne2: trigger-arg-path: phosphorylation prep_by [lemma='gsk3beta'] Gene_or_gene_productt+e1: args2Role-mention-ngram: and 6 inhibitstprep_by [lemma='gsk3beta'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: Lrpt:e1: ents2Label-mention-ngram: inhibits the phosphorylationt(e1: ents2Label-mention-ngram: 6 inhibitstye2: trigger-arg-path: phosphorylation prep_by [lemma='gsk3beta'] controller:Gene_or_gene_producttde2: trigger-arg-path: phosphorylation prep_by [lemma='gsk3beta'] controllert+e1: ents2Label-mention-ngram: FAMILY to itst%e1: ents2Label-mention-ngram: 5 and 6t&e1: args2Role-mention-ngram: Lrp 5 andte1: args2Role-mention-ngram: 5t$e1: args2Role-mention-ngram: 5 and 6t.e1: ents2Label-mention-ngram: its cell surfacet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='gsk3beta'] controller:Gene_or_gene_productthe2: trigger-arg-path: Positive_regulation prep_by [lemma='gsk3beta'] controllert+e1: args2Role-mention-ngram: 6 inhibits thet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='gsk3beta'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: Lrp 5 andt,e1: ents2Label-mention-ngram: and 6 inhibitst'e1: args2Role-mention-ngram: 6 inhibitst/e1: ents2Label-mention-ngram: surface receptorst)e1: ents2Label-mention-ngram: to its cellt#e1: ents2Label-mention-ngram: 5 andt4e1: ents2Label-mention-ngram: cell surface receptorst"e1: args2Role-mention-ngram: 5 andt@e1: ents2Label-mention-ngram: receptors GENE_OR_GENE_PRODUCT andt"e1: args2Role-mention-ngram: and 6t#e1: ents2Label-mention-ngram: and 6tre2: trigger-arg-path: Positive_regulation prep_by [lemma='gsk3beta'] Gene_or_gene_productte1: ents2Label-mention-ngram: 6t'e1: ents2Label-mention-ngram: FAMILY tot*e1: ents2Label-mention-ngram: cell surfacet&interceding-token ngrams: perturbationt?trigger-to-trigger-path: e1:complex:Binding nsubj [lemma='perturbation'] >prep_of [lemma='interaction'] e2:interaction:Bindingt7e1: trigger-arg-path: complex >nn [lemma='cdc25'] themet!interceding-token ngrams: oxidanttinterceding-token ngrams: Kt'interceding-token ngrams: complex , thetqtrigger-to-trigger-path: e1:complex:Binding nsubj >prep_of e2:interaction:Bindingt)interceding-token ngrams: the oxidant fort!interceding-token ngrams: ternaryt%interceding-token ngrams: that of thetFe1: trigger-arg-path: complex >nn [lemma='cdc25'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] themet+interceding-token ngrams: ternary complex ,t#interceding-token ngrams: of the wtt`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] Gene_or_gene_productt%interceding-token ngrams: the oxidanttIe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] themetinterceding-token ngrams: I oftyinterceding-tokens-full-span: and that of the app K I of the oxidant for the ternary complex , the perturbation of the wttLe1: trigger-arg-path: complex >nn [lemma='cdc25'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding >nn [lemma='cdc25'] Gene_or_gene_productt)interceding-token ngrams: for the ternarytXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttinterceding-token ngrams: app Kt interceding-token ngrams: the wtt%interceding-token ngrams: the ternaryt!interceding-token ngrams: app K It-interceding-token ngrams: perturbation of thet!interceding-token ngrams: the apptinterceding-token ngrams: wttNe1: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] Gene_or_gene_productt%interceding-token ngrams: oxidant fortAshortest-path: nsubj >prep_of >nnt^e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] theme:Gene_or_gene_producttinterceding-token ngrams: It?e1: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] themet interceding-token ngrams: K I oft(interceding-token ngrams: of the oxidanttLe1: trigger-arg-path: Binding >nn [lemma='cdc25'] theme:Gene_or_gene_productt)interceding-token ngrams: oxidant for thet"interceding-token ngrams: I of thet%interceding-token ngrams: and that oft)interceding-token ngrams: perturbation oft?shortest-path: nsubj [lemma='perturbation'] >prep_of [lemma='interaction'] >nn [lemma='ra']tinterceding-token ngrams: K It-interceding-token ngrams: the perturbation oft#interceding-token ngrams: the app Ktinterceding-token ngrams: appt,interceding-token ngrams: , the perturbationt$interceding-token ngrams: of the apptTe1: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_productt)interceding-token ngrams: ternary complext7e1: trigger-arg-path: Binding >nn [lemma='cdc25'] themet-interceding-token ngrams: the ternary complext*interceding-token ngrams: the perturbationt;e2: trigger-arg-path: associated e1: trigger-arg-path: Binding e2: trigger-arg-path: Binding ccomp Bindingtwe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] Familytbe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj >nn controller:Familytge1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='activity'] >nn [lemma='ra'] controllertRe1: trigger-arg-path: stimulated:Positive_regulation >ccomp [lemma='bind'] Bindingt+e2: ents2Label-mention-ngram: hydrolysis oftjtrigger-to-trigger-path: e1:stimulated:Positive_regulation >ccomp >nsubj e2:hydrolysis:Positive_regulationtNe1: trigger-arg-path: stimulated:Positive_regulation >ccomp controlled:BindingtMe2: trigger-arg-path: hydrolysis:Positive_regulation >nn Gene_or_gene_producttCe1: trigger-arg-path: Positive_regulation >ccomp controlled:Bindingt2e2: ents2Label-mention-ngram: SHARED hydrolysis oft/e1: ents2Label-mention-ngram: by preventing GAPt-e1: ents2Label-mention-ngram: GTPase activityt,e1: ents2Label-mention-ngram: GAP stimulatedt3e1: args2Role-mention-ngram: activity by preventingt5e1: args2Role-mention-ngram: hydrolysis of CONTROLLEDt4e1: ents2Label-mention-ngram: FAMILY GTPase activitytRe1: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] controlled:BindingtGe2: trigger-arg-path: hydrolysis >nn [lemma='gtp'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: by preventingtQe1: trigger-arg-path: stimulated:Positive_regulation >nsubj >nn controller:Familyt>e1: trigger-arg-path: stimulated >ccomp [lemma='bind'] Bindingt8e1: trigger-arg-path: Positive_regulation >ccomp Bindingt4e1: ents2Label-mention-ngram: activity by preventingtJe1: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] controlledtCe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >nn Familyt.e1: args2Role-mention-ngram: CONTROLLER GTPasetxe2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn [lemma='gtp'] controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:stimulated:Positive_regulation >ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] e2:hydrolysis:Positive_regulationtAe2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn controllert-e1: ents2Label-mention-ngram: of SHARED boundt6e1: args2Role-mention-ngram: stimulated GTP hydrolysistVe2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED bound activatedt=e1: trigger-arg-path: stimulated >nsubj >nn controller:FamilytWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp controlledt/e1: args2Role-mention-ngram: GTPase activity bytRe1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp [lemma='bind'] controlledt-e1: ents2Label-mention-ngram: bound activatedtce1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='activity'] >nn [lemma='ra'] Familyt=e2: trigger-arg-path: hydrolysis >nn [lemma='gtp'] controllert{e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controllert]e1: trigger-arg-path: stimulated >nsubj [lemma='activity'] >nn [lemma='ra'] controller:Familyte1: trigger: stimulatedt+e1: args2Role-mention-ngram: GTP hydrolysistKe2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn Gene_or_gene_productt;e1: trigger-arg-path: Positive_regulation >ccomp controlledt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controllertOe2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn [lemma='gtp'] controllertFe2: trigger-arg-path: Positive_regulation >nn [lemma='gtp'] controllertZe1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp [lemma='bind'] controlled:Bindingt2e1: trigger-arg-path: stimulated >nsubj >nn Familyt e1: args2Role-mention-ngram: GAPtNe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >nn controller:FamilytFe1: trigger-arg-path: stimulated:Positive_regulation >ccomp controlledtne1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='activity'] >nn [lemma='ra'] controller:Familyt7e1: ents2Label-mention-ngram: preventing GAP stimulatedt/e1: ents2Label-mention-ngram: GTP hydrolysis oft_e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp controlled:Bindingt?shortest-path: ccomp [lemma='bind'] >nsubj [lemma='hydrolysis'] >nn [lemma='gtp']tce1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp [lemma='bind'] Bindingt0e1: ents2Label-mention-ngram: GTPase activity byt_e2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn [lemma='gtp'] Gene_or_gene_producttIe1: trigger-arg-path: stimulated >ccomp [lemma='bind'] controlled:Bindingt+e1: args2Role-mention-ngram: preventing GAPt[e2: trigger-arg-path: Positive_regulation >nn [lemma='gtp'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn [lemma='gtp'] Gene_or_gene_productt]e1: trigger-arg-path: stimulated:Positive_regulation >ccomp [lemma='bind'] controlled:BindingtJe1: trigger-arg-path: stimulated:Positive_regulation >nsubj >nn controllert+e1: args2Role-mention-ngram: stimulated GTPt@e1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp Bindingt7e1: args2Role-mention-ngram: CONTROLLER GTPase activityt'e1: args2Role-mention-ngram: preventingtVe1: trigger-arg-path: stimulated >nsubj [lemma='activity'] >nn [lemma='ra'] controllert+shortest-path: ccomp >nsubj >nntfe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp [lemma='bind'] controlledt*e1: args2Role-mention-ngram: by preventingtne1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp [lemma='bind'] controlled:BindingtKe1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp controlled:Bindingtfe1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] FamilytTe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >ccomp Bindingt#e1: args2Role-mention-ngram: GTPaset2e2: ents2Label-mention-ngram: hydrolysis of SHAREDt(e2: ents2Label-mention-ngram: hydrolysist(e1: ents2Label-mention-ngram: preventingt,e1: args2Role-mention-ngram: GTPase activitytWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj >nn FamilytUe1: trigger-arg-path: stimulated:Positive_regulation >ccomp [lemma='bind'] controlledt/e1: args2Role-mention-ngram: GAP stimulated GTPt.e1: args2Role-mention-ngram: by preventing GAPtXe2: trigger-arg-path: hydrolysis:Positive_regulation >nn controller:Gene_or_gene_producttGe1: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] Bindingt6e1: trigger-arg-path: stimulated >nsubj >nn controllert6e1: args2Role-mention-ngram: preventing GAP stimulatedt+e1: ents2Label-mention-ngram: FAMILY GTPasetAe1: trigger-arg-path: stimulated >ccomp [lemma='bind'] controlledtde2: trigger-arg-path: lemmatizedTrigger=hydrolysis >nn [lemma='gtp'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: GTP hydrolysistqe1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controller:Familyt+e1: args2Role-mention-ngram: GAP stimulatedt9e2: trigger-arg-path: hydrolysis >nn Gene_or_gene_productt[e2: trigger-arg-path: hydrolysis:Positive_regulation >nn [lemma='gtp'] Gene_or_gene_producttFe1: trigger-arg-path: stimulated:Positive_regulation >nsubj >nn FamilytPe2: trigger-arg-path: Positive_regulation >nn [lemma='gtp'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp [lemma='bind'] BindingtCe1: trigger-arg-path: lemmatizedTrigger=stimulate >ccomp controlledt/e2: trigger-arg-path: hydrolysis >nn controllertDe2: trigger-arg-path: hydrolysis >nn controller:Gene_or_gene_productt[e1: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] Familyt:e1: trigger-arg-path: stimulated >ccomp controlled:Bindingte2: trigger: hydrolysistUe2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn controllert0e1: ents2Label-mention-ngram: GAP stimulated GTPtfe2: trigger-arg-path: hydrolysis:Positive_regulation >nn [lemma='gtp'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: stimulatedtRe1: trigger-arg-path: stimulated >nsubj [lemma='activity'] >nn [lemma='ra'] Familyt,e1: ents2Label-mention-ngram: preventing GAPtCe1: trigger-arg-path: stimulated:Positive_regulation >ccomp BindingtCe2: trigger-arg-path: hydrolysis:Positive_regulation >nn controllertQe2: trigger-arg-path: hydrolysis:Positive_regulation >nn [lemma='gtp'] controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controller:Familyt2e1: ents2Label-mention-ngram: hydrolysis of SHAREDt/e2: ents2Label-mention-ngram: SHARED hydrolysist,e1: ents2Label-mention-ngram: stimulated GTPtce2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn [lemma='gtp'] controllertRe2: trigger-arg-path: hydrolysis >nn [lemma='gtp'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: bound activated FAMILYt7e1: ents2Label-mention-ngram: stimulated GTP hydrolysist.e1: args2Role-mention-ngram: GTP hydrolysis oft.e1: ents2Label-mention-ngram: activated FAMILYtfe1: trigger-arg-path: Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controller:Familytje1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='activity'] >nn [lemma='ra'] controllertje2: trigger-arg-path: lemmatizedTrigger=hydrolysis:Positive_regulation >nn controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: GAPt2e1: trigger-arg-path: stimulated >ccomp controlledt@e1: trigger-arg-path: binding >prep_of [lemma='ra'] theme:FamilytWe2: trigger-arg-path: Negative_regulation >nn [lemma='calmodulin'] Gene_or_gene_productt9e2: trigger-arg-path: inhibition >nn Gene_or_gene_productt9e1: trigger-arg-path: binding >prep_of [lemma='ra'] themet5e2: args2Role-mention-ngram: inhibition of CONTROLLEDt-e1: trigger-arg-path: binding >prep_of Familyt[e1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] themet9e1: trigger-arg-path: Binding >prep_of [lemma='ra'] themetXe2: trigger-arg-path: inhibition:Negative_regulation >nn controller:Gene_or_gene_productt,interceding-token ngrams: 2+ suppressed thistTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] Familyt*interceding-token ngrams: Ca 2+ suppressedt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibitiontme1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] themetNe2: trigger-arg-path: inhibition >nn [lemma='calmodulin'] Gene_or_gene_producttme2: trigger-arg-path: inhibition:Negative_regulation >nn [lemma='calmodulin'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: THEME totje2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn [lemma='calmodulin'] controllert5e2: args2Role-mention-ngram: CONTROLLER inhibition oft(shortest-path: conj_and >dobj >nnt'interceding-token ngrams: 2+ suppressedtMe2: trigger-arg-path: inhibition:Negative_regulation >nn Gene_or_gene_productt*e2: args2Role-mention-ngram: inhibition oftEe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of theme:Familytinterceding-token ngrams: 2+t@e1: trigger-arg-path: Binding >prep_of [lemma='ra'] theme:Familyt:e1: trigger-arg-path: binding >prep_of [lemma='ra'] Familytbe2: trigger-arg-path: Negative_regulation >nn [lemma='calmodulin'] controller:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn [lemma='calmodulin'] Gene_or_gene_producttYe2: trigger-arg-path: inhibition >nn [lemma='calmodulin'] controller:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] themetDe2: trigger-arg-path: inhibition >nn [lemma='calmodulin'] controllertDe2: trigger-arg-path: inhibition >nn controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] Gene_or_gene_producttctrigger-to-trigger-path: e1:binding:Binding conj_and >dobj e2:inhibition:Negative_regulationtinterceding-token ngrams: Ca 2+twshortest-path: conj_and [lemma='suppress'] >dobj [lemma='inhibition'] >nn [lemma='calmodulin']tBe1: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] Familytprep_to [lemma='raf1'] Gene_or_gene_productt8e2: trigger-arg-path: Negative_regulation >nn controllertMe2: trigger-arg-path: Negative_regulation >nn [lemma='calmodulin'] controllertje2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn controller:Gene_or_gene_productt!interceding-token ngrams: that CatSe1: trigger-arg-path: Binding prep_to [lemma='raf1'] themetpe1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] Familyte2: trigger: inhibitionthe1: trigger-arg-path: binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt/e2: trigger-arg-path: inhibition >nn controllertGe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of Familyt|e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] theme:FamilytVe2: trigger-arg-path: lemmatizedTrigger=inhibition >nn [lemma='calmodulin'] controllertHe1: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] theme:Familytbe1: trigger-arg-path: binding prep_to [lemma='raf1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME to THEMEt3e1: trigger-arg-path: binding >prep_of theme:Familyt)interceding-token ngrams: suppressed thist:e1: trigger-arg-path: Binding >prep_of [lemma='ra'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn Gene_or_gene_productt5e1: trigger-arg-path: binding:Binding >prep_of FamilytMe2: trigger-arg-path: Negative_regulation >nn controller:Gene_or_gene_productt%interceding-token ngrams: and that Cat$interceding-token ngrams: that Ca 2+tKe2: trigger-arg-path: lemmatizedTrigger=inhibition >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of FamilytCe2: trigger-arg-path: inhibition:Negative_regulation >nn controllert$interceding-token ngrams: suppressedt-e1: trigger-arg-path: Binding >prep_of Familyt(e1: args2Role-mention-ngram: of THEME totBe2: trigger-arg-path: Negative_regulation >nn Gene_or_gene_producttAe1: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] themetMe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of theme:FamilytVe2: trigger-arg-path: lemmatizedTrigger=inhibition >nn controller:Gene_or_gene_productt3e1: trigger-arg-path: Binding >prep_of theme:FamilytKe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] themet`e2: trigger-arg-path: lemmatizedTrigger=inhibition >nn [lemma='calmodulin'] Gene_or_gene_producttXe2: trigger-arg-path: inhibition:Negative_regulation >nn [lemma='calmodulin'] controllerte2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn [lemma='calmodulin'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibition:Negative_regulation >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] themetze1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=inhibition >nn [lemma='calmodulin'] controller:Gene_or_gene_productt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibition oftAe2: trigger-arg-path: lemmatizedTrigger=inhibition >nn controllertSe1: trigger-arg-path: binding prep_to [lemma='raf1'] themetRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] theme:Familyt?trigger-to-trigger-path: e1:binding:Binding conj_and [lemma='suppress'] >dobj [lemma='inhibition'] e2:inhibition:Negative_regulationtbe2: trigger-arg-path: inhibition:Negative_regulation >nn [lemma='calmodulin'] Gene_or_gene_producttinterceding-token ngrams: Cathe1: trigger-arg-path: Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt;e1: trigger-arg-path: binding:Binding >prep_of theme:Familytje1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt&interceding-token ngrams: conditions ,tde2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT promotes thetDe2: trigger-arg-path: ubiquitinates >nsubj [lemma='mdm2'] controllertJe2: trigger-arg-path: ubiquitinates >nsubj controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] controllert?e2: trigger-arg-path: ubiquitinates >nsubj Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj controller:Gene_or_gene_productt>e1: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCT promotest5e2: trigger-arg-path: ubiquitinates >nsubj controllertPe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj Gene_or_gene_productt interceding-token ngrams: stresst~e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt^e2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj controller:Gene_or_gene_productte2: trigger: ubiquitinatestie2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] controllertgtrigger-to-trigger-path: e1:promotes:Positive_regulation >conj_and e2:ubiquitinates:Positive_regulationt+interceding-token ngrams: stress conditionst*interceding-token ngrams: conditions , andtYe2: trigger-arg-path: ubiquitinates >nsubj [lemma='mdm2'] controller:Gene_or_gene_producttme2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: ubiquitinates SHAREDt6e1: ents2Label-mention-ngram: promotes the interactiont4e1: args2Role-mention-ngram: CONTROLLER promotes thet0e1: args2Role-mention-ngram: CONTROLLER promotestIe2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj controllert;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT promotest^shortest-path: conj_and [lemma='ubiquitinate'] >nsubj [lemma='mdm2']t&interceding-token ngrams: under stresst@interceding-tokens-full-span: under stress conditions , and thattbe2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_productt~trigger-to-trigger-path: e1:promotes:Positive_regulation >conj_and [lemma='ubiquitinate'] e2:ubiquitinates:Positive_regulationt+e2: ents2Label-mention-ngram: ubiquitinatestZe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj controllert9e2: ents2Label-mention-ngram: SHARED ubiquitinates SHAREDt2e2: ents2Label-mention-ngram: SHARED ubiquitinatestXe2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj [lemma='mdm2'] controllertFe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj controllert4e1: args2Role-mention-ngram: promotes the CONTROLLEDt-interceding-token ngrams: stress conditions ,t_e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >nsubj [lemma='mdm2'] Gene_or_gene_producttNe2: trigger-arg-path: ubiquitinates >nsubj [lemma='mdm2'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_producttSe2: trigger-arg-path: ubiquitinates:Positive_regulation >nsubj Gene_or_gene_productt1interceding-token ngrams: under stress conditionstEe1: trigger-arg-path: increases:Negative_regulation >ccomp controlledtNe1: trigger-arg-path: increases:Negative_regulation >nsubj >prep_of controllertEe1: trigger-arg-path: increases >ccomp controlled:Positive_regulationt8e2: ents2Label-mention-ngram: induced SHARED acetylationtje1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp controlled:Positive_regulationtYe2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='acetylation'] AcetylationtLe2: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] controllert@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT increases DNAt'e1: ents2Label-mention-ngram: increasestNe1: trigger-arg-path: increases:Negative_regulation >ccomp Positive_regulationt2e1: ents2Label-mention-ngram: increases DNA SHAREDtOe1: trigger-arg-path: increases >nsubj >prep_of controller:Gene_or_gene_producttNe2: trigger-arg-path: induced:Positive_regulation >dobj controlled:AcetylationtVe1: trigger-arg-path: increases:Negative_regulation >ccomp [lemma='induce'] controlledtDe2: trigger-arg-path: induced >dobj [lemma='acetylation'] controlledt1e1: args2Role-mention-ngram: CONTROLLER increasestde2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='acetylation'] controlled:Acetylationt*e1: args2Role-mention-ngram: increases DNAt/e2: trigger-arg-path: induced >dobj Acetylationt^e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttptrigger-to-trigger-path: e1:increases:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='damage'] controller:Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='acetylation'] controlled:AcetylationtYe1: trigger-arg-path: increases:Negative_regulation >ccomp controlled:Positive_regulationtEe2: trigger-arg-path: induced >dobj [lemma='acetylation'] AcetylationtKe2: trigger-arg-path: lemmatizedTrigger=induce >dobj controlled:Acetylationt:e1: trigger-arg-path: increases >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: increases:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controller:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtce1: trigger-arg-path: increases:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttUe2: trigger-arg-path: induced >nsubj [lemma='damage'] controller:Gene_or_gene_producttDe1: trigger-arg-path: increases >nsubj >prep_of Gene_or_gene_productt}e1: trigger-arg-path: increases:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=induce >dobj AcetylationtVe2: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttCe2: trigger-arg-path: induced:Positive_regulation >dobj AcetylationtBe1: trigger-arg-path: increases >ccomp [lemma='induce'] controlledtie2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='acetylation'] Acetylationtge1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp [lemma='induce'] controlledt:e1: trigger-arg-path: increases >ccomp Positive_regulationtoe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp controlledtze1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] Gene_or_gene_productt_e1: trigger-arg-path: increases >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controllertQe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='damage'] controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controllertte1: trigger-arg-path: increases >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controller:Gene_or_gene_producttdobj [lemma='acetylation'] controlled:Acetylationt+e1: args2Role-mention-ngram: DNA CONTROLLEDt{e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt_e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controlled:Acetylationt0e1: ents2Label-mention-ngram: DNA SHARED inducedt:e2: trigger-arg-path: induced >dobj controlled:AcetylationtXe2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='acetylation'] controlledt_trigger-to-trigger-path: e1:increases:Negative_regulation >ccomp e2:induced:Positive_regulationtVe1: trigger-arg-path: increases >ccomp [lemma='induce'] controlled:Positive_regulationt(e1: ents2Label-mention-ngram: DNA SHAREDt1e1: trigger-arg-path: increases >ccomp controlledtVe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='acetylation'] Acetylationt~e1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controller:Gene_or_gene_producttje1: trigger-arg-path: increases:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtKe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp Positive_regulationtUe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='acetylation'] controlledt8e1: ents2Label-mention-ngram: induced SHARED acetylationtKe1: trigger-arg-path: increases >ccomp [lemma='induce'] Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controller:Gene_or_gene_producttse1: trigger-arg-path: increases:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controllertse1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] Gene_or_gene_producttie1: trigger-arg-path: increases >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] controlledte1: trigger: increasestee2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='damage'] controllert+e1: ents2Label-mention-ngram: increases DNAtVe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp controlled:Positive_regulationtTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj Acetylationtue2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='acetylation'] controlled:AcetylationtTe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='damage'] controllert\e1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] Positive_regulationt_e1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp Positive_regulationtJe2: trigger-arg-path: induced >nsubj [lemma='damage'] Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER increases DNAtie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='acetylation'] controlledt[e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='damage'] Gene_or_gene_producttie1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controllertpe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='expression'] >prep_of [lemma='hdac1'] controllertge1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] controlled:Positive_regulationtvshortest-path: ccomp [lemma='induce'] >nsubj [lemma='damage']t&e1: args2Role-mention-ngram: increasest5e1: args2Role-mention-ngram: increases DNA CONTROLLEDtVe1: trigger-arg-path: lemmatizedTrigger=increase:Negative_regulation >ccomp controlledt@e2: trigger-arg-path: induced >nsubj [lemma='damage'] controllert_e1: trigger-arg-path: increases:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtXe1: trigger-arg-path: increases:Negative_regulation >nsubj >prep_of Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent controllert(e1: ents2Label-mention-ngram: FAMILY andt;e2: trigger-arg-path: Positive_activation >agent controllert%e1: ents2Label-mention-ngram: for R68t?e1: trigger-arg-path: lemmatizedTrigger=interaction dobj [lemma='role'] >prep_for [lemma='r68'] Sitet'e1: ents2Label-mention-ngram: showed notPe1: trigger-arg-path: interactions:Binding >prep_between [lemma='gap-334'] themetJe1: trigger-arg-path: interactions >prep_between [lemma='ra'] theme:Familyt&e1: ents2Label-mention-ngram: role fortGe1: trigger-arg-path: interactions dobj >prep_for sitet"e1: ents2Label-mention-ngram: rolet_e1: trigger-arg-path: interactions:Binding >prep_between [lemma='gap-334'] Gene_or_gene_producttVe2: trigger-arg-path: stimulated >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlledt.e2: ents2Label-mention-ngram: be stimulated bytfe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass >nn controlled:FamilytPe2: trigger-arg-path: stimulated:Positive_activation >agent Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_for sitet/e2: ents2Label-mention-ngram: can be stimulatedtKe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass >nn controlledt!e2: args2Role-mention-ngram: R68QtXe1: trigger-arg-path: Binding >prep_between [lemma='gap-334'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='gap'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: R68Q cant^e2: trigger-arg-path: stimulated:Positive_activation >agent [lemma='gap'] Gene_or_gene_producttDe1: trigger-arg-path: interactions >prep_between [lemma='ra'] Familyt#e1: args2Role-mention-ngram: showedt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlled:Familyt[e2: trigger-arg-path: Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass >nn controlledtee1: trigger-arg-path: interactions:Binding >prep_between [lemma='gap-334'] theme:Gene_or_gene_producttje2: trigger-arg-path: stimulated:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlledt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_for SitetEe1: trigger-arg-path: interactions:Binding >prep_between theme:FamilytVe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between theme:Familytie2: trigger-arg-path: stimulated:Positive_activation >agent [lemma='gap'] controller:Gene_or_gene_productt?e1: trigger-arg-path: Binding dobj [lemma='role'] >prep_for [lemma='r68'] sitetHe1: trigger-arg-path: interactions >prep_between [lemma='gap-334'] themetYe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gap-334'] themete1: args2Role-mention-ngram: not,e1: ents2Label-mention-ngram: between FAMILYt?trigger-to-trigger-path: e1:interactions:Binding dobj [lemma='role'] >prep_for [lemma='r68'] >prep_of [lemma='ra'] >vmod [lemma='explain'] >advcl [lemma='stimulate'] e2:stimulated:Positive_activationtGe1: trigger-arg-path: interactions dobj >prep_for Sitet?e1: trigger-arg-path: interactions dobj [lemma='role'] >prep_for [lemma='r68'] site:Sitet2e1: trigger-arg-path: Binding >prep_between FamilytNe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between theme:Familyt?e1: trigger-arg-path: interactions:Binding dobj [lemma='role'] >prep_for [lemma='r68'] sitet=e1: trigger-arg-path: interactions >prep_between theme:FamilytBe1: trigger-arg-path: Binding dobj >prep_for sitetXe1: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_for Sitet=e1: ents2Label-mention-ngram: FAMILY and GENE_OR_GENE_PRODUCTt*e1: ents2Label-mention-ngram: role for R68t!e1: ents2Label-mention-ngram: R68t@e2: ents2Label-mention-ngram: stimulated by GENE_OR_GENE_PRODUCTtJe2: trigger-arg-path: stimulated:Positive_activation >nsubjpass >nn Familytoe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent [lemma='gap'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='r68q'] >nn [lemma='ra'] Familyt&interceding-token ngrams: , explainingt[e2: trigger-arg-path: stimulated:Positive_activation >agent controller:Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation >agent controller:Gene_or_gene_productt?e1: trigger-arg-path: interactions dobj [lemma='role'] >prep_for [lemma='r68'] sitetwe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] FamilytRe1: trigger-arg-path: Binding >prep_between [lemma='gap-334'] Gene_or_gene_productt?trigger-to-trigger-path: e1:interactions:Binding dobj >prep_for >prep_of >vmod >advcl e2:stimulated:Positive_activationtWe1: trigger-arg-path: interactions >prep_between [lemma='gap-334'] Gene_or_gene_producttRe1: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] theme:FamilytEe2: trigger-arg-path: Positive_activation >agent Gene_or_gene_productt?e1: trigger-arg-path: Binding dobj [lemma='role'] >prep_for [lemma='r68'] site:Sitet?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='role'] >prep_for [lemma='r68'] site:Sitet"e2: ents2Label-mention-ngram: R68Qt)e2: ents2Label-mention-ngram: R68Q can betCe1: trigger-arg-path: interactions >prep_between [lemma='ra'] themetze2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent [lemma='gap'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='role'] >prep_for [lemma='r68'] sitetae1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gap-334'] themet,e1: args2Role-mention-ngram: THEME showed notNe2: trigger-arg-path: stimulated:Positive_activation >nsubjpass >nn controlledt_e2: trigger-arg-path: Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent controllertge2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlledt?e1: trigger-arg-path: Binding >prep_between [lemma='ra'] FamilytRe2: trigger-arg-path: stimulated >nsubjpass [lemma='r68q'] >nn [lemma='ra'] Familyt?e1: trigger-arg-path: Binding dobj [lemma='role'] >prep_for [lemma='r68'] Sitetpe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gap-334'] Gene_or_gene_producttCe2: trigger-arg-path: Positive_activation >nsubjpass >nn controlledtfe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='gap'] controller:Gene_or_gene_producttagent Gene_or_gene_productt=e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT showedtfe2: trigger-arg-path: stimulated:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] Familyt6e2: trigger-arg-path: stimulated >nsubjpass >nn Familytfe2: trigger-arg-path: Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlled:FamilytLe1: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] Familyt?e1: trigger-arg-path: interactions:Binding dobj [lemma='role'] >prep_for [lemma='r68'] site:Sitet-e2: args2Role-mention-ngram: be stimulated byt)e2: ents2Label-mention-ngram: FAMILY R68QtKe1: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] themetinterceding-token ngrams: whytdobj [lemma='role'] >prep_for [lemma='r68'] site:Sitet!e1: args2Role-mention-ngram: roletHe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between FamilytTe1: trigger-arg-path: interactions:Binding dobj >prep_for site:SitetTe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] themetMe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent Gene_or_gene_productt-e2: ents2Label-mention-ngram: FAMILY R68Q cant?e1: trigger-arg-path: interactions:Binding dobj [lemma='role'] >prep_for [lemma='r68'] Sitet[e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] theme:Familyt*e1: args2Role-mention-ngram: role for SITEtee2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent [lemma='gap'] controllert0e1: ents2Label-mention-ngram: between FAMILY andt]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] FamilytOe1: trigger-arg-path: interactions:Binding dobj >prep_for sitet?e1: trigger-arg-path: interactions dobj [lemma='role'] >prep_for [lemma='r68'] SitetEe1: trigger-arg-path: Binding >prep_between [lemma='ra'] theme:Familyt@e2: trigger-arg-path: stimulated >agent [lemma='gap'] controllert,e1: ents2Label-mention-ngram: showed no rolet?shortest-path: dobj [lemma='role'] >prep_for [lemma='r68'] >prep_of [lemma='ra'] >vmod [lemma='explain'] >advcl [lemma='stimulate'] >nsubjpass [lemma='r68q'] >nn [lemma='ra']t?e1: trigger-arg-path: interactions:Binding >prep_between Familyt%e1: args2Role-mention-ngram: for SITEt]e2: trigger-arg-path: stimulated >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlled:Familytce1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] theme:Familyt2e2: trigger-arg-path: stimulated >agent controllert0e2: args2Role-mention-ngram: CONTROLLED R68Q cant$interceding-token ngrams: explainingtqe2: trigger-arg-path: stimulated:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlled:FamilytLe1: trigger-arg-path: interactions dobj >prep_for site:SitetFe2: trigger-arg-path: stimulated:Positive_activation >agent controllertsortest-path-dist: 9t(e2: args2Role-mention-ngram: R68Q can bet*e2: args2Role-mention-ngram: be stimulatedt]e1: trigger-arg-path: lemmatizedTrigger=interaction dobj >prep_for site:SitetTe2: trigger-arg-path: stimulated:Positive_activation >agent [lemma='gap'] controllertJe2: trigger-arg-path: stimulated >agent [lemma='gap'] Gene_or_gene_productt]e1: trigger-arg-path: interactions >prep_between [lemma='gap-334'] theme:Gene_or_gene_productt8e1: trigger-arg-path: Binding >prep_between theme:Familytne1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gap-334'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='gap'] controllertUe2: trigger-arg-path: stimulated:Positive_activation >nsubjpass >nn controlled:Familyt>e1: trigger-arg-path: Binding >prep_between [lemma='ra'] themetBe1: trigger-arg-path: Binding dobj >prep_for Sitet:e2: trigger-arg-path: stimulated >nsubjpass >nn controlledtle2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent controller:Gene_or_gene_productt(interceding-token ngrams: explaining whytUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ra'] FamilytAe2: trigger-arg-path: stimulated >nsubjpass >nn controlled:Familyt$e1: args2Role-mention-ngram: no rolet[e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass >nn Familyt&e1: args2Role-mention-ngram: showed not*interceding-token ngrams: , explaining whyt7e1: trigger-arg-path: interactions >prep_between FamilytRe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass >nn controlled:FamilytXe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent controller:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlledt(e1: args2Role-mention-ngram: no role fort^e2: trigger-arg-path: Positive_activation >agent [lemma='gap'] controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: interactions between FAMILYtPe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between Familyt5e2: args2Role-mention-ngram: stimulated by CONTROLLERtIe2: trigger-arg-path: Positive_activation >agent [lemma='gap'] controllert*interceding-token ngrams: Ras , explainingt\e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ra'] themet%e1: args2Role-mention-ngram: role fort+e2: ents2Label-mention-ngram: be stimulatedt?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj [lemma='role'] >prep_for [lemma='r68'] Sitet-e1: args2Role-mention-ngram: and THEME showedt5interceding-tokens-full-span: of Ras , explaining whyt,e2: args2Role-mention-ngram: CONTROLLED R68Qt?e1: trigger-arg-path: lemmatizedTrigger=interaction dobj [lemma='role'] >prep_for [lemma='r68'] sitet$e1: ents2Label-mention-ngram: showedtJe2: trigger-arg-path: Positive_activation >nsubjpass >nn controlled:FamilytOe1: trigger-arg-path: interactions:Binding dobj >prep_for Sitethe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gap-334'] Gene_or_gene_producttCe1: trigger-arg-path: Binding >prep_between [lemma='gap-334'] themetSshortest-path: dobj >prep_for >prep_of >vmod >advcl >nsubjpass >nnt.e2: args2Role-mention-ngram: can be stimulatedt%e1: ents2Label-mention-ngram: no rolet?e2: trigger-arg-path: Positive_activation >nsubjpass >nn Familytve1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gap-334'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT showedt%e2: args2Role-mention-ngram: R68Q cantee1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_for site:SitetSe2: trigger-arg-path: Positive_activation >agent [lemma='gap'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass [lemma='r68q'] >nn [lemma='ra'] controlled:FamilytGe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubjpass >nn Familyt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding dobj >prep_for sitet)e1: args2Role-mention-ngram: THEME showedtGe2: trigger-arg-path: stimulated >agent controller:Gene_or_gene_producttUe2: trigger-arg-path: stimulated >agent [lemma='gap'] controller:Gene_or_gene_productttrigger-dist: 7t+e1: args2Role-mention-ngram: showed no roletGe1: trigger-arg-path: Binding dobj >prep_for site:Sitetae2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >agent Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhances itst2e2: trigger-arg-path: acetylation >poss controllertDe2: trigger-arg-path: lemmatizedTrigger=acetylation >poss controllertXe2: trigger-arg-path: acetylation:Positive_regulation >poss [lemma='its'] Generic_entityt0e1: ents2Label-mention-ngram: SHARED sumoylationtfe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss [lemma='its'] controllert;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhancest)e1: ents2Label-mention-ngram: sumoylationt>e2: trigger-arg-path: Positive_regulation >poss Generic_entitytJe2: trigger-arg-path: acetylation:Positive_regulation >poss Generic_entityt%shortest-path: dobj >posst%e1: args2Role-mention-ngram: enhancest0e1: args2Role-mention-ngram: CONTROLLER enhancestge2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss controller:Generic_entitytce2: trigger-arg-path: acetylation:Positive_regulation >poss [lemma='its'] controller:Generic_entityt3e2: ents2Label-mention-ngram: SHARED acetylation oftwtrigger-to-trigger-path: e1:enhances:Positive_regulation >dobj [lemma='acetylation'] e2:acetylation:Positive_regulationtatrigger-to-trigger-path: e1:enhances:Positive_regulation >dobj e2:acetylation:Positive_regulationt,e1: ents2Label-mention-ngram: sumoylation bytOe2: trigger-arg-path: acetylation >poss [lemma='its'] controller:Generic_entityt6e1: ents2Label-mention-ngram: enhances its acetylationtje2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss [lemma='its'] Generic_entitytHe2: trigger-arg-path: Positive_regulation >poss [lemma='its'] controllertLe2: trigger-arg-path: Positive_regulation >poss [lemma='its'] Generic_entityt6e2: trigger-arg-path: acetylation >poss Generic_entitytue2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss [lemma='its'] controller:Generic_entityt3e1: ents2Label-mention-ngram: SHARED sumoylation bytIe2: trigger-arg-path: Positive_regulation >poss controller:Generic_entityt0e1: ents2Label-mention-ngram: its acetylation oftDe2: trigger-arg-path: acetylation >poss [lemma='its'] Generic_entityt4e1: args2Role-mention-ngram: CONTROLLER enhances itstRe2: trigger-arg-path: lemmatizedTrigger=acetylation >poss [lemma='its'] controllert)e1: args2Role-mention-ngram: enhances itste1: trigger: enhancestae2: trigger-arg-path: lemmatizedTrigger=acetylation >poss [lemma='its'] controller:Generic_entitytXe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss controllert:e2: trigger-arg-path: Positive_regulation >poss controllertFe2: trigger-arg-path: acetylation:Positive_regulation >poss controllertAe1: ents2Label-mention-ngram: sumoylation by GENE_OR_GENE_PRODUCTt>e1: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCT enhancest*e1: ents2Label-mention-ngram: enhances itstWe2: trigger-arg-path: Positive_regulation >poss [lemma='its'] controller:Generic_entitytUe2: trigger-arg-path: acetylation:Positive_regulation >poss controller:Generic_entitytHe2: trigger-arg-path: lemmatizedTrigger=acetylation >poss Generic_entitytAe2: trigger-arg-path: acetylation >poss controller:Generic_entityt@e2: trigger-arg-path: acetylation >poss [lemma='its'] controllertSe2: trigger-arg-path: lemmatizedTrigger=acetylation >poss controller:Generic_entityt4e1: args2Role-mention-ngram: enhances its CONTROLLEDtVe2: trigger-arg-path: lemmatizedTrigger=acetylation >poss [lemma='its'] Generic_entityt-e1: ents2Label-mention-ngram: its acetylationtqshortest-path: dobj [lemma='acetylation'] >poss [lemma='its']tTe2: trigger-arg-path: acetylation:Positive_regulation >poss [lemma='its'] controllert\e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >poss Generic_entityt&e1: ents2Label-mention-ngram: 21 ( S21tle2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation prep_for Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=inhibit prep_for [lemma='h3k27me3'] controller:Gene_or_gene_productt[e2: trigger-arg-path: inhibits:Negative_regulation nsubj [lemma='akt'] controller:Gene_or_gene_productt3e2: trigger-arg-path: inhibits >prep_for controllert1e2: ents2Label-mention-ngram: its enzyme activityt0e2: args2Role-mention-ngram: enzyme activity fortnsubj [lemma='akt'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: ( S21 )tQe2: trigger-arg-path: Negative_regulation >prep_for [lemma='h3k27me3'] controllert=e2: trigger-arg-path: inhibits >prep_for Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_for [lemma='h3k27me3'] controller:Gene_or_gene_productt[e2: trigger-arg-path: inhibits >prep_for [lemma='h3k27me3'] controller:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=inhibit prep_for [lemma='h3k27me3'] controllertDe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_for controllert#e1: ents2Label-mention-ngram: ( S21tXe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation prep_for controllert-e2: ents2Label-mention-ngram: enzyme activityt_e2: trigger-arg-path: inhibits prep_for [lemma='h3k27me3'] Gene_or_gene_productt+e2: args2Role-mention-ngram: ) and inhibitst*e1: ents2Label-mention-ngram: at serine 21t,e2: ents2Label-mention-ngram: ) and inhibitstke2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_for [lemma='h3k27me3'] controllertHe2: trigger-arg-path: Negative_regulation >prep_for Gene_or_gene_producttse2: trigger-arg-path: inhibits:Negative_regulation nsubj [lemma='akt'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_for [lemma='h3k27me3'] controller:Gene_or_gene_producttPe2: trigger-arg-path: inhibits >prep_for [lemma='h3k27me3'] Gene_or_gene_productt,e2: args2Role-mention-ngram: enzyme activitytztrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and [lemma='inhibit'] e2:inhibits:Negative_regulationt,e2: args2Role-mention-ngram: CONTROLLED 21 (t\e2: trigger-arg-path: inhibits:Negative_regulation >prep_for controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: ( S21t'e2: ents2Label-mention-ngram: serine 21t"e2: args2Role-mention-ngram: S21 )tee2: trigger-arg-path: lemmatizedTrigger=inhibit prep_for [lemma='h3k27me3'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED at serinet0e2: args2Role-mention-ngram: inhibits its enzymet!e2: args2Role-mention-ngram: 21 (t0e2: args2Role-mention-ngram: its enzyme activitytDe1: trigger-arg-path: phosphorylates >nsubj [lemma='akt'] controllert'e2: args2Role-mention-ngram: its enzymet#e2: ents2Label-mention-ngram: S21 )t\e2: trigger-arg-path: lemmatizedTrigger=inhibit e2: trigger-arg-path: Negative_regulation >prep_for controllertGe2: trigger-arg-path: inhibits prep_for [lemma='h3k27me3'] Gene_or_gene_producttHe2: trigger-arg-path: inhibits >prep_for controller:Gene_or_gene_productt_e2: trigger-arg-path: Negative_regulation prep_for Gene_or_gene_productt)e2: args2Role-mention-ngram: inhibits itst'e2: ents2Label-mention-ngram: at serinetbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productthtrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and e2:inhibits:Negative_regulationtWe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_for [lemma='h3k27me3'] controllertye2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='akt'] controllertYe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_for controller:Gene_or_gene_productthe2: trigger-arg-path: inhibits:Negative_regulation prep_for Gene_or_gene_productt)e2: ents2Label-mention-ngram: serine 21 (tGe2: trigger-arg-path: Negative_regulation prep_for [lemma='h3k27me3'] Gene_or_gene_producttVe2: trigger-arg-path: Negative_regulation prep_for [lemma='h3k27me3'] controllert!e1: ents2Label-mention-ngram: S21t?e2: ents2Label-mention-ngram: activity for GENE_OR_GENE_PRODUCTt'e2: ents2Label-mention-ngram: S21 ) andt4e2: args2Role-mention-ngram: activity for CONTROLLERtXe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_for controllert1e2: ents2Label-mention-ngram: enzyme activity fortme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_for controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: 21 ( S21t e1: ents2Label-mention-ngram: 21t&e2: args2Role-mention-ngram: S21 ) andt'e1: ents2Label-mention-ngram: at serinet.e1: ents2Label-mention-ngram: SHARED at serinet"e2: ents2Label-mention-ngram: 21 (t)e1: ents2Label-mention-ngram: serine 21 (t>e2: trigger-arg-path: Negative_regulation prep_for [lemma='h3k27me3'] Gene_or_gene_producttSe2: trigger-arg-path: Negative_regulation >prep_for controller:Gene_or_gene_productte1: trigger: blockstOe1: trigger-arg-path: lemmatizedTrigger=block >nsubj controller:Simple_chemicalt-e2: ents2Label-mention-ngram: and degredationt,e1: ents2Label-mention-ngram: degredation oft0e1: ents2Label-mention-ngram: and degredation oftXe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj Simple_chemicalt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='curcumin'] controller:Simple_chemicaltbe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='curcumin'] controller:Simple_chemicaltQe1: trigger-arg-path: blocks >nsubj [lemma='curcumin'] controller:Simple_chemicalt.e1: args2Role-mention-ngram: CONTROLLER blockst]trigger-to-trigger-path: e1:blocks:Negative_regulation >ccomp e2:mediated:Positive_regulationtSe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ikappak'] controllertWe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='curcumin'] Simple_chemicalt,e2: ents2Label-mention-ngram: degredation oft?e1: trigger-arg-path: lemmatizedTrigger=block >nsubj controllertMe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikappak'] controllert:e2: ents2Label-mention-ngram: mediated phosphorylation andtLe2: trigger-arg-path: mediated >nsubj [lemma='ikappak'] Gene_or_gene_producttBe1: trigger-arg-path: blocks:Negative_regulation >nsubj controllertSe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj controllertbe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikappak'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: blocks the SHAREDt'e1: args2Role-mention-ngram: blocks thet$e1: ents2Label-mention-ngram: blockst0e2: ents2Label-mention-ngram: and degredation oftotrigger-to-trigger-path: e1:blocks:Negative_regulation >ccomp [lemma='mediate'] e2:mediated:Positive_regulationt(e1: ents2Label-mention-ngram: blocks thet-e1: ents2Label-mention-ngram: and degredationt>e1: trigger-arg-path: blocks >nsubj controller:Simple_chemicalt8e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL blocks thetWe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ikappak'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='curcumin'] controllertRe1: trigger-arg-path: blocks:Negative_regulation >nsubj controller:Simple_chemicaltke2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ikappak'] controller:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='curcumin'] controllertve1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='curcumin'] controller:Simple_chemicaltDe1: trigger-arg-path: lemmatizedTrigger=block >nsubj Simple_chemicaltSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='curcumin'] Simple_chemicalt3e1: trigger-arg-path: blocks >nsubj Simple_chemicalt.e1: trigger-arg-path: blocks >nsubj controllertVe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ikappak'] controllertGe1: trigger-arg-path: blocks:Negative_regulation >nsubj Simple_chemicaltee1: trigger-arg-path: blocks:Negative_regulation >nsubj [lemma='curcumin'] controller:Simple_chemicalt)e2: ents2Label-mention-ngram: degredationt#e1: args2Role-mention-ngram: blockst3e2: ents2Label-mention-ngram: degredation of SHAREDtWshortest-path: ccomp [lemma='mediate'] >nsubj [lemma='ikappak']t3e1: ents2Label-mention-ngram: degredation of SHAREDt]e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ikappak'] Gene_or_gene_producttBe2: trigger-arg-path: mediated >nsubj [lemma='ikappak'] controllert2e1: args2Role-mention-ngram: blocks the CONTROLLEDtAe1: trigger-arg-path: blocks >nsubj [lemma='curcumin'] controllert|e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ikappak'] controller:Gene_or_gene_producttNe1: trigger-arg-path: Negative_regulation >nsubj [lemma='curcumin'] controllertke1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='curcumin'] Simple_chemicaltFe1: trigger-arg-path: blocks >nsubj [lemma='curcumin'] Simple_chemicaltWe2: trigger-arg-path: mediated >nsubj [lemma='ikappak'] controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ikappak'] controller:Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER blocks thet)e1: ents2Label-mention-ngram: degredationt:e1: ents2Label-mention-ngram: mediated phosphorylation andt=e1: ents2Label-mention-ngram: phosphorylation and degredationtce1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj controller:Simple_chemicalt=e2: ents2Label-mention-ngram: phosphorylation and degredationtZe1: trigger-arg-path: blocks:Negative_regulation >nsubj [lemma='curcumin'] Simple_chemicaltqe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ikappak'] Gene_or_gene_productt`e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ikappak'] Gene_or_gene_producttUe1: trigger-arg-path: blocks:Negative_regulation >nsubj [lemma='curcumin'] controllertge2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ikappak'] controllert4e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL blockstte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='mtor'] Gene_or_gene_producttWe2: trigger-arg-path: phosphorylate:Positive_regulation nn Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rapamycin'] theme:Simple_chemicaltde2: trigger-arg-path: phosphorylate nn [lemma='mtor'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controller:Gene_or_gene_producttce1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] Gene_or_gene_producttZe2: trigger-arg-path: phosphorylate nn [lemma='mtor'] controllert]e1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='mtor'] Gene_or_gene_productt(e2: args2Role-mention-ngram: 1 can stillt[e1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='mtor'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Simple_chemicaltUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='mtor'] controllertLe1: trigger-arg-path: bound >nsubj [lemma='rapamycin'] theme:Simple_chemicalt9e2: trigger-arg-path: phosphorylate nn controllert-e2: args2Role-mention-ngram: still CONTROLLEDtxe2: trigger-arg-path: phosphorylate:Positive_regulation nn [lemma='mtor'] Gene_or_gene_productt*e2: args2Role-mention-ngram: complex 1 cant_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rapamycin'] Simple_chemicalt]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='mtor'] themet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='mtor'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: can still CONTROLLEDtee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] themetNe1: trigger-arg-path: Binding >nsubj [lemma='rapamycin'] theme:Simple_chemicalt`e2: trigger-arg-path: Positive_regulation nn [lemma='mtor'] controllert_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controllertle1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='mtor'] Gene_or_gene_producttOshortest-path: dobj [lemma='complex'] >nn [lemma='mtor']tDe1: trigger-arg-path: bound:Binding >nsubj [lemma='rapamycin'] themetNe2: trigger-arg-path: phosphorylate nn controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn Gene_or_gene_producttje2: trigger-arg-path: Positive_regulation nn [lemma='mtor'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='mtor'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: complex 1 cantve2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='mtor'] Gene_or_gene_producttFe1: trigger-arg-path: bound >nsubj [lemma='rapamycin'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='mtor'] controller:Gene_or_gene_producttoe2: trigger-arg-path: phosphorylate nn [lemma='mtor'] controller:Gene_or_gene_producttie1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] theme:Gene_or_gene_producttbe2: trigger-arg-path: phosphorylate:Positive_regulation nn controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER complex 1t/e2: args2Role-mention-ngram: CONTROLLER complextue2: trigger-arg-path: Positive_regulation nn [lemma='mtor'] controller:Gene_or_gene_producttLe1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='mtor'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rapamycin'] Simple_chemicalt>e1: trigger-arg-path: Binding >nsubj [lemma='rapamycin'] themet4e1: trigger-arg-path: Binding >nsubj Simple_chemicalt?e2: trigger-arg-path: phosphorylate:Positive_regulation nn [lemma='mtor'] controller:Gene_or_gene_productte2: args2Role-mention-ngram: 1t1e2: ents2Label-mention-ngram: still phosphorylatetae1: trigger-arg-path: bound >dobj [lemma='complex'] >nn [lemma='mtor'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: 1 cant8e1: trigger-arg-path: bound >nsubj theme:Simple_chemicalt:e1: trigger-arg-path: Binding >nsubj theme:Simple_chemicalt5e2: ents2Label-mention-ngram: can still phosphorylatetNe1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='mtor'] themet.e2: ents2Label-mention-ngram: SHARED complex 1tce1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='mtor'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: 1 cante2: ents2Label-mention-ngram: 1tMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rapamycin'] themet@e1: trigger-arg-path: bound:Binding >nsubj theme:Simple_chemicaltKe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controllertTe1: trigger-arg-path: bound:Binding >nsubj [lemma='rapamycin'] theme:Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='mtor'] controllert&e2: args2Role-mention-ngram: complex 1t:e1: trigger-arg-path: bound:Binding >nsubj Simple_chemicaltNe1: trigger-arg-path: bound:Binding >nsubj [lemma='rapamycin'] Simple_chemicalt'e2: ents2Label-mention-ngram: complex 1t)e2: ents2Label-mention-ngram: 1 can stilltnsubj [lemma='rapamycin'] themetze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] theme:Gene_or_gene_producttMe2: trigger-arg-path: phosphorylate:Positive_regulation nn controllertKe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Simple_chemicalt?trigger-to-trigger-path: e1:bound:Binding >dobj [lemma='complex'] >rcmod [lemma='phosphorylate'] e2:phosphorylate:Positive_regulationtUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rapamycin'] themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rapamycin'] theme:Simple_chemicaltne2: trigger-arg-path: phosphorylate:Positive_regulation nn [lemma='mtor'] controllert2e1: trigger-arg-path: bound >nsubj Simple_chemicaltCe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj Simple_chemicaltHe1: trigger-arg-path: Binding >nsubj [lemma='rapamycin'] Simple_chemicaltte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: still phosphorylate SHAREDtTe1: trigger-arg-path: bound:Binding >dobj [lemma='complex'] >nn [lemma='mtor'] themetCe2: trigger-arg-path: phosphorylate nn Gene_or_gene_productt[trigger-to-trigger-path: e1:bound:Binding >dobj >rcmod e2:phosphorylate:Positive_regulationt0e1: trigger-arg-path: inhibits >ccomp controlledt>e1: trigger-arg-path: inhibits >nsubj [lemma='p27'] controllert\e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p27'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: inhibits SHARED inducedtXe1: trigger-arg-path: inhibits:Negative_regulation >ccomp controlled:Positive_regulationt9e1: trigger-arg-path: inhibits >ccomp Positive_regulationtMe1: trigger-arg-path: inhibits:Negative_regulation >ccomp Positive_regulationtUe1: trigger-arg-path: inhibits >ccomp [lemma='induce'] controlled:Positive_regulationtSe1: trigger-arg-path: inhibits >nsubj [lemma='p27'] controller:Gene_or_gene_producttRe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p27'] controllertHe1: trigger-arg-path: inhibits >nsubj [lemma='p27'] Gene_or_gene_producttJe1: trigger-arg-path: inhibits >ccomp [lemma='induce'] Positive_regulationtie1: trigger-arg-path: inhibits:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtAe1: trigger-arg-path: inhibits >ccomp [lemma='induce'] controlledt^e1: trigger-arg-path: inhibits:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtDe1: trigger-arg-path: inhibits:Negative_regulation >ccomp controlledtDe1: trigger-arg-path: inhibits >ccomp controlled:Positive_regulationtge1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p27'] controller:Gene_or_gene_producttUe1: trigger-arg-path: inhibits:Negative_regulation >ccomp [lemma='induce'] controlledtptrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='inhibit'] >dobj [lemma='binding'] e2:binding:BindingtAe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegf'] themetee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='vegf'] theme:Gene_or_gene_producttEe2: trigger-arg-path: binding >nn [lemma='vegf'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: SHARED GENE_OR_GENE_PRODUCT bindingt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bindingt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Bevacizumab'] Gene_or_gene_producttRshortest-path: dobj [lemma='binding'] >nn [lemma='vegf']tFe1: trigger-arg-path: binds:Binding >nsubj [lemma='Bevacizumab'] themet[e1: trigger-arg-path: binds:Binding >nsubj [lemma='Bevacizumab'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binding:Binding >nn [lemma='vegf'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binds >nsubj [lemma='Bevacizumab'] themet_e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='vegf'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Bevacizumab'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='vegf'] themet]e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='vegf'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='vegf'] Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegf'] Gene_or_gene_productt@e1: trigger-arg-path: Binding >nsubj [lemma='Bevacizumab'] themet6e2: trigger-arg-path: Binding >nn [lemma='vegf'] themet9e1: trigger-arg-path: binds >prep_to [lemma='vegf'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Bevacizumab'] themetVe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegf'] theme:Gene_or_gene_productt>e2: trigger-arg-path: binding:Binding >nn [lemma='vegf'] themetle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Bevacizumab'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds >nsubj [lemma='Bevacizumab'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Bevacizumab'] themetRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegf'] themetSe1: trigger-arg-path: binds >nsubj [lemma='Bevacizumab'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegf'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegf'] themetPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='vegf'] themetEe2: trigger-arg-path: Binding >nn [lemma='vegf'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='Bevacizumab'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >nsubj [lemma='Bevacizumab'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegf'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >nsubj [lemma='Bevacizumab'] theme:Gene_or_gene_productt&interceding-token ngrams: and inhibitstKe2: trigger-arg-path: Binding >nn [lemma='vegf'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='vegf'] Gene_or_gene_producttKe2: trigger-arg-path: binding >nn [lemma='vegf'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds >prep_to [lemma='vegf'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Bevacizumab'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='vegf'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: SHARED GENE_OR_GENE_PRODUCTt;e1: trigger-arg-path: Binding >prep_to [lemma='vegf'] themet6e2: trigger-arg-path: binding >nn [lemma='vegf'] themetMe2: trigger-arg-path: binding:Binding >nn [lemma='vegf'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegf'] theme:Gene_or_gene_productt*interceding-tokens-full-span: and inhibitstYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegf'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='vegf'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] themetLe2: trigger-arg-path: complex >nn [lemma='atrip'] theme:Gene_or_gene_producttinterceding-token ngrams: ; 3 )tinterceding-token ngrams: 9-1-1t/interceding-token ngrams: loaded onto RPA-ssDNAt!e1: ents2Label-mention-ngram: ; 2tfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atrip'] theme:Gene_or_gene_productt,interceding-token ngrams: interacts with thet'interceding-token ngrams: RPA-ssDNA ; 3tIe1: trigger-arg-path: binds >prep_to [lemma='rad17'] Gene_or_gene_productt(interceding-token ngrams: interacts witht$e1: args2Role-mention-ngram: ) THEMEtOe1: trigger-arg-path: binds >prep_to [lemma='rad17'] theme:Gene_or_gene_producttce1: trigger-arg-path: binds:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] Gene_or_gene_productt%interceding-token ngrams: RFC , 9-1-1t#e1: ents2Label-mention-ngram: ATRIPtle1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='complex'] >nn [lemma='atr'] Gene_or_gene_producttqtrigger-to-trigger-path: e1:binds:Binding prep_with [lemma='complex'] e2:complex:Bindingt"interceding-token ngrams: ) TOPBP1t&interceding-token ngrams: sequentiallyt4e1: ents2Label-mention-ngram: ) GENE_OR_GENE_PRODUCTtTe1: trigger-arg-path: binds:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] themet*e1: args2Role-mention-ngram: ATRIP complextLe1: trigger-arg-path: binds >nsubj [lemma='complex'] >nn [lemma='atr'] themetDe2: trigger-arg-path: Binding >nn [lemma='atr'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='complex'] >nn [lemma='atr'] themetXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atrip'] Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='atr'] Gene_or_gene_producttinterceding-token ngrams: 3t-interceding-token ngrams: sequentially loadedt+e1: ents2Label-mention-ngram: complex bindst^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atrip'] theme:Gene_or_gene_productt!e1: ents2Label-mention-ngram: 2 )t*interceding-token ngrams: are sequentiallyt?shortest-path: prep_with [lemma='complex'] >nn [lemma='atr']tKe1: trigger-arg-path: Binding >prep_to [lemma='rad17'] Gene_or_gene_productt&interceding-token ngrams: , and TOPBP1tBe1: trigger-arg-path: binds:Binding >prep_to [lemma='rad17'] themetVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atr'] Gene_or_gene_productt,e1: args2Role-mention-ngram: THEME and ATRIPt2interceding-token ngrams: sequentially loaded ontote1: ents2Label-mention-ngram: ;t!interceding-token ngrams: 9-1-1 ,t.e1: args2Role-mention-ngram: and ATRIP complext+e1: ents2Label-mention-ngram: RPA-ssDNA ; 2tQe1: trigger-arg-path: binds:Binding >prep_to [lemma='rad17'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='atr'] themet*interceding-token ngrams: onto RPA-ssDNA ;t%interceding-token ngrams: RPA-ssDNA ;t*interceding-token ngrams: TOPBP1 interactst&e1: args2Role-mention-ngram: RPA-ssDNAtinterceding-token ngrams: RFC ,t`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atrip'] Gene_or_gene_productt%interceding-token ngrams: 9-1-1 , andt)e1: args2Role-mention-ngram: to RPA-ssDNAtNe1: trigger-arg-path: Binding >nsubj [lemma='complex'] >nn [lemma='atr'] themet#interceding-token ngrams: , 9-1-1 ,tCe1: trigger-arg-path: binds:Binding >nsubj >nn Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atr'] themetAe1: trigger-arg-path: binds >nsubj >nn theme:Gene_or_gene_producttFe2: trigger-arg-path: complex >nn [lemma='atrip'] Gene_or_gene_productt+e1: args2Role-mention-ngram: to RPA-ssDNA ;t!interceding-token ngrams: , 9-1-1the1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='rad17'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='atrip'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='complex'] >nn [lemma='atr'] theme:Gene_or_gene_producttae1: trigger-arg-path: binds >nsubj [lemma='complex'] >nn [lemma='atr'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: 2 ) THEMEtde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atr'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='rad17'] Gene_or_gene_productt%interceding-token ngrams: loaded ontot\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atr'] theme:Gene_or_gene_productt#interceding-token ngrams: RPA-ssDNAtLe2: trigger-arg-path: Binding >nn [lemma='atrip'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: binds to RPA-ssDNAt/interceding-token ngrams: TOPBP1 interacts withtinterceding-token ngrams: RFCtprep_to [lemma='rad17'] themetJe2: trigger-arg-path: complex >nn [lemma='atr'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='atr'] theme:Gene_or_gene_productt,e1: trigger-arg-path: binds >nsubj >nn themet:e1: trigger-arg-path: binds >prep_to [lemma='rad17'] themetQe1: trigger-arg-path: Binding >prep_to [lemma='rad17'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atr'] Gene_or_gene_producttinterceding-token ngrams: 3 )t6e1: ents2Label-mention-ngram: 2 ) GENE_OR_GENE_PRODUCTt e1: args2Role-mention-ngram: 2 )t e1: args2Role-mention-ngram: ; 2t*e1: args2Role-mention-ngram: complex bindst(interceding-token ngrams: and TOPBP1 aret)e1: ents2Label-mention-ngram: RPA-ssDNA ;tie1: trigger-arg-path: binds:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] theme:Gene_or_gene_producttinterceding-token ngrams: ; 3t.e1: ents2Label-mention-ngram: complex binds tote1: args2Role-mention-ngram: 2te1: args2Role-mention-ngram: ;tce1: trigger-arg-path: Binding >nsubj [lemma='complex'] >nn [lemma='atr'] theme:Gene_or_gene_productt#interceding-token ngrams: and RFC ,tLtrigger-to-trigger-path: e1:binds:Binding prep_with e2:complex:Bindingt!interceding-token ngrams: and RFCt1e1: ents2Label-mention-ngram: ATRIP complex bindst[e1: trigger-arg-path: binds >nsubj [lemma='complex'] >nn [lemma='atr'] Gene_or_gene_productt"e1: args2Role-mention-ngram: ; 2 )tNe2: trigger-arg-path: complex:Binding >nn [lemma='atrip'] Gene_or_gene_productt$interceding-token ngrams: and TOPBP1t#e1: ents2Label-mention-ngram: ; 2 )t'e1: ents2Label-mention-ngram: RPA-ssDNAt interceding-token ngrams: loadedtinterceding-token ngrams: ontotTe2: trigger-arg-path: complex:Binding >nn [lemma='atrip'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='rad17'] themet+e1: ents2Label-mention-ngram: ATRIP complext?interceding-tokens-full-span: and RFC , 9-1-1 , and TOPBP1 are sequentially loaded onto RPA-ssDNA ; 3 ) TOPBP1 interacts with thet interceding-token ngrams: TOPBP1t&e1: args2Role-mention-ngram: and ATRIPtIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atrip'] themetRe2: trigger-arg-path: complex:Binding >nn [lemma='atr'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: binds to RPA-ssDNAt/e1: ents2Label-mention-ngram: and ATRIP complext-shortest-path: prep_with >nnt*e1: args2Role-mention-ngram: RPA-ssDNA ; 2tte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='atr'] Gene_or_gene_productt;e1: trigger-arg-path: binds >nsubj >nn Gene_or_gene_productt$interceding-token ngrams: 3 ) TOPBP1t,interceding-token ngrams: ) TOPBP1 interactst$interceding-token ngrams: TOPBP1 aretGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atr'] themetQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atrip'] themet7e2: trigger-arg-path: Binding >nn [lemma='atrip'] themet,e1: ents2Label-mention-ngram: to RPA-ssDNA ;t5e2: trigger-arg-path: Binding >nn [lemma='atr'] themet1interceding-token ngrams: are sequentially loadedt'e1: ents2Label-mention-ngram: and ATRIPt.e1: ents2Label-mention-ngram: SHARED and ATRIPt*e1: ents2Label-mention-ngram: to RPA-ssDNAt7e2: trigger-arg-path: complex >nn [lemma='atrip'] themet-e1: args2Role-mention-ngram: complex binds tot5e2: trigger-arg-path: complex >nn [lemma='atr'] themet(e1: args2Role-mention-ngram: RPA-ssDNA ;t]e1: trigger-arg-path: Binding >nsubj [lemma='complex'] >nn [lemma='atr'] Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='rad17'] themetZe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='rad17'] Gene_or_gene_productt0e1: args2Role-mention-ngram: ATRIP complex bindst?e2: trigger-arg-path: complex:Binding >nn [lemma='atrip'] themet(interceding-token ngrams: onto RPA-ssDNAt"e1: args2Role-mention-ngram: ATRIPt4e1: trigger-arg-path: binds:Binding >nsubj >nn themetIe1: trigger-arg-path: binds:Binding >nsubj >nn theme:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='complex'] >nn [lemma='atr'] theme:Gene_or_gene_producttWe1: trigger-arg-path: binds:Binding >prep_to [lemma='rad17'] theme:Gene_or_gene_productt#interceding-token ngrams: interactst`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='rad17'] theme:Gene_or_gene_productt1interceding-token ngrams: TOPBP1 are sequentiallytWe2: trigger-arg-path: binding:Binding nn [lemma='ra'] Familyt+e2: trigger-arg-path: binding nn themetYe2: trigger-arg-path: binding:Binding nn [lemma='cdc25'] themet,e2: trigger-arg-path: Binding nn Familyt:e2: trigger-arg-path: binding:Binding nn theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=binding nn Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='ra'] themetHe2: trigger-arg-path: binding:Binding nn theme:Gene_or_gene_producttBe2: trigger-arg-path: binding:Binding nn Gene_or_gene_producttfe2: trigger-arg-path: binding nn [lemma='cdc25'] theme:Gene_or_gene_productt4e2: trigger-arg-path: binding:Binding nn Familyt,e2: trigger-arg-path: binding nn FamilytZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:complex:Binding nsubj [lemma='perturbation'] >prep_of [lemma='interaction'] >nn [lemma='binding'] e2:binding:Bindingthe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] themet>e2: trigger-arg-path: lemmatizedTrigger=binding nn Familyt`e2: trigger-arg-path: binding nn [lemma='cdc25'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='ra'] theme:Familyt`e2: trigger-arg-path: Binding nn [lemma='cdc25'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] themetNe2: trigger-arg-path: binding nn [lemma='ra'] themetOe2: trigger-arg-path: Binding nn [lemma='ra'] FamilytLe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn theme:FamilytQe2: trigger-arg-path: binding nn [lemma='cdc25'] themetqtrigger-to-trigger-path: e1:complex:Binding nsubj >prep_of >nn e2:binding:BindingtRe2: trigger-arg-path: lemmatizedTrigger=binding nn theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] Familytxe2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] theme:Gene_or_gene_productt:e2: trigger-arg-path: binding nn Gene_or_gene_producttne2: trigger-arg-path: binding:Binding nn [lemma='cdc25'] theme:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn Familythe2: trigger-arg-path: binding:Binding nn [lemma='cdc25'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='ra'] Familytre2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='cdc25'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] themetOe2: trigger-arg-path: binding nn [lemma='ra'] Familytoe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='ra'] theme:Familyt=e2: trigger-arg-path: lemmatizedTrigger=binding nn themet2e2: trigger-arg-path: binding nn theme:FamilytDe2: trigger-arg-path: lemmatizedTrigger=binding nn theme:Familyt@e2: trigger-arg-path: binding nn theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding nn [lemma='ra'] themetVe2: trigger-arg-path: binding:Binding nn [lemma='ra'] themetQe2: trigger-arg-path: Binding nn [lemma='cdc25'] themet3e2: trigger-arg-path: binding:Binding nn themet2e2: trigger-arg-path: Binding nn theme:Familytze2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='cdc25'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn Gene_or_gene_producttUe2: trigger-arg-path: Binding nn [lemma='ra'] theme:Familyt]e2: trigger-arg-path: binding:Binding nn [lemma='ra'] theme:FamilytUe2: trigger-arg-path: binding nn [lemma='ra'] theme:Familytfe2: trigger-arg-path: Binding nn [lemma='cdc25'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] Gene_or_gene_productt]e2: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: 1 by SHAREDtfe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: of SHARED 1tde1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: CONTROLLED 1tHe2: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] controllertne1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controllert,e1: args2Role-mention-ngram: CONTROLLED 1 bytae2: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: 1 byt,e2: args2Role-mention-ngram: CONTROLLED 1 byt)e1: ents2Label-mention-ngram: 1 by SHAREDtZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] controllert,e1: args2Role-mention-ngram: 1 by CONTROLLERt!e2: args2Role-mention-ngram: 1 byt&e1: ents2Label-mention-ngram: SHARED 1t&e2: ents2Label-mention-ngram: SHARED 1tHe1: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] controllertxe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_productt\e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controllert)e1: ents2Label-mention-ngram: of SHARED 1tRe2: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] Gene_or_gene_productt\e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controllert,e2: args2Role-mention-ngram: 1 by CONTROLLERtLe2: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] controllert)e2: ents2Label-mention-ngram: SHARED 1 bytVe1: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: 1 bytoe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controllerte1: ents2Label-mention-ngram: 1tZe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] controllertqe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_producttVe2: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_producttLe1: trigger-arg-path: Positive_regulation >prep_by [lemma='ulk1'] controllertoe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='ulk1'] controller:Gene_or_gene_producttfe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: SHARED 1 byt]e1: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] controller:Gene_or_gene_producttRe1: trigger-arg-path: phosphorylation >prep_by [lemma='ulk1'] Gene_or_gene_producttqe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='ulk1'] controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: 1 byt)e2: args2Role-mention-ngram: CONTROLLED 1te1: args2Role-mention-ngram: 1t'e2: ents2Label-mention-ngram: and ATG12t,e2: args2Role-mention-ngram: THEME and ATG12tPe2: trigger-arg-path: interacts >prep_with [lemma='atg16l'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: complex interactstQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg12'] themet9e2: trigger-arg-path: Binding >nsubj [lemma='atg5'] themet7e1: trigger-arg-path: Binding >nn [lemma='atg12'] themetie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='atg5'] theme:Gene_or_gene_producttKe1: trigger-arg-path: complex nn [lemma='atg12'] themetXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atg12'] Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_with [lemma='atg16l'] themetCe2: trigger-arg-path: interacts:Binding >nsubj [lemma='atg5'] themetAe2: trigger-arg-path: interacts >prep_with [lemma='atg16l'] themet&e2: args2Role-mention-ngram: and ATG12tGtrigger-to-trigger-path: e1:complex:Binding nn [lemma='atg12'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg12'] theme:Gene_or_gene_productt;e2: trigger-arg-path: interacts >nsubj [lemma='atg5'] themetDe1: trigger-arg-path: complex:Binding nn [lemma='atg12'] themetRe2: trigger-arg-path: interacts:Binding >nsubj [lemma='atg5'] Gene_or_gene_producttPe2: trigger-arg-path: interacts >nsubj [lemma='atg5'] theme:Gene_or_gene_producttJe2: trigger-arg-path: interacts >nsubj [lemma='atg5'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atg16l'] themet[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='atg5'] Gene_or_gene_producttKe1: trigger-arg-path: Binding nn [lemma='atg12'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Binding >nsubj [lemma='atg5'] Gene_or_gene_producttQe1: trigger-arg-path: Binding prep_with [lemma='atg16l'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_with [lemma='atg16l'] Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_with [lemma='atg16l'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='atg5'] themet]e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='atg12'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts >prep_with [lemma='atg16l'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: ATG12t^e2: trigger-arg-path: interacts:Binding >prep_with [lemma='atg16l'] theme:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg16l'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: ATG12 complext#e2: ents2Label-mention-ngram: ATG12tZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg16l'] themetLe1: trigger-arg-path: Binding >nn [lemma='atg12'] theme:Gene_or_gene_producttSe1: trigger-arg-path: complex:Binding prep_with [lemma='atg16l'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: and ATG12 complext?e1: trigger-arg-path: complex:Binding >nn [lemma='atg12'] themetce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='atg5'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg12'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='atg5'] theme:Gene_or_gene_producttYe1: trigger-arg-path: complex:Binding prep_with [lemma='atg16l'] theme:Gene_or_gene_producttTe1: trigger-arg-path: complex:Binding >nn [lemma='atg12'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: complex interacts witht4e2: args2Role-mention-ngram: ATG12 complex interactstVe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='atg12'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg16l'] Gene_or_gene_productt.e2: args2Role-mention-ngram: complex interactstFe1: trigger-arg-path: Binding >nn [lemma='atg12'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED and ATG12tZtrigger-to-trigger-path: e1:complex:Binding prep_with [lemma='atg16l'] themetXe2: trigger-arg-path: interacts:Binding >nsubj [lemma='atg5'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='atg5'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='atg5'] themetOe1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] themetUe1: trigger-arg-path: binds:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sirt2'] theme:Gene_or_gene_producttNe2: trigger-arg-path: complex:Binding >nn [lemma='sirt2'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='sirt2'] Gene_or_gene_productt;e1: trigger-arg-path: binds >nsubj [lemma='tubulin'] Familyt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hdac6'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sirt2'] themet=e1: trigger-arg-path: Binding >nsubj [lemma='tubulin'] FamilytTtrigger-to-trigger-path: e1:binds:Binding >dobj [lemma='complex'] e2:complex:Bindingtnsubj [lemma='tubulin'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tubulin'] FamilytXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hdac6'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='sirt2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binds:Binding >dobj >nn theme:Gene_or_gene_productt:e1: trigger-arg-path: binds >nsubj [lemma='tubulin'] themetBtrigger-to-trigger-path: e1:binds:Binding >dobj e2:complex:BindingtIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sirt2'] themetLe2: trigger-arg-path: Binding >nn [lemma='hdac6'] theme:Gene_or_gene_producttde1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tubulin'] themetIe1: trigger-arg-path: binds:Binding >nsubj [lemma='tubulin'] theme:Familyt7e2: trigger-arg-path: Binding >nn [lemma='sirt2'] themet7e2: trigger-arg-path: complex >nn [lemma='sirt2'] themetCe1: trigger-arg-path: Binding >nsubj [lemma='tubulin'] theme:Familyt`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hdac6'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: FAMILY binds andt?e2: trigger-arg-path: complex:Binding >nn [lemma='sirt2'] themetbe1: trigger-arg-path: binds >dobj [lemma='complex'] >nn [lemma='sirt2'] theme:Gene_or_gene_producttFe2: trigger-arg-path: complex >nn [lemma='hdac6'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tubulin'] theme:Familytue1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] Gene_or_gene_productt/e1: args2Role-mention-ngram: binds and inhibitstTe2: trigger-arg-path: complex:Binding >nn [lemma='sirt2'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='tubulin'] themetTe2: trigger-arg-path: complex:Binding >nn [lemma='hdac6'] theme:Gene_or_gene_producttBe1: trigger-arg-path: binds:Binding >dobj >nn Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='sirt2'] Gene_or_gene_producttje1: trigger-arg-path: binds:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='sirt2'] theme:Gene_or_gene_productt^e1: trigger-arg-path: Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] themetme1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='sirt2'] Gene_or_gene_productt\e1: trigger-arg-path: binds >dobj [lemma='complex'] >nn [lemma='sirt2'] Gene_or_gene_productt@e1: trigger-arg-path: binds >dobj >nn theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: binds and inhibitstFe2: trigger-arg-path: Binding >nn [lemma='hdac6'] Gene_or_gene_productt:e1: trigger-arg-path: binds >dobj >nn Gene_or_gene_producttde1: trigger-arg-path: binds:Binding >dobj [lemma='complex'] >nn [lemma='sirt2'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sirt2'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: FAMILY bindstNe2: trigger-arg-path: complex:Binding >nn [lemma='hdac6'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hdac6'] themetfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hdac6'] theme:Gene_or_gene_producttAe1: trigger-arg-path: binds >nsubj [lemma='tubulin'] theme:Familyt^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='complex'] >nn [lemma='sirt2'] themet`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='sirt2'] Gene_or_gene_productt/e1: args2Role-mention-ngram: inhibits the THEMEtIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hdac6'] themetFe2: trigger-arg-path: complex >nn [lemma='sirt2'] Gene_or_gene_producttPshortest-path: dobj [lemma='complex'] >nn [lemma='sirt2']tBe1: trigger-arg-path: binds:Binding >nsubj [lemma='tubulin'] themetCe1: trigger-arg-path: binds:Binding >nsubj [lemma='tubulin'] FamilytMe1: trigger-arg-path: binds >dobj [lemma='complex'] >nn [lemma='sirt2'] themetLe2: trigger-arg-path: complex >nn [lemma='sirt2'] theme:Gene_or_gene_productt7e2: trigger-arg-path: Binding >nn [lemma='hdac6'] themet-e1: args2Role-mention-ngram: and inhibits thetLe2: trigger-arg-path: complex >nn [lemma='hdac6'] theme:Gene_or_gene_productt7e2: trigger-arg-path: complex >nn [lemma='hdac6'] themet?e2: trigger-arg-path: complex:Binding >nn [lemma='hdac6'] themetZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tubulin'] theme:FamilytTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='tubulin'] Familyt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='beclin'] controller:Gene_or_gene_producttVe1: trigger-arg-path: Negative_regulation >nsubj [lemma='beclin'] Gene_or_gene_productt-e1: args2Role-mention-ngram: tumorigenesis byt6e1: ents2Label-mention-ngram: tumorigenesis by formingt*e1: ents2Label-mention-ngram: a SHARED andt2e2: args2Role-mention-ngram: CONTROLLED , mediatedt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='beclin'] Negative_regulationt(e1: ents2Label-mention-ngram: regulatorst%e1: ents2Label-mention-ngram: formingt$e1: args2Role-mention-ngram: formingt1e2: ents2Label-mention-ngram: regulators , SHAREDt)e1: args2Role-mention-ngram: by forming at*e2: ents2Label-mention-ngram: a SHARED andtze2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='uvrag'] controller:Gene_or_gene_producttne2: trigger-arg-path: mediated:Positive_regulation nsubj controlled:Negative_regulationtUe2: trigger-arg-path: Positive_regulation >agent [lemma='uvrag'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED 1 cant&e1: args2Role-mention-ngram: forming atie2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='uvrag'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: its positive regulatorst)e1: ents2Label-mention-ngram: and inhibittJe1: trigger-arg-path: inhibit >nsubj [lemma='beclin'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: positive regulatorstke2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj controlledt?trigger-to-trigger-path: e1:inhibit:Negative_regulation >prepc_by [lemma='form'] >dobj [lemma='pi3kiius'] >vmod [lemma='mediate'] e2:mediated:Positive_regulationt'e2: ents2Label-mention-ngram: forming at6e2: ents2Label-mention-ngram: tumorigenesis by formingt%e2: ents2Label-mention-ngram: inhibittZe2: trigger-arg-path: mediated nsubj controlled:Negative_regulationtFe2: trigger-arg-path: mediated nsubj controlledt'e2: args2Role-mention-ngram: , mediatedt*e1: args2Role-mention-ngram: 1 can enhancet7e2: ents2Label-mention-ngram: and inhibit tumorigenesist/e1: ents2Label-mention-ngram: enhance autophagyt*e2: ents2Label-mention-ngram: SHARED 1 cant5e1: args2Role-mention-ngram: tumorigenesis by formingt+e1: ents2Label-mention-ngram: autophagy andt2e1: args2Role-mention-ngram: autophagy and inhibitt?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='beclin'] controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='beclin'] controlled:Negative_regulationtfe2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='uvrag'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: autophagy and inhibittKe2: trigger-arg-path: Positive_regulation >agent [lemma='uvrag'] controllert?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='beclin'] controlled:Negative_regulationtUe2: trigger-arg-path: mediated >agent [lemma='uvrag'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: autophagyt-e2: ents2Label-mention-ngram: by its positivet.e1: ents2Label-mention-ngram: forming a SHAREDt3e1: ents2Label-mention-ngram: autophagy and inhibitt-e2: ents2Label-mention-ngram: mediated by itst*e1: ents2Label-mention-ngram: its positivetQe2: trigger-arg-path: Positive_regulation nsubj controlledt0e1: ents2Label-mention-ngram: complex , mediatedt&e1: args2Role-mention-ngram: autophagyt3e1: ents2Label-mention-ngram: positive regulators ,t)e1: ents2Label-mention-ngram: can enhancet(e2: ents2Label-mention-ngram: , mediatedt*e1: ents2Label-mention-ngram: regulators ,tTe1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='beclin'] controllert*e2: ents2Label-mention-ngram: its positivetUe1: trigger-arg-path: inhibit >nsubj [lemma='beclin'] controller:Gene_or_gene_producttJe2: trigger-arg-path: mediated >agent [lemma='uvrag'] Gene_or_gene_productt*e1: args2Role-mention-ngram: tumorigenesistQe2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='uvrag'] controllert(e1: args2Role-mention-ngram: and inhibitt,e2: args2Role-mention-ngram: mediated by itst*e1: ents2Label-mention-ngram: by forming at7e1: ents2Label-mention-ngram: and inhibit tumorigenesist,e2: args2Role-mention-ngram: by its positivet*e2: ents2Label-mention-ngram: regulators ,t:shortest-path: aux [lemma='can']t0e2: args2Role-mention-ngram: positive regulatorst.e2: ents2Label-mention-ngram: SHARED complex ,t'e1: ents2Label-mention-ngram: forming at+e2: ents2Label-mention-ngram: 1 can enhancet*e2: args2Role-mention-ngram: , mediated byt3e2: ents2Label-mention-ngram: positive regulators ,t?e2: trigger-arg-path: mediated nsubj [lemma='beclin'] controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='beclin'] Negative_regulationt*e2: ents2Label-mention-ngram: by forming at`e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj Negative_regulationte2: CONTROLLED: 4t%e2: ents2Label-mention-ngram: enhancet^e1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='beclin'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: complex , mediatedtee2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='uvrag'] controllert(e2: ents2Label-mention-ngram: by formingt(e1: args2Role-mention-ngram: can enhancet)e1: args2Role-mention-ngram: CONTROLLER 1t.e2: ents2Label-mention-ngram: tumorigenesis bytee2: trigger-arg-path: Positive_regulation nsubj controlled:Negative_regulationt3e1: ents2Label-mention-ngram: enhance autophagy andt-e1: ents2Label-mention-ngram: by its positivet)e2: args2Role-mention-ngram: , CONTROLLERt?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='beclin'] Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='beclin'] controlledt&e1: ents2Label-mention-ngram: , SHAREDt-e1: ents2Label-mention-ngram: mediated by itst`e2: trigger-arg-path: Positive_regulation >agent [lemma='uvrag'] controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj controlledt'e2: ents2Label-mention-ngram: complex ,tZe2: trigger-arg-path: Positive_regulation nsubj Negative_regulationt%e1: ents2Label-mention-ngram: enhancet$e1: args2Role-mention-ngram: enhancet&e2: ents2Label-mention-ngram: , SHAREDt(e1: ents2Label-mention-ngram: , mediatedt'e1: ents2Label-mention-ngram: autophagyt\e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='beclin'] Gene_or_gene_productt*e1: args2Role-mention-ngram: autophagy andt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='beclin'] controlledt+e2: ents2Label-mention-ngram: tumorigenesist?e2: trigger-arg-path: mediated nsubj [lemma='beclin'] Negative_regulationtae1: trigger-arg-path: Negative_regulation >nsubj [lemma='beclin'] controller:Gene_or_gene_productt6e1: args2Role-mention-ngram: and inhibit tumorigenesistpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='beclin'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: , mediated byt4e2: args2Role-mention-ngram: its positive regulatorst%e2: args2Role-mention-ngram: positivet#e1: ents2Label-mention-ngram: 1 cantLe1: trigger-arg-path: Negative_regulation >nsubj [lemma='beclin'] controllert@e2: trigger-arg-path: mediated >agent [lemma='uvrag'] controllert/e2: ents2Label-mention-ngram: enhance autophagytZe2: trigger-arg-path: mediated:Positive_regulation nsubj controlledt2e1: args2Role-mention-ngram: enhance autophagy andt$e1: ents2Label-mention-ngram: by itst"e1: args2Role-mention-ngram: 1 cant4e2: args2Role-mention-ngram: regulators , CONTROLLERt6e1: ents2Label-mention-ngram: inhibit tumorigenesis byt[e2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='uvrag'] Gene_or_gene_productt)e2: args2Role-mention-ngram: its positivet?e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='beclin'] controlledtce2: trigger-arg-path: mediated:Positive_regulation nsubj Negative_regulationt3e2: ents2Label-mention-ngram: enhance autophagy andtRe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='beclin'] controllert+e1: ents2Label-mention-ngram: 1 can enhancetoe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='uvrag'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: its positive regulatorst)e1: args2Role-mention-ngram: a CONTROLLEDt.e1: args2Role-mention-ngram: enhance autophagytOe2: trigger-arg-path: mediated nsubj Negative_regulationtge1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='beclin'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: tumorigenesis bytke2: trigger-arg-path: lemmatizedTrigger=mediate nsubj controlled:Negative_regulationt.e2: ents2Label-mention-ngram: forming a SHAREDt(e2: ents2Label-mention-ngram: regulatorst1e1: ents2Label-mention-ngram: regulators , SHAREDt)e2: args2Role-mention-ngram: regulators ,t5e1: args2Role-mention-ngram: inhibit tumorigenesis byt?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='beclin'] controlledt)e2: ents2Label-mention-ngram: and inhibitt@e1: trigger-arg-path: inhibit >nsubj [lemma='beclin'] controllertfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='beclin'] controllert&e1: ents2Label-mention-ngram: positivet-e1: args2Role-mention-ngram: CONTROLLER 1 cant'e2: args2Role-mention-ngram: regulatorst&e2: ents2Label-mention-ngram: positivet'e1: ents2Label-mention-ngram: complex ,te2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj controlled:Negative_regulationt+e2: ents2Label-mention-ngram: autophagy andt.e1: ents2Label-mention-ngram: SHARED complex ,t1e1: ents2Label-mention-ngram: positive regulatorst2e2: args2Role-mention-ngram: positive regulators ,t'e1: args2Role-mention-ngram: by formingt1e1: args2Role-mention-ngram: forming a CONTROLLEDt$e2: ents2Label-mention-ngram: by itstte2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj Negative_regulationt6e2: ents2Label-mention-ngram: inhibit tumorigenesis byt^e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='uvrag'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: by formingt%e2: ents2Label-mention-ngram: formingt2e1: args2Role-mention-ngram: inhibit tumorigenesist+e1: ents2Label-mention-ngram: , mediated byt+e1: ents2Label-mention-ngram: tumorigenesist2e1: args2Role-mention-ngram: can enhance autophagyt?e2: trigger-arg-path: mediated nsubj [lemma='beclin'] controlledt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='beclin'] controlled:Negative_regulationt#e2: args2Role-mention-ngram: by itstmtrigger-to-trigger-path: e1:inhibit:Negative_regulation >prepc_by >dobj >vmod e2:mediated:Positive_regulationt&e1: ents2Label-mention-ngram: a SHAREDt3e2: ents2Label-mention-ngram: can enhance autophagyt&e2: ents2Label-mention-ngram: a SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='beclin'] Negative_regulationtTe2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='uvrag'] controllert3e2: ents2Label-mention-ngram: inhibit tumorigenesist3e1: ents2Label-mention-ngram: can enhance autophagyt3e1: ents2Label-mention-ngram: inhibit tumorigenesistie1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='beclin'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: can enhancet'e1: args2Role-mention-ngram: downstreamt+e2: ents2Label-mention-ngram: also interactt>e2: trigger-arg-path: interact >prep_with [lemma='tsc2'] themet*e1: ents2Label-mention-ngram: a downstreamt1e1: ents2Label-mention-ngram: a downstream targett%e2: args2Role-mention-ngram: can alsot`e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='gsk-3'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='gsk-3'] Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='tsc2'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tsc2'] Gene_or_gene_productt1e1: args2Role-mention-ngram: downstream target oft/e2: ents2Label-mention-ngram: can also interactt0e2: ents2Label-mention-ngram: also interact witht/e2: args2Role-mention-ngram: also interact withthe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='gsk-3'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: downstream targett_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc2'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: is a downstreamt+e2: args2Role-mention-ngram: THEME can alsotSe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='gsk-3'] themet&e2: ents2Label-mention-ngram: can alsot=e2: trigger-arg-path: Binding >prep_with [lemma='tsc2'] themetPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc2'] themetHe1: trigger-arg-path: target >nsubj [lemma='gsk-3'] Gene_or_gene_producttVe1: trigger-arg-path: target:Binding >nsubj [lemma='gsk-3'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tsc2'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: a downstream targettTshortest-path: nsubj [lemma='it']tXtrigger-to-trigger-path: e1:target:Binding prep_with [lemma='tsc2'] themetZe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='gsk-3'] Gene_or_gene_producttAe1: trigger-arg-path: target:Binding >nsubj [lemma='gsk-3'] themet#shortest-path: nsubjt/e1: ents2Label-mention-ngram: downstream targett)e1: args2Role-mention-ngram: a downstreamtSe2: trigger-arg-path: interact >prep_with [lemma='tsc2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc2'] theme:Gene_or_gene_producttUe2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc2'] Gene_or_gene_producttNe1: trigger-arg-path: target >nsubj [lemma='gsk-3'] theme:Gene_or_gene_producttPe1: trigger-arg-path: target:Binding >nsubj [lemma='gsk-3'] Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='gsk-3'] themetFe2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc2'] themetEtrigger-to-trigger-path: e1:target:Binding prep_with [lemma='tsc2'] Gene_or_gene_productt,e1: args2Role-mention-ngram: is a downstreamt[e2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc2'] theme:Gene_or_gene_producttinterceding-tokens-full-span: ,tMe2: trigger-arg-path: interact >prep_with [lemma='tsc2'] Gene_or_gene_productt*e2: args2Role-mention-ngram: also interactt-e2: ents2Label-mention-ngram: SHARED can alsot(e1: ents2Label-mention-ngram: downstreamt.e2: args2Role-mention-ngram: can also interactt9e1: trigger-arg-path: target >nsubj [lemma='gsk-3'] themet2e1: ents2Label-mention-ngram: downstream target oft?interceding-tokens-full-span: reveals that , despite its role as a tumor suppressor , NF-kappaB becomes activated after reactivation of p53 even when thet[e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp >nsubj BioProcesst*interceding-token ngrams: despite its roletinterceding-token ngrams: rolet?shortest-path: ccomp [lemma='become'] >acomp [lemma='activate'] >advcl [lemma='induce'] >nsubj [lemma='p53']tJe2: trigger-arg-path: induced:Positive_activation >ccomp >nsubj BioProcesst,interceding-token ngrams: after reactivationthe2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] BioProcesst%interceding-token ngrams: , NF-kappaBtjtrigger-to-trigger-path: e1:interaction:Binding ccomp >acomp >advcl e2:induced:Positive_activationt(interceding-token ngrams: that , despitetKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] themetre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nf-kappab'] Gene_or_gene_productt'interceding-token ngrams: , despite itst"interceding-token ngrams: its rolet?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlled:BioProcesstIe1: trigger-arg-path: interaction >prep_between [lemma='nf-kappab'] themetfe1: trigger-arg-path: interaction:Binding >prep_between [lemma='nf-kappab'] theme:Gene_or_gene_productt`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='nf-kappab'] Gene_or_gene_producttBe2: trigger-arg-path: Positive_activation >ccomp >nsubj BioProcesst"interceding-token ngrams: p53 eventpe2: trigger-arg-path: induced:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] BioProcesst)interceding-token ngrams: reactivation oftTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controllert%interceding-token ngrams: its role ast[e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='p53'] Gene_or_gene_producttMe2: trigger-arg-path: Positive_activation >ccomp >nsubj controlled:BioProcesstRe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubj controlled:BioProcesst*interceding-token ngrams: tumor suppressortXe1: trigger-arg-path: interaction >prep_between [lemma='nf-kappab'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nf-kappab'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] Gene_or_gene_producttZe1: trigger-arg-path: Binding >prep_between [lemma='nf-kappab'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] BioProcesst#interceding-token ngrams: even whent^e1: trigger-arg-path: interaction >prep_between [lemma='nf-kappab'] theme:Gene_or_gene_producttUe2: trigger-arg-path: induced:Positive_activation >ccomp >nsubj controlled:BioProcesstRe1: trigger-arg-path: interaction >prep_between [lemma='p53'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp >nsubj controlledtCe1: trigger-arg-path: interaction >prep_between [lemma='p53'] themet\e2: trigger-arg-path: induced >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlledt&interceding-token ngrams: suppressor ,t=e2: trigger-arg-path: induced >nsubj [lemma='p53'] controllertTe1: trigger-arg-path: Binding >prep_between [lemma='nf-kappab'] Gene_or_gene_producttge2: trigger-arg-path: induced >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlled:BioProcesst1interceding-token ngrams: becomes activated aftert'interceding-token ngrams: p53 even whentse2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlled:BioProcesstNe1: trigger-arg-path: Binding >prep_between [lemma='p53'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubj BioProcesstNe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='p53'] controllertinterceding-token ngrams: as at1shortest-path: ccomp >acomp >advcl >nsubjtwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='p53'] controller:Gene_or_gene_productt$interceding-token ngrams: as a tumort!interceding-token ngrams: despitet+interceding-token ngrams: becomes activatedt#interceding-token ngrams: NF-kappaBtfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp >nsubj controlled:BioProcesstIe2: trigger-arg-path: Positive_activation >nsubj [lemma='p53'] controllert6e2: trigger-arg-path: induced >ccomp >nsubj BioProcesstAe2: trigger-arg-path: induced >ccomp >nsubj controlled:BioProcesst%interceding-token ngrams: of p53 eventhe2: trigger-arg-path: Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlledtXe2: trigger-arg-path: induced:Positive_activation >nsubj controller:Gene_or_gene_producttJe2: trigger-arg-path: induced:Positive_activation >ccomp >nsubj controlledt?e1: trigger-arg-path: Binding >prep_between [lemma='p53'] themet)interceding-token ngrams: activated aftert5interceding-token ngrams: NF-kappaB becomes activatedt]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] themet#interceding-token ngrams: , despitet!interceding-token ngrams: a tumort7e2: ents2Label-mention-ngram: SHARED induced BIOPROCESSt6interceding-token ngrams: activated after reactivationtme2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] BioProcesst+interceding-token ngrams: NF-kappaB becomest[e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nf-kappab'] themet$interceding-token ngrams: suppressort!interceding-token ngrams: revealstpe2: trigger-arg-path: induced:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlledtfe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='p53'] controller:Gene_or_gene_producttEe1: trigger-arg-path: Binding >prep_between [lemma='nf-kappab'] themet&interceding-token ngrams: reactivationt/interceding-token ngrams: after reactivation oftBe2: trigger-arg-path: Positive_activation >ccomp >nsubj controlledtre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] theme:Gene_or_gene_productt,interceding-token ngrams: a tumor suppressortTe1: trigger-arg-path: Binding >prep_between [lemma='p53'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nf-kappab'] themet0interceding-token ngrams: suppressor , NF-kappaBt#interceding-token ngrams: role as atde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlled:BioProcesstRe2: trigger-arg-path: induced >nsubj [lemma='p53'] controller:Gene_or_gene_producttQe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='p53'] controllert`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] theme:Gene_or_gene_productt{e2: trigger-arg-path: induced:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlled:BioProcesstxe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nf-kappab'] theme:Gene_or_gene_producttZe1: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] Gene_or_gene_productt,interceding-token ngrams: tumor suppressor ,t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlledtXe1: trigger-arg-path: interaction >prep_between [lemma='p53'] theme:Gene_or_gene_productt%interceding-token ngrams: despite itstUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] themetSe2: trigger-arg-path: Positive_activation >nsubj [lemma='p53'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: even when thetce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='p53'] controller:Gene_or_gene_producttGe2: trigger-arg-path: induced >nsubj [lemma='p53'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nf-kappab'] Gene_or_gene_productt"interceding-token ngrams: when thet!interceding-token ngrams: role astGe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubj controlledt^e2: trigger-arg-path: Positive_activation >nsubj [lemma='p53'] controller:Gene_or_gene_productt\e2: trigger-arg-path: induced >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] BioProcesstCe2: trigger-arg-path: induced:Positive_activation >nsubj controllert interceding-token ngrams: of p53t!interceding-token ngrams: becomest6e2: trigger-arg-path: induced >ccomp >nsubj controlledtie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:interaction:Binding ccomp [lemma='become'] >acomp [lemma='activate'] >advcl [lemma='induce'] e2:induced:Positive_activationtinterceding-token ngrams: tumortMe2: trigger-arg-path: induced:Positive_activation >nsubj Gene_or_gene_productt-interceding-token ngrams: , NF-kappaB becomest0e2: ents2Label-mention-ngram: induced BIOPROCESSt&interceding-token ngrams: reveals thattXe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='p53'] Gene_or_gene_productt-interceding-token ngrams: reactivation of p53t(interceding-token ngrams: reveals that ,tQe1: trigger-arg-path: interaction:Binding >prep_between [lemma='nf-kappab'] themet interceding-token ngrams: that ,tme2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='require'] >nsubj [lemma='apoptosis'] controlledtbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='p53'] controllertVe1: trigger-arg-path: disrupts:Negative_activation >dobj [lemma='beclin-1'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=complex nsubj controllert$interceding-token ngrams: does not ,tCe1: trigger-arg-path: disrupts:Negative_activation >dobj controlledt$interceding-token ngrams: Beclin-1 /t`e1: trigger-arg-path: disrupts:Negative_activation >dobj [lemma='beclin-1'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vbcl'] themetEe2: trigger-arg-path: Binding >nn [lemma='vbcl'] Gene_or_gene_productt(interceding-token ngrams: order Beclin-1t_e1: trigger-arg-path: disrupts:Negative_activation >nsubj [lemma='cbcl-2'] Gene_or_gene_producttinterceding-token ngrams: formstRe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='cbcl-2'] controllertDe1: trigger-arg-path: disrupts >dobj controlled:Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT disruptst*e1: ents2Label-mention-ngram: disrupts thet interceding-token ngrams: vBcl-2tSe1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj [lemma='beclin-1'] controlledt{e1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >nsubj [lemma='cbcl-2'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: disruptst(interceding-token ngrams: whereas vBcl-2t)interceding-token ngrams: / UVRAG complext&e1: ents2Label-mention-ngram: disruptstfe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >nsubj [lemma='cbcl-2'] controllertYe1: trigger-arg-path: disrupts:Negative_activation >nsubj controller:Gene_or_gene_producttKe1: trigger-arg-path: disrupts >nsubj [lemma='cbcl-2'] Gene_or_gene_productt!interceding-token ngrams: insteadt*interceding-token ngrams: , whereas vBcl-2t?e1: ents2Label-mention-ngram: disrupts the GENE_OR_GENE_PRODUCTtDe1: trigger-arg-path: Negative_activation >dobj Gene_or_gene_productt"interceding-token ngrams: Beclin-1t/e1: trigger-arg-path: disrupts >dobj controlledtLe2: trigger-arg-path: Binding nsubj [lemma='cbcl-2'] controller:Gene_or_gene_producttbe1: trigger-arg-path: Negative_activation >dobj [lemma='beclin-1'] controlled:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj controller:Gene_or_gene_producttinterceding-token ngrams: not ,t>e2: trigger-arg-path: complex:Binding >nn [lemma='vbcl'] themetKe2: trigger-arg-path: Binding >nn [lemma='vbcl'] theme:Gene_or_gene_productt*interceding-token ngrams: order Beclin-1 /t6e2: trigger-arg-path: Binding >nn [lemma='vbcl'] themet!interceding-token ngrams: / UVRAGtJe1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj Gene_or_gene_productt+interceding-token ngrams: and instead formst&interceding-token ngrams: higher ordertWe1: trigger-arg-path: Negative_activation >dobj [lemma='beclin-1'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >dobj [lemma='beclin-1'] Gene_or_gene_producttRshortest-path: dobj [lemma='beclin-1'] >dep [lemma='uvrag']tUe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >nsubj controllert/interceding-token ngrams: higher order Beclin-1tNe1: trigger-arg-path: disrupts:Negative_activation >nsubj Gene_or_gene_producttRe2: trigger-arg-path: Binding nsubj [lemma='cbcl-2'] controllert interceding-token ngrams: highert:e1: trigger-arg-path: disrupts >nsubj Gene_or_gene_producttOe1: trigger-arg-path: Negative_activation >dobj controlled:Gene_or_gene_productt%interceding-token ngrams: and insteadtMe1: trigger-arg-path: disrupts:Negative_activation >dobj Gene_or_gene_productte1: trigger: disruptst+interceding-token ngrams: complex , whereast0e1: trigger-arg-path: disrupts >nsubj controllert)interceding-token ngrams: vBcl-2 does nottOe2: trigger-arg-path: lemmatizedTrigger=complex nsubj [lemma='cbcl-2'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex nsubj controller:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vbcl'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >dobj [lemma='beclin-1'] controlledt%interceding-token ngrams: vBcl-2 doestMe2: trigger-arg-path: complex:Binding >nn [lemma='vbcl'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >dobj controlled:Gene_or_gene_producttVe1: trigger-arg-path: Negative_activation >nsubj [lemma='cbcl-2'] Gene_or_gene_producttZe2: trigger-arg-path: complex:Binding nn [lemma='vbcl'] themet6e2: trigger-arg-path: complex >nn [lemma='vbcl'] themetUe1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj controlled:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >dobj controlledt!interceding-token ngrams: forms atfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dobj [lemma='beclin-1'] controlled:Gene_or_gene_productt)interceding-token ngrams: instead forms atLe1: trigger-arg-path: disrupts >dobj [lemma='beclin-1'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj [lemma='beclin-1'] controlled:Gene_or_gene_productt`trigger-to-trigger-path: e1:disrupts:Negative_activation >conj_and >dobj >dep e2:complex:Bindingtae1: trigger-arg-path: Negative_activation >nsubj [lemma='cbcl-2'] controller:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj controlledt9e1: trigger-arg-path: disrupts >dobj Gene_or_gene_producttMe1: trigger-arg-path: Negative_activation >dobj [lemma='beclin-1'] controlledt#interceding-token ngrams: not , andt_e1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >nsubj Gene_or_gene_productt'interceding-token ngrams: , and insteadtUe1: trigger-arg-path: disrupts:Negative_activation >nsubj [lemma='cbcl-2'] controllertpe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >nsubj [lemma='cbcl-2'] Gene_or_gene_productt4e1: args2Role-mention-ngram: disrupts the CONTROLLEDtDe1: trigger-arg-path: disrupts:Negative_activation >nsubj controllert'interceding-token ngrams: instead formstinterceding-token ngrams: UVRAGtKe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj Gene_or_gene_productt shortest-path: dobj >dept)e1: args2Role-mention-ngram: disrupts thetLe2: trigger-arg-path: complex dobj controlledt]e1: trigger-arg-path: lemmatizedTrigger=disrupt >dobj [lemma='beclin-1'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='vbcl'] Gene_or_gene_producttXe1: trigger-arg-path: disrupts:Negative_activation >dobj controlled:Gene_or_gene_producttAe1: trigger-arg-path: disrupts >nsubj [lemma='cbcl-2'] controllertWe1: trigger-arg-path: disrupts >dobj [lemma='beclin-1'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='cbcl-2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='vbcl'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_activation >dobj Gene_or_gene_producttuinterceding-tokens-full-span: / UVRAG complex , whereas vBcl-2 does not , and instead forms a higher order Beclin-1 /tke1: trigger-arg-path: disrupts:Negative_activation >dobj [lemma='beclin-1'] controlled:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vbcl'] Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='vbcl'] theme:Gene_or_gene_productt(interceding-token ngrams: a higher ordertEe1: trigger-arg-path: disrupts >nsubj controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:disrupts:Negative_activation >conj_and [lemma='form'] >dobj [lemma='beclin-1'] >dep [lemma='complex'] e2:complex:Bindingt0e1: args2Role-mention-ngram: CONTROLLER disruptstje1: trigger-arg-path: disrupts:Negative_activation >nsubj [lemma='cbcl-2'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='vbcl'] theme:Gene_or_gene_producttBe1: trigger-arg-path: disrupts >dobj [lemma='beclin-1'] controlledtKe2: trigger-arg-path: complex >nn [lemma='vbcl'] theme:Gene_or_gene_productt-interceding-token ngrams: whereas vBcl-2 doest/e1: ents2Label-mention-ngram: SAFB1 ) interactst_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='prc2'] Gene_or_gene_producttje2: trigger-arg-path: represses >dobj [lemma='machinery'] >nn [lemma='ar'] controlled:Gene_or_gene_producttie2: trigger-arg-path: represses:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlledt.e2: args2Role-mention-ngram: CONTROLLER and ARt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlled:Gene_or_gene_productt%e2: ents2Label-mention-ngram: ( SAFB1tVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='prc2'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='prc2'] Gene_or_gene_productt\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='prc2'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='prc2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='machinery'] >nn [lemma='ar'] controlledtie2: trigger-arg-path: Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] Gene_or_gene_productt-e2: args2Role-mention-ngram: AR and repressest%e1: ents2Label-mention-ngram: ( SAFB1tRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='b1'] themet$e1: args2Role-mention-ngram: THEME (t_e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='b1'] theme:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='machinery'] >nn [lemma='ar'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: ) interactst.e1: ents2Label-mention-ngram: ) interacts witht(e2: ents2Label-mention-ngram: and AR andt'e2: args2Role-mention-ngram: and AR andtVe1: trigger-arg-path: interacts:Binding >nsubj [lemma='b1'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interacts >prep_with [lemma='prc2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] Gene_or_gene_productt"e1: args2Role-mention-ngram: SAFB1tYe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='b1'] Gene_or_gene_producttNe1: trigger-arg-path: interacts >prep_with [lemma='prc2'] Gene_or_gene_productt e2: ents2Label-mention-ngram: ARtAe1: trigger-arg-path: interacts:Binding >nsubj [lemma='b1'] themet?e1: trigger-arg-path: interacts >prep_with [lemma='prc2'] themetae1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='b1'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: SAFB1 ) interactst$e2: ents2Label-mention-ngram: AR andte2: args2Role-mention-ngram: ARt'e2: ents2Label-mention-ngram: ( SAFB1 )t#e1: ents2Label-mention-ngram: SAFB1tLe1: trigger-arg-path: Binding >nsubj [lemma='b1'] theme:Gene_or_gene_productt-e1: args2Role-mention-ngram: ) interacts withtNe1: trigger-arg-path: interacts >nsubj [lemma='b1'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: ) interactst#e2: ents2Label-mention-ngram: SAFB1tge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='prc2'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED ( SAFB1t%e2: ents2Label-mention-ngram: SAFB1 )t7e1: trigger-arg-path: Binding >nsubj [lemma='b1'] themet8shortest-path: nn [lemma='attachment']t*e1: args2Role-mention-ngram: THEME ( SAFB1t=e1: trigger-arg-path: Binding >prep_with [lemma='prc2'] themet&e1: args2Role-mention-ngram: ( SAFB1 )t.e1: args2Role-mention-ngram: SAFB1 ) interactst#e2: args2Role-mention-ngram: AR andtRe1: trigger-arg-path: Binding >prep_with [lemma='prc2'] theme:Gene_or_gene_productt~e2: trigger-arg-path: represses:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlled:Gene_or_gene_productt%e1: ents2Label-mention-ngram: SAFB1 )tGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='prc2'] themet$e1: args2Role-mention-ngram: SAFB1 )t$e2: ents2Label-mention-ngram: and ARtme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='prc2'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED ( SAFB1t@e2: ents2Label-mention-ngram: and represses GENE_OR_GENE_PRODUCTtPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='prc2'] themet(e1: args2Role-mention-ngram: ) interactstge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='b1'] theme:Gene_or_gene_productt9e1: trigger-arg-path: interacts >nsubj [lemma='b1'] themet'e1: ents2Label-mention-ngram: ( SAFB1 )tPe1: trigger-arg-path: interacts:Binding >nsubj [lemma='b1'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: ) interacts withtte2: trigger-arg-path: Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: represses >dobj [lemma='machinery'] >nn [lemma='ar'] controlledtye2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] controlledtnsubj [lemma='b1'] Gene_or_gene_productt_e2: trigger-arg-path: represses >dobj [lemma='machinery'] >nn [lemma='ar'] Gene_or_gene_producttse2: trigger-arg-path: represses:Negative_activation >dobj [lemma='machinery'] >nn [lemma='ar'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: SHARED and ARtXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='prc2'] themet#e2: args2Role-mention-ngram: and ARtJe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='b1'] themetHe1: trigger-arg-path: interacts >nsubj [lemma='b1'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='machinery'] >nn [lemma='ar'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: AR and repressest$e1: args2Role-mention-ngram: ( SAFB1t interceding-token ngrams: of NIKt5e1: args2Role-mention-ngram: and stimulate CONTROLLEDtSe1: trigger-arg-path: stimulate:Positive_activation dobj [lemma='expression'] >nn [lemma='p100'] Gene_or_gene_producttinterceding-token ngrams: NIKtqtrigger-to-trigger-path: e1:stimulate:Positive_activation advcl e2:interact:BindingtPe1: trigger-arg-path: stimulate:Positive_activation advcl >nsubjte1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='expression'] >nn [lemma='p100'] controlled:Gene_or_gene_producttGe1: trigger-arg-path: stimulate dobj [lemma='expression'] >nn [lemma='p100'] controlledt6interceding-token ngrams: and processing independentlytMe1: trigger-arg-path: stimulate:Positive_activation dobj [lemma='expression'] >nn [lemma='p100'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCT andt3interceding-token ngrams: expression and processingt[e1: trigger-arg-path: stimulate:Positive_activation advcl [lemma='interact'] e2:interact:Bindingt~e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p100'] controlledt,e1: ents2Label-mention-ngram: vFLIP interactt"e1: ents2Label-mention-ngram: KSHVt?e1: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p100'] controlled:Gene_or_gene_productt'interceding-token ngrams: NIK , whereast"interceding-token ngrams: of NIK ,tje1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='expression'] >nn [lemma='p100'] controlledtwe1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='p100'] controlled:Gene_or_gene_productt1e1: ents2Label-mention-ngram: vFLIP interact withtTe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation dobj [lemma='expression'] >nn [lemma='p100'] controlled:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=stimulate dobj [lemma='expression'] >nn [lemma='p100'] controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: KSHV vFLIPtle1: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p100'] controlledtCe1: trigger-arg-path: Positive_activation dobj [lemma='expression'] >nn [lemma='p100'] Gene_or_gene_productt(interceding-token ngrams: and processingt+e1: ents2Label-mention-ngram: and stimulatet&e1: ents2Label-mention-ngram: and KSHVt5interceding-token ngrams: processing independently oft@e1: ents2Label-mention-ngram: and stimulate GENE_OR_GENE_PRODUCTtWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation dobj [lemma='expression'] >nn [lemma='p100'] Gene_or_gene_producttle1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='p100'] Gene_or_gene_producttinterceding-token ngrams: NIK ,t2interceding-token ngrams: processing independentlytyshortest-path: advcl [lemma='interact'] >nsubj [lemma='tax']tXe1: trigger-arg-path: stimulate >dobj [lemma='expression'] >nn [lemma='p100'] controlledtFe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='EL'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='EL'] Gene_or_gene_productt+e1: args2Role-mention-ngram: CONTROLLER mayt;e1: ents2Label-mention-ngram: activate GENE_OR_GENE_PRODUCTt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Puma'] Gene_or_gene_producttRtrigger-to-trigger-path: e1:activate:Positive_activation nsubj [lemma='Puma'] themet9e2: trigger-arg-path: Binding >nsubj [lemma='Puma'] themetRe1: trigger-arg-path: Positive_activation >dobj [lemma='bax'] Gene_or_gene_productt*e1: args2Role-mention-ngram: directly bindt7e2: trigger-arg-path: Binding >nsubj [lemma='EL'] themetHe2: trigger-arg-path: Binding >nsubj [lemma='Puma'] Gene_or_gene_productt*e2: args2Role-mention-ngram: directly bindtde1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='bax'] controlled:Gene_or_gene_productt-e1: args2Role-mention-ngram: directly bind totEe2: trigger-arg-path: bind >nsubj [lemma='Puma'] Gene_or_gene_producttCe2: trigger-arg-path: bind >nsubj [lemma='EL'] Gene_or_gene_productt4e1: args2Role-mention-ngram: and activate CONTROLLEDtUe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='EL'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Puma'] theme:Gene_or_gene_producttGe1: trigger-arg-path: activate >dobj [lemma='bax'] Gene_or_gene_producttfe1: trigger-arg-path: activate:Positive_activation >dobj [lemma='bax'] controlled:Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='Puma'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: bind to andt,e1: args2Role-mention-ngram: to and activatet/e1: args2Role-mention-ngram: also directly bindtnsubj [lemma='EL'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Puma'] themetce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='bax'] controlledtOe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='bax'] controlledt+e2: ents2Label-mention-ngram: directly bindtSe2: trigger-arg-path: bind:Binding >nsubj [lemma='Puma'] theme:Gene_or_gene_productt=e1: trigger-arg-path: activate >dobj [lemma='bax'] controlledtFe2: trigger-arg-path: Binding >nsubj [lemma='EL'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Puma'] Gene_or_gene_producttQe2: trigger-arg-path: bind:Binding >nsubj [lemma='EL'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: also directly bindtKe2: trigger-arg-path: bind >nsubj [lemma='Puma'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Puma'] themetKe2: trigger-arg-path: bind:Binding >nsubj [lemma='EL'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='EL'] theme:Gene_or_gene_productt4e2: trigger-arg-path: bind >nsubj [lemma='EL'] themetQe1: trigger-arg-path: activate:Positive_activation >dobj [lemma='bax'] controlledtMe2: trigger-arg-path: bind:Binding >nsubj [lemma='Puma'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='EL'] themet+e1: ents2Label-mention-ngram: directly bindt,e1: ents2Label-mention-ngram: and SHARED maytatrigger-to-trigger-path: e1:activate:Positive_activation dobj [lemma='bax'] controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: also directly bindtRe1: trigger-arg-path: activate >dobj [lemma='bax'] controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='bax'] Gene_or_gene_productt[e1: trigger-arg-path: activate:Positive_activation >dobj [lemma='bax'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='bax'] Gene_or_gene_productt/e2: args2Role-mention-ngram: also directly bindt-e1: ents2Label-mention-ngram: to and activatet?e1: ents2Label-mention-ngram: and activate GENE_OR_GENE_PRODUCTt*e2: args2Role-mention-ngram: and THEME mayt,e2: ents2Label-mention-ngram: and SHARED maytshortest-path: nsubj [lemma='EL'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: directly bind tot>e2: trigger-arg-path: bind:Binding >nsubj [lemma='Puma'] themet0e1: args2Role-mention-ngram: CONTROLLER may alsot]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Puma'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='EL'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: bind to andt)e1: args2Role-mention-ngram: and activatetHe1: trigger-arg-path: Positive_activation >dobj [lemma='bax'] controlledtIe2: trigger-arg-path: bind >nsubj [lemma='EL'] theme:Gene_or_gene_productt]e1: trigger-arg-path: Positive_activation >dobj [lemma='bax'] controlled:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_producttge2: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_producttBe1: trigger-arg-path: inhibit nsubjpass controlled:Bindingtpe2: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass Bindingt2e1: args2Role-mention-ngram: activation of ERalphatLe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass controlledt1e1: ents2Label-mention-ngram: ERalpha acetylationtXe1: trigger-arg-path: inhibit nsubjpass [lemma='pp32'] controlledt9e1: ents2Label-mention-ngram: activation of transcriptiontte1: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='pp32'] controlled:Bindingt1e1: args2Role-mention-ngram: CONTROLLED ( ERalphat;e1: trigger-arg-path: inhibit >prep_by Gene_or_gene_productt(e1: ents2Label-mention-ngram: of ERalphat1e1: ents2Label-mention-ngram: transcription , andtTe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] themet-e2: ents2Label-mention-ngram: also been shownt1e1: ents2Label-mention-ngram: inhibit the ERalphat1e1: args2Role-mention-ngram: the ERalpha mediatedtse2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] themet$e1: ents2Label-mention-ngram: and tot.e2: args2Role-mention-ngram: shown to interactt+e1: args2Role-mention-ngram: acetylation bytee2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass theme:Gene_or_gene_producttKe2: trigger-arg-path: interact nsubjpass theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: activation of ERalphatUe1: trigger-arg-path: inhibit >prep_by [lemma='p300'] controller:Gene_or_gene_producttme2: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: to interact witht0e1: args2Role-mention-ngram: ERalpha acetylationt3e1: args2Role-mention-ngram: inhibit the activationt+e1: args2Role-mention-ngram: to inhibit thetDe2: trigger-arg-path: Binding nsubjpass Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass themet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: the activation oft.e1: ents2Label-mention-ngram: of transcriptiont"e2: ents2Label-mention-ngram: beentae2: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] themet)e2: ents2Label-mention-ngram: to interactt(e1: args2Role-mention-ngram: ( ERalpha )t&e2: args2Role-mention-ngram: pp32 havetSe2: trigger-arg-path: interact:Binding nsubjpass theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: shown totXe1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: inhibit the activationtle1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: CONTROLLED (t"e2: ents2Label-mention-ngram: havet/e1: args2Role-mention-ngram: of transcription ,t(e2: args2Role-mention-ngram: to interactt'e2: ents2Label-mention-ngram: pp32 havetke2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] themetXe2: trigger-arg-path: Binding nsubjpass [lemma='TAF-1beta'] themet1e1: trigger-arg-path: inhibit >prep_by controllert!e2: args2Role-mention-ngram: pp32t)e1: args2Role-mention-ngram: , to inhibitt=e1: trigger-arg-path: Negative_regulation >prep_by controllert8e1: args2Role-mention-ngram: activation of transcriptiontre1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='pp32'] controlled:Bindingt+e2: args2Role-mention-ngram: have also beent&e1: args2Role-mention-ngram: ( ERalphat,e1: ents2Label-mention-ngram: the activationt9e1: ents2Label-mention-ngram: ERalpha mediated activationt,e2: ents2Label-mention-ngram: have also beent/e2: ents2Label-mention-ngram: shown to interacttNe1: trigger-arg-path: inhibit:Negative_regulation nsubjpass controlledt]e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass Bindingtae1: trigger-arg-path: Negative_regulation nsubjpass [lemma='pp32'] Bindingt_e2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass Gene_or_gene_producttGe1: trigger-arg-path: Negative_regulation >prep_by Gene_or_gene_producttNe1: trigger-arg-path: Negative_regulation nsubjpass controlled:Bindingt$e1: args2Role-mention-ngram: ERalphat#e1: args2Role-mention-ngram: and tothtrigger-to-trigger-path: e1:inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: ERalphat)e1: ents2Label-mention-ngram: the ERalphat`e1: trigger-arg-path: inhibit nsubjpass [lemma='pp32'] controlled:Bindingt8e1: args2Role-mention-ngram: ERalpha mediated activationt-e2: args2Role-mention-ngram: to interact withtYe2: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] Gene_or_gene_producttle1: trigger-arg-path: Negative_regulation nsubjpass [lemma='pp32'] controlled:Bindingt&e2: ents2Label-mention-ngram: shown tot^e1: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: with SHARED (t0e1: args2Role-mention-ngram: transcription , andt-e1: args2Role-mention-ngram: of transcriptiont0e1: args2Role-mention-ngram: inhibit the ERalphatnsubjpass themet,e2: args2Role-mention-ngram: also been showntWe2: trigger-arg-path: interact >prep_with [lemma='receptor'] theme:Gene_or_gene_producttBe2: trigger-arg-path: interact >prep_with [lemma='receptor'] themetae1: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: ( ERalphatTe1: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] controllert.e1: ents2Label-mention-ngram: SHARED ( ERalphat3e1: args2Role-mention-ngram: of ERalpha acetylationtVe2: trigger-arg-path: Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: of transcription ,t.e1: ents2Label-mention-ngram: ERalpha mediatedt'e2: ents2Label-mention-ngram: also beentPe2: trigger-arg-path: Binding >prep_with [lemma='receptor'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: ERalpha ) ,t4e1: ents2Label-mention-ngram: of ERalpha acetylationtQe2: trigger-arg-path: interact >prep_with [lemma='receptor'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: transcriptiontge1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='pp32'] Bindingt3e1: args2Role-mention-ngram: ERalpha acetylation byt,e1: ents2Label-mention-ngram: acetylation bytce2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] Gene_or_gene_producttUtrigger-to-trigger-path: e1:inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_producttOe1: trigger-arg-path: inhibit:Negative_regulation >prep_by Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] themet,e1: ents2Label-mention-ngram: to inhibit thetae1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] Gene_or_gene_productt,e1: args2Role-mention-ngram: transcription ,t&e1: args2Role-mention-ngram: ERalpha )t+e1: args2Role-mention-ngram: and to inhibittde1: trigger-arg-path: Negative_regulation nsubjpass [lemma='pp32'] controlledt*e2: args2Role-mention-ngram: and pp32 havet5e2: trigger-arg-path: Binding nsubjpass themethe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass controlled:Bindingtqe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_producttEe2: trigger-arg-path: interact nsubjpass Gene_or_gene_productt1e1: ents2Label-mention-ngram: mediated activationtje1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='pp32'] controlledt(e1: args2Role-mention-ngram: the ERalphatze2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] Gene_or_gene_productt!e1: args2Role-mention-ngram: , tot/e1: ents2Label-mention-ngram: the activation oftWe2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass Gene_or_gene_producttEe1: trigger-arg-path: inhibit:Negative_regulation >prep_by controllert(e2: ents2Label-mention-ngram: been shownt]e2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: showntCe1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by controllert~e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='pp32'] controlledtve2: trigger-arg-path: interact:Binding nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: acetylation by CONTROLLERtie1: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='pp32'] Bindingt+e2: args2Role-mention-ngram: pp32 have alsot,shortest-path: nsubjpass controlledt,e2: ents2Label-mention-ngram: pp32 have alsotCe1: trigger-arg-path: Negative_regulation nsubjpass BindingtZe1: trigger-arg-path: inhibit:Negative_regulation >prep_by controller:Gene_or_gene_producttAe1: ents2Label-mention-ngram: acetylation by GENE_OR_GENE_PRODUCTt'e2: args2Role-mention-ngram: been showntWe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by controllert+e2: ents2Label-mention-ngram: and pp32 havet_e2: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='pp32'] controlled:BindingtJe2: trigger-arg-path: Binding nsubjpass theme:Gene_or_gene_producttVe1: trigger-arg-path: inhibit:Negative_regulation nsubjpass controlled:Bindingt4e1: ents2Label-mention-ngram: ERalpha acetylation byt$e1: ents2Label-mention-ngram: ) , tot-e1: args2Role-mention-ngram: ERalpha mediatedt*e1: args2Role-mention-ngram: transcriptiont2e1: ents2Label-mention-ngram: the ERalpha mediatedt%e1: args2Role-mention-ngram: , and tot(e1: args2Role-mention-ngram: ERalpha ) ,t{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='pp32'] Bindingt*e1: ents2Label-mention-ngram: , to inhibitt*e2: args2Role-mention-ngram: been shown tot"e2: ents2Label-mention-ngram: pp32t4e1: ents2Label-mention-ngram: mediated activation oftJe2: trigger-arg-path: interact:Binding >prep_with [lemma='receptor'] themetshortest-path: nsubjpass [lemma='pp32'] Bindingtfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] controllertVe1: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='receptor'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='receptor'] theme:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and pp32tTe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass controlled:Bindingt#e1: args2Role-mention-ngram: ) , tot&e1: ents2Label-mention-ngram: , and totge1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] controller:Gene_or_gene_producttLe1: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] controllertMe1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by Gene_or_gene_producttJe1: trigger-arg-path: inhibit >prep_by [lemma='p300'] Gene_or_gene_producttle1: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='pp32'] controlledt-e1: ents2Label-mention-ngram: transcription ,tYe2: trigger-arg-path: interact nsubjpass [lemma='TAF-1beta'] themetRe1: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] controllertHe2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass themet:e1: trigger-arg-path: inhibit nsubjpass controlledt&e2: ents2Label-mention-ngram: and pp32t+e2: args2Role-mention-ngram: THEME and pp32tKe1: trigger-arg-path: inhibit:Negative_regulation nsubjpass Bindingt7e1: trigger-arg-path: inhibit nsubjpass Bindingt0e1: args2Role-mention-ngram: mediated activationt+e2: ents2Label-mention-ngram: been shown totRe1: trigger-arg-path: Negative_regulation >prep_by controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: beent,e1: ents2Label-mention-ngram: and to inhibitt)e1: ents2Label-mention-ngram: ( ERalpha )t+e1: args2Role-mention-ngram: the activationt!e2: args2Role-mention-ngram: havetFe1: trigger-arg-path: inhibit >prep_by controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: of ERalphatFe1: trigger-arg-path: Negative_regulation nsubjpass controlledt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT havet@e1: trigger-arg-path: inhibit >prep_by [lemma='p300'] controllertie1: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_productt>e2: trigger-arg-path: interact:Binding nsubjpass themet?e2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='TAF-1beta'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interact:Binding nsubjpass Gene_or_gene_productt"e1: ents2Label-mention-ngram: , totAe2: trigger-arg-path: Binding >prep_with [lemma='receptor'] themet2e2: args2Role-mention-ngram: deficient CLS patientt"e2: ents2Label-mention-ngram: RSK2t4e2: ents2Label-mention-ngram: and re-introduction oft&e1: args2Role-mention-ngram: human CLStAe1: trigger-arg-path: lemmatizedTrigger=abolish nsubj controller:Gene_or_gene_productt_e1: trigger-arg-path: Negative_regulation nsubj controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: H3 phosphorylationtee2: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: are abolishedt$e2: args2Role-mention-ngram: patientt*e2: ents2Label-mention-ngram: RSK2 to RSK2t$e2: args2Role-mention-ngram: to RSK2tVe2: trigger-arg-path: lemmatizedTrigger=restore >nsubj controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: serine 10t'e2: ents2Label-mention-ngram: cells aret/e2: ents2Label-mention-ngram: EGF stimulation ,t&e1: args2Role-mention-ngram: cells aret*e2: args2Role-mention-ngram: stimulation ,t&e2: args2Role-mention-ngram: cells aret,e2: args2Role-mention-ngram: EGF stimulationt1e2: ents2Label-mention-ngram: and re-introductiont)e2: ents2Label-mention-ngram: stimulationt-e2: ents2Label-mention-ngram: deficient humantJe1: trigger-arg-path: abolished nsubj Gene_or_gene_productt3e2: args2Role-mention-ngram: re-introduction of thet!e1: ents2Label-mention-ngram: aret0e2: args2Role-mention-ngram: deficient human CLStDe2: trigger-arg-path: restores:Positive_regulation >nsubj controllert:e2: trigger-arg-path: restores >nsubj Gene_or_gene_productt)e2: args2Role-mention-ngram: serine 10 byt+e1: ents2Label-mention-ngram: CLS cells aret+e2: ents2Label-mention-ngram: abolished thet*e2: args2Role-mention-ngram: the wild-typete2: args2Role-mention-ngram: H3t'e1: ents2Label-mention-ngram: deficientt'e1: ents2Label-mention-ngram: human CLSt4e1: ents2Label-mention-ngram: SHARED deficient humant0e2: trigger-arg-path: restores >nsubj controllert8e2: ents2Label-mention-ngram: histone H3 phosphorylationt.e2: args2Role-mention-ngram: are abolished thet0e2: args2Role-mention-ngram: cells are abolishedt&e2: ents2Label-mention-ngram: restorest(e2: args2Role-mention-ngram: EGF inducedtPe2: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='rsk2'] controllert,e2: args2Role-mention-ngram: deficient humant1e2: args2Role-mention-ngram: restores EGF inducedtTe1: trigger-arg-path: abolished:Negative_regulation nsubj [lemma='rsk2'] controllertPe1: trigger-arg-path: lemmatizedTrigger=abolish nsubj [lemma='rsk2'] controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: 10 byt7e2: args2Role-mention-ngram: histone H3 phosphorylationt&e2: args2Role-mention-ngram: serine 10t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: patient cellst2e2: ents2Label-mention-ngram: restores EGF inducedt)e2: args2Role-mention-ngram: at serine 10t+e2: ents2Label-mention-ngram: stimulation ,t/e2: args2Role-mention-ngram: RSK2 deficient CLSt8e1: ents2Label-mention-ngram: the SHARED phosphorylationt;e1: trigger-arg-path: abolished nsubj [lemma='rsk2'] controllert.e2: args2Role-mention-ngram: wild-type RSK2 tot/e2: args2Role-mention-ngram: by EGF stimulationt#e2: ents2Label-mention-ngram: 10 byt/e2: args2Role-mention-ngram: phosphorylation att,e2: args2Role-mention-ngram: re-introductiont,e2: ents2Label-mention-ngram: cells restorestZe1: trigger-arg-path: lemmatizedTrigger=abolish nsubj [lemma='rsk2'] Gene_or_gene_producttPe1: trigger-arg-path: Negative_regulation nsubj [lemma='rsk2'] controllert.e1: args2Role-mention-ngram: are abolished thet3e2: ents2Label-mention-ngram: , and re-introductiont!e2: ents2Label-mention-ngram: CLSt4e2: ents2Label-mention-ngram: patient cells restorest'e2: ents2Label-mention-ngram: abolishedt(e2: args2Role-mention-ngram: the histonet+e2: ents2Label-mention-ngram: deficient CLSte1: trigger: abolishedt.e2: args2Role-mention-ngram: stimulation , andt$e2: args2Role-mention-ngram: RSK2 tot/e2: ents2Label-mention-ngram: CLS patient cellst0e2: ents2Label-mention-ngram: by EGF stimulationt+e1: ents2Label-mention-ngram: abolished thet+e2: ents2Label-mention-ngram: patient cellst*e1: args2Role-mention-ngram: are abolishedt.e2: args2Role-mention-ngram: to RSK2 deficientt2e2: args2Role-mention-ngram: abolished the histonet,e1: args2Role-mention-ngram: human CLS cellst@e1: trigger-arg-path: abolished nsubj [lemma='rsk2'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: deficient human CLStAe2: trigger-arg-path: lemmatizedTrigger=restore >nsubj controllert"e1: args2Role-mention-ngram: humant4e2: ents2Label-mention-ngram: re-introduction of thet'e2: args2Role-mention-ngram: histone H3te2: args2Role-mention-ngram: 10t#e1: ents2Label-mention-ngram: humant/e2: args2Role-mention-ngram: the wild-type RSK2t$e2: ents2Label-mention-ngram: by EGFt*e1: args2Role-mention-ngram: CLS cells aretUe2: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj controllert2e1: ents2Label-mention-ngram: abolished the SHAREDte2: outgoing: >iobjtie1: trigger-arg-path: abolished:Negative_regulation nsubj [lemma='rsk2'] Gene_or_gene_producttEe1: trigger-arg-path: abolished:Negative_regulation nsubj controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: CLS cells aret*e2: ents2Label-mention-ngram: restores EGFt'e2: ents2Label-mention-ngram: deficientt&e2: args2Role-mention-ngram: abolishedtUe1: trigger-arg-path: abolished nsubj [lemma='rsk2'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: to RSK2 deficienttgtrigger-to-trigger-path: e1:abolished:Negative_regulation nsubj Gene_or_gene_productt,e2: ents2Label-mention-ngram: wild-type RSK2t0e2: ents2Label-mention-ngram: the wild-type RSK2t$e2: args2Role-mention-ngram: histonet.e2: ents2Label-mention-ngram: SHARED deficientt+e2: args2Role-mention-ngram: wild-type RSK2t)e2: ents2Label-mention-ngram: CLS patientt6e2: args2Role-mention-ngram: phosphorylation at serinet,e2: ents2Label-mention-ngram: the histone H3t'e1: ents2Label-mention-ngram: abolishedt4e2: ents2Label-mention-ngram: SHARED deficient humant]e2: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: EGF induced SHAREDt0e1: args2Role-mention-ngram: cells are abolishedt3e2: args2Role-mention-ngram: patient cells restorestne2: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_productt"e2: args2Role-mention-ngram: humant+e2: args2Role-mention-ngram: the histone H3t-e1: ents2Label-mention-ngram: human CLS cellsthe2: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: human CLSt&e1: args2Role-mention-ngram: deficienttJe1: trigger-arg-path: Negative_regulation nsubj Gene_or_gene_productt#e2: ents2Label-mention-ngram: humant#e2: args2Role-mention-ngram: by EGFt7e1: args2Role-mention-ngram: CONTROLLER deficient humant7e2: ents2Label-mention-ngram: phosphorylation at serinet/e2: ents2Label-mention-ngram: stimulation , andt5e1: args2Role-mention-ngram: abolished the CONTROLLEDt&e2: args2Role-mention-ngram: deficientt3e2: ents2Label-mention-ngram: abolished the histonet%e2: ents2Label-mention-ngram: patientt,e1: args2Role-mention-ngram: deficient humant/e1: ents2Label-mention-ngram: are abolished thet*e1: args2Role-mention-ngram: abolished thet0e1: args2Role-mention-ngram: deficient human CLSt0e2: ents2Label-mention-ngram: cells restores EGFt1e2: ents2Label-mention-ngram: cells are abolishedt*e2: ents2Label-mention-ngram: serine 10 byt.e2: args2Role-mention-ngram: EGF stimulation ,t7e2: ents2Label-mention-ngram: SHARED phosphorylation att?e2: trigger-arg-path: restores >nsubj [lemma='rsk2'] controllert)e2: ents2Label-mention-ngram: EGF inducedt.e1: ents2Label-mention-ngram: SHARED deficienttVe1: trigger-arg-path: lemmatizedTrigger=abolish nsubj [lemma='exchange'] >prep_of [lemma='ra'] theme:Familytce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='exchange'] >prep_of [lemma='ra'] Familyt4e1: trigger-arg-path: Binding >nsubj >prep_of FamilytVe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation dobj [lemma='ra'] Familytie2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='ra'] controlled:FamilytTe2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='exchange'] >prep_of [lemma='ra'] themetTe2: trigger-arg-path: activates:Positive_activation conj_and [lemma='activate'] e2:activates:Positive_activationtUe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='ra'] controlled:FamilytIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of theme:Familyt_e2: trigger-arg-path: activates:Positive_activation nsubj >prep_of theme:Familyt-e2: ents2Label-mention-ngram: SHARED with GTPt-e2: ents2Label-mention-ngram: GTP and therebyt^e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='ra'] Familyt`e1: trigger-arg-path: bound:Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] theme:FamilytMe2: trigger-arg-path: lemmatizedTrigger=activate dobj [lemma='ra'] Familytae2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation dobj [lemma='ra'] controlledt,e2: args2Role-mention-ngram: GTP and therebytDe2: trigger-arg-path: activates >dobj [lemma='ra'] controlled:FamilytZe1: trigger-arg-path: bound:Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] Familyt@e2: trigger-arg-path: activates:Positive_activation >dobj Familyt3e2: ents2Label-mention-ngram: and thereby activatest9e2: trigger-arg-path: activates >dobj [lemma='ra'] Familyt%e2: args2Role-mention-ngram: with GTPt:e1: trigger-arg-path: bound:Binding >nsubj >prep_of FamilytXe1: trigger-arg-path: bound >nsubj [lemma='exchange'] >prep_of [lemma='ra'] theme:Familyt)e2: args2Role-mention-ngram: with GTP andt2e1: trigger-arg-path: bound >nsubj >prep_of Familyt,e2: trigger-arg-path: activates >dobj FamilytKe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of FamilytKe2: trigger-arg-path: activates dobj controlledtbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='exchange'] >prep_of [lemma='ra'] themetdobj controlledtCe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of Familyt7e2: trigger-arg-path: activates >dobj controlled:Familyt\e2: trigger-arg-path: lemmatizedTrigger=activate nsubj >prep_of themet1e2: trigger-arg-path: activates dobj controlled:Familyt.e2: args2Role-mention-ngram: thereby activatestje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] themetMe2: trigger-arg-path: Positive_activation dobj controlled:FamilytQe2: trigger-arg-path: activates:Positive_activation >dobj [lemma='ra'] controlledt8e1: trigger-arg-path: bound >nsubj >prep_of theme:Familyt:e1: trigger-arg-path: Binding >nsubj >prep_of theme:Familyt=e2: trigger-arg-path: lemmatizedTrigger=activate >dobj FamilytNe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='ra'] controlledtSe1: trigger-arg-path: Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] themet>e2: trigger-arg-path: Positive_activation dobj [lemma='ra'] controlled:Familyt/e2: ents2Label-mention-ngram: bound SHARED withtTtrigger-to-trigger-path: e1:bound:Binding >conj_and e2:activates:Positive_activationtJe2: trigger-arg-path: Positive_activation dobj [lemma='ra'] FamilytBe2: trigger-arg-path: lemmatizedTrigger=activate dobj [lemma='ra'] controlled:FamilytWe2: trigger-arg-path: activates:Positive_activation nsubj >prep_of theme:FamilytTe1: trigger-arg-path: Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] Familytke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] FamilytQe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj FamilytKe2: trigger-arg-path: activates:Positive_activation >dobj controlled:Familyt\e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlled:Familytie1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='exchange'] >prep_of [lemma='ra'] theme:Familythe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation dobj [lemma='ra'] controlledt%e2: ents2Label-mention-ngram: GTP andtYe1: trigger-arg-path: bound:Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] themet6e2: trigger-arg-path: Positive_activation >dobj Familytpe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='exchange'] >prep_of [lemma='ra'] Familyt1e1: trigger-arg-path: bound >nsubj >prep_of themetZe1: trigger-arg-path: Binding >nsubj [lemma='exchange'] >prep_of [lemma='ra'] theme:Familytbe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='ra'] controlledtFe2: trigger-arg-path: Positive_activation conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetFe2: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn site:SitetUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ATM'] controllertNe1: trigger-arg-path: phosphorylates >nsubj [lemma='ATM'] Gene_or_gene_productt&e2: args2Role-mention-ngram: at S734 ,tOe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn site:SitetJe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn Sitetde2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetMe2: trigger-arg-path: Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_producttqe2: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet'e2: ents2Label-mention-ngram: at S734 ,t?e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet"e2: ents2Label-mention-ngram: S734tse2: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitet9e2: trigger-arg-path: interacts >conj_and >nsubj >nn sitet?e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME at S734tve2: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet`e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: , and S734tue2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themet\e2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetDe1: trigger-arg-path: phosphorylates >nsubj [lemma='ATM'] controllertWe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: and SITEt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ATM'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and S734tRe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn Sitetqe2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_producttbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt{e2: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitet$e2: ents2Label-mention-ngram: S734 ,tOe2: trigger-arg-path: interacts >nsubj [lemma='ATM'] theme:Gene_or_gene_producttie2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: at S734tQe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitetie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ATM'] controllertoe2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_producttse2: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] SitetWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn site:Sitethe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_producttxe2: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet'e2: args2Role-mention-ngram: , and SITEtIe2: trigger-arg-path: interacts >nsubj [lemma='ATM'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: at S734t{e2: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='ATM'] themetKe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] themet$e2: args2Role-mention-ngram: at S734t#e2: args2Role-mention-ngram: S734 ,t7e2: trigger-arg-path: Binding >conj_and >nsubj >nn sitetse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt9e2: trigger-arg-path: interacts >conj_and >nsubj >nn Sitet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_producttZe2: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetme2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ATM'] controllert(e2: ents2Label-mention-ngram: S734 , andt|e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_producttBe2: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] themet!e2: args2Role-mention-ngram: S734tIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] controllert7e2: trigger-arg-path: Binding >conj_and >nsubj >nn SitetAe2: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn sitet~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: S734 , andtke2: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt?e2: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitetye2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt:e2: trigger-arg-path: interacts >nsubj [lemma='ATM'] themetse2: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_producttconj_and >nsubj >nn site:SitetRe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn sitetme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='ATM'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED at S734t>e2: trigger-arg-path: interacts >conj_and >nsubj >nn site:Sitet"e1: ents2Label-mention-ngram: S734tqe2: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ATM'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn sitetSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] themetYe1: trigger-arg-path: phosphorylates >nsubj [lemma='ATM'] controller:Gene_or_gene_producttAe2: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn Sitet1e2: ents2Label-mention-ngram: a threonine residuet%e1: args2Role-mention-ngram: proteinst"e1: ents2Label-mention-ngram: at at-e1: ents2Label-mention-ngram: SHARED with Aktt-e1: ents2Label-mention-ngram: Akt proteins attZe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controllert e1: args2Role-mention-ngram: Aktt&e1: ents2Label-mention-ngram: with AkttHe2: trigger-arg-path: phosphorylate:Positive_regulation nsubj >prep_of Gene_or_gene_productt`e1: trigger-arg-path: causes:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt_e1: trigger-arg-path: causes >nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controllert0e1: args2Role-mention-ngram: CONTROLLER with AkttAe1: trigger-arg-path: causes >nsubj >prep_of Gene_or_gene_productt,e1: args2Role-mention-ngram: proteins at thet&e1: ents2Label-mention-ngram: proteinst.e1: args2Role-mention-ngram: causes CONTROLLEDtXe2: trigger-arg-path: phosphorylate nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >prep_of controllert*e1: ents2Label-mention-ngram: Akt proteinstSe2: trigger-arg-path: Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: membranetqe1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttLe1: trigger-arg-path: causes >nsubj >prep_of controller:Gene_or_gene_productt\shortest-path: dobj [lemma='pdk1']t]e2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: threonine residuetRe1: trigger-arg-path: lemmatizedTrigger=cause >nsubj >prep_of Gene_or_gene_productt.e1: args2Role-mention-ngram: with Akt proteinst?e1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: CONTROLLER to CONTROLLEDt3e1: args2Role-mention-ngram: plasma membrane causest?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: membrane causest+e1: ents2Label-mention-ngram: causes SHAREDt5e2: ents2Label-mention-ngram: SHARED to phosphorylatet,e1: ents2Label-mention-ngram: at a threoninet*e1: args2Role-mention-ngram: at the plasmat$e1: ents2Label-mention-ngram: causest%e2: ents2Label-mention-ngram: residuet~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >prep_of controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] Gene_or_gene_productt>e2: trigger-arg-path: phosphorylate nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] Gene_or_gene_producttOe2: trigger-arg-path: Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controllert$e1: ents2Label-mention-ngram: at thet7e1: trigger-arg-path: causes >nsubj >prep_of controllert(e1: args2Role-mention-ngram: proteins attle2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controllert-e1: ents2Label-mention-ngram: proteins at thetWe2: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controller:Gene_or_gene_producttie1: trigger-arg-path: causes >nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] Gene_or_gene_producttKe1: trigger-arg-path: causes:Positive_regulation >nsubj >prep_of controllertPe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] controllertIe2: trigger-arg-path: Positive_regulation dobj >vmod e2:phosphorylate:Positive_regulationt.e1: ents2Label-mention-ngram: to phosphorylatet#e1: args2Role-mention-ngram: causestUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj >prep_of Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='colocalization'] >prep_of [lemma='pdk1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: at a threoninet1e1: ents2Label-mention-ngram: a threonine residuet#e1: args2Role-mention-ngram: at thet2e1: ents2Label-mention-ngram: phosphorylate SHAREDt/e1: ents2Label-mention-ngram: with Akt proteinst?trigger-to-trigger-path: e1:causes:Positive_regulation >dobj [lemma='pdk1'] >vmod [lemma='phosphorylate'] e2:phosphorylate:Positive_regulationt%e1: ents2Label-mention-ngram: residuet)e1: ents2Label-mention-ngram: SHARED witht7e1: args2Role-mention-ngram: membrane causes CONTROLLEDt/e2: ents2Label-mention-ngram: threonine residuet4e2: trigger-arg-path: phosphorylate nsubj >prep_of controllert,e1: args2Role-mention-ngram: membrane causest)e2: ents2Label-mention-ngram: a threoninet)e2: ents2Label-mention-ngram: SHARED at atoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj Simple_chemicalt`trigger-to-trigger-path: e1:suppressed:Negative_regulation >ccomp e2:induced:Positive_regulationtBe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controllert=e1: ents2Label-mention-ngram: phosphorylation and degradationtbe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='peitc'] controller:Simple_chemicaltRe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controller:Simple_chemicaltKe1: trigger-arg-path: Negative_regulation >nsubj [lemma='peitc'] controllert[e1: trigger-arg-path: Negative_regulation >nsubj [lemma='peitc'] controller:Simple_chemicaltve1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='peitc'] controller:Simple_chemicaltnsubj [lemma='lp'] controllert7e1: ents2Label-mention-ngram: suppressed SHARED inducedte1: trigger: suppressedtfe1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='peitc'] controller:Simple_chemicaltfe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj controller:Simple_chemicalt=e2: ents2Label-mention-ngram: phosphorylation and degradationtBe1: trigger-arg-path: suppressed >nsubj controller:Simple_chemicalt]e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='lp'] controller:Simple_chemicaltGe1: trigger-arg-path: suppressed >nsubj [lemma='peitc'] Simple_chemicaltRe1: trigger-arg-path: suppressed >nsubj [lemma='peitc'] controller:Simple_chemicaltMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='lp'] controllertMe2: trigger-arg-path: Positive_regulation >nsubj [lemma='lp'] Simple_chemicaltVe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj controllert-e1: ents2Label-mention-ngram: also suppressedtUe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='lp'] Simple_chemicalt9e2: ents2Label-mention-ngram: induced phosphorylation andtVe1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='peitc'] controllert=e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL also suppressedt2e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL alsotVshortest-path: ccomp [lemma='decrease'] >nsubj [lemma='lp']tae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='lp'] controllertfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='lp'] Simple_chemicalt7e1: args2Role-mention-ngram: also suppressed CONTROLLEDt`e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='lp'] controller:Simple_chemicalt-e1: ents2Label-mention-ngram: and degradationtFe1: trigger-arg-path: suppressed:Negative_regulation >nsubj controllert(e1: ents2Label-mention-ngram: suppressedt3e1: ents2Label-mention-ngram: degradation of SHAREDtRe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='lp'] Simple_chemicaltRe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='peitc'] controllert,e1: ents2Label-mention-ngram: degradation oft4e1: ents2Label-mention-ngram: also suppressed SHAREDt'e1: args2Role-mention-ngram: suppressedt/e1: ents2Label-mention-ngram: suppressed SHAREDtLe2: trigger-arg-path: induced >nsubj [lemma='lp'] controller:Simple_chemicaltqtrigger-to-trigger-path: e1:suppressed:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationtfe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='peitc'] controllert7e1: args2Role-mention-ngram: CONTROLLER also suppressedt2e1: trigger-arg-path: suppressed >nsubj controllertPe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='lp'] controllert7e1: trigger-arg-path: suppressed >nsubj Simple_chemicalt,e1: args2Role-mention-ngram: also suppressedtKe1: trigger-arg-path: suppressed:Negative_regulation >nsubj Simple_chemicaltke1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='peitc'] Simple_chemicaltBe1: trigger-arg-path: suppressed >nsubj [lemma='peitc'] controllert0e1: ents2Label-mention-ngram: and degradation oftAe2: trigger-arg-path: induced >nsubj [lemma='lp'] Simple_chemicaltXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='lp'] controller:Simple_chemicalt[e1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='peitc'] Simple_chemicaltPe1: trigger-arg-path: Negative_regulation >nsubj [lemma='peitc'] Simple_chemicaltVe1: trigger-arg-path: suppressed:Negative_regulation >nsubj controller:Simple_chemicaltqe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='lp'] controller:Simple_chemicaltWe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='peitc'] Simple_chemicalt)e1: ents2Label-mention-ngram: degradationt2e1: args2Role-mention-ngram: suppressed CONTROLLEDtHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='lp'] controllertGe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj Simple_chemicaltge2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='tip60'] controller:Gene_or_gene_productt8e1: trigger-arg-path: induced >nsubj [lemma='ra'] Familytpe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='tip60'] Gene_or_gene_productt)e1: args2Role-mention-ngram: facilitatingt,e1: args2Role-mention-ngram: by facilitatingt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] Familyt3e1: args2Role-mention-ngram: induced transformationt`e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn Gene_or_gene_productt,e1: ents2Label-mention-ngram: and subsequenttHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] controllert4e1: ents2Label-mention-ngram: induced transformationtRe2: trigger-arg-path: Positive_regulation >nn [lemma='tip60'] Gene_or_gene_productt?trigger-to-trigger-path: e1:induced:Positive_regulation >prepc_by [lemma='facilitate'] >dobj [lemma='acetylation'] e2:acetylation:Positive_regulationt4e1: ents2Label-mention-ngram: SHARED acetylation andtnsubj Familyt\e2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='tip60'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:Familyt+e1: args2Role-mention-ngram: transformationtLe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn Gene_or_gene_productt1e1: ents2Label-mention-ngram: facilitating SHAREDt@e2: trigger-arg-path: acetylation >nn [lemma='tip60'] controllert^e2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='tip60'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: facilitatingt6e1: args2Role-mention-ngram: induced transformation bytNe2: trigger-arg-path: acetylation:Positive_regulation >nn Gene_or_gene_producttushortest-path: prepc_by [lemma='facilitate'] >dobj [lemma='acetylation'] >nn [lemma='tip60']tTe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='tip60'] controllert.e1: args2Role-mention-ngram: transformation byt4e1: args2Role-mention-ngram: facilitating CONTROLLEDt4e2: ents2Label-mention-ngram: subsequent degradationtMe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] controllert;e1: ents2Label-mention-ngram: FAMILY induced transformationtae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] controllerthe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] controller:Familyt8e1: ents2Label-mention-ngram: acetylation and subsequentt{e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='tip60'] controller:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] Familyt-e1: ents2Label-mention-ngram: acetylation andt)shortest-path: prepc_by >dobj >nntYe2: trigger-arg-path: acetylation:Positive_regulation >nn controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: FAMILY inducedt7e2: ents2Label-mention-ngram: subsequent degradation oft+e1: trigger-arg-path: induced >nsubj FamilytTe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] controller:Familyt8e1: ents2Label-mention-ngram: and subsequent degradationtJe2: trigger-arg-path: acetylation >nn [lemma='tip60'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: by facilitating SHAREDtnn [lemma='tip60'] controllert4e2: ents2Label-mention-ngram: SHARED acetylation andtJe1: trigger-arg-path: induced:Positive_regulation >nsubj controller:Familyt-e1: ents2Label-mention-ngram: by facilitatingtUe2: trigger-arg-path: acetylation >nn [lemma='tip60'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: transformationtnsubj [lemma='ra'] controllertCe1: trigger-arg-path: induced >nsubj [lemma='ra'] controller:FamilytBe1: trigger-arg-path: Positive_regulation >nsubj controller:Familyt=e1: ents2Label-mention-ngram: facilitating SHARED acetylationt:e2: trigger-arg-path: acetylation >nn Gene_or_gene_productt7e1: ents2Label-mention-ngram: subsequent degradation oftDe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] Familyt7e1: trigger-arg-path: Positive_regulation >nsubj FamilytOe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] controller:Familyt/e1: ents2Label-mention-ngram: transformation bytHe2: trigger-arg-path: Positive_regulation >nn [lemma='tip60'] controllertie2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='tip60'] controller:Gene_or_gene_producttPe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] controllertLe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] FamilytPe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Familyt8e2: ents2Label-mention-ngram: and subsequent degradationt7e1: ents2Label-mention-ngram: induced transformation byt4e1: ents2Label-mention-ngram: subsequent degradationtWe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn controller:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='tip60'] controllertEe2: trigger-arg-path: acetylation >nn controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: acetylation andtGe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Familyt]e2: trigger-arg-path: Positive_regulation >nn [lemma='tip60'] controller:Gene_or_gene_producttWe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] controller:Familyt8e2: ents2Label-mention-ngram: acetylation and subsequentt?e1: trigger-arg-path: induced:Positive_regulation >nsubj Familyt;e1: args2Role-mention-ngram: transformation by facilitatingtjtrigger-to-trigger-path: e1:induced:Positive_regulation >prepc_by >dobj e2:acetylation:Positive_regulationt6e1: trigger-arg-path: induced >nsubj controller:Familyt>e1: args2Role-mention-ngram: CONTROLLER induced transformationt7e1: args2Role-mention-ngram: by facilitating CONTROLLEDt\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='brca1'] Gene_or_gene_productt_e1: trigger-arg-path: interacts:Binding >prep_with [lemma='eralpha'] theme:Gene_or_gene_producttDe1: trigger-arg-path: interacts:Binding >nsubj [lemma='brca1'] themetWe2: trigger-arg-path: represses >dobj [lemma='eralpha'] controlled:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='brca1'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='eralpha'] Gene_or_gene_producttSe1: trigger-arg-path: interacts:Binding >nsubj [lemma='brca1'] Gene_or_gene_productt`e2: trigger-arg-path: represses:Negative_activation >dobj [lemma='eralpha'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eralpha'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='brca1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='eralpha'] controlledtfe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='eralpha'] controlledtBe2: trigger-arg-path: represses >dobj [lemma='eralpha'] controlledt@e1: trigger-arg-path: Binding >prep_with [lemma='eralpha'] themetae2: trigger-arg-path: Negative_activation >dobj [lemma='eralpha'] controlled:Gene_or_gene_producttke2: trigger-arg-path: represses:Negative_activation >dobj [lemma='eralpha'] controlled:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eralpha'] Gene_or_gene_producttVe2: trigger-arg-path: represses:Negative_activation >dobj [lemma='eralpha'] controlledtnsubj [lemma='brca1'] themet[e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eralpha'] themethe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eralpha'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='brca1'] themetYe1: trigger-arg-path: interacts:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eralpha'] themet{e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='eralpha'] controlled:Gene_or_gene_producttQe1: trigger-arg-path: interacts >nsubj [lemma='brca1'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='brca1'] themetIe1: trigger-arg-path: Binding >nsubj [lemma='brca1'] Gene_or_gene_producttWe1: trigger-arg-path: interacts >prep_with [lemma='eralpha'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='eralpha'] controlled:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_with [lemma='eralpha'] Gene_or_gene_producttLe2: trigger-arg-path: Negative_activation >dobj [lemma='eralpha'] controlledtYe1: trigger-arg-path: interacts:Binding >prep_with [lemma='eralpha'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: interacts >prep_with [lemma='eralpha'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_with [lemma='eralpha'] theme:Gene_or_gene_producttLe2: trigger-arg-path: represses >dobj [lemma='eralpha'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interacts:Binding >prep_with [lemma='eralpha'] themet\e2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='eralpha'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eralpha'] Gene_or_gene_producttBe1: trigger-arg-path: interacts >prep_with [lemma='eralpha'] themetKe1: trigger-arg-path: interacts >nsubj [lemma='brca1'] Gene_or_gene_producttVe2: trigger-arg-path: Negative_activation >dobj [lemma='eralpha'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='brca1'] themet5e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL inducedtke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='glucose'] Simple_chemicaltWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='glucose'] Simple_chemicalt2e2: trigger-arg-path: induced >dobj >nn controlledtQe1: trigger-arg-path: Binding >prep_with [lemma='akt'] theme:Gene_or_gene_productt#interceding-token ngrams: effect ontKe2: trigger-arg-path: Positive_activation >nsubj controller:Simple_chemicalt1interceding-token ngrams: although their specifictTe1: trigger-arg-path: interact:Binding >nsubj [lemma='isoform'] Gene_or_gene_producttLe1: trigger-arg-path: interact >nsubj [lemma='isoform'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='isoform'] theme:Gene_or_gene_productt'interceding-token ngrams: has also beentke2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='glucose'] controller:Simple_chemicalt$interceding-token ngrams: is isoformt?trigger-to-trigger-path: e1:interact:Binding >parataxis [lemma='demonstrate'] >ccomp [lemma='induce'] e2:induced:Positive_activationt%interceding-token ngrams: dependent ;tve2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlled:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='isoform'] theme:Gene_or_gene_productt+interceding-token ngrams: demonstrated thatt-interceding-token ngrams: isoform dependent ;tKe1: trigger-arg-path: Binding >prep_with [lemma='akt'] Gene_or_gene_productt[e2: trigger-arg-path: induced:Positive_activation >dobj >nn controlled:Gene_or_gene_producttee2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='glucose'] controller:Simple_chemicalt)interceding-token ngrams: Akt activity ist@e2: trigger-arg-path: Positive_activation >nsubj Simple_chemicalt#interceding-token ngrams: that hight{e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='akt'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] Gene_or_gene_producttUe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='akt'] controlledt interceding-token ngrams: on Aktt^e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='isoform'] Gene_or_gene_productt&interceding-token ngrams: demonstratedtTe1: trigger-arg-path: interact:Binding >prep_with [lemma='akt'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj Simple_chemicalt?interceding-tokens-full-span: although their specific effect on Akt activity is isoform dependent ; it has also been demonstrated that hightle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='akt'] theme:Gene_or_gene_productt,interceding-token ngrams: specific effect ontLe1: trigger-arg-path: interact >prep_with [lemma='akt'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='akt'] theme:Gene_or_gene_producttje2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='akt'] controlled:Gene_or_gene_productt%interceding-token ngrams: activity istae2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn controlledt?shortest-path: parataxis [lemma='demonstrate'] >ccomp [lemma='induce'] >nsubj [lemma='glucose']tFe2: trigger-arg-path: induced >nsubj [lemma='glucose'] Simple_chemicaltHe2: trigger-arg-path: induced:Positive_activation >nsubj Simple_chemicaltfe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='akt'] controlledtinterceding-token ngrams: Aktt^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='akt'] Gene_or_gene_productt&interceding-token ngrams: Akt activitytze2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlledt/interceding-token ngrams: their specific effecttfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='isoform'] Gene_or_gene_productt)interceding-token ngrams: on Akt activityt~e2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlled:Gene_or_gene_producttQe2: trigger-arg-path: induced >nsubj [lemma='glucose'] controller:Simple_chemicalt0interceding-token ngrams: been demonstrated thatt+interceding-token ngrams: isoform dependentt2shortest-path: parataxis >ccomp >nsubjtZe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='glucose'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlled:Gene_or_gene_productt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interact withtae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn Gene_or_gene_productt interceding-token ngrams: it hast!interceding-token ngrams: isoformt"interceding-token ngrams: has alsotde2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Simple_chemicalt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interacttRe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='glucose'] controllertZe1: trigger-arg-path: interact:Binding >nsubj [lemma='isoform'] theme:Gene_or_gene_productt.interceding-token ngrams: is isoform dependenttMe2: trigger-arg-path: Positive_activation >nsubj [lemma='glucose'] controllertfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='akt'] Gene_or_gene_producttdobj >nn Gene_or_gene_productt"interceding-token ngrams: ; it hastEe1: trigger-arg-path: interact:Binding >nsubj [lemma='isoform'] themetbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='glucose'] controller:Simple_chemicaltZe1: trigger-arg-path: interact:Binding >prep_with [lemma='akt'] theme:Gene_or_gene_productt]e2: trigger-arg-path: Positive_activation >nsubj [lemma='glucose'] controller:Simple_chemicaltie2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] controlledt%interceding-token ngrams: it has alsotFe2: trigger-arg-path: induced:Positive_activation >dobj >nn controlledtRe1: trigger-arg-path: interact >nsubj [lemma='isoform'] theme:Gene_or_gene_producttnsubj [lemma='isoform'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: THEME interact withtSe2: trigger-arg-path: induced:Positive_activation >nsubj controller:Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn controlled:Gene_or_gene_productt(interceding-token ngrams: although theirtMe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn Gene_or_gene_producttinterceding-token ngrams: ; ittCe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn controlledtGe2: trigger-arg-path: induced >dobj >nn controlled:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn controlled:Gene_or_gene_producttEe1: trigger-arg-path: interact:Binding >prep_with [lemma='akt'] themet]trigger-to-trigger-path: e1:interact:Binding >parataxis >ccomp e2:induced:Positive_activationtWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='akt'] themetprep_with [lemma='akt'] themetfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='glucose'] controllert_e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='akt'] Gene_or_gene_productt#interceding-token ngrams: also beentAe2: trigger-arg-path: induced >nsubj [lemma='glucose'] controllert(interceding-token ngrams: their specifictKe1: trigger-arg-path: Binding >nsubj [lemma='isoform'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='akt'] themetpe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='akt'] Gene_or_gene_productt=e1: trigger-arg-path: interact >prep_with [lemma='akt'] themet+interceding-token ngrams: been demonstratedtRe2: trigger-arg-path: Positive_activation >nsubj [lemma='glucose'] Simple_chemicaltWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='isoform'] themetPe2: trigger-arg-path: induced:Positive_activation >dobj >nn Gene_or_gene_producttinterceding-token ngrams: hightOe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='isoform'] themetUe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='glucose'] controllertnsubj [lemma='isoform'] themet)interceding-token ngrams: specific effectt=e1: trigger-arg-path: interact >nsubj [lemma='isoform'] themetse2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='akt'] Gene_or_gene_productt0interceding-token ngrams: also been demonstratedt-interceding-token ngrams: activity is isoformtRe1: trigger-arg-path: interact >prep_with [lemma='akt'] theme:Gene_or_gene_productt(interceding-token ngrams: dependent ; itt0interceding-token ngrams: demonstrated that hight0e1: args2Role-mention-ngram: complex and promotet+e1: ents2Label-mention-ngram: to bridge thet"e2: args2Role-mention-ngram: othert1e2: ents2Label-mention-ngram: associate with eachtqe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controller:Gene_or_gene_producttYe1: trigger-arg-path: promote nsubj [lemma='asb2'] controllert,e2: args2Role-mention-ngram: with each othert+e1: args2Role-mention-ngram: Skp2 associatetfe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj Gene_or_gene_productt-e1: ents2Label-mention-ngram: with each othert0e1: ents2Label-mention-ngram: cullin5 containingt8e1: ents2Label-mention-ngram: the polyubiquitination andt$e1: ents2Label-mention-ngram: ligaset$e2: ents2Label-mention-ngram: bridget,e2: args2Role-mention-ngram: a non canonicalt'e1: args2Role-mention-ngram: bridge thet!e2: ents2Label-mention-ngram: nont]e1: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: bridget-e1: ents2Label-mention-ngram: SHARED and Skp2tge2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='asb2'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: to bridget?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='asb2'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: to bridget'e1: args2Role-mention-ngram: containingt/e1: args2Role-mention-ngram: ligase complex andt&e1: args2Role-mention-ngram: to bridget0e1: args2Role-mention-ngram: associate with eacht!e1: args2Role-mention-ngram: Skp2tze1: trigger-arg-path: Positive_regulation nsubj [lemma='asb2'] controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: associatet-e2: args2Role-mention-ngram: the formation oft$e1: args2Role-mention-ngram: promotet!e1: args2Role-mention-ngram: eacht\e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controllert,e2: args2Role-mention-ngram: and promote thet9e2: args2Role-mention-ngram: containing dimeric ubiquitintwe1: trigger-arg-path: promote:Positive_regulation nsubj [lemma='asb2'] Gene_or_gene_productt!e1: args2Role-mention-ngram: of at'e1: ents2Label-mention-ngram: canonicalt1e1: args2Role-mention-ngram: bridge the formationt(e1: ents2Label-mention-ngram: containingt(e1: args2Role-mention-ngram: promote thet.e1: ents2Label-mention-ngram: the formation oft-e1: ents2Label-mention-ngram: other to bridgetJe2: trigger-arg-path: associate >nsubj [lemma='asb2'] Gene_or_gene_productt(e2: args2Role-mention-ngram: and promotet1e2: ents2Label-mention-ngram: complex and promotetJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='asb2'] controllert*e1: ents2Label-mention-ngram: cullin1- andt%e2: ents2Label-mention-ngram: promotetpe2: trigger-arg-path: lemmatizedTrigger=associate:Positive_regulation >nsubj [lemma='asb2'] Gene_or_gene_productt5e2: args2Role-mention-ngram: dimeric ubiquitin ligaset)e1: ents2Label-mention-ngram: and promotet3e1: args2Role-mention-ngram: non canonical cullin1-t+e2: args2Role-mention-ngram: formation of at*e2: ents2Label-mention-ngram: cullin1- andt'e2: args2Role-mention-ngram: each othert/e1: args2Role-mention-ngram: and Skp2 associatet;e2: trigger-arg-path: associate >nsubj Gene_or_gene_productt+e1: args2Role-mention-ngram: associate witht0e2: args2Role-mention-ngram: CONTROLLER and Skp2t:e1: ents2Label-mention-ngram: containing dimeric ubiquitint1e2: trigger-arg-path: associate >nsubj controllert3e2: args2Role-mention-ngram: non canonical cullin1-t%e2: ents2Label-mention-ngram: dimerict1e2: ents2Label-mention-ngram: Skp2 associate witht/e1: ents2Label-mention-ngram: dimeric ubiquitint-e1: ents2Label-mention-ngram: a non canonicalt,e2: ents2Label-mention-ngram: formation of at'e1: ents2Label-mention-ngram: associatet)e2: args2Role-mention-ngram: formation oft*e1: args2Role-mention-ngram: the formationt*e2: args2Role-mention-ngram: the formationt8e2: ents2Label-mention-ngram: cullin5 containing dimerict.e2: ents2Label-mention-ngram: ubiquitin ligaset4e1: ents2Label-mention-ngram: non canonical cullin1-t0e2: ents2Label-mention-ngram: cullin5 containingt%e1: ents2Label-mention-ngram: promotet,e1: ents2Label-mention-ngram: ligase complext#e1: args2Role-mention-ngram: ligaset2e1: ents2Label-mention-ngram: cullin1- and cullin5t0e1: ents2Label-mention-ngram: ligase complex andt+e1: ents2Label-mention-ngram: each other tot0e1: args2Role-mention-ngram: Skp2 associate witht0e2: args2Role-mention-ngram: complex and promotet e1: args2Role-mention-ngram: nont%e2: args2Role-mention-ngram: cullin1-t-e1: ents2Label-mention-ngram: and promote thet@e1: ents2Label-mention-ngram: polyubiquitination and degradationt/e1: args2Role-mention-ngram: canonical cullin1-t#e2: args2Role-mention-ngram: bridget+e1: ents2Label-mention-ngram: non canonicalt/e2: args2Role-mention-ngram: cullin5 containingt?e1: trigger-arg-path: promote:Positive_regulation nsubj [lemma='asb2'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: each othertee1: trigger-arg-path: Positive_regulation nsubj [lemma='asb2'] controllert'e2: ents2Label-mention-ngram: ubiquitint$e2: args2Role-mention-ngram: promotet#e1: ents2Label-mention-ngram: a nontke1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='asb2'] controllert%e1: ents2Label-mention-ngram: dimerict"e1: args2Role-mention-ngram: a nontMe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj Gene_or_gene_productt.e2: args2Role-mention-ngram: dimeric ubiquitint$e1: args2Role-mention-ngram: dimerict0e2: args2Role-mention-ngram: associate with eacht e2: args2Role-mention-ngram: nontKe1: trigger-arg-path: promote nsubj controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: cullin1-t^e2: trigger-arg-path: associate:Positive_regulation >nsubj [lemma='asb2'] Gene_or_gene_productt-e1: args2Role-mention-ngram: the formation oft7e2: args2Role-mention-ngram: cullin5 containing dimerict8e2: ents2Label-mention-ngram: the polyubiquitination andt!e2: args2Role-mention-ngram: eacht%e2: args2Role-mention-ngram: other tot{e2: trigger-arg-path: lemmatizedTrigger=associate:Positive_regulation >nsubj [lemma='asb2'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: and cullin5t4e2: ents2Label-mention-ngram: canonical cullin1- andt&e2: args2Role-mention-ngram: with eacht&e1: args2Role-mention-ngram: with eacht1e2: args2Role-mention-ngram: bridge the formationt'e1: ents2Label-mention-ngram: to bridget0e1: ents2Label-mention-ngram: and Skp2 associatet(e1: args2Role-mention-ngram: and promotet,e1: ents2Label-mention-ngram: Skp2 associatet+e2: args2Role-mention-ngram: ligase complext'e2: ents2Label-mention-ngram: with eacht,e2: ents2Label-mention-ngram: ligase complext$e2: args2Role-mention-ngram: dimericte1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='asb2'] controllert4e1: ents2Label-mention-ngram: polyubiquitination andt!e2: args2Role-mention-ngram: Skp2tle2: trigger-arg-path: lemmatizedTrigger=associate:Positive_regulation >nsubj controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: cullin1- and cullin5t*e1: args2Role-mention-ngram: to bridge thet%e2: ents2Label-mention-ngram: cullin5t2e2: ents2Label-mention-ngram: bridge the formationt+e2: ents2Label-mention-ngram: the formationt3e1: args2Role-mention-ngram: promote the CONTROLLEDt&e1: ents2Label-mention-ngram: cullin1-t?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='asb2'] Gene_or_gene_productt3e1: args2Role-mention-ngram: and cullin5 containingtRe1: trigger-arg-path: lemmatizedTrigger=promote nsubj Gene_or_gene_productt6e1: ents2Label-mention-ngram: ubiquitin ligase complext)e1: args2Role-mention-ngram: formation oft(e2: args2Role-mention-ngram: and cullin5t/e1: args2Role-mention-ngram: containing dimerict0e1: ents2Label-mention-ngram: canonical cullin1-t!e2: args2Role-mention-ngram: of at3e2: args2Role-mention-ngram: and cullin5 containingt&e2: ents2Label-mention-ngram: cullin1-t-e2: args2Role-mention-ngram: ubiquitin ligaset_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='asb2'] controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: promote the CONTROLLEDt)e2: args2Role-mention-ngram: cullin1- andt"e2: args2Role-mention-ngram: a nont?e1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='asb2'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: dimeric ubiquitint*e2: args2Role-mention-ngram: to bridge thet_e1: trigger-arg-path: promote:Positive_regulation nsubj controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: ligase complex andt.e1: ents2Label-mention-ngram: ubiquitin ligaset0e2: args2Role-mention-ngram: Skp2 associate witht,e2: ents2Label-mention-ngram: Skp2 associatet&e1: args2Role-mention-ngram: ubiquitint'e1: args2Role-mention-ngram: each othert&e2: args2Role-mention-ngram: ubiquitint+e1: args2Role-mention-ngram: formation of atTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='asb2'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: and cullin5 containingt$e1: args2Role-mention-ngram: cullin5t&e2: ents2Label-mention-ngram: other totJe1: trigger-arg-path: promote:Positive_regulation nsubj controllert)e1: ents2Label-mention-ngram: complex andt5e1: args2Role-mention-ngram: ubiquitin ligase complext@e1: trigger-arg-path: promote nsubj Gene_or_gene_producttie2: trigger-arg-path: associate:Positive_regulation >nsubj [lemma='asb2'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED and Skp2t/e2: args2Role-mention-ngram: ligase complex andt(e1: ents2Label-mention-ngram: each othert7e1: args2Role-mention-ngram: cullin5 containing dimerict4e1: ents2Label-mention-ngram: the polyubiquitinationt,e1: ents2Label-mention-ngram: associate witht#e2: ents2Label-mention-ngram: a nont%e1: ents2Label-mention-ngram: cullin5tUe2: trigger-arg-path: associate >nsubj [lemma='asb2'] controller:Gene_or_gene_producttTe2: trigger-arg-path: associate:Positive_regulation >nsubj [lemma='asb2'] controllert"e1: ents2Label-mention-ngram: eacht:e2: ents2Label-mention-ngram: containing dimeric ubiquitint(e2: ents2Label-mention-ngram: bridge thet0e1: ents2Label-mention-ngram: polyubiquitinationtTe1: trigger-arg-path: promote:Positive_regulation nsubj Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj controllert0e1: ents2Label-mention-ngram: containing dimerict)e1: ents2Label-mention-ngram: and cullin5tnsubj [lemma='asb2'] controllert/e2: args2Role-mention-ngram: and Skp2 associatet'e2: args2Role-mention-ngram: bridge thet+e2: ents2Label-mention-ngram: to bridge thet)e1: args2Role-mention-ngram: cullin1- andtRe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='asb2'] controllertXe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj controller:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=promote nsubj controllert4e2: ents2Label-mention-ngram: non canonical cullin1-t"e1: ents2Label-mention-ngram: of at(e2: args2Role-mention-ngram: promote thet*e1: args2Role-mention-ngram: non canonicalt0e2: ents2Label-mention-ngram: canonical cullin1-t+e2: args2Role-mention-ngram: Skp2 associatet+e1: args2Role-mention-ngram: ligase complext%e1: args2Role-mention-ngram: other tot'e1: ents2Label-mention-ngram: with eacht3e1: args2Role-mention-ngram: canonical cullin1- andt-e2: ents2Label-mention-ngram: with each othert*e1: args2Role-mention-ngram: each other tot6e2: ents2Label-mention-ngram: ubiquitin ligase complexte1: trigger: promotet,e1: args2Role-mention-ngram: with each othert1e2: args2Role-mention-ngram: cullin1- and cullin5tZe2: trigger-arg-path: associate:Positive_regulation >nsubj controller:Gene_or_gene_productt_trigger-to-trigger-path: e1:promote:Positive_regulation nsubj controllert%e2: args2Role-mention-ngram: and Skp2t.e1: args2Role-mention-ngram: dimeric ubiquitint*e2: args2Role-mention-ngram: each other tot-e1: args2Role-mention-ngram: ubiquitin ligaset/e1: args2Role-mention-ngram: cullin5 containingt'e1: ents2Label-mention-ngram: ubiquitint9e1: args2Role-mention-ngram: containing dimeric ubiquitint#e1: ents2Label-mention-ngram: othert"e2: ents2Label-mention-ngram: Skp2t(e1: args2Role-mention-ngram: complex andt6e1: ents2Label-mention-ngram: dimeric ubiquitin ligasetfe2: trigger-arg-path: lemmatizedTrigger=associate:Positive_regulation >nsubj [lemma='asb2'] controllert&e1: args2Role-mention-ngram: canonicalt$e2: args2Role-mention-ngram: cullin5t,e1: args2Role-mention-ngram: other to bridget0e2: ents2Label-mention-ngram: and Skp2 associatetne1: trigger-arg-path: promote nsubj [lemma='asb2'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: canonicalt"e1: args2Role-mention-ngram: othertue1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='asb2'] Gene_or_gene_productt&e2: args2Role-mention-ngram: canonicalt-e2: ents2Label-mention-ngram: other to bridgetoe1: trigger-arg-path: Positive_regulation nsubj [lemma='asb2'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: polyubiquitination andt"e2: ents2Label-mention-ngram: eacht0e2: ents2Label-mention-ngram: containing dimerict-e2: ents2Label-mention-ngram: a non canonicaltnsubj controllert)e2: ents2Label-mention-ngram: and promotet%e1: args2Role-mention-ngram: and Skp2t,e2: ents2Label-mention-ngram: associate witht%e1: args2Role-mention-ngram: of a nont!e1: ents2Label-mention-ngram: nont(e1: ents2Label-mention-ngram: bridge thet&e2: args2Role-mention-ngram: associatet6e2: ents2Label-mention-ngram: dimeric ubiquitin ligaset)e1: ents2Label-mention-ngram: promote thet\e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='asb2'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: associatet@e2: trigger-arg-path: associate >nsubj [lemma='asb2'] controllert,e1: args2Role-mention-ngram: a non canonicaltEe2: trigger-arg-path: associate:Positive_regulation >nsubj controllert(e1: args2Role-mention-ngram: and cullin5t*e1: ents2Label-mention-ngram: formation oft3e2: args2Role-mention-ngram: canonical cullin1- andt+e2: args2Role-mention-ngram: associate witht.e2: ents2Label-mention-ngram: the formation oft"e2: ents2Label-mention-ngram: of at-e2: ents2Label-mention-ngram: and promote thet4e2: ents2Label-mention-ngram: and cullin5 containingt&e2: ents2Label-mention-ngram: and Skp2t2e2: ents2Label-mention-ngram: cullin1- and cullin5t&e1: ents2Label-mention-ngram: and Skp2t@e2: ents2Label-mention-ngram: polyubiquitination and degradationtae2: trigger-arg-path: lemmatizedTrigger=associate:Positive_regulation >nsubj Gene_or_gene_producttFe2: trigger-arg-path: associate >nsubj controller:Gene_or_gene_productte2: trigger: associatet5e1: args2Role-mention-ngram: dimeric ubiquitin ligaset+e2: ents2Label-mention-ngram: non canonicalt+e2: ents2Label-mention-ngram: each other tot&e2: ents2Label-mention-ngram: of a nontce1: trigger-arg-path: promote nsubj [lemma='asb2'] Gene_or_gene_productt,e1: args2Role-mention-ngram: and promote thet,e2: args2Role-mention-ngram: other to bridget5e2: args2Role-mention-ngram: ubiquitin ligase complextOe2: trigger-arg-path: associate:Positive_regulation >nsubj Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER and Skp2t&e1: ents2Label-mention-ngram: of a nont*e2: ents2Label-mention-ngram: formation oft1e1: ents2Label-mention-ngram: Skp2 associate witht/e2: args2Role-mention-ngram: containing dimerict&e2: args2Role-mention-ngram: 30 % witht'e2: ents2Label-mention-ngram: 30 % witht(e1: args2Role-mention-ngram: reduced thetNe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn Gene_or_gene_productt&e1: args2Role-mention-ngram: 30 % witht%e1: args2Role-mention-ngram: % with at9e1: args2Role-mention-ngram: CONTROLLER treatment reducedt,e2: ents2Label-mention-ngram: 416 in hypoxiatWe1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp [lemma='bind'] controlled:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: 416 in hypoxiat)e1: args2Role-mention-ngram: p-Src 416 intue2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='induction'] >prep_of [lemma='p-src'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: % reductiont&e1: ents2Label-mention-ngram: of p-Srct-e1: args2Role-mention-ngram: by approximatelytDe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn controllert-e2: args2Role-mention-ngram: approximately 30t_e1: trigger-arg-path: reduced >nsubj [lemma='treatment'] >nn [lemma='nac'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='nac'] controllertTe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp controlledt*e2: args2Role-mention-ngram: approximatelyt$e2: ents2Label-mention-ngram: of GTPt.e1: ents2Label-mention-ngram: approximately 30tne2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] themet6e1: ents2Label-mention-ngram: hypoxia by approximatelyt)e1: ents2Label-mention-ngram: concomitantt&e1: ents2Label-mention-ngram: % with at.e2: ents2Label-mention-ngram: reduction of GTPtbe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn Gene_or_gene_productt-e2: args2Role-mention-ngram: a concomitant 17t+e1: ents2Label-mention-ngram: the inductiont"e1: ents2Label-mention-ngram: 17 %tle2: trigger-arg-path: Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: p-Src 416t e1: ents2Label-mention-ngram: 17tOtrigger-to-trigger-path: e1:reduced:Negative_regulation >ccomp e2:bound:Bindingt&e2: ents2Label-mention-ngram: % with at,e1: ents2Label-mention-ngram: % reduction oftXe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn controllert0shortest-path: ccomp >nsubj >prep_oftCe1: trigger-arg-path: Negative_regulation >ccomp controlled:Bindingt)e1: args2Role-mention-ngram: of p-Src 416t.e1: ents2Label-mention-ngram: a concomitant 17t.e2: ents2Label-mention-ngram: GTP bound SHAREDt'e1: args2Role-mention-ngram: in hypoxiatve1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controller:Gene_or_gene_productt;e1: trigger-arg-path: reduced >ccomp [lemma='bind'] Bindingt8e1: trigger-arg-path: Negative_regulation >ccomp Bindingte1: args2Role-mention-ngram: 17t5e1: args2Role-mention-ngram: hypoxia by approximatelyt+e1: args2Role-mention-ngram: 17 % reductiont.e1: args2Role-mention-ngram: treatment reducedtse1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] Gene_or_gene_productt e2: ents2Label-mention-ngram: 17tJe1: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] controlledt*e1: ents2Label-mention-ngram: reduction oftde2: trigger-arg-path: bound >nsubj [lemma='induction'] >prep_of [lemma='p-src'] Gene_or_gene_productt)e2: args2Role-mention-ngram: of GTP boundt*e2: args2Role-mention-ngram: in hypoxia byt#e2: args2Role-mention-ngram: with at(e1: ents2Label-mention-ngram: in hypoxiat)e2: args2Role-mention-ngram: THEME 416 intOe1: trigger-arg-path: reduced:Negative_regulation >ccomp [lemma='bind'] Bindingtze1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controllert!e2: ents2Label-mention-ngram: 416t&e2: args2Role-mention-ngram: reductiont*e2: ents2Label-mention-ngram: reduction oft*e1: ents2Label-mention-ngram: p-Src 416 intme1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: approximatelyt"e2: ents2Label-mention-ngram: 17 %t)e1: ents2Label-mention-ngram: % reductiont'e2: ents2Label-mention-ngram: reductiont*e1: args2Role-mention-ngram: a concomitantt!e2: args2Role-mention-ngram: 30 %t&e1: args2Role-mention-ngram: reductiontke1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp [lemma='bind'] controlled:Bindingt(e2: args2Role-mention-ngram: % reductiont%e2: ents2Label-mention-ngram: hypoxiat;e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT boundt(e1: args2Role-mention-ngram: concomitantt*e2: args2Role-mention-ngram: a concomitanttWe2: trigger-arg-path: Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] themet$e1: ents2Label-mention-ngram: 416 int/e1: trigger-arg-path: reduced >ccomp controlledte2: args2Role-mention-ngram: 17t6e2: ents2Label-mention-ngram: hypoxia by approximatelyt.e2: ents2Label-mention-ngram: concomitant 17 %t,e1: ents2Label-mention-ngram: concomitant 17t+e1: args2Role-mention-ngram: 416 in hypoxiatQe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp BindingtUe2: trigger-arg-path: bound >nsubj [lemma='induction'] >prep_of [lemma='p-src'] themet#e2: args2Role-mention-ngram: of GTPt.e2: ents2Label-mention-ngram: by approximatelyt'e2: args2Role-mention-ngram: hypoxia byt-e1: args2Role-mention-ngram: approximately 30t/e1: args2Role-mention-ngram: with a concomitanttRe1: trigger-arg-path: reduced:Negative_regulation >ccomp [lemma='bind'] controlledt'e1: ents2Label-mention-ngram: 30 % witht1e1: ents2Label-mention-ngram: by approximately 30t5e2: args2Role-mention-ngram: hypoxia by approximatelyt-e1: args2Role-mention-ngram: a concomitant 17tpe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='nac'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: approximately 30 %t7e1: trigger-arg-path: reduced >ccomp controlled:Bindingt+e2: ents2Label-mention-ngram: in hypoxia bytGe1: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] Bindingt^trigger-to-trigger-path: e1:reduced:Negative_regulation >ccomp [lemma='bind'] e2:bound:Bindingt$e1: ents2Label-mention-ngram: % witht,e1: trigger-arg-path: reduced >ccomp Bindingt e2: args2Role-mention-ngram: 416t"e1: args2Role-mention-ngram: p-Srct/e1: args2Role-mention-ngram: approximately 30 %t]e2: trigger-arg-path: bound:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] themet+e2: args2Role-mention-ngram: % reduction oft-e2: args2Role-mention-ngram: reduction of GTPtie1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controllert e1: args2Role-mention-ngram: 416t,e2: ents2Label-mention-ngram: % reduction oft?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: hypoxia byt%e1: ents2Label-mention-ngram: hypoxiat$e1: args2Role-mention-ngram: hypoxiatHe1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp controlled:BindingtGe1: trigger-arg-path: reduced:Negative_regulation >nsubj >nn controllerte1: incoming: ccomp controlled:Bindingt(e1: args2Role-mention-ngram: % reductiont$e2: args2Role-mention-ngram: hypoxiatFe1: trigger-arg-path: reduced >ccomp [lemma='bind'] controlled:Bindingt0e1: ents2Label-mention-ngram: with a concomitantt"e1: ents2Label-mention-ngram: 30 %t-e2: args2Role-mention-ngram: concomitant 17 %te2: args2Role-mention-ngram: %t)e2: args2Role-mention-ngram: reduction oft+e2: ents2Label-mention-ngram: a concomitantt?e1: ents2Label-mention-ngram: reduction of GENE_OR_GENE_PRODUCTt*e1: args2Role-mention-ngram: the inductiont}e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp [lemma='bind'] Bindingt$e2: ents2Label-mention-ngram: 416 int*e1: ents2Label-mention-ngram: of p-Src 416t~e1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controller:Gene_or_gene_productt>e1: trigger-arg-path: reduced >ccomp [lemma='bind'] controlledt.e1: ents2Label-mention-ngram: concomitant 17 %t,e1: ents2Label-mention-ngram: 17 % reductiont#e1: ents2Label-mention-ngram: p-Srct#e1: args2Role-mention-ngram: 416 int?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] theme:Gene_or_gene_productt3e1: trigger-arg-path: reduced >nsubj >nn controllert'e1: ents2Label-mention-ngram: reductiontOe1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp [lemma='bind'] controlledt{e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='nac'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: approximatelyte1: ents2Label-mention-ngram: %tLe1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp [lemma='bind'] BindingtCe1: trigger-arg-path: reduced:Negative_regulation >ccomp controlledt.e2: ents2Label-mention-ngram: approximately 30t3e1: ents2Label-mention-ngram: reduced the inductiont/e1: ents2Label-mention-ngram: treatment reducedt=e1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp Bindingt#e1: args2Role-mention-ngram: % witht/e2: args2Role-mention-ngram: with a concomitanttae1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] controllert,e2: ents2Label-mention-ngram: concomitant 17t2e1: args2Role-mention-ngram: treatment reduced thet1e2: ents2Label-mention-ngram: by approximately 30t+e2: args2Role-mention-ngram: concomitant 17tre2: trigger-arg-path: bound:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: hypoxia byt$e2: ents2Label-mention-ngram: % witht?shortest-path: ccomp [lemma='bind'] >nsubj [lemma='induction'] >prep_of [lemma='p-src']t$e1: ents2Label-mention-ngram: with at0e1: args2Role-mention-ngram: by approximately 30t/e2: args2Role-mention-ngram: approximately 30 %t(e1: ents2Label-mention-ngram: hypoxia byt4e1: args2Role-mention-ngram: reduction of CONTROLLEDt e1: ents2Label-mention-ngram: 30t,e1: ents2Label-mention-ngram: 416 in hypoxiat-e2: args2Role-mention-ngram: by approximatelyt\e1: trigger-arg-path: reduced:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: the induction oft"e2: ents2Label-mention-ngram: 30 %t!e1: args2Role-mention-ngram: 17 %t3e1: ents2Label-mention-ngram: treatment reduced thetje1: trigger-arg-path: reduced >nsubj [lemma='treatment'] >nn [lemma='nac'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: in hypoxia byte2: ents2Label-mention-ngram: %t)e1: ents2Label-mention-ngram: reduced thetHe1: trigger-arg-path: reduced >nsubj >nn controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: with a concomitantt&e1: args2Role-mention-ngram: p-Src 416t+e1: args2Role-mention-ngram: % reduction oft2e1: args2Role-mention-ngram: reduced the inductiont{e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='induction'] >prep_of [lemma='p-src'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: in hypoxiat/e1: args2Role-mention-ngram: induction of p-Srct.e1: ents2Label-mention-ngram: by approximatelyt*e2: ents2Label-mention-ngram: of GTP boundt)e1: args2Role-mention-ngram: reduction oft0e1: ents2Label-mention-ngram: induction of p-Srct6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 416tle2: trigger-arg-path: bound:Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: approximately 30 %t'e2: args2Role-mention-ngram: in hypoxiat@e1: trigger-arg-path: lemmatizedTrigger=reduce >ccomp controlledt-e1: args2Role-mention-ngram: concomitant 17 %t*e1: args2Role-mention-ngram: approximatelyte1: args2Role-mention-ngram: 30tYe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: a concomitantt e2: ents2Label-mention-ngram: 30t!e2: args2Role-mention-ngram: 17 %t)e2: ents2Label-mention-ngram: concomitantt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 416 int#e2: args2Role-mention-ngram: 416 intke1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='nac'] Gene_or_gene_productte2: incoming: nsubj [lemma='induction'] >prep_of [lemma='p-src'] theme:Gene_or_gene_productt!e1: ents2Label-mention-ngram: 416t#e2: args2Role-mention-ngram: % witht(e2: args2Role-mention-ngram: concomitanttDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT treatment reducedte1: args2Role-mention-ngram: %t,e2: ents2Label-mention-ngram: 17 % reductiontnsubj [lemma='treatment'] >nn [lemma='nac'] controllert%e2: args2Role-mention-ngram: % with at%e1: args2Role-mention-ngram: of p-Srct@e1: trigger-arg-path: reduced:Negative_regulation >ccomp BindingtZe1: trigger-arg-path: reduced:Negative_regulation >ccomp [lemma='bind'] controlled:Bindingt+e1: args2Role-mention-ngram: concomitant 17tfe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='induction'] >prep_of [lemma='p-src'] themet*e1: args2Role-mention-ngram: in hypoxia byte2: args2Role-mention-ngram: 30t$e2: ents2Label-mention-ngram: with atfe2: trigger-arg-path: Binding >nsubj [lemma='induction'] >prep_of [lemma='p-src'] Gene_or_gene_producttQe1: trigger-arg-path: reduced:Negative_regulation >nsubj >nn Gene_or_gene_productt!e1: args2Role-mention-ngram: 30 %t#e1: args2Role-mention-ngram: with atce1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp [lemma='bind'] controlledt,e2: args2Role-mention-ngram: GTP bound THEMEt0e2: args2Role-mention-ngram: by approximately 30t\e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >ccomp controlled:Bindingt&e2: args2Role-mention-ngram: THEME 416tRe1: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] controlled:Bindingt=e1: trigger-arg-path: reduced >nsubj >nn Gene_or_gene_productt-e1: args2Role-mention-ngram: the induction oft7e2: ents2Label-mention-ngram: induced SHARED activationt/e2: ents2Label-mention-ngram: activation , CHK1t7e2: ents2Label-mention-ngram: CHK1 S345 phosphorylationt1e2: ents2Label-mention-ngram: SHARED activation ,t!e2: ents2Label-mention-ngram: S15t5e2: ents2Label-mention-ngram: p53 S15 phosphorylationt3e2: ents2Label-mention-ngram: phosphorylation , p53t]e2: trigger-arg-path: Positive_regulation >nsubj [lemma='HU'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: ERK2 reducedt/e1: ents2Label-mention-ngram: SHARED activationt5e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ortle1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controllert,e1: args2Role-mention-ngram: or ERK2 reducedtge1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controllert/e2: ents2Label-mention-ngram: phosphorylation ,t7e1: ents2Label-mention-ngram: induced SHARED activationt%e2: ents2Label-mention-ngram: p53 S15t)e1: ents2Label-mention-ngram: , CHK1 S345t|e1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controller:Gene_or_gene_producttoe1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controllert*e1: ents2Label-mention-ngram: activation ,t7e1: ents2Label-mention-ngram: CHK1 S345 phosphorylationtPe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='HU'] controllert'e1: ents2Label-mention-ngram: CHK1 S345t/e1: args2Role-mention-ngram: CONTROLLER or ERK2t?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: activation ,tRe2: trigger-arg-path: Positive_regulation >nsubj [lemma='HU'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] Gene_or_gene_productt!e1: args2Role-mention-ngram: ERK2t?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controllertWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='HU'] Gene_or_gene_productt]trigger-to-trigger-path: e1:reduced:Positive_regulation >ccomp e2:induced:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controller:Gene_or_gene_producttoshortest-path: ccomp [lemma='induce'] >nsubj [lemma='HU']tHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='HU'] controllert2e2: ents2Label-mention-ngram: S345 phosphorylationtke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='HU'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: CHK1tqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: activation , CHK1t1e2: ents2Label-mention-ngram: S15 phosphorylationtpe1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: S345tve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='HU'] controller:Gene_or_gene_producttnsubj [lemma='HU'] controllert4e2: ents2Label-mention-ngram: S345 phosphorylation ,t"e2: ents2Label-mention-ngram: CHK1t-e1: ents2Label-mention-ngram: or ERK2 reducedt'e2: ents2Label-mention-ngram: , p53 S15tntrigger-to-trigger-path: e1:reduced:Positive_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationtee2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='HU'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: SHARED activationtQe2: trigger-arg-path: induced >nsubj [lemma='HU'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: CONTROLLER ort"e1: ents2Label-mention-ngram: ERK2t4e1: ents2Label-mention-ngram: reduced SHARED inducedt%e1: ents2Label-mention-ngram: or ERK2t"e2: ents2Label-mention-ngram: S345t?e1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: , CHK1t2e1: ents2Label-mention-ngram: S345 phosphorylationt1e1: ents2Label-mention-ngram: ERK2 reduced SHAREDt$e1: args2Role-mention-ngram: or ERK2tMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='HU'] controllert1e1: ents2Label-mention-ngram: SHARED activation ,tFe2: trigger-arg-path: induced >nsubj [lemma='HU'] Gene_or_gene_producttye1: trigger-arg-path: reduced:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] Gene_or_gene_producttee1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] Gene_or_gene_productt4e1: args2Role-mention-ngram: ERK2 reduced CONTROLLEDt$e2: ents2Label-mention-ngram: , CHK1t[e1: trigger-arg-path: reduced >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controllert#e2: ents2Label-mention-ngram: , p53t)e1: args2Role-mention-ngram: ERK2 reducedt'e2: ents2Label-mention-ngram: CHK1 S345t?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='erk1'] controller:Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT or ERK2t)e2: ents2Label-mention-ngram: , CHK1 S345tae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='HU'] controllertZe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='HU'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='HU'] controller:Gene_or_gene_producttIe1: trigger-arg-path: mediates >nsubj [lemma='mapk'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: the phosphorylation oft1e2: ents2Label-mention-ngram: SHARED mediates thet_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: mediates the CONTROLLEDt0e2: trigger-arg-path: mediates >nsubj controllertDe1: trigger-arg-path: mediates:Positive_regulation >nsubj controllert%e2: args2Role-mention-ngram: mediatestne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] controllertEe2: trigger-arg-path: mediates >nsubj controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: serine 112tye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: of SHARED ont*e1: ents2Label-mention-ngram: mediates thet:e1: ents2Label-mention-ngram: mediates the phosphorylationt%e1: args2Role-mention-ngram: mediatest-e1: ents2Label-mention-ngram: SHARED mediatest*e2: ents2Label-mention-ngram: of SHARED ontDe2: trigger-arg-path: mediates:Positive_regulation >nsubj controllertee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] controller:Gene_or_gene_productte2: trigger: mediatest0e1: args2Role-mention-ngram: CONTROLLER mediatest&e1: ents2Label-mention-ngram: mediatest'e1: ents2Label-mention-ngram: on serinet*e2: ents2Label-mention-ngram: mediates thet&e2: ents2Label-mention-ngram: mediatest:e1: trigger-arg-path: mediates >nsubj Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED on serinetJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] controllert+e2: ents2Label-mention-ngram: on serine 112t!e1: ents2Label-mention-ngram: 112tSe2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] controllert(e1: ents2Label-mention-ngram: serine 112tZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] Gene_or_gene_productt4e1: args2Role-mention-ngram: mediates the CONTROLLEDt4e2: args2Role-mention-ngram: CONTROLLER mediates thet:e2: ents2Label-mention-ngram: mediates the phosphorylationt!e2: ents2Label-mention-ngram: 112tde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] controllert0e2: args2Role-mention-ngram: CONTROLLER mediatestIe2: trigger-arg-path: mediates >nsubj [lemma='mapk'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] controllert)e2: args2Role-mention-ngram: mediates thete1: trigger: mediatest]e2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] controllert]e1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_producttEe1: trigger-arg-path: mediates >nsubj controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: on serine 112t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: mediates >nsubj [lemma='mapk'] controllertde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] controllertee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mapk'] Gene_or_gene_productthe2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_productt:e2: trigger-arg-path: mediates >nsubj Gene_or_gene_productt4e1: args2Role-mention-ngram: CONTROLLER mediates thetNe1: trigger-arg-path: mediates:Positive_regulation >nsubj Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_productt0e1: trigger-arg-path: mediates >nsubj controllert1e1: ents2Label-mention-ngram: SHARED mediates thetYe1: trigger-arg-path: mediates:Positive_regulation >nsubj controller:Gene_or_gene_producttYe2: trigger-arg-path: mediates:Positive_regulation >nsubj controller:Gene_or_gene_producttSe1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] controllert.e2: ents2Label-mention-ngram: SHARED on serinet-e2: ents2Label-mention-ngram: SHARED mediatesthe1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_producttTe1: trigger-arg-path: mediates >nsubj [lemma='mapk'] controller:Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_productt?e2: trigger-arg-path: mediates >nsubj [lemma='mapk'] controllertTe2: trigger-arg-path: mediates >nsubj [lemma='mapk'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: the phosphorylationtNe2: trigger-arg-path: mediates:Positive_regulation >nsubj Gene_or_gene_productt'e2: ents2Label-mention-ngram: on serinet)e1: args2Role-mention-ngram: mediates thetEe1: trigger-arg-path: bound >nsubj [lemma='gdp'] Gene_or_gene_producttinterceding-token ngrams: RAG-Ct6e1: trigger-arg-path: bound >nsubj [lemma='gdp'] themetBe2: trigger-arg-path: lemmatizedTrigger=activate >agent controllert!interceding-token ngrams: recruittGe1: trigger-arg-path: Binding >nsubj [lemma='gdp'] Gene_or_gene_producttZe2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='it'] Generic_entityte1: ents2Label-mention-ngram: Bt/e2: ents2Label-mention-ngram: GENERIC_ENTITY istGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gdp'] themet-e2: ents2Label-mention-ngram: is activated byt5e2: trigger-arg-path: activated >nsubjpass controlledtinterceding-token ngrams: ) cantMe1: trigger-arg-path: bound:Binding >nsubj [lemma='gdp'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rag-a'] themet"interceding-token ngrams: can thentPe2: trigger-arg-path: Positive_activation >nsubjpass [lemma='it'] Generic_entityt*interceding-token ngrams: can then recruitt,e1: args2Role-mention-ngram: and THEME boundtFe2: trigger-arg-path: activated >nsubjpass [lemma='it'] Generic_entityt e1: args2Role-mention-ngram: B )tOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gdp'] themetIe2: trigger-arg-path: activated:Positive_activation >nsubjpass controlledt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gdp'] theme:Gene_or_gene_productt^e2: trigger-arg-path: activated:Positive_activation >agent [lemma='rheb'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass controlled:Generic_entityt8e1: ents2Label-mention-ngram: ) and GENE_OR_GENE_PRODUCTt#e1: args2Role-mention-ngram: or B )tJe2: trigger-arg-path: activated >agent [lemma='rheb'] Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >agent [lemma='rheb'] controller:Gene_or_gene_producttFe2: trigger-arg-path: activated >agent controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='rheb'] controller:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass controlledt4e2: args2Role-mention-ngram: CONTROLLED is activatedt,e2: args2Role-mention-ngram: is activated bytee2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='it'] controlled:Generic_entityt/interceding-token ngrams: the lysosome membranet9e2: ents2Label-mention-ngram: GENERIC_ENTITY is activatedt(e1: args2Role-mention-ngram: ) and THEMEtbe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='it'] controlled:Generic_entityt9e2: trigger-arg-path: activated >nsubjpass Generic_entitytZe2: trigger-arg-path: activated:Positive_activation >agent controller:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='gdp'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gdp'] theme:Gene_or_gene_producttVe2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='it'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass Generic_entityt*e2: ents2Label-mention-ngram: is activatedtXe2: trigger-arg-path: activated:Positive_activation >nsubjpass controlled:Generic_entitytOe1: trigger-arg-path: Binding >nsubj [lemma='rag-a'] theme:Gene_or_gene_producttMe1: trigger-arg-path: bound >nsubj [lemma='rag-a'] theme:Gene_or_gene_producttEe2: trigger-arg-path: activated:Positive_activation >agent controllertVe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent controllert$interceding-token ngrams: RAG-C ( ort!interceding-token ngrams: D ) cant&interceding-token ngrams: the lysosomet#interceding-token ngrams: mTORC1 tote1: args2Role-mention-ngram: Btinterceding-token ngrams: DtZe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass controlledt?e2: ents2Label-mention-ngram: activated by GENE_OR_GENE_PRODUCTt;e2: trigger-arg-path: activated >agent Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass Generic_entitytinterceding-token ngrams: or DtUe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass controlled:Generic_entitytSe1: trigger-arg-path: bound:Binding >nsubj [lemma='gdp'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: ( ortGe1: trigger-arg-path: bound >nsubj [lemma='rag-a'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gdp'] Gene_or_gene_productte1: incoming: agent [lemma='rheb'] controller:Gene_or_gene_productt8e1: trigger-arg-path: bound >nsubj [lemma='rag-a'] themetke2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='it'] Generic_entitytge2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='it'] controlledtDe2: trigger-arg-path: activated >nsubjpass controlled:Generic_entityt?shortest-path: ccomp [lemma='recruit'] >prep_to [lemma='membrane'] >rcmod [lemma='activate'] >nsubjpass [lemma='it']t&interceding-token ngrams: then recruitt$e1: ents2Label-mention-ngram: ( or Btee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='rheb'] controllertLe2: trigger-arg-path: lemmatizedTrigger=activate >agent Gene_or_gene_productt$interceding-token ngrams: ) can thentBe2: trigger-arg-path: activated >nsubjpass [lemma='it'] controlledt@e2: trigger-arg-path: activated >agent [lemma='rheb'] controllert4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT (tXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rag-a'] Gene_or_gene_productt interceding-token ngrams: mTORC1t interceding-token ngrams: ( or Dt[e2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='rheb'] Gene_or_gene_productt@e1: trigger-arg-path: bound:Binding >nsubj [lemma='rag-a'] themet[e2: trigger-arg-path: Positive_activation >nsubjpass [lemma='it'] controlled:Generic_entityt?trigger-to-trigger-path: e1:bound:Binding >ccomp [lemma='recruit'] >prep_to [lemma='membrane'] >rcmod [lemma='activate'] e2:activated:Positive_activationt)interceding-token ngrams: to the lysosomet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rag-a'] Gene_or_gene_productt!e1: args2Role-mention-ngram: or BtOe2: trigger-arg-path: activated:Positive_activation >agent Gene_or_gene_productt+interceding-token ngrams: recruit mTORC1 totfe2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='rheb'] controller:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='rag-a'] themetOe1: trigger-arg-path: bound:Binding >nsubj [lemma='rag-a'] Gene_or_gene_producttatrigger-to-trigger-path: e1:bound:Binding >ccomp >prep_to >rcmod e2:activated:Positive_activationt!interceding-token ngrams: RAG-C (tLe2: trigger-arg-path: Positive_activation >nsubjpass [lemma='it'] controlledt?e2: trigger-arg-path: Positive_activation >nsubjpass controlledtWe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='it'] Generic_entitytMe2: trigger-arg-path: activated:Positive_activation >nsubjpass Generic_entityt$e1: args2Role-mention-ngram: B ) andtWe2: trigger-arg-path: lemmatizedTrigger=activate >agent controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: B ) andtJe2: trigger-arg-path: Positive_activation >agent [lemma='rheb'] controllertve2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='it'] controlled:Generic_entityt#e1: args2Role-mention-ngram: ( or Btoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='rheb'] Gene_or_gene_productt)e2: args2Role-mention-ngram: is activatedt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( ortUe1: trigger-arg-path: bound:Binding >nsubj [lemma='rag-a'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: THEME ( ort"interceding-token ngrams: lysosomet-interceding-token ngrams: then recruit mTORC1t!e1: ents2Label-mention-ngram: B )t"e1: ents2Label-mention-ngram: ( ortNe2: trigger-arg-path: Positive_activation >nsubjpass controlled:Generic_entityt>e1: trigger-arg-path: bound:Binding >nsubj [lemma='gdp'] themetSe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='it'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gdp'] Gene_or_gene_producttinterceding-token ngrams: D )tIe1: trigger-arg-path: Binding >nsubj [lemma='rag-a'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rag-a'] theme:Gene_or_gene_producttTe2: trigger-arg-path: Positive_activation >agent [lemma='rheb'] Gene_or_gene_producttCe2: trigger-arg-path: Positive_activation >nsubjpass Generic_entityt`e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent Gene_or_gene_productt"e1: ents2Label-mention-ngram: or BtKe1: trigger-arg-path: bound >nsubj [lemma='gdp'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: or B )tIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rag-a'] themetUe2: trigger-arg-path: activated >agent [lemma='rheb'] controller:Gene_or_gene_productt'interceding-token ngrams: mTORC1 to thetcinterceding-tokens-full-span: RAG-C ( or D ) can then recruit mTORC1 to the lysosome membrane wheret8e1: trigger-arg-path: Binding >nsubj [lemma='gdp'] themet+interceding-token ngrams: lysosome membranet interceding-token ngrams: or D )tQe2: trigger-arg-path: activated >nsubjpass [lemma='it'] controlled:Generic_entityt1e2: trigger-arg-path: activated >agent controllert(interceding-token ngrams: recruit mTORC1t1interceding-token ngrams: lysosome membrane wheretinterceding-token ngrams: ( ortQe2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='rheb'] controllertTe2: trigger-arg-path: activated:Positive_activation >agent [lemma='rheb'] controllertccomp >prep_to >rcmod >nsubjpasst^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rag-a'] theme:Gene_or_gene_producttfe2: trigger-arg-path: Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlledtre1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: inhibit CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] theme:Gene_or_gene_producttKe1: trigger-arg-path: bind:Binding >dobj [lemma='p53'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] themet&e1: args2Role-mention-ngram: or Mdm4 )tce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p53'] theme:Gene_or_gene_producttEe1: trigger-arg-path: bind >nsubj >prep_of theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: similarly bind SHAREDt!e1: args2Role-mention-ngram: Mdm4tle2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] controlledte2: incoming: dobj [lemma='p53'] themetde2: trigger-arg-path: inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: MdmX ( ort+e2: ents2Label-mention-ngram: SHARED , MdmXt&e1: args2Role-mention-ngram: MdmX ( ort(e2: args2Role-mention-ngram: and inhibitt3e2: ents2Label-mention-ngram: similarly bind SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttce1: trigger-arg-path: Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: or Mdm4 )t0e2: ents2Label-mention-ngram: can similarly bindt-e2: ents2Label-mention-ngram: , can similarlyt%e1: args2Role-mention-ngram: Mdm4 ) ,t?e2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt3e2: args2Role-mention-ngram: and inhibit CONTROLLEDtpe2: trigger-arg-path: Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] Gene_or_gene_productt1e1: args2Role-mention-ngram: similarly bind THEMEt,e1: ents2Label-mention-ngram: similarly bindt&e1: ents2Label-mention-ngram: Mdm4 ) ,t&e2: ents2Label-mention-ngram: Mdm4 ) ,tce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] themet0e2: ents2Label-mention-ngram: SHARED and inhibitt$e2: args2Role-mention-ngram: inhibitt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: ( or Mdm4t#e1: ents2Label-mention-ngram: , cant{e2: trigger-arg-path: Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttIe1: trigger-arg-path: bind >dobj [lemma='p53'] theme:Gene_or_gene_productte2: trigger: inhibitt"e1: args2Role-mention-ngram: , cantze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] Gene_or_gene_productt%e1: args2Role-mention-ngram: , MdmX (tne1: trigger-arg-path: bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: can similarlyt&e2: ents2Label-mention-ngram: , MdmX (t+e1: ents2Label-mention-ngram: SHARED , MdmXtZe2: trigger-arg-path: inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] controlledtQtrigger-to-trigger-path: e1:bind:Binding >conj_and e2:inhibit:Negative_activationt-e2: ents2Label-mention-ngram: bind SHARED andtGe1: trigger-arg-path: bind:Binding >nsubj >prep_of Gene_or_gene_producttGe2: trigger-arg-path: inhibit >dobj >nn controlled:Gene_or_gene_productt%e2: ents2Label-mention-ngram: or Mdm4t'e1: ents2Label-mention-ngram: MdmX ( ort&e1: ents2Label-mention-ngram: , MdmX (t,e2: ents2Label-mention-ngram: inhibit SHAREDt&e1: args2Role-mention-ngram: similarlyt-e1: ents2Label-mention-ngram: , can similarlyt&e1: args2Role-mention-ngram: ( or Mdm4t%e2: ents2Label-mention-ngram: ) , cant"e1: ents2Label-mention-ngram: Mdm4t"e1: ents2Label-mention-ngram: MdmXtme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlled:Gene_or_gene_producttoe2: trigger-arg-path: inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p53'] themetdobj >nn Gene_or_gene_producttCe1: trigger-arg-path: bind >dobj [lemma='p53'] Gene_or_gene_producttfe1: trigger-arg-path: bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: similarlyt%e1: ents2Label-mention-ngram: or Mdm4t$e1: ents2Label-mention-ngram: Mdm4 )tFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p53'] themet$e1: args2Role-mention-ngram: or Mdm4t,e2: ents2Label-mention-ngram: similarly bindtPe2: trigger-arg-path: inhibit:Negative_activation >dobj >nn Gene_or_gene_producttne2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlledtdobj [lemma='p53'] themetFe1: trigger-arg-path: Binding >dobj [lemma='p53'] Gene_or_gene_productt$e1: args2Role-mention-ngram: ) , cant0e1: trigger-arg-path: bind >nsubj >prep_of themetie1: trigger-arg-path: Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: ( or Mdm4t+e2: ents2Label-mention-ngram: can similarlyt$e1: ents2Label-mention-ngram: , MdmXt0e2: ents2Label-mention-ngram: and inhibit SHAREDtXe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlledtQe1: trigger-arg-path: bind:Binding >dobj [lemma='p53'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p53'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: Mdm4tve2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='transactivation'] >nn [lemma='p53'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: MdmXt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p53'] Gene_or_gene_productt/e1: args2Role-mention-ngram: can similarly bindtUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p53'] Gene_or_gene_productt[e2: trigger-arg-path: inhibit:Negative_activation >dobj >nn controlled:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlled:Gene_or_gene_productt$e1: ents2Label-mention-ngram: MdmX (t)e1: args2Role-mention-ngram: THEME , MdmXtYe1: trigger-arg-path: bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] themet0e1: ents2Label-mention-ngram: can similarly bindt#e1: args2Role-mention-ngram: Mdm4 )t8e1: trigger-arg-path: bind:Binding >nsubj >prep_of themet$e2: ents2Label-mention-ngram: Mdm4 )tQe1: trigger-arg-path: bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] themet%e1: ents2Label-mention-ngram: ) , cant?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: similarlytNe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn Gene_or_gene_producttLe1: trigger-arg-path: Binding >dobj [lemma='p53'] theme:Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLER and inhibitt+e1: args2Role-mention-ngram: similarly bindt?e1: trigger-arg-path: bind >nsubj >prep_of Gene_or_gene_productt$e2: ents2Label-mention-ngram: , MdmXt#e1: args2Role-mention-ngram: , MdmXt'e2: ents2Label-mention-ngram: or Mdm4 )txe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] Gene_or_gene_productt!e1: args2Role-mention-ngram: MdmXt2e2: trigger-arg-path: inhibit >dobj >nn controlledt+e1: ents2Label-mention-ngram: can similarlytDe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlledthe1: trigger-arg-path: bind:Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] Gene_or_gene_producttFe2: trigger-arg-path: inhibit:Negative_activation >dobj >nn controlledt`e1: trigger-arg-path: bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='transactivation'] >nn [lemma='p53'] controlledt#e1: args2Role-mention-ngram: MdmX (t,e1: args2Role-mention-ngram: , can similarlytxe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] theme:Gene_or_gene_producttctrigger-to-trigger-path: e1:bind:Binding >conj_and [lemma='inhibit'] e2:inhibit:Negative_activationt4e1: trigger-arg-path: bind >dobj [lemma='p53'] themet"e2: ents2Label-mention-ngram: ( ort$e2: ents2Label-mention-ngram: MdmX (tMe1: trigger-arg-path: bind:Binding >nsubj >prep_of theme:Gene_or_gene_producttTe1: trigger-arg-path: Binding >nsubj [lemma='homolog'] >prep_of [lemma='mdm2'] themetfshortest-path: parataxis [lemma='ubiquitinate'] >nsubjpass [lemma='beclin']t0e1: trigger-arg-path: bound:Binding >agent themet9e1: trigger-arg-path: Binding >agent [lemma='wash'] themet&e1: ents2Label-mention-ngram: is boundt/shortest-path: parataxis >nsubjpasstHe1: trigger-arg-path: Binding >agent [lemma='wash'] Gene_or_gene_productt1interceding-token ngrams: macrophages recognizingt interceding-token ngrams: f ) IntUe2: trigger-arg-path: Positive_regulation >agent [lemma='traf6'] Gene_or_gene_producttEe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='Beclin'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='wash'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: by the RING-typetinterceding-token ngrams: ftTe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='Beclin'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass Gene_or_gene_productt2e2: ents2Label-mention-ngram: ubiquitinated by thet)e2: ents2Label-mention-ngram: SHARED 1 ist1e2: args2Role-mention-ngram: the RING-type ligasetYe2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='traf6'] controllertZe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='Beclin'] theme:Gene_or_gene_producttinterceding-token ngrams: ; (tOe2: trigger-arg-path: ubiquitinated >agent [lemma='traf6'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: 1 iste2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='traf6'] controller:Gene_or_gene_producttIe1: trigger-arg-path: bound:Binding >nsubjpass theme:Gene_or_gene_productt1e2: ents2Label-mention-ngram: is ubiquitinated byt)interceding-token ngrams: recognizing LPSt-e2: args2Role-mention-ngram: RING-type ligasetEe2: trigger-arg-path: ubiquitinated >agent [lemma='traf6'] controllertVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent theme:Gene_or_gene_producttinterceding-token ngrams: LPS ,t`e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='traf6'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent Gene_or_gene_productt$e1: args2Role-mention-ngram: THEME 1tne2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='traf6'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='Beclin'] Gene_or_gene_productt%e1: args2Role-mention-ngram: bound bytAe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent themet7e1: trigger-arg-path: bound >agent Gene_or_gene_producttce2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='traf6'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass Gene_or_gene_producttTe1: trigger-arg-path: bound:Binding >agent [lemma='wash'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent controllert%interceding-token ngrams: recognizingtKe2: trigger-arg-path: Positive_regulation >agent [lemma='traf6'] controllert"e2: ents2Label-mention-ngram: 1 istFe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent controllertNe1: trigger-arg-path: lemmatizedTrigger=bind >agent theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='wash'] themet.e2: ents2Label-mention-ngram: ubiquitinated byt2e2: ents2Label-mention-ngram: the RING-type ligaset]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='Beclin'] Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass themet(e1: trigger-arg-path: bound >agent themetinterceding-token ngrams: ; ( ftinterceding-token ngrams: f )t&e1: ents2Label-mention-ngram: bound bytVe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='traf6'] controllert)e1: ents2Label-mention-ngram: SHARED 1 ist'e1: args2Role-mention-ngram: 1 is boundt7e1: trigger-arg-path: bound >agent [lemma='wash'] themetIe2: trigger-arg-path: ubiquitinated:Positive_regulation >agent controllertZe2: trigger-arg-path: ubiquitinated >agent [lemma='traf6'] controller:Gene_or_gene_productt=e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass themete2: trigger: ubiquitinatedt)e1: ents2Label-mention-ngram: is bound byt4e1: trigger-arg-path: bound:Binding >nsubjpass themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='wash'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: RING-typetFe1: trigger-arg-path: bound >agent [lemma='wash'] Gene_or_gene_productt-e2: args2Role-mention-ngram: by the RING-typetinterceding-token ngrams: LPSt(e1: ents2Label-mention-ngram: 1 is boundt*e1: trigger-arg-path: Binding >agent themet&e2: args2Role-mention-ngram: RING-typetJe2: trigger-arg-path: ubiquitinated >agent controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: bound by GENE_OR_GENE_PRODUCTtYtrigger-to-trigger-path: e1:bound:Binding >parataxis e2:ubiquitinated:Positive_regulationt?e1: trigger-arg-path: bound:Binding >agent Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >agent [lemma='wash'] theme:Gene_or_gene_producttinterceding-token ngrams: ) Int!e1: args2Role-mention-ngram: 1 ist?e1: trigger-arg-path: Binding >agent theme:Gene_or_gene_productt%interceding-token ngrams: macrophagestTe1: trigger-arg-path: Binding >nsubjpass [lemma='Beclin'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >agent Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='Beclin'] themetinterceding-token ngrams: ( f )toe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent controller:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubjpass [lemma='Beclin'] Gene_or_gene_productt5e2: trigger-arg-path: ubiquitinated >agent controllertWe1: trigger-arg-path: lemmatizedTrigger=bind >agent [lemma='wash'] Gene_or_gene_producttLe1: trigger-arg-path: bound >agent [lemma='wash'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='Beclin'] themet(e1: args2Role-mention-ngram: is bound bytZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass theme:Gene_or_gene_productt4interceding-token ngrams: In macrophages recognizingtte2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='traf6'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='traf6'] controllert+interceding-token ngrams: recognizing LPS ,t*e2: args2Role-mention-ngram: the RING-typet%e1: args2Role-mention-ngram: by THEMEtLe1: trigger-arg-path: bound >nsubjpass [lemma='Beclin'] Gene_or_gene_producttptrigger-to-trigger-path: e1:bound:Binding >parataxis [lemma='ubiquitinate'] e2:ubiquitinated:Positive_regulationtPe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent Gene_or_gene_productt`e2: trigger-arg-path: Positive_regulation >agent [lemma='traf6'] controller:Gene_or_gene_productt=e1: trigger-arg-path: bound >agent theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='traf6'] controller:Gene_or_gene_producttSe2: trigger-arg-path: ubiquitinated:Positive_regulation >agent Gene_or_gene_productt0e2: ents2Label-mention-ngram: 1 is ubiquitinatedt9e1: trigger-arg-path: Binding >agent Gene_or_gene_productt*interceding-token ngrams: ) In macrophagest(interceding-token ngrams: In macrophagestNe1: trigger-arg-path: Binding >agent [lemma='wash'] theme:Gene_or_gene_producttEe1: trigger-arg-path: bound:Binding >agent theme:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >agent [lemma='wash'] themet+e2: ents2Label-mention-ngram: the RING-typet?e2: trigger-arg-path: ubiquitinated >agent Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubjpass [lemma='Beclin'] themetke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='Beclin'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='Beclin'] theme:Gene_or_gene_productt9e2: ents2Label-mention-ngram: ligase GENE_OR_GENE_PRODUCTt+e2: ents2Label-mention-ngram: ubiquitinatedtCe1: trigger-arg-path: bound:Binding >nsubjpass Gene_or_gene_producttFinterceding-tokens-full-span: ; ( f ) In macrophages recognizing LPS ,t5interceding-token ngrams: macrophages recognizing LPSt;e1: trigger-arg-path: bound >nsubjpass Gene_or_gene_productt9e1: trigger-arg-path: lemmatizedTrigger=bind >agent themet'e1: args2Role-mention-ngram: THEME 1 ist,e1: trigger-arg-path: bound >nsubjpass themet^e2: trigger-arg-path: ubiquitinated:Positive_regulation >agent controller:Gene_or_gene_producttRe1: trigger-arg-path: bound >nsubjpass [lemma='Beclin'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: ligase CONTROLLERtinterceding-token ngrams: ( ftCe2: ents2Label-mention-ngram: RING-type ligase GENE_OR_GENE_PRODUCTtHe1: trigger-arg-path: lemmatizedTrigger=bind >agent [lemma='wash'] themetNe1: trigger-arg-path: bound:Binding >agent [lemma='wash'] Gene_or_gene_productt8e2: args2Role-mention-ngram: RING-type ligase CONTROLLERt=e1: trigger-arg-path: bound >nsubjpass [lemma='Beclin'] themet+e1: args2Role-mention-ngram: bound by THEMEt.e2: ents2Label-mention-ngram: RING-type ligasetAe1: trigger-arg-path: bound >nsubjpass theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: is boundt.e2: ents2Label-mention-ngram: is ubiquitinatedt7e1: trigger-arg-path: bind >nsubj [lemma='foxo1'] themet7e2: trigger-arg-path: complex >nn [lemma='foxo1'] themet>e1: trigger-arg-path: bind >prep_to theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='foxo1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: bind:Binding >nsubj [lemma='foxo1'] Gene_or_gene_producttotrigger-to-trigger-path: e1:bind:Binding >conj_and [lemma='impact'] >nsubj [lemma='complex'] e2:complex:Bindingt?e2: trigger-arg-path: complex:Binding >nn [lemma='foxo1'] themetEe2: trigger-arg-path: complex >nn [lemma='atg7'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg7'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atg7'] themet0interceding-token ngrams: an important regulatortWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atg7'] Gene_or_gene_productt-interceding-token ngrams: important regulatort*interceding-token ngrams: in autophagosometGe1: trigger-arg-path: bind >prep_to [lemma='atg7'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='atg7'] themetLe2: trigger-arg-path: complex >nn [lemma='foxo1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='foxo1'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='atg7'] theme:Gene_or_gene_productt8e1: trigger-arg-path: bind >prep_to Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='atg7'] Gene_or_gene_productt1interceding-token ngrams: autophagosome expansiontSe2: trigger-arg-path: complex:Binding >nn [lemma='atg7'] theme:Gene_or_gene_producttLe1: trigger-arg-path: bind >nsubj [lemma='foxo1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='foxo1'] themet$interceding-token ngrams: , which ist>e2: trigger-arg-path: complex:Binding >nn [lemma='atg7'] themetee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg7'] theme:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='atg7'] theme:Gene_or_gene_productt#interceding-token ngrams: importanttOe1: trigger-arg-path: bind:Binding >prep_to [lemma='atg7'] Gene_or_gene_productt)interceding-token ngrams: expansion , andtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='atg7'] Gene_or_gene_productt0interceding-token ngrams: important regulator intJe1: trigger-arg-path: Binding >prep_to [lemma='atg7'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='foxo1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='foxo1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='atg7'] themet"interceding-token ngrams: which istfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='foxo1'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='atg7'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='atg7'] themetFe1: trigger-arg-path: bind >nsubj [lemma='foxo1'] Gene_or_gene_productt%interceding-token ngrams: which is antLe2: trigger-arg-path: Binding >nn [lemma='foxo1'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='foxo1'] Gene_or_gene_productt%interceding-token ngrams: expansion ,tKe2: trigger-arg-path: Binding >nn [lemma='atg7'] theme:Gene_or_gene_producttinterceding-token ngrams: is antRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='atg7'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='atg7'] Gene_or_gene_productt'interceding-token ngrams: autophagosomet#interceding-token ngrams: regulatort&interceding-token ngrams: an importanttFe1: trigger-arg-path: bind:Binding >prep_to theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='foxo1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='foxo1'] Gene_or_gene_productt)interceding-token ngrams: is an importanttdinterceding-tokens-full-span: , which is an important regulator in autophagosome expansion , and thet4interceding-token ngrams: regulator in autophagosomet&interceding-token ngrams: regulator int_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='atg7'] theme:Gene_or_gene_productt@e1: trigger-arg-path: bind:Binding >prep_to [lemma='atg7'] themetFe2: trigger-arg-path: complex >nn [lemma='foxo1'] Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='atg7'] Gene_or_gene_productt@e1: trigger-arg-path: bind:Binding >prep_to Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='foxo1'] themetPe1: trigger-arg-path: Binding >prep_to [lemma='atg7'] theme:Gene_or_gene_producttUe1: trigger-arg-path: bind:Binding >prep_to [lemma='atg7'] theme:Gene_or_gene_productt3interceding-token ngrams: autophagosome expansion ,t]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='atg7'] theme:Gene_or_gene_producttMe1: trigger-arg-path: bind >prep_to [lemma='atg7'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='foxo1'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='foxo1'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='atg7'] themet#interceding-token ngrams: expansiontTe2: trigger-arg-path: complex:Binding >nn [lemma='foxo1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='foxo1'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='foxo1'] Gene_or_gene_producttTe1: trigger-arg-path: bind:Binding >nsubj [lemma='foxo1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='foxo1'] themet4interceding-token ngrams: in autophagosome expansiont?e1: trigger-arg-path: bind:Binding >nsubj [lemma='foxo1'] themetLtrigger-to-trigger-path: e1:bind:Binding >conj_and >nsubj e2:complex:BindingtOe1: trigger-arg-path: Binding >nsubj [lemma='foxo1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: complex:Binding >nn [lemma='foxo1'] Gene_or_gene_producttlshortest-path: conj_and [lemma='impact'] >nsubj [lemma='complex'] >nn [lemma='foxo1']t7e2: trigger-arg-path: Binding >nn [lemma='foxo1'] themet8e1: trigger-arg-path: bind >prep_to [lemma='atg7'] themet$e2: ents2Label-mention-ngram: of p21tPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='they'] controllertLe2: trigger-arg-path: promoted appos controlled:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent >nn controller:Gene_or_gene_producttBe2: trigger-arg-path: Positive_activation appos controlledtEe2: trigger-arg-path: lemmatizedTrigger=promote >agent >nn controllertee1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p21'] controlled:Gene_or_gene_producttCe1: trigger-arg-path: inhibit:Negative_activation >nsubj controllert\e2: trigger-arg-path: promoted appos [lemma='mdm2'] Gene_or_gene_productt"e2: args2Role-mention-ngram: p21 ,t{e2: trigger-arg-path: promoted:Positive_activation appos [lemma='mdm2'] controlled:Gene_or_gene_producttRe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='they'] controllertwe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p21'] controlled:Gene_or_gene_producttBe1: trigger-arg-path: inhibit >nsubj [lemma='they'] Generic_entityt)e2: ents2Label-mention-ngram: promoted byt%e2: args2Role-mention-ngram: of p21 ,t.e2: ents2Label-mention-ngram: is also promotedt:e1: ents2Label-mention-ngram: inhibit GENE_OR_GENE_PRODUCTt#e2: ents2Label-mention-ngram: p21 ,tRe1: trigger-arg-path: inhibit:Negative_activation >nsubj controller:Generic_entityt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos [lemma='mdm2'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: Negative_activation >nsubj [lemma='they'] controller:Generic_entitytre2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='signaling'] >nn [lemma='pi3k'] Gene_or_gene_productt"interceding-token ngrams: minute 2tNe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p21'] controlledtVe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='they'] Generic_entityt-e2: args2Role-mention-ngram: also promoted byt,shortest-path: prepc_by >dobj >appost-e2: args2Role-mention-ngram: regulator of p21t.interceding-token ngrams: by increasing murinet?e2: trigger-arg-path: promoted:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: GENERIC_ENTITY alsot(e2: args2Role-mention-ngram: promoted byt]e2: trigger-arg-path: lemmatizedTrigger=promote appos controlled:Gene_or_gene_productt=e1-label: Negative_activation + e2-label: Positive_activationt!e2: ents2Label-mention-ngram: p21tle1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p21'] Gene_or_gene_producttQe1: trigger-arg-path: inhibit >dobj [lemma='p21'] controlled:Gene_or_gene_productt interceding-token ngrams: minutetle2: trigger-arg-path: Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] Gene_or_gene_productt.interceding-token ngrams: murine double minutet]e2: trigger-arg-path: promoted:Positive_activation >agent >nn controller:Gene_or_gene_producttLe1: trigger-arg-path: inhibit:Negative_activation >dobj Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p21'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: a negative regulatort4e1: args2Role-mention-ngram: also inhibit CONTROLLEDtge2: trigger-arg-path: promoted appos [lemma='mdm2'] controlled:Gene_or_gene_productt)e2: args2Role-mention-ngram: , a negativetKe2: trigger-arg-path: promoted:Positive_activation appos controlledt'e2: ents2Label-mention-ngram: regulatortce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent >nn Gene_or_gene_producttIe2: trigger-arg-path: promoted >agent >nn controller:Gene_or_gene_productt2interceding-token ngrams: increasing murine doublet#e2: args2Role-mention-ngram: of p21twe2: trigger-arg-path: Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controller:Gene_or_gene_producttWe2: trigger-arg-path: promoted >agent [lemma='signaling'] >nn [lemma='pi3k'] controllert'interceding-token ngrams: indirectly byt?e1: ents2Label-mention-ngram: also inhibit GENE_OR_GENE_PRODUCTt)interceding-token ngrams: double minute 2tPe1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p21'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: of p21 ,tOinterceding-tokens-full-span: indirectly by increasing murine double minute 2 (t3e2: args2Role-mention-ngram: promoted by CONTROLLERtWe2: trigger-arg-path: Positive_activation appos controlled:Gene_or_gene_productt8e1: trigger-arg-path: inhibit >dobj Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='signaling'] >nn [lemma='pi3k'] controllertge2: trigger-arg-path: Positive_activation appos [lemma='mdm2'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: p21 , whicht]e1: trigger-arg-path: Negative_activation >dobj [lemma='p21'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: Negative_activation >nsubj [lemma='they'] controllert'interceding-token ngrams: by increasingtHe2: trigger-arg-path: lemmatizedTrigger=promote appos controlledt*e2: ents2Label-mention-ngram: regulator oft7e2: trigger-arg-path: promoted appos controlledtRe2: trigger-arg-path: promoted:Positive_activation >agent >nn Gene_or_gene_producttJe1: trigger-arg-path: Negative_activation >nsubj controller:Generic_entityt^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=promote appos [lemma='mdm2'] Gene_or_gene_producttdobj [lemma='p21'] controlledt2e2: args2Role-mention-ngram: negative regulator oft&e2: args2Role-mention-ngram: regulatortxe2: trigger-arg-path: lemmatizedTrigger=promote appos [lemma='mdm2'] controlled:Gene_or_gene_productt%e2: args2Role-mention-ngram: promotedt?e2: trigger-arg-path: Positive_activation >agent >nn controllert`e2: trigger-arg-path: promoted:Positive_activation appos controlled:Gene_or_gene_producttae1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='they'] controller:Generic_entitytOe2: trigger-arg-path: lemmatizedTrigger=promote >agent >nn Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='they'] controllertke2: trigger-arg-path: promoted:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controllertde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:Generic_entityt-e2: args2Role-mention-ngram: is also promotedt\e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos controlledtpe2: trigger-arg-path: promoted:Positive_activation appos [lemma='mdm2'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos [lemma='mdm2'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='they'] controller:Generic_entityt'interceding-token ngrams: murine doublet?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos [lemma='mdm2'] Gene_or_gene_producttCe1: trigger-arg-path: inhibit >dobj controlled:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj Generic_entityt4e1: args2Role-mention-ngram: CONTROLLER also inhibitt%e2: args2Role-mention-ngram: which ist/e1: args2Role-mention-ngram: inhibit CONTROLLEDt3e1: trigger-arg-path: inhibit >nsubj Generic_entityt)e1: args2Role-mention-ngram: also inhibitt%e2: ents2Label-mention-ngram: is alsotHe1: trigger-arg-path: Negative_activation >dobj [lemma='p21'] controlledt>e1: trigger-arg-path: inhibit >nsubj controller:Generic_entityt e2: args2Role-mention-ngram: p21tce2: trigger-arg-path: lemmatizedTrigger=promote appos [lemma='mdm2'] controlledt>e1: trigger-arg-path: inhibit >nsubj [lemma='they'] controllertle2: trigger-arg-path: promoted >agent [lemma='signaling'] >nn [lemma='pi3k'] controller:Gene_or_gene_productt]e2: trigger-arg-path: Positive_activation appos [lemma='mdm2'] controlledt&e2: ents2Label-mention-ngram: promotedt(e2: args2Role-mention-ngram: p21 , whichtie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj controlled:Gene_or_gene_productt interceding-token ngrams: murinet)e2: args2Role-mention-ngram: CONTROLLED )t>e2: trigger-arg-path: promoted >agent >nn Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj controlledtqe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos controlled:Gene_or_gene_producttMe1: trigger-arg-path: inhibit >nsubj [lemma='they'] controller:Generic_entityt9e1: ents2Label-mention-ngram: GENERIC_ENTITY also inhibitt*e2: args2Role-mention-ngram: which is alsotZe1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p21'] Gene_or_gene_productt)e2: args2Role-mention-ngram: regulator oft|e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controllert?e1: trigger-arg-path: Negative_activation >nsubj Generic_entitytLe2: trigger-arg-path: Positive_activation appos Gene_or_gene_producttTe2: trigger-arg-path: Positive_activation >agent >nn controller:Gene_or_gene_producttRe2: trigger-arg-path: promoted appos [lemma='mdm2'] controlledtbe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p21'] controlledtHe2: trigger-arg-path: promoted:Positive_activation >agent >nn controllertIe2: trigger-arg-path: Positive_activation >agent >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: promoted by GENE_OR_GENE_PRODUCTt+e2: args2Role-mention-ngram: CONTROLLED ) ,t?trigger-to-trigger-path: e1:inhibit:Negative_activation >prepc_by [lemma='increase'] >dobj [lemma='2'] >rcmod [lemma='promote'] e2:promoted:Positive_activationt'e2: args2Role-mention-ngram: , which ist4e2: trigger-arg-path: promoted >agent >nn controllert(e2: ents2Label-mention-ngram: a negativetfe2: trigger-arg-path: promoted:Positive_activation appos [lemma='mdm2'] controlledtAe2: trigger-arg-path: promoted appos Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:Gene_or_gene_productt.e1: trigger-arg-path: inhibit >dobj controlledt+interceding-token ngrams: increasing murinet+e2: ents2Label-mention-ngram: which is alsot'e2: args2Role-mention-ngram: a negativetYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >agent >nn controllert.e2: ents2Label-mention-ngram: also promoted byt*e1: ents2Label-mention-ngram: also inhibitt.e2: ents2Label-mention-ngram: regulator of p21tNe1: trigger-arg-path: Negative_activation >nsubj [lemma='they'] Generic_entityt*e2: args2Role-mention-ngram: also promotedte2: trigger: promotedt'interceding-token ngrams: double minutetfe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation appos Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=promote appos Gene_or_gene_producttae2: trigger-arg-path: promoted >agent [lemma='signaling'] >nn [lemma='pi3k'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='they'] controller:Generic_entitytce1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p21'] controlled:Gene_or_gene_producttBe1: trigger-arg-path: inhibit:Negative_activation >dobj controlledtTe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='they'] Generic_entitytue2: trigger-arg-path: promoted:Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: negative regulatortRe1: trigger-arg-path: Negative_activation >dobj [lemma='p21'] Gene_or_gene_producttUe2: trigger-arg-path: promoted:Positive_activation appos Gene_or_gene_productt$e2: args2Role-mention-ngram: is alsotre2: trigger-arg-path: Positive_activation appos [lemma='mdm2'] controlled:Gene_or_gene_productt/e2: args2Role-mention-ngram: negative regulatortGe1: trigger-arg-path: inhibit:Negative_activation >nsubj Generic_entitytlshortest-path: prepc_by [lemma='increase'] >dobj [lemma='2'] >appos [lemma='mdm2']t2interceding-token ngrams: indirectly by increasingt$interceding-token ngrams: increasingt+e2: ents2Label-mention-ngram: also promotedt$interceding-token ngrams: minute 2 (t1e2: args2Role-mention-ngram: a negative regulatort interceding-token ngrams: doubletWe1: trigger-arg-path: inhibit:Negative_activation >dobj controlled:Gene_or_gene_producttFe1: trigger-arg-path: inhibit >dobj [lemma='p21'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='they'] Generic_entityt3e2: ents2Label-mention-ngram: negative regulator oftntrigger-to-trigger-path: e1:inhibit:Negative_activation >prepc_by >dobj >rcmod e2:promoted:Positive_activationtbe2: trigger-arg-path: Positive_activation >agent [lemma='signaling'] >nn [lemma='pi3k'] controllert}e2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='signaling'] >nn [lemma='pi3k'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: , a negativetZe2: trigger-arg-path: lemmatizedTrigger=promote >agent >nn controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: directly to histonest?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controller:BioProcesst9e1: ents2Label-mention-ngram: SHARED mediated acetylationt-e1: args2Role-mention-ngram: Jun dimerizationt,e1: ents2Label-mention-ngram: both of SHAREDt-e1: ents2Label-mention-ngram: to histones andt!e1: args2Role-mention-ngram: DNAst&e1: args2Role-mention-ngram: ) , bindstde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='p300'] controllert?e1: trigger-arg-path: inhibits >nsubj >nn controller:BioProcesst)e1: args2Role-mention-ngram: dimerizationt(e1: args2Role-mention-ngram: directly totde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn controller:BioProcesstYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn controllert7e1: ents2Label-mention-ngram: mediated acetylation botht/e1: ents2Label-mention-ngram: histones and DNAst.e1: args2Role-mention-ngram: binds directly tot]e1: trigger-arg-path: inhibits >nsubj [lemma='factor'] >nn [lemma='transcription'] controllertTe2: trigger-arg-path: mediated >nsubj [lemma='p300'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: JDP2 )t"e1: ents2Label-mention-ngram: JDP2tye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_producttse1: trigger-arg-path: Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controller:BioProcesst4e1: trigger-arg-path: inhibits >nsubj >nn BioProcesst.e2: ents2Label-mention-ngram: acetylation botht?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] BioProcessthe1: trigger-arg-path: Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] BioProcesstPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='p300'] controllert/e1: ents2Label-mention-ngram: BIOPROCESS factortJe1: trigger-arg-path: Negative_regulation >nsubj >nn controller:BioProcesst]e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: protein 2the1: trigger-arg-path: inhibits >nsubj [lemma='factor'] >nn [lemma='transcription'] controller:BioProcesst'e1: ents2Label-mention-ngram: ) , bindst|e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controller:BioProcesst+e1: ents2Label-mention-ngram: then inhibitst2e1: ents2Label-mention-ngram: mediated acetylationtqe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controllert%e1: args2Role-mention-ngram: DNAs andt/e1: ents2Label-mention-ngram: and then inhibitst%e1: args2Role-mention-ngram: and thent9e2: ents2Label-mention-ngram: SHARED mediated acetylationtye1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='factor'] >nn [lemma='transcription'] controller:BioProcesst&e1: ents2Label-mention-ngram: DNAs andthe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER factor ,t,e1: ents2Label-mention-ngram: binds directlyt"e1: args2Role-mention-ngram: , Junt,e2: ents2Label-mention-ngram: both of SHAREDtEe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn BioProcesst*e1: args2Role-mention-ngram: DNAs and thentYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn BioProcesst&e1: ents2Label-mention-ngram: and thent*e1: ents2Label-mention-ngram: dimerizationt)e1: args2Role-mention-ngram: histones andt]e1: trigger-arg-path: inhibits >nsubj [lemma='factor'] >nn [lemma='transcription'] BioProcesst.e1: args2Role-mention-ngram: CONTROLLER factort e1: args2Role-mention-ngram: Junt)e1: args2Role-mention-ngram: factor , JuntTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: 2 (t%e1: args2Role-mention-ngram: factor ,tHe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn controllertqe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] BioProcesst6e1: ents2Label-mention-ngram: Jun dimerization proteint1e1: ents2Label-mention-ngram: acetylation both oft"e1: ents2Label-mention-ngram: DNAst1e1: ents2Label-mention-ngram: BIOPROCESS factor ,t&e1: ents2Label-mention-ngram: factor ,t,e1: args2Role-mention-ngram: to histones andt?e1: trigger-arg-path: Negative_regulation >nsubj >nn BioProcesst?e2: trigger-arg-path: mediated >nsubj [lemma='p300'] controllert$e1: ents2Label-mention-ngram: ( JDP2t#e1: ents2Label-mention-ngram: , Juntne1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='factor'] >nn [lemma='transcription'] controllert$e1: ents2Label-mention-ngram: factort!e1: args2Role-mention-ngram: JDP2t)e1: ents2Label-mention-ngram: to histonest)e1: ents2Label-mention-ngram: protein 2 (t3e1: args2Role-mention-ngram: dimerization protein 2t.e1: ents2Label-mention-ngram: , binds directlytne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_productt%e1: args2Role-mention-ngram: JDP2 ) ,t#e1: args2Role-mention-ngram: factort.e1: ents2Label-mention-ngram: acetylation botht5e1: args2Role-mention-ngram: Jun dimerization proteint/e1: ents2Label-mention-ngram: binds directly tot*e1: args2Role-mention-ngram: then inhibitstHe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn BioProcesst%e1: args2Role-mention-ngram: ( JDP2 )t.e1: args2Role-mention-ngram: histones and DNAstee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='p300'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: factor , Junt)e1: args2Role-mention-ngram: and DNAs andt*e1: ents2Label-mention-ngram: histones andt4e1: ents2Label-mention-ngram: dimerization protein 2t&e1: ents2Label-mention-ngram: JDP2 ) ,t1e2: ents2Label-mention-ngram: acetylation both oft.e1: args2Role-mention-ngram: then inhibits thet2e1: ents2Label-mention-ngram: dimerization proteintJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] controllert&e1: ents2Label-mention-ngram: ( JDP2 )tSe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='p300'] controllertne1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='factor'] >nn [lemma='transcription'] BioProcesst%e2: ents2Label-mention-ngram: both oft%e1: args2Role-mention-ngram: histonest0e1: ents2Label-mention-ngram: , Jun dimerizationt#e1: args2Role-mention-ngram: ( JDP2t.e1: ents2Label-mention-ngram: Jun dimerizationt/e1: args2Role-mention-ngram: , Jun dimerizationt&e1: ents2Label-mention-ngram: histonest.e1: args2Role-mention-ngram: and then inhibitst-e1: args2Role-mention-ngram: , binds directlyt!e1: ents2Label-mention-ngram: Junt%e1: args2Role-mention-ngram: 2 ( JDP2t)e1: ents2Label-mention-ngram: directly tot(e1: args2Role-mention-ngram: protein 2 (t(e1: args2Role-mention-ngram: to histonest&e1: args2Role-mention-ngram: protein 2te1: outgoing: >preconjt2e1: ents2Label-mention-ngram: directly to histonestZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='p300'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controllert2e2: ents2Label-mention-ngram: mediated acetylationte2: outgoing: >preconjt+e1: ents2Label-mention-ngram: DNAs and thent&e1: ents2Label-mention-ngram: 2 ( JDP2t7e2: ents2Label-mention-ngram: mediated acetylation botht*e1: ents2Label-mention-ngram: and DNAs andt%e1: ents2Label-mention-ngram: both oft%e1: args2Role-mention-ngram: and DNAsthe1: trigger-arg-path: Negative_regulation >nsubj [lemma='factor'] >nn [lemma='transcription'] controllertSe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn controller:BioProcesst1e1: args2Role-mention-ngram: dimerization proteint$e1: ents2Label-mention-ngram: JDP2 )tIe2: trigger-arg-path: mediated >nsubj [lemma='p300'] Gene_or_gene_productt e1: args2Role-mention-ngram: 2 (t&e1: ents2Label-mention-ngram: and DNAstkshortest-path: ccomp [lemma='mediate'] >nsubj [lemma='p300']tPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:BioProcesst+e1: args2Role-mention-ngram: binds directlyt/e1: ents2Label-mention-ngram: then inhibits thetoe1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj >nn controller:Gene_or_gene_productt!interceding-token ngrams: whethertUe2: trigger-arg-path: Binding >prep_between [lemma='fbw7'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interaction >prep_between [lemma='fbw7'] Gene_or_gene_productt)interceding-token ngrams: we investigatedt$interceding-token ngrams: there is at4interceding-token ngrams: investigated whether theretke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='erk1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fbw7'] Gene_or_gene_productt^e1: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='erk1'] themetre1: trigger-arg-path: modulates:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=modulate >dobj >nn Gene_or_gene_producttie1: trigger-arg-path: modulates >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt5e1: trigger-arg-path: modulates >nsubj >nn controllert]e1: trigger-arg-path: modulates:Positive_activation >dobj >nn controlled:Gene_or_gene_productt#interceding-token ngrams: stabilityt'interceding-token ngrams: whether theretke1: trigger-arg-path: modulates:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlledtue1: trigger-arg-path: modulates:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fbw7'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn controller:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=modulate >dobj >nn controlledtke1: trigger-arg-path: Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] Gene_or_gene_productt*interceding-token ngrams: whether there ist-e1: args2Role-mention-ngram: kinase modulatest"interceding-token ngrams: a directtle1: trigger-arg-path: modulates >dobj [lemma='stability'] >nn [lemma='fbw7'] controlled:Gene_or_gene_producttinterceding-token ngrams: , wet[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='erk1'] Gene_or_gene_productt?shortest-path: ccomp [lemma='be'] >nsubj [lemma='interaction']tDe2: trigger-arg-path: interaction >prep_between [lemma='erk1'] themet?e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] Gene_or_gene_producttUe2: trigger-arg-path: Binding >prep_between [lemma='erk1'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: kinase modulates SHAREDt?e1: trigger-arg-path: modulates >nsubj >nn Gene_or_gene_productt^e1: trigger-arg-path: modulates:Positive_activation >nsubj >nn controller:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='stability'] >nn [lemma='fbw7'] controlledt.e1: ents2Label-mention-ngram: modulates SHAREDtoe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt%interceding-token ngrams: is a directt?trigger-to-trigger-path: e1:modulates:Positive_activation ccomp [lemma='be'] >nsubj [lemma='interaction'] e2:interaction:BindingtVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fbw7'] themetotrigger-to-trigger-path: e1:modulates:Positive_activation ccomp >nsubj e2:interaction:Bindingtye1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertinterceding-token ngrams: theret?e1: trigger-arg-path: modulates:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlled:Gene_or_gene_productt}e1: trigger-arg-path: modulates:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='fbw7'] Gene_or_gene_productt>e1: trigger-arg-path: modulates >dobj >nn Gene_or_gene_producttIe1: trigger-arg-path: modulates >dobj >nn controlled:Gene_or_gene_productt8e1: args2Role-mention-ngram: CONTROLLER kinase modulatest?e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttYe2: trigger-arg-path: interaction >prep_between [lemma='fbw7'] theme:Gene_or_gene_productt4e1: trigger-arg-path: modulates >dobj >nn controlledtae1: trigger-arg-path: Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlledtve1: trigger-arg-path: Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlled:Gene_or_gene_productt8shortest-path: ccomp >nsubjtOe2: trigger-arg-path: Binding >prep_between [lemma='erk1'] Gene_or_gene_productt8e1: args2Role-mention-ngram: kinase modulates CONTROLLEDtTe1: trigger-arg-path: modulates >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fbw7'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: modulates CONTROLLEDtse1: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_between [lemma='fbw7'] themetinterceding-token ngrams: wetIe1: trigger-arg-path: modulates:Positive_activation >nsubj >nn controllertSe1: trigger-arg-path: modulates:Positive_activation >nsubj >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='fbw7'] themetZe1: trigger-arg-path: lemmatizedTrigger=modulate >dobj >nn controlled:Gene_or_gene_producttHe1: trigger-arg-path: modulates:Positive_activation >dobj >nn controlledtae2: trigger-arg-path: interaction:Binding >prep_between [lemma='fbw7'] theme:Gene_or_gene_producttYe2: trigger-arg-path: interaction >prep_between [lemma='erk1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='erk1'] themetYe1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >nn controlledtRe1: trigger-arg-path: modulates:Positive_activation >dobj >nn Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >nn controlled:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn controllert@e2: trigger-arg-path: Binding >prep_between [lemma='erk1'] themetae1: trigger-arg-path: modulates >dobj [lemma='stability'] >nn [lemma='fbw7'] Gene_or_gene_producttCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinase modulatest^e1: trigger-arg-path: modulates >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt&interceding-token ngrams: investigatedtOe2: trigger-arg-path: Binding >prep_between [lemma='fbw7'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='erk1'] theme:Gene_or_gene_producttSinterceding-tokens-full-span: stability , we investigated whether there is a directtee1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertre1: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='stability'] >nn [lemma='fbw7'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj >nn controllert%interceding-token ngrams: stability ,t}e1: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='stability'] >nn [lemma='fbw7'] controlled:Gene_or_gene_productthe1: trigger-arg-path: modulates:Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert(interceding-token ngrams: stability , wet^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fbw7'] themetae2: trigger-arg-path: interaction:Binding >prep_between [lemma='erk1'] theme:Gene_or_gene_productt+interceding-token ngrams: , we investigatedt.interceding-token ngrams: investigated whethert"interceding-token ngrams: there istze1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttSe2: trigger-arg-path: interaction >prep_between [lemma='erk1'] Gene_or_gene_producttDe2: trigger-arg-path: interaction >prep_between [lemma='fbw7'] themetke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fbw7'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='erk1'] Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='erk1'] themet1interceding-token ngrams: we investigated whethertWe1: trigger-arg-path: modulates >dobj [lemma='stability'] >nn [lemma='fbw7'] controlledtde1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj >nn Gene_or_gene_productthe1: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: kinase modulatestJe1: trigger-arg-path: modulates >nsubj >nn controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='erk1'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='stability'] >nn [lemma='fbw7'] controlledtprep_of [lemma='nipp1'] themetie2: trigger-arg-path: binding:Binding prep_to [lemma='ezh2'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ezh2'] theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding conj_and >nsubj >nn Sitet1interceding-token ngrams: phosphorylation inducest?e2: trigger-arg-path: Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] Sitet^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and >nsubj >nn SitetKe2: trigger-arg-path: Binding >prep_of [lemma='nipp1'] Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] Sitet?e2: trigger-arg-path: Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] site:SitetIe2: trigger-arg-path: Binding conj_and >nsubj >nn site:Sitet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] site:Sitetge2: trigger-arg-path: Binding prep_to [lemma='ezh2'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and >nsubj >nn site:SitetKe2: trigger-arg-path: binding >prep_of [lemma='nipp1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: and both SITEtUtrigger-to-trigger-path: e1:association:Binding advcl >dobj e2:binding:Bindingt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ezh2'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding conj_and >nsubj >nn Sitet!shortest-path: advcl >dobjtge2: trigger-arg-path: binding prep_to [lemma='ezh2'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: to THEME ,tYe2: trigger-arg-path: binding:Binding >prep_of [lemma='nipp1'] theme:Gene_or_gene_productt9interceding-tokens-full-span: phosphorylation induces thetQe2: trigger-arg-path: binding:Binding conj_and >nsubj >nn site:Sitet?e2: trigger-arg-path: binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] sitet%e2: args2Role-mention-ngram: and botht?trigger-to-trigger-path: e1:association:Binding advcl [lemma='induce'] >dobj [lemma='binding'] e2:binding:BindingtDe2: trigger-arg-path: binding conj_and >nsubj >nn sitetNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nipp1'] themet5interceding-token ngrams: phosphorylation induces thet%interceding-token ngrams: induces thet(e2: args2Role-mention-ngram: THEME , andt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] sitetee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nipp1'] Gene_or_gene_productt'e2: args2Role-mention-ngram: , and bothtLe2: trigger-arg-path: binding:Binding conj_and >nsubj >nn sitetle2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ezh2'] themet?e2: trigger-arg-path: binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] Sitet?e2: trigger-arg-path: binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] site:Sitet?e2: trigger-arg-path: binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] site:Sitetprep_of [lemma='nipp1'] themetoe2: trigger-arg-path: binding:Binding prep_to [lemma='ezh2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] sitetQe2: trigger-arg-path: binding >prep_of [lemma='nipp1'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nipp1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding prep_to [lemma='ezh2'] themetDe2: trigger-arg-path: binding:Binding >prep_of [lemma='nipp1'] themetSe2: trigger-arg-path: binding:Binding >prep_of [lemma='nipp1'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ezh2'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] Sitet]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nipp1'] Gene_or_gene_productte2: SITE: 5tke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nipp1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding conj_and >nsubj >nn sitetse2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ezh2'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT ,tae2: trigger-arg-path: binding prep_to [lemma='ezh2'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding conj_and >nsubj >nn site:SitetDe2: trigger-arg-path: binding conj_and >nsubj >nn Sitet{e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ezh2'] Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_of [lemma='nipp1'] theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding conj_and >nsubj >nn sitetZe2: trigger-arg-path: binding:Binding prep_to [lemma='ezh2'] themetVshortest-path: advcl [lemma='induce'] >dobj [lemma='binding']tVe2: trigger-arg-path: lemmatizedTrigger=binding conj_and >nsubj >nn sitet&e2: args2Role-mention-ngram: both SITEtLe2: trigger-arg-path: binding:Binding conj_and >nsubj >nn SitetVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nipp1'] themet?e2: trigger-arg-path: Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] sitet?e2: trigger-arg-path: lemmatizedTrigger=binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] site:Sitetprep_to [lemma='ezh2'] themetIe2: trigger-arg-path: binding conj_and >nsubj >nn site:Sitetae2: trigger-arg-path: Binding prep_to [lemma='ezh2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] Sitet?e2: trigger-arg-path: binding:Binding conj_and [lemma='critical'] >nsubj [lemma='phosphorylation'] >nn [lemma='t345'] sitet@e1: trigger-arg-path: lemmatizedTrigger=complex >nn theme:FamilytNe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] themetJe1: trigger-arg-path: complex >nn [lemma='raf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: Binding >nn [lemma='raf'] Gene_or_gene_productt5e1: trigger-arg-path: complex >nn [lemma='raf'] themetJe1: trigger-arg-path: Binding >nn [lemma='raf'] theme:Gene_or_gene_productt:e1: trigger-arg-path: lemmatizedTrigger=complex >nn Familyt?shortest-path: conj_but >nsubjpass >prep_oftnn [lemma='ra'] themet.e1: trigger-arg-path: complex >nn theme:Familyt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to disruptt4e1: trigger-arg-path: Binding >nn [lemma='ra'] themet(e1: trigger-arg-path: Binding >nn FamilytUe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] theme:FamilytOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] Familyt?trigger-to-trigger-path: e1:complex:Binding conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110'] >vmod [lemma='disrupt'] e2:disrupt:Negative_regulationt0e1: trigger-arg-path: complex:Binding >nn FamilytVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf'] Gene_or_gene_producttRe1: trigger-arg-path: complex:Binding >nn [lemma='raf'] theme:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] themet=e1: trigger-arg-path: complex:Binding >nn [lemma='ra'] Familyt5e1: trigger-arg-path: Binding >nn [lemma='ra'] FamilytBe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn Familyt.e1: trigger-arg-path: Binding >nn theme:FamilytMe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] theme:FamilytLe1: trigger-arg-path: complex:Binding >nn [lemma='raf'] Gene_or_gene_productt(e1: trigger-arg-path: complex >nn Familyt5e1: trigger-arg-path: complex >nn [lemma='ra'] Familyt=e1: trigger-arg-path: complex:Binding >nn [lemma='raf'] themet}trigger-to-trigger-path: e1:complex:Binding conj_but >nsubjpass >prep_of >vmod e2:disrupt:Negative_regulationt\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] FamilytOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf'] themet;e1: trigger-arg-path: complex >nn [lemma='ra'] theme:FamilytHe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn theme:FamilytDe1: trigger-arg-path: complex >nn [lemma='raf'] Gene_or_gene_producttCe1: trigger-arg-path: complex:Binding >nn [lemma='ra'] theme:Familyt6e1: trigger-arg-path: complex:Binding >nn theme:Familytde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf'] theme:Gene_or_gene_productt?shortest-path: conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110']tGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf'] themet5e1: trigger-arg-path: Binding >nn [lemma='raf'] themet;e1: trigger-arg-path: Binding >nn [lemma='ra'] theme:Familyt4e1: trigger-arg-path: complex >nn [lemma='ra'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf'] Gene_or_gene_productt?e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: increases CONTROLLEDtgtrigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controller:Gene_or_gene_producttVe1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by controllertLe1: trigger-arg-path: phosphorylation >prep_of >prep_by Gene_or_gene_productt}e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controllertte1: trigger-arg-path: phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controller:Gene_or_gene_productt@e2: ents2Label-mention-ngram: increases GENE_OR_GENE_PRODUCT andtprep_of >prep_by controllert0e2: ents2Label-mention-ngram: and SHARED bindingtke1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttztrigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controllertCe2: ents2Label-mention-ngram: SHARED increases GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] Gene_or_gene_productt`e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt1e2: ents2Label-mention-ngram: by SHARED increasest_e1: trigger-arg-path: phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controllert.e2: ents2Label-mention-ngram: SHARED increasest?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controllertme1: trigger-arg-path: Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] Gene_or_gene_producttse1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controllert'e2: ents2Label-mention-ngram: increasest?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] controller:Gene_or_gene_productte2: trigger: increasestie1: trigger-arg-path: phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] Gene_or_gene_producttWe1: trigger-arg-path: phosphorylation >prep_of >prep_by controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='nrf2'] >prep_by [lemma='p38'] Gene_or_gene_productt&e2: args2Role-mention-ngram: increasest"e2: ents2Label-mention-ngram: Mek1t(e2: ents2Label-mention-ngram: ( Mek1 andt&e1: ents2Label-mention-ngram: the onlyt&e2: ents2Label-mention-ngram: the onlyt&e2: ents2Label-mention-ngram: Mek2 ) ,t5e1: ents2Label-mention-ngram: phosphorylates Erk1 andt&e1: ents2Label-mention-ngram: Mek2 ) ,t'e1: ents2Label-mention-ngram: ) , whicht!e1: args2Role-mention-ngram: Mek2t'e2: args2Role-mention-ngram: ( Mek1 andt(e2: ents2Label-mention-ngram: only knownt"e1: ents2Label-mention-ngram: Erk2t!e1: args2Role-mention-ngram: turnt+e1: ents2Label-mention-ngram: which in turnt4e1: ents2Label-mention-ngram: in turn phosphorylatest$e1: args2Role-mention-ngram: , whichtse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='p29ing4'] themet3e1: ents2Label-mention-ngram: enhances the p300-p53tCshortest-path: dobj [lemma='interaction']t|e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='p33ing2'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: p28ING5tKe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj [lemma='p29ing4'] themet.e1: args2Role-mention-ngram: also enhances thet+e2: args2Role-mention-ngram: p53 and inducet:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p53t?e2: trigger-arg-path: form complexes conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] sitetEe1: trigger-arg-path: enhances >dobj [lemma='interaction'] controlledt1e2: args2Role-mention-ngram: complexes with THEMEtoe2: trigger-arg-path: form complexes:Binding nsubj [lemma='p29ing4'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] site:Sitet[e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and >dobj >nn sitete2: SITE: 4tqe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with [lemma='p300'] themet2e1: trigger-arg-path: enhances >dobj Generic_eventtWe1: trigger-arg-path: enhances >nsubj [lemma='p33ing2'] controller:Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER also enhancest6e1: ents2Label-mention-ngram: the p300-p53 interactiontVe2: trigger-arg-path: lemmatizedTrigger=form complex nsubj Gene_or_gene_productt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p28ING5t?e2: trigger-arg-path: Binding nsubj Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=form complex prep_with [lemma='p300'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] sitet\e2: trigger-arg-path: lemmatizedTrigger=form complex nsubj theme:Gene_or_gene_productt0e2: trigger-arg-path: Binding nsubj themetKe2: trigger-arg-path: form complexes:Binding conj_and >dobj >nn Sitetme1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='interaction'] Generic_eventthe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='p33ing2'] controller:Gene_or_gene_producttPe2: trigger-arg-path: form complexes prep_with theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: complexes withtSe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with themet?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] site:Sitet;e2: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCT andt,e2: ents2Label-mention-ngram: complexes withtpe2: trigger-arg-path: form complexes:Binding prep_with [lemma='p300'] Gene_or_gene_producttge2: trigger-arg-path: form complexes nsubj [lemma='p29ing4'] Gene_or_gene_producttCe2: trigger-arg-path: Binding prep_with Gene_or_gene_producttFe2: trigger-arg-path: form complexes nsubj Gene_or_gene_productt/e2: args2Role-mention-ngram: can form complexest`e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and >dobj >nn site:Sitet1e2: ents2Label-mention-ngram: form complexes witht?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with [lemma='p300'] theme:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlledt*e1: ents2Label-mention-ngram: enhances thetHe1: trigger-arg-path: Positive_regulation >dobj controlled:Generic_eventtke1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='p33ing2'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=form complex prep_with Gene_or_gene_productt(e2: args2Role-mention-ngram: p28ING5 cantge1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='p33ing2'] controllertYe2: trigger-arg-path: form complexes prep_with [lemma='p300'] themetae2: trigger-arg-path: form complexes:Binding prep_with [lemma='p300'] themet@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also enhancestue2: trigger-arg-path: form complexes:Binding nsubj [lemma='p29ing4'] theme:Gene_or_gene_productt?e2: trigger-arg-path: form complexes conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] site:Sitet?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] Sitet)e2: ents2Label-mention-ngram: and p53 andtJe2: trigger-arg-path: form complexes prep_with Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=form complex prep_with [lemma='p300'] themet"e2: ents2Label-mention-ngram: K382t[e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding conj_and >dobj >nn Sitet*e2: args2Role-mention-ngram: THEME and p53t-e2: args2Role-mention-ngram: p28ING5 can formt=e1: trigger-arg-path: Positive_regulation >dobj Generic_eventt)e1: args2Role-mention-ngram: the p300-p53tVe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='interaction'] controlledt0e2: ents2Label-mention-ngram: can form complexestAe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controllert4e2: trigger-arg-path: Binding prep_with themetCe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj Generic_eventt'e2: args2Role-mention-ngram: and inducet"e2: ents2Label-mention-ngram: formt?e2: trigger-arg-path: Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] site:SitetSe2: trigger-arg-path: lemmatizedTrigger=form complex conj_and >dobj >nn Sitet(e2: args2Role-mention-ngram: and p53 andtXe2: trigger-arg-path: form complexes nsubj [lemma='p29ing4'] themetEe1: trigger-arg-path: enhances >nsubj controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: induce K382t%e1: args2Role-mention-ngram: p300-p53t?e2: trigger-arg-path: Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] sitetWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p33ing2'] Gene_or_gene_productt`e1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='p33ing2'] Gene_or_gene_productt*e1: args2Role-mention-ngram: also enhancest:e1: trigger-arg-path: enhances >nsubj Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='interaction'] controlledtde1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='interaction'] controlled:Generic_eventthe2: trigger-arg-path: form complexes prep_with [lemma='p300'] Gene_or_gene_productt?e2: trigger-arg-path: form complexes conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] SitetYe1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='interaction'] controlledtWe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj Generic_eventt~e2: trigger-arg-path: lemmatizedTrigger=form complex prep_with [lemma='p300'] theme:Gene_or_gene_producttme2: trigger-arg-path: form complexes nsubj [lemma='p29ing4'] theme:Gene_or_gene_producttLe2: trigger-arg-path: form complexes nsubj theme:Gene_or_gene_productt\e1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='interaction'] Generic_eventt&e1: ents2Label-mention-ngram: p300-p53tHe1: trigger-arg-path: enhances >dobj [lemma='interaction'] Generic_eventt%e2: ents2Label-mention-ngram: and p53t4e1: args2Role-mention-ngram: the p300-p53 CONTROLLEDt(e2: ents2Label-mention-ngram: and inducet/e1: ents2Label-mention-ngram: also enhances thet/e1: trigger-arg-path: enhances >dobj controlledtqe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='p33ing2'] Gene_or_gene_productt?e2: trigger-arg-path: form complexes:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] site:SitetSe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='p33ing2'] controllert?e2: trigger-arg-path: form complexes:Binding nsubj themet-e2: ents2Label-mention-ngram: and p28ING5 cantTe2: trigger-arg-path: form complexes:Binding nsubj theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: p300-p53 CONTROLLEDt2e1: ents2Label-mention-ngram: p300-p53 interactiont(e2: args2Role-mention-ngram: induce SITEtAe2: trigger-arg-path: Binding conj_and >dobj >nn site:Sitet%e2: args2Role-mention-ngram: can formtKe2: trigger-arg-path: lemmatizedTrigger=form complex prep_with themetSe1: trigger-arg-path: Positive_regulation >dobj [lemma='interaction'] Generic_eventtSe1: trigger-arg-path: enhances >dobj [lemma='interaction'] controlled:Generic_eventt;e2: trigger-arg-path: form complexes prep_with themetFe1: trigger-arg-path: enhances:Positive_regulation >dobj Generic_eventtXe2: trigger-arg-path: form complexes:Binding prep_with theme:Gene_or_gene_productt7e1-label: Positive_regulation + e2-label: Generic_eventtconj_and >dobj >nn sitet0e2: args2Role-mention-ngram: form complexes withtDe1: trigger-arg-path: enhances:Positive_regulation >nsubj controllert)e2: ents2Label-mention-ngram: and p28ING5t*e1: ents2Label-mention-ngram: the p300-p53tLe1: trigger-arg-path: enhances >nsubj [lemma='p33ing2'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: inducet,e2: args2Role-mention-ngram: and p28ING5 cant^e1: trigger-arg-path: Positive_regulation >dobj [lemma='interaction'] controlled:Generic_eventtIe2: trigger-arg-path: Binding prep_with theme:Gene_or_gene_productt?e2: trigger-arg-path: form complexes:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] sitetCe2: trigger-arg-path: form complexes conj_and >dobj >nn sitet?e2: trigger-arg-path: Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] SitetOe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj themetXe2: trigger-arg-path: lemmatizedTrigger=form complex conj_and >dobj >nn site:SitetNe1: trigger-arg-path: enhances:Positive_regulation >nsubj Gene_or_gene_productt=e1: trigger-arg-path: enhances >dobj controlled:Generic_eventtNe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlled:Generic_eventtAe2: ents2Label-mention-ngram: complexes with GENE_OR_GENE_PRODUCTte2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj [lemma='p29ing4'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='interaction'] controlled:Generic_eventtbe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with Gene_or_gene_producttae2: trigger-arg-path: Binding prep_with [lemma='p300'] Gene_or_gene_producttMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p33ing2'] controllert`e2: trigger-arg-path: Binding nsubj [lemma='p29ing4'] Gene_or_gene_producttqtrigger-to-trigger-path: e1:enhances:Positive_regulation >dobj [lemma='interaction'] e2:interaction:Generic_eventtHe2: trigger-arg-path: form complexes conj_and >dobj >nn site:Sitet$e2: args2Role-mention-ngram: and p53t]e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='p33ing2'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controller:Gene_or_gene_producttve2: trigger-arg-path: form complexes:Binding prep_with [lemma='p300'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj theme:Gene_or_gene_producttPe2: trigger-arg-path: form complexes:Binding conj_and >dobj >nn site:Sitethe2: trigger-arg-path: lemmatizedTrigger=form complex nsubj [lemma='p29ing4'] themetYe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='interaction'] Generic_eventtbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p33ing2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with [lemma='p300'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj controller:Gene_or_gene_producttne2: trigger-arg-path: form complexes prep_with [lemma='p300'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=form complex prep_with theme:Gene_or_gene_producttge2: trigger-arg-path: Binding prep_with [lemma='p300'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: can formtYe1: trigger-arg-path: enhances:Positive_regulation >nsubj controller:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlledt0e1: trigger-arg-path: enhances >nsubj controllert,e2: ents2Label-mention-ngram: form complexest$e2: args2Role-mention-ngram: p53 andt+e2: args2Role-mention-ngram: form complexestUe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj controllertKe2: trigger-arg-path: form complexes:Binding conj_and >dobj >nn sitetconj_and >dobj >nn SitetCe2: trigger-arg-path: form complexes:Binding prep_with themet.e2: args2Role-mention-ngram: THEME and p28ING5tNe2: trigger-arg-path: form complexes:Binding nsubj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] sitetCe2: trigger-arg-path: form complexes conj_and >dobj >nn Sitet`e2: trigger-arg-path: form complexes:Binding nsubj [lemma='p29ing4'] themet+e2: args2Role-mention-ngram: with THEME andtCe1: trigger-arg-path: enhances:Positive_regulation >dobj controlledt)e1: args2Role-mention-ngram: enhances thetwe2: trigger-arg-path: lemmatizedTrigger=form complex nsubj [lemma='p29ing4'] Gene_or_gene_productt?e2: trigger-arg-path: form complexes:Binding conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] SitetBe1: trigger-arg-path: enhances >nsubj [lemma='p33ing2'] controllert#e2: args2Role-mention-ngram: inducetbe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlled:Generic_eventtQe1: trigger-arg-path: enhances:Positive_regulation >dobj controlled:Generic_eventt%e2: ents2Label-mention-ngram: p28ING5t,e2: ents2Label-mention-ngram: p53 and inducetRe2: trigger-arg-path: Binding prep_with [lemma='p300'] themet(e2: args2Role-mention-ngram: and p28ING5t,e2: args2Role-mention-ngram: and induce SITEtge1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='interaction'] controlled:Generic_eventt-e2: ents2Label-mention-ngram: and induce K382te2: trigger: form complexest!e2: args2Role-mention-ngram: formtPe1: trigger-arg-path: Positive_regulation >dobj [lemma='interaction'] controlledtGe2: trigger-arg-path: lemmatizedTrigger=form complex nsubj themethe2: trigger-arg-path: lemmatizedTrigger=form complex:Binding prep_with theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex:Binding nsubj [lemma='p29ing4'] theme:Gene_or_gene_producttRe2: trigger-arg-path: form complexes:Binding prep_with Gene_or_gene_producttVe1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='p33ing2'] controllert+e1: ents2Label-mention-ngram: also enhancestfe2: trigger-arg-path: Binding nsubj [lemma='p29ing4'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=form complex conj_and >dobj >nn sitet2e1: args2Role-mention-ngram: enhances the p300-p53tEe2: trigger-arg-path: Binding nsubj theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form complex conj_and [lemma='induce'] >dobj [lemma='acetylation'] >nn [lemma='k382'] Sitet[trigger-to-trigger-path: e1:enhances:Positive_regulation >dobj e2:interaction:Generic_eventt)e2: ents2Label-mention-ngram: p28ING5 cant.e2: ents2Label-mention-ngram: p28ING5 can formt}e2: trigger-arg-path: lemmatizedTrigger=form complex nsubj [lemma='p29ing4'] theme:Gene_or_gene_productt7e2: trigger-arg-path: form complexes nsubj themet?e1: trigger-arg-path: binds:Binding >dobj [lemma='smad4'] themet9e1: trigger-arg-path: Binding >dobj [lemma='smad4'] themet_e1: trigger-arg-path: binds:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] themetYe1: trigger-arg-path: Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] themetTe2: trigger-arg-path: complex:Binding >nn [lemma='smad4'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj >dobj theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] themet'interceding-tokens-full-span: forming atMe2: trigger-arg-path: Binding >nn [lemma='r-smad'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Binding >dobj [lemma='smad4'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=bind >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complex >nn [lemma='r-smad'] theme:Gene_or_gene_productt.e1: trigger-arg-path: binds >csubj >dobj themetNe1: trigger-arg-path: binds:Binding >dobj [lemma='smad4'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='r-smad'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smad4'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='smad4'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='r-smad'] Gene_or_gene_producttWe1: trigger-arg-path: binds >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj >dobj Gene_or_gene_productt#interceding-token ngrams: forming at?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds SHAREDtEe1: trigger-arg-path: Binding >csubj >dobj theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='smad4'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='smad4'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binds >csubj >dobj theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='r-smad'] themet!interceding-token ngrams: formingtee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='smad4'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >csubj >dobj Gene_or_gene_producttFe1: trigger-arg-path: binds >dobj [lemma='smad4'] Gene_or_gene_producttfe1: trigger-arg-path: binds >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj >dobj themetIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smad4'] themetfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smad4'] theme:Gene_or_gene_producttLe1: trigger-arg-path: binds >dobj [lemma='smad4'] theme:Gene_or_gene_productt=e1: trigger-arg-path: binds >csubj >dobj Gene_or_gene_productt7e2: trigger-arg-path: Binding >nn [lemma='smad4'] themetEe1: trigger-arg-path: binds:Binding >csubj >dobj Gene_or_gene_producttLe2: trigger-arg-path: complex >nn [lemma='smad4'] theme:Gene_or_gene_producttTe1: trigger-arg-path: binds:Binding >dobj [lemma='smad4'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] theme:Gene_or_gene_producttne1: trigger-arg-path: Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] theme:Gene_or_gene_productt@e2: trigger-arg-path: complex:Binding >nn [lemma='r-smad'] themet*shortest-path: dep >dobj >nntKe1: trigger-arg-path: binds:Binding >csubj >dobj theme:Gene_or_gene_productt?shortest-path: dep [lemma='form'] >dobj [lemma='complex'] >nn [lemma='r-smad']tXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smad4'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind >csubj >dobj themetJe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='r-smad'] themet7e2: trigger-arg-path: complex >nn [lemma='smad4'] themet_e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='r-smad'] theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='smad4'] Gene_or_gene_producttFe2: trigger-arg-path: complex >nn [lemma='smad4'] Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding >nn [lemma='smad4'] themetGe2: trigger-arg-path: Binding >nn [lemma='r-smad'] Gene_or_gene_productthtrigger-to-trigger-path: e1:binds:Binding >dep [lemma='form'] >dobj [lemma='complex'] e2:complex:Bindingt?e1: trigger-arg-path: Binding >csubj >dobj Gene_or_gene_producttte1: trigger-arg-path: binds:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] theme:Gene_or_gene_producttOe2: trigger-arg-path: complex:Binding >nn [lemma='r-smad'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind >csubj >dobj theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smad4'] theme:Gene_or_gene_producttle1: trigger-arg-path: binds >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='r-smad'] Gene_or_gene_productt6e1: trigger-arg-path: binds:Binding >csubj >dobj themet8e2: trigger-arg-path: complex >nn [lemma='r-smad'] themet`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smad4'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >dobj [lemma='smad4'] theme:Gene_or_gene_producttne1: trigger-arg-path: binds:Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=bind >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] themet0e1: trigger-arg-path: Binding >csubj >dobj themetUe2: trigger-arg-path: complex:Binding >nn [lemma='r-smad'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nn [lemma='r-smad'] themetGtrigger-to-trigger-path: e1:binds:Binding >dep >dobj e2:complex:BindingtNe2: trigger-arg-path: complex:Binding >nn [lemma='smad4'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='smad4'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=bind >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] Gene_or_gene_productt7e1: trigger-arg-path: binds >dobj [lemma='smad4'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='smad4'] themetGe2: trigger-arg-path: complex >nn [lemma='r-smad'] Gene_or_gene_productthe1: trigger-arg-path: Binding >csubj [lemma='phosphorylate'] >dobj [lemma='r-smad'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='smad4'] theme:Gene_or_gene_productt3e2: trigger-arg-path: increased >dobj Generic_eventt(e1: ents2Label-mention-ngram: Gbeta weret1e2: args2Role-mention-ngram: / Galphai CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controllertde1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galphaus'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >nn controller:Gene_or_gene_productthe2: trigger-arg-path: increased:Positive_regulation >dobj [lemma='association'] controlled:Generic_eventt/e2: args2Role-mention-ngram: Galphai CONTROLLEDt[e1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galphaus'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galphaus'] themet$e2: args2Role-mention-ngram: Galphait!e1: args2Role-mention-ngram: weretFe2: trigger-arg-path: increased >dobj [lemma='association'] controlledt,e1: ents2Label-mention-ngram: and Gbeta weret&e2: ents2Label-mention-ngram: IGF-1R /t?e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controller:Gene_or_gene_producttHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation increasedtpe2: trigger-arg-path: increased >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controller:Gene_or_gene_productt%interceding-tokens-full-span: , whilet>e2: trigger-arg-path: increased >dobj controlled:Generic_eventtAe2: trigger-arg-path: lemmatizedTrigger=increase >dobj controlledt'e2: ents2Label-mention-ngram: / Galphait+shortest-path: advcl >nsubj >nnt&e2: args2Role-mention-ngram: / Galphait1e1: args2Role-mention-ngram: were associated withtitrigger-to-trigger-path: e1:associated:Binding >advcl [lemma='increase'] e2:increased:Positive_regulationtoe2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn controllerte2: incoming: dobj [lemma='association'] controlledt,e1: args2Role-mention-ngram: were associatedt7e2: ents2Label-mention-ngram: stimulation increased thet3e2: args2Role-mention-ngram: CONTROLLER stimulationtle1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galphaus'] Gene_or_gene_productt=e2: args2Role-mention-ngram: CONTROLLER stimulation increasedtve2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] Gene_or_gene_producttRe2: trigger-arg-path: increased:Positive_regulation >dobj controlled:Generic_eventtre1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galphaus'] theme:Gene_or_gene_productte2: args2Role-mention-ngram: /tVe1: trigger-arg-path: Binding >nsubjpass [lemma='galphaus'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Positive_regulation >dobj Generic_eventt*e2: ents2Label-mention-ngram: the IGF-1R /t&e1: args2Role-mention-ngram: and GbetatWe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='association'] controlledtDe2: trigger-arg-path: increased:Positive_regulation >dobj controlledt(e2: ents2Label-mention-ngram: the IGF-1RtLe1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galphaus'] themet*e2: args2Role-mention-ngram: increased thetOe2: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:Generic_eventtne2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='association'] Generic_eventt2e2: args2Role-mention-ngram: stimulation increasedtIe2: trigger-arg-path: increased:Positive_regulation >nsubj >nn controllert?e2: trigger-arg-path: increased >nsubj >nn Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=increase >dobj Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controller:Gene_or_gene_productt5e2: trigger-arg-path: increased >nsubj >nn controllert'e2: args2Role-mention-ngram: the IGF-1Rt'e1: ents2Label-mention-ngram: and Gbetatee2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controllertye2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj Generic_eventtZe2: trigger-arg-path: increased:Positive_regulation >dobj [lemma='association'] controlledtoe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controllertSe2: trigger-arg-path: Positive_regulation >dobj [lemma='association'] Generic_eventt3e2: ents2Label-mention-ngram: / Galphai associationt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] Gene_or_gene_productt^e2: trigger-arg-path: increased:Positive_regulation >nsubj >nn controller:Gene_or_gene_productte2: ents2Label-mention-ngram: /tUe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj controlledt"e1: args2Role-mention-ngram: Gbetat0e2: trigger-arg-path: increased >dobj controlledtZe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >nn controllertIe2: trigger-arg-path: increased >dobj [lemma='association'] Generic_eventt+e2: ents2Label-mention-ngram: increased thetye2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='association'] controlled:Generic_eventt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulationt2e1: args2Role-mention-ngram: Gbeta were associatedt1e2: ents2Label-mention-ngram: Galphai associationte2: incoming: advcl e2:increased:Positive_regulationt[e2: trigger-arg-path: increased >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controllertPe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='galphaus'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: Gbeta were associatedt$e2: ents2Label-mention-ngram: IGF-1Rt"e1: ents2Label-mention-ngram: weretGe2: trigger-arg-path: increased:Positive_regulation >dobj Generic_eventt)e2: ents2Label-mention-ngram: associationt^e2: trigger-arg-path: Positive_regulation >dobj [lemma='association'] controlled:Generic_eventt-e1: ents2Label-mention-ngram: were associatedt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: IGF-1R / Galphait#e1: ents2Label-mention-ngram: Gbetatae1: trigger-arg-path: associated:Binding >nsubjpass [lemma='galphaus'] theme:Gene_or_gene_producttTe2: trigger-arg-path: increased >dobj [lemma='association'] controlled:Generic_eventt1e2: args2Role-mention-ngram: increased the IGF-1Rt+e1: args2Role-mention-ngram: and Gbeta weret)e2: args2Role-mention-ngram: the IGF-1R /tPe2: trigger-arg-path: Positive_regulation >dobj [lemma='association'] controlledtde2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >nn Gene_or_gene_productt2e2: ents2Label-mention-ngram: increased the IGF-1RtAe1: trigger-arg-path: Binding >nsubjpass [lemma='galphaus'] themet[e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn controller:Gene_or_gene_producttze2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controller:Gene_or_gene_producttxshortest-path: advcl [lemma='increase'] >nsubj [lemma='stimulation'] >nn [lemma='igf-1']t2e1: ents2Label-mention-ngram: were associated witht,e1: args2Role-mention-ngram: THEME and Gbetatee2: trigger-arg-path: increased >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] Gene_or_gene_productt-e2: args2Role-mention-ngram: IGF-1R / GalphaitYe1: trigger-arg-path: associated >nsubjpass [lemma='galphaus'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='association'] controlled:Generic_eventt6e2: args2Role-mention-ngram: stimulation increased thet%e2: ents2Label-mention-ngram: GalphaitPe1: trigger-arg-path: Binding >nsubjpass [lemma='galphaus'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='association'] Generic_eventtSe2: trigger-arg-path: increased:Positive_regulation >nsubj >nn Gene_or_gene_producttJe2: trigger-arg-path: increased >nsubj >nn controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >nn [lemma='igf-1'] controllert#e2: args2Role-mention-ngram: IGF-1Rtdobj controlled:Generic_eventtDe1: trigger-arg-path: associated >nsubjpass [lemma='galphaus'] themetHe2: trigger-arg-path: Positive_regulation >dobj controlled:Generic_eventt3e2: ents2Label-mention-ngram: stimulation increasedt;e1: ents2Label-mention-ngram: with the GENE_OR_GENE_PRODUCTt%e2: args2Role-mention-ngram: IGF-1R /tSe1: trigger-arg-path: associated >nsubjpass [lemma='galphaus'] Gene_or_gene_productt'e1: args2Role-mention-ngram: Gbeta weret]e2: trigger-arg-path: increased:Positive_regulation >dobj [lemma='association'] Generic_eventt]e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='galphaus'] themet,e2: args2Role-mention-ngram: both CONTROLLEDt4e1: args2Role-mention-ngram: partially restores bothtVe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj controller:Gene_or_gene_producttYe1: trigger-arg-path: restores:Positive_regulation >nsubj controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED partiallytIe2: trigger-arg-path: restores >nsubj [lemma='ggpp'] Gene_or_gene_productt]e2: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: partially restorest_e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt/e2: args2Role-mention-ngram: partially restorest'e2: ents2Label-mention-ngram: partiallythe1: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: partiallyt?e2: trigger-arg-path: restores >nsubj [lemma='ggpp'] controllert:e1: args2Role-mention-ngram: CONTROLLER partially restorest5e2: args2Role-mention-ngram: restores both CONTROLLEDt2e1: ents2Label-mention-ngram: both phosphorylationtTe2: trigger-arg-path: restores >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] controllert*e1: args2Role-mention-ngram: restores bothtPe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] controllertJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] controllert&e1: args2Role-mention-ngram: partiallyt;e2: ents2Label-mention-ngram: restores both phosphorylationt*e2: args2Role-mention-ngram: restores botht%e1: args2Role-mention-ngram: restorestde2: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] controllertTe1: trigger-arg-path: restores >nsubj [lemma='ggpp'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj controllertCshortest-path: advmod [lemma='partially']t&e1: ents2Label-mention-ngram: restorestee1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttEe1: trigger-arg-path: restores >nsubj controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: partiallyt.e1: ents2Label-mention-ngram: SHARED partiallytUe1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj controllertIe1: trigger-arg-path: restores >nsubj [lemma='ggpp'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: restores bothtJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] controllertde1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] controllert;e1: ents2Label-mention-ngram: restores both phosphorylationt5e1: ents2Label-mention-ngram: both phosphorylation oft1e1: args2Role-mention-ngram: CONTROLLER partiallyt4e2: args2Role-mention-ngram: partially restores botht/e1: args2Role-mention-ngram: partially restorestSe2: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] controllerte1: trigger: restorest:e2: args2Role-mention-ngram: CONTROLLER partially restorest7e2: ents2Label-mention-ngram: SHARED partially restorestye2: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj controller:Gene_or_gene_productt:e1: trigger-arg-path: restores >nsubj Gene_or_gene_productt5e1: ents2Label-mention-ngram: partially restores bothtTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: both phosphorylation oft_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: partially restorestNe1: trigger-arg-path: restores:Positive_regulation >nsubj Gene_or_gene_productt5e1: args2Role-mention-ngram: restores both CONTROLLEDt1e2: args2Role-mention-ngram: CONTROLLER partiallyt+e1: ents2Label-mention-ngram: restores bothtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt]e1: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: partially restores botht?e1: trigger-arg-path: restores >nsubj [lemma='ggpp'] controllert2e2: ents2Label-mention-ngram: both phosphorylationt7e1: ents2Label-mention-ngram: SHARED partially restorest0e1: trigger-arg-path: restores >nsubj controllertDe1: trigger-arg-path: restores:Positive_regulation >nsubj controllert,e1: args2Role-mention-ngram: both CONTROLLEDtKe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj Gene_or_gene_producttSe1: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] controllertZe2: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_productthe2: trigger-arg-path: restores:Positive_regulation >nsubj [lemma='ggpp'] controller:Gene_or_gene_producttge2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='cbp'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: familytNe1: trigger-arg-path: inhibits >nsubj [lemma='.1'] >nn [lemma='pu'] controllertSe2: trigger-arg-path: acetylation >nn [lemma='cbp'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='cbp'] Gene_or_gene_productt4e1: args2Role-mention-ngram: oncoproteins , inhibitst^e1: trigger-arg-path: inhibits >nsubj [lemma='.1'] >nn [lemma='pu'] controller:Simple_chemicalt'e1: ents2Label-mention-ngram: family oft*e1: ents2Label-mention-ngram: oncoproteinst6e1: ents2Label-mention-ngram: inhibits SHARED mediatedtee2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='cbp'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: GATA-1txe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] Simple_chemicalt%e1: ents2Label-mention-ngram: the Etst6e2: ents2Label-mention-ngram: transcription factor-1 (t$e1: ents2Label-mention-ngram: globint*e1: args2Role-mention-ngram: CONTROLLER .1t!e1: ents2Label-mention-ngram: Etst(e1: ents2Label-mention-ngram: , inhibitst$e1: args2Role-mention-ngram: the Etst+e2: ents2Label-mention-ngram: transcriptiont5e2: ents2Label-mention-ngram: mediated acetylation oft3e1: args2Role-mention-ngram: family of oncoproteinst2e2: ents2Label-mention-ngram: globin transcriptiont+e1: args2Role-mention-ngram: the Ets familyt/e1: ents2Label-mention-ngram: of oncoproteins ,t9e1: trigger-arg-path: inhibits >nsubj >nn Simple_chemicalt'e1: ents2Label-mention-ngram: member oftPe2: trigger-arg-path: Positive_regulation >nn [lemma='cbp'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='.1'] >nn [lemma='pu'] Simple_chemicalt4e2: ents2Label-mention-ngram: transcription factor-1t/e1: ents2Label-mention-ngram: factor-1 ( GATA-1t4e1: ents2Label-mention-ngram: family of oncoproteinst*e1: args2Role-mention-ngram: Ets family oft$e2: ents2Label-mention-ngram: globint*e1: ents2Label-mention-ngram: GATA-1 ) andtUe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Simple_chemicaltJe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn Simple_chemicalt'e2: ents2Label-mention-ngram: of globint'e1: args2Role-mention-ngram: , inhibitstHe2: trigger-arg-path: acetylation >nn [lemma='cbp'] Gene_or_gene_producttge1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] Simple_chemicaltatrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj e2:acetylation:Positive_regulationt e1: ents2Label-mention-ngram: .1t^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] Simple_chemicalt0e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL .1tMe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn Simple_chemicaltoe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='.1'] >nn [lemma='pu'] controller:Simple_chemicalt4e2: ents2Label-mention-ngram: ( GENE_OR_GENE_PRODUCTt$e1: ents2Label-mention-ngram: membert_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='.1'] >nn [lemma='pu'] controllertFe2: trigger-arg-path: Positive_regulation >nn [lemma='cbp'] controllert=e2: ents2Label-mention-ngram: factor-1 ( GENE_OR_GENE_PRODUCTt"e1: ents2Label-mention-ngram: .1 ,tXe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn controller:Simple_chemicaltZe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='cbp'] Gene_or_gene_producttYe1: trigger-arg-path: Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controllert+e1: ents2Label-mention-ngram: member of thet,e1: args2Role-mention-ngram: CONTROLLER .1 ,t(e1: ents2Label-mention-ngram: ( GATA-1 )tfshortest-path: dobj [lemma='acetylation'] >nn [lemma='cbp']t5e1: ents2Label-mention-ngram: of globin transcriptionte1: args2Role-mention-ngram: .1t%e1: args2Role-mention-ngram: a membert;e2: ents2Label-mention-ngram: globin transcription factor-1t2e1: ents2Label-mention-ngram: globin transcriptiont[e2: trigger-arg-path: Positive_regulation >nn [lemma='cbp'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: factor-1 (t,e1: ents2Label-mention-ngram: oncoproteins ,t$e1: ents2Label-mention-ngram: .1 , at,e1: args2Role-mention-ngram: of oncoproteinst4e1: ents2Label-mention-ngram: transcription factor-1t,e1: ents2Label-mention-ngram: the Ets familyt2e1: args2Role-mention-ngram: , inhibits CONTROLLEDt3e1: ents2Label-mention-ngram: acetylation of globint'e1: ents2Label-mention-ngram: of globint5e2: ents2Label-mention-ngram: of globin transcriptiontre1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controller:Simple_chemicalt)e1: args2Role-mention-ngram: oncoproteinst;e1: ents2Label-mention-ngram: globin transcription factor-1t&e1: ents2Label-mention-ngram: GATA-1 )t#e1: args2Role-mention-ngram: membert*e1: args2Role-mention-ngram: member of thetie1: trigger-arg-path: Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controller:Simple_chemicaltie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn controller:Simple_chemicalt e1: args2Role-mention-ngram: Etst&e1: ents2Label-mention-ngram: ( GATA-1t>e2: trigger-arg-path: acetylation >nn [lemma='cbp'] controllert5e1: ents2Label-mention-ngram: oncoproteins , inhibitst&e1: ents2Label-mention-ngram: a membert)e1: ents2Label-mention-ngram: a member oft?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controller:Simple_chemicalt.e1: args2Role-mention-ngram: of oncoproteins ,tde2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='cbp'] controllertye2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='cbp'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: familyt'e1: args2Role-mention-ngram: of the Etst#e1: args2Role-mention-ngram: .1 , at3e2: ents2Label-mention-ngram: acetylation of globint+e1: ents2Label-mention-ngram: Ets family oftSe1: trigger-arg-path: inhibits >nsubj [lemma='.1'] >nn [lemma='pu'] Simple_chemicalt&e1: args2Role-mention-ngram: member oft!e1: args2Role-mention-ngram: .1 ,t'e1: args2Role-mention-ngram: , a membert-e1: ents2Label-mention-ngram: of oncoproteinst\e2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='cbp'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: Ets familyt(e1: ents2Label-mention-ngram: of the Etstwtrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj [lemma='acetylation'] e2:acetylation:Positive_regulationt(e1: ents2Label-mention-ngram: factor-1 (t6e1: ents2Label-mention-ngram: transcription factor-1 (t+e1: args2Role-mention-ngram: oncoproteins ,t e1: args2Role-mention-ngram: , at(e1: ents2Label-mention-ngram: , a membertPe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='cbp'] controllert2e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL .1 ,t&e1: ents2Label-mention-ngram: factor-1t^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn Simple_chemicalt(e1: args2Role-mention-ngram: a member oft5e1: ents2Label-mention-ngram: mediated acetylation oftse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controllertRe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='cbp'] controllertDe1: trigger-arg-path: inhibits >nsubj >nn controller:Simple_chemicalt'e1: args2Role-mention-ngram: Ets familytbe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='.1'] >nn [lemma='pu'] controllert/e1: ents2Label-mention-ngram: , inhibits SHAREDt&e2: ents2Label-mention-ngram: factor-1t&e1: args2Role-mention-ngram: family oft_e1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='this'] controller:Generic_entitytde1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj controller:Generic_entitytne2: trigger-arg-path: initiates:Positive_regulation >prep_by [lemma='complex'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation prep_by [lemma='complex'] controllertce2: trigger-arg-path: initiates:Positive_regulation >prep_by [lemma='complex'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=initiate >prep_by Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj [lemma='this'] controllert,e2: args2Role-mention-ngram: of the membranetge2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation nsubj controller:Generic_entityt,e2: ents2Label-mention-ngram: via nucleationtYe1: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >nsubj Generic_entityt+e2: args2Role-mention-ngram: via nucleationte2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation >prep_by [lemma='complex'] controller:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation >prep_by [lemma='complex'] Gene_or_gene_productt*e2: args2Role-mention-ngram: elongation oftJe1: trigger-arg-path: Positive_regulation >nsubj controller:Generic_entityt&e2: args2Role-mention-ngram: initiatestCe1: trigger-arg-path: recruits >nsubj [lemma='this'] Generic_entityt.e2: args2Role-mention-ngram: and initiates thet'e2: ents2Label-mention-ngram: initiatestIe2: trigger-arg-path: initiates prep_by controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation >prep_by Gene_or_gene_productt-e2: args2Role-mention-ngram: via nucleation ,t>e2: trigger-arg-path: Positive_regulation nsubj [lemma='this'] controller:Generic_entitytPe2: trigger-arg-path: Positive_regulation nsubj Generic_entitythe2: trigger-arg-path: initiates:Positive_regulation nsubj [lemma='this'] Generic_entitytke2: trigger-arg-path: lemmatizedTrigger=initiate >prep_by [lemma='complex'] controller:Gene_or_gene_productt3e2: trigger-arg-path: initiates >prep_by controllertOe2: trigger-arg-path: initiates >prep_by [lemma='complex'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=initiate prep_by [lemma='complex'] controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: GENERIC_ENTITY recruitst+e2: ents2Label-mention-ngram: elongation oft-e2: ents2Label-mention-ngram: to the membranet,e2: ents2Label-mention-ngram: the membrane ,tKe2: trigger-arg-path: initiates:Positive_regulation prep_by controller:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=initiate >prep_by controllert,e2: args2Role-mention-ngram: , and initiatestOe2: trigger-arg-path: Positive_regulation >prep_by [lemma='complex'] controllert&e2: ents2Label-mention-ngram: recruitst"e2: args2Role-mention-ngram: , viat%e2: ents2Label-mention-ngram: furthert-e2: args2Role-mention-ngram: CONTROLLED , viat\e2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation prep_by controller:Gene_or_gene_producttLe2: trigger-arg-path: Positive_regulation prep_by [lemma='complex'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: the membrane byt.e2: args2Role-mention-ngram: elongation of thetbe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='this'] controller:Generic_entityt%e1: ents2Label-mention-ngram: furthert'e2: args2Role-mention-ngram: elongationt*e2: args2Role-mention-ngram: initiates thet.e1: ents2Label-mention-ngram: recruits furthert*e2: args2Role-mention-ngram: and initiatestEe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj Generic_entityt*e2: ents2Label-mention-ngram: the membranet=e1: ents2Label-mention-ngram: GENERIC_ENTITY recruits furthert/e2: ents2Label-mention-ngram: and initiates thet-e2: ents2Label-mention-ngram: membrane by thetEe2: trigger-arg-path: initiates >prep_by [lemma='complex'] controllertSe2: trigger-arg-path: Positive_regulation nsubj [lemma='this'] controller:Generic_entitytVe2: trigger-arg-path: lemmatizedTrigger=initiate >prep_by [lemma='complex'] controllert7e2: trigger-arg-path: initiates prep_by controllertctrigger-to-trigger-path: e1:recruits:Positive_regulation >conj_and e2:initiates:Positive_regulationtZe2: trigger-arg-path: lemmatizedTrigger=initiate nsubj [lemma='this'] controllertPe1: trigger-arg-path: lemmatizedTrigger=recruit >nsubj [lemma='this'] controllertBe2: trigger-arg-path: initiates nsubj controller:Generic_entityt+e2: args2Role-mention-ngram: the elongationt/e2: ents2Label-mention-ngram: elongation of thet+e2: ents2Label-mention-ngram: and initiatest+e2: ents2Label-mention-ngram: initiates thetye2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation nsubj Generic_entityt?e1: trigger-arg-path: Positive_regulation >nsubj Generic_entitytne2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation prep_by [lemma='complex'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=initiate:Positive_regulation >prep_by controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: the elongation oft)e2: args2Role-mention-ngram: the membranetHe2: trigger-arg-path: initiates:Positive_regulation conj_and [lemma='initiate'] e2:initiates:Positive_regulationt,e2: args2Role-mention-ngram: the membrane bytYe2: trigger-arg-path: initiates:Positive_regulation >prep_by [lemma='complex'] controllert,e2: args2Role-mention-ngram: membrane by thet4e2: trigger-arg-path: initiates prep_by Gene_or_gene_productt?e1: trigger-arg-path: recruits >nsubj [lemma='this'] controllertWe2: trigger-arg-path: lemmatizedTrigger=initiate prep_by controllertWe1: trigger-arg-path: recruits:Positive_regulation >nsubj [lemma='this'] Generic_entitytSe1: trigger-arg-path: recruits:Positive_regulation >nsubj controller:Generic_entityt]e2: trigger-arg-path: initiates:Positive_regulation nsubj [lemma='this'] Generic_entityt(e2: ents2Label-mention-ngram: nucleationtYe2: trigger-arg-path: Positive_regulation >prep_by [lemma='complex'] Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='this'] Generic_entitytHe2: trigger-arg-path: lemmatizedTrigger=initiate nsubj [lemma='this'] controller:Generic_entityt=e2: trigger-arg-path: initiates >prep_by Gene_or_gene_productt-e2: args2Role-mention-ngram: , via nucleationtJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='this'] controllert*e2: ents2Label-mention-ngram: nucleation ,tFe2: trigger-arg-path: initiates nsubj [lemma='ra'] themet*e1: args2Role-mention-ngram: and activatedtje1: trigger-arg-path: binds >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: activates the SHAREDt%e1: ents2Label-mention-ngram: Raf andt{e1: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] Gene_or_gene_productt$e1: args2Role-mention-ngram: Raf andtte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] themet[e1: trigger-arg-path: binds >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] themetFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] themet7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , intYtrigger-to-trigger-path: e1:binds:Binding >conj_and e2:phosphorylates:Positive_regulationt"e1: args2Role-mention-ngram: Raf ,t$e1: ents2Label-mention-ngram: turn ,t=e1: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] themet!e2: args2Role-mention-ngram: , int#e1: ents2Label-mention-ngram: Raf ,t$e2: ents2Label-mention-ngram: turn ,t$e1: ents2Label-mention-ngram: of Raft.e1: args2Role-mention-ngram: Raf and activatedt+e1: ents2Label-mention-ngram: activated Raft?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: , in turnt/e1: ents2Label-mention-ngram: and activated Raft&e1: args2Role-mention-ngram: , in turnt)e2: args2Role-mention-ngram: , CONTROLLEDt/e1: args2Role-mention-ngram: promote activationt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='raf'] controller:Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='ra'] Familytnsubj [lemma='ra'] theme:Familyt,e1: args2Role-mention-ngram: activated Raf ,tje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='raf'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: promote activationt&e2: args2Role-mention-ngram: , in turnt.e1: ents2Label-mention-ngram: , phosphorylatest1e1: args2Role-mention-ngram: , phosphorylates andt!e1: ents2Label-mention-ngram: Raftme2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='raf'] controller:Gene_or_gene_producttqtrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationt]e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] themetpe1: trigger-arg-path: binds >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] theme:Gene_or_gene_producttce1: trigger-arg-path: binds:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] themetSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='raf'] Gene_or_gene_productt.e2: args2Role-mention-ngram: turn , CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] theme:Gene_or_gene_producttle1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: activates the SHAREDt"e1: ents2Label-mention-ngram: , int,e1: ents2Label-mention-ngram: to and promotet>e1: trigger-arg-path: Binding >nsubj [lemma='ra'] theme:Familyt#e1: args2Role-mention-ngram: turn ,tle1: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] themet&e2: args2Role-mention-ngram: in turn ,tre1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] theme:Gene_or_gene_producttVshortest-path: conj_and [lemma='activate'] >nsubj [lemma='raf']t#e1: args2Role-mention-ngram: of Raft#e2: args2Role-mention-ngram: turn ,t'e2: ents2Label-mention-ngram: in turn ,tre1: trigger-arg-path: binds:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] Gene_or_gene_productt-e1: args2Role-mention-ngram: , phosphorylatestYe2: trigger-arg-path: phosphorylates >nsubj [lemma='raf'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: Raf , int_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='raf'] Gene_or_gene_productt.e1: args2Role-mention-ngram: activation of Raft"e2: ents2Label-mention-ngram: , int'e1: ents2Label-mention-ngram: , in turnt2e2: ents2Label-mention-ngram: , phosphorylates andt&e1: ents2Label-mention-ngram: Raf , int e1: args2Role-mention-ngram: Raft/e1: ents2Label-mention-ngram: Raf and activatedtMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] theme:Familyt+e1: ents2Label-mention-ngram: and activatedt*e1: args2Role-mention-ngram: activated Raft&e1: args2Role-mention-ngram: in turn ,t7e1: trigger-arg-path: Binding >nsubj [lemma='ra'] themet3e1: args2Role-mention-ngram: and promote activationt5e1: trigger-arg-path: binds >nsubj [lemma='ra'] themetUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='raf'] controllert,e2: args2Role-mention-ngram: CONTROLLER , int'e1: args2Role-mention-ngram: of Raf andtxe1: trigger-arg-path: binds:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='raf'] controllert^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='raf'] controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ra'] theme:Familyt4e1: ents2Label-mention-ngram: and promote activationt0e1: args2Role-mention-ngram: activates the THEMEt'e1: ents2Label-mention-ngram: in turn ,t-e1: ents2Label-mention-ngram: activated Raf ,t8e1: trigger-arg-path: Binding >nsubj [lemma='ra'] FamilytDe1: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] theme:Familytse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='raf'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: of Raf andt2e1: args2Role-mention-ngram: promote activation oft.e1: args2Role-mention-ngram: and activated Raft.e2: ents2Label-mention-ngram: , phosphorylatest?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='mitogen'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='ra'] Familyt+e1: args2Role-mention-ngram: to and promotet3e1: ents2Label-mention-ngram: promote activation oftNe2: trigger-arg-path: phosphorylates >nsubj [lemma='raf'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: , phosphorylates andtXe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='raf'] controllertGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ra'] Familytie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='raf'] controllert2e1: args2Role-mention-ngram: turn , phosphorylatest/e1: ents2Label-mention-ngram: activation of Raft!e1: args2Role-mention-ngram: , int3e2: ents2Label-mention-ngram: turn , phosphorylatestOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ra'] Familyt-e1: ents2Label-mention-ngram: FAMILY binds tot3e1: ents2Label-mention-ngram: turn , phosphorylatestbe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='raf'] Gene_or_gene_producttDe2: trigger-arg-path: phosphorylates >nsubj [lemma='raf'] controllertle2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_productt#e2: args2Role-mention-ngram: ) , tot.e2: ents2Label-mention-ngram: ERalpha mediatedt)e2: args2Role-mention-ngram: , to inhibittee2: trigger-arg-path: inhibit nsubjpass [lemma='TAF-1beta'] controlled:BindingtCe2: trigger-arg-path: Negative_regulation nsubjpass Bindingt)e2: ents2Label-mention-ngram: the ERalphatoe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='TAF-1beta'] controlledt/e2: ents2Label-mention-ngram: the activation oft+e2: ents2Label-mention-ngram: with SHARED (t?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] Bindingt'e2: ents2Label-mention-ngram: ( ERalphat^e2: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_productt&e2: args2Role-mention-ngram: ( ERalphat-e2: args2Role-mention-ngram: of transcriptiont?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] controlledt"e2: ents2Label-mention-ngram: , totEe2: trigger-arg-path: inhibit:Negative_regulation >prep_by controllertZe2: trigger-arg-path: inhibit nsubjpass [lemma='TAF-1beta'] Bindingt4e2: ents2Label-mention-ngram: ERalpha acetylation byt0e2: args2Role-mention-ngram: mediated activationtfe2: trigger-arg-path: Negative_regulation nsubjpass [lemma='TAF-1beta'] BindingtWe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by controllert`e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass controlledt3e2: args2Role-mention-ngram: inhibit the activationt%e2: ents2Label-mention-ngram: ERalphatXe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: ERalpha ) ,tie2: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: and to inhibitt,e2: ents2Label-mention-ngram: and to inhibittTe2: trigger-arg-path: inhibit:Negative_regulation >prep_by [lemma='p300'] controllertUe2: trigger-arg-path: inhibit >prep_by [lemma='p300'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: ERalpha acetylationt:e2: trigger-arg-path: inhibit nsubjpass controlledtFe2: trigger-arg-path: inhibit >prep_by controller:Gene_or_gene_productt=e2: trigger-arg-path: Negative_regulation >prep_by controllert)e2: ents2Label-mention-ngram: inhibit thet9e2: ents2Label-mention-ngram: activation of transcriptiont1e2: args2Role-mention-ngram: CONTROLLED ( ERalphat3e2: ents2Label-mention-ngram: activation of ERalphatNe2: trigger-arg-path: inhibit:Negative_regulation nsubjpass controlledt(e2: args2Role-mention-ngram: inhibit thet4e2: ents2Label-mention-ngram: mediated activation oft1e2: args2Role-mention-ngram: the ERalpha mediatedt&e2: args2Role-mention-ngram: ERalpha )the2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass controlled:BindingtZe2: trigger-arg-path: inhibit:Negative_regulation >prep_by controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: and tot'e2: ents2Label-mention-ngram: ERalpha )t(e2: args2Role-mention-ngram: the ERalphat3e2: args2Role-mention-ngram: of ERalpha acetylationt'e2: args2Role-mention-ngram: to inhibitt$e2: args2Role-mention-ngram: ERalphat-e2: args2Role-mention-ngram: ERalpha mediatedt2e2: ents2Label-mention-ngram: the ERalpha mediatedt(e2: args2Role-mention-ngram: ERalpha ) ,tFe2: trigger-arg-path: Negative_regulation nsubjpass controlledtRe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] controllert]e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass Bindingtye2: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] controlled:Bindingt]e2: trigger-arg-path: inhibit nsubjpass [lemma='TAF-1beta'] controlledtqe2: trigger-arg-path: Negative_regulation nsubjpass [lemma='TAF-1beta'] controlled:BindingtUtrigger-to-trigger-path: e1:interact:Binding >conj_and e2:inhibit:Negative_regulationt1e2: trigger-arg-path: inhibit >prep_by controllert(e2: ents2Label-mention-ngram: to inhibitt\e2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] Gene_or_gene_producttNe2: trigger-arg-path: Negative_regulation nsubjpass controlled:Bindingt9e2: ents2Label-mention-ngram: ERalpha mediated activationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] controlled:Bindingt-e2: ents2Label-mention-ngram: transcription ,tRe2: trigger-arg-path: Negative_regulation >prep_by controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: transcription , andtIe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass Bindingt1e2: ents2Label-mention-ngram: inhibit the ERalphatOe2: trigger-arg-path: inhibit:Negative_regulation >prep_by Gene_or_gene_productt#e2: args2Role-mention-ngram: and totTe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass controlled:Bindingt+e2: args2Role-mention-ngram: the activationt%e2: args2Role-mention-ngram: , and tot,e2: ents2Label-mention-ngram: the activationtfe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] controllert(e2: ents2Label-mention-ngram: of ERalphatae2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by Gene_or_gene_producttGe2: trigger-arg-path: Negative_regulation >prep_by Gene_or_gene_producttJe2: trigger-arg-path: inhibit >prep_by [lemma='p300'] Gene_or_gene_productt0e2: args2Role-mention-ngram: ERalpha acetylationt0e2: args2Role-mention-ngram: inhibit the ERalphat4e2: ents2Label-mention-ngram: inhibit the activationt)e2: ents2Label-mention-ngram: ( ERalpha )t-e2: ents2Label-mention-ngram: SHARED and pp32t7e2: trigger-arg-path: inhibit nsubjpass BindingtLe2: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] controllertge2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by [lemma='p300'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: of transcription ,tae2: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_productt@e2: trigger-arg-path: inhibit >prep_by [lemma='p300'] controllert0e2: args2Role-mention-ngram: transcription , andt'e2: args2Role-mention-ngram: of ERalphatne2: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] Bindingt8e2: args2Role-mention-ngram: activation of transcriptiont3e2: args2Role-mention-ngram: ERalpha acetylation byt/e2: args2Role-mention-ngram: of transcription ,t2e2: args2Role-mention-ngram: activation of ERalphat!e2: args2Role-mention-ngram: , totLe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass controlledtwe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='TAF-1beta'] controlled:Bindingt$e2: ents2Label-mention-ngram: ) , tot*e2: ents2Label-mention-ngram: , to inhibitt&e2: ents2Label-mention-ngram: , and tot+e2: args2Role-mention-ngram: acetylation bytgtrigger-to-trigger-path: e1:interact:Binding >conj_and [lemma='inhibit'] e2:inhibit:Negative_regulationtVe2: trigger-arg-path: inhibit:Negative_regulation nsubjpass controlled:Bindingt,e2: args2Role-mention-ngram: transcription ,tle2: trigger-arg-path: lemmatizedTrigger=inhibit nsubjpass [lemma='TAF-1beta'] Bindingt{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >prep_by [lemma='p300'] controller:Gene_or_gene_producttVe2: trigger-arg-path: Negative_regulation >prep_by [lemma='p300'] Gene_or_gene_productt;e2: trigger-arg-path: inhibit >prep_by Gene_or_gene_producttie2: trigger-arg-path: Negative_regulation nsubjpass [lemma='TAF-1beta'] controlledt1e2: ents2Label-mention-ngram: mediated activationt+e2: args2Role-mention-ngram: to inhibit thetqe2: trigger-arg-path: inhibit:Negative_regulation nsubjpass [lemma='TAF-1beta'] controlledt,e2: ents2Label-mention-ngram: to inhibit thet3e2: args2Role-mention-ngram: mediated activation oft6e2: args2Role-mention-ngram: acetylation by CONTROLLERt8e2: args2Role-mention-ngram: ERalpha mediated activationtBe2: trigger-arg-path: inhibit nsubjpass controlled:Bindingt.e2: ents2Label-mention-ngram: of transcriptiont.e2: args2Role-mention-ngram: the activation oft4e2: ents2Label-mention-ngram: of ERalpha acetylationt(e2: args2Role-mention-ngram: ( ERalpha )tMe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=inhibit >prep_by controllertKe2: trigger-arg-path: inhibit:Negative_regulation nsubjpass Bindingt.e2: ents2Label-mention-ngram: SHARED ( ERalphat*e2: args2Role-mention-ngram: transcriptiont-e1: ents2Label-mention-ngram: SHARED and pp32t e1: args2Role-mention-ngram: PAKt~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation prep_to >amod e2:activated:Positive_regulationt%e1: ents2Label-mention-ngram: mbt ) ,tTe2: trigger-arg-path: activated ccompt=e2: trigger-arg-path: activated ccompt1e2: ents2Label-mention-ngram: which phosphorylatet'e1: args2Role-mention-ngram: ) proteinst#e2: ents2Label-mention-ngram: ( Pakt+e1: args2Role-mention-ngram: PAK ) proteinst*e2: ents2Label-mention-ngram: ) proteins (t.e2: ents2Label-mention-ngram: activated kinaset3e2: args2Role-mention-ngram: CONTROLLED in responset)e1: ents2Label-mention-ngram: Pak and mbtt/e1: args2Role-mention-ngram: , which CONTROLLEDt?trigger-to-trigger-path: e1:phosphorylate:Positive_regulation >prep_to [lemma='ra'] >amod [lemma='activate'] e2:activated:Positive_regulationtJe2: trigger-arg-path: Positive_regulation nsubj [lemma='ampk'] Gene_or_gene_productt=e1: trigger-arg-path: activate >dobj [lemma='p53'] controlledt]e1: trigger-arg-path: activate:Positive_activation parataxis [lemma='phosphorylate'] e2:phosphorylates:Positive_regulationtOe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p53'] controlledtee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation dobj [lemma='p53'] Gene_or_gene_producttIe1: trigger-arg-path: activate nsubj [lemma='ampk'] controllertJe1: trigger-arg-path: Positive_activation parataxis [lemma='phosphorylate'] >nsubj [lemma='ampk']tVe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='ampk'] controllertke1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation dobj [lemma='p53'] controlled:Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED whicht_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ampk'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ampk'] controllertRe1: trigger-arg-path: activate >dobj [lemma='p53'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: activate:Positive_activation dobj [lemma='p53'] controlledtne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ampk'] controller:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ampk'] controllert0e1: args2Role-mention-ngram: CONTROLLER which int%e1: args2Role-mention-ngram: turn cantEe1: trigger-arg-path: Positive_activation dobj [lemma='p53'] Gene_or_gene_producttHe1: trigger-arg-path: Positive_activation >dobj [lemma='p53'] controlledte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ampk'] controller:Gene_or_gene_productt]e1: trigger-arg-path: Positive_activation >dobj [lemma='p53'] controlled:Gene_or_gene_producttce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ampk'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p53'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ampk'] controllert)e1: ents2Label-mention-ngram: in turn cantDe1: trigger-arg-path: activate:Positive_activation nsubj [lemma='ampk'] controller:Gene_or_gene_producttTe1: trigger-arg-path: activate dobj [lemma='p53'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ampk'] Gene_or_gene_productt[e1: trigger-arg-path: activate:Positive_activation >dobj [lemma='p53'] Gene_or_gene_producttYe1: trigger-arg-path: activate:Positive_activation parataxis >nsubjtvtrigger-to-trigger-path: e1:activate:Positive_activation parataxis e2:phosphorylates:Positive_regulationtce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p53'] controlledt(e1: args2Role-mention-ngram: in turn cant_e1: trigger-arg-path: Positive_activation dobj [lemma='p53'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='ampk'] controller:Gene_or_gene_producttPe1: trigger-arg-path: Positive_activation dobj [lemma='p53'] controlled:Gene_or_gene_producttOe2: trigger-arg-path: phosphorylates >nsubj [lemma='ampk'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ampk'] Gene_or_gene_productt0e1: trigger-arg-path: activate prep_of [lemma='caspase-8'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: and activationt7e1: args2Role-mention-ngram: recruitment and activationt@e2: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] themet,e1: args2Role-mention-ngram: recruitment andtDe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] themetae2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: recruitment and activationt-e2: ents2Label-mention-ngram: recruitment andtee2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-8'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] themetAe1: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] themet.e2: args2Role-mention-ngram: and activation oft,e2: args2Role-mention-ngram: recruitment andtle2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] theme:Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] themetSe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: and activationt\e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_productt\e1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] Gene_or_gene_producttYe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] theme:Gene_or_gene_producttEe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] themetYe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] theme:Gene_or_gene_producttVe2: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] Gene_or_gene_producttAe2: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] themet_e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] themetVe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-8'] themetWe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] themetVe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-8'] themetme1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: recruitment andtMe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] themetMe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] themetbe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: and activation oftne2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] Gene_or_gene_productt0e1: args2Role-mention-ngram: activation of THEMEtSe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] Gene_or_gene_productt[e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] Gene_or_gene_producttbe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_producttZe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-8'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_productt8e2: ents2Label-mention-ngram: recruitment and activationtke1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-8'] theme:Gene_or_gene_productt[e1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] Gene_or_gene_producttTe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] Gene_or_gene_producttLe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] themetZe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_of [lemma='caspase-10'] Gene_or_gene_productt7e2: args2Role-mention-ngram: recruitment and activationt0e2: args2Role-mention-ngram: activation of THEMEtae1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_producttDe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-8'] themetUe2: trigger-arg-path: Binding >prep_of [lemma='caspase-8'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] themetLe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='caspase-8'] themetEe2: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] themetWe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='caspase-10'] themetTe1: trigger-arg-path: recruitment >prep_of [lemma='caspase-10'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-10'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='caspase-8'] themetLe2: trigger-arg-path: interaction:Binding >prep_between theme:Generic_entityt9e1: trigger-arg-path: binds >prep_to [lemma='fip1'] themetEe1: trigger-arg-path: binds >nsubj [lemma='Rab'] Gene_or_gene_producttwshortest-path: ccomp [lemma='control'] >nsubj [lemma='interaction']t"interceding-token ngrams: RCP , itt&interceding-token ngrams: hypothesizedtPe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between Generic_entityt'e1: ents2Label-mention-ngram: SHARED 25tMe1: trigger-arg-path: Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_between [lemma='they'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_producttinterceding-token ngrams: RCPtUe2: trigger-arg-path: interaction:Binding >prep_between [lemma='they'] Generic_entitytDe2: trigger-arg-path: interaction >prep_between theme:Generic_entitytIe2: trigger-arg-path: Binding >prep_between [lemma='they'] Generic_entitytHe1: trigger-arg-path: binds >prep_to [lemma='fip1'] Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='Rab'] themet?trigger-to-trigger-path: e1:binds:Binding ccomp [lemma='control'] >nsubj [lemma='interaction'] e2:interaction:Bindingt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between theme:Generic_entitytae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='fip1'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='fip1'] themetKe1: trigger-arg-path: binds >nsubj [lemma='Rab'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: 25 binds tot^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='they'] Generic_entityt)interceding-token ngrams: is hypothesizedtJe1: trigger-arg-path: Binding >prep_to [lemma='fip1'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='they'] theme:Generic_entitytme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='they'] theme:Generic_entityt,interceding-token ngrams: it is hypothesizedtinterceding-token ngrams: RCP ,t e1: ents2Label-mention-ngram: 25tRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='fip1'] themetLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='they'] themetMe1: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] Gene_or_gene_productt!interceding-token ngrams: and RCPtSe2: trigger-arg-path: interaction >prep_between [lemma='they'] theme:Generic_entityt8e1: trigger-arg-path: Binding >nsubj [lemma='Rab'] themete1: args2Role-mention-ngram: 25t(e1: args2Role-mention-ngram: 25 binds totVe1: trigger-arg-path: binds:Binding >prep_to [lemma='fip1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='fip1'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='fip1'] theme:Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='Rab'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED 25 bindst>e1: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] themet^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='they'] themet%e1: args2Role-mention-ngram: 25 bindstXe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between Generic_entitytge2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='they'] Generic_entityt&e1: ents2Label-mention-ngram: 25 bindstVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between theme:Generic_entityt[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='they'] theme:Generic_entitytDe2: trigger-arg-path: interaction >prep_between [lemma='they'] themetAe1: trigger-arg-path: binds:Binding >prep_to [lemma='fip1'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='fip1'] themetUtrigger-to-trigger-path: e1:binds:Binding ccomp >nsubj e2:interaction:Bindingt+e1: args2Role-mention-ngram: THEME 25 bindst*shortest-path: ccomp >nsubjt+interceding-token ngrams: hypothesized thatt#interceding-token ngrams: and RCP ,t@e2: trigger-arg-path: Binding >prep_between theme:Generic_entityt%e1: args2Role-mention-ngram: THEME 25tFe2: trigger-arg-path: interaction:Binding >prep_between Generic_entitytSe1: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_productt:e2: trigger-arg-path: Binding >prep_between Generic_entitytNe1: trigger-arg-path: binds >prep_to [lemma='fip1'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interaction >prep_between [lemma='they'] Generic_entitytPe1: trigger-arg-path: binds:Binding >prep_to [lemma='fip1'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] Gene_or_gene_productt>e2: trigger-arg-path: interaction >prep_between Generic_entitytVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='they'] themetOe2: trigger-arg-path: Binding >prep_between [lemma='they'] theme:Generic_entityt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='fip1'] theme:Gene_or_gene_productt.interceding-token ngrams: is hypothesized thattOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] themet?interceding-tokens-full-span: and RCP , it is hypothesized thattPe1: trigger-arg-path: Binding >prep_to [lemma='fip1'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binding:Binding prep_to Gene_or_gene_productt0e1: trigger-arg-path: binding:Binding >nn FamilytOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] Familyt?e1: trigger-arg-path: binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] Gene_or_gene_productt5e1: trigger-arg-path: binding >nn [lemma='ra'] FamilytBe2: ents2Label-mention-ngram: suppressed this GENE_OR_GENE_PRODUCTt(shortest-path: nsubjt=e1: trigger-arg-path: binding:Binding >nn [lemma='ra'] FamilytHe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_productt6e1: trigger-arg-path: binding:Binding >nn theme:Familyt?e1: trigger-arg-path: Binding prep_to [lemma='raf1'] Gene_or_gene_productt(e1: trigger-arg-path: binding >nn FamilytMe1: trigger-arg-path: lemmatizedTrigger=binding prep_to themetBe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn FamilytJe1: trigger-arg-path: binding prep_to Gene_or_gene_producttoshortest-path: nsubj [lemma='ca']tPe1: trigger-arg-path: binding prep_to theme:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=binding >nn theme:FamilytUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] theme:Familyt4e1: trigger-arg-path: binding >nn [lemma='ra'] themet;e1: trigger-arg-path: binding prep_to themet7e2: ents2Label-mention-ngram: this GENE_OR_GENE_PRODUCTt.e1: trigger-arg-path: binding >nn theme:Familytde1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] themetMe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] theme:Familytze1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] themetre1: trigger-arg-path: binding prep_to [lemma='raf1'] themetCe1: trigger-arg-path: binding:Binding prep_to themetJe1: trigger-arg-path: Binding prep_to Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='ra'] themetXe1: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_productt:e1: trigger-arg-path: lemmatizedTrigger=binding >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt\trigger-to-trigger-path: e1:binding:Binding prep_to Gene_or_gene_producttre1: trigger-arg-path: Binding prep_to [lemma='raf1'] themetPe1: trigger-arg-path: Binding prep_to theme:Gene_or_gene_productt;e1: trigger-arg-path: binding >nn [lemma='ra'] theme:Familyt?e1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt?trigger-to-trigger-path: e1:binding:Binding nn [lemma='ra'] themet?e1: trigger-arg-path: binding prep_to [lemma='raf1'] Gene_or_gene_producttCe1: trigger-arg-path: binding:Binding >nn [lemma='ra'] theme:Familyt;e1: trigger-arg-path: Binding prep_to themet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] themetGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] FamilytFe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='ra'] themetBe2: ents2Label-mention-ngram: this GENE_OR_GENE_PRODUCT inhibitiont?e1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttoe2: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: the conversiontXe1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj controllert3e1: trigger-arg-path: inactivates >nsubj controllertEe1: trigger-arg-path: Negative_regulation >prepc_by >ccomp controlledtNe1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj Gene_or_gene_productt=e1: trigger-arg-path: inactivates >nsubj Gene_or_gene_productthe1: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] Bindingtoe2: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt^e1: trigger-arg-path: inactivates >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] BindingtQe1: trigger-arg-path: inactivates:Negative_regulation >nsubj Gene_or_gene_productt)e2: args2Role-mention-ngram: inactive GDPtie1: trigger-arg-path: inactivates >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlled:Bindingt-e1: ents2Label-mention-ngram: inactivates Rast!e2: ents2Label-mention-ngram: GDPtze1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlled:Bindingt/e1: ents2Label-mention-ngram: of active Ras-GTPt`e1: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: GDP bound THEMEt]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_producttae1: trigger-arg-path: inactivates >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlledt/e1: ents2Label-mention-ngram: active Ras-GTP totKe1: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] controllert?e1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] Bindingtme1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:inactivates:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] e2:bound:Bindingtxe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_productt(e1: args2Role-mention-ngram: inactivatest`e2: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themetSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] controllert+e1: ents2Label-mention-ngram: conversion oftBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inactivates RastZe2: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themet\e1: trigger-arg-path: inactivates:Negative_regulation >nsubj controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt e2: args2Role-mention-ngram: GDPt?e1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlled:Bindingt(e1: ents2Label-mention-ngram: conversiont)e2: ents2Label-mention-ngram: to inactivetDe1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj controllert0e2: ents2Label-mention-ngram: inactive GDP boundt\e1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] controllert/e2: args2Role-mention-ngram: inactive GDP boundt1e1: ents2Label-mention-ngram: Ras-GTP to inactivetMe1: trigger-arg-path: Negative_regulation >prepc_by >ccomp controlled:Bindingt.e2: ents2Label-mention-ngram: GDP bound SHAREDtje1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by >ccomp controlled:Bindingt9e1: ents2Label-mention-ngram: accelerating the conversiont.e1: args2Role-mention-ngram: the conversion oft:e1: trigger-arg-path: inactivates >prepc_by >ccomp Bindingt$e1: ents2Label-mention-ngram: Ras byt2e1: ents2Label-mention-ngram: conversion of activet'e1: args2Role-mention-ngram: conversiont,e1: ents2Label-mention-ngram: active Ras-GTPtie1: trigger-arg-path: Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlledtBe1: trigger-arg-path: Negative_regulation >prepc_by >ccomp Bindingtge2: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_productt.e2: args2Role-mention-ngram: THEME to inactivet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_producttre1: trigger-arg-path: inactivates:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] Bindingt/e1: args2Role-mention-ngram: inactivates Ras bytVe1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by >ccomp controlled:Bindingt(e1: ents2Label-mention-ngram: Ras-GTP totGe1: trigger-arg-path: inactivates:Negative_regulation >nsubj controllert1e1: ents2Label-mention-ngram: Ras by acceleratingtqe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themet?e1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_productt7e1: args2Role-mention-ngram: CONTROLLER inactivates RastHe1: trigger-arg-path: inactivates >nsubj controller:Gene_or_gene_productt}e1: trigger-arg-path: inactivates:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlled:Bindingt(e2: args2Role-mention-ngram: to inactivetue2: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_producttie2: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_producttue1: trigger-arg-path: inactivates:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlledt'e1: args2Role-mention-ngram: Ras-GTP totYe1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: the conversiontYe1: trigger-arg-path: inactivates:Negative_regulation >prepc_by >ccomp controlled:Bindingt1e1: args2Role-mention-ngram: conversion of activet%e2: args2Role-mention-ngram: inactivet-e2: ents2Label-mention-ngram: to inactive GDPt?shortest-path: prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp']t0e1: ents2Label-mention-ngram: inactivates Ras byt*e1: args2Role-mention-ngram: conversion oft8e1: args2Role-mention-ngram: accelerating the conversiont3e1: args2Role-mention-ngram: CONTROLLER inactivatest.e1: args2Role-mention-ngram: of active Ras-GTPt0e1: args2Role-mention-ngram: Ras-GTP to inactivet_e1: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] controllert=e1: trigger-arg-path: inactivates >prepc_by >ccomp controlledt#e1: args2Role-mention-ngram: Ras byt,e2: args2Role-mention-ngram: to inactive GDPt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inactivatestEe1: trigger-arg-path: inactivates >prepc_by >ccomp controlled:Bindingtfe1: trigger-arg-path: Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] Bindingt.e1: args2Role-mention-ngram: active Ras-GTP totQe1: trigger-arg-path: inactivates:Negative_regulation >prepc_by >ccomp controlledt0e1: args2Role-mention-ngram: Ras by acceleratingtbe1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by >ccomp controlledtie1: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by >ccomp Bindingt'e2: ents2Label-mention-ngram: GDP boundt&e2: ents2Label-mention-ngram: inactivet&e2: args2Role-mention-ngram: GDP boundtUe1: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt,e1: args2Role-mention-ngram: inactivates Rast>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to inactivet*e2: ents2Label-mention-ngram: inactive GDPt$e1: args2Role-mention-ngram: Ras-GTPtie2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themete1: trigger: inactivatest%e1: ents2Label-mention-ngram: Ras-GTPt/e1: ents2Label-mention-ngram: the conversion oftNe1: trigger-arg-path: inactivates:Negative_regulation >prepc_by >ccomp BindingtXe2: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themetKe1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by >ccomp BindingtNe1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by >ccomp controlledtqe1: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttme2: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_producttqe1: trigger-arg-path: Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlled:Bindingt+e1: args2Role-mention-ngram: active Ras-GTPtze1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_producttte1: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] controllert?e1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlledt]trigger-to-trigger-path: e1:inactivates:Negative_regulation >prepc_by >ccomp e2:bound:Bindingt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=inactivate >prepc_by [lemma='accelerate'] >ccomp [lemma='bind'] controlledt)e1: ents2Label-mention-ngram: inactivatestbe1: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj Gene_or_gene_producttJe1: trigger-arg-path: bound >prep_to [lemma='Raptor'] Gene_or_gene_productt4e2: trigger-arg-path: bound:Binding >nsubjpass themetPe2: trigger-arg-path: bound >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttPe1: trigger-arg-path: bound >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] Gene_or_gene_producttPe1: trigger-arg-path: bound >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttRe1: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] Gene_or_gene_productt;e2: trigger-arg-path: bound >prep_to [lemma='Raptor'] themetAe2: trigger-arg-path: bound >nsubjpass theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME is boundt,e2: trigger-arg-path: bound >nsubjpass themetie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: is bound tot(e2: args2Role-mention-ngram: is bound totLe2: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] Gene_or_gene_producttCe2: trigger-arg-path: bound:Binding >nsubjpass Gene_or_gene_producttXe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttXe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] themetCe1: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] themet;e1: trigger-arg-path: bound >prep_to [lemma='Raptor'] themet[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] Gene_or_gene_productt;e2: trigger-arg-path: bound >nsubjpass [lemma='mtor'] themetXe2: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttXe1: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] themet=e2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass themet[e2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] Gene_or_gene_producttJe2: trigger-arg-path: bound >nsubjpass [lemma='mtor'] Gene_or_gene_producttRe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] Gene_or_gene_productt(e1: args2Role-mention-ngram: is bound tot=e1: trigger-arg-path: Binding >prep_to [lemma='Raptor'] themetLe1: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] themet;e1: trigger-arg-path: bound >nsubjpass [lemma='mtor'] themet>shortest-path: auxpass [lemma='be']tTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] themetae1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttCe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] themet%e2: args2Role-mention-ngram: is boundt-e2: ents2Label-mention-ngram: SHARED is boundtRe1: trigger-arg-path: Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_to [lemma='Raptor'] themetae2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] themet%e2: args2Role-mention-ngram: THEME ist;e2: trigger-arg-path: bound >nsubjpass Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_to [lemma='Raptor'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] themetCe2: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] themetRe1: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttJe1: trigger-arg-path: bound >nsubjpass [lemma='mtor'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] themetRe2: trigger-arg-path: bound:Binding >prep_to [lemma='Raptor'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='mtor'] themet[e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] Gene_or_gene_producttRe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_to [lemma='Raptor'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: is boundt+e2: args2Role-mention-ngram: THEME is boundt[e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Raptor'] Gene_or_gene_producttIe2: trigger-arg-path: bound:Binding >nsubjpass theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >nsubjpass [lemma='mtor'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Raptor'] theme:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass themetTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='mtor'] theme:Gene_or_gene_producttJe2: trigger-arg-path: bound >prep_to [lemma='Raptor'] Gene_or_gene_producttCe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='mtor'] themetPe2: trigger-arg-path: bound >prep_to [lemma='Raptor'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED is boundt)e2: ents2Label-mention-ngram: is bound totLe2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass Gene_or_gene_productt2e2: ents2Label-mention-ngram: promotes cancer cellt6e1: ents2Label-mention-ngram: and antiapoptotic factortMe2: trigger-arg-path: induces:Positive_regulation >dobj controller:BioProcesst+e2: ents2Label-mention-ngram: pro-oncogenict+e1: ents2Label-mention-ngram: migration andt'e1: ents2Label-mention-ngram: , inducest/e2: ents2Label-mention-ngram: 3-kinase enhancertSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controllert%e1: ents2Label-mention-ngram: a novelt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='cdk5'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: Isoform A oft+e1: ents2Label-mention-ngram: antiapoptotict.e1: ents2Label-mention-ngram: growth , inducest)e1: ents2Label-mention-ngram: ( Isoform At!e1: ents2Label-mention-ngram: AKTt0e2: args2Role-mention-ngram: 3-kinase enhancer )t1e2: ents2Label-mention-ngram: novel pro-oncogenict9e1: ents2Label-mention-ngram: glioblastoma cell migrationtQe2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='cell'] controllertye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='cdk5'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: and antiapoptotict?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj BioProcesst1e2: args2Role-mention-ngram: antiapoptotic factort#e2: args2Role-mention-ngram: cancert.e2: trigger-arg-path: induces >dobj BioProcesst6e2: args2Role-mention-ngram: antiapoptotic factor thattJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='cdk5'] controllert)e2: args2Role-mention-ngram: enhancer ) ,the1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='cdk5'] controller:Gene_or_gene_productt=e2: trigger-arg-path: induces >dobj [lemma='cell'] controllert>e2: ents2Label-mention-ngram: of phosphatidylinositol 3-kinaset!e2: ents2Label-mention-ngram: AKTtbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='cell'] controllertJe2: trigger-arg-path: lemmatizedTrigger=induce >dobj controller:BioProcesst^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj controller:BioProcesst%e2: ents2Label-mention-ngram: AKT andt0e2: args2Role-mention-ngram: novel pro-oncogenict5e2: ents2Label-mention-ngram: novel pro-oncogenic andt.e2: ents2Label-mention-ngram: SHARED ( Isoformt/e1: ents2Label-mention-ngram: pro-oncogenic andt)e2: args2Role-mention-ngram: glioblastomat)e2: ents2Label-mention-ngram: of SHARED (t"e1: ents2Label-mention-ngram: A oft2e1: ents2Label-mention-ngram: phosphatidylinositoltEe2: trigger-arg-path: Positive_regulation >dobj controller:BioProcesst0e2: ents2Label-mention-ngram: cancer cell growtht%e2: args2Role-mention-ngram: 3-kinaset)e2: ents2Label-mention-ngram: cancer cellt,e1: ents2Label-mention-ngram: and BIOPROCESSt0e1: ents2Label-mention-ngram: cell migration andt.e2: args2Role-mention-ngram: and antiapoptotictSe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='cdk5'] controllert,e1: ents2Label-mention-ngram: cell migrationt7e2: ents2Label-mention-ngram: antiapoptotic factor thatt+e1: ents2Label-mention-ngram: cell growth ,t/e2: args2Role-mention-ngram: cancer cell growtht2e1: ents2Label-mention-ngram: induces glioblastomatQe2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='cell'] BioProcesst%e1: ents2Label-mention-ngram: AKT andtSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj BioProcesst$e2: args2Role-mention-ngram: a novelt.e2: ents2Label-mention-ngram: AKT and promotest6e1: ents2Label-mention-ngram: migration and BIOPROCESSt)e2: args2Role-mention-ngram: Isoform A oft/e1: ents2Label-mention-ngram: activates AKT andt2e2: args2Role-mention-ngram: a novel pro-oncogenict#e1: ents2Label-mention-ngram: ) , atYe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='cell'] controller:BioProcesst6e2: ents2Label-mention-ngram: and antiapoptotic factort7e2: ents2Label-mention-ngram: A of phosphatidylinositolt+e1: ents2Label-mention-ngram: pro-oncogenictne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='cdk5'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: and promotes cancertPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='cdk5'] controllert.e2: args2Role-mention-ngram: pro-oncogenic andt'e2: ents2Label-mention-ngram: ( Isoformte2: ents2Label-mention-ngram: At2e2: ents2Label-mention-ngram: antiapoptotic factortHe2: trigger-arg-path: induces >dobj [lemma='cell'] controller:BioProcesst]e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='cdk5'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: factor that activatest=e2: trigger-arg-path: induces >dobj [lemma='cell'] BioProcesst5e2: ents2Label-mention-ngram: of phosphatidylinositolte2: args2Role-mention-ngram: Atdobj [lemma='cell'] BioProcesst*e2: args2Role-mention-ngram: activates AKTt?trigger-to-trigger-path: e1:mediated:Positive_regulation nsubj [lemma='cdk5'] controllert)e2: ents2Label-mention-ngram: factor thattZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='cdk5'] Gene_or_gene_productte1: ents2Label-mention-ngram: At"e2: ents2Label-mention-ngram: A oft?e1: trigger-arg-path: mediated >nsubj [lemma='cdk5'] controllert&e1: ents2Label-mention-ngram: 3-kinasetIe2: trigger-arg-path: Positive_regulation >dobj [lemma='cell'] controllert7e1: ents2Label-mention-ngram: antiapoptotic factor thatt'e1: ents2Label-mention-ngram: migrationt%e2: args2Role-mention-ngram: enhancert)e1: ents2Label-mention-ngram: cancer cellt0e2: args2Role-mention-ngram: and promotes cancert1e1: ents2Label-mention-ngram: 3-kinase enhancer )tDe1: ents2Label-mention-ngram: phosphatidylinositol 3-kinase enhancert(e2: args2Role-mention-ngram: cancer cellt'e2: ents2Label-mention-ngram: Isoform At&e2: args2Role-mention-ngram: Isoform At7e1: ents2Label-mention-ngram: A of phosphatidylinositolt%e2: ents2Label-mention-ngram: Isoformt:e2: trigger-arg-path: Positive_regulation >dobj controllertBe2: trigger-arg-path: induces:Positive_regulation >dobj controllert3e2: args2Role-mention-ngram: , induces glioblastomat-e2: ents2Label-mention-ngram: promotes cancert&e2: args2Role-mention-ngram: ( Isoformt e2: args2Role-mention-ngram: AKTtee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='cdk5'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: factor that activatest/e2: ents2Label-mention-ngram: pro-oncogenic andt2e1: ents2Label-mention-ngram: promotes cancer cellt1e2: args2Role-mention-ngram: CONTROLLED ( Isoformt&e2: args2Role-mention-ngram: , a novelt4e1: ents2Label-mention-ngram: , induces glioblastomat(e2: ents2Label-mention-ngram: enhancer )t*e2: args2Role-mention-ngram: antiapoptotict"e2: args2Role-mention-ngram: novelt*e2: ents2Label-mention-ngram: and promotest.e2: ents2Label-mention-ngram: growth , inducest/e2: ents2Label-mention-ngram: and antiapoptotict1e1: ents2Label-mention-ngram: novel pro-oncogenict%e1: ents2Label-mention-ngram: Isoformt'e2: args2Role-mention-ngram: enhancer )tIe1: trigger-arg-path: mediated >nsubj [lemma='cdk5'] Gene_or_gene_producttetrigger-to-trigger-path: e1:mediated:Positive_regulation dobj [lemma='cell'] BioProcesstCe2: args2Role-mention-ngram: phosphatidylinositol 3-kinase enhancertme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='cell'] controller:BioProcesst.e1: ents2Label-mention-ngram: AKT and promotestDe2: ents2Label-mention-ngram: phosphatidylinositol 3-kinase enhancert)e2: ents2Label-mention-ngram: cell growthtBe2: trigger-arg-path: induces:Positive_regulation >dobj BioProcesst/e2: args2Role-mention-ngram: that activates AKTt%e2: args2Role-mention-ngram: growth ,t4e2: args2Role-mention-ngram: novel pro-oncogenic andt1e2: ents2Label-mention-ngram: 3-kinase enhancer )t\e2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='cell'] controller:BioProcesst:e2: args2Role-mention-ngram: phosphatidylinositol 3-kinaset;e2: ents2Label-mention-ngram: phosphatidylinositol 3-kinaset7e1: ents2Label-mention-ngram: induces glioblastoma cellt+e2: ents2Label-mention-ngram: antiapoptotict:e2: trigger-arg-path: Positive_regulation >dobj BioProcesst1e2: args2Role-mention-ngram: induces glioblastomat'e2: ents2Label-mention-ngram: , inducest/e1: ents2Label-mention-ngram: 3-kinase enhancertNe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='cell'] controllert/e2: ents2Label-mention-ngram: activates AKT andt(e1: ents2Label-mention-ngram: enhancer )t4e2: args2Role-mention-ngram: glioblastoma CONTROLLERt$e1: ents2Label-mention-ngram: cancertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='cdk5'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: ( Isoform At(e2: args2Role-mention-ngram: cell growtht*e2: args2Role-mention-ngram: cell growth ,t*e1: ents2Label-mention-ngram: enhancer ) ,t'e1: ents2Label-mention-ngram: Isoform At/e1: ents2Label-mention-ngram: glioblastoma cellt5e1: ents2Label-mention-ngram: novel pro-oncogenic andt*e1: ents2Label-mention-ngram: Isoform A oft*e2: ents2Label-mention-ngram: enhancer ) ,t)e2: args2Role-mention-ngram: and promotest9e2: trigger-arg-path: induces >dobj controller:BioProcesst$e2: args2Role-mention-ngram: Isoformt5e2: ents2Label-mention-ngram: glioblastoma BIOPROCESSt$e2: ents2Label-mention-ngram: cancertdobj controllert(e2: args2Role-mention-ngram: ( Isoform At.e2: args2Role-mention-ngram: 3-kinase enhancert*e2: args2Role-mention-ngram: pro-oncogenict3e2: ents2Label-mention-ngram: a novel pro-oncogenict.e2: trigger-arg-path: induces >dobj controllert-e1: ents2Label-mention-ngram: promotes cancert=e2: ents2Label-mention-ngram: pro-oncogenic and antiapoptotict#e2: args2Role-mention-ngram: factortTe2: trigger-arg-path: Positive_regulation >dobj [lemma='cell'] controller:BioProcesst4e2: args2Role-mention-ngram: of phosphatidylinositolt+e1: ents2Label-mention-ngram: activates AKTt>e1: ents2Label-mention-ngram: of phosphatidylinositol 3-kinaset#e2: args2Role-mention-ngram: growtht2e2: ents2Label-mention-ngram: phosphatidylinositolt&e2: ents2Label-mention-ngram: growth ,t1e1: ents2Label-mention-ngram: and promotes cancert&e2: args2Role-mention-ngram: , inducest&e1: ents2Label-mention-ngram: growth ,t%e2: ents2Label-mention-ngram: a novelt*e1: ents2Label-mention-ngram: glioblastomat;e1: ents2Label-mention-ngram: phosphatidylinositol 3-kinaset*e2: ents2Label-mention-ngram: glioblastomat5e1: ents2Label-mention-ngram: of phosphatidylinositolt0e1: ents2Label-mention-ngram: cancer cell growthtNe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='cell'] BioProcesst2e2: args2Role-mention-ngram: factor that activatest=e2: args2Role-mention-ngram: of phosphatidylinositol 3-kinasetTe1: trigger-arg-path: mediated >nsubj [lemma='cdk5'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: , induces glioblastomat2e2: ents2Label-mention-ngram: induces glioblastomat1e2: args2Role-mention-ngram: promotes cancer cellt+e2: args2Role-mention-ngram: that activatest!e2: args2Role-mention-ngram: A oft)e1: ents2Label-mention-ngram: cell growtht=e2: ents2Label-mention-ngram: induces glioblastoma BIOPROCESSt6e2: args2Role-mention-ngram: A of phosphatidylinositolt-e2: args2Role-mention-ngram: growth , inducest+e2: ents2Label-mention-ngram: cell growth ,t,e2: ents2Label-mention-ngram: that activatest1e2: ents2Label-mention-ngram: and inhibits SHAREDtBe2: trigger-arg-path: inhibits dobj [lemma='binding'] controlledtHe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:BindingtRe2: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='binding'] Bindingt[e2: trigger-arg-path: lemmatizedTrigger=inhibit conj_and e2:inhibits:Negative_regulationt=e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Bindingtce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='binding'] Bindingt0e2: trigger-arg-path: inhibits e2: trigger-arg-path: inhibits >dobj [lemma='binding'] Bindingt7e2: trigger-arg-path: inhibits >dobj controlled:Bindingt^e2: trigger-arg-path: inhibits:Negative_regulation dobj [lemma='binding'] controlled:Bindingt>e2: trigger-arg-path: Negative_regulation dobj [lemma='binding'] controlled:BindingtIe2: trigger-arg-path: Negative_regulation >dobj [lemma='binding'] BindingtOe2: trigger-arg-path: inhibits:Negative_regulation dobj Bindingt4e2: args2Role-mention-ngram: and inhibits CONTROLLEDtOe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='binding'] BindingtBe2: ents2Label-mention-ngram: inhibits SHARED GENE_OR_GENE_PRODUCTt@e2: trigger-arg-path: inhibits:Negative_regulation >dobj Bindingt1e2: ents2Label-mention-ngram: SHARED and inhibitstetrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='inhibit'] e2:inhibits:Negative_regulationt\e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlled:BindingtUe2: trigger-arg-path: Negative_regulation dobj controlled:Bindingt,e2: trigger-arg-path: inhibits >dobj Bindingt+e2: ents2Label-mention-ngram: to SHARED andtPe2: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='binding'] controlledtoe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation dobj [lemma='binding'] controlledt;e2: trigger-arg-path: Negative_regulation dobj [lemma='binding'] controlledtKe2: trigger-arg-path: inhibits:Negative_regulation >dobj controlled:BindingtCe2: trigger-arg-path: inhibits:Negative_regulation >dobj controlledtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='binding'] controlled:BindingtTe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlledtVe2: trigger-arg-path: inhibits:Negative_regulation dobj [lemma='binding'] controlled:BindingtUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation dobj [lemma='binding'] controlled:Bindingt7e2: trigger-arg-path: Negative_regulation >dobj BindingtSe2: trigger-arg-path: inhibits:Negative_regulation dobj [lemma='binding'] controlledtEe1: trigger-arg-path: Binding >nn [lemma='e2f1'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >nn [lemma='p73'] theme:Gene_or_gene_producttQe2: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] controllertKe1: trigger-arg-path: Binding >nn [lemma='e2f1'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p73'] Gene_or_gene_producttJe1: trigger-arg-path: complex >nn [lemma='p73'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: Chk1 andtHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='e2f1'] themet"e2: ents2Label-mention-ngram: Chk1t6e1: trigger-arg-path: complex >nn [lemma='e2f1'] themet%e2: ents2Label-mention-ngram: by Chk1t;e2: args2Role-mention-ngram: CONTROLLER promotes CONTROLLEDtLe1: trigger-arg-path: complex:Binding >nn [lemma='p73'] Gene_or_gene_productt0e2: trigger-arg-path: promotes >nsubj controllert)interceding-token ngrams: inhibitory MDM2t|trigger-to-trigger-path: e1:complex:Binding advcl [lemma='promote'] e2:promotes:Positive_regulationtee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='e2f1'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='e2f1'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] controllertZe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj Simple_chemicalt;e2: ents2Label-mention-ngram: Chk1 and GENE_OR_GENE_PRODUCTtOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p73'] themet=e1: trigger-arg-path: complex:Binding >nn [lemma='p73'] themetTe2: trigger-arg-path: promotes:Positive_regulation >nsubj controller:Simple_chemicalt{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltSe1: trigger-arg-path: complex:Binding >nn [lemma='e2f1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controller:Simple_chemicalt@e2: trigger-arg-path: promotes >nsubj controller:Simple_chemicaltDe2: trigger-arg-path: promotes:Positive_regulation >nsubj controllertFe2: ents2Label-mention-ngram: SIMPLE_CHEMICAL promotes phosphorylationt&shortest-path: advcl >nsubjt)interceding-token ngrams: binding , whiletRe1: trigger-arg-path: complex:Binding >nn [lemma='p73'] theme:Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='e2f1'] themetGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p73'] themetDe1: trigger-arg-path: complex >nn [lemma='p73'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] controllertFe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj Simple_chemicalt\e2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] Simple_chemicaltFe2: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] controllertXtrigger-to-trigger-path: e1:complex:Binding advcl e2:promotes:Positive_regulationtpe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicaltIe2: trigger-arg-path: promotes:Positive_regulation >nsubj Simple_chemicaltQe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj controller:Simple_chemicalt#interceding-token ngrams: binding ,t5e1: trigger-arg-path: Binding >nn [lemma='p73'] themet5e1: trigger-arg-path: complex >nn [lemma='p73'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p73'] Gene_or_gene_producttKe2: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] Simple_chemicaltDe1: trigger-arg-path: Binding >nn [lemma='p73'] Gene_or_gene_productt5e2: trigger-arg-path: promotes >nsubj Simple_chemicalt6e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL promotest_e2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicaltrshortest-path: advcl [lemma='promote'] >nsubj [lemma='doxorubicin']t)e2: ents2Label-mention-ngram: by Chk1 andt6e2: ents2Label-mention-ngram: promotes phosphorylationt1interceding-token ngrams: inhibitory MDM2 bindingtde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p73'] theme:Gene_or_gene_producttEe1: trigger-arg-path: complex >nn [lemma='e2f1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED by Chk1t>e1: trigger-arg-path: complex:Binding >nn [lemma='e2f1'] themet\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p73'] theme:Gene_or_gene_productt)interceding-token ngrams: from inhibitoryt9e2: ents2Label-mention-ngram: promotes phosphorylation oftAe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj controllertje2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltinterceding-token ngrams: MDM2tWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='e2f1'] Gene_or_gene_productt(interceding-token ngrams: MDM2 binding ,tKe1: trigger-arg-path: complex >nn [lemma='e2f1'] theme:Gene_or_gene_productt&interceding-token ngrams: MDM2 bindingt6e1: trigger-arg-path: Binding >nn [lemma='e2f1'] themet_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='e2f1'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controllert.interceding-token ngrams: from inhibitory MDM2tVe2: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltBinterceding-tokens-full-span: from inhibitory MDM2 binding , whiletZe2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] controllertge2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] controller:Simple_chemicalt0e2: args2Role-mention-ngram: CONTROLLER promotestMe1: trigger-arg-path: complex:Binding >nn [lemma='e2f1'] Gene_or_gene_producttVe2: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicaltGe2: trigger-arg-path: inhibit >dobj [lemma='mtor'] Gene_or_gene_productt&shortest-path: nsubj >nn Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: the intracellulart)e2: ents2Label-mention-ngram: SHARED formte1: trigger: form a complextPe2: trigger-arg-path: lemmatizedTrigger=inhibit prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] Gene_or_gene_producttCe1: trigger-arg-path: Binding nsubj >nn Simple_chemicalt'e1: args2Role-mention-ngram: THEME formt+e2: ents2Label-mention-ngram: intracellulart9e1: trigger-arg-path: Binding nsubj >nn themet"e1: ents2Label-mention-ngram: formtIe2: trigger-arg-path: inhibit conj_and [lemma='inhibit'] e2:inhibit:Negative_activationt.e1: ents2Label-mention-ngram: complex with thet[e2: trigger-arg-path: lemmatizedTrigger=inhibit prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] Gene_or_gene_producttLe1: trigger-arg-path: form a complex:Binding prep_with >nn themetJe2: trigger-arg-path: Negative_activation prep_with >nn themetRe1: trigger-arg-path: Binding prep_with >nn theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj [lemma='mtor'] controlled:Gene_or_gene_productt=e1: trigger-arg-path: Binding prep_with >nn themet?e1: trigger-arg-path: form a complex nsubj [lemma='inhibitor'] >nn [lemma='mtor'] Simple_chemicalt?e1: trigger-arg-path: form a complex nsubj [lemma='inhibitor'] >nn [lemma='mtor'] theme:Simple_chemicalt@e1: trigger-arg-path: form a complex nsubj >nn themet?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] themetJe1: trigger-arg-path: form a complex nsubj >nn Simple_chemicaltYe1: trigger-arg-path: form a complex prep_with >nn theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj >nn themet/e2: ents2Label-mention-ngram: the intracellulartRe1: trigger-arg-path: form a complex:Binding nsubj >nn Simple_chemicalt6e2: ents2Label-mention-ngram: intracellular SHARED andt2e2: ents2Label-mention-ngram: intracellular SHAREDtUe2: trigger-arg-path: Negative_activation prep_with >nn themetPe1: trigger-arg-path: form a complex nsubj >nn theme:Simple_chemicaltXe1: trigger-arg-path: form a complex:Binding nsubj >nn theme:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] Gene_or_gene_productt0e1: args2Role-mention-ngram: intracellular THEMEt-e1: args2Role-mention-ngram: complex with thet?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='inhibitor'] >nn [lemma='mtor'] theme:Simple_chemicalt3e1: args2Role-mention-ngram: with the intracellulart?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] themetWe2: trigger-arg-path: inhibit:Negative_activation >dobj controlled:Gene_or_gene_producttUe2: trigger-arg-path: inhibit:Negative_activation nsubj [lemma='inhibitor'] >nn [lemma='mtor'] theme:Simple_chemicalt6e2: ents2Label-mention-ngram: the intracellular SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: form a complextftrigger-to-trigger-path: e1:form a complex:Binding conj_and e2:inhibit:Negative_activationt4e1: ents2Label-mention-ngram: with the intracellulart}e1: trigger-arg-path: Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] themet)e1: args2Role-mention-ngram: THEME form at.e2: trigger-arg-path: inhibit >dobj controlledt?e1: trigger-arg-path: Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] theme:Simple_chemicalt:e2: ents2Label-mention-ngram: inhibit GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] theme:Gene_or_gene_productt?e1: trigger-arg-path: form a complex prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: form at?e1: trigger-arg-path: Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] themet4e1: args2Role-mention-ngram: the intracellular THEMEtae1: trigger-arg-path: form a complex:Binding prep_with >nn theme:Gene_or_gene_productt[e2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='mtor'] Gene_or_gene_producttDe1: trigger-arg-path: form a complex prep_with >nn themet.e1: args2Role-mention-ngram: the intracellulart$e2: ents2Label-mention-ngram: form atee1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with >nn Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with >nn Gene_or_gene_productt?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] Simple_chemicalt]e2: trigger-arg-path: inhibit:Negative_activation prep_with >nn Gene_or_gene_productt?e1: trigger-arg-path: form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] theme:Simple_chemicaltSe1: trigger-arg-path: form a complex prep_with >nn Gene_or_gene_producttHe1: trigger-arg-path: form a complex:Binding nsubj >nn themetQe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='mtor'] controlledtAe2: trigger-arg-path: inhibit prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='inhibitor'] >nn [lemma='mtor'] Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=inhibit e2: ents2Label-mention-ngram: and inhibit GENE_OR_GENE_PRODUCTtZe1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj >nn themetCe2: trigger-arg-path: inhibit:Negative_activation dobj [lemma='mtor'] controlled:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with >nn theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] themetBe2: trigger-arg-path: inhibit:Negative_activation >dobj controlledt=e2: trigger-arg-path: inhibit >dobj [lemma='mtor'] controlledtXe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj >nn theme:Simple_chemicalt?e1: trigger-arg-path: Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] Simple_chemicalt`e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj [lemma='inhibitor'] >nn [lemma='mtor'] themetse1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with >nn theme:Gene_or_gene_productt?e1: trigger-arg-path: form a complex prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] Gene_or_gene_productt:e2: trigger-arg-path: inhibit prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] themet8e2: trigger-arg-path: inhibit >dobj Gene_or_gene_producttIe1: trigger-arg-path: Binding nsubj >nn theme:Simple_chemicalt?e1: trigger-arg-path: form a complex:Binding prep_with [lemma='fkbp12'] >nn [lemma='immunophilin'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='inhibitor'] >nn [lemma='mtor'] Simple_chemicaltCe2: trigger-arg-path: inhibit >dobj controlled:Gene_or_gene_productt*e1: args2Role-mention-ngram: intracellulart,e1: ents2Label-mention-ngram: form a complextMe2: trigger-arg-path: Negative_activation nsubj [lemma='inhibitor'] >nn [lemma='mtor'] themet4e2: ents2Label-mention-ngram: with the intracellulart/e2: trigger-arg-path: inhibit nsubj >nn Simple_chemicalt>e2: trigger-arg-path: inhibit nsubj [lemma='inhibitor'] >nn [lemma='mtor'] themetLe2: trigger-arg-path: inhibit:Negative_activation >dobj Gene_or_gene_productt.e2: ents2Label-mention-ngram: complex with thet,e2: ents2Label-mention-ngram: form a complextje1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj >nn theme:Simple_chemicaltLe1: trigger-arg-path: Binding prep_with >nn Gene_or_gene_producttFe2: trigger-arg-path: inhibit:Negative_activation nsubj [lemma='tln-4601'] controller:Gene_or_gene_productt?e2: trigger-arg-path: inhibiting nn [lemma='raf-1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='raf-1'] Gene_or_gene_productt>e2: trigger-arg-path: Negative_regulation nn controlledtfe2: trigger-arg-path: Negative_regulation nn [lemma='mek'] controlledtBe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj controllertEe2: trigger-arg-path: inhibiting nn controlled:Phosphorylationtgtrigger-to-trigger-path: e1:decreases:Negative_regulation >dobj >amod e2:inhibiting:Negative_regulationt'e2: args2Role-mention-ngram: inhibitingt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='raf-1'] controllert.e1: ents2Label-mention-ngram: , inhibiting MEKtDe1: trigger-arg-path: decreases >nsubj [lemma='tln-4601'] controllertAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT protein levelst$e2: ents2Label-mention-ngram: levelstie1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='tln-4601'] controllertEe1: ents2Label-mention-ngram: decreases cellular GENE_OR_GENE_PRODUCTtwe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: decreasestbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn controllertXe1: trigger-arg-path: decreases:Negative_regulation >nsubj [lemma='tln-4601'] controllert0e1: args2Role-mention-ngram: cellular CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='mek'] Phosphorylationt!e1: ents2Label-mention-ngram: MEKtve2: trigger-arg-path: Negative_regulation nn [lemma='mek'] controlled:Phosphorylationt?e2: trigger-arg-path: inhibiting nn controllert%e1: args2Role-mention-ngram: cellulart(e2: ents2Label-mention-ngram: inhibitingt]e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn Phosphorylationt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT proteint?e2: trigger-arg-path: Negative_regulation nn [lemma='raf-1'] Gene_or_gene_producttIe2: trigger-arg-path: inhibiting nn Gene_or_gene_productt4e2: args2Role-mention-ngram: , inhibiting CONTROLLEDt#e2: args2Role-mention-ngram: levelst%e2: args2Role-mention-ngram: levels ,tXe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn controlledte2: trigger: inhibitingt?e2: trigger-arg-path: Negative_regulation nn [lemma='raf-1'] controllert]e2: trigger-arg-path: inhibiting:Negative_regulation nn Gene_or_gene_productt&e1: ents2Label-mention-ngram: cellulartEe1: trigger-arg-path: decreases:Negative_regulation >nsubj controllert;e1: ents2Label-mention-ngram: cellular GENE_OR_GENE_PRODUCTt?e2: ents2Label-mention-ngram: , inhibiting GENE_OR_GENE_PRODUCTt`e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER decreasestqe2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='mek'] PhosphorylationtZe1: trigger-arg-path: decreases:Negative_regulation >nsubj controller:Gene_or_gene_producttIe2: trigger-arg-path: inhibiting:Negative_regulation nn controlledt:e1: args2Role-mention-ngram: CONTROLLER decreases cellulart?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='mek'] controlled:Phosphorylationt]e2: trigger-arg-path: Negative_regulation nn controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn Gene_or_gene_productt?e2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='raf-1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='raf-1'] controllertse1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='tln-4601'] Gene_or_gene_producttYe2: trigger-arg-path: inhibiting:Negative_regulation nn controlled:Phosphorylationt0e2: args2Role-mention-ngram: levels , inhibitingt?e2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='mek'] controlled:Phosphorylationt1e1: ents2Label-mention-ngram: MEK phosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=inhibit nn Gene_or_gene_productt*e1: ents2Label-mention-ngram: , inhibitingt6e2: args2Role-mention-ngram: CONTROLLER protein levelst:e2: trigger-arg-path: inhibiting nn Phosphorylationtke2: trigger-arg-path: Negative_regulation nn [lemma='mek'] PhosphorylationtFe1: trigger-arg-path: decreases >nsubj controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=inhibit nn controller:Gene_or_gene_producttNe2: trigger-arg-path: inhibiting:Negative_regulation nn Phosphorylationtje1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='tln-4601'] controller:Gene_or_gene_producttbe2: trigger-arg-path: inhibiting nn [lemma='mek'] PhosphorylationtIe2: trigger-arg-path: lemmatizedTrigger=inhibit nn Phosphorylationt,e1: ents2Label-mention-ngram: protein levelst*e2: ents2Label-mention-ngram: , inhibitingt&e2: ents2Label-mention-ngram: levels ,t(e1: ents2Label-mention-ngram: inhibitingt?e2: trigger-arg-path: Negative_regulation nn [lemma='raf-1'] controller:Gene_or_gene_productt5e2: trigger-arg-path: inhibiting nn controlledtSe2: trigger-arg-path: inhibiting:Negative_regulation nn controllertYe1: trigger-arg-path: decreases >nsubj [lemma='tln-4601'] controller:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=inhibit nn controllertNe1: trigger-arg-path: Negative_regulation >nsubj [lemma='tln-4601'] controllertLe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj Gene_or_gene_producttnsubj [lemma='tln-4601'] Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=inhibit nn controlledtqe2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='mek'] controlledt&e1: ents2Label-mention-ngram: levels ,te1: trigger: decreasestRshortest-path: dobj [lemma='level'] >nn [lemma='raf-1']tRe2: trigger-arg-path: Negative_regulation nn Gene_or_gene_producttve2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='mek'] PhosphorylationtVe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj controllert?trigger-to-trigger-path: e1:decreases:Negative_regulation >dobj [lemma='phosphorylation'] >amod [lemma='inhibit'] e2:inhibiting:Negative_regulationt)e2: args2Role-mention-ngram: , inhibitingt2e2: args2Role-mention-ngram: inhibiting CONTROLLEDtye2: trigger-arg-path: inhibiting nn [lemma='raf-1'] controllertHe2: trigger-arg-path: Negative_regulation nn controllertme2: trigger-arg-path: inhibiting nn [lemma='mek'] controlled:Phosphorylationt/e1: args2Role-mention-ngram: decreases cellularthe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn controlled:Phosphorylationt,e2: ents2Label-mention-ngram: protein levelst.e2: ents2Label-mention-ngram: protein levels ,t+e2: args2Role-mention-ngram: protein levelstCe2: trigger-arg-path: Negative_regulation nn Phosphorylationt~e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='tln-4601'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: levels , inhibitingtOe1: trigger-arg-path: decreases:Negative_regulation >nsubj Gene_or_gene_producttce1: trigger-arg-path: Negative_regulation >nsubj [lemma='tln-4601'] controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: decreasestUe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='tln-4601'] controllert?e2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='raf-1'] controller:Gene_or_gene_producttnn [lemma='mek'] controlledtEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT decreases cellulart?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='raf-1'] Gene_or_gene_producttCe1: ents2Label-mention-ngram: cellular GENE_OR_GENE_PRODUCT proteint?e2: trigger-arg-path: inhibiting:Negative_regulation nn [lemma='raf-1'] Gene_or_gene_producttNe1: trigger-arg-path: decreases >nsubj [lemma='tln-4601'] Gene_or_gene_productt:e1: args2Role-mention-ngram: decreases cellular CONTROLLEDtle2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='mek'] controlledtke1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj controller:Gene_or_gene_producttNe2: trigger-arg-path: Negative_regulation nn controlled:Phosphorylationt-e2: args2Role-mention-ngram: protein levels ,tTe2: trigger-arg-path: inhibiting nn controller:Gene_or_gene_producttAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT protein levelsthe2: trigger-arg-path: inhibiting:Negative_regulation nn controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: decreases cellulartbe1: trigger-arg-path: decreases:Negative_regulation >nsubj [lemma='tln-4601'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='raf-1'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: protein levels ,t1e2: ents2Label-mention-ngram: levels , inhibitingtTe2: trigger-arg-path: lemmatizedTrigger=inhibit nn controlled:PhosphorylationtXe1: trigger-arg-path: Negative_regulation >nsubj [lemma='tln-4601'] Gene_or_gene_productt;e1: trigger-arg-path: decreases >nsubj Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='mek'] controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nn [lemma='mek'] controlledt?e2: trigger-arg-path: inhibiting nn [lemma='raf-1'] controller:Gene_or_gene_productt1e1: trigger-arg-path: decreases >nsubj controllertBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit nn [lemma='raf-1'] controllertue2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controllertFe1: trigger-arg-path: lemmatizedTrigger=cause >nsubj >appos controllertinterceding-token ngrams: JARt>e2: trigger-arg-path: phosphorylation >prep_of >prep_by Familyt$interceding-token ngrams: in JAR andtqe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controllert,e1: args2Role-mention-ngram: ) causes markedt?trigger-to-trigger-path: e1:causes:Positive_regulation >vmod [lemma='indicate'] >ccomp [lemma='activate'] >nsubj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtde1: trigger-arg-path: causes >nsubj [lemma='a'] >appos [lemma='tsa'] controller:Gene_or_gene_producttinterceding-token ngrams: MCF-7tOe1: trigger-arg-path: causes >nsubj [lemma='a'] >appos [lemma='tsa'] controllert~e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controller:Familyt'interceding-token ngrams: MCF-7 cells ,t5e1: args2Role-mention-ngram: causes marked CONTROLLEDtje1: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='a'] >appos [lemma='tsa'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: marked phosphorylation oft_e2: trigger-arg-path: phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] FamilytPe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by Familyt+e1: ents2Label-mention-ngram: SHARED at Sert\e1: trigger-arg-path: Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controllert?e1: trigger-arg-path: causes >nsubj >appos Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=cause >nsubj >appos Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controller:Familyt.e2: ents2Label-mention-ngram: SHARED by FAMILYt(e1: ents2Label-mention-ngram: at Ser 641t!e1: ents2Label-mention-ngram: Sert'interceding-token ngrams: JAR and MCF-7tMe2: trigger-arg-path: Positive_regulation >prep_of >prep_by controller:Familyt'e2: ents2Label-mention-ngram: by FAMILYt[e1: trigger-arg-path: lemmatizedTrigger=cause >nsubj >appos controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: causes markedt~e1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] Gene_or_gene_productt]e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by controller:Familyt$e1: ents2Label-mention-ngram: at Sert(e1: ents2Label-mention-ngram: Ser 641 bytce1: trigger-arg-path: causes:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controllert5e1: trigger-arg-path: causes >nsubj >appos controllertde1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj >appos Gene_or_gene_producttIe1: trigger-arg-path: causes:Positive_regulation >nsubj >appos controllertte1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controllert#interceding-token ngrams: and MCF-7tue1: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='a'] >appos [lemma='tsa'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: Ser 641t)interceding-token ngrams: and MCF-7 cellstse2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] Familytxe1: trigger-arg-path: causes:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controller:Familytne2: trigger-arg-path: Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controller:Familyt$e1: ents2Label-mention-ngram: markedtJe1: trigger-arg-path: causes >nsubj >appos controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='a'] >appos [lemma='tsa'] controllertFinterceding-tokens-full-span: in JAR and MCF-7 cells , indicating thatt-e1: ents2Label-mention-ngram: ) causes markedt0shortest-path: vmod >ccomp >nsubjt?e1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controller:Gene_or_gene_producttje2: trigger-arg-path: phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controller:Familytoe1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj >appos controller:Gene_or_gene_producttIe2: trigger-arg-path: phosphorylation >prep_of >prep_by controller:Familyt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by controller:Familyt%interceding-token ngrams: MCF-7 cellstqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] controller:Gene_or_gene_productt!interceding-token ngrams: JAR andtce2: trigger-arg-path: Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] Familyt0e1: args2Role-mention-ngram: CONTROLLER ) causest?shortest-path: vmod [lemma='indicate'] >ccomp [lemma='activate'] >nsubj [lemma='phosphorylation']t;e1: ents2Label-mention-ngram: causes marked phosphorylationt!e1: ents2Label-mention-ngram: 641tme1: trigger-arg-path: causes:Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] Gene_or_gene_productt#e1: args2Role-mention-ngram: markedt.e1: args2Role-mention-ngram: marked CONTROLLEDt,interceding-token ngrams: cells , indicatingt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ) causest%e1: args2Role-mention-ngram: ) causest4e1: ents2Label-mention-ngram: marked phosphorylationtce2: trigger-arg-path: phosphorylation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controllertRe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of >prep_by Familyt9e1: ents2Label-mention-ngram: 641 by GENE_OR_GENE_PRODUCTt+e1: ents2Label-mention-ngram: causes markedt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] Familyt&e1: ents2Label-mention-ngram: ) causestZe1: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation >nsubj >appos controllertqtrigger-to-trigger-path: e1:causes:Positive_regulation >vmod >ccomp >nsubj e2:phosphorylation:Positive_regulationtoe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by controller:Familytfe1: trigger-arg-path: Positive_regulation >nsubj [lemma='a'] >appos [lemma='tsa'] Gene_or_gene_productt interceding-token ngrams: in JARtBe2: trigger-arg-path: Positive_regulation >prep_of >prep_by Familytwe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controllertge2: trigger-arg-path: Positive_regulation >prep_of [lemma='sp1'] >prep_by [lemma='3-kinase'] controllertYe1: trigger-arg-path: causes >nsubj [lemma='a'] >appos [lemma='tsa'] Gene_or_gene_producttSe1: trigger-arg-path: causes:Positive_regulation >nsubj >appos Gene_or_gene_productt$e1: ents2Label-mention-ngram: 641 byt^e1: trigger-arg-path: causes:Positive_regulation >nsubj >appos controller:Gene_or_gene_producttIe1: trigger-arg-path: inhibited >nsubj [lemma='bbr'] Gene_or_gene_productt^e2: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_producttOe1: trigger-arg-path: inhibited:Negative_activation >nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='bbr'] controllertje1: trigger-arg-path: inhibited >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] Gene_or_gene_producttnsubj [lemma='bbr'] controller:Gene_or_gene_producttJe2: trigger-arg-path: suppressed >nsubj [lemma='bbr'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of controlled:Generic_entityt9e2: ents2Label-mention-ngram: SHARED inhibited HIF-1alphatLe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj Gene_or_gene_producttIe1: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] controllert>e1: trigger-arg-path: inhibited >dobj >nn Gene_or_gene_productt2e2: ents2Label-mention-ngram: protein accumulationt~e1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] Gene_or_gene_producttZe1: trigger-arg-path: inhibited:Negative_activation >nsubj controller:Gene_or_gene_producttTe1: trigger-arg-path: inhibited >nsubj [lemma='bbr'] controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: HIF-1alphat'e2: args2Role-mention-ngram: , and thentUe2: trigger-arg-path: suppressed >nsubj [lemma='bbr'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] controller:Gene_or_gene_producttnsubj Gene_or_gene_productt+e2: args2Role-mention-ngram: suppressed thet,e2: ents2Label-mention-ngram: suppressed thet.e2: args2Role-mention-ngram: the expression oft4e2: args2Role-mention-ngram: protein accumulation intce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='bbr'] controllert0e2: ents2Label-mention-ngram: the related SHAREDtde2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='bbr'] controllert,e2: ents2Label-mention-ngram: of the relatedt/e2: ents2Label-mention-ngram: expression of thetRe1: trigger-arg-path: inhibited:Negative_activation >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] Gene_or_gene_producttue1: trigger-arg-path: inhibited >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlled:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj controllerte1: trigger-arg-path: Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlled:Gene_or_gene_productt+e2: args2Role-mention-ngram: of the relatedtie2: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='bbr'] controller:Gene_or_gene_productt9e2: args2Role-mention-ngram: inhibited HIF-1alpha proteint?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] controlledt(e2: ents2Label-mention-ngram: , and thent?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlledtSe1: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_productt]e2: trigger-arg-path: suppressed:Negative_activation >dobj >prep_of controlled:Generic_entitytve2: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] Generic_entityt!e2: args2Role-mention-ngram: lungt/e2: ents2Label-mention-ngram: the expression oft,e2: ents2Label-mention-ngram: related SHAREDt,e2: ents2Label-mention-ngram: in lung cancertYe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of controlled:Generic_entitytxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='bbr'] controller:Gene_or_gene_producttHe1: trigger-arg-path: inhibited:Negative_activation >dobj >nn controlledtpe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlledtdobj [lemma='expression'] >prep_of [lemma='gene'] controlled:Generic_entitytZe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='bbr'] Gene_or_gene_producttCe2: trigger-arg-path: Negative_activation >dobj >prep_of controlledt)e2: ents2Label-mention-ngram: the relatedtOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] controllertme2: trigger-arg-path: suppressed >dobj [lemma='expression'] >prep_of [lemma='gene'] controlled:Generic_entityt:e2: trigger-arg-path: suppressed >dobj >prep_of controlledtRe2: trigger-arg-path: suppressed:Negative_activation >dobj >prep_of Generic_entityt/e2: args2Role-mention-ngram: related CONTROLLEDt*e2: ents2Label-mention-ngram: cancer cellstve2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] controlled:Generic_entityt1e2: args2Role-mention-ngram: accumulation in lungtte1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlledt5e2: ents2Label-mention-ngram: protein accumulation int?e1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: lung cancert1e2: ents2Label-mention-ngram: and then suppressedt)e2: ents2Label-mention-ngram: cells , andt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] Generic_entitytNe2: trigger-arg-path: suppressed:Negative_activation >dobj >prep_of controlledt^e1: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of controlledtJe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of controlledt4e1: trigger-arg-path: inhibited >dobj >nn controlledt+e2: args2Role-mention-ngram: in lung cancert%e2: ents2Label-mention-ngram: relatedtnsubj controller:Gene_or_gene_producttte1: trigger-arg-path: Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] Gene_or_gene_productt>e2: trigger-arg-path: suppressed >dobj >prep_of Generic_entityt?e1: trigger-arg-path: inhibited >nsubj [lemma='bbr'] controllert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlled:Gene_or_gene_productt6e2: args2Role-mention-ngram: suppressed the expressiontne2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='expression'] >prep_of [lemma='gene'] controlledt]e1: trigger-arg-path: inhibited:Negative_activation >dobj >nn controlled:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: lung cancer cellstPe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='bbr'] controllertNe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of Generic_entitytge2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] controlledtIe1: trigger-arg-path: inhibited >dobj >nn controlled:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_productt(e2: args2Role-mention-ngram: the relatedthe1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='bbr'] controller:Gene_or_gene_producttGe2: trigger-arg-path: Negative_activation >dobj >prep_of Generic_entityt-e2: ents2Label-mention-ngram: accumulation int1e2: args2Role-mention-ngram: inhibited HIF-1alphatke2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] controlled:Generic_entityt)e2: args2Role-mention-ngram: cancer cellst%e2: ents2Label-mention-ngram: in lungtde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='bbr'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: then suppressedt2e2: ents2Label-mention-ngram: accumulation in lungt+e2: args2Role-mention-ngram: cancer cells ,t1e2: ents2Label-mention-ngram: then suppressed thet(e2: args2Role-mention-ngram: lung cancert2e2: ents2Label-mention-ngram: inhibited HIF-1alphat*e2: args2Role-mention-ngram: expression oft0e2: ents2Label-mention-ngram: HIF-1alpha proteintGe2: trigger-arg-path: suppressed >nsubj controller:Gene_or_gene_producttetrigger-to-trigger-path: e1:inhibited:Negative_activation >conj_and e2:suppressed:Negative_activationt7e2: ents2Label-mention-ngram: suppressed the expressiontbe2: trigger-arg-path: suppressed >dobj [lemma='expression'] >prep_of [lemma='gene'] Generic_entityt`e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj Gene_or_gene_productt$e2: args2Role-mention-ngram: relatedt}e2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='expression'] >prep_of [lemma='gene'] controlled:Generic_entitytIe2: trigger-arg-path: suppressed >dobj >prep_of controlled:Generic_entityt(e2: args2Role-mention-ngram: cells , andt,e2: ents2Label-mention-ngram: cancer cells ,t"e2: ents2Label-mention-ngram: lungt,e2: args2Role-mention-ngram: accumulation int:e2: ents2Label-mention-ngram: inhibited HIF-1alpha proteintIe2: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] controllert%e2: ents2Label-mention-ngram: cells ,t/e2: ents2Label-mention-ngram: lung cancer cellst/e2: args2Role-mention-ngram: HIF-1alpha proteint0e2: args2Role-mention-ngram: and then suppressedtSe2: trigger-arg-path: Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_productt]e1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='bbr'] Gene_or_gene_producttje1: trigger-arg-path: Negative_activation >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlledt+e2: args2Role-mention-ngram: the expressiont$e2: args2Role-mention-ngram: in lungt1e2: args2Role-mention-ngram: protein accumulationt.e2: args2Role-mention-ngram: expression of thetRe2: trigger-arg-path: Negative_activation >dobj >prep_of controlled:Generic_entityt=e2: ents2Label-mention-ngram: HIF-1alpha protein accumulationtxtrigger-to-trigger-path: e1:inhibited:Negative_activation >conj_and [lemma='suppress'] e2:suppressed:Negative_activationt`e1: trigger-arg-path: inhibited >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] controlledt0e2: args2Role-mention-ngram: then suppressed thetbe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of Generic_entityt@e2: trigger-arg-path: suppressed >nsubj [lemma='bbr'] controllert,e2: ents2Label-mention-ngram: the expressiontEe1: trigger-arg-path: inhibited:Negative_activation >nsubj controllertYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: expression oftFe2: trigger-arg-path: suppressed:Negative_activation >nsubj controllertre2: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] controlledtCe1: ents2Label-mention-ngram: SHARED inhibited GENE_OR_GENE_PRODUCTtSe1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='bbr'] controllertke2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] Generic_entityt'shortest-path: nsubj Gene_or_gene_productt^e2: trigger-arg-path: suppressed >dobj [lemma='expression'] >prep_of [lemma='gene'] controlledt3e2: args2Role-mention-ngram: the related CONTROLLEDt$e2: args2Role-mention-ngram: cells ,tre2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='expression'] >prep_of [lemma='gene'] Generic_entitytze1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='accumulation'] >nn [lemma='hif-1alpha'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: activity of thet3e2: args2Role-mention-ngram: represses GAP activityt!e2: ents2Label-mention-ngram: GAPt*e2: ents2Label-mention-ngram: GAP activityt,e2: args2Role-mention-ngram: activity of thet5e2: args2Role-mention-ngram: CONTROLLER represses GAPt*e2: args2Role-mention-ngram: represses GAPt e2: args2Role-mention-ngram: GAPtytrigger-to-trigger-path: e1:phosphorylation:Positive_regulation nsubj >nn theme:Familytjtrigger-to-trigger-path: e1:bind:Binding >advcl [lemma='weak'] >nsubj [lemma='binding'] e2:binding:BindingtMe1: trigger-arg-path: Binding >dobj [lemma='pi3k'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='docking'] FamilytAe2: trigger-arg-path: binding >prep_to theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED proteins ,t(e1: ents2Label-mention-ngram: preferablyt2e1: trigger-arg-path: bind >nsubj >nn theme:Familytde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3k'] theme:Gene_or_gene_producttVe1: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt#e1: ents2Label-mention-ngram: by IRt"e1: args2Role-mention-ngram: by IRtLe1: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding >prep_to Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_to [lemma='grb2-so'] theme:Gene_or_gene_producttWe1: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themetBe1: ents2Label-mention-ngram: bind preferably GENE_OR_GENE_PRODUCTtLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn theme:Familyt>e2: trigger-arg-path: binding >prep_to [lemma='grb2-so'] themet#e1: args2Role-mention-ngram: , bindt4e1: trigger-arg-path: bind:Binding >nsubj >nn Familytme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='grb2-so'] theme:Gene_or_gene_producttUe2: trigger-arg-path: binding:Binding >prep_to [lemma='grb2-so'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] Familyt'e1: args2Role-mention-ngram: preferablyt+e1: args2Role-mention-ngram: THEME proteinstYe1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt,e1: args2Role-mention-ngram: proteins , whent5e1: trigger-arg-path: Binding >nsubj >nn theme:FamilytMe2: trigger-arg-path: Binding >prep_to [lemma='grb2-so'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt3e1: args2Role-mention-ngram: when phosphorylated byt_e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='grb2-so'] Gene_or_gene_productt2e1: args2Role-mention-ngram: , when phosphorylatedt e1: ents2Label-mention-ngram: IRtSe1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] FamilytJe1: trigger-arg-path: bind >dobj [lemma='pi3k'] theme:Gene_or_gene_productt,e2: trigger-arg-path: binding >prep_to themetDe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn theme:Familyt(e1: ents2Label-mention-ngram: proteins ,t"e1: ents2Label-mention-ngram: whent^e1: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt3e1: ents2Label-mention-ngram: , when phosphorylatedt4e1: ents2Label-mention-ngram: when phosphorylated bytUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to Gene_or_gene_productt;e2: trigger-arg-path: binding >prep_to Gene_or_gene_productte1: args2Role-mention-ngram: IRtOe1: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] themetPe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='grb2-so'] themet>e2: trigger-arg-path: Binding >prep_to [lemma='grb2-so'] themetae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='docking'] themet/e1: ents2Label-mention-ngram: , bind preferablyt[e2: trigger-arg-path: binding:Binding >prep_to [lemma='grb2-so'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: proteins ,t3e1: trigger-arg-path: bind:Binding >nsubj >nn themet.e1: args2Role-mention-ngram: phosphorylated bytIe2: trigger-arg-path: binding:Binding >prep_to theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: IR ,t-e1: args2Role-mention-ngram: THEME proteins ,t4e2: trigger-arg-path: binding:Binding >prep_to themet[e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: , whent+e1: args2Role-mention-ngram: phosphorylatedtRe1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themet2e1: ents2Label-mention-ngram: phosphorylated by IRtXe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='grb2-so'] themetMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to Gene_or_gene_productt-e1: ents2Label-mention-ngram: proteins , whent&e1: args2Role-mention-ngram: IR , bindt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3k'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: when phosphorylatedt$e1: args2Role-mention-ngram: by IR ,t>e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to themetXe1: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] Familytge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='grb2-so'] Gene_or_gene_productt8e1: trigger-arg-path: Binding >dobj [lemma='pi3k'] themetSe2: trigger-arg-path: binding >prep_to [lemma='grb2-so'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: bind preferablyt=e1: ents2Label-mention-ngram: preferably GENE_OR_GENE_PRODUCTtRe1: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] theme:Gene_or_gene_productt/e1: trigger-arg-path: Binding >nsubj >nn Familyt1e1: args2Role-mention-ngram: phosphorylated by IRt#e1: args2Role-mention-ngram: , whentPe1: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] Familytee2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='grb2-so'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bind >dobj [lemma='pi3k'] Gene_or_gene_productt!e1: args2Role-mention-ngram: whent%e1: ents2Label-mention-ngram: by IR ,tie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themet+e1: trigger-arg-path: bind >nsubj >nn themet>e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn FamilytFe2: trigger-arg-path: binding:Binding >prep_to [lemma='grb2-so'] themetGe1: trigger-arg-path: Binding >dobj [lemma='pi3k'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn FamilytItrigger-to-trigger-path: e1:bind:Binding >advcl >nsubj e2:binding:Bindingt,e1: trigger-arg-path: bind >nsubj >nn Familyt'e1: ents2Label-mention-ngram: IR , bindt0e1: args2Role-mention-ngram: when phosphorylatedtGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] themethe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt~shortest-path: advcl [lemma='weak'] >nsubj [lemma='binding'] >poss [lemma='they']t!e1: args2Role-mention-ngram: IR ,tSe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to theme:Gene_or_gene_productt=e1: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3k'] themet-e1: args2Role-mention-ngram: preferably THEMEt2e1: args2Role-mention-ngram: bind preferably THEMEtFe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to themetMe2: trigger-arg-path: binding >prep_to [lemma='grb2-so'] Gene_or_gene_productt5e1: trigger-arg-path: bind >dobj [lemma='pi3k'] themet-shortest-path: advcl >nsubj >posst.e1: args2Role-mention-ngram: , bind preferablyt-e1: ents2Label-mention-ngram: bind preferablyt\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: , bindt?e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controller:Gene_or_gene_productt?e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] Gene_or_gene_productt:e1: args2Role-mention-ngram: CONTROLLER catalytic activitytTe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='map3k2'] controllert-e1: ents2Label-mention-ngram: promotes SHAREDtLe2: trigger-arg-path: Positive_regulation >nsubj [lemma='map3k2'] controllertFe1: trigger-arg-path: Positive_regulation >nsubj >appos >nn controllertVe2: trigger-arg-path: Positive_regulation >nsubj [lemma='map3k2'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controller:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >appos >nn controllert^e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='map3k2'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='map3k2'] Gene_or_gene_productt[e1: trigger-arg-path: Positive_regulation >nsubj >appos >nn controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: catalytict?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: activity promotest9e1: ents2Label-mention-ngram: catalytic activity promotest/e1: args2Role-mention-ngram: catalytic activityt'e1: ents2Label-mention-ngram: catalytictYe1: trigger-arg-path: promotes:Positive_regulation >nsubj >appos >nn Gene_or_gene_producttOe1: trigger-arg-path: promotes:Positive_regulation >nsubj >appos >nn controllert8e1: args2Role-mention-ngram: catalytic activity promotestae1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >appos >nn controller:Gene_or_gene_producttte1: trigger-arg-path: promotes >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] Gene_or_gene_producttPe1: trigger-arg-path: promotes >nsubj >appos >nn controller:Gene_or_gene_producttEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT catalytic activityt0e1: ents2Label-mention-ngram: catalytic activityt9e1: args2Role-mention-ngram: activity promotes CONTROLLEDtue1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >appos >nn controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER catalytict`e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >appos >nn controllertQe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='map3k2'] controllert?shortest-path: ccomp [lemma='induce'] >nsubj [lemma='map3k2']t;e1: trigger-arg-path: promotes >nsubj >appos >nn controllertje1: trigger-arg-path: promotes >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controllertVe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >appos >nn Gene_or_gene_producttPe1: trigger-arg-path: Positive_regulation >nsubj >appos >nn Gene_or_gene_productte1: trigger-arg-path: promotes >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controller:Gene_or_gene_productt^trigger-to-trigger-path: e1:promotes:Positive_regulation >ccomp e2:induced:Positive_regulationt0e1: args2Role-mention-ngram: promotes CONTROLLEDtUe2: trigger-arg-path: induced >nsubj [lemma='map3k2'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: activity promotes SHAREDtJe2: trigger-arg-path: induced >nsubj [lemma='map3k2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controllertotrigger-to-trigger-path: e1:promotes:Positive_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationt[e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='map3k2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: promotes SHARED inducedtae2: trigger-arg-path: Positive_regulation >nsubj [lemma='map3k2'] controller:Gene_or_gene_producttde1: trigger-arg-path: promotes:Positive_regulation >nsubj >appos >nn controller:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='map3k2'] controller:Gene_or_gene_productte1: trigger-arg-path: Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] Gene_or_gene_producttue1: trigger-arg-path: Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controllertnsubj [lemma='map3k2'] controllert?e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: activity promotestEe1: trigger-arg-path: promotes >nsubj >appos >nn Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='map3k2'] controller:Gene_or_gene_productt.shortest-path: ccomp >nsubjtje1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >appos >nn Gene_or_gene_producttie2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='map3k2'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controllert~e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] controllert?e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='d'] >appos [lemma='activity'] >nn [lemma='smyd3'] Gene_or_gene_productt@e2: trigger-arg-path: induced >nsubj [lemma='map3k2'] controllertRe2: trigger-arg-path: promote:Positive_activation nsubj controller:ComplextUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to Gene_or_gene_producttLe1: trigger-arg-path: Binding >nn [lemma='raf-1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: promote:Positive_activation nsubj [lemma='a-raf'] ComplextZe2: trigger-arg-path: promote:Positive_activation >prepc_by >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlledtGe2: trigger-arg-path: promote:Positive_activation nsubj Complextee2: trigger-arg-path: promote:Positive_activation >prepc_by >dobj >nn controlled:Gene_or_gene_productt1e2: args2Role-mention-ngram: promote the survivalt(e2: args2Role-mention-ngram: restrainingt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] Gene_or_gene_productt6e2: trigger-arg-path: promote nsubj controllert%e2: args2Role-mention-ngram: seems tot"interceding-token ngrams: mitogenst?e2: trigger-arg-path: Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] Gene_or_gene_producttie2: trigger-arg-path: Positive_activation nsubj [lemma='a-raf'] controller:Complext'interceding-token ngrams: by stress andt*e2: ents2Label-mention-ngram: and seems totJe1: trigger-arg-path: Binding >prep_to [lemma='mst2'] Gene_or_gene_productt-interceding-token ngrams: reduced by mitogenstFe1: trigger-arg-path: binding >nn [lemma='raf-1'] Gene_or_gene_producttPe2: trigger-arg-path: promote:Positive_activation >prepc_by >dobj >nn controlledt'interceding-token ngrams: is induced byt-e2: args2Role-mention-ngram: seems to promotetae2: trigger-arg-path: Positive_activation nsubj [lemma='a-raf'] controllert?e1: trigger-arg-path: binding:Binding >nn [lemma='raf-1'] themetTe1: trigger-arg-path: binding:Binding >nn [lemma='raf-1'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: cells byt#interceding-token ngrams: by stresst>e1: trigger-arg-path: lemmatizedTrigger=binding >prep_to themetFe1: trigger-arg-path: Binding >nn [lemma='raf-1'] Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: constitutively andt6e2: ents2Label-mention-ngram: constitutively and seemst3e2: ents2Label-mention-ngram: by restraining SHAREDtNe1: trigger-arg-path: binding:Binding >nn [lemma='raf-1'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='mst2'] Gene_or_gene_productt?e2: trigger-arg-path: promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='mst2'] themet,e1: trigger-arg-path: binding >prep_to themet&e2: ents2Label-mention-ngram: seems totUe2: trigger-arg-path: promote nsubj [lemma='a-raf'] controllert1e2: args2Role-mention-ngram: cells by restrainingt;e1: trigger-arg-path: binding >prep_to [lemma='mst2'] themet7e1: trigger-arg-path: binding >nn [lemma='raf-1'] themet,e2: ents2Label-mention-ngram: to promote thet?trigger-to-trigger-path: e1:binding:Binding conj_and [lemma='seem'] >xcomp [lemma='promote'] e2:promote:Positive_activationt+e2: args2Role-mention-ngram: to promote thetbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='mst2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds tot$interceding-token ngrams: induced bytPe1: trigger-arg-path: Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttLinterceding-tokens-full-span: is induced by stress and reduced by mitogens ,t0e2: ents2Label-mention-ngram: constitutively andt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='a-raf'] controller:Complext|e2: trigger-arg-path: promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation nsubj controller:Complext3e2: ents2Label-mention-ngram: SHARED constitutivelyt2e2: ents2Label-mention-ngram: promote the survivalt2e2: ents2Label-mention-ngram: cells by restrainingt'interceding-token ngrams: by mitogens ,tie2: trigger-arg-path: promote:Positive_activation nsubj [lemma='a-raf'] controllerte2: trigger: promotet*e2: ents2Label-mention-ngram: the survivalt&e2: ents2Label-mention-ngram: cells bytYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj Complext-e2: ents2Label-mention-ngram: cancer cells bytXe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf-1'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to theme:Gene_or_gene_productt>e2: trigger-arg-path: promote nsubj controller:ComplextFe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to themetLe1: trigger-arg-path: binding >nn [lemma='raf-1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to Gene_or_gene_productt?e2: trigger-arg-path: promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlledtRe1: trigger-arg-path: binding:Binding >prep_to [lemma='mst2'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf-1'] themet3e2: args2Role-mention-ngram: restraining CONTROLLEDtxe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='a-raf'] Complext5e2: args2Role-mention-ngram: constitutively and seemstSe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='a-raf'] Complext)e2: ents2Label-mention-ngram: survival oft0e2: ents2Label-mention-ngram: survival of cancertmshortest-path: nsubj [lemma='a-raf']t"e2: args2Role-mention-ngram: seemst'e2: args2Role-mention-ngram: to promotet,interceding-token ngrams: stress and reducedt/e2: args2Role-mention-ngram: survival of cancert8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bindst?e2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlledt#e2: ents2Label-mention-ngram: seemst)e2: args2Role-mention-ngram: and seems totJe1: trigger-arg-path: binding >prep_to [lemma='mst2'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlled:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by >dobj >nn Gene_or_gene_producttRe2: trigger-arg-path: Positive_activation >prepc_by >dobj >nn Gene_or_gene_producttprepc_by >dobj >nn controlledt)e2: args2Role-mention-ngram: the survivaltwe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by >dobj >nn controlled:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj controller:Complext^e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf-1'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by >dobj >nn controlledt0e2: ents2Label-mention-ngram: restraining SHAREDt~e2: trigger-arg-path: Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlledt;e1: trigger-arg-path: binding >prep_to Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation nsubj [lemma='a-raf'] Complext(e2: ents2Label-mention-ngram: to promotet$interceding-token ngrams: is inducedt\e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj controllertCe1: trigger-arg-path: binding:Binding >prep_to [lemma='mst2'] themet`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf-1'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf-1'] themet,e2: args2Role-mention-ngram: cancer cells bytge2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='a-raf'] controllert:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bindingt?e2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt(e2: args2Role-mention-ngram: survival oft$interceding-token ngrams: stress andt3e2: trigger-arg-path: promote nsubj Complext7e2: ents2Label-mention-ngram: SHARED constitutively andtHe2: trigger-arg-path: Positive_activation >prepc_by >dobj >nn controlledtje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttmtrigger-to-trigger-path: e1:binding:Binding conj_and >xcomp e2:promote:Positive_activationt.e2: ents2Label-mention-ngram: seems to promotetPe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Complext+e2: args2Role-mention-ngram: by restrainingtAe1: trigger-arg-path: binding >prep_to theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >prepc_by >dobj >nn Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='a-raf'] controller:Complext;e1: trigger-arg-path: Binding >prep_to [lemma='mst2'] themet,e2: ents2Label-mention-ngram: by restrainingtfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf-1'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: of cancer cellst6e2: args2Role-mention-ngram: by restraining CONTROLLEDtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='mst2'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=promote nsubj Complext%interceding-token ngrams: and reducedtCe1: trigger-arg-path: binding:Binding >prep_to Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binding tot)e2: ents2Label-mention-ngram: restrainingt4e1: trigger-arg-path: binding:Binding >prep_to themetFe2: trigger-arg-path: promote >prepc_by >dobj >nn Gene_or_gene_producttPe1: trigger-arg-path: binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='mst2'] themet?e2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] Gene_or_gene_productt:e2: args2Role-mention-ngram: CONTROLLER constitutively andtce2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by >dobj >nn controlled:Gene_or_gene_productt+shortest-path: nsubjt-e2: ents2Label-mention-ngram: the survival oftJe2: trigger-arg-path: promote:Positive_activation nsubj controllert&e2: args2Role-mention-ngram: and seemst]e2: trigger-arg-path: promote nsubj [lemma='a-raf'] controller:Complext'e2: ents2Label-mention-ngram: of cancert+interceding-token ngrams: induced by stresst&e2: args2Role-mention-ngram: of cancertre2: trigger-arg-path: promote >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlledt,e2: args2Role-mention-ngram: of cancer cellst6e2: args2Role-mention-ngram: CONTROLLER constitutivelyt]e2: trigger-arg-path: Positive_activation >prepc_by >dobj >nn controlled:Gene_or_gene_productt$interceding-token ngrams: mitogens ,t'e2: ents2Label-mention-ngram: and seemstRe2: trigger-arg-path: promote nsubj [lemma='a-raf'] Complext%e2: args2Role-mention-ngram: survivalt6e2: ents2Label-mention-ngram: to SHARED constitutivelytQe2: trigger-arg-path: promote >prepc_by >dobj >nn controlled:Gene_or_gene_productt(interceding-token ngrams: and reduced bytNe2: trigger-arg-path: lemmatizedTrigger=promote >prepc_by >dobj >nn controlledt,e2: args2Role-mention-ngram: the survival oftIe1: trigger-arg-path: binding:Binding >prep_to theme:Gene_or_gene_productt%interceding-token ngrams: by mitogenstqe2: trigger-arg-path: promote:Positive_activation nsubj [lemma='a-raf'] controller:Complext?e2: trigger-arg-path: promote:Positive_activation >prepc_by [lemma='restrain'] >dobj [lemma='apoptosis'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation nsubj Complext7e1: trigger-arg-path: Binding >nn [lemma='raf-1'] themet{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='a-raf'] controllert4e1: args2Role-mention-ngram: specifically with THEMEtee2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] theme:Generic_entityt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mek1'] Gene_or_gene_producttTe1: trigger-arg-path: interacts >prep_with [lemma='mek1'] theme:Gene_or_gene_productt"interceding-token ngrams: and ERK1tinterceding-token ngrams: ERK1t[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='MP-1'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='MP-1'] themetVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='mek1'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: SHARED interacts specificallyt1interceding-tokens-full-span: and ERK1 , enhancestSe2: trigger-arg-path: interaction:Binding >poss [lemma='they'] theme:Generic_entityt9e1: args2Role-mention-ngram: THEME interacts specificallyt$interceding-token ngrams: and ERK1 ,tposs [lemma='they'] themet)interceding-token ngrams: ERK1 , enhancestJe1: trigger-arg-path: interacts >nsubj [lemma='MP-1'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='MP-1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts >prep_with [lemma='mek1'] themet interceding-token ngrams: ERK1 ,t*e1: ents2Label-mention-ngram: specificallytNe1: trigger-arg-path: interacts >prep_with [lemma='mek1'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] Generic_entitytEe2: trigger-arg-path: interaction >poss [lemma='they'] Generic_entitytLe1: trigger-arg-path: Binding >prep_with [lemma='mek1'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] themet]e2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] theme:Generic_entitytRe1: trigger-arg-path: Binding >prep_with [lemma='mek1'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='MP-1'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: interacts specifically withtme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mek1'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='MP-1'] Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='MP-1'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='MP-1'] themetae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='MP-1'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='mek1'] themetLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='MP-1'] themetce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='MP-1'] Gene_or_gene_productt.e1: args2Role-mention-ngram: specifically withtXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='MP-1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] themet3e1: args2Role-mention-ngram: interacts specificallytge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mek1'] Gene_or_gene_producttMe2: trigger-arg-path: interaction:Binding >poss [lemma='they'] Generic_entitytGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='mek1'] themetPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mek1'] themet4e1: ents2Label-mention-ngram: interacts specificallyt8e1: args2Role-mention-ngram: interacts specifically withtRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='MP-1'] Gene_or_gene_productt$interceding-token ngrams: , enhancestTtrigger-to-trigger-path: e1:interacts:Binding >conj_and >dobj e2:interaction:BindingtXshortest-path: dobj [lemma='interaction'] >poss [lemma='they']tTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='MP-1'] themet)e1: args2Role-mention-ngram: specificallytXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mek1'] themet\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='mek1'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mek1'] theme:Gene_or_gene_producttKe2: trigger-arg-path: interaction >poss [lemma='they'] theme:Generic_entitytDe1: ents2Label-mention-ngram: specifically with GENE_OR_GENE_PRODUCTtDe2: trigger-arg-path: interaction:Binding >poss [lemma='they'] themet|trigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='enhance'] >dobj [lemma='interaction'] e2:interaction:BindingtPe1: trigger-arg-path: interacts >nsubj [lemma='MP-1'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: specifically witht_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] Generic_entitytIe2: trigger-arg-path: lemmatizedTrigger=decrease >nn Gene_or_gene_producttQe2: trigger-arg-path: Negative_regulation >nn [lemma='mtor'] Gene_or_gene_productt(e1: args2Role-mention-ngram: cascade andt3e1: args2Role-mention-ngram: triggers an CONTROLLEDtMe1: trigger-arg-path: triggers:Positive_regulation >nsubj >prep_of controllert(e2: args2Role-mention-ngram: decrease int)e1: ents2Label-mention-ngram: triggers ant)e1: ents2Label-mention-ngram: decrease intQe2: trigger-arg-path: decrease >nn [lemma='mtor'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: PI3K/Akt/mTORt\e2: trigger-arg-path: Negative_regulation >nn [lemma='mtor'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER activatestje1: trigger-arg-path: triggers >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] Gene_or_gene_productt,e1: args2Role-mention-ngram: and triggers antCe1: trigger-arg-path: triggers >nsubj >prep_of Gene_or_gene_producttnn Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >prep_of controller:Gene_or_gene_producttee2: trigger-arg-path: decrease:Negative_regulation >nn [lemma='mtor'] controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: decrease in CONTROLLEDt0e1: ents2Label-mention-ngram: decrease in SHAREDt7e1: ents2Label-mention-ngram: PI3K/Akt/mTOR cascade andt*e1: ents2Label-mention-ngram: and triggerst2e2: args2Role-mention-ngram: dependent decrease intbe1: trigger-arg-path: triggers:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttke1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controllertnn [lemma='mtor'] controllertue1: trigger-arg-path: triggers >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: an CONTROLLEDt/e1: ents2Label-mention-ngram: the PI3K/Akt/mTORt2e1: ents2Label-mention-ngram: in SHARED expressiontte1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controllert:e2: args2Role-mention-ngram: CONTROLLER dependent decreaset9e1: ents2Label-mention-ngram: activates the PI3K/Akt/mTORt?e2: trigger-arg-path: lemmatizedTrigger=decrease >nn controllert6e1: args2Role-mention-ngram: the PI3K/Akt/mTOR cascadet(e1: args2Role-mention-ngram: triggers ant`e1: trigger-arg-path: triggers >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controllert.e2: ents2Label-mention-ngram: SHARED dependenttue1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] Gene_or_gene_productt^trigger-to-trigger-path: e1:triggers:Positive_regulation >dobj e2:decrease:Negative_regulationt%e2: args2Role-mention-ngram: decreaset7e2: ents2Label-mention-ngram: SHARED dependent decreaset^e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controllertJe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >prep_of controllert'e2: ents2Label-mention-ngram: in SHAREDt]e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controllertVe2: trigger-arg-path: decrease:Negative_regulation >nn controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] Gene_or_gene_producttPe2: trigger-arg-path: decrease:Negative_regulation >nn [lemma='mtor'] controllertle2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn [lemma='mtor'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: dependent decreaset2e1: ents2Label-mention-ngram: cascade and triggerstSe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn controllertAe2: trigger-arg-path: decrease:Negative_regulation >nn controllertnsubj >prep_of controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: decrease in SHAREDte2: trigger: decreasetWe1: trigger-arg-path: triggers:Positive_regulation >nsubj >prep_of Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=decrease >nn controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: decreaset7e1: ents2Label-mention-ngram: SHARED dependent decreaset?e1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: decreaset'e1: ents2Label-mention-ngram: an SHAREDtGe2: trigger-arg-path: Negative_regulation >nn [lemma='mtor'] controllert0e1: ents2Label-mention-ngram: triggers an SHAREDt9e1: trigger-arg-path: triggers >nsubj >prep_of controllert2e1: args2Role-mention-ngram: PI3K/Akt/mTOR cascadet3e2: ents2Label-mention-ngram: dependent decrease int8e1: args2Role-mention-ngram: activates the PI3K/Akt/mTORt5e1: args2Role-mention-ngram: CONTROLLER activates thet3e1: ents2Label-mention-ngram: dependent decrease intNe2: trigger-arg-path: lemmatizedTrigger=decrease >nn [lemma='mtor'] controllert6e1: args2Role-mention-ngram: PI3K/Akt/mTOR cascade andt3e1: ents2Label-mention-ngram: PI3K/Akt/mTOR cascadethe1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj >prep_of Gene_or_gene_productt+e1: ents2Label-mention-ngram: PI3K/Akt/mTORt-e1: ents2Label-mention-ngram: and triggers ant'e1: ents2Label-mention-ngram: in SHAREDt~e1: trigger-arg-path: triggers:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=decrease >nn [lemma='mtor'] Gene_or_gene_productt1e1: args2Role-mention-ngram: cascade and triggerst?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] Gene_or_gene_producttZe2: trigger-arg-path: decrease:Negative_regulation >nn [lemma='mtor'] Gene_or_gene_productt$e1: args2Role-mention-ngram: cascadet?e1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='igf-ir'] controller:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj >prep_of Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn [lemma='mtor'] controllertqtrigger-to-trigger-path: e1:triggers:Positive_regulation >dobj [lemma='decrease'] e2:decrease:Negative_regulationt0e2: ents2Label-mention-ngram: dependent decreasetnsubj >prep_of controller:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nn [lemma='mtor'] controller:Gene_or_gene_productt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activates thet/e2: args2Role-mention-ngram: dependent decreaset)e1: ents2Label-mention-ngram: cascade andt)e1: args2Role-mention-ngram: and triggerst2e2: ents2Label-mention-ngram: in SHARED expressiont.e1: args2Role-mention-ngram: the PI3K/Akt/mTORt)e2: ents2Label-mention-ngram: decrease intBe2: trigger-arg-path: decrease >nn controller:Gene_or_gene_producttKe2: trigger-arg-path: decrease:Negative_regulation >nn Gene_or_gene_producttFe2: trigger-arg-path: decrease >nn [lemma='mtor'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED expression andt1e1: ents2Label-mention-ngram: an SHARED dependentt/e2: ents2Label-mention-ngram: SHARED expressiont3e1: ents2Label-mention-ngram: SHARED expression andt7e1: ents2Label-mention-ngram: the PI3K/Akt/mTOR cascadetrshortest-path: dobj [lemma='decrease'] >nn [lemma='mtor']t-e2: trigger-arg-path: decrease >nn controllertce2: trigger-arg-path: lemmatizedTrigger=decrease >nn [lemma='mtor'] controller:Gene_or_gene_producttvtrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='activate'] >agent [lemma='binding'] e2:binding:Bindingt$shortest-path: agent >nnt/interceding-token ngrams: directly activated byt:interceding-tokens-full-span: and is directly activated byt,interceding-token ngrams: directly activatedt)interceding-token ngrams: and is directlytVshortest-path: agent [lemma='binding'] >nn [lemma='ra']tQtrigger-to-trigger-path: e1:interacts:Binding >conj_and >agent e2:binding:Bindingt%interceding-token ngrams: is directlyt/interceding-token ngrams: is directly activatedtnsubj [lemma='ir'] controllertve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='ir'] Positive_regulationtce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn Gene_or_gene_producttRe2: trigger-arg-path: mediated:Positive_regulation >agent >nn Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn controller:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ir'] controller:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ir'] controllert_e2: trigger-arg-path: mediated:Positive_regulation nsubj controlled:Positive_regulationt^e2: trigger-arg-path: mediated nsubj [lemma='ir'] Positive_regulationthe2: trigger-arg-path: Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] Gene_or_gene_productt`e2: trigger-arg-path: Positive_regulation nsubj [lemma='ir'] controlledtTe2: trigger-arg-path: mediated:Positive_regulation nsubj Positive_regulationt]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_productthe2: trigger-arg-path: mediated >agent [lemma='pi3k'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttse2: trigger-arg-path: Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj controlled:Positive_regulationtOe2: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn Gene_or_gene_productt9e2: ents2Label-mention-ngram: phosphorylation is mediatedt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='ir'] controlled:Positive_regulationtptrigger-to-trigger-path: e1:induced:Positive_regulation >ccomp [lemma='mediate'] e2:mediated:Positive_regulationtee1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_producttIe2: trigger-arg-path: mediated >agent >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='ir'] controlled:Positive_regulationtRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ir'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ir'] Gene_or_gene_productt>e2: trigger-arg-path: mediated >agent >nn Gene_or_gene_producttSe2: trigger-arg-path: mediated >agent [lemma='pi3k'] >nn [lemma='erbb1'] controllertre2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='ir'] Positive_regulationtKe2: trigger-arg-path: mediated:Positive_regulation nsubj controlledt0e1: ents2Label-mention-ngram: phosphorylation istie2: trigger-arg-path: Positive_regulation nsubj [lemma='ir'] Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controllertie2: trigger-arg-path: mediated nsubj [lemma='ir'] controlled:Positive_regulationt]e2: trigger-arg-path: mediated:Positive_regulation >agent >nn controller:Gene_or_gene_producttPe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ir'] controllert7e1: ents2Label-mention-ngram: SHARED phosphorylation istKe2: trigger-arg-path: mediated nsubj controlled:Positive_regulationtBe2: trigger-arg-path: Positive_regulation nsubj controlledt7e2: ents2Label-mention-ngram: SHARED phosphorylation istQe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj Positive_regulationtVe2: trigger-arg-path: Positive_regulation nsubj controlled:Positive_regulationt}e2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='ir'] controlled:Positive_regulationtee2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj Positive_regulationt7e2: trigger-arg-path: mediated nsubj controlledt^e2: trigger-arg-path: Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controllertZe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ir'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj controlledtFe1: trigger-arg-path: induced >nsubj [lemma='ir'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='ir'] controlledtne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn controller:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ir'] Gene_or_gene_productt]e2: trigger-arg-path: mediated >agent [lemma='pi3k'] >nn [lemma='erbb1'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: phosphorylation is mediatedtUe2: trigger-arg-path: mediated nsubj [lemma='ir'] controlledt@e2: trigger-arg-path: mediated nsubj Positive_regulationtte2: trigger-arg-path: Positive_regulation nsubj [lemma='ir'] controlled:Positive_regulationtMe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ir'] controllertHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ir'] controllertfe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='ir'] controlledtie2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='ir'] controlledtqe2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='pi3k'] >nn [lemma='erbb1'] controllert0e2: ents2Label-mention-ngram: phosphorylation ist\e2: trigger-arg-path: lemmatizedTrigger=mediate nsubj controlled:Positive_regulationt|e2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='ir'] Positive_regulationtge2: trigger-arg-path: mediated:Positive_regulation >agent [lemma='pi3k'] >nn [lemma='erbb1'] controllert^trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp e2:mediated:Positive_regulationtye2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='pi3k'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='pi3k'] >nn [lemma='erbb1'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj controlledt&shortest-path: nsubj [lemma='ir'] controller:Gene_or_gene_productt1e1: trigger-arg-path: abrogates >ccomp controlledt\e2: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] controlled:Sumoylationt1e1: ents2Label-mention-ngram: abrogates basal andtKe1: trigger-arg-path: abrogates >ccomp [lemma='induce'] Positive_regulationt{e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt/e2: trigger-arg-path: induced >dobj Sumoylationt1e1: args2Role-mention-ngram: CONTROLLER abrogatestCe2: trigger-arg-path: induced:Positive_regulation >dobj Sumoylationtoe1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllertje1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp controlled:Positive_regulationtGe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:FamilytJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='tnfalpha'] FamilytYe1: trigger-arg-path: abrogates:Positive_regulation >ccomp controlled:Positive_regulationtDe2: trigger-arg-path: induced >dobj [lemma='sumoylation'] controlledtNe1: trigger-arg-path: abrogates:Positive_regulation >ccomp Positive_regulationt-e1: ents2Label-mention-ngram: abrogates basalt+e2: trigger-arg-path: induced >nsubj Familyt6e2: trigger-arg-path: induced >nsubj controller:Familyt@e2: trigger-arg-path: lemmatizedTrigger=induce >dobj Sumoylationtge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='tnfalpha'] controllerthe1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllert?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllert?e2: trigger-arg-path: induced:Positive_regulation >nsubj Familyt_e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of controllertNe1: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of controllertUe1: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] Positive_regulationtOe1: trigger-arg-path: Positive_regulation >ccomp controlled:Positive_regulationt1e1: args2Role-mention-ngram: basal and CONTROLLEDtKe1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of controllertde2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='sumoylation'] controlled:Sumoylationtptrigger-to-trigger-path: e1:abrogates:Positive_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationtBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT abrogates basaltge1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] controlledtce1: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttse1: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttVe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='tnfalpha'] controllertEe2: trigger-arg-path: induced >dobj [lemma='sumoylation'] Sumoylationt[e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj controller:FamilytLe1: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] controlledt0e1: args2Role-mention-ngram: abrogates basal andt_e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp Positive_regulationtJe2: trigger-arg-path: induced:Positive_regulation >nsubj controller:Familythe1: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='sumoylation'] SumoylationtUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='tnfalpha'] controller:FamilytVe1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp controlled:Positive_regulationtSe1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] controlledtQe2: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] Sumoylationt`e1: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt.e1: ents2Label-mention-ngram: basal and SHAREDtSe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='tnfalpha'] controllertae2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='sumoylation'] controlled:Sumoylationt0e2: ents2Label-mention-ngram: SHARED sumoylationtKe1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp Positive_regulationtRe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='tnfalpha'] Familyt_e1: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] Positive_regulationtXe2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='sumoylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_productt:e2: trigger-arg-path: induced >dobj controlled:SumoylationtEe1: trigger-arg-path: abrogates >ccomp controlled:Positive_regulationtre1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttdobj controlled:Sumoylationt&e1: args2Role-mention-ngram: basal andtUe1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of Gene_or_gene_producttre1: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllert|e1: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp controlledtne2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='tnfalpha'] controller:Familyt:e1: trigger-arg-path: abrogates >nsubj >prep_of controllertwshortest-path: ccomp [lemma='induce'] >nsubj [lemma='tnfalpha']tye1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] Positive_regulationt}e1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='sumoylation'] controlledtVe1: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] controlledt7e2: trigger-arg-path: Positive_regulation >nsubj Familytce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='tnfalpha'] Familyt8e1: ents2Label-mention-ngram: induced SHARED sumoylationt?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: basal andtge1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] controlled:Positive_regulationtOe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='tnfalpha'] Familyt_trigger-to-trigger-path: e1:abrogates:Positive_regulation >ccomp e2:induced:Positive_regulationtIe2: trigger-arg-path: induced >nsubj [lemma='tnfalpha'] controller:FamilytNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='tnfalpha'] controllert:e1: trigger-arg-path: abrogates >ccomp Positive_regulationtTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj Sumoylationtie1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of Gene_or_gene_productt^e1: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllert7e1: args2Role-mention-ngram: CONTROLLER abrogates basalt?e1: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp controlledte1: trigger: abrogatestEe1: trigger-arg-path: abrogates:Positive_regulation >ccomp controlledtBe2: trigger-arg-path: Positive_regulation >nsubj controller:Familytje1: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttBe1: trigger-arg-path: abrogates >ccomp [lemma='induce'] controlledt\e1: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] Positive_regulationtBe2: trigger-arg-path: induced >nsubj [lemma='tnfalpha'] controllertPe2: trigger-arg-path: induced >dobj [lemma='sumoylation'] controlled:SumoylationtVe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='sumoylation'] SumoylationtOe1: trigger-arg-path: abrogates >nsubj >prep_of controller:Gene_or_gene_productt>e2: trigger-arg-path: induced >nsubj [lemma='tnfalpha'] Familyt"e1: args2Role-mention-ngram: basaltDe1: trigger-arg-path: abrogates >nsubj >prep_of Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj Familytnsubj FamilytPe2: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] controlledt#e1: ents2Label-mention-ngram: basalt,e1: args2Role-mention-ngram: abrogates basalt&e1: args2Role-mention-ngram: abrogatest0e1: ents2Label-mention-ngram: and SHARED inducedtie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='sumoylation'] controlledtFe2: trigger-arg-path: Positive_regulation >dobj controlled:SumoylationtDe1: trigger-arg-path: Positive_regulation >ccomp Positive_regulationtXe1: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='sumoylation'] controlled:SumoylationtZe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='tnfalpha'] controller:Familyt8e2: ents2Label-mention-ngram: induced SHARED sumoylationt`e1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: abrogatestYe2: trigger-arg-path: induced:Positive_regulation >dobj [lemma='sumoylation'] SumoylationtKe2: trigger-arg-path: lemmatizedTrigger=induce >dobj controlled:Sumoylationt)e2: ents2Label-mention-ngram: sumoylationt;e2: trigger-arg-path: Positive_regulation >dobj SumoylationtNe2: trigger-arg-path: induced:Positive_regulation >dobj controlled:SumoylationtVe1: trigger-arg-path: abrogates >ccomp [lemma='induce'] controlled:Positive_regulationt]e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='tnfalpha'] controller:Familyt0e1: args2Role-mention-ngram: also inhibits c-juntPe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] controllertee1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: c-jun phosphorylation ,t1e1: ents2Label-mention-ngram: thus dispersing thet3e1: ents2Label-mention-ngram: dispersing the SHAREDt+e1: args2Role-mention-ngram: inhibits c-junt2e1: args2Role-mention-ngram: c-jun phosphorylationt,e1: ents2Label-mention-ngram: dispersing thetBe1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT heterodimert.e1: args2Role-mention-ngram: phosphorylation ,t>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT heterodimertHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] controllert3e1: ents2Label-mention-ngram: c-jun phosphorylationtZe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: thustke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: , thus dispersingt;e1: args2Role-mention-ngram: inhibits c-jun phosphorylationt6e1: args2Role-mention-ngram: dispersing the CONTROLLEDt)e1: ents2Label-mention-ngram: heterodimert$e1: ents2Label-mention-ngram: , thust0e1: args2Role-mention-ngram: thus dispersing thet#e1: ents2Label-mention-ngram: c-junt"e1: args2Role-mention-ngram: c-juntae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] controllert3e1: args2Role-mention-ngram: phosphorylation , thustptrigger-to-trigger-path: e1:induced:Positive_regulation >ccomp [lemma='inhibit'] e2:inhibits:Positive_regulationt4e1: ents2Label-mention-ngram: phosphorylation , thust5e1: ents2Label-mention-ngram: c-jun phosphorylation ,t^trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp e2:inhibits:Positive_regulationt,e1: args2Role-mention-ngram: thus dispersingt'e1: args2Role-mention-ngram: dispersingt(e1: ents2Label-mention-ngram: dispersingt/e1: ents2Label-mention-ngram: phosphorylation ,t,e1: ents2Label-mention-ngram: inhibits c-junt#e1: args2Role-mention-ngram: , thust!e1: args2Role-mention-ngram: thustve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: dispersing thet1e1: ents2Label-mention-ngram: also inhibits c-junt.e1: args2Role-mention-ngram: , thus dispersingtRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: thus dispersingt]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_producttdobj [lemma='pathway'] >nn [lemma='arf'] controlledtCe2: trigger-arg-path: positively regulates dobj >nn Familyt2e1: ents2Label-mention-ngram: which directly bindst?e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn themet5e1: trigger-arg-path: binds >prep_to >nn theme:Familyt@e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn Familytye2: trigger-arg-path: Positive_activation dobj [lemma='pathway'] >nn [lemma='arf'] controlledtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='promoter'] >nn [lemma='arf'] theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=positively regulate dobj [lemma='pathway'] >nn [lemma='arf'] FamilytNe1: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='pathway'] >nn [lemma='arf'] controlled:Familyt5e2: ents2Label-mention-ngram: promoter and positivelyt-e1: args2Role-mention-ngram: , which directlyt?e2: trigger-arg-path: positively regulates:Positive_activation dobj [lemma='pathway'] >nn [lemma='arf'] controlledtLe2: trigger-arg-path: positively regulates dobj [lemma='pathway'] >nn [lemma='arf'] FamilytKe2: trigger-arg-path: Positive_activation dobj >nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=positively regulate dobj [lemma='pathway'] >nn [lemma='arf'] controlled:Familyt e2: args2Role-mention-ngram: p19t.e1: args2Role-mention-ngram: directly binds tot@e2: trigger-arg-path: Positive_activation dobj >nn controlled:Familyt9e1: trigger-arg-path: lemmatizedTrigger=bind prep_to >nn themet7e1: trigger-arg-path: Binding >prep_to >nn theme:Familyt1e1: args2Role-mention-ngram: which directly bindst+e1: ents2Label-mention-ngram: to the SHAREDtAe2: trigger-arg-path: positively regulates dobj [lemma='pathway'] >nn [lemma='arf'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation prep_to >nn themetbe2: trigger-arg-path: Positive_activation prep_to >nn Familyt+e2: args2Role-mention-ngram: p19 CONTROLLEDt7e1: trigger-arg-path: binds dobj >nn controlledtGe2: trigger-arg-path: positively regulates dobj >nn controlledtme2: trigger-arg-path: Positive_activation prep_to >nn FamilytWe1: trigger-arg-path: lemmatizedTrigger=bind prep_to [lemma='promoter'] >nn [lemma='arf'] Familyt4e2: args2Role-mention-ngram: CONTROLLER promoter andthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='arf'] themet?e2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation dobj [lemma='pathway'] >nn [lemma='arf'] controlled:FamilytNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to >nn theme:FamilytAe1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='promoter'] >nn [lemma='arf'] FamilytQe1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='arf'] themet.e2: args2Role-mention-ngram: regulates the p19t7e1: trigger-arg-path: binds dobj >nn Familyt5e2: args2Role-mention-ngram: positively regulates thet%e2: ents2Label-mention-ngram: the p19t(e2: ents2Label-mention-ngram: positivelyt.e2: ents2Label-mention-ngram: , which directlytFe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation dobj >nn Familyt'e2: args2Role-mention-ngram: positivelytae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='arf'] Familyt=e1: trigger-arg-path: binds:Binding >prep_to >nn theme:Familyt!e2: trigger: positively regulatest9e1: trigger-arg-path: Binding dobj [lemma='pathway'] >nn [lemma='arf'] controlled:FamilytXe2: trigger-arg-path: positively regulates:Positive_activation dobj >nn controlled:Familyt$e2: args2Role-mention-ngram: the p19tee1: trigger-arg-path: lemmatizedTrigger=bind:Binding dobj >nn controlled:Familyt1e1: trigger-arg-path: Binding >prep_to >nn Familytle2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation dobj >nn controlledtTe1: trigger-arg-path: binds:Binding prep_to [lemma='promoter'] >nn [lemma='arf'] theme:Familytie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='arf'] Familyt,e1: ents2Label-mention-ngram: which directlytne2: trigger-arg-path: positively regulates prep_to >nn themet%e2: args2Role-mention-ngram: promotert,e1: ents2Label-mention-ngram: SHARED , whicht?e2: trigger-arg-path: lemmatizedTrigger=positively regulate dobj [lemma='pathway'] >nn [lemma='arf'] controlledtFe2: trigger-arg-path: Positive_activation dobj >nn controlledtfe2: trigger-arg-path: positively regulates dobj >nn Familyt_trigger-to-trigger-path: e1:binds:Binding >conj_and e2:positively regulates:Positive_activationt`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='arf'] themet/e1: trigger-arg-path: binds >prep_to >nn FamilytMe2: trigger-arg-path: Positive_activation dobj >nn controlled:Familyt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='promoter'] >nn [lemma='arf'] themetoe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='arf'] theme:Familytce2: trigger-arg-path: positively regulates prep_to [lemma='promoter'] >nn [lemma='arf'] theme:FamilytPe1: trigger-arg-path: binds >prep_to [lemma='promoter'] >nn [lemma='arf'] Familytie2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation prep_to [lemma='promoter'] >nn [lemma='arf'] theme:Familyt4e2: args2Role-mention-ngram: promoter and positivelytse2: trigger-arg-path: lemmatizedTrigger=positively regulate:Positive_activation dobj >nn controlled:Familyt.e1: ents2Label-mention-ngram: , which directlyt+e2: ents2Label-mention-ngram: to the SHAREDtOe1: trigger-arg-path: binds >prep_to [lemma='promoter'] >nn [lemma='arf'] themetwe2: trigger-arg-path: lemmatizedTrigger=positively regulate conj_and [lemma='regulate'] e2:positively regulates:Positive_activationtve2: trigger-arg-path: positively regulates dobj [lemma='pathway'] >nn [lemma='arf'] FamilytGe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to >nn themet?e2: trigger-arg-path: Positive_activation dobj [lemma='pathway'] >nn [lemma='arf'] controlled:Familyt&e2: ents2Label-mention-ngram: promotertze2: trigger-arg-path: positively regulates dobj [lemma='pathway'] >nn [lemma='arf'] controlledt,e2: ents2Label-mention-ngram: the p19 SHAREDt?e2: trigger-arg-path: positively regulates:Positive_activation dobj [lemma='pathway'] >nn [lemma='arf'] FamilytNe1: trigger-arg-path: Binding dobj >nn controlledt,e2: ents2Label-mention-ngram: which directlyt]e2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of >prep_with Gene_or_gene_productt(e2: args2Role-mention-ngram: Hif2alpha )tTe2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] Gene_or_gene_producttprep_of >prep_with themetYe2: trigger-arg-path: dimerization:Binding >prep_of >prep_with theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of >prep_with themet[e1: trigger-arg-path: requires >nsubj [lemma='transcription'] >nn [lemma='hif1'] controllertMe2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] themetZe2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: Hif2alpha ) withtJe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dependent transcriptiontUe2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: or Hif2alpha )t}e2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] themet>e1: ents2Label-mention-ngram: dependent transcription requirestmtrigger-to-trigger-path: e1:requires:Positive_regulation >dobj [lemma='dimerization'] e2:dimerization:BindingtCe2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of themet@e2: trigger-arg-path: dimerization >prep_of Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] >nn [lemma='hif1'] Gene_or_gene_productt+e2: args2Role-mention-ngram: or Hif2alpha )te2: outgoing: >pobjt=e1: args2Role-mention-ngram: dependent transcription requirestVtrigger-to-trigger-path: e1:requires:Positive_regulation >dobj e2:dimerization:Bindingt,e2: ents2Label-mention-ngram: ( or Hif2alphat.e1: ents2Label-mention-ngram: Hif2alpha ) witht{e1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: ( or Hif2alphat$e1: ents2Label-mention-ngram: ) witht^e2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] themet4e1: args2Role-mention-ngram: dependent transcriptiontSe2: trigger-arg-path: dimerization:Binding >prep_of >prep_with Gene_or_gene_producttre2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: Hif2alpha )tpe1: trigger-arg-path: requires >nsubj [lemma='transcription'] >nn [lemma='hif1'] controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: ) with THEMEtprep_of >prep_with themetee2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of >prep_with Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of themetye1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: requires thetke2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] themet*e2: ents2Label-mention-ngram: dimerizationtfe2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] themetbe2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: requires the CONTROLLEDt+e2: ents2Label-mention-ngram: ) with SHAREDt$e2: ents2Label-mention-ngram: ) witht'e2: args2Role-mention-ngram: THEME ( ort`e2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of theme:Gene_or_gene_productt?e1: args2Role-mention-ngram: CONTROLLER dependent transcriptiont*e1: ents2Label-mention-ngram: or Hif2alphatse2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] theme:Gene_or_gene_producttHe2: trigger-arg-path: dimerization:Binding >prep_of Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] Gene_or_gene_productt$e2: args2Role-mention-ngram: THEME (tke2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of >prep_with theme:Gene_or_gene_productt?e1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] theme:Gene_or_gene_productte2: trigger: dimerizationtle1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] >nn [lemma='hif1'] controllertKe2: trigger-arg-path: dimerization >prep_of >prep_with Gene_or_gene_productt*e2: ents2Label-mention-ngram: or Hif2alphatQe2: trigger-arg-path: dimerization >prep_of >prep_with theme:Gene_or_gene_producttze2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] Gene_or_gene_producttDe2: trigger-arg-path: dimerization:Binding >prep_of >prep_with themetce2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] themetZe2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of Gene_or_gene_productt4e2: ents2Label-mention-ngram: dimerization of SHAREDt7e1: ents2Label-mention-ngram: requires the dimerizationt'e2: ents2Label-mention-ngram: Hif2alphat7e1: args2Role-mention-ngram: transcription requires thet-e2: ents2Label-mention-ngram: dimerization oft&e2: args2Role-mention-ngram: Hif2alphat1e2: trigger-arg-path: dimerization >prep_of themet1e1: ents2Label-mention-ngram: the dimerization oft9e2: trigger-arg-path: dimerization:Binding >prep_of themetxe2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: ) withtfe1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controllert`shortest-path: dobj [lemma='dimerization']tce2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of >prep_with theme:Gene_or_gene_producttpe1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] Gene_or_gene_productt!e2: args2Role-mention-ngram: ( ortee1: trigger-arg-path: requires >nsubj [lemma='transcription'] >nn [lemma='hif1'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: ) with SHAREDtme2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: of THEME (t.e2: ents2Label-mention-ngram: Hif2alpha ) witht,e2: args2Role-mention-ngram: dimerization oftle2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] theme:Gene_or_gene_producttNe2: trigger-arg-path: dimerization:Binding >prep_of theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: SHARED ( ort.e1: ents2Label-mention-ngram: the dimerizationt,e1: ents2Label-mention-ngram: or Hif2alpha )t\e2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] themet2e2: args2Role-mention-ngram: dimerization of THEMEt)e2: ents2Label-mention-ngram: Hif2alpha )t?e1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='transcription'] >nn [lemma='hif1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] Gene_or_gene_productt3e1: args2Role-mention-ngram: transcription requirest)e2: args2Role-mention-ngram: dimerizationte1: outgoing: >pobjt?e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] theme:Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_of [lemma='hif1alpha'] themet,e1: ents2Label-mention-ngram: ( or Hif2alphat4e1: ents2Label-mention-ngram: transcription requirest1e1: args2Role-mention-ngram: CONTROLLER dependentt8e1: ents2Label-mention-ngram: transcription requires thet?e2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] >prep_with [lemma='hif1beta'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of [lemma='hif1alpha'] themet-e1: ents2Label-mention-ngram: dimerization oft5e1: ents2Label-mention-ngram: dependent transcriptiont'e1: ents2Label-mention-ngram: Hif2alphatRe2: trigger-arg-path: lemmatizedTrigger=dimerization >prep_of Gene_or_gene_producttEe2: trigger-arg-path: dimerization >prep_of [lemma='hif1alpha'] themet)e2: args2Role-mention-ngram: or Hif2alphat4e1: ents2Label-mention-ngram: dimerization of SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controllertne2: trigger-arg-path: lemmatizedTrigger=dimerization:Binding >prep_of [lemma='hif1alpha'] Gene_or_gene_producttoe1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='transcription'] >nn [lemma='hif1'] controllertFe2: trigger-arg-path: dimerization >prep_of theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: SHARED ( ortRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tp53'] themet2e1: ents2Label-mention-ngram: promotes degradationtBe1: trigger-arg-path: promotes dobj >prep_of controlledtLe1: trigger-arg-path: promotes:Negative_activation >dobj >prep_of controlledtVe1: trigger-arg-path: promotes:Negative_activation nsubj [lemma='ubiquitin'] theme:FamilytAe2: trigger-arg-path: binds:Binding >prep_to [lemma='tp53'] themet+e1: ents2Label-mention-ngram: MDM2 binds totStrigger-to-trigger-path: e1:promotes:Negative_activation nsubj [lemma='ubiquitin'] theme:Familyt4e1: args2Role-mention-ngram: CONTROLLER and promotest>e1: trigger-arg-path: Negative_activation nsubj [lemma='ubiquitin'] themet3e1: trigger-arg-path: promotes prep_to [lemma='tp53'] theme:Gene_or_gene_productt8e1: trigger-arg-path: promotes >dobj >prep_of controlledt?e1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: MDM2 bindst|e1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: promotes:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: Binding >nsubj [lemma='ubiquitin'] Familyt/e2: ents2Label-mention-ngram: SHARED MDM2 bindst1e1: args2Role-mention-ngram: promotes degradationtJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tp53'] themetPe1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='ubiquitin'] themetIe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >prep_of controlledt+e1: args2Role-mention-ngram: degradation oftge1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlledtNe2: trigger-arg-path: binds >prep_to [lemma='tp53'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation prep_to [lemma='tp53'] Gene_or_gene_producttbtrigger-to-trigger-path: e1:promotes:Negative_activation nsubj [lemma='ubiquitin'] theme:FamilytCe2: trigger-arg-path: binds >nsubj [lemma='ubiquitin'] theme:FamilytDe2: trigger-arg-path: binds:Binding >nsubj [lemma='ubiquitin'] themetEe2: trigger-arg-path: binds:Binding >nsubj [lemma='ubiquitin'] Familytae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tp53'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >prep_of controlledt6e1: ents2Label-mention-ngram: and promotes degradationtoe1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation dobj [lemma='degradation'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlled:Gene_or_gene_producttfe1: trigger-arg-path: promotes >dobj [lemma='degradation'] >prep_of [lemma='p53'] Gene_or_gene_producttze1: trigger-arg-path: promotes:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt&shortest-path: dobj >prep_of controlled:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tp53'] Gene_or_gene_producttMe1: trigger-arg-path: Negative_activation >dobj >prep_of Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='degradation'] >prep_of [lemma='p53'] Gene_or_gene_producttMe1: trigger-arg-path: promotes >dobj >prep_of controlled:Gene_or_gene_productt9e2: trigger-arg-path: binds >prep_to [lemma='tp53'] themet!e2: args2Role-mention-ngram: MDM2tGe1: trigger-arg-path: promotes:Negative_activation prep_to [lemma='tp53'] theme:Gene_or_gene_productt;e1: trigger-arg-path: promotes dobj [lemma='degradation'] >prep_of [lemma='p53'] controlledtae1: trigger-arg-path: promotes:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tp53'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tp53'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: MDM2 binds totVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ubiquitin'] FamilytAe1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='ubiquitin'] theme:Familyt;e1: trigger-arg-path: Negative_activation prep_to [lemma='tp53'] themet?e1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] Gene_or_gene_producttMe1: trigger-arg-path: Negative_activation e2: trigger-arg-path: Binding >nsubj [lemma='ubiquitin'] themet"e1: ents2Label-mention-ngram: MDM2tge1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlledt6e1: args2Role-mention-ngram: degradation of CONTROLLEDtFe1: trigger-arg-path: Negative_activation dobj >prep_of Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='degradation'] >prep_of [lemma='p53'] controlledt4e1: args2Role-mention-ngram: promotes degradation oftPe2: trigger-arg-path: binds:Binding >prep_to [lemma='tp53'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED MDM2 bindstqe1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='p53'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='ubiquitin'] themetNe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ubiquitin'] Familyt1e1: ents2Label-mention-ngram: SHARED and promotest(e2: ents2Label-mention-ngram: MDM2 bindstSe1: trigger-arg-path: promotes:Negative_activation dobj [lemma='degradation'] >prep_of [lemma='p53'] controlledt)e1: ents2Label-mention-ngram: SHARED MDM2t+e1: ents2Label-mention-ngram: to SHARED andt-e2: args2Role-mention-ngram: THEME MDM2 bindstJe1: trigger-arg-path: promotes prep_to [lemma='tp53'] Gene_or_gene_productt'e2: args2Role-mention-ngram: MDM2 bindstOe1: trigger-arg-path: promotes:Negative_activation nsubj [lemma='ubiquitin'] Familyt^e1: trigger-arg-path: lemmatizedTrigger=promote >dobj >prep_of controlled:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation nn [lemma='keap1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] themetEe2: trigger-arg-path: Binding >nn [lemma='nrf2'] Gene_or_gene_productt#interceding-token ngrams: increasest7e2: trigger-arg-path: binding >nn [lemma='keap1'] themet]e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binding >nn [lemma='keap1'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:phosphorylation:Positive_regulation dobj [lemma='binding'] e2:binding:Bindingt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='keap1'] Gene_or_gene_productt6e2: trigger-arg-path: binding >nn [lemma='nrf2'] themetMe2: trigger-arg-path: binding:Binding >nn [lemma='nrf2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='keap1'] themetfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='keap1'] theme:Gene_or_gene_productt_trigger-to-trigger-path: e1:phosphorylation:Positive_regulation dobj e2:binding:BindingtXe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] Gene_or_gene_producttEe2: trigger-arg-path: binding >nn [lemma='nrf2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='nrf2'] Gene_or_gene_producttNe2: trigger-arg-path: binding:Binding >nn [lemma='keap1'] Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding >nn [lemma='keap1'] themetKe2: trigger-arg-path: Binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='nrf2'] themet_e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] Gene_or_gene_producttKe2: trigger-arg-path: binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttFe2: trigger-arg-path: binding >nn [lemma='keap1'] Gene_or_gene_productt7e2: trigger-arg-path: Binding >nn [lemma='keap1'] themet6e2: trigger-arg-path: Binding >nn [lemma='nrf2'] themet>e2: trigger-arg-path: binding:Binding >nn [lemma='nrf2'] themetFe2: trigger-arg-path: Binding >nn [lemma='keap1'] Gene_or_gene_producttTshortest-path: dobj [lemma='binding'] >nn [lemma='keap1']t'interceding-tokens-full-span: increasestSe2: trigger-arg-path: binding:Binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='keap1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] themetye2: trigger-arg-path: Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] ComplextKe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj >amod ComplextJe1: trigger-arg-path: binds >nsubj [lemma='ikkalpha'] Gene_or_gene_productt#e2: args2Role-mention-ngram: domaint_e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj >amod Complext3e2: ents2Label-mention-ngram: enzymatic activity oft+e2: args2Role-mention-ngram: its HAT domaint/e2: ents2Label-mention-ngram: binds directly tot?e2: trigger-arg-path: enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] Complext?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controllert?e2: trigger-arg-path: Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controller:Complext&e2: args2Role-mention-ngram: domain attOe1: trigger-arg-path: Binding >prep_to [lemma='cbp'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binds >prep_to [lemma='cbp'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: domain att.e1: args2Role-mention-ngram: directly to THEMEt3e2: args2Role-mention-ngram: the enzymatic activitytXe2: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlledtIe1: trigger-arg-path: Binding >prep_to [lemma='cbp'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: phosphorylates its HATtXe1: trigger-arg-path: binds:Binding >nsubj [lemma='ikkalpha'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >nsubj [lemma='ikkalpha'] theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: enhance the enzymatictce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ikkalpha'] Gene_or_gene_producttDe2: trigger-arg-path: enhance nsubj >amod controller:Complext%e2: ents2Label-mention-ngram: its HATtde2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlledt|e2: trigger-arg-path: Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controllert'shortest-path: dobj >prep_of controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: directly to SHAREDt,e2: ents2Label-mention-ngram: at Ser1382 andtbe2: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] Gene_or_gene_productt3e2: args2Role-mention-ngram: activity of CONTROLLEDt$e2: args2Role-mention-ngram: Ser1382t+e2: args2Role-mention-ngram: at Ser1382 andtUe1: trigger-arg-path: binds:Binding >prep_to [lemma='cbp'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controller:Complextae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ikkalpha'] theme:Gene_or_gene_productt?e2: trigger-arg-path: enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controller:Complext'e2: ents2Label-mention-ngram: enzymatict@e1: trigger-arg-path: binds:Binding >prep_to [lemma='cbp'] themetLe2: trigger-arg-path: enhance >dobj >prep_of controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controller:ComplextQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cbp'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cbp'] themet)e2: ents2Label-mention-ngram: and Ser1386tve2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] Gene_or_gene_productt&e2: args2Role-mention-ngram: enzymatictPe2: trigger-arg-path: enhance:Positive_activation nsubj >amod controllert*e2: args2Role-mention-ngram: HAT domain attMe2: trigger-arg-path: Positive_activation >dobj >prep_of Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlled:Gene_or_gene_producttne2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation nsubj >amod controller:Complext.e2: args2Role-mention-ngram: domain at Ser1382tKe2: trigger-arg-path: enhance:Positive_activation >dobj >prep_of controlledt9e2: trigger-arg-path: enhance nsubj >amod Complext0e2: ents2Label-mention-ngram: activity of SHAREDtXe2: trigger-arg-path: enhance:Positive_activation nsubj >amod controller:Complext+e2: args2Role-mention-ngram: to enhance thet,e2: ents2Label-mention-ngram: to enhance thetOtrigger-to-trigger-path: e1:binds:Binding >xcomp e2:enhance:Positive_activationt4e2: ents2Label-mention-ngram: and phosphorylates itstCe1: trigger-arg-path: binds:Binding >nsubj [lemma='ikkalpha'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ikkalpha'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED binds directlytxe2: trigger-arg-path: enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controller:Complext'e2: args2Role-mention-ngram: at Ser1382tpe2: trigger-arg-path: enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controllert3e1: ents2Label-mention-ngram: SHARED binds directlytje2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlledt)e2: ents2Label-mention-ngram: Ser1382 andtIe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of controlledt+e2: ents2Label-mention-ngram: HAT domain attme2: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlled:Gene_or_gene_productt8e1: trigger-arg-path: binds >prep_to [lemma='cbp'] themetUe2: trigger-arg-path: enhance:Positive_activation >dobj >prep_of Gene_or_gene_producttCe2: trigger-arg-path: Positive_activation >dobj >prep_of controlledte2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] Complextnsubj >amod controllert'e2: args2Role-mention-ngram: HAT domaint^e2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: directly to SHAREDt/e2: args2Role-mention-ngram: Ser1386 to enhancet$e2: args2Role-mention-ngram: its HATt,e2: ents2Label-mention-ngram: and Ser1386 tot?e2: trigger-arg-path: lemmatizedTrigger=enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controllert)e2: ents2Label-mention-ngram: directly tot(e2: args2Role-mention-ngram: and Ser1386t/e2: args2Role-mention-ngram: enzymatic activitytre2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt7e2: trigger-arg-path: enhance >dobj >prep_of controlledt(e2: ents2Label-mention-ngram: at Ser1382t!e2: ents2Label-mention-ngram: HATtTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='ikkalpha'] themet[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ikkalpha'] Gene_or_gene_producttatrigger-to-trigger-path: e1:binds:Binding >xcomp [lemma='enhance'] e2:enhance:Positive_activationt+e2: args2Role-mention-ngram: and Ser1386 totRe1: trigger-arg-path: binds:Binding >nsubj [lemma='ikkalpha'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: Ser1386t4e2: ents2Label-mention-ngram: the enzymatic activitytSe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of Gene_or_gene_productt(e2: ents2Label-mention-ngram: HAT domaintfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cbp'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlled:Gene_or_gene_producttAe2: trigger-arg-path: enhance >dobj >prep_of Gene_or_gene_productt)e2: ents2Label-mention-ngram: enhance thet3e2: args2Role-mention-ngram: phosphorylates its HATt1e2: ents2Label-mention-ngram: Ser1382 and Ser1386t0e2: ents2Label-mention-ngram: Ser1386 to enhancet,e2: ents2Label-mention-ngram: binds directlytVe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj >amod controller:Complext;e1: trigger-arg-path: binds >nsubj [lemma='ikkalpha'] themet*e2: args2Role-mention-ngram: the enzymatict2e2: args2Role-mention-ngram: enzymatic activity oft0e2: ents2Label-mention-ngram: enzymatic activitytje2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj >amod controller:ComplextPe1: trigger-arg-path: binds >nsubj [lemma='ikkalpha'] theme:Gene_or_gene_producttMe2: trigger-arg-path: enhance:Positive_activation nsubj >amod Complext=e1: trigger-arg-path: Binding >nsubj [lemma='ikkalpha'] themetEe2: trigger-arg-path: Positive_activation nsubj >amod Complext(e2: args2Role-mention-ngram: Ser1382 andt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cbp'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] Complext$e2: args2Role-mention-ngram: enhancetLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='ikkalpha'] themet'e2: args2Role-mention-ngram: Ser1386 tot$e2: args2Role-mention-ngram: Ser1386t?e2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlled:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlledtLe1: trigger-arg-path: Binding >nsubj [lemma='ikkalpha'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: enhance the enzymatict e2: args2Role-mention-ngram: HATtte2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='cbp'] Gene_or_gene_productte2: trigger: enhancet/e2: ents2Label-mention-ngram: domain at Ser1382t?e2: trigger-arg-path: enhance:Positive_activation nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] controllertbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation nsubj >amod controllert?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: to enhancetXe2: trigger-arg-path: Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt7e2: ents2Label-mention-ngram: SHARED and phosphorylatest/e2: args2Role-mention-ngram: phosphorylates itst:e1: trigger-arg-path: Binding >prep_to [lemma='cbp'] themetme2: trigger-arg-path: enhance nsubj [lemma='ikkalpha'] >amod [lemma='nuclear'] ComplextXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cbp'] Gene_or_gene_productt'e2: args2Role-mention-ngram: to enhancet(e2: args2Role-mention-ngram: enhance thet]e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of controlledt%e2: ents2Label-mention-ngram: Ser1382tshortest-path: prep_to [lemma='cbp'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=enhance nsubj >amod controllert+e2: ents2Label-mention-ngram: the enzymatict`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cbp'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: its HAT domaintHe2: trigger-arg-path: Positive_activation nsubj >amod controllert1e1: args2Role-mention-ngram: THEME binds directlytle2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlledtye2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='cbp'] controlled:Gene_or_gene_productt0e2: args2Role-mention-ngram: Ser1382 and Ser1386t3e2: args2Role-mention-ngram: and phosphorylates itst:e2: args2Role-mention-ngram: CONTROLLER and phosphorylatest0e2: ents2Label-mention-ngram: phosphorylates itstge2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >prep_to [lemma='cbp'] Gene_or_gene_producttqe1: trigger-arg-path: stimulate:Positive_regulation amod [lemma='neurofibromin'] controllert{e1: trigger-arg-path: stimulate:Positive_regulation amod [lemma='neurofibromin'] Gene_or_gene_productt-e1: args2Role-mention-ngram: CONTROLLER ( Nf1t.e1: ents2Label-mention-ngram: and formation oftIe1: trigger-arg-path: lemmatizedTrigger=stimulate amod controllert?e1: trigger-arg-path: stimulate:Positive_regulation amod [lemma='neurofibromin'] controller:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=stimulate amod Gene_or_gene_productt3e1: ents2Label-mention-ngram: formation of inactivet]e1: trigger-arg-path: stimulate amod [lemma='neurofibromin'] controllert/e1: ents2Label-mention-ngram: , which stimulatet)e1: ents2Label-mention-ngram: of inactivet$e1: args2Role-mention-ngram: ( Nf1 )t?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod [lemma='neurofibromin'] controller:Gene_or_gene_productt7e1: args2Role-mention-ngram: which stimulate CONTROLLEDtVe1: trigger-arg-path: Positive_regulation amod controller:Gene_or_gene_producttge1: trigger-arg-path: stimulate amod [lemma='neurofibromin'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: which stimulate SHAREDt9e1: ents2Label-mention-ngram: stimulate SHARED hydrolysist3e2: ents2Label-mention-ngram: formation of inactivet]e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod controllert%shortest-path: rcmod >dobj >nnt0e1: ents2Label-mention-ngram: of inactive SHAREDtqe1: trigger-arg-path: Positive_regulation amod [lemma='neurofibromin'] Gene_or_gene_producttre1: trigger-arg-path: stimulate amod [lemma='neurofibromin'] controller:Gene_or_gene_producttge1: trigger-arg-path: Positive_regulation amod [lemma='neurofibromin'] controllert,e1: args2Role-mention-ngram: which stimulatet$e1: args2Role-mention-ngram: Nf1 ) ,tAe1: trigger-arg-path: stimulate amod Gene_or_gene_productt%e1: ents2Label-mention-ngram: Nf1 ) ,t|e1: trigger-arg-path: Positive_regulation amod [lemma='neurofibromin'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: ( Nf1 )t!e1: ents2Label-mention-ngram: Nf1t-e2: ents2Label-mention-ngram: inactive SHAREDt+e2: ents2Label-mention-ngram: and formationt#e1: ents2Label-mention-ngram: Nf1 )tye1: trigger-arg-path: lemmatizedTrigger=stimulate amod [lemma='neurofibromin'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: hydrolysis andt"e1: args2Role-mention-ngram: Nf1 )t0e2: ents2Label-mention-ngram: of inactive SHAREDt`e1: trigger-arg-path: stimulate:Positive_regulation amod controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: hydrolysis and formationtKe1: trigger-arg-path: stimulate:Positive_regulation amod controllert/e1: ents2Label-mention-ngram: SHARED hydrolysistge1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED hydrolysis andt.e2: ents2Label-mention-ngram: and formation oftLe1: trigger-arg-path: stimulate amod controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: , which stimulatetre1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulate amod [lemma='neurofibromin'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: inactive SHAREDtvtrigger-to-trigger-path: e1:stimulate:Positive_regulation >dobj [lemma='hydrolysis'] e2:hydrolysis:Positive_regulationt+e1: ents2Label-mention-ngram: and formationt6e2: ents2Label-mention-ngram: hydrolysis and formationt3e2: ents2Label-mention-ngram: SHARED hydrolysis andtKe1: trigger-arg-path: Positive_regulation amod Gene_or_gene_productt e1: args2Role-mention-ngram: Nf1t,e2: ents2Label-mention-ngram: hydrolysis andt#e1: ents2Label-mention-ngram: ( Nf1t-e1: ents2Label-mention-ngram: which stimulatet?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod [lemma='neurofibromin'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=stimulate amod controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: ( Nf1t)e2: ents2Label-mention-ngram: of inactivet7e1: trigger-arg-path: stimulate amod controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation amod [lemma='neurofibromin'] controllertjshortest-path: rcmod [lemma='stimulate'] >dobj [lemma='hydrolysis'] >nn [lemma='gtp']tAe1: trigger-arg-path: Positive_regulation amod controllert8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( Nf1tUe1: trigger-arg-path: stimulate:Positive_regulation amod Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=stimulate amod [lemma='neurofibromin'] controllertatrigger-to-trigger-path: e1:stimulate:Positive_regulation >dobj e2:hydrolysis:Positive_regulationt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] themetRtrigger-to-trigger-path: e1:interaction:Binding ccomp e2:interacts:Bindingt_shortest-path: ccomp [lemma='interact'] >nsubj [lemma='pi3kc2beta-rbd']t interceding-token ngrams: raisestRe2: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta-rbd'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta-rbd'] themetTe2: trigger-arg-path: interacts >nsubj [lemma='pi3kc2beta-rbd'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta-rbd'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttPe2: trigger-arg-path: interacts >prep_with [lemma='rasgdp'] Gene_or_gene_producttce1: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt>e2: ents2Label-mention-ngram: with either GENE_OR_GENE_PRODUCTtde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] themetXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] themetue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta-rbd'] themet9e2: ents2Label-mention-ngram: either GENE_OR_GENE_PRODUCTt)interceding-token ngrams: the possibilityt3e2: ents2Label-mention-ngram: interacts with eithertEe2: trigger-arg-path: interacts >nsubj [lemma='pi3kc2beta-rbd'] themetke2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta-rbd'] theme:Gene_or_gene_producttXe2: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta-rbd'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rasgdp'] themet)e2: args2Role-mention-ngram: either THEMEtme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta-rbd'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_between [lemma='ras17n'] Gene_or_gene_productt0interceding-token ngrams: raises the possibilitytNe2: trigger-arg-path: Binding >prep_with [lemma='rasgdp'] Gene_or_gene_producttUe1: trigger-arg-path: interaction >prep_between [lemma='ras17n'] Gene_or_gene_productt.e2: args2Role-mention-ngram: with either THEMEtTe2: trigger-arg-path: Binding >prep_with [lemma='rasgdp'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3kc2beta-rbd'] themet?e2: trigger-arg-path: Binding >prep_with [lemma='rasgdp'] themetIe2: trigger-arg-path: interacts:Binding >prep_with [lemma='rasgdp'] themetBe1: trigger-arg-path: Binding >prep_between [lemma='ras17n'] themet^e2: trigger-arg-path: interacts:Binding >prep_with [lemma='rasgdp'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts >prep_with [lemma='rasgdp'] theme:Gene_or_gene_producttCe2: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta-rbd'] themetXe2: trigger-arg-path: interacts:Binding >prep_with [lemma='rasgdp'] Gene_or_gene_producttae1: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rasgdp'] theme:Gene_or_gene_productt$interceding-token ngrams: raises thet[e1: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] themet_e1: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] themetYe1: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttNe1: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] themet$e2: ents2Label-mention-ngram: eithert)e2: ents2Label-mention-ngram: with eithert[e1: trigger-arg-path: interaction >prep_between [lemma='ras17n'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta-rbd'] Gene_or_gene_productt.interceding-token ngrams: possibility that thetZe2: trigger-arg-path: interacts >nsubj [lemma='pi3kc2beta-rbd'] theme:Gene_or_gene_productt%interceding-token ngrams: possibilitytRe1: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] themetae2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rasgdp'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rasgdp'] theme:Gene_or_gene_producttAe2: trigger-arg-path: interacts >prep_with [lemma='rasgdp'] themet.interceding-token ngrams: the possibility thatt2e2: args2Role-mention-ngram: interacts with eithertie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rasgdp'] Gene_or_gene_producttFe1: trigger-arg-path: interaction >prep_between [lemma='ras17n'] themetge1: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttbe2: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3kc2beta-rbd'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: eithert(e2: args2Role-mention-ngram: with eithertge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] Gene_or_gene_producttWe1: trigger-arg-path: Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] Gene_or_gene_productt\e2: trigger-arg-path: interacts:Binding >nsubj [lemma='pi3kc2beta-rbd'] Gene_or_gene_producttJe1: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] themet*interceding-token ngrams: possibility thattke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttutrigger-to-trigger-path: e1:interaction:Binding ccomp [lemma='interact'] e2:interacts:Bindingt=interceding-tokens-full-span: raises the possibility that thetRe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rasgdp'] themetye1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_productt]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttpe2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] Gene_or_gene_productt[e2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] themetBe2: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt-e2: trigger-arg-path: Binding >prep_of FamilytZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] theme:Familythe2: trigger-arg-path: binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] Familytbe2: trigger-arg-path: Binding prep_to [lemma='raf1'] Gene_or_gene_producttHe2: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] theme:Familytze2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >prep_of [lemma='ra'] themetSe2: trigger-arg-path: binding prep_to [lemma='raf1'] themetee2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] themet9e2: trigger-arg-path: binding >prep_of [lemma='ra'] themetRe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] theme:Familytbe2: trigger-arg-path: binding prep_to [lemma='raf1'] Gene_or_gene_productt:e2: trigger-arg-path: binding >prep_of [lemma='ra'] Familytje2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt-e2: trigger-arg-path: binding >prep_of Familyt3e2: trigger-arg-path: binding >prep_of theme:FamilytGe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of Familythe2: trigger-arg-path: Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt;e2: trigger-arg-path: binding:Binding >prep_of theme:FamilytEe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of theme:Familyt5e2: trigger-arg-path: binding:Binding >prep_of Familyt@e2: trigger-arg-path: Binding >prep_of [lemma='ra'] theme:FamilytKe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of Familyt@e2: trigger-arg-path: binding >prep_of [lemma='ra'] theme:FamilytSe2: trigger-arg-path: Binding prep_to [lemma='raf1'] themetMe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of theme:FamilytTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] Familyt:e2: trigger-arg-path: Binding >prep_of [lemma='ra'] FamilytSe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] themet3e2: trigger-arg-path: Binding >prep_of theme:FamilytAe2: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] themetme2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] themetMe1: trigger-arg-path: activation >prep_of [lemma='AMPK'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='growth'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='growth'] Gene_or_gene_productt?shortest-path: nsubjpass [lemma='repression'] >prep_of [lemma='signaling'] >prep_through [lemma='AMPK']tRe2: trigger-arg-path: complex:Binding >nn [lemma='TSC'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='TSC'] theme:Gene_or_gene_productt^e1: trigger-arg-path: activation:Positive_activation >nn [lemma='growth'] Gene_or_gene_productt+interceding-token ngrams: signaling throughtYe2: trigger-arg-path: complex:Binding nn [lemma='TSC'] Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='TSC'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='growth'] controllert=e2: trigger-arg-path: complex:Binding >nn [lemma='TSC'] themetje1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='AMPK'] controlled:Gene_or_gene_producttae1: trigger-arg-path: Positive_activation >prep_of [lemma='AMPK'] controlled:Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated activationtOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='TSC'] themetSe1: trigger-arg-path: Positive_activation >nn [lemma='growth'] Gene_or_gene_producttle1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='AMPK'] controlled:Gene_or_gene_producttCe1: trigger-arg-path: activation >prep_of [lemma='AMPK'] controlledt?trigger-to-trigger-path: e1:activation:Positive_activation nsubjpass [lemma='repression'] >prep_of [lemma='signaling'] >prep_through [lemma='complex'] e2:complex:Bindingt0interceding-token ngrams: mTOR signaling throughtVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='TSC'] Gene_or_gene_producttIshortest-path: nsubjpass >prep_of >prep_throughtVe1: trigger-arg-path: Positive_activation >prep_of [lemma='AMPK'] Gene_or_gene_productt#interceding-token ngrams: signalingt^e1: trigger-arg-path: Positive_activation >nn [lemma='growth'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='TSC'] Gene_or_gene_productt)interceding-token ngrams: , repression oftQe2: trigger-arg-path: Binding nn [lemma='growth'] controller:Gene_or_gene_producttae1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='AMPK'] Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='TSC'] themetnn [lemma='TSC'] themetUe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='AMPK'] controlledt&interceding-token ngrams: , repressiontJe1: trigger-arg-path: activation >nn [lemma='growth'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_of [lemma='AMPK'] controlledtRe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='growth'] controllertXe1: trigger-arg-path: activation >prep_of [lemma='AMPK'] controlled:Gene_or_gene_productt?trigger-to-trigger-path: e1:activation:Positive_activation nsubjpass >prep_of >prep_through e2:complex:BindingtDe2: trigger-arg-path: complex:Binding nn [lemma='TSC'] themetce2: trigger-arg-path: lemmatizedTrigger=complex prep_of [lemma='AMPK'] Gene_or_gene_productt;e1: args2Role-mention-ngram: CONTROLLER mediated activationtnn [lemma='growth'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='growth'] controllertNe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='growth'] controllert%interceding-token ngrams: through thet$interceding-token ngrams: repressiontDe2: trigger-arg-path: complex >nn [lemma='TSC'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='TSC'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='TSC'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='AMPK'] Gene_or_gene_productt/interceding-token ngrams: signaling through thetJe2: trigger-arg-path: Binding >nn [lemma='TSC'] theme:Gene_or_gene_producttHinterceding-tokens-full-span: , repression of mTOR signaling through thetLe1: trigger-arg-path: Positive_activation >prep_of [lemma='AMPK'] controlledtie1: trigger-arg-path: activation:Positive_activation >nn [lemma='growth'] controller:Gene_or_gene_productt'interceding-token ngrams: repression oft~e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='AMPK'] controlled:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='growth'] controller:Gene_or_gene_producttKe2: trigger-arg-path: Binding prep_of [lemma='AMPK'] controlledt,interceding-token ngrams: repression of mTORtIe1: trigger-arg-path: Positive_activation >nn [lemma='growth'] controllertKe2: trigger-arg-path: prevents prep_with [lemma='ampk'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=prevent >prep_with [lemma='ampk'] controllert5e2: args2Role-mention-ngram: prevents its interactiontae2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation conj_and [lemma='prevent'] e2:prevents:Negative_regulationtQe1: trigger-arg-path: phosphorylates >nsubj [lemma='mtorc1'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >prep_with controllertle1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mtorc1'] controllertpe2: trigger-arg-path: lemmatizedTrigger=prevent prep_with [lemma='ampk'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=prevent prep_with [lemma='ampk'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mtorc1'] controllertnsubj [lemma='mtorc1'] controllertie2: trigger-arg-path: lemmatizedTrigger=prevent >prep_with [lemma='ampk'] controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: prevents itstHe2: trigger-arg-path: prevents:Negative_regulation >prep_with controllerthtrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and e2:prevents:Negative_regulationt3e2: trigger-arg-path: prevents prep_with controller:Gene_or_gene_productt[e2: trigger-arg-path: prevents:Negative_regulation nsubj [lemma='mtorc1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation e2: trigger-arg-path: prevents >prep_with Gene_or_gene_productthe2: trigger-arg-path: prevents:Negative_regulation prep_with [lemma='ampk'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation prep_with [lemma='ampk'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj [lemma='mtorc1'] Gene_or_gene_productt%e2: args2Role-mention-ngram: preventstTe2: trigger-arg-path: Negative_regulation >prep_with controller:Gene_or_gene_producttRe2: trigger-arg-path: prevents:Negative_regulation >prep_with Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtorc1'] controller:Gene_or_gene_producttMe2: trigger-arg-path: prevents >prep_with [lemma='ampk'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: phosphorylates SHARED andtce2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >prep_with Gene_or_gene_producttWe2: trigger-arg-path: prevents:Negative_regulation >prep_with [lemma='ampk'] controllertXe2: trigger-arg-path: Negative_regulation >prep_with [lemma='ampk'] Gene_or_gene_producttpe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtorc1'] controller:Gene_or_gene_producttCe2: ents2Label-mention-ngram: interaction with GENE_OR_GENE_PRODUCTt1e2: args2Role-mention-ngram: and thereby preventst_e2: trigger-arg-path: prevents:Negative_regulation nsubj [lemma='mtorc1'] controller:Gene_or_gene_productt4e2: trigger-arg-path: prevents >prep_with controllert&e2: ents2Label-mention-ngram: preventstNe2: trigger-arg-path: Negative_regulation >prep_with [lemma='ampk'] controllert-e2: args2Role-mention-ngram: thereby preventst[e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtorc1'] controllertPe2: trigger-arg-path: prevents:Negative_regulation prep_with controller:Gene_or_gene_producttIe2: trigger-arg-path: Negative_regulation >prep_with Gene_or_gene_productt\e1: trigger-arg-path: phosphorylates >nsubj [lemma='mtorc1'] controller:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=prevent prep_with [lemma='ampk'] controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLED and therebytEe2: trigger-arg-path: lemmatizedTrigger=prevent >prep_with controllert*e2: ents2Label-mention-ngram: prevents itstCe2: trigger-arg-path: prevents >prep_with [lemma='ampk'] controllertve1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mtorc1'] Gene_or_gene_producttTe2: trigger-arg-path: prevents prep_with Gene_or_gene_productt2e2: ents2Label-mention-ngram: and thereby preventstGe1: trigger-arg-path: phosphorylates >nsubj [lemma='mtorc1'] controllert]e2: trigger-arg-path: prevents:Negative_regulation >prep_with controller:Gene_or_gene_producttee1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtorc1'] Gene_or_gene_producttXe2: trigger-arg-path: prevents >prep_with [lemma='ampk'] controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >prep_with [lemma='ampk'] controllert1e2: args2Role-mention-ngram: thereby prevents itst6e2: ents2Label-mention-ngram: prevents its interactiont?e2: trigger-arg-path: Negative_regulation >prep_with controllertIe2: trigger-arg-path: prevents >prep_with controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mtorc1'] controller:Gene_or_gene_productt(e2: args2Role-mention-ngram: PAK , whichtSe2: trigger-arg-path: interacts >prep_with [lemma='pix'] theme:Gene_or_gene_productt[trigger-to-trigger-path: e1:binds:Binding >conj_but [lemma='interact'] e2:interacts:Bindingtfe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] Gene_or_gene_productt-e2: args2Role-mention-ngram: Rac effector butt/e2: args2Role-mention-ngram: but also interactst e2: args2Role-mention-ngram: PAKt(e2: args2Role-mention-ngram: is not onlytprep_with [lemma='pix'] themet)e2: args2Role-mention-ngram: which is nottMe2: trigger-arg-path: interacts >prep_with [lemma='pix'] Gene_or_gene_productt"e2: args2Role-mention-ngram: PAK ,t>e2: trigger-arg-path: interacts >prep_with [lemma='pix'] themetle2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: a Rac effectort#e2: args2Role-mention-ngram: only atFe2: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] themetde2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: also interactst[e2: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: but alsotOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] themet#e2: args2Role-mention-ngram: is nott.e2: args2Role-mention-ngram: effector but alsot)e2: args2Role-mention-ngram: effector butt(e2: args2Role-mention-ngram: binds PAK ,t%e2: args2Role-mention-ngram: effectortKe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] themetBe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] themetHtrigger-to-trigger-path: e1:binds:Binding >conj_but e2:interacts:Bindingt,e2: args2Role-mention-ngram: THEME binds PAKtZe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] Gene_or_gene_producttQe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] Gene_or_gene_productt e2: args2Role-mention-ngram: Ract'e2: args2Role-mention-ngram: not only at'e2: args2Role-mention-ngram: only a Ract:e2: trigger-arg-path: interacts >nsubj [lemma='rac'] themet`e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: Rac effectortWe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_producttUe2: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] Gene_or_gene_productt"e2: args2Role-mention-ngram: a Ractbe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] Gene_or_gene_productt&e2: args2Role-mention-ngram: binds PAKtQe2: trigger-arg-path: Binding >prep_with [lemma='pix'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] themetIe2: trigger-arg-path: interacts >nsubj [lemma='rac'] Gene_or_gene_producttOe2: trigger-arg-path: interacts >nsubj [lemma='rac'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: also interacts withtWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] themetKe2: trigger-arg-path: Binding >prep_with [lemma='pix'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] Gene_or_gene_productt3e2: args2Role-mention-ngram: and repress CONTROLLEDtRe1: trigger-arg-path: interact:Binding >nsubj [lemma='smad4'] Gene_or_gene_productt0e1: args2Role-mention-ngram: together with SMAD3t\e2: trigger-arg-path: Negative_activation >dobj [lemma='ar'] controlled:Gene_or_gene_productt*e1: args2Role-mention-ngram: together withtMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smad4'] themet0e2: ents2Label-mention-ngram: SHARED and represstWe2: trigger-arg-path: repress:Negative_activation >dobj controlled:Gene_or_gene_productt(e1: ents2Label-mention-ngram: , togethertMe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='ar'] controlledt/e2: ents2Label-mention-ngram: SHARED , togethert$e2: args2Role-mention-ngram: represst,e1: ents2Label-mention-ngram: SMAD3 can alsot-e1: ents2Label-mention-ngram: , together witht;e2: trigger-arg-path: repress >dobj [lemma='ar'] controlledtNe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ar'] themetOe1: trigger-arg-path: Binding >nsubj [lemma='smad4'] theme:Gene_or_gene_productte2: trigger: represstCe1: trigger-arg-path: interact:Binding >nsubj [lemma='smad4'] themetUtrigger-to-trigger-path: e1:interact:Binding >conj_and e2:repress:Negative_activationt%e1: args2Role-mention-ngram: can alsot:e1: trigger-arg-path: Binding >nsubj [lemma='smad4'] themet'e1: args2Role-mention-ngram: , togethert-e1: args2Role-mention-ngram: THEME , togethert+e2: ents2Label-mention-ngram: together witht\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smad4'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: with SMAD3t,e1: ents2Label-mention-ngram: with SMAD3 cantve2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='ar'] controlled:Gene_or_gene_productt;e1: trigger-arg-path: interact >nsubj [lemma='smad4'] themet&e1: ents2Label-mention-ngram: can alsotCe2: trigger-arg-path: repress >dobj controlled:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smad4'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: also interacttprep_with [lemma='ar'] themet,e2: ents2Label-mention-ngram: with SMAD3 cant]e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ar'] Gene_or_gene_producttYe1: trigger-arg-path: interact:Binding >prep_with [lemma='ar'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: can also interacttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smad4'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ar'] themet.e2: trigger-arg-path: repress >dobj controlledt,e2: ents2Label-mention-ngram: SMAD3 can alsotce1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ar'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='ar'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ar'] Gene_or_gene_producttSe1: trigger-arg-path: interact:Binding >prep_with [lemma='ar'] Gene_or_gene_producttLe2: trigger-arg-path: repress:Negative_activation >dobj Gene_or_gene_producttPe1: trigger-arg-path: interact >nsubj [lemma='smad4'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: with SMAD3t'e2: ents2Label-mention-ngram: SMAD3 cant"e1: args2Role-mention-ngram: SMAD3t+e1: ents2Label-mention-ngram: together withtPe2: trigger-arg-path: repress >dobj [lemma='ar'] controlled:Gene_or_gene_productt#e1: ents2Label-mention-ngram: SMAD3tPe1: trigger-arg-path: Binding >prep_with [lemma='ar'] theme:Gene_or_gene_productt8e2: trigger-arg-path: repress >dobj Gene_or_gene_productt,e2: ents2Label-mention-ngram: repress SHAREDtUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smad4'] themet'e1: args2Role-mention-ngram: with SMAD3t,e1: args2Role-mention-ngram: , together witht+e1: args2Role-mention-ngram: with SMAD3 cant)e2: ents2Label-mention-ngram: and represst3e2: args2Role-mention-ngram: CONTROLLER and represst;e1: trigger-arg-path: Binding >prep_with [lemma='ar'] themet1e1: ents2Label-mention-ngram: together with SMAD3t/e1: args2Role-mention-ngram: also interact witht0e2: ents2Label-mention-ngram: and repress SHAREDtBe2: trigger-arg-path: repress:Negative_activation >dobj controlledt+e1: args2Role-mention-ngram: SMAD3 can alsot&e1: args2Role-mention-ngram: SMAD3 cant*e1: args2Role-mention-ngram: also interacttKe1: trigger-arg-path: interact >prep_with [lemma='ar'] Gene_or_gene_producttJe1: trigger-arg-path: interact >nsubj [lemma='smad4'] Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='smad4'] Gene_or_gene_producttQe2: trigger-arg-path: Negative_activation >dobj [lemma='ar'] Gene_or_gene_producttDe1: trigger-arg-path: interact:Binding >prep_with [lemma='ar'] themetXe1: trigger-arg-path: interact:Binding >nsubj [lemma='smad4'] theme:Gene_or_gene_producttOe2: trigger-arg-path: repress:Negative_activation >dobj [lemma='ar'] controlledt/e1: ents2Label-mention-ngram: can also interactt-e2: ents2Label-mention-ngram: , together witht/e1: ents2Label-mention-ngram: SHARED , togethert(e2: ents2Label-mention-ngram: , togethert%e1: args2Role-mention-ngram: togethertae2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >dobj [lemma='ar'] controlledt#e2: ents2Label-mention-ngram: SMAD3tgtrigger-to-trigger-path: e1:interact:Binding >conj_and [lemma='repress'] e2:repress:Negative_activationtbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smad4'] theme:Gene_or_gene_producttQe1: trigger-arg-path: interact >prep_with [lemma='ar'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: togethert&e2: ents2Label-mention-ngram: togethert'e1: ents2Label-mention-ngram: SMAD3 cantEe2: trigger-arg-path: repress >dobj [lemma='ar'] Gene_or_gene_producttGe2: trigger-arg-path: Negative_activation >dobj [lemma='ar'] controlledt/e2: args2Role-mention-ngram: repress CONTROLLEDtbe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='ar'] controlled:Gene_or_gene_producttYe2: trigger-arg-path: repress:Negative_activation >dobj [lemma='ar'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=repress >dobj [lemma='ar'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: also interact withtke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ar'] theme:Gene_or_gene_producttde2: trigger-arg-path: repress:Negative_activation >dobj [lemma='ar'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_with [lemma='ar'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: represst1e2: ents2Label-mention-ngram: together with SMAD3t(e2: args2Role-mention-ngram: and represstie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ulk1'] controllert"shortest-path: prep_to >nntQe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='this'] Generic_entityt*e1: args2Role-mention-ngram: leads to ULK1tle2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ulk1'] controller:Gene_or_gene_producttnsubj [lemma='this'] controllertPe1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='this'] controllertae1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj controller:Generic_entitytAe1: trigger-arg-path: leads:Positive_regulation >nsubj controllert%e1: ents2Label-mention-ngram: to ULK1t#e1: ents2Label-mention-ngram: leadstpe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='this'] controller:Generic_entityt-e1: args2Role-mention-ngram: CONTROLLER leadst\e1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='this'] controller:Generic_entitytXe2: trigger-arg-path: phosphorylation >nn [lemma='ulk1'] controller:Gene_or_gene_productt1e1: trigger-arg-path: leads >nsubj Generic_entitytKe1: trigger-arg-path: leads >nsubj [lemma='this'] controller:Generic_entitytnsubj controller:Generic_entitytRe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj controllertPe1: trigger-arg-path: leads:Positive_regulation >nsubj controller:Generic_entityt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ulk1'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ulk1'] Gene_or_gene_producttQe2: trigger-arg-path: Positive_regulation >nn [lemma='ulk1'] Gene_or_gene_productt/e1: args2Role-mention-ngram: to ULK1 CONTROLLEDtTe1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='this'] Generic_entitytae2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ulk1'] Gene_or_gene_producttetrigger-to-trigger-path: e1:leads:Positive_regulation >prep_to e2:phosphorylation:Positive_regulationt,e1: args2Role-mention-ngram: ULK1 CONTROLLEDt\e2: trigger-arg-path: Positive_regulation >nn [lemma='ulk1'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='this'] Generic_entitytMe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='this'] controllert5e1: ents2Label-mention-ngram: ULK1 phosphorylation oftVe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj Generic_entitytje2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ulk1'] controller:Gene_or_gene_productte1: trigger: leadst>e1: trigger-arg-path: lemmatizedTrigger=lead >nsubj controllert+e1: ents2Label-mention-ngram: leads to ULK1tCe2: trigger-arg-path: phosphorylation >nn [lemma='ulk1'] controllert!e1: args2Role-mention-ngram: ULK1tUe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ulk1'] controllertMe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj controller:Generic_entityttrigger-to-trigger-path: e1:leads:Positive_regulation >prep_to [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtWe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ulk1'] controllert2e1: ents2Label-mention-ngram: ULK1 phosphorylationt-e1: trigger-arg-path: leads >nsubj controllert5e1: ents2Label-mention-ngram: to ULK1 phosphorylationt5e1: ents2Label-mention-ngram: GENERIC_ENTITY leads tot0e1: args2Role-mention-ngram: CONTROLLER leads totGe2: trigger-arg-path: Positive_regulation >nn [lemma='ulk1'] controllertZshortest-path: prep_to [lemma='phosphorylation'] >nn [lemma='ulk1']tEe1: trigger-arg-path: leads:Positive_regulation >nsubj Generic_entitytBe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj Generic_entityt2e1: ents2Label-mention-ngram: GENERIC_ENTITY leadst%e1: args2Role-mention-ngram: leads totae1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='this'] controllertMe2: trigger-arg-path: phosphorylation >nn [lemma='ulk1'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: leads tot_e1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='this'] controller:Generic_entityt@e1: trigger-arg-path: leads >nsubj [lemma='this'] Generic_entityt"e1: args2Role-mention-ngram: leadst~e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ulk1'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: to ULK1tEe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylation oft"e1: ents2Label-mention-ngram: ULK1tRe1: trigger-arg-path: Binding:Binding >prep_of >prep_to theme:Gene_or_gene_producttse1: trigger-arg-path: Binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: Bindingt-e1: args2Role-mention-ngram: Binding of THEMEtle2: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlled:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] theme:Gene_or_gene_productt7e1: args2Role-mention-ngram: transcription factor THEMEt5e1: args2Role-mention-ngram: the transcription factort2e2: ents2Label-mention-ngram: transcription factortOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to themet\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to themet+e1: ents2Label-mention-ngram: factor SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlled:Gene_or_gene_productt4e2: trigger-arg-path: increases >dobj >nn controlledt(e1: ents2Label-mention-ngram: Binding oftVe1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] themet6e2: ents2Label-mention-ngram: the transcription factortve2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlled:Gene_or_gene_productt%e1: ents2Label-mention-ngram: Bindingt'e1: args2Role-mention-ngram: Binding oftRe2: trigger-arg-path: increases:Positive_activation >dobj >nn Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] themetke2: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlledt^e1: trigger-arg-path: Binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] themet2e2: ents2Label-mention-ngram: to the transcriptiontae2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlledtfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] Gene_or_gene_productt>e2: trigger-arg-path: increases >dobj >nn Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] themet2e1: ents2Label-mention-ngram: transcription factortDe1: trigger-arg-path: Binding >prep_of >prep_to Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: Binding of SHAREDt/e2: ents2Label-mention-ngram: the transcriptiont]e2: trigger-arg-path: increases:Positive_activation >dobj >nn controlled:Gene_or_gene_producttHe2: trigger-arg-path: increases:Positive_activation >dobj >nn controlledtRe1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] theme:Gene_or_gene_productte1: trigger: BindingtLe1: trigger-arg-path: Binding:Binding >prep_of >prep_to Gene_or_gene_producttCe1: trigger-arg-path: Binding:Binding >prep_of Gene_or_gene_productt.e1: args2Role-mention-ngram: the transcriptiont?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] theme:Gene_or_gene_productt4e1: trigger-arg-path: Binding:Binding >prep_of themet9e1: ents2Label-mention-ngram: transcription factor SHAREDtZe1: trigger-arg-path: Binding:Binding >prep_of [lemma='parp-1'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] Gene_or_gene_producttftrigger-to-trigger-path: e1:Binding:Binding dobj [lemma='activity'] >nn [lemma='e2f-1'] controlledtZe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlled:Gene_or_gene_productt?e2: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlled:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlled:Gene_or_gene_producttue2: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: to the transcriptiontde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to theme:Gene_or_gene_producttIe2: trigger-arg-path: increases >dobj >nn controlled:Gene_or_gene_producttWe2: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlledtne2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlled:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] themet)e1: args2Role-mention-ngram: THEME to thetWe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='parp-1'] themetOe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] themetre2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='e2f-1'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: factor SHARED increasestwe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: transcription factort)e1: args2Role-mention-ngram: factor THEMEt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to Gene_or_gene_productt9e2: ents2Label-mention-ngram: transcription factor SHAREDt=e1: trigger-arg-path: Binding:Binding >prep_of >prep_to themet^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] Gene_or_gene_productt5e1: trigger-arg-path: Binding >prep_of >prep_to themet+e2: ents2Label-mention-ngram: factor SHAREDtIe1: trigger-arg-path: Binding:Binding >prep_of theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: to the transcriptiontOe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn Gene_or_gene_producttTe1: trigger-arg-path: Binding:Binding >prep_of [lemma='parp-1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn Gene_or_gene_producttme1: trigger-arg-path: Binding:Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] Gene_or_gene_producttke2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='e2f-1'] controlledtke1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] theme:Gene_or_gene_productt5e2: ents2Label-mention-ngram: SHARED increases SHAREDt}e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: the transcriptiontStrigger-to-trigger-path: e1:Binding:Binding prep_of [lemma='parp-1'] themetJe1: trigger-arg-path: Binding >prep_of >prep_to theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: increases SHAREDtee1: trigger-arg-path: Binding >prep_of [lemma='parp-1'] >prep_to [lemma='e2f-1'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: the transcription factortae2: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='e2f-1'] Gene_or_gene_productt-e1: args2Role-mention-ngram: GCK-1 also bindsthe1: trigger-arg-path: binds:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] Gene_or_gene_producttLe2: trigger-arg-path: inhibits:Negative_regulation advmod ComplextYe1: trigger-arg-path: binds:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] themetbe1: trigger-arg-path: Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] Gene_or_gene_producttWe2: trigger-arg-path: inhibits:Negative_regulation advmod controller:Complextne1: trigger-arg-path: binds:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] theme:Gene_or_gene_producttde2: trigger-arg-path: Negative_regulation advmod [lemma='also'] controllertNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >amod Gene_or_gene_productt"e1: args2Role-mention-ngram: GCK-1tje2: trigger-arg-path: lemmatizedTrigger=inhibit advmod [lemma='also'] controllertshortest-path: nntYe2: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] PhosphorylationtEe1: trigger-arg-path: binds:Binding >nsubj >amod Gene_or_gene_producttue2: trigger-arg-path: inhibits:Negative_regulation advmod [lemma='also'] controller:Complext{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod [lemma='also'] Complext]e2: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] controlledtFe2: trigger-arg-path: Negative_regulation advmod controllert(e2: ents2Label-mention-ngram: also bindst=e1: trigger-arg-path: binds >nsubj >amod Gene_or_gene_productt.e1: trigger-arg-path: binds >nsubj >amod themetCe2: trigger-arg-path: Negative_regulation advmod Complextse2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationtye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mpk-1'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >amod theme:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod [lemma='also'] controllert#e1: ents2Label-mention-ngram: GCK-1tIe1: trigger-arg-path: binds >prep_to [lemma='mpk-1'] Gene_or_gene_producttWe1: trigger-arg-path: binds:Binding >prep_to [lemma='mpk-1'] theme:Gene_or_gene_productt`e1: trigger-arg-path: binds >nsubj [lemma='gck-1'] >amod [lemma='germinal'] Gene_or_gene_producttCe2: trigger-arg-path: inhibits advmod controller:Complexthe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod controller:Complext:e1: trigger-arg-path: binds >prep_to [lemma='mpk-1'] themetwe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gck-1'] >amod [lemma='germinal'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlled:Phosphorylationt#e2: ents2Label-mention-ngram: GCK-1tae2: trigger-arg-path: inhibits advmod [lemma='also'] controller:ComplextVe2: trigger-arg-path: inhibits advmod [lemma='also'] ComplextTe2: trigger-arg-path: lemmatizedTrigger=inhibit advmod controller:ComplextQe1: trigger-arg-path: binds:Binding >prep_to [lemma='mpk-1'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: GCK-1 also bindst?e1: trigger-arg-path: Binding >nsubj >amod Gene_or_gene_producttOe1: trigger-arg-path: binds >prep_to [lemma='mpk-1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: binds >nsubj [lemma='gck-1'] >amod [lemma='germinal'] themet8e2: trigger-arg-path: inhibits advmod Complext(e1: args2Role-mention-ngram: THEME GCK-1t/e1: ents2Label-mention-ngram: SHARED GCK-1 alsot(e2: ents2Label-mention-ngram: GCK-1 alsotGe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >amod themethe1: trigger-arg-path: Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gck-1'] >amod [lemma='germinal'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=inhibit advmod [lemma='also'] controller:Complextme2: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt1e1: ents2Label-mention-ngram: also binds directlytKe1: trigger-arg-path: Binding >prep_to [lemma='mpk-1'] Gene_or_gene_producttprep_to [lemma='mpk-1'] themetNe2: trigger-arg-path: Negative_regulation advmod controller:ComplextCe1: trigger-arg-path: binds >nsubj >amod theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >amod themetEe1: trigger-arg-path: Binding >nsubj >amod theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED GCK-1tbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mpk-1'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gck-1'] >amod [lemma='germinal'] themetYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj Phosphorylationtle2: trigger-arg-path: Negative_regulation advmod [lemma='also'] controller:ComplextSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mpk-1'] themetOe2: trigger-arg-path: inhibits:Negative_regulation advmod controllertLe2: trigger-arg-path: lemmatizedTrigger=inhibit advmod controllert(e1: ents2Label-mention-ngram: GCK-1 alsote1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod ComplextSe2: trigger-arg-path: inhibits:Negative_regulation >dobj controlled:PhosphorylationtHe2: trigger-arg-path: inhibits:Negative_regulation >dobj PhosphorylationtKe1: trigger-arg-path: binds:Binding >nsubj >amod theme:Gene_or_gene_productt6e1: trigger-arg-path: binds:Binding >nsubj >amod themet1e2: ents2Label-mention-ngram: also binds directlyt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod [lemma='also'] controller:Complextde2: trigger-arg-path: Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtje2: trigger-arg-path: inhibits:Negative_regulation advmod [lemma='also'] Complextbe2: trigger-arg-path: inhibits:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt0e1: trigger-arg-path: Binding >nsubj >amod themet'e1: args2Role-mention-ngram: GCK-1 alsot*e2: ents2Label-mention-ngram: SHARED GCK-1tKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mpk-1'] themethe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mpk-1'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: also binds directlytYe2: trigger-arg-path: inhibits advmod [lemma='also'] controllert.e1: ents2Label-mention-ngram: GCK-1 also bindst-e1: args2Role-mention-ngram: THEME GCK-1 alsotTe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >amod theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_to [lemma='mpk-1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation advmod controllertfe1: trigger-arg-path: binds >nsubj [lemma='gck-1'] >amod [lemma='germinal'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] themetme2: trigger-arg-path: inhibits:Negative_regulation advmod [lemma='also'] controllert~e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt/e2: ents2Label-mention-ngram: SHARED GCK-1 alsotIe2: trigger-arg-path: lemmatizedTrigger=inhibit advmod ComplextSe1: trigger-arg-path: Binding >nsubj [lemma='gck-1'] >amod [lemma='germinal'] themet9shortest-path: nn [lemma='Center']tZe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mpk-1'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >amod Gene_or_gene_producttBe1: trigger-arg-path: binds:Binding >prep_to [lemma='mpk-1'] themet;e2: trigger-arg-path: inhibits advmod controllertge2: trigger-arg-path: lemmatizedTrigger=inhibit advmod [lemma='also'] Complextne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlledtae2: trigger-arg-path: Negative_regulation advmod [lemma='also'] Complext[e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='relb'] Gene_or_gene_producttFe1: trigger-arg-path: bound >nsubj >prep_of theme:Gene_or_gene_producttCe2: trigger-arg-path: heterodimers:Binding >nn [lemma='relb'] themetwtrigger-to-trigger-path: e1:bound:Binding >xcomp [lemma='generate'] >dobj [lemma='heterodimer'] e2:heterodimers:Bindingt:e2: trigger-arg-path: heterodimers >nn [lemma='p52'] themetNe1: trigger-arg-path: bound >prep_to [lemma='relb'] theme:Gene_or_gene_producttWe2: trigger-arg-path: heterodimers:Binding >nn [lemma='p52'] theme:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='processing'] >prep_of [lemma='p100'] Gene_or_gene_producttHe1: trigger-arg-path: bound:Binding >nsubj >prep_of Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound totLe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='relb'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='relb'] themet`e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='p52'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] themetVe1: trigger-arg-path: bound:Binding >prep_to [lemma='relb'] theme:Gene_or_gene_producttle1: trigger-arg-path: bound:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] Gene_or_gene_producttBe2: trigger-arg-path: heterodimers:Binding >nn [lemma='p52'] themetre1: trigger-arg-path: bound:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] theme:Gene_or_gene_producttPe2: trigger-arg-path: heterodimers >nn [lemma='relb'] theme:Gene_or_gene_producttQe2: trigger-arg-path: heterodimers:Binding >nn [lemma='p52'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='relb'] theme:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='processing'] >prep_of [lemma='p100'] theme:Gene_or_gene_producttWe1: trigger-arg-path: Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] themet/e2: args2Role-mention-ngram: THEME heterodimerstae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='relb'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='p52'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME bound tot1e2: ents2Label-mention-ngram: SHARED heterodimerst5e2: trigger-arg-path: Binding >nn [lemma='p52'] themet&interceding-token ngrams: , generatingt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] theme:Gene_or_gene_producttje1: trigger-arg-path: bound >nsubj [lemma='processing'] >prep_of [lemma='p100'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='p52'] themetJe1: trigger-arg-path: Binding >prep_to [lemma='relb'] Gene_or_gene_productt3e2: args2Role-mention-ngram: and THEME heterodimerst_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='relb'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='relb'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='p52'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='relb'] theme:Gene_or_gene_productt?shortest-path: xcomp [lemma='generate'] >dobj [lemma='heterodimer'] >nn [lemma='p52']tNe1: trigger-arg-path: bound:Binding >nsubj >prep_of theme:Gene_or_gene_producttle1: trigger-arg-path: Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='relb'] Gene_or_gene_producttIe2: trigger-arg-path: heterodimers >nn [lemma='p52'] Gene_or_gene_producttfe1: trigger-arg-path: Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: heterodimerstAe2: trigger-arg-path: heterodimers >nn theme:Gene_or_gene_producttIe2: trigger-arg-path: heterodimers:Binding >nn theme:Gene_or_gene_productt*interceding-tokens-full-span: , generatingtPe1: trigger-arg-path: bound:Binding >prep_to [lemma='relb'] Gene_or_gene_producttde1: trigger-arg-path: bound >nsubj [lemma='processing'] >prep_of [lemma='p100'] Gene_or_gene_producttHe1: trigger-arg-path: bound >prep_to [lemma='relb'] Gene_or_gene_producttUe1: trigger-arg-path: bound >nsubj [lemma='processing'] >prep_of [lemma='p100'] themete2: trigger: heterodimerstSe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='p52'] themetDe2: trigger-arg-path: Binding >nn [lemma='p52'] Gene_or_gene_producttXe2: trigger-arg-path: heterodimers:Binding >nn [lemma='relb'] theme:Gene_or_gene_producttRe2: trigger-arg-path: heterodimers:Binding >nn [lemma='relb'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: and SHARED heterodimerstbe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='p52'] Gene_or_gene_producttNtrigger-to-trigger-path: e1:bound:Binding >xcomp >dobj e2:heterodimers:Bindingt]e1: trigger-arg-path: bound:Binding >nsubj [lemma='processing'] >prep_of [lemma='p100'] themet;e2: trigger-arg-path: heterodimers >nn Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='relb'] themethe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='p52'] theme:Gene_or_gene_productt@e1: trigger-arg-path: bound >nsubj >prep_of Gene_or_gene_productt$interceding-token ngrams: generatingtOe2: trigger-arg-path: heterodimers >nn [lemma='p52'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: heterodimerstfe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='processing'] >prep_of [lemma='p100'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='relb'] themetCe2: trigger-arg-path: heterodimers:Binding >nn Gene_or_gene_productt4e2: trigger-arg-path: heterodimers:Binding >nn themetAe1: trigger-arg-path: bound:Binding >prep_to [lemma='relb'] themet,e2: trigger-arg-path: heterodimers >nn themetTe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='relb'] themet/shortest-path: xcomp >dobj >nntae2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='relb'] theme:Gene_or_gene_productt;e2: trigger-arg-path: heterodimers >nn [lemma='relb'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='relb'] theme:Gene_or_gene_productt9e1: trigger-arg-path: bound >prep_to [lemma='relb'] themetJe2: trigger-arg-path: heterodimers >nn [lemma='relb'] Gene_or_gene_producttFe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL promotes phosphorylationtje1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltge1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] controller:Simple_chemicalt&e1: ents2Label-mention-ngram: Chk1 andt_e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicaltke1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj Simple_chemicaltFe1: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] controllertQe1: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] controllert%e1: ents2Label-mention-ngram: by Chk1tZe1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='doxorubicin'] controllert?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controllert?e2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: promotes phosphorylation oft?e2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controller:Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicalt;e1: args2Role-mention-ngram: CONTROLLER promotes CONTROLLEDtetrigger-to-trigger-path: e1:promotes:Positive_regulation >dobj e2:phosphorylation:Positive_regulationtue2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] controllert6e1: ents2Label-mention-ngram: promotes phosphorylationt;e1: ents2Label-mention-ngram: Chk1 and GENE_OR_GENE_PRODUCTt\e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] Simple_chemicaltKe1: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] controller:Gene_or_gene_productttrigger-to-trigger-path: e1:promotes:Positive_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationt6e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL promotest5e1: trigger-arg-path: promotes >nsubj Simple_chemicaltTe1: trigger-arg-path: promotes:Positive_regulation >nsubj controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controllert{e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] controller:Simple_chemicaltZe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj Simple_chemicaltVe1: trigger-arg-path: promotes >nsubj [lemma='doxorubicin'] controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] controllertye2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controllert,e1: ents2Label-mention-ngram: SHARED by Chk1t@e1: trigger-arg-path: promotes >nsubj controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] Gene_or_gene_producttGshortest-path: dobj [lemma='phosphorylation']tee1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controller:Simple_chemicaltQe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: by Chk1 andt"e1: ents2Label-mention-ngram: Chk1tVe1: trigger-arg-path: Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicalt?e2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] controller:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='doxorubicin'] controllerte2: trigger-arg-path: phosphorylation prep_by [lemma='kinase'] >nn [lemma='chk1'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='doxorubicin'] Simple_chemicalt?e2: trigger-arg-path: Positive_regulation prep_by [lemma='kinase'] >nn [lemma='chk1'] Gene_or_gene_producttIe1: trigger-arg-path: promotes:Positive_regulation >nsubj Simple_chemicaltce2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='brca1'] Complextie2: trigger-arg-path: promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlledtIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] themethe2: trigger-arg-path: promote:Positive_activation nsubj [lemma='brca1'] controllert[e2: trigger-arg-path: promote:Positive_activation >dobj >nn controlled:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] themet-e2: ents2Label-mention-ngram: SHARED can bindtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='stat3'] theme:Gene_or_gene_producttGe2: trigger-arg-path: promote >dobj >nn controlled:Gene_or_gene_productt>e1: trigger-arg-path: bind:Binding >dobj [lemma='stat3'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='stat3'] themetdobj >nn Gene_or_gene_productt]e2: trigger-arg-path: Positive_activation nsubj [lemma='brca1'] Complext~e2: trigger-arg-path: promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlled:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='brca1'] controllertse2: trigger-arg-path: promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj Complext^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] theme:Gene_or_gene_productthe2: trigger-arg-path: Positive_activation nsubj [lemma='brca1'] controller:Complext|e2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='jak'] controlled:Gene_or_gene_producttQe2: trigger-arg-path: promote nsubj [lemma='brca1'] Complext]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='stat3'] theme:Gene_or_gene_producttee2: trigger-arg-path: promote:Positive_activation nsubj [lemma='brca1'] Complext&e2: ents2Label-mention-ngram: can bindtHe1: trigger-arg-path: Binding >dobj [lemma='stat3'] Gene_or_gene_producttSe1: trigger-arg-path: bind:Binding >dobj [lemma='stat3'] theme:Gene_or_gene_producttFe2: trigger-arg-path: promote:Positive_activation nsubj Complext9e1: trigger-arg-path: Binding >dobj [lemma='stat3'] themetXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='stat3'] Gene_or_gene_productt\e2: trigger-arg-path: promote nsubj [lemma='brca1'] controller:Complext`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: can bind SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn controlled:Gene_or_gene_productt:e2: ents2Label-mention-ngram: promote GENE_OR_GENE_PRODUCTt_trigger-to-trigger-path: e1:bind:Binding >vmod [lemma='promote'] e2:promote:Positive_activationtpe2: trigger-arg-path: promote:Positive_activation nsubj [lemma='brca1'] controller:Complextge2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='jak'] controlledtNe1: trigger-arg-path: Binding >dobj [lemma='stat3'] theme:Gene_or_gene_producttMe1: trigger-arg-path: bind:Binding >dobj [lemma='stat3'] Gene_or_gene_producttPe2: trigger-arg-path: promote:Positive_activation >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >nn controlledtFe2: trigger-arg-path: promote:Positive_activation >dobj >nn controlledtDe2: trigger-arg-path: lemmatizedTrigger=promote nsubj ComplextTe2: trigger-arg-path: promote nsubj [lemma='brca1'] controllertNe2: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='brca1'] controller:Complext=e2: ents2Label-mention-ngram: to promote GENE_OR_GENE_PRODUCTtce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj controller:Complext?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='brca1'] controller:ComplextPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='stat3'] themet[e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj controllertIe2: trigger-arg-path: promote:Positive_activation nsubj controllertEe1: trigger-arg-path: bind >dobj [lemma='stat3'] Gene_or_gene_producttQe2: trigger-arg-path: promote:Positive_activation nsubj controller:Complext?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlled:Gene_or_gene_producttje2: trigger-arg-path: promote >dobj [lemma='activation'] >nn [lemma='jak'] controlled:Gene_or_gene_productt2e2: trigger-arg-path: promote nsubj Complext7shortest-path: aux [lemma='can']tTe1: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='brca1'] controllertNe1: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] Gene_or_gene_productt?e1: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] themetGe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controllertMtrigger-to-trigger-path: e1:bind:Binding >vmod e2:promote:Positive_activationtKe1: trigger-arg-path: bind >dobj [lemma='stat3'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Complext2e2: trigger-arg-path: promote >dobj >nn controlledtDe2: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn controlledtve2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlled:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation nsubj [lemma='brca1'] ComplextWe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='stat3'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='jak'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >nn controlled:Gene_or_gene_productt5e2: trigger-arg-path: promote nsubj controllert{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlledt7e1: trigger-arg-path: bind >nsubj [lemma='brca1'] themet=e2: trigger-arg-path: promote nsubj controller:Complext`e2: trigger-arg-path: Positive_activation nsubj [lemma='brca1'] controllert/e2: ents2Label-mention-ngram: SHARED to promotetUe2: trigger-arg-path: promote >dobj [lemma='activation'] >nn [lemma='jak'] controlledtbe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: promote CONTROLLEDt_e2: trigger-arg-path: promote >dobj [lemma='activation'] >nn [lemma='jak'] Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER to promotet2e2: args2Role-mention-ngram: to promote CONTROLLEDt,e2: ents2Label-mention-ngram: bind SHARED tot6e1: trigger-arg-path: bind >dobj [lemma='stat3'] themetFe1: trigger-arg-path: bind >nsubj [lemma='brca1'] Gene_or_gene_producttLe1: trigger-arg-path: bind >nsubj [lemma='brca1'] theme:Gene_or_gene_producttae2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] controlledtke2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='jak'] Gene_or_gene_productt)e1: args2Role-mention-ngram: K56R reducedt4e1: args2Role-mention-ngram: CONTROLLER K56R reducedt4e1: args2Role-mention-ngram: K56R reduced CONTROLLEDtoe1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] Gene_or_gene_producttge1: trigger-arg-path: Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] Gene_or_gene_productt!e1: args2Role-mention-ngram: K56Rtre1: trigger-arg-path: Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controller:Gene_or_gene_producttee1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controller:Gene_or_gene_producttfshortest-path: ccomp [lemma='induce'] >nsubj [lemma='egf']t7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT K56Rt"e1: ents2Label-mention-ngram: K56Rt,e1: args2Role-mention-ngram: CONTROLLER K56Rt*e1: ents2Label-mention-ngram: K56R reducedt[e1: trigger-arg-path: reduced >nsubj [lemma='k56r'] >nn [lemma='grb2'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: K56R reduced SHAREDt]trigger-to-trigger-path: e1:reduced:Negative_regulation >ccomp e2:induced:Positive_regulationt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT K56R reducedtze1: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controller:Gene_or_gene_producttntrigger-to-trigger-path: e1:reduced:Negative_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationtwe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='k56r'] >nn [lemma='grb2'] controller:Gene_or_gene_producttfe1: trigger-arg-path: reduced >nsubj [lemma='k56r'] >nn [lemma='grb2'] controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='k56r'] >nn [lemma='grb2'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='k56r'] >nn [lemma='grb2'] controllertve1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controllertQe1: trigger-arg-path: reduced >nsubj [lemma='k56r'] >nn [lemma='grb2'] controllert]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='k56r'] >nn [lemma='grb2'] controllert3e2: ents2Label-mention-ngram: D1 and phosphorylatest(e1: trigger-arg-path: Binding >dobj sitet-e2: ents2Label-mention-ngram: binds cyclin D1t6e2: args2Role-mention-ngram: CONTROLLER directly bindstbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] themet7e1: trigger-arg-path: lemmatizedTrigger=bind >dobj sitet.e2: args2Role-mention-ngram: D1 and CONTROLLEDt'e2: ents2Label-mention-ngram: cyclin D1t-e1: ents2Label-mention-ngram: SHARED directlyt e1: ents2Label-mention-ngram: D1t&e2: args2Role-mention-ngram: cyclin D1t$e2: ents2Label-mention-ngram: Thr286t@e1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] site:Sitet*e2: args2Role-mention-ngram: cyclin D1 andt3e1: trigger-arg-path: binds >dobj [lemma='d1'] Sitetfe1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: binds cyclin D1t7e1: trigger-arg-path: lemmatizedTrigger=bind >dobj Sitet e2: ents2Label-mention-ngram: D1t(e1: trigger-arg-path: Binding >dobj Sitet`e1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj site:Sitet`e1: trigger-arg-path: Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt$e2: ents2Label-mention-ngram: D1 andt)e2: args2Role-mention-ngram: binds cyclint3e1: ents2Label-mention-ngram: directly binds SHAREDt+e1: trigger-arg-path: binds >dobj site:Sitet+e1: args2Role-mention-ngram: THEME directlyt.e1: trigger-arg-path: binds:Binding >dobj sitetZe1: trigger-arg-path: Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] >nn [lemma='cyclin'] themet+e2: ents2Label-mention-ngram: cyclin D1 andt8e1: trigger-arg-path: binds >dobj [lemma='d1'] site:SitetIe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] site:SitetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] site:Sitete2: args2Role-mention-ngram: D1t&e1: trigger-arg-path: binds >dobj sitet3e1: ents2Label-mention-ngram: SHARED directly bindst-e1: args2Role-mention-ngram: binds THEME SITEt0e2: args2Role-mention-ngram: CONTROLLER directlytqe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] >nn [lemma='cyclin'] Gene_or_gene_productt;e1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] sitet.e1: trigger-arg-path: binds:Binding >dobj Sitet&e1: trigger-arg-path: binds >dobj Sitet3e1: trigger-arg-path: binds:Binding >dobj site:Sitet-e1: trigger-arg-path: Binding >dobj site:Sitet#e2: args2Role-mention-ngram: D1 andt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj sitetIe1: trigger-arg-path: binds >dobj [lemma='d1'] >nn [lemma='cyclin'] themet2e2: args2Role-mention-ngram: directly binds cyclintLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] sitet5e1: trigger-arg-path: Binding >dobj [lemma='d1'] sitet$e2: ents2Label-mention-ngram: cyclint.e2: ents2Label-mention-ngram: SHARED at Thr286toe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt^e1: trigger-arg-path: binds >dobj [lemma='d1'] >nn [lemma='cyclin'] theme:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: directly binds THEMEt;e1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] Sitet'e2: ents2Label-mention-ngram: at Thr286tDe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] sitetLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='d1'] Sitet?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj Sitet5e1: trigger-arg-path: Binding >dobj [lemma='d1'] SitetKe1: trigger-arg-path: Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] themetQe1: trigger-arg-path: binds:Binding >dobj [lemma='d1'] >nn [lemma='cyclin'] themet*e2: ents2Label-mention-ngram: binds cyclint#e2: args2Role-mention-ngram: cyclint1e1: args2Role-mention-ngram: THEME directly bindstdobj site:Sitet?shortest-path: advmod [lemma='directly']t'e1: ents2Label-mention-ngram: SHARED D1t:e1: trigger-arg-path: Binding >dobj [lemma='d1'] site:Sitet'e1: args2Role-mention-ngram: THEME SITEtDe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='d1'] Sitet-e1: ents2Label-mention-ngram: binds SHARED D1tXe1: trigger-arg-path: binds >dobj [lemma='d1'] >nn [lemma='cyclin'] Gene_or_gene_productt3e1: trigger-arg-path: binds >dobj [lemma='d1'] sitet3e2: ents2Label-mention-ngram: directly binds cyclintTe1: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themetprep_of [lemma='nleh1'] themetRtrigger-to-trigger-path: e1:Binding:Binding prep_of [lemma='nleh1'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] themetdtrigger-to-trigger-path: e1:Binding:Binding prep_of [lemma='nleh1'] theme:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttke1: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttSe1: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themet{e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_producttie1: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themet-e2: ents2Label-mention-ngram: SHARED inhibitst\e1: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themetDe1: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] themetqe1: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] themetee1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: SHARED inhibits SHAREDtQe1: trigger-arg-path: Binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: to SHARED inhibitstce1: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_of [lemma='nleh1'] Gene_or_gene_productt[e2: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_between [lemma='raf'] themetCe1: trigger-arg-path: supports >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controller:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet0e1: args2Role-mention-ngram: supports CONTROLLEDtHinterceding-tokens-full-span: , but the selectivity of MCP110 to disruptt`e2: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitetse1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt8e1: args2Role-mention-ngram: Ras-GDP supports CONTROLLEDtztrigger-to-trigger-path: e1:supports:Positive_regulation >conj_but >nsubjpass >prep_of >vmod >dobj e2:interactions:Bindingt-e2: args2Role-mention-ngram: and THEME versustke1: trigger-arg-path: supports >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: supports GENE_OR_GENE_PRODUCTt?e2: trigger-arg-path: interactions:Binding >prep >pobj >nn Sitetve2: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet#e2: args2Role-mention-ngram: versustbe1: trigger-arg-path: supports:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt?e1: trigger-arg-path: supports:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controller:Gene_or_gene_producttLe2: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] Familyt,e2: args2Role-mention-ngram: GTPase and SITEtFe1: ents2Label-mention-ngram: supports GENE_OR_GENE_PRODUCT disruptiont+e1: args2Role-mention-ngram: Ras-GTP versustre1: trigger-arg-path: lemmatizedTrigger=support >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controllertprep >pobj >nn site:Sitet%e1: args2Role-mention-ngram: supportstHe2: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn sitetje2: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet#interceding-token ngrams: MCP110 tot'e2: args2Role-mention-ngram: GTPase andtje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj >prep_of controllert)e2: args2Role-mention-ngram: versus othert2e2: trigger-arg-path: Binding >prep >pobj >nn Sitet1e1: ents2Label-mention-ngram: SHARED with Ras-GTPt&e1: ents2Label-mention-ngram: supportst4e1: args2Role-mention-ngram: CONTROLLER with Ras-GTPtCe1: ents2Label-mention-ngram: Ras-GDP supports GENE_OR_GENE_PRODUCTtee2: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitethe1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj >prep_of Gene_or_gene_producttae2: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=support >nsubj >prep_of controllert,e1: ents2Label-mention-ngram: versus Ras-GDPt1e1: ents2Label-mention-ngram: with Ras-GTP versustLe2: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] themetve2: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitetue1: trigger-arg-path: supports:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controllertNe1: trigger-arg-path: supports >nsubj >prep_of controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] Gene_or_gene_producttDe2: trigger-arg-path: interactions >prep_between [lemma='ra'] Familyt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controller:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn Sitet3e1: args2Role-mention-ngram: Ras-GTP versus Ras-GDPt5e1: ents2Label-mention-ngram: versus Ras-GDP supportstee2: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitet+interceding-token ngrams: MCP110 to disruptt0e1: args2Role-mention-ngram: with Ras-GTP versust)e1: args2Role-mention-ngram: with Ras-GTPtve1: trigger-arg-path: supports >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controller:Gene_or_gene_productt=e2: trigger-arg-path: interactions >prep_between theme:Familyt?shortest-path: conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110'] >vmod [lemma='disrupt'] >dobj [lemma='interaction']tDe2: trigger-arg-path: interactions:Binding >prep >pobj >nn site:Sitet4e1: ents2Label-mention-ngram: Ras-GTP versus Ras-GDPt)e2: args2Role-mention-ngram: THEME versustde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] Gene_or_gene_productt#interceding-token ngrams: of MCP110tMe1: trigger-arg-path: supports:Positive_regulation >nsubj >prep_of controllertle1: trigger-arg-path: Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controllertTe1: trigger-arg-path: lemmatizedTrigger=support >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=support:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controllerte1: trigger: supportstSe2: trigger-arg-path: interactions >prep_between [lemma='raf'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet7e2: trigger-arg-path: interactions >prep_between FamilytDe2: trigger-arg-path: interactions >prep_between [lemma='raf'] themet$e1: args2Role-mention-ngram: Ras-GDPtKe2: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] themet!interceding-token ngrams: disruptte1: trigger-arg-path: supports:Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: versust0e2: args2Role-mention-ngram: versus other GTPaset#e2: args2Role-mention-ngram: GTPasetMe2: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn site:SitetYe2: trigger-arg-path: interactions >prep_between [lemma='raf'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:supports:Positive_regulation >conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110'] >vmod [lemma='disrupt'] >dobj [lemma='interaction'] e2:interactions:Bindingt.e1: ents2Label-mention-ngram: Ras-GDP supportst`e2: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitetHshortest-path: conj_but >nsubjpass >prep_of >vmod >dobjtPe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn sitetre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] theme:Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT disruptiontCe2: trigger-arg-path: interactions >prep_between [lemma='ra'] themet7e2: trigger-arg-path: interactions >prep >pobj >nn sitet,e1: ents2Label-mention-ngram: Ras-GTP versust4e1: args2Role-mention-ngram: versus Ras-GDP supportstme2: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet*e1: ents2Label-mention-ngram: with Ras-GTPt)e2: args2Role-mention-ngram: other GTPaset~e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitet?e1: trigger-arg-path: lemmatizedTrigger=support >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controller:Gene_or_gene_producttae1: trigger-arg-path: supports >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] controllert/e2: args2Role-mention-ngram: THEME versus othertEe2: trigger-arg-path: interactions:Binding >prep_between theme:Familyt-e2: args2Role-mention-ngram: other GTPase andtNe2: trigger-arg-path: Binding >prep_between [lemma='raf'] Gene_or_gene_productt?e2: trigger-arg-path: interactions:Binding >prep_between Familytee2: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet%e1: ents2Label-mention-ngram: Ras-GDPt|e1: trigger-arg-path: lemmatizedTrigger=support >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] Gene_or_gene_productt interceding-token ngrams: MCP110t&interceding-token ngrams: of MCP110 tot_e1: trigger-arg-path: lemmatizedTrigger=support >nsubj >prep_of controller:Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_between [lemma='raf'] theme:Gene_or_gene_producttre2: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:SitetWe1: trigger-arg-path: supports:Positive_regulation >nsubj >prep_of Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] themet/interceding-token ngrams: selectivity of MCP110t#e1: args2Role-mention-ngram: versust7e2: trigger-arg-path: interactions >prep >pobj >nn SitetUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn site:Sitet7e2: trigger-arg-path: Binding >prep >pobj >nn site:Sitetme2: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitet$interceding-token ngrams: to disruptt-e1: args2Role-mention-ngram: Ras-GDP supportst2e2: trigger-arg-path: Binding >prep >pobj >nn sitetve1: trigger-arg-path: Positive_regulation >nsubj [lemma='association'] >prep_of [lemma='raf-rbd'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn Sitet?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet+e1: args2Role-mention-ngram: versus Ras-GDPt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT disruption oft9e1: trigger-arg-path: supports >nsubj >prep_of controllert?e2: trigger-arg-path: interactions:Binding >prep >pobj >nn sitetUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] themetRe2: trigger-arg-path: interactions:Binding >prep_between [lemma='ra'] theme:FamilytJe2: trigger-arg-path: interactions >prep_between [lemma='ra'] theme:Familytae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] Gene_or_gene_productt9e1: trigger-arg-path: binds >prep_to [lemma='mst2'] themetNe1: trigger-arg-path: binds >prep_to [lemma='mst2'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='a-raf'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] themetGe1: trigger-arg-path: binds >nsubj [lemma='a-raf'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='a-raf'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] themetPe1: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] themetAe1: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a-raf'] themet@e1: trigger-arg-path: binds:Binding >nsubj [lemma='a-raf'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttztrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='seem'] >xcomp [lemma='promote'] e2:promote:Positive_activationtVe1: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds >nsubj [lemma='a-raf'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a-raf'] Gene_or_gene_producttYtrigger-to-trigger-path: e1:binds:Binding >conj_and >xcomp e2:promote:Positive_activationt8e1: trigger-arg-path: binds >nsubj [lemma='a-raf'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='mst2'] Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >nsubj [lemma='a-raf'] Gene_or_gene_productt[e2: trigger-arg-path: prevents:Positive_regulation >nsubj >appos >prep_of controller:Familytdobj [lemma='farnesylation'] controlledtJe2: trigger-arg-path: prevents >dobj [lemma='farnesylation'] Farnesylationt=e1: trigger-arg-path: prevents >dobj controlled:Farnesylationtee2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >appos >prep_of controllert+e1: ents2Label-mention-ngram: of the enzymetPe2: trigger-arg-path: prevents:Positive_regulation >nsubj >appos >prep_of Familytze1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='farnesylation'] controlled:FarnesylationtRe2: trigger-arg-path: Positive_regulation >nsubj >appos >prep_of controller:FamilytMe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >appos >prep_of Familytfe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] controlled:FarnesylationtQe1: trigger-arg-path: prevents:Negative_regulation >dobj controlled:Farnesylationt[e2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] Farnesylationt2e1: ents2Label-mention-ngram: farnesyl transferasetQe2: trigger-arg-path: prevents:Positive_regulation >dobj controlled:Farnesylationt.e1: ents2Label-mention-ngram: inhibitor of thet2e2: trigger-arg-path: prevents >dobj Farnesylationt5e1: ents2Label-mention-ngram: and selective inhibitortWe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj Farnesylationte2: trigger-arg-path: Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] Familyt@e1: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlledt[e1: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] Farnesylationt*e1: args2Role-mention-ngram: , efficientlyt9e1: ents2Label-mention-ngram: efficiently prevents SHAREDtYe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] Gene_or_gene_productte1: trigger: preventst?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controllert6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , atYe1: trigger-arg-path: prevents:Negative_regulation >nsubj controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: potenttCe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj Farnesylationt&e1: args2Role-mention-ngram: selectivet4e1: ents2Label-mention-ngram: farnesyl transferase (t,e2: args2Role-mention-ngram: ) , efficientlyt*e2: args2Role-mention-ngram: , efficientlyt/e2: trigger-arg-path: prevents >dobj controlledt)e1: args2Role-mention-ngram: CONTROLLER ,tDe1: trigger-arg-path: prevents:Negative_regulation >nsubj controllertle2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >appos >prep_of controller:Familyt)e1: args2Role-mention-ngram: inhibitor oft=e2: trigger-arg-path: prevents >dobj controlled:Farnesylationt*e1: args2Role-mention-ngram: and selectivet%e1: args2Role-mention-ngram: a potenttFe2: trigger-arg-path: prevents:Positive_regulation >dobj Farnesylationtje1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >appos >prep_of Familyt`e2: trigger-arg-path: Positive_regulation >dobj [lemma='farnesylation'] controlled:Farnesylationt&e1: ents2Label-mention-ngram: a potenttie1: trigger-arg-path: prevents:Negative_regulation >dobj [lemma='farnesylation'] controlled:Farnesylationt'e1: ents2Label-mention-ngram: selectivet1e1: args2Role-mention-ngram: farnesyl transferasetGe2: trigger-arg-path: prevents >dobj [lemma='farnesylation'] controlledt?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controller:FamilytJe1: trigger-arg-path: prevents >dobj [lemma='farnesylation'] Farnesylationtce1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='III'] controllert-e2: ents2Label-mention-ngram: prevents SHAREDt%e1: args2Role-mention-ngram: farnesylt'e2: ents2Label-mention-ngram: ( FTase )t0e1: args2Role-mention-ngram: prevents CONTROLLEDtme1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='III'] Gene_or_gene_productt&e1: args2Role-mention-ngram: inhibitort\e1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='III'] Gene_or_gene_productt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='III'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: farnesyltCe2: trigger-arg-path: prevents:Positive_regulation >dobj controlledt-e1: args2Role-mention-ngram: inhibitor of thetnsubj >appos >prep_of FamilytUe1: trigger-arg-path: prevents >dobj [lemma='farnesylation'] controlled:Farnesylationt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controllertoe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='farnesylation'] Farnesylationt4e1: args2Role-mention-ngram: and selective inhibitortXe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] controlledtVe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER ( FTaset#e1: args2Role-mention-ngram: potenttHe2: trigger-arg-path: Positive_regulation >dobj controlled:Farnesylationte2: trigger-arg-path: prevents >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controller:Familyt+e2: ents2Label-mention-ngram: , efficientlyt-e1: ents2Label-mention-ngram: ) , efficientlyt,e1: args2Role-mention-ngram: enzyme farnesylt9e2: ents2Label-mention-ngram: efficiently prevents SHAREDt2e1: trigger-arg-path: prevents >dobj Farnesylationt)e1: ents2Label-mention-ngram: transferasetfe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] controlled:FarnesylationtTe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj controlledtHe1: trigger-arg-path: Negative_regulation >dobj controlled:Farnesylationt1e1: ents2Label-mention-ngram: selective inhibitortSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='III'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] FamilytXe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='farnesylation'] controlledt)e2: ents2Label-mention-ngram: efficientlytde1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: FTase ) ,t3e1: args2Role-mention-ngram: , efficiently preventst^e1: trigger-arg-path: prevents:Negative_regulation >dobj [lemma='farnesylation'] Farnesylationt*e1: args2Role-mention-ngram: of the enzymetTe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj controlledt(e1: ents2Label-mention-ngram: , a potenttUe2: trigger-arg-path: prevents >dobj [lemma='farnesylation'] controlled:Farnesylationt'e2: ents2Label-mention-ngram: FTase ) ,t+e2: ents2Label-mention-ngram: farnesylationt1e1: ents2Label-mention-ngram: the enzyme farnesyltte2: trigger-arg-path: prevents >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] FamilytFe1: trigger-arg-path: prevents:Negative_regulation >dobj Farnesylationt?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controller:Familytnsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: prevents:Negative_regulation >dobj [lemma='farnesylation'] controlledt+e1: ents2Label-mention-ngram: transferase (t3e2: args2Role-mention-ngram: , efficiently preventst?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controller:Familyt2e1: ents2Label-mention-ngram: efficiently preventst2e2: ents2Label-mention-ngram: SHARED farnesylationt@e2: trigger-arg-path: prevents >nsubj >appos >prep_of controllert&e1: args2Role-mention-ngram: ( FTase )t=e1: trigger-arg-path: Negative_regulation >dobj Farnesylationtbe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj controlled:FarnesylationtWe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj Farnesylationt&e2: args2Role-mention-ngram: ( FTase )tTe2: trigger-arg-path: prevents:Positive_regulation >nsubj >appos >prep_of controllert;e2: ents2Label-mention-ngram: prevents SHARED farnesylationtGe2: trigger-arg-path: prevents >nsubj >appos >prep_of controller:Familyt4e1: ents2Label-mention-ngram: , efficiently preventstCe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj Farnesylationt:e1: trigger-arg-path: prevents >nsubj Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='farnesylation'] controlled:Farnesylationtxe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='III'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: FTase )tie2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='farnesylation'] controlled:Farnesylationt2e1: ents2Label-mention-ngram: potent and selectivet'e1: args2Role-mention-ngram: , a potenttKe2: trigger-arg-path: Positive_regulation >nsubj >appos >prep_of controllertOe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] controllertHe1: trigger-arg-path: prevents >nsubj [lemma='III'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: prevents SHAREDt%e1: ents2Label-mention-ngram: ( FTaset1e1: ents2Label-mention-ngram: transferase ( FTaset$e1: args2Role-mention-ngram: ( FTasetUe2: trigger-arg-path: Positive_regulation >dobj [lemma='farnesylation'] Farnesylationt%e1: ents2Label-mention-ngram: FTase )tXe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >appos >prep_of controller:Familyt_e1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj Gene_or_gene_productt1e1: args2Role-mention-ngram: efficiently preventst(e1: args2Role-mention-ngram: transferaset(e1: ents2Label-mention-ngram: the enzymetNe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlled:Farnesylationt$e2: args2Role-mention-ngram: ( FTasetZshortest-path: appos [lemma='inhibitor'] >prep_of [lemma='transferase']t&e2: ents2Label-mention-ngram: FAMILY (t'e1: ents2Label-mention-ngram: ( FTase )t9e1: ents2Label-mention-ngram: enzyme farnesyl transferaset(e2: args2Role-mention-ngram: efficientlyt`e1: trigger-arg-path: Negative_regulation >dobj [lemma='farnesylation'] controlled:Farnesylationt-e1: ents2Label-mention-ngram: enzyme farnesyltxe2: trigger-arg-path: prevents >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controllert)e1: ents2Label-mention-ngram: efficientlyt(e1: ents2Label-mention-ngram: potent andt;e1: ents2Label-mention-ngram: prevents SHARED farnesylationt^e2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='farnesylation'] FarnesylationtCe1: trigger-arg-path: prevents:Negative_regulation >dobj controlledtQe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >appos >prep_of controllert0e1: args2Role-mention-ngram: selective inhibitort,e2: ents2Label-mention-ngram: FAMILY ( FTaset+e1: ents2Label-mention-ngram: , efficientlytKe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj Gene_or_gene_producttRe2: trigger-arg-path: Positive_regulation >dobj [lemma='farnesylation'] controlledtSe1: trigger-arg-path: prevents >nsubj [lemma='III'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controllert'e1: ents2Label-mention-ngram: FTase ) ,t@e2: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlledt[e2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='farnesylation'] controlledtle1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='farnesylation'] controlledt'e1: args2Role-mention-ngram: the enzymet1e1: args2Role-mention-ngram: potent and selectivet0e1: args2Role-mention-ngram: the enzyme farnesyltle2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='farnesylation'] controlledt=e2: trigger-arg-path: Positive_regulation >dobj Farnesylationt+e1: ents2Label-mention-ngram: and selectivet0e2: args2Role-mention-ngram: prevents CONTROLLEDt"shortest-path: appos >prep_oft?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] Familyt$e2: args2Role-mention-ngram: FTase )tbe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj controlled:Farnesylationt?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controllert%e1: args2Role-mention-ngram: preventstNe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlled:Farnesylationt'e1: args2Role-mention-ngram: potent andtIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='III'] controllert#e1: ents2Label-mention-ngram: FTaset"e2: args2Role-mention-ngram: FTaset3e1: args2Role-mention-ngram: selective inhibitor oft-e2: ents2Label-mention-ngram: ) , efficientlytUe1: trigger-arg-path: Negative_regulation >dobj [lemma='farnesylation'] Farnesylationt*e1: args2Role-mention-ngram: transferase (t0e1: args2Role-mention-ngram: transferase ( FTasetNe1: trigger-arg-path: prevents:Negative_regulation >nsubj Gene_or_gene_productt1e2: args2Role-mention-ngram: efficiently preventst/e1: trigger-arg-path: prevents >dobj controlledt&e1: ents2Label-mention-ngram: preventst3e1: args2Role-mention-ngram: farnesyl transferase (t?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] FamilytRe1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='III'] controllert*e1: ents2Label-mention-ngram: a potent andt,e1: args2Role-mention-ngram: ) , efficientlytGe2: trigger-arg-path: Positive_regulation >nsubj >appos >prep_of Familyt"e1: args2Role-mention-ngram: FTaset+e1: args2Role-mention-ngram: CONTROLLER , at8e1: args2Role-mention-ngram: enzyme farnesyl transferasetoe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='farnesylation'] Farnesylationtge1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='III'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: , efficiently preventst2e2: ents2Label-mention-ngram: efficiently preventst#e2: ents2Label-mention-ngram: FTaset?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='III'] >appos [lemma='inhibitor'] >prep_of [lemma='transferase'] controller:Familyt0e1: trigger-arg-path: prevents >nsubj controllert4e1: ents2Label-mention-ngram: selective inhibitor oft>e1: trigger-arg-path: prevents >nsubj [lemma='III'] controllertRe1: trigger-arg-path: Negative_regulation >dobj [lemma='farnesylation'] controlledt(e1: args2Role-mention-ngram: efficientlytRe2: trigger-arg-path: activated:Positive_activation ccomp >prep_at >dep >dobj >prep_of >amodt_e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation e2: trigger-arg-path: lemmatizedTrigger=activate ccomp [lemma='event'] >prep_at [lemma='end'] >dep [lemma='induce'] >dobj [lemma='binding'] >prep_of [lemma='jun'] >amod [lemma='activate']t-interceding-token ngrams: inducing binding oftDe2: trigger-arg-path: activated:Positive_activation e2: trigger-arg-path: activated ccomp >prep_at >dep >dobj >prep_of >amod e2:activated:Positive_activationt:e2: trigger-arg-path: Positive_activation e2: trigger-arg-path: activated ccomp [lemma='event'] >prep_at [lemma='end'] >dep [lemma='induce'] >dobj [lemma='binding'] >prep_of [lemma='jun'] >amod [lemma='activate'] e2:activated:Positive_activationtxe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controllert-e1: ents2Label-mention-ngram: , blocks SHAREDt!e1: args2Role-mention-ngram: PIA6t+e1: args2Role-mention-ngram: lipid analoguet"e1: args2Role-mention-ngram: lipidtoe1: trigger-arg-path: blocks >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controller:Gene_or_gene_producttAe1: trigger-arg-path: blocks >nsubj >prep_of Gene_or_gene_productt%e1: args2Role-mention-ngram: PIA6 , atne1: trigger-arg-path: blocks:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controllert?e1: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] Gene_or_gene_productt"e1: args2Role-mention-ngram: ethertTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='bdnf'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >nsubj >prep_of controllert\e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='bdnf'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: with PIA6 ,tRe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='bdnf'] controllert%e1: args2Role-mention-ngram: , blockst=e1: args2Role-mention-ngram: phosphatidylinositol ether lipidtge1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controllert&e1: ents2Label-mention-ngram: , blockst(e1: args2Role-mention-ngram: with PIA6 ,tke1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controllert#e1: ents2Label-mention-ngram: lipidt/e1: ents2Label-mention-ngram: analogue , blockstce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='bdnf'] controllert#e1: ents2Label-mention-ngram: ethert(e1: ents2Label-mention-ngram: analogue ,tOe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='bdnf'] controllertUe1: trigger-arg-path: blocks:Positive_regulation >nsubj >prep_of Gene_or_gene_productt`e1: trigger-arg-path: blocks:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttde1: trigger-arg-path: blocks >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] Gene_or_gene_producttqshortest-path: ccomp [lemma='induce'] >nsubj [lemma='bdnf']tde2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='bdnf'] controller:Gene_or_gene_producttqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] Gene_or_gene_producttge2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='bdnf'] controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: with PIA6t&e1: ents2Label-mention-ngram: PIA6 , at>e1: ents2Label-mention-ngram: phosphatidylinositol ether lipidt?e1: trigger-arg-path: blocks:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controller:Gene_or_gene_producttZe1: trigger-arg-path: blocks >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controllert1e1: args2Role-mention-ngram: phosphatidylinositolt'e1: args2Role-mention-ngram: analogue ,t|e1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: ether lipid analoguet,e1: ents2Label-mention-ngram: lipid analoguetYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='bdnf'] Gene_or_gene_productt>e2: trigger-arg-path: induced >nsubj [lemma='bdnf'] controllert+e1: ents2Label-mention-ngram: blocks SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: lipid analogue ,tLe1: trigger-arg-path: blocks >nsubj >prep_of controller:Gene_or_gene_productt\trigger-to-trigger-path: e1:blocks:Positive_regulation >ccomp e2:induced:Positive_regulationt+e1: ents2Label-mention-ngram: SHARED , withtSe2: trigger-arg-path: induced >nsubj [lemma='bdnf'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: blocks CONTROLLEDtmtrigger-to-trigger-path: e1:blocks:Positive_regulation >ccomp [lemma='induce'] e2:induced:Positive_regulationt.e1: args2Role-mention-ngram: CONTROLLER , witht)e1: ents2Label-mention-ngram: , with PIA6t3e1: args2Role-mention-ngram: a phosphatidylinositolt9e1: args2Role-mention-ngram: a phosphatidylinositol ethert"e1: ents2Label-mention-ngram: PIA6tHe2: trigger-arg-path: induced >nsubj [lemma='bdnf'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: with PIA6txe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='bdnf'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: ether lipidt?e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='bdnf'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: PIA6 ,t%e1: args2Role-mention-ngram: analoguet4e1: ents2Label-mention-ngram: a phosphatidylinositolt-e1: args2Role-mention-ngram: lipid analogue ,t&e1: ents2Label-mention-ngram: analoguet7e1: args2Role-mention-ngram: phosphatidylinositol ethert$e1: ents2Label-mention-ngram: , witht6e1: ents2Label-mention-ngram: , a phosphatidylinositolt0e1: args2Role-mention-ngram: , blocks CONTROLLEDtfe1: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >nsubj >prep_of Gene_or_gene_productt7e1: trigger-arg-path: blocks >nsubj >prep_of controllert1e1: args2Role-mention-ngram: ether lipid analoguetue1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='bdnf'] Gene_or_gene_productt.e1: args2Role-mention-ngram: analogue , blockst8e1: ents2Label-mention-ngram: phosphatidylinositol ethert5e1: args2Role-mention-ngram: , a phosphatidylinositoltKe1: trigger-arg-path: blocks:Positive_regulation >nsubj >prep_of controllert(e1: args2Role-mention-ngram: , with PIA6t(e1: args2Role-mention-ngram: ether lipidtxe1: trigger-arg-path: blocks:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='akt'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: blocks SHARED inducedtJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='bdnf'] controllert#e1: args2Role-mention-ngram: PIA6 ,tqe1: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: , witht:e1: ents2Label-mention-ngram: a phosphatidylinositol etherte1: trigger: inducet&e1: args2Role-mention-ngram: unable tot]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='c-cbl'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hsprouty2'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=induce nsubj Simple_chemicaltprep_to [lemma='c-cbl'] themetae1: trigger-arg-path: Positive_regulation nsubj [lemma='pga'] controllertRe2: trigger-arg-path: binding:Binding >nn [lemma='hsprouty2'] Gene_or_gene_producttXe2: trigger-arg-path: binding:Binding >nn [lemma='hsprouty2'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: 1 was unablet1e1: args2Role-mention-ngram: hSprouty2 CONTROLLEDtUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hsprouty2'] themet/e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL 1tTe1: trigger-arg-path: induce nsubj [lemma='pga'] controllertme1: trigger-arg-path: induce:Positive_regulation nsubj [lemma='pga'] Simple_chemicaltCe2: trigger-arg-path: binding:Binding >nn [lemma='hsprouty2'] themetPe2: trigger-arg-path: Binding >nn [lemma='hsprouty2'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='c-cbl'] themet#e1: ents2Label-mention-ngram: 1 wast"e1: args2Role-mention-ngram: 1 wast-e1: args2Role-mention-ngram: CONTROLLER 1 wast-e1: args2Role-mention-ngram: induce hSprouty2tnshortest-path: xcomp [lemma='induce'] >dobj [lemma='binding'] >nn [lemma='hsprouty2']tOtrigger-to-trigger-path: e1:induce:Positive_regulation >dobj e2:binding:Bindingt[e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj controllerte1: incoming: nsubj [lemma='pga'] Simple_chemicalt3e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL 1 wastKe2: trigger-arg-path: Binding >prep_to [lemma='c-cbl'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: unablet1e1: ents2Label-mention-ngram: to induce hSprouty2t.e1: ents2Label-mention-ngram: unable to inducet'e1: args2Role-mention-ngram: was unablet\e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hsprouty2'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: was unabletKe2: trigger-arg-path: binding >prep_to [lemma='c-cbl'] Gene_or_gene_producttEe1: trigger-arg-path: induce nsubj controller:Simple_chemicalt'e1: ents2Label-mention-ngram: unable totJe2: trigger-arg-path: binding >nn [lemma='hsprouty2'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: inducet#e1: args2Role-mention-ngram: unablet;e2: trigger-arg-path: binding >nn [lemma='hsprouty2'] themetRe1: trigger-arg-path: Positive_regulation nsubj controller:Simple_chemicaltje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hsprouty2'] theme:Gene_or_gene_productthe1: trigger-arg-path: induce:Positive_regulation nsubj [lemma='pga'] controllert7e1: ents2Label-mention-ngram: induce hSprouty2 tyrosinet?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='pga'] controller:Simple_chemicalt`e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj Simple_chemicaltWe1: trigger-arg-path: lemmatizedTrigger=induce nsubj controller:Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='c-cbl'] themet&e1: args2Role-mention-ngram: hSprouty2tQe2: trigger-arg-path: binding >prep_to [lemma='c-cbl'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='c-cbl'] theme:Gene_or_gene_producttYe1: trigger-arg-path: induce:Positive_regulation nsubj controller:Simple_chemicaltMe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hsprouty2'] themetfe1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='pga'] controllert+e1: ents2Label-mention-ngram: was unable tot-e1: args2Role-mention-ngram: unable to inducetPe2: trigger-arg-path: binding >nn [lemma='hsprouty2'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: hSprouty2t)e1: ents2Label-mention-ngram: , or SHAREDt#e1: args2Role-mention-ngram: inducet0e1: args2Role-mention-ngram: to induce hSprouty2tke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='c-cbl'] theme:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='pga'] controller:Simple_chemicaltqe1: trigger-arg-path: Positive_regulation nsubj [lemma='pga'] controller:Simple_chemicaltee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='c-cbl'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='pga'] Simple_chemicaltde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hsprouty2'] Gene_or_gene_producttprep_to [lemma='c-cbl'] themet&e1: args2Role-mention-ngram: to inducet8e1: ents2Label-mention-ngram: tyrosine phosphorylation ,t2e1: ents2Label-mention-ngram: phosphorylation , ortQe2: trigger-arg-path: Binding >prep_to [lemma='c-cbl'] theme:Gene_or_gene_productt@e1: ents2Label-mention-ngram: hSprouty2 tyrosine phosphorylationt;e2: trigger-arg-path: Binding >nn [lemma='hsprouty2'] themetDe2: trigger-arg-path: binding:Binding >prep_to [lemma='c-cbl'] themetSe2: trigger-arg-path: binding:Binding >prep_to [lemma='c-cbl'] Gene_or_gene_productt8e1: args2Role-mention-ngram: induce hSprouty2 CONTROLLEDtfe1: trigger-arg-path: Positive_regulation nsubj [lemma='pga'] Simple_chemicalt'e1: ents2Label-mention-ngram: to inducetNe1: trigger-arg-path: induce:Positive_regulation nsubj Simple_chemicaltke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj controller:Simple_chemicaltatrigger-to-trigger-path: e1:induce:Positive_regulation >dobj [lemma='binding'] e2:binding:Bindingtze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='pga'] controllertIe1: trigger-arg-path: induce:Positive_regulation nsubj controllert5e1: trigger-arg-path: induce nsubj controllert)e1: args2Role-mention-ngram: 1 was unabletJe2: trigger-arg-path: Binding >nn [lemma='hsprouty2'] Gene_or_gene_producttxe1: trigger-arg-path: induce:Positive_regulation nsubj [lemma='pga'] controller:Simple_chemicaltde1: trigger-arg-path: induce nsubj [lemma='pga'] controller:Simple_chemicaltYe1: trigger-arg-path: induce nsubj [lemma='pga'] Simple_chemicalt:e1: trigger-arg-path: induce nsubj Simple_chemicalt0e1: ents2Label-mention-ngram: hSprouty2 tyrosinetGe1: trigger-arg-path: lemmatizedTrigger=induce nsubj controllertGe1: trigger-arg-path: Positive_regulation nsubj Simple_chemicalt*e1: args2Role-mention-ngram: was unable totYe2: trigger-arg-path: binding:Binding >prep_to [lemma='c-cbl'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: induce hSprouty2t?e2: trigger-arg-path: complex:Binding >nn [lemma='keap1'] themetoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cul3'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='nrf2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cul3'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='cul3'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cul3'] themetSe2: trigger-arg-path: complex:Binding >nn [lemma='cul3'] theme:Gene_or_gene_producttTe2: trigger-arg-path: complex:Binding >nn [lemma='keap1'] theme:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='cul3'] theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='keap1'] theme:Gene_or_gene_productt^e1: trigger-arg-path: binding:Binding >prep_between [lemma='keap1'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='nrf2'] themet,interceding-token ngrams: ligase activity oft?trigger-to-trigger-path: e1:binding:Binding conj_and [lemma='inactivate'] >nsubjpass [lemma='activity'] >prep_of [lemma='complex'] e2:complex:BindingtHe1: trigger-arg-path: binding:Binding >prep_between [lemma='nrf2'] themetKe2: trigger-arg-path: Binding >nn [lemma='cul3'] theme:Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >prep_between [lemma='keap1'] Gene_or_gene_productt'interceding-token ngrams: the E3 ligasetUe1: trigger-arg-path: binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding >prep_between [lemma='nrf2'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='keap1'] themetEe2: trigger-arg-path: Binding >nn [lemma='cul3'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='cul3'] themetbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='keap1'] Gene_or_gene_productt?shortest-path: conj_and [lemma='inactivate'] >nsubjpass [lemma='activity'] >prep_of [lemma='complex'] >nn [lemma='keap1']tSe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='keap1'] themet]e1: trigger-arg-path: binding:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='cul3'] themetPe1: trigger-arg-path: Binding >prep_between [lemma='keap1'] Gene_or_gene_productt(interceding-token ngrams: is disrupted ,t$interceding-token ngrams: and the E3tae1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='nrf2'] Gene_or_gene_producttWe1: trigger-arg-path: binding:Binding >prep_between [lemma='nrf2'] Gene_or_gene_productt%interceding-token ngrams: disrupted ,tNinterceding-tokens-full-span: is disrupted , and the E3 ligase activity of thet interceding-token ngrams: the E3tLe2: trigger-arg-path: complex >nn [lemma='keap1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='keap1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='keap1'] theme:Gene_or_gene_producttAe1: trigger-arg-path: binding >prep_between [lemma='keap1'] themetFe2: trigger-arg-path: complex >nn [lemma='keap1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cul3'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='cul3'] themet#interceding-token ngrams: disruptedtPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cul3'] themetIe1: trigger-arg-path: binding:Binding >prep_between [lemma='keap1'] themetVe1: trigger-arg-path: Binding >prep_between [lemma='keap1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='keap1'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='keap1'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='cul3'] Gene_or_gene_productt#interceding-token ngrams: E3 ligasetje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_between [lemma='keap1'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='keap1'] themetAe1: trigger-arg-path: Binding >prep_between [lemma='keap1'] themethe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='keap1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='nrf2'] themetNe2: trigger-arg-path: complex:Binding >nn [lemma='keap1'] Gene_or_gene_productt7e2: trigger-arg-path: complex >nn [lemma='keap1'] themet&interceding-token ngrams: is disruptedt@e1: trigger-arg-path: binding >prep_between [lemma='nrf2'] themetIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='keap1'] themetge1: trigger-arg-path: lemmatizedTrigger=binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productt)interceding-token ngrams: disrupted , andtPe1: trigger-arg-path: binding >prep_between [lemma='keap1'] Gene_or_gene_productt,interceding-token ngrams: E3 ligase activitytVe1: trigger-arg-path: binding >prep_between [lemma='keap1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cul3'] theme:Gene_or_gene_productt;shortest-path: conj_and >nsubjpass >prep_of >nntgtrigger-to-trigger-path: e1:binding:Binding conj_and >nsubjpass >prep_of e2:complex:Bindingt.e1: ents2Label-mention-ngram: expression formst-e2: ents2Label-mention-ngram: , which furthert:e1: ents2Label-mention-ngram: induced GENE_OR_GENE_PRODUCTt(e1: ents2Label-mention-ngram: with HDAC1t0e1: ents2Label-mention-ngram: expression forms at,e2: args2Role-mention-ngram: , which furthert#e1: ents2Label-mention-ngram: HDAC1t1e2: ents2Label-mention-ngram: which further bindst.e2: ents2Label-mention-ngram: further binds tot*e2: args2Role-mention-ngram: which furthert*e2: args2Role-mention-ngram: further bindstatrigger-to-trigger-path: e1:induced:Positive_regulation >ccomp >prep_with >rcmod e2:binds:Bindingt0e2: args2Role-mention-ngram: which further bindst+e2: ents2Label-mention-ngram: further bindst'shortest-path: ccomp >prep_withtWshortest-path: ccomp [lemma='form'] >prep_with [lemma='hdac1']t+e2: ents2Label-mention-ngram: which furthert-e2: args2Role-mention-ngram: further binds tot'e1: ents2Label-mention-ngram: HDAC1 andtCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT expression formst$e2: args2Role-mention-ngram: furthertEe1: ents2Label-mention-ngram: induced GENE_OR_GENE_PRODUCT expressiont,e1: ents2Label-mention-ngram: with HDAC1 andt0e1: ents2Label-mention-ngram: complex with HDAC1t.e1: ents2Label-mention-ngram: HDAC1 and SHAREDt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and Sp1t?trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp [lemma='form'] >prep_with [lemma='hdac1'] >rcmod [lemma='bind'] e2:binds:BindingtAe1: ents2Label-mention-ngram: FAMILY induced GENE_OR_GENE_PRODUCTtYe1: trigger-arg-path: form a complex:Binding nsubj theme:Gene_or_gene_producttwe1: trigger-arg-path: form a complex:Binding nsubj [lemma='beta1ar'] themet7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT formtze1: trigger-arg-path: Binding nsubj [lemma='egfr'] theme:Gene_or_gene_productt?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='egfr'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='egfr'] theme:Gene_or_gene_productt;e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT formtKe1: trigger-arg-path: form a complex nsubj Gene_or_gene_producttSe1: trigger-arg-path: form a complex:Binding nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='beta1ar'] theme:Gene_or_gene_producttee1: trigger-arg-path: Binding nsubj [lemma='egfr'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='egfr'] themethe1: trigger-arg-path: Binding nsubj [lemma='beta1ar'] themet?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='beta1ar'] Gene_or_gene_productt?e1: trigger-arg-path: form a complex nsubj [lemma='beta1ar'] theme:Gene_or_gene_producttoe1: trigger-arg-path: form a complex nsubj [lemma='beta1ar'] themet~e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='egfr'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='beta1ar'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='beta1ar'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='beta1ar'] Gene_or_gene_productt,shortest-path: conj_and >nsubj >posst?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='beta1ar'] themet&interceding-token ngrams: membrane andtDe1: trigger-arg-path: form a complex:Binding nsubj themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='egfr'] theme:Gene_or_gene_producttnsubj themetle1: trigger-arg-path: form a complex nsubj [lemma='egfr'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='egfr'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT form at?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='egfr'] Gene_or_gene_producttwe1: trigger-arg-path: Binding nsubj [lemma='beta1ar'] Gene_or_gene_productt?trigger-to-trigger-path: e1:form a complex:Binding conj_and [lemma='depend'] >nsubj [lemma='interaction'] e2:interaction:Bindingt+e1: args2Role-mention-ngram: and THEME formt-interceding-token ngrams: plasma membrane andt?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='egfr'] theme:Gene_or_gene_productt?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='beta1ar'] theme:Gene_or_gene_producttte1: trigger-arg-path: form a complex:Binding nsubj [lemma='egfr'] themetqshortest-path: conj_and [lemma='depend'] >nsubj [lemma='interaction'] >poss [lemma='they']tte1: trigger-arg-path: Binding nsubj [lemma='egfr'] Gene_or_gene_productt{e1: trigger-arg-path: form a complex nsubj [lemma='egfr'] Gene_or_gene_producttQe1: trigger-arg-path: form a complex nsubj theme:Gene_or_gene_productt?e1: trigger-arg-path: form a complex nsubj [lemma='egfr'] theme:Gene_or_gene_producttetrigger-to-trigger-path: e1:form a complex:Binding conj_and >nsubj e2:interaction:Bindingt'interceding-token ngrams: at the plasmat?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='beta1ar'] Gene_or_gene_productt}e1: trigger-arg-path: Binding nsubj [lemma='beta1ar'] theme:Gene_or_gene_productt~e1: trigger-arg-path: form a complex nsubj [lemma='beta1ar'] Gene_or_gene_productt8interceding-tokens-full-span: at the plasma membrane andtotrigger-to-trigger-path: e1:impair:Negative_regulation >dobj [lemma='interaction'] e2:interaction:Generic_eventt|e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding nn [lemma='raf'] themetTe2: trigger-arg-path: complex:Binding nn [lemma='ra'] themetSe1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation nn [lemma='raf'] themetdobj controlledt=e1: trigger-arg-path: Negative_regulation >dobj Generic_eventt,e2: trigger-arg-path: complex nn FamilytUe1: trigger-arg-path: lemmatizedTrigger=impair >dobj [lemma='interaction'] controlledtge2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] themet2e1: args2Role-mention-ngram: impair the CONTROLLEDtZe1: trigger-arg-path: impair:Negative_regulation >dobj [lemma='interaction'] Generic_eventtKe1: trigger-arg-path: Negative_regulation dobj [lemma='interaction'] controlled:Generic_eventtBe1: trigger-arg-path: impair e2: trigger-arg-path: lemmatizedTrigger=complex nn FamilytYtrigger-to-trigger-path: e1:impair:Negative_regulation >dobj e2:interaction:Generic_eventt-e1: trigger-arg-path: impair >dobj controlledt5e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT tot*e1: args2Role-mention-ngram: to impair thet0e1: trigger-arg-path: impair >dobj Generic_eventtfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ra'] themet$e1: ents2Label-mention-ngram: impairt_e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] Familyt=e2: ents2Label-mention-ngram: FAMILY and GENE_OR_GENE_PRODUCTtRe1: trigger-arg-path: impair:Negative_regulation nn FamilytSe2: trigger-arg-path: complex nn [lemma='ra'] theme:Familyt:e1: trigger-arg-path: Negative_regulation dobj controlled:Generic_eventtBe1: trigger-arg-path: lemmatizedTrigger=impair >dobj Generic_eventtSe1: trigger-arg-path: Negative_regulation >dobj [lemma='interaction'] Generic_eventtMe1: trigger-arg-path: lemmatizedTrigger=impair >dobj controlled:Generic_eventtOe1: trigger-arg-path: Negative_regulation nn [lemma='raf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: impair:Negative_regulation >dobj Generic_eventtee2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] theme:FamilytLe2: trigger-arg-path: complex nn [lemma='ra'] themetAe1: trigger-arg-path: impair:Negative_regulation nn [lemma='raf'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='ra'] theme:Familytie1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation >dobj [lemma='interaction'] controlledtne1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation dobj [lemma='interaction']tAe1: trigger-arg-path: impair:Negative_regulation >dobj controlledtSe2: trigger-arg-path: Binding nn [lemma='ra'] theme:FamilytUe2: trigger-arg-path: complex:Binding nn [lemma='ra'] Familytde2: trigger-arg-path: complex:Binding nn [lemma='raf'] Gene_or_gene_productt#e1: args2Role-mention-ngram: impairt:e2: trigger-arg-path: complex:Binding nn theme:Familyt_e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='raf'] themet7e1: trigger-arg-path: impair nn [lemma='raf'] theme:Gene_or_gene_producttee1: trigger-arg-path: impair:Negative_regulation >dobj [lemma='interaction'] controlled:Generic_eventtQe1: trigger-arg-path: impair >dobj [lemma='interaction'] controlled:Generic_eventtKe1: trigger-arg-path: impair:Negative_regulation dobj [lemma='interaction'] controlled:Generic_eventt\e2: trigger-arg-path: Binding nn [lemma='raf'] Gene_or_gene_productt7e1-label: Negative_regulation + e2-label: Generic_eventt^e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='ra'] themetPe1: trigger-arg-path: lemmatizedTrigger=impair dobj [lemma='interaction'] Generic_eventtUe2: trigger-arg-path: complex:Binding nn [lemma='raf'] themetde1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation dobj [lemma='interaction'] controlledtDe1: trigger-arg-path: Negative_regulation dobj controlled:Generic_eventtFe1: trigger-arg-path: impair >dobj [lemma='interaction'] Generic_eventt'e1: ents2Label-mention-ngram: to impairtIe1: trigger-arg-path: lemmatizedTrigger=impair dobj controlled:Generic_eventtLe2: trigger-arg-path: Binding nn [lemma='ra'] themetee1: trigger-arg-path: lemmatizedTrigger=impair nn [lemma='raf'] Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER to impairt?e1: trigger-arg-path: lemmatizedTrigger=impair dobj controlledtPe1: trigger-arg-path: Negative_regulation >dobj [lemma='interaction'] controlledt'e1: args2Role-mention-ngram: impair thet+e1: ents2Label-mention-ngram: to impair thetZe1: trigger-arg-path: lemmatizedTrigger=impair nn theme:Familyt4e1: ents2Label-mention-ngram: impair the interactiontWe1: trigger-arg-path: impair:Negative_regulation >dobj [lemma='interaction'] controlledtDe2: trigger-arg-path: lemmatizedTrigger=complex nn theme:Familytte2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='raf'] theme:Gene_or_gene_productt4e2: trigger-arg-path: complex:Binding nn Familyt^e1: trigger-arg-path: Negative_regulation >dobj [lemma='interaction'] controlled:Generic_eventt[e2: trigger-arg-path: complex:Binding nn [lemma='ra'] theme:FamilytMe2: trigger-arg-path: Binding nn [lemma='ra'] Familytve2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='raf'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=impair nn [lemma='raf'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation nn [lemma='ra'] FamilytXe1: trigger-arg-path: lemmatizedTrigger=impair >dobj [lemma='interaction'] Generic_eventte1: trigger: impairt>e1: trigger-arg-path: impair nn [lemma='ra'] FamilytLe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:FamilytSe1: trigger-arg-path: impair dobj Generic_eventtHe1: trigger-arg-path: Negative_regulation >dobj controlled:Generic_eventt]e1: trigger-arg-path: lemmatizedTrigger=impair:Negative_regulation dobjt0e1: args2Role-mention-ngram: CONTROLLER competest'e2: ents2Label-mention-ngram: DC pockettee2: trigger-arg-path: Positive_regulation nn [lemma='nrf2'] controllert]e2: trigger-arg-path: lemmatizedTrigger=cause nsubj Negative_regulationt&e1: args2Role-mention-ngram: DC pockett?e2: trigger-arg-path: causing:Positive_regulation nsubj [lemma='p62'] controlledtme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p62'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nn Gene_or_gene_producttFe2: trigger-arg-path: causing:Positive_regulation nn controllert+e1: ents2Label-mention-ngram: competes withthe2: trigger-arg-path: lemmatizedTrigger=cause nsubj controlled:Negative_regulationt(e2: ents2Label-mention-ngram: pocket andt&e2: ents2Label-mention-ngram: competest&e1: args2Role-mention-ngram: the Keap1t9e2: ents2Label-mention-ngram: inhibits the ubiquitinationtVe2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nn controllert3e1: ents2Label-mention-ngram: the ubiquitination oftRe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p62'] controllert e1: ents2Label-mention-ngram: DCtze2: trigger-arg-path: Positive_regulation nn [lemma='nrf2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=cause nsubj [lemma='p62'] Negative_regulationt[e2: trigger-arg-path: causing:Positive_regulation nn controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: binding to thet2e1: ents2Label-mention-ngram: SHARED competes withtYe2: trigger-arg-path: Positive_regulation nsubj Negative_regulationtGe2: trigger-arg-path: causing nn controller:Gene_or_gene_producttXe2: trigger-arg-path: causing nsubj controlled:Negative_regulationt3e2: ents2Label-mention-ngram: the ubiquitination oft'e1: ents2Label-mention-ngram: motif fort'e1: ents2Label-mention-ngram: of Nrf2 ,t%e1: ents2Label-mention-ngram: causingtme2: trigger-arg-path: causing:Positive_regulation nn [lemma='nrf2'] controllerte2: trigger: causingt+e1: ents2Label-mention-ngram: DC pocket andt?e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj [lemma='p62'] controlled:Negative_regulationt/e1: ents2Label-mention-ngram: motif for bindingt%e1: args2Role-mention-ngram: competest&e1: args2Role-mention-ngram: DLG motift'e1: ents2Label-mention-ngram: the Keap1t-e1: ents2Label-mention-ngram: SHARED competestie2: trigger-arg-path: lemmatizedTrigger=cause nn [lemma='nrf2'] controllert5e1: args2Role-mention-ngram: CONTROLLER competes withtOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p62'] controllert$e2: args2Role-mention-ngram: causingt?e2: trigger-arg-path: lemmatizedTrigger=cause nsubj [lemma='p62'] controlled:Negative_regulationt$e2: ents2Label-mention-ngram: pockettxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p62'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: DLG motif fortde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p62'] controller:Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=cause nn controllert0e1: ents2Label-mention-ngram: the ubiquitinationt)e1: ents2Label-mention-ngram: for bindingt,e2: ents2Label-mention-ngram: for binding tot#e1: args2Role-mention-ngram: pockett~e2: trigger-arg-path: lemmatizedTrigger=cause nn [lemma='nrf2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: causing nsubj [lemma='p62'] controlledt e2: ents2Label-mention-ngram: DCt,e1: ents2Label-mention-ngram: causing SHAREDt&e1: ents2Label-mention-ngram: competest!e2: ents2Label-mention-ngram: DLGt,e2: ents2Label-mention-ngram: binding to thet|e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj controlled:Negative_regulationt6e2: ents2Label-mention-ngram: ubiquitination of SHAREDte1: args2Role-mention-ngram: DCt'e1: ents2Label-mention-ngram: DLG motift)e1: args2Role-mention-ngram: the Keap1 DCt#e1: ents2Label-mention-ngram: motift(e1: ents2Label-mention-ngram: pocket andt/e1: ents2Label-mention-ngram: competes with thet"e1: args2Role-mention-ngram: motift.e2: ents2Label-mention-ngram: SHARED , causingt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='p62'] controlled:Negative_regulationt*e1: args2Role-mention-ngram: the DLG motift?e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj [lemma='p62'] controlledt?e2: trigger-arg-path: causing:Positive_regulation nn [lemma='nrf2'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: with the DLGt?e2: trigger-arg-path: causing:Positive_regulation nsubj [lemma='p62'] Negative_regulationt1e2: args2Role-mention-ngram: , causing CONTROLLERt,e1: ents2Label-mention-ngram: ubiquitinationt'e1: ents2Label-mention-ngram: DC pockettde2: trigger-arg-path: Positive_regulation nsubj controlled:Negative_regulationt*e1: ents2Label-mention-ngram: to the Keap1tPe2: trigger-arg-path: causing:Positive_regulation nn Gene_or_gene_producttMe2: trigger-arg-path: causing nsubj Negative_regulationtge1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p62'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: , causingtSe2: trigger-arg-path: Positive_regulation nn controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: to the Keap1t%e1: ents2Label-mention-ngram: of Nrf2t1e2: args2Role-mention-ngram: CONTROLLED , causingt'e2: ents2Label-mention-ngram: , causingt/e1: ents2Label-mention-ngram: ubiquitination oftse2: trigger-arg-path: lemmatizedTrigger=cause nn [lemma='nrf2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nn [lemma='nrf2'] controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: Nrf2t'e1: args2Role-mention-ngram: pocket andtne2: trigger-arg-path: causing nn [lemma='nrf2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: causing nsubj [lemma='p62'] Negative_regulationtoe2: trigger-arg-path: Positive_regulation nn [lemma='nrf2'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: the ubiquitinationtWe2: trigger-arg-path: lemmatizedTrigger=cause nn controller:Gene_or_gene_productt\e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='p62'] Gene_or_gene_productt(e1: args2Role-mention-ngram: for bindingt*e1: args2Role-mention-ngram: competes witht,e1: args2Role-mention-ngram: Keap1 DC pockett/e2: ents2Label-mention-ngram: motif for bindingt>e2: trigger-arg-path: Positive_regulation nn controllert.e1: ents2Label-mention-ngram: , causing SHAREDtTe2: trigger-arg-path: lemmatizedTrigger=cause nsubj controlledt e1: args2Role-mention-ngram: DLGt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='p62'] controller:Gene_or_gene_producttSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='p62'] Gene_or_gene_productt?e2: trigger-arg-path: causing:Positive_regulation nsubj [lemma='p62'] controlled:Negative_regulationt#e2: ents2Label-mention-ngram: motift+e1: ents2Label-mention-ngram: DLG motif fortYe2: trigger-arg-path: causing nn [lemma='nrf2'] controllertDe2: trigger-arg-path: causing nsubj controlledt+e1: args2Role-mention-ngram: for binding totXe2: trigger-arg-path: causing:Positive_regulation nsubj controlledt%e1: args2Role-mention-ngram: Keap1 DCtqe2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj Negative_regulationt+e2: ents2Label-mention-ngram: the DLG motift:e2: ents2Label-mention-ngram: causing GENE_OR_GENE_PRODUCTtYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='p62'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: ubiquitination of Nrf2t&e2: ents2Label-mention-ngram: Keap1 DCt&e1: ents2Label-mention-ngram: Keap1 DCt*e1: args2Role-mention-ngram: DC pocket andt9e1: ents2Label-mention-ngram: inhibits the ubiquitinationt/e2: ents2Label-mention-ngram: competes with thet?e2: trigger-arg-path: Positive_regulation nsubj [lemma='p62'] controlledtIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='p62'] controllert1e1: ents2Label-mention-ngram: pocket and inhibitsthe2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj controlledt$e1: ents2Label-mention-ngram: Nrf2 ,t-e2: ents2Label-mention-ngram: Keap1 DC pockett+e1: args2Role-mention-ngram: binding to thetce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='p62'] controllert'e1: ents2Label-mention-ngram: , causingt*e1: ents2Label-mention-ngram: the Keap1 DCt.e1: args2Role-mention-ngram: motif for bindingt/e2: ents2Label-mention-ngram: ubiquitination oft?e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nn [lemma='nrf2'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: competes withtnn [lemma='nrf2'] controllert'e2: ents2Label-mention-ngram: motif fort2e2: ents2Label-mention-ngram: SHARED competes withtke2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nn controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: the Keap1 DCt*e1: ents2Label-mention-ngram: with the DLGt*e2: ents2Label-mention-ngram: with the DLGt>e1: trigger-arg-path: inhibits >nsubj [lemma='p62'] controllert+e2: ents2Label-mention-ngram: DC pocket andt+e1: ents2Label-mention-ngram: the DLG motiftce2: trigger-arg-path: causing nn [lemma='nrf2'] Gene_or_gene_productt.e1: args2Role-mention-ngram: competes with thetSe1: trigger-arg-path: inhibits >nsubj [lemma='p62'] controller:Gene_or_gene_producttPe2: trigger-arg-path: Positive_regulation nsubj controlledt,e1: ents2Label-mention-ngram: Nrf2 , causingt?trigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj [lemma='ubiquitination'] >prep_of [lemma='stabilization'] >amod [lemma='cause'] e2:causing:Positive_regulationtHe1: trigger-arg-path: inhibits >nsubj [lemma='p62'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=cause:Positive_regulation nsubj [lemma='p62'] Negative_regulationt-e2: ents2Label-mention-ngram: SHARED competestLe2: trigger-arg-path: lemmatizedTrigger=cause nn Gene_or_gene_productt/e2: args2Role-mention-ngram: causing CONTROLLERt?e2: trigger-arg-path: lemmatizedTrigger=cause nsubj [lemma='p62'] controlledt'e2: ents2Label-mention-ngram: the Keap1t%e1: ents2Label-mention-ngram: the DLGtHe2: trigger-arg-path: Positive_regulation nn Gene_or_gene_productt2e2: trigger-arg-path: causing nn controllert$e1: args2Role-mention-ngram: the DLGt?e2: trigger-arg-path: causing nsubj [lemma='p62'] controlled:Negative_regulationt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='p62'] Negative_regulationt!e1: ents2Label-mention-ngram: DLGt,e1: ents2Label-mention-ngram: for binding totltrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj >prep_of >amod e2:causing:Positive_regulationt)e1: args2Role-mention-ngram: to the Keap1tle2: trigger-arg-path: causing:Positive_regulation nsubj controlled:Negative_regulationt1e2: ents2Label-mention-ngram: pocket and inhibitst$e1: ents2Label-mention-ngram: pockettae2: trigger-arg-path: causing:Positive_regulation nsubj Negative_regulationt&e1: args2Role-mention-ngram: motif fort*e1: args2Role-mention-ngram: DLG motif fort'e2: ents2Label-mention-ngram: DLG motiftwe2: trigger-arg-path: causing:Positive_regulation nn [lemma='nrf2'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: Keap1 DC pockett0e1: args2Role-mention-ngram: pocket and inhibitst'shortest-path: nn Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] Phosphorylationt@e1: trigger-arg-path: lemmatizedTrigger=lack >prep_of controlledt"e1: ents2Label-mention-ngram: lacktZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] controllertAe1: trigger-arg-path: lack >prep_of >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controller:Gene_or_gene_producttMe1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] Phosphorylationt>e1: trigger-arg-path: lack >prep_of controlled:Phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of >prep_by controllert~e1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] controlled:Phosphorylationtje1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] controlled:PhosphorylationtHe2: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] controllertMe1: trigger-arg-path: Negative_regulation >prep_of controlled:Phosphorylationt^e1: trigger-arg-path: lemmatizedTrigger=lack >prep_of >prep_by controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] Gene_or_gene_productt`e1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controllert\e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controllert7e1: trigger-arg-path: lack >prep_of >prep_by controllert|e1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of controlled:PhosphorylationtUe1: trigger-arg-path: lack:Negative_regulation >prep_of >prep_by Gene_or_gene_productt7e1: ents2Label-mention-ngram: of SHARED phosphorylationt\e1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] controlledt,e1: ents2Label-mention-ngram: lack of SHAREDt?e1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controller:Gene_or_gene_productt.e1: trigger-arg-path: lack >prep_of controlledt\e1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] Phosphorylationtoe1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controllertFe1: trigger-arg-path: Negative_regulation >prep_of >prep_by controllertge1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] controlled:PhosphorylationtBe1: trigger-arg-path: Negative_regulation >prep_of Phosphorylationtle1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] controlled:PhosphorylationtLe2: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] controllertre1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controllertxe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_producttWe1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] controlledtoe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttqe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controllertIe1: trigger-arg-path: lemmatizedTrigger=lack >prep_of >prep_by controllertGe1: trigger-arg-path: lack:Negative_regulation >prep_of Phosphorylationt%e1: ents2Label-mention-ngram: lack oftre1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of >prep_by controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: lack oftte1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controllert`e1: trigger-arg-path: lack:Negative_regulation >prep_of >prep_by controller:Gene_or_gene_producttje1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] Gene_or_gene_productt~trigger-to-trigger-path: e1:lack:Negative_regulation >prep_of [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt~e1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] Gene_or_gene_productt]e2: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] controller:Gene_or_gene_productte1: trigger: lacktRe2: trigger-arg-path: phosphorylation >prep_by [lemma='egfr'] Gene_or_gene_productt=e1: trigger-arg-path: Negative_regulation >prep_of controlledtKe1: trigger-arg-path: lack:Negative_regulation >prep_of >prep_by controllertae1: trigger-arg-path: lack:Negative_regulation >prep_of [lemma='phosphorylation'] PhosphorylationtEe1: trigger-arg-path: lemmatizedTrigger=lack >prep_of Phosphorylationt?e1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controller:Gene_or_gene_producttdtrigger-to-trigger-path: e1:lack:Negative_regulation >prep_of e2:phosphorylation:Positive_regulationtHe1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] controlledt!e1: args2Role-mention-ngram: lacktZe1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] controlledtTe1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of controlledtPe1: trigger-arg-path: Negative_regulation >prep_of >prep_by Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] Gene_or_gene_producttue1: trigger-arg-path: lack >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controller:Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] controller:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=lack >prep_of >prep_by Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=lack >prep_of controlled:PhosphorylationtRe1: trigger-arg-path: lack:Negative_regulation >prep_of controlled:Phosphorylationt-e1: args2Role-mention-ngram: of CONTROLLED byt[e1: trigger-arg-path: Negative_regulation >prep_of >prep_by controller:Gene_or_gene_producttVe2: trigger-arg-path: Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of >prep_by Gene_or_gene_producttye1: trigger-arg-path: Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] Gene_or_gene_producttfe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='egfr'] Gene_or_gene_producttLe1: trigger-arg-path: lack >prep_of >prep_by controller:Gene_or_gene_producttBe1: trigger-arg-path: lack:Negative_regulation >prep_of controlledt3e1: trigger-arg-path: lack >prep_of Phosphorylationt_e1: trigger-arg-path: lemmatizedTrigger=lack >prep_of [lemma='phosphorylation'] Phosphorylationtne1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=lack:Negative_regulation >prep_of [lemma='phosphorylation'] >prep_by [lemma='egfr'] controllert/e1: args2Role-mention-ngram: lack of CONTROLLEDt1e2: ents2Label-mention-ngram: the negative SHAREDtte1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_to Gene_or_gene_productt-e2: ents2Label-mention-ngram: to the negativet5e2: ents2Label-mention-ngram: SHARED regulator FAMILYt?e1: trigger-arg-path: Recruitment >prep_of Gene_or_gene_producttEe1: trigger-arg-path: Recruitment >prep_of theme:Gene_or_gene_producttbe1: trigger-arg-path: Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] Gene_or_gene_producttPe1: trigger-arg-path: Recruitment:Binding >prep_of >prep_to Gene_or_gene_productt_e1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] themet.e2: ents2Label-mention-ngram: SHARED regulatortMe1: trigger-arg-path: Recruitment:Binding >prep_of theme:Gene_or_gene_producttWe1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] Gene_or_gene_producttUe1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] theme:Gene_or_gene_productthe1: trigger-arg-path: Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] theme:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] Gene_or_gene_productt/e2: args2Role-mention-ngram: the negative THEMEtSe2: trigger-arg-path: Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] themetWe1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] themet+e1: args2Role-mention-ngram: Recruitment oftZe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] themet,e2: args2Role-mention-ngram: THEME regulatortVe1: trigger-arg-path: Recruitment:Binding >prep_of >prep_to theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] themetSe1: trigger-arg-path: Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] themetae1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_to themetZe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_to Gene_or_gene_productt5e2: args2Role-mention-ngram: negative THEME regulatorthe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_to theme:Gene_or_gene_productt^trigger-to-trigger-path: e1:Recruitment:Binding >prep_of >prep_to >prep_via e2:binding:Bindingt+e2: args2Role-mention-ngram: negative THEMEte1: trigger: Recruitmenttbe2: trigger-arg-path: binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] Gene_or_gene_productt8e1: trigger-arg-path: Recruitment:Binding >prep_of themetEe2: trigger-arg-path: binding >prep_to >nn theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] themetRe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] themetbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='suppressor'] >nn [lemma='GLI'] themetne1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] Gene_or_gene_productt,e2: args2Role-mention-ngram: to the negativet9e1: trigger-arg-path: Recruitment >prep_of >prep_to themet0e1: trigger-arg-path: Recruitment >prep_of themet)e1: ents2Label-mention-ngram: Recruitmentt+e2: args2Role-mention-ngram: binding to thet8e2: trigger-arg-path: binding:Binding >prep_to >nn themetfe1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] Gene_or_gene_producttje2: trigger-arg-path: binding:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='suppressor'] >nn [lemma='GLI'] Gene_or_gene_productthe2: trigger-arg-path: Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_to themet1e1: args2Role-mention-ngram: Recruitment of THEMEt[e2: trigger-arg-path: binding:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] themetNe1: trigger-arg-path: Recruitment >prep_of >prep_to theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: negative SHAREDt]e1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Recruitment:Binding >prep_of [lemma='sap18'] themet,e1: ents2Label-mention-ngram: Recruitment oftGe1: trigger-arg-path: Recruitment:Binding >prep_of Gene_or_gene_productt!interceding-tokens-full-span: viat?e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] theme:Gene_or_gene_productt@e1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] themet0e2: trigger-arg-path: binding >prep_to >nn themetprep_of [lemma='sap18'] themet,e2: args2Role-mention-ngram: regulator THEMEt(e1: args2Role-mention-ngram: Recruitmenttqe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] themetHe1: trigger-arg-path: Recruitment >prep_of >prep_to Gene_or_gene_producttSe2: trigger-arg-path: binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] themet`e1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_to theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_of [lemma='sap18'] Gene_or_gene_productt2e2: args2Role-mention-ngram: THEME regulator THEMEtOe1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT tot?e2: trigger-arg-path: binding >prep_to >nn Gene_or_gene_producttpe2: trigger-arg-path: binding:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] theme:Gene_or_gene_producttle1: trigger-arg-path: Recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] theme:Gene_or_gene_producttAe1: ents2Label-mention-ngram: Recruitment of GENE_OR_GENE_PRODUCTtye2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] theme:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='suppressor'] >nn [lemma='GLI'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='sap18'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_of [lemma='sap18'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] >prep_to [lemma='GLI'] Gene_or_gene_producttprep_of [lemma='sap18'] >prep_to [lemma='GLI'] >prep_via [lemma='bind'] e2:binding:BindingtMe2: trigger-arg-path: binding:Binding >prep_to >nn theme:Gene_or_gene_producttGe2: trigger-arg-path: binding:Binding >prep_to >nn Gene_or_gene_producttAe1: trigger-arg-path: Recruitment:Binding >prep_of >prep_to themetbe2: trigger-arg-path: Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] theme:Gene_or_gene_productthe2: trigger-arg-path: binding >prep_to [lemma='suppressor'] >nn [lemma='GLI'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='sap18'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >dobj [lemma='pi3k'] themetre1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by controller:Gene_or_gene_productt^e2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:FamilytMe2: trigger-arg-path: Binding >dobj [lemma='pi3k'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themetGe2: trigger-arg-path: Binding >dobj [lemma='pi3k'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: , bindtce1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by [lemma='IR'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: phosphorylated by IRtLe2: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] Gene_or_gene_producttJe2: trigger-arg-path: bind >dobj [lemma='pi3k'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: phosphorylated bytSe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by [lemma='IR'] controllertSe1: trigger-arg-path: phosphorylated:Positive_regulation nn Phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by controllertGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] themete1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by [lemma='IR'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: whent^e1: trigger-arg-path: phosphorylated nn [lemma='docking'] controlledtPe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn PhosphorylationtOe1: trigger-arg-path: Positive_regulation nn controlled:PhosphorylationtYe1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by [lemma='IR'] controllert_e1: trigger-arg-path: Positive_regulation >prep_by [lemma='IR'] controller:Gene_or_gene_producttre1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='docking'] controlledt0e2: args2Role-mention-ngram: when phosphorylatedtLe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn theme:Familythe1: trigger-arg-path: Positive_regulation nn [lemma='docking'] PhosphorylationtRe2: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='docking'] Familyt+e2: args2Role-mention-ngram: phosphorylatedtne1: trigger-arg-path: phosphorylated nn [lemma='docking'] controlled:PhosphorylationtVe2: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt5e2: trigger-arg-path: bind >dobj [lemma='pi3k'] themet-e2: args2Role-mention-ngram: THEME proteins ,tOe1: trigger-arg-path: phosphorylated >prep_by [lemma='IR'] Gene_or_gene_producttRe2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themetBe1: trigger-arg-path: phosphorylated >prep_by Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by [lemma='IR'] controller:Gene_or_gene_producttYe2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt!e2: args2Role-mention-ngram: IR ,tVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: proteins , whent^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3k'] Gene_or_gene_productt8e1: trigger-arg-path: phosphorylated >prep_by controllertce1: trigger-arg-path: Positive_regulation nn [lemma='docking'] controlledtte1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='docking'] Phosphorylationt/e2: trigger-arg-path: Binding >nsubj >nn FamilytTe1: trigger-arg-path: Positive_regulation >prep_by [lemma='IR'] Gene_or_gene_productt^e1: trigger-arg-path: phosphorylated:Positive_regulation nn controlled:Phosphorylationt>e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn FamilytFe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >nn FamilytBe2: ents2Label-mention-ngram: bind preferably GENE_OR_GENE_PRODUCTtje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by [lemma='IR'] controllertae1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: , bindt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controlledt3e2: ents2Label-mention-ngram: , when phosphorylatedtKe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controlledt,e2: args2Role-mention-ngram: proteins , whent"e2: args2Role-mention-ngram: by IRt#e2: ents2Label-mention-ngram: by IRte1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='docking'] controlled:Phosphorylationt/e2: ents2Label-mention-ngram: SHARED proteins ,t e2: ents2Label-mention-ngram: IRt5e2: trigger-arg-path: Binding >nsubj >nn theme:Familyt+e2: trigger-arg-path: bind >nsubj >nn themetae2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='docking'] themet3e2: trigger-arg-path: bind:Binding >nsubj >nn themetOe2: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] themet3e2: args2Role-mention-ngram: when phosphorylated byt?e1: trigger-arg-path: Positive_regulation nn controlledtZe1: trigger-arg-path: phosphorylated >prep_by [lemma='IR'] controller:Gene_or_gene_producttJe1: trigger-arg-path: phosphorylated nn controlled:Phosphorylationt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controlled:Phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn Phosphorylationt:e2: trigger-arg-path: bind:Binding >nsubj >nn theme:Familyte2: args2Role-mention-ngram: IRt.e2: args2Role-mention-ngram: , bind preferablyt"e2: ents2Label-mention-ngram: whentIe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by controllert'e2: ents2Label-mention-ngram: IR , bindt&e2: args2Role-mention-ngram: IR , bindt2e2: args2Role-mention-ngram: bind preferably THEMEt2e2: trigger-arg-path: bind >nsubj >nn theme:Familyt-e2: args2Role-mention-ngram: preferably THEMEt^e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by controller:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >nn theme:Familytte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by [lemma='IR'] Gene_or_gene_producttwe1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='docking'] Phosphorylationt-e2: ents2Label-mention-ngram: bind preferablytJe1: trigger-arg-path: Positive_regulation >prep_by [lemma='IR'] controllertXe2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] Familytne1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by [lemma='IR'] controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: IR ,tce1: trigger-arg-path: phosphorylated nn [lemma='docking'] PhosphorylationtLe1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by controllert%e2: ents2Label-mention-ngram: by IR ,tPe2: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='docking'] FamilytMe1: trigger-arg-path: phosphorylated >prep_by controller:Gene_or_gene_producttEe1: trigger-arg-path: phosphorylated >prep_by [lemma='IR'] controllertoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='docking'] controlledtWe2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] themet$shortest-path: nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='docking'] controlled:Phosphorylationt/e2: ents2Label-mention-ngram: , bind preferablyt$e2: ents2Label-mention-ngram: , whent-e2: ents2Label-mention-ngram: SHARED proteinstoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controlled:Phosphorylationt1e2: ents2Label-mention-ngram: when phosphorylatedt,e2: args2Role-mention-ngram: bind preferablytVe1: trigger-arg-path: phosphorylated:Positive_regulation >prep_by Gene_or_gene_producttSe2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='docking'] Familyt\trigger-to-trigger-path: e1:phosphorylated:Positive_regulation nn Phosphorylationt(e2: ents2Label-mention-ngram: preferablyt4e2: trigger-arg-path: bind:Binding >nsubj >nn Familytge1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >prep_by Gene_or_gene_productt$e2: args2Role-mention-ngram: by IR ,t:e1: trigger-arg-path: phosphorylated nn controlledt'e2: args2Role-mention-ngram: preferablyt+e2: args2Role-mention-ngram: THEME proteinst?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='docking'] Phosphorylationt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >prep_by [lemma='IR'] Gene_or_gene_productt=e2: trigger-arg-path: bind:Binding >dobj [lemma='pi3k'] themet}trigger-to-trigger-path: e1:phosphorylated:Positive_regulation dobj [lemma='pi3k'] theme:Gene_or_gene_productt=e2: ents2Label-mention-ngram: preferably GENE_OR_GENE_PRODUCTtNe1: trigger-arg-path: phosphorylated:Positive_regulation nn controlledtje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] Familyt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3k'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: when phosphorylated bytse1: trigger-arg-path: Positive_regulation nn [lemma='docking'] controlled:Phosphorylationt?e1: trigger-arg-path: phosphorylated nn Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='docking'] controlledt#e2: args2Role-mention-ngram: , whentpe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='docking'] theme:Familyt2e2: args2Role-mention-ngram: , when phosphorylatedtOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3k'] themetDe2: trigger-arg-path: bind >dobj [lemma='pi3k'] Gene_or_gene_productt,e2: trigger-arg-path: bind >nsubj >nn Familyt1e2: args2Role-mention-ngram: phosphorylated by IRt?e1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='docking'] controlled:Phosphorylationt@e1: trigger-arg-path: inhibit >nsubj [lemma='mcp110'] controllert?e1: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlled:Generic_eventt'e1: ents2Label-mention-ngram: and Raf ,t'e1: args2Role-mention-ngram: well as attNe1: trigger-arg-path: inhibit:Negative_regulation >dobj >prep_of Generic_eventtIe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of controlledtae1: trigger-arg-path: Negative_regulation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: functionalt1e1: args2Role-mention-ngram: physical interactiontke1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj >prep_of controlled:Generic_eventt2e1: ents2Label-mention-ngram: least one functionaltEe1: trigger-arg-path: inhibit >dobj >prep_of controlled:Generic_eventt(e1: ents2Label-mention-ngram: well as att7e1: ents2Label-mention-ngram: functional consequence oftWe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of controlled:Generic_eventt(e1: args2Role-mention-ngram: can inhibitt#e1: ents2Label-mention-ngram: leastt4e1: args2Role-mention-ngram: interaction between Rastpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mcp110'] Gene_or_gene_productt!e1: args2Role-mention-ngram: , ast*e1: ents2Label-mention-ngram: at least onet?e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlled:Generic_eventtoe1: trigger-arg-path: Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlledt"e1: args2Role-mention-ngram: leastt%e1: ents2Label-mention-ngram: of thatt+e1: args2Role-mention-ngram: consequence oftctrigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj >prep_of e2:interaction:Generic_eventt0e1: args2Role-mention-ngram: consequence of thatt$e1: args2Role-mention-ngram: of thatt^e1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='mcp110'] Gene_or_gene_productt3e1: args2Role-mention-ngram: functional consequencet)e1: ents2Label-mention-ngram: between Rast`e2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlledtge1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: that CONTROLLEDtfe1: trigger-arg-path: inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] Generic_eventt1e1: ents2Label-mention-ngram: of that interactiont?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] Generic_eventt1e1: args2Role-mention-ngram: least one functionalt4e1: ents2Label-mention-ngram: functional consequencet]e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj >prep_of controlledt,e1: args2Role-mention-ngram: can inhibit thetze1: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] Generic_eventt}e1: trigger-arg-path: Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlled:Generic_eventt$e1: args2Role-mention-ngram: Ras andt9e1: args2Role-mention-ngram: physical interaction betweent)e1: ents2Label-mention-ngram: consequencet\e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mcp110'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: Ras and Raftqe1: trigger-arg-path: inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlled:Generic_eventtKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf'] themet&e1: args2Role-mention-ngram: , as wellt,e1: args2Role-mention-ngram: between Ras andtQe1: trigger-arg-path: Negative_regulation >dobj >prep_of controlled:Generic_eventt`e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj >prep_of Generic_eventt6e1: args2Role-mention-ngram: functional consequence oft e1: args2Role-mention-ngram: onetie1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: one functionalt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: the physical interactiontCe1: trigger-arg-path: Negative_regulation >dobj >prep_of controlledt&e1: args2Role-mention-ngram: least onet'e1: ents2Label-mention-ngram: , as wellt)e1: args2Role-mention-ngram: the physicaltTe1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='mcp110'] controllert"e1: ents2Label-mention-ngram: wellt(e1: args2Role-mention-ngram: between Rast$e1: args2Role-mention-ngram: and Raftre1: trigger-arg-path: Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] Generic_eventte1: args2Role-mention-ngram: ast.e1: ents2Label-mention-ngram: that interactiont)e1: ents2Label-mention-ngram: as at leasttxe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] Generic_eventt%e1: ents2Label-mention-ngram: well ast$e1: args2Role-mention-ngram: well ast%e1: args2Role-mention-ngram: physicalt%e1: ents2Label-mention-ngram: Ras andtZe2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: physicalt(e1: args2Role-mention-ngram: Ras and Raft5e1: args2Role-mention-ngram: the physical interactiont:e1: trigger-arg-path: inhibit >dobj >prep_of Generic_eventt-e1: ents2Label-mention-ngram: can inhibit thet'e1: args2Role-mention-ngram: as well ast e1: ents2Label-mention-ngram: ast(e1: args2Role-mention-ngram: consequencetYe1: trigger-arg-path: inhibit:Negative_regulation >dobj >prep_of controlled:Generic_eventt5e1: ents2Label-mention-ngram: interaction between Rast%e1: args2Role-mention-ngram: Raf , ast(e1: ents2Label-mention-ngram: as well astJe1: trigger-arg-path: inhibit >nsubj [lemma='mcp110'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: and Raftce1: trigger-arg-path: inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlledt3e1: args2Role-mention-ngram: CONTROLLER can inhibittKe1: trigger-arg-path: inhibit:Negative_regulation >dobj >prep_of controlledt&e1: ents2Label-mention-ngram: Raf , ast*e1: ents2Label-mention-ngram: the physicalt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can inhibitt&e1: args2Role-mention-ngram: and Raf ,tUe1: trigger-arg-path: inhibit >nsubj [lemma='mcp110'] controller:Gene_or_gene_producttbshortest-path: dobj [lemma='consequence'] >prep_of [lemma='interaction']t"e1: ents2Label-mention-ngram: , ast2e1: ents2Label-mention-ngram: inhibit the physicalt-e1: ents2Label-mention-ngram: between Ras andtue1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlledt,e1: ents2Label-mention-ngram: one functionaltVe1: trigger-arg-path: Negative_regulation >nsubj [lemma='mcp110'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: least onet"e1: args2Role-mention-ngram: as attLe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of Generic_eventt7e1: args2Role-mention-ngram: one functional consequencet(e1: args2Role-mention-ngram: as at leastt%e1: args2Role-mention-ngram: at leasttCe2: trigger-arg-path: interaction >prep_between [lemma='raf'] themet#e1: ents2Label-mention-ngram: as att,e1: ents2Label-mention-ngram: consequence oft!e1: ents2Label-mention-ngram: onetwe1: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlledt%e1: ents2Label-mention-ngram: as wellt$e1: args2Role-mention-ngram: as welltLe1: trigger-arg-path: Negative_regulation >nsubj [lemma='mcp110'] controllert7e1: trigger-arg-path: inhibit >dobj >prep_of controlledtfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mcp110'] controllert&e1: ents2Label-mention-ngram: at leastt!e1: args2Role-mention-ngram: thatt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] controlled:Generic_eventtRe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mcp110'] controllert:e1: ents2Label-mention-ngram: physical interaction betweent8e1: ents2Label-mention-ngram: one functional consequencet2e1: ents2Label-mention-ngram: physical interactiont1e1: args2Role-mention-ngram: inhibit the physicalt)e1: ents2Label-mention-ngram: can inhibitt!e1: args2Role-mention-ngram: wellt1e1: ents2Label-mention-ngram: consequence of thatt)e1: args2Role-mention-ngram: at least onet(e1: ents2Label-mention-ngram: functionalt/e1: args2Role-mention-ngram: of that CONTROLLEDtFe1: trigger-arg-path: Negative_regulation >dobj >prep_of Generic_eventtRe2: trigger-arg-path: interaction >prep_between [lemma='raf'] Gene_or_gene_producttXe2: trigger-arg-path: interaction >prep_between [lemma='raf'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:inhibit:Negative_regulation >dobj [lemma='consequence'] >prep_of [lemma='interaction'] e2:interaction:Generic_eventt`e1: trigger-arg-path: phosphorylates >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controllert2e2: ents2Label-mention-ngram: , phosphorylates thet6e2: ents2Label-mention-ngram: phosphorylates the tumort(e2: ents2Label-mention-ngram: one of thetce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt:e1: ents2Label-mention-ngram: progression , phosphorylatest"e2: ents2Label-mention-ngram: T205tee1: trigger-arg-path: Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controllertqe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controllert)e1: ents2Label-mention-ngram: at the T205t%e2: ents2Label-mention-ngram: drivingt1e1: ents2Label-mention-ngram: signaling cascade ,t'e1: ents2Label-mention-ngram: cascade ,t"e2: ents2Label-mention-ngram: PDACt0e2: ents2Label-mention-ngram: driving forces fortze1: trigger-arg-path: Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: PDAC progressiont*e1: ents2Label-mention-ngram: of the majortte1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controllert+e2: ents2Label-mention-ngram: major drivingt)e2: ents2Label-mention-ngram: progressiont.e2: ents2Label-mention-ngram: tumor suppressort0e2: ents2Label-mention-ngram: PDAC progression ,tue1: trigger-arg-path: phosphorylates >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: signaling cascade ,t(e1: ents2Label-mention-ngram: suppressort$e2: ents2Label-mention-ngram: one oft9e1: args2Role-mention-ngram: CONTROLLER signaling cascadet0e2: ents2Label-mention-ngram: phosphorylates thet'e2: ents2Label-mention-ngram: the tumort%e1: ents2Label-mention-ngram: drivingt$e1: args2Role-mention-ngram: drivingt2e2: ents2Label-mention-ngram: for PDAC progressiont2e2: ents2Label-mention-ngram: suppressor SHARED att.e1: ents2Label-mention-ngram: SHARED signalingt#e1: args2Role-mention-ngram: one oft:e1: trigger-arg-path: phosphorylates >nsubj >nn controllert!e2: args2Role-mention-ngram: sitet(e1: ents2Label-mention-ngram: one of thet+e1: args2Role-mention-ngram: driving forcest2e1: ents2Label-mention-ngram: major driving forcest+e2: ents2Label-mention-ngram: the T205 sitet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: forces for PDACt1e2: ents2Label-mention-ngram: signaling cascade ,t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controllert%e1: args2Role-mention-ngram: for PDACt/e2: ents2Label-mention-ngram: suppressor SHAREDt2e1: ents2Label-mention-ngram: , phosphorylates thetNe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn controllert+e1: ents2Label-mention-ngram: SHARED at thet*e1: args2Role-mention-ngram: progression ,t#e1: ents2Label-mention-ngram: tumort/e2: ents2Label-mention-ngram: signaling cascadetOe1: trigger-arg-path: phosphorylates >nsubj >nn controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: tumor suppressort/e2: ents2Label-mention-ngram: the major drivingt(e2: ents2Label-mention-ngram: forces fort#e2: ents2Label-mention-ngram: tumort1e2: ents2Label-mention-ngram: and promotes SHAREDt&e2: ents2Label-mention-ngram: for PDACt'e1: args2Role-mention-ngram: one of thet)e1: ents2Label-mention-ngram: progressiont!e1: args2Role-mention-ngram: PDACt&e1: ents2Label-mention-ngram: for PDACt.e1: args2Role-mention-ngram: signaling cascadet*e1: args2Role-mention-ngram: cascade , onet*e2: ents2Label-mention-ngram: of the majort.e1: args2Role-mention-ngram: the major drivingt+e1: ents2Label-mention-ngram: major drivingt:e2: ents2Label-mention-ngram: progression , phosphorylatest?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] Gene_or_gene_productt)e1: args2Role-mention-ngram: , CONTROLLEDt6e1: ents2Label-mention-ngram: SHARED signaling cascadet+e2: ents2Label-mention-ngram: T205 site andt1e1: args2Role-mention-ngram: major driving forcest"e1: args2Role-mention-ngram: , onet'e2: ents2Label-mention-ngram: the majort%e2: args2Role-mention-ngram: site andt2e1: ents2Label-mention-ngram: for PDAC progressiont2e1: ents2Label-mention-ngram: suppressor SHARED att'e1: ents2Label-mention-ngram: the tumort#e1: ents2Label-mention-ngram: , onet&e1: args2Role-mention-ngram: the majortnn [lemma='signaling']t2e2: ents2Label-mention-ngram: the tumor suppressort5e1: ents2Label-mention-ngram: tumor suppressor SHAREDt%e1: args2Role-mention-ngram: , one oft+e2: ents2Label-mention-ngram: progression ,t?e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: the T205t$e1: ents2Label-mention-ngram: forcest.e1: ents2Label-mention-ngram: PDAC progressiont#e2: ents2Label-mention-ngram: , onet%e2: ents2Label-mention-ngram: cascadetztrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and [lemma='promote'] e2:promotes:Positive_regulationt,e1: ents2Label-mention-ngram: driving forcest#e1: ents2Label-mention-ngram: majort(e1: ents2Label-mention-ngram: forces fort&e1: ents2Label-mention-ngram: , one oft&e2: ents2Label-mention-ngram: , one oft(e1: args2Role-mention-ngram: progressiont+e2: ents2Label-mention-ngram: cascade , onet"e1: args2Role-mention-ngram: majort4e2: args2Role-mention-ngram: and promotes CONTROLLEDt&e2: ents2Label-mention-ngram: site andt/e1: args2Role-mention-ngram: PDAC progression ,t"e2: ents2Label-mention-ngram: sitet*e1: args2Role-mention-ngram: major drivingt/e1: args2Role-mention-ngram: driving forces fort1e1: args2Role-mention-ngram: for PDAC progressiont6e2: ents2Label-mention-ngram: SHARED signaling cascadet.e2: args2Role-mention-ngram: site and promotest.e2: ents2Label-mention-ngram: SHARED signalingt&e1: ents2Label-mention-ngram: the T205t5e2: ents2Label-mention-ngram: tumor suppressor SHAREDt&e1: args2Role-mention-ngram: cascade ,t,e2: ents2Label-mention-ngram: driving forcest6e1: ents2Label-mention-ngram: phosphorylates the tumortDe1: trigger-arg-path: phosphorylates >nsubj >nn Gene_or_gene_producttje1: trigger-arg-path: phosphorylates >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] Gene_or_gene_productt'e1: args2Role-mention-ngram: forces fort5e1: args2Role-mention-ngram: progression , CONTROLLEDt2e2: ents2Label-mention-ngram: major driving forcest'e2: ents2Label-mention-ngram: cascade ,t/e1: ents2Label-mention-ngram: suppressor SHAREDt,e1: args2Role-mention-ngram: forces for PDACt,e2: args2Role-mention-ngram: CONTROLLER sitet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: PDAC progressiont$e2: ents2Label-mention-ngram: forcest-e2: ents2Label-mention-ngram: forces for PDACt/e1: ents2Label-mention-ngram: signaling cascadet'e1: ents2Label-mention-ngram: the majorthtrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and e2:promotes:Positive_regulationt#e1: args2Role-mention-ngram: forcest2e1: ents2Label-mention-ngram: the tumor suppressort)e2: ents2Label-mention-ngram: at the T205t0e1: ents2Label-mention-ngram: PDAC progression ,t"e1: ents2Label-mention-ngram: T205t0e1: ents2Label-mention-ngram: driving forces fort/e2: ents2Label-mention-ngram: site and promotest)e1: args2Role-mention-ngram: of the majort'e2: ents2Label-mention-ngram: T205 sitet#e2: ents2Label-mention-ngram: majort+e1: ents2Label-mention-ngram: progression ,t/e1: ents2Label-mention-ngram: the major drivingt0e2: args2Role-mention-ngram: CONTROLLER site andtXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn Gene_or_gene_productt+e1: ents2Label-mention-ngram: cascade , onet$e1: ents2Label-mention-ngram: one oft~e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] Gene_or_gene_producttoe1: trigger-arg-path: Positive_regulation >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='cascade'] >nn [lemma='kras-mapk'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: suppressort"e1: ents2Label-mention-ngram: PDACt)interceding-token ngrams: quiescent cellstEe2: trigger-arg-path: Negative_regulation nsubj Generic_eventtje2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj controller:Generic_eventt-e2: args2Role-mention-ngram: serve to preventtQe1: trigger-arg-path: binding:Binding >prep_to [lemma='Ksr'] Gene_or_gene_productt1interceding-token ngrams: limited kinase activitytBe1: trigger-arg-path: binding:Binding >prep_to [lemma='Ksr'] themetke2: trigger-arg-path: Negative_regulation nsubj [lemma='association'] Generic_eventtPe2: trigger-arg-path: Negative_regulation nsubj controller:Generic_eventt,interceding-token ngrams: in quiescent cellst&e2: args2Role-mention-ngram: B-Raf maytDe2: trigger-arg-path: prevent nsubj controller:Generic_eventt,e2: args2Role-mention-ngram: B-Raf may servet/e2: ents2Label-mention-ngram: to prevent SHAREDt&e2: ents2Label-mention-ngram: serve tot!e2: ents2Label-mention-ngram: Ksrt)e2: ents2Label-mention-ngram: of Ksr withtBe2: trigger-arg-path: Negative_regulation nsubj controllertOe1: trigger-arg-path: binding >prep_to [lemma='Ksr'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: B-RaftLe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='Ksr'] themet[e1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='Ksr'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='Ksr'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf'] theme:Gene_or_gene_productt$e2: ents2Label-mention-ngram: of KsrtKe2: trigger-arg-path: lemmatizedTrigger=prevent nsubj Generic_eventt#e2: ents2Label-mention-ngram: B-Raft~e2: trigger-arg-path: prevent:Negative_regulation nsubj [lemma='association'] controller:Generic_eventtWe1: trigger-arg-path: binding:Binding >prep_to [lemma='Ksr'] theme:Gene_or_gene_productt)interceding-token ngrams: induces limitedt=e1: trigger-arg-path: binding:Binding >nn [lemma='raf'] themetpe2: trigger-arg-path: prevent:Negative_regulation nsubj [lemma='association'] controllert5e1: trigger-arg-path: binding >nn [lemma='raf'] themetOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf'] themetMe2: trigger-arg-path: prevent:Negative_regulation nsubj Generic_eventt'e2: ents2Label-mention-ngram: may servet#e2: args2Role-mention-ngram: of Ksrt#interceding-token ngrams: quiescenttLe1: trigger-arg-path: binding:Binding >nn [lemma='raf'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: Ksr witht'interceding-token ngrams: activity , intGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf'] themet:e1: trigger-arg-path: Binding >prep_to [lemma='Ksr'] themet,e2: ents2Label-mention-ngram: association oft?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj [lemma='association'] controllert(e2: args2Role-mention-ngram: of Ksr witht-interceding-token ngrams: quiescent cells thet.e2: args2Role-mention-ngram: CONTROLLER of KsrtVe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='raf'] Gene_or_gene_productt&interceding-token ngrams: in quiescentt&e2: args2Role-mention-ngram: may servetHe2: trigger-arg-path: lemmatizedTrigger=prevent nsubj controllert"e2: args2Role-mention-ngram: servetJe1: trigger-arg-path: binding >nn [lemma='raf'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: preventt e2: args2Role-mention-ngram: KsrtVe2: trigger-arg-path: lemmatizedTrigger=prevent nsubj controller:Generic_eventt#e2: ents2Label-mention-ngram: servet9e2: trigger-arg-path: prevent nsubj Generic_eventtRe1: trigger-arg-path: binding:Binding >nn [lemma='raf'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:binding:Binding dobj [lemma='activity'] >prep_in [lemma='cell'] >rcmod [lemma='serve'] >xcomp [lemma='prevent'] e2:prevent:Negative_regulationtcinterceding-tokens-full-span: induces limited kinase activity , in quiescent cells the constitutivet|e2: trigger-arg-path: lemmatizedTrigger=prevent nsubj [lemma='association'] controller:Generic_eventt,e2: ents2Label-mention-ngram: Ksr with B-Raft_e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj Generic_eventt)interceding-token ngrams: kinase activityt?shortest-path: dobj [lemma='activity'] >prep_in [lemma='cell'] >rcmod [lemma='serve'] >nsubj [lemma='association']t#interceding-token ngrams: cells thet(e2: ents2Label-mention-ngram: with B-Raftce1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='Ksr'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj controllert$e2: args2Role-mention-ngram: preventt0interceding-token ngrams: cells the constitutivetse2: trigger-arg-path: prevent:Negative_regulation nsubj [lemma='association'] Generic_eventte2: trigger: preventt'e2: args2Role-mention-ngram: with B-RaftXe2: trigger-arg-path: prevent:Negative_regulation nsubj controller:Generic_eventt+interceding-token ngrams: kinase activity ,the2: trigger-arg-path: Negative_regulation nsubj [lemma='association'] controllert,e2: ents2Label-mention-ngram: prevent SHAREDt*e2: args2Role-mention-ngram: CONTROLLER oft?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj [lemma='association'] controller:Generic_eventt,e2: ents2Label-mention-ngram: with B-Raf mayt*e2: ents2Label-mention-ngram: may serve totIe1: trigger-arg-path: binding >prep_to [lemma='Ksr'] Gene_or_gene_producttDe1: trigger-arg-path: binding >nn [lemma='raf'] Gene_or_gene_productt\e2: trigger-arg-path: prevent nsubj [lemma='association'] controllert!interceding-token ngrams: limitedt+e2: args2Role-mention-ngram: Ksr with B-Raft0interceding-token ngrams: induces limited kinaset&interceding-token ngrams: constitutivet_e2: trigger-arg-path: prevent nsubj [lemma='association'] Generic_eventtie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='Ksr'] theme:Gene_or_gene_productt6e2: trigger-arg-path: prevent nsubj controllertntrigger-to-trigger-path: e1:binding:Binding dobj >prep_in >rcmod >xcomp e2:prevent:Negative_regulationt.e2: ents2Label-mention-ngram: serve to preventt/e2: args2Role-mention-ngram: prevent CONTROLLEDtTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='Ksr'] themet'e2: ents2Label-mention-ngram: B-Raf mayt2e2: args2Role-mention-ngram: to prevent CONTROLLEDtJe2: trigger-arg-path: prevent:Negative_regulation nsubj controllert(e2: ents2Label-mention-ngram: to preventt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation nsubj [lemma='association'] Generic_eventt%e2: args2Role-mention-ngram: serve tot(interceding-token ngrams: , in quiescenttqe2: trigger-arg-path: lemmatizedTrigger=prevent nsubj [lemma='association'] Generic_eventtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='raf'] theme:Gene_or_gene_productt*interceding-token ngrams: the constitutivetOe1: trigger-arg-path: Binding >prep_to [lemma='Ksr'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: with B-Raf mayt%e2: args2Role-mention-ngram: Ksr witht0e2: ents2Label-mention-ngram: association of Ksrt6shortest-path: dobj >prep_in >rcmod >nsubjtne2: trigger-arg-path: lemmatizedTrigger=prevent nsubj [lemma='association'] controllertIe1: trigger-arg-path: Binding >prep_to [lemma='Ksr'] Gene_or_gene_producttje2: trigger-arg-path: prevent nsubj [lemma='association'] controller:Generic_eventtve2: trigger-arg-path: Negative_regulation nsubj [lemma='association'] controller:Generic_eventt'e2: args2Role-mention-ngram: to preventt)e2: args2Role-mention-ngram: may serve tot4e2: ents2Label-mention-ngram: prevent SHARED bindingt:e1: trigger-arg-path: binding >prep_to [lemma='Ksr'] themet(interceding-token ngrams: limited kinaset-e2: ents2Label-mention-ngram: B-Raf may servet#interceding-token ngrams: GDP boundtPtrigger-to-trigger-path: e1:binds:Binding ccomp >dobj e2:binding:Bindingt]e2: trigger-arg-path: binding:Binding prep_with [lemma='gtp'] themetOe1: trigger-arg-path: Binding >nsubj [lemma='phlpp'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >nsubj [lemma='phlpp'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >nsubj [lemma='phlpp'] theme:Gene_or_gene_producttUe2: trigger-arg-path: binding prep_with [lemma='gtp'] themet#interceding-token ngrams: abrogatest(interceding-token ngrams: turn abrogatestFe2: trigger-arg-path: lemmatizedTrigger=binding prep_with themet~e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='gtp'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: binding witht#interceding-token ngrams: switchingt:e1: trigger-arg-path: Binding >nsubj [lemma='phlpp'] themetKe2: trigger-arg-path: binding:Binding prep_with Gene_or_gene_productt(interceding-token ngrams: GDP bound formt|e2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='gtp'] theme:Gene_or_gene_productt interceding-token ngrams: duringtprep_with themetinterceding-tokens-full-span: , which occurs during Ras switching from GTP bound form to GDP bound form , and in turn abrogatestGe1: trigger-arg-path: binds >nsubj [lemma='phlpp'] Gene_or_gene_productt,e1: args2Role-mention-ngram: nucleotide-freetle2: trigger-arg-path: binding:Binding prep_with [lemma='gtp'] Gene_or_gene_productt/e2: args2Role-mention-ngram: binding with THEMEt'interceding-token ngrams: bound form totde2: trigger-arg-path: binding prep_with [lemma='gtp'] Gene_or_gene_producttCe2: trigger-arg-path: binding prep_with Gene_or_gene_productt$interceding-token ngrams: during RastIe1: trigger-arg-path: Binding >nsubj [lemma='phlpp'] Gene_or_gene_productt interceding-token ngrams: and intde2: trigger-arg-path: Binding prep_with [lemma='gtp'] Gene_or_gene_productt!interceding-token ngrams: in turnt'interceding-token ngrams: Ras switchingt&interceding-token ngrams: to GDP boundtre2: trigger-arg-path: binding:Binding prep_with [lemma='gtp'] theme:Gene_or_gene_productt#interceding-token ngrams: GTP boundt!interceding-token ngrams: form tot$interceding-token ngrams: form , andtje2: trigger-arg-path: Binding prep_with [lemma='gtp'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: nucleotide-free THEMEt)e2: args2Role-mention-ngram: binding witht8e1: ents2Label-mention-ngram: the nucleotide-free SHAREDtNe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with themet'interceding-token ngrams: occurs duringt@e1: trigger-arg-path: binds:Binding >nsubj [lemma='phlpp'] themet1e1: ents2Label-mention-ngram: the nucleotide-freet7e1: trigger-arg-path: binds >prep_to [lemma='ra'] themet3e1: args2Role-mention-ngram: to the nucleotide-freetUe2: trigger-arg-path: lemmatizedTrigger=binding prep_with Gene_or_gene_productt.interceding-token ngrams: during Ras switchingtIe2: trigger-arg-path: binding prep_with theme:Gene_or_gene_productt&interceding-token ngrams: bound form ,t[e2: trigger-arg-path: lemmatizedTrigger=binding prep_with theme:Gene_or_gene_productt$interceding-token ngrams: bound formtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='phlpp'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:binds:Binding ccomp [lemma='abrogate'] >dobj [lemma='binding'] e2:binding:Bindingt,interceding-token ngrams: switching from GTPt+interceding-token ngrams: occurs during Rast(interceding-token ngrams: switching fromtge2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='gtp'] themet&interceding-token ngrams: which occurst@e1: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] Familyt(interceding-token ngrams: from GTP boundt4e1: ents2Label-mention-ngram: to the nucleotide-freet interceding-token ngrams: occurst^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='phlpp'] theme:Gene_or_gene_productt,interceding-token ngrams: Ras switching fromt0e1: args2Role-mention-ngram: the nucleotide-freet%interceding-token ngrams: and in turntje2: trigger-arg-path: binding prep_with [lemma='gtp'] theme:Gene_or_gene_productt?e1: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] themetinterceding-token ngrams: GDPt]e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with Gene_or_gene_producttinterceding-token ngrams: boundt4e2: trigger-arg-path: binding prep_with themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='phlpp'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='phlpp'] themet-e1: ents2Label-mention-ngram: nucleotide-freet8e1: trigger-arg-path: binds >prep_to [lemma='ra'] FamilytMe1: trigger-arg-path: binds >nsubj [lemma='phlpp'] theme:Gene_or_gene_productt}shortest-path: ccomp [lemma='abrogate'] >dobj [lemma='binding'] >nn [lemma='ra']toe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='gtp'] themet4e1: ents2Label-mention-ngram: nucleotide-free SHAREDt interceding-token ngrams: to GDPt-interceding-token ngrams: which occurs duringt%interceding-token ngrams: form to GDPt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='gtp'] theme:Gene_or_gene_producttinterceding-token ngrams: turnt8e1: trigger-arg-path: binds >nsubj [lemma='phlpp'] themetQe2: trigger-arg-path: binding:Binding prep_with theme:Gene_or_gene_productt>e1: trigger-arg-path: binds >prep_to [lemma='ra'] theme:Familytve2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='gtp'] Gene_or_gene_productt"interceding-token ngrams: , and intce2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with theme:Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED binding witht/e2: args2Role-mention-ngram: THEME binding withtXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='phlpp'] Gene_or_gene_productt6e1: args2Role-mention-ngram: the nucleotide-free THEMEt interceding-token ngrams: form ,t+interceding-token ngrams: in turn abrogatestFe1: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] theme:Familyt(interceding-token ngrams: GTP bound formt?e2: ents2Label-mention-ngram: binding with GENE_OR_GENE_PRODUCTt-shortest-path: ccomp >dobj >nnt(interceding-token ngrams: , which occurst"interceding-token ngrams: from GTPt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='phlpp'] Gene_or_gene_producttUe2: trigger-arg-path: Binding prep_with [lemma='gtp'] themetWe1: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] Gene_or_gene_producttHe1: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] themetDe1: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] themet!e2: ents2Label-mention-ngram: RastZe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] themetie2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlledtSe1: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] Gene_or_gene_productt(e2: args2Role-mention-ngram: , decreasedt_e2: trigger-arg-path: decreased >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlledt)e2: args2Role-mention-ngram: negative RastWtrigger-to-trigger-path: e1:interaction:Binding prep_between [lemma='rasgap'] Gene_or_gene_producttse2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlledtCe2: trigger-arg-path: decreased >dobj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlled:Gene_or_gene_productt_e1: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] Gene_or_gene_producttee1: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: decreased the kinasetUe1: trigger-arg-path: interaction >prep_between [lemma='rasgap'] Gene_or_gene_producttNe1: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] themetTe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj >prep_of Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttYe1: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: Ras regulator ,t-e2: ents2Label-mention-ngram: kinase activityt3e2: ents2Label-mention-ngram: regulator , decreasedt)e2: ents2Label-mention-ngram: regulator ,t*e2: args2Role-mention-ngram: Ras regulatort~e2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlled:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] themetse2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt(e2: args2Role-mention-ngram: regulator ,t e2: args2Role-mention-ngram: Rast-e2: ents2Label-mention-ngram: , decreased thet,e2: args2Role-mention-ngram: Ras regulator ,t^e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >prep_of controlledtte2: trigger-arg-path: decreased >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlled:Gene_or_gene_producttFe1: trigger-arg-path: interaction >prep_between [lemma='rasgap'] themet2e2: ents2Label-mention-ngram: decreased the kinasetJe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj >prep_of controlledtjtrigger-to-trigger-path: e1:interaction:Binding dobj >prep_of controlledtbe2: trigger-arg-path: decreased:Negative_activation >dobj >prep_of controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: , decreased thet0e2: ents2Label-mention-ngram: kinase activity oftXe2: trigger-arg-path: Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt+e2: ents2Label-mention-ngram: Ras regulatortie2: trigger-arg-path: decreased >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] Gene_or_gene_productt+e2: args2Role-mention-ngram: CONTROLLER , at/e2: args2Role-mention-ngram: kinase activity oftoe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] themetpe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlledtNe2: trigger-arg-path: decreased >dobj >prep_of controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: decreased thet]e1: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Negative_activation >dobj >prep_of Gene_or_gene_productt4e2: ents2Label-mention-ngram: negative Ras regulatortie1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] Gene_or_gene_productt[e1: trigger-arg-path: interaction >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt1e2: ents2Label-mention-ngram: the kinase activitytXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] themetoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] Gene_or_gene_producttWe1: trigger-arg-path: Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] Gene_or_gene_productt]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] Gene_or_gene_productt}e2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: , decreasedt+e2: ents2Label-mention-ngram: decreased thet?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlledt?e2: trigger-arg-path: decreased:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlled:Gene_or_gene_productt+e2: args2Role-mention-ngram: a negative Rast_e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj >prep_of controlled:Gene_or_gene_producttBe1: trigger-arg-path: Binding >prep_between [lemma='rasgap'] themetse2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] Gene_or_gene_productt9e2: trigger-arg-path: decreased >dobj >prep_of controlledtce1: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: negative RastWe2: trigger-arg-path: decreased:Negative_activation >dobj >prep_of Gene_or_gene_productt,e2: ents2Label-mention-ngram: a negative Rast?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >prep_of [lemma='aurora-a'] controlled:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: the kinase activitythe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >prep_of Gene_or_gene_producttPe1: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] themet2e2: args2Role-mention-ngram: regulator , decreasedt3e1: trigger-arg-path: induces >nsubj >nn controllertme2: trigger-arg-path: Positive_regulation prep_by [lemma='cdh1'] Gene_or_gene_producttge2: trigger-arg-path: ubiquitination:Positive_regulation prep_by controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by controllertxe2: trigger-arg-path: Positive_regulation prep_by [lemma='cdh1'] controller:Gene_or_gene_producttle1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controller:Familyt9e1: args2Role-mention-ngram: CONTROLLER signaling inducestie1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] Familyt?e2: trigger-arg-path: ubiquitination:Positive_regulation prep_by [lemma='cdh1'] controller:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn Familytqe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controller:Familytte1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controller:FamilytSe2: trigger-arg-path: ubiquitination prep_by controller:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] Familytctrigger-to-trigger-path: e1:induces:Positive_regulation >dobj e2:ubiquitination:Positive_regulationtee2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by controller:Gene_or_gene_producttse2: trigger-arg-path: ubiquitination prep_by [lemma='cdh1'] controller:Gene_or_gene_producttce2: trigger-arg-path: Positive_regulation prep_by [lemma='cdh1'] controllertee1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controllert.e1: args2Role-mention-ngram: signaling inducest\e2: trigger-arg-path: ubiquitination:Positive_regulation prep_by Gene_or_gene_producttRe2: trigger-arg-path: ubiquitination:Positive_regulation prep_by controllertre2: trigger-arg-path: ubiquitination:Positive_regulation prep_by [lemma='cdh1'] controllert]shortest-path: dobj [lemma='ubiquitination']t/e1: trigger-arg-path: induces >nsubj >nn Familyt`e1: trigger-arg-path: induces >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controller:FamilytYe1: trigger-arg-path: induces >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by [lemma='cdh1'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by [lemma='cdh1'] controllert6e1: ents2Label-mention-ngram: FAMILY signaling inducest^e2: trigger-arg-path: ubiquitination prep_by [lemma='cdh1'] controllertae1: trigger-arg-path: Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] Familytne2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controllert:e1: trigger-arg-path: induces >nsubj >nn controller:FamilytZe2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by [lemma='cdh1'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: signaling inducestTe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn FamilytHe2: trigger-arg-path: ubiquitination prep_by Gene_or_gene_productt>e2: trigger-arg-path: ubiquitination prep_by controllert2e1: args2Role-mention-ngram: signaling induces thet?e2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by [lemma='cdh1'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: induces the CONTROLLEDtUe1: trigger-arg-path: induces >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] FamilytGe1: trigger-arg-path: induces:Positive_regulation >nsubj >nn controllert3e1: ents2Label-mention-ngram: signaling induces thetXe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn controllertDe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controllert)e1: ents2Label-mention-ngram: induces thet8e1: ents2Label-mention-ngram: induces the ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by [lemma='cdh1'] controllertye2: trigger-arg-path: lemmatizedTrigger=ubiquitination:Positive_regulation prep_by controller:Gene_or_gene_producttme1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controllertPe2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by controllert|e2: trigger-arg-path: ubiquitination:Positive_regulation prep_by [lemma='cdh1'] Gene_or_gene_productthe2: trigger-arg-path: ubiquitination prep_by [lemma='cdh1'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn controller:Familyt|trigger-to-trigger-path: e1:induces:Positive_regulation >dobj [lemma='ubiquitination'] e2:ubiquitination:Positive_regulationtKe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controller:Familyt~e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] controllertfe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='signaling'] >nn [lemma='tgfbeta'] Familytze2: trigger-arg-path: lemmatizedTrigger=ubiquitination prep_by [lemma='cdh1'] Gene_or_gene_producttCe1: trigger-arg-path: induces:Positive_regulation >nsubj >nn FamilytNe1: trigger-arg-path: induces:Positive_regulation >nsubj >nn controller:Familyt6e1: ents2Label-mention-ngram: ubiquitination of SHAREDt(e1: args2Role-mention-ngram: induces thetPe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ir'] controllertae2: trigger-arg-path: blocked >agent [lemma='inhibitor'] >nn [lemma='erbb1'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: shown in Figuret#e2: ents2Label-mention-ngram: couldtNe1: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass controlledt^e2: trigger-arg-path: blocked:Positive_regulation nsubj controlled:Negative_regulationtTe2: trigger-arg-path: blocked nsubj [lemma='ir'] controlledt%e2: args2Role-mention-ngram: could bet?e2: trigger-arg-path: blocked nsubj Negative_regulationt*e2: args2Role-mention-ngram: be blocked bytze1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] PhosphorylationtSe2: trigger-arg-path: blocked:Positive_regulation nsubj Negative_regulationt]e2: trigger-arg-path: blocked nsubj [lemma='ir'] Negative_regulationt0e2: args2Role-mention-ngram: CONTROLLED shown intqe2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='ir'] Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtie2: trigger-arg-path: Positive_regulation nsubj [lemma='ir'] Negative_regulationt"e2: args2Role-mention-ngram: couldtZe2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj controlledtce2: trigger-arg-path: Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controllertVe2: trigger-arg-path: Positive_regulation nsubj controlled:Negative_regulationt|e2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='ir'] controlled:Negative_regulationtce2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj Negative_regulationt_e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass controlledt6e2: trigger-arg-path: blocked nsubj controlledtte1: trigger-arg-path: induced >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt(e2: ents2Label-mention-ngram: be blockedtxe2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='ir'] controlled:Negative_regulationt&e2: ents2Label-mention-ngram: could bet-e2: ents2Label-mention-ngram: in Figure couldt+e2: ents2Label-mention-ngram: be blocked byt'e2: args2Role-mention-ngram: be blockedtte2: trigger-arg-path: Positive_regulation nsubj [lemma='ir'] controlled:Negative_regulationtHe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ir'] controllert,e2: args2Role-mention-ngram: shown in Figuret?e1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass PhosphorylationtPe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass PhosphorylationtVe1: trigger-arg-path: Negative_regulation >ccomp >nsubjpass controlled:Phosphorylationt,e2: args2Role-mention-ngram: in Figure couldtJe2: trigger-arg-path: blocked nsubj controlled:Negative_regulationtxe1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlledt-e2: args2Role-mention-ngram: CONTROLLED showntZe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ir'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='ir'] controlled:Negative_regulationt?e1: trigger-arg-path: induced >ccomp >nsubjpass Phosphorylationtue2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] Gene_or_gene_productt}e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] Phosphorylationtle2: trigger-arg-path: blocked >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controller:Gene_or_gene_producttde1: trigger-arg-path: induced >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ir'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: Figure couldtKe1: trigger-arg-path: Negative_regulation >ccomp >nsubjpass Phosphorylationtie1: trigger-arg-path: induced >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] Phosphorylationthe2: trigger-arg-path: blocked:Positive_regulation nsubj [lemma='ir'] controlledtue1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlledt%e2: args2Role-mention-ngram: shown intae1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ir'] controllert?e1: trigger-arg-path: Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt?e2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controller:Gene_or_gene_productt:e2: ents2Label-mention-ngram: SHARED phosphorylation showntOe2: trigger-arg-path: lemmatizedTrigger=block nsubj Negative_regulationtve1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: could be blockedtoe1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass controlled:PhosphorylationtSe1: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass Phosphorylationtmtrigger-to-trigger-path: e1:induced:Negative_regulation >ccomp [lemma='block'] e2:blocked:Positive_regulationt^e1: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass controlled:Phosphorylationthe2: trigger-arg-path: blocked nsubj [lemma='ir'] controlled:Negative_regulationt3e2: ents2Label-mention-ngram: phosphorylation showntZe2: trigger-arg-path: lemmatizedTrigger=block nsubj controlled:Negative_regulationt-e2: ents2Label-mention-ngram: Figure could betue1: trigger-arg-path: Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] PhosphorylationtFe2: trigger-arg-path: lemmatizedTrigger=block nsubj controlledt?e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtke2: trigger-arg-path: blocked:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controllertWe2: trigger-arg-path: blocked >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controllertJe2: trigger-arg-path: blocked:Positive_regulation nsubj controlledtme2: trigger-arg-path: Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylation shown intxe2: trigger-arg-path: Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: Figuret]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass controlled:Phosphorylationt{e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controllertFe1: trigger-arg-path: Negative_regulation >ccomp >nsubjpass controlledtpe1: trigger-arg-path: Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlledt,e2: args2Role-mention-ngram: Figure could bet|e2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: shown int?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: Figure couldt-e2: args2Role-mention-ngram: could be blockedt]trigger-to-trigger-path: e1:induced:Negative_regulation >ccomp e2:blocked:Positive_regulationtee1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_producttRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ir'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='ir'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='block'] >nsubjpass [lemma='phosphorylation'] controlledt:e1: trigger-arg-path: induced >ccomp >nsubjpass controlledt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='ir'] Negative_regulationtKe2: trigger-arg-path: Positive_regulation nsubj Negative_regulationtxe2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj [lemma='ir'] controlledt#e2: args2Role-mention-ngram: FiguretJe1: trigger-arg-path: induced >ccomp >nsubjpass controlled:Phosphorylationtge2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibitor'] >nn [lemma='erbb1'] controllertKe1: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass controlledtne2: trigger-arg-path: lemmatizedTrigger=block:Positive_regulation nsubj controlled:Negative_regulationtqe2: trigger-arg-path: lemmatizedTrigger=block >agent [lemma='inhibitor'] >nn [lemma='erbb1'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: in Figuret&e2: args2Role-mention-ngram: in Figuretme2: trigger-arg-path: lemmatizedTrigger=block nsubj [lemma='ir'] Negative_regulationtIe2: trigger-arg-path: produce:Positive_regulation nsubj controllerte2: trigger: producetOe2: trigger-arg-path: lemmatizedTrigger=produce nsubj controller:Complext[e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj controllertce2: trigger-arg-path: lemmatizedTrigger=produce nsubj [lemma='ra'] controllert$e2: args2Role-mention-ngram: producetme2: trigger-arg-path: produce:Positive_regulation nsubj [lemma='ra'] controller:ComplextUe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp controlledt3e2: args2Role-mention-ngram: produce the CONTROLLEDtCe2: trigger-arg-path: produce:Positive_regulation >ccomp controlledtwe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj [lemma='ra'] controllert;e2: trigger-arg-path: Positive_regulation >ccomp controlledtte2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj [lemma='ra'] Complext,e2: trigger-arg-path: produce >ccomp Bindingt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to producetatrigger-to-trigger-path: e1:bound:Binding nsubj [lemma='ra'] controllert>e2: trigger-arg-path: Positive_regulation nsubj Complextfshortest-path: nsubj [lemma='ra']t>e2: trigger-arg-path: lemmatizedTrigger=produce >ccomp BindingtYe2: trigger-arg-path: produce nsubj [lemma='ra'] controller:Complext0e2: ents2Label-mention-ngram: produce the SHAREDt]e2: trigger-arg-path: Positive_regulation nsubj [lemma='ra'] controllertKe2: trigger-arg-path: produce:Positive_regulation >ccomp controlled:BindingtNe2: trigger-arg-path: produce nsubj [lemma='ra'] ComplextOtrigger-to-trigger-path: e1:bound:Binding ccomp [lemma='bind'] controlled:Bindingt;e2: trigger-arg-path: produce >ccomp [lemma='bind'] Bindingt'e2: args2Role-mention-ngram: to producetee2: trigger-arg-path: produce:Positive_regulation nsubj [lemma='ra'] controllert+e2: args2Role-mention-ngram: to produce thet,e2: ents2Label-mention-ngram: to produce thetRe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp Bindingt>e2: trigger-arg-path: produce >ccomp [lemma='bind'] controlledtXe2: trigger-arg-path: lemmatizedTrigger=produce >ccomp [lemma='bind'] controlled:BindingtCe2: trigger-arg-path: Positive_regulation >ccomp controlled:BindingtFe2: trigger-arg-path: produce >ccomp [lemma='bind'] controlled:Bindingtce2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj controller:ComplextAe2: trigger-arg-path: Positive_regulation nsubj controllertMe2: trigger-arg-path: lemmatizedTrigger=produce >ccomp [lemma='bind'] Bindingt8e2: trigger-arg-path: Positive_regulation >ccomp Bindingt/e2: trigger-arg-path: produce >ccomp controlledtIe2: trigger-arg-path: lemmatizedTrigger=produce >ccomp controlled:BindingtQe2: trigger-arg-path: produce:Positive_regulation nsubj controller:Complextke2: trigger-arg-path: lemmatizedTrigger=produce nsubj [lemma='ra'] controller:Complext2e2: args2Role-mention-ngram: CONTROLLER to producetbe2: trigger-arg-path: produce:Positive_regulation nsubj [lemma='ra'] Complext7e2: trigger-arg-path: produce >ccomp controlled:BindingtGe2: trigger-arg-path: lemmatizedTrigger=produce nsubj controllertee2: trigger-arg-path: Positive_regulation nsubj [lemma='ra'] controller:Complextde2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp [lemma='bind'] controlledtae2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp [lemma='bind'] Bindingt)shortest-path: nsubjtOe2: trigger-arg-path: produce:Positive_regulation >ccomp [lemma='bind'] BindingtXe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj Complext5e2: trigger-arg-path: produce nsubj controllerte2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj [lemma='ra'] controller:ComplextFe2: trigger-arg-path: produce:Positive_regulation nsubj Complext;e2: ents2Label-mention-ngram: bound GENE_OR_GENE_PRODUCT tot@e2: trigger-arg-path: produce:Positive_regulation >ccomp BindingtRe2: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] controlled:BindingtPe2: trigger-arg-path: lemmatizedTrigger=produce >ccomp [lemma='bind'] controlledt%e2: ents2Label-mention-ngram: producetDe2: trigger-arg-path: lemmatizedTrigger=produce nsubj Complext)e2: ents2Label-mention-ngram: produce thet2e2: trigger-arg-path: produce nsubj ComplextIe2: trigger-arg-path: Positive_regulation nsubj controller:ComplextRe2: trigger-arg-path: produce:Positive_regulation >ccomp [lemma='bind'] controlledt(e2: args2Role-mention-ngram: produce thetJe2: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] controlledtGe2: trigger-arg-path: Positive_regulation >ccomp [lemma='bind'] Bindingt`e2: trigger-arg-path: lemmatizedTrigger=produce nsubj [lemma='ra'] Complext]e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp controlled:BindingtZe2: trigger-arg-path: Positive_regulation nsubj [lemma='ra'] Complext=e2: trigger-arg-path: produce nsubj controller:ComplextAe2: trigger-arg-path: lemmatizedTrigger=produce >ccomp controlledtle2: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >ccomp [lemma='bind'] controlled:Bindingt@e1: trigger-arg-path: promotes >nsubj [lemma='twist'] controllert*e1: args2Role-mention-ngram: in high-gradet(e2: args2Role-mention-ngram: and reducedt]e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='hdac1'] theme:Gene_or_gene_productte1: args2Role-mention-ngram: BCtie2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='hdac1'] Gene_or_gene_productthe1: trigger-arg-path: promotes >dobj [lemma='downregulation'] >prep_of [lemma='er'] Gene_or_gene_producttie1: trigger-arg-path: Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlledt"e1: ents2Label-mention-ngram: BC ,tae2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_of theme:Gene_or_gene_producttye2: trigger-arg-path: recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] theme:Gene_or_gene_producttge2: trigger-arg-path: Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] Gene_or_gene_productt1e1: args2Role-mention-ngram: a gene overexpressedtKshortest-path: prep_through [lemma='recruitment']tEe2: trigger-arg-path: Binding >conj_and >prep_of Gene_or_gene_producttDe1: trigger-arg-path: promotes:Positive_activation >nsubj controllert,e1: ents2Label-mention-ngram: downregulationt2e2: ents2Label-mention-ngram: expression of SHAREDt.e1: ents2Label-mention-ngram: in high-grade BCtme2: trigger-arg-path: Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_of themetUe2: trigger-arg-path: recruitment >prep_of [lemma='hdac1'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: THEME and reducedt+e1: ents2Label-mention-ngram: overexpressedtje1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: a genetse2: trigger-arg-path: recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: and reduced expressiontZe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='hdac1'] themet)interceding-tokens-full-span: through thetfe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='twist'] controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='twist'] controllertXe2: trigger-arg-path: Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] themet?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] Gene_or_gene_producttqe2: trigger-arg-path: recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >prep_of Gene_or_gene_producttse1: trigger-arg-path: promotes >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlled:Gene_or_gene_producttUe1: trigger-arg-path: Positive_activation >nsubj [lemma='twist'] Gene_or_gene_producttse1: trigger-arg-path: Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] Gene_or_gene_productt4e1: args2Role-mention-ngram: promotes downregulationt7e1: args2Role-mention-ngram: promotes downregulation oft"e1: ents2Label-mention-ngram: genet]e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >prep_of controlledtHe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='hdac1'] themet>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and reducedt?e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: , promotes downregulationtRe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='hdac1'] themet*e1: args2Role-mention-ngram: BC , promotest-e1: args2Role-mention-ngram: in high-grade BCtde2: trigger-arg-path: recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] themetQe2: trigger-arg-path: Binding >prep_of [lemma='hdac1'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: overexpressed in high-gradet]trigger-to-trigger-path: e1:promotes:Positive_activation >prep_through e2:recruitment:Bindingt#e1: args2Role-mention-ngram: a genet9e1: args2Role-mention-ngram: downregulation of CONTROLLEDtLe2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_of themet+e1: ents2Label-mention-ngram: high-grade BCtTe1: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='twist'] controllertUe1: trigger-arg-path: promotes >nsubj [lemma='twist'] controller:Gene_or_gene_producttWe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='hdac1'] Gene_or_gene_producttBe2: trigger-arg-path: recruitment:Binding >conj_and >prep_of themet,e1: args2Role-mention-ngram: high-grade BC ,t[e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='twist'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: reduced expressiontUe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj controllertJe1: trigger-arg-path: promotes >nsubj [lemma='twist'] Gene_or_gene_producttKe1: trigger-arg-path: Positive_activation >nsubj [lemma='twist'] controllert+e1: args2Role-mention-ngram: downregulationt@e2: trigger-arg-path: recruitment >prep_of [lemma='hdac1'] themetie1: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='twist'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: downregulation oft\e2: trigger-arg-path: recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] themetoe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='twist'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >conj_and >prep_of theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: promotes downregulation oft/e2: args2Role-mention-ngram: reduced expressiontge2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='hdac1'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: overexpressedt+e1: ents2Label-mention-ngram: in high-gradetWe2: trigger-arg-path: recruitment:Binding >conj_and >prep_of theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: reduced expression oft_e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj Gene_or_gene_productt(e1: ents2Label-mention-ngram: high-gradet#shortest-path: prep_throught`e1: trigger-arg-path: Positive_activation >nsubj [lemma='twist'] controller:Gene_or_gene_productt8e1: args2Role-mention-ngram: overexpressed in high-gradetIe2: trigger-arg-path: recruitment >conj_and >prep_of Gene_or_gene_productt!e1: args2Role-mention-ngram: BC ,t~e1: trigger-arg-path: Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: gene overexpressed intKe2: trigger-arg-path: Binding >prep_of [lemma='hdac1'] Gene_or_gene_producttke2: trigger-arg-path: recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] Gene_or_gene_producttYe1: trigger-arg-path: promotes:Positive_activation >nsubj controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_of Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] Gene_or_gene_productt^e1: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='twist'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='hdac1'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: overexpressed intre1: trigger-arg-path: promotes:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlledtne2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] themet'e1: args2Role-mention-ngram: high-gradetstrigger-to-trigger-path: e1:promotes:Positive_activation >prep_through [lemma='recruitment'] e2:recruitment:Bindingt!e1: args2Role-mention-ngram: genet3e2: args2Role-mention-ngram: and reduced expressiont?e2: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='expression'] >prep_of [lemma='er'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: gene overexpressed intee1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='twist'] controllert/e1: args2Role-mention-ngram: gene overexpressedt)e2: ents2Label-mention-ngram: and reducedt-e1: ents2Label-mention-ngram: high-grade BC ,t%e1: args2Role-mention-ngram: , a genetprep_of [lemma='hdac1'] themet?e1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlled:Gene_or_gene_productt6e1: args2Role-mention-ngram: , promotes downregulationt5e1: ents2Label-mention-ngram: promotes downregulationt:e2: trigger-arg-path: recruitment >conj_and >prep_of themet6e2: trigger-arg-path: Binding >conj_and >prep_of themetre1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttNe1: trigger-arg-path: promotes:Positive_activation >nsubj Gene_or_gene_producttVe1: trigger-arg-path: promotes:Positive_activation >dobj >prep_of Gene_or_gene_productt0e2: args2Role-mention-ngram: expression of THEMEt&e1: ents2Label-mention-ngram: , a genet*e1: args2Role-mention-ngram: high-grade BCt?e1: trigger-arg-path: promotes:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlled:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_of Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='downregulation'] >prep_of [lemma='er'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='twist'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlledtOe2: trigger-arg-path: recruitment >conj_and >prep_of theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: , promotest(e1: ents2Label-mention-ngram: , promotest|e1: trigger-arg-path: promotes:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: BC , promotestae2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='hdac1'] Gene_or_gene_producttae1: trigger-arg-path: promotes:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt-e1: args2Role-mention-ngram: overexpressed intOe2: trigger-arg-path: recruitment >prep_of [lemma='hdac1'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: a gene overexpressedt e1: ents2Label-mention-ngram: BCtAe2: ents2Label-mention-ngram: recruitment of GENE_OR_GENE_PRODUCTtie2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_of theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlled:Gene_or_gene_productt9e2: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT andt6e1: ents2Label-mention-ngram: downregulation of SHAREDtLe1: trigger-arg-path: promotes:Positive_activation >dobj >prep_of controlledt3e2: ents2Label-mention-ngram: reduced expression oft^e1: trigger-arg-path: promotes >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='downregulation'] >prep_of [lemma='er'] controlledtQe2: trigger-arg-path: recruitment:Binding >conj_and >prep_of Gene_or_gene_productt0e1: ents2Label-mention-ngram: gene overexpressedt/e1: ents2Label-mention-ngram: downregulation oftve2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='expression'] >prep_of [lemma='er'] themet%e1: ents2Label-mention-ngram: TRbeta1t/e2: args2Role-mention-ngram: the interaction oft]e2: trigger-arg-path: enhanced:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: of MAPKt1e2: args2Role-mention-ngram: TRbeta1 and enhancedt,e1: ents2Label-mention-ngram: interaction oft1e1: args2Role-mention-ngram: activated CONTROLLEDt/e2: args2Role-mention-ngram: to the interactiontme2: trigger-arg-path: enhanced >nsubj [lemma='signalling'] >nn [lemma='mapk'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: TRbeta1 andt?e2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: MAPKt$e2: args2Role-mention-ngram: TRbeta1t,e2: args2Role-mention-ngram: the interactiont(e2: args2Role-mention-ngram: TRbeta1 andtnsubj [lemma='t4'] controllert0e2: args2Role-mention-ngram: enhanced CONTROLLEDt/e2: ents2Label-mention-ngram: SHARED signallingt,e1: ents2Label-mention-ngram: signalling ledt0e2: ents2Label-mention-ngram: the interaction oft%e1: ents2Label-mention-ngram: of MAPKt.e2: ents2Label-mention-ngram: with TRbeta1 andt+e2: args2Role-mention-ngram: interaction oft*e1: ents2Label-mention-ngram: of MAPK witht,e2: ents2Label-mention-ngram: interaction oft(e2: ents2Label-mention-ngram: led to thetne2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: to the interactiontMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='t4'] Simple_chemicalt*e2: ents2Label-mention-ngram: and enhancedtie2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='signalling'] >nn [lemma='mapk'] controllert'e2: args2Role-mention-ngram: led to thetxe2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: phosphorylation and SHAREDt*e2: ents2Label-mention-ngram: of MAPK witht)e2: args2Role-mention-ngram: with TRbeta1t$e2: args2Role-mention-ngram: of MAPKt6e1: ents2Label-mention-ngram: enhanced phosphorylationtrtrigger-to-trigger-path: e1:activated:Positive_regulation >ccomp [lemma='enhance'] e2:enhanced:Positive_regulationtbe2: trigger-arg-path: enhanced >nsubj [lemma='signalling'] >nn [lemma='mapk'] Gene_or_gene_productt0e2: args2Role-mention-ngram: interaction of MAPKt:e1: ents2Label-mention-ngram: enhanced phosphorylation andt3e2: ents2Label-mention-ngram: SHARED signalling ledt3e1: ents2Label-mention-ngram: SHARED signalling ledt2e2: ents2Label-mention-ngram: TRbeta1 and enhancedtTe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='t4'] Simple_chemicalt+e2: args2Role-mention-ngram: signalling ledt,e2: ents2Label-mention-ngram: signalling ledtce2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controllert:e1: ents2Label-mention-ngram: and enhanced phosphorylationtce2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >nn Gene_or_gene_productt"e1: ents2Label-mention-ngram: MAPKt'e2: ents2Label-mention-ngram: MAPK withtse2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='signalling'] >nn [lemma='mapk'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: signalling led tot-e2: args2Role-mention-ngram: with TRbeta1 andt>e2: trigger-arg-path: enhanced >nsubj >nn Gene_or_gene_productt&e2: args2Role-mention-ngram: MAPK witht.e1: ents2Label-mention-ngram: with TRbeta1 andtRe1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='t4'] controllert7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL activatedtIe2: trigger-arg-path: enhanced >nsubj >nn controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: of MAPK witht)e2: args2Role-mention-ngram: and enhancedt6e2: ents2Label-mention-ngram: enhanced phosphorylationt/e1: ents2Label-mention-ngram: MAPK with TRbeta1tve2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: ledt"e2: ents2Label-mention-ngram: MAPKt(e1: ents2Label-mention-ngram: led to thetXe2: trigger-arg-path: enhanced >nsubj [lemma='signalling'] >nn [lemma='mapk'] controllert2e1: ents2Label-mention-ngram: TRbeta1 and enhancedtCe1: trigger-arg-path: activated >nsubj [lemma='t4'] Simple_chemicalt}e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controllert.e2: args2Role-mention-ngram: MAPK with TRbeta1t_e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='t4'] controller:Simple_chemicalt9e1: ents2Label-mention-ngram: activated SHARED signallingt/e1: ents2Label-mention-ngram: SHARED signallingtXe1: trigger-arg-path: Positive_regulation >nsubj [lemma='t4'] controller:Simple_chemicalt.e2: args2Role-mention-ngram: signalling led totbe1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='t4'] controller:Simple_chemicaltNe1: trigger-arg-path: activated >nsubj [lemma='t4'] controller:Simple_chemicalt'e1: ents2Label-mention-ngram: MAPK witht*e1: ents2Label-mention-ngram: with TRbeta1tZe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >nn controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: TRbeta1t:e2: ents2Label-mention-ngram: enhanced phosphorylation andt$e1: ents2Label-mention-ngram: led tot.e1: ents2Label-mention-ngram: activated SHAREDt1e1: ents2Label-mention-ngram: interaction of MAPKthe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj [lemma='t4'] Simple_chemicalt-e2: ents2Label-mention-ngram: the interactiontse1: trigger-arg-path: lemmatizedTrigger=activate:Positive_regulation >nsubj [lemma='t4'] controller:Simple_chemicaltOe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >nn Gene_or_gene_productt/e2: ents2Label-mention-ngram: MAPK with TRbeta1t:e2: ents2Label-mention-ngram: and enhanced phosphorylationtHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='t4'] controllert?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] Gene_or_gene_producttWe1: trigger-arg-path: activated:Positive_regulation >nsubj [lemma='t4'] Simple_chemicaltRe2: trigger-arg-path: enhanced:Positive_regulation >nsubj >nn Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >nn controllert)e2: ents2Label-mention-ngram: TRbeta1 andt/e2: ents2Label-mention-ngram: signalling led totle2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controllert8e1: ents2Label-mention-ngram: phosphorylation and SHAREDtYe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >nn controllert6e2: args2Role-mention-ngram: CONTROLLER signalling ledt>e1: trigger-arg-path: activated >nsubj [lemma='t4'] controllert~e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='signalling'] >nn [lemma='mapk'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: to the interactiont`trigger-to-trigger-path: e1:activated:Positive_regulation >ccomp e2:enhanced:Positive_regulationt0e1: ents2Label-mention-ngram: the interaction oft?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] controller:Gene_or_gene_producttme2: trigger-arg-path: Positive_regulation >nsubj [lemma='signalling'] >nn [lemma='mapk'] Gene_or_gene_producttHe2: trigger-arg-path: enhanced:Positive_regulation >nsubj >nn controllert>e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL activated SHAREDt4e2: trigger-arg-path: enhanced >nsubj >nn controllert*e2: ents2Label-mention-ngram: with TRbeta1tpshortest-path: ccomp [lemma='enhance'] >nsubj [lemma='signalling'] >nn [lemma='mapk']t1e2: ents2Label-mention-ngram: interaction of MAPKt4e2: args2Role-mention-ngram: and enhanced CONTROLLEDt*e1: ents2Label-mention-ngram: and enhancedtOe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='t4'] controllert4e1: ents2Label-mention-ngram: also polyubiquitinatest;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( hsRPB7t%e2: ents2Label-mention-ngram: seventhtVe2: trigger-arg-path: lemmatizedTrigger=suppress advmod Positive_regulationtbe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj >nn controller:Gene_or_gene_producttnsubj controllertCe2: ents2Label-mention-ngram: hsRPB7 dependent GENE_OR_GENE_PRODUCTt?e2: trigger-arg-path: lemmatizedTrigger=suppress dobj [lemma='transactivation'] >nn [lemma='vegf'] Gene_or_gene_productt?e2: trigger-arg-path: Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj >nn controllert4e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT (t%e2: args2Role-mention-ngram: ( hsRPB7t?e2: trigger-arg-path: lemmatizedTrigger=suppress dobj [lemma='transactivation'] >nn [lemma='vegf'] controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: suppresses hsRPB7tOe2: trigger-arg-path: lemmatizedTrigger=suppress dobj >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=suppress advmod [lemma='also'] Positive_regulationthe2: trigger-arg-path: suppresses:Negative_regulation dobj >nn controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: subunit oftNe1: trigger-arg-path: polyubiquitinates >nsubj controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: seventht?e2: trigger-arg-path: Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controllert)e1: ents2Label-mention-ngram: the seventht]e2: trigger-arg-path: suppresses:Negative_regulation dobj >nn Gene_or_gene_producttfe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='pvhl'] Gene_or_gene_productt?e2: trigger-arg-path: suppresses dobj [lemma='transactivation'] >nn [lemma='vegf'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj controllert?e2: trigger-arg-path: suppresses dobj >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod [lemma='also'] controlledt0e2: ents2Label-mention-ngram: seventh subunit oft7e1: ents2Label-mention-ngram: II ( GENE_OR_GENE_PRODUCTte1: trigger: polyubiquitinatest=e2: trigger-arg-path: suppresses advmod controlledt8e2: args2Role-mention-ngram: hsRPB7 dependent CONTROLLERt8e1: ents2Label-mention-ngram: also polyubiquitinates thetae2: trigger-arg-path: lemmatizedTrigger=suppress advmod controlled:Positive_regulationt,e1: args2Role-mention-ngram: also CONTROLLEDt/e1: ents2Label-mention-ngram: polyubiquitinatestFe2: trigger-arg-path: suppresses advmod Positive_regulationt?e2: trigger-arg-path: Negative_regulation advmod [lemma='also'] controlled:Positive_regulationtse1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj controller:Gene_or_gene_producttQe2: trigger-arg-path: suppresses:Negative_regulation advmod controlledt2e1: ents2Label-mention-ngram: human RNA polymerasetJe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj controllert?e2: trigger-arg-path: suppresses:Negative_regulation advmod [lemma='also'] Positive_regulationt(e2: ents2Label-mention-ngram: ( hsRPB7 )tme1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='pvhl'] controllert-e2: ents2Label-mention-ngram: seventh subunitt?e2: trigger-arg-path: suppresses:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controllert?e2: trigger-arg-path: suppresses:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: suppresses hsRPB7t&e2: ents2Label-mention-ngram: ( hsRPB7t?e2: trigger-arg-path: suppresses:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controller:Gene_or_gene_producttHe1: trigger-arg-path: polyubiquitinates >nsubj [lemma='pvhl'] controllertde2: trigger-arg-path: lemmatizedTrigger=suppress dobj >nn controller:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=suppress advmod [lemma='also'] controlledt;e2: ents2Label-mention-ngram: SHARED also polyubiquitinatest'e2: args2Role-mention-ngram: ( hsRPB7 )t?e2: trigger-arg-path: suppresses dobj [lemma='transactivation'] >nn [lemma='vegf'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='pvhl'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: the seventh subunittwe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='pvhl'] Gene_or_gene_producttCe1: trigger-arg-path: polyubiquitinates >nsubj Gene_or_gene_productt*e2: ents2Label-mention-ngram: hsRPB7 ) andt\e1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='pvhl'] controllert.e2: ents2Label-mention-ngram: ) and suppressest1e2: args2Role-mention-ngram: dependent CONTROLLERtMe2: trigger-arg-path: lemmatizedTrigger=suppress advmod controlledt9e2: ents2Label-mention-ngram: suppresses hsRPB7 dependentt_e1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj controller:Gene_or_gene_productt9e1: trigger-arg-path: polyubiquitinates >nsubj controllertZe2: trigger-arg-path: suppresses:Negative_regulation advmod Positive_regulationtue2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod controlled:Positive_regulationtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pvhl'] Gene_or_gene_producttpe2: trigger-arg-path: Negative_regulation advmod [lemma='also'] controlledtje2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod Positive_regulationtge2: trigger-arg-path: suppresses advmod [lemma='also'] controlledt'e1: ents2Label-mention-ngram: human RNAt!e1: ents2Label-mention-ngram: RNAtce1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='pvhl'] Gene_or_gene_productt2e2: args2Role-mention-ngram: and suppresses hsRPB7t/e2: ents2Label-mention-ngram: polyubiquitinatest.e2: ents2Label-mention-ngram: subunit of humante2: trigger: suppressest?e2: trigger-arg-path: suppresses:Negative_regulation advmod [lemma='also'] controlled:Positive_regulationtQe2: trigger-arg-path: suppresses advmod controlled:Positive_regulationt]e1: trigger-arg-path: polyubiquitinates >nsubj [lemma='pvhl'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: SHARED also polyubiquitinatest{e2: trigger-arg-path: suppresses advmod [lemma='also'] controlled:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controllertRe1: trigger-arg-path: polyubiquitinates >nsubj [lemma='pvhl'] Gene_or_gene_producttIe2: trigger-arg-path: suppresses dobj >nn Gene_or_gene_productt?trigger-to-trigger-path: e1:polyubiquitinates:Positive_regulation >conj_and [lemma='suppress'] e2:suppresses:Negative_regulationt]e2: trigger-arg-path: Negative_regulation dobj >nn controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: seventh subunitt3e1: ents2Label-mention-ngram: polyubiquitinates thetTe2: trigger-arg-path: suppresses dobj >nn controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: subunittpe2: trigger-arg-path: suppresses advmod [lemma='also'] Positive_regulationt0e2: args2Role-mention-ngram: CONTROLLED ( hsRPB7t?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Negative_regulation dobj [lemma='transactivation'] >nn [lemma='vegf'] Gene_or_gene_producttOe2: trigger-arg-path: Negative_regulation advmod Positive_regulationt1e2: ents2Label-mention-ngram: the seventh subunitt.e2: ents2Label-mention-ngram: hsRPB7 dependenttRe2: trigger-arg-path: Negative_regulation dobj >nn Gene_or_gene_productt3e2: ents2Label-mention-ngram: polyubiquitinates thet%e2: args2Role-mention-ngram: hsRPB7 )tye2: trigger-arg-path: Negative_regulation advmod [lemma='also'] Positive_regulationt4e2: ents2Label-mention-ngram: also polyubiquitinatestmtrigger-to-trigger-path: e1:polyubiquitinates:Positive_regulation >conj_and e2:suppresses:Negative_regulationt$e2: ents2Label-mention-ngram: hsRPB7tZe2: trigger-arg-path: Negative_regulation advmod controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='pvhl'] controller:Gene_or_gene_producttSe2: trigger-arg-path: suppresses:Negative_regulation dobj >nn controllert%e1: ents2Label-mention-ngram: subunitt?e2: trigger-arg-path: lemmatizedTrigger=suppress advmod [lemma='also'] controlled:Positive_regulationtYe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='pvhl'] controllert;e2: ents2Label-mention-ngram: of human GENE_OR_GENE_PRODUCTt(e2: ents2Label-mention-ngram: subunit oft_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='pvhl'] controller:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj Gene_or_gene_productt(e1: ents2Label-mention-ngram: polymerasetJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pvhl'] controllert-e2: args2Role-mention-ngram: ) and suppressest&e2: ents2Label-mention-ngram: hsRPB7 )t.e1: ents2Label-mention-ngram: subunit of humantWe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj Gene_or_gene_productt;e2: ents2Label-mention-ngram: polyubiquitinates the seventht8e2: args2Role-mention-ngram: suppresses hsRPB7 dependentt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod [lemma='also'] Positive_regulationt8e2: ents2Label-mention-ngram: also polyubiquitinates thetFe2: trigger-arg-path: Negative_regulation advmod controlledtGshortest-path: advmod [lemma='also']tHe2: trigger-arg-path: Negative_regulation dobj >nn controllert)e2: args2Role-mention-ngram: hsRPB7 ) andtYe2: trigger-arg-path: lemmatizedTrigger=suppress dobj >nn Gene_or_gene_productt-e1: ents2Label-mention-ngram: polymerase II (t?e2: trigger-arg-path: suppresses dobj [lemma='transactivation'] >nn [lemma='vegf'] controllert8e2: ents2Label-mention-ngram: human GENE_OR_GENE_PRODUCTt3e2: ents2Label-mention-ngram: and suppresses hsRPB7tme2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation dobj >nn Gene_or_gene_producttee2: trigger-arg-path: suppresses:Negative_regulation advmod controlled:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod [lemma='also'] controlled:Positive_regulationtae2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation advmod controlledt)e2: ents2Label-mention-ngram: the seventht/e1: ents2Label-mention-ngram: RNA polymerase IIt?e2: trigger-arg-path: lemmatizedTrigger=suppress dobj [lemma='transactivation'] >nn [lemma='vegf'] controllert,e1: ents2Label-mention-ngram: RNA polymeraset+e1: ents2Label-mention-ngram: polymerase IItTe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj Gene_or_gene_productt:e2: ents2Label-mention-ngram: human GENE_OR_GENE_PRODUCT (t7e1: args2Role-mention-ngram: CONTROLLER also CONTROLLEDt;e1: ents2Label-mention-ngram: polyubiquitinates the seventhtqe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='pvhl'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: and suppressest-e2: args2Role-mention-ngram: hsRPB7 dependentt+e2: args2Role-mention-ngram: and suppressest*e1: ents2Label-mention-ngram: of human RNAt{e2: trigger-arg-path: suppresses:Negative_regulation advmod [lemma='also'] controlledt0e1: ents2Label-mention-ngram: seventh subunit oft#e2: args2Role-mention-ngram: hsRPB7t)e2: ents2Label-mention-ngram: RING fingert.e2: ents2Label-mention-ngram: in promoting p53t]e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controllert|e2: trigger-arg-path: Positive_activation nsubj [lemma='pias1'] controller:Gene_or_gene_producttqe1: trigger-arg-path: sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controller:Gene_or_gene_productt=e2: trigger-arg-path: activate >dobj [lemma='p53'] controlledt(e2: args2Role-mention-ngram: sumoylationt(interceding-token ngrams: demonstrated ,tce2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p53'] controlledt*e2: args2Role-mention-ngram: promoting p53t*interceding-token ngrams: demonstrated , at(e2: args2Role-mention-ngram: like domaint7e2: ents2Label-mention-ngram: promoting p53 sumoylationt3e1: ents2Label-mention-ngram: sumoylation of SHAREDt'e2: ents2Label-mention-ngram: defectivet.e2: ents2Label-mention-ngram: RING finger liketze2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pias1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pias1'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: to activatet0e2: ents2Label-mention-ngram: to activate SHAREDtOe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p53'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pias1'] Gene_or_gene_productt`e2: trigger-arg-path: activate:Positive_activation nsubj controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of >prep_by Gene_or_gene_productt!e2: args2Role-mention-ngram: liket8e2: ents2Label-mention-ngram: sumoylation was sufficientt?interceding-tokens-full-span: has been demonstrated , a mutatedt*e2: ents2Label-mention-ngram: defective intHe1: trigger-arg-path: sumoylation >prep_of >prep_by Gene_or_gene_productt1e2: args2Role-mention-ngram: domain and defectivet?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pias1'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pias1'] Gene_or_gene_producttHe2: trigger-arg-path: Positive_activation >dobj [lemma='p53'] controlledt+e2: ents2Label-mention-ngram: promoting p53t3e2: args2Role-mention-ngram: defective in promotingt$e2: ents2Label-mention-ngram: fingert-e2: args2Role-mention-ngram: in promoting p53t-e2: ents2Label-mention-ngram: the RING fingert2e2: ents2Label-mention-ngram: domain and defectivet-e2: ents2Label-mention-ngram: like domain andt(e2: args2Role-mention-ngram: RING fingert&e2: args2Role-mention-ngram: defectivet7e2: args2Role-mention-ngram: sumoylation was sufficientte2: incoming: prep_of [lemma='p53'] >prep_by [lemma='pias1'] controllertpe2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pias1'] controllert,e2: ents2Label-mention-ngram: SHARED lackingtxe1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] Gene_or_gene_producttne1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] Gene_or_gene_producttRe1: trigger-arg-path: sumoylation:Positive_regulation >prep_of >prep_by controllertPe1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of >prep_by controllert4e2: ents2Label-mention-ngram: sufficient to activatetLe2: trigger-arg-path: activate nsubj controller:Gene_or_gene_producttttrigger-to-trigger-path: e1:sumoylation:Positive_regulation xcomp e2:activate:Positive_activationt-e2: args2Role-mention-ngram: lacking the RINGt,e2: args2Role-mention-ngram: the RING fingertGe2: trigger-arg-path: activate >dobj [lemma='p53'] Gene_or_gene_producttde1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controllert(e2: args2Role-mention-ngram: to activatet"e2: ents2Label-mention-ngram: RINGt.e2: args2Role-mention-ngram: was sufficient totSe2: trigger-arg-path: lemmatizedTrigger=activate nsubj Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p53'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=activate nsubj controllertAe2: trigger-arg-path: activate nsubj Gene_or_gene_producttye1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: like domain andtRe2: trigger-arg-path: Positive_activation >dobj [lemma='p53'] Gene_or_gene_productt\e2: trigger-arg-path: activate nsubj [lemma='pias1'] controllertne2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pias1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pias1'] controllert3e2: args2Role-mention-ngram: to activate CONTROLLEDt)e2: args2Role-mention-ngram: defective int*e2: args2Role-mention-ngram: and defectivet%interceding-token ngrams: , a mutatedtde2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p53'] controlled:Gene_or_gene_productt#e2: args2Role-mention-ngram: fingert%e2: ents2Label-mention-ngram: lackingt7e2: trigger-arg-path: activate nsubj controllert-e2: args2Role-mention-ngram: RING finger liket)e2: ents2Label-mention-ngram: lacking thet)e2: ents2Label-mention-ngram: finger liket3e2: args2Role-mention-ngram: CONTROLLER lacking thetKe2: trigger-arg-path: activate:Positive_activation nsubj controllert?trigger-to-trigger-path: e1:sumoylation:Positive_regulation xcomp [lemma='activate'] e2:activate:Positive_activationt/e2: ents2Label-mention-ngram: was sufficient tot(e2: args2Role-mention-ngram: finger liket^e2: trigger-arg-path: lemmatizedTrigger=activate nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=sumoylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] Gene_or_gene_producttfe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='p53'] controlled:Gene_or_gene_productt-e2: ents2Label-mention-ngram: sumoylation wastbshortest-path: nsubj [lemma='pias1']tUe2: trigger-arg-path: activate:Positive_activation nsubj Gene_or_gene_producttze1: trigger-arg-path: sumoylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] Gene_or_gene_productt[e2: trigger-arg-path: activate:Positive_activation >dobj [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pias1'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER lackingtne1: trigger-arg-path: lemmatizedTrigger=sumoylation:Positive_regulation >prep_of >prep_by Gene_or_gene_producttqe2: trigger-arg-path: Positive_activation nsubj [lemma='pias1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=sumoylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: domain andt*e2: args2Role-mention-ngram: sufficient tot1e2: ents2Label-mention-ngram: p53 sumoylation wast+e2: ents2Label-mention-ngram: and defectivet'e2: args2Role-mention-ngram: sufficientt"e2: ents2Label-mention-ngram: liket%e2: args2Role-mention-ngram: the RINGt!interceding-token ngrams: mutatedt/interceding-token ngrams: has been demonstratedt]e2: trigger-arg-path: Positive_activation >dobj [lemma='p53'] controlled:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: p53 sumoylationtYe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p53'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: in promotingtee1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of >prep_by controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: sumoylation wast4e2: ents2Label-mention-ngram: defective in promotingt0e2: args2Role-mention-ngram: p53 sumoylation wast(e2: args2Role-mention-ngram: lacking thet/e2: args2Role-mention-ngram: finger like domaintne1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controllert(e2: ents2Label-mention-ngram: sufficientt(e2: ents2Label-mention-ngram: domain andt,e2: args2Role-mention-ngram: p53 sumoylationt'shortest-path: nsubjtqe2: trigger-arg-path: activate nsubj [lemma='pias1'] controller:Gene_or_gene_productt6e2: args2Role-mention-ngram: promoting p53 sumoylationt-interceding-token ngrams: been demonstrated ,t)e2: ents2Label-mention-ngram: like domaint.e2: ents2Label-mention-ngram: and defective int#interceding-token ngrams: a mutatedt+e2: ents2Label-mention-ngram: sufficient totSe1: trigger-arg-path: sumoylation >prep_of >prep_by controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: lackingt\e1: trigger-arg-path: sumoylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt,e2: ents2Label-mention-ngram: was sufficienttfe2: trigger-arg-path: activate nsubj [lemma='pias1'] Gene_or_gene_productt>e1: trigger-arg-path: sumoylation >prep_of >prep_by controllert0e2: ents2Label-mention-ngram: finger like domaint0e2: ents2Label-mention-ngram: SHARED lacking thetge2: trigger-arg-path: Positive_activation nsubj [lemma='pias1'] controllert+e2: args2Role-mention-ngram: was sufficientt&e2: ents2Label-mention-ngram: the RINGt3e2: args2Role-mention-ngram: sufficient to activatet?e1: trigger-arg-path: lemmatizedTrigger=sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controller:Gene_or_gene_producttge1: trigger-arg-path: sumoylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttpe1: trigger-arg-path: sumoylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controllerte1: trigger: sumoylationt,e1: ents2Label-mention-ngram: sumoylation oft)e2: args2Role-mention-ngram: in promotingtye1: trigger-arg-path: lemmatizedTrigger=sumoylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p53'] controlled:Gene_or_gene_productt!e2: args2Role-mention-ngram: RINGtRe2: trigger-arg-path: activate >dobj [lemma='p53'] controlled:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=sumoylation:Positive_regulation >prep_of >prep_by controllertQe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='p53'] controlledt-e2: args2Role-mention-ngram: and defective intge2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj Gene_or_gene_productt\e1: trigger-arg-path: sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controllertfe1: trigger-arg-path: sumoylation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] Gene_or_gene_productt?e1: trigger-arg-path: sumoylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='pias1'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: lacking the RINGtYe1: trigger-arg-path: phosphorylated >agent [lemma='akt'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >agent [lemma='skp2'] controller:Gene_or_gene_producttDe2: trigger-arg-path: ubiquitinated >agent [lemma='skp2'] controllertCe2: ents2Label-mention-ngram: ubiquitinated by GENE_OR_GENE_PRODUCTtUe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='skp2'] controllertZe1: trigger-arg-path: Positive_regulation agent [lemma='akt'] Gene_or_gene_producttYe2: trigger-arg-path: ubiquitinated >agent [lemma='skp2'] controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] controllertoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='akt'] controller:Gene_or_gene_producttEe1: trigger-arg-path: phosphorylated advcl >nsubjpasstbe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='akt'] controllertie2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='skp2'] controllertje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] controller:Gene_or_gene_producttXe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] controllertie1: trigger-arg-path: phosphorylated:Positive_regulation agent [lemma='akt'] Gene_or_gene_producttme1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] controller:Gene_or_gene_producttUe1: trigger-arg-path: phosphorylated advcl e2:ubiquitinated:Positive_regulationt)interceding-token ngrams: translocates tot_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] Gene_or_gene_producttOe1: trigger-arg-path: Positive_regulation advcl [lemma='ubiquitinate'] e2:ubiquitinated:Positive_regulationt^e1: trigger-arg-path: phosphorylated:Positive_regulation agent [lemma='akt'] controllertashortest-path: advcl [lemma='ubiquitinate'] >nsubjpass [lemma='it']tXe2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='skp2'] controllert(interceding-token ngrams: to the cytosoltVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='skp2'] controller:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='skp2'] controller:Gene_or_gene_producttDe1: trigger-arg-path: phosphorylated >agent [lemma='akt'] controllert-interceding-token ngrams: translocates to thetfe1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='skp2'] Gene_or_gene_producttbe2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='skp2'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='akt'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >agent [lemma='skp2'] controllertje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='skp2'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='skp2'] Gene_or_gene_productt+interceding-token ngrams: the cytosol wheretNe2: trigger-arg-path: ubiquitinated >agent [lemma='skp2'] Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >agent [lemma='akt'] controller:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='skp2'] controller:Gene_or_gene_productt'interceding-token ngrams: cytosol wheretdtrigger-to-trigger-path: e1:association:Binding >prep_between [lemma='complex'] e2:complexes:BindingtMe2: trigger-arg-path: complexes >nn [lemma='prohibitin'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='prohibitin'] themet?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] Gene_or_gene_productthe1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] themethe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between >nn theme:Gene_or_gene_productt}e1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] theme:Gene_or_gene_producttSe2: trigger-arg-path: complexes >nn [lemma='prohibitin'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='nuclear'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='nuclear'] themetYe1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] themetRe2: trigger-arg-path: complexes:Binding >nn [lemma='nuclear'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between >nn Gene_or_gene_producttQe2: trigger-arg-path: Binding >nn [lemma='prohibitin'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='prohibitin'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='nuclear'] Gene_or_gene_producttDe1: trigger-arg-path: Binding >prep_between >nn Gene_or_gene_producttoe1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] Gene_or_gene_producttVe1: trigger-arg-path: association:Binding >prep_between >nn theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='nuclear'] Gene_or_gene_productt\e1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] themetPe2: trigger-arg-path: complexes >nn [lemma='nuclear'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='prohibitin'] themet?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='prohibitin'] theme:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='nuclear'] Gene_or_gene_producttte1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] Gene_or_gene_producttne1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] theme:Gene_or_gene_productt;e2: trigger-arg-path: complexes >nn [lemma='nuclear'] themet`e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='nuclear'] theme:Gene_or_gene_productt]e1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='nuclear'] themet9e2: trigger-arg-path: Binding >nn [lemma='nuclear'] themetUe2: trigger-arg-path: complexes:Binding >nn [lemma='prohibitin'] Gene_or_gene_producttHe2: trigger-arg-path: Binding >nn [lemma='nuclear'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: SHARED complexest>e2: trigger-arg-path: complexes >nn [lemma='prohibitin'] themetSe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between >nn themetJe1: trigger-arg-path: Binding >prep_between >nn theme:Gene_or_gene_producttee1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] themetCe2: trigger-arg-path: complexes:Binding >nn [lemma='nuclear'] themethe1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] themetee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='prohibitin'] Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='nuclear'] themetFe2: trigger-arg-path: complexes:Binding >nn [lemma='prohibitin'] themetze1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] themethe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='nuclear'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=association >prep_between >nn themetke1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] Gene_or_gene_producttNe1: trigger-arg-path: association >prep_between >nn theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >nn [lemma='nuclear'] theme:Gene_or_gene_producttle1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='nuclear'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='prohibitin'] theme:Gene_or_gene_productt5e1: trigger-arg-path: Binding >prep_between >nn themet?e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] theme:Gene_or_gene_producttAe1: trigger-arg-path: association:Binding >prep_between >nn themetze1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='complex'] >nn [lemma='nuclear'] theme:Gene_or_gene_producttPe1: trigger-arg-path: association:Binding >prep_between >nn Gene_or_gene_productt9e1: trigger-arg-path: association >prep_between >nn themetre1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='nuclear'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='prohibitin'] Gene_or_gene_producttXe2: trigger-arg-path: complexes:Binding >nn [lemma='nuclear'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: and SHARED complexest`e1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] themetJe2: trigger-arg-path: complexes >nn [lemma='nuclear'] Gene_or_gene_productt[e2: trigger-arg-path: complexes:Binding >nn [lemma='prohibitin'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=association >prep_between >nn Gene_or_gene_producttHe1: trigger-arg-path: association >prep_between >nn Gene_or_gene_producttRtrigger-to-trigger-path: e1:association:Binding >prep_between e2:complexes:Bindingtue1: trigger-arg-path: association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] theme:Gene_or_gene_producttnn [lemma='prohibitin'] themet`e1: trigger-arg-path: lemmatizedTrigger=association >prep_between >nn theme:Gene_or_gene_producttwe1: trigger-arg-path: association:Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='complex'] >nn [lemma='prohibitin'] themetqe1: trigger-arg-path: Binding >prep_between [lemma='complex'] >nn [lemma='prohibitin'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='nuclear'] themet2e1: args2Role-mention-ngram: CONTROLLER suppressedt`e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppressedtWe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: suppressed:Negative_regulation >nsubj controller:Gene_or_gene_producttVe1: trigger-arg-path: Negative_regulation >nsubj [lemma='u73122'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='u73122'] controllertqe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='u73122'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='u73122'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: activation andtnsubj [lemma='u73122'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj controller:Gene_or_gene_producttle1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='u73122'] controller:Gene_or_gene_producttWe1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='u73122'] controllert=e1: args2Role-mention-ngram: CONTROLLER suppressed CONTROLLEDtXe1: trigger-arg-path: suppressed >nsubj [lemma='u73122'] controller:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj Gene_or_gene_producttGe1: trigger-arg-path: suppressed >nsubj controller:Gene_or_gene_producttUshortest-path: ccomp [lemma='induce'] >nsubj [lemma='egf']tnsubj Gene_or_gene_producttPe1: trigger-arg-path: suppressed:Negative_regulation >nsubj Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='u73122'] controller:Gene_or_gene_producttae1: trigger-arg-path: Negative_regulation >nsubj [lemma='u73122'] controller:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='u73122'] controllert|e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='u73122'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: activation andtCe1: trigger-arg-path: suppressed >nsubj [lemma='u73122'] controllertLe1: trigger-arg-path: Negative_regulation >nsubj [lemma='u73122'] controllertnsubj [lemma='u73122'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED activation andt3e1: ents2Label-mention-ngram: SHARED activation andtVe2: trigger-arg-path: phosphorylation nn [lemma='ampk'] controllert_e1: trigger-arg-path: Positive_activation >agent [lemma='ampk'] controller:Gene_or_gene_producttnn controllert/e1: ents2Label-mention-ngram: has been reportedt{e1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='ampk'] controllert+e1: ents2Label-mention-ngram: been reportedt,interceding-token ngrams: arrest although ittce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='ampk'] controllert\e1: trigger-arg-path: induced:Positive_activation >agent [lemma='ampk'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn [lemma='ampk'] Gene_or_gene_productt6e1: trigger-arg-path: induced agent [lemma='ampk'] controller:Gene_or_gene_producttinterceding-token ngrams: outt+e1: args2Role-mention-ngram: CONTROLLED hastCe2: trigger-arg-path: phosphorylation agent controller:Gene_or_gene_producttje1: trigger-arg-path: induced agent [lemma='ampk'] controller:Gene_or_gene_producttinterceding-token ngrams: 15tHe2: trigger-arg-path: phosphorylation agent [lemma='ampk'] Gene_or_gene_productte2: trigger-arg-path: phosphorylation:Positive_regulation nn [lemma='ampk'] controller:Gene_or_gene_productt!interceding-token ngrams: pointedt&interceding-token ngrams: been pointedtWe2: trigger-arg-path: phosphorylation:Positive_regulation agent Gene_or_gene_productt4interceding-token ngrams: through phosphorylation ontYe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ampk'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED has beentee1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation advcl [lemma='point'] >ccomp [lemma='ampk'] >nsubj [lemma='site'] >nn [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn Gene_or_gene_productt4e2: trigger-arg-path: phosphorylation advcl [lemma='point'] >ccomp [lemma='ampk'] >nsubj [lemma='site'] >nn [lemma='ampk']t#interceding-token ngrams: on serinet%interceding-token ngrams: although ittinterceding-token ngrams: 15 intfe1: trigger-arg-path: lemmatizedTrigger=induce nn controller:Gene_or_gene_productt9e2: trigger-arg-path: phosphorylation nn [lemma='ampk'] controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn [lemma='ampk'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: hast3interceding-token ngrams: nutrient stress resultingtZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nn [lemma='ampk'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent Gene_or_gene_productt9e1: trigger-arg-path: induced >agent Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn controllert9e2: ents2Label-mention-ngram: SHARED phosphorylation sitetge1: trigger-arg-path: induced:Positive_activation >agent [lemma='ampk'] controller:Gene_or_gene_productt%interceding-token ngrams: to nutrienttLe1: trigger-arg-path: Positive_activation advcl >ccomp >nsubj >nn e2:phosphorylation:Positive_regulationt.interceding-token ngrams: response to nutrientt(interceding-token ngrams: in response totde1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ampk'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: has been reportedthe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn [lemma='ampk'] controllertye2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation agent [lemma='ampk'] controllertUe1: trigger-arg-path: lemmatizedTrigger=induce >agent controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nn [lemma='ampk'] controllert8e2: trigger-arg-path: phosphorylation nn controllert,interceding-token ngrams: phosphorylation ont8e2: trigger-arg-path: Positive_regulation agent [lemma='ampk'] Gene_or_gene_productt"interceding-token ngrams: nutrientt3interceding-token ngrams: starvation induced growtht?interceding-tokens-full-span: through phosphorylation on serine 15 in response to nutrient stress resulting in a starvation induced growth arrest although it has been pointed out that thet_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn controller:Gene_or_gene_productt&interceding-token ngrams: on serine 15tBe2: trigger-arg-path: phosphorylation nn Gene_or_gene_productt%e2: ents2Label-mention-ngram: site intLe2: trigger-arg-path: phosphorylation:Positive_regulation nn controllertVe2: trigger-arg-path: phosphorylation:Positive_regulation nn Gene_or_gene_producttte2: trigger-arg-path: phosphorylation:Positive_regulation nn [lemma='ampk'] Gene_or_gene_productt@e1: trigger-arg-path: induced nn [lemma='ampk'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nn controller:Gene_or_gene_productt&interceding-token ngrams: a starvationt}e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nn [lemma='ampk'] controller:Gene_or_gene_productt$interceding-token ngrams: starvationt.e1: ents2Label-mention-ngram: been reported totke2: trigger-arg-path: phosphorylation nn [lemma='ampk'] controller:Gene_or_gene_productt#interceding-token ngrams: serine 15t`e2: trigger-arg-path: phosphorylation nn [lemma='ampk'] Gene_or_gene_producttae2: trigger-arg-path: phosphorylation:Positive_regulation nn controller:Gene_or_gene_productt)interceding-token ngrams: nutrient stresst%interceding-token ngrams: in responset e1: ents2Label-mention-ngram: betze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation e1: trigger-arg-path: induced >agent [lemma='ampk'] controllert&interceding-token ngrams: out that thet3interceding-token ngrams: phosphorylation on serinet"interceding-token ngrams: out thatt e1: args2Role-mention-ngram: hastSe2: trigger-arg-path: phosphorylation agent [lemma='ampk'] controllertpe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation agent controllert/e1: ents2Label-mention-ngram: induced by SHAREDte1: args2Role-mention-ngram: betUe1: trigger-arg-path: induced agent [lemma='ampk'] Gene_or_gene_producttQe2: trigger-arg-path: Positive_regulation nn controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nn controllert(e1: args2Role-mention-ngram: reported tot_e1: trigger-arg-path: induced:Positive_activation advcl >ccomp >nsubj >nntZe2: trigger-arg-path: Positive_regulation nn [lemma='ampk'] controllert1interceding-token ngrams: through phosphorylationt)e2: ents2Label-mention-ngram: in SHARED (tXe1: trigger-arg-path: induced:Positive_activation >agent controller:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ampk'] controllertKe2: trigger-arg-path: lemmatizedTrigger=phosphorylation agent controller:Gene_or_gene_producttCe1: trigger-arg-path: induced:Positive_activation >agent controllert*e1: args2Role-mention-ngram: be induced bytFe2: trigger-arg-path: Positive_regulation nn Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation agent Gene_or_gene_producttMe2: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='jnk1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] controllertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_producttSe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] controllert?e1: trigger-arg-path: mediated >nsubj [lemma='jnk1'] controllertde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] controllertTe1: trigger-arg-path: mediated >nsubj [lemma='jnk1'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_productthe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:mediated:Positive_regulation advcl [lemma='block'] e2:block:Negative_regulationt?shortest-path: advcl [lemma='block'] >nsubj [lemma='oligomer'] >nn [lemma='amyloid-beta']t]e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk1'] Gene_or_gene_producttctrigger-to-trigger-path: e1:mediated:Positive_regulation advcl e2:block:Negative_regulationtZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk1'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk1'] controllert.shortest-path: advcl >nsubj >nnt)shortest-path: conj_and >dobj >nntktrigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and >dobj e2:inhibition:Negative_regulationt?trigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and [lemma='suppress'] >dobj [lemma='inhibition'] e2:inhibition:Negative_regulationtxshortest-path: conj_and [lemma='suppress'] >dobj [lemma='inhibition'] >nn [lemma='calmodulin']t?trigger-to-trigger-path: e1:induced:Negative_regulation >ccomp [lemma='inhibit'] >dep [lemma='disperse'] >dobj [lemma='heterodimer'] e2:heterodimer:Bindingt+shortest-path: ccomp >dep >dobj >nnt?shortest-path: ccomp [lemma='inhibit'] >dep [lemma='disperse'] >dobj [lemma='heterodimer'] >nn [lemma='c-jun']t`trigger-to-trigger-path: e1:induced:Negative_regulation >ccomp >dep >dobj e2:heterodimer:BindingtOe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] controller:Familytnsubj [lemma='it'] theme:Generic_entityt]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] FamilytPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Generic_entitytHe1: trigger-arg-path: Binding >dobj [lemma='tip60'] Gene_or_gene_producttCe1: trigger-arg-path: bind >nsubj [lemma='it'] theme:Generic_entityt3e2: args2Role-mention-ngram: induced transformationt.e2: args2Role-mention-ngram: transformation byt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='tip60'] Gene_or_gene_producttnsubj [lemma='ra'] controllert4e1: trigger-arg-path: bind >nsubj [lemma='it'] themet;e2: ents2Label-mention-ngram: FAMILY induced transformationthe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] controller:FamilytKe1: trigger-arg-path: bind >dobj [lemma='tip60'] theme:Gene_or_gene_producttAe2: ents2Label-mention-ngram: degradation of GENE_OR_GENE_PRODUCTtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='tip60'] themetTe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] controller:Familyt-e2: ents2Label-mention-ngram: by facilitatingtBe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj Generic_entityt/e2: ents2Label-mention-ngram: transformation bytMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] controllert*e2: ents2Label-mention-ngram: facilitatingt0e1: trigger-arg-path: bind >nsubj Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] theme:Generic_entityt,e2: args2Role-mention-ngram: by facilitatingt>e1: trigger-arg-path: bind:Binding >nsubj theme:Generic_entityt5e1: ents2Label-mention-ngram: GENERIC_ENTITY can bindt>e2: args2Role-mention-ngram: CONTROLLER induced transformationt8e2: trigger-arg-path: induced >nsubj [lemma='ra'] Familytishortest-path: conj_and [lemma='induce'] >nsubj [lemma='ra']txtrigger-to-trigger-path: e1:bind:Binding conj_and [lemma='induce'] e2:induced:Positive_regulationtae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ra'] controllertWe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] controller:FamilytMe1: trigger-arg-path: bind:Binding >dobj [lemma='tip60'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Generic_entityt6e2: args2Role-mention-ngram: induced transformation byt1e2: ents2Label-mention-ngram: facilitating SHAREDt8e1: trigger-arg-path: bind:Binding >nsubj Generic_entityt>e1: trigger-arg-path: bind:Binding >dobj [lemma='tip60'] themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='tip60'] theme:Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj theme:Generic_entitytEe1: trigger-arg-path: bind:Binding >nsubj [lemma='it'] Generic_entityt,e2: ents2Label-mention-ngram: FAMILY inducedtHe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='tip60'] themetEe1: trigger-arg-path: bind >dobj [lemma='tip60'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: induced transformationt6e1: trigger-arg-path: bind >dobj [lemma='tip60'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='it'] Generic_entityt7e2: ents2Label-mention-ngram: induced transformation byt]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='tip60'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='it'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='tip60'] Gene_or_gene_producttKe1: trigger-arg-path: bind:Binding >nsubj [lemma='it'] theme:Generic_entitytSe1: trigger-arg-path: bind:Binding >dobj [lemma='tip60'] theme:Gene_or_gene_producttinterceding-token ngrams: blocktFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='it'] Generic_entitytnsubj [lemma='it'] themet=e1: trigger-arg-path: bind >nsubj [lemma='it'] Generic_entitytLe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] Familyt9e1: trigger-arg-path: Binding >dobj [lemma='tip60'] themetPe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ra'] controllert4e2: args2Role-mention-ngram: facilitating CONTROLLEDt)e2: args2Role-mention-ngram: facilitatingt;e2: args2Role-mention-ngram: transformation by facilitatingt=e2: ents2Label-mention-ngram: facilitating SHARED acetylationt7e2: args2Role-mention-ngram: by facilitating CONTROLLEDt'interceding-tokens-full-span: and blocktXtrigger-to-trigger-path: e1:bind:Binding conj_and e2:induced:Positive_regulationtIe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ra'] Familyt,e2: ents2Label-mention-ngram: transformationtDe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] FamilytHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ra'] controllertNe1: trigger-arg-path: Binding >dobj [lemma='tip60'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: transformationtCe2: trigger-arg-path: induced >nsubj [lemma='ra'] controller:Familyt#interceding-token ngrams: and blocktJe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Generic_entityt0e1: ents2Label-mention-ngram: GENERIC_ENTITY cantXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] themetae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] Gene_or_gene_producttntrigger-to-trigger-path: e1:binding:Binding nsubj [lemma='a-raf'] theme:Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttOe2: trigger-arg-path: binds:Binding >nsubj [lemma='a-raf'] Gene_or_gene_productt8e2: trigger-arg-path: binds >nsubj [lemma='a-raf'] themetOe2: trigger-arg-path: Binding >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] Gene_or_gene_productt9e2: trigger-arg-path: binds >prep_to [lemma='mst2'] themetNe2: trigger-arg-path: binds >prep_to [lemma='mst2'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a-raf'] Gene_or_gene_producttPe2: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a-raf'] themet@e2: trigger-arg-path: binds:Binding >nsubj [lemma='a-raf'] themetNtrigger-to-trigger-path: e1:binding:Binding nsubj [lemma='a-raf'] themet;e2: trigger-arg-path: Binding >prep_to [lemma='mst2'] themetGe2: trigger-arg-path: binds >nsubj [lemma='a-raf'] Gene_or_gene_productt:e2: trigger-arg-path: Binding >nsubj [lemma='a-raf'] themetHe2: trigger-arg-path: binds >prep_to [lemma='mst2'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_to [lemma='mst2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mst2'] theme:Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='a-raf'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mst2'] themetAe2: trigger-arg-path: binds:Binding >prep_to [lemma='mst2'] themetMe2: trigger-arg-path: binds >nsubj [lemma='a-raf'] theme:Gene_or_gene_producttte1: trigger-arg-path: Positive_regulation nsubj [lemma='AMPK'] Gene_or_gene_producttae1: trigger-arg-path: directly:Positive_regulation nsubj controller:Gene_or_gene_producttMe1: trigger-arg-path: directly nsubj controller:Gene_or_gene_producttXe1: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_producttBe1: trigger-arg-path: directly nsubj Gene_or_gene_producttje1: trigger-arg-path: Positive_regulation nsubj [lemma='AMPK'] controllert_e1: trigger-arg-path: directly nsubj [lemma='AMPK'] controllert8e1: trigger-arg-path: directly nsubj controllert?e1: trigger-arg-path: lemmatizedTrigger=directly nsubj [lemma='AMPK'] controller:Gene_or_gene_productt?e1: trigger-arg-path: directly:Positive_regulation nsubj [lemma='AMPK'] controller:Gene_or_gene_producttie1: trigger-arg-path: directly nsubj [lemma='AMPK'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=directly nsubj [lemma='AMPK'] Gene_or_gene_producttLe1: trigger-arg-path: directly:Positive_regulation nsubj controllertqtrigger-to-trigger-path: e1:directly:Positive_regulation dobj >prep_in >vmod >prep_to e2:binding:BindingtMe1: trigger-arg-path: Positive_regulation nsubj Gene_or_gene_producttse1: trigger-arg-path: directly:Positive_regulation nsubj [lemma='AMPK'] controllerte1: trigger-arg-path: Positive_regulation nsubj [lemma='AMPK'] controller:Gene_or_gene_productt?trigger-to-trigger-path: e1:directly:Positive_regulation dobj [lemma='Raptor'] >prep_in [lemma='manner'] >vmod [lemma='lead'] >prep_to [lemma='binding'] e2:binding:Bindingtse1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj controller:Gene_or_gene_productt}e1: trigger-arg-path: directly:Positive_regulation nsubj [lemma='AMPK'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='AMPK'] controllertJe1: trigger-arg-path: lemmatizedTrigger=directly nsubj controllertVe1: trigger-arg-path: directly:Positive_regulation nsubj Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj controllertqe1: trigger-arg-path: lemmatizedTrigger=directly nsubj [lemma='AMPK'] controllertte1: trigger-arg-path: directly nsubj [lemma='AMPK'] controller:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=directly nsubj Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='AMPK'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=directly nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='AMPK'] controller:Gene_or_gene_producttCe1: trigger-arg-path: Positive_regulation nsubj controllertce2: trigger-arg-path: raise:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controllert*e2: ents2Label-mention-ngram: hydrolysis ,t$e1: ents2Label-mention-ngram: of GTPtSe1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp controlledt+e1: ents2Label-mention-ngram: function , ortNe2: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] controlledt?e2: trigger-arg-path: raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controllertXe2: trigger-arg-path: raise:Negative_regulation >ccomp [lemma='bind'] controlled:BindingtNe1: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp [lemma='bind'] BindingtHe2: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn controllert/e2: args2Role-mention-ngram: hydrolysis , mightt#e1: args2Role-mention-ngram: levelst'e1: args2Role-mention-ngram: function ,t1e1: args2Role-mention-ngram: levels of CONTROLLEDt#e1: ents2Label-mention-ngram: raiset(e1: ents2Label-mention-ngram: the levelstGe2: trigger-arg-path: lemmatizedTrigger=raise >ccomp controlled:Bindingt#e1: args2Role-mention-ngram: of GTPt"e1: args2Role-mention-ngram: raisetKe1: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] Bindingtje2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_producttccomp [lemma='bind'] controlledt?e1: trigger-arg-path: raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controller:Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: the levels oft5e2: trigger-arg-path: raise >ccomp controlled:Bindingt*e1: args2Role-mention-ngram: inhibition oft.e1: args2Role-mention-ngram: of GTP hydrolysist4e2: args2Role-mention-ngram: CONTROLLER hydrolysis ,tDe2: trigger-arg-path: raise >nsubj >prep_of >nn Gene_or_gene_productt(e1: ents2Label-mention-ngram: function ,t+e1: ents2Label-mention-ngram: or inhibitiont-e1: args2Role-mention-ngram: raise the levelstOe1: trigger-arg-path: raise >nsubj >prep_of >nn controller:Gene_or_gene_producttce1: trigger-arg-path: raise:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_producttccomp BindingtRe2: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: might raisetue2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] BindingtXe1: trigger-arg-path: raise:Positive_regulation >ccomp [lemma='bind'] controlled:Bindingt$e2: args2Role-mention-ngram: , mighttae2: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn controller:Gene_or_gene_productt?shortest-path: conj_or [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp']tue1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: the levelst/e1: ents2Label-mention-ngram: inhibition of GTPtOe2: trigger-arg-path: raise >nsubj >prep_of >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: levels of SHAREDtNe2: trigger-arg-path: raise:Negative_regulation >nsubj >prep_of >nn controllertNe1: trigger-arg-path: raise:Positive_regulation >nsubj >prep_of >nn controllert,e1: args2Role-mention-ngram: might raise thet?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT hydrolysis ,t-e2: ents2Label-mention-ngram: might raise thet?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: raiset?e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controllert~e1: trigger-arg-path: raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controllertAe1: trigger-arg-path: raise:Positive_regulation >ccomp controlledt?e1: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] Gene_or_gene_productt&e2: args2Role-mention-ngram: raise thetPe2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp Bindingt]e2: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt1shortest-path: conj_or >prep_of >nnt'e2: ents2Label-mention-ngram: raise thet&e1: args2Role-mention-ngram: raise thet#e2: ents2Label-mention-ngram: raisetPe2: trigger-arg-path: raise:Negative_regulation >ccomp [lemma='bind'] controlledtLe2: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn controllertDe1: trigger-arg-path: raise >ccomp [lemma='bind'] controlled:BindingtPe1: trigger-arg-path: raise:Positive_regulation >ccomp [lemma='bind'] controlledt9e1: trigger-arg-path: raise >ccomp [lemma='bind'] Bindingt1e2: args2Role-mention-ngram: levels of CONTROLLEDt"e1: args2Role-mention-ngram: mighttDe2: trigger-arg-path: raise >ccomp [lemma='bind'] controlled:Bindingt*e1: args2Role-mention-ngram: , might raiset#e1: ents2Label-mention-ngram: mightt?e2: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] Gene_or_gene_producttIe1: trigger-arg-path: raise:Positive_regulation >ccomp controlled:Bindingt.e1: ents2Label-mention-ngram: GTP hydrolysis ,t,e2: args2Role-mention-ngram: might raise thetPe1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp Bindingt,e1: args2Role-mention-ngram: , or inhibitiont'e2: ents2Label-mention-ngram: levels oft&e1: args2Role-mention-ngram: levels oft&e2: args2Role-mention-ngram: levels oft%e1: args2Role-mention-ngram: functiont*e1: args2Role-mention-ngram: function , ort)e2: args2Role-mention-ngram: hydrolysis ,t.e2: ents2Label-mention-ngram: raise the levelst=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT hydrolysist*e2: args2Role-mention-ngram: , might raiset:e1: trigger-arg-path: raise >nsubj >prep_of >nn controllertAe2: trigger-arg-path: raise:Negative_regulation >ccomp controlledtSe2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp controlledt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT functiont?e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controllertVe1: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn Gene_or_gene_producttCe2: trigger-arg-path: Negative_regulation >ccomp controlled:Bindingt/e1: args2Role-mention-ngram: hydrolysis , mighttje1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_productt&e1: ents2Label-mention-ngram: functiont0e1: args2Role-mention-ngram: CONTROLLER functiontje2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp [lemma='bind'] controlled:Bindingt*e1: args2Role-mention-ngram: the levels oft8e2: trigger-arg-path: Negative_regulation >ccomp Bindingt?e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] Gene_or_gene_productt-e2: trigger-arg-path: raise >ccomp controlledtje1: trigger-arg-path: raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controllert2e1: args2Role-mention-ngram: CONTROLLER function ,te1: trigger-arg-path: raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controller:Gene_or_gene_producttccomp Bindingt*e1: args2Role-mention-ngram: or inhibitiont*e2: args2Role-mention-ngram: the levels oftRe2: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] controlled:Bindingt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT function ,tVe2: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controller:Gene_or_gene_productt9e2: trigger-arg-path: raise >ccomp [lemma='bind'] Bindingt?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] Gene_or_gene_productt"e2: args2Role-mention-ngram: mightt/e1: ents2Label-mention-ngram: of GTP hydrolysist-e1: ents2Label-mention-ngram: might raise thet?e2: trigger-arg-path: raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] Gene_or_gene_productt'e2: args2Role-mention-ngram: hydrolysist#e2: ents2Label-mention-ngram: mightt_e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp [lemma='bind'] BindingtLe1: trigger-arg-path: lemmatizedTrigger=raise >nsubj >prep_of >nn controllert-e1: args2Role-mention-ngram: GTP hydrolysis ,tGe2: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=raise >ccomp controlledt?e2: trigger-arg-path: lemmatizedTrigger=raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controllert+e2: ents2Label-mention-ngram: , might raiset'e1: ents2Label-mention-ngram: raise thet.e1: ents2Label-mention-ngram: or inhibition ofte1: trigger: raisetbe1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp [lemma='bind'] controlledt+e1: ents2Label-mention-ngram: inhibition oft'e1: ents2Label-mention-ngram: levels oft)e2: ents2Label-mention-ngram: might raiset0e1: ents2Label-mention-ngram: hydrolysis , mightt)e1: args2Role-mention-ngram: hydrolysis ,te2: trigger: raiset-e1: ents2Label-mention-ngram: , or inhibitiont?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controllert>e1: trigger-arg-path: raise:Positive_regulation >ccomp BindingtMe1: trigger-arg-path: raise:Positive_regulation >ccomp [lemma='bind'] BindingtVe1: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] controlled:Bindingt5e1: trigger-arg-path: raise >ccomp controlled:Bindingt[e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp controlled:Bindingt+e2: ents2Label-mention-ngram: the levels oftXe2: trigger-arg-path: raise:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >ccomp [lemma='bind'] controlled:Bindingt.e2: ents2Label-mention-ngram: levels of SHAREDt.e1: args2Role-mention-ngram: inhibition of GTPtccomp [lemma='bind'] controlledt*e1: trigger-arg-path: raise >ccomp Bindingtbe2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp [lemma='bind'] controlledt(e2: ents2Label-mention-ngram: the levelst%e2: ents2Label-mention-ngram: , mightt-e1: trigger-arg-path: raise >ccomp controlledt?e1: trigger-arg-path: raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] Gene_or_gene_producttMe2: trigger-arg-path: raise:Negative_regulation >ccomp [lemma='bind'] Bindingtte1: trigger-arg-path: raise >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=raise >ccomp [lemma='bind'] controlled:Bindingt`e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj >prep_of >nn controllert|e2: trigger-arg-path: raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] Gene_or_gene_producttre2: trigger-arg-path: raise >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controllertxe1: trigger-arg-path: Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controllert-e2: args2Role-mention-ngram: raise the levelstGe1: trigger-arg-path: lemmatizedTrigger=raise >ccomp controlled:Bindingt*e2: trigger-arg-path: raise >ccomp Bindingt-e2: ents2Label-mention-ngram: of SHARED boundt'e2: args2Role-mention-ngram: the levelst?e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='hydrolysis'] >nn [lemma='gtp'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: or inhibition oftDe1: trigger-arg-path: raise >nsubj >prep_of >nn Gene_or_gene_productt.e1: ents2Label-mention-ngram: raise the levelst?e2: trigger-arg-path: lemmatizedTrigger=raise >ccomp controlledt:e2: trigger-arg-path: raise >nsubj >prep_of >nn controllert`e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >nsubj >prep_of >nn controllert2e2: args2Role-mention-ngram: CONTROLLER hydrolysist)e1: ents2Label-mention-ngram: might raisetIe2: trigger-arg-path: raise:Negative_regulation >ccomp controlled:BindingtXe1: trigger-arg-path: raise:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_productt(e2: args2Role-mention-ngram: might raiset0e2: ents2Label-mention-ngram: hydrolysis , mightt*e1: ents2Label-mention-ngram: hydrolysis ,t[e2: trigger-arg-path: lemmatizedTrigger=raise:Negative_regulation >ccomp controlled:Bindingt>e2: trigger-arg-path: raise:Negative_regulation >ccomp Bindingt%e1: ents2Label-mention-ngram: , mightt?e1: trigger-arg-path: lemmatizedTrigger=raise:Positive_regulation >nsubj [lemma='loss'] >prep_of [lemma='function'] >nn [lemma='gap'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: , mightt+e1: ents2Label-mention-ngram: , might raisetJe2: trigger-arg-path: Negative_regulation >ccomp [lemma='bind'] controlledtke2: trigger-arg-path: Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] theme:Gene_or_gene_producttse2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='xiap'] themetCe2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] themet*e1: ents2Label-mention-ngram: protein XIAPtVe2: trigger-arg-path: Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] themetJe2: trigger-arg-path: Binding >prep_of [lemma='xiap'] Gene_or_gene_producttme2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] themet,e1: ents2Label-mention-ngram: protein XIAP (t?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj [lemma='protein'] >vmod [lemma='result'] >prep_in [lemma='increase'] >prep_of [lemma='binding'] e2:binding:Bindingt^e2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] themetwe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] theme:Gene_or_gene_productt;e2: trigger-arg-path: binding >prep_of [lemma='xiap'] themetotrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >dobj >vmod >prep_in >prep_of e2:binding:Bindingt(interceding-token ngrams: in an increaset*e1: ents2Label-mention-ngram: pro-survivaltXe2: trigger-arg-path: binding:Binding >prep_of [lemma='xiap'] theme:Gene_or_gene_productt)interceding-token ngrams: resulting in antVe2: trigger-arg-path: binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] themet8e1: ents2Label-mention-ngram: and activates pro-survivalt2e1: ents2Label-mention-ngram: pro-survival proteintMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] themetPe2: trigger-arg-path: Binding >prep_of [lemma='xiap'] theme:Gene_or_gene_producttee2: trigger-arg-path: binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] Gene_or_gene_productt'interceding-token ngrams: ) , resultingtke2: trigger-arg-path: binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] theme:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] theme:Gene_or_gene_producttJe2: trigger-arg-path: binding >prep_of [lemma='xiap'] Gene_or_gene_productt=interceding-tokens-full-span: ) , resulting in an increase oft;e2: trigger-arg-path: Binding >prep_of [lemma='xiap'] themet&e1: ents2Label-mention-ngram: ( SHAREDt$e1: ents2Label-mention-ngram: XIAP (tprep_of [lemma='xiap'] theme:Gene_or_gene_productt%interceding-token ngrams: increase oft%interceding-token ngrams: , resultingt3shortest-path: dobj >vmod >prep_in >prep_oft"e1: ents2Label-mention-ngram: XIAPt%interceding-token ngrams: an increasete2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: activates pro-survivaltPe2: trigger-arg-path: binding >prep_of [lemma='xiap'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='xiap'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: XIAP ( SHAREDt7e1: ents2Label-mention-ngram: pro-survival protein XIAPtee2: trigger-arg-path: Binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='xiap'] >prep_to [lemma='caspase'] themet?shortest-path: dobj [lemma='protein'] >vmod [lemma='result'] >prep_in [lemma='increase'] >prep_of [lemma='binding']t(interceding-token ngrams: , resulting int(interceding-token ngrams: an increase oft8e2: trigger-arg-path: Binding >dobj [lemma='Rheb'] themetge2: trigger-arg-path: Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] theme:Gene_or_gene_producttPtrigger-to-trigger-path: e1:releases:Negative_regulation >ccomp e2:bound:BindingtRe1: trigger-arg-path: releases >nsubj >prep_of >nn controller:Gene_or_gene_productte1: trigger: releasest/e1: args2Role-mention-ngram: CONTROLLER complext6e2: trigger-arg-path: bound >dobj [lemma='Rheb'] themetMe2: trigger-arg-path: bound:Binding >dobj [lemma='Rheb'] Gene_or_gene_producttge2: trigger-arg-path: bound:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='Rheb'] themet.e1: args2Role-mention-ngram: inhibitory effecttNe1: trigger-arg-path: lemmatizedTrigger=release >nsubj >prep_of >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] Gene_or_gene_productt#e1: args2Role-mention-ngram: effectt.e1: ents2Label-mention-ngram: complex releasestie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] themet9shortest-path: ccomp >nsubj >prep_oft?e1: trigger-arg-path: lemmatizedTrigger=release >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controllert]e1: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: THEME ont?e1: trigger-arg-path: lemmatizedTrigger=release >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: inhibitory effect oft4e1: args2Role-mention-ngram: releases the inhibitorytQe1: trigger-arg-path: releases:Negative_regulation >nsubj >prep_of >nn controllert+e1: args2Role-mention-ngram: the inhibitorytMe2: trigger-arg-path: Binding >dobj [lemma='Rheb'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controllert?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_productte2: args2Role-mention-ngram: ont3e1: ents2Label-mention-ngram: the inhibitory effecttXe1: trigger-arg-path: lemmatizedTrigger=release >nsubj >prep_of >nn Gene_or_gene_productt+e1: ents2Label-mention-ngram: SHARED on thetHe1: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn controllertRe2: trigger-arg-path: Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] themet-e1: args2Role-mention-ngram: complex releasest)e2: args2Role-mention-ngram: THEME on thetfe1: trigger-arg-path: releases:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: on the GTPt?e1: trigger-arg-path: releases:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] Gene_or_gene_productt2e1: args2Role-mention-ngram: the inhibitory effecttGe2: trigger-arg-path: Binding >dobj [lemma='Rheb'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='Rheb'] Gene_or_gene_productt?e1: trigger-arg-path: releases >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controller:Gene_or_gene_producttXe2: trigger-arg-path: bound:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] themet5e1: ents2Label-mention-ngram: SHARED complex releasestee2: trigger-arg-path: bound >nsubj [lemma='effect'] >prep_of [lemma='TSC'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: on the GTPtpe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='effect'] >prep_of [lemma='TSC'] Gene_or_gene_productt)e1: args2Role-mention-ngram: releases thetEe2: trigger-arg-path: bound >dobj [lemma='Rheb'] Gene_or_gene_productt?e1: trigger-arg-path: releases:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controllert1e1: args2Role-mention-ngram: effect of CONTROLLEDt$e1: ents2Label-mention-ngram: on thetme2: trigger-arg-path: bound:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: inhibitory effecttVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='Rheb'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=release >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] Gene_or_gene_productt8e1: args2Role-mention-ngram: CONTROLLER complex releasest,e1: ents2Label-mention-ngram: the inhibitoryt.e1: ents2Label-mention-ngram: GTP bound SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] theme:Gene_or_gene_productt}e1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controllert5e1: ents2Label-mention-ngram: releases the inhibitoryt&e1: args2Role-mention-ngram: effect oft%e1: args2Role-mention-ngram: releasestRe1: trigger-arg-path: Negative_regulation >nsubj >prep_of >nn Gene_or_gene_productt$e2: ents2Label-mention-ngram: on thet*e1: ents2Label-mention-ngram: releases thet(e1: ents2Label-mention-ngram: on the GTPtGe1: trigger-arg-path: releases >nsubj >prep_of >nn Gene_or_gene_producttSe2: trigger-arg-path: bound:Binding >dobj [lemma='Rheb'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=release >nsubj >prep_of >nn controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: inhibitory effect oft&e1: ents2Label-mention-ngram: releasestve2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='effect'] >prep_of [lemma='TSC'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: complex releases thet>e2: trigger-arg-path: bound:Binding >dobj [lemma='Rheb'] themetxe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='effect'] >prep_of [lemma='TSC'] themetae2: trigger-arg-path: Binding >nsubj [lemma='effect'] >prep_of [lemma='TSC'] Gene_or_gene_producttKe2: trigger-arg-path: bound >dobj [lemma='Rheb'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=release:Negative_regulation >nsubj >prep_of >nn controllert'e1: args2Role-mention-ngram: inhibitoryt$e1: ents2Label-mention-ngram: effectt_trigger-to-trigger-path: e1:releases:Negative_regulation >ccomp [lemma='bind'] e2:bound:Bindingt'e1: ents2Label-mention-ngram: effect oft[e1: trigger-arg-path: releases:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='Rheb'] theme:Gene_or_gene_productt?e1: trigger-arg-path: releases:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controller:Gene_or_gene_producttre1: trigger-arg-path: releases >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] controllert(e1: ents2Label-mention-ngram: inhibitoryt.e1: ents2Label-mention-ngram: effect of SHAREDt_e2: trigger-arg-path: bound >nsubj [lemma='effect'] >prep_of [lemma='TSC'] Gene_or_gene_productt|e1: trigger-arg-path: releases >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] Gene_or_gene_producttPe2: trigger-arg-path: bound >nsubj [lemma='effect'] >prep_of [lemma='TSC'] themet=e1: trigger-arg-path: releases >nsubj >prep_of >nn controllertOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='Rheb'] themet+e2: ents2Label-mention-ngram: SHARED on thet#e2: args2Role-mention-ngram: on thet?shortest-path: ccomp [lemma='bind'] >nsubj [lemma='effect'] >prep_of [lemma='TSC']t1e1: args2Role-mention-ngram: complex releases thet?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='complex'] >nn [lemma='tsc'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='Rheb'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=prevent dobj controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='association'] controlled:Generic_eventtde2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='association'] controlled:Generic_eventtdobj controlled:Generic_eventt(e2: ents2Label-mention-ngram: Ser536 andt?e2: trigger-arg-path: lemmatizedTrigger=prevent dobj [lemma='p65'] controllert3e2: ents2Label-mention-ngram: chromatin associationtGe2: trigger-arg-path: prevent >dobj [lemma='association'] Generic_eventtCe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj Generic_eventtVe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='association'] controlledtdobj Gene_or_gene_productt(e2: args2Role-mention-ngram: prevent thet?interceding-tokens-full-span: complex almost immediately after the active p50-RelA and p65 heterodimer binds to the promoter , IKKalpha remains associated with the chromatin and phosphorylates botht6e2: args2Role-mention-ngram: recruitment and chromatint!e2: args2Role-mention-ngram: SMRTt-e2: ents2Label-mention-ngram: Ser536 and SMRTtbe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj controlled:Generic_eventtce2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj controllert-e2: ents2Label-mention-ngram: the recruitmentt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj [lemma='p65'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent dobj [lemma='p65'] controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj controlledt#e2: args2Role-mention-ngram: Ser536t1e2: args2Role-mention-ngram: CONTROLLER at Ser536tQe2: trigger-arg-path: prevent:Negative_regulation dobj controllert7e2: ents2Label-mention-ngram: and chromatin associationt?e2: trigger-arg-path: prevent dobj [lemma='p65'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: Ser536 and SMRTtXe2: trigger-arg-path: prevent:Negative_regulation >dobj [lemma='association'] controlledtRe2: trigger-arg-path: prevent >dobj [lemma='association'] controlled:Generic_eventt7e2: ents2Label-mention-ngram: recruitment and chromatintme2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj Gene_or_gene_productt1e2: args2Role-mention-ngram: chromatin CONTROLLEDt5e2: ents2Label-mention-ngram: prevent the recruitmenttze2: trigger-arg-path: Negative_regulation dobj [lemma='p65'] controllert,e2: args2Role-mention-ngram: the recruitmentt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj [lemma='p65'] controllertSe2: trigger-arg-path: Negative_regulation dobj Gene_or_gene_producttSe2: trigger-arg-path: Negative_regulation >dobj [lemma='association'] Generic_eventtIe2: trigger-arg-path: Negative_regulation dobj controllert%e2: ents2Label-mention-ngram: Ser2410tNe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlled:Generic_eventt0e2: ents2Label-mention-ngram: Ser2410 to preventtYe2: trigger-arg-path: lemmatizedTrigger=prevent dobj Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='association'] Generic_eventt^trigger-to-trigger-path: e1:bound:Binding prep_at >vmod e2:prevent:Negative_regulationtEe2: trigger-arg-path: prevent:Negative_regulation >dobj Generic_eventtme2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='association'] Generic_eventt?e2: trigger-arg-path: prevent:Negative_regulation dobj [lemma='p65'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: Ser2410 to preventtOe2: trigger-arg-path: lemmatizedTrigger=prevent dobj controllert*e2: args2Role-mention-ngram: at Ser2410 tot,e2: ents2Label-mention-ngram: to prevent thet+e2: args2Role-mention-ngram: to prevent thetRe2: trigger-arg-path: prevent dobj controller:Gene_or_gene_productt&shortest-path: dobjt?trigger-to-trigger-path: e1:bound:Binding prep_at [lemma='ser2410'] >vmod [lemma='prevent'] e2:prevent:Negative_regulationt)e2: ents2Label-mention-ngram: and SMRT attBe2: trigger-arg-path: prevent:Negative_regulation >dobj controlledt$e2: args2Role-mention-ngram: Ser2410t%e2: args2Role-mention-ngram: and SMRTt1e2: ents2Label-mention-ngram: the recruitment andt%e2: ents2Label-mention-ngram: SMRT att?e2: trigger-arg-path: lemmatizedTrigger=prevent dobj [lemma='p65'] Gene_or_gene_productt=e2: trigger-arg-path: prevent dobj controllert*e2: args2Role-mention-ngram: at Ser536 andtje2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='association'] controlledt"e2: ents2Label-mention-ngram: SMRTt'e2: ents2Label-mention-ngram: at Ser536t5e2: args2Role-mention-ngram: and chromatin CONTROLLEDt-e2: ents2Label-mention-ngram: SMRT at Ser2410t&e2: args2Role-mention-ngram: at Ser536tWe2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj Generic_eventtPe2: trigger-arg-path: prevent:Negative_regulation >dobj controlled:Generic_eventtfe2: trigger-arg-path: prevent:Negative_regulation dobj controller:Gene_or_gene_producttfe2: trigger-arg-path: prevent:Negative_regulation >dobj [lemma='association'] controlled:Generic_eventtDe2: trigger-arg-path: prevent >dobj [lemma='association'] controlledtPe2: trigger-arg-path: Negative_regulation >dobj [lemma='association'] controlledt+e2: ents2Label-mention-ngram: at Ser2410 tot5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT att[e2: trigger-arg-path: prevent:Negative_regulation dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation dobj [lemma='p65'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and SMRTt,e2: args2Role-mention-ngram: SMRT at Ser2410txe2: trigger-arg-path: prevent dobj [lemma='p65'] Gene_or_gene_productt[e2: trigger-arg-path: prevent:Negative_regulation >dobj [lemma='association'] Generic_eventt(e2: args2Role-mention-ngram: and SMRT att*e2: args2Role-mention-ngram: and chromatint+e2: ents2Label-mention-ngram: at Ser536 andt?e2: trigger-arg-path: prevent:Negative_regulation dobj [lemma='p65'] Gene_or_gene_productt?e2: trigger-arg-path: Negative_regulation dobj [lemma='p65'] Gene_or_gene_productt^e2: trigger-arg-path: Negative_regulation >dobj [lemma='association'] controlled:Generic_eventt?e2: trigger-arg-path: Negative_regulation dobj [lemma='p65'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: at Ser2410t1e2: trigger-arg-path: prevent >dobj Generic_eventt0e2: args2Role-mention-ngram: the recruitment andtne2: trigger-arg-path: prevent dobj [lemma='p65'] controllert.e2: trigger-arg-path: prevent >dobj controlledt(e2: ents2Label-mention-ngram: Ser2410 tot'e2: args2Role-mention-ngram: at Ser2410teshortest-path: dobj [lemma='p65']t)e2: ents2Label-mention-ngram: prevent thet?e2: trigger-arg-path: prevent:Negative_regulation dobj [lemma='p65'] controllert4e2: args2Role-mention-ngram: prevent the recruitmentt'e2: args2Role-mention-ngram: Ser2410 tot+e2: ents2Label-mention-ngram: and chromatint$e2: args2Role-mention-ngram: SMRT att^e2: trigger-arg-path: Negative_regulation dobj controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: Ser536tBe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn controllert/e1: ents2Label-mention-ngram: and production oft)shortest-path: nsubjtGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IRS'] themet&e2: args2Role-mention-ngram: GAB1 bindtIe1: trigger-arg-path: stimulation:Positive_activation >prep_of controlledtMe1: trigger-arg-path: stimulation >prep_of [lemma='pip'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: and productiont?e1: trigger-arg-path: stimulation >nn [lemma='pi3k'] controllertGe1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of controlledt'e2: ents2Label-mention-ngram: GAB1 bindt=e2: trigger-arg-path: bind:Binding >nsubj [lemma='IRS'] themetLe2: trigger-arg-path: bind:Binding >nsubj [lemma='IRS'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of [lemma='pip'] controlled:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IRS'] themetIe1: trigger-arg-path: stimulation >nn [lemma='pi3k'] Gene_or_gene_productt5e2: trigger-arg-path: bind >nsubj [lemma='IRS'] themetdobj [lemma='pip'] themet:e1: trigger-arg-path: stimulation >nn Gene_or_gene_producttCe2: trigger-arg-path: bind >dobj [lemma='pip'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pip'] Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='IRS'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >prep_of [lemma='pip'] Gene_or_gene_producttjtrigger-to-trigger-path: e1:stimulation:Positive_activation prep_of [lemma='pip'] controlledt8e2: trigger-arg-path: Binding >nsubj [lemma='IRS'] themet5e1: trigger-arg-path: stimulation >prep_of controlledtLe2: trigger-arg-path: Binding >dobj [lemma='pip'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn Gene_or_gene_productt%e2: args2Role-mention-ngram: and GAB1t8e1: ents2Label-mention-ngram: stimulation and productiont"e2: ents2Label-mention-ngram: GAB1tSe1: trigger-arg-path: stimulation:Positive_activation >prep_of Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='pi3k'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >prep_of Gene_or_gene_producttCe1: trigger-arg-path: stimulation >prep_of [lemma='pip'] controlledtVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IRS'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn Gene_or_gene_productt.e2: ents2Label-mention-ngram: GAB1 bind SHAREDtUe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pip'] Gene_or_gene_productt5e1: args2Role-mention-ngram: production of CONTROLLEDtYe1: trigger-arg-path: stimulation:Positive_activation >nn controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IRS'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >dobj [lemma='pip'] Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and GAB1t2e1: ents2Label-mention-ngram: production of SHAREDtQe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='pi3k'] controllert+e2: args2Role-mention-ngram: THEME and GAB1t*e2: args2Role-mention-ngram: and GAB1 bindt*e1: args2Role-mention-ngram: production oft-e1: ents2Label-mention-ngram: stimulation andtKe1: trigger-arg-path: Positive_activation >prep_of [lemma='pip'] controlledt,e2: args2Role-mention-ngram: GAB1 bind THEMEt&e2: ents2Label-mention-ngram: and GAB1t4e2: trigger-arg-path: bind >dobj [lemma='pip'] themet[trigger-to-trigger-path: e1:stimulation:Positive_activation prep_of controlledtfe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='pi3k'] controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pip'] theme:Gene_or_gene_productt?e1: trigger-arg-path: stimulation >prep_of Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IRS'] theme:Gene_or_gene_producttKe2: trigger-arg-path: bind:Binding >dobj [lemma='pip'] Gene_or_gene_producttGe1: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] controllertIe2: trigger-arg-path: bind >dobj [lemma='pip'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn controllertBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation andt`e1: trigger-arg-path: Positive_activation >prep_of [lemma='pip'] controlled:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pip'] themet\e1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IRS'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubj [lemma='IRS'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: and GAB1 bindtJe2: trigger-arg-path: bind >nsubj [lemma='IRS'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='pi3k'] Gene_or_gene_producttXe1: trigger-arg-path: stimulation >prep_of [lemma='pip'] controlled:Gene_or_gene_productt.e1: args2Role-mention-ngram: and production oftUe1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of [lemma='pip'] controlledt~e1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >prep_of [lemma='pip'] controlled:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn controller:Gene_or_gene_producttNe1: trigger-arg-path: stimulation:Positive_activation >nn Gene_or_gene_producttinterceding-token ngrams: 3 ,t[e1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='pi3k'] Gene_or_gene_productt+e1: args2Role-mention-ngram: and productiontae1: trigger-arg-path: stimulation:Positive_activation >prep_of [lemma='pip'] Gene_or_gene_productt!interceding-tokens-full-span: 3 ,tRe2: trigger-arg-path: bind:Binding >nsubj [lemma='IRS'] theme:Gene_or_gene_productt\shortest-path: nsubj [lemma='IRS']t^e1: trigger-arg-path: stimulation:Positive_activation >prep_of controlled:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of Gene_or_gene_productthe1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='pi3k'] controller:Gene_or_gene_producttJe1: trigger-arg-path: stimulation >prep_of controlled:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pip'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >prep_of [lemma='pip'] controlledt!e2: args2Role-mention-ngram: GAB1t7e1: args2Role-mention-ngram: CONTROLLER stimulation andt]e1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='pi3k'] Gene_or_gene_producttEe1: trigger-arg-path: stimulation >nn controller:Gene_or_gene_producttle1: trigger-arg-path: stimulation:Positive_activation >prep_of [lemma='pip'] controlled:Gene_or_gene_producttDe2: trigger-arg-path: bind >nsubj [lemma='IRS'] Gene_or_gene_producttSe1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='pi3k'] controllert0e1: trigger-arg-path: stimulation >nn controllertpe1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >prep_of controlled:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='pi3k'] controllertDe1: trigger-arg-path: stimulation:Positive_activation >nn controllertTe1: trigger-arg-path: stimulation >nn [lemma='pi3k'] controller:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pip'] themet'e1: args2Role-mention-ngram: productiont,e1: args2Role-mention-ngram: stimulation andtQe1: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] Gene_or_gene_producttUe1: trigger-arg-path: Positive_activation >prep_of [lemma='pip'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: productiont\e1: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] controller:Gene_or_gene_producttQe2: trigger-arg-path: bind:Binding >dobj [lemma='pip'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=stimulation >prep_of [lemma='pip'] Gene_or_gene_productt7e2: trigger-arg-path: Binding >dobj [lemma='pip'] themet+e1: ents2Label-mention-ngram: production oft7e1: args2Role-mention-ngram: stimulation and productiont-e1: trigger-arg-path: bound >prep_on >nn Sitet#e2: ents2Label-mention-ngram: on C6t?e2: ents2Label-mention-ngram: associate to GENE_OR_GENE_PRODUCTt,e2: args2Role-mention-ngram: on C6 membranest]e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_to theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=associate >prep_to Gene_or_gene_productt e2: ents2Label-mention-ngram: C6t5e1: trigger-arg-path: bound:Binding >prep_on >nn sitetTe1: trigger-arg-path: Binding >prep_to [lemma='receptor'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED bound tot/e2: args2Role-mention-ngram: still associate tot*e2: ents2Label-mention-ngram: associate totNe2: trigger-arg-path: associate >prep_to [lemma='nkr-p1'] Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_to [lemma='nkr-p1'] themete1: args2Role-mention-ngram: ontYe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_to [lemma='nkr-p1'] themet?e1: trigger-arg-path: Binding >prep_to [lemma='receptor'] themetWe2: trigger-arg-path: associate:Binding >nsubj [lemma='ts4'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='receptor'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: receptor on C6tLe2: trigger-arg-path: Binding >prep_to [lemma='nkr-p1'] Gene_or_gene_productt2e2: args2Role-mention-ngram: membranes could stilltVe2: trigger-arg-path: associate:Binding >prep_to [lemma='nkr-p1'] Gene_or_gene_productt+e2: args2Role-mention-ngram: receptor on C6t@e2: trigger-arg-path: lemmatizedTrigger=associate >prep_to themetTe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='ts4'] themet/e1: trigger-arg-path: Binding >prep_on >nn sitetZe1: trigger-arg-path: bound:Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] site:Sitet[e1: trigger-arg-path: lemmatizedTrigger=bind e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj themetTe1: trigger-arg-path: bound:Binding >prep_to [lemma='receptor'] Gene_or_gene_productt=e1: trigger-arg-path: bound >prep_to [lemma='receptor'] themetFe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_on >nn sitetUe1: trigger-arg-path: bound:Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] sitet.e2: trigger-arg-path: associate >prep_to themet*e2: ents2Label-mention-ngram: C6 membranest>e1: trigger-arg-path: lemmatizedTrigger=bind >prep_on >nn sitetRe1: trigger-arg-path: bound >prep_to [lemma='receptor'] theme:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj themetOe2: trigger-arg-path: associate >nsubj [lemma='ts4'] theme:Gene_or_gene_producttCe2: trigger-arg-path: associate:Binding >nsubj Gene_or_gene_productt-e2: ents2Label-mention-ngram: still associatet4e1: trigger-arg-path: Binding >prep_on >nn site:SitetUe2: trigger-arg-path: lemmatizedTrigger=associate >prep_to theme:Gene_or_gene_producttCe2: trigger-arg-path: associate >prep_to theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: on SITEt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_on [lemma='membrane'] >nn [lemma='c6'] sitetae2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='ts4'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_on [lemma='membrane'] >nn [lemma='c6'] sitet6e2: trigger-arg-path: associate:Binding >prep_to themetEe1: trigger-arg-path: bound:Binding >prep_to [lemma='receptor'] themet3e2: ents2Label-mention-ngram: could still associatetLe1: trigger-arg-path: Binding prep_to [lemma='receptor'] Gene_or_gene_productt)e2: args2Role-mention-ngram: associate tot-e2: ents2Label-mention-ngram: lectin receptort(e1: args2Role-mention-ngram: to THEME ont$e2: ents2Label-mention-ngram: lectintce1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='receptor'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: associate to THEMEtMe2: trigger-arg-path: Binding >nsubj [lemma='ts4'] theme:Gene_or_gene_producttUe1: trigger-arg-path: bound:Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] Sitet\e2: trigger-arg-path: associate:Binding >prep_to [lemma='nkr-p1'] theme:Gene_or_gene_productt>e1: trigger-arg-path: lemmatizedTrigger=bind >prep_on >nn SitetFe1: trigger-arg-path: Binding nsubj theme:Gene_or_gene_productt7e1: trigger-arg-path: Binding prep_to [lemma='nkr-p1'] themetAe2: trigger-arg-path: associate >nsubj theme:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_on >nn Sitetce2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='ts4'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='ts4'] Gene_or_gene_productt%e1: args2Role-mention-ngram: THEME ont5e1: trigger-arg-path: bound:Binding >prep_on >nn SitetLe1: trigger-arg-path: bound:Binding nsubj [lemma='ts4'] themetIe2: trigger-arg-path: associate >nsubj [lemma='ts4'] Gene_or_gene_productt,e2: args2Role-mention-ngram: lectin receptortUe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj Gene_or_gene_productt/e2: args2Role-mention-ngram: C6 membranes couldt,e2: args2Role-mention-ngram: membranes couldtKtrigger-to-trigger-path: e1:bound:Binding nsubj [lemma='ts4'] themet)e2: args2Role-mention-ngram: C6 membranest]e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='receptor'] Gene_or_gene_producttTe2: trigger-arg-path: associate >prep_to [lemma='nkr-p1'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: lectin receptor ontKe2: trigger-arg-path: associate:Binding >prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: associate >prep_to [lemma='nkr-p1'] themetJe1: trigger-arg-path: bound prep_on [lemma='membrane'] >nn [lemma='c6'] Sitet/e1: trigger-arg-path: Binding >prep_on >nn SitetNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='ts4'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='receptor'] Gene_or_gene_productt#e2: args2Role-mention-ngram: lectint0e2: ents2Label-mention-ngram: C6 membranes couldt;e1: ents2Label-mention-ngram: bound to GENE_OR_GENE_PRODUCTt-e2: ents2Label-mention-ngram: bound to lectintUe1: trigger-arg-path: lemmatizedTrigger=bind prep_to [lemma='nkr-p1'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: still associatet/e2: args2Role-mention-ngram: to lectin receptortZe1: trigger-arg-path: bound:Binding >prep_to [lemma='receptor'] theme:Gene_or_gene_producttRe1: trigger-arg-path: bound:Binding prep_on >nn site:Sitet-e1: trigger-arg-path: bound >prep_on >nn sitetFe1: trigger-arg-path: lemmatizedTrigger=bind prep_on [lemma='membrane'] >nn [lemma='c6'] Sitetie2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='ts4'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: lectin receptor ontTe1: trigger-arg-path: Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] site:SitetNe1: trigger-arg-path: Binding >prep_to [lemma='receptor'] Gene_or_gene_productt,e2: args2Role-mention-ngram: bound to lectint0e2: ents2Label-mention-ngram: to lectin receptort)e2: ents2Label-mention-ngram: receptor ontVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='receptor'] themethe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_to [lemma='nkr-p1'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: membranes could stillt5e1: trigger-arg-path: bound prep_on >nn site:Sitet&e2: args2Role-mention-ngram: membranestIe2: trigger-arg-path: associate:Binding >nsubj theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: to GENE_OR_GENE_PRODUCT ontOe1: trigger-arg-path: Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] sitet[e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: membranest#e1: ents2Label-mention-ngram: on C6t(e2: args2Role-mention-ngram: could stillt-e2: ents2Label-mention-ngram: SHARED bound totRe2: trigger-arg-path: Binding >prep_to [lemma='nkr-p1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=associate >prep_to [lemma='nkr-p1'] Gene_or_gene_producttGe2: trigger-arg-path: associate:Binding >prep_to [lemma='nkr-p1'] themetMe1: trigger-arg-path: bound >prep_on [lemma='membrane'] >nn [lemma='c6'] sitetHe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_to themetmtrigger-to-trigger-path: e1:bound:Binding prep_on >nn site:Sitet4e2: trigger-arg-path: associate:Binding >nsubj themet8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT on C6tGe2: trigger-arg-path: Binding >nsubj [lemma='ts4'] Gene_or_gene_productt:e2: trigger-arg-path: associate >nsubj [lemma='ts4'] themetDe1: trigger-arg-path: bound prep_to [lemma='receptor'] themetce1: trigger-arg-path: lemmatizedTrigger=bind >prep_on [lemma='membrane'] >nn [lemma='c6'] site:SitetWe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_to Gene_or_gene_productt e1: ents2Label-mention-ngram: C6tfe2: trigger-arg-path: lemmatizedTrigger=associate >prep_to [lemma='nkr-p1'] theme:Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=bind >prep_on >nn site:Sitet*e1: args2Role-mention-ngram: THEME on SITEtEe2: trigger-arg-path: associate:Binding >prep_to Gene_or_gene_productt-e2: ents2Label-mention-ngram: on C6 membranestke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] site:Sitet+e2: args2Role-mention-ngram: THEME bound tot,e2: trigger-arg-path: associate >nsubj themetOe1: trigger-arg-path: Binding >prep_on [lemma='membrane'] >nn [lemma='c6'] Sitete2: args2Role-mention-ngram: C6t(e2: args2Role-mention-ngram: receptor ontMe1: trigger-arg-path: bound >prep_on [lemma='membrane'] >nn [lemma='c6'] Sitet8e2: trigger-arg-path: Binding >nsubj [lemma='ts4'] themet=e1: trigger-arg-path: bound:Binding prep_to Gene_or_gene_productt"e2: args2Role-mention-ngram: on C6t2e2: args2Role-mention-ngram: could still associatetRe1: trigger-arg-path: bound >prep_on [lemma='membrane'] >nn [lemma='c6'] site:SitetJe1: trigger-arg-path: binding >prep_of [lemma='glus'] Gene_or_gene_producttBe1: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] themetUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] themetLe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] themet)e1: args2Role-mention-ngram: of activatedt1e1: args2Role-mention-ngram: binding of activatedtRe1: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] themet0e1: args2Role-mention-ngram: activated THEME andt:e1: trigger-arg-path: Binding >prep_of [lemma='jun'] themetPe1: trigger-arg-path: binding >prep_of [lemma='glus'] theme:Gene_or_gene_producttIe1: trigger-arg-path: binding >prep_of [lemma='jun'] Gene_or_gene_productt;e1: trigger-arg-path: binding >prep_of [lemma='glus'] themet1e1: ents2Label-mention-ngram: of activated SHAREDtIe1: trigger-arg-path: Binding >prep_of [lemma='jun'] Gene_or_gene_productt/e1: args2Role-mention-ngram: of activated THEMEtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='glus'] Gene_or_gene_productt|trigger-to-trigger-path: e1:binding:Binding >prep_of [lemma='jun'] >amod [lemma='activate'] e2:activated:Positive_activationtie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttQe1: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: of activatedtJe1: trigger-arg-path: Binding >prep_of [lemma='glus'] Gene_or_gene_producttCe1: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] themetXe1: trigger-arg-path: binding:Binding >prep_of [lemma='glus'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding >prep_of [lemma='jun'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_of [lemma='glus'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: binding of activatedt\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='glus'] Gene_or_gene_productt[trigger-to-trigger-path: e1:binding:Binding >prep_of >amod e2:activated:Positive_activationt,e1: args2Role-mention-ngram: activated THEMEtTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='jun'] themet[e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: activated SHARED andtae1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='jun'] theme:Gene_or_gene_productt:e1: trigger-arg-path: binding >prep_of [lemma='jun'] themetWe1: trigger-arg-path: binding:Binding >prep_of [lemma='jun'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_of [lemma='glus'] themet@e2: ents2Label-mention-ngram: histone acetyltransferase activitytFe1: trigger-arg-path: suppresses:Negative_regulation >nsubj controllertBe1: trigger-arg-path: suppresses >nsubj controller:Simple_chemicaltccomp Positive_regulationt1e1: ents2Label-mention-ngram: activity and SHAREDt,e2: ents2Label-mention-ngram: SHARED histonet1e1: args2Role-mention-ngram: also suppresses p300tfe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='melatonin'] controller:Simple_chemicalt8e1: ents2Label-mention-ngram: acetyltransferase activityt2e1: trigger-arg-path: suppresses >ccomp controlledt-e1: ents2Label-mention-ngram: also suppressestae1: trigger-arg-path: suppresses:Negative_regulation >ccomp [lemma='mediate'] Positive_regulationtMe1: trigger-arg-path: suppresses >ccomp [lemma='mediate'] Positive_regulationt.e2: args2Role-mention-ngram: acetyltransferaset*e1: ents2Label-mention-ngram: p300 histonet[e1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='melatonin'] Simple_chemicalt5e1: ents2Label-mention-ngram: suppresses p300 histonetje1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='melatonin'] controllert@e1: ents2Label-mention-ngram: histone acetyltransferase activitytFe1: trigger-arg-path: suppresses >nsubj [lemma='melatonin'] controllert1e1: ents2Label-mention-ngram: and SHARED mediatedtze1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='melatonin'] controller:Simple_chemicaltZe1: trigger-arg-path: suppresses:Negative_regulation >nsubj [lemma='melatonin'] controllertatrigger-to-trigger-path: e1:suppresses:Negative_regulation >ccomp e2:mediated:Positive_regulationt,e1: args2Role-mention-ngram: suppresses p300t6e2: args2Role-mention-ngram: histone acetyltransferasetccomp Positive_regulationt/e2: ents2Label-mention-ngram: acetyltransferaset/e2: args2Role-mention-ngram: CONTROLLER histonet(e1: ents2Label-mention-ngram: suppressest.e1: args2Role-mention-ngram: acetyltransferaset7e2: ents2Label-mention-ngram: histone acetyltransferasetje1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp controlled:Positive_regulationt?e1: args2Role-mention-ngram: histone acetyltransferase activitytZe1: trigger-arg-path: suppresses:Negative_regulation >ccomp controlled:Positive_regulationtVe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='melatonin'] controllert_e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp Positive_regulationt$e1: args2Role-mention-ngram: histonet>e2: ents2Label-mention-ngram: SHARED histone acetyltransferasetXe1: trigger-arg-path: suppresses >ccomp [lemma='mediate'] controlled:Positive_regulationtBe1: trigger-arg-path: lemmatizedTrigger=suppress >ccomp controlledt7e1: trigger-arg-path: suppresses >nsubj Simple_chemicaltstrigger-to-trigger-path: e1:suppresses:Negative_regulation >ccomp [lemma='mediate'] e2:mediated:Positive_regulationt'e1: args2Role-mention-ngram: suppressest8e2: ents2Label-mention-ngram: acetyltransferase activityt2e1: trigger-arg-path: suppresses >nsubj controllertMe1: trigger-arg-path: Negative_regulation >ccomp [lemma='mediate'] controlledt;e2: args2Role-mention-ngram: acetyltransferase activity andt7e1: args2Role-mention-ngram: CONTROLLER also suppressest7e1: ents2Label-mention-ngram: histone acetyltransferasetFe1: trigger-arg-path: suppresses >ccomp controlled:Positive_regulationt-e1: ents2Label-mention-ngram: suppresses p300tae1: trigger-arg-path: Negative_regulation >ccomp [lemma='mediate'] controlled:Positive_regulationtFe1: trigger-arg-path: suppresses:Negative_regulation >ccomp controlledthe1: trigger-arg-path: lemmatizedTrigger=suppress >ccomp [lemma='mediate'] controlled:Positive_regulationtVe1: trigger-arg-path: suppresses >nsubj [lemma='melatonin'] controller:Simple_chemicalt2e1: ents2Label-mention-ngram: also suppresses p300t;e1: args2Role-mention-ngram: p300 histone acetyltransferasetKe1: trigger-arg-path: suppresses:Negative_regulation >nsubj Simple_chemicaltVe1: trigger-arg-path: lemmatizedTrigger=suppress >ccomp controlled:Positive_regulationtXe1: trigger-arg-path: suppresses:Negative_regulation >ccomp [lemma='mediate'] controlledtVe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp controlledt,e1: args2Role-mention-ngram: also suppressest)e1: args2Role-mention-ngram: p300 histonetVe1: trigger-arg-path: Negative_regulation >ccomp [lemma='mediate'] Positive_regulationtOe1: trigger-arg-path: suppresses:Negative_regulation >ccomp Positive_regulationtqe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp [lemma='mediate'] Positive_regulationtAe2: args2Role-mention-ngram: CONTROLLER histone acetyltransferaset]e1: trigger-arg-path: lemmatizedTrigger=suppress >ccomp [lemma='mediate'] Positive_regulationtDe1: trigger-arg-path: suppresses >ccomp [lemma='mediate'] controlledt4e1: args2Role-mention-ngram: suppresses p300 histonet?e2: args2Role-mention-ngram: histone acetyltransferase activitytVe1: trigger-arg-path: suppresses:Negative_regulation >nsubj controller:Simple_chemicalthe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp [lemma='mediate'] controlledtnshortest-path: ccomp [lemma='mediate'] >nsubj [lemma='activity'] >nn [lemma='p300']tle1: trigger-arg-path: suppresses:Negative_regulation >ccomp [lemma='mediate'] controlled:Positive_regulationt|e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >ccomp [lemma='mediate'] controlled:Positive_regulationt_e1: trigger-arg-path: suppresses:Negative_regulation >nsubj [lemma='melatonin'] Simple_chemicaltoe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='melatonin'] Simple_chemicalt)e1: args2Role-mention-ngram: activity andtKe1: trigger-arg-path: suppresses >nsubj [lemma='melatonin'] Simple_chemicalt;e1: args2Role-mention-ngram: acetyltransferase activity andtnsubj [lemma='melatonin'] controller:Simple_chemicalt/e1: ents2Label-mention-ngram: acetyltransferaset7e2: args2Role-mention-ngram: acetyltransferase activitytTe1: trigger-arg-path: lemmatizedTrigger=suppress >ccomp [lemma='mediate'] controlledt-interceding-token ngrams: suggesting that Sp1tye2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='rbap46'] Gene_or_gene_productt*interceding-token ngrams: is not regulatedtie2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='hdac1'] themetOe2: trigger-arg-path: Binding nn [lemma='hdac1'] themet interceding-token ngrams: RbAp46t?interceding-tokens-full-span: and HDAC1 , suggesting that Sp1 is not regulated by Ras as well as RbAp46 and may function as a docking protein fortOe2: trigger-arg-path: complex nn [lemma='hdac1'] themet!interceding-token ngrams: dockingtwe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='rbap46'] theme:Gene_or_gene_productt'interceding-token ngrams: not regulatedt#interceding-token ngrams: and HDAC1t%e1: args2Role-mention-ngram: steadilytpe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='sp1'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='rbap46'] themet$interceding-token ngrams: RbAp46 andtxe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='hdac1'] Gene_or_gene_productt&interceding-token ngrams: regulated byt?e1: args2Role-mention-ngram: was steadily co-immunoprecipitatedtee2: trigger-arg-path: Binding nn [lemma='rbap46'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding >prep_with [lemma='rbap46'] themet!interceding-token ngrams: HDAC1 ,tMe1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='rbap46'] themet interceding-token ngrams: by Rast#interceding-token ngrams: a dockingt&e1: ents2Label-mention-ngram: steadilyt)e1: args2Role-mention-ngram: was steadilytbe1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='rbap46'] theme:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='hdac1'] theme:Gene_or_gene_productt%interceding-token ngrams: and HDAC1 ,t_e1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='sp1'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='sp1'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='hdac1'] themet)interceding-token ngrams: may function astge2: trigger-arg-path: complex:Binding nn [lemma='rbap46'] Gene_or_gene_productt_e2: trigger-arg-path: Binding nn [lemma='rbap46'] Gene_or_gene_productt$interceding-token ngrams: Sp1 is nottqe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='rbap46'] Gene_or_gene_productt(interceding-token ngrams: well as RbAp46t)interceding-token ngrams: docking proteint,interceding-token ngrams: HDAC1 , suggestingt;e1: args2Role-mention-ngram: steadily co-immunoprecipitatedt*interceding-token ngrams: regulated by Rastde2: trigger-arg-path: Binding nn [lemma='hdac1'] theme:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='sp1'] theme:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='hdac1'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_with [lemma='rbap46'] theme:Gene_or_gene_productt@e1: args2Role-mention-ngram: steadily co-immunoprecipitated withtnsubjpass [lemma='sp1'] themet^e2: trigger-arg-path: complex nn [lemma='hdac1'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nsubjpass [lemma='sp1'] Gene_or_gene_productt%interceding-token ngrams: that Sp1 ist_e2: trigger-arg-path: complex nn [lemma='rbap46'] Gene_or_gene_productt interceding-token ngrams: Sp1 istqtrigger-to-trigger-path: e1:co-immunoprecipitated:Binding >xcomp >ccomp >prep_as >prep_for >nn e2:complex:Bindingte2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='rbap46'] theme:Gene_or_gene_producttge1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='sp1'] theme:Gene_or_gene_producttae1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='sp1'] Gene_or_gene_producttde1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='rbap46'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: was steadilytee2: trigger-arg-path: complex nn [lemma='rbap46'] theme:Gene_or_gene_producttPe2: trigger-arg-path: complex nn [lemma='rbap46'] themetfe1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='rbap46'] themet&interceding-token ngrams: as a dockingt*interceding-token ngrams: not regulated byt!interceding-token ngrams: and mayt%interceding-token ngrams: Ras as wellt#interceding-token ngrams: by Ras ast?trigger-to-trigger-path: e1:co-immunoprecipitated:Binding >xcomp [lemma='suggest'] >ccomp [lemma='function'] >prep_as [lemma='protein'] >prep_for [lemma='formation'] >nn [lemma='complex'] e2:complex:Bindingtse1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='rbap46'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='sp1'] themet+interceding-token ngrams: a docking proteint~e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='hdac1'] theme:Gene_or_gene_productt'interceding-token ngrams: function as atAe1: ents2Label-mention-ngram: steadily co-immunoprecipitated witht interceding-token ngrams: Ras astPe2: trigger-arg-path: Binding nn [lemma='rbap46'] themetXe2: trigger-arg-path: complex:Binding nn [lemma='rbap46'] themetWe2: trigger-arg-path: complex:Binding nn [lemma='hdac1'] themet[e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='sp1'] themetQe1: trigger-arg-path: Binding >nsubjpass [lemma='sp1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='sp1'] Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT was steadilyt>shortest-path: xcomp >ccomp >prep_as >prep_for >nntle2: trigger-arg-path: complex:Binding nn [lemma='hdac1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: Binding nn [lemma='hdac1'] Gene_or_gene_productt#interceding-token ngrams: as RbAp46t-interceding-token ngrams: docking protein fortNe1: trigger-arg-path: Binding >prep_with [lemma='rbap46'] Gene_or_gene_producttinterceding-token ngrams: Sp1tme2: trigger-arg-path: complex:Binding nn [lemma='rbap46'] theme:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='rbap46'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='rbap46'] Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='rbap46'] Gene_or_gene_productt@e1: ents2Label-mention-ngram: was steadily co-immunoprecipitatedt*interceding-token ngrams: and may functiontde2: trigger-arg-path: complex nn [lemma='hdac1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='sp1'] themet%interceding-token ngrams: function astinterceding-token ngrams: HDAC1tUe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='rbap46'] themetje1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='rbap46'] theme:Gene_or_gene_producttnn [lemma='hdac1'] Gene_or_gene_productt"interceding-token ngrams: that Sp1tje2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='rbap46'] themet interceding-token ngrams: is nott\e1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='rbap46'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='rbap46'] themet6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT wast(interceding-token ngrams: RbAp46 and mayt'interceding-token ngrams: as RbAp46 andt%interceding-token ngrams: protein fort?shortest-path: xcomp [lemma='suggest'] >ccomp [lemma='function'] >prep_as [lemma='protein'] >prep_for [lemma='formation'] >nn [lemma='hdac1']t/e1: args2Role-mention-ngram: THEME was steadilyt#interceding-token ngrams: regulatedtje1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='sp1'] Gene_or_gene_producttRe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='sp1'] themetVe2: trigger-arg-path: Positive_regulation >ccomp [lemma='inhibit'] Positive_regulationtAe2: trigger-arg-path: induced >ccomp [lemma='inhibit'] controlledtIe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp Positive_regulationtoe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='inhibit'] Positive_regulationtDe2: trigger-arg-path: Positive_regulation >ccomp Positive_regulationtHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] controllert]e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_producttCe2: trigger-arg-path: induced >ccomp controlled:Positive_regulationtZe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp Positive_regulationtnsubj [lemma='ft'] controllert3e2: ents2Label-mention-ngram: SHARED induced FAMILYt/e2: trigger-arg-path: induced >ccomp controlledt@e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp controlledtWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] Gene_or_gene_producttCe2: trigger-arg-path: induced:Positive_regulation >ccomp controlledtMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] controllertOe2: trigger-arg-path: Positive_regulation >ccomp controlled:Positive_regulationt,e2: ents2Label-mention-ngram: induced FAMILYt[e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] Positive_regulationtJe2: trigger-arg-path: induced >ccomp [lemma='inhibit'] Positive_regulationtRe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='inhibit'] controlledtve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_producttMe2: trigger-arg-path: Positive_regulation >ccomp [lemma='inhibit'] controlledt8e2: trigger-arg-path: induced >ccomp Positive_regulationtUe2: trigger-arg-path: induced >ccomp [lemma='inhibit'] controlled:Positive_regulationthe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp controlled:Positive_regulationtee2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] controllertze2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='inhibit'] controlled:Positive_regulationtUe2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='inhibit'] controlledtQe2: trigger-arg-path: induced >nsubj [lemma='ft'] controller:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] controlled:Positive_regulationtLe2: trigger-arg-path: induced:Positive_regulation >ccomp Positive_regulationt7e2: ents2Label-mention-ngram: induced FAMILY inhibitiontke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ft'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp controlled:Positive_regulationtae2: trigger-arg-path: Positive_regulation >ccomp [lemma='inhibit'] controlled:Positive_regulationtFe2: trigger-arg-path: induced >nsubj [lemma='ft'] Gene_or_gene_productt^e2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='inhibit'] Positive_regulationtie2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='inhibit'] controlled:Positive_regulationtRe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='inhibit'] controlledtWe2: trigger-arg-path: induced:Positive_regulation >ccomp controlled:Positive_regulationtPe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ft'] controllert0e1: ents2Label-mention-ngram: SHARED induced RastTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp controlledtbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ft'] controller:Gene_or_gene_productt^e1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation vmod [lemma='promote'] e2:promoted:Positive_regulationtce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent >nn Gene_or_gene_producttZe1: trigger-arg-path: associates:Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] themetHe2: trigger-arg-path: promoted prep_with [lemma='pten'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_regulation prep_with [lemma='pten'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='pten'] themet4e1: args2Role-mention-ngram: protein associates withtoe1: trigger-arg-path: associates:Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLED promotedtpe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_with [lemma='pten'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='pten'] themet{e2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='variant'] >nn [lemma='mc1r'] controller:Gene_or_gene_productt=e2: trigger-arg-path: Positive_regulation agent >nn controller:Gene_or_gene_producttHe2: trigger-arg-path: Positive_regulation agent >nn Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=promote nsubj >nn theme:Gene_or_gene_producttje2: trigger-arg-path: promoted >agent [lemma='variant'] >nn [lemma='mc1r'] controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='pten'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED protein associatestze1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=promote prep_with [lemma='pten'] themetOe1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] themet@e1: trigger-arg-path: associates >prep_with [lemma='pten'] themet~e2: trigger-arg-path: promoted:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] controller:Gene_or_gene_producttue2: trigger-arg-path: Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] controller:Gene_or_gene_productt]e1: trigger-arg-path: associates:Binding >prep_with [lemma='pten'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='pten'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='protein'] >nn [lemma='mc1r'] theme:Gene_or_gene_producttBe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj >nn themet,e1: ents2Label-mention-ngram: SHARED proteint/e2: trigger-arg-path: promoted agent [lemma='variant'] >nn [lemma='mc1r'] Gene_or_gene_producttBe1: ents2Label-mention-ngram: associates with GENE_OR_GENE_PRODUCTtQe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj >nn Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='variant'] >nn [lemma='mc1r'] controllertVe2: trigger-arg-path: Positive_regulation agent >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] theme:Gene_or_gene_producttge1: trigger-arg-path: associates >nsubj [lemma='protein'] >nn [lemma='mc1r'] theme:Gene_or_gene_producttUe2: trigger-arg-path: promoted >agent [lemma='variant'] >nn [lemma='mc1r'] controllert2e2: trigger-arg-path: promoted nsubj >nn themet2e1: args2Role-mention-ngram: associates with THEMEtQe2: trigger-arg-path: promoted:Positive_regulation nsubj >nn theme:Gene_or_gene_producttFe2: trigger-arg-path: promoted:Positive_regulation vmodtYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent >nn controllertie2: trigger-arg-path: promoted:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] controllertje2: trigger-arg-path: promoted:Positive_regulation nsubj [lemma='protein'] >nn [lemma='mc1r'] themet?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] Gene_or_gene_producttKe2: trigger-arg-path: promoted nsubj [lemma='protein'] >nn [lemma='mc1r'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj >nn theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation agent [lemma='variant'] >nn [lemma='mc1r'] Gene_or_gene_productt=e2: trigger-arg-path: promoted prep_with [lemma='pten'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj >nn Gene_or_gene_productt\e2: trigger-arg-path: promoted:Positive_regulation prep_with [lemma='pten'] Gene_or_gene_producttUe1: trigger-arg-path: associates >prep_with [lemma='pten'] theme:Gene_or_gene_producttse2: trigger-arg-path: promoted:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] Gene_or_gene_producttde1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='mc1r'] theme:Gene_or_gene_producttCe2: trigger-arg-path: promoted:Positive_regulation nsubj >nn Gene_or_gene_productt5e1: ents2Label-mention-ngram: protein associates withtQe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='pten'] themet@e2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='protein'] >nn [lemma='mc1r'] themetae2: trigger-arg-path: Positive_regulation agent [lemma='variant'] >nn [lemma='mc1r'] controllertHe1: trigger-arg-path: associates:Binding >nsubj >nn Gene_or_gene_productt8e2: ents2Label-mention-ngram: transformation promoted bytpe2: trigger-arg-path: lemmatizedTrigger=promote >agent [lemma='variant'] >nn [lemma='mc1r'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='protein'] >nn [lemma='mc1r'] themet5e1: args2Role-mention-ngram: THEME protein associatestVe2: trigger-arg-path: promoted nsubj [lemma='protein'] >nn [lemma='mc1r'] Gene_or_gene_producttOe1: trigger-arg-path: associates >prep_with [lemma='pten'] Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLED promoted bytne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent >nn controller:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj >nn themetWe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] controller:Gene_or_gene_productt9e1: trigger-arg-path: associates:Binding >nsubj >nn themetre1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='protein'] >nn [lemma='mc1r'] Gene_or_gene_productt^trigger-to-trigger-path: e1:transformation:Generic_event >vmod e2:promoted:Positive_regulationtze2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >agent [lemma='variant'] >nn [lemma='mc1r'] controllert/e1: args2Role-mention-ngram: protein associatest(e1: args2Role-mention-ngram: a trimetrict(e1: ents2Label-mention-ngram: promotes atWshortest-path: dobj [lemma='formation'] >nn [lemma='complex']tge2: trigger-arg-path: Binding prep_between [lemma='eps8'] Gene_or_gene_producttge2: trigger-arg-path: Binding prep_between [lemma='e3b1'] Gene_or_gene_productt,e2: args2Role-mention-ngram: between THEME ,t?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='e3b1'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: formation between EpS8tDe2: ents2Label-mention-ngram: formation between GENE_OR_GENE_PRODUCTtme2: trigger-arg-path: Binding prep_between [lemma='eps8'] theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='eps8'] themetbe2: trigger-arg-path: complex formation prep_between [lemma='eps8'] themet\e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='p66shc'] Gene_or_gene_producttKe1: trigger-arg-path: promotes >nsubj [lemma='p66shc'] Gene_or_gene_productt'e1: args2Role-mention-ngram: promotes at$e1: ents2Label-mention-ngram: EpS8 ,t'e1: ents2Label-mention-ngram: trimetrictVe1: trigger-arg-path: promotes >nsubj [lemma='p66shc'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: EpS8 , SHAREDtLe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p66shc'] controllert1e1: ents2Label-mention-ngram: a trimetric complext,e1: ents2Label-mention-ngram: between EpS8 ,t$e2: args2Role-mention-ngram: , THEMEtbe2: trigger-arg-path: complex formation prep_between [lemma='e3b1'] themet|e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='e3b1'] themetotrigger-to-trigger-path: e1:promotes:Positive_regulation >dobj [lemma='formation'] e2:complex formation:Bindingtqe2: trigger-arg-path: complex formation prep_between [lemma='eps8'] Gene_or_gene_producttye2: trigger-arg-path: complex formation:Binding prep_between [lemma='eps8'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='p66shc'] controllertje1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='p66shc'] controller:Gene_or_gene_productt[trigger-to-trigger-path: e1:promotes:Positive_regulation >dobj e2:complex formation:Bindingte2: trigger-arg-path: complex formation:Binding prep_between [lemma='eps8'] theme:Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT promotes atye2: trigger-arg-path: complex formation:Binding prep_between [lemma='e3b1'] Gene_or_gene_producttqe2: trigger-arg-path: complex formation prep_between [lemma='e3b1'] Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER promotes at;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='eps8'] theme:Gene_or_gene_producttUe1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='p66shc'] controllertwe2: trigger-arg-path: complex formation prep_between [lemma='eps8'] theme:Gene_or_gene_producttprep_between [lemma='eps8'] theme:Gene_or_gene_producttje2: trigger-arg-path: complex formation:Binding prep_between [lemma='eps8'] themetXe2: trigger-arg-path: Binding prep_between [lemma='eps8'] themet2e1: ents2Label-mention-ngram: promotes a trimetrict*e1: ents2Label-mention-ngram: between EpS8tAe1: trigger-arg-path: promotes >nsubj [lemma='p66shc'] controllertVe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p66shc'] Gene_or_gene_producttme2: trigger-arg-path: Binding prep_between [lemma='e3b1'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='eps8'] themet"e1: ents2Label-mention-ngram: EpS8tge1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='p66shc'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='eps8'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation:Binding prep_between [lemma='e3b1'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='p66shc'] Gene_or_gene_producttje2: trigger-arg-path: complex formation:Binding prep_between [lemma='e3b1'] themet)e1: ents2Label-mention-ngram: a trimetrict*e1: ents2Label-mention-ngram: , SHARED andt1e1: args2Role-mention-ngram: trimetric CONTROLLEDtXe2: trigger-arg-path: Binding prep_between [lemma='e3b1'] themette2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='e3b1'] themetwe2: trigger-arg-path: complex formation prep_between [lemma='e3b1'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: trimetric complext1e1: args2Role-mention-ngram: promotes a trimetrict?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='eps8'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='p66shc'] controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: trimetric complex formationt&e1: args2Role-mention-ngram: trimetrictRe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='p66shc'] controllert3e1: args2Role-mention-ngram: a trimetric CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='e3b1'] Gene_or_gene_productt_e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='p66shc'] Gene_or_gene_productte2: trigger-arg-path: complex formation:Binding prep_between [lemma='e3b1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex formation prep_between [lemma='e3b1'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME , THEMEtae1: trigger-arg-path: Positive_regulation >nsubj [lemma='p66shc'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: and ERK inhibitiont!e2: ents2Label-mention-ngram: didt'e1: args2Role-mention-ngram: did inducet%e2: ents2Label-mention-ngram: the DNAt8e1: trigger-arg-path: induce >nsubj Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] Gene_or_gene_producttse2: trigger-arg-path: induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: did inducete2: trigger: inducetQe1: trigger-arg-path: induce >nsubj [lemma='akt'] controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: induce phosphorylation oft%e1: ents2Label-mention-ngram: the DNAt2e2: args2Role-mention-ngram: did induce CONTROLLEDtle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productt.e2: args2Role-mention-ngram: induce CONTROLLEDt_e2: trigger-arg-path: induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] Gene_or_gene_productt2e2: trigger-arg-path: induce >nsubj >nn controllert2e1: args2Role-mention-ngram: inhibition did inducet~e2: trigger-arg-path: induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controller:Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibition didt(e2: ents2Label-mention-ngram: DNA SHAREDt3e2: ents2Label-mention-ngram: inhibition did inducet0e1: ents2Label-mention-ngram: and ERK inhibitiont3e1: ents2Label-mention-ngram: inhibition did inducetge2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] controllert,e1: ents2Label-mention-ngram: ERK inhibitiontwe2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: ERK inhibition didt6e2: args2Role-mention-ngram: CONTROLLER inhibition didt.e1: trigger-arg-path: induce >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] Gene_or_gene_producttbe2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controllert[e2: trigger-arg-path: induce:Negative_regulation >nsubj >nn controller:Gene_or_gene_producttLe1: trigger-arg-path: induce:Positive_regulation >nsubj Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >nn controllertGe2: trigger-arg-path: induce >nsubj >nn controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='akt'] controllert|e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] controller:Gene_or_gene_producttTe2: trigger-arg-path: Negative_regulation >nsubj >nn controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: the DNA SHAREDt e2: args2Role-mention-ngram: didtnsubj [lemma='akt'] controllert(e2: ents2Label-mention-ngram: of the DNAt$e1: args2Role-mention-ngram: and ERKtbe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj >nn Gene_or_gene_productt.e1: args2Role-mention-ngram: induce CONTROLLEDt8e1: ents2Label-mention-ngram: did induce phosphorylationt0e1: ents2Label-mention-ngram: ERK inhibition didtFe1: trigger-arg-path: induce >nsubj [lemma='akt'] Gene_or_gene_producttnsubj >nn Gene_or_gene_productt2e1: args2Role-mention-ngram: did induce CONTROLLEDt{e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controllert,e2: ents2Label-mention-ngram: the DNA SHAREDt8shortest-path: aux [lemma='do']t?e2: trigger-arg-path: Negative_regulation >nsubj >nn controllertPe1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='akt'] controllert4e2: ents2Label-mention-ngram: induce phosphorylationt,e1: ents2Label-mention-ngram: inhibition didt e1: args2Role-mention-ngram: ERKtWe1: trigger-arg-path: induce:Positive_regulation >nsubj controller:Gene_or_gene_producttZe1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='akt'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: and ERKt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and ERKtFe2: trigger-arg-path: induce:Negative_regulation >nsubj >nn controllertCe1: trigger-arg-path: induce >nsubj controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: did inducet+e2: args2Role-mention-ngram: inhibition didt+e1: args2Role-mention-ngram: ERK inhibitiont,e2: ents2Label-mention-ngram: inhibition didtXe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='akt'] Gene_or_gene_productt'e2: args2Role-mention-ngram: did inducet?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controller:Gene_or_gene_producttje2: trigger-arg-path: induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] controller:Gene_or_gene_producttUe2: trigger-arg-path: induce >nsubj [lemma='inhibition'] >nn [lemma='erk'] controllertBe1: trigger-arg-path: induce:Positive_regulation >nsubj controllertce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='akt'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: inhibition did inducetee1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='akt'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Negative_regulation >nsubj >nn Gene_or_gene_productt(e1: ents2Label-mention-ngram: of the DNAtie2: trigger-arg-path: induce:Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] controllert8e2: ents2Label-mention-ngram: did induce phosphorylationtwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='akt'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER and ERKtPe2: trigger-arg-path: induce:Negative_regulation >nsubj >nn Gene_or_gene_producttle2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >nn [lemma='erk'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='akt'] controllert4e1: ents2Label-mention-ngram: induce phosphorylationt7e2: ents2Label-mention-ngram: induce phosphorylation oft+e1: args2Role-mention-ngram: inhibition didt!e1: ents2Label-mention-ngram: ERKtOe2: trigger-arg-path: Positive_activation >nsubj >nn controller:Simple_chemicalte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt3e2: ents2Label-mention-ngram: interleukin-1 inducedt6e1: trigger-arg-path: complex >nn [lemma='tak1'] themetge2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] controlledtdobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: complex:Binding >nn [lemma='traf6'] themet]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn Simple_chemicaltotrigger-to-trigger-path: e1:complex:Binding nn [lemma='traf6'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: formation of thetwe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt?e2: trigger-arg-path: Positive_activation >nsubj >nn controllertze2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicaltVe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='tak1'] controlledtfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] theme:Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllertXe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controllert[e2: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicaltPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] themet-e2: args2Role-mention-ngram: and TAK1 complextje2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledt*e2: ents2Label-mention-ngram: TAK1 complexthe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controller:Simple_chemicaltoe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicalt*e2: ents2Label-mention-ngram: of the TRAF6t*e2: args2Role-mention-ngram: interleukin-1tKe1: trigger-arg-path: complex >nn [lemma='tak1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicaltte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt4shortest-path: nntle2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt.e2: args2Role-mention-ngram: TAK1 complex thatt'e2: ents2Label-mention-ngram: the TRAF6t%e2: args2Role-mention-ngram: and TAK1tKe1: trigger-arg-path: Binding >nn [lemma='tak1'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] controllert`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] Gene_or_gene_productt*e2: args2Role-mention-ngram: that mediatest1e2: ents2Label-mention-ngram: by interfering witht"e2: ents2Label-mention-ngram: TAK1t3e2: args2Role-mention-ngram: mediates interleukin-1t7e1: trigger-arg-path: Binding >nn [lemma='traf6'] themet.e2: ents2Label-mention-ngram: interfering withtQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] themetFe1: trigger-arg-path: complex >nn [lemma='traf6'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: TRAF6 andt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicalt_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] Gene_or_gene_productt7e1: trigger-arg-path: complex >nn [lemma='traf6'] themet+e2: ents2Label-mention-ngram: interleukin-1t2e2: args2Role-mention-ngram: complex that mediatest)e2: args2Role-mention-ngram: TAK1 complext8e2: trigger-arg-path: induced >nsubj >nn Simple_chemicalt6e2: args2Role-mention-ngram: activation by interferingt^e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] theme:Gene_or_gene_producttWe2: trigger-arg-path: induced:Positive_activation >nsubj >nn controller:Simple_chemicalt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllertwe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt1e2: args2Role-mention-ngram: interfering with thet:e2: ents2Label-mention-ngram: interleukin-1 induced SHAREDt&e2: args2Role-mention-ngram: the TRAF6t0e2: ents2Label-mention-ngram: with the formationt*e2: ents2Label-mention-ngram: complex thattCe2: trigger-arg-path: induced >nsubj >nn controller:Simple_chemicaltLe2: trigger-arg-path: induced:Positive_activation >nsubj >nn Simple_chemicalt/e2: ents2Label-mention-ngram: TAK1 complex thatt`e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_producttEe1: trigger-arg-path: complex >nn [lemma='tak1'] Gene_or_gene_productt;e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL activation byt&e2: ents2Label-mention-ngram: and TAK1t/e2: args2Role-mention-ngram: with the formationt;e2: args2Role-mention-ngram: mediates interleukin-1 inducedt-e2: args2Role-mention-ngram: interfering witht&e2: args2Role-mention-ngram: TRAF6 andtWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >nn [lemma='traf6'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: interfering with thetge2: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicalt+e2: ents2Label-mention-ngram: that mediatest9e2: ents2Label-mention-ngram: that mediates interleukin-1t+e2: args2Role-mention-ngram: by interferingt>e1: trigger-arg-path: complex:Binding >nn [lemma='tak1'] themetIe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] themet2e2: args2Role-mention-ngram: interleukin-1 inducedtSe1: trigger-arg-path: complex:Binding >nn [lemma='tak1'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: by interferingtXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledtee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] controllertFe1: trigger-arg-path: Binding >nn [lemma='traf6'] Gene_or_gene_productt)e2: args2Role-mention-ngram: of the TRAF6t"e2: args2Role-mention-ngram: TRAF6t.e2: ents2Label-mention-ngram: formation of thetDe2: trigger-arg-path: Positive_activation >nsubj >nn Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicalt0e2: args2Role-mention-ngram: by interfering witht#e2: ents2Label-mention-ngram: TRAF6tje2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllert+e2: args2Role-mention-ngram: TRAF6 and TAK1t)e2: ents2Label-mention-ngram: interferingt6e1: trigger-arg-path: Binding >nn [lemma='tak1'] themet,e2: ents2Label-mention-ngram: TRAF6 and TAK1t]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] theme:Gene_or_gene_producttTe1: trigger-arg-path: complex:Binding >nn [lemma='traf6'] theme:Gene_or_gene_productt7e2: ents2Label-mention-ngram: activation by interferingt|e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt)e2: args2Role-mention-ngram: complex thatt*e2: args2Role-mention-ngram: the TRAF6 andtMe1: trigger-arg-path: complex:Binding >nn [lemma='tak1'] Gene_or_gene_producttre2: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt.e2: ents2Label-mention-ngram: and TAK1 complextTe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controller:Simple_chemicaltEe1: trigger-arg-path: Binding >nn [lemma='tak1'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: complex that mediatest?shortest-path: nn [lemma='nfb']t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: mediates interleukin-1t5e2: args2Role-mention-ngram: CONTROLLER activation byt8e2: args2Role-mention-ngram: that mediates interleukin-1t+e2: ents2Label-mention-ngram: the TRAF6 andt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledt8e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL activationt=e2: args2Role-mention-ngram: interleukin-1 induced CONTROLLEDtGe2: trigger-arg-path: induced:Positive_activation >nsubj >nn controllert?trigger-to-trigger-path: e1:complex:Binding nn [lemma='traf6'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] themetIe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn Simple_chemicalt(e2: args2Role-mention-ngram: interferingt!interceding-token ngrams: neuritet/e2: ents2Label-mention-ngram: rapid , sustainedt(e2: args2Role-mention-ngram: , sustainedt1e1: args2Role-mention-ngram: transient CONTROLLEDt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducest5e1: args2Role-mention-ngram: CONTROLLER induces rapidt'interceding-token ngrams: in contrast ,tMe2: trigger-arg-path: induces >dobj [lemma='phosphorylation'] PhosphorylationtXe2: trigger-arg-path: induces:Positive_regulation >nsubj controller:Gene_or_gene_productt-interceding-token ngrams: rather than neuritetje1: trigger-arg-path: induces >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: , transientt-e1: ents2Label-mention-ngram: induces rapid ,t.interceding-token ngrams: proliferation rathert*e1: args2Role-mention-ngram: induces rapidt%e2: ents2Label-mention-ngram: rapid ,tBe2: trigger-arg-path: induces:Positive_regulation >dobj controlledtwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_productt^e1: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] controllert0interceding-token ngrams: than neurite outgrowtht'interceding-token ngrams: proliferationt3e2: args2Role-mention-ngram: , sustained CONTROLLEDt%interceding-token ngrams: outgrowth ;t0e2: ents2Label-mention-ngram: , sustained SHAREDtHe2: trigger-arg-path: induces >dobj [lemma='phosphorylation'] controlledt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces rapidt5e2: args2Role-mention-ngram: CONTROLLER induces rapidt-interceding-token ngrams: neurite outgrowth ;t&interceding-token ngrams: than neuritet*e2: args2Role-mention-ngram: induces rapidtie1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt%e1: ents2Label-mention-ngram: rapid ,t1interceding-token ngrams: eliciting proliferationt3interceding-token ngrams: , eliciting proliferationt$e1: args2Role-mention-ngram: rapid ,tMe2: trigger-arg-path: induces:Positive_regulation >nsubj Gene_or_gene_producttQe2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ngf'] controllert%interceding-token ngrams: rather thant?shortest-path: dobj [lemma='activation'] >dep [lemma='elicit'] >parataxis [lemma='induce'] >nsubj [lemma='ngf']t$interceding-token ngrams: contrast ,t=e2: trigger-arg-path: induces >nsubj [lemma='ngf'] controllert[e1: trigger-arg-path: induces:Positive_activation >dobj >nn controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: transient SHAREDt>e2: ents2Label-mention-ngram: sustained SHARED phosphorylationt/e1: ents2Label-mention-ngram: rapid , transientt{e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt"interceding-token ngrams: contrastt[e2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ngf'] Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn controlledt_e1: trigger-arg-path: induces >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttfe2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ngf'] controller:Gene_or_gene_productt+interceding-token ngrams: neurite outgrowthtRe1: trigger-arg-path: induces >nsubj [lemma='egf'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER inducestNe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] controllertGe2: trigger-arg-path: induces:Positive_regulation >dobj Phosphorylationt%interceding-token ngrams: in contrastt+e2: ents2Label-mention-ngram: induces rapidt#interceding-token ngrams: outgrowthtpinterceding-tokens-full-span: activation , eliciting proliferation rather than neurite outgrowth ; in contrast ,t?trigger-to-trigger-path: e1:induces:Positive_activation >dobj [lemma='activation'] >dep [lemma='elicit'] >parataxis [lemma='induce'] e2:induces:Positive_regulationtze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledtle2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt1e2: args2Role-mention-ngram: sustained CONTROLLEDtke1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt interceding-token ngrams: rathertGe2: trigger-arg-path: induces >nsubj [lemma='ngf'] Gene_or_gene_producttQe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='egf'] controllert3interceding-token ngrams: proliferation rather thant.e2: trigger-arg-path: induces >dobj controlledtCe2: trigger-arg-path: induces:Positive_regulation >nsubj controllertFe1: trigger-arg-path: induces:Positive_activation >dobj >nn controlledt3e2: trigger-arg-path: induces >dobj Phosphorylationt~e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttGe1: trigger-arg-path: induces >nsubj [lemma='egf'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: , transient SHAREDt.e2: ents2Label-mention-ngram: sustained SHAREDt$e2: args2Role-mention-ngram: rapid ,tve1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt(interceding-token ngrams: outgrowth ; intXe2: trigger-arg-path: induces >dobj [lemma='phosphorylation'] controlled:Phosphorylationtae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt8interceding-token ngrams: eliciting proliferation rathert&e1: args2Role-mention-ngram: transienttXe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='egf'] Gene_or_gene_producttfe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_producttRe2: trigger-arg-path: induces >nsubj [lemma='ngf'] controller:Gene_or_gene_producttae2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtMe1: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn Gene_or_gene_producttae1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt'interceding-token ngrams: ; in contrastt#e1: ents2Label-mention-ngram: rapidt+e1: ents2Label-mention-ngram: induces rapidtGe1: trigger-arg-path: induces >dobj >nn controlled:Gene_or_gene_producttUe1: trigger-arg-path: induces >dobj [lemma='activation'] >nn [lemma='erk'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt"e1: args2Role-mention-ngram: rapidtse1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttDe2: trigger-arg-path: induces >nsubj controller:Gene_or_gene_productt%interceding-token ngrams: , elicitingt)e2: ents2Label-mention-ngram: , sustainedtXe1: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: sustainedt&e2: args2Role-mention-ngram: sustainedt\e2: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] controlledtltrigger-to-trigger-path: e1:induces:Positive_activation >dobj >dep >parataxis e2:induces:Positive_regulationt=e1: trigger-arg-path: induces >nsubj [lemma='egf'] controllertinterceding-token ngrams: ; int,e1: args2Role-mention-ngram: induces rapid ,t/e2: trigger-arg-path: induces >nsubj controllert)e1: ents2Label-mention-ngram: , transientt>e2: trigger-arg-path: induces >dobj controlled:Phosphorylationt2e1: trigger-arg-path: induces >dobj >nn controlledt-e2: ents2Label-mention-ngram: induces rapid ,t.e2: args2Role-mention-ngram: rapid , sustainedtWe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn controlledt3e1: args2Role-mention-ngram: , transient CONTROLLEDtdobj >nn Gene_or_gene_producttRe2: trigger-arg-path: induces:Positive_regulation >dobj controlled:Phosphorylationt"e2: args2Role-mention-ngram: rapidt9e2: trigger-arg-path: induces >nsubj Gene_or_gene_producttPe1: trigger-arg-path: induces:Positive_activation >dobj >nn Gene_or_gene_productt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces rapidt2shortest-path: dobj >dep >parataxis >nsubjt.e1: args2Role-mention-ngram: rapid , transienttSe1: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: transientt#e2: ents2Label-mention-ngram: rapidt#interceding-token ngrams: elicitingt[e1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='egf'] Gene_or_gene_productt,e2: args2Role-mention-ngram: induces rapid ,t0interceding-token ngrams: activation , elicitingtfe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] controlledtIe1: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] controllert-e2: ents2Label-mention-ngram: irreversibly tot,e1: args2Role-mention-ngram: irreversibly tot[e2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='egfr'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: binds irreversiblyt4e1: ents2Label-mention-ngram: irreversibly to SHAREDt#e1: ents2Label-mention-ngram: TovoktPe1: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED and HER2t"e1: args2Role-mention-ngram: Tovokt%e1: ents2Label-mention-ngram: Tovok )t)e2: ents2Label-mention-ngram: type SHAREDtTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='bibw2992'] themet)e2: args2Role-mention-ngram: HER2 and cant'e1: ents2Label-mention-ngram: ( Tovok )t1e2: args2Role-mention-ngram: wild type CONTROLLEDt;e1: trigger-arg-path: binds >nsubj [lemma='bibw2992'] themet-e2: ents2Label-mention-ngram: and can inhibitt2e1: ents2Label-mention-ngram: ) binds irreversiblyt+e1: ents2Label-mention-ngram: Tovok ) bindst,e1: ents2Label-mention-ngram: SHARED ( Tovokt)e2: args2Role-mention-ngram: and HER2 andt*e1: ents2Label-mention-ngram: irreversiblytce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='bibw2992'] Gene_or_gene_producttQe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='egfr'] controlledtPe1: trigger-arg-path: binds >nsubj [lemma='bibw2992'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: irreversiblytdtrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='inhibit'] e2:inhibit:Negative_activationt9e1: trigger-arg-path: binds >prep_to [lemma='egfr'] themet"e2: ents2Label-mention-ngram: typet.e2: args2Role-mention-ngram: inhibit both wildt=e1: trigger-arg-path: Binding >nsubj [lemma='bibw2992'] themetVe1: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: ) bindstce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='egfr'] controlledt-e2: args2Role-mention-ngram: can inhibit bothtLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='bibw2992'] themet$e2: args2Role-mention-ngram: and cant%e2: args2Role-mention-ngram: and HER2t,e2: args2Role-mention-ngram: and can inhibittxe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='egfr'] controlled:Gene_or_gene_productt#e2: ents2Label-mention-ngram: Tovokt"e2: ents2Label-mention-ngram: HER2t$e1: args2Role-mention-ngram: ) bindst/e2: ents2Label-mention-ngram: inhibit both wildt*e1: args2Role-mention-ngram: THEME ( TovoktRe2: trigger-arg-path: inhibit >dobj [lemma='egfr'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='egfr'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: ) bindst&e2: ents2Label-mention-ngram: and HER2tae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: wild typet&e2: args2Role-mention-ngram: wild typet0e2: ents2Label-mention-ngram: binds irreversiblyt=e2: trigger-arg-path: inhibit >dobj [lemma='egfr'] controlledt,e2: ents2Label-mention-ngram: SHARED ( Tovokt4e2: ents2Label-mention-ngram: irreversibly to SHAREDt1e1: args2Role-mention-ngram: ) binds irreversiblyt!e2: args2Role-mention-ngram: wildtJe1: trigger-arg-path: Binding >prep_to [lemma='egfr'] Gene_or_gene_producttGe2: trigger-arg-path: inhibit >dobj [lemma='egfr'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: irreversibly totOe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='egfr'] controlledtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] themet2e1: args2Role-mention-ngram: irreversibly to THEMEt.e2: ents2Label-mention-ngram: wild type SHAREDt*e1: args2Role-mention-ngram: Tovok ) bindstHe1: trigger-arg-path: binds >prep_to [lemma='egfr'] Gene_or_gene_producttRtrigger-to-trigger-path: e1:binds:Binding >conj_and e2:inhibit:Negative_activationtNe1: trigger-arg-path: binds >prep_to [lemma='egfr'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: binds irreversibly totae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='bibw2992'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: inhibit botht'e2: ents2Label-mention-ngram: ( Tovok )t%e2: args2Role-mention-ngram: HER2 andtXe1: trigger-arg-path: binds:Binding >nsubj [lemma='bibw2992'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: HER2 and cant^e2: trigger-arg-path: Negative_activation >dobj [lemma='egfr'] controlled:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='egfr'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Negative_activation >dobj [lemma='egfr'] controlledt)e2: ents2Label-mention-ngram: can inhibitt&e2: args2Role-mention-ngram: both wildtPe1: trigger-arg-path: Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER and HER2t'e2: ents2Label-mention-ngram: both wildt,e2: args2Role-mention-ngram: type CONTROLLEDt*e2: ents2Label-mention-ngram: and HER2 andt[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='bibw2992'] Gene_or_gene_productt2e1: args2Role-mention-ngram: binds irreversibly totRe1: trigger-arg-path: binds:Binding >nsubj [lemma='bibw2992'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >nsubj [lemma='bibw2992'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='egfr'] Gene_or_gene_productt$e1: args2Role-mention-ngram: ( Tovoktme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='egfr'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: binds irreversibly tot%e2: ents2Label-mention-ngram: Tovok )t,e2: ents2Label-mention-ngram: both wild typet&e1: args2Role-mention-ngram: ( Tovok )t+e2: args2Role-mention-ngram: both wild typet%e2: ents2Label-mention-ngram: ( TovoktAe1: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] themetYe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='egfr'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='egfr'] themet/e1: args2Role-mention-ngram: binds irreversiblyt+e2: ents2Label-mention-ngram: Tovok ) bindst2e2: ents2Label-mention-ngram: ) binds irreversiblyt&e2: ents2Label-mention-ngram: HER2 andt(e2: args2Role-mention-ngram: can inhibitt)e1: args2Role-mention-ngram: irreversiblyt$e1: args2Role-mention-ngram: Tovok )tLe1: trigger-arg-path: Binding >nsubj [lemma='bibw2992'] Gene_or_gene_productt)e2: args2Role-mention-ngram: inhibit botht!e2: args2Role-mention-ngram: HER2tSe2: trigger-arg-path: Negative_activation >dobj [lemma='egfr'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: can inhibit botht%e2: ents2Label-mention-ngram: and cant%e1: ents2Label-mention-ngram: ( TovoktJe1: trigger-arg-path: binds >nsubj [lemma='bibw2992'] Gene_or_gene_producttCe1: trigger-arg-path: binds:Binding >nsubj [lemma='bibw2992'] themet"e2: ents2Label-mention-ngram: wildt!e2: args2Role-mention-ngram: typetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='bibw2992'] theme:Gene_or_gene_producttfe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='egfr'] controlled:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='egfr'] controlled:Gene_or_gene_producttstrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='ubiquitinate'] e2:ubiquitinated:Positive_regulationtagent [lemma='nedd4'] controllert!e2: ents2Label-mention-ngram: UBDtUe1: trigger-arg-path: interacts >prep_with [lemma='nedd4'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate agent [lemma='nedd4'] controller:Gene_or_gene_producttKe2: trigger-arg-path: Positive_regulation >agent [lemma='nedd4'] controllertXe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate nsubj [lemma='eps15'] theme:Gene_or_gene_producttne2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='nedd4'] controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='eps15'] themet(e2: ents2Label-mention-ngram: UBD and istBe2: trigger-arg-path: Positive_regulation prep_with [lemma='nedd4'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation nsubj [lemma='eps15'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='nedd4'] controllert#e2: ents2Label-mention-ngram: NEDD4tte2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation >agent [lemma='nedd4'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: UBD andt)e2: ents2Label-mention-ngram: via its UBDtHe1: trigger-arg-path: interacts:Binding >prep_with [lemma='nedd4'] themethe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nedd4'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nedd4'] themette2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation conj_and e2:ubiquitinated:Positive_regulationtde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='eps15'] Gene_or_gene_producttSe1: trigger-arg-path: interacts:Binding >nsubj [lemma='eps15'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=ubiquitinate prep_with [lemma='nedd4'] theme:Gene_or_gene_producttYe1: trigger-arg-path: interacts:Binding >nsubj [lemma='eps15'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='eps15'] theme:Gene_or_gene_producttWe1: trigger-arg-path: interacts:Binding >prep_with [lemma='nedd4'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: via itst5e2: ents2Label-mention-ngram: ubiquitinated by SHAREDtQe1: trigger-arg-path: interacts >nsubj [lemma='eps15'] theme:Gene_or_gene_producttDe1: trigger-arg-path: interacts:Binding >nsubj [lemma='eps15'] themetMe2: trigger-arg-path: Positive_regulation prep_with [lemma='nedd4'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: with NEDD4 viatZe2: trigger-arg-path: ubiquitinated >agent [lemma='nedd4'] controller:Gene_or_gene_producttLe2: trigger-arg-path: ubiquitinated:Positive_regulation agent [lemma='nedd4'] controllertMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='eps15'] themetje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='eps15'] theme:Gene_or_gene_producttKe2: trigger-arg-path: ubiquitinated prep_with [lemma='nedd4'] theme:Gene_or_gene_productt8e2: trigger-arg-path: ubiquitinated nsubj [lemma='eps15'] Gene_or_gene_producttOe2: trigger-arg-path: ubiquitinated >agent [lemma='nedd4'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=ubiquitinate agent [lemma='nedd4'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nedd4'] themet>e1: trigger-arg-path: Binding >prep_with [lemma='nedd4'] themetUe2: trigger-arg-path: Positive_regulation nsubj [lemma='eps15'] themet`e2: trigger-arg-path: Positive_regulation >agent [lemma='nedd4'] controller:Gene_or_gene_producttPe2: trigger-arg-path: ubiquitinated:Positive_regulation prep_with [lemma='nedd4'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED interacts directlytke2: trigger-arg-path: lemmatizedTrigger=ubiquitinate >agent [lemma='nedd4'] controller:Gene_or_gene_productt[e2: trigger-arg-path: ubiquitinated:Positive_regulation agent [lemma='nedd4'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: with NEDD4t:e1: trigger-arg-path: Binding >nsubj [lemma='eps15'] themet%e2: ents2Label-mention-ngram: its UBDtQe2: trigger-arg-path: Positive_regulation prep_with [lemma='nedd4'] theme:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=ubiquitinate:Positive_regulation agent [lemma='nedd4'] controllertce2: trigger-arg-path: ubiquitinated:Positive_regulation prep_with [lemma='nedd4'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: interacts directly withtKe1: trigger-arg-path: interacts >nsubj [lemma='eps15'] Gene_or_gene_producttce2: trigger-arg-path: ubiquitinated:Positive_regulation >agent [lemma='nedd4'] Gene_or_gene_productt@e1: trigger-arg-path: interacts >prep_with [lemma='nedd4'] themet0e2: ents2Label-mention-ngram: interacts directlyt_e2: trigger-arg-path: ubiquitinated:Positive_regulation prep_by [lemma='scf-skp2'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED phosphorylates thette1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cdk2'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=trigger nsubj [lemma='cdk2'] controllert-e2: ents2Label-mention-ngram: its destructiontVe2: trigger-arg-path: lemmatizedTrigger=trigger >prep_by [lemma='scf-skp2'] controllertMe2: trigger-arg-path: lemmatizedTrigger=trigger >prep_by Gene_or_gene_producttZe2: trigger-arg-path: triggers >prep_by [lemma='scf-skp2'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=trigger prep_by [lemma='scf-skp2'] controllert'e2: ents2Label-mention-ngram: inhibitortse2: trigger-arg-path: triggers:Positive_regulation prep_by controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: triggers its destructiontMe2: trigger-arg-path: lemmatizedTrigger=trigger prep_by [lemma='scf-skp2'] controller:Gene_or_gene_producttce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cdk2'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=trigger >prep_by [lemma='scf-skp2'] Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=trigger >prep_by controllertYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cdk2'] controllertGe2: trigger-arg-path: triggers prep_by controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: triggers itst2e2: ents2Label-mention-ngram: inhibitor SHARED andtke2: trigger-arg-path: lemmatizedTrigger=trigger >prep_by [lemma='scf-skp2'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cdk2'] controllert_e2: trigger-arg-path: triggers prep_by Gene_or_gene_productt*e2: ents2Label-mention-ngram: and triggerstpe2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nsubj [lemma='cdk2'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation prep_by [lemma='scf-skp2'] controller:Gene_or_gene_productte2: trigger: triggerst&e2: ents2Label-mention-ngram: triggerst/e2: args2Role-mention-ngram: destruction by thet\e2: trigger-arg-path: lemmatizedTrigger=trigger nsubj [lemma='cdk2'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: CDK inhibitor SHAREDtje2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >prep_by [lemma='scf-skp2'] controllerte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='cdk2'] controller:Gene_or_gene_producttPe2: trigger-arg-path: triggers:Positive_regulation >prep_by Gene_or_gene_producttje2: trigger-arg-path: Positive_regulation nsubj [lemma='cdk2'] Gene_or_gene_producttFe2: trigger-arg-path: triggers:Positive_regulation >prep_by controllert_e2: trigger-arg-path: triggers:Positive_regulation nsubj [lemma='cdk2'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >prep_by [lemma='scf-skp2'] Gene_or_gene_productthtrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and e2:triggers:Positive_regulationtPe2: trigger-arg-path: triggers:Positive_regulation conj_and [lemma='trigger'] e2:triggers:Positive_regulationtnsubj [lemma='cdk2'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: inhibitor SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation nsubj [lemma='cdk2'] controllertGe2: trigger-arg-path: triggers:Positive_regulation nsubj [lemma='cdk2'] controllertPe2: trigger-arg-path: Positive_regulation >prep_by [lemma='scf-skp2'] controllertne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='cdk2'] controller:Gene_or_gene_productt2e2: trigger-arg-path: triggers >prep_by controllert+e2: ents2Label-mention-ngram: CDK inhibitortprep_by Gene_or_gene_productt,e2: ents2Label-mention-ngram: destruction bytVe2: trigger-arg-path: Positive_regulation prep_by controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: the CDKt3e2: trigger-arg-path: triggers prep_by [lemma='scf-skp2'] Gene_or_gene_producttRe2: trigger-arg-path: Positive_regulation nsubj [lemma='cdk2'] controller:Gene_or_gene_productt[e2: trigger-arg-path: triggers:Positive_regulation prep_by controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: the CDKt7e2: ents2Label-mention-ngram: SHARED phosphorylates thet!e1: ents2Label-mention-ngram: CDKt(e2: args2Role-mention-ngram: destructiontWe2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >prep_by controllert-e2: args2Role-mention-ngram: and triggers itstKe2: trigger-arg-path: triggers prep_by [lemma='scf-skp2'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >prep_by [lemma='scf-skp2'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: the CDK inhibitortYe2: trigger-arg-path: triggers:Positive_regulation >prep_by [lemma='scf-skp2'] controllert+e1: ents2Label-mention-ngram: CDK inhibitort2e2: ents2Label-mention-ngram: CDK inhibitor SHAREDtWtrigger-to-trigger-path: e1:form a complex:Binding conj_and e2:bind:Bindingt~e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] theme:Gene_or_gene_productt{e1: trigger-arg-path: Binding nsubj [lemma='c-Myc'] theme:Gene_or_gene_producttue1: trigger-arg-path: Binding nsubj [lemma='c-Myc'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: enhancer binding factort5e2: args2Role-mention-ngram: transcription factor andt'e2: args2Role-mention-ngram: regions oft+e1: args2Role-mention-ngram: THEME can formt1e2: args2Role-mention-ngram: transcription factort%e2: ents2Label-mention-ngram: LEF-1 )t:e2: trigger-arg-path: Binding >nsubj [lemma='c-Myc'] themet2e2: args2Role-mention-ngram: the lymphoid enhancert.e1: ents2Label-mention-ngram: binding factor 1t)e2: args2Role-mention-ngram: and bind thet,e2: ents2Label-mention-ngram: binding factort/e2: ents2Label-mention-ngram: lymphoid enhancertFe2: trigger-arg-path: bind:Binding >dobj >prep_of Gene_or_gene_productt-e2: args2Role-mention-ngram: complex with thetAe2: trigger-arg-path: Binding >dobj >prep_of Gene_or_gene_productt$e2: args2Role-mention-ngram: ( LEF-1t,e2: args2Role-mention-ngram: factor and bindt2e2: trigger-arg-path: Binding >dobj >prep_of themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='c-Myc'] Gene_or_gene_producttLe2: trigger-arg-path: bind >nsubj [lemma='c-Myc'] theme:Gene_or_gene_producttNe2: trigger-arg-path: bind:Binding >nsubj [lemma='c-Myc'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: the promotertfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: the promoter regionst!e2: ents2Label-mention-ngram: 1 (tje1: trigger-arg-path: Binding prep_with [lemma='lef-1'] themetle2: trigger-arg-path: bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: form a complext(e2: ents2Label-mention-ngram: regions oftve2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: the promoter regionst]e1: trigger-arg-path: form a complex:Binding prep_with theme:Gene_or_gene_producttWe2: trigger-arg-path: bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] themet-e1: args2Role-mention-ngram: enhancer bindingt7e2: trigger-arg-path: bind:Binding >dobj >prep_of themetOe2: trigger-arg-path: bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] themetWe1: trigger-arg-path: form a complex:Binding prep_with Gene_or_gene_productt(e2: ents2Label-mention-ngram: factor 1 (t&e2: ents2Label-mention-ngram: and bindtae2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] themet+e2: args2Role-mention-ngram: regions of thetIe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of themet?e2: trigger-arg-path: bind:Binding >nsubj [lemma='c-Myc'] themet+e2: args2Role-mention-ngram: binding factort$e2: args2Role-mention-ngram: LEF-1 )t?e1: trigger-arg-path: form a complex:Binding prep_with [lemma='lef-1'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: factor 1 (txe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] Gene_or_gene_productt2e2: args2Role-mention-ngram: LEF-1 ) transcriptiont/e2: trigger-arg-path: bind >dobj >prep_of themet)e2: args2Role-mention-ngram: the lymphoidt,e2: ents2Label-mention-ngram: regions of thet?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='c-Myc'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='c-Myc'] Gene_or_gene_producttHe1: trigger-arg-path: form a complex:Binding prep_with themet6e1: args2Role-mention-ngram: lymphoid enhancer bindingt(e2: ents2Label-mention-ngram: factor andtDe2: trigger-arg-path: bind >dobj >prep_of theme:Gene_or_gene_producttye1: trigger-arg-path: Binding prep_with [lemma='lef-1'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt>e2: trigger-arg-path: bind >dobj >prep_of Gene_or_gene_productt.e1: args2Role-mention-ngram: lymphoid enhancert-e1: args2Role-mention-ngram: binding factor 1t/e1: ents2Label-mention-ngram: with the lymphoidtae2: trigger-arg-path: Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='lef-1'] themet e1: args2Role-mention-ngram: 1 (t.e2: args2Role-mention-ngram: bind the promotertLe2: trigger-arg-path: bind:Binding >dobj >prep_of theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: LEF-1t?e1: trigger-arg-path: form a complex:Binding nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: the lymphoid enhancert'e2: args2Role-mention-ngram: factor andt4e2: ents2Label-mention-ngram: ) transcription factort?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt1e2: ents2Label-mention-ngram: promoter regions oftge2: trigger-arg-path: Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: 1 ( LEF-1t3e1: ents2Label-mention-ngram: the lymphoid enhancert$e1: args2Role-mention-ngram: ( THEMEt&e2: args2Role-mention-ngram: 1 ( LEF-1t5e2: ents2Label-mention-ngram: enhancer binding factort(e1: ents2Label-mention-ngram: factor 1 (t.e2: args2Role-mention-ngram: with the lymphoidtXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='c-Myc'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: LEF-1t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='c-Myc'] themet3e2: ents2Label-mention-ngram: the lymphoid enhancertUe1: trigger-arg-path: form a complex prep_with theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: factor 1tfe1: trigger-arg-path: Binding nsubj [lemma='c-Myc'] themet e2: args2Role-mention-ngram: 1 (t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='lef-1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: the lymphoidt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='c-Myc'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: can form atqe1: trigger-arg-path: form a complex prep_with [lemma='lef-1'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of Gene_or_gene_productt)e2: args2Role-mention-ngram: the promotert/e2: ents2Label-mention-ngram: bind the promotert-e2: ents2Label-mention-ngram: SHARED can formtue1: trigger-arg-path: form a complex:Binding nsubj [lemma='c-Myc'] themetOe1: trigger-arg-path: form a complex prep_with Gene_or_gene_productt+e1: args2Role-mention-ngram: binding factortGe2: trigger-arg-path: Binding >dobj >prep_of theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='c-Myc'] themet6e2: args2Role-mention-ngram: lymphoid enhancer bindingt'e2: args2Role-mention-ngram: can form at%e2: args2Role-mention-ngram: bind thet4e1: args2Role-mention-ngram: enhancer binding factort'e1: args2Role-mention-ngram: factor 1 (t|e1: trigger-arg-path: form a complex nsubj [lemma='c-Myc'] Gene_or_gene_productt%e2: args2Role-mention-ngram: lymphoidt%e1: args2Role-mention-ngram: enhancert?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='lef-1'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: factor 1tde2: trigger-arg-path: bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: regionst?e1: trigger-arg-path: form a complex nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: LEF-1 ) transcriptiont*e2: ents2Label-mention-ngram: and bind thet?trigger-to-trigger-path: e1:form a complex:Binding conj_and [lemma='bind'] e2:bind:Bindingt%e1: args2Role-mention-ngram: can formtye1: trigger-arg-path: form a complex:Binding prep_with [lemma='lef-1'] themet-e2: ents2Label-mention-ngram: ) transcriptiont.e2: ents2Label-mention-ngram: enhancer bindingtAe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of themetRe2: trigger-arg-path: Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] themet3e2: args2Role-mention-ngram: ) transcription factortFe2: trigger-arg-path: bind >nsubj [lemma='c-Myc'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: lymphoid enhancer bindingte1: trigger-arg-path: Binding prep_with [lemma='lef-1'] theme:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] Gene_or_gene_productt+e2: args2Role-mention-ngram: THEME can formtie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] themet&e2: ents2Label-mention-ngram: bind thet%e1: args2Role-mention-ngram: lymphoidt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: lymphoid enhancert%e1: args2Role-mention-ngram: factor 1t0e2: args2Role-mention-ngram: promoter regions oft?e1: trigger-arg-path: form a complex prep_with [lemma='lef-1'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: ( LEF-1t7e2: trigger-arg-path: bind >nsubj [lemma='c-Myc'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='lef-1'] themet/e2: ents2Label-mention-ngram: with the lymphoidt.e2: ents2Label-mention-ngram: promoter regionst&e2: ents2Label-mention-ngram: lymphoidtIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='c-Myc'] themet^e2: trigger-arg-path: bind >dobj [lemma='region'] >prep_of [lemma='bcl2'] Gene_or_gene_productt,e2: args2Role-mention-ngram: ) transcriptiont?e1: trigger-arg-path: form a complex:Binding prep_with [lemma='lef-1'] Gene_or_gene_productt7shortest-path: aux [lemma='can']t`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='c-Myc'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: binding factor 1t&e1: ents2Label-mention-ngram: factor 1t6e2: ents2Label-mention-ngram: transcription factor andt&e1: ents2Label-mention-ngram: lymphoidt-e2: ents2Label-mention-ngram: factor and bindt$e2: args2Role-mention-ngram: regionst!e1: ents2Label-mention-ngram: 1 (t?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='lef-1'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED can formtme1: trigger-arg-path: form a complex nsubj [lemma='c-Myc'] themet.e2: args2Role-mention-ngram: lymphoid enhancert#e2: args2Role-mention-ngram: form atfe2: trigger-arg-path: bind:Binding >dobj [lemma='region'] >prep_of [lemma='bcl2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='lef-1'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: enhancer bindingtXe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of Gene_or_gene_productt7e1: ents2Label-mention-ngram: lymphoid enhancer bindingt.e1: args2Role-mention-ngram: with the lymphoidt'e1: args2Role-mention-ngram: can form atTe2: trigger-arg-path: bind:Binding >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: 1 ( GENE_OR_GENE_PRODUCTt(e1: ents2Label-mention-ngram: can form at*e1: ents2Label-mention-ngram: the lymphoidt.e1: ents2Label-mention-ngram: enhancer bindingt'e2: ents2Label-mention-ngram: ( LEF-1 )t@e1: trigger-arg-path: form a complex prep_with themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='c-Myc'] themet&e2: args2Role-mention-ngram: ( LEF-1 )t&e1: ents2Label-mention-ngram: can formt,e1: ents2Label-mention-ngram: binding factort%e2: args2Role-mention-ngram: and bindt?e1: trigger-arg-path: form a complex prep_with [lemma='lef-1'] Gene_or_gene_productt-e2: args2Role-mention-ngram: binding factor 1t&e1: args2Role-mention-ngram: 1 ( THEMEt4e2: args2Role-mention-ngram: enhancer binding factort-e2: args2Role-mention-ngram: promoter regionst*e2: ents2Label-mention-ngram: the lymphoidtQe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] Gene_or_gene_productt"e1: args2Role-mention-ngram: PAK ,t(e1: ents2Label-mention-ngram: not only at'e1: args2Role-mention-ngram: only a RactFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] themet*e1: ents2Label-mention-ngram: effector butt'e1: args2Role-mention-ngram: , which ist%e1: args2Role-mention-ngram: not onlyt#e1: args2Role-mention-ngram: only at#e1: ents2Label-mention-ngram: PAK ,t(e1: ents2Label-mention-ngram: , which ist'e1: ents2Label-mention-ngram: binds PAKt.e1: ents2Label-mention-ngram: SHARED binds PAKt&e1: ents2Label-mention-ngram: not onlyt,e1: ents2Label-mention-ngram: also interactst(e1: ents2Label-mention-ngram: only a Ract,e1: ents2Label-mention-ngram: a Rac effectort)e1: ents2Label-mention-ngram: is not onlyt'e1: args2Role-mention-ngram: not only at!e1: ents2Label-mention-ngram: Racthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: is nott.e1: ents2Label-mention-ngram: Rac effector butt)e1: ents2Label-mention-ngram: PAK , whichtIe1: trigger-arg-path: interacts >nsubj [lemma='rac'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_with [lemma='pix'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: Rac effectort^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] Gene_or_gene_producttMe1: trigger-arg-path: interacts >prep_with [lemma='pix'] Gene_or_gene_producttWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] theme:Gene_or_gene_productt[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: also interacts withtSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] themetOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] themet/e1: ents2Label-mention-ngram: effector but alsot(e1: args2Role-mention-ngram: is not onlyt-e1: args2Role-mention-ngram: Rac effector buttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] themetatrigger-to-trigger-path: e1:interacts:Binding >prep_with >rcmod e2:stimulates:Positive_activationtprep_with [lemma='pix'] themet#e1: args2Role-mention-ngram: is nott,e1: args2Role-mention-ngram: THEME binds PAKt)e1: args2Role-mention-ngram: which is nott(e1: args2Role-mention-ngram: PAK , whichtKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] themetfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] Gene_or_gene_productt:e1: trigger-arg-path: interacts >nsubj [lemma='rac'] themet0e1: args2Role-mention-ngram: also interacts withtle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pix'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interacts >prep_with [lemma='pix'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: Ractde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pix'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: binds PAK ,t+e1: args2Role-mention-ngram: a Rac effectort/e1: args2Role-mention-ngram: but also interactst%e1: args2Role-mention-ngram: which istUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pix'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: which is nott%e1: args2Role-mention-ngram: effectort%e1: args2Role-mention-ngram: but alsot&e1: ents2Label-mention-ngram: which istbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rac'] Gene_or_gene_productt+e1: args2Role-mention-ngram: also interactstBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rac'] themet&e1: ents2Label-mention-ngram: effectort(e1: args2Role-mention-ngram: binds PAK ,t#e1: ents2Label-mention-ngram: a Ract+e2: ents2Label-mention-ngram: with SHARED ,tZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rac'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: but also interactst$e1: ents2Label-mention-ngram: only at&e1: ents2Label-mention-ngram: but alsot)e1: args2Role-mention-ngram: effector butt"e1: args2Role-mention-ngram: a RactKe1: trigger-arg-path: Binding >prep_with [lemma='pix'] Gene_or_gene_producttOe1: trigger-arg-path: interacts >nsubj [lemma='rac'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:interacts:Binding >prep_with [lemma='pix'] >rcmod [lemma='stimulate'] e2:stimulates:Positive_activationt.e1: args2Role-mention-ngram: effector but alsot>e1: trigger-arg-path: interacts >prep_with [lemma='pix'] themet)e1: args2Role-mention-ngram: Rac effectort&e1: args2Role-mention-ngram: binds PAKt?trigger-to-trigger-path: e1:supports:Positive_regulation >conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110'] >vmod [lemma='disrupt'] e2:disrupt:Negative_regulationt5e1: ents2Label-mention-ngram: Ras-GDP supports SHAREDt8e1: ents2Label-mention-ngram: supports SHARED disruptiont{trigger-to-trigger-path: e1:supports:Positive_regulation >conj_but >nsubjpass >prep_of >vmod e2:disrupt:Negative_regulationtconj_but >nsubjpass >prep_oft?shortest-path: conj_but [lemma='determine'] >nsubjpass [lemma='selectivity'] >prep_of [lemma='mcp110']t-e1: ents2Label-mention-ngram: supports SHAREDt%e1: ents2Label-mention-ngram: disruptt$e1: args2Role-mention-ngram: disrupttAe2: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] themet`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] Familyt3e1: trigger-arg-path: disrupt >nsubj Generic_entityt#e2: ents2Label-mention-ngram: 1 andtTtrigger-to-trigger-path: e1:disrupt:Negative_regulation >dobj e2:interaction:Bindingt.e1: ents2Label-mention-ngram: between SHARED 1tMe2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-2'] themetce2: trigger-arg-path: interaction:Binding >prep_between [lemma='Beclin'] theme:Gene_or_gene_producttCe1: trigger-arg-path: disrupt:Negative_regulation >nsubj controllert^e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] theme:Familyt(e1: args2Role-mention-ngram: disrupt thetNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-2'] Familyt&e2: args2Role-mention-ngram: inhibitortPe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj controller:Generic_entitytJe1: trigger-arg-path: Negative_regulation >nsubj [lemma='they'] controllertYe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj Generic_entityt3e1: args2Role-mention-ngram: disrupt the CONTROLLEDt2e2: ents2Label-mention-ngram: its inhibitor SHAREDtUe2: trigger-arg-path: interaction >prep_between [lemma='Beclin'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED 1 andtse1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='they'] controller:Generic_entityt+e1: ents2Label-mention-ngram: its inhibitort*e2: ents2Label-mention-ngram: SHARED 1 andtme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Beclin'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: 1 and itst,e2: args2Role-mention-ngram: inhibitor THEMEtue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Beclin'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENERIC_ENTITY disrupt thetNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='Beclin'] themet%e2: ents2Label-mention-ngram: and itstde1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='they'] controllert/e1: ents2Label-mention-ngram: and its inhibitortWe2: trigger-arg-path: Binding >prep_between [lemma='Beclin'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj controller:Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj controllertNe1: trigger-arg-path: Negative_regulation >nsubj [lemma='they'] Generic_entityt,e2: args2Role-mention-ngram: between THEME 1t>e1: trigger-arg-path: disrupt >nsubj controller:Generic_entitytHe2: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] theme:Familyt.e2: args2Role-mention-ngram: and its inhibitortCshortest-path: dobj [lemma='interaction']t>e1: trigger-arg-path: disrupt >nsubj [lemma='they'] controllertYe1: trigger-arg-path: Negative_regulation >nsubj [lemma='they'] controller:Generic_entityt$e2: args2Role-mention-ngram: THEME 1t3e1: args2Role-mention-ngram: CONTROLLER disrupt thet/e1: trigger-arg-path: disrupt >nsubj controllerte1: trigger: disruptt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] themet_e1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='they'] controller:Generic_entityt/e1: args2Role-mention-ngram: CONTROLLER disruptt0e2: args2Role-mention-ngram: its inhibitor THEMEtjtrigger-to-trigger-path: e1:disrupt:Negative_regulation >dobj [lemma='interaction'] e2:interaction:BindingtXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Beclin'] themet4e1: ents2Label-mention-ngram: GENERIC_ENTITY disruptthe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='they'] Generic_entitytVe1: trigger-arg-path: disrupt:Negative_regulation >nsubj [lemma='they'] Generic_entityt/e2: ents2Label-mention-ngram: and its inhibitort$e2: args2Role-mention-ngram: and itstge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Beclin'] Gene_or_gene_producttMe1: trigger-arg-path: disrupt >nsubj [lemma='they'] controller:Generic_entitytTe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='they'] Generic_entitytoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Beclin'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] Familyt2e1: ents2Label-mention-ngram: its inhibitor SHAREDtEe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj Generic_entitytTe2: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-2'] theme:Familyt[e2: trigger-arg-path: interaction >prep_between [lemma='Beclin'] theme:Gene_or_gene_producttFe2: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] Familyt#e1: ents2Label-mention-ngram: 1 andt*e2: args2Role-mention-ngram: its inhibitortae1: trigger-arg-path: disrupt:Negative_regulation >nsubj [lemma='they'] controller:Generic_entitytWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] themet(e2: args2Role-mention-ngram: THEME 1 andtFe2: trigger-arg-path: interaction >prep_between [lemma='Beclin'] themet]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='Beclin'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: disrupt the interactiontEe2: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] themetQe2: trigger-arg-path: Binding >prep_between [lemma='Beclin'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: between SHARED 1tGe1: trigger-arg-path: disrupt:Negative_regulation >nsubj Generic_entitytBe2: trigger-arg-path: Binding >prep_between [lemma='Beclin'] themetfe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] theme:FamilytBe2: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] Familyt)e1: ents2Label-mention-ngram: disrupt thetBe1: trigger-arg-path: disrupt >nsubj [lemma='they'] Generic_entityt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Beclin'] themet"e2: args2Role-mention-ngram: 1 andtPe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='they'] controllertRe1: trigger-arg-path: disrupt:Negative_regulation >nsubj controller:Generic_entityt&e2: args2Role-mention-ngram: 1 and itst+e2: ents2Label-mention-ngram: its inhibitort'e2: ents2Label-mention-ngram: 1 and itstLe2: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] theme:FamilytRe1: trigger-arg-path: disrupt:Negative_regulation >nsubj [lemma='they'] controllertMe2: trigger-arg-path: interacts >prep_with [lemma='tcf'] Gene_or_gene_productt[e2: trigger-arg-path: interacts:Binding >prep_with [lemma='tcf'] theme:Gene_or_gene_producttBe2: trigger-arg-path: interacts >nsubj [lemma='it'] Generic_entitytPe2: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] theme:Generic_entityt;e2: trigger-arg-path: interacts >nsubj theme:Generic_entityt,e1: ents2Label-mention-ngram: , beta-catenint)e1: args2Role-mention-ngram: its receptortHe2: trigger-arg-path: interacts >nsubj [lemma='it'] theme:Generic_entitytKe1: trigger-arg-path: sequestered:Positive_activation >prep_upon >nn Familyt_e1: trigger-arg-path: sequestered >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlledt interceding-token ngrams: / axint6e1: ents2Label-mention-ngram: beta-catenin sequesteredt-interceding-token ngrams: degradation complextke1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon [lemma='interaction'] >nn [lemma='wnt'] Familyt)e1: args2Role-mention-ngram: beta-catenint?trigger-to-trigger-path: e1:sequestered:Positive_activation >prep_by [lemma='Coli'] >dep [lemma='release'] >prep_to [lemma='nucleus'] >rcmod [lemma='interact'] e2:interacts:Bindingt&interceding-token ngrams: re-localizedt$e1: ents2Label-mention-ngram: ligandt[e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon >nn Familyte1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] Familytntrigger-to-trigger-path: e1:sequestered:Positive_activation >prep_by >dep >prep_to >rcmod e2:interacts:Bindingt+e1: args2Role-mention-ngram: sequestered byt.e1: args2Role-mention-ngram: with its receptort=e2: trigger-arg-path: interacts:Binding >nsubj Generic_entitytBe1: trigger-arg-path: sequestered >prep_upon >nn controlled:Familyt+e1: args2Role-mention-ngram: its receptor ,tBshortest-path: prep_by >dep >prep_to >rcmod >nsubjtAe2: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] themet*e1: ents2Label-mention-ngram: its receptort-interceding-token ngrams: re-localized to thet#interceding-token ngrams: nucleus ,t0interceding-token ngrams: degradation complex istoe1: trigger-arg-path: sequestered:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] Familyt[e1: trigger-arg-path: sequestered >prep_upon [lemma='interaction'] >nn [lemma='wnt'] Familytprep_with [lemma='tcf'] themetRe1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon >nn controlled:Familyt(e1: ents2Label-mention-ngram: the FAMILYt#e1: args2Role-mention-ngram: ligandtUe2: trigger-arg-path: interacts:Binding >prep_with [lemma='tcf'] Gene_or_gene_productt.e1: args2Role-mention-ngram: CONTROLLED ligandt*e1: ents2Label-mention-ngram: beta-catenint5e2: trigger-arg-path: interacts >nsubj Generic_entityt,interceding-token ngrams: / axin degradationt5e1: args2Role-mention-ngram: beta-catenin sequesteredt)interceding-token ngrams: is released andtGe1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon >nn Familyt>e2: trigger-arg-path: interacts >prep_with [lemma='tcf'] themet&interceding-token ngrams: released andt)interceding-token ngrams: nucleus , wheret5e1: ents2Label-mention-ngram: receptor , beta-catenintKe1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon >nn controlledtlinterceding-tokens-full-span: / axin degradation complex is released and re-localized to the nucleus , wheret?e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlledte1: trigger: sequesteredtCe1: trigger-arg-path: Positive_activation >prep_upon >nn controlledt!interceding-token ngrams: nucleustJe1: trigger-arg-path: Positive_activation >prep_upon >nn controlled:Familytze1: trigger-arg-path: sequestered:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlled:FamilytQe2: trigger-arg-path: Binding >prep_with [lemma='tcf'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: ligand interactiontne1: trigger-arg-path: Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlled:Familyt7e1: args2Role-mention-ngram: , beta-catenin sequesteredtfe1: trigger-arg-path: sequestered >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlled:Familyt5e1: ents2Label-mention-ngram: ligand interaction withtfe1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon >nn controlled:Familytoe1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlledt%e1: args2Role-mention-ngram: with itst"interceding-token ngrams: releasedtce1: trigger-arg-path: Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] Familyt3interceding-token ngrams: released and re-localizedtFe2: trigger-arg-path: interacts:Binding >prep_with [lemma='tcf'] themetge1: trigger-arg-path: Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tcf'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: interaction with itst&e1: ents2Label-mention-ngram: with itst,e1: ents2Label-mention-ngram: its receptor ,t:e1: args2Role-mention-ngram: CONTROLLED ligand interactiont/e1: args2Role-mention-ngram: sequestered by thet?shortest-path: prep_by [lemma='Coli'] >dep [lemma='release'] >prep_to [lemma='nucleus'] >rcmod [lemma='interact'] >nsubj [lemma='it']t?e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlled:FamilytKe2: trigger-arg-path: Binding >prep_with [lemma='tcf'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: sequestered byt)e1: ents2Label-mention-ngram: sequesteredtOe1: trigger-arg-path: sequestered:Positive_activation >prep_upon >nn controlledtJe2: trigger-arg-path: interacts:Binding >nsubj [lemma='it'] Generic_entityt/e1: ents2Label-mention-ngram: with its receptortOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tcf'] themetSe2: trigger-arg-path: interacts >prep_with [lemma='tcf'] theme:Gene_or_gene_productt%interceding-token ngrams: the nucleust)interceding-token ngrams: re-localized tot%interceding-token ngrams: is releasedt8e1: ents2Label-mention-ngram: , beta-catenin sequesteredtinterceding-token ngrams: axint-interceding-token ngrams: complex is releasedt+e1: args2Role-mention-ngram: , beta-catenint0e1: ents2Label-mention-ngram: ligand interactiont_e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >prep_upon >nn controlledtve1: trigger-arg-path: lemmatizedTrigger=sequester >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlled:Familytfe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tcf'] Gene_or_gene_productt;e1: trigger-arg-path: sequestered >prep_upon >nn controlledt'interceding-token ngrams: the nucleus ,t1e1: args2Role-mention-ngram: interaction with itst7e1: ents2Label-mention-ngram: SHARED ligand interactiont0e1: ents2Label-mention-ngram: sequestered by thet?e1: trigger-arg-path: Positive_activation >prep_upon >nn Familyt9e1: ents2Label-mention-ngram: beta-catenin sequestered byt(e1: args2Role-mention-ngram: sequesteredt4e1: args2Role-mention-ngram: ligand interaction witht*interceding-token ngrams: axin degradationt'e1: args2Role-mention-ngram: receptor ,tse1: trigger-arg-path: sequestered:Positive_activation >prep_upon [lemma='interaction'] >nn [lemma='wnt'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tcf'] themet9e2: trigger-arg-path: interacts >nsubj [lemma='it'] themet+e1: ents2Label-mention-ngram: by the FAMILYtle2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tcf'] theme:Gene_or_gene_productt7e1: trigger-arg-path: sequestered >prep_upon >nn Familyt(interceding-token ngrams: to the nucleust(e1: ents2Label-mention-ngram: receptor ,t8e1: args2Role-mention-ngram: beta-catenin sequestered bytde2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tcf'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: SHARED ligandt*interceding-token ngrams: and re-localizedt-interceding-token ngrams: and re-localized tot4e1: args2Role-mention-ngram: receptor , beta-catenintCe2: trigger-arg-path: interacts:Binding >nsubj theme:Generic_entityt2interceding-token ngrams: axin degradation complextVe1: trigger-arg-path: sequestered:Positive_activation >prep_upon >nn controlled:Familytie1: trigger-arg-path: Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: which thentOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to >nn theme:Gene_or_gene_producttEe1: trigger-arg-path: Binding >prep_to >nn theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='complex'] >nn [lemma='cycline'] themetoe1: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind prep_to >nn theme:Gene_or_gene_producttKe1: trigger-arg-path: binds:Binding >prep_to >nn theme:Gene_or_gene_productt6e1: trigger-arg-path: binds prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to >nn Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn theme:Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttEe1: trigger-arg-path: binds prep_to >nn Gene_or_gene_producttEe1: trigger-arg-path: binds:Binding >prep_to >nn Gene_or_gene_productt)e1: args2Role-mention-ngram: , which thentRe1: trigger-arg-path: binds >prep_to [lemma='complex'] >nn [lemma='cycline'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to e2:complex:Bindingt8e1: trigger-arg-path: Binding prep_to >nn Gene_or_gene_producttZe1: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] themetre1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_producttae1: trigger-arg-path: binds >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] themet>e1: trigger-arg-path: binds:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] themetWtrigger-to-trigger-path: e1:binds:Binding >prep_to [lemma='complex'] e2:complex:Bindingtie1: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_producttce1: trigger-arg-path: Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_productt+e1: args2Role-mention-ngram: TRAF6 and TAK1t/e1: ents2Label-mention-ngram: TAK1 complex thatt)e1: args2Role-mention-ngram: complex thattTe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controller:Simple_chemicalt*e1: args2Role-mention-ngram: interleukin-1t3e1: ents2Label-mention-ngram: interleukin-1 inducedt`e1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] Gene_or_gene_producttVe1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='tak1'] controlledt/e1: args2Role-mention-ngram: with the formationt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllert4shortest-path: prepc_by >prep_with >prep_of >nnt[e1: trigger-arg-path: induced:Positive_activation >dobj >nn controlled:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] themetEe2: trigger-arg-path: complex >nn [lemma='tak1'] Gene_or_gene_productt8e1: trigger-arg-path: induced >nsubj >nn Simple_chemicalt:e1: ents2Label-mention-ngram: interleukin-1 induced SHAREDtNe2: trigger-arg-path: complex:Binding >nn [lemma='traf6'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: formation of thetXe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controllert{e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledte1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] themet9e1: ents2Label-mention-ngram: that mediates interleukin-1t1e1: ents2Label-mention-ngram: by interfering witht*e1: ents2Label-mention-ngram: of the TRAF6t*e1: ents2Label-mention-ngram: TAK1 complextCe1: trigger-arg-path: induced >nsubj >nn controller:Simple_chemicalt6e1: args2Role-mention-ngram: activation by interferingtee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tak1'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: TAK1tQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] themet7e2: trigger-arg-path: Binding >nn [lemma='traf6'] themet[e1: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicalt(e1: args2Role-mention-ngram: interferingt6e2: trigger-arg-path: complex >nn [lemma='tak1'] themet0e1: ents2Label-mention-ngram: with the formationt.e1: ents2Label-mention-ngram: and TAK1 complext?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicaltnn [lemma='traf6'] themetIe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn Simple_chemicalt0e1: args2Role-mention-ngram: by interfering withtLe2: trigger-arg-path: Binding >nn [lemma='traf6'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: the TRAF6 andt1e1: args2Role-mention-ngram: interfering with thetoe1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicaltSe2: trigger-arg-path: complex:Binding >nn [lemma='tak1'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: that mediatest-e1: args2Role-mention-ngram: formation of thet3e1: args2Role-mention-ngram: mediates interleukin-1t+e1: ents2Label-mention-ngram: activation byt8e1: args2Role-mention-ngram: that mediates interleukin-1the1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controller:Simple_chemicaltKe2: trigger-arg-path: complex >nn [lemma='tak1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='tak1'] Gene_or_gene_producttFe1: trigger-arg-path: induced:Positive_activation >dobj >nn controlledtwe1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='tak1'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:induced:Positive_activation >nsubj [lemma='activation'] >prepc_by [lemma='interfere'] >prep_with [lemma='formation'] >prep_of [lemma='complex'] e2:complex:Bindingtfe1: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicaltge1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] controllertje1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledtDe1: trigger-arg-path: Positive_activation >nsubj >nn Simple_chemicalt*e1: ents2Label-mention-ngram: complex thatt?shortest-path: prepc_by [lemma='interfere'] >prep_with [lemma='formation'] >prep_of [lemma='complex'] >nn [lemma='traf6']t4e1: ents2Label-mention-ngram: mediates interleukin-1t&e1: args2Role-mention-ngram: the TRAF6tle1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding >nn [lemma='traf6'] themetGe1: trigger-arg-path: induced >dobj >nn controlled:Gene_or_gene_productt-e1: args2Role-mention-ngram: and TAK1 complext2e1: trigger-arg-path: induced >dobj >nn controlledt,e1: ents2Label-mention-ngram: by interferingtTe2: trigger-arg-path: complex:Binding >nn [lemma='traf6'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL activationt,e1: ents2Label-mention-ngram: TRAF6 and TAK1tVe1: trigger-arg-path: induced >nsubj [lemma='activation'] >nn [lemma='nfb'] controllert.e1: args2Role-mention-ngram: TAK1 complex thatt&e1: args2Role-mention-ngram: TRAF6 andt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt#e1: ents2Label-mention-ngram: TRAF6tLe1: trigger-arg-path: induced:Positive_activation >nsubj >nn Simple_chemicalt%e1: args2Role-mention-ngram: and TAK1t{e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllertXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='traf6'] Gene_or_gene_producttotrigger-to-trigger-path: e1:induced:Positive_activation >nsubj >prepc_by >prep_with >prep_of e2:complex:Bindingt"e1: args2Role-mention-ngram: TRAF6t;e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL activation byt*e1: args2Role-mention-ngram: the TRAF6 andtMe2: trigger-arg-path: complex:Binding >nn [lemma='tak1'] Gene_or_gene_producttGe1: trigger-arg-path: induced:Positive_activation >nsubj >nn controllert)e1: args2Role-mention-ngram: TAK1 complextze1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicaltHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] themette1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: and TAK1t5e1: args2Role-mention-ngram: CONTROLLER activation bytge1: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicaltbe1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] controlledt+e1: ents2Label-mention-ngram: interleukin-1tfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Positive_activation >nsubj >nn controller:Simple_chemicalt=e1: args2Role-mention-ngram: interleukin-1 induced CONTROLLEDt;e1: args2Role-mention-ngram: mediates interleukin-1 inducedt3e1: trigger-arg-path: induced >nsubj >nn controllertke1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: complex that mediatestje1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controllert3e1: ents2Label-mention-ngram: complex that mediatest`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='traf6'] Gene_or_gene_productt*e1: args2Role-mention-ngram: activation bytwe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt!e1: args2Role-mention-ngram: TAK1t?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: the TRAF6t.e1: ents2Label-mention-ngram: interfering witht-e1: args2Role-mention-ngram: interfering withtdobj >nn Gene_or_gene_productt'e1: ents2Label-mention-ngram: TRAF6 andt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tak1'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: of the TRAF6tqe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt2e1: ents2Label-mention-ngram: interfering with thetFe2: trigger-arg-path: complex >nn [lemma='traf6'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: that mediatest>e2: trigger-arg-path: complex:Binding >nn [lemma='tak1'] themetle1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='activation'] >nn [lemma='nfb'] Simple_chemicaltre1: trigger-arg-path: Positive_activation >nsubj [lemma='activation'] >nn [lemma='nfb'] controller:Simple_chemicalt2e1: args2Role-mention-ngram: interleukin-1 inducedt6e2: trigger-arg-path: Binding >nn [lemma='tak1'] themetPe1: trigger-arg-path: induced:Positive_activation >dobj >nn Gene_or_gene_productt)e1: ents2Label-mention-ngram: interferingt|e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: complex >nn [lemma='traf6'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='tak1'] controlledt7e1: ents2Label-mention-ngram: activation by interferingt+e1: args2Role-mention-ngram: by interferingtFe2: trigger-arg-path: Binding >nn [lemma='traf6'] Gene_or_gene_producttWe1: trigger-arg-path: induced:Positive_activation >nsubj >nn controller:Simple_chemicalt,e1: ents2Label-mention-ngram: attenuates thetGe1: trigger-arg-path: attenuates >nsubj controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj [lemma='kinase'] controller:Gene_or_gene_producttDe1: trigger-arg-path: attenuates >dobj >prep_of Gene_or_gene_productt%e1: ents2Label-mention-ngram: TESK1 )tze1: trigger-arg-path: Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlled:Gene_or_gene_productt)e1: args2Role-mention-ngram: ) attenuatestTe1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj [lemma='kinase'] controllertae1: trigger-arg-path: attenuates:Negative_activation >nsubj [lemma='kinase'] Gene_or_gene_productt;e2: trigger-arg-path: interactions >nn Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj [lemma='kinase'] controllerte1: trigger: attenuatestinterceding-token ngrams: wayt.e1: ents2Label-mention-ngram: ) attenuates thetXe2: trigger-arg-path: interactions:Binding >nn [lemma='grb2'] theme:Gene_or_gene_productt#interceding-token ngrams: primarilytPe2: trigger-arg-path: interactions >nn [lemma='grb2'] theme:Gene_or_gene_productt+interceding-token ngrams: factor actions intWe1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj controllertFe1: trigger-arg-path: attenuates:Negative_activation >nsubj controllert'e1: ents2Label-mention-ngram: ( TESK1 )t?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interactionstie2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='grb2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj controller:Gene_or_gene_producttnn [lemma='spry2'] themetKe2: trigger-arg-path: interactions >nn [lemma='spry2'] Gene_or_gene_productt(e1: args2Role-mention-ngram: the abilitytce2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='grb2'] Gene_or_gene_productt'e1: args2Role-mention-ngram: ability oftUe1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj >prep_of Gene_or_gene_productt(e1: ents2Label-mention-ngram: ability oft,interceding-token ngrams: inhibit the growtht'interceding-token ngrams: growth factort?e1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlled:Gene_or_gene_productt,interceding-token ngrams: independent of itst+interceding-token ngrams: the growth factort3e1: args2Role-mention-ngram: attenuates the abilityt0interceding-token ngrams: activity and primarilytoe1: trigger-arg-path: Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] Gene_or_gene_producttIe2: trigger-arg-path: interactions:Binding >nn theme:Gene_or_gene_producttle1: trigger-arg-path: attenuates:Negative_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_producttQe2: trigger-arg-path: interactions >nn [lemma='spry2'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interactions:Binding >nn [lemma='grb2'] themetce1: trigger-arg-path: attenuates:Negative_activation >dobj >prep_of controlled:Gene_or_gene_producttDe2: trigger-arg-path: interactions:Binding >nn [lemma='spry2'] themet-e1: args2Role-mention-ngram: ) attenuates thet2interceding-token ngrams: primarily by interferingt*interceding-token ngrams: and primarily byt!interceding-token ngrams: actionst:e1: trigger-arg-path: attenuates >dobj >prep_of controlledt&interceding-token ngrams: activity andt4e1: ents2Label-mention-ngram: attenuates the abilitytMe1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj [lemma='kinase'] Gene_or_gene_producttCe1: trigger-arg-path: attenuates >nsubj [lemma='kinase'] controllert/interceding-token ngrams: growth factor actionst\e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='spry2'] Gene_or_gene_producttJe2: trigger-arg-path: interactions >nn [lemma='grb2'] Gene_or_gene_productt-interceding-token ngrams: by interfering witht+e1: args2Role-mention-ngram: CONTROLLER 1 (tbe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='spry2'] theme:Gene_or_gene_productt-interceding-token ngrams: its kinase activityt&e1: args2Role-mention-ngram: 1 ( TESK1t\e1: trigger-arg-path: attenuates >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlledt`e1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj >prep_of controlled:Gene_or_gene_productt?shortest-path: xcomp [lemma='inhibit'] >prep [lemma='in'] >dep [lemma='by'] >pcomp [lemma='interfere'] >prep_with [lemma='interaction'] >nn [lemma='spry2']t(interceding-token ngrams: by interferingtRe2: trigger-arg-path: interactions:Binding >nn [lemma='grb2'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='grb2'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: attenuatest/e2: args2Role-mention-ngram: THEME interactionst}e1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: attenuatestAe2: trigger-arg-path: interactions >nn theme:Gene_or_gene_productt2e1: trigger-arg-path: attenuates >nsubj controllertNe1: trigger-arg-path: attenuates:Negative_activation >dobj >prep_of controlledt4e2: trigger-arg-path: interactions:Binding >nn themetMe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='spry2'] themet$interceding-token ngrams: actions intte1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj >prep_of controlled:Gene_or_gene_producttpe1: trigger-arg-path: attenuates:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlledtwe1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj [lemma='ability'] >prep_of [lemma='spry2'] Gene_or_gene_producttWe1: trigger-arg-path: attenuates:Negative_activation >nsubj [lemma='kinase'] controllertCe2: trigger-arg-path: interactions:Binding >nn Gene_or_gene_productt*e1: ents2Label-mention-ngram: ) attenuatest?trigger-to-trigger-path: e1:attenuates:Negative_activation >xcomp [lemma='inhibit'] >prep [lemma='in'] >dep [lemma='by'] >pcomp [lemma='interfere'] >prep_with [lemma='interaction'] e2:interactions:Bindingtinterceding-token ngrams: a wayt4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 1tLe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='grb2'] themet&interceding-token ngrams: primarily byt'e1: ents2Label-mention-ngram: 1 ( TESK1t/e1: args2Role-mention-ngram: TESK1 ) attenuatest(interceding-token ngrams: factor actionst*interceding-token ngrams: interfering witht)interceding-token ngrams: way independentt_e1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj >prep_of controlledt?e1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlledt3e2: args2Role-mention-ngram: and THEME interactionstLe1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] controllert+e1: args2Role-mention-ngram: the ability oft[e1: trigger-arg-path: attenuates:Negative_activation >nsubj controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj >prep_of controlledt,interceding-token ngrams: way independent oft?interceding-tokens-full-span: to inhibit the growth factor actions in a way independent of its kinase activity and primarily by interfering witht$e1: args2Role-mention-ngram: ( TESK1t%e1: ents2Label-mention-ngram: ( TESK1t;e2: trigger-arg-path: interactions >nn [lemma='grb2'] themetae1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj Gene_or_gene_productt6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 1 (t/e1: ents2Label-mention-ngram: ability of SHAREDtCe1: trigger-arg-path: lemmatizedTrigger=attenuate >nsubj controllert'interceding-token ngrams: and primarilyt2e1: args2Role-mention-ngram: ability of CONTROLLEDtPe1: trigger-arg-path: attenuates:Negative_activation >nsubj Gene_or_gene_producttfe1: trigger-arg-path: attenuates >dobj [lemma='ability'] >prep_of [lemma='spry2'] Gene_or_gene_productt interceding-token ngrams: of itstze1: trigger-arg-path: attenuates:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: TESK1 ) attenuatest7e2: trigger-arg-path: Binding >nn [lemma='spry2'] themetCshortest-path: xcomp >prep >dep >pcomp >prep_with >nntMe1: trigger-arg-path: attenuates >nsubj [lemma='kinase'] Gene_or_gene_productt+e1: args2Role-mention-ngram: attenuates thetje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='spry2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: attenuates:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='spry2'] themetee1: trigger-arg-path: Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlledt%interceding-token ngrams: interferingtae1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_producttSe2: trigger-arg-path: interactions:Binding >nn [lemma='spry2'] Gene_or_gene_productt$interceding-token ngrams: its kinaset?e1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlled:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='spry2'] Gene_or_gene_producttvtrigger-to-trigger-path: e1:attenuates:Negative_activation >xcomp >prep >dep >pcomp >prep_with e2:interactions:Bindingtnsubj Gene_or_gene_producttXe1: trigger-arg-path: attenuates:Negative_activation >dobj >prep_of Gene_or_gene_productt-interceding-token ngrams: kinase activity andtTe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='grb2'] themet&e1: args2Role-mention-ngram: ( TESK1 )t&interceding-token ngrams: actions in atYe2: trigger-arg-path: interactions:Binding >nn [lemma='spry2'] theme:Gene_or_gene_productt+interceding-token ngrams: a way independentt$e1: args2Role-mention-ngram: TESK1 )tre1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj [lemma='kinase'] Gene_or_gene_producttCe2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT interactionst#e1: ents2Label-mention-ngram: TESK1t,e1: ents2Label-mention-ngram: the ability oftLe2: trigger-arg-path: Binding >nn [lemma='spry2'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >nsubj controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj >prep_of Gene_or_gene_productt"e1: args2Role-mention-ngram: TESK1t,e2: trigger-arg-path: interactions >nn themet'interceding-token ngrams: of its kinaset"interceding-token ngrams: in a waytme1: trigger-arg-path: lemmatizedTrigger=attenuate >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlledtXe1: trigger-arg-path: attenuates >nsubj [lemma='kinase'] controller:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='spry2'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: the abilityt?e1: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_activation >dobj [lemma='ability'] >prep_of [lemma='spry2'] Gene_or_gene_producttVe1: trigger-arg-path: Negative_activation >nsubj [lemma='kinase'] Gene_or_gene_producttqe1: trigger-arg-path: attenuates >dobj [lemma='ability'] >prep_of [lemma='spry2'] controlled:Gene_or_gene_productt$interceding-token ngrams: the growtht[e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='grb2'] Gene_or_gene_producttOe1: trigger-arg-path: attenuates >dobj >prep_of controlled:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] themetTe2: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='her2'] themetbe2: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_between [lemma='her2'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] themet[e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] themetZe2: trigger-arg-path: interactions >prep_between [lemma='her2'] theme:Gene_or_gene_producttEe1: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] themetxe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] themetEe2: trigger-arg-path: interactions >prep_between [lemma='her2'] themetre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttZe1: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] themetge2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_productt_e2: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_between [lemma='her2'] Gene_or_gene_producttae1: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] Gene_or_gene_producttge1: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] themetae2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] themet\e1: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] Gene_or_gene_producttZe1: trigger-arg-path: interactions >prep_between [lemma='her2'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interactions >prep_between [lemma='her2'] Gene_or_gene_productt\e2: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] themetRe2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfrviius'] themetEe1: trigger-arg-path: interactions >prep_between [lemma='her2'] themetJe2: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] themetMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] themetVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] themetee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] Gene_or_gene_producttTe1: trigger-arg-path: interactions >prep_between [lemma='her2'] Gene_or_gene_producttJe1: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] themet@e2: trigger-arg-path: Binding >prep_between [lemma='her2'] themetme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] themetpe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='her2'] theme:Gene_or_gene_producttYe1: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] Gene_or_gene_producttMe2: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] themetYe2: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfrviius'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='her2'] Gene_or_gene_productt_e1: trigger-arg-path: interactions >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfrviius'] Gene_or_gene_producttbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttZe2: trigger-arg-path: Binding >prep_between [lemma='egfrviius'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='her2'] theme:Gene_or_gene_producttrtrigger-to-trigger-path: e1:interaction:Generic_event agent >prep_in >nn controller:Simple_chemicalt"e2: ents2Label-mention-ngram: by at2e2: args2Role-mention-ngram: glucose deprivation ,tHe2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass controlledt$e2: args2Role-mention-ngram: glucosetQe2: trigger-arg-path: enhanced:Negative_regulation >agent >prep_in >nn controllertoe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass [lemma='interaction'] controlledt%e2: args2Role-mention-ngram: , namelytVe2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass controlled:Generic_eventt#e2: args2Role-mention-ngram: namelyt4e2: ents2Label-mention-ngram: by glucose deprivationt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controllertMe2: trigger-arg-path: Negative_regulation >agent >prep_in >nn Simple_chemicalt?e2: trigger-arg-path: Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controller:Simple_chemicalt?e2: trigger-arg-path: enhanced:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controllert?e2: trigger-arg-path: enhanced:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] Simple_chemicalt(e2: ents2Label-mention-ngram: a decreasetae2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass [lemma='interaction'] Generic_eventtAshortest-path: auxpass [lemma='be']t`trigger-to-trigger-path: e1:interaction:Generic_event agent >prep_in >nn controller:Simple_chemicalt'e2: args2Role-mention-ngram: a decreasetre2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass [lemma='interaction'] Generic_eventtXe2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='interaction'] Generic_eventt*e2: args2Role-mention-ngram: deprivation ,tVe2: trigger-arg-path: enhanced:Negative_regulation >agent >prep_in >nn Simple_chemicalt(e2: ents2Label-mention-ngram: by glucoset?e2: trigger-arg-path: Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] Simple_chemicalt?e2: trigger-arg-path: Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controllertbe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >agent >prep_in >nn controllertle2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventt\e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass Generic_eventtge2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass controlled:Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] Simple_chemicaltHe2: trigger-arg-path: Negative_regulation >agent >prep_in >nn controllertKe2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass Generic_eventt1e2: ents2Label-mention-ngram: enhanced by glucoset)e2: ents2Label-mention-ngram: deprivationt&e2: ents2Label-mention-ngram: , namelyt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controller:Simple_chemicalt3e2: args2Role-mention-ngram: by glucose deprivationt7e1-label: Generic_event + e2-label: Negative_regulationt*e2: args2Role-mention-ngram: a decrease int3e2: args2Role-mention-ngram: decrease in CONTROLLERt)e2: ents2Label-mention-ngram: namely by at+e2: ents2Label-mention-ngram: deprivation ,t?e2: trigger-arg-path: enhanced >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_in >nn controllert*e2: args2Role-mention-ngram: in CONTROLLERt!e2: args2Role-mention-ngram: by at3e2: ents2Label-mention-ngram: glucose deprivation ,t?e2: trigger-arg-path: enhanced >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controller:Simple_chemicaltUe2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='interaction'] controlledt'e2: ents2Label-mention-ngram: namely byt1e2: ents2Label-mention-ngram: glucose deprivationt=e2: trigger-arg-path: enhanced >agent >prep_in >nn controllert~e2: trigger-arg-path: enhanced >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controllertSe2: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_in >nn Simple_chemicalt%e2: ents2Label-mention-ngram: glucoset?e2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controllert?e2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] Simple_chemicaltce2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventtBe2: trigger-arg-path: Negative_regulation >nsubjpass Generic_eventt0e2: ents2Label-mention-ngram: in SIMPLE_CHEMICALt^e2: trigger-arg-path: enhanced:Negative_regulation >nsubjpass [lemma='interaction'] controlledt+e2: ents2Label-mention-ngram: a decrease intge2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >agent >prep_in >nn Simple_chemicalt(e2: args2Role-mention-ngram: deprivationt1e2: args2Role-mention-ngram: deprivation , namelyt0e2: args2Role-mention-ngram: glucose deprivationt*e2: args2Role-mention-ngram: by a decreasetYe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass controlledt(e2: args2Role-mention-ngram: namely by at0e2: args2Role-mention-ngram: enhanced by glucoset?e2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controller:Simple_chemicalt&e2: args2Role-mention-ngram: namely byt)e2: ents2Label-mention-ngram: , namely byt$e2: ents2Label-mention-ngram: namelyt(e2: args2Role-mention-ngram: , namely byt?e2: trigger-arg-path: enhanced:Negative_regulation >agent [lemma='decrease'] >prep_in [lemma='level'] >nn [lemma='glucose-6-phosphate'] controller:Simple_chemicaltMe2: trigger-arg-path: Negative_regulation >nsubjpass controlled:Generic_eventt^e2: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_in >nn controller:Simple_chemicalt+e2: ents2Label-mention-ngram: by a decreasetMe2: trigger-arg-path: enhanced >agent >prep_in >nn controller:Simple_chemicaltBe2: trigger-arg-path: enhanced >agent >prep_in >nn Simple_chemicalt2e2: ents2Label-mention-ngram: deprivation , namelyt9e2: ents2Label-mention-ngram: decrease in SIMPLE_CHEMICALt}e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_regulation >nsubjpass [lemma='interaction'] controlled:Generic_eventtae2: trigger-arg-path: enhanced:Negative_regulation >agent >prep_in >nn controller:Simple_chemicalt?e2: trigger-arg-path: Negative_regulation >nsubjpass controlledt.e1: args2Role-mention-ngram: via inhibition oft`e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controller:BioProcesstDe2: trigger-arg-path: mediated:Positive_regulation >nsubj BioProcesstde1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] controller:BioProcesst*e1: args2Role-mention-ngram: and stabilitytme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] BioProcesst5e1: args2Role-mention-ngram: p300 mediated CONTROLLEDtYe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] BioProcesst$e2: args2Role-mention-ngram: of p300t'e1: ents2Label-mention-ngram: stabilityt5e2: args2Role-mention-ngram: CONTROLLER and stabilitytYe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] BioProcesst*e2: args2Role-mention-ngram: and stabilityt.e2: args2Role-mention-ngram: and stability viat;e1: trigger-arg-path: mediated >nsubj controller:BioProcesst;e1: trigger-arg-path: Positive_regulation >nsubj BioProcesstAe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj BioProcesst7e1: ents2Label-mention-ngram: p300 mediated acetylationtHe2: trigger-arg-path: mediated >nsubj [lemma='transcription'] controllertUe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj BioProcesst+e2: ents2Label-mention-ngram: and stabilityt6e1: ents2Label-mention-ngram: stability via inhibitiont*e1: args2Role-mention-ngram: p300 mediatedt*e1: args2Role-mention-ngram: stability viatUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj BioProcesstSe2: trigger-arg-path: mediated >nsubj [lemma='transcription'] controller:BioProcesstAe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj BioProcesst.e2: ents2Label-mention-ngram: of p300 mediatedt2e2: ents2Label-mention-ngram: SHARED and stabilitytxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst0e2: trigger-arg-path: mediated >nsubj BioProcesst*e2: args2Role-mention-ngram: stability viat,e1: ents2Label-mention-ngram: via inhibitiont/e1: args2Role-mention-ngram: inhibition of p300t/e2: ents2Label-mention-ngram: and stability viat/e1: ents2Label-mention-ngram: via inhibition oftme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] controllertSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] controllertHe2: trigger-arg-path: mediated >nsubj [lemma='transcription'] BioProcesstHe1: trigger-arg-path: mediated >nsubj [lemma='transcription'] controllert5e1: args2Role-mention-ngram: stability via inhibitiontFe1: trigger-arg-path: Positive_regulation >nsubj controller:BioProcesst.e1: args2Role-mention-ngram: and stability viat-e2: args2Role-mention-ngram: of p300 mediatedt`e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj controller:BioProcesst\e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] controllert.e2: args2Role-mention-ngram: via inhibition oft+e2: ents2Label-mention-ngram: stability viatOe1: trigger-arg-path: mediated:Positive_regulation >nsubj controller:BioProcesst,e2: ents2Label-mention-ngram: via inhibitiont+e1: ents2Label-mention-ngram: and stabilityt+e2: args2Role-mention-ngram: via inhibitiont6e2: ents2Label-mention-ngram: stability via inhibitiont\e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] controllert.e1: ents2Label-mention-ngram: of p300 mediatedt0e1: ents2Label-mention-ngram: inhibition of p300t2e1: ents2Label-mention-ngram: SHARED and stabilitytxe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst%e2: ents2Label-mention-ngram: of p300tHe1: trigger-arg-path: mediated >nsubj [lemma='transcription'] BioProcesst^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesstLe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:BioProcesst/e2: ents2Label-mention-ngram: via inhibition oftme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] controllert'e2: ents2Label-mention-ngram: stabilitytDe1: trigger-arg-path: mediated:Positive_regulation >nsubj BioProcesstOe2: trigger-arg-path: mediated:Positive_regulation >nsubj controller:BioProcesst%e1: ents2Label-mention-ngram: of p300t$e1: args2Role-mention-ngram: of p300tde2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] controller:BioProcesstYe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] controllertLe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:BioProcesst\e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] BioProcesst5e2: args2Role-mention-ngram: stability via inhibitiontYe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='transcription'] controllertSe1: trigger-arg-path: mediated >nsubj [lemma='transcription'] controller:BioProcesstge1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst\e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] BioProcesst-e1: args2Role-mention-ngram: of p300 mediatedt+e1: args2Role-mention-ngram: via inhibitiontme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='transcription'] BioProcesst5e1: args2Role-mention-ngram: CONTROLLER and stabilitytge2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='transcription'] controller:BioProcesst;e2: trigger-arg-path: mediated >nsubj controller:BioProcesst0e2: ents2Label-mention-ngram: inhibition of p300tSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='transcription'] BioProcesst+e1: ents2Label-mention-ngram: stability viat0e1: trigger-arg-path: mediated >nsubj BioProcesst7e2: ents2Label-mention-ngram: p300 mediated acetylationt/e1: ents2Label-mention-ngram: and stability viat/e2: args2Role-mention-ngram: inhibition of p300t&e1: args2Role-mention-ngram: stabilityt&e2: args2Role-mention-ngram: stabilityt/e1: ents2Label-mention-ngram: SHARED and FAMILYtme2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt interceding-token ngrams: ( EE )t%interceding-token ngrams: translocatetQe1: trigger-arg-path: complex >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >nsubj [lemma='itsn1'] theme:Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT then bindstKe1: trigger-arg-path: complex >nn [lemma='pi3kc2beta'] Gene_or_gene_producttnn [lemma='pi3kc2beta'] themetfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='itsn1'] theme:Gene_or_gene_productt"interceding-token ngrams: as earlytge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt\e2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3kc2beta'] Gene_or_gene_producttinterceding-token ngrams: earlytGe2: trigger-arg-path: binds >nsubj [lemma='itsn1'] Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt?shortest-path: prep_to [lemma='site'] >prep_such_as [lemma='endosome'] >rcmod [lemma='bind'] >nsubj [lemma='itsn1']t&interceding-token ngrams: distal sitest$interceding-token ngrams: sites sucht*e2: args2Role-mention-ngram: then binds totVe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] themet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='itsn1'] Gene_or_gene_productt'interceding-token ngrams: such as earlyt)interceding-token ngrams: early endosomest'e2: args2Role-mention-ngram: THEME thentKe1: trigger-arg-path: Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_productt$interceding-token ngrams: EE ) wheret^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='itsn1'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3kc2beta'] themetinterceding-token ngrams: ( EEtVe2: trigger-arg-path: Binding >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:complex:Binding prep_to [lemma='site'] >prep_such_as [lemma='endosome'] >rcmod [lemma='bind'] e2:binds:Bindingt#interceding-token ngrams: endosomestnn [lemma='pi3kc2beta'] themet)interceding-token ngrams: to distal sitest+e2: ents2Label-mention-ngram: then binds tot-e2: args2Role-mention-ngram: THEME then bindstee2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt!interceding-token ngrams: ) wheretce1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_productt+interceding-token ngrams: distal sites sucht(e1: ents2Label-mention-ngram: and FAMILYtinterceding-token ngrams: EEt-interceding-token ngrams: then translocate tot,e1: ents2Label-mention-ngram: FAMILY complext(interceding-token ngrams: endosomes ( EEtPe2: trigger-arg-path: Binding >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt'interceding-token ngrams: sites such ast.interceding-token ngrams: may then translocatete2: outgoing: >amodt7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT thentee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_producttginterceding-tokens-full-span: may then translocate to distal sites such as early endosomes ( EE ) wheret8e2: trigger-arg-path: binds >nsubj [lemma='itsn1'] themetAe2: trigger-arg-path: Binding >prep_to [lemma='pi3kc2beta'] themetSe1: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_producttinterceding-token ngrams: sitestMe2: trigger-arg-path: binds >nsubj [lemma='itsn1'] theme:Gene_or_gene_productt>shortest-path: prep_to >prep_such_as >rcmod >nsubjtNe2: trigger-arg-path: binds >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt,interceding-token ngrams: as early endosomest/interceding-token ngrams: translocate to distalt+interceding-token ngrams: early endosomes (t]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='itsn1'] themet"interceding-token ngrams: may thent(interceding-token ngrams: translocate tot0e1: ents2Label-mention-ngram: and FAMILY complext@e2: trigger-arg-path: binds:Binding >nsubj [lemma='itsn1'] themet#interceding-token ngrams: to distalt*interceding-token ngrams: then translocatet%interceding-token ngrams: endosomes (tDe1: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='itsn1'] themetOe2: trigger-arg-path: binds:Binding >nsubj [lemma='itsn1'] Gene_or_gene_producttGe2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3kc2beta'] themet interceding-token ngrams: distaltXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='itsn1'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] themetatrigger-to-trigger-path: e1:complex:Binding prep_to >prep_such_as >rcmod e2:binds:Bindingtinterceding-token ngrams: EE )tTe2: trigger-arg-path: binds >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_producttYe1: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_productt?e2: trigger-arg-path: binds >prep_to [lemma='pi3kc2beta'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3kc2beta'] themet,e1: ents2Label-mention-ngram: SHARED at K320t"e1: ents2Label-mention-ngram: K320tye1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED at K320t\e2: trigger-arg-path: Positive_regulation >nn [lemma='pcaf'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='pcaf'] controllertvtrigger-to-trigger-path: e1:induces:Positive_regulation >dobj [lemma='acetylation'] e2:acetylation:Positive_regulationtTe2: trigger-arg-path: acetylation >nn [lemma='pcaf'] controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: K320tTe1: trigger-arg-path: induces >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: acetylation >nn [lemma='pcaf'] controllertKe1: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] controllert[e2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='pcaf'] Gene_or_gene_producttUshortest-path: dobj [lemma='acetylation'] >nn [lemma='pcaf']tSe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='hipk2'] controllertne1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hipk2'] Gene_or_gene_productt]e1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=acetylation >nn [lemma='pcaf'] controller:Gene_or_gene_producttSe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='pcaf'] controllert%e2: ents2Label-mention-ngram: at K320tee2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='pcaf'] controllert5e1: ents2Label-mention-ngram: induces SHARED mediatedt,e1: ents2Label-mention-ngram: induces SHAREDtIe2: trigger-arg-path: acetylation >nn [lemma='pcaf'] Gene_or_gene_producttUe1: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: at K320toe2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='pcaf'] Gene_or_gene_producttGe2: trigger-arg-path: Positive_regulation >nn [lemma='pcaf'] controllerthe2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='pcaf'] controller:Gene_or_gene_productt`e1: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >nn [lemma='pcaf'] controller:Gene_or_gene_productt`trigger-to-trigger-path: e1:induces:Positive_regulation >dobj e2:acetylation:Positive_regulationtIe1: trigger-arg-path: induces >nsubj [lemma='hipk2'] Gene_or_gene_productt]e2: trigger-arg-path: acetylation:Positive_regulation >nn [lemma='pcaf'] Gene_or_gene_productt?e1: trigger-arg-path: induces >nsubj [lemma='hipk2'] controllertAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces SHAREDthe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hipk2'] controllertQe2: trigger-arg-path: Positive_regulation >nn [lemma='pcaf'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='hipk2'] controllertDe2: trigger-arg-path: interaction:Binding >nn [lemma='Beclin'] themetbe2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kiius'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='bcl-2'] Familytce1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='bcl-2'] controllert\e2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kiius'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: 1 interactiontKe2: trigger-arg-path: interaction >nn [lemma='Beclin'] Gene_or_gene_productt;e1: trigger-arg-path: lemmatizedTrigger=block >nsubj Familyt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj Familyt0e2: args2Role-mention-ngram: THEME 1 interactiont2e2: ents2Label-mention-ngram: SHARED 1 interactiontVe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='bcl-2'] controller:Familytje1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='bcl-2'] controller:Familyt>e1: ents2Label-mention-ngram: PI3KIII and GENE_OR_GENE_PRODUCTtOe1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='bcl-2'] Familyt+e1: trigger-arg-path: blocked >nsubj Familyt6e1: trigger-arg-path: blocked >nsubj controller:FamilytZe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj controller:Familytne2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kiius'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >nn [lemma='Beclin'] themetke2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='Beclin'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kiius'] themetMe2: trigger-arg-path: Binding >nn [lemma='Beclin'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kiius'] theme:Gene_or_gene_producttBe1: trigger-arg-path: Negative_regulation >nsubj controller:Familytnn [lemma='Beclin'] themetce2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='Beclin'] theme:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=block >nsubj controller:FamilytOe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='bcl-2'] controllert+e1: ents2Label-mention-ngram: 1 interactiontee2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='Beclin'] Gene_or_gene_producttFe1: trigger-arg-path: blocked >nsubj [lemma='bcl-2'] controller:Familyt2e1: ents2Label-mention-ngram: SHARED 1 interactiontTe2: trigger-arg-path: interaction >prep_with [lemma='pi3kiius'] Gene_or_gene_producttQe2: trigger-arg-path: interaction >nn [lemma='Beclin'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='bcl-2'] controller:FamilytSe1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='bcl-2'] controllert*e1: ents2Label-mention-ngram: with PI3KIIItVe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='Beclin'] themet/e1: trigger-arg-path: blocked >nsubj controllertTtrigger-to-trigger-path: e1:blocked:Negative_regulation >dobj e2:interaction:BindingtCe1: trigger-arg-path: blocked:Negative_regulation >nsubj controllertte2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kiius'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interaction:Binding >nn [lemma='Beclin'] Gene_or_gene_producttVe2: trigger-arg-path: Binding >prep_with [lemma='pi3kiius'] theme:Gene_or_gene_producttjtrigger-to-trigger-path: e1:blocked:Negative_regulation >dobj [lemma='interaction'] e2:interaction:Bindingt0e1: ents2Label-mention-ngram: 1 interaction withtEe2: trigger-arg-path: interaction >prep_with [lemma='pi3kiius'] themet%e1: ents2Label-mention-ngram: PI3KIIIt6e1: ents2Label-mention-ngram: interaction with PI3KIIItZe2: trigger-arg-path: interaction >prep_with [lemma='pi3kiius'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kiius'] themet,e1: ents2Label-mention-ngram: FAMILY blockedt)e1: ents2Label-mention-ngram: PI3KIII andtKe1: trigger-arg-path: Negative_regulation >nsubj [lemma='bcl-2'] controllertNe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='Beclin'] themetJe1: trigger-arg-path: blocked:Negative_regulation >nsubj controller:FamilytOe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj Familyt]e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='Beclin'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_with [lemma='pi3kiius'] Gene_or_gene_producttZe1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='bcl-2'] controller:Familyt?e1: trigger-arg-path: blocked >nsubj [lemma='bcl-2'] controllertYe2: trigger-arg-path: interaction:Binding >nn [lemma='Beclin'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: FAMILY blocked SHAREDtAe2: trigger-arg-path: Binding >prep_with [lemma='pi3kiius'] themet.e1: ents2Label-mention-ngram: blocked SHARED 1t_e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='bcl-2'] FamilytGe1: trigger-arg-path: Negative_regulation >nsubj [lemma='bcl-2'] Familyt7e1: trigger-arg-path: Negative_regulation >nsubj Familyt*e2: args2Role-mention-ngram: 1 interactiontMe2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kiius'] themet0e2: ents2Label-mention-ngram: 1 interaction withtfe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kiius'] Gene_or_gene_productt/e2: args2Role-mention-ngram: 1 interaction witht.e1: ents2Label-mention-ngram: with PI3KIII andtVshortest-path: dobj [lemma='interaction'] >nn [lemma='Beclin']t;e1: trigger-arg-path: blocked >nsubj [lemma='bcl-2'] FamilytGe2: trigger-arg-path: Binding >nn [lemma='Beclin'] Gene_or_gene_producttbtrigger-to-trigger-path: e1:suppressed:Negative_regulation >dobj e2:inhibition:Negative_regulationtce1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicaltOe1: trigger-arg-path: suppressed >nsubj [lemma='ca'] controller:Simple_chemicaltXe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicalt7e1: args2Role-mention-ngram: suppressed this CONTROLLEDtse1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] controller:Simple_chemicalt+e1: ents2Label-mention-ngram: 2+ suppressedt,e1: args2Role-mention-ngram: suppressed thist!e1: args2Role-mention-ngram: thist)e1: ents2Label-mention-ngram: this SHAREDtDe1: trigger-arg-path: suppressed >nsubj [lemma='ca'] Simple_chemicaltXe1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] Simple_chemicalt2e1: ents2Label-mention-ngram: inhibition of SHAREDt/e1: ents2Label-mention-ngram: SHARED inhibitiont,e1: args2Role-mention-ngram: this CONTROLLEDt5e1: args2Role-mention-ngram: CONTROLLER 2+ suppressedt0e1: ents2Label-mention-ngram: 2+ suppressed thist?e1: trigger-arg-path: suppressed >nsubj [lemma='ca'] controllert/e1: args2Role-mention-ngram: 2+ suppressed thistOe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] controllert;e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL 2+ suppressedt4e1: ents2Label-mention-ngram: this SHARED inhibitiontMe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] Simple_chemicalt e1: ents2Label-mention-ngram: 2+t*e1: args2Role-mention-ngram: 2+ suppressedt/e1: ents2Label-mention-ngram: of SHARED bindingtce1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] controllert"e1: ents2Label-mention-ngram: thist-e1: ents2Label-mention-ngram: suppressed thist*e1: args2Role-mention-ngram: CONTROLLER 2+t2e1: ents2Label-mention-ngram: SHARED inhibition ofthe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_regulation >nsubj [lemma='ca'] Simple_chemicaltHe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ca'] controllert\shortest-path: dobj [lemma='inhibition'] >nn [lemma='calmodulin']te1: args2Role-mention-ngram: 2+t0e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL 2+tTe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] Simple_chemicaltwtrigger-to-trigger-path: e1:suppressed:Negative_regulation >dobj [lemma='inhibition'] e2:inhibition:Negative_regulationt4e1: ents2Label-mention-ngram: suppressed this SHAREDtSe1: trigger-arg-path: suppressed:Negative_regulation >nsubj [lemma='ca'] controllert_e1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='ca'] controller:Simple_chemicaltse2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationtae1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='mapk'] theme:Gene_or_gene_producttBe1: trigger-arg-path: interaction:Binding >nn [lemma='mapk'] themethe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='mapk'] controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ppar-gamma'] themet?e2: trigger-arg-path: mediated >dobj controlled:PhosphorylationtHe1: trigger-arg-path: interaction:Binding >nn [lemma='ppar-gamma'] themet&interceding-token ngrams: above ( i.e.tSe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='mapk'] controllertKe1: trigger-arg-path: Binding >nn [lemma='ppar-gamma'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ppar-gamma'] themetSe2: trigger-arg-path: mediated:Positive_regulation >dobj controlled:Phosphorylationt:e1: trigger-arg-path: interaction >nn [lemma='mapk'] themetbe2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt interceding-token ngrams: i.e. ,t4e2: trigger-arg-path: mediated >dobj Phosphorylationt!interceding-token ngrams: above (tNe2: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] Phosphorylationtce1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='mapk'] Gene_or_gene_producttEe1: trigger-arg-path: Binding >nn [lemma='mapk'] Gene_or_gene_productt@e1: trigger-arg-path: interaction >nn [lemma='ppar-gamma'] themetZe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] controlledtYe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj Phosphorylationtie1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ppar-gamma'] Gene_or_gene_productt?trigger-to-trigger-path: e1:interaction:Binding parataxis [lemma='mediate'] e2:mediated:Positive_regulationt[e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='mapk'] Gene_or_gene_producttme2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtLe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='mapk'] themetIe2: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] controlledtnn [lemma='ppar-gamma'] themetge1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ppar-gamma'] theme:Gene_or_gene_productt$interceding-token ngrams: i.e. , thetoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ppar-gamma'] theme:Gene_or_gene_producttjtrigger-to-trigger-path: e1:interaction:Binding parataxis e2:mediated:Positive_regulationtPe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlled:Phosphorylationt:interceding-tokens-full-span: described above ( i.e. , thet4shortest-path: parataxis >nsubjt]e1: trigger-arg-path: interaction:Binding >nn [lemma='ppar-gamma'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='mapk'] theme:Gene_or_gene_productt+interceding-token ngrams: described above (tOe1: trigger-arg-path: interaction >nn [lemma='ppar-gamma'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='mapk'] theme:Gene_or_gene_producttinterceding-token ngrams: i.e.tje2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] controlled:PhosphorylationtIe2: trigger-arg-path: mediated >nsubj [lemma='mapk'] Gene_or_gene_productt#interceding-token ngrams: describedtde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlled:Phosphorylationt]e2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] controlledt6e1: trigger-arg-path: Binding >nn [lemma='mapk'] themetHe2: trigger-arg-path: mediated:Positive_regulation >dobj PhosphorylationtWe1: trigger-arg-path: interaction:Binding >nn [lemma='ppar-gamma'] Gene_or_gene_productt interceding-token ngrams: ( i.e.t?shortest-path: parataxis [lemma='mediate'] >nsubj [lemma='mapk']t~e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtUe1: trigger-arg-path: interaction >nn [lemma='ppar-gamma'] theme:Gene_or_gene_productt"interceding-token ngrams: ( i.e. ,tae1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ppar-gamma'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='mapk'] themetOe1: trigger-arg-path: interaction >nn [lemma='mapk'] theme:Gene_or_gene_productt]e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='mapk'] Gene_or_gene_producttIe1: trigger-arg-path: interaction >nn [lemma='mapk'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] PhosphorylationtQe1: trigger-arg-path: interaction:Binding >nn [lemma='mapk'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >nn [lemma='ppar-gamma'] theme:Gene_or_gene_productt?e2: trigger-arg-path: mediated >nsubj [lemma='mapk'] controllert)interceding-token ngrams: described abovetYe2: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] controlled:PhosphorylationtEe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj PhosphorylationtTe2: trigger-arg-path: mediated >nsubj [lemma='mapk'] controller:Gene_or_gene_producttWe1: trigger-arg-path: interaction:Binding >nn [lemma='mapk'] theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] controlledt^e2: trigger-arg-path: disruption:Negative_regulation >nn [lemma='mcp110'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn [lemma='mcp110'] controllert(e2: ents2Label-mention-ngram: disruptiont'e2: args2Role-mention-ngram: disruptiontMe2: trigger-arg-path: disruption:Negative_regulation >nn Gene_or_gene_productte2: trigger: disruptiont9e2: trigger-arg-path: disruption >nn Gene_or_gene_productt+e2: ents2Label-mention-ngram: disruption oftRe2: trigger-arg-path: lemmatizedTrigger=disruption >nn [lemma='mcp110'] controllertAe2: trigger-arg-path: lemmatizedTrigger=disruption >nn controllertge2: trigger-arg-path: lemmatizedTrigger=disruption >nn [lemma='mcp110'] controller:Gene_or_gene_productt`trigger-to-trigger-path: e1:supports:Positive_regulation >dobj e2:disruption:Negative_regulationt2e2: ents2Label-mention-ngram: SHARED disruption oftJe2: trigger-arg-path: disruption >nn [lemma='mcp110'] Gene_or_gene_producttSe2: trigger-arg-path: Negative_regulation >nn [lemma='mcp110'] Gene_or_gene_producttvshortest-path: dobj [lemma='disruption'] >nn [lemma='mcp110']t/e2: ents2Label-mention-ngram: SHARED disruptiontVe2: trigger-arg-path: lemmatizedTrigger=disruption >nn controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER disruptiont.e2: args2Role-mention-ngram: disruption of thet_e2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn [lemma='mcp110'] controller:Gene_or_gene_productt@e2: trigger-arg-path: disruption >nn [lemma='mcp110'] controllertIe2: trigger-arg-path: Negative_regulation >nn [lemma='mcp110'] controllertutrigger-to-trigger-path: e1:supports:Positive_regulation >dobj [lemma='disruption'] e2:disruption:Negative_regulationt^e2: trigger-arg-path: Negative_regulation >nn [lemma='mcp110'] controller:Gene_or_gene_producttXe2: trigger-arg-path: disruption:Negative_regulation >nn controller:Gene_or_gene_producttie2: trigger-arg-path: disruption:Negative_regulation >nn [lemma='mcp110'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: disruption of thetCe2: trigger-arg-path: disruption:Negative_regulation >nn controllertUe2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn controllertKe2: trigger-arg-path: lemmatizedTrigger=disruption >nn Gene_or_gene_producttUe2: trigger-arg-path: disruption >nn [lemma='mcp110'] controller:Gene_or_gene_productt/e2: trigger-arg-path: disruption >nn controllert,e2: ents2Label-mention-ngram: the SHARED andtTe2: trigger-arg-path: disruption:Negative_regulation >nn [lemma='mcp110'] controllertpe2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn [lemma='mcp110'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=disruption >nn [lemma='mcp110'] Gene_or_gene_productt*e2: args2Role-mention-ngram: disruption oftje2: trigger-arg-path: lemmatizedTrigger=disruption:Negative_regulation >nn controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: CONTROLLER disruption oftDe2: trigger-arg-path: disruption >nn controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] Gene_or_gene_producttPe1: trigger-arg-path: phosphorylate:Positive_regulation nsubj controllert~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] Gene_or_gene_producttNe2: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controllertZe2: trigger-arg-path: interacts:Positive_regulation >nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt1e2: trigger-arg-path: interacts >nsubj controllertje2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttnsubj controllertBe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj controllertOe2: trigger-arg-path: interacts:Positive_regulation >nsubj Gene_or_gene_productt*e1: args2Role-mention-ngram: with DNMT1 totQe1: trigger-arg-path: phosphorylate nsubj controller:Gene_or_gene_producttYe2: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttZe1: trigger-arg-path: phosphorylate:Positive_regulation nsubj Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3beta'] controllertle1: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] Gene_or_gene_producttwe1: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttbe1: trigger-arg-path: phosphorylate nsubj [lemma='gsk3beta'] controllert*e1: args2Role-mention-ngram: to CONTROLLEDtse2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj [lemma='gsk3beta'] Gene_or_gene_producttXe2: trigger-arg-path: interacts:Positive_regulation >nsubj [lemma='gsk3beta'] controllertve1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controllertbe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj controllertbe2: trigger-arg-path: interacts:Positive_regulation >nsubj [lemma='gsk3beta'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: DNMT1 to phosphorylatet?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gsk3beta'] controllertWe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_producttme2: trigger-arg-path: interacts:Positive_regulation >nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt2e1: ents2Label-mention-ngram: interacts with DNMT1tFe1: trigger-arg-path: phosphorylate nsubj Gene_or_gene_producttetrigger-to-trigger-path: e1:phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controllertXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3beta'] Gene_or_gene_productt}e1: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttee1: trigger-arg-path: phosphorylate:Positive_regulation nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controllertVe2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj controllertke2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj controller:Gene_or_gene_productt?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='gsk3beta'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: DNMT1 to CONTROLLEDt%e1: args2Role-mention-ngram: DNMT1 totce2: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj controller:Gene_or_gene_producttEe2: trigger-arg-path: interacts:Positive_regulation >nsubj controllert&e1: ents2Label-mention-ngram: DNMT1 totle1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj Gene_or_gene_producttre1: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: Ser410txtrigger-to-trigger-path: e1:phosphorylate:Positive_regulation nsubj Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: interacts with DNMT1tDe2: trigger-arg-path: interacts >nsubj [lemma='gsk3beta'] controllert'e1: args2Role-mention-ngram: with DNMT1tFe2: trigger-arg-path: interacts >nsubj controller:Gene_or_gene_productthe1: trigger-arg-path: Positive_regulation nsubj [lemma='gsk3beta'] controllert(e1: ents2Label-mention-ngram: with DNMT1t+e1: ents2Label-mention-ngram: with DNMT1 tot'e1: ents2Label-mention-ngram: at Ser410t~e2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj [lemma='gsk3beta'] controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='gsk3beta'] controllert.e1: ents2Label-mention-ngram: SHARED at Ser410t`e2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj Gene_or_gene_productt,e1: ents2Label-mention-ngram: by the bindingtIe2: trigger-arg-path: binding >prep_of [lemma='ngf'] Gene_or_gene_producttae1: trigger-arg-path: Positive_activation >prep_to [lemma='trka'] controlled:Gene_or_gene_productt5e2: trigger-arg-path: binding prep_to themetRe2: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='trka'] theme:Gene_or_gene_producttVe1: trigger-arg-path: activated:Positive_activation >prep_to [lemma='trka'] controlledtne2: trigger-arg-path: binding:Binding prep_to [lemma='trka'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=activate >prep_to [lemma='trka'] controlledtWe2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=activate >prep_to [lemma='trka'] Gene_or_gene_productt3e1: trigger-arg-path: activated >prep_to controlledtqe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='trka'] themetIe2: trigger-arg-path: Binding >prep_of [lemma='ngf'] Gene_or_gene_productt-e1: args2Role-mention-ngram: activated by thette2: trigger-arg-path: binding:Binding prep_to [lemma='trka'] theme:Gene_or_gene_productt=e1: trigger-arg-path: activated >prep_to Gene_or_gene_productt:e2: trigger-arg-path: binding >prep_of [lemma='ngf'] themet\e2: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_producttGe1: trigger-arg-path: Positive_activation >prep_to Gene_or_gene_productt`e1: trigger-arg-path: activated:Positive_activation >prep_to [lemma='trka'] Gene_or_gene_productt_e2: trigger-arg-path: binding:Binding prep_to [lemma='trka'] themetxe2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='trka'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='trka'] themetce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] Gene_or_gene_producttke1: trigger-arg-path: activated:Positive_activation >prep_to [lemma='trka'] controlled:Gene_or_gene_producttgtrigger-to-trigger-path: e1:activated:Positive_activation >prep_by [lemma='binding'] e2:binding:Bindingtge1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to [lemma='trka'] controlledtDe1: trigger-arg-path: lemmatizedTrigger=activate >prep_to controlledtle2: trigger-arg-path: binding prep_to [lemma='trka'] theme:Gene_or_gene_producttQe2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] Gene_or_gene_productt=e1: trigger-arg-path: Positive_activation >prep_to controlledtBe1: trigger-arg-path: activated >prep_to [lemma='trka'] controlledtJe2: trigger-arg-path: binding prep_to theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: the bindingtWe1: trigger-arg-path: activated >prep_to [lemma='trka'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] themet+e1: args2Role-mention-ngram: by the bindingtGe1: trigger-arg-path: activated:Positive_activation >prep_to controlledtbe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to Gene_or_gene_productt:e2: trigger-arg-path: Binding >prep_of [lemma='ngf'] themetDe2: trigger-arg-path: binding prep_to Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='trka'] Gene_or_gene_producttLe1: trigger-arg-path: activated >prep_to [lemma='trka'] Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: the binding oft5e2: trigger-arg-path: Binding prep_to themetQe1: trigger-arg-path: activated:Positive_activation >prep_to Gene_or_gene_producttWe2: trigger-arg-path: Binding prep_to [lemma='trka'] themetXe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to controlledtOe2: trigger-arg-path: binding >prep_of [lemma='ngf'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binding:Binding prep_to Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=activate >prep_to controlled:Gene_or_gene_producttUtrigger-to-trigger-path: e1:activated:Positive_activation >prep_by e2:binding:Bindingtfe2: trigger-arg-path: Binding prep_to [lemma='trka'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=activate >prep_to [lemma='trka'] controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: the bindingtie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to [lemma='trka'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: Positive_activation >prep_to [lemma='trka'] controlledtde2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding prep_to Gene_or_gene_producttBe2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] themetJe2: trigger-arg-path: Binding prep_to theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] themet[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_productt=e2: trigger-arg-path: binding:Binding prep_to themetVe1: trigger-arg-path: Positive_activation >prep_to [lemma='trka'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='trka'] theme:Gene_or_gene_producttle2: trigger-arg-path: Binding prep_to [lemma='trka'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=activate >prep_to Gene_or_gene_producttHe1: trigger-arg-path: activated >prep_to controlled:Gene_or_gene_productt*e1: args2Role-mention-ngram: of CONTROLLERtOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themetWe2: trigger-arg-path: binding prep_to [lemma='trka'] themetfe2: trigger-arg-path: binding prep_to [lemma='trka'] Gene_or_gene_producttRe1: trigger-arg-path: Positive_activation >prep_to controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: activated by thetGe2: trigger-arg-path: lemmatizedTrigger=binding prep_to themetVe2: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_productt,e1: ents2Label-mention-ngram: the binding oftqe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >prep_to [lemma='trka'] Gene_or_gene_productt\e1: trigger-arg-path: activated:Positive_activation >prep_to controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: binding of CONTROLLERt$interceding-token ngrams: Moreover ,t&e2: ents2Label-mention-ngram: and ERK2t(interceding-token ngrams: T205A mutant .t%e2: ents2Label-mention-ngram: ERK2 byt)e2: args2Role-mention-ngram: transfectiontle2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controllert(e1: args2Role-mention-ngram: kinase deadt$interceding-token ngrams: . Moreovert,e1: ents2Label-mention-ngram: but not kinaset*e2: args2Role-mention-ngram: ERK2 by siRNAt'e1: ents2Label-mention-ngram: , but nott2e2: ents2Label-mention-ngram: trametinib treatmentt2e2: args2Role-mention-ngram: siRNA transfection ortXe1: trigger-arg-path: increased >nsubj [lemma='ha-erk1'] controller:Gene_or_gene_producttYe2: trigger-arg-path: Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controller:Gene_or_gene_producttDe2: trigger-arg-path: Negative_regulation >nsubj >prep_of controllert6e2: args2Role-mention-ngram: significantly reduced thet[e2: trigger-arg-path: reduced >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controllert0e2: ents2Label-mention-ngram: siRNA transfectiontle1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ha-erk1'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: dead mutantt(e2: args2Role-mention-ngram: and ERK2 byt+e1: ents2Label-mention-ngram: dead mutant ,t#interceding-token ngrams: the T205At/e1: args2Role-mention-ngram: kinase dead mutanttLe2: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of controllert.e1: ents2Label-mention-ngram: mutant , greatlyt/e2: args2Role-mention-ngram: siRNA transfectiontTe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ha-erk1'] controllert(e2: ents2Label-mention-ngram: trametinibtge2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controllert-e2: ents2Label-mention-ngram: transfection ort,e1: args2Role-mention-ngram: not kinase deadtNe2: trigger-arg-path: Negative_regulation >nsubj >prep_of Gene_or_gene_producttpe2: trigger-arg-path: reduced >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controller:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , butt&e1: args2Role-mention-ngram: , greatlyt2e1: args2Role-mention-ngram: greatly increased thet+e2: ents2Label-mention-ngram: ERK2 by siRNAt%e2: args2Role-mention-ngram: by siRNAt[interceding-tokens-full-span: but not the T205A mutant . Moreover , depletion of endogenoustbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha-erk1'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: greatly increased thet*e1: args2Role-mention-ngram: increased thet'e2: args2Role-mention-ngram: trametinibt2e2: args2Role-mention-ngram: by siRNA transfectiont}e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ha-erk1'] controller:Gene_or_gene_productt%interceding-token ngrams: but not thetie1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ha-erk1'] controller:Gene_or_gene_producttnsubj [lemma='ha-erk1'] controllert0e1: ents2Label-mention-ngram: kinase dead mutantt(e1: ents2Label-mention-ngram: not kinaset?e1: ents2Label-mention-ngram: increased the poly-ubiquitinationt!e1: args2Role-mention-ngram: deadtWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha-erk1'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: but nott*e1: args2Role-mention-ngram: dead mutant ,t7e2: ents2Label-mention-ngram: significantly reduced thet&interceding-token ngrams: depletion oft3e2: args2Role-mention-ngram: reduced the CONTROLLEDt-e1: args2Role-mention-ngram: mutant , greatlytoe2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controllert4e2: args2Role-mention-ngram: treatment significantlyt$e1: args2Role-mention-ngram: but nott0e2: args2Role-mention-ngram: CONTROLLER and ERK2t!e2: args2Role-mention-ngram: ERK2t.e1: args2Role-mention-ngram: greatly increasedt3e2: ents2Label-mention-ngram: siRNA transfection ort8e1: ents2Label-mention-ngram: the poly-ubiquitination oft)e2: ents2Label-mention-ngram: reduced thet*e2: args2Role-mention-ngram: or trametinibt&e2: ents2Label-mention-ngram: by siRNAt'e1: args2Role-mention-ngram: not kinaset?e2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controller:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ha-erk1'] Gene_or_gene_productt'interceding-token ngrams: not the T205At$e1: ents2Label-mention-ngram: mutantt%interceding-token ngrams: , depletiont'e1: ents2Label-mention-ngram: , greatlyt^e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ha-erk1'] Gene_or_gene_producttVe2: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of Gene_or_gene_productt1e1: ents2Label-mention-ngram: , greatly increasedt-e1: ents2Label-mention-ngram: not kinase deadt.interceding-token ngrams: Moreover , depletiont4e2: args2Role-mention-ngram: or trametinib treatmentt?e2: args2Role-mention-ngram: trametinib treatment significantlyt"interceding-token ngrams: mutant .t%e1: args2Role-mention-ngram: mutant ,t$interceding-token ngrams: endogenoust?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: transfection or trametinibt+interceding-token ngrams: mutant . Moreovert'interceding-token ngrams: of endogenoust"interceding-token ngrams: Moreovert;e1: ents2Label-mention-ngram: poly-ubiquitination of SHAREDtqe2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: mutant ,t+e2: ents2Label-mention-ngram: or trametinibt=e2: ents2Label-mention-ngram: treatment significantly reducedt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controllert0e1: args2Role-mention-ngram: , greatly increasedt5e1: ents2Label-mention-ngram: the poly-ubiquitinationt3e2: ents2Label-mention-ngram: by siRNA transfectiontinterceding-token ngrams: T205At?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controller:Gene_or_gene_producttye2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: reduced the ubiquitinationtMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha-erk1'] controllertre2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: but not kinaset"e1: ents2Label-mention-ngram: deadtWe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ha-erk1'] controllert1e1: ents2Label-mention-ngram: poly-ubiquitinationtae2: trigger-arg-path: reduced:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] Gene_or_gene_producttCe1: trigger-arg-path: increased >nsubj [lemma='ha-erk1'] controllert*e2: ents2Label-mention-ngram: transfectiont&interceding-token ngrams: T205A mutantt7e2: args2Role-mention-ngram: transfection or trametinibtae1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ha-erk1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: reduced thet$e1: args2Role-mention-ngram: greatlyt|e2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] controller:Gene_or_gene_productt1interceding-token ngrams: depletion of endogenoust)e1: ents2Label-mention-ngram: kinase deadtMe1: trigger-arg-path: increased >nsubj [lemma='ha-erk1'] Gene_or_gene_productt#e1: args2Role-mention-ngram: mutantt@e2: ents2Label-mention-ngram: trametinib treatment significantlyt1e2: args2Role-mention-ngram: trametinib treatmentt%e2: args2Role-mention-ngram: and ERK2t"e2: args2Role-mention-ngram: siRNAt5e2: ents2Label-mention-ngram: treatment significantlyt&interceding-token ngrams: . Moreover ,t5e2: ents2Label-mention-ngram: or trametinib treatmentt4e1: ents2Label-mention-ngram: poly-ubiquitination oft"e2: ents2Label-mention-ngram: ERK2t/e1: ents2Label-mention-ngram: greatly increasedt!interceding-token ngrams: not thet+e1: ents2Label-mention-ngram: increased thet*interceding-token ngrams: the T205A mutanttge2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of Gene_or_gene_productt5e1: args2Role-mention-ngram: increased the CONTROLLEDt]e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >prep_of controllertee2: trigger-arg-path: reduced >nsubj [lemma='depletion'] >prep_of [lemma='erk1'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: dead mutantt#e2: ents2Label-mention-ngram: siRNAt)e2: ents2Label-mention-ngram: and ERK2 byt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and ERK2t&e1: args2Role-mention-ngram: , but nott(interceding-token ngrams: , depletion oft%e1: ents2Label-mention-ngram: greatlytQe2: trigger-arg-path: promotes:Negative_activation >dobj >nn Gene_or_gene_producttMe1: trigger-arg-path: mediated:Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] controlledtde2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >nsubj [lemma='rnf2'] controllertBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT promotes SHAREDt,interceding-token ngrams: degradation . RYBPt3e2: trigger-arg-path: promotes >dobj >nn controlledtLe1: trigger-arg-path: mediated >dobj [lemma='ubiquitination'] Ubiquitinationt!interceding-token ngrams: MDM2 totDe2: trigger-arg-path: promotes:Negative_activation >nsubj controllertXe2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >nn controlledtXe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj Ubiquitinationtme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dobj [lemma='ubiquitination'] controlledt_e2: trigger-arg-path: Negative_activation >nsubj [lemma='rnf2'] controller:Gene_or_gene_productt>e1: trigger-arg-path: mediated dobj [lemma='ubiquitination'] UbiquitinationtKe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj Gene_or_gene_producttge1: trigger-arg-path: mediated:Positive_regulation dobj controlledtSe1: trigger-arg-path: mediated dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='ubiquitination'] Ubiquitinationt(interceding-token ngrams: ubiquitinationtWe2: trigger-arg-path: promotes >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtWe1: trigger-arg-path: mediated >dobj [lemma='ubiquitination'] controlled:UbiquitinationtNe2: trigger-arg-path: promotes:Negative_activation >nsubj Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=mediate nsubj controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=mediate nsubj Gene_or_gene_productt(interceding-token ngrams: RYBP interactstYe1: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='ubiquitination'] controlledtke1: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='ubiquitination'] controlled:UbiquitinationtJe1: trigger-arg-path: lemmatizedTrigger=mediate dobj Ubiquitinationtce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_producttGe1: trigger-arg-path: mediated:Positive_regulation >dobj Ubiquitinationtbe1: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] controlled:UbiquitinationtRe1: trigger-arg-path: mediated:Positive_regulation >dobj controlled:UbiquitinationtUe1: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='rnf2'] controllertde1: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='rnf2'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtOe1: trigger-arg-path: Positive_regulation dobj >nn controlled:Gene_or_gene_producttTe2: trigger-arg-path: promotes >nsubj [lemma='rnf2'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='rnf2'] Gene_or_gene_productt/e1: trigger-arg-path: mediated nsubj controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >nn Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >nsubj Gene_or_gene_producttDe1: trigger-arg-path: Positive_regulation dobj [lemma='ubiquitination'] Ubiquitinationte1: trigger-arg-path: Positive_regulation >dobj Ubiquitinationtee2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='rnf2'] controller:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT promotestIe2: trigger-arg-path: promotes >nsubj [lemma='rnf2'] Gene_or_gene_productt)interceding-token ngrams: and degradationt]e2: trigger-arg-path: promotes:Negative_activation >nsubj [lemma='rnf2'] Gene_or_gene_productt'interceding-token ngrams: decrease MDM2t\e2: trigger-arg-path: promotes:Negative_activation >dobj >nn controlled:Gene_or_gene_productt&interceding-token ngrams: with MDM2 tot@e1: trigger-arg-path: lemmatizedTrigger=mediate dobj [lemma='degradation'] >nn [lemma='p53'] controlledt9e1: trigger-arg-path: mediated nsubj controller:Gene_or_gene_producttJe2: trigger-arg-path: Negative_activation >nsubj [lemma='rnf2'] controllert3e1: trigger-arg-path: mediated >dobj Ubiquitinationtbe2: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtme2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj >nn controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >nsubj controllertye2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >nsubj [lemma='rnf2'] controller:Gene_or_gene_productt=e2: trigger-arg-path: promotes >dobj >nn Gene_or_gene_productt-interceding-token ngrams: interacts with MDM2t0interceding-token ngrams: decrease MDM2 mediatedt*interceding-token ngrams: . RYBP interactstWe1: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt/e1: trigger-arg-path: mediated >dobj controlledt*interceding-token ngrams: to decrease MDM2tue2: trigger-arg-path: promotes:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: degradation .tRe1: trigger-arg-path: mediated:Positive_regulation dobj controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt5interceding-token ngrams: mediated p53 ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_producttae2: trigger-arg-path: promotes >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: promotes >nsubj [lemma='rnf2'] controllertje2: trigger-arg-path: lemmatizedTrigger=promote:Negative_activation >nsubj controller:Gene_or_gene_productt>e1: trigger-arg-path: mediated >dobj controlled:Ubiquitinationtwe2: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlled:UbiquitinationtHe1: trigger-arg-path: mediated >dobj [lemma='ubiquitination'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='rnf2'] controller:Gene_or_gene_producttHe1: trigger-arg-path: mediated dobj [lemma='ubiquitination'] controlled:UbiquitinationtSe1: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] controlledtce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlled:UbiquitinationtGe2: trigger-arg-path: promotes:Negative_activation >dobj >nn controlledt'interceding-token ngrams: MDM2 mediatedt}e2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttDCSSPATH: ROOT >vmod >prep_to >vmod ++ ROOT >xcomp >dobj >vmod >advclt2interceding-token ngrams: p53 ubiquitination whiletPe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='rnf2'] controllertDe1: trigger-arg-path: mediated dobj controlledtIe1: trigger-arg-path: Positive_regulation >dobj controlled:UbiquitinationtXe1: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='rnf2'] Gene_or_gene_productt,interceding-token ngrams: p53 ubiquitinationtle2: trigger-arg-path: promotes >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt-interceding-token ngrams: RYBP interacts witht&interceding-token ngrams: mediated p53t\e1: trigger-arg-path: mediated:Positive_regulation dobj [lemma='ubiquitination'] controlled:Ubiquitinationt\e1: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='ubiquitination'] controlledtEe1: trigger-arg-path: initiating:Positive_activation dobj [lemma='ulk1'] controlledt*interceding-token ngrams: . When nutrientst;e1: trigger-arg-path: initiating >dobj Gene_or_gene_producttOinterceding-tokens-full-span: ( reviewed in ) . When nutrients are sufficient ,t6e1: ents2Label-mention-ngram: initiating kinase SHAREDt$interceding-token ngrams: sufficientt"interceding-token ngrams: ) . WhentIe1: trigger-arg-path: Positive_activation >dobj [lemma='ulk1'] controlledtFe1: trigger-arg-path: initiating >dobj controlled:Gene_or_gene_productt1e1: trigger-arg-path: initiating >dobj controlledt'e1: args2Role-mention-ngram: initiatingtPe1: trigger-arg-path: lemmatizedTrigger=initiate >dobj [lemma='ulk1'] controlledt:e1: trigger-arg-path: Positive_activation dobj controlledtUe1: trigger-arg-path: initiating >dobj [lemma='ulk1'] controlled:Gene_or_gene_productt1e1: trigger-arg-path: initiating dobj [lemma='ulk1'] controlled:Gene_or_gene_productt9e1: args2Role-mention-ngram: initiating kinase CONTROLLEDtde1: trigger-arg-path: initiating:Positive_activation dobj [lemma='ulk1'] Gene_or_gene_productt8CSSPATH: ROOT >appos >vmod >dobj >vmod ++ ROOT >conj_andt'interceding-token ngrams: nutrients aretPe1: trigger-arg-path: initiating dobj [lemma='ulk1'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation dobj controlled:Gene_or_gene_producttZe1: trigger-arg-path: initiating:Positive_activation >dobj controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER initiatingtje1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation >dobj controlled:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=initiate dobj Gene_or_gene_productt%interceding-token ngrams: reviewed int.e1: args2Role-mention-ngram: kinase CONTROLLEDtie1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation dobj [lemma='ulk1'] Gene_or_gene_productt9e1: args2Role-mention-ngram: CONTROLLER initiating kinasetNe1: trigger-arg-path: Positive_activation dobj [lemma='ulk1'] Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=initiate >dobj controlledtYe1: trigger-arg-path: initiating:Positive_activation dobj [lemma='ulk1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation >dobj controlledtie1: trigger-arg-path: initiating:Positive_activation >dobj [lemma='ulk1'] controlled:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation >dobj [lemma='ulk1'] controlled:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=initiate >dobj Gene_or_gene_productt#interceding-token ngrams: nutrientstUe1: trigger-arg-path: lemmatizedTrigger=initiate:Positive_activation dobj Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=initiate dobj [lemma='ulk1'] controlledt3e1: ents2Label-mention-ngram: BIOPROCESS initiatingtinterceding-token ngrams: in )t*interceding-token ngrams: are sufficient ,tNe1: trigger-arg-path: Positive_activation dobj [lemma='ulk1'] controlled:Gene_or_gene_producttEe1: trigger-arg-path: initiating dobj [lemma='ulk1'] controlledt`e1: trigger-arg-path: lemmatizedTrigger=initiate nn [lemma='p65'] Gene_or_gene_productt:e1: trigger-arg-path: heterodimer >nn Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='p65'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: NF-kappaBtCe2: ents2Label-mention-ngram: NF-kappaB allows GENE_OR_GENE_PRODUCTt&e2: args2Role-mention-ngram: NF-kappaBt.e2: args2Role-mention-ngram: allows CONTROLLEDtoe2: trigger-arg-path: lemmatizedTrigger=allow >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controllert2interceding-token ngrams: chromatin association oftbe2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='p300'] controlled:Gene_or_gene_producttBe1: trigger-arg-path: heterodimer:Binding >nn Gene_or_gene_producttTe1: trigger-arg-path: heterodimer dobj Gene_or_gene_producttEe1: trigger-arg-path: heterodimer nn [lemma='p65'] themetIe2: trigger-arg-path: Positive_activation >dobj [lemma='p300'] controlledtRe2: trigger-arg-path: lemmatizedTrigger=allow >nsubj >prep_of Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='p65'] theme:Gene_or_gene_producttDe1: trigger-arg-path: Binding >nn [lemma='p65'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='p300'] controlled:Gene_or_gene_productt!e2: args2Role-mention-ngram: fromt.e2: ents2Label-mention-ngram: active NF-kappaBtAe1: trigger-arg-path: Binding nn [lemma='p65'] themetUe2: trigger-arg-path: allows:Positive_activation >nsubj >prep_of Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='p300'] Gene_or_gene_producttAe1: trigger-arg-path: heterodimer:Binding >nn [lemma='p65'] themetWe1: trigger-arg-path: lemmatizedTrigger=heterodimer nn [lemma='p65'] theme:Gene_or_gene_productt4interceding-token ngrams: at the NF-kappaB-regulatedt`e1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controllert)e2: ents2Label-mention-ngram: from activet?e2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controllert-e2: trigger-arg-path: allows >dobj controlledt1interceding-token ngrams: promoter . Displacementt1interceding-token ngrams: the NF-kappaB-regulatedt3e1: trigger-arg-path: heterodimer:Binding >nn themetZe1: trigger-arg-path: heterodimer nsubj >prep_of Gene_or_gene_productt7e2: trigger-arg-path: allows >nsubj >prep_of controllerte1: trigger: heterodimert%interceding-token ngrams: of HDAC3 attLe1: trigger-arg-path: lemmatizedTrigger=heterodimer >nn Gene_or_gene_productt.e2: ents2Label-mention-ngram: NF-kappaB allowst?e2: trigger-arg-path: lemmatizedTrigger=allow >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controller:Gene_or_gene_productt+e1: trigger-arg-path: heterodimer >nn themethe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='p65'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='p65'] Gene_or_gene_productt3CSSPATH: ROOT >advcl >advmod >advcl >nsubj ++ ROOT tinterceding-token ngrams: HDAC3tKe2: trigger-arg-path: allows:Positive_activation >dobj Gene_or_gene_productt|e2: trigger-arg-path: allows:Positive_activation >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=allow >nsubj >prep_of controllertdobj [lemma='p300'] controlledt3e2: args2Role-mention-ngram: CONTROLLER from activetfe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >nsubj >prep_of Gene_or_gene_producttZe2: trigger-arg-path: allows:Positive_activation >dobj [lemma='p300'] Gene_or_gene_productt#e2: args2Role-mention-ngram: activetFe2: trigger-arg-path: allows >dobj [lemma='p300'] Gene_or_gene_productt2e2: args2Role-mention-ngram: from active NF-kappaBtye2: trigger-arg-path: lemmatizedTrigger=allow >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=heterodimer >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: active NF-kappaB allowst&interceding-token ngrams: HDAC3 at thet>e2: trigger-arg-path: lemmatizedTrigger=allow >dobj controlledtVe1: trigger-arg-path: Binding nsubj >prep_of controller:Gene_or_gene_producttee2: trigger-arg-path: allows:Positive_activation >dobj [lemma='p300'] controlled:Gene_or_gene_productt(e2: args2Role-mention-ngram: from activetNe2: trigger-arg-path: Positive_activation >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] Gene_or_gene_producttVe1: trigger-arg-path: heterodimer:Binding >nn [lemma='p65'] theme:Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation >dobj [lemma='p300'] controlled:Gene_or_gene_productt$e2: ents2Label-mention-ngram: allowstCe1: trigger-arg-path: lemmatizedTrigger=heterodimer nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] Gene_or_gene_producttQe2: trigger-arg-path: allows >dobj [lemma='p300'] controlled:Gene_or_gene_productt,e2: args2Role-mention-ngram: CONTROLLER fromt-e2: args2Role-mention-ngram: active NF-kappaBtte1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding nn theme:Gene_or_gene_producttNe1: trigger-arg-path: heterodimer >nn [lemma='p65'] theme:Gene_or_gene_producttYe2: trigger-arg-path: Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: fromt-interceding-token ngrams: NF-kappaB-regulatedt8interceding-token ngrams: NF-kappaB-regulated promoter .tNe1: trigger-arg-path: heterodimer:Binding nsubj >prep_of controllertRe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj controlledtZe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn theme:Gene_or_gene_producttHe1: trigger-arg-path: heterodimer:Binding >nn theme:Gene_or_gene_producttBe2: trigger-arg-path: allows >dobj controlled:Gene_or_gene_productt-e2: args2Role-mention-ngram: NF-kappaB allowstKe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT from activet_e1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding dobj controlledt]e2: trigger-arg-path: lemmatizedTrigger=allow >nsubj >prep_of controller:Gene_or_gene_producttLe2: trigger-arg-path: allows >nsubj >prep_of controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: allowst%interceding-token ngrams: associationtDe2: trigger-arg-path: Positive_activation >nsubj >prep_of controllert3e2: ents2Label-mention-ngram: from active NF-kappaBt=e1: trigger-arg-path: lemmatizedTrigger=heterodimer >nn themetbe1: trigger-arg-path: heterodimer:Binding dobj Gene_or_gene_producttKe2: trigger-arg-path: allows:Positive_activation >nsubj >prep_of controllertinterceding-tokens-full-span: binds to the promoter , IKKalpha remains associated with the chromatin and phosphorylates both p65 at Ser536 and SMRT at Ser2410 to prevent the recruitment and chromatin association of HDAC3 at the NF-kappaB-regulated promoter . Displacement oftHe2: trigger-arg-path: lemmatizedTrigger=allow >dobj Gene_or_gene_productt9e2: ents2Label-mention-ngram: allows GENE_OR_GENE_PRODUCTt.interceding-token ngrams: association of HDAC3tSe2: trigger-arg-path: lemmatizedTrigger=allow >dobj controlled:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=heterodimer nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='p300'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=heterodimer nn [lemma='p65'] themetSe2: trigger-arg-path: Positive_activation >dobj [lemma='p300'] Gene_or_gene_productt/interceding-token ngrams: chromatin associationt:interceding-token ngrams: the NF-kappaB-regulated promotert9e1: trigger-arg-path: heterodimer:Binding nn [lemma='p65'] themetqe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt(interceding-token ngrams: association oftTe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn Gene_or_gene_productt7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT fromtPe2: trigger-arg-path: allows:Positive_activation >dobj [lemma='p300'] controlledtse2: trigger-arg-path: allows >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME heterodimertXe1: trigger-arg-path: lemmatizedTrigger=heterodimer nn themetPe1: trigger-arg-path: Binding dobj controlled:Gene_or_gene_productt"interceding-token ngrams: HDAC3 attke2: trigger-arg-path: Positive_activation >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controllert@e1: trigger-arg-path: heterodimer nn [lemma='p65'] Gene_or_gene_productt&interceding-token ngrams: Displacementtae2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='p300'] controlledt^e2: trigger-arg-path: allows >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] controllertMe2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='p300'] controlledthe2: trigger-arg-path: allows >nsubj [lemma='displacement'] >prep_of [lemma='hdac3'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj controlled:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] Gene_or_gene_producttinterceding-token ngrams: Thet0e1: ents2Label-mention-ngram: of nucleotide-freet/e1: args2Role-mention-ngram: of nucleotide-freet5e1: trigger-arg-path: binding >prep_of >prep_to themetle1: trigger-arg-path: Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt%interceding-token ngrams: complex mayt&interceding-token ngrams: lipid kinaset#interceding-token ngrams: its lipidtWe1: trigger-arg-path: Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] themetqe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] themet%interceding-token ngrams: Ras complextDe1: trigger-arg-path: binding >prep_of >prep_to Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] themet?interceding-tokens-full-span: inhibits its lipid kinase activity . The PI3KC2beta and Ras complex may then translocate to distal sites such as early endosomes ( EE ) wheret,interceding-token ngrams: The PI3KC2beta andt=e1: trigger-arg-path: binding:Binding >prep_of >prep_to themet5e1: args2Role-mention-ngram: nucleotide-free THEME tot)interceding-token ngrams: Ras complex mayt,interceding-token ngrams: PI3KC2beta and RastRe1: trigger-arg-path: binding:Binding >prep_of >prep_to theme:Gene_or_gene_productt(interceding-token ngrams: The PI3KC2betat?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_producttfe1: trigger-arg-path: Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: FAMILY to SHAREDtJe1: trigger-arg-path: binding >prep_of >prep_to theme:Gene_or_gene_productt*interceding-token ngrams: its lipid kinaset$interceding-token ngrams: PI3KC2betat5e1: args2Role-mention-ngram: of nucleotide-free THEMEt7e1: ents2Label-mention-ngram: of nucleotide-free FAMILYt7e1: args2Role-mention-ngram: binding of nucleotide-freet:CSSPATH: ROOT >nsubj ++ ROOT >prep_to >prep_such_as >rcmodtfe1: trigger-arg-path: binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] Gene_or_gene_producttWe1: trigger-arg-path: binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] themet(interceding-token ngrams: PI3KC2beta andtle1: trigger-arg-path: binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: binding of nucleotide-freette1: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: nucleotide-free FAMILY totLe1: trigger-arg-path: binding:Binding >prep_of >prep_to Gene_or_gene_productt_e1: trigger-arg-path: binding:Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] themet!interceding-token ngrams: and Rast/interceding-token ngrams: lipid kinase activityt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ra'] >prep_to [lemma='pi3kc2beta'] Gene_or_gene_producttinterceding-token ngrams: lipidt*interceding-token ngrams: . The PI3KC2betat$interceding-token ngrams: activity .t(interceding-token ngrams: activity . Thet,interceding-token ngrams: inhibits its lipidt)interceding-token ngrams: and Ras complext+interceding-token ngrams: kinase activity .t*interceding-token ngrams: complex may thentinterceding-token ngrams: . Thet4e1: ents2Label-mention-ngram: nucleotide-free FAMILYt)e2: args2Role-mention-ngram: downregulatet-e2: args2Role-mention-ngram: downregulate thet2e2: ents2Label-mention-ngram: may downregulate thet)interceding-token ngrams: , and increasest!e2: ents2Label-mention-ngram: p27t'e2: ents2Label-mention-ngram: D1 and Rbt%e2: ents2Label-mention-ngram: and p27t?e2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controllert4e2: ents2Label-mention-ngram: and Rb phosphorylationtbe2: trigger-arg-path: downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controllert:e1: args2Role-mention-ngram: CONTROLLER treatment inhibitst?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: Rb phosphorylationt$e2: ents2Label-mention-ngram: and Rbtae1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controllertfe2: trigger-arg-path: downregulate:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Gene_or_gene_productt&interceding-token ngrams: Upregulationtce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER and p27t*interceding-token ngrams: p27 expression .tQe2: trigger-arg-path: downregulate:Negative_regulation >nsubj >prep_of controllertje1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controllert-e2: args2Role-mention-ngram: may downregulatet,interceding-token ngrams: and p27 expressiontwe2: trigger-arg-path: downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj >prep_of Gene_or_gene_productt/e1: ents2Label-mention-ngram: expression and Rbtce2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj >prep_of controllert$interceding-token ngrams: of p21 andt|e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='ltf'] controller:Gene_or_gene_productt>e1: trigger-arg-path: inhibits >nsubj >nn Gene_or_gene_productt)e2: ents2Label-mention-ngram: and p27 mayt9e2: ents2Label-mention-ngram: downregulate the expressiont/e1: args2Role-mention-ngram: treatment inhibitst~e2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj >prep_of Gene_or_gene_productt(interceding-token ngrams: . Upregulationtxe2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttte1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controller:Gene_or_gene_productt%interceding-token ngrams: p21 and p27t*e2: ents2Label-mention-ngram: of SHARED D1t~e2: trigger-arg-path: Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controller:Gene_or_gene_productt'interceding-token ngrams: levels of p21tse2: trigger-arg-path: Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: Rb phosphorylationt]e1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn controller:Gene_or_gene_producttIe1: trigger-arg-path: inhibits >nsubj >nn controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: and p27t e2: args2Role-mention-ngram: p27t(interceding-token ngrams: p27 expressiontie2: trigger-arg-path: Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controllertEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT treatment inhibitst0e1: ents2Label-mention-ngram: treatment inhibitstge1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='ltf'] controllert+e2: ents2Label-mention-ngram: SHARED D1 andt interceding-token ngrams: of p21t'e2: ents2Label-mention-ngram: SHARED D1t'interceding-token ngrams: and increasestinterceding-token ngrams: p21t#interceding-token ngrams: levels oft[e2: trigger-arg-path: downregulate:Negative_regulation >nsubj >prep_of Gene_or_gene_productt+interceding-token ngrams: . Upregulation oft1e2: args2Role-mention-ngram: p27 may downregulatette2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controllertve2: trigger-arg-path: downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controllert(e2: args2Role-mention-ngram: and p27 mayt%e2: ents2Label-mention-ngram: p27 mayt&interceding-token ngrams: expression .tle2: trigger-arg-path: downregulate >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] Gene_or_gene_productt2e2: ents2Label-mention-ngram: p27 may downregulatet e1: ents2Label-mention-ngram: Rbt`e1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='ltf'] Gene_or_gene_productt`interceding-tokens-full-span: , and increases levels of p21 and p27 expression . Upregulation oft+e1: ents2Label-mention-ngram: D1 expressiont/e1: ents2Label-mention-ngram: D1 expression andt4e1: ents2Label-mention-ngram: and Rb phosphorylationtOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn Gene_or_gene_productt.e2: ents2Label-mention-ngram: downregulate thet-interceding-token ngrams: increases levels oft=e2: trigger-arg-path: downregulate >nsubj >prep_of controllert2e1: ents2Label-mention-ngram: SHARED D1 expressiontinterceding-token ngrams: p27t?e2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controller:Gene_or_gene_productt8e2: args2Role-mention-ngram: downregulate the expressiontVe1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='ltf'] controllertde2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj >prep_of controller:Gene_or_gene_productt:e1: args2Role-mention-ngram: treatment inhibits CONTROLLEDt.interceding-token ngrams: and increases levelste2: trigger: downregulatet*e2: ents2Label-mention-ngram: downregulatet5e2: args2Role-mention-ngram: expression of CONTROLLEDtke1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='ltf'] Gene_or_gene_producttRe1: trigger-arg-path: inhibits:Negative_regulation >nsubj >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] Gene_or_gene_producttve1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controllert!interceding-token ngrams: and p27tOe2: trigger-arg-path: lemmatizedTrigger=downregulate >nsubj >prep_of controllert e2: ents2Label-mention-ngram: Rbt$e2: args2Role-mention-ngram: p27 mayt?e2: trigger-arg-path: downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] controller:Gene_or_gene_productt)interceding-token ngrams: Upregulation oft!interceding-token ngrams: p21 andt0e1: ents2Label-mention-ngram: inhibits SHARED D1t.e2: ents2Label-mention-ngram: may downregulatet1e2: args2Role-mention-ngram: may downregulate thet*interceding-token ngrams: increases levelst:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p27tne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: and Rbt7e1: ents2Label-mention-ngram: treatment inhibits SHAREDt?e2: trigger-arg-path: downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] Gene_or_gene_productte1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='ltf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=downregulate:Negative_regulation >nsubj [lemma='upregulation'] >prep_of [lemma='p21'] Gene_or_gene_producttRe2: trigger-arg-path: downregulate >nsubj >prep_of controller:Gene_or_gene_productt3interceding-token ngrams: expression . UpregulationtGe2: trigger-arg-path: downregulate >nsubj >prep_of Gene_or_gene_producttke1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='ltf'] controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] themet&interceding-token ngrams: CDK2 complextEe2: trigger-arg-path: binds e2: trigger-arg-path: binds:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binds >prep_to [lemma='complex'] >nn [lemma='cycline'] themet#interceding-token ngrams: complex .t.e2: ents2Label-mention-ngram: which then bindstce2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='complex'] >nn [lemma='cycline'] themetGe2: trigger-arg-path: Binding prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_productt/anaphor-basic: args2Role-mention-ngram: bindingtie2: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_productt(interceding-token ngrams: CDK2 complex .toe2: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_productt0CSSPATH: ROOT >xcomp >dobj >rcmod ++ ROOT >nsubjtOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttZe2: trigger-arg-path: binds:Binding >prep_to [lemma='complex'] >nn [lemma='cycline'] themet-e2: args2Role-mention-ngram: which then bindstre2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_productt6e2: trigger-arg-path: binds prep_to [lemma='complex'] >nn [lemma='cycline'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding prep_to [lemma='complex'] >nn [lemma='cycline'] themetanaphor-basic: incoming: prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_productt0anaphor-basic: ents2Label-mention-ngram: bindingt*interceding-token ngrams: and CDK2 complextMe2: trigger-arg-path: binds:Binding prep_to [lemma='complex'] >nn [lemma='cycline'] Gene_or_gene_producttKe2: trigger-arg-path: binds nsubj [lemma='p38'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk'] controllertIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk'] controllert0e2: ents2Label-mention-ngram: residues of SHAREDt6e2: ents2Label-mention-ngram: phosphorylates threoninet?e2: ents2Label-mention-ngram: phosphorylates threonine residuestNe2: trigger-arg-path: phosphorylates >nsubj [lemma='p38'] Gene_or_gene_productt%interceding-token ngrams: treatment .t^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk'] controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk'] controller:Gene_or_gene_productt2interceding-token ngrams: transcriptional activityt0interceding-token ngrams: induction of apoptosistinterceding-token ngrams: p73t#interceding-token ngrams: cisplatintDe2: trigger-arg-path: phosphorylates >nsubj [lemma='p38'] controllert~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38'] controller:Gene_or_gene_productt7interceding-token ngrams: increases p73 transcriptionaltje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38'] controller:Gene_or_gene_productt1interceding-token ngrams: stimulates induction oft#interceding-token ngrams: Similarlytge1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk'] controller:Gene_or_gene_productt&interceding-token ngrams: induction oftSe1: trigger-arg-path: mediated >nsubj [lemma='jnk'] controller:Gene_or_gene_producttme2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: threonine residuest%interceding-token ngrams: Similarly ,t)interceding-token ngrams: apoptosis aftertie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38'] controllertXe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38'] controllert)e2: ents2Label-mention-ngram: residues oft/interceding-token ngrams: treatment . Similarlyt6interceding-token ngrams: transcriptional activity andt.interceding-token ngrams: stimulates inductiontde1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk'] controller:Gene_or_gene_productt%interceding-token ngrams: . SimilarlytYe2: trigger-arg-path: phosphorylates >nsubj [lemma='p38'] controller:Gene_or_gene_productt&interceding-token ngrams: of apoptosist'interceding-token ngrams: . Similarly ,t\e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk'] Gene_or_gene_producttRe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='jnk'] controllert,interceding-token ngrams: of apoptosis aftert2interceding-token ngrams: and stimulates inductiontKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates threoninet_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38'] Gene_or_gene_producttHe1: trigger-arg-path: mediated >nsubj [lemma='jnk'] Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='jnk'] Gene_or_gene_productt)interceding-token ngrams: transcriptionaltSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38'] Gene_or_gene_productt#interceding-token ngrams: treatmentt)interceding-token ngrams: after cisplatint#interceding-token ngrams: inductiontme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='jnk'] Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38'] controller:Gene_or_gene_productt?interceding-tokens-full-span: increases p73 transcriptional activity and stimulates induction of apoptosis after cisplatin treatment . Similarly ,t3interceding-token ngrams: after cisplatin treatmentt(interceding-token ngrams: and stimulatest/interceding-token ngrams: cisplatin treatment .t6interceding-token ngrams: p73 transcriptional activityt-interceding-token ngrams: p73 transcriptionalt-interceding-token ngrams: cisplatin treatmenttIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='p38'] controllert3interceding-token ngrams: apoptosis after cisplatintUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38'] controllert'interceding-token ngrams: increases p73tYe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk'] Gene_or_gene_productt>e1: trigger-arg-path: mediated >nsubj [lemma='jnk'] controllert1interceding-token ngrams: activity and stimulatestse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='jnk'] controllert$interceding-token ngrams: stimulatest3e2: ents2Label-mention-ngram: threonine residues oftVe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn controllert0e2: args2Role-mention-ngram: expression allowingt!e2: args2Role-mention-ngram: genet-e1: args2Role-mention-ngram: increase the DNAtxe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn [lemma='ra'] controllert'interceding-token ngrams: high level oft!e2: args2Role-mention-ngram: moret@e1: trigger-arg-path: increase:Positive_regulation >nsubj Familyt_e2: trigger-arg-path: Positive_activation >dobj [lemma='saf-1'] controlled:Gene_or_gene_producttee2: trigger-arg-path: allowing:Positive_activation nn [lemma='ra'] Familyt4e1: ents2Label-mention-ngram: transcription factor ,t5e2: args2Role-mention-ngram: expression allowing moret1e1: ents2Label-mention-ngram: , a transcriptionalt?e1: ents2Label-mention-ngram: regulator of GENE_OR_GENE_PRODUCTtEe2: trigger-arg-path: Positive_activation nn controller:Familyt$interceding-token ngrams: the breasttce2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='saf-1'] controlled:Gene_or_gene_productt4e1: ents2Label-mention-ngram: transcription functiont$interceding-token ngrams: of SAF-1 /t*e1: ents2Label-mention-ngram: regulator oft"interceding-token ngrams: of SAF-1t+e2: ents2Label-mention-ngram: allowing moret%e2: args2Role-mention-ngram: allowingtTe2: trigger-arg-path: Positive_activation >dobj [lemma='saf-1'] Gene_or_gene_productt7e1: trigger-arg-path: increase >nsubj controller:FamilytNe2: trigger-arg-path: allowing:Positive_activation nn controller:Familyt%interceding-token ngrams: turn , hightXe2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='saf-1'] Gene_or_gene_productt$e1: args2Role-mention-ngram: the DNAtKe1: trigger-arg-path: increase:Positive_regulation >nsubj controller:FamilytNe2: trigger-arg-path: lemmatizedTrigger=allow >dobj [lemma='saf-1'] controlledt-e1: ents2Label-mention-ngram: the DNA bindingtXe1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='ra'] controller:Familyt$interceding-token ngrams: is presentt+interceding-token ngrams: the breast cancert&interceding-token ngrams: , high levelt!interceding-token ngrams: / MAZ ,t)e1: ents2Label-mention-ngram: of SHARED /t/e2: trigger-arg-path: allowing >dobj controlledt>e2: trigger-arg-path: lemmatizedTrigger=allow nn Familyt)e2: ents2Label-mention-ngram: SHARED genet'interceding-token ngrams: breast cancertQe1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='ra'] controllert]e2: trigger-arg-path: allowing:Positive_activation >dobj [lemma='saf-1'] Gene_or_gene_productt/e2: trigger-arg-path: allowing nn Familyt-e2: ents2Label-mention-ngram: gene expressiont(interceding-token ngrams: cancer cells ,tIe2: trigger-arg-path: lemmatizedTrigger=allow nn controller:Familyt?e2: trigger-arg-path: allowing >dobj [lemma='saf-1'] controlledtinterceding-token ngrams: MAZt:e1: ents2Label-mention-ngram: transcriptional regulator oftOe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] controllert#interceding-token ngrams: In turn ,t=e1: trigger-arg-path: increase >nsubj [lemma='ra'] controllert(interceding-token ngrams: level of SAF-1t6e1: ents2Label-mention-ngram: MAZ transcription factort interceding-token ngrams: , thatt5e2: args2Role-mention-ngram: allowing more CONTROLLEDtIe2: trigger-arg-path: allowing >dobj [lemma='saf-1'] Gene_or_gene_productt#interceding-token ngrams: . In turntge2: trigger-arg-path: Positive_activation nn [lemma='ra'] controller:Familyt(interceding-token ngrams: present in thetIe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj controller:Familyte2: trigger: allowingt&e2: ents2Label-mention-ngram: allowingtQe2: trigger-arg-path: allowing nn [lemma='ra'] FamilytMe2: trigger-arg-path: allowing:Positive_activation >dobj Gene_or_gene_productt7e1: ents2Label-mention-ngram: transcription function oft,e2: args2Role-mention-ngram: gene expressiontSe2: trigger-arg-path: allowing:Positive_activation >dobj [lemma='saf-1'] controlledt/e1: ents2Label-mention-ngram: and transcriptiontGe2: trigger-arg-path: allowing:Positive_activation nn controllertVe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] controller:Familyt0e1: ents2Label-mention-ngram: function of SHAREDt)e1: args2Role-mention-ngram: can increaset)interceding-token ngrams: that is presentt,e2: args2Role-mention-ngram: CONTROLLER genet*e1: ents2Label-mention-ngram: SHARED / MAZt>e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj Familyt2e2: ents2Label-mention-ngram: allowing more SHAREDt`e2: trigger-arg-path: Positive_activation nn [lemma='ra'] controllertpe2: trigger-arg-path: allowing:Positive_activation nn [lemma='ra'] controller:Familyt|interceding-tokens-full-span: . In turn , high level of SAF-1 / MAZ , that is present in the breast cancer cells , increasest1e1: ents2Label-mention-ngram: SHARED can increasetRe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn Familyt7e1: ents2Label-mention-ngram: binding and transcriptionte1: ents2Label-mention-ngram: /tke2: trigger-arg-path: lemmatizedTrigger=allow nn [lemma='ra'] controller:Familyt4e1: args2Role-mention-ngram: CONTROLLER can increasetXe2: trigger-arg-path: allowing:Positive_activation >dobj controlled:Gene_or_gene_productt,e1: trigger-arg-path: increase >nsubj Familyt+interceding-token ngrams: cells , increasest!interceding-token ngrams: presentt"e2: ents2Label-mention-ngram: genet_e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] Familyt$interceding-token ngrams: high levelt1e1: ents2Label-mention-ngram: / MAZ transcriptiont"e2: ents2Label-mention-ngram: moret)e1: ents2Label-mention-ngram: function oft]e2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn controller:Familyt!interceding-token ngrams: that ist-e1: ents2Label-mention-ngram: DNA binding andtDe2: trigger-arg-path: allowing >dobj controlled:Gene_or_gene_producttie2: trigger-arg-path: allowing:Positive_activation nn [lemma='ra'] controllert'e1: ents2Label-mention-ngram: regulatort)e1: args2Role-mention-ngram: increase thet\e2: trigger-arg-path: Positive_activation nn [lemma='ra'] Familyt6e2: ents2Label-mention-ngram: gene expression allowingt!e1: ents2Label-mention-ngram: MAZtinterceding-token ngrams: / MAZtKe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] Familyt/e1: ents2Label-mention-ngram: a transcriptionalt]e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controller:Familyt"CSSPATH: ROOT  ++ ROOT >dobj >vmodte2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn [lemma='ra'] controller:FamilytMe1: trigger-arg-path: increase:Positive_regulation >nsubj [lemma='ra'] Familyt9e2: trigger-arg-path: allowing >dobj Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=allow nn controllert:e2: trigger-arg-path: allowing nn controller:FamilytTe2: trigger-arg-path: allowing >dobj [lemma='saf-1'] controlled:Gene_or_gene_productt#interceding-token ngrams: , that istde2: trigger-arg-path: lemmatizedTrigger=allow nn [lemma='ra'] controllertle2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='saf-1'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >dobj [lemma='saf-1'] controlledt`e2: trigger-arg-path: lemmatizedTrigger=allow nn [lemma='ra'] Familyt9e1: ents2Label-mention-ngram: a transcriptional regulatort7e1: ents2Label-mention-ngram: transcriptional regulatort interceding-token ngrams: turn ,tce1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] controllert8e1: ents2Label-mention-ngram: and transcription functiontUe2: trigger-arg-path: allowing nn [lemma='ra'] controllert/e1: ents2Label-mention-ngram: MAZ transcriptiont1e2: ents2Label-mention-ngram: expression allowingt'interceding-token ngrams: is present intje1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] controller:Familyt.e1: ents2Label-mention-ngram: can increase thet'interceding-token ngrams: in the breasttinterceding-token ngrams: SAF-1t)e2: ents2Label-mention-ngram: more SHAREDt interceding-token ngrams: , hight%interceding-token ngrams: , increasest5e2: args2Role-mention-ngram: gene expression allowingt7e2: args2Role-mention-ngram: CONTROLLER gene expressiont$interceding-token ngrams: MAZ , thatt%interceding-token ngrams: SAF-1 / MAZt9e1: trigger-arg-path: increase >nsubj [lemma='ra'] Familyt.e1: ents2Label-mention-ngram: increase the DNAtinterceding-token ngrams: MAZ ,the2: trigger-arg-path: allowing:Positive_activation >dobj [lemma='saf-1'] controlled:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='saf-1'] controlledtCe2: trigger-arg-path: allowing:Positive_activation >dobj controlledt\e2: trigger-arg-path: allowing nn [lemma='ra'] controller:Familyt!interceding-token ngrams: SAF-1 /t/e1: args2Role-mention-ngram: the DNA CONTROLLEDtCe2: trigger-arg-path: allowing:Positive_activation nn Familyt!interceding-token ngrams: In turnt*e1: ents2Label-mention-ngram: can increasetDe1: trigger-arg-path: increase >nsubj [lemma='ra'] controller:Familyt-interceding-token ngrams: breast cancer cellst)e1: ents2Label-mention-ngram: DNA bindingt3e2: trigger-arg-path: allowing nn controllert,e2: args2Role-mention-ngram: more CONTROLLEDtRe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj Familyt$interceding-token ngrams: present intte2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation nn [lemma='ra'] Familyt4e2: ents2Label-mention-ngram: SHARED gene expressiont*e2: args2Role-mention-ngram: allowing moretwe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_activation >dobj [lemma='saf-1'] controlled:Gene_or_gene_productt6e2: ents2Label-mention-ngram: expression allowing moret(e1: ents2Label-mention-ngram: factor , at#e1: ents2Label-mention-ngram: / MAZt-e1: args2Role-mention-ngram: can increase thet*e1: ents2Label-mention-ngram: increase thet>e2: trigger-arg-path: Positive_activation nn controllert&e1: ents2Label-mention-ngram: SHARED /t'interceding-token ngrams: determined bytbe1: trigger-arg-path: lemmatizedTrigger=binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] themetye2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: HBS 7t"e1: args2Role-mention-ngram: HBS 7t6e1: trigger-arg-path: binding >conj_and >prep_to themete1: ents2Label-mention-ngram: 3tbe2: trigger-arg-path: bound >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] Gene_or_gene_productt&interceding-token ngrams: fluorescencetHe1: trigger-arg-path: Binding >prep_of [lemma='hb'] Gene_or_gene_productt3interceding-token ngrams: using fluorescein labeledt9interceding-token ngrams: fluorescence polarization assayt3interceding-token ngrams: fluorescence polarizationt5e2: trigger-arg-path: Binding >nsubj >prep_with themethe2: trigger-arg-path: bound >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] theme:Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] themet_e1: trigger-arg-path: binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] theme:Familyt2interceding-token ngrams: polarization assay usingt!e1: ents2Label-mention-ngram: HBSt4interceding-token ngrams: determined by fluorescencetbe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hb'] Gene_or_gene_producttPe2: trigger-arg-path: bound:Binding >nsubj >prep_with theme:Gene_or_gene_productt$interceding-token ngrams: determinedtle2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] themet{e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] Gene_or_gene_productt9e1: trigger-arg-path: binding >prep_of [lemma='hb'] themetje2: trigger-arg-path: bound:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=binding >conj_and >prep_to themet!interceding-token ngrams: labeledtxinterceding-tokens-full-span: were determined by fluorescence polarization assay using fluorescein labeled peptides withtje2: trigger-arg-path: Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] theme:Gene_or_gene_productte1: args2Role-mention-ngram: 3t)interceding-token ngrams: by fluorescencetde2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] themet'e1: args2Role-mention-ngram: of THEME 3t=e1: trigger-arg-path: Binding >conj_and >prep_to theme:Familyt[e2: trigger-arg-path: bound:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] themetDe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_with themetPe1: trigger-arg-path: Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] themetSe2: trigger-arg-path: bound >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] themet/interceding-token ngrams: labeled peptides witht9e1: trigger-arg-path: Binding >prep_of [lemma='hb'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and >prep_to themetBe2: trigger-arg-path: bound >nsubj >prep_with Gene_or_gene_productt7e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT 3t)e1: ents2Label-mention-ngram: 7 to SHAREDtQe1: trigger-arg-path: binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] Familyt&interceding-token ngrams: polarizationt'interceding-token ngrams: peptides withtJshortest-path: agent >vmod >dobj >vmod >ccomp >nsubj >prep_witht"e1: args2Role-mention-ngram: 3 andt#e1: ents2Label-mention-ngram: 3 andt6interceding-token ngrams: fluorescein labeled peptidest?shortest-path: agent [lemma='assay'] >vmod [lemma='use'] >dobj [lemma='fluorescein'] >vmod [lemma='label'] >ccomp [lemma='bind'] >nsubj [lemma='peptide'] >prep_with [lemma='GDP']tSe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hb'] themetpe2: trigger-arg-path: bound:Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 3 andt"e1: ents2Label-mention-ngram: 7 tot=e1: ents2Label-mention-ngram: binding of GENE_OR_GENE_PRODUCTt7e1: trigger-arg-path: Binding >conj_and >prep_to Familyt[e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_with Gene_or_gene_productt,interceding-token ngrams: polarization assayt&e1: args2Role-mention-ngram: 3 and HBStNe1: trigger-arg-path: binding >prep_of [lemma='hb'] theme:Gene_or_gene_producttEe1: trigger-arg-path: binding:Binding >conj_and >prep_to theme:Familyt3e2: trigger-arg-path: bound >nsubj >prep_with themet;e2: trigger-arg-path: bound:Binding >nsubj >prep_with themet%e1: ents2Label-mention-ngram: and HBSt)interceding-token ngrams: were determinedt%interceding-token ngrams: assay usingte1: ents2Label-mention-ngram: 7t$e1: args2Role-mention-ngram: and HBStQe1: trigger-arg-path: Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] Familytinterceding-token ngrams: usingtPe1: trigger-arg-path: binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] themetWe1: trigger-arg-path: Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] theme:FamilytYe1: trigger-arg-path: binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] Familytqe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] theme:Familytinterceding-token ngrams: weretftrigger-to-trigger-path: e1:binding:Binding agent >vmod >dobj >vmod >ccomp e2:bound:BindingtUe2: trigger-arg-path: Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] themet&e1: args2Role-mention-ngram: and HBS 7t>e1: trigger-arg-path: binding:Binding >conj_and >prep_to themet$e1: args2Role-mention-ngram: THEME 3t+interceding-token ngrams: using fluoresceint?e1: trigger-arg-path: binding:Binding >conj_and >prep_to Familyt%e1: args2Role-mention-ngram: HBS 7 tot&e1: ents2Label-mention-ngram: HBS 7 tot%interceding-token ngrams: fluoresceint7e1: trigger-arg-path: binding >conj_and >prep_to FamilytJe2: trigger-arg-path: Binding >nsubj >prep_with theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_with Gene_or_gene_productt6interceding-token ngrams: by fluorescence polarizationtJe2: trigger-arg-path: bound:Binding >nsubj >prep_with Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] theme:Familytje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] themet e1: args2Role-mention-ngram: HBStHe1: trigger-arg-path: binding >prep_of [lemma='hb'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hb'] Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME 3 andt6e1: trigger-arg-path: Binding >conj_and >prep_to themetPe1: trigger-arg-path: binding:Binding >prep_of [lemma='hb'] Gene_or_gene_productt?trigger-to-trigger-path: e1:binding:Binding agent [lemma='assay'] >vmod [lemma='use'] >dobj [lemma='fluorescein'] >vmod [lemma='label'] >ccomp [lemma='bind'] e2:bound:BindingtOe1: trigger-arg-path: lemmatizedTrigger=binding >conj_and >prep_to theme:Familyt1interceding-token ngrams: assay using fluoresceint=e1: trigger-arg-path: binding >conj_and >prep_to theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_with themethe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hb'] theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and >prep_to theme:Familyt*interceding-token ngrams: labeled peptidest'e1: ents2Label-mention-ngram: 3 and HBSt-interceding-token ngrams: fluorescein labeledtde2: trigger-arg-path: Binding >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >prep_of [lemma='hb'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: 7 to THEMEt4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 3t,interceding-token ngrams: were determined byt`e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hb'] theme:Gene_or_gene_producttWe1: trigger-arg-path: binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] theme:Familyte1: args2Role-mention-ngram: 7t!e1: args2Role-mention-ngram: 7 totIe1: trigger-arg-path: lemmatizedTrigger=binding >conj_and >prep_to FamilytQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and >prep_to Familytse2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='peptide'] >prep_with [lemma='GDP'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_with theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding >nsubj >prep_with Gene_or_gene_producttVe1: trigger-arg-path: binding:Binding >prep_of [lemma='hb'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] FamilytHe2: trigger-arg-path: bound >nsubj >prep_with theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hb'] themetke1: trigger-arg-path: lemmatizedTrigger=binding:Binding >conj_and [lemma='hb'] >prep_to [lemma='ra'] Familyt'e1: ents2Label-mention-ngram: and HBS 7tae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_with theme:Gene_or_gene_producttAe1: trigger-arg-path: binding:Binding >prep_of [lemma='hb'] themet*e1: ents2Label-mention-ngram: FAMILY formst,e1: ents2Label-mention-ngram: FAMILY forms at?e1: trigger-arg-path: forms a complex prep_with [lemma='ezh2'] Gene_or_gene_productt+interceding-token ngrams: expression in NPCt interceding-token ngrams: ( HDACtnsubj [lemma='snail'] Familyt"interceding-token ngrams: suppresst interceding-token ngrams: in NPCtie1: trigger-arg-path: Binding prep_with [lemma='ezh2'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='ezh2'] Gene_or_gene_producttinterceding-token ngrams: NPCtye1: trigger-arg-path: forms a complex:Binding prep_with [lemma='ezh2'] themetUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='c-Myc'] themet interceding-token ngrams: HDAC )t-interceding-token ngrams: E-cadherin promotertoe1: trigger-arg-path: forms a complex nsubj [lemma='snail'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='ezh2'] themetde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='c-Myc'] Gene_or_gene_productt"interceding-token ngrams: in NPC .t/interceding-token ngrams: histone deacetylase (tge1: trigger-arg-path: Binding nsubj [lemma='snail'] Familyt%interceding-token ngrams: recruits itt?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='ezh2'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='c-Myc'] Gene_or_gene_productt(interceding-token ngrams: recruits it totOe1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj Familyt'interceding-token ngrams: to E-cadherintnsubj [lemma='c-Myc'] themet?interceding-tokens-full-span: via histone deacetylase ( HDAC ) 1 and 2 and recruits it to E-cadherin promoter to suppress E-cadherin expression in NPC .t0interceding-token ngrams: to suppress E-cadherint>e1: trigger-arg-path: forms a complex nsubj Familyt$interceding-token ngrams: E-cadherint(interceding-token ngrams: 2 and recruitstinterceding-token ngrams: ) 1t/interceding-token ngrams: E-cadherin expressiontFe1: trigger-arg-path: forms a complex:Binding nsubj Familyt.interceding-token ngrams: promoter to suppresst1interceding-token ngrams: via histone deacetylasetue1: trigger-arg-path: forms a complex nsubj [lemma='snail'] theme:Familyt8interceding-token ngrams: suppress E-cadherin expressiont0interceding-token ngrams: E-cadherin promoter tot?e1: trigger-arg-path: forms a complex prep_with [lemma='ezh2'] theme:Gene_or_gene_productt6e1: trigger-arg-path: Binding nsubj FamilytWe1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj Familyt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='ezh2'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='ezh2'] Gene_or_gene_producttinterceding-token ngrams: 1 andtinterceding-token ngrams: NPC .tDe1: trigger-arg-path: forms a complex nsubj theme:FamilytMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='c-Myc'] themet~e1: trigger-arg-path: Binding prep_with [lemma='ezh2'] theme:Gene_or_gene_productt0interceding-token ngrams: to E-cadherin promotertQe2: trigger-arg-path: interacts >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='snail'] theme:FamilytDe2: trigger-arg-path: interacts:Binding >nsubj [lemma='c-Myc'] themet!interceding-token ngrams: ) 1 andtinterceding-token ngrams: 2 andte1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='snail'] themetme1: trigger-arg-path: Binding nsubj [lemma='snail'] theme:Familytxe1: trigger-arg-path: Binding prep_with [lemma='ezh2'] Gene_or_gene_productt}e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='snail'] theme:Familyt!interceding-token ngrams: 1 and 2t"interceding-token ngrams: ( HDAC )t2interceding-token ngrams: E-cadherin expression int]e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj theme:Familyt?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='snail'] themetAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interacts withtbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='c-Myc'] theme:Gene_or_gene_producttve1: trigger-arg-path: forms a complex:Binding nsubj [lemma='snail'] themet%interceding-token ngrams: promoter tot?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='snail'] Familyt)interceding-token ngrams: and recruits ittne1: trigger-arg-path: forms a complex nsubj [lemma='snail'] themetqe1: trigger-arg-path: forms a complex prep_with [lemma='ezh2'] themet"interceding-token ngrams: HDAC ) 1t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='ezh2'] theme:Gene_or_gene_productt,interceding-token ngrams: deacetylase ( HDACtinterceding-token ngrams: and 2t*interceding-token ngrams: it to E-cadherint?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='snail'] Familytfe1: trigger-arg-path: Binding nsubj [lemma='snail'] themetinterceding-token ngrams: it totje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='c-Myc'] theme:Gene_or_gene_producttLe1: trigger-arg-path: forms a complex:Binding nsubj theme:Familyt-interceding-token ngrams: suppress E-cadherintSe2: trigger-arg-path: interacts:Binding >nsubj [lemma='c-Myc'] Gene_or_gene_productt%interceding-token ngrams: via histonet%interceding-token ngrams: to suppresstYe2: trigger-arg-path: interacts:Binding >nsubj [lemma='c-Myc'] theme:Gene_or_gene_productt#interceding-token ngrams: and 2 andtKe2: trigger-arg-path: interacts >nsubj [lemma='c-Myc'] Gene_or_gene_productt'interceding-token ngrams: deacetylase (tnsubj theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='snail'] theme:FamilytUe1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='ezh2'] theme:Gene_or_gene_producttinterceding-token ngrams: HDACt*interceding-token ngrams: and consequentlyt.interceding-token ngrams: the catalytic actiont&interceding-token ngrams: of the valuet#interceding-token ngrams: restrictst#interceding-token ngrams: and Cdc25t5interceding-tokens-full-span: interaction and consequently restricts the catalytic action of Cdc25 on wt Ras . Furthermore , given the similarity of the value of the K D of the oxidant for the wt Ras and Cdc25 complex and that of the app K I of the oxidant for the ternary complex , the perturbation of the wtt interceding-token ngrams: actiont"interceding-token ngrams: of Cdc25tinterceding-token ngrams: valuetinterceding-token ngrams: the Kt$interceding-token ngrams: similarityt"interceding-token ngrams: wt Ras .t+interceding-token ngrams: Cdc25 complex andt'interceding-token ngrams: Ras and Cdc25t interceding-token ngrams: K D oft&interceding-token ngrams: the value oft"interceding-token ngrams: Cdc25 ontinterceding-token ngrams: K Dt*interceding-token ngrams: catalytic actiont%interceding-token ngrams: complex andt$interceding-token ngrams: the wt Rast%interceding-token ngrams: , given thet6interceding-token ngrams: interaction and consequentlyt;CSSPATH: ROOT >ccomp >prep_with >nn ++ ROOT >nsubj >prep_oft#interceding-token ngrams: catalytict'interceding-token ngrams: Cdc25 complext#interceding-token ngrams: on wt Rast)interceding-token ngrams: action of Cdc25t4interceding-token ngrams: and consequently restrictst.interceding-token ngrams: given the similarityt%interceding-token ngrams: Furthermoret%interceding-token ngrams: of Cdc25 ont#interceding-token ngrams: given thet(interceding-token ngrams: the similarityt'interceding-token ngrams: . Furthermoret interceding-token ngrams: wt Rastinterceding-token ngrams: givent+interceding-token ngrams: Ras . Furthermoret)interceding-token ngrams: . Furthermore ,t#interceding-token ngrams: the valuet1interceding-token ngrams: restricts the catalytict"interceding-token ngrams: value oft-interceding-token ngrams: Furthermore , giventinterceding-token ngrams: on wtt*interceding-token ngrams: complex and thatt"interceding-token ngrams: of the Kt#interceding-token ngrams: action oft%interceding-token ngrams: Cdc25 on wttinterceding-token ngrams: D oft'interceding-token ngrams: Furthermore ,tinterceding-token ngrams: Cdc25t'interceding-token ngrams: restricts thet-interceding-token ngrams: catalytic action oft&interceding-token ngrams: value of thet4interceding-token ngrams: consequently restricts thet)interceding-token ngrams: interaction andt'interceding-token ngrams: the catalytict+interceding-token ngrams: and Cdc25 complext0interceding-token ngrams: consequently restrictst+interceding-token ngrams: the similarity oft$interceding-token ngrams: for the wtt+interceding-token ngrams: similarity of thet!interceding-token ngrams: Ras andt"interceding-token ngrams: D of thet'interceding-token ngrams: similarity oft$interceding-token ngrams: wt Ras andt!interceding-token ngrams: the K Dt!interceding-token ngrams: , giventke2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='raf-1'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of Gene_or_gene_producttNe2: trigger-arg-path: activation:Positive_activation prep_by Familyt*interceding-token ngrams: is important fort7e1: trigger-arg-path: Binding >nsubj [lemma='pa'] themet0e1: ents2Label-mention-ngram: can associate witht/e1: args2Role-mention-ngram: can associate withtze2: trigger-arg-path: activation:Positive_activation prep_by [lemma='ra'] controller:Familyt'interceding-token ngrams: important fort_e2: trigger-arg-path: activation prep_by [lemma='ra'] controllertWe1: trigger-arg-path: associate:Binding >prep_with [lemma='raf-1'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='raf-1'] controlledtbe2: trigger-arg-path: Positive_activation >prep_of [lemma='raf-1'] controlled:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='raf-1'] controlled:Gene_or_gene_producttoe2: trigger-arg-path: activation:Positive_activation prep_by [lemma='ra'] Familyt8e1: trigger-arg-path: associate:Binding >prep_with themet&interceding-token ngrams: target it totNe1: trigger-arg-path: associate >nsubj [lemma='pa'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by [lemma='ra'] controller:Familyt2interceding-token ngrams: recruitment is importanttse2: trigger-arg-path: activation:Positive_activation prep_by [lemma='ra'] controllertSe1: trigger-arg-path: Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='raf-1'] controlledtAe1: trigger-arg-path: associate:Binding >nsubj [lemma='pa'] themetGe1: trigger-arg-path: associate:Binding >prep_with Gene_or_gene_producttGe2: trigger-arg-path: Positive_activation prep_by controllertAe1: trigger-arg-path: associate >nsubj theme:Gene_or_gene_producttNe2: trigger-arg-path: activation >prep_of [lemma='raf-1'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='raf-1'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='raf-1'] Gene_or_gene_productt,interceding-token ngrams: for the subsequenttIe1: trigger-arg-path: associate:Binding >nsubj theme:Gene_or_gene_productt)interceding-token ngrams: membrane . Thist(interceding-token ngrams: the membrane .txe2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='ra'] controller:Familytbe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='pa'] Gene_or_gene_producttHe1: trigger-arg-path: associate:Binding >prep_with [lemma='raf-1'] themetZe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='raf-1'] themethe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='pa'] theme:Gene_or_gene_producttde2: trigger-arg-path: Positive_activation prep_by [lemma='ra'] Familyt.interceding-token ngrams: This Ras independentt+e1: ents2Label-mention-ngram: can associatetRe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='raf-1'] themet4e1: trigger-arg-path: associate:Binding >nsubj themet&interceding-token ngrams: the membranethe2: trigger-arg-path: Positive_activation prep_by [lemma='ra'] controllert$interceding-token ngrams: and targettme2: trigger-arg-path: activation:Positive_activation >prep_of [lemma='raf-1'] controlled:Gene_or_gene_productt;e1: trigger-arg-path: associate >nsubj Gene_or_gene_producttHe2: trigger-arg-path: activation:Positive_activation >prep_of controlledt:e2: trigger-arg-path: activation prep_by Familyt#interceding-token ngrams: target itt1interceding-token ngrams: independent recruitmenttde2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of Gene_or_gene_productt&interceding-token ngrams: is importantt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by [lemma='ra'] controllertYe2: trigger-arg-path: activation:Positive_activation prep_by controller:Familyt@e1: trigger-arg-path: associate >prep_with [lemma='raf-1'] themetMe2: trigger-arg-path: Positive_activation >prep_of [lemma='raf-1'] controlledt interceding-token ngrams: targett"interceding-token ngrams: This RastNe2: trigger-arg-path: Positive_activation prep_by controller:FamilytFe1: trigger-arg-path: Binding >nsubj [lemma='pa'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by controllert(interceding-token ngrams: the subsequenttae1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='raf-1'] Gene_or_gene_producttVe1: trigger-arg-path: associate:Binding >nsubj [lemma='pa'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of controlledtOe1: trigger-arg-path: associate >prep_with [lemma='raf-1'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=activation >prep_of controlled:Gene_or_gene_productt)interceding-token ngrams: to the membranetUe1: trigger-arg-path: associate >prep_with [lemma='raf-1'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='pa'] themetMe1: trigger-arg-path: Binding >prep_with [lemma='raf-1'] Gene_or_gene_producttYe2: trigger-arg-path: activation >prep_of [lemma='raf-1'] controlled:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of controlled:Gene_or_gene_productt)interceding-token ngrams: Ras independenttDe2: trigger-arg-path: activation >prep_of [lemma='raf-1'] controlledtZe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='pa'] Gene_or_gene_producttMe1: trigger-arg-path: associate:Binding >prep_with theme:Gene_or_gene_productt>e2: trigger-arg-path: activation >prep_of Gene_or_gene_producttHe1: trigger-arg-path: associate >nsubj [lemma='pa'] Gene_or_gene_productt(interceding-token ngrams: recruitment ist`e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='pa'] theme:Gene_or_gene_producttLe1: trigger-arg-path: Binding >nsubj [lemma='pa'] theme:Gene_or_gene_producttoe2: trigger-arg-path: Positive_activation prep_by [lemma='ra'] controller:Familytie1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='raf-1'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: associate with SHAREDt~interceding-tokens-full-span: and target it to the membrane . This Ras independent recruitment is important for the subsequenttCe2: trigger-arg-path: Positive_activation prep_by Familyte1: trigger: associatetme2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='ra'] FamilytIe2: trigger-arg-path: activation >prep_of controlled:Gene_or_gene_productt CSSPATH: ROOT  ++ ROOT >prep_fort5interceding-token ngrams: Ras independent recruitmentt+interceding-token ngrams: important for thetbe2: trigger-arg-path: activation:Positive_activation >prep_of [lemma='raf-1'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: can associatet>e2: trigger-arg-path: activation prep_by controllertRe2: trigger-arg-path: activation:Positive_activation prep_by controllert@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can associatet]e1: trigger-arg-path: associate:Binding >prep_with [lemma='raf-1'] theme:Gene_or_gene_productt9e1: trigger-arg-path: associate >nsubj [lemma='pa'] themet0e1: args2Role-mention-ngram: THEME can associatet0e1: trigger-arg-path: associate >prep_with themet,e1: trigger-arg-path: associate >nsubj themet>e1: trigger-arg-path: Binding >prep_with [lemma='raf-1'] themetRe2: trigger-arg-path: activation:Positive_activation >prep_of Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=activation prep_by Familyt`e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by FamilytXe2: trigger-arg-path: activation:Positive_activation >prep_of [lemma='raf-1'] controlledt#interceding-token ngrams: it to thet$interceding-token ngrams: membrane .tke2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by controller:Familyt`e2: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='raf-1'] Gene_or_gene_productt$interceding-token ngrams: . This RastEe2: trigger-arg-path: activation prep_by controller:FamilytSe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='pa'] themetCe1: trigger-arg-path: associate:Binding >nsubj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation prep_by [lemma='ra'] FamilytWe2: trigger-arg-path: lemmatizedTrigger=activation prep_by controller:Familyt1e1: args2Role-mention-ngram: associate with THEMEtWe2: trigger-arg-path: Positive_activation >prep_of [lemma='raf-1'] Gene_or_gene_productt?e1: trigger-arg-path: associate >prep_with Gene_or_gene_producttfe2: trigger-arg-path: activation prep_by [lemma='ra'] controller:FamilytEe1: trigger-arg-path: associate >prep_with theme:Gene_or_gene_productt4interceding-token ngrams: independent recruitment istqe2: trigger-arg-path: lemmatizedTrigger=activation prep_by [lemma='ra'] controllert[e2: trigger-arg-path: activation prep_by [lemma='ra'] Familyt'interceding-token ngrams: and target ittPe2: trigger-arg-path: lemmatizedTrigger=activation prep_by controllertPe1: trigger-arg-path: associate:Binding >nsubj [lemma='pa'] Gene_or_gene_productt]e2: trigger-arg-path: activation:Positive_activation >prep_of controlled:Gene_or_gene_productt-e1: ents2Label-mention-ngram: that miR-378-5pt+e2: args2Role-mention-ngram: was the targett.e1: args2Role-mention-ngram: BRAF and inhibitstve1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='result'] controller:Simple_chemicalt+e2: ents2Label-mention-ngram: the target oftme1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >prep_of [lemma='braf'] controlledt*e1: args2Role-mention-ngram: bind directlyt@e2: trigger-arg-path: target >prep_of theme:Gene_or_gene_productt$e2: args2Role-mention-ngram: was thet)e2: trigger-arg-path: target >nsubj themet;e2: trigger-arg-path: lemmatizedTrigger=target >nsubj themet]e2: trigger-arg-path: target:Binding >prep_of [lemma='mir-378-5p'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Negative_activation >nsubj controller:Simple_chemicaltze1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] Gene_or_gene_productt&CSSPATH: ROOT >conj_and ++ ROOT >ccomptUe2: trigger-arg-path: target >prep_of [lemma='mir-378-5p'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: can bind directlytTe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of Gene_or_gene_productt&e1: args2Role-mention-ngram: indicatestee1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='result'] controller:Simple_chemicaltge1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlledt@e2: trigger-arg-path: target >prep_of [lemma='mir-378-5p'] themet0e1: args2Role-mention-ngram: that miR-378-5p cantRe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj Gene_or_gene_productt|e1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlled:Gene_or_gene_productt4e1: args2Role-mention-ngram: inhibits the expressiont?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlled:Gene_or_gene_productt$e1: args2Role-mention-ngram: to BRAFt7e1: ents2Label-mention-ngram: indicates that miR-378-5pt+e1: args2Role-mention-ngram: the expressiont:e2: trigger-arg-path: target >prep_of Gene_or_gene_productt-e1: args2Role-mention-ngram: bind directly totLe1: trigger-arg-path: Negative_activation >nsubj [lemma='result'] controllert=e2: trigger-arg-path: lemmatizedTrigger=target >prep_of themetUe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='result'] controllertZe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj Simple_chemicalt#e2: args2Role-mention-ngram: targett?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlledt+e1: ents2Label-mention-ngram: expression oft?e1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlled:Gene_or_gene_productt+e1: args2Role-mention-ngram: indicates thattZe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='result'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >prep_of [lemma='braf'] controlled:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of controlled:Gene_or_gene_producttVe2: trigger-arg-path: Binding >prep_of [lemma='mir-378-5p'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: CONTROLLER indicates thattqe1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: miR-378-5p can bindtQe1: trigger-arg-path: inhibits >nsubj [lemma='result'] controller:Simple_chemicalt)e1: ents2Label-mention-ngram: to BRAF andtke1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='result'] Simple_chemicaltUe2: trigger-arg-path: target:Binding >nsubj [lemma='braf'] theme:Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj themet"e1: ents2Label-mention-ngram: BRAFt_e2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='braf'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: miR-378-5p cant%e1: ents2Label-mention-ngram: to BRAFt>e2: trigger-arg-path: target >nsubj theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='result'] controllert1e1: args2Role-mention-ngram: CONTROLLER indicatest'e1: ents2Label-mention-ngram: indicatest.e1: args2Role-mention-ngram: the expression oftWe2: trigger-arg-path: target:Binding >prep_of [lemma='mir-378-5p'] Gene_or_gene_productt'e1: args2Role-mention-ngram: miR-378-5ptBe2: trigger-arg-path: target:Binding >prep_of Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_of [lemma='mir-378-5p'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt+e2: trigger-arg-path: target >prep_of themet3e2: trigger-arg-path: target:Binding >prep_of themetMe1: trigger-arg-path: inhibits >dobj >prep_of controlled:Gene_or_gene_producttFe1: trigger-arg-path: inhibits >nsubj [lemma='result'] Simple_chemicaltRe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='braf'] themet*e2: args2Role-mention-ngram: THEME was thet(e1: ents2Label-mention-ngram: miR-378-5pt\e1: trigger-arg-path: inhibits >dobj [lemma='expression'] >prep_of [lemma='braf'] controlledt/e1: ents2Label-mention-ngram: BRAF and inhibitst,e2: ents2Label-mention-ngram: SHARED was thetfe1: trigger-arg-path: inhibits >dobj [lemma='expression'] >prep_of [lemma='braf'] Gene_or_gene_productt,e2: args2Role-mention-ngram: target of THEMEtIe1: trigger-arg-path: inhibits:Negative_activation >nsubj Simple_chemicaltpe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] controlledt%e1: args2Role-mention-ngram: BRAF andtGe2: trigger-arg-path: target >nsubj [lemma='braf'] Gene_or_gene_producttHe2: trigger-arg-path: Binding >nsubj [lemma='braf'] Gene_or_gene_productt'interceding-tokens-full-span: . Knowingt(e1: args2Role-mention-ngram: to BRAF andtqe1: trigger-arg-path: inhibits >dobj [lemma='expression'] >prep_of [lemma='braf'] controlled:Gene_or_gene_productt@e2: trigger-arg-path: target:Binding >nsubj Gene_or_gene_producttAe1: trigger-arg-path: inhibits >nsubj [lemma='result'] controllertLe1: trigger-arg-path: inhibits:Negative_activation >dobj >prep_of controlledtae2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mir-378-5p'] Gene_or_gene_producttOe2: trigger-arg-path: target >prep_of [lemma='mir-378-5p'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: the expressiontnsubj theme:Gene_or_gene_productt!interceding-token ngrams: Knowingtge2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mir-378-5p'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: indicates that miR-378-5pt0e1: args2Role-mention-ngram: miR-378-5p can bindt5e1: args2Role-mention-ngram: expression of CONTROLLEDt2e1: ents2Label-mention-ngram: expression of SHAREDtZe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mir-378-5p'] themetJe2: trigger-arg-path: lemmatizedTrigger=target >nsubj Gene_or_gene_producttHe2: trigger-arg-path: target:Binding >prep_of theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=target >prep_of Gene_or_gene_producttnsubj [lemma='braf'] themet7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL indicatest?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='braf'] Gene_or_gene_productt&e2: args2Role-mention-ngram: target oftoe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mir-378-5p'] theme:Gene_or_gene_productt8e1: trigger-arg-path: inhibits >dobj >prep_of controlledtJe2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='braf'] themet'e2: ents2Label-mention-ngram: target oft.e1: args2Role-mention-ngram: can bind directlytwe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >prep_of [lemma='braf'] Gene_or_gene_producttHe2: trigger-arg-path: target:Binding >prep_of [lemma='mir-378-5p'] themet*e1: args2Role-mention-ngram: expression oft%e2: ents2Label-mention-ngram: was thetEe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of themetQe1: trigger-arg-path: Negative_activation >nsubj [lemma='result'] Simple_chemicalte2: trigger: targett&e1: ents2Label-mention-ngram: BRAF andt,e1: args2Role-mention-ngram: that miR-378-5ptRe2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mir-378-5p'] themet@e1: trigger-arg-path: Negative_activation >nsubj Simple_chemicaltZe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='braf'] themet.e1: ents2Label-mention-ngram: directly to BRAFtYe2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='braf'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='result'] controllert'e2: args2Role-mention-ngram: the targettWe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='result'] Simple_chemicalt+e1: args2Role-mention-ngram: miR-378-5p cantSe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of Gene_or_gene_producttTe1: trigger-arg-path: inhibits:Negative_activation >nsubj controller:Simple_chemicalt8e2: trigger-arg-path: target >nsubj Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='braf'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: indicates thatt\e1: trigger-arg-path: Negative_activation >nsubj [lemma='result'] controller:Simple_chemicaltNe2: trigger-arg-path: Binding >nsubj [lemma='braf'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: BRAFtVe1: trigger-arg-path: inhibits:Negative_activation >dobj >prep_of Gene_or_gene_producttAe2: trigger-arg-path: Binding >prep_of [lemma='mir-378-5p'] themetge1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >prep_of Gene_or_gene_productt,e2: ents2Label-mention-ngram: was the targett]e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >prep_of controlledt8e2: trigger-arg-path: target >nsubj [lemma='braf'] themet1e1: ents2Label-mention-ngram: that miR-378-5p cant#interceding-token ngrams: . Knowingt*e2: args2Role-mention-ngram: the target oft5e1: ents2Label-mention-ngram: inhibits the expressiont/e1: ents2Label-mention-ngram: the expression oftRe2: trigger-arg-path: lemmatizedTrigger=target >prep_of theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: bind directly totOe2: trigger-arg-path: target:Binding >nsubj [lemma='braf'] Gene_or_gene_productt1e2: trigger-arg-path: target:Binding >nsubj themetFe2: trigger-arg-path: target:Binding >nsubj theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: the targettae2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='braf'] Gene_or_gene_producttBe1: trigger-arg-path: inhibits >dobj >prep_of Gene_or_gene_producttMe2: trigger-arg-path: target >nsubj [lemma='braf'] theme:Gene_or_gene_producttae1: trigger-arg-path: inhibits:Negative_activation >dobj >prep_of controlled:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:Simple_chemicalt$e2: ents2Label-mention-ngram: targett-e1: args2Role-mention-ngram: directly to BRAFtbe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='result'] controller:Simple_chemicaltie2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mir-378-5p'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kc2beta'] themetCe2: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] themetinterceding-token ngrams: Btve2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt9interceding-tokens-full-span: throughout the cell . ( B )t9CSSPATH: ROOT >xcomp >dobj >prep_of ++ ROOT >rcmod >nsubjtpe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_producttVe2: trigger-arg-path: interaction >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt^e2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt(interceding-token ngrams: throughout thet$interceding-token ngrams: the cell .tae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='pi3kc2beta'] themetOe2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kc2beta'] themetXe2: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt\e2: trigger-arg-path: interaction >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt interceding-token ngrams: cell .t-interceding-token ngrams: throughout the celltinterceding-token ngrams: B )tde2: trigger-arg-path: interaction:Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt"interceding-token ngrams: cell . (tne2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_producttinterceding-token ngrams: . (the2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='pi3kc2beta'] Gene_or_gene_producttGe2: trigger-arg-path: interaction >prep_with [lemma='pi3kc2beta'] themetinterceding-token ngrams: ( B )tinterceding-token ngrams: . ( BtRe2: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_producttinterceding-token ngrams: ( Bt$interceding-token ngrams: throughoutt5e1: ents2Label-mention-ngram: late-endosomal residenttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to theme:Generic_entitytMe1: trigger-arg-path: Binding >prep_to [lemma='protein'] theme:Generic_entitytde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] theme:Generic_entityt0e1: ents2Label-mention-ngram: the late-endosomalt"interceding-token ngrams: the MP-1t\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p14'] theme:Gene_or_gene_productt$interceding-token ngrams: p18 . LosstDe2: trigger-arg-path: complex >nn [lemma='p14'] Gene_or_gene_productt5e1: trigger-arg-path: binding >prep_to Generic_entityt=e1: trigger-arg-path: binding:Binding >prep_to Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] themetde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p14'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binding:Binding >prep_to theme:Generic_entityt#interceding-token ngrams: and p18 .t.e1: ents2Label-mention-ngram: GENERIC_ENTITY ,t^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] Generic_entitytRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:Generic_entityt!interceding-token ngrams: Loss oft$interceding-token ngrams: componentst5e1: ents2Label-mention-ngram: resident GENERIC_ENTITYt$interceding-token ngrams: the MP-1 /t'interceding-token ngrams: components oft,e1: ents2Label-mention-ngram: late-endosomalt interceding-token ngrams: . LosstGe1: trigger-arg-path: binding >prep_to [lemma='protein'] Generic_entityt$e1: args2Role-mention-ngram: , THEMEt5e2: trigger-arg-path: Binding >nn [lemma='p14'] themetDe1: ents2Label-mention-ngram: late-endosomal resident GENERIC_ENTITYtBe1: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p18'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p14'] themetDe2: trigger-arg-path: Binding >nn [lemma='p14'] Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='p14'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binding >prep_to [lemma='protein'] themet+interceding-token ngrams: components of thet:e1: trigger-arg-path: binding >prep_to [lemma='p14'] themet5e2: trigger-arg-path: complex >nn [lemma='p14'] themetRe2: trigger-arg-path: complex:Binding >nn [lemma='p14'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='p14'] theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: late-endosomal residentt%interceding-token ngrams: of the MP-1tOe1: trigger-arg-path: Binding >prep_to [lemma='p14'] theme:Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='p18'] themetde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p18'] theme:Gene_or_gene_productt interceding-token ngrams: MP-1 /tIe1: trigger-arg-path: binding >prep_to [lemma='p14'] Gene_or_gene_productt$interceding-token ngrams: individualt'interceding-token ngrams: of individualtXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p18'] themetLe2: trigger-arg-path: complex:Binding >nn [lemma='p14'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to theme:Generic_entityt:e1: trigger-arg-path: Binding >prep_to [lemma='p14'] themet>e1: trigger-arg-path: Binding >prep_to [lemma='protein'] themet5e1: ents2Label-mention-ngram: GENERIC_ENTITY , SHAREDtDe2: trigger-arg-path: complex >nn [lemma='p18'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p14'] Gene_or_gene_productt#interceding-token ngrams: . Loss oft\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p18'] theme:Gene_or_gene_productt2interceding-token ngrams: individual components oftIe1: trigger-arg-path: Binding >prep_to [lemma='p14'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >prep_to [lemma='protein'] Generic_entitytJe2: trigger-arg-path: complex >nn [lemma='p18'] theme:Gene_or_gene_producttQe1: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: the late-endosomal residenttJe2: trigger-arg-path: Binding >nn [lemma='p18'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding >prep_to [lemma='p14'] theme:Gene_or_gene_producttinterceding-token ngrams: p18t^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p14'] Gene_or_gene_productt%e1: args2Role-mention-ngram: residentt!interceding-token ngrams: and p18tinterceding-token ngrams: MP-1t:e1: args2Role-mention-ngram: late-endosomal resident THEMEt-e1: args2Role-mention-ngram: resident THEME ,t2interceding-token ngrams: of individual componentst7e1: ents2Label-mention-ngram: resident GENERIC_ENTITY ,t2e1: args2Role-mention-ngram: to the late-endosomalt+e1: args2Role-mention-ngram: resident THEMEt&e1: ents2Label-mention-ngram: residentt5e2: trigger-arg-path: Binding >nn [lemma='p18'] themet5e1: trigger-arg-path: Binding >prep_to Generic_entitytGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p18'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to Generic_entityt3e1: ents2Label-mention-ngram: to the late-endosomaltFe1: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] themetMe1: trigger-arg-path: binding >prep_to [lemma='protein'] theme:Generic_entityt+e1: args2Role-mention-ngram: late-endosomalt=e2: trigger-arg-path: complex:Binding >nn [lemma='p14'] themetRe2: trigger-arg-path: complex:Binding >nn [lemma='p18'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] Generic_entityt3CSSPATH: ROOT >prep_by_means_of ++ ROOT >dep >nsubjtinterceding-token ngrams: p18 .t\e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] theme:Generic_entitytOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='p14'] themet5e2: trigger-arg-path: complex >nn [lemma='p18'] themet8e1: args2Role-mention-ngram: the late-endosomal residenttDe2: trigger-arg-path: Binding >nn [lemma='p18'] Gene_or_gene_productt/interceding-token ngrams: individual componentst,interceding-token ngrams: Loss of individualt/e1: args2Role-mention-ngram: the late-endosomalt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME , THEMEtWe1: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='p18'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] themetinterceding-token ngrams: Losstfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to Generic_entitytIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] themetSinterceding-tokens-full-span: and p18 . Loss of individual components of the MP-1 /tMe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] themet;e1: trigger-arg-path: binding >prep_to theme:Generic_entitytVe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] Generic_entitytVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='p18'] Gene_or_gene_producttUe1: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] theme:Generic_entitytRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding e1: trigger-arg-path: complex >amod theme:Gene_or_gene_productt8e1: trigger-arg-path: complex >amod Gene_or_gene_producttLe1: trigger-arg-path: Binding >amod [lemma='snf-chromatin-remodeling'] themet8e1: trigger-arg-path: Binding >amod Gene_or_gene_producttJe1: trigger-arg-path: complex amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=complex amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod themet1e1: trigger-arg-path: complex:Binding >amod themet;e2: trigger-arg-path: lemmatizedTrigger=complex >amod themetse1: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttae2: trigger-arg-path: Binding >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=complex >amod Gene_or_gene_productt;e2: trigger-arg-path: complex amod Gene_or_gene_producttTe1: trigger-arg-path: complex:Binding >amod [lemma='snf-chromatin-remodeling'] themetMe1: trigger-arg-path: lemmatizedTrigger=complex amod [lemma='snf-chromatin-remodeling'] themetbe2: trigger-arg-path: lemmatizedTrigger=complex amod theme:Gene_or_gene_productt>e2: trigger-arg-path: complex >amod theme:Gene_or_gene_producttie1: trigger-arg-path: complex:Binding >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_productt;e1: trigger-arg-path: lemmatizedTrigger=complex >amod themet>e1: trigger-arg-path: Binding >amod theme:Gene_or_gene_productt)e1: trigger-arg-path: complex >amod themet{e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_productt1e2: trigger-arg-path: complex:Binding >amod themet;e2: trigger-arg-path: Binding amod Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=complex:Binding amod Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='snf-chromatin-remodeling'] themet;e1: trigger-arg-path: complex amod Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod themet8e2: trigger-arg-path: Binding >amod Gene_or_gene_producttCe1: trigger-arg-path: complex:Binding amod theme:Gene_or_gene_productt@e1: trigger-arg-path: complex:Binding >amod Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod theme:Gene_or_gene_producttie2: trigger-arg-path: complex:Binding >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex e2: trigger-arg-path: Binding >amod theme:Gene_or_gene_producttLe2: trigger-arg-path: complex >amod [lemma='snf-chromatin-remodeling'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex >amod theme:Gene_or_gene_producttPe2: trigger-arg-path: Binding amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_productt[e1: trigger-arg-path: complex >amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex >amod theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding amod themetPe2: trigger-arg-path: complex amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_producttLe1: trigger-arg-path: complex >amod [lemma='snf-chromatin-remodeling'] themetae1: trigger-arg-path: complex >amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttFe2: trigger-arg-path: complex:Binding >amod theme:Gene_or_gene_producttPe1: trigger-arg-path: complex amod [lemma='snf-chromatin-remodeling'] themetde1: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='snf-chromatin-remodeling'] themetUe1: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_productt[e2: trigger-arg-path: complex >amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_producttJe2: trigger-arg-path: complex amod [lemma='snf-chromatin-remodeling'] theme:Gene_or_gene_producttCe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod themetLe2: trigger-arg-path: Binding >amod [lemma='snf-chromatin-remodeling'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='snf-chromatin-remodeling'] themetUe2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_productt)e1: trigger-arg-path: Binding >amod themet[e1: trigger-arg-path: Binding >amod [lemma='snf-chromatin-remodeling'] Gene_or_gene_producttKe2: trigger-arg-path: induced:Positive_activation >dobj >prep_of controlledtBe1: ents2Label-mention-ngram: associated with GENE_OR_GENE_PRODUCTt!interceding-token ngrams: Galphast/e2: args2Role-mention-ngram: induced release oftee2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='igf-1'] controller:Gene_or_gene_producttBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced releaset*interceding-token ngrams: demonstrated thetLe2: trigger-arg-path: induced >dobj >prep_of controlled:Gene_or_gene_productt|e2: trigger-arg-path: Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlled:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubjpass [lemma='subunit'] Gene_or_gene_producttKe1: trigger-arg-path: associated:Binding >nsubjpass [lemma='subunit'] themethe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='igf-1'] controller:Gene_or_gene_producttTe2: trigger-arg-path: induced >nsubj [lemma='igf-1'] controller:Gene_or_gene_productt@e1: trigger-arg-path: Binding >nsubjpass [lemma='subunit'] themet interceding-token ngrams: type .t#interceding-token ngrams: IGF-1R int[e2: trigger-arg-path: induced >dobj [lemma='release'] >prep_of [lemma='subunit'] controlledtZe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='igf-1'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: induced release oft interceding-token ngrams: IGF-1Rt+e2: args2Role-mention-ngram: release of thetinterceding-token ngrams: typetye2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='igf-1'] controller:Gene_or_gene_producttUe2: trigger-arg-path: Positive_activation >nsubj [lemma='igf-1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: release of thet)interceding-token ngrams: with the IGF-1Rtoe2: trigger-arg-path: induced:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlledt\e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of controlledtde2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='igf-1'] controllert1interceding-token ngrams: this study demonstratedtHe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of controlledtUe1: trigger-arg-path: Binding >nsubjpass [lemma='subunit'] theme:Gene_or_gene_productt7e2: args2Role-mention-ngram: CONTROLLER induced releasetpe2: trigger-arg-path: induced >dobj [lemma='release'] >prep_of [lemma='subunit'] controlled:Gene_or_gene_productt?interceding-tokens-full-span: while Galphas was not associated with the IGF-1R in any cell type . More importantly , this study demonstrated thet?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlledt?e2: trigger-arg-path: induced:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='subunit'] themet,interceding-token ngrams: . More importantlyt?e2: trigger-arg-path: induced >nsubj [lemma='igf-1'] controllertqe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='subunit'] theme:Gene_or_gene_productt`e1: trigger-arg-path: associated:Binding >nsubjpass [lemma='subunit'] theme:Gene_or_gene_productt,interceding-token ngrams: study demonstratedt%interceding-token ngrams: Galphas wastie1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='subunit'] theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='igf-1'] Gene_or_gene_producttSe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='igf-1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='release'] >prep_of [lemma='subunit'] controlled:Gene_or_gene_productt'interceding-token ngrams: importantly ,t%e2: ents2Label-mention-ngram: releaset%interceding-token ngrams: type . MoretRe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of Gene_or_gene_productt"interceding-token ngrams: any cellt)interceding-token ngrams: Galphas was nott'e1: args2Role-mention-ngram: THEME weret#interceding-token ngrams: cell typet4e1: ents2Label-mention-ngram: SHARED were associatedt%interceding-token ngrams: in any cellt7e2: trigger-arg-path: induced >dobj >prep_of controlledtle2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='release'] >prep_of [lemma='subunit'] controlledt`e2: trigger-arg-path: Positive_activation >nsubj [lemma='igf-1'] controller:Gene_or_gene_productt`e2: trigger-arg-path: induced:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt%interceding-token ngrams: importantlyt%interceding-token ngrams: cell type .t-e2: ents2Label-mention-ngram: induced releasetfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of Gene_or_gene_productt&interceding-token ngrams: , this studytye2: trigger-arg-path: induced:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] Gene_or_gene_productt'interceding-token ngrams: the IGF-1R intge2: trigger-arg-path: Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlledtCe1: trigger-arg-path: associated >nsubjpass [lemma='subunit'] themetRe1: trigger-arg-path: associated >nsubjpass [lemma='subunit'] Gene_or_gene_producttAe2: trigger-arg-path: induced >dobj >prep_of Gene_or_gene_producttUe2: trigger-arg-path: induced:Positive_activation >dobj >prep_of Gene_or_gene_productt interceding-token ngrams: in anyt,e2: args2Role-mention-ngram: induced releaset'interceding-token ngrams: while Galphastinterceding-token ngrams: Moretce1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='subunit'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=induce >dobj >prep_of controlled:Gene_or_gene_productt interceding-token ngrams: . Moretke1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubjpass [lemma='subunit'] Gene_or_gene_productt(interceding-token ngrams: not associatedt0interceding-token ngrams: study demonstrated thetPe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='igf-1'] controllertinterceding-token ngrams: anyt*interceding-token ngrams: More importantlytZe1: trigger-arg-path: associated:Binding >nsubjpass [lemma='subunit'] Gene_or_gene_productt$e2: args2Role-mention-ngram: releaset'interceding-token ngrams: any cell typet?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] Gene_or_gene_productt]e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='igf-1'] Gene_or_gene_productt$interceding-token ngrams: this studyt)e1: ents2Label-mention-ngram: SHARED weret,interceding-token ngrams: was not associatedt-interceding-token ngrams: not associated withtqe2: trigger-arg-path: Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_activation >nsubj [lemma='igf-1'] controllertve2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='release'] >prep_of [lemma='subunit'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: release oftqe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt'interceding-token ngrams: IGF-1R in anyt,interceding-token ngrams: importantly , thistee2: trigger-arg-path: induced >dobj [lemma='release'] >prep_of [lemma='subunit'] Gene_or_gene_productt,interceding-token ngrams: More importantly ,tXe1: trigger-arg-path: associated >nsubjpass [lemma='subunit'] theme:Gene_or_gene_productt$interceding-token ngrams: the IGF-1Rt2e1: args2Role-mention-ngram: THEME were associatedt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='release'] >prep_of [lemma='subunit'] controlled:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=associate >nsubjpass [lemma='subunit'] themetIe2: trigger-arg-path: induced >nsubj [lemma='igf-1'] Gene_or_gene_productt+interceding-token ngrams: while Galphas wast'e2: args2Role-mention-ngram: release oft!interceding-token ngrams: and Raft-interceding-token ngrams: yet been determinedt&interceding-token ngrams: . Given thatt,interceding-token ngrams: determined . Givent"interceding-token ngrams: also nott(interceding-token ngrams: GTPase and RBDt!interceding-token ngrams: that ittinterceding-token ngrams: Givent%interceding-token ngrams: Ras and RaftYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mcp110'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mcp110'] themetHe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] themetIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] Familyt$interceding-token ngrams: Given thatt'interceding-token ngrams: Given that itt+e2: trigger-arg-path: binds >prep_to Familyt7e2: trigger-arg-path: binds >prep_to [lemma='ra'] themetAe2: trigger-arg-path: binds:Binding >nsubj [lemma='mcp110'] themet&interceding-token ngrams: determined .tPe2: trigger-arg-path: binds:Binding >nsubj [lemma='mcp110'] Gene_or_gene_productt8e2: trigger-arg-path: binds >prep_to [lemma='ra'] Familyt>e2: trigger-arg-path: binds >prep_to [lemma='ra'] theme:Familyt.interceding-token ngrams: interactions betweentFe2: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] theme:FamilytOe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ra'] theme:Familyt3interceding-token ngrams: presently unclear whethertQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] Familyt1e2: trigger-arg-path: binds >prep_to theme:Familyt-interceding-token ngrams: versus other GTPaset&interceding-token ngrams: other GTPaset@e2: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] FamilytJe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mcp110'] themetNe2: trigger-arg-path: binds >nsubj [lemma='mcp110'] theme:Gene_or_gene_productt+interceding-token ngrams: presently uncleart interceding-token ngrams: versust&interceding-token ngrams: also not yettPe2: trigger-arg-path: Binding >nsubj [lemma='mcp110'] theme:Gene_or_gene_productt)interceding-token ngrams: unclear whethert*interceding-token ngrams: other GTPase andt9e2: trigger-arg-path: binds >nsubj [lemma='mcp110'] themet.interceding-token ngrams: is presently uncleart2interceding-token ngrams: interactions between Rast(interceding-token ngrams: and Raf versustHe2: trigger-arg-path: binds >nsubj [lemma='mcp110'] Gene_or_gene_productt9e2: trigger-arg-path: binds:Binding >prep_to theme:Familyt@e2: trigger-arg-path: Binding >prep_to [lemma='ra'] theme:FamilytWe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] theme:Familyt6interceding-token ngrams: disrupt interactions betweent:e2: trigger-arg-path: Binding >prep_to [lemma='ra'] Familyt#interceding-token ngrams: RBD pairstinterceding-token ngrams: RBDt;e2: trigger-arg-path: Binding >nsubj [lemma='mcp110'] themet$interceding-token ngrams: Raf versustJe2: trigger-arg-path: Binding >nsubj [lemma='mcp110'] Gene_or_gene_productt!interceding-token ngrams: and RBDt)interceding-token ngrams: between Ras andt$interceding-token ngrams: GTPase andt?interceding-tokens-full-span: , but the selectivity of MCP110 to disrupt interactions between Ras and Raf versus other GTPase and RBD pairs has also not yet been determined . Given that it is presently unclear whethert3e2: trigger-arg-path: binds:Binding >prep_to Familyt&interceding-token ngrams: interactionst'interceding-token ngrams: RBD pairs hast#interceding-token ngrams: pairs hast+interceding-token ngrams: been determined .tPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ra'] themet$interceding-token ngrams: that it ist?e2: trigger-arg-path: binds:Binding >prep_to [lemma='ra'] themet9e2: trigger-arg-path: Binding >prep_to [lemma='ra'] themet%interceding-token ngrams: between Rast#interceding-token ngrams: presentlyt)interceding-token ngrams: it is presentlytVe2: trigger-arg-path: binds:Binding >nsubj [lemma='mcp110'] theme:Gene_or_gene_producttinterceding-token ngrams: pairstge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mcp110'] theme:Gene_or_gene_productt&interceding-token ngrams: has also nott(interceding-token ngrams: pairs has alsot1interceding-token ngrams: to disrupt interactionst_e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mcp110'] theme:Gene_or_gene_productt!interceding-token ngrams: uncleart&interceding-token ngrams: versus othertae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mcp110'] Gene_or_gene_productt!interceding-token ngrams: . Givent interceding-token ngrams: GTPaset)interceding-token ngrams: been determinedt7CSSPATH: ROOT >dobj >prep_of ++ ROOT >dep >pcomp >ccomptinterceding-token ngrams: Raft&interceding-token ngrams: is presentlyt.interceding-token ngrams: disrupt interactionst*interceding-token ngrams: Raf versus othert'interceding-token ngrams: and RBD pairstMe1: trigger-arg-path: Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn sitetxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: S734 , andt(interceding-token ngrams: and cell deathtinterceding-token ngrams: PRC2t?e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetye1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt interceding-token ngrams: , EZH2tWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn site:SitetOe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn site:Sitetconj_and >nsubj >nn site:Sitet8e1: trigger-arg-path: Binding >nsubj [lemma='ATM'] themet&interceding-token ngrams: EZH2 reducest*e1: args2Role-mention-ngram: THEME at S734t9e1: trigger-arg-path: interacts >conj_and >nsubj >nn SitetSe2: trigger-arg-path: mediated >nsubj [lemma='ATM'] controller:Gene_or_gene_productt*interceding-token ngrams: death in neuronst&e1: args2Role-mention-ngram: at S734 ,tie1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: S734 , andt)interceding-token ngrams: assembly , EZH2t\e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] controllertinterceding-token ngrams: EZH2t'interceding-token ngrams: cell death intme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitetse1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt)interceding-token ngrams: PRC2 assembly ,t$interceding-token ngrams: cell deatht$e1: ents2Label-mention-ngram: S734 ,t&e1: ents2Label-mention-ngram: and S734tde1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themet?e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet\e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_producttOe1: trigger-arg-path: interacts >nsubj [lemma='ATM'] theme:Gene_or_gene_producttqe1: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet&interceding-token ngrams: reduces PRC2tJe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >nsubj >nn Sitetinterceding-token ngrams: deatht!e1: args2Role-mention-ngram: S734t%e1: args2Role-mention-ngram: and SITEt!interceding-token ngrams: of EZH2tKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] themet:e1: trigger-arg-path: interacts >nsubj [lemma='ATM'] themetAe1: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn sitet$interceding-token ngrams: , and celltbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: , and S734tRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn sitetSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] themetde2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] controller:Gene_or_gene_productt#interceding-token ngrams: neurons .tqe1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_producttse1: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitet'e1: ents2Label-mention-ngram: at S734 ,t$e1: args2Role-mention-ngram: at S734tge2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: S734 ,t!interceding-token ngrams: neuronstve1: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitetoe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt{e1: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn site:SitetYe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] Gene_or_gene_productt"interceding-token ngrams: death int$interceding-token ngrams: assembly ,t/interceding-token ngrams: reduces PRC2 assemblytRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >nsubj >nn Sitet>e1: trigger-arg-path: interacts >conj_and >nsubj >nn site:Sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitetke1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='ATM'] Gene_or_gene_productt&interceding-token ngrams: in neurons .t!interceding-token ngrams: reducesthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_productt"interceding-token ngrams: and cellt?e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ATM'] theme:Gene_or_gene_producttzinterceding-tokens-full-span: phosphorylation of EZH2 reduces PRC2 assembly , EZH2 stability , and cell death in neurons .t1interceding-token ngrams: phosphorylation of EZH2t?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitet?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt{e1: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet"interceding-token ngrams: assemblyt?e1: trigger-arg-path: interacts:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:Sitet7e1: trigger-arg-path: Binding >conj_and >nsubj >nn sitet'e1: args2Role-mention-ngram: , and SITEtWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] theme:Gene_or_gene_producttQe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] Gene_or_gene_producttRe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ATM'] controllertce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] controllert)interceding-token ngrams: stability , andtAe1: trigger-arg-path: interacts:Binding >conj_and >nsubj >nn Sitet+interceding-token ngrams: EZH2 reduces PRC2tue1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetse1: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet*interceding-token ngrams: EZH2 stability ,t>e2: trigger-arg-path: mediated >nsubj [lemma='ATM'] controllert$interceding-token ngrams: in neuronstBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ATM'] themetSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt(interceding-token ngrams: EZH2 stabilitytOe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] controllert?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] Sitet'interceding-token ngrams: PRC2 assemblyt|e1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] Gene_or_gene_productt)interceding-token ngrams: of EZH2 reducest7e1: trigger-arg-path: Binding >conj_and >nsubj >nn Sitetxe1: trigger-arg-path: interacts >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] site:SitetZe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetme1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='ezh2'] themetHe2: trigger-arg-path: mediated >nsubj [lemma='ATM'] Gene_or_gene_productt*interceding-token ngrams: , EZH2 stabilityt9e1: trigger-arg-path: interacts >conj_and >nsubj >nn sitetqe1: trigger-arg-path: Binding >conj_and [lemma='reduce'] >nsubj [lemma='phosphorylation'] >nn [lemma='s734'] sitetIe1: trigger-arg-path: interacts >nsubj [lemma='ATM'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='it'] Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj controlledtNe2: trigger-arg-path: enhanced:Positive_regulation >nsubj Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED is insufficienttGe1: trigger-arg-path: increase >dobj [lemma='atr'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='topbp1'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: Dbp11 ,t'e2: ents2Label-mention-ngram: protein 1t*e2: args2Role-mention-ngram: of yeast Cut5t'e2: ents2Label-mention-ngram: homologuet&e2: args2Role-mention-ngram: homologuetFe1: trigger-arg-path: increase nsubj controller:Generic_entitytje1: trigger-arg-path: increase nsubj [lemma='it'] controller:Generic_entitytBe1: trigger-arg-path: Positive_activation nsubj controllertMe1: trigger-arg-path: increase:Positive_activation >dobj Gene_or_gene_productt5e2: args2Role-mention-ngram: , significantly enhancedt e2: args2Role-mention-ngram: 1 )t7e2: args2Role-mention-ngram: CONTROLLER ( topoisomerasetKe1: trigger-arg-path: lemmatizedTrigger=increase >dobj Gene_or_gene_productt!interceding-token ngrams: derivedt*e1: ents2Label-mention-ngram: insufficienttMe1: trigger-arg-path: lemmatizedTrigger=increase nsubj Generic_entityt[e1: trigger-arg-path: increase:Positive_activation >dobj [lemma='atr'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: of yeastt7e2: args2Role-mention-ngram: significantly enhanced thetQe1: trigger-arg-path: increase:Positive_activation >dobj [lemma='atr'] controlledt/e2: ents2Label-mention-ngram: binding protein 1t:e2: trigger-arg-path: enhanced >nsubj Gene_or_gene_productt"e2: ents2Label-mention-ngram: Cut5t]e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj controllertKe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='atr'] controlled:Gene_or_gene_productt,e1: args2Role-mention-ngram: insufficient tot+interceding-token ngrams: analysis revealedt_e2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='topbp1'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: insufficient to increasetge2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='topbp1'] controller:Gene_or_gene_productt7e1: trigger-arg-path: increase nsubj controllert4e2: ents2Label-mention-ngram: significantly enhancedtje2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='topbp1'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: mammalian homologuet)e2: args2Role-mention-ngram: homologue oft&e2: args2Role-mention-ngram: protein 1tHe1: trigger-arg-path: Positive_activation >dobj [lemma='atr'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='it'] controllertRe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='topbp1'] controllertje1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj controlled:Gene_or_gene_productt3e2: ents2Label-mention-ngram: topoisomerase bindingt5e2: ents2Label-mention-ngram: the mammalian homologuetfe1: trigger-arg-path: Positive_activation nsubj [lemma='it'] controllert#e2: ents2Label-mention-ngram: 1 ) ,t+e2: ents2Label-mention-ngram: of yeast Cut5t-e1: ents2Label-mention-ngram: is insufficienttXe1: trigger-arg-path: lemmatizedTrigger=increase nsubj controller:Generic_entityt'e2: ents2Label-mention-ngram: and Dbp11t\e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='topbp1'] Gene_or_gene_productt&e2: args2Role-mention-ngram: and Dbp11t%e2: ents2Label-mention-ngram: ) , thet5e1: args2Role-mention-ngram: insufficient to increasetLe2: trigger-arg-path: Positive_regulation >nsubj [lemma='topbp1'] controllertoe1: trigger-arg-path: increase:Positive_activation nsubj [lemma='it'] controllertDe2: trigger-arg-path: enhanced:Positive_regulation >nsubj controllert%interceding-token ngrams: BiochemicaltKe2: trigger-arg-path: enhanced >nsubj [lemma='topbp1'] Gene_or_gene_productt;e1: trigger-arg-path: increase nsubj Generic_entityt3e2: args2Role-mention-ngram: mammalian homologue oft)e2: ents2Label-mention-ngram: protein 1 )t)e1: ents2Label-mention-ngram: to increaset:e2: args2Role-mention-ngram: topoisomerase binding proteint9e1: trigger-arg-path: increase >dobj Gene_or_gene_producttRe1: trigger-arg-path: increase >dobj [lemma='atr'] controlled:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=increase nsubj controllertUe2: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='topbp1'] controllert;e2: ents2Label-mention-ngram: topoisomerase binding proteintOe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='atr'] controlledt-e2: ents2Label-mention-ngram: binding proteint*e2: ents2Label-mention-ngram: enhanced thet"e2: args2Role-mention-ngram: 1 ) ,t'interceding-token ngrams: . Biochemicalt1interceding-token ngrams: derived kinase activityt2e2: args2Role-mention-ngram: Dbp11 , significantlyt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='it'] Generic_entityt#CSSPATH: ROOT >xcomp ++ ROOT >ccompt1e2: ents2Label-mention-ngram: enhanced the kinaset-e2: ents2Label-mention-ngram: , the mammaliantse1: trigger-arg-path: increase:Positive_activation nsubj [lemma='it'] Generic_entityt-e1: ents2Label-mention-ngram: insufficient tot,e2: args2Role-mention-ngram: binding proteintQe1: trigger-arg-path: Positive_activation nsubj controller:Generic_entityt0e2: args2Role-mention-ngram: mammalian homologuetpe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='topbp1'] Gene_or_gene_productt$e2: args2Role-mention-ngram: ) , thetje2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj controller:Gene_or_gene_productt*e2: args2Role-mention-ngram: topoisomeraset&e2: args2Role-mention-ngram: mammaliant-e2: ents2Label-mention-ngram: ( topoisomeraset'e2: ents2Label-mention-ngram: mammaliant/e2: args2Role-mention-ngram: homologue of yeasttce1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='atr'] controlledtle1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj controller:Generic_entityt=e1: trigger-arg-path: increase >dobj [lemma='atr'] controlledt_e1: trigger-arg-path: increase nsubj [lemma='it'] Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='it'] controller:Generic_entitytCe1: trigger-arg-path: increase:Positive_activation >dobj controlledtae2: trigger-arg-path: Positive_regulation >nsubj [lemma='topbp1'] controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: enhanced thet*e1: args2Role-mention-ngram: CONTROLLER ist,e2: args2Role-mention-ngram: , the mammaliant|e1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='it'] controller:Generic_entityt'interceding-token ngrams: revealed thatt0interceding-token ngrams: analysis revealed thatt(e1: args2Role-mention-ngram: to increaset~e1: trigger-arg-path: increase:Positive_activation nsubj [lemma='it'] controller:Generic_entityt)e2: ents2Label-mention-ngram: and Dbp11 ,tVe1: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='atr'] Gene_or_gene_productt/e1: args2Role-mention-ngram: is insufficient tot-e2: ents2Label-mention-ngram: , significantlytfe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='topbp1'] controllertme1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='it'] controllert(e2: args2Role-mention-ngram: protein 1 )tae1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj Generic_entityt3e1: args2Role-mention-ngram: to increase CONTROLLEDtje1: trigger-arg-path: Positive_activation nsubj [lemma='it'] Generic_entityt%e2: args2Role-mention-ngram: Cut5 andt)e1: args2Role-mention-ngram: insufficientt0e2: ents2Label-mention-ngram: homologue of yeasttKe1: trigger-arg-path: increase:Positive_activation nsubj controllert"interceding-token ngrams: revealedt3e2: args2Role-mention-ngram: significantly enhancedt.interceding-token ngrams: Biochemical analysistfe1: trigger-arg-path: increase:Positive_activation >dobj [lemma='atr'] controlled:Gene_or_gene_productt,e2: args2Role-mention-ngram: ( topoisomeraset!e2: args2Role-mention-ngram: Cut5t+e2: ents2Label-mention-ngram: topoisomerasetVe2: trigger-arg-path: Positive_regulation >nsubj [lemma='topbp1'] Gene_or_gene_producttOe1: trigger-arg-path: increase:Positive_activation nsubj Generic_entitytXe1: trigger-arg-path: increase:Positive_activation >dobj controlled:Gene_or_gene_productt]e1: trigger-arg-path: Positive_activation >dobj [lemma='atr'] controlled:Gene_or_gene_productt,e2: args2Role-mention-ngram: , significantlyt0e2: args2Role-mention-ngram: enhanced the kinasetde1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='atr'] controlled:Gene_or_gene_productt7e1: args2Role-mention-ngram: CONTROLLER is insufficientt,e2: ents2Label-mention-ngram: Cut5 and Dbp11t4e2: args2Role-mention-ngram: ( topoisomerase bindingt*e2: args2Role-mention-ngram: the mammaliantue1: trigger-arg-path: Positive_activation nsubj [lemma='it'] controller:Generic_entityt!e2: ents2Label-mention-ngram: 1 )tRe1: trigger-arg-path: Positive_activation >dobj [lemma='atr'] Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controllertVe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: increase nsubj [lemma='it'] controllert0e1: ents2Label-mention-ngram: is insufficient tot0interceding-token ngrams: . Biochemical analysistYe2: trigger-arg-path: enhanced:Positive_regulation >nsubj controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: mammalian homologue oft,e1: args2Role-mention-ngram: is insufficientt4e2: args2Role-mention-ngram: the mammalian homologuet8e2: ents2Label-mention-ngram: significantly enhanced thetVe2: trigger-arg-path: enhanced >nsubj [lemma='topbp1'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: Dbp11 , significantlyt"e2: args2Role-mention-ngram: yeasttBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( topoisomeraset(e2: args2Role-mention-ngram: and Dbp11 ,tAe2: trigger-arg-path: enhanced >nsubj [lemma='topbp1'] controllertEe2: trigger-arg-path: enhanced >nsubj controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj Gene_or_gene_productt"e2: args2Role-mention-ngram: Dbp11t&e2: ents2Label-mention-ngram: Cut5 andt6e2: ents2Label-mention-ngram: , significantly enhancedt0e1: ents2Label-mention-ngram: to increase SHAREDtZinterceding-tokens-full-span: derived kinase activity . Biochemical analysis revealed thatt2e2: args2Role-mention-ngram: topoisomerase bindingt,e2: ents2Label-mention-ngram: yeast Cut5 andtUe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj controllert%e2: ents2Label-mention-ngram: Dbp11 ,t+e2: args2Role-mention-ngram: yeast Cut5 andt(interceding-token ngrams: derived kinaset#e2: ents2Label-mention-ngram: Dbp11tme1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='atr'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: homologue oft%e2: args2Role-mention-ngram: of yeastt0e2: trigger-arg-path: enhanced >nsubj controllert+e2: args2Role-mention-ngram: Cut5 and Dbp11t.e2: args2Role-mention-ngram: binding protein 1t"interceding-token ngrams: analysist+e2: ents2Label-mention-ngram: the mammaliant(e2: ents2Label-mention-ngram: yeast Cut5t#e2: ents2Label-mention-ngram: yeastt7interceding-token ngrams: Biochemical analysis revealedt0interceding-token ngrams: activity . BiochemicaltFe1: trigger-arg-path: Positive_activation nsubj Generic_entitytZe1: trigger-arg-path: increase:Positive_activation nsubj controller:Generic_entitytDe1: trigger-arg-path: increase >dobj controlled:Gene_or_gene_productt'e2: args2Role-mention-ngram: yeast Cut5t5e2: ents2Label-mention-ngram: ( topoisomerase bindingt_e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj Gene_or_gene_productt0e2: ents2Label-mention-ngram: Phosphorylation oft$e2: args2Role-mention-ngram: 2 and 5t?e1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by [lemma='cdk1'] controllertAe2: trigger-arg-path: enhances >prep_by [lemma='cdk1'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by controllert&interceding-token ngrams: activity . (tprep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , 2tpe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by [lemma='cdk1'] Gene_or_gene_productthe1: trigger-arg-path: Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controllert%interceding-token ngrams: reduces itst$e2: ents2Label-mention-ngram: Ser154t8interceding-token ngrams: its methyltransferase activitytFe2: trigger-arg-path: enhances:Positive_regulation >prep_by controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] Gene_or_gene_productte2: args2Role-mention-ngram: 5tPe2: trigger-arg-path: enhances:Positive_regulation >prep_by Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controller:Gene_or_gene_producttUe2: trigger-arg-path: enhances:Positive_regulation >prep_by [lemma='cdk1'] controllert6interceding-token ngrams: methyltransferase activity .t"e2: args2Role-mention-ngram: 2 andt"e2: args2Role-mention-ngram: and 5t_e2: trigger-arg-path: enhances:Positive_regulation >prep_by [lemma='cdk1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controllert/interceding-token ngrams: its methyltransferaset#e2: ents2Label-mention-ngram: and 5t4interceding-token ngrams: methyltransferase activityt[e2: trigger-arg-path: enhances:Positive_regulation >prep_by controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: CONTROLLER , 2tKe2: trigger-arg-path: enhances >prep_by [lemma='cdk1'] Gene_or_gene_productt#e2: ents2Label-mention-ngram: 2 andtVe2: trigger-arg-path: Positive_regulation >prep_by [lemma='cdk1'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: PhosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by controller:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by Gene_or_gene_productt,e2: ents2Label-mention-ngram: and 5 enhancest!e2: ents2Label-mention-ngram: , 2tje2: trigger-arg-path: enhances:Positive_regulation >prep_by [lemma='cdk1'] controller:Gene_or_gene_productt+interceding-token ngrams: methyltransferasetae2: trigger-arg-path: Positive_regulation >prep_by [lemma='cdk1'] controller:Gene_or_gene_productte2: ents2Label-mention-ngram: 5tprep_by Gene_or_gene_productt%e2: ents2Label-mention-ngram: , 2 andtinterceding-token ngrams: ( CtLinterceding-tokens-full-span: reduces its methyltransferase activity . ( C )tinterceding-token ngrams: ( C )t,e2: args2Role-mention-ngram: by CONTROLLER ,t+e2: args2Role-mention-ngram: and 5 enhancestve1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controllertye1: trigger-arg-path: Phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt}e1: trigger-arg-path: Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controller:Gene_or_gene_producttCSSPATH: ROOT >nsubj ++ ROOT tae2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by Gene_or_gene_producttinterceding-token ngrams: . ( Ctne1: trigger-arg-path: Phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by [lemma='cdk1'] controllertre1: trigger-arg-path: Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: 5 enhancestLe2: trigger-arg-path: Positive_regulation >prep_by [lemma='cdk1'] controllertinterceding-token ngrams: Ct.e2: ents2Label-mention-ngram: SHARED at Ser154t$e2: args2Role-mention-ngram: , 2 andtVe2: trigger-arg-path: enhances >prep_by [lemma='cdk1'] controller:Gene_or_gene_productt e2: args2Role-mention-ngram: , 2t*e2: ents2Label-mention-ngram: at Ser154 byt'e2: args2Role-mention-ngram: 5 enhancest7e2: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCT ,t7interceding-token ngrams: reduces its methyltransferaset7e2: ents2Label-mention-ngram: Phosphorylation of SHAREDt'e2: ents2Label-mention-ngram: at Ser154t{e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by [lemma='cdk1'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: 2 and 5tGe2: trigger-arg-path: enhances >prep_by controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: Ser154 bytde1: trigger-arg-path: Phosphorylation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controllertxe1: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='dnmt1'] >prep_by [lemma='pkczeta'] controllertCe2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by controllertge2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by [lemma='cdk1'] controller:Gene_or_gene_productt2e2: trigger-arg-path: enhances >prep_by controllert\e2: trigger-arg-path: lemmatizedTrigger=enhance >prep_by [lemma='cdk1'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >prep_by controller:Gene_or_gene_productt(interceding-token ngrams: . Conversely ,t+interceding-token ngrams: of Pak1 abrogatedt!interceding-token ngrams: of Pak1t[e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam-flag'] themet,interceding-token ngrams: of the ectopicallyt5e1: args2Role-mention-ngram: between endogenous THEMEt+interceding-token ngrams: knockdown of Pak1tMe1: trigger-arg-path: association:Binding >prep_between [lemma='pgam'] Familytae1: trigger-arg-path: association:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt8interceding-token ngrams: ectopically expressed proteinst+interceding-token ngrams: MEFs . Converselyt_e2: trigger-arg-path: interactions >prep_between [lemma='pgam-flag'] theme:Gene_or_gene_productt%interceding-token ngrams: proteins int3interceding-token ngrams: the ectopically expressedt^e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='mdm2'] themet3e1: ents2Label-mention-ngram: endogenous FAMILY andt,interceding-token ngrams: Conversely , shRNAt!interceding-token ngrams: , shRNAt>e1: trigger-arg-path: association:Binding >prep_between Familytae2: trigger-arg-path: interactions:Binding >prep_between [lemma='pgam-flag'] Gene_or_gene_producttfe2: trigger-arg-path: interactions:Binding >prep_between [lemma='myc-mdm2'] theme:Gene_or_gene_producttYe2: trigger-arg-path: Binding >prep_between [lemma='myc-mdm2'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam-flag'] themet$interceding-token ngrams: in primarytinterceding-token ngrams: MEFst-e1: args2Role-mention-ngram: endogenous THEMEt&interceding-token ngrams: knockdown oftVe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='pgam'] themetSe2: trigger-arg-path: Binding >prep_between [lemma='myc-mdm2'] Gene_or_gene_productt interceding-token ngrams: in DKOt"interceding-token ngrams: physicaltIe2: trigger-arg-path: interactions >prep_between [lemma='myc-mdm2'] themet?interceding-tokens-full-span: in primary MEFs and also of the ectopically expressed proteins in DKO MEFs . Conversely , shRNA mediated knockdown of Pak1 abrogated the physicalt&interceding-token ngrams: . Converselyt"interceding-token ngrams: MEFs andtwe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='myc-mdm2'] theme:Gene_or_gene_productt!interceding-token ngrams: also oft2interceding-token ngrams: shRNA mediated knockdownt#interceding-token ngrams: expressedtAe1: trigger-arg-path: Binding >prep_between [lemma='pgam'] FamilytVe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between theme:Familyt%interceding-token ngrams: ectopicallyt]e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='pgam'] theme:Familyt)interceding-token ngrams: in primary MEFst0interceding-token ngrams: abrogated the physicaltinterceding-token ngrams: DKOtje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam-flag'] Gene_or_gene_producttJe2: trigger-arg-path: interactions >prep_between [lemma='pgam-flag'] themet/interceding-token ngrams: ectopically expressedt,interceding-token ngrams: Pak1 abrogated thetqe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='myc-mdm2'] Gene_or_gene_producttRe2: trigger-arg-path: interactions:Binding >prep_between [lemma='pgam-flag'] themet$interceding-token ngrams: Converselytoe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='myc-mdm2'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='mdm2'] themet1e1: args2Role-mention-ngram: endogenous THEME andtYe1: trigger-arg-path: association >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt&interceding-token ngrams: primary MEFst*interceding-token ngrams: primary MEFs andt7e1: ents2Label-mention-ngram: between endogenous FAMILYt'e1: args2Role-mention-ngram: endogenoustEe2: trigger-arg-path: Binding >prep_between [lemma='pgam-flag'] themet(e1: ents2Label-mention-ngram: endogenoustse1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt(CSSPATH: ROOT >dobj ++ ROOT >ccomp >dobjtYe2: trigger-arg-path: interactions >prep_between [lemma='pgam-flag'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam-flag'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=association >prep_between theme:Familyt`e2: trigger-arg-path: interactions:Binding >prep_between [lemma='myc-mdm2'] Gene_or_gene_productt%interceding-token ngrams: and also oft)interceding-token ngrams: proteins in DKOt%interceding-token ngrams: in DKO MEFstZe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='myc-mdm2'] themetme1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='mdm2'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam-flag'] Gene_or_gene_productt[e1: trigger-arg-path: association:Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: FAMILY and SHAREDt#interceding-token ngrams: knockdownt^e2: trigger-arg-path: interactions >prep_between [lemma='myc-mdm2'] theme:Gene_or_gene_productt;e1: args2Role-mention-ngram: association between endogenoust/e1: args2Role-mention-ngram: between endogenoustPe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between FamilytHe1: trigger-arg-path: lemmatizedTrigger=association >prep_between FamilytSe1: trigger-arg-path: association >prep_between [lemma='mdm2'] Gene_or_gene_productt"interceding-token ngrams: DKO MEFstTe2: trigger-arg-path: Binding >prep_between [lemma='pgam-flag'] Gene_or_gene_producttDe1: trigger-arg-path: association:Binding >prep_between theme:FamilytZe2: trigger-arg-path: Binding >prep_between [lemma='pgam-flag'] theme:Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='pgam'] themetee1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='mdm2'] Gene_or_gene_producttLe1: trigger-arg-path: association:Binding >prep_between [lemma='mdm2'] themetXe2: trigger-arg-path: interactions >prep_between [lemma='myc-mdm2'] Gene_or_gene_productt)interceding-token ngrams: the ectopicallytDe1: trigger-arg-path: association >prep_between [lemma='mdm2'] themetxe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam-flag'] theme:Gene_or_gene_productt6e1: trigger-arg-path: association >prep_between Familyt/interceding-token ngrams: mediated knockdown oft0e1: ents2Label-mention-ngram: between endogenoust(interceding-token ngrams: shRNA mediatedtLe1: trigger-arg-path: association:Binding >prep_between [lemma='pgam'] themetprep_between theme:FamilytGe1: trigger-arg-path: Binding >prep_between [lemma='pgam'] theme:Familytinterceding-token ngrams: shRNAt%interceding-token ngrams: also of thetie2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='myc-mdm2'] Gene_or_gene_producttDe1: trigger-arg-path: association >prep_between [lemma='pgam'] themet$interceding-token ngrams: DKO MEFs .t/e1: ents2Label-mention-ngram: endogenous FAMILYtinterceding-token ngrams: Pak1t,interceding-token ngrams: expressed proteinstEe1: trigger-arg-path: association >prep_between [lemma='pgam'] Familyt&interceding-token ngrams: the physicalt(interceding-token ngrams: Pak1 abrogatedt*interceding-token ngrams: , shRNA mediatedtke1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt interceding-token ngrams: MEFs .tSe1: trigger-arg-path: association:Binding >prep_between [lemma='pgam'] theme:Familyt&interceding-token ngrams: Conversely ,tbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='myc-mdm2'] themet!interceding-token ngrams: primaryt_e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='pgam'] FamilytKe1: trigger-arg-path: association >prep_between [lemma='pgam'] theme:Familytprep_between [lemma='pgam-flag'] theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='pgam'] Familytee1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='pgam'] theme:Familyt'interceding-token ngrams: MEFs and alsot/interceding-token ngrams: expressed proteins int'interceding-token ngrams: abrogated thetDe2: trigger-arg-path: Binding >prep_between [lemma='myc-mdm2'] themet,interceding-token ngrams: mediated knockdowntQe2: trigger-arg-path: interactions:Binding >prep_between [lemma='myc-mdm2'] themet^e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='pgam'] themet,e1: ents2Label-mention-ngram: SHARED is alsot*interceding-token ngrams: decrease its DNAtZe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj Phosphorylationtte2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt,interceding-token ngrams: cells with okadaictwe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controller:Familytie1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='casein'] Familyt!interceding-token ngrams: okadaictke2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] controlled:PhosphorylationtIe2: trigger-arg-path: increases:Positive_regulation >dobj Phosphorylationtce1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='casein'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controller:Simple_chemicalt.e1: ents2Label-mention-ngram: Thr668 by FAMILYt}e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] Familyt?e2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controller:Simple_chemicaltae1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controllertQe2: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:PhosphorylationtXe1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='casein'] FamilytGe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent >nn FamilytTe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_with Simple_chemicaltfe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent >nn controller:Familyt^e2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of >prep_with Simple_chemicaltOe2: trigger-arg-path: increases >dobj [lemma='phosphorylation'] Phosphorylationt1e1: ents2Label-mention-ngram: also phosphorylatedt)interceding-token ngrams: to decrease itst\e1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='casein'] controllert%interceding-token ngrams: , treatmentt5e2: trigger-arg-path: increases >dobj Phosphorylationt;e1: trigger-arg-path: Positive_regulation >agent >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controllert?interceding-tokens-full-span: kinase II ( CKII ) to decrease its DNA binding activity . In addition , treatment of K562 cells with okadaict(interceding-token ngrams: , treatment oft_e2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_with controller:Simple_chemicaltYe2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of >prep_with controllertme1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='casein'] controllert*interceding-token ngrams: binding activityt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controllertle1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] Familytinterceding-token ngrams: CKIIt,interceding-token ngrams: binding activity .t7e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL increasest'e1: ents2Label-mention-ngram: Thr668 byt>e2: ents2Label-mention-ngram: increases SHARED phosphorylationtOe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_with controllert[e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] controlledtJe2: trigger-arg-path: increases >dobj [lemma='phosphorylation'] controlledtinterceding-token ngrams: K562t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controller:Familyt6e1: ents2Label-mention-ngram: phosphorylated at Thr668t interceding-token ngrams: ( CKIItZe2: trigger-arg-path: increases >dobj [lemma='phosphorylation'] controlled:Phosphorylationt)interceding-token ngrams: its DNA bindingt.interceding-token ngrams: DNA binding activityt.interceding-token ngrams: addition , treatmenttfe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of >prep_with controller:Simple_chemicaltinterceding-token ngrams: ) tot&interceding-token ngrams: with okadaictEe2: trigger-arg-path: increases >nsubj >prep_of >prep_with controllertUe2: trigger-arg-path: increases >nsubj >prep_of >prep_with controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] Simple_chemicaltpe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controllert"interceding-token ngrams: ( CKII )tDe2: trigger-arg-path: increases:Positive_regulation >dobj controlledt#interceding-token ngrams: CKII ) tot?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] Simple_chemicalt?e2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controllert$interceding-token ngrams: K562 cellst!interceding-token ngrams: of K562t?e2: trigger-arg-path: increases >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controller:Simple_chemicaltJe1: trigger-arg-path: phosphorylated:Positive_regulation >agent >nn Familyt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controller:Simple_chemicalthe1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] controller:Familytne2: trigger-arg-path: increases:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt]e1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='casein'] Familytee2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj controlled:Phosphorylationt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controllert$e1: ents2Label-mention-ngram: Thr668t?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controllertUe1: trigger-arg-path: phosphorylated:Positive_regulation >agent >nn controller:Familyt#interceding-token ngrams: II ( CKIIt'e1: ents2Label-mention-ngram: by FAMILYt4e1: ents2Label-mention-ngram: is also phosphorylatedtte1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='casein'] controller:Familytwe2: trigger-arg-path: increases >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controllert%interceding-token ngrams: DNA bindingt*e1: ents2Label-mention-ngram: at Thr668 byt0e2: trigger-arg-path: increases >dobj controlledt)interceding-token ngrams: K562 cells withtFe2: trigger-arg-path: lemmatizedTrigger=increase >dobj Phosphorylationt&interceding-token ngrams: treatment oft[e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of >prep_with Simple_chemicalt>e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL increases SHAREDtJe2: trigger-arg-path: increases >nsubj >prep_of >prep_with Simple_chemicalt'interceding-token ngrams: of K562 cellstze2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of >prep_with controller:Simple_chemicaltFe1: trigger-arg-path: Positive_regulation >agent >nn controller:Familyt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent >nn Familytoe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] controlledt!interceding-token ngrams: its DNAtie2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of >prep_with controller:Simple_chemicalt?e2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] Simple_chemicaltje2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of >prep_with controllert'e1: ents2Label-mention-ngram: at Thr668t'interceding-token ngrams: ) to decreaset$interceding-token ngrams: cells witht?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] controller:Simple_chemicaltTe2: trigger-arg-path: increases:Positive_regulation >dobj controlled:Phosphorylationt6e1: trigger-arg-path: phosphorylated >agent >nn Familyt`e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='phosphorylation'] Phosphorylationt/e1: ents2Label-mention-ngram: phosphorylated attVe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of >prep_with controllertRe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent >nn controller:Familyte2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtce2: trigger-arg-path: increases:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationtinterceding-token ngrams: DNAt4e1: ents2Label-mention-ngram: also phosphorylated att interceding-token ngrams: CKII )t@e2: trigger-arg-path: increases >dobj controlled:Phosphorylationt&interceding-token ngrams: decrease itstoe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of >prep_with Simple_chemicalt^e2: trigger-arg-path: increases:Positive_regulation >dobj [lemma='phosphorylation'] controlledtAe1: trigger-arg-path: phosphorylated >agent >nn controller:Familyt'interceding-token ngrams: activity . Int+interceding-token ngrams: treatment of K562t|e2: trigger-arg-path: increases >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >prep_with [lemma='acid'] Simple_chemicaltMe2: trigger-arg-path: Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='Rab'] themet-e1: ents2Label-mention-ngram: SHARED 23 bindstGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] themetMe1: trigger-arg-path: binds >prep_to [lemma='psf'] theme:Gene_or_gene_productt e1: ents2Label-mention-ngram: 23t%e1: args2Role-mention-ngram: 23 bindstOe2: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: 23 binds tot&e1: ents2Label-mention-ngram: 23 bindst&e2: ents2Label-mention-ngram: 23 bindst8e2: trigger-arg-path: binds >prep_to [lemma='psf'] themete1: args2Role-mention-ngram: 23tMe2: trigger-arg-path: binds >prep_to [lemma='psf'] theme:Gene_or_gene_productt e2: ents2Label-mention-ngram: 23tGe1: trigger-arg-path: binds >prep_to [lemma='psf'] Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='Rab'] themetIe1: trigger-arg-path: Binding >prep_to [lemma='psf'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] themet@e2: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] themet+e1: args2Role-mention-ngram: THEME 23 bindstOe1: trigger-arg-path: Binding >prep_to [lemma='psf'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: THEME 23t:e1: trigger-arg-path: Binding >prep_to [lemma='psf'] themet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] Gene_or_gene_producttKe2: trigger-arg-path: binds >nsubj [lemma='Rab'] theme:Gene_or_gene_productte2: args2Role-mention-ngram: 23tSe2: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: 23 binds tot)e1: ents2Label-mention-ngram: 23 binds totQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] themet%e1: args2Role-mention-ngram: THEME 23tGe2: trigger-arg-path: binds >prep_to [lemma='psf'] Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: SHARED 23tOe2: trigger-arg-path: Binding >prep_to [lemma='psf'] theme:Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] themetUe2: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] theme:Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='Rab'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: 23 binds totfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='Rab'] Gene_or_gene_productt:e2: trigger-arg-path: Binding >prep_to [lemma='psf'] themetIe2: trigger-arg-path: Binding >prep_to [lemma='psf'] Gene_or_gene_productt8e1: trigger-arg-path: binds >prep_to [lemma='psf'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] themet-e2: ents2Label-mention-ngram: SHARED 23 bindstIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='psf'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED 23t^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >prep_to [lemma='psf'] Gene_or_gene_productt+e2: args2Role-mention-ngram: THEME 23 bindst^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] theme:Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding >nsubj [lemma='Rab'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Rab'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: 23 bindstXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Rab'] themetXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='psf'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] theme:Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding >nn [lemma='tsc'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='tsc'] theme:Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='tsc'] Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] themetJe1: trigger-arg-path: complex >nn [lemma='tsc'] theme:Gene_or_gene_producttKe1: trigger-arg-path: complex >nn [lemma='tsc1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >nn [lemma='tsc'] theme:Gene_or_gene_productt6e1: trigger-arg-path: Binding >nn [lemma='tsc1'] themetDe1: trigger-arg-path: Binding >nn [lemma='tsc'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='tsc1'] theme:Gene_or_gene_productt=e1: trigger-arg-path: complex:Binding >nn [lemma='tsc'] themetOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] themet_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] Gene_or_gene_producttEe1: trigger-arg-path: complex >nn [lemma='tsc1'] Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='tsc'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='tsc'] themetDe2: trigger-arg-path: Binding >nn [lemma='tsc'] Gene_or_gene_producttMe1: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] themetWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] Gene_or_gene_productt5e1: trigger-arg-path: Binding >nn [lemma='tsc'] themet6e1: trigger-arg-path: complex >nn [lemma='tsc1'] themetOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] themetEe1: trigger-arg-path: Binding >nn [lemma='tsc1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] Gene_or_gene_productt5e1: trigger-arg-path: complex >nn [lemma='tsc'] themet]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: complex:Binding >nn [lemma='tsc'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] themetPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc1'] themetSe1: trigger-arg-path: complex:Binding >nn [lemma='tsc1'] theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='tsc'] themet5e2: trigger-arg-path: complex >nn [lemma='tsc'] themetLe1: trigger-arg-path: complex:Binding >nn [lemma='tsc'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] theme:Gene_or_gene_producttDe1: trigger-arg-path: complex >nn [lemma='tsc'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='tsc'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc'] Gene_or_gene_productt#interceding-token ngrams: other Raftre2: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='raf'] controllertPe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='b-raf'] controlledtOe1: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='b-raf'] controlledt/e1: args2Role-mention-ngram: CONTROLLER and MEKtJe1: ents2Label-mention-ngram: allosterically inhibits GENE_OR_GENE_PRODUCTt]e1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='b-raf'] Gene_or_gene_productt:e1: trigger-arg-path: inhibits dobj [lemma='b-raf'] Gene_or_gene_productt?e1: args2Role-mention-ngram: allosterically inhibits CONTROLLEDt?e1: trigger-arg-path: inhibits >dobj [lemma='b-raf'] controlledtAe1: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='b-raf'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: MEK inhibitort?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='raf'] Gene_or_gene_producttRe1: trigger-arg-path: inhibits:Negative_activation prep_by [lemma='raf'] Gene_or_gene_productt+interceding-token ngrams: Raf inhibitors astje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation prep_by [lemma='raf'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: allostericallyt*interceding-token ngrams: a different modet'interceding-token ngrams: Raf-1 and MEKt?interceding-tokens-full-span: , Raf-1 and MEK . RO5126766 has a different mode of action than other Raf inhibitors as binds MEK and suppresses thet:e1: args2Role-mention-ngram: which allosterically inhibitstde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='b-raf'] controlledtJe1: trigger-arg-path: Negative_activation >dobj [lemma='b-raf'] controlledtxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='raf'] controllert)interceding-token ngrams: . RO5126766 hastje2: trigger-arg-path: phosphorylation prep_by [lemma='raf'] Gene_or_gene_producttinterceding-token ngrams: Raf-1t#interceding-token ngrams: and MEK .tue2: trigger-arg-path: phosphorylation prep_by [lemma='raf'] controller:Gene_or_gene_producttdobj [lemma='b-raf'] Gene_or_gene_productt^e1: trigger-arg-path: Negative_activation dobj [lemma='b-raf'] controlled:Gene_or_gene_producttMe1: trigger-arg-path: inhibits:Negative_activation >dobj Gene_or_gene_productt e1: args2Role-mention-ngram: MEKt-e1: ents2Label-mention-ngram: inhibitor whicht!interceding-token ngrams: mode oft8e2: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT byt'interceding-token ngrams: RO5126766 hast%e1: ents2Label-mention-ngram: and MEKtprep_by [lemma='raf'] controller:Gene_or_gene_productt,interceding-token ngrams: and suppresses thetye2: trigger-arg-path: Positive_regulation prep_by [lemma='raf'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: MEK inhibitorthe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='b-raf'] controlled:Gene_or_gene_productt-interceding-token ngrams: inhibitors as bindst(interceding-token ngrams: different modette2: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='raf'] controllertDe1: trigger-arg-path: inhibits >dobj controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='raf'] controller:Gene_or_gene_productt9e1: trigger-arg-path: inhibits >dobj Gene_or_gene_producttDe1: trigger-arg-path: inhibits:Negative_activation prep_by [lemma='raf'] controllertye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='b-raf'] controlled:Gene_or_gene_productt#interceding-token ngrams: binds MEKtUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj [lemma='b-raf'] controlled:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=inhibit prep_by [lemma='raf'] controllert>e1: trigger-arg-path: inhibits dobj [lemma='b-raf'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation prep_by [lemma='raf'] Gene_or_gene_productt_e1: trigger-arg-path: Negative_activation >dobj [lemma='b-raf'] controlled:Gene_or_gene_productt1e1: ents2Label-mention-ngram: MEK inhibitor whicht'interceding-token ngrams: inhibitors astSe1: trigger-arg-path: Negative_activation prep_by [lemma='raf'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: which allosterically inhibitst_e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation rcmod ++ ROOT >advcl >dobjt;e1: trigger-arg-path: Negative_activation dobj controlledt(interceding-token ngrams: Raf inhibitorstLe2: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] themet_e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: and SHARED bindingtLe1: trigger-arg-path: Binding >nn [lemma='keap1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='pkc'] controllertnsubj controller:Gene_or_gene_productt~e2: trigger-arg-path: Positive_regulation nsubj [lemma='pkc'] controller:Gene_or_gene_producttDinterceding-tokens-full-span: and therefore inhibits Nrf2 activity .t5e2: ents2Label-mention-ngram: directly phosphorylatestXe2: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_producttAe2: trigger-arg-path: Positive_regulation nn [lemma='nrf2'] Gene_or_gene_producttEe2: trigger-arg-path: directly:Positive_regulation nsubj [lemma='pkc'] Gene_or_gene_producttnn [lemma='nrf2'] Gene_or_gene_producttFe1: trigger-arg-path: binding >nn [lemma='keap1'] Gene_or_gene_producttJe2: trigger-arg-path: directly:Positive_regulation nsubj controller:Gene_or_gene_producttLe2: trigger-arg-path: directly:Positive_regulation nsubj controllert1interceding-token ngrams: therefore inhibits Nrf2tTe1: trigger-arg-path: binding:Binding >nn [lemma='keap1'] theme:Gene_or_gene_productt'interceding-token ngrams: Nrf2 activitytNe2: trigger-arg-path: directly nn [lemma='keap1'] Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding >nn [lemma='keap1'] themetYe2: trigger-arg-path: Positive_regulation nsubj Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj Gene_or_gene_producttie2: trigger-arg-path: Positive_regulation nsubj [lemma='pkc'] controllert7e1: trigger-arg-path: binding >nn [lemma='keap1'] themetse2: trigger-arg-path: directly nsubj [lemma='pkc'] controller:Gene_or_gene_producttNe1: trigger-arg-path: binding:Binding >nn [lemma='keap1'] Gene_or_gene_producttCe2: trigger-arg-path: Positive_regulation nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='pkc'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=directly nn [lemma='nrf2'] theme:Gene_or_gene_productt0interceding-token ngrams: inhibits Nrf2 activitytee1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj controllert?e2: trigger-arg-path: directly:Positive_regulation nsubj [lemma='pkc'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=directly nsubj controllert2CSSPATH: ROOT >prepc_on >dep >dobj ++ ROOT >advmodtre2: trigger-arg-path: directly:Positive_regulation nsubj [lemma='pkc'] controllert;e2: args2Role-mention-ngram: CONTROLLER directly CONTROLLEDtEe1: trigger-arg-path: Binding >nn [lemma='nrf2'] Gene_or_gene_productt6e1: trigger-arg-path: Binding >nn [lemma='nrf2'] themethe2: trigger-arg-path: directly nsubj [lemma='pkc'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='nrf2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] Gene_or_gene_producttLe1: trigger-arg-path: binding >nn [lemma='keap1'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: and THEME bindingtIe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] themet1e2: trigger-arg-path: directly nn [lemma='nrf2'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binding:Binding >nn [lemma='nrf2'] themetTe2: trigger-arg-path: Positive_regulation nsubj controller:Gene_or_gene_productt8e2: trigger-arg-path: directly nsubj controllert,interceding-token ngrams: therefore inhibitstQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='keap1'] themetde2: trigger-arg-path: Positive_regulation nn [lemma='keap1'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='keap1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=directly nsubj Gene_or_gene_producttIe2: trigger-arg-path: directly nsubj [lemma='pkc'] Gene_or_gene_producttAe2: trigger-arg-path: directly nsubj Gene_or_gene_productt|e2: trigger-arg-path: directly:Positive_regulation nsubj [lemma='pkc'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=directly nsubj [lemma='pkc'] controller:Gene_or_gene_productt'interceding-token ngrams: inhibits Nrf2t?e2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nsubj [lemma='pkc'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=directly nsubj [lemma='pkc'] controllert0interceding-token ngrams: and therefore inhibitst)interceding-token ngrams: Nrf2 activity .tJe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT directly phosphorylatest;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT directlyt7e1: trigger-arg-path: Binding >nn [lemma='keap1'] themetHe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='nrf2'] themet`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='keap1'] Gene_or_gene_productt^e2: trigger-arg-path: directly nsubj [lemma='pkc'] controllertbe2: trigger-arg-path: directly:Positive_regulation nn [lemma='nrf2'] Gene_or_gene_productt6e1: trigger-arg-path: binding >nn [lemma='nrf2'] themetCe2: trigger-arg-path: lemmatizedTrigger=directly nsubj Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=directly:Positive_regulation nn [lemma='nrf2'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=activate >agent >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: activity byt(interceding-token ngrams: survival undert^e1: trigger-arg-path: activated >agent [lemma='phosphorylation'] >nn [lemma='perk'] controllert1e2: args2Role-mention-ngram: Neh6 domain inhibitst,e2: ents2Label-mention-ngram: of Neh6 domaint)e2: args2Role-mention-ngram: its activitytre1: trigger-arg-path: Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] Gene_or_gene_productt+e2: args2Role-mention-ngram: of Neh6 domaint2e2: args2Role-mention-ngram: activity by promotingt,e1: ents2Label-mention-ngram: also activatedt?e1: ents2Label-mention-ngram: activated by GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: activated >nsubjpass Gene_or_gene_producttXe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='nrf2'] controlledt/e1: ents2Label-mention-ngram: is also activatedt"interceding-token ngrams: stress .t,interceding-token ngrams: reticulum stress .tDe2: args2Role-mention-ngram: promoting beta-TrCP-mediated CONTROLLEDt2e2: args2Role-mention-ngram: inhibits its activityt[e1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass controlled:Gene_or_gene_producttIe2: ents2Label-mention-ngram: promoting beta-TrCP-mediated ubiquitinationt?e1: trigger-arg-path: Positive_activation >agent >nn controllertIe1: trigger-arg-path: Positive_activation >agent >nn Gene_or_gene_producttagent [lemma='phosphorylation'] >nn [lemma='perk'] controller:Gene_or_gene_productt4interceding-token ngrams: survival under endoplasmict-e2: ents2Label-mention-ngram: domain inhibitstJe1: trigger-arg-path: activated >nsubjpass controlled:Gene_or_gene_productt6interceding-token ngrams: phosphorylation and promotest/interceding-token ngrams: endoplasmic reticulumt?e2: ents2Label-mention-ngram: beta-TrCP-mediated ubiquitinationt5interceding-token ngrams: under endoplasmic reticulumtme1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='nrf2'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: activated >agent >nn controller:Gene_or_gene_producttSe1: trigger-arg-path: activated:Positive_activation >nsubjpass Gene_or_gene_productt#interceding-token ngrams: reticulumtye1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='phosphorylation'] >nn [lemma='perk'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='phosphorylation'] >nn [lemma='perk'] controllert3interceding-token ngrams: dependent phosphorylationt[e1: trigger-arg-path: lemmatizedTrigger=activate >agent >nn controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: also activated byt~e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='nrf2'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: Neh6 domaint'interceding-token ngrams: promotes cellt(e2: args2Role-mention-ngram: activity byt6interceding-token ngrams: endoplasmic reticulum stresst2e2: ents2Label-mention-ngram: Neh6 domain inhibitst0e2: ents2Label-mention-ngram: serine residues oftIe1: trigger-arg-path: activated:Positive_activation >agent >nn controllert-interceding-token ngrams: cell survival undert,e2: args2Role-mention-ngram: domain inhibitstre1: trigger-arg-path: activated:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] controllertde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLED is alsot?interceding-tokens-full-span: dependent phosphorylation and promotes cell survival under endoplasmic reticulum stress . In contrast ,t^e1: trigger-arg-path: activated:Positive_activation >agent >nn controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: by GENE_OR_GENE_PRODUCT att(e2: args2Role-mention-ngram: Neh6 domaint'interceding-token ngrams: In contrast ,t:e2: args2Role-mention-ngram: beta-TrCP-mediated CONTROLLEDt:e2: ents2Label-mention-ngram: promoting beta-TrCP-mediatedt?e1: trigger-arg-path: Positive_activation >nsubjpass controlledtce1: trigger-arg-path: Positive_activation >nsubjpass [lemma='nrf2'] controlled:Gene_or_gene_productt%interceding-token ngrams: endoplasmict^e1: trigger-arg-path: activated:Positive_activation >nsubjpass controlled:Gene_or_gene_producttNe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='nrf2'] controlledt|e1: trigger-arg-path: activated:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] Gene_or_gene_producttbe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='nrf2'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: domain inhibits itstXe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='nrf2'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: of Neh6tYe1: trigger-arg-path: activated >nsubjpass [lemma='nrf2'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: activated >agent >nn Gene_or_gene_producttIe1: trigger-arg-path: activated:Positive_activation >nsubjpass controlledt7interceding-token ngrams: dependent phosphorylation andtPe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass Gene_or_gene_productt'interceding-token ngrams: cell survivalt.e2: ents2Label-mention-ngram: residues of Neh6t*e2: ents2Label-mention-ngram: by promotingt&interceding-token ngrams: and promotestoe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn controllert3e2: ents2Label-mention-ngram: inhibits its activityt%interceding-token ngrams: In contrastthe1: trigger-arg-path: activated >agent [lemma='phosphorylation'] >nn [lemma='perk'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='nrf2'] Gene_or_gene_productt!e2: args2Role-mention-ngram: Neh6t-e2: ents2Label-mention-ngram: its activity byt0interceding-token ngrams: promotes cell survivaltoe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass controlled:Gene_or_gene_productt*e1: args2Role-mention-ngram: CONTROLLED ist?e1: trigger-arg-path: activated:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLER of Neh6tIe1: trigger-arg-path: Positive_activation >nsubjpass Gene_or_gene_producttNe1: trigger-arg-path: activated >nsubjpass [lemma='nrf2'] Gene_or_gene_productt'interceding-token ngrams: . In contrastt.e1: args2Role-mention-ngram: is also activatedt+interceding-token ngrams: under endoplasmicthe1: trigger-arg-path: Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] controllert3e2: ents2Label-mention-ngram: activity by promotingt*e2: ents2Label-mention-ngram: its activitytZe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass controlledt,e2: args2Role-mention-ngram: its activity byt=e2: ents2Label-mention-ngram: by promoting beta-TrCP-mediatedt/e1: ents2Label-mention-ngram: also activated bytse1: trigger-arg-path: activated >agent [lemma='phosphorylation'] >nn [lemma='perk'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: beta-TrCP-mediatedt5e1: trigger-arg-path: activated >agent >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='phosphorylation'] >nn [lemma='perk'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: also activatedt)e2: args2Role-mention-ngram: by promotingt+interceding-token ngrams: and promotes celltje1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='nrf2'] controlled:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass controlledtie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='nrf2'] controlledtFe1: trigger-arg-path: lemmatizedTrigger=activate >agent >nn controllert0e2: args2Role-mention-ngram: domain inhibits itstde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass Gene_or_gene_productt%interceding-token ngrams: stress . Int9e2: args2Role-mention-ngram: promoting beta-TrCP-mediatedt0e2: ents2Label-mention-ngram: beta-TrCP-mediatedt-interceding-token ngrams: phosphorylation andtSe1: trigger-arg-path: activated:Positive_activation >agent >nn Gene_or_gene_productt-e2: ents2Label-mention-ngram: serine residuestTe1: trigger-arg-path: Positive_activation >nsubjpass controlled:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='nrf2'] Gene_or_gene_productt*interceding-token ngrams: reticulum stresst"interceding-token ngrams: survivaltTe1: trigger-arg-path: Positive_activation >agent >nn controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: of Neh6tUe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='nrf2'] controlledtnsubjpass controlledt0e2: ents2Label-mention-ngram: at serine residuest?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='phosphorylation'] >nn [lemma='perk'] controllertCe2: ents2Label-mention-ngram: beta-TrCP-mediated ubiquitination andtDe1: trigger-arg-path: activated >nsubjpass [lemma='nrf2'] controlledt"e2: ents2Label-mention-ngram: Neh6t1interceding-token ngrams: MST2 constitutively andt)interceding-token ngrams: of cancer cellst"interceding-token ngrams: cells byt#interceding-token ngrams: and seemst^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='mst2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='mst2'] theme:Gene_or_gene_productt#interceding-token ngrams: of cancertGe2: trigger-arg-path: Binding >dobj [lemma='mst2'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='B-Raf'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='mst2'] theme:Gene_or_gene_producttinterceding-token ngrams: MST2t:e2: trigger-arg-path: Binding >nsubj [lemma='B-Raf'] themetMe2: trigger-arg-path: binds >nsubj [lemma='B-Raf'] theme:Gene_or_gene_producttinterceding-token ngrams: A-Raft&interceding-token ngrams: the survivalt(interceding-token ngrams: by restrainingt-interceding-token ngrams: by restraining MST2tXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='B-Raf'] Gene_or_gene_productt%interceding-token ngrams: A-Raf bindstVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='mst2'] Gene_or_gene_productt0interceding-token ngrams: to MST2 constitutivelyt'interceding-token ngrams: MST2 mediatedt*interceding-token ngrams: restraining MST2tMe2: trigger-arg-path: Binding >dobj [lemma='mst2'] theme:Gene_or_gene_productt>e2: trigger-arg-path: binds:Binding >dobj [lemma='mst2'] themetOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='mst2'] themet,interceding-token ngrams: mediated apoptosist%interceding-token ngrams: promote thet8e2: trigger-arg-path: Binding >dobj [lemma='mst2'] themet,interceding-token ngrams: constitutively andtOe2: trigger-arg-path: binds:Binding >nsubj [lemma='B-Raf'] Gene_or_gene_productt%interceding-token ngrams: survival oft!interceding-token ngrams: to MST2tOe2: trigger-arg-path: Binding >nsubj [lemma='B-Raf'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='mst2'] themet*interceding-token ngrams: mitogens , A-RaftUe2: trigger-arg-path: binds:Binding >nsubj [lemma='B-Raf'] theme:Gene_or_gene_productt)interceding-token ngrams: cancer cells byt!interceding-token ngrams: , A-Raft?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds SHAREDt6e2: trigger-arg-path: binds >dobj [lemma='mst2'] themet!interceding-token ngrams: promotet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='B-Raf'] Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >dobj [lemma='mst2'] Gene_or_gene_productt.interceding-token ngrams: cells by restrainingt'interceding-token ngrams: , A-Raf bindstfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='B-Raf'] theme:Gene_or_gene_productt.interceding-token ngrams: promote the survivalt2interceding-token ngrams: constitutively and seemstKe2: trigger-arg-path: binds >dobj [lemma='mst2'] theme:Gene_or_gene_productt(interceding-token ngrams: to promote thet(interceding-token ngrams: A-Raf binds tot@e2: trigger-arg-path: binds:Binding >nsubj [lemma='B-Raf'] themet'interceding-token ngrams: binds to MST2tIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='B-Raf'] themetSe2: trigger-arg-path: binds:Binding >dobj [lemma='mst2'] theme:Gene_or_gene_producttGe2: trigger-arg-path: binds >nsubj [lemma='B-Raf'] Gene_or_gene_productt*interceding-token ngrams: seems to promotet(CSSPATH: ROOT >advcl >nsubjpass ++ ROOT t%interceding-token ngrams: restrainingt8e2: trigger-arg-path: binds >nsubj [lemma='B-Raf'] themet1interceding-token ngrams: MST2 mediated apoptosist%interceding-token ngrams: apoptosis .tinterceding-token ngrams: seemst3interceding-token ngrams: restraining MST2 mediatedt,interceding-token ngrams: survival of cancertQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='B-Raf'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='B-Raf'] theme:Gene_or_gene_productt.interceding-token ngrams: mediated apoptosis .t?interceding-tokens-full-span: is induced by stress and reduced by mitogens , A-Raf binds to MST2 constitutively and seems to promote the survival of cancer cells by restraining MST2 mediated apoptosis .t"interceding-token ngrams: seems tot)interceding-token ngrams: the survival oft-interceding-token ngrams: MST2 constitutivelytEe2: trigger-arg-path: binds >dobj [lemma='mst2'] Gene_or_gene_productt(interceding-token ngrams: constitutivelyt&interceding-token ngrams: and seems tot$interceding-token ngrams: to promotetbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttOe2: trigger-arg-path: interact >prep_with [lemma='mtorc1'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] Gene_or_gene_producttXe2: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] themet?e1: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] themetbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] themet@e2: trigger-arg-path: interact >prep_with [lemma='mtorc1'] themetIe1: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] Gene_or_gene_productt;e2: trigger-arg-path: interact >nsubj [lemma='GSK-3'] themet-e1: ents2Label-mention-ngram: SHARED can alsotae2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] themetHe1: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] themetTe1: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] themetMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] themetoe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_productt;e1: trigger-arg-path: interact >nsubj [lemma='GSK-3'] themetRe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] themetge2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] theme:Gene_or_gene_productt]e1: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='mtorc1'] Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] themetRe1: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_productt@e1: trigger-arg-path: interact >prep_with [lemma='mtorc1'] themetCe1: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] themetge1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttWe1: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] Gene_or_gene_producttOe2: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_productt]e2: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME can alsotPe2: trigger-arg-path: interact >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] Gene_or_gene_producttCe2: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] themet\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] Gene_or_gene_producttPe1: trigger-arg-path: interact >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] themet:e2: trigger-arg-path: Binding >nsubj [lemma='GSK-3'] themetJe2: trigger-arg-path: interact >nsubj [lemma='GSK-3'] Gene_or_gene_producttWe2: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] Gene_or_gene_producttUe1: trigger-arg-path: interact >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='mtorc1'] themetUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='GSK-3'] themetNe1: trigger-arg-path: Binding >prep_with [lemma='mtorc1'] Gene_or_gene_producttRe2: trigger-arg-path: interact:Binding >nsubj [lemma='GSK-3'] Gene_or_gene_producttUe2: trigger-arg-path: interact >prep_with [lemma='mtorc1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interact >nsubj [lemma='GSK-3'] Gene_or_gene_producttHe2: trigger-arg-path: interact:Binding >prep_with [lemma='mtorc1'] themetOe1: trigger-arg-path: interact >prep_with [lemma='mtorc1'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] Familyt*interceding-token ngrams: of several genestQe1: trigger-arg-path: Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] themetMe2: trigger-arg-path: Binding nn [lemma='e7'] FamilytXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='prb'] Gene_or_gene_productt,interceding-token ngrams: cell proliferationt{e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='e7'] Familyt-e1: trigger-arg-path: binds >nsubj >nn FamilytTe2: trigger-arg-path: complex:Binding nn [lemma='e7'] themetMe2: trigger-arg-path: complex nn [lemma='e7'] Familyt)interceding-token ngrams: proliferation .tXe1: trigger-arg-path: binds:Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] Familyt9e2: trigger-arg-path: complex:Binding nsubj >nn theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_to [lemma='prb'] Gene_or_gene_producttFe2: trigger-arg-path: Binding nsubj [lemma='oncoprotein'] >nn [lemma='e7'] Familyt$interceding-token ngrams: of severalt!interceding-token ngrams: the pRbt4interceding-token ngrams: transcriptional activationtRe2: trigger-arg-path: complex prep_to [lemma='prb'] themet%interceding-token ngrams: genes whichtIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='prb'] themet.interceding-token ngrams: cell proliferation .tfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='e7'] themetGe1: trigger-arg-path: binds >prep_to [lemma='prb'] Gene_or_gene_producttNe2: trigger-arg-path: complex:Binding nsubj [lemma='oncoprotein'] >nn [lemma='e7'] theme:Familyt"interceding-token ngrams: E2F fromt&interceding-token ngrams: E2F from thetinterceding-token ngrams: E2Ft$interceding-token ngrams: factor E2Ft%interceding-token ngrams: pRb and E2FtIe1: trigger-arg-path: Binding >prep_to [lemma='prb'] Gene_or_gene_producttOe1: trigger-arg-path: binds >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] themetVe1: trigger-arg-path: binds >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] theme:Familyt@e2: trigger-arg-path: Binding prep_to [lemma='prb'] theme:Gene_or_gene_productt8e1: trigger-arg-path: binds >prep_to [lemma='prb'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] FamilytSe2: trigger-arg-path: complex nn [lemma='e7'] theme:Familyt&interceding-token ngrams: dissociatingt%interceding-token ngrams: E2F complextQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='prb'] themet?interceding-tokens-full-span: dissociating the transcription factor E2F from the pRb and E2F complex , resulting in the transcriptional activation of several genes which facilitate cell proliferation .t6e1: ents2Label-mention-ngram: SHARED oncoprotein bindstee2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='e7'] theme:Familyt_e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='e7'] Familyt`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] themetWe1: trigger-arg-path: binds:Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] themet.e1: args2Role-mention-ngram: THEME oncoproteintRe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='e7'] themetoe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] theme:Familyt'interceding-token ngrams: several genestse2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='e7'] theme:Familyt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='prb'] theme:Gene_or_gene_productt5e1: trigger-arg-path: binds:Binding >nsubj >nn Familyt^e1: trigger-arg-path: binds:Binding >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] theme:FamilytKe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj [lemma='oncoprotein'] >nn [lemma='e7'] theme:FamilytSe2: trigger-arg-path: Binding nn [lemma='e7'] theme:Familytinterceding-token ngrams: pRbt3e1: trigger-arg-path: binds >nsubj >nn theme:Familyt-interceding-token ngrams: several genes whicht!CSSPATH: ROOT  ++ ROOT >nsubj >nntUe2: trigger-arg-path: complex:Binding nn [lemma='e7'] FamilytPe1: trigger-arg-path: binds >nsubj [lemma='oncoprotein'] >nn [lemma='e7'] FamilytMe1: trigger-arg-path: binds >prep_to [lemma='prb'] theme:Gene_or_gene_productt@e2: trigger-arg-path: complex nn [lemma='e7'] themet4e1: args2Role-mention-ngram: THEME oncoprotein bindstye2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='e7'] theme:Familyt0interceding-token ngrams: genes which facilitatetLe2: trigger-arg-path: Binding nn [lemma='e7'] themetUe1: trigger-arg-path: binds:Binding >prep_to [lemma='prb'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: oncoprotein bindstOe1: trigger-arg-path: Binding >prep_to [lemma='prb'] theme:Gene_or_gene_productt&interceding-token ngrams: from the pRbtFe2: trigger-arg-path: complex prep_to [lemma='prb'] themet0e1: ents2Label-mention-ngram: SHARED oncoproteint`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj [lemma='oncoprotein'] >nn [lemma='e7'] themetde2: trigger-arg-path: lemmatizedTrigger=complex prep_to [lemma='prb'] Gene_or_gene_productt)interceding-token ngrams: and E2F complext-interceding-token ngrams: complex , resultingt'e2: args2Role-mention-ngram: suppressortae1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: suppressor THEMEt'interceding-token ngrams: to affect thetLe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] themetLe1: trigger-arg-path: complex:Binding >nn [lemma='ksr'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: other tumor suppressortbe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] Gene_or_gene_producttWe2: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttDe1: trigger-arg-path: complex >nn [lemma='ksr'] Gene_or_gene_productt#interceding-token ngrams: explore .tJe1: trigger-arg-path: Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttQe1: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] Gene_or_gene_producttJe2: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] themetBe1: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] themetje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] Gene_or_gene_producttWe1: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] themet$interceding-token ngrams: affect thet(interceding-token ngrams: affect the MEKt[e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttYe2: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] Gene_or_gene_productt=e1: trigger-arg-path: complex:Binding >nn [lemma='ksr'] themet-e2: args2Role-mention-ngram: tumor suppressortDe1: trigger-arg-path: Binding >nn [lemma='ksr'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: other tumortOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] themet/interceding-token ngrams: ERK signaling pathwayt+interceding-token ngrams: and ERK signalingt5e1: trigger-arg-path: Binding >nn [lemma='ksr'] themetpinterceding-tokens-full-span: to affect the MEK and ERK signaling pathway is valuable to explore . In addition ,tJe1: trigger-arg-path: complex >nn [lemma='ksr'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt=e2: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] themet&interceding-token ngrams: to explore .t$interceding-token ngrams: pathway ist?e2: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] themetTe2: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] themetIe1: trigger-arg-path: Binding >nn [lemma='aurora-a'] Gene_or_gene_productt!interceding-token ngrams: the MEKt"e2: args2Role-mention-ngram: tumortOe2: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] themet\e2: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: with the othert+e2: args2Role-mention-ngram: with the othert.interceding-token ngrams: signaling pathway istNe2: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] Gene_or_gene_productt#interceding-token ngrams: to affectt3e2: args2Role-mention-ngram: other tumor suppressort!interceding-token ngrams: exploret(e2: args2Role-mention-ngram: other tumort-interceding-token ngrams: valuable to exploret5e1: trigger-arg-path: complex >nn [lemma='ksr'] themetBe2: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] themet=e2: ents2Label-mention-ngram: suppressor GENE_OR_GENE_PRODUCTt&e2: args2Role-mention-ngram: the othert/e2: args2Role-mention-ngram: interacts with thet@e2: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] themetCe2: ents2Label-mention-ngram: tumor suppressor GENE_OR_GENE_PRODUCTt-e2: ents2Label-mention-ngram: the other tumortRe1: trigger-arg-path: complex:Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] themetIe1: trigger-arg-path: complex >nn [lemma='aurora-a'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: the othert_e2: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] Gene_or_gene_productt%interceding-token ngrams: valuable tot:e1: trigger-arg-path: Binding >nn [lemma='aurora-a'] themet_e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] Gene_or_gene_producttGe2: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] themetXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] themetie1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: interacts with thet:e1: trigger-arg-path: complex >nn [lemma='aurora-a'] themet interceding-token ngrams: affectt&interceding-token ngrams: explore . Int"interceding-token ngrams: valuablet,e2: args2Role-mention-ngram: the other tumort(interceding-token ngrams: is valuable totOe1: trigger-arg-path: complex >nn [lemma='aurora-a'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_productt#CSSPATH: ROOT >csubj >dobj ++ ROOT t\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] theme:Gene_or_gene_productt%interceding-token ngrams: the MEK andt$interceding-token ngrams: to exploret%interceding-token ngrams: MEK and ERKt+interceding-token ngrams: signaling pathwaytTe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] themet!interceding-token ngrams: and ERKtpe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_productt3e2: args2Role-mention-ngram: tumor suppressor THEMEt-interceding-token ngrams: pathway is valuablet'interceding-token ngrams: ERK signalingtme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt%interceding-token ngrams: is valuabletQe2: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] Gene_or_gene_producttee1: trigger-arg-path: associates:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] themet2e1: ents2Label-mention-ngram: autophagy initiatingtCSSPATH: ROOT  ++ ROOT >nsubjt?e1: trigger-arg-path: lemmatizedTrigger=associate >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='AMPK'] themet0e1: args2Role-mention-ngram: associates with andt9e1: args2Role-mention-ngram: phosphorylates the autophagytle1: trigger-arg-path: associates >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] Gene_or_gene_productt\e2: trigger-arg-path: Positive_regulation >nn [lemma='ampk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ampk'] controllertze1: trigger-arg-path: associates:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='AMPK'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: kinase THEMEt>e1: trigger-arg-path: associates:Binding >conj_and >dobj themetGe1: trigger-arg-path: lemmatizedTrigger=associate >conj_and >dobj themetDe1: trigger-arg-path: associates:Binding >nsubj [lemma='AMPK'] themetie1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: autophagy initiatingtte1: trigger-arg-path: associates:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] Gene_or_gene_productt3e1: args2Role-mention-ngram: and phosphorylates thetMe2: trigger-arg-path: phosphorylation >nn [lemma='ampk'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] themet\e1: trigger-arg-path: lemmatizedTrigger=associate >conj_and >dobj theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and >dobj theme:Gene_or_gene_producttKe1: trigger-arg-path: associates >nsubj [lemma='AMPK'] Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='AMPK'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: and phosphorylates thetSe1: trigger-arg-path: associates:Binding >conj_and >dobj theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED associates withtje2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ampk'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: the autophagytbe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='AMPK'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and >dobj Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and >dobj themetQe1: trigger-arg-path: associates >nsubj [lemma='AMPK'] theme:Gene_or_gene_producttnsubj [lemma='AMPK'] themet/e1: ents2Label-mention-ngram: SHARED associatest:e1: ents2Label-mention-ngram: phosphorylates the autophagyt?e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] Gene_or_gene_productt4e1: args2Role-mention-ngram: initiating kinase THEMEt\e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='AMPK'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ampk'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='AMPK'] Gene_or_gene_producttSe1: trigger-arg-path: associates:Binding >nsubj [lemma='AMPK'] Gene_or_gene_producttMe1: trigger-arg-path: associates:Binding >conj_and >dobj Gene_or_gene_productt6e1: ents2Label-mention-ngram: the autophagy initiatingtQe2: trigger-arg-path: Positive_regulation >nn [lemma='ampk'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ampk'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=associate >conj_and >dobj Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=associate >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] Gene_or_gene_producttEe1: trigger-arg-path: associates >conj_and >dobj Gene_or_gene_productt9e1: ents2Label-mention-ngram: autophagy initiating kinasetUe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='ampk'] controllertCe2: trigger-arg-path: phosphorylation >nn [lemma='ampk'] controllertae2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ampk'] Gene_or_gene_productt8e1: args2Role-mention-ngram: autophagy initiating kinasetYe1: trigger-arg-path: associates:Binding >nsubj [lemma='AMPK'] theme:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='AMPK'] theme:Gene_or_gene_producttWe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ampk'] controllert5e1: args2Role-mention-ngram: the autophagy initiatingt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='ampk'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: associates with andtne1: trigger-arg-path: lemmatizedTrigger=associate >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] themetoe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: THEME associates witht>e2: ents2Label-mention-ngram: SHARED dependent phosphorylationt/e1: args2Role-mention-ngram: phosphorylates thetGe2: trigger-arg-path: Positive_regulation >nn [lemma='ampk'] controllertle2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='ampk'] controller:Gene_or_gene_productt6e1: trigger-arg-path: associates >conj_and >dobj themetMe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='AMPK'] themet]e1: trigger-arg-path: associates >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] themet+e1: ents2Label-mention-ngram: the autophagytre1: trigger-arg-path: associates >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='AMPK'] themet-e1: args2Role-mention-ngram: THEME associatestKe1: trigger-arg-path: associates >conj_and >dobj theme:Gene_or_gene_producttXe2: trigger-arg-path: phosphorylation >nn [lemma='ampk'] controller:Gene_or_gene_producttZe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='ulk1'] themet(interceding-token ngrams: HMGA2 leads totHe1: trigger-arg-path: requires:Positive_regulation >dobj Phosphorylationt)interceding-token ngrams: the interactiont9e1: ents2Label-mention-ngram: interaction requires SHAREDt$interceding-token ngrams: downstreamtXe2: trigger-arg-path: degradation:Negative_activation >nn [lemma='ubiquitin'] controllert?e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] Gene_or_gene_producttCe2: trigger-arg-path: degradation >prep_of >nn Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='protein'] >nn [lemma='pml'] controlledtVe2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn controllert5e2: args2Role-mention-ngram: dependent degradation oftBe2: trigger-arg-path: Negative_activation >nn Gene_or_gene_productt3e1: trigger-arg-path: requires >nsubj Generic_eventtse1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt6e2: args2Role-mention-ngram: degradation of CONTROLLEDtKe2: trigger-arg-path: Negative_activation >prep_of >nn Gene_or_gene_productt*interceding-token ngrams: interaction , ast3interceding-token ngrams: mediating the interactiont#interceding-token ngrams: unknown .t2e2: args2Role-mention-ngram: dependent degradationt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='interaction'] controller:Generic_eventtIe1: trigger-arg-path: Positive_regulation >nsubj controller:Generic_eventtVe2: trigger-arg-path: lemmatizedTrigger=degradation >nn [lemma='ubiquitin'] controllert1interceding-token ngrams: the kinases responsibletne2: trigger-arg-path: degradation >prep_of [lemma='protein'] >nn [lemma='pml'] controlled:Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=degradation >nn controllert;e1: args2Role-mention-ngram: CONTROLLER requires CONTROLLEDt)interceding-token ngrams: responsible fortIe1: trigger-arg-path: requires >nsubj [lemma='interaction'] Generic_eventt2e1: ents2Label-mention-ngram: interaction requirestte2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of >nn controlled:Gene_or_gene_productt'interceding-token ngrams: are unknown .tme2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlledt#CSSPATH: ROOT >dep ++ ROOT >prep_totCe1: trigger-arg-path: requires:Positive_regulation >dobj controlledtae2: trigger-arg-path: Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlledtinterceding-token ngrams: PML ,t]e1: trigger-arg-path: requires:Positive_regulation >dobj [lemma='phosphorylation'] controlledthe1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='interaction'] controller:Generic_eventt(interceding-token ngrams: of degradationt'interceding-token ngrams: for mediatingt1interceding-token ngrams: kinases responsible fortEe1: trigger-arg-path: lemmatizedTrigger=require >dobj Phosphorylationt~e1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtUe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of >nn Gene_or_gene_producttme1: trigger-arg-path: requires:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtke1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='interaction'] controllertYe1: trigger-arg-path: requires >dobj [lemma='phosphorylation'] controlled:Phosphorylationt*interceding-token ngrams: , overexpressiont#interceding-token ngrams: mediatingt,interceding-token ngrams: degradation of PMLtte2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn [lemma='ubiquitin'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj controlled:Phosphorylationtve2: trigger-arg-path: Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: requires >dobj controlled:Phosphorylationt9e2: trigger-arg-path: degradation >prep_of >nn controlledt/interceding-token ngrams: architectural proteint'interceding-token ngrams: , are unknowntWe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='interaction'] controllertOe1: trigger-arg-path: lemmatizedTrigger=require >nsubj controller:Generic_eventtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='interaction'] Generic_eventtce2: trigger-arg-path: degradation >prep_of [lemma='protein'] >nn [lemma='pml'] Gene_or_gene_productt+interceding-token ngrams: for mediating thet+interceding-token ngrams: overexpression oftYe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj Phosphorylationt'interceding-token ngrams: , the kinasest8e2: trigger-arg-path: Negative_activation >nn controllertinterceding-token ngrams: , aretje2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn [lemma='ubiquitin'] controllertAe2: trigger-arg-path: Negative_activation >prep_of >nn controlledt+interceding-token ngrams: the interaction ,t-interceding-token ngrams: kinases responsiblet(interceding-token ngrams: overexpressiont]e1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='interaction'] Generic_eventtbe1: trigger-arg-path: requires:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtTe1: trigger-arg-path: requires >nsubj [lemma='interaction'] controller:Generic_eventt0e2: trigger-arg-path: degradation >nn controllert3interceding-token ngrams: responsible for mediatingt?e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='protein'] >nn [lemma='pml'] controlled:Gene_or_gene_productt4e1: trigger-arg-path: requires >dobj Phosphorylationt0e1: args2Role-mention-ngram: requires CONTROLLEDt(interceding-token ngrams: the downstreamt(interceding-token ngrams: degradation oftMe2: trigger-arg-path: degradation:Negative_activation >prep_of >nn controlledte2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn [lemma='ubiquitin'] controller:Gene_or_gene_productt interceding-token ngrams: of PMLtZe1: trigger-arg-path: lemmatizedTrigger=require >dobj [lemma='phosphorylation'] controlledtce1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj controller:Generic_eventtWe2: trigger-arg-path: degradation:Negative_activation >prep_of >nn Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of >nn controlled:Gene_or_gene_producttinterceding-token ngrams: PMLtYe2: trigger-arg-path: degradation:Negative_activation >nn controller:Gene_or_gene_productt:e2: trigger-arg-path: degradation >nn Gene_or_gene_producttRe1: trigger-arg-path: requires:Positive_regulation >nsubj controller:Generic_eventtDe2: trigger-arg-path: degradation:Negative_activation >nn controllertYe2: trigger-arg-path: degradation >prep_of [lemma='protein'] >nn [lemma='pml'] controlledt%interceding-token ngrams: HMGA2 leadst`e2: trigger-arg-path: lemmatizedTrigger=degradation >nn [lemma='ubiquitin'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=require >dobj [lemma='phosphorylation'] controlled:Phosphorylationtke2: trigger-arg-path: lemmatizedTrigger=degradation >nn [lemma='ubiquitin'] controller:Gene_or_gene_producttNe1: trigger-arg-path: requires >dobj [lemma='phosphorylation'] Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlled:Gene_or_gene_productt'interceding-token ngrams: protein HMGA2tae2: trigger-arg-path: Negative_activation >nn [lemma='ubiquitin'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj [lemma='phosphorylation'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=require >dobj [lemma='phosphorylation'] Phosphorylationt.interceding-token ngrams: downstream mechanismt-interceding-token ngrams: unknown . SimilarlytZe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='interaction'] Generic_eventtDe2: trigger-arg-path: degradation >nn [lemma='ubiquitin'] controllertFe1: trigger-arg-path: requires >nsubj [lemma='interaction'] controllert3e2: ents2Label-mention-ngram: dependent degradationt>e1: trigger-arg-path: Positive_regulation >nsubj Generic_eventt#interceding-token ngrams: PML , aretke2: trigger-arg-path: Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] Gene_or_gene_producttLe2: trigger-arg-path: Negative_activation >nn [lemma='ubiquitin'] controllertNe2: trigger-arg-path: degradation >prep_of >nn controlled:Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=require >dobj controlledtbe2: trigger-arg-path: degradation:Negative_activation >prep_of >nn controlled:Gene_or_gene_productt-interceding-token ngrams: , overexpression oft-interceding-token ngrams: protein HMGA2 leadst=e1: ents2Label-mention-ngram: requires SHARED phosphorylationt`e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn Gene_or_gene_productt!interceding-token ngrams: unknowntye1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='interaction'] controller:Generic_eventt+interceding-token ngrams: the architecturaltQe1: trigger-arg-path: Positive_regulation >nsubj [lemma='interaction'] controllertinterceding-token ngrams: HMGA2tue2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='protein'] >nn [lemma='pml'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of >nn controlledt'interceding-token ngrams: mediating thet"interceding-token ngrams: of PML ,t-e1: ents2Label-mention-ngram: requires SHAREDtee1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='interaction'] controller:Generic_eventtme2: trigger-arg-path: degradation:Negative_activation >nn [lemma='ubiquitin'] controller:Gene_or_gene_producttIe1: trigger-arg-path: requires >dobj [lemma='phosphorylation'] controlledt6e2: ents2Label-mention-ngram: dependent degradation oft&interceding-token ngrams: mechanism oftbe2: trigger-arg-path: degradation:Negative_activation >nn [lemma='ubiquitin'] Gene_or_gene_productt2interceding-token ngrams: mechanism of degradationt!interceding-token ngrams: kinasest+interceding-token ngrams: as the downstreamtVe2: trigger-arg-path: Negative_activation >prep_of >nn controlled:Gene_or_gene_productt>e1: trigger-arg-path: requires >nsubj controller:Generic_eventtZe1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='interaction'] controllertGe1: trigger-arg-path: requires:Positive_regulation >nsubj Generic_eventt+interceding-token ngrams: of degradation oft/interceding-token ngrams: overexpression of thetPe1: trigger-arg-path: lemmatizedTrigger=require >dobj controlled:PhosphorylationtSe1: trigger-arg-path: requires:Positive_regulation >dobj controlled:PhosphorylationtVe2: trigger-arg-path: Negative_activation >nn [lemma='ubiquitin'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of >nn controlledtEe2: trigger-arg-path: degradation >nn controller:Gene_or_gene_productte2: trigger: degradationtNe2: trigger-arg-path: degradation:Negative_activation >nn Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of >nn Gene_or_gene_producttHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dependent degradationtWe2: trigger-arg-path: lemmatizedTrigger=degradation >nn controller:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlledtDe1: trigger-arg-path: lemmatizedTrigger=require >nsubj Generic_eventt5interceding-token ngrams: architectural protein HMGA2twe2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] Gene_or_gene_producttNe2: trigger-arg-path: degradation >nn [lemma='ubiquitin'] Gene_or_gene_productt2interceding-token ngrams: the downstream mechanismt'interceding-token ngrams: architecturaltXe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj Generic_eventt.interceding-token ngrams: of the architecturalt%interceding-token ngrams: are unknownt1interceding-token ngrams: downstream mechanism oft interceding-token ngrams: as thet(e2: args2Role-mention-ngram: degradationt%interceding-token ngrams: responsiblet4interceding-token ngrams: Similarly , overexpressiont?interceding-tokens-full-span: , the kinases responsible for mediating the interaction , as well as the downstream mechanism of degradation of PML , are unknown . Similarly , overexpression of the architectural protein HMGA2 leads totne1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='interaction'] Generic_eventt/e1: trigger-arg-path: requires >dobj controlledt+e2: args2Role-mention-ngram: degradation oft=e2: args2Role-mention-ngram: CONTROLLER dependent degradationt%interceding-token ngrams: the kinasestYe2: trigger-arg-path: degradation >nn [lemma='ubiquitin'] controller:Gene_or_gene_productt%interceding-token ngrams: well as thet3interceding-token ngrams: the architectural proteintLe2: trigger-arg-path: lemmatizedTrigger=degradation >nn Gene_or_gene_productt?e2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='protein'] >nn [lemma='pml'] controlled:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >dobj controlledtke2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >nn controller:Gene_or_gene_producttMe2: trigger-arg-path: Negative_activation >nn controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: was not inhibitedtZe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: not inhibited byt_e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] controlledt]e1: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtYe2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledtHe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass Generic_eventtFe2: trigger-arg-path: inhibited >agent controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent controller:Gene_or_gene_producttYe1: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledtme1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtSe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass controlled:Generic_eventtge1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass controlled:Generic_eventt)e1: args2Role-mention-ngram: inhibited bytie1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: not inhibitedt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent controllert1e2: ents2Label-mention-ngram: phosphorylation wast+e1: args2Role-mention-ngram: CONTROLLED wastde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] controllert/e2: args2Role-mention-ngram: CONTROLLED was nott5e2: trigger-arg-path: inhibited >nsubjpass controlledtRe2: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] Generic_eventtJe1: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] controllertfe2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventt;e1: trigger-arg-path: Negative_regulation >agent controllert8e1: trigger-arg-path: inhibited >nsubjpass Generic_eventtIe2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass controlledtee2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] controller:Gene_or_gene_producttTe2: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] Generic_eventt1e1: trigger-arg-path: inhibited >agent controllertEe2: trigger-arg-path: inhibited:Negative_regulation >agent controllertse2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledtve2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventtOe1: trigger-arg-path: inhibited:Negative_regulation >agent Gene_or_gene_producttLe2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass Generic_eventt\e2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventtOe2: trigger-arg-path: inhibited:Negative_regulation >agent Gene_or_gene_producttJe2: trigger-arg-path: inhibited >agent [lemma='DACE'] Gene_or_gene_producttEe2: trigger-arg-path: Negative_regulation >agent Gene_or_gene_productt_e2: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_producttZe2: trigger-arg-path: inhibited:Negative_regulation >agent controller:Gene_or_gene_productt\e1: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventt]e2: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt-e1: args2Role-mention-ngram: not inhibited bytVe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: inhibited by CONTROLLERtHe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass Generic_eventtLe1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass Generic_eventtbe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] Generic_eventtKe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent Gene_or_gene_producttZe1: trigger-arg-path: inhibited:Negative_regulation >agent controller:Gene_or_gene_producttTe1: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: phosphorylation was nottVe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent controller:Gene_or_gene_producttCe2: trigger-arg-path: inhibited >nsubjpass controlled:Generic_eventtOe1: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] controlledtie2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: was not inhibitedt*e2: ents2Label-mention-ngram: inhibited bytKe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent Gene_or_gene_producttOe2: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] controlledtUe1: trigger-arg-path: inhibited >agent [lemma='DACE'] controller:Gene_or_gene_producttWe1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass controlled:Generic_eventtTe2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] controllert1e2: trigger-arg-path: inhibited >agent controllertAe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent controllert1e1: ents2Label-mention-ngram: inhibited by SHAREDtJe1: trigger-arg-path: inhibited >agent [lemma='DACE'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventt*e1: args2Role-mention-ngram: not inhibitedt?e1: trigger-arg-path: Negative_regulation >nsubjpass controlledtEe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass controlledt@e2: trigger-arg-path: inhibited >agent [lemma='DACE'] controllertSe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass controlled:Generic_eventt/e2: ents2Label-mention-ngram: was not inhibitedtYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass controlledtUe2: trigger-arg-path: inhibited >agent [lemma='DACE'] controller:Gene_or_gene_producttRe1: trigger-arg-path: inhibited >nsubjpass [lemma='phosphorylation'] Generic_eventtfe1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventtYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass controlledtce1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledt*e2: args2Role-mention-ngram: not inhibitedt.e1: args2Role-mention-ngram: was not inhibitedtse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledtEe1: trigger-arg-path: inhibited:Negative_regulation >agent controllertAe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent controllert\e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass Generic_eventtye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_producttTe1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] controllertee1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] controller:Gene_or_gene_producttqe1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt^e2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] Gene_or_gene_producttqe2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt\e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass Generic_eventtEe1: trigger-arg-path: Negative_regulation >agent Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] controlledtIe1: trigger-arg-path: inhibited:Negative_regulation >nsubjpass controlledtce2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlledt1e2: ents2Label-mention-ngram: inhibited by SHAREDtZe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] Gene_or_gene_productt4e2: args2Role-mention-ngram: inhibited by CONTROLLERt;e2: trigger-arg-path: inhibited >agent Gene_or_gene_producttFe1: trigger-arg-path: inhibited >agent controller:Gene_or_gene_productt8e2: trigger-arg-path: inhibited >nsubjpass Generic_eventtPe2: trigger-arg-path: Negative_regulation >agent controller:Gene_or_gene_productt5e1: trigger-arg-path: inhibited >nsubjpass controlledt.e2: ents2Label-mention-ngram: not inhibited byt_e1: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] controller:Gene_or_gene_producttMe1: trigger-arg-path: Negative_regulation >nsubjpass controlled:Generic_eventt+e2: args2Role-mention-ngram: CONTROLLED wast+e2: ents2Label-mention-ngram: not inhibitedtPe1: trigger-arg-path: Negative_regulation >agent controller:Gene_or_gene_producttBe1: trigger-arg-path: Negative_regulation >nsubjpass Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt@e1: trigger-arg-path: inhibited >agent [lemma='DACE'] controllertge2: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt/e1: args2Role-mention-ngram: CONTROLLED was nott)e2: args2Role-mention-ngram: inhibited byt_e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent Gene_or_gene_productt1e1: ents2Label-mention-ngram: phosphorylation wastJe2: trigger-arg-path: Negative_regulation >agent [lemma='DACE'] controllertPe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] controllertde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='DACE'] controllert;e1: trigger-arg-path: inhibited >agent Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtWe2: trigger-arg-path: inhibited:Negative_regulation >nsubjpass controlled:Generic_eventt^e1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='DACE'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubjpass controlledtAshortest-path: auxpass [lemma='be']tCe1: trigger-arg-path: inhibited >nsubjpass controlled:Generic_eventtPe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='DACE'] controllertge1: trigger-arg-path: Negative_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt5e1: ents2Label-mention-ngram: phosphorylation was nottge2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubjpass controlled:Generic_eventt-e2: args2Role-mention-ngram: not inhibited bytUe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent controllertie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] controllertXe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] controllertinterceding-token ngrams: al. ,tme2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_productt#interceding-token ngrams: Maurer ett-interceding-token ngrams: inhibition ( Maurertinterceding-token ngrams: , )tDe2: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] controllertbe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt%interceding-token ngrams: addition tot+e2: ents2Label-mention-ngram: SHARED at T92t.interceding-token ngrams: degradation of Mcl-1tinterceding-token ngrams: GSK3t%interceding-token ngrams: are blockedt%interceding-token ngrams: ( Maurer ett'interceding-token ngrams: has been showtYe2: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] controller:Gene_or_gene_productt)interceding-token ngrams: blocked by GSK3t8interceding-token ngrams: ubiquitination and degradationt%interceding-token ngrams: to GSK3betat"interceding-token ngrams: , it hast(interceding-token ngrams: been show thatt$interceding-token ngrams: of Mcl-1 ,t(interceding-token ngrams: are blocked byt#interceding-token ngrams: show thatt'interceding-token ngrams: to GSK3beta ,t,interceding-token ngrams: and degradation oft'interceding-token ngrams: Maurer et al.t$interceding-token ngrams: blocked bytSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] Gene_or_gene_productt(interceding-token ngrams: In addition tot"interceding-token ngrams: ( Maurert,interceding-token ngrams: by GSK3 inhibitiont7interceding-token ngrams: subsequent ubiquitination andt"interceding-token ngrams: of Mcl-1t^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_productt!interceding-token ngrams: al. , )t+interceding-token ngrams: which are blockedt%interceding-token ngrams: , which aret$interceding-token ngrams: GSK3beta ,t&interceding-token ngrams: inhibition (t"interceding-token ngrams: GSK3betat'interceding-token ngrams: GSK3beta , itt?interceding-tokens-full-span: and subsequent ubiquitination and degradation of Mcl-1 , which are blocked by GSK3 inhibition ( Maurer et al. , ) . In addition to GSK3beta , it has been show thatt interceding-token ngrams: Maurert$e2: ents2Label-mention-ngram: at T92tinterceding-token ngrams: showt.interceding-token ngrams: addition to GSK3betat#interceding-token ngrams: which aret7interceding-token ngrams: and subsequent ubiquitinationt3interceding-token ngrams: subsequent ubiquitinationt,interceding-token ngrams: ubiquitination andtUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] controllertIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='erk'] controllert)interceding-token ngrams: GSK3 inhibitiontinterceding-token ngrams: , ) .t!e2: ents2Label-mention-ngram: T92t!interceding-token ngrams: by GSK3t!interceding-token ngrams: Mcl-1 ,t#interceding-token ngrams: been showt+interceding-token ngrams: GSK3 inhibition (tse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt"interceding-token ngrams: et al. ,tinterceding-token ngrams: Mcl-1t(interceding-token ngrams: and subsequentt'interceding-token ngrams: Mcl-1 , whicht!interceding-token ngrams: blockedt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttNe2: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] controller:Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces S159tMe1: trigger-arg-path: inhibit:Negative_activation >nsubj Gene_or_gene_producttde1: trigger-arg-path: inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] Gene_or_gene_producttpe1: trigger-arg-path: Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] Gene_or_gene_producttoe1: trigger-arg-path: inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlled:Gene_or_gene_productt,interceding-token ngrams: This conclusion ist+interceding-token ngrams: with the reportedt{e1: trigger-arg-path: Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlled:Gene_or_gene_productt+interceding-token ngrams: ability of MCP110t.interceding-token ngrams: the reported abilitytVe1: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_producttHe2: trigger-arg-path: interactions:Binding >nn [lemma='ra'] theme:Familyt2interceding-token ngrams: conclusion is consistenttae1: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='raf'] themetGe1: trigger-arg-path: inhibit >dobj >nn controlled:Gene_or_gene_producttBe2: trigger-arg-path: interactions:Binding >nn [lemma='ra'] FamilytSe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] themet#e1: args2Role-mention-ngram: MCP116tle1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlledt2e1: trigger-arg-path: inhibit >dobj >nn controlledt*interceding-token ngrams: reported abilitytne1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] Gene_or_gene_productt?e1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] controllert:e2: trigger-arg-path: interactions >nn [lemma='ra'] FamilytDe2: trigger-arg-path: Binding >nn [lemma='raf'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mcp110'] controllertQe2: trigger-arg-path: interactions:Binding >nn [lemma='raf'] Gene_or_gene_productt,interceding-token ngrams: pathway downstreamtBe2: trigger-arg-path: interactions:Binding >nn [lemma='raf'] themet9e2: trigger-arg-path: interactions >nn [lemma='ra'] themet+interceding-token ngrams: . This conclusiont5e2: trigger-arg-path: interactions:Binding >nn Familyt(e1: ents2Label-mention-ngram: and MCP116t$interceding-token ngrams: ability oft&interceding-token ngrams: the reportedt$interceding-token ngrams: conclusiont+e1: args2Role-mention-ngram: MCP116 inhibitthe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] theme:Gene_or_gene_producttFe1: trigger-arg-path: inhibit:Negative_activation >dobj >nn controlledtbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] Gene_or_gene_productt/interceding-token ngrams: pathway downstream oft@e2: trigger-arg-path: interactions >nn [lemma='ra'] theme:Familyt,interceding-token ngrams: is consistent witht'e1: args2Role-mention-ngram: and MCP116t;e2: trigger-arg-path: interactions:Binding >nn theme:Familyt/e1: args2Role-mention-ngram: MCP116 inhibit thet+interceding-token ngrams: MCP110 to inhibitt(interceding-token ngrams: Ras activationt!interceding-token ngrams: abilitytve1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] Gene_or_gene_productt'interceding-token ngrams: is consistentt>e1: ents2Label-mention-ngram: inhibit the GENE_OR_GENE_PRODUCTtXe1: trigger-arg-path: inhibit:Negative_activation >nsubj controller:Gene_or_gene_producttfe1: trigger-arg-path: Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlledtie1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt&interceding-token ngrams: activation .tPe1: trigger-arg-path: inhibit:Negative_activation >dobj >nn Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_producttWe2: trigger-arg-path: interactions:Binding >nn [lemma='raf'] theme:Gene_or_gene_productt)interceding-token ngrams: This conclusiont0e1: ents2Label-mention-ngram: MCP116 inhibit thetpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_productt)CSSPATH: ROOT >ccomp ++ ROOT >xcomp >dobjt:e2: trigger-arg-path: interactions >nn [lemma='raf'] themet+interceding-token ngrams: activation . Thist?interceding-tokens-full-span: pathway downstream of Ras activation . This conclusion is consistent with the reported ability of MCP110 to inhibitt3e2: trigger-arg-path: interactions >nn theme:Familyt`e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] theme:Gene_or_gene_producttZe1: trigger-arg-path: inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlledt,e1: ents2Label-mention-ngram: MCP116 inhibittdobj >nn Gene_or_gene_productt^e1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_productt/e1: args2Role-mention-ngram: and MCP116 inhibitt0e1: ents2Label-mention-ngram: and MCP116 inhibittIe2: trigger-arg-path: interactions >nn [lemma='raf'] Gene_or_gene_productt[e1: trigger-arg-path: inhibit:Negative_activation >dobj >nn controlled:Gene_or_gene_producttxe1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLER and MCP116t-interceding-token ngrams: reported ability oftJe2: trigger-arg-path: Binding >nn [lemma='raf'] theme:Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and MCP116t-e2: trigger-arg-path: interactions >nn Familyt+interceding-token ngrams: of Ras activationt*interceding-token ngrams: Ras activation .t'interceding-token ngrams: conclusion istZe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] Gene_or_gene_producttTe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mcp110'] controllertOe2: trigger-arg-path: interactions >nn [lemma='raf'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] themet+interceding-token ngrams: downstream of Rast?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlledtAe2: trigger-arg-path: interactions:Binding >nn [lemma='ra'] themet?e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='pathway'] >nn [lemma='ras-raf-map'] controlled:Gene_or_gene_productt'interceding-token ngrams: downstream oft$e1: ents2Label-mention-ngram: MCP116tRe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] themetbe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: SHARED binding interactiont:e1: trigger-arg-path: interaction:Binding >nn theme:FamilytYe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] theme:FamilytJe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] themet@e1: trigger-arg-path: interaction:Binding >nn [lemma='ra'] themet4e1: trigger-arg-path: interaction:Binding >nn Familyt?e1: trigger-arg-path: interaction >nn [lemma='ra'] theme:FamilytLe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn theme:Familyt\e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] Gene_or_gene_producttCe1: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] themetMe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='cdc25'] themetRe1: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ra'] Familyt2e1: trigger-arg-path: interaction >nn theme:Familytje1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: THEME binding interactiont1e1: ents2Label-mention-ngram: binding interactiontJe1: trigger-arg-path: interaction >nn [lemma='cdc25'] Gene_or_gene_productt;e1: trigger-arg-path: interaction >nn [lemma='cdc25'] themetQe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] theme:FamilytKe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ra'] FamilytPe1: trigger-arg-path: interaction >nn [lemma='cdc25'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: binding interactiontUe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] themet,e1: trigger-arg-path: interaction >nn Familyt8e1: trigger-arg-path: interaction >nn [lemma='ra'] themetAe1: trigger-arg-path: interaction:Binding >nn [lemma='ra'] FamilytGe1: trigger-arg-path: interaction:Binding >nn [lemma='ra'] theme:FamilytFe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn Familytde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='cdc25'] Gene_or_gene_productt>e1: trigger-arg-path: lemmatizedTrigger=interaction >nn Familyt9e1: trigger-arg-path: interaction >nn [lemma='ra'] FamilytXe1: trigger-arg-path: interaction:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=interaction >nn theme:Familyt$e2: args2Role-mention-ngram: ( FGF-2t/e1: args2Role-mention-ngram: CONTROLLER and p44t?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt!interceding-token ngrams: alaninet'e2: ents2Label-mention-ngram: 2 ( FGF-2t$e2: args2Role-mention-ngram: FGF-2 )t#interceding-token ngrams: vitro andt e2: args2Role-mention-ngram: 2 (tae2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] Phosphorylationt!e1: ents2Label-mention-ngram: p44t(e1: args2Role-mention-ngram: p44 mitogentue2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtJe2: trigger-arg-path: stimulates:Positive_regulation >dobj Phosphorylationt7e1: ents2Label-mention-ngram: mitogen activated proteint.interceding-token ngrams: to alanine decreasest#interceding-token ngrams: decreasest*e1: args2Role-mention-ngram: kinase ( MAPKtte1: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt#interceding-token ngrams: Thr739 inte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert)e2: args2Role-mention-ngram: ) stimulatest&e2: args2Role-mention-ngram: 2 ( FGF-2t_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllertAe2: trigger-arg-path: stimulates >dobj controlled:Phosphorylationt"interceding-token ngrams: sites totoe2: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtUe2: trigger-arg-path: stimulates:Positive_regulation >dobj controlled:Phosphorylationt$e1: ents2Label-mention-ngram: MAPK )t/e1: ents2Label-mention-ngram: mitogen activatedt&interceding-token ngrams: and mutationtRe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlled:Phosphorylationt&interceding-token ngrams: in vitro andt4interceding-token ngrams: transcriptional activity .tre2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='factor'] Gene_or_gene_productt)interceding-token ngrams: Thr739 in vitrot$interceding-token ngrams: to alaninet7e1: ents2Label-mention-ngram: ) directly phosphorylatest$e1: ents2Label-mention-ngram: Thr453t)interceding-token ngrams: and mutation oftke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert\e2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] controlledtEe2: trigger-arg-path: stimulates:Positive_regulation >dobj controlledt[e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj Phosphorylationt$interceding-token ngrams: vivo , andtne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert,e1: args2Role-mention-ngram: MAPK ) directlytKe2: trigger-arg-path: stimulates >dobj [lemma='phosphorylation'] controlledt-e1: ents2Label-mention-ngram: and p44 mitogent interceding-token ngrams: vivo ,t"e2: args2Role-mention-ngram: FGF-2tie2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='factor'] controller:Gene_or_gene_productt[e2: trigger-arg-path: stimulates:Positive_regulation >nsubj controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 2 (tXe2: trigger-arg-path: stimulates >nsubj [lemma='factor'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: and p44tMe2: trigger-arg-path: stimulates >nsubj [lemma='factor'] Gene_or_gene_producttGe2: trigger-arg-path: stimulates >nsubj controller:Gene_or_gene_producttoe1: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_producttZe1: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert#e1: args2Role-mention-ngram: MAPK )t^e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='factor'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: at Thr453tVe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj controlledt#e2: ents2Label-mention-ngram: FGF-2tTe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='factor'] controllert%e1: ents2Label-mention-ngram: and p44tfe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj controlled:Phosphorylationt.e1: ents2Label-mention-ngram: SHARED at Thr453t1e2: ents2Label-mention-ngram: ) stimulates SHAREDt?interceding-tokens-full-span: and Thr739 in vitro and in vivo , and mutation of these sites to alanine decreases Sp1 transcriptional activity . In addition ,t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt?e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt#interceding-token ngrams: in vivo ,t2e1: args2Role-mention-ngram: p44 mitogen activatedt6e1: args2Role-mention-ngram: mitogen activated proteintxe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt_e2: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='phosphorylation'] controlledt%interceding-token ngrams: mutation oft(interceding-token ngrams: , and mutationthe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='factor'] controllert+interceding-token ngrams: mutation of theset?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt"interceding-token ngrams: of theset6e2: trigger-arg-path: stimulates >dobj Phosphorylationt%interceding-token ngrams: these sitest+e2: args2Role-mention-ngram: CONTROLLER 2 (t e1: args2Role-mention-ngram: p44t+interceding-token ngrams: alanine decreasest/interceding-token ngrams: alanine decreases Sp1t$interceding-token ngrams: and Thr739tpe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] controlledt3e1: ents2Label-mention-ngram: p44 mitogen activatedt interceding-token ngrams: Thr739t!e2: ents2Label-mention-ngram: 2 (t$e1: ents2Label-mention-ngram: ( MAPKtae2: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='factor'] Gene_or_gene_producttCe2: trigger-arg-path: stimulates >nsubj [lemma='factor'] controllert6interceding-token ngrams: Sp1 transcriptional activityt?e2: ents2Label-mention-ngram: stimulates SHARED phosphorylationt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p44tnsubj Gene_or_gene_productt%e2: ents2Label-mention-ngram: FGF-2 )t[e2: trigger-arg-path: stimulates >dobj [lemma='phosphorylation'] controlled:Phosphorylationt(interceding-token ngrams: these sites tot4e2: args2Role-mention-ngram: ) stimulates CONTROLLEDt'interceding-token ngrams: and Thr739 int+e1: ents2Label-mention-ngram: kinase ( MAPKt4e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 2t-e1: ents2Label-mention-ngram: MAPK ) directlyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='factor'] controller:Gene_or_gene_productt2e1: args2Role-mention-ngram: ) directly CONTROLLEDtie1: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_producttFe2: trigger-arg-path: stimulates:Positive_regulation >nsubj controllert&e2: args2Role-mention-ngram: ( FGF-2 )t*e2: ents2Label-mention-ngram: ) stimulatest0e2: ents2Label-mention-ngram: FGF-2 ) stimulatest!e1: args2Role-mention-ngram: MAPKtPe2: trigger-arg-path: stimulates >dobj [lemma='phosphorylation'] Phosphorylationt'e2: ents2Label-mention-ngram: ( FGF-2 )t%e1: args2Role-mention-ngram: ( MAPK )tde2: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt%e2: ents2Label-mention-ngram: ( FGF-2t/e2: args2Role-mention-ngram: FGF-2 ) stimulatest'e1: args2Role-mention-ngram: ) directlyt.e1: args2Role-mention-ngram: mitogen activatedt'interceding-token ngrams: decreases Sp1t%interceding-token ngrams: and in vivot&e1: ents2Label-mention-ngram: ( MAPK )t-interceding-token ngrams: Sp1 transcriptionalt)e1: ents2Label-mention-ngram: p44 mitogentle2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] controlled:PhosphorylationtGe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj Phosphorylationt*interceding-token ngrams: sites to alaninet(e1: ents2Label-mention-ngram: ) directlytWe2: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='factor'] controllert&interceding-token ngrams: vitro and int2e2: trigger-arg-path: stimulates >nsubj controllertle2: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='factor'] controller:Gene_or_gene_producttPe2: trigger-arg-path: stimulates:Positive_regulation >nsubj Gene_or_gene_productt,e1: args2Role-mention-ngram: and p44 mitogent(interceding-token ngrams: of these sitestde1: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt#e1: args2Role-mention-ngram: ( MAPKt%e1: ents2Label-mention-ngram: mitogent$e1: args2Role-mention-ngram: mitogent7interceding-token ngrams: decreases Sp1 transcriptionalt8e1: trigger-arg-path: binds >dobj [lemma='fkbp38'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] themet=e2: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] themetOe2: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] Gene_or_gene_producttMe2: trigger-arg-path: binds >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttXe1: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttXe2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binds >dobj [lemma='fkbp38'] Gene_or_gene_producttCe2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] themetIe1: trigger-arg-path: Binding >dobj [lemma='fkbp38'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttGe2: trigger-arg-path: binds >dobj [lemma='fkbp38'] Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttJe2: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >dobj [lemma='fkbp38'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] themet8e2: trigger-arg-path: binds >dobj [lemma='fkbp38'] themetQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] themetPe2: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_productt@e2: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] themetJe1: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] themetIe2: trigger-arg-path: Binding >dobj [lemma='fkbp38'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] themet;e2: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] themetLe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb-gtp'] themetRe2: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] theme:Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] themet=e1: trigger-arg-path: Binding >nsubj [lemma='rheb-gtp'] themetOe1: trigger-arg-path: binds:Binding >dobj [lemma='fkbp38'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] themetce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='fkbp38'] Gene_or_gene_producttMe1: trigger-arg-path: binds >dobj [lemma='fkbp38'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb-gtp'] Gene_or_gene_productt:e2: trigger-arg-path: Binding >dobj [lemma='fkbp38'] themet;e1: trigger-arg-path: binds >nsubj [lemma='rheb-gtp'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='fkbp38'] Gene_or_gene_producttOe2: trigger-arg-path: interacts >nsubj [lemma='taf-1beta'] Gene_or_gene_productt;e2: ents2Label-mention-ngram: and with GENE_OR_GENE_PRODUCTtPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='klf5'] themetNe2: trigger-arg-path: interacts >prep_with [lemma='klf5'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: Sp-1tne2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='taf-1beta'] theme:Gene_or_gene_productt interceding-token ngrams: KLF5 ,t$interceding-token ngrams: negativelyt+e2: args2Role-mention-ngram: and with THEMEt6e2: args2Role-mention-ngram: Sp-1 transcription factort'interceding-token ngrams: and with KLF5tQe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='taf-1beta'] themet'e2: args2Role-mention-ngram: THEME alsot>e2: trigger-arg-path: Binding >nsubj [lemma='taf-1beta'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='klf5'] themet%interceding-token ngrams: , TAF-1betatHe2: trigger-arg-path: interacts:Binding >nsubj [lemma='taf-1beta'] themet.interceding-token ngrams: Moreover , TAF-1betat(interceding-token ngrams: regulating thet"interceding-token ngrams: the Sp-1t_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='klf5'] Gene_or_gene_productt*e2: args2Role-mention-ngram: with the Sp-1t\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='klf5'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interacts >prep_with [lemma='klf5'] theme:Gene_or_gene_productt2interceding-token ngrams: transcription factor andtGe2: trigger-arg-path: interacts:Binding >prep_with [lemma='klf5'] themet0e2: ents2Label-mention-ngram: Sp-1 transcriptiont+interceding-token ngrams: KLF5 , negativelytXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='klf5'] themet%e2: args2Role-mention-ngram: the Sp-1t/e2: args2Role-mention-ngram: Sp-1 transcriptiont?interceding-tokens-full-span: . Moreover , TAF-1beta also interacts with the Sp-1 transcription factor and with KLF5 , negatively regulating thet#interceding-token ngrams: TAF-1betat-interceding-token ngrams: also interacts withtRe2: trigger-arg-path: Binding >prep_with [lemma='klf5'] theme:Gene_or_gene_productt0interceding-token ngrams: the Sp-1 transcriptiont7e2: ents2Label-mention-ngram: Sp-1 transcription factortSe2: trigger-arg-path: Binding >nsubj [lemma='taf-1beta'] theme:Gene_or_gene_productt%interceding-token ngrams: with KLF5 ,t+e2: ents2Label-mention-ngram: with the Sp-1t]e2: trigger-arg-path: interacts:Binding >nsubj [lemma='taf-1beta'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: the Sp-1 transcriptiont(interceding-token ngrams: TAF-1beta alsotUe2: trigger-arg-path: interacts >nsubj [lemma='taf-1beta'] theme:Gene_or_gene_productt*interceding-token ngrams: , TAF-1beta alsot7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT alsot&e2: ents2Label-mention-ngram: the Sp-1t/interceding-token ngrams: negatively regulatingt#interceding-token ngrams: with KLF5tLe2: trigger-arg-path: Binding >prep_with [lemma='klf5'] Gene_or_gene_productt!e2: args2Role-mention-ngram: Sp-1t"interceding-token ngrams: and witht3interceding-token ngrams: negatively regulating thetinterceding-token ngrams: KLF5tMe2: trigger-arg-path: Binding >nsubj [lemma='taf-1beta'] Gene_or_gene_productt'interceding-token ngrams: with the Sp-1t$interceding-token ngrams: factor andt9e1: ents2Label-mention-ngram: with GENE_OR_GENE_PRODUCT (tme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='klf5'] theme:Gene_or_gene_productt,interceding-token ngrams: Sp-1 transcriptiont&interceding-token ngrams: , negativelyt`e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='taf-1beta'] Gene_or_gene_producttWe2: trigger-arg-path: interacts:Binding >nsubj [lemma='taf-1beta'] Gene_or_gene_productt%e2: args2Role-mention-ngram: and withtVe2: trigger-arg-path: interacts:Binding >prep_with [lemma='klf5'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='taf-1beta'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: factor and witht$interceding-token ngrams: regulatingtAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also interactst)interceding-token ngrams: factor and witht,e2: args2Role-mention-ngram: factor and witht@e2: trigger-arg-path: interacts >nsubj [lemma='taf-1beta'] themetnsubj [lemma='taf-1beta'] themet1e2: args2Role-mention-ngram: THEME also interactst(interceding-token ngrams: also interactst3e2: args2Role-mention-ngram: the Sp-1 transcriptionthe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='taf-1beta'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and withtee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='klf5'] theme:Gene_or_gene_productt?e2: trigger-arg-path: interacts >prep_with [lemma='klf5'] themet3interceding-token ngrams: Sp-1 transcription factortge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='klf5'] Gene_or_gene_producttLe1: trigger-arg-path: interactions >poss [lemma='they'] theme:Generic_entitytVe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss theme:Generic_entitytEe1: trigger-arg-path: interactions:Binding >poss theme:Generic_entityt?e2: trigger-arg-path: interactions:Binding >poss Generic_entityt=e1: trigger-arg-path: interactions >poss theme:Generic_entitytNe1: trigger-arg-path: lemmatizedTrigger=interaction >poss theme:Generic_entityt/e1: args2Role-mention-ngram: THEME interactionst=e2: trigger-arg-path: interactions >poss theme:Generic_entitytTe1: trigger-arg-path: interactions:Binding >poss [lemma='they'] theme:Generic_entitytshortest-path: poss [lemma='they'] Generic_entityt6e1: trigger-arg-path: interactions:Binding >poss themetFe1: trigger-arg-path: interactions >poss [lemma='they'] Generic_entityt]e1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] theme:Generic_entitytEe1: trigger-arg-path: interactions:Binding >poss [lemma='they'] themet_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] Generic_entitytVe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] themetNe1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] themet.e1: trigger-arg-path: interactions >poss themetGe1: trigger-arg-path: Binding >poss [lemma='they'] theme:Generic_entityt=e1: trigger-arg-path: interactions >poss [lemma='they'] themet9e1: ents2Label-mention-ngram: GENERIC_ENTITY interactionst=e2: trigger-arg-path: interactions >poss [lemma='they'] themetNe1: trigger-arg-path: interactions:Binding >poss [lemma='they'] Generic_entitytGe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss themet6e2: trigger-arg-path: interactions:Binding >poss themetNe2: trigger-arg-path: interactions:Binding >poss [lemma='they'] Generic_entitytee1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='they'] theme:Generic_entitytHe1: trigger-arg-path: lemmatizedTrigger=interaction >poss Generic_entitytEe2: trigger-arg-path: interactions:Binding >poss theme:Generic_entityt*shortest-path: poss [lemma='they'] Generic_entityt7e2: trigger-arg-path: interactions >poss Generic_entityt8e1: trigger-arg-path: Binding >poss [lemma='they'] themet?e1: trigger-arg-path: interactions:Binding >poss Generic_entitytWe1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='they'] Generic_entitytPe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss Generic_entitytTe2: trigger-arg-path: interactions:Binding >poss [lemma='they'] theme:Generic_entitytEe2: trigger-arg-path: interactions:Binding >poss [lemma='they'] themetLe2: trigger-arg-path: interactions >poss [lemma='they'] theme:Generic_entityt.e2: trigger-arg-path: interactions >poss themet?e1: trigger-arg-path: lemmatizedTrigger=interaction >poss themet7e1: trigger-arg-path: interactions >poss Generic_entityt7e1: args2Role-mention-ngram: THEME physical interactiontXe2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of Gene_or_gene_productt+interceding-token ngrams: not the mechanismtve2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] theme:Gene_or_gene_productt[e2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: heterodimerization andt'interceding-token ngrams: the mechanismtYe2: trigger-arg-path: heterodimerization:Binding >prep_of >prep_with Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] themetfe2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of theme:Gene_or_gene_productt-e1: trigger-arg-path: interaction >poss themete2: trigger: heterodimerizationtae2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] themet)e2: args2Role-mention-ngram: crosstalk oft>e1: trigger-arg-path: interaction:Binding >poss Generic_entitytposs theme:Generic_entityt`e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] themetee2: trigger-arg-path: Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] Gene_or_gene_producttVe2: trigger-arg-path: Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] themetqe2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of >prep_with theme:Gene_or_gene_producttFe2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] themet;e2: trigger-arg-path: Binding >prep_of [lemma='egfr'] themet*e2: args2Role-mention-ngram: and crosstalktQe2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of themet0e2: ents2Label-mention-ngram: heterodimerizationtFe2: trigger-arg-path: heterodimerization >prep_of Gene_or_gene_productt interceding-token ngrams: case .tpe2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] Gene_or_gene_producttce2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] theme:Gene_or_gene_productt!interceding-token ngrams: in thist?e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] theme:Gene_or_gene_productt#interceding-token ngrams: crosstalkt0interceding-token ngrams: mechanism of crosstalkt#interceding-token ngrams: this caset/e2: args2Role-mention-ngram: heterodimerizationt_e2: trigger-arg-path: heterodimerization:Binding >prep_of >prep_with theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of >prep_with themetPe2: trigger-arg-path: Binding >prep_of [lemma='egfr'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of >prep_with theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: crosstalk of THEMEt1e2: ents2Label-mention-ngram: crosstalk of SHAREDt+e2: ents2Label-mention-ngram: and crosstalkt`e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of Gene_or_gene_productt&interceding-token ngrams: crosstalk int?e2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_of [lemma='egfr'] Gene_or_gene_producttDe1: trigger-arg-path: interaction:Binding >poss theme:Generic_entityt\e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of >prep_with themetMe1: trigger-arg-path: interaction:Binding >poss [lemma='they'] Generic_entitytJe2: trigger-arg-path: heterodimerization:Binding >prep_of >prep_with themet=e2: args2Role-mention-ngram: heterodimerization and crosstalktNe2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] themetue2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] theme:Gene_or_gene_productt$interceding-token ngrams: is not thetposs [lemma='they'] themet.e2: ents2Label-mention-ngram: and crosstalk oftke2: trigger-arg-path: Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] theme:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] Gene_or_gene_productt?e2: trigger-arg-path: heterodimerization:Binding >prep_of themet?e2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of >prep_with Gene_or_gene_producttUe2: trigger-arg-path: heterodimerization >prep_of [lemma='egfr'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] themet5e1: ents2Label-mention-ngram: GENERIC_ENTITY physicalt?e2: trigger-arg-path: lemmatizedTrigger=heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] Gene_or_gene_productt3e2: args2Role-mention-ngram: heterodimerization andt%interceding-token ngrams: this case .tAe1: ents2Label-mention-ngram: GENERIC_ENTITY physical interactiont6e1: trigger-arg-path: interaction >poss Generic_entityt5e1: trigger-arg-path: interaction:Binding >poss themetce2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of >prep_with Gene_or_gene_productt&interceding-token ngrams: of crosstalkt$interceding-token ngrams: case . Thet>e2: ents2Label-mention-ngram: heterodimerization and crosstalktBe2: trigger-arg-path: heterodimerization >prep_of >prep_with themet+interceding-token ngrams: crosstalk in thistSe1: trigger-arg-path: interaction:Binding >poss [lemma='they'] theme:Generic_entityt&interceding-token ngrams: in this caset*interceding-token ngrams: the mechanism oftxe2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] Gene_or_gene_producttRinterceding-tokens-full-span: is not the mechanism of crosstalk in this case . ThetDe1: trigger-arg-path: interaction:Binding >poss [lemma='they'] themetNe2: trigger-arg-path: heterodimerization:Binding >prep_of Gene_or_gene_producttQe2: trigger-arg-path: heterodimerization >prep_of >prep_with Gene_or_gene_producttEe1: trigger-arg-path: interaction >poss [lemma='they'] Generic_entitytLe2: trigger-arg-path: heterodimerization >prep_of theme:Gene_or_gene_producttKe1: trigger-arg-path: interaction >poss [lemma='they'] theme:Generic_entitytWe2: trigger-arg-path: heterodimerization >prep_of >prep_with theme:Gene_or_gene_producttinterceding-token ngrams: casetme2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] theme:Gene_or_gene_productt7e2: trigger-arg-path: heterodimerization >prep_of themet-e2: args2Role-mention-ngram: and crosstalk oft&e2: args2Role-mention-ngram: crosstalkt+e1: args2Role-mention-ngram: THEME physicaltTe2: trigger-arg-path: heterodimerization:Binding >prep_of theme:Gene_or_gene_productt,CSSPATH: ROOT >dep >nsubj ++ ROOT >nsubjpasst*e2: ents2Label-mention-ngram: crosstalk oft'e2: ents2Label-mention-ngram: crosstalkt]e2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of themetXe2: trigger-arg-path: lemmatizedTrigger=heterodimerization >prep_of [lemma='egfr'] themet~e2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] theme:Gene_or_gene_producttie2: trigger-arg-path: heterodimerization:Binding >prep_of [lemma='egfr'] >prep_with [lemma='c-met'] themet)interceding-token ngrams: of crosstalk int^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='icb'] theme:Gene_or_gene_producttce2: trigger-arg-path: interact:Binding nsubjpass [lemma='it'] Generic_entityt'interceding-token ngrams: the inductiontQe2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass Generic_entityt!e2: args2Role-mention-ngram: NF-YtGe1: trigger-arg-path: binds >prep_to [lemma='icb'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cbp'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: to the bimtKe2: trigger-arg-path: Binding >prep_with [lemma='cbp'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: ) binds tot+e2: ents2Label-mention-ngram: that NF-Y andtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nf-y'] themet'e2: ents2Label-mention-ngram: that NF-Yt4e1: ents2Label-mention-ngram: transcription factor YtIe1: trigger-arg-path: Binding >prep_to [lemma='icb'] Gene_or_gene_productt,e1: args2Role-mention-ngram: THEME ( nucleart/e2: ents2Label-mention-ngram: interact with thet`e2: trigger-arg-path: Binding nsubjpass [lemma='it'] theme:Generic_entitytOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cbp'] themet>e2: trigger-arg-path: Binding nsubjpass Generic_entityt(e1: args2Role-mention-ngram: the bim ICBtfe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cbp'] Gene_or_gene_productt#interceding-token ngrams: essentialtWe2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass theme:Generic_entityt'e1: args2Role-mention-ngram: ) binds totMe1: trigger-arg-path: binds >prep_to [lemma='icb'] theme:Gene_or_gene_producttprep_with [lemma='cbp'] themet&e1: ents2Label-mention-ngram: both thet@e1: trigger-arg-path: binds:Binding >prep_to [lemma='icb'] themet%e1: args2Role-mention-ngram: factor Ytde2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='it'] themetue2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='it'] Generic_entityt&e2: args2Role-mention-ngram: that NF-Yt9e1: args2Role-mention-ngram: nuclear transcription factort3e1: ents2Label-mention-ngram: nuclear transcriptiont?interceding-tokens-full-span: and NF-Y activity are essential for the induction of the bim-LUC reporter after NGF withdrawal . Furthermore ,t/e2: args2Role-mention-ngram: coactivators THEMEt3e2: ents2Label-mention-ngram: with the coactivatorst*interceding-token ngrams: induction of thetinterceding-token ngrams: NF-Yt"e2: ents2Label-mention-ngram: NF-Ytle2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cbp'] theme:Gene_or_gene_productt!e1: ents2Label-mention-ngram: ICBt&e1: ents2Label-mention-ngram: factor Yt4e1: args2Role-mention-ngram: ( nuclear transcriptiont"interceding-token ngrams: reportert'interceding-token ngrams: are essentialt$e1: args2Role-mention-ngram: the bimt-e2: ents2Label-mention-ngram: shown that NF-Yt"interceding-token ngrams: and NF-Yt+e1: args2Role-mention-ngram: both the THEMEt*interceding-token ngrams: the induction oftle2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='it'] themete1: ents2Label-mention-ngram: YtMe2: trigger-arg-path: interact:Binding nsubjpass theme:Generic_entityt2e1: args2Role-mention-ngram: nuclear transcriptiont$interceding-token ngrams: withdrawaltde2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cbp'] theme:Gene_or_gene_productt(interceding-token ngrams: of the bim-LUCt?e2: trigger-arg-path: interact nsubjpass Generic_entitytIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='icb'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='icb'] themet#interceding-token ngrams: after NGFt{e2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass [lemma='it'] theme:Generic_entitytinterceding-token ngrams: NGFt)e1: ents2Label-mention-ngram: bim ICB andtHe1: trigger-arg-path: Binding >nsubj [lemma='nf-y'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: the coactivatorst,e2: args2Role-mention-ngram: shown that NF-Yt-e2: ents2Label-mention-ngram: FOXO3a interactt8e1: trigger-arg-path: binds >prep_to [lemma='icb'] themet+interceding-token ngrams: and NF-Y activityt%e1: args2Role-mention-ngram: and botht-e2: ents2Label-mention-ngram: NF-Y and FOXO3at'e2: args2Role-mention-ngram: shown thatt.interceding-token ngrams: the bim-LUC reportert*e2: ents2Label-mention-ngram: coactivatorst%e1: ents2Label-mention-ngram: the bimt e1: args2Role-mention-ngram: Y )t&interceding-token ngrams: activity aret!e1: ents2Label-mention-ngram: bimtUe1: trigger-arg-path: binds:Binding >prep_to [lemma='icb'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: THEME was shownt,e2: args2Role-mention-ngram: FOXO3a interacttEe2: trigger-arg-path: interact:Binding >prep_with [lemma='cbp'] themet&e1: ents2Label-mention-ngram: and bothtGe2: trigger-arg-path: interact:Binding nsubjpass Generic_entitytWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cbp'] themet0e2: args2Role-mention-ngram: and FOXO3a interactt%e2: args2Role-mention-ngram: NF-Y andt,interceding-token ngrams: reporter after NGFt;e1: ents2Label-mention-ngram: both the GENE_OR_GENE_PRODUCTt(e1: ents2Label-mention-ngram: factor Y )tDe2: trigger-arg-path: Binding nsubjpass theme:Generic_entitytOe1: trigger-arg-path: Binding >prep_to [lemma='icb'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nf-y'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: was showntNe1: trigger-arg-path: binds:Binding >nsubj [lemma='nf-y'] Gene_or_gene_productt7e1: trigger-arg-path: binds >nsubj [lemma='nf-y'] themet&interceding-token ngrams: withdrawal .t:e1: ents2Label-mention-ngram: nuclear transcription factortLe1: trigger-arg-path: binds >nsubj [lemma='nf-y'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: ( nucleart&e1: args2Role-mention-ngram: Y ) bindst*CSSPATH: ROOT >csubj >ccomp ++ ROOT >ccompt(e2: ents2Label-mention-ngram: shown thatt)e1: args2Role-mention-ngram: and both thetTe1: trigger-arg-path: binds:Binding >nsubj [lemma='nf-y'] theme:Gene_or_gene_productt+interceding-token ngrams: for the inductiont(e2: ents2Label-mention-ngram: and FOXO3atie2: trigger-arg-path: interact:Binding nsubjpass [lemma='it'] theme:Generic_entityt,e2: args2Role-mention-ngram: NF-Y and FOXO3atHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nf-y'] themet2interceding-token ngrams: withdrawal . Furthermoret'e2: args2Role-mention-ngram: and FOXO3at!interceding-token ngrams: bim-LUCtRe2: trigger-arg-path: interact nsubjpass [lemma='it'] themet1e2: args2Role-mention-ngram: FOXO3a interact witht_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nf-y'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='it'] Generic_entitytZe2: trigger-arg-path: interact:Binding nsubjpass [lemma='it'] themet'e1: args2Role-mention-ngram: factor Y )t e1: args2Role-mention-ngram: ICBtZe2: trigger-arg-path: Binding nsubjpass [lemma='it'] Generic_entitytYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass Generic_entityt%e1: ents2Label-mention-ngram: ICB andt$e1: args2Role-mention-ngram: ICB andt(e1: args2Role-mention-ngram: bim ICB andte1: args2Role-mention-ngram: Yt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nf-y'] theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: GENERIC_ENTITY was shownt+e2: args2Role-mention-ngram: was shown thattQe2: trigger-arg-path: Binding nsubjpass [lemma='it'] themet+interceding-token ngrams: NF-Y activity aret&e2: args2Role-mention-ngram: was shownt&e2: ents2Label-mention-ngram: NF-Y andtOe1: trigger-arg-path: binds:Binding >prep_to [lemma='icb'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: ( nucleart?e1: trigger-arg-path: binds:Binding >nsubj [lemma='nf-y'] themet_e2: trigger-arg-path: lemmatizedTrigger=interact:Binding nsubjpass theme:Generic_entityt9e1: trigger-arg-path: Binding >nsubj [lemma='nf-y'] themetse2: trigger-arg-path: lemmatizedTrigger=interact nsubjpass [lemma='it'] theme:Generic_entityt$e2: ents2Label-mention-ngram: FOXO3at,e2: ents2Label-mention-ngram: was shown thatt5e1: ents2Label-mention-ngram: ( nuclear transcriptiontFe1: trigger-arg-path: binds >nsubj [lemma='nf-y'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='icb'] Gene_or_gene_producttae2: trigger-arg-path: interact nsubjpass [lemma='it'] theme:Generic_entityt-e2: args2Role-mention-ngram: the coactivatorstprep_with [lemma='cbp'] themet*interceding-token ngrams: bim-LUC reportertRe2: trigger-arg-path: interact >prep_with [lemma='cbp'] theme:Gene_or_gene_productt.interceding-token ngrams: after NGF withdrawaltZe2: trigger-arg-path: interact:Binding >prep_with [lemma='cbp'] theme:Gene_or_gene_productt+interceding-token ngrams: are essential fort0e2: ents2Label-mention-ngram: GENERIC_ENTITY wast3e2: args2Role-mention-ngram: the coactivators THEMEt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='icb'] Gene_or_gene_productt0interceding-token ngrams: bim-LUC reporter aftert%e1: ents2Label-mention-ngram: bim ICBt%interceding-token ngrams: the bim-LUCt$e1: args2Role-mention-ngram: bim ICBt*e1: ents2Label-mention-ngram: and both thetLe2: trigger-arg-path: interact >prep_with [lemma='cbp'] Gene_or_gene_productt e1: args2Role-mention-ngram: bimtQe2: trigger-arg-path: Binding >prep_with [lemma='cbp'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: that NF-Y andt)e1: ents2Label-mention-ngram: the bim ICBt.e2: args2Role-mention-ngram: interact with thet)e1: args2Role-mention-ngram: ICB and botht*interceding-token ngrams: NGF withdrawal .t0interceding-token ngrams: activity are essentialt(interceding-token ngrams: reporter aftert?e2: ents2Label-mention-ngram: coactivators GENE_OR_GENE_PRODUCTtNe1: trigger-arg-path: Binding >nsubj [lemma='nf-y'] theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: with the coactivatorstfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='icb'] theme:Gene_or_gene_productt!e1: ents2Label-mention-ngram: Y )t)e2: args2Role-mention-ngram: coactivatorst'e1: ents2Label-mention-ngram: Y ) bindst:e1: trigger-arg-path: Binding >prep_to [lemma='icb'] themet+interceding-token ngrams: essential for thetCe2: ents2Label-mention-ngram: the coactivators GENE_OR_GENE_PRODUCTt2e2: ents2Label-mention-ngram: FOXO3a interact witht[e2: trigger-arg-path: interact nsubjpass [lemma='it'] Generic_entityt'e1: args2Role-mention-ngram: to the bimtTe2: trigger-arg-path: interact:Binding >prep_with [lemma='cbp'] Gene_or_gene_productt'interceding-token ngrams: NF-Y activityt#e2: args2Role-mention-ngram: FOXO3at'interceding-token ngrams: essential fortWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nf-y'] Gene_or_gene_producttEe2: trigger-arg-path: interact nsubjpass theme:Generic_entityt3e1: args2Role-mention-ngram: transcription factor Yt1e1: ents2Label-mention-ngram: MTH1 suppression int.interceding-token ngrams: been comprehensivelyt?e2: trigger-arg-path: associated >prep_with >nn Simple_chemicaltPe2: trigger-arg-path: associated prep_with >nn themet6e2: ents2Label-mention-ngram: mammary epithelial cellstde2: trigger-arg-path: associated:Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] themetVe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with >nn theme:Simple_chemicalt'interceding-token ngrams: MMP 3 inducedt)interceding-token ngrams: comprehensivelyt&e1: ents2Label-mention-ngram: stemmingt%e2: args2Role-mention-ngram: cellulartinterceding-token ngrams: RASt%e2: ents2Label-mention-ngram: mammaryt5e2: trigger-arg-path: associated >prep_with >nn themet@e1: trigger-arg-path: reduces >nsubj [lemma='damage'] controllertSe2: trigger-arg-path: lemmatizedTrigger=associate dobj >nn controlled:Gene_or_gene_productt}e1: trigger-arg-path: reduces:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: mammary epithelialt&e2: ents2Label-mention-ngram: in mouset+e2: args2Role-mention-ngram: THEME in mouset$e1: args2Role-mention-ngram: reducest*e1: args2Role-mention-ngram: cells reducest-e1: args2Role-mention-ngram: MTH1 suppressiont6interceding-token ngrams: comprehensively addressed int,e1: ents2Label-mention-ngram: suppression int%e1: ents2Label-mention-ngram: reducest&interceding-token ngrams: at least onet%interceding-token ngrams: transformedtje1: trigger-arg-path: Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt/e2: args2Role-mention-ngram: with significantlyt-interceding-token ngrams: one study indicatestee1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt#e2: args2Role-mention-ngram: by ROSt/e2: args2Role-mention-ngram: mammary epithelialtXe2: trigger-arg-path: associated:Binding dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: significantly increased cellulartXe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with >nn Simple_chemicalt'e2: args2Role-mention-ngram: by ROS andtTe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj controllertae1: trigger-arg-path: Negative_activation >nsubj [lemma='damage'] controller:Gene_or_gene_producttXe1: trigger-arg-path: reduces:Negative_activation >nsubj controller:Gene_or_gene_productt&interceding-token ngrams: addressed intae1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn Gene_or_gene_productt.e1: args2Role-mention-ngram: cells reduces thet@e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controllert-e2: ents2Label-mention-ngram: mediated by ROSt#interceding-token ngrams: the MMP 3t1e2: ents2Label-mention-ngram: and associated witht&e2: ents2Label-mention-ngram: cellulart/e1: ents2Label-mention-ngram: in HMLE-Ras cellstdobj >nn Gene_or_gene_producttinterceding-token ngrams: issuetFe1: trigger-arg-path: reduces:Negative_activation >dobj >nn controlledt#interceding-token ngrams: phenotypetLe2: trigger-arg-path: lemmatizedTrigger=associate nsubj [lemma='damage'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with >nn theme:Simple_chemicalt(e2: ents2Label-mention-ngram: by ROS andt#interceding-token ngrams: indicatest)interceding-token ngrams: RAS transformedt^e1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='damage'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: with significantlytie1: trigger-arg-path: reduces >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt$interceding-token ngrams: , at leastt-interceding-token ngrams: transformed cells ,t,interceding-token ngrams: in RAS transformedtinterceding-token ngrams: , att&interceding-token ngrams: has not beentinterceding-token ngrams: MMPt+e2: args2Role-mention-ngram: and associatedt"e1: ents2Label-mention-ngram: fromt,e2: args2Role-mention-ngram: mediated by ROSt4e2: args2Role-mention-ngram: significantly increasedt0e1: args2Role-mention-ngram: MTH1 suppression intTe1: trigger-arg-path: reduces >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt$e2: args2Role-mention-ngram: mammaryt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt!interceding-token ngrams: . WhiletGe2: trigger-arg-path: associated:Binding >prep_with >nn Simple_chemicalt%e2: args2Role-mention-ngram: THEME intle1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn controlled:Gene_or_gene_producttPe1: trigger-arg-path: reduces:Negative_activation >dobj >nn Gene_or_gene_productt[e1: trigger-arg-path: reduces:Negative_activation >dobj >nn controlled:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=associate:Binding prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt.e2: args2Role-mention-ngram: cells is mediatedt9e1: trigger-arg-path: reduces >nsubj Gene_or_gene_productt/e1: args2Role-mention-ngram: stemming from MTH1t"e1: ents2Label-mention-ngram: MTH1toe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='damage'] Gene_or_gene_producttDe2: trigger-arg-path: associated:Binding prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltEe2: trigger-arg-path: associated >prep_with >nn theme:Simple_chemicaltie1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='damage'] controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=associate:Binding nsubj [lemma='damage'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: HMLE-Ras cells reducestwe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltLe1: trigger-arg-path: Negative_activation >nsubj [lemma='damage'] controllert^e1: trigger-arg-path: reduces >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] theme:Simple_chemicaltee1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='damage'] controllert%e2: ents2Label-mention-ngram: ROS andtUe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controller:Gene_or_gene_productt)interceding-token ngrams: study indicatest-e2: trigger-arg-path: associated nsubj controllerte1: trigger: reducest%e1: args2Role-mention-ngram: HMLE-Rast+e1: ents2Label-mention-ngram: stemming fromt0e2: args2Role-mention-ngram: and associated withtMe2: trigger-arg-path: associated:Binding >prep_with >nn theme:Simple_chemicalt.e2: ents2Label-mention-ngram: in mouse mammarytBe2: trigger-arg-path: Binding >prep_with >nn theme:Simple_chemicalt"interceding-token ngrams: at leasttUe1: trigger-arg-path: reduces >nsubj [lemma='damage'] controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: mouse mammary epithelialt4e1: ents2Label-mention-ngram: HMLE-Ras cells reducest5e1: ents2Label-mention-ngram: suppression in HMLE-RastMe2: trigger-arg-path: lemmatizedTrigger=associate prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] theme:Simple_chemicalt)e1: ents2Label-mention-ngram: in HMLE-Rastce2: trigger-arg-path: Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt(interceding-token ngrams: indicates thattinterceding-token ngrams: onet&e1: ents2Label-mention-ngram: HMLE-Rast#interceding-token ngrams: 3 inducedt"interceding-token ngrams: not beent0CSSPATH: ROOT >ccomp ++ ROOT >ccomp >dobj >rcmodt^e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj Gene_or_gene_productt5e2: ents2Label-mention-ngram: significantly increasedtue1: trigger-arg-path: Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt5e2: args2Role-mention-ngram: mouse mammary epithelialtMe1: trigger-arg-path: reduces:Negative_activation >nsubj Gene_or_gene_productt'e2: args2Role-mention-ngram: epithelialt)interceding-token ngrams: least one studytWe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn controlledtinterceding-token ngrams: Whilet*interceding-token ngrams: While this issuetCe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn controlledt+interceding-token ngrams: phenotype . Whilet0e2: args2Role-mention-ngram: epithelial cells ist0e2: ents2Label-mention-ngram: increased cellulart0e1: ents2Label-mention-ngram: stemming from MTH1t+e1: ents2Label-mention-ngram: cells reducest:e2: args2Role-mention-ngram: associated with significantlytYe2: trigger-arg-path: Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] themet5e1: args2Role-mention-ngram: CONTROLLER stemming fromt#interceding-token ngrams: least onet&e2: ents2Label-mention-ngram: cells ist&e1: args2Role-mention-ngram: from MTH1tPe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with >nn Simple_chemicalt5e2: args2Role-mention-ngram: increased cellular THEMEt/e2: ents2Label-mention-ngram: cells is mediatedt/e1: ents2Label-mention-ngram: cells reduces thetze1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt e2: args2Role-mention-ngram: ROSt;e2: ents2Label-mention-ngram: associated with significantlyt&interceding-token ngrams: . While thist-e2: args2Role-mention-ngram: epithelial cellstle2: trigger-arg-path: associated >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] theme:Simple_chemicaltie2: trigger-arg-path: Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] theme:Simple_chemicalt@e2: ents2Label-mention-ngram: increased cellular SIMPLE_CHEMICALt/e2: args2Role-mention-ngram: increased cellulart+e2: ents2Label-mention-ngram: mouse mammaryt-e2: args2Role-mention-ngram: in mouse mammarytie1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: epithelialtMe2: trigger-arg-path: Binding dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='damage'] Gene_or_gene_productt+e1: args2Role-mention-ngram: suppression intinterceding-token ngrams: MMP 3t0e2: ents2Label-mention-ngram: ROS and associatedt,interceding-token ngrams: indicates that thethe1: trigger-arg-path: reduces:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt8e2: trigger-arg-path: Binding nsubj [lemma='damage'] controller:Gene_or_gene_producttGe2: trigger-arg-path: Binding dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt/e1: trigger-arg-path: reduces >nsubj controllert*e1: args2Role-mention-ngram: stemming fromtXe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn controlled:Gene_or_gene_productt=e2: args2Role-mention-ngram: significantly increased cellulartMe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn Gene_or_gene_productt'interceding-token ngrams: issue has nottTe1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='damage'] controllert"e2: args2Role-mention-ngram: mouset interceding-token ngrams: in RASt\e2: trigger-arg-path: associated >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] themet!e1: args2Role-mention-ngram: fromt>e2: trigger-arg-path: lemmatizedTrigger=associate dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] themetFe2: trigger-arg-path: lemmatizedTrigger=associate:Binding nsubj controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: HMLE-Ras cellst$interceding-token ngrams: this issuetJe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj Gene_or_gene_producttte2: trigger-arg-path: associated:Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] theme:Simple_chemicalt0e1: args2Role-mention-ngram: CONTROLLER stemmingt#e2: ents2Label-mention-ngram: mouset4e1: args2Role-mention-ngram: suppression in HMLE-Rast(e1: args2Role-mention-ngram: in HMLE-Rast@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stemming fromte2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltme2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='level'] >nn [lemma='8-oxoguanine'] themet/e2: args2Role-mention-ngram: ROS and associatedt?interceding-tokens-full-span: phenotype . While this issue has not been comprehensively addressed in RAS transformed cells , at least one study indicates that the MMP 3 inducedt%interceding-token ngrams: phenotype .t-e2: ents2Label-mention-ngram: SHARED in mouset%e2: args2Role-mention-ngram: in mouset$e2: ents2Label-mention-ngram: by ROSt$e2: args2Role-mention-ngram: ROS andtinterceding-token ngrams: leasttye1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledtQe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='damage'] controllert/interceding-token ngrams: RAS transformed cellstJe2: trigger-arg-path: associated nsubj [lemma='damage'] Gene_or_gene_producttRe2: trigger-arg-path: associated:Binding prep_with >nn themetTe2: trigger-arg-path: lemmatizedTrigger=associate:Binding prep_with >nn themet2e1: trigger-arg-path: reduces >dobj >nn controlledt6e2: ents2Label-mention-ngram: cellular SIMPLE_CHEMICALt(e1: args2Role-mention-ngram: reduces thet'e1: ents2Label-mention-ngram: from MTH1t%e1: args2Role-mention-ngram: stemmingt.interceding-token ngrams: study indicates thatt3interceding-token ngrams: comprehensively addressedt#interceding-token ngrams: addressedt#interceding-token ngrams: issue hastBe2: trigger-arg-path: associated prep_with >nn Simple_chemicalt#interceding-token ngrams: one studyt2e1: args2Role-mention-ngram: from MTH1 suppressiontCe2: trigger-arg-path: associated:Binding nsubj [lemma='icp10pk'] themete2: args2Role-mention-ngram: 3tbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: homology 3 (t%e1: args2Role-mention-ngram: homologyt1e2: ents2Label-mention-ngram: the SHARED homologyt*e1: ents2Label-mention-ngram: SH3 ) domaint%e2: ents2Label-mention-ngram: ( SH3 )t-e1: ents2Label-mention-ngram: SHARED homologytre2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productte2: ents2Label-mention-ngram: 3t[e1: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: homologytWe2: trigger-arg-path: binds:Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: homology 3 (t[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] themetBe2: trigger-arg-path: binds:Binding >nsubj [lemma='icp10pk'] themet&e1: ents2Label-mention-ngram: homologyt:e2: trigger-arg-path: binds >dobj >nn Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binds >nsubj [lemma='icp10pk'] Gene_or_gene_producttYe1: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_producttnsubj [lemma='icp10pk'] themetQe1: trigger-arg-path: Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: ( SH3 )t&e2: ents2Label-mention-ngram: ) domaintJe2: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] themetZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] themet&e1: ents2Label-mention-ngram: ) domaint+e1: args2Role-mention-ngram: THEME homologyt,e1: args2Role-mention-ngram: homology 3 SITEt[e2: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productt,e1: args2Role-mention-ngram: THEME binds thet.e2: ents2Label-mention-ngram: binds the SHAREDt!e1: ents2Label-mention-ngram: 3 (tJe1: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] themet*e2: ents2Label-mention-ngram: SH3 ) domaintae1: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] Gene_or_gene_producttQe2: trigger-arg-path: binds:Binding >nsubj [lemma='icp10pk'] Gene_or_gene_producttYe2: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_productt!e2: ents2Label-mention-ngram: 3 (t,e2: args2Role-mention-ngram: homology 3 SITEtnsubj [lemma='icp10pk'] themet!e2: ents2Label-mention-ngram: SH3t:e1: trigger-arg-path: binds >nsubj [lemma='icp10pk'] themetae1: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productt@e2: trigger-arg-path: binds >dobj >nn theme:Gene_or_gene_producttae2: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED homology 3tBe2: trigger-arg-path: binds:Binding >dobj >nn Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] themet(e2: ents2Label-mention-ngram: homology 3t_e1: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttae2: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_productt-e2: args2Role-mention-ngram: THEME homology 3t/e1: args2Role-mention-ngram: the THEME homologyt#e1: ents2Label-mention-ngram: SH3 )t'e2: args2Role-mention-ngram: homology 3tSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] themet.e1: ents2Label-mention-ngram: binds the SHAREDt#e1: ents2Label-mention-ngram: ( SH3tOe1: trigger-arg-path: binds >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: binds the THEMEt'e2: ents2Label-mention-ngram: binds thet#e2: ents2Label-mention-ngram: SH3 )t,e2: args2Role-mention-ngram: THEME binds thetge2: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttIe1: trigger-arg-path: binds >nsubj [lemma='icp10pk'] Gene_or_gene_producttWe1: trigger-arg-path: binds:Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] themet.e2: ents2Label-mention-ngram: SHARED binds thet`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] themetQe1: trigger-arg-path: binds:Binding >nsubj [lemma='icp10pk'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: homology 3tje2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] themetOe2: trigger-arg-path: binds >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED homologyt#e2: ents2Label-mention-ngram: ( SH3t&e2: args2Role-mention-ngram: binds thet/e2: ents2Label-mention-ngram: SHARED homology 3tge1: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: binds thet1e1: ents2Label-mention-ngram: the SHARED homologytQe2: trigger-arg-path: Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: homology 3t-e1: args2Role-mention-ngram: THEME homology 3tKe1: trigger-arg-path: Binding >nsubj [lemma='icp10pk'] Gene_or_gene_productt:e2: trigger-arg-path: binds >nsubj [lemma='icp10pk'] themetxe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] themet/e2: args2Role-mention-ngram: the THEME homologytLe2: trigger-arg-path: Binding >dobj [lemma='domain'] >nn [lemma='src'] themet_e2: trigger-arg-path: binds >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: 3 ( SH3t.e1: ents2Label-mention-ngram: SHARED binds thet,e2: args2Role-mention-ngram: binds the THEMEt#e1: args2Role-mention-ngram: 3 SITEtKe2: trigger-arg-path: Binding >nsubj [lemma='icp10pk'] Gene_or_gene_productt%e2: args2Role-mention-ngram: homologytbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='icp10pk'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] Gene_or_gene_producttHe2: trigger-arg-path: binds:Binding >dobj >nn theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: 3 SITEt+e2: args2Role-mention-ngram: THEME homologytSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='icp10pk'] themet[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] themetRe1: trigger-arg-path: binds:Binding >dobj [lemma='domain'] >nn [lemma='src'] themetpe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='domain'] >nn [lemma='src'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: 3 ( SH3t?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT versus othertTe1: trigger-arg-path: Binding >prep_between [lemma='raf'] theme:Gene_or_gene_producttme1: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] SitetSe1: trigger-arg-path: interactions >prep_between [lemma='raf'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet7e1: trigger-arg-path: Binding >prep >pobj >nn site:Sitet1e1: ents2Label-mention-ngram: versus other GTPaset7e1: trigger-arg-path: interactions >prep >pobj >nn Sitet[e1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] Gene_or_gene_productt-e1: args2Role-mention-ngram: other GTPase andtqinterceding-tokens-full-span: pairs has also not yet been determined . Given that it is presently unclear whethertae1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] theme:Gene_or_gene_producttee1: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet*e1: ents2Label-mention-ngram: other GTPasetDe1: trigger-arg-path: interactions:Binding >prep >pobj >nn site:Sitetve1: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitetDe1: trigger-arg-path: interactions >prep_between [lemma='raf'] themet=e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT versust,e1: ents2Label-mention-ngram: GTPase and RBDt%e1: ents2Label-mention-ngram: and RBDtle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] Gene_or_gene_productt/e1: args2Role-mention-ngram: THEME versus othert`e1: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet2e1: trigger-arg-path: Binding >prep >pobj >nn sitet0e1: args2Role-mention-ngram: versus other GTPaset?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet-e1: args2Role-mention-ngram: and THEME versustHe1: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn sitetje1: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:SitetRCSSPATH: ROOT >conj_but >nsubjpass >prep_of >vmod >dobj ++ ROOT >dep >pcomp >ccomptMe1: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn site:Sitet)e1: args2Role-mention-ngram: versus othert`e1: trigger-arg-path: Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitetje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: GTPase andt2e1: trigger-arg-path: Binding >prep >pobj >nn Sitet~e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet(e1: ents2Label-mention-ngram: GTPase andtNe1: trigger-arg-path: Binding >prep_between [lemma='raf'] Gene_or_gene_producttprep >pobj >nn site:Sitet]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] themetYe1: trigger-arg-path: interactions >prep_between [lemma='raf'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=interaction >prep >pobj >nn SitetLe1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf'] themetve1: trigger-arg-path: lemmatizedTrigger=interaction >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitetde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] Gene_or_gene_producttee1: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet?e1: trigger-arg-path: interactions:Binding >prep >pobj >nn sitet9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT versust?e1: trigger-arg-path: Binding >prep_between [lemma='raf'] themet)e1: args2Role-mention-ngram: THEME versust~e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] SitetUe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn site:SitetPe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn sitetme1: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] sitet.e1: ents2Label-mention-ngram: other GTPase andtre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: GTPase and SITEt!e1: ents2Label-mention-ngram: RBDtUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf'] themet?e1: trigger-arg-path: interactions:Binding >prep >pobj >nn Sitetee1: trigger-arg-path: interactions >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] Sitet7e1: trigger-arg-path: interactions >prep >pobj >nn sitetre1: trigger-arg-path: interactions:Binding >prep [lemma='versus'] >pobj [lemma='pair'] >nn [lemma='rbd'] site:Sitet*e1: ents2Label-mention-ngram: versus othert)e1: args2Role-mention-ngram: other GTPasetPe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep >pobj >nn Sitet;e2: ents2Label-mention-ngram: promotes GENE_OR_GENE_PRODUCTtRe1: trigger-arg-path: binds:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] FamilytGe2: trigger-arg-path: promotes:Positive_activation >dobj >nn controlledt{e2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='bax'] >nn [lemma='bcl-2'] Familytge2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='bax'] controlledtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] themet$e1: args2Role-mention-ngram: ( Bif-1t|e2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='bax'] controlled:Gene_or_gene_productt?e2: args2Role-mention-ngram: CONTROLLER overexpression promotest`e2: trigger-arg-path: promotes >dobj [lemma='activation'] >nn [lemma='bax'] Gene_or_gene_productt>e2: trigger-arg-path: promotes >nsubj >nn Gene_or_gene_productt/e1: args2Role-mention-ngram: proapoptotic THEMEtxe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT overexpressiontJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] themetIe1: trigger-arg-path: binds >dobj [lemma='bax'] >nn [lemma='bcl-2'] themetQe1: trigger-arg-path: binds:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] themetNe1: trigger-arg-path: binds >nsubj [lemma='factor'] theme:Gene_or_gene_productt4e2: args2Role-mention-ngram: overexpression promotestJe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT overexpression promotestJe2: ents2Label-mention-ngram: overexpression promotes GENE_OR_GENE_PRODUCTt2interceding-tokens-full-span: family protein Bax .t?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: Bif-1 ) bindst?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] Gene_or_gene_productt3e1: args2Role-mention-ngram: binds the proapoptotictke2: trigger-arg-path: promotes >dobj [lemma='activation'] >nn [lemma='bax'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] Familyt$e1: args2Role-mention-ngram: Bif-1 )t%e1: ents2Label-mention-ngram: Bif-1 )t%e1: ents2Label-mention-ngram: ( Bif-1t4e1: ents2Label-mention-ngram: binds the proapoptotict_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] themette2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlled:Gene_or_gene_producttPe1: trigger-arg-path: Binding >nsubj [lemma='factor'] theme:Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='bax'] >nn [lemma='bcl-2'] Familyt'e1: ents2Label-mention-ngram: ( Bif-1 )tce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj >nn Gene_or_gene_producttQe2: trigger-arg-path: promotes:Positive_activation >dobj >nn Gene_or_gene_productt}e2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: Bif-1t{e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlledt6e2: args2Role-mention-ngram: CONTROLLER overexpressiont#e1: ents2Label-mention-ngram: Bif-1t;e1: trigger-arg-path: Binding >nsubj [lemma='factor'] themetinterceding-token ngrams: BaxtTe2: trigger-arg-path: Positive_activation >nsubj >nn controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: ) binds thetHe1: trigger-arg-path: binds >nsubj [lemma='factor'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: the proapoptotict%interceding-token ngrams: protein Baxt5e2: ents2Label-mention-ngram: overexpression promotest5e1: ents2Label-mention-ngram: the proapoptotic FAMILYtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] Familytae1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='bax'] >nn [lemma='bcl-2'] theme:FamilytOe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn Gene_or_gene_productt interceding-token ngrams: familytAe1: trigger-arg-path: binds:Binding >nsubj [lemma='factor'] themetXe1: trigger-arg-path: binds:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] theme:FamilytJe1: trigger-arg-path: Binding >nsubj [lemma='factor'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activation'] >nn [lemma='bax'] Gene_or_gene_productthe2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controllertYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj >nn controllertbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] themet1e1: ents2Label-mention-ngram: proapoptotic FAMILYt'interceding-token ngrams: protein Bax .t*e1: args2Role-mention-ngram: Bif-1 ) bindste2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlled:Gene_or_gene_producttRe1: trigger-arg-path: Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] theme:FamilytHe2: trigger-arg-path: promotes:Positive_activation >nsubj >nn controllertre2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] Gene_or_gene_producttve2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: ) binds thet-e1: args2Role-mention-ngram: the proapoptotict\e2: trigger-arg-path: promotes:Positive_activation >dobj >nn controlled:Gene_or_gene_producttae2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controller:Gene_or_gene_productt]e2: trigger-arg-path: promotes:Positive_activation >nsubj >nn controller:Gene_or_gene_producttke2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn controller:Gene_or_gene_productt9e1: trigger-arg-path: binds >nsubj [lemma='factor'] themetIe2: trigger-arg-path: Positive_activation >nsubj >nn Gene_or_gene_producttqe2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controllert,e2: ents2Label-mention-ngram: overexpressiontYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] Gene_or_gene_productt+e2: args2Role-mention-ngram: overexpressiont4e2: trigger-arg-path: promotes >nsubj >nn controllert)e1: args2Role-mention-ngram: proapoptotictVe2: trigger-arg-path: promotes >dobj [lemma='activation'] >nn [lemma='bax'] controlledtne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] Gene_or_gene_productt?e2: args2Role-mention-ngram: overexpression promotes CONTROLLEDtZe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='bax'] >nn [lemma='bcl-2'] themetge2: trigger-arg-path: promotes >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] Gene_or_gene_producttRe2: trigger-arg-path: promotes:Positive_activation >nsubj >nn Gene_or_gene_producttre2: trigger-arg-path: promotes >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controller:Gene_or_gene_productt]e2: trigger-arg-path: promotes >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controllert(interceding-token ngrams: family proteint,interceding-token ngrams: family protein BaxtVe1: trigger-arg-path: binds:Binding >nsubj [lemma='factor'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: 1 ( Bif-1tinterceding-token ngrams: Bax .t&e1: args2Role-mention-ngram: THEME 1 (tje2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activation'] >nn [lemma='bax'] controlledtie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='bax'] >nn [lemma='bcl-2'] theme:Familytne2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controllertPe1: trigger-arg-path: binds:Binding >nsubj [lemma='factor'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: 1 ( Bif-1tPe1: trigger-arg-path: binds >dobj [lemma='bax'] >nn [lemma='bcl-2'] theme:FamilytEe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn controllert&e1: args2Role-mention-ngram: ( Bif-1 )t?e2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='overexpression'] >nn [lemma='Bif-1'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: proapoptotictIe2: trigger-arg-path: promotes >nsubj >nn controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: the proapoptotic THEMEt3e1: args2Role-mention-ngram: transcription functiontYe1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_of themet5e1: trigger-arg-path: binding >prep_of >prep_of themet=e1: trigger-arg-path: binding:Binding >prep_of >prep_of themetne1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] themet.e1: args2Role-mention-ngram: a transcriptionaltGe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_of themetJe1: trigger-arg-path: binding >prep_of >prep_of theme:Gene_or_gene_producttke1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] Gene_or_gene_productt6e1: args2Role-mention-ngram: transcriptional regulatortqe1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: MAZt'e1: args2Role-mention-ngram: factor , at.e1: args2Role-mention-ngram: and transcriptiontQe1: trigger-arg-path: Binding >prep_of [lemma='saf-1'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] themet4e2: ents2Label-mention-ngram: FAMILY gene expressiontce1: trigger-arg-path: Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] Gene_or_gene_productt\e1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] themet]e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] Gene_or_gene_productt.e1: args2Role-mention-ngram: MAZ transcriptiont(e1: args2Role-mention-ngram: THEME / MAZtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_of theme:Gene_or_gene_producttDe1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] themetNe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] themetVe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_of Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: , a transcriptionaltie1: trigger-arg-path: binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] theme:Gene_or_gene_producttprep_of [lemma='saf-1'] themet&e1: args2Role-mention-ngram: regulatortLe1: trigger-arg-path: binding:Binding >prep_of >prep_of Gene_or_gene_productt)e2: ents2Label-mention-ngram: FAMILY genetce1: trigger-arg-path: binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] theme:Gene_or_gene_producttie1: trigger-arg-path: Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: function of THEMEtke1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] theme:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] Gene_or_gene_productt7e1: args2Role-mention-ngram: and transcription functiont5e1: args2Role-mention-ngram: MAZ transcription factort^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_of Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] themet(e1: args2Role-mention-ngram: function oftSe1: trigger-arg-path: binding:Binding >prep_of [lemma='saf-1'] Gene_or_gene_productt'CSSPATH: ROOT >dobj ++ ROOT >dobj >vmodtDe1: trigger-arg-path: binding >prep_of >prep_of Gene_or_gene_productte1: args2Role-mention-ngram: /tee1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] Gene_or_gene_productt'e1: args2Role-mention-ngram: of THEME /t\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_of theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: / MAZ transcriptiont6e1: args2Role-mention-ngram: transcription function oftKe1: trigger-arg-path: Binding >prep_of [lemma='saf-1'] Gene_or_gene_producttTe1: trigger-arg-path: binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] themet/e1: args2Role-mention-ngram: regulator of THEMEtKe1: trigger-arg-path: binding >prep_of [lemma='saf-1'] Gene_or_gene_productt6e1: args2Role-mention-ngram: binding and transcriptiont)e1: args2Role-mention-ngram: regulator oft8e1: args2Role-mention-ngram: a transcriptional regulatort?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] >prep_of [lemma='vegf'] theme:Gene_or_gene_productt9e1: args2Role-mention-ngram: transcriptional regulator oftQe1: trigger-arg-path: binding >prep_of [lemma='saf-1'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: transcription factor ,tprep_of [lemma='saf-1'] themet$e1: args2Role-mention-ngram: THEME /t"e1: args2Role-mention-ngram: / MAZtRe1: trigger-arg-path: binding:Binding >prep_of >prep_of theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='saf-1'] themetSe2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] themetLe2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Hoxb-13'] themetnsubj [lemma='Hoxb-13'] themetOe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Hoxb-13'] themet-interceding-token ngrams: for full activationtinterceding-token ngrams: somet,interceding-token ngrams: activation of sometme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] themetEe2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] themet"interceding-token ngrams: , and istLe2: trigger-arg-path: Binding:Binding >prep_of >prep_to Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] theme:Gene_or_gene_producttTe2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] Gene_or_gene_productt4e2: trigger-arg-path: Binding:Binding >prep_of themet0interceding-token ngrams: regulated target genest?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] theme:Gene_or_gene_producttEe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ar'] themetde2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Hoxb-13'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] Gene_or_gene_productte2: trigger: Bindingt$e2: args2Role-mention-ngram: BindingtOe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] themet'interceding-token ngrams: some androgentIe2: trigger-arg-path: Binding:Binding >prep_of theme:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] theme:Gene_or_gene_productt"interceding-token ngrams: androgent^e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] Gene_or_gene_productt!interceding-token ngrams: of somet(interceding-token ngrams: target genes .tLe1: trigger-arg-path: interacts >prep_with [lemma='ar'] Gene_or_gene_producttRe2: trigger-arg-path: Binding:Binding >prep_of >prep_to theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >nsubj [lemma='Hoxb-13'] themetUe1: trigger-arg-path: interacts:Binding >nsubj [lemma='Hoxb-13'] Gene_or_gene_productt,interceding-token ngrams: androgen regulatedt3interceding-token ngrams: androgen regulated targettRe1: trigger-arg-path: interacts >prep_with [lemma='ar'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >nsubj [lemma='Hoxb-13'] theme:Gene_or_gene_productt!interceding-token ngrams: genes .t,interceding-token ngrams: full activation oft>e1: trigger-arg-path: interacts >nsubj [lemma='Hoxb-13'] themetZe2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] themetee2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] themet[e1: trigger-arg-path: interacts:Binding >nsubj [lemma='Hoxb-13'] theme:Gene_or_gene_producttbe2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] Gene_or_gene_productt)interceding-token ngrams: full activationtKe1: trigger-arg-path: Binding >nsubj [lemma='Hoxb-13'] Gene_or_gene_productt*interceding-token ngrams: regulated targett|e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] Gene_or_gene_producttinterceding-token ngrams: fulltje2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] Gene_or_gene_productt=e1: trigger-arg-path: interacts >prep_with [lemma='ar'] themet*interceding-token ngrams: of some androgentTe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ar'] Gene_or_gene_productt1interceding-token ngrams: some androgen regulatedt/e2: ents2Label-mention-ngram: Binding of SHAREDtle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Hoxb-13'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding:Binding >prep_of >prep_to themet-e2: args2Role-mention-ngram: Binding of THEMEthe2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] theme:Gene_or_gene_productt)interceding-token ngrams: and is requiredt[e2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] themetZe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ar'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Hoxb-13'] theme:Gene_or_gene_productt"interceding-token ngrams: for fulltSe1: trigger-arg-path: interacts >nsubj [lemma='Hoxb-13'] theme:Gene_or_gene_producttCe2: trigger-arg-path: Binding:Binding >prep_of Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Hoxb-13'] Gene_or_gene_producttMe1: trigger-arg-path: interacts >nsubj [lemma='Hoxb-13'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: Binding oft+interceding-token ngrams: required for fullt&interceding-token ngrams: target genest%e2: ents2Label-mention-ngram: Bindingtminterceding-tokens-full-span: , and is required for full activation of some androgen regulated target genes .tpe2: trigger-arg-path: Binding:Binding >prep_of [lemma='hoxb13'] >prep_to [lemma='ar'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_of [lemma='hoxb13'] themet'e2: args2Role-mention-ngram: Binding oft;e2: ents2Label-mention-ngram: enhances GENE_OR_GENE_PRODUCTt^e2: trigger-arg-path: Positive_activation >nsubj [lemma='yy1'] controller:Gene_or_gene_productt/interceding-token ngrams: thereby impairing p53t interceding-token ngrams: p300 ,tSe2: trigger-arg-path: Positive_activation >nsubj [lemma='yy1'] Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='p53'] theme:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] Gene_or_gene_producttpe2: trigger-arg-path: Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] Gene_or_gene_productt5e1: trigger-arg-path: binds >dobj [lemma='p53'] themet?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlled:Gene_or_gene_productt'interceding-token ngrams: impairing p53tRe2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='yy1'] controllert)interceding-token ngrams: p53 acetylationtNe2: trigger-arg-path: enhances:Positive_activation >nsubj Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='yy1'] Gene_or_gene_productt*interceding-token ngrams: association witht%interceding-token ngrams: acetylationt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlledtle2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlledtoe2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlledtLe1: trigger-arg-path: binds:Binding >nsubj [lemma='it'] theme:Generic_entityt(interceding-token ngrams: p300 , therebyt@e2: ents2Label-mention-ngram: also enhances GENE_OR_GENE_PRODUCTtYe2: trigger-arg-path: enhances:Positive_activation >nsubj controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj Gene_or_gene_producttSe2: trigger-arg-path: enhances >nsubj [lemma='yy1'] controller:Gene_or_gene_productt!interceding-token ngrams: for itst5e1: trigger-arg-path: binds >nsubj [lemma='it'] themetce2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='yy1'] controllert>e1: trigger-arg-path: binds >nsubj [lemma='it'] Generic_entitytninterceding-tokens-full-span: and competes for its association with p300 , thereby impairing p53 acetylation .t*interceding-token ngrams: competes for itst1e1: trigger-arg-path: binds >nsubj Generic_entitytDe1: trigger-arg-path: binds >nsubj [lemma='it'] theme:Generic_entityt\e2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='yy1'] Gene_or_gene_productt)interceding-token ngrams: its associationtFe1: trigger-arg-path: binds:Binding >nsubj [lemma='it'] Generic_entitytIe2: trigger-arg-path: Positive_activation >nsubj [lemma='yy1'] controllertde2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='yy1'] controller:Gene_or_gene_producttge2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='yy1'] controller:Gene_or_gene_productt=e1: trigger-arg-path: binds:Binding >dobj [lemma='p53'] themet%interceding-token ngrams: with p300 ,tLe1: trigger-arg-path: binds:Binding >dobj [lemma='p53'] Gene_or_gene_productt[e2: trigger-arg-path: enhances >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlledt+interceding-token ngrams: thereby impairingtUe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj controllertHe2: trigger-arg-path: enhances >nsubj [lemma='yy1'] Gene_or_gene_productt7e1: trigger-arg-path: binds >nsubj theme:Generic_entityt?e2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlled:Gene_or_gene_productt'interceding-token ngrams: acetylation .tRe1: trigger-arg-path: binds:Binding >dobj [lemma='p53'] theme:Gene_or_gene_producttye2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] Gene_or_gene_productt.interceding-token ngrams: its association withtDe1: trigger-arg-path: binds >dobj [lemma='p53'] Gene_or_gene_productt>e2: trigger-arg-path: enhances >nsubj [lemma='yy1'] controllert3interceding-token ngrams: impairing p53 acetylationt=e1: trigger-arg-path: binds:Binding >nsubj [lemma='it'] themetOe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='yy1'] controllert2e2: ents2Label-mention-ngram: SHARED also enhancest"interceding-token ngrams: competest9e1: trigger-arg-path: binds:Binding >nsubj Generic_entityt?e1: trigger-arg-path: binds:Binding >nsubj theme:Generic_entityt*interceding-token ngrams: and competes fort?e2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlled:Gene_or_gene_producttpe2: trigger-arg-path: enhances >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlled:Gene_or_gene_productt!interceding-token ngrams: therebytDe2: trigger-arg-path: enhances:Positive_activation >nsubj controllertme2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='yy1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] Gene_or_gene_productt-interceding-token ngrams: for its associationt:e2: trigger-arg-path: enhances >nsubj Gene_or_gene_productt#interceding-token ngrams: , therebytxe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='yy1'] controller:Gene_or_gene_productt+interceding-token ngrams: p53 acetylation .t#interceding-token ngrams: impairingt/interceding-token ngrams: association with p300tEe2: trigger-arg-path: enhances >nsubj controller:Gene_or_gene_productt0e2: trigger-arg-path: enhances >nsubj controllert&interceding-token ngrams: and competest&interceding-token ngrams: competes fort-interceding-token ngrams: , thereby impairingtee2: trigger-arg-path: enhances >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] Gene_or_gene_productt{e2: trigger-arg-path: Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlled:Gene_or_gene_producttfe2: trigger-arg-path: Positive_activation >dobj [lemma='ubiquitylation'] >nn [lemma='mdm2'] controlledtje2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj controller:Gene_or_gene_productt\e2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='mitogen'] controllertne2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='mitogen'] controller:Gene_or_gene_producttMe2: trigger-arg-path: Positive_regulation >agent [lemma='mitogen'] controllert?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='mapk'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass Gene_or_gene_producttCe1: trigger-arg-path: Positive_activation agent controllertKe2: trigger-arg-path: phosphorylated >agent controller:Gene_or_gene_productt?e1: trigger-arg-path: directly activated:Positive_activation nsubjpass [lemma='eif4e'] Gene_or_gene_productt6e2: trigger-arg-path: phosphorylated >agent controllert?e1: trigger-arg-path: directly activated:Positive_activation agent [lemma='mapk'] Gene_or_gene_producttHe2: trigger-arg-path: phosphorylated >agent [lemma='mitogen'] controllertde1: trigger-arg-path: directly activated:Positive_activation nsubjpass Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent controller:Gene_or_gene_producttoe1: trigger-arg-path: Positive_activation agent [lemma='mapk'] Gene_or_gene_productt)e1: args2Role-mention-ngram: not directlyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent [lemma='mapk'] Gene_or_gene_producttRe2: trigger-arg-path: phosphorylated >agent [lemma='mitogen'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass controlledtze1: trigger-arg-path: Positive_activation agent [lemma='mapk'] controller:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent controllert_e2: trigger-arg-path: phosphorylated:Positive_regulation >agent controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='mitogen'] controllertMe1: trigger-arg-path: Positive_activation agent Gene_or_gene_producttGe1: trigger-arg-path: Positive_activation nsubjpass controlledtfe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='mitogen'] Gene_or_gene_producttZe1: trigger-arg-path: directly activated:Positive_activation nsubjpass controlledt\e1: trigger-arg-path: Positive_activation nsubjpass controlled:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=directly activate agent controller:Gene_or_gene_producttWe1: trigger-arg-path: directly activated agent controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: is not directlytae1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass Gene_or_gene_producttTe2: trigger-arg-path: phosphorylated:Positive_regulation >agent Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='mitogen'] controllertye1: trigger-arg-path: directly activated agent [lemma='mapk'] controller:Gene_or_gene_producttde1: trigger-arg-path: directly activated agent [lemma='mapk'] controllert4e1: ents2Label-mention-ngram: not directly activatedtbe2: trigger-arg-path: Positive_regulation >agent [lemma='mitogen'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass [lemma='eif4e'] Gene_or_gene_producttBe1: trigger-arg-path: directly activated agent controllertee2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent Gene_or_gene_producttoe1: trigger-arg-path: directly activated:Positive_activation nsubjpass controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent [lemma='mapk'] controller:Gene_or_gene_productt#interceding-token ngrams: ERK . Thet.e1: args2Role-mention-ngram: CONTROLLED is nott?e1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='eif4e'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent [lemma='mapk'] controllertQe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent Gene_or_gene_productt`e1: trigger-arg-path: directly activated:Positive_activation agent Gene_or_gene_productt+e2: ents2Label-mention-ngram: SHARED can betGe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent controllertXe1: trigger-arg-path: Positive_activation agent controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent controller:Gene_or_gene_producttQe1: trigger-arg-path: Positive_activation nsubjpass Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass controlled:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='mapk'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=directly activate agent controllertJe2: trigger-arg-path: phosphorylated:Positive_regulation >agent controllertinterceding-token ngrams: ERK .tWe2: trigger-arg-path: Positive_regulation >agent [lemma='mitogen'] Gene_or_gene_productt?e1: trigger-arg-path: directly activated:Positive_activation agent [lemma='mapk'] controller:Gene_or_gene_producttPe1: trigger-arg-path: directly activated nsubjpass Gene_or_gene_productt8e2: ents2Label-mention-ngram: directly phosphorylated byt?e1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='eif4e'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: directly activated agent Gene_or_gene_productt~e1: trigger-arg-path: directly activated nsubjpass [lemma='eif4e'] controlled:Gene_or_gene_productt*e1: ents2Label-mention-ngram: not directlyte2: trigger: phosphorylatedtwe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='mitogen'] Gene_or_gene_producttVe1: trigger-arg-path: directly activated:Positive_activation agent controllertDe2: ents2Label-mention-ngram: phosphorylated by GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass [lemma='eif4e'] controlledtse1: trigger-arg-path: directly activated nsubjpass [lemma='eif4e'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=directly activate agent Gene_or_gene_productt@e2: trigger-arg-path: phosphorylated >agent Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='mitogen'] Gene_or_gene_productte1: trigger-arg-path: Positive_activation nsubjpass [lemma='eif4e'] controlled:Gene_or_gene_productt}e1: trigger-arg-path: directly activated:Positive_activation nsubjpass [lemma='eif4e'] controlledtze1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='eif4e'] controlledt?e1: trigger-arg-path: directly activated:Positive_activation nsubjpass [lemma='eif4e'] controlled:Gene_or_gene_producttqe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='mitogen'] controller:Gene_or_gene_producttie1: trigger-arg-path: directly activated nsubjpass [lemma='eif4e'] controlledt#interceding-token ngrams: and ERK .t-e1: ents2Label-mention-ngram: is not directlyt]e2: trigger-arg-path: phosphorylated >agent [lemma='mitogen'] controller:Gene_or_gene_producttee1: trigger-arg-path: Positive_activation agent [lemma='mapk'] controllertke1: trigger-arg-path: directly activated:Positive_activation agent controller:Gene_or_gene_producttte1: trigger-arg-path: Positive_activation nsubjpass [lemma='eif4e'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='mitogen'] controller:Gene_or_gene_producttFe1: trigger-arg-path: directly activated nsubjpass controlledtpe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent controller:Gene_or_gene_producttxe1: trigger-arg-path: directly activated:Positive_activation agent [lemma='mapk'] controllert[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent controllert?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass [lemma='eif4e'] controlled:Gene_or_gene_producttje1: trigger-arg-path: Positive_activation nsubjpass [lemma='eif4e'] controlledtke1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation nsubjpass controlledtne1: trigger-arg-path: directly activated agent [lemma='mapk'] Gene_or_gene_productt[e1: trigger-arg-path: directly activated nsubjpass controlled:Gene_or_gene_productt+e1: ents2Label-mention-ngram: SHARED is nottue1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='mapk'] controllert3e1: args2Role-mention-ngram: not directly activatedt5e2: ents2Label-mention-ngram: directly phosphorylatedt)e2: ents2Label-mention-ngram: be directlyt-e2: ents2Label-mention-ngram: can be directlyt8e2: ents2Label-mention-ngram: be directly phosphorylatedt+interceding-tokens-full-span: and ERK . Thetqe1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_activation agent Gene_or_gene_producttCe1: trigger-arg-path: produce >dobj [lemma='ra'] controlled:BindingtYe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='gap'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >dobj [lemma='ra'] BindingtAe1: trigger-arg-path: Positive_regulation dobj controlledt;e1: trigger-arg-path: produce dobj Bindingt]e1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation nsubj [lemma='gap'] controller:Gene_or_gene_productt%interceding-token ngrams: GDP therebyt?e1: args2Role-mention-ngram: produce nucleotide-free CONTROLLEDt;e1: trigger-arg-path: produce >dobj [lemma='ra'] controlledt9e1: ents2Label-mention-ngram: FAMILY which preferentiallytBe1: trigger-arg-path: Positive_regulation >dobj controlled:Bindingt&e2: args2Role-mention-ngram: intrinsict2e1: ents2Label-mention-ngram: preferentially bindst@e1: trigger-arg-path: lemmatizedTrigger=produce >dobj controlledtme2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='gap'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='gap'] controller:Gene_or_gene_productt7e1: trigger-arg-path: produce nsubj controller:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhance thet#e2: args2Role-mention-ngram: of RastJe1: trigger-arg-path: lemmatizedTrigger=produce >dobj [lemma='ra'] Bindingthe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation dobj [lemma='ra'] controlledt:e1: ents2Label-mention-ngram: nucleotide-free FAMILY whichtOe1: trigger-arg-path: produce:Positive_regulation >dobj [lemma='ra'] controlledt8interceding-token ngrams: higher cellular concentrationstGe1: trigger-arg-path: Positive_regulation >dobj [lemma='ra'] controlledt7e1: trigger-arg-path: Positive_regulation >dobj Bindingt$interceding-token ngrams: the highert/interceding-token ngrams: concentrations of GTPtIe1: trigger-arg-path: produce:Positive_regulation nsubj controller:Gene_or_gene_productt.e1: trigger-arg-path: produce dobj controlledt6e1: trigger-arg-path: produce >dobj controlled:BindingtUe1: trigger-arg-path: lemmatizedTrigger=produce >dobj [lemma='ra'] controlled:BindingtIe1: trigger-arg-path: lemmatizedTrigger=produce nsubj controllert\e1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >dobj controlled:Bindingt)interceding-token ngrams: higher cellulart.e1: trigger-arg-path: produce >dobj controlledt,e1: ents2Label-mention-ngram: preferentiallyt6e1: trigger-arg-path: Positive_regulation dobj [lemma='ra'] BindingtQe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >dobj BindingtCe1: trigger-arg-path: Positive_regulation nsubj [lemma='gap'] Gene_or_gene_productt1e2: args2Role-mention-ngram: the intrinsic GTPaset[e2: trigger-arg-path: enhance:Positive_regulation >nsubj [lemma='gap'] Gene_or_gene_productt(interceding-token ngrams: concentrationst7e2: ents2Label-mention-ngram: intrinsic GTPase activityt>e1: trigger-arg-path: produce:Positive_regulation nsubj [lemma='gap'] controller:Gene_or_gene_productt*e1: trigger-arg-path: produce dobj controlled:BindingtKe1: trigger-arg-path: produce:Positive_regulation nsubj [lemma='gap'] controllert/e2: ents2Label-mention-ngram: to facilitate thet4interceding-token ngrams: cellular concentrations oft7e1: args2Role-mention-ngram: to produce nucleotide-freet(e2: ents2Label-mention-ngram: facilitatet*e2: args2Role-mention-ngram: the intrinsictMe2: trigger-arg-path: enhance:Positive_regulation >nsubj Gene_or_gene_productt9e2: trigger-arg-path: enhance >nsubj Gene_or_gene_productt'e2: args2Role-mention-ngram: facilitatet(e1: ents2Label-mention-ngram: to producet*e1: ents2Label-mention-ngram: FAMILY whicht$e2: ents2Label-mention-ngram: Ras tot+e1: trigger-arg-path: produce >dobj Bindingt-interceding-token ngrams: GDP thereby leadingt3e2: ents2Label-mention-ngram: enhance the intrinsict+e2: ents2Label-mention-ngram: to facilitatetie1: trigger-arg-path: lemmatizedTrigger=produce:Positive_regulation >dobj [lemma='ra'] controlled:Bindingt/e2: args2Role-mention-ngram: CONTROLLER enhancet&interceding-token ngrams: GTP over GDPt&e2: args2Role-mention-ngram: of Ras tot+interceding-token ngrams: concentrations oftQe2: trigger-arg-path: enhance:Positive_regulation >nsubj [lemma='gap'] controllert interceding-token ngrams: of GTPt8e1: ents2Label-mention-ngram: to produce nucleotide-freet4e1: args2Role-mention-ngram: produce nucleotide-freetJe1: trigger-arg-path: produce:Positive_regulation >dobj controlled:BindingtLe1: trigger-arg-path: produce:Positive_regulation >dobj [lemma='ra'] Bindingt+e2: ents2Label-mention-ngram: the intrinsict"interceding-token ngrams: GTP overt'e1: args2Role-mention-ngram: to producetIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='gap'] controllert.e2: args2Role-mention-ngram: Ras to facilitatetGe2: trigger-arg-path: enhance >nsubj [lemma='gap'] Gene_or_gene_productt8e1: trigger-arg-path: produce >dobj [lemma='ra'] Bindingtfe2: trigger-arg-path: enhance:Positive_regulation >nsubj [lemma='gap'] controller:Gene_or_gene_productt'CSSPATH: ROOT >prep_from >vmod ++ ROOT t interceding-token ngrams: due tot-e2: ents2Label-mention-ngram: activity of Rast#e2: args2Role-mention-ngram: Ras totOe1: trigger-arg-path: Positive_regulation >dobj [lemma='ra'] controlled:Bindingt interceding-token ngrams: to Rast%interceding-token ngrams: of GTP overtinterceding-token ngrams: duet-e2: ents2Label-mention-ngram: GTPase activitytnsubj [lemma='gap'] controllertCe2: trigger-arg-path: enhance:Positive_regulation >nsubj controllert7e1: args2Role-mention-ngram: nucleotide-free CONTROLLEDt3e2: args2Role-mention-ngram: CONTROLLER enhance thet8e1: ents2Label-mention-ngram: which preferentially bindst,e2: ents2Label-mention-ngram: the hydrolysist$interceding-token ngrams: due to thetOe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='gap'] controllert,e2: args2Role-mention-ngram: GTPase activityt(interceding-token ngrams: leading to RastMe1: trigger-arg-path: lemmatizedTrigger=produce >dobj [lemma='ra'] controlledt)interceding-token ngrams: activation . Int$e2: ents2Label-mention-ngram: of RastWe1: trigger-arg-path: produce:Positive_regulation >dobj [lemma='ra'] controlled:Bindingt/e1: ents2Label-mention-ngram: FAMILY to producet"interceding-token ngrams: cellulart=e1: trigger-arg-path: lemmatizedTrigger=produce >dobj Bindingt'interceding-token ngrams: to the highert2e1: args2Role-mention-ngram: CONTROLLER to producet%e1: ents2Label-mention-ngram: producet$e1: args2Role-mention-ngram: producet2e2: args2Role-mention-ngram: enhance the intrinsict:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhancet1interceding-token ngrams: cellular concentrationstde2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='gap'] controller:Gene_or_gene_productt&interceding-token ngrams: disrupts thet,interceding-token ngrams: SIRT1 disrupts thet.interceding-token ngrams: deacetylase activitytee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sirt1'] Gene_or_gene_productt+interceding-token ngrams: of the N-terminaltne2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='p53'] themetprep_of [lemma='sirt1'] themetTe2: trigger-arg-path: Binding prep_with [lemma='p53'] themet0interceding-token ngrams: affects directly SIRT1tYe2: trigger-arg-path: binding:Binding >prep_of [lemma='sirt1'] theme:Gene_or_gene_productt!interceding-token ngrams: affectst$interceding-token ngrams: and Lys238t2interceding-token ngrams: the N-terminal extensiontinterceding-token ngrams: 9tVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sirt1'] themet-interceding-token ngrams: interaction of Set7tTe2: trigger-arg-path: binding prep_with [lemma='p53'] themetie2: trigger-arg-path: Binding prep_with [lemma='p53'] theme:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='p53'] Gene_or_gene_productt$interceding-token ngrams: , Lys236 ,t'interceding-token ngrams: Lys238 of thet>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 9 interactst%interceding-token ngrams: of Set7 andt]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sirt1'] Gene_or_gene_productt4interceding-token ngrams: directly SIRT1 deacetylasetie2: trigger-arg-path: binding prep_with [lemma='p53'] theme:Gene_or_gene_productt?interceding-tokens-full-span: , Lys236 , and Lys238 of the N-terminal extension . Although it is unclear whether methylation affects directly SIRT1 deacetylase activity , the interaction of Set7 and 9 with SIRT1 disrupts thet interceding-token ngrams: Lys238tfe2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='p53'] themet$interceding-token ngrams: is uncleart"interceding-token ngrams: Lys236 ,t%interceding-token ngrams: methylationtNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sirt1'] themet.interceding-token ngrams: extension . Althought'interceding-token ngrams: and Lys238 oft"interceding-token ngrams: Althoughtce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sirt1'] theme:Gene_or_gene_productt&interceding-token ngrams: 9 with SIRT1t$interceding-token ngrams: N-terminalt#interceding-token ngrams: extensiont,interceding-token ngrams: is unclear whethertinterceding-token ngrams: and 9t"interceding-token ngrams: , Lys236tqe2: trigger-arg-path: binding:Binding prep_with [lemma='p53'] theme:Gene_or_gene_productt0interceding-token ngrams: deacetylase activity ,t}e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='p53'] Gene_or_gene_producttke2: trigger-arg-path: binding:Binding prep_with [lemma='p53'] Gene_or_gene_producttce2: trigger-arg-path: Binding prep_with [lemma='p53'] Gene_or_gene_productt,interceding-token ngrams: the interaction oftKe2: trigger-arg-path: binding >prep_of [lemma='sirt1'] Gene_or_gene_productt(interceding-token ngrams: Although it ist5interceding-token ngrams: whether methylation affectstke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sirt1'] theme:Gene_or_gene_producttCSSPATH: ROOT  ++ ROOT >dobjt(interceding-token ngrams: activity , thetinterceding-token ngrams: Set7t%interceding-token ngrams: extension .tQe2: trigger-arg-path: binding >prep_of [lemma='sirt1'] theme:Gene_or_gene_productt5interceding-token ngrams: unclear whether methylationt*interceding-token ngrams: affects directlyt-interceding-token ngrams: whether methylationtDe2: trigger-arg-path: binding:Binding >prep_of [lemma='sirt1'] themet%interceding-token ngrams: Although itt0interceding-token ngrams: N-terminal extension .tKe2: trigger-arg-path: Binding >prep_of [lemma='sirt1'] Gene_or_gene_productt$interceding-token ngrams: and 9 witht'interceding-token ngrams: . Although itt interceding-token ngrams: 9 witht$interceding-token ngrams: Set7 and 9t(interceding-token ngrams: directly SIRT1t'interceding-token ngrams: it is uncleartprep_of [lemma='sirt1'] themet6interceding-token ngrams: methylation affects directlyt.interceding-token ngrams: N-terminal extensiont(interceding-token ngrams: the N-terminaltQe2: trigger-arg-path: Binding >prep_of [lemma='sirt1'] theme:Gene_or_gene_productt&interceding-token ngrams: Lys236 , andt$interceding-token ngrams: with SIRT1t4e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 9t?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_with [lemma='p53'] theme:Gene_or_gene_productt#interceding-token ngrams: Lys238 oft\e2: trigger-arg-path: binding:Binding prep_with [lemma='p53'] themet(interceding-token ngrams: interaction oft+interceding-token ngrams: , the interactiont&interceding-token ngrams: , and Lys238t interceding-token ngrams: Lys236t+interceding-token ngrams: SIRT1 deacetylaset$interceding-token ngrams: . Althought"interceding-token ngrams: Set7 andt(interceding-token ngrams: SIRT1 disruptst{e2: trigger-arg-path: lemmatizedTrigger=binding prep_with [lemma='p53'] theme:Gene_or_gene_productt-interceding-token ngrams: with SIRT1 disruptst4interceding-token ngrams: SIRT1 deacetylase activitytSe2: trigger-arg-path: binding:Binding >prep_of [lemma='sirt1'] Gene_or_gene_productt!interceding-token ngrams: of Set7tce2: trigger-arg-path: binding prep_with [lemma='p53'] Gene_or_gene_productt-interceding-token ngrams: methylation affectst&e1: ents2Label-mention-ngram: , Lys236t?interceding-tokens-full-span: of the N-terminal extension . Although it is unclear whether methylation affects directly SIRT1 deacetylase activity , the interaction of Set7 and 9 with SIRT1 disrupts thet&e1: ents2Label-mention-ngram: Lys235 ,t3e1: args2Role-mention-ngram: CONTROLLER 9 interactst-e1: ents2Label-mention-ngram: Lys235 , Lys236t(e1: ents2Label-mention-ngram: , Lys235 ,t$e1: ents2Label-mention-ngram: Lys236t%CSSPATH: ROOT >conj_and ++ ROOT >dobjt$e1: ents2Label-mention-ngram: Lys238t*e1: ents2Label-mention-ngram: Lys236 , andt&e1: ents2Label-mention-ngram: Lys236 ,t)e1: args2Role-mention-ngram: CONTROLLER 9t(e1: ents2Label-mention-ngram: , Lys236 ,t*e1: ents2Label-mention-ngram: , and Lys238t(e1: ents2Label-mention-ngram: and Lys238tprep_with [lemma='ttp'] themet.e2: args2Role-mention-ngram: interactions withtKe1: trigger-arg-path: Binding >prep_with [lemma='ttp'] Gene_or_gene_productt,interceding-token ngrams: region surroundingt-interceding-token ngrams: compartment as welltposs [lemma='its'] themet#interceding-token ngrams: . Throughtge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ttp'] theme:Gene_or_gene_productt,interceding-token ngrams: from the cytoplasmtoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_with [lemma='ttp'] Gene_or_gene_productt;e2: trigger-arg-path: interactions:Binding >prep_with themet4e2: args2Role-mention-ngram: THEME interactions witht$CSSPATH: ROOT  ++ ROOT >prep_throught+interceding-token ngrams: and redirects TTPtEe2: trigger-arg-path: interactions >poss [lemma='its'] Generic_entitytBe2: trigger-arg-path: interactions >prep_with Gene_or_gene_productt'interceding-token ngrams: the nucleus .t/e2: ents2Label-mention-ngram: interactions withtPe2: trigger-arg-path: interactions >prep_with [lemma='ttp'] Gene_or_gene_productt%interceding-token ngrams: surroundingtWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ttp'] themet6e2: ents2Label-mention-ngram: interactions with SHAREDt^e2: trigger-arg-path: interactions:Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_productt#interceding-token ngrams: cytoplasmtQe2: trigger-arg-path: Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ttp'] themetprep_with [lemma='ttp'] themet+interceding-token ngrams: nucleus . Throught%interceding-token ngrams: compartmentt3e2: trigger-arg-path: interactions >prep_with themetDe2: trigger-arg-path: interactions:Binding >poss [lemma='its'] themet1interceding-token ngrams: surrounding the nucleustinterceding-token ngrams: TTPt4e2: args2Role-mention-ngram: interactions with THEMEt?interceding-tokens-full-span: and redirects TTP from the cytoplasm to the nuclear compartment as well as in a region surrounding the nucleus . Throught1interceding-token ngrams: the nuclear compartmentt.interceding-token ngrams: a region surroundingtXe2: trigger-arg-path: interactions:Binding >prep_with [lemma='ttp'] Gene_or_gene_productt%interceding-token ngrams: in a regiont1e2: ents2Label-mention-ngram: SHARED interactionst^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ttp'] Gene_or_gene_productt interceding-token ngrams: regiontPe2: trigger-arg-path: interactions:Binding >prep_with theme:Gene_or_gene_producttMe1: trigger-arg-path: interacts >prep_with [lemma='ttp'] Gene_or_gene_producttSe2: trigger-arg-path: interactions:Binding >poss [lemma='its'] theme:Generic_entityt#interceding-token ngrams: redirectstie2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ttp'] Gene_or_gene_producttHe2: trigger-arg-path: interactions >prep_with theme:Gene_or_gene_productt"interceding-token ngrams: TTP fromt"interceding-token ngrams: a regiont0interceding-token ngrams: nuclear compartment ast,interceding-token ngrams: redirects TTP fromtRe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ttp'] themet!interceding-token ngrams: Throught6e2: ents2Label-mention-ngram: SHARED interactions withtfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ttp'] Gene_or_gene_producttIe2: trigger-arg-path: interactions:Binding >prep_with [lemma='ttp'] themetQe1: trigger-arg-path: Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_productt(interceding-token ngrams: to the nucleartae2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='ttp'] Gene_or_gene_producttKe2: trigger-arg-path: interactions >poss [lemma='its'] theme:Generic_entityt'interceding-token ngrams: the cytoplasmt-interceding-token ngrams: nuclear compartmentt*interceding-token ngrams: cytoplasm to thet[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='ttp'] themetJe2: trigger-arg-path: interactions:Binding >prep_with Gene_or_gene_productt#interceding-token ngrams: nucleus .t&interceding-token ngrams: cytoplasm tot'interceding-token ngrams: redirects TTPtAe2: trigger-arg-path: interactions >prep_with [lemma='ttp'] themet>e1: trigger-arg-path: interacts >prep_with [lemma='ttp'] themetMe2: trigger-arg-path: interactions:Binding >poss [lemma='its'] Generic_entityt!interceding-token ngrams: as in at)interceding-token ngrams: surrounding thet'interceding-token ngrams: and redirectstVe2: trigger-arg-path: interactions >prep_with [lemma='ttp'] theme:Gene_or_gene_producttUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ttp'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ttp'] theme:Gene_or_gene_productt&interceding-token ngrams: TTP from thet*interceding-token ngrams: the cytoplasm totFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ttp'] themet0interceding-token ngrams: region surrounding thetde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ttp'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interacts >prep_with [lemma='ttp'] theme:Gene_or_gene_productt(interceding-token ngrams: compartment astlinterceding-tokens-full-span: . Dmp1 ( cyclin D binding myb like protein 1 ; Dmtf1 ) , , - is unique in thatt?e2: trigger-arg-path: binds:Binding >nsubj theme:Generic_entityt-e1: ents2Label-mention-ngram: is repressed byt0e1: ents2Label-mention-ngram: nuclear proteins ,tXe1: trigger-arg-path: repressed:Negative_activation >agent >prep_of Gene_or_gene_productt interceding-token ngrams: , - ist;e2: ents2Label-mention-ngram: GENERIC_ENTITY directly bindst*e2: args2Role-mention-ngram: and activatest9e2: trigger-arg-path: binds:Binding >nsubj Generic_entitytinterceding-token ngrams: Dmtf1t+e1: args2Role-mention-ngram: and CONTROLLERtinterceding-token ngrams: , , -t|e1: trigger-arg-path: Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controller:Gene_or_gene_producttOe1: trigger-arg-path: repressed >agent >prep_of controller:Gene_or_gene_productt%CSSPATH: ROOT  ++ ROOT >dep >prepc_int|e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] Familyt#e1: args2Role-mention-ngram: numbertle2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familyt'e1: ents2Label-mention-ngram: repressedt^e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent >prep_of controllert^e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt(interceding-token ngrams: unique in thatt?e1: trigger-arg-path: Negative_activation >nsubjpass >nn Familyt interceding-token ngrams: cyclint'e1: args2Role-mention-ngram: Tbx2 and 3tCe1: trigger-arg-path: Negative_activation >nsubjpass >nn controlledt%e1: ents2Label-mention-ngram: 3 , andt#e1: args2Role-mention-ngram: , sucht)e1: args2Role-mention-ngram: Bmi1 , Twistt(e1: args2Role-mention-ngram: by a numbert+e1: ents2Label-mention-ngram: expression ist&e1: args2Role-mention-ngram: as Bmi1 ,tinterceding-token ngrams: - istfe1: trigger-arg-path: Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlledt0e2: args2Role-mention-ngram: binds and activatestNe1: trigger-arg-path: Negative_activation >agent >prep_of Gene_or_gene_producttinterceding-token ngrams: 1 ;t$e1: args2Role-mention-ngram: and 3 ,t!e1: args2Role-mention-ngram: sucht#e1: args2Role-mention-ngram: Bmi1 ,t%interceding-token ngrams: - is uniquetMe1: trigger-arg-path: repressed:Negative_activation >nsubjpass >nn controlledtJe1: trigger-arg-path: Negative_activation >nsubjpass >nn controlled:Familyt#interceding-token ngrams: ; Dmtf1 )t interceding-token ngrams: . Dmp1tNe2: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themetbe1: trigger-arg-path: Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] Familyt%e1: ents2Label-mention-ngram: such ast$e1: args2Role-mention-ngram: such ast]e1: trigger-arg-path: repressed >agent [lemma='number'] >prep_of [lemma='pokemon'] controllert:e1: trigger-arg-path: repressed >agent >prep_of controllert*e1: ents2Label-mention-ngram: such as Bmi1t9e1: trigger-arg-path: repressed >nsubjpass >nn controlledt2e1: ents2Label-mention-ngram: SHARED expression ist#interceding-token ngrams: is uniquetDe1: trigger-arg-path: Negative_activation >agent >prep_of controllertde2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familyt*e1: ents2Label-mention-ngram: is repressedtinterceding-token ngrams: mybt$interceding-token ngrams: ( cyclin Dt%e1: args2Role-mention-ngram: Tbx2 andt&e1: args2Role-mention-ngram: , Twist ,t"e1: ents2Label-mention-ngram: Tbx2t e1: args2Role-mention-ngram: 3 ,tPe1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass >nn controlled:Familyt1e1: ents2Label-mention-ngram: of nuclear proteinst!e1: args2Role-mention-ngram: by at#interceding-token ngrams: 1 ; Dmtf1t,e1: ents2Label-mention-ngram: repressed by at?e1: trigger-arg-path: lemmatizedTrigger=repress >agent [lemma='number'] >prep_of [lemma='pokemon'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: GENERIC_ENTITY directlyt'interceding-token ngrams: D binding mybtEe1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass >nn Familyt%interceding-token ngrams: binding mybt(e1: ents2Label-mention-ngram: of nucleartIe1: trigger-arg-path: repressed:Negative_activation >nsubjpass >nn Familyt%interceding-token ngrams: protein 1 ;t&e1: ents2Label-mention-ngram: Tbx2 andt*e1: ents2Label-mention-ngram: Bmi1 , Twistt*interceding-token ngrams: cyclin D bindingtme1: trigger-arg-path: lemmatizedTrigger=repress >agent [lemma='number'] >prep_of [lemma='pokemon'] controllert%e1: ents2Label-mention-ngram: and 3 ,t#interceding-token ngrams: unique int.e1: args2Role-mention-ngram: number of nucleart interceding-token ngrams: uniquet?e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controller:Gene_or_gene_producttle1: trigger-arg-path: repressed:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] Familyt*interceding-token ngrams: binding myb liketIe1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass >nn controlledtUe2: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familyt$e1: ents2Label-mention-ngram: , Tbx2t#interceding-token ngrams: protein 1t'interceding-token ngrams: Dmp1 ( cyclintee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themet7e2: trigger-arg-path: binds >nsubj theme:Generic_entityt\e1: trigger-arg-path: repressed >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlledt'e1: args2Role-mention-ngram: of nucleart?e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlled:Familyt?e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: as Bmi1 ,t5e2: trigger-arg-path: binds >nsubj [lemma='it'] themet)e1: ents2Label-mention-ngram: a number oft!interceding-token ngrams: Dmtf1 )t.e1: ents2Label-mention-ngram: nuclear proteinst$e1: args2Role-mention-ngram: , Twisttinterceding-token ngrams: , -te1: incoming: nsubjpass >nn controlled:FamilytDe1: trigger-arg-path: repressed >agent >prep_of Gene_or_gene_productt{e1: trigger-arg-path: repressed:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: Bmi1the1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass [lemma='expression'] >nn [lemma='arf'] Familyt%e1: ents2Label-mention-ngram: , Twistt#interceding-token ngrams: D bindingt1e2: trigger-arg-path: binds >nsubj Generic_entityt*e1: args2Role-mention-ngram: expression istwe1: trigger-arg-path: repressed:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlled:Familyt&interceding-token ngrams: is unique inte1: trigger: repressedtDe2: trigger-arg-path: binds >nsubj [lemma='it'] theme:Generic_entityt)e1: args2Role-mention-ngram: Twist , Tbx2tXe1: trigger-arg-path: repressed >nsubjpass [lemma='expression'] >nn [lemma='arf'] Familyt'e1: ents2Label-mention-ngram: , Twist ,t,e1: args2Role-mention-ngram: proteins , suchtge1: trigger-arg-path: Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controllertLe2: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] themet_e1: trigger-arg-path: lemmatizedTrigger=repress >agent >prep_of controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: repressed byt0e1: args2Role-mention-ngram: of nuclear proteinstYe1: trigger-arg-path: Negative_activation >agent >prep_of controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlledt&interceding-token ngrams: like proteintMe2: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] Familytce1: trigger-arg-path: repressed >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlled:Familyt.e2: args2Role-mention-ngram: and activates thet'e1: args2Role-mention-ngram: , Tbx2 andt#e1: args2Role-mention-ngram: , Tbx2t5e1: ents2Label-mention-ngram: expression is repressedtinterceding-token ngrams: ) , ,t&e1: args2Role-mention-ngram: , such ast"e1: ents2Label-mention-ngram: sucht(e1: args2Role-mention-ngram: a number oftce1: trigger-arg-path: repressed:Negative_activation >agent >prep_of controller:Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themetde1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass >nn controlled:Familyt=e2: trigger-arg-path: binds:Binding >nsubj [lemma='it'] themet5e1: trigger-arg-path: repressed >nsubjpass >nn Familyt+e1: args2Role-mention-ngram: repressed by at8e1: ents2Label-mention-ngram: , and GENE_OR_GENE_PRODUCTtre1: trigger-arg-path: repressed >agent [lemma='number'] >prep_of [lemma='pokemon'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: Tbx2t,e1: args2Role-mention-ngram: is repressed byt(e1: ents2Label-mention-ngram: , Tbx2 andtqe1: trigger-arg-path: Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=repress >agent >prep_of controllert!e1: ents2Label-mention-ngram: 3 ,t*interceding-token ngrams: myb like proteint#interceding-token ngrams: Dmtf1 ) ,t&e1: args2Role-mention-ngram: number oft&e1: args2Role-mention-ngram: repressedt-e1: args2Role-mention-ngram: nuclear proteinst>e2: trigger-arg-path: binds >nsubj [lemma='it'] Generic_entityt)e1: args2Role-mention-ngram: such as Bmi1tse1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlled:Familyt(interceding-token ngrams: like protein 1tqe1: trigger-arg-path: repressed:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controllert1e2: ents2Label-mention-ngram: binds and activatest"e1: args2Role-mention-ngram: and 3tUe2: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt"interceding-token ngrams: myb liket?e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controllert)e1: ents2Label-mention-ngram: by a numbert/e1: args2Role-mention-ngram: nuclear proteins ,tge1: trigger-arg-path: repressed >agent [lemma='number'] >prep_of [lemma='pokemon'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass >nn controlledt*e1: ents2Label-mention-ngram: Twist , Tbx2t$e1: ents2Label-mention-ngram: , sucht$e1: ents2Label-mention-ngram: numbertpe1: trigger-arg-path: repressed:Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlledt"e1: ents2Label-mention-ngram: by at interceding-token ngrams: Dmp1 (t"interceding-token ngrams: ( cyclint#e1: ents2Label-mention-ngram: and 3t/e1: ents2Label-mention-ngram: number of nucleartSe2: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familytle1: trigger-arg-path: lemmatizedTrigger=repress >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubjpass >nn Familytwe1: trigger-arg-path: lemmatizedTrigger=repress >agent [lemma='number'] >prep_of [lemma='pokemon'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent >prep_of controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: repressed byt'e1: ents2Label-mention-ngram: , such astNe1: trigger-arg-path: repressed:Negative_activation >agent >prep_of controllert'e1: ents2Label-mention-ngram: number oft"interceding-token ngrams: cyclin DtTe1: trigger-arg-path: lemmatizedTrigger=repress >agent >prep_of Gene_or_gene_productt$e1: ents2Label-mention-ngram: Bmi1 ,t%e1: ents2Label-mention-ngram: as Bmi1t!interceding-token ngrams: ; Dmtf1tfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt-e1: ents2Label-mention-ngram: proteins , suchtinterceding-token ngrams: , ,t$e1: args2Role-mention-ngram: 3 , andtLe2: trigger-arg-path: binds:Binding >nsubj [lemma='it'] theme:Generic_entitytme1: trigger-arg-path: Negative_activation >nsubjpass [lemma='expression'] >nn [lemma='arf'] controlled:Familyt%e1: args2Role-mention-ngram: a numbert-e1: args2Role-mention-ngram: , and CONTROLLERt$e1: args2Role-mention-ngram: as Bmi1t"interceding-token ngrams: . Dmp1 (t5e1: args2Role-mention-ngram: CONTROLLED expression ist0e2: args2Role-mention-ngram: activates the THEMEt!e1: args2Role-mention-ngram: Bmi1tFe2: trigger-arg-path: binds:Binding >nsubj [lemma='it'] Generic_entitytinterceding-token ngrams: Dmp1t@e1: trigger-arg-path: repressed >nsubjpass >nn controlled:Familyt%e1: ents2Label-mention-ngram: Twist ,t#e1: ents2Label-mention-ngram: Twistt*e2: args2Role-mention-ngram: activates thet]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] themet"e1: args2Role-mention-ngram: Twistt!interceding-token ngrams: in thatt4e1: args2Role-mention-ngram: expression is repressedt(e1: ents2Label-mention-ngram: Tbx2 and 3tOe2: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt[e2: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familythe1: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent >prep_of Gene_or_gene_productt?e1: trigger-arg-path: repressed:Negative_activation >agent [lemma='number'] >prep_of [lemma='pokemon'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: a numbert)e1: args2Role-mention-ngram: is repressedt$e1: args2Role-mention-ngram: Twist ,t,interceding-token ngrams: cooperates in thist-interceding-token ngrams: resulting in Snail1t(interceding-token ngrams: upregulation .tinterceding-token ngrams: 'st)e1: args2Role-mention-ngram: and IKKalphatoe2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] themet$interceding-token ngrams: complex ast9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to thet:e1: trigger-arg-path: Binding >nsubj [lemma='smad2'] themet,e1: args2Role-mention-ngram: concurrently totNe1: trigger-arg-path: Binding >prep_to [lemma='promoter'] Gene_or_gene_productt1e1: args2Role-mention-ngram: bind concurrently tot#interceding-token ngrams: Snail1 'stTe1: trigger-arg-path: bind:Binding >nsubj [lemma='smad2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='smad2'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: bind concurrentlyt)e1: args2Role-mention-ngram: concurrentlyt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] theme:Gene_or_gene_producttDe2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] themetNe1: trigger-arg-path: bind:Binding >nsubj [lemma='smad2'] Gene_or_gene_productt'interceding-token ngrams: cooperates int1e1: ents2Label-mention-ngram: concurrently to thetprep_of [lemma='hmga2'] themetre2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] themet+e1: ents2Label-mention-ngram: IKKalpha bindt?e1: trigger-arg-path: bind:Binding >nsubj [lemma='smad2'] themetQe2: trigger-arg-path: binding >prep_of [lemma='hmga2'] theme:Gene_or_gene_producttYe1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_producttme2: trigger-arg-path: binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] theme:Gene_or_gene_productt*interceding-token ngrams: between -631 andtme2: trigger-arg-path: Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: and IKKalpha bindt&interceding-token ngrams: in Snail1 'stinterceding-token ngrams: -506t"interceding-token ngrams: and -506t*e1: ents2Label-mention-ngram: and IKKalphatce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_of [lemma='hmga2'] Gene_or_gene_productt0e1: args2Role-mention-ngram: concurrently to thetke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] theme:Gene_or_gene_productt7e1: trigger-arg-path: bind >nsubj [lemma='smad2'] themet)interceding-token ngrams: in this complext?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and IKKalphat*e1: ents2Label-mention-ngram: concurrentlyt*interceding-token ngrams: HMGA2 cooperatestQe1: trigger-arg-path: bind >prep_to [lemma='promoter'] theme:Gene_or_gene_producttXe2: trigger-arg-path: binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='smad2'] themet-e1: ents2Label-mention-ngram: concurrently tot&interceding-token ngrams: between -631t0interceding-token ngrams: Snail1 's upregulationtLe1: trigger-arg-path: bind >nsubj [lemma='smad2'] theme:Gene_or_gene_producttKe1: trigger-arg-path: bind >prep_to [lemma='promoter'] Gene_or_gene_productt%e1: args2Role-mention-ngram: IKKalphat)e2: args2Role-mention-ngram: THEME to thetFe1: trigger-arg-path: bind >nsubj [lemma='smad2'] Gene_or_gene_productt#interceding-token ngrams: as well ,tKe2: trigger-arg-path: binding >prep_of [lemma='hmga2'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] Gene_or_gene_productt"interceding-token ngrams: -631 andtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='smad2'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: IKKalphatVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] themetQe2: trigger-arg-path: Binding >prep_of [lemma='hmga2'] theme:Gene_or_gene_productt!interceding-token ngrams: -506 bpt/e1: ents2Label-mention-ngram: bind concurrentlytQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='smad2'] themetTe1: trigger-arg-path: Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] themet!interceding-token ngrams: . HMGA2t%interceding-token ngrams: and -506 bptinterceding-token ngrams: bptge2: trigger-arg-path: Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='smad2'] theme:Gene_or_gene_productt$interceding-token ngrams: cooperatestNe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] themet'interceding-token ngrams: -631 and -506t"interceding-token ngrams: , as thet#interceding-token ngrams: in Snail1t interceding-token ngrams: Snail1tinterceding-token ngrams: -631t.interceding-token ngrams: upregulation . HMGA2t*e1: args2Role-mention-ngram: IKKalpha bindt7e1: args2Role-mention-ngram: IKKalpha bind concurrentlytprep_of [lemma='hmga2'] themetje2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] themetinterceding-token ngrams: bp ,t)interceding-token ngrams: 's upregulationtprep_to [lemma='promoter'] themetXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='smad2'] Gene_or_gene_productt,interceding-token ngrams: . HMGA2 cooperatest(interceding-token ngrams: bp , resultingtXe2: trigger-arg-path: Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] themetge2: trigger-arg-path: binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] Gene_or_gene_productt&interceding-token ngrams: upregulationt-interceding-token ngrams: HMGA2 cooperates int interceding-token ngrams: well ,tee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='smad2'] Gene_or_gene_productt#interceding-token ngrams: -506 bp ,tYe2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] Gene_or_gene_productt#interceding-token ngrams: well , ast8e1: ents2Label-mention-ngram: IKKalpha bind concurrentlytke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: THEME and IKKalphat)interceding-token ngrams: this complex astDe1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] themet?e1: trigger-arg-path: Binding >prep_to [lemma='promoter'] themet.e1: args2Role-mention-ngram: and IKKalpha bindt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] Gene_or_gene_producttSe2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] Gene_or_gene_producttue2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: bind concurrently totSe1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] Gene_or_gene_productt5CSSPATH: ROOT  ++ ROOT >prep_in >advmod >advcl >nsubjt`e2: trigger-arg-path: binding:Binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] themet)interceding-token ngrams: complex as welltIe1: trigger-arg-path: Binding >nsubj [lemma='smad2'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='hmga2'] >prep_to [lemma='promoter'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] theme:Gene_or_gene_productt?interceding-tokens-full-span: between -631 and -506 bp , resulting in Snail1 's upregulation . HMGA2 cooperates in this complex as well , as thet+interceding-token ngrams: 's upregulation .t1e2: args2Role-mention-ngram: ) protein CONTROLLEDt;e2: ents2Label-mention-ngram: protein phosphorylates SHAREDt2interceding-token ngrams: promotes p53 degradationt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt6e2: ents2Label-mention-ngram: ) protein phosphorylatest)e2: args2Role-mention-ngram: suppressor (tJe1: trigger-arg-path: interacts >nsubj [lemma='rybp'] Gene_or_gene_productt-interceding-token ngrams: while RNF2 promotestNe1: trigger-arg-path: Binding >nsubj [lemma='rybp'] theme:Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='rybp'] themet`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='hipk2'] Gene_or_gene_productt!e2: args2Role-mention-ngram: ( Tst3interceding-token ngrams: ubiquitination while RNF2tinterceding-token ngrams: RNF2t+interceding-token ngrams: RNF2 promotes p53t$e2: ents2Label-mention-ngram: ( Ts )t'interceding-token ngrams: RNF2 promotest e2: ents2Label-mention-ngram: Tst*e2: ents2Label-mention-ngram: Ts ) proteint:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , tumort'e2: ents2Label-mention-ngram: ) proteint!e2: args2Role-mention-ngram: Ts )tie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rybp'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='rybp'] Gene_or_gene_productte2: args2Role-mention-ngram: TstKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] controllert$interceding-token ngrams: while RNF2t4e2: ents2Label-mention-ngram: protein phosphorylatestce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rybp'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: ( TstRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rybp'] Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rybp'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: ( Ts )t[e2: trigger-arg-path: phosphorylates >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rybp'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: ) proteint%e2: ents2Label-mention-ngram: , tumort)e2: args2Role-mention-ngram: Ts ) proteint9e1: trigger-arg-path: Binding >nsubj [lemma='rybp'] themet/e2: args2Role-mention-ngram: protein CONTROLLEDtCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rybp'] themet&interceding-token ngrams: promotes p53t)interceding-token ngrams: p53 degradationt0e2: ents2Label-mention-ngram: tumor suppressor (tLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rybp'] themetde2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_producttZe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='hipk2'] controllert*e2: ents2Label-mention-ngram: suppressor (t-e2: ents2Label-mention-ngram: suppressor ( Tst/e2: args2Role-mention-ngram: tumor suppressor (tle2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='hipk2'] controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='hipk2'] controllertke2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='hipk2'] controllert/e2: args2Role-mention-ngram: CONTROLLER , tumortUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rybp'] themet0e2: ents2Label-mention-ngram: , tumor suppressort"e2: ents2Label-mention-ngram: Ts )toe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: suppressor ( Tst[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rybp'] Gene_or_gene_productt/e2: args2Role-mention-ngram: , tumor suppressortFe2: trigger-arg-path: phosphorylates >nsubj [lemma='hipk2'] controllertue2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='hipk2'] Gene_or_gene_productt$e2: args2Role-mention-ngram: , tumortPe1: trigger-arg-path: interacts >nsubj [lemma='rybp'] theme:Gene_or_gene_productt+interceding-token ngrams: p53 degradation .tpinterceding-tokens-full-span: to decrease MDM2 mediated p53 ubiquitination while RNF2 promotes p53 degradation .tPe2: trigger-arg-path: phosphorylates >nsubj [lemma='hipk2'] Gene_or_gene_productt%interceding-token ngrams: bound Cdc25t interceding-token ngrams: Ras tot>e1: trigger-arg-path: binding:Binding >prep_of >prep_to Familyt(interceding-token ngrams: complexed witht$interceding-token ngrams: expels thetBe1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] themet#interceding-token ngrams: the boundtke1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt%interceding-token ngrams: from wt RastOe1: trigger-arg-path: binding >prep_of [lemma='gtp'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_of [lemma='gtp'] themet6e1: trigger-arg-path: Binding >prep_of >prep_to FamilytDe1: trigger-arg-path: binding:Binding >prep_of >prep_to theme:Familyt&interceding-token ngrams: with Cdc25 ;t&interceding-token ngrams: this bindingtce1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themet6e1: args2Role-mention-ngram: cellularly abundant THEMEtLe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] themetTtrigger-to-trigger-path: e1:binding:Binding >parataxis >vmod >ccomp e2:bound:Bindingtprep_of >prep_to theme:Familyt-interceding-token ngrams: this binding expelst!interceding-token ngrams: from wtt+e1: args2Role-mention-ngram: abundant THEMEtPe1: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themet$interceding-token ngrams: with Cdc25t(e1: ents2Label-mention-ngram: cellularlyt interceding-token ngrams: expelst'e1: ents2Label-mention-ngram: to the wttIe1: trigger-arg-path: binding >prep_of [lemma='gtp'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] theme:Gene_or_gene_productt!interceding-token ngrams: producetWe1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt.e1: args2Role-mention-ngram: of the cellularlyt interceding-token ngrams: ; thistHe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to Familyt'e1: args2Role-mention-ngram: cellularlytWe1: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:FamilytIe1: trigger-arg-path: Binding >prep_of [lemma='gtp'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:FamilytQe1: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt?trigger-to-trigger-path: e1:binding:Binding >parataxis [lemma='expel'] >vmod [lemma='produce'] >ccomp [lemma='bind'] e2:bound:Bindingt0e1: ents2Label-mention-ngram: abundant SHARED tot-e1: ents2Label-mention-ngram: abundant SHAREDt)interceding-token ngrams: the bound Cdc25t6e1: trigger-arg-path: binding >prep_of >prep_to FamilytPe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to FamilytQe1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] Gene_or_gene_productt#interceding-token ngrams: wt Ras tot8e1: ents2Label-mention-ngram: cellularly abundant SHAREDt*interceding-token ngrams: expels the boundt+e1: ents2Label-mention-ngram: the wt SHAREDt(interceding-token ngrams: Ras to producetXe1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themetYe1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt+e1: args2Role-mention-ngram: the cellularlytointerceding-tokens-full-span: complexed with Cdc25 ; this binding expels the bound Cdc25 from wt Ras to producet$e1: ents2Label-mention-ngram: the wtt%e1: args2Role-mention-ngram: abundantt&interceding-token ngrams: Cdc25 ; thist(interceding-token ngrams: ; this bindingt5e1: ents2Label-mention-ngram: the cellularly abundantt[e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] Gene_or_gene_productt.e1: args2Role-mention-ngram: abundant THEME totbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themet1e1: ents2Label-mention-ngram: cellularly abundanttQe1: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt!interceding-token ngrams: Cdc25 ;t&e1: ents2Label-mention-ngram: abundanttWe1: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt*interceding-token ngrams: bound Cdc25 fromtPe1: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themetprep_of >prep_to theme:Familyt,interceding-token ngrams: binding expels thet.interceding-token ngrams: complexed with Cdc25t'interceding-token ngrams: Cdc25 from wtt$interceding-token ngrams: Cdc25 fromtVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to theme:FamilytOe1: trigger-arg-path: Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: the wt THEMEt#interceding-token ngrams: complexedt/e1: ents2Label-mention-ngram: of the cellularlyt0e1: args2Role-mention-ngram: cellularly abundantt$interceding-token ngrams: to producetTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] themetce1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt#e1: args2Role-mention-ngram: the wtt(interceding-token ngrams: binding expelst4e1: args2Role-mention-ngram: the cellularly abundanttNe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to theme:Familyt:e1: trigger-arg-path: binding >prep_of [lemma='gtp'] themet&e1: args2Role-mention-ngram: to the wtt_e1: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt,e1: ents2Label-mention-ngram: the cellularlytie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='socs7'] Gene_or_gene_productt/e1: args2Role-mention-ngram: THEME may directlytje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: may directlytJe1: trigger-arg-path: interact >nsubj [lemma='socs7'] Gene_or_gene_producttSe1: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: may directly interacttOe1: trigger-arg-path: Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_producttDe1: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] themetOe2: trigger-arg-path: Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: SHARED may directlytse1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: may directly interacttPe1: trigger-arg-path: interact >nsubj [lemma='socs7'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] themetMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] themetCe2: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] themet3e2: ents2Label-mention-ngram: may directly interactt)e1: args2Role-mention-ngram: may directlytme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_producttRe1: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] Gene_or_gene_productt;e2: trigger-arg-path: interact >nsubj [lemma='socs7'] themetMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] themetPe2: trigger-arg-path: interact >nsubj [lemma='socs7'] theme:Gene_or_gene_producttDe2: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] themet1e2: ents2Label-mention-ngram: SHARED may directlytRe1: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt/e2: args2Role-mention-ngram: THEME may directlyt:e1: trigger-arg-path: Binding >nsubj [lemma='socs7'] themetCe1: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] themetme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt;e1: trigger-arg-path: interact >nsubj [lemma='socs7'] themetde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] Gene_or_gene_producttYe1: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: may directlytSe2: trigger-arg-path: interact >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] themet[e1: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: may directlytee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: may directly interacttbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs7'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] Gene_or_gene_producttXe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_producttLe2: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] themetse2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttae1: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='socs7'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] themetJe2: trigger-arg-path: interact >nsubj [lemma='socs7'] Gene_or_gene_producttae2: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] themetLe1: trigger-arg-path: interact:Binding >prep_with [lemma='plcgamma-1'] themetee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] themetCe1: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] themet:e2: trigger-arg-path: Binding >nsubj [lemma='socs7'] themetke2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_producttXe1: trigger-arg-path: Binding >prep_with [lemma='plcgamma-1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='plcgamma-1'] themetRe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs7'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] themetje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs7'] theme:Gene_or_gene_productt'interceding-token ngrams: while ERK andt?e2: trigger-arg-path: Phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt+interceding-token ngrams: to UV-B radiationt)interceding-token ngrams: radiation couldtme2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by >nn controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: JNKt?e2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] Gene_or_gene_producttae1: trigger-arg-path: activation:Positive_activation >prep_by >nn controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: of JNK andt?e2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controllert?e2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controller:Gene_or_gene_producttoe2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by >nn controller:Gene_or_gene_productt"interceding-token ngrams: kinase Ctce1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='p38'] controlledtle1: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controllertKe1: trigger-arg-path: Positive_activation >prep_by >nn Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by >nn Gene_or_gene_productt#interceding-token ngrams: EGFR , ittCe1: trigger-arg-path: activation:Positive_activation >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >prep_of >prep_by >nn controller:Gene_or_gene_productt/interceding-token ngrams: to cell proliferationtLe1: trigger-arg-path: activation:Positive_activation >prep_by >nn controllert!interceding-token ngrams: againstt.e1: args2Role-mention-ngram: kinase activationt$interceding-token ngrams: by proteintAe1: trigger-arg-path: Positive_activation >prep_by >nn controllert.e2: args2Role-mention-ngram: CONTROLLED kinasetGe1: trigger-arg-path: activation >nn [lemma='p38'] Gene_or_gene_producttfe1: trigger-arg-path: activation:Positive_activation >nn [lemma='p38'] controlled:Gene_or_gene_productt1e2: args2Role-mention-ngram: kinase by CONTROLLERt%interceding-token ngrams: is mediatedt-interceding-token ngrams: against apoptosis ,t$interceding-token ngrams: kinase C (t+interceding-token ngrams: against apoptosistBe1: trigger-arg-path: activation >prep_by >nn Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='p38'] controlled:Gene_or_gene_producttxe1: trigger-arg-path: activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] Gene_or_gene_productt!interceding-token ngrams: to cellt%interceding-token ngrams: ERK and JNKt!interceding-token ngrams: C ( PKCt,interceding-token ngrams: protection againstt?e2: trigger-arg-path: Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controller:Gene_or_gene_producttne1: trigger-arg-path: activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controllertxe1: trigger-arg-path: Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt.interceding-token ngrams: regulated by proteintXe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by >nn controllert4e2: ents2Label-mention-ngram: Phosphorylation of JNKtinterceding-tokens-full-span: exposure is mediated by EGFR , it is associated with protection against apoptosis , while ERK and JNK activation in response to UV-B radiation could be regulated by protein kinase C ( PKC ) and is associated to cell proliferation .the1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn Gene_or_gene_productt5e1: args2Role-mention-ngram: activation by CONTROLLERtOe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='p38'] controlledt4interceding-token ngrams: associated with protectiontZe2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by >nn controllertve1: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] Gene_or_gene_productt=e1: trigger-arg-path: activation >nn [lemma='p38'] controlledt[e1: trigger-arg-path: Positive_activation >nn [lemma='p38'] controlled:Gene_or_gene_productt+interceding-token ngrams: by protein kinaset2e1: ents2Label-mention-ngram: kinase activation byt"interceding-token ngrams: exposuret+interceding-token ngrams: and is associatedt,interceding-token ngrams: and JNK activationtVe1: trigger-arg-path: activation:Positive_activation >prep_by >nn Gene_or_gene_productt%interceding-token ngrams: , while ERKt(interceding-token ngrams: UV-B radiationtinterceding-token ngrams: PKC )t%interceding-token ngrams: apoptosis ,t+interceding-token ngrams: JNK activation intinterceding-token ngrams: PKCt)interceding-token ngrams: be regulated byt&interceding-token ngrams: be regulatedtVe1: trigger-arg-path: lemmatizedTrigger=activation >nn controlled:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controlledt,e2: ents2Label-mention-ngram: JNK and SHAREDt*interceding-token ngrams: it is associatedtPe1: trigger-arg-path: Positive_activation >nn [lemma='p38'] Gene_or_gene_producttXe1: trigger-arg-path: activation:Positive_activation >nn controlled:Gene_or_gene_productt*interceding-token ngrams: mediated by EGFRt!interceding-token ngrams: to UV-BtJe1: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn controllert$interceding-token ngrams: protectiont6e1: ents2Label-mention-ngram: SHARED kinase activationt!interceding-token ngrams: by EGFRt.e1: args2Role-mention-ngram: CONTROLLED kinasetce1: trigger-arg-path: Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controllert!interceding-token ngrams: ERK andt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] Gene_or_gene_productt1interceding-token ngrams: with protection againstt%interceding-token ngrams: mediated byt1e1: args2Role-mention-ngram: kinase activation bytse1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn controller:Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >prep_of >prep_by >nn Gene_or_gene_producttQe1: trigger-arg-path: activation:Positive_activation >nn [lemma='p38'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn controllert(interceding-token ngrams: JNK activationt/e2: ents2Label-mention-ngram: and SHARED kinaset?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] Gene_or_gene_productt.interceding-token ngrams: exposure is mediatedt%interceding-token ngrams: exposure istZe1: trigger-arg-path: activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by >nn controller:Gene_or_gene_producttFe2: trigger-arg-path: Phosphorylation >prep_of >prep_by >nn controllertde2: trigger-arg-path: Phosphorylation:Positive_regulation >prep_of >prep_by >nn Gene_or_gene_productt[e2: trigger-arg-path: Phosphorylation >prep_of >prep_by >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: Phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] Gene_or_gene_producttinterceding-token ngrams: couldt,interceding-token ngrams: could be regulatedtYe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='p38'] Gene_or_gene_producttinterceding-token ngrams: C (t_e1: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn controller:Gene_or_gene_productt(interceding-token ngrams: is mediated bytAe1: trigger-arg-path: lemmatizedTrigger=activation >nn controlledt?e2: trigger-arg-path: Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controllert#interceding-token ngrams: while ERKt.e2: ents2Label-mention-ngram: SHARED kinase byte2: trigger: Phosphorylationt/e1: ents2Label-mention-ngram: kinase activationtde1: trigger-arg-path: activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt,interceding-token ngrams: associated to cellt,interceding-token ngrams: is associated witht%e2: ents2Label-mention-ngram: JNK andt)interceding-token ngrams: with protectiontme1: trigger-arg-path: Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: SHARED kinasetMe1: trigger-arg-path: activation >prep_by >nn controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='p38'] controlled:Gene_or_gene_productt8e1: trigger-arg-path: Positive_activation >nn controlledt#interceding-token ngrams: by EGFR ,t9e1: args2Role-mention-ngram: CONTROLLED kinase activationt!interceding-token ngrams: and JNKt|e2: trigger-arg-path: Phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controllertoe1: trigger-arg-path: activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: kinase bytDe1: trigger-arg-path: activation >nn controlled:Gene_or_gene_productt#interceding-token ngrams: radiationt*interceding-token ngrams: is associated tot?e1: trigger-arg-path: activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controller:Gene_or_gene_productt6interceding-token ngrams: protection against apoptosist?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controllertme1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='p38'] Gene_or_gene_productt*interceding-token ngrams: protein kinase Ct'interceding-token ngrams: associated totinterceding-token ngrams: ( PKCt.interceding-token ngrams: UV-B radiation couldt+interceding-token ngrams: apoptosis , whilet0interceding-token ngrams: activation in responsetMe1: trigger-arg-path: Positive_activation >nn controlled:Gene_or_gene_productt!interceding-token ngrams: ( PKC )t'interceding-token ngrams: is associatedt2e1: ents2Label-mention-ngram: activation by SHAREDt interceding-token ngrams: EGFR ,t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >prep_of >prep_by >nn controllert.e2: ents2Label-mention-ngram: kinase by SHAREDtinterceding-token ngrams: UV-BtPe2: trigger-arg-path: Phosphorylation >prep_of >prep_by >nn Gene_or_gene_producttRe1: trigger-arg-path: activation >nn [lemma='p38'] controlled:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of >prep_by >nn controllert1e2: args2Role-mention-ngram: CONTROLLED kinase byt.CSSPATH: ROOT >advcl >nsubjpass ++ ROOT >nsubjtVe1: trigger-arg-path: Positive_activation >prep_by >nn controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: of JNKt[e1: trigger-arg-path: activation:Positive_activation >nn [lemma='p38'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of >prep_by >nn Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] Gene_or_gene_productt&e2: args2Role-mention-ngram: kinase byt?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='exposure'] >nn [lemma='uv-b'] controllertTe1: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn Gene_or_gene_productt"interceding-token ngrams: ) and ist#interceding-token ngrams: PKC ) andt"interceding-token ngrams: could betFe1: trigger-arg-path: Positive_activation >nn [lemma='p38'] controlledtje1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controlled:Gene_or_gene_productt*interceding-token ngrams: response to UV-Bt8e1: trigger-arg-path: activation >prep_by >nn controllert/e1: trigger-arg-path: activation >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='kinase'] >prep_by [lemma='irradiation'] >nn [lemma='uv-b'] controllert,interceding-token ngrams: radiation could bet+e1: ents2Label-mention-ngram: SHARED kinasetNe2: trigger-arg-path: bound >prep_to [lemma='protein'] >nn [lemma='gst'] themet*e1: args2Role-mention-ngram: THEME nor GSTt2e1: ents2Label-mention-ngram: GST alone interactedt^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='panel'] >appos [lemma='ra'] Familyt|e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] Familyt&e1: args2Role-mention-ngram: GST alonet*interceding-token ngrams: or Ras-GTPgammaSt_e2: trigger-arg-path: Binding >prep_to [lemma='protein'] >nn [lemma='gst'] Gene_or_gene_productt_e1: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] >nn [lemma='gst'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt6e2: trigger-arg-path: bound:Binding >prep_to >nn themet!e1: ents2Label-mention-ngram: GSTtUe2: trigger-arg-path: Binding >nsubj [lemma='panel'] >appos [lemma='ra'] theme:Familyt@e1: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] themet8e2: trigger-arg-path: bound:Binding >nsubj >appos Familyt@e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >appos themet!interceding-token ngrams: panel ,tAe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >appos FamilytUe1: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_productt7e2: trigger-arg-path: bound:Binding >nsubj >appos themetbe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: nor GST alonetYe1: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT nortVe2: trigger-arg-path: bound:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] themet.e1: ents2Label-mention-ngram: alone interactedtPe2: trigger-arg-path: Binding >prep_to [lemma='protein'] >nn [lemma='gst'] themet1e1: args2Role-mention-ngram: GST alone interactedtKe1: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] themet.e2: trigger-arg-path: bound >prep_to >nn themet2e1: args2Role-mention-ngram: alone interacted withtLe2: trigger-arg-path: bound >nsubj [lemma='panel'] >appos [lemma='ra'] themetge1: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: FAMILY bound totbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themetee2: trigger-arg-path: bound:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: alone interacted witht'e1: ents2Label-mention-ngram: GST alonetinterceding-token ngrams: panelt%e1: ents2Label-mention-ngram: nor GSTtee2: trigger-arg-path: Binding >prep_to [lemma='protein'] >nn [lemma='gst'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: nor GSTtce2: trigger-arg-path: bound >prep_to [lemma='protein'] >nn [lemma='gst'] theme:Gene_or_gene_producttae1: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_producttCe1: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] themetHe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >appos themetZe1: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_producttUe2: trigger-arg-path: bound:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] Familyt1e2: trigger-arg-path: Binding >nsubj >appos themetOe1: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] themetZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] themet)interceding-token ngrams: Ras-GTPgammaS .t e1: args2Role-mention-ngram: GSTt-e1: args2Role-mention-ngram: alone interactedtRe1: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] Gene_or_gene_producttVe1: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] themet]e2: trigger-arg-path: bound >prep_to [lemma='protein'] >nn [lemma='gst'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='panel'] >appos [lemma='ra'] themet'interceding-token ngrams: Ras-GTPgammaSt%interceding-token ngrams: Top panel ,t#interceding-token ngrams: Top panelt/e2: trigger-arg-path: bound >nsubj >appos themetGe1: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themet2e2: trigger-arg-path: Binding >nsubj >appos Familytje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT nor GSTt%interceding-token ngrams: . Top panelt!e1: ents2Label-mention-ngram: nort*e1: args2Role-mention-ngram: nor GST alonet;e2: ents2Label-mention-ngram: bound to GENE_OR_GENE_PRODUCTtCe2: trigger-arg-path: bound >prep_to >nn theme:Gene_or_gene_producttEe2: trigger-arg-path: bound:Binding >prep_to >nn Gene_or_gene_productt>e2: trigger-arg-path: bound:Binding >nsubj >appos theme:FamilytRe1: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themet*e2: ents2Label-mention-ngram: FAMILY boundtinterceding-token ngrams: . Topt-interceding-token ngrams: Ras-GTPgammaS . Topt&e1: args2Role-mention-ngram: THEME nort\e1: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] themetNe2: trigger-arg-path: Binding >nsubj [lemma='panel'] >appos [lemma='ra'] themet,interceding-token ngrams: or Ras-GTPgammaS .tnsubj [lemma='panel'] >appos [lemma='ra'] theme:Familytinterceding-token ngrams: Toptpe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >appos FamilytXe1: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] theme:FamilytOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >appos theme:FamilytTe2: trigger-arg-path: bound:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] themette2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] >nn [lemma='gst'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj >appos theme:Familyt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] >nn [lemma='gst'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] themet6e2: trigger-arg-path: bound >nsubj >appos theme:Familytie1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] Gene_or_gene_productt"e1: args2Role-mention-ngram: alonetqe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_producttJe1: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] themet=e2: trigger-arg-path: bound >prep_to >nn Gene_or_gene_producttke2: trigger-arg-path: bound:Binding >prep_to [lemma='protein'] >nn [lemma='gst'] theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: alonetde2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='panel'] >appos [lemma='ra'] theme:Familythe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttKe2: trigger-arg-path: bound:Binding >prep_to >nn theme:Gene_or_gene_productt`e1: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj >appos theme:FamilytOe2: trigger-arg-path: Binding >nsubj [lemma='panel'] >appos [lemma='ra'] Familyt[e2: trigger-arg-path: bound:Binding >nsubj [lemma='panel'] >appos [lemma='ra'] theme:FamilytMe2: trigger-arg-path: bound >nsubj [lemma='panel'] >appos [lemma='ra'] Familyt e1: args2Role-mention-ngram: nort0e2: trigger-arg-path: bound >nsubj >appos FamilytXe2: trigger-arg-path: interaction >prep_between [lemma='dr3'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interaction >prep_between [lemma='dr3'] themet'e1: ents2Label-mention-ngram: , triggert%interceding-token ngrams: we obtainedtUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='dr3'] themetke1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='e-selectin'] controller:Gene_or_gene_productt&interceding-token ngrams: kinase ( SFKtde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='e-selectin'] themet!interceding-token ngrams: SFK ) -t"interceding-token ngrams: kinase (t:e1: ents2Label-mention-ngram: the tyrosine phosphorylationt?e2: trigger-arg-path: Binding >prep_between [lemma='dr3'] themet-e1: ents2Label-mention-ngram: SHARED and TL1AtDe1: trigger-arg-path: trigger >nsubj controller:Gene_or_gene_productt/e1: trigger-arg-path: trigger >nsubj controllert]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='dr3'] themet'interceding-token ngrams: Moreover , wet*e1: args2Role-mention-ngram: , the cognatet"interceding-token ngrams: obtainedt&e1: ents2Label-mention-ngram: and TL1At,interceding-token ngrams: dependent manner .t+e1: ents2Label-mention-ngram: ligand of DR3t+e1: args2Role-mention-ngram: cognate ligandtde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='dr3'] Gene_or_gene_productt$e1: args2Role-mention-ngram: triggertUe2: trigger-arg-path: Binding >prep_between [lemma='e-selectin'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='e-selectin'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >prep_between [lemma='e-selectin'] themet[e2: trigger-arg-path: Binding >prep_between [lemma='e-selectin'] theme:Gene_or_gene_producttZe1: trigger-arg-path: Positive_regulation >nsubj [lemma='e-selectin'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: trigger thetZe2: trigger-arg-path: interaction:Binding >prep_between [lemma='dr3'] Gene_or_gene_productt!e1: args2Role-mention-ngram: TL1Atke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='e-selectin'] Gene_or_gene_productt&interceding-token ngrams: a Src familyt+e1: ents2Label-mention-ngram: , trigger thetinterceding-token ngrams: SrctNe2: trigger-arg-path: Binding >prep_between [lemma='dr3'] Gene_or_gene_productt"interceding-token ngrams: manner .t`e2: trigger-arg-path: interaction:Binding >prep_between [lemma='dr3'] theme:Gene_or_gene_producttge2: trigger-arg-path: interaction:Binding >prep_between [lemma='e-selectin'] theme:Gene_or_gene_productt'interceding-token ngrams: family kinasetDe1: trigger-arg-path: trigger >nsubj [lemma='e-selectin'] controllert$e1: ents2Label-mention-ngram: of DR3t&e1: args2Role-mention-ngram: ligand oft'e1: args2Role-mention-ngram: TL1A , thet2interceding-token ngrams: evidence indicating thattbe1: trigger-arg-path: trigger:Positive_regulation >nsubj [lemma='e-selectin'] Gene_or_gene_productt'interceding-token ngrams: ) - dependenttje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='dr3'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: trigger thet"interceding-token ngrams: in a SrctNe1: trigger-arg-path: trigger >nsubj [lemma='e-selectin'] Gene_or_gene_productt'interceding-token ngrams: , we obtainedt*e1: args2Role-mention-ngram: ligand of DR3t"e1: args2Role-mention-ngram: DR3 ,t!e1: ents2Label-mention-ngram: DR3t%e1: ents2Label-mention-ngram: triggert/e1: args2Role-mention-ngram: the cognate ligandt#e1: ents2Label-mention-ngram: DR3 ,t.e1: args2Role-mention-ngram: cognate ligand oftKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='dr3'] themet(e1: ents2Label-mention-ngram: TL1A , thet+e1: ents2Label-mention-ngram: DR3 , triggertMe1: trigger-arg-path: trigger:Positive_regulation >nsubj Gene_or_gene_producttme1: trigger-arg-path: trigger:Positive_regulation >nsubj [lemma='e-selectin'] controller:Gene_or_gene_producttPe1: trigger-arg-path: Positive_regulation >nsubj [lemma='e-selectin'] controllertRe2: trigger-arg-path: interaction:Binding >prep_between [lemma='e-selectin'] themet!interceding-token ngrams: ( SFK )t$interceding-token ngrams: Src familyt?interceding-tokens-full-span: in a Src family kinase ( SFK ) - dependent manner . Moreover , we obtained evidence indicating thatt2e1: ents2Label-mention-ngram: trigger the tyrosinet9e1: trigger-arg-path: trigger >nsubj Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='e-selectin'] controllert+interceding-token ngrams: obtained evidencet)e1: args2Role-mention-ngram: the tyrosinet)e1: ents2Label-mention-ngram: the cognatetinterceding-token ngrams: SFKt,interceding-token ngrams: - dependent mannert$e1: args2Role-mention-ngram: cognatet$e1: ents2Label-mention-ngram: TL1A ,t1CSSPATH: ROOT >ccomp ++ ROOT >xcomp >ccomp >nsubjt#e1: args2Role-mention-ngram: of DR3t0e1: ents2Label-mention-ngram: the cognate ligandtre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='dr3'] theme:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='e-selectin'] theme:Gene_or_gene_producttinterceding-token ngrams: ) -t'e1: ents2Label-mention-ngram: ligand oft1e1: args2Role-mention-ngram: trigger the tyrosinet"e1: ents2Label-mention-ngram: TL1AtRe2: trigger-arg-path: interaction >prep_between [lemma='dr3'] Gene_or_gene_productt-interceding-token ngrams: evidence indicatingt&e1: args2Role-mention-ngram: , triggert*e1: args2Role-mention-ngram: , trigger thetse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='e-selectin'] Gene_or_gene_producttinterceding-token ngrams: a Srct,e1: ents2Label-mention-ngram: cognate ligandtTe2: trigger-arg-path: Binding >prep_between [lemma='dr3'] theme:Gene_or_gene_productt_e2: trigger-arg-path: interaction >prep_between [lemma='e-selectin'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: cognatet4e1: args2Role-mention-ngram: the tyrosine CONTROLLEDtCe1: trigger-arg-path: trigger:Positive_regulation >nsubj controllertee1: trigger-arg-path: Positive_regulation >nsubj [lemma='e-selectin'] controller:Gene_or_gene_producttYe1: trigger-arg-path: trigger >nsubj [lemma='e-selectin'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: , the cognatet%e1: args2Role-mention-ngram: of DR3 ,tle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='dr3'] Gene_or_gene_producttae2: trigger-arg-path: interaction:Binding >prep_between [lemma='e-selectin'] Gene_or_gene_productt(e1: args2Role-mention-ngram: the cognatet+interceding-token ngrams: manner . Moreovert6interceding-token ngrams: obtained evidence indicatingt%interceding-token ngrams: - dependenttinterceding-token ngrams: ( SFKte1: trigger: triggertXe1: trigger-arg-path: trigger:Positive_regulation >nsubj controller:Gene_or_gene_productt.interceding-token ngrams: we obtained evidencet*e1: args2Role-mention-ngram: DR3 , triggert\e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='e-selectin'] themet/e1: ents2Label-mention-ngram: cognate ligand oft#e1: args2Role-mention-ngram: TL1A ,tYe2: trigger-arg-path: interaction >prep_between [lemma='e-selectin'] Gene_or_gene_productt)interceding-token ngrams: family kinase (t&e1: ents2Label-mention-ngram: of DR3 ,t*e1: ents2Label-mention-ngram: the tyrosinetXe1: trigger-arg-path: trigger:Positive_regulation >nsubj [lemma='e-selectin'] controllertJe2: trigger-arg-path: interaction >prep_between [lemma='e-selectin'] themet'e1: args2Role-mention-ngram: and TL1A ,t`e1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='e-selectin'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='e-selectin'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: and TL1At0e1: args2Role-mention-ngram: CONTROLLER and TL1Atte1: trigger-arg-path: lemmatizedTrigger=trigger:Positive_regulation >nsubj [lemma='e-selectin'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: and TL1A ,t+interceding-token ngrams: Src family kinasetVe1: trigger-arg-path: lemmatizedTrigger=trigger >nsubj [lemma='e-selectin'] controllert e1: args2Role-mention-ngram: DR3tinterceding-token ngrams: SFK )t/e2: ents2Label-mention-ngram: also specificallyt7e1: args2Role-mention-ngram: CONTROLLER kinase directlyt)interceding-token ngrams: the presence oftje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertYe1: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] controllerthe2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt-interceding-token ngrams: - fused recombinanttte2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt+interceding-token ngrams: and detected witht interceding-token ngrams: , bothtinterceding-token ngrams: ( GSTtle2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertbe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt5interceding-token ngrams: glutathione S-transferase (tinterceding-token ngrams: GST )t)interceding-token ngrams: in the presencet&interceding-token ngrams: and detectedt(interceding-token ngrams: HA-ERK1 kinaset$interceding-token ngrams: . As shownt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt+interceding-token ngrams: HA-ERK1 kinase int1interceding-token ngrams: incubated with purifiedt)e2: args2Role-mention-ngram: kinase couldt)interceding-token ngrams: presence of ATPtse1: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt)interceding-token ngrams: FBW7 proteins ,t)interceding-token ngrams: S-transferase (t'interceding-token ngrams: mutant , werethe1: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt'interceding-token ngrams: wild type andt$interceding-token ngrams: the p-FBW7tnsubj >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: could also specificallytte1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt"interceding-token ngrams: purifiedt!interceding-token ngrams: GST ) -t,e1: args2Role-mention-ngram: kinase directlyt!interceding-token ngrams: ATP andt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert#interceding-token ngrams: kinase int"interceding-token ngrams: shown intinterceding-tokens-full-span: , glutathione S-transferase ( GST ) - fused recombinant FBW7 proteins , both wild type and T205A mutant , were incubated with purified HA-ERK1 kinase in the presence of ATP and detected with the p-FBW7 antibody . As shown in ,t%interceding-token ngrams: As shown int8e2: ents2Label-mention-ngram: specifically phosphorylatet3interceding-token ngrams: glutathione S-transferaset(interceding-token ngrams: both wild typet*e2: ents2Label-mention-ngram: specificallyt%e2: ents2Label-mention-ngram: at T205t)interceding-token ngrams: proteins , botht interceding-token ngrams: p-FBW7t%interceding-token ngrams: glutathionet"interceding-token ngrams: mutant ,tve2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt*interceding-token ngrams: recombinant FBW7tinterceding-token ngrams: . Ast'interceding-token ngrams: FBW7 proteinstce1: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt)interceding-token ngrams: p-FBW7 antibodyt'interceding-token ngrams: kinase in thet$interceding-token ngrams: shown in ,t)interceding-token ngrams: with the p-FBW7t'interceding-token ngrams: antibody . AstXe2: trigger-arg-path: phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert"interceding-token ngrams: As shownt/interceding-token ngrams: with purified HA-ERK1t.e2: args2Role-mention-ngram: kinase could alsot interceding-token ngrams: , weret(interceding-token ngrams: type and T205At(interceding-token ngrams: were incubatedtbe2: trigger-arg-path: phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED kinase directlytCe2: trigger-arg-path: phosphorylate >nsubj >nn Gene_or_gene_productt?e2: ents2Label-mention-ngram: specifically phosphorylate SHAREDtinterceding-token ngrams: fusedt!interceding-token ngrams: ( GST )tinterceding-token ngrams: Ast?e2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: kinase directlyt"interceding-token ngrams: antibodyt)e2: args2Role-mention-ngram: specificallyt(interceding-token ngrams: T205A mutant ,t*interceding-token ngrams: , were incubatedt"interceding-token ngrams: type andt!interceding-token ngrams: - fusedt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertWe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn Gene_or_gene_productt*interceding-token ngrams: and T205A mutantt1interceding-token ngrams: purified HA-ERK1 kinaset-interceding-token ngrams: were incubated witht%interceding-token ngrams: recombinantt5interceding-token ngrams: , glutathione S-transferasete2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt#interceding-token ngrams: incubatedt'interceding-token ngrams: detected witht(interceding-token ngrams: incubated witht$interceding-token ngrams: proteins ,tinterceding-token ngrams: FBW7t interceding-token ngrams: of ATPt!interceding-token ngrams: HA-ERK1t-interceding-token ngrams: the p-FBW7 antibodyt.e2: args2Role-mention-ngram: also specificallyt1e2: ents2Label-mention-ngram: SHARED kinase couldtse2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt$interceding-token ngrams: of ATP andt%interceding-token ngrams: , both wildtinterceding-token ngrams: ATPt/e2: ents2Label-mention-ngram: kinase could alsotwe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt'interceding-token ngrams: with purifiedt?e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttinterceding-token ngrams: in ,te1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt'interceding-token ngrams: , glutathionetinterceding-token ngrams: wildt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert4e2: args2Role-mention-ngram: specifically CONTROLLEDtMe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj >nn controllertje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert.e2: args2Role-mention-ngram: CONTROLLER kinaset+interceding-token ngrams: p-FBW7 antibody .t#interceding-token ngrams: ) - fusedt-interceding-token ngrams: S-transferase ( GSTt#interceding-token ngrams: wild typet$CSSPATH: ROOT >csubj >ccomp ++ ROOT t4e2: args2Role-mention-ngram: could also specificallyt'e2: args2Role-mention-ngram: could alsot"interceding-token ngrams: detectedt~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert4e2: args2Role-mention-ngram: CONTROLLER kinase couldtinterceding-token ngrams: GSTt+interceding-token ngrams: fused recombinantt*interceding-token ngrams: ATP and detectedt*e2: ents2Label-mention-ngram: kinase couldt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt*interceding-token ngrams: purified HA-ERK1t#interceding-token ngrams: both wildt$interceding-token ngrams: antibody .t3interceding-token ngrams: recombinant FBW7 proteinstme2: trigger-arg-path: phosphorylate >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED at T205t#interceding-token ngrams: and T205AtNe2: trigger-arg-path: phosphorylate >nsubj >nn controller:Gene_or_gene_productt=e2: ents2Label-mention-ngram: also specifically phosphorylatet9e2: args2Role-mention-ngram: also specifically CONTROLLEDt'interceding-token ngrams: S-transferaset0interceding-token ngrams: fused recombinant FBW7t+interceding-token ngrams: detected with thetme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertne1: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: could alsot&interceding-token ngrams: the presencetae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta'] Gene_or_gene_productt2interceding-token ngrams: bimolecular fluorescencet?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttse2: trigger-arg-path: Binding prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding prep_between Familytje2: trigger-arg-path: interaction:Binding prep_between [lemma='pi3kc2beta'] themet%interceding-token ngrams: bimoleculartprep_between Familyt+interceding-token ngrams: complementation (t]e2: trigger-arg-path: Binding prep_between [lemma='ra'] theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttBe2: trigger-arg-path: interaction prep_between theme:Familyt"interceding-token ngrams: in cellstPe2: trigger-arg-path: interaction prep_between theme:Gene_or_gene_productt6interceding-token ngrams: fluorescence complementationtme2: trigger-arg-path: Binding prep_between [lemma='pi3kc2beta'] Gene_or_gene_productt7e2: trigger-arg-path: Binding prep_between themetzinterceding-tokens-full-span: in cells using bimolecular fluorescence complementation ( BiFC ) , . We observed significanttJe2: trigger-arg-path: interaction prep_between Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='ra'] themet?e1: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta'] themetUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between themetbe2: trigger-arg-path: interaction prep_between [lemma='pi3kc2beta'] themet:e1: trigger-arg-path: interacted:Binding >prep_with Familyt interceding-token ngrams: BiFC )tRe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta'] themetZe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta'] themetBinterceding-token ngrams: bimolecular fluorescence complementationtVe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between Familytinterceding-token ngrams: Wetde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between Gene_or_gene_producttce2: trigger-arg-path: interaction:Binding prep_between [lemma='ra'] Familyt\e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between theme:Familyt1interceding-token ngrams: We observed significantt_e1: trigger-arg-path: interacted:Binding >nsubj [lemma='pi3kc2beta'] theme:Gene_or_gene_producttYe1: trigger-arg-path: interacted:Binding >nsubj [lemma='pi3kc2beta'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta'] theme:Gene_or_gene_producttVe2: trigger-arg-path: Binding prep_between [lemma='ra'] themetinterceding-token ngrams: , .t8interceding-token ngrams: using bimolecular fluorescencetFe1: trigger-arg-path: interacted:Binding >prep_with [lemma='ra'] themetWe2: trigger-arg-path: Binding prep_between [lemma='ra'] Familyt^e2: trigger-arg-path: Binding prep_between [lemma='pi3kc2beta'] themetXe2: trigger-arg-path: interaction:Binding prep_between theme:Gene_or_gene_productt>e1: trigger-arg-path: interacted >prep_with [lemma='ra'] themetZe2: trigger-arg-path: interaction prep_between [lemma='ra'] themetTe1: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta'] theme:Gene_or_gene_productt>e2: trigger-arg-path: Binding prep_between theme:Familyt)CSSPATH: ROOT >xcomp >ccomp ++ ROOT >dobjt{e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='ra'] theme:Familyt@e1: trigger-arg-path: interacted:Binding >prep_with theme:Familytbe2: trigger-arg-path: lemmatizedTrigger=interaction prep_between theme:Gene_or_gene_productt8interceding-token ngrams: fluorescence complementation (tme2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='ra'] FamilytNe2: trigger-arg-path: lemmatizedTrigger=interaction prep_between FamilytGe1: trigger-arg-path: interacted:Binding >prep_with [lemma='ra'] Familytue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='ra'] Familyt(interceding-token ngrams: in cells usingt8e1: trigger-arg-path: interacted >prep_with theme:FamilytFe2: trigger-arg-path: Binding prep_between Gene_or_gene_productt0interceding-token ngrams: complementation ( BiFCtJe2: trigger-arg-path: interaction:Binding prep_between theme:Familyte2: trigger-arg-path: interaction:Binding prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_productt)interceding-token ngrams: complementationt%interceding-token ngrams: significantt|e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='pi3kc2beta'] themetie2: trigger-arg-path: interaction:Binding prep_between [lemma='ra'] theme:Familytqe2: trigger-arg-path: interaction prep_between [lemma='pi3kc2beta'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttMe1: trigger-arg-path: interacted:Binding >prep_with [lemma='ra'] theme:FamilytQe1: trigger-arg-path: interacted >nsubj [lemma='pi3kc2beta'] Gene_or_gene_productt?e1: trigger-arg-path: interacted >prep_with [lemma='ra'] Familytinterceding-token ngrams: BiFCtwe2: trigger-arg-path: interaction prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pi3kc2beta'] theme:Gene_or_gene_productt%interceding-token ngrams: We observedt1interceding-token ngrams: cells using bimoleculart2e1: trigger-arg-path: interacted >prep_with Familytje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between theme:Gene_or_gene_productt.interceding-token ngrams: observed significanttRe2: trigger-arg-path: interaction:Binding prep_between Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=interaction prep_between themette2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='pi3kc2beta'] themetNe1: trigger-arg-path: Binding >nsubj [lemma='pi3kc2beta'] Gene_or_gene_productt[e2: trigger-arg-path: interaction prep_between [lemma='ra'] FamilytJe1: trigger-arg-path: interacted:Binding >nsubj [lemma='pi3kc2beta'] themet interceding-token ngrams: ( BiFCtse2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='ra'] theme:Familyt'interceding-token ngrams: . We observedt interceding-token ngrams: , . Wet;e2: trigger-arg-path: interaction prep_between themet"interceding-token ngrams: ( BiFC )tye2: trigger-arg-path: interaction:Binding prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttEe1: trigger-arg-path: interacted >prep_with [lemma='ra'] theme:FamilytTe2: trigger-arg-path: lemmatizedTrigger=interaction prep_between theme:FamilytDe2: trigger-arg-path: interaction:Binding prep_between Familyt"interceding-token ngrams: BiFC ) ,tbe2: trigger-arg-path: interaction:Binding prep_between [lemma='ra'] themet?e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttae2: trigger-arg-path: interaction prep_between [lemma='ra'] theme:FamilytBe1: trigger-arg-path: interacted >nsubj [lemma='pi3kc2beta'] themet\e2: trigger-arg-path: lemmatizedTrigger=interaction prep_between Gene_or_gene_producttinterceding-token ngrams: ) , .t%interceding-token ngrams: cells usingtWe1: trigger-arg-path: interacted >nsubj [lemma='pi3kc2beta'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction prep_between [lemma='ra'] themetinterceding-token ngrams: . Wetie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pi3kc2beta'] Gene_or_gene_productt+interceding-token ngrams: using bimoleculartCe2: trigger-arg-path: interaction:Binding prep_between themetLe2: trigger-arg-path: Binding prep_between theme:Gene_or_gene_productt!interceding-token ngrams: furthertVe1: trigger-arg-path: Binding >prep_between [lemma='gsk-3'] theme:Gene_or_gene_productt?interceding-tokens-full-span: has yet further repercussions , although Akt maintains its pro-developmental role in allowing glycogen synthesis .tRe1: trigger-arg-path: interaction >prep_between [lemma='akt'] Gene_or_gene_productt"interceding-token ngrams: allowingt+interceding-token ngrams: pro-developmentaltBe2: trigger-arg-path: phosphorylation >nn [lemma='akt'] controllertXe1: trigger-arg-path: interaction >prep_between [lemma='akt'] theme:Gene_or_gene_productt)interceding-token ngrams: has yet furthert.interceding-token ngrams: glycogen synthesis .t,interceding-token ngrams: glycogen synthesist?e1: trigger-arg-path: Binding >prep_between [lemma='akt'] themetNe1: trigger-arg-path: Binding >prep_between [lemma='akt'] Gene_or_gene_productt%interceding-token ngrams: yet furthertUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='akt'] themet&interceding-token ngrams: although Aktt/interceding-token ngrams: its pro-developmentaltfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gsk-3'] Gene_or_gene_productt!interceding-token ngrams: has yettVe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] controllert\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='gsk-3'] Gene_or_gene_productt'interceding-token ngrams: repercussionstZe1: trigger-arg-path: interaction >prep_between [lemma='gsk-3'] theme:Gene_or_gene_producttAe1: trigger-arg-path: Binding >prep_between [lemma='gsk-3'] themet+interceding-token ngrams: allowing glycogentPe2: trigger-arg-path: Positive_regulation >nn [lemma='akt'] Gene_or_gene_productt'interceding-token ngrams: Akt maintainstFe2: trigger-arg-path: Positive_regulation >nn [lemma='akt'] controllert#CSSPATH: ROOT >nsubj ++ ROOT >nsubjt0interceding-token ngrams: although Akt maintainstLe2: trigger-arg-path: phosphorylation >nn [lemma='akt'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gsk-3'] theme:Gene_or_gene_productt#interceding-token ngrams: synthesist#interceding-token ngrams: maintainstde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='akt'] Gene_or_gene_producttZe1: trigger-arg-path: interaction:Binding >prep_between [lemma='akt'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='akt'] controller:Gene_or_gene_productt)interceding-token ngrams: repercussions ,t`e2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gsk-3'] themet(interceding-token ngrams: , although Aktt"interceding-token ngrams: glycogentKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='akt'] themetWe2: trigger-arg-path: phosphorylation >nn [lemma='akt'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='akt'] Gene_or_gene_producttbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gsk-3'] theme:Gene_or_gene_productt/interceding-token ngrams: further repercussionst0interceding-token ngrams: pro-developmental roletje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='akt'] theme:Gene_or_gene_producttMe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gsk-3'] themet!interceding-token ngrams: role int*interceding-token ngrams: role in allowingtke2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='akt'] controller:Gene_or_gene_productt4interceding-token ngrams: its pro-developmental roletTe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='akt'] controllert.interceding-token ngrams: in allowing glycogent%interceding-token ngrams: synthesis .t`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='akt'] theme:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='akt'] Gene_or_gene_productt3interceding-token ngrams: pro-developmental role int+interceding-token ngrams: Akt maintains itst2interceding-token ngrams: repercussions , althought9interceding-token ngrams: maintains its pro-developmentalt5interceding-token ngrams: allowing glycogen synthesisthe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='akt'] controllertle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gsk-3'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interaction >prep_between [lemma='gsk-3'] Gene_or_gene_productt1interceding-token ngrams: further repercussions ,tCe1: trigger-arg-path: interaction >prep_between [lemma='akt'] themet%interceding-token ngrams: in allowingtre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='akt'] theme:Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_between [lemma='akt'] theme:Gene_or_gene_productt3interceding-token ngrams: yet further repercussionstie2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='akt'] controller:Gene_or_gene_producttEe1: trigger-arg-path: interaction >prep_between [lemma='gsk-3'] themet[e2: trigger-arg-path: Positive_regulation >nn [lemma='akt'] controller:Gene_or_gene_productt'interceding-token ngrams: maintains itstne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gsk-3'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gsk-3'] themetPe1: trigger-arg-path: Binding >prep_between [lemma='gsk-3'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='akt'] themetle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='akt'] Gene_or_gene_productt0interceding-token ngrams: phosphorylation of thet0interceding-token ngrams: adjacent Trk receptorst.interceding-token ngrams: and tyrosine residuet)interceding-token ngrams: Trk receptors .t:e1: trigger-arg-path: Binding >prep_of [lemma='ngf'] themet3interceding-token ngrams: receptor dimerisation andt;e2: trigger-arg-path: Binding >prep_to [lemma='trka'] themetPe2: trigger-arg-path: bound:Binding >prep_to [lemma='trka'] Gene_or_gene_productt*interceding-token ngrams: tyrosine residuetQe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='ngf'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_productt&interceding-token ngrams: dimerisationt+interceding-token ngrams: leads to receptort,interceding-token ngrams: of the cytoplasmictce1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] Gene_or_gene_productt%interceding-token ngrams: to receptortAe2: trigger-arg-path: bound:Binding >prep_to [lemma='trka'] themetOe2: trigger-arg-path: bound >nsubjpass [lemma='ngf'] theme:Gene_or_gene_productt4interceding-token ngrams: residue phosphorylation oftinterceding-token ngrams: Trkt#CSSPATH: ROOT >nsubj ++ ROOT >advcltIe2: trigger-arg-path: bound >nsubjpass [lemma='ngf'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_producttBe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='ngf'] themet3interceding-token ngrams: dimerisation and tyrosinetKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='ngf'] themetOe1: trigger-arg-path: Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt:e2: trigger-arg-path: bound >nsubjpass [lemma='ngf'] themetWe1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt9e2: trigger-arg-path: bound >prep_to [lemma='trka'] themet%interceding-token ngrams: by adjacentt1interceding-token ngrams: residue phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetinterceding-token ngrams: tailtoe1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='trka'] themethe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='ngf'] theme:Gene_or_gene_productt'interceding-token ngrams: Trk receptorst"interceding-token ngrams: adjacenttle1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='trka'] theme:Gene_or_gene_productt"interceding-token ngrams: tyrosinet?interceding-tokens-full-span: leads to receptor dimerisation and tyrosine residue phosphorylation of the cytoplasmic tail by adjacent Trk receptors . Whentnsubjpass [lemma='ngf'] themetQe2: trigger-arg-path: Binding >nsubjpass [lemma='ngf'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='trka'] theme:Gene_or_gene_productt#interceding-token ngrams: receptorstIe1: trigger-arg-path: Binding >prep_of [lemma='ngf'] Gene_or_gene_productt%interceding-token ngrams: cytoplasmict*interceding-token ngrams: receptors . Whent&interceding-token ngrams: and tyrosinet/interceding-token ngrams: receptor dimerisationtSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='ngf'] themetJe2: trigger-arg-path: Binding >prep_to [lemma='trka'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='ngf'] theme:Gene_or_gene_producttae1: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='trka'] themetBe1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] themetWe2: trigger-arg-path: bound:Binding >nsubjpass [lemma='ngf'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] themet:interceding-token ngrams: tyrosine residue phosphorylationt{e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubjpass [lemma='ngf'] Gene_or_gene_productt&interceding-token ngrams: adjacent Trktbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='ngf'] Gene_or_gene_producttie1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttHe2: trigger-arg-path: bound >prep_to [lemma='trka'] Gene_or_gene_productt.interceding-token ngrams: the cytoplasmic tailtae1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='trka'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='ngf'] Gene_or_gene_producttNe2: trigger-arg-path: bound >prep_to [lemma='trka'] theme:Gene_or_gene_productt)interceding-token ngrams: by adjacent TrktZe1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetVe2: trigger-arg-path: bound:Binding >prep_to [lemma='trka'] theme:Gene_or_gene_productt*interceding-token ngrams: dimerisation andtPe2: trigger-arg-path: Binding >prep_to [lemma='trka'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding:Binding >prep_of [lemma='ngf'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_productt*interceding-token ngrams: cytoplasmic tailt[e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] Gene_or_gene_productt*interceding-token ngrams: tail by adjacenttYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='trka'] Gene_or_gene_productt%interceding-token ngrams: receptors .t-interceding-token ngrams: cytoplasmic tail bytge1: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_productt)interceding-token ngrams: the cytoplasmict2interceding-token ngrams: to receptor dimerisationtLe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] themet!interceding-token ngrams: tail bytMe1: trigger-arg-path: complexes >nn [lemma='k-ra'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] themet8e1: trigger-arg-path: complexes >nn [lemma='k-ra'] themetGe2: trigger-arg-path: complexes >nn [lemma='raf1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: THEME complexest_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: and SHARED complexestGe2: trigger-arg-path: complexes >nn [lemma='k-ra'] Gene_or_gene_productt6e1: trigger-arg-path: Binding >nn [lemma='raf1'] themet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complexes >nn [lemma='k-ra'] theme:Gene_or_gene_producttUe1: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] Gene_or_gene_producttEe1: trigger-arg-path: Binding >nn [lemma='k-ra'] Gene_or_gene_producttUe2: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] theme:Gene_or_gene_productt)e1: trigger-arg-path: complexes >nn themetEe1: trigger-arg-path: Binding >nn [lemma='raf1'] Gene_or_gene_productt8e2: trigger-arg-path: complexes >nn [lemma='raf1'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] themet6e2: trigger-arg-path: Binding >nn [lemma='raf1'] themet6e1: trigger-arg-path: Binding >nn [lemma='k-ra'] themete1: trigger: complexestee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] theme:Gene_or_gene_productt@e2: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] themet8e2: trigger-arg-path: complexes >nn [lemma='k-ra'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] themetUe1: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] theme:Gene_or_gene_productt1e1: trigger-arg-path: complexes:Binding >nn themet@e1: trigger-arg-path: complexes:Binding >nn Gene_or_gene_producttUe2: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='raf1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] themetKe2: trigger-arg-path: Binding >nn [lemma='raf1'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] themet@e2: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] themet6e2: trigger-arg-path: Binding >nn [lemma='k-ra'] themetOe1: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] Gene_or_gene_producttFe1: trigger-arg-path: complexes:Binding >nn theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED complexest@e1: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] themet8e1: trigger-arg-path: complexes >nn Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] Gene_or_gene_producttGe1: trigger-arg-path: complexes >nn [lemma='raf1'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] themet8e1: trigger-arg-path: complexes >nn [lemma='raf1'] themet@e1: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='k-ra'] theme:Gene_or_gene_producttMe1: trigger-arg-path: complexes >nn [lemma='raf1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='k-ra'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raf1'] theme:Gene_or_gene_producttOe2: trigger-arg-path: complexes:Binding >nn [lemma='k-ra'] Gene_or_gene_producttGe1: trigger-arg-path: complexes >nn [lemma='k-ra'] Gene_or_gene_productt>e1: trigger-arg-path: complexes >nn theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complexes >nn [lemma='raf1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='raf1'] Gene_or_gene_producttOe2: trigger-arg-path: complexes:Binding >nn [lemma='raf1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raf1'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='k-ra'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='k-ra'] themet0e1: args2Role-mention-ngram: and THEME complexest]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='k-ra'] theme:Gene_or_gene_producttje2: trigger-arg-path: complex:Binding nn [lemma='p53'] theme:Gene_or_gene_productt#interceding-token ngrams: domains ,t.interceding-token ngrams: UHRF1 binds directlyt)interceding-token ngrams: interesting newtle2: trigger-arg-path: complex:Binding nn [lemma='tip60'] theme:Gene_or_gene_producttinterceding-tokens-full-span: whereas its depletion significantly increased K120 acetylation and p53 dependent apoptosis . UHRF1 binds directly to Tip60 through its SRA ( Set and RING associated ) and RING ( really interesting new gene ) domains , and in so doing markedly inhibitst"interceding-token ngrams: to Tip60t"interceding-token ngrams: so doingt+interceding-token ngrams: directly to Tip60tinterceding-token ngrams: doingt&interceding-token ngrams: associated )t#interceding-token ngrams: ) domainstfe2: trigger-arg-path: complex:Binding nn [lemma='tip60'] Gene_or_gene_producttbe2: trigger-arg-path: complex nn [lemma='p53'] theme:Gene_or_gene_productt"interceding-token ngrams: and RINGtinterceding-token ngrams: RINGt(interceding-token ngrams: binds directlytde2: trigger-arg-path: complex nn [lemma='tip60'] theme:Gene_or_gene_productt#interceding-token ngrams: SRA ( Sett)interceding-token ngrams: RING associatedt#interceding-token ngrams: ( Set andtbe2: trigger-arg-path: Binding nn [lemma='p53'] theme:Gene_or_gene_productt+interceding-token ngrams: RING associated )t(interceding-token ngrams: increased K120t)interceding-token ngrams: acetylation andt-interceding-token ngrams: acetylation and p53t+interceding-token ngrams: and p53 dependenttWe2: trigger-arg-path: complex:Binding nn [lemma='tip60'] themet!interceding-token ngrams: . UHRF1tde2: trigger-arg-path: complex:Binding nn [lemma='p53'] Gene_or_gene_productt.interceding-token ngrams: K120 acetylation andt#interceding-token ngrams: increasedtinterceding-token ngrams: in sot"interceding-token ngrams: new genet interceding-token ngrams: gene )t'interceding-token ngrams: significantlyt%interceding-token ngrams: ) domains ,tinterceding-token ngrams: genet0interceding-token ngrams: really interesting newt!interceding-token ngrams: its SRAt6interceding-token ngrams: significantly increased K120txe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] Gene_or_gene_productt/interceding-token ngrams: dependent apoptosis .t_e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] themetinterceding-token ngrams: newt%interceding-token ngrams: interestingt$interceding-token ngrams: ) and RINGt'interceding-token ngrams: domains , andt/interceding-token ngrams: whereas its depletiont1interceding-token ngrams: significantly increasedtinterceding-token ngrams: UHRF1tinterceding-token ngrams: SRAtinterceding-token ngrams: Sett-interceding-token ngrams: and RING associatedt+interceding-token ngrams: so doing markedlyt1interceding-token ngrams: p53 dependent apoptosist"interceding-token ngrams: ( reallyt+interceding-token ngrams: apoptosis . UHRF1tinterceding-token ngrams: SRA (t$interceding-token ngrams: and RING (tpe2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] Gene_or_gene_productt%interceding-token ngrams: through itstve2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] theme:Gene_or_gene_productt#interceding-token ngrams: and in sot)interceding-token ngrams: through its SRAtUe2: trigger-arg-path: complex:Binding nn [lemma='p53'] themet\e2: trigger-arg-path: Binding nn [lemma='p53'] Gene_or_gene_productt%interceding-token ngrams: directly tot!interceding-token ngrams: Set andt interceding-token ngrams: RING (t%interceding-token ngrams: whereas itst+interceding-token ngrams: Tip60 through itst^e2: trigger-arg-path: complex nn [lemma='tip60'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding nn [lemma='tip60'] themetie2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] themetOe2: trigger-arg-path: complex nn [lemma='tip60'] themetae2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] themet$interceding-token ngrams: new gene )t\e2: trigger-arg-path: complex nn [lemma='p53'] Gene_or_gene_productt*interceding-token ngrams: K120 acetylationt'interceding-token ngrams: its depletiont1interceding-token ngrams: doing markedly inhibitstinterceding-token ngrams: K120t&interceding-token ngrams: Set and RINGtinterceding-token ngrams: sot.interceding-token ngrams: ( really interestingt1interceding-token ngrams: depletion significantlyt(interceding-token ngrams: gene ) domainstinterceding-token ngrams: ( Sett'interceding-token ngrams: p53 dependentt'interceding-token ngrams: Tip60 throught'interceding-token ngrams: RING ( reallyt|e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] theme:Gene_or_gene_productt+interceding-token ngrams: markedly inhibitstve2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] Gene_or_gene_producttde2: trigger-arg-path: Binding nn [lemma='tip60'] theme:Gene_or_gene_productt(interceding-token ngrams: doing markedlytne2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] Gene_or_gene_productt!interceding-token ngrams: domainst;interceding-token ngrams: depletion significantly increasedt,interceding-token ngrams: really interestingt%interceding-token ngrams: UHRF1 bindst#interceding-token ngrams: its SRA (t*interceding-token ngrams: to Tip60 throught+interceding-token ngrams: binds directly totMe2: trigger-arg-path: Binding nn [lemma='p53'] themet4interceding-token ngrams: increased K120 acetylationt~e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] theme:Gene_or_gene_productt^e2: trigger-arg-path: Binding nn [lemma='tip60'] Gene_or_gene_productt*interceding-token ngrams: associated ) andt interceding-token ngrams: reallyt%interceding-token ngrams: in so doingt'interceding-token ngrams: . UHRF1 bindst7CSSPATH: ROOT  ++ ROOT >prepc_in >advmod >dep >dobj >nntMe2: trigger-arg-path: complex nn [lemma='p53'] themet5interceding-token ngrams: its depletion significantlyt!interceding-token ngrams: and p53t"interceding-token ngrams: markedlytge2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] themet.interceding-token ngrams: interesting new genet@e1: trigger-arg-path: acetylate >nsubj [lemma='p300'] controllert^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='importin-alpha'] themetfe1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj [lemma='p300'] controllertxcomp >prep_in >rcmod ++ ROOT >prepc_by >dobjt#interceding-token ngrams: import byt(interceding-token ngrams: action of p300t'interceding-token ngrams: also modulatet,interceding-token ngrams: import by blockingt"interceding-token ngrams: HDAC6 'st2e1: ents2Label-mention-ngram: can acetylate SHAREDt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interactiontRe1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj [lemma='p300'] controllert+interceding-token ngrams: can also modulatet"interceding-token ngrams: modulatet\e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='hdac6'] Gene_or_gene_producttUe1: trigger-arg-path: acetylate >nsubj [lemma='p300'] controller:Gene_or_gene_productt6e1: args2Role-mention-ngram: CONTROLLER can CONTROLLEDt%interceding-token ngrams: by blockingtOe1: trigger-arg-path: acetylate:Positive_regulation >nsubj Gene_or_gene_productt2e2: args2Role-mention-ngram: and THEME interactiontFe1: trigger-arg-path: acetylate >nsubj controller:Gene_or_gene_producttinterceding-token ngrams: HDAC6t interceding-token ngrams: importtie1: trigger-arg-path: acetylate:Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj controllert.interceding-token ngrams: HDAC6 nuclear importt"interceding-token ngrams: blockingt(interceding-token ngrams: nuclear importtee2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='importin-alpha'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_productt'interceding-token ngrams: HDAC6 nucleartme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='importin-alpha'] Gene_or_gene_productt"interceding-token ngrams: p300 cant0interceding-token ngrams: modulate HDAC6 nucleartJe2: trigger-arg-path: interaction >nn [lemma='hdac6'] Gene_or_gene_producttSe2: trigger-arg-path: interaction >nn [lemma='importin-alpha'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj controller:Gene_or_gene_producttPe2: trigger-arg-path: interaction >nn [lemma='hdac6'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj Gene_or_gene_producttYe2: trigger-arg-path: interaction >nn [lemma='importin-alpha'] theme:Gene_or_gene_productt(interceding-token ngrams: This action oftVe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='importin-alpha'] themetMe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='hdac6'] themet!interceding-token ngrams: of p300t_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='hdac6'] Gene_or_gene_producttTe1: trigger-arg-path: acetylate:Positive_regulation >nsubj [lemma='p300'] controllert'interceding-token ngrams: deacetylatingt-interceding-token ngrams: also modulate HDAC6t;e2: trigger-arg-path: interaction >nn [lemma='hdac6'] themetse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='importin-alpha'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: acetylate SHAREDt'e1: ents2Label-mention-ngram: acetylatet*interceding-token ngrams: 's deacetylatingtae2: trigger-arg-path: interaction:Binding >nn [lemma='importin-alpha'] theme:Gene_or_gene_productt0interceding-token ngrams: HDAC6 's deacetylatingt)interceding-token ngrams: activity . Thist,interceding-token ngrams: causing a decreaset+e1: ents2Label-mention-ngram: can acetylatet%interceding-token ngrams: of p300 cant\e1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj [lemma='p300'] Gene_or_gene_producttZe1: trigger-arg-path: acetylate:Positive_regulation >nsubj controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_productt?interceding-tokens-full-span: , causing a decrease in HDAC6 's deacetylating activity . This action of p300 can also modulate HDAC6 nuclear import by blocking thet@e2: trigger-arg-path: Binding >nn [lemma='importin-alpha'] themetLe2: trigger-arg-path: interaction:Binding >nn [lemma='importin-alpha'] themetCe2: trigger-arg-path: interaction:Binding >nn [lemma='hdac6'] themet&interceding-token ngrams: blocking thetXe2: trigger-arg-path: interaction:Binding >nn [lemma='hdac6'] theme:Gene_or_gene_producttBe2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT interactiont[e2: trigger-arg-path: interaction:Binding >nn [lemma='importin-alpha'] Gene_or_gene_productt+interceding-token ngrams: nuclear import byt+interceding-token ngrams: decrease in HDAC6t3interceding-token ngrams: 's deacetylating activitytge1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj [lemma='p300'] controller:Gene_or_gene_productt%interceding-token ngrams: This actiont%interceding-token ngrams: , causing at^e1: trigger-arg-path: acetylate:Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_productt$interceding-token ngrams: a decreaset)interceding-token ngrams: by blocking thetEe1: trigger-arg-path: acetylate:Positive_regulation >nsubj controllert"interceding-token ngrams: in HDAC6tMe1: trigger-arg-path: lemmatizedTrigger=acetylate >nsubj Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='hdac6'] themetWe1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj controllertOe2: trigger-arg-path: Binding >nn [lemma='importin-alpha'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='hdac6'] theme:Gene_or_gene_productt2interceding-token ngrams: deacetylating activity .tke2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='importin-alpha'] theme:Gene_or_gene_productt'interceding-token ngrams: . This actiontJe1: trigger-arg-path: acetylate >nsubj [lemma='p300'] Gene_or_gene_productt1e1: trigger-arg-path: acetylate >nsubj controllertpe1: trigger-arg-path: lemmatizedTrigger=acetylate:Positive_regulation >nsubj [lemma='p300'] Gene_or_gene_producttRe2: trigger-arg-path: interaction:Binding >nn [lemma='hdac6'] Gene_or_gene_productt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can acetylatet#interceding-token ngrams: causing at;e1: trigger-arg-path: acetylate >nsubj Gene_or_gene_productt'interceding-token ngrams: a decrease inte1: trigger: acetylatetUe2: trigger-arg-path: Binding >nn [lemma='importin-alpha'] theme:Gene_or_gene_productt0interceding-token ngrams: deacetylating activityt'interceding-token ngrams: p300 can alsot%interceding-token ngrams: in HDAC6 'st(interceding-token ngrams: modulate HDAC6tJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p300'] controllertDe2: trigger-arg-path: interaction >nn [lemma='importin-alpha'] themetje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='hdac6'] theme:Gene_or_gene_productt"interceding-token ngrams: can alsot$interceding-token ngrams: box domaint)interceding-token ngrams: HMGB1 interactstRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tlr4'] themetJe1: trigger-arg-path: Binding >prep_to [lemma='tlr4'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='md2'] themet.interceding-token ngrams: a structure specifictHe1: trigger-arg-path: binds >prep_to [lemma='tlr4'] Gene_or_gene_productt&interceding-token ngrams: B box domaintVe1: trigger-arg-path: binds:Binding >prep_to [lemma='tlr4'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='md2'] themet"interceding-token ngrams: of HMGB1tee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tlr4'] theme:Gene_or_gene_productt0interceding-token ngrams: interacts specificallyt(interceding-token ngrams: in a structuret.CSSPATH: ROOT >ccomp >advcl ++ ROOT >prep_witht&interceding-token ngrams: specificallyt#interceding-token ngrams: structuretYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tlr4'] Gene_or_gene_productt,interceding-token ngrams: of HMGB1 interactst+interceding-token ngrams: specifically withtSe2: trigger-arg-path: complex:Binding >nn [lemma='tlr4'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tlr4'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='tlr4'] themet?interceding-tokens-full-span: in a structure specific manner . The recombinant B box domain of HMGB1 interacts specifically with thetKe2: trigger-arg-path: complex >nn [lemma='tlr4'] theme:Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >prep_to [lemma='tlr4'] themetinterceding-token ngrams: boxt+interceding-token ngrams: specific manner .tKe2: trigger-arg-path: Binding >nn [lemma='tlr4'] theme:Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='md2'] Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='tlr4'] Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='md2'] themet5e1: ents2Label-mention-ngram: GENERIC_ENTITY binds totNe1: trigger-arg-path: binds >prep_to [lemma='tlr4'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='md2'] themet5e2: trigger-arg-path: complex >nn [lemma='md2'] themet\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='md2'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='md2'] theme:Gene_or_gene_productt'interceding-token ngrams: box domain oft+interceding-token ngrams: The recombinant Bt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tlr4'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='tlr4'] Gene_or_gene_producttinterceding-token ngrams: HMGB1tEe2: trigger-arg-path: complex >nn [lemma='tlr4'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='md2'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tlr4'] themetPe1: trigger-arg-path: Binding >prep_to [lemma='tlr4'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='md2'] theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='md2'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='tlr4'] themet%interceding-token ngrams: a structuret+interceding-token ngrams: recombinant B boxt,interceding-token ngrams: structure specifictinterceding-token ngrams: B boxt2e1: ents2Label-mention-ngram: GENERIC_ENTITY bindst9e1: trigger-arg-path: binds >prep_to [lemma='tlr4'] themet3interceding-token ngrams: structure specific mannert+interceding-token ngrams: . The recombinanttLe2: trigger-arg-path: complex:Binding >nn [lemma='md2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tlr4'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tlr4'] Gene_or_gene_productt&interceding-token ngrams: manner . Thet>e2: trigger-arg-path: complex:Binding >nn [lemma='tlr4'] themet6interceding-token ngrams: HMGB1 interacts specificallyt)interceding-token ngrams: The recombinanttRe2: trigger-arg-path: complex:Binding >nn [lemma='md2'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='md2'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tlr4'] theme:Gene_or_gene_productt'interceding-token ngrams: recombinant BtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='tlr4'] themetEe2: trigger-arg-path: Binding >nn [lemma='tlr4'] Gene_or_gene_productt5interceding-token ngrams: interacts specifically witht)interceding-token ngrams: domain of HMGB1t/interceding-token ngrams: specifically with thet6e2: trigger-arg-path: complex >nn [lemma='tlr4'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='md2'] Gene_or_gene_productt)interceding-token ngrams: specific mannertPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tlr4'] themetae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='tlr4'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHARED has alsotee1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='polyubiquitin'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: and can bindt$e1: args2Role-mention-ngram: and cant%e1: args2Role-mention-ngram: has alsotde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hdac6'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hsp90'] Familyt(e1: args2Role-mention-ngram: enzymes andt:e2: trigger-arg-path: Binding >nsubj [lemma='hdac6'] themetFe1: trigger-arg-path: bind >nsubj [lemma='hdac6'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: deubiquitinatingt%e1: ents2Label-mention-ngram: enzymestIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hdac6'] themet;e1: ents2Label-mention-ngram: can bind GENE_OR_GENE_PRODUCTtIe2: trigger-arg-path: Binding >nsubj [lemma='hdac6'] Gene_or_gene_productt$e1: args2Role-mention-ngram: enzymest\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hdac6'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: has alsot_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='polyubiquitin'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hdac6'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hdac6'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME has alsotUe1: trigger-arg-path: bind:Binding >dobj [lemma='polyubiquitin'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: has also beent2e1: ents2Label-mention-ngram: been copurified witht,e1: args2Role-mention-ngram: copurified withtSe1: trigger-arg-path: bind >dobj [lemma='polyubiquitin'] theme:Gene_or_gene_producttnsubj [lemma='hdac6'] themet:e1: ents2Label-mention-ngram: deubiquitinating enzymes andt%e1: ents2Label-mention-ngram: and cantPe1: trigger-arg-path: Binding >dobj [lemma='polyubiquitin'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED also interactstXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hdac6'] Gene_or_gene_producttVe1: trigger-arg-path: Binding >dobj [lemma='polyubiquitin'] theme:Gene_or_gene_producttMe1: trigger-arg-path: bind >dobj [lemma='polyubiquitin'] Gene_or_gene_producttIe2: trigger-arg-path: interacts:Binding >prep_with [lemma='hsp90'] Familyt1e1: args2Role-mention-ngram: also been copurifiedt,e1: args2Role-mention-ngram: enzymes and cant^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttQe2: trigger-arg-path: interacts >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hdac6'] themet-e1: args2Role-mention-ngram: deubiquitinatingtme1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='polyubiquitin'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hsp90'] themet;e1: ents2Label-mention-ngram: with deubiquitinating enzymest3e1: ents2Label-mention-ngram: with deubiquitinatingtbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hdac6'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: been copurified witht`e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hsp90'] theme:Familyt&e1: args2Role-mention-ngram: THEME hast@e2: trigger-arg-path: interacts >prep_with [lemma='hsp90'] themet?e2: trigger-arg-path: Binding >prep_with [lemma='hsp90'] Familyt2e1: args2Role-mention-ngram: with deubiquitinatingt-e1: ents2Label-mention-ngram: copurified withtQe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hsp90'] themet[e1: trigger-arg-path: bind:Binding >dobj [lemma='polyubiquitin'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: been copurifiedtje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hdac6'] themetIe1: trigger-arg-path: Binding >nsubj [lemma='hdac6'] Gene_or_gene_producttHe2: trigger-arg-path: interacts:Binding >prep_with [lemma='hsp90'] themetOe2: trigger-arg-path: interacts:Binding >prep_with [lemma='hsp90'] theme:Familyt>e1: ents2Label-mention-ngram: copurified with deubiquitinatingtDe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hdac6'] themetYe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='polyubiquitin'] themetOe1: trigger-arg-path: Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: enzymes and cant=e1: args2Role-mention-ngram: copurified with deubiquitinatingtFe1: trigger-arg-path: bind:Binding >dobj [lemma='polyubiquitin'] themet*e1: args2Role-mention-ngram: has also beent:e1: args2Role-mention-ngram: with deubiquitinating enzymestSe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hdac6'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: deubiquitinating enzymest>e2: trigger-arg-path: Binding >prep_with [lemma='hsp90'] themet)e1: ents2Label-mention-ngram: enzymes andt)e1: args2Role-mention-ngram: and can bindt:e1: trigger-arg-path: Binding >nsubj [lemma='hdac6'] themetNe1: trigger-arg-path: bind:Binding >nsubj [lemma='hdac6'] Gene_or_gene_producttTe1: trigger-arg-path: bind:Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttAe2: trigger-arg-path: interacts >prep_with [lemma='hsp90'] FamilytOe2: trigger-arg-path: Binding >nsubj [lemma='hdac6'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: deubiquitinating enzymest'e1: args2Role-mention-ngram: copurifiedt9e1: args2Role-mention-ngram: deubiquitinating enzymes andt-e1: ents2Label-mention-ngram: been copurifiedtKe2: trigger-arg-path: interacts >nsubj [lemma='hdac6'] Gene_or_gene_productt>e1: trigger-arg-path: bind >dobj [lemma='polyubiquitin'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='polyubiquitin'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: also been copurifiedtXe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='polyubiquitin'] themetEe2: trigger-arg-path: Binding >prep_with [lemma='hsp90'] theme:Familyt(e1: ents2Label-mention-ngram: copurifiedt7e1: trigger-arg-path: bind >nsubj [lemma='hdac6'] themetLe1: trigger-arg-path: bind >nsubj [lemma='hdac6'] theme:Gene_or_gene_producttGe2: trigger-arg-path: interacts >prep_with [lemma='hsp90'] theme:FamilytXe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hsp90'] theme:Familyt CSSPATH: ROOT >conj_and ++ ROOT tRe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hsp90'] FamilytAe1: trigger-arg-path: Binding >dobj [lemma='polyubiquitin'] themet?e1: trigger-arg-path: bind:Binding >nsubj [lemma='hdac6'] themet%interceding-token ngrams: activity int~e1: trigger-arg-path: Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_producttoe1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt%e2: args2Role-mention-ngram: can bindtfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED increasestNe2: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] Gene_or_gene_productt_e1: trigger-arg-path: increases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllertinterceding-token ngrams: UsingtUe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn Familytte1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt`e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlled:Familyt=e2: trigger-arg-path: bind >prep_to [lemma='ra'] theme:Familyt'interceding-token ngrams: based screenstPe1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='ra'] Familyt+e2: args2Role-mention-ngram: THEME can bindt(e2: args2Role-mention-ngram: can bind tot%interceding-token ngrams: array basedtze1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_producttDe1: trigger-arg-path: increases:Positive_activation >dobj >nn Familyt^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt+interceding-token ngrams: based screens andtIe2: trigger-arg-path: Binding >nsubj [lemma='gal-3'] Gene_or_gene_productt'interceding-token ngrams: we found thatt*interceding-token ngrams: . Using antibodyt"interceding-token ngrams: assays ,tae1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] Familytse1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert_e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of controllertXe1: trigger-arg-path: increases:Positive_activation >nsubj >prep_of Gene_or_gene_producttse1: trigger-arg-path: Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_productt.interceding-token ngrams: antibody array basedt7e2: trigger-arg-path: bind >prep_to [lemma='ra'] Familytee1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] controlledt*e2: args2Role-mention-ngram: bind to THEMEtAe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn Familyt interceding-token ngrams: assaystde1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt;e1: trigger-arg-path: increases >dobj >nn controlled:FamilytTe1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='ra'] controlledt?interceding-tokens-full-span: activity in pancreatic cancer cells . Using antibody array based screens and immunoprecipitation assays , we found thattye1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt^e1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt$interceding-token ngrams: , we foundtXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] Gene_or_gene_productt%interceding-token ngrams: screens andtinterceding-token ngrams: arrayt.e1: ents2Label-mention-ngram: increases SHAREDt-interceding-token ngrams: immunoprecipitationtie1: trigger-arg-path: increases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gal-3'] themetZe1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familytie1: trigger-arg-path: Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert:e1: trigger-arg-path: Positive_activation >dobj >nn Familytpe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllertEe1: trigger-arg-path: Positive_activation >dobj >nn controlled:FamilytEe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlledt6e2: trigger-arg-path: bind >prep_to [lemma='ra'] themet1CSSPATH: ROOT >ccomp >advcl >advcl ++ ROOT >ccompt"interceding-token ngrams: we foundtinterceding-token ngrams: basedt%interceding-token ngrams: assays , wetNe1: trigger-arg-path: increases:Positive_activation >nsubj >prep_of controllertEe2: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] theme:Familyt?e2: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] Familytle1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] controlled:FamilytQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] themet7e2: trigger-arg-path: bind >nsubj [lemma='gal-3'] themet>e2: trigger-arg-path: bind:Binding >prep_to [lemma='ra'] themet(interceding-token ngrams: cancer cells .the1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledtFe2: trigger-arg-path: bind >nsubj [lemma='gal-3'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlledtte1: trigger-arg-path: increases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productt-interceding-token ngrams: array based screenstLe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlled:Familyt.interceding-token ngrams: Using antibody arrayt?e1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productt!interceding-token ngrams: cells .t4e1: trigger-arg-path: increases >dobj >nn controlledtHe1: trigger-arg-path: increases:Positive_activation >dobj >nn controlledtce1: trigger-arg-path: increases:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt(interceding-token ngrams: antibody arrayt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: SHARED increases SHAREDt4interceding-token ngrams: immunoprecipitation assayst1interceding-token ngrams: and immunoprecipitationt[e1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='ra'] controlled:FamilytOe1: trigger-arg-path: increases:Positive_activation >dobj >nn controlled:Familyt8interceding-token ngrams: and immunoprecipitation assayst0interceding-token ngrams: activity in pancreatict!interceding-token ngrams: screenst`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gal-3'] Gene_or_gene_productt0e1: trigger-arg-path: increases >dobj >nn Familyt'interceding-token ngrams: cells . UsingtLe2: trigger-arg-path: bind >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt(interceding-token ngrams: Using antibodytTe2: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: increases CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: bind to SHAREDtee1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:FamilytOe2: trigger-arg-path: Binding >nsubj [lemma='gal-3'] theme:Gene_or_gene_producttnsubj [lemma='gal-3'] themet$interceding-token ngrams: found thatt9interceding-token ngrams: screens and immunoprecipitationt!interceding-token ngrams: . Usingt6interceding-token ngrams: immunoprecipitation assays ,t?e2: trigger-arg-path: bind:Binding >nsubj [lemma='gal-3'] themet}e1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: can bind tot?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familytie1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of Gene_or_gene_producttHe1: trigger-arg-path: Positive_activation >dobj [lemma='mek'] controlledtRe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >appos Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] Gene_or_gene_producttQe1: trigger-arg-path: enhance >dobj [lemma='mek'] controlled:Gene_or_gene_productt!interceding-token ngrams: stimulit@e1: trigger-arg-path: enhance >nsubj >appos Gene_or_gene_producttke1: trigger-arg-path: enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] controller:Gene_or_gene_producttVe1: trigger-arg-path: enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] controllertee1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='mek'] controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: enhance thethe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] controllert.interceding-token ngrams: to different stimulit`e1: trigger-arg-path: enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='mek'] controlled:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='mek'] Gene_or_gene_productt3e1: args2Role-mention-ngram: enhance the CONTROLLEDtPe1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='mek'] controlledt.interceding-token ngrams: signaling pathway intje1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controllertHe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >appos controllertTe1: trigger-arg-path: enhance:Positive_activation >nsubj >appos Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: ) enhancetLe1: trigger-arg-path: Positive_activation >nsubj >appos Gene_or_gene_productt/interceding-token ngrams: response to differentt.e1: ents2Label-mention-ngram: SHARED ) enhancetRe1: trigger-arg-path: Positive_activation >dobj [lemma='mek'] Gene_or_gene_productt_e1: trigger-arg-path: enhance:Positive_activation >nsubj >appos controller:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj controlledt6e1: trigger-arg-path: enhance >nsubj >appos controllert]e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >appos controller:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj Gene_or_gene_productt.e1: trigger-arg-path: enhance >dobj controlledt]e1: trigger-arg-path: Positive_activation >dobj [lemma='mek'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: enhance:Positive_activation >dobj Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER ) enhancetinterceding-token ngrams: [ , -tFe1: trigger-arg-path: enhance >dobj [lemma='mek'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj controlled:Gene_or_gene_producttCe1: trigger-arg-path: enhance >dobj controlled:Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controllert+e1: ents2Label-mention-ngram: ) enhance thet\e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >appos controllert-interceding-token ngrams: different stimuli [tNe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mek'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj Gene_or_gene_producttte1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='protein'] >appos [lemma='KSR'] controller:Gene_or_gene_productt%interceding-token ngrams: stimuli [ ,tBe1: trigger-arg-path: enhance:Positive_activation >dobj controlledtfe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >appos Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='mek'] controlledt#interceding-token ngrams: stimuli [tdobj [lemma='mek'] controlledt+interceding-token ngrams: different stimulitZe1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='mek'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlled:Gene_or_gene_productt&interceding-token ngrams: to differenttXe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mek'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mek'] controlled:Gene_or_gene_productt!interceding-token ngrams: ] . Thetwe1: trigger-arg-path: Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controller:Gene_or_gene_producttinterceding-token ngrams: , - ]tBe1: trigger-arg-path: Positive_activation >nsubj >appos controllert-interceding-token ngrams: pathway in responsetWe1: trigger-arg-path: Positive_activation >nsubj >appos controller:Gene_or_gene_producttKe1: trigger-arg-path: enhance >nsubj >appos controller:Gene_or_gene_producttfinterceding-tokens-full-span: and ERK signaling pathway in response to different stimuli [ , - ] . ThetWe1: trigger-arg-path: enhance:Positive_activation >dobj controlled:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj >appos controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controller:Gene_or_gene_productte1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controller:Gene_or_gene_producttle1: trigger-arg-path: Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: enhance thet*e1: args2Role-mention-ngram: ) enhance thet0e1: ents2Label-mention-ngram: enhance the SHAREDte1: trigger: enhancet$interceding-token ngrams: pathway intinterceding-token ngrams: [ ,t8e1: trigger-arg-path: enhance >dobj Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='protein'] >appos [lemma='KSR'] controllert&e1: args2Role-mention-ngram: ) enhancetJe1: trigger-arg-path: enhance:Positive_activation >nsubj >appos controllert"e1: ents2Label-mention-ngram: abletne2: trigger-arg-path: Positive_regulation nn [lemma='pml'] controlled:Phosphorylationtre1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >amod Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , caseintme2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] controlledtPe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn Phosphorylationt"interceding-token ngrams: of PML .t%e1: args2Role-mention-ngram: , caseint^e2: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_producttVe1: trigger-arg-path: phosphorylate:Positive_regulation nsubj >amod controllert,e1: args2Role-mention-ngram: casein kinase 2t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controller:Gene_or_gene_productt?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER , caseint e1: args2Role-mention-ngram: CK2t&e1: ents2Label-mention-ngram: , caseintDe2: trigger-arg-path: Positive_regulation nn Phosphorylationt#e1: ents2Label-mention-ngram: ( CK2t%e1: ents2Label-mention-ngram: is ablet*e2: ents2Label-mention-ngram: mutants thatt}e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >amod controller:Gene_or_gene_productt(interceding-token ngrams: Consequently ,t"e1: args2Role-mention-ngram: ( CK2t!e1: ents2Label-mention-ngram: 565tNe2: trigger-arg-path: phosphorylated:Positive_regulation nn controlledt%e1: args2Role-mention-ngram: kinase 2t?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controllert+e1: ents2Label-mention-ngram: casein kinasetJe2: trigger-arg-path: phosphorylated nn controlled:PhosphorylationtLe1: trigger-arg-path: phosphorylate nsubj >amod Gene_or_gene_productt}e2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] controlled:Phosphorylationt0interceding-token ngrams: and promote proteosomet3e2: ents2Label-mention-ngram: not be phosphorylatedt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: kinase 2t?e2: trigger-arg-path: phosphorylated nn Phosphorylationt(e1: ents2Label-mention-ngram: serine 565tSe2: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] controllertUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] controllertze2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] controlled:Phosphorylationt!e1: args2Role-mention-ngram: , ist:e2: trigger-arg-path: phosphorylated nn controlledt(e1: ents2Label-mention-ngram: is able totXe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] controllert2interceding-token ngrams: dependent degradation oft.e2: ents2Label-mention-ngram: mutants that cant:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mutantstie1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj >amod controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: be phosphorylatedtCe1: ents2Label-mention-ngram: to phosphorylate GENE_OR_GENE_PRODUCTt3e1: ents2Label-mention-ngram: able to phosphorylatetOe2: trigger-arg-path: Positive_regulation nn controlled:Phosphorylationt.interceding-token ngrams: proteosome dependentt^e2: trigger-arg-path: Positive_regulation nn [lemma='pml'] controlledt/interceding-token ngrams: dependent degradationt|e1: trigger-arg-path: Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controllert?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mutants thatt$e1: ents2Label-mention-ngram: ) , ist'e1: args2Role-mention-ngram: is able tot*CSSPATH: ROOT >xcomp ++ ROOT >nsubj >rcmodt$e1: ents2Label-mention-ngram: caseintve1: trigger-arg-path: phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controllert6interceding-token ngrams: promote proteosome dependenttNe2: trigger-arg-path: phosphorylated >agent [lemma='ck2'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controller:Gene_or_gene_producttinterceding-token ngrams: PML .t!e1: args2Role-mention-ngram: ablet&e1: args2Role-mention-ngram: , is abletce2: trigger-arg-path: Positive_regulation nn [lemma='pml'] Phosphorylationtie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] controllert,e1: args2Role-mention-ngram: , casein kinaset+e1: ents2Label-mention-ngram: on serine 565tTe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj >amod controllert%e1: ents2Label-mention-ngram: able totbe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn Phosphorylationt2e2: ents2Label-mention-ngram: be phosphorylated byt*e2: ents2Label-mention-ngram: that can nottKe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controlledt$e1: args2Role-mention-ngram: able tot#e1: args2Role-mention-ngram: ) , ist%e2: ents2Label-mention-ngram: mutantst(e2: ents2Label-mention-ngram: can not betHe1: trigger-arg-path: Positive_regulation nsubj >amod controllert?e1: trigger-arg-path: phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: casein kinase 2tCe1: ents2Label-mention-ngram: phosphorylate GENE_OR_GENE_PRODUCT ont:interceding-token ngrams: proteosome dependent degradationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controllert$e1: args2Role-mention-ngram: ( CK2 )tje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj >amod Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn controlled:Phosphorylationt*interceding-token ngrams: . Consequently ,tSe2: trigger-arg-path: phosphorylated:Positive_regulation nn PhosphorylationtYe2: trigger-arg-path: phosphorylated >agent [lemma='ck2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] Phosphorylationt*e1: args2Role-mention-ngram: casein kinasetWe1: trigger-arg-path: phosphorylate nsubj >amod controller:Gene_or_gene_productt?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: , istoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controlled:Phosphorylationt@e1: ents2Label-mention-ngram: phosphorylate GENE_OR_GENE_PRODUCTt#e1: args2Role-mention-ngram: caseintse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] Gene_or_gene_productt$interceding-token ngrams: proteosometBe1: trigger-arg-path: phosphorylate nsubj >amod controllertnsubj >amod controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] Phosphorylationt?e2: trigger-arg-path: Positive_regulation nn controlledt&interceding-token ngrams: Consequentlyt!e1: ents2Label-mention-ngram: CK2t?e1: trigger-arg-path: phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: , casein kinaset'e1: args2Role-mention-ngram: kinase 2 (t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: , is abletme2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: ( CK2 )tbinterceding-tokens-full-span: and promote proteosome dependent degradation of PML . Consequently ,t~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] controlledt%e1: ents2Label-mention-ngram: 2 ( CK2t$e2: ents2Label-mention-ngram: not bet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controllertje2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] controlledt]e1: trigger-arg-path: Positive_regulation nsubj >amod controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: 2 ( CK2t(e1: ents2Label-mention-ngram: kinase 2 (t(interceding-token ngrams: . Consequentlyt/e1: args2Role-mention-ngram: able to CONTROLLEDt%interceding-token ngrams: and promotet^e2: trigger-arg-path: phosphorylated:Positive_regulation nn controlled:Phosphorylationt`e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj >amod Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] controlled:Phosphorylationt"e1: args2Role-mention-ngram: CK2 )t?e1: trigger-arg-path: Positive_regulation nsubj [lemma='kinase'] >amod [lemma='oncogenic'] Gene_or_gene_producttRe1: trigger-arg-path: Positive_regulation nsubj >amod Gene_or_gene_productt#e1: ents2Label-mention-ngram: CK2 )tie2: trigger-arg-path: phosphorylated nn [lemma='pml'] controlled:Phosphorylationthe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >amod controllertYe2: trigger-arg-path: phosphorylated nn [lemma='pml'] controlledtDe2: trigger-arg-path: phosphorylated >agent [lemma='ck2'] controllert%e1: ents2Label-mention-ngram: CK2 ) ,t$e1: args2Role-mention-ngram: CK2 ) ,t&e2: ents2Label-mention-ngram: that cant$e1: args2Role-mention-ngram: is ablet,interceding-token ngrams: promote proteosomet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='kinase'] >amod [lemma='oncogenic'] controller:Gene_or_gene_productt^e2: trigger-arg-path: phosphorylated nn [lemma='pml'] Phosphorylationt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn controlledtre2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] Phosphorylationt4e1: trigger-arg-path: bind:Binding >prep_with Familyt#interceding-token ngrams: WorcestertRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='ra'] themet'interceding-token ngrams: Ras mutationst-e1: args2Role-mention-ngram: THEME would bindt'interceding-token ngrams: , we detectedt)interceding-token ngrams: and mediate Rast interceding-token ngrams: , MA )t%interceding-token ngrams: an antibodyt"e1: args2Role-mention-ngram: wouldt3e1: trigger-arg-path: bind:Binding >prep_with themet*interceding-token ngrams: characterized byt'e1: args2Role-mention-ngram: would bindt1interceding-token ngrams: the frequent occurrencet@e1: trigger-arg-path: bind:Binding >prep_with [lemma='ra'] themet&interceding-token ngrams: Ras activityt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] themet+interceding-token ngrams: mutations . Usingt$interceding-token ngrams: occurrencet+interceding-token ngrams: occurrence of Rast(e1: ents2Label-mention-ngram: would bindt,e1: args2Role-mention-ngram: bind with THEMEtPe2: trigger-arg-path: Binding >prep_between [lemma='gal-3'] Gene_or_gene_producttinterceding-token ngrams: MA )t&interceding-token ngrams: detected thetGe1: trigger-arg-path: bind:Binding >prep_with [lemma='ra'] theme:Familyt"interceding-token ngrams: Using antte2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt%interceding-token ngrams: mutations .tDe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with theme:Familyt%interceding-token ngrams: and mediatet-e1: ents2Label-mention-ngram: would bind withtZe2: trigger-arg-path: interaction >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt#e1: ents2Label-mention-ngram: wouldt'e1: ents2Label-mention-ngram: bind withtfe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] Gene_or_gene_productt*interceding-token ngrams: activity in PDACt-interceding-token ngrams: cells characterizedt?interceding-tokens-full-span: and mediate Ras activity in PDAC cells characterized by the frequent occurrence of Ras mutations . Using an antibody array ( Hypromatrix , Worcester , MA ) , we detected thet"interceding-token ngrams: frequentt0interceding-token ngrams: frequent occurrence oft-interceding-token ngrams: frequent occurrencet)interceding-token ngrams: Ras activity intVe2: trigger-arg-path: Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME wouldt'interceding-token ngrams: occurrence oft+e1: trigger-arg-path: bind >prep_with themet.e1: ents2Label-mention-ngram: bind with SHAREDt)interceding-token ngrams: Ras mutations .t8e1: trigger-arg-path: bind >prep_with [lemma='ra'] themet.interceding-token ngrams: mediate Ras activityt+interceding-token ngrams: an antibody arrayt'interceding-token ngrams: characterizedtSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='ra'] Familyt,e1: trigger-arg-path: bind >prep_with Familyt'interceding-token ngrams: in PDAC cellst%interceding-token ngrams: mediate Rast!interceding-token ngrams: in PDACt)interceding-token ngrams: ( Hypromatrix ,t interceding-token ngrams: ) , wetWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] themet%interceding-token ngrams: Worcester ,t\e2: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] Gene_or_gene_productt*interceding-token ngrams: antibody array (tEe2: trigger-arg-path: interaction >prep_between [lemma='gal-3'] themet)interceding-token ngrams: we detected thet*e1: ents2Label-mention-ngram: SHARED wouldtEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with themet'interceding-token ngrams: ( Hypromatrixt>e1: trigger-arg-path: lemmatizedTrigger=bind >prep_with Familyt*interceding-token ngrams: of Ras mutationstYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='ra'] theme:Familytinterceding-token ngrams: , MAt%interceding-token ngrams: HypromatrixtFe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with Familyt$interceding-token ngrams: . Using ant2interceding-token ngrams: PDAC cells characterizedt%interceding-token ngrams: , Worcestert$interceding-token ngrams: PDAC cellst?e1: trigger-arg-path: bind >prep_with [lemma='ra'] theme:Familyt=e1: trigger-arg-path: lemmatizedTrigger=bind >prep_with themetKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='ra'] Familyt&interceding-token ngrams: the frequentt!interceding-token ngrams: array (tbe2: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: SHARED would bindtne2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] Gene_or_gene_producttAe2: trigger-arg-path: Binding >prep_between [lemma='gal-3'] themet%interceding-token ngrams: we detectedt:e1: trigger-arg-path: bind:Binding >prep_with theme:Familyt+interceding-token ngrams: Using an antibodytAe1: trigger-arg-path: bind:Binding >prep_with [lemma='ra'] Familyt2e1: trigger-arg-path: bind >prep_with theme:Familyt)interceding-token ngrams: by the frequentt#interceding-token ngrams: mutationst(interceding-token ngrams: Worcester , MAt*CSSPATH: ROOT >ccomp ++ ROOT >ccomp >nsubjt1interceding-token ngrams: Hypromatrix , Worcestert'interceding-token ngrams: Hypromatrix ,t0interceding-token ngrams: cells characterized byt'interceding-token ngrams: , Worcester ,t9e1: trigger-arg-path: bind >prep_with [lemma='ra'] Familyt-interceding-token ngrams: array ( HypromatrixtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='ra'] themet interceding-token ngrams: MA ) ,tLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with theme:Familyt,e1: args2Role-mention-ngram: would bind withtQe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='ra'] theme:Familyt!interceding-token ngrams: mediatetTe2: trigger-arg-path: interaction >prep_between [lemma='gal-3'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] themetinterceding-token ngrams: PDACt.interceding-token ngrams: characterized by thetinterceding-token ngrams: MAt&e1: args2Role-mention-ngram: bind witht(interceding-token ngrams: , are involvedtne2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj >nn controlled:Gene_or_gene_productt1e2: args2Role-mention-ngram: suppressor , therebytYe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raptor'] Gene_or_gene_producttJe2: trigger-arg-path: activating >dobj >nn controlled:Gene_or_gene_producttOe1: trigger-arg-path: complexes >nn [lemma='raptor'] theme:Gene_or_gene_productt"interceding-token ngrams: the mTORtHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mtor'] themetze2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='kinase'] >nn [lemma='mtor'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: activating conj_and [lemma='suppressor'] >nn [lemma='raptor'] controller:Gene_or_gene_producttGe1: trigger-arg-path: Binding >nn [lemma='raptor'] Gene_or_gene_productt+interceding-token ngrams: Raptor complex byt(interceding-token ngrams: induced by Aktt$interceding-token ngrams: Akt kinaset*interceding-token ngrams: . The activationt?e2: trigger-arg-path: activating:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controllert0e2: ents2Label-mention-ngram: thereby activatingt%interceding-token ngrams: by IKKalphatOe2: trigger-arg-path: lemmatizedTrigger=activate conj_and >nn controllert^e2: trigger-arg-path: activating:Negative_activation >dobj >nn controlled:Gene_or_gene_productt+interceding-token ngrams: with IKKalpha andtinterceding-tokens-full-span: in response to TNFalpha and insulin , are involved with IKKalpha and IKKbeta . The activation of the mTOR and Raptor complex by IKKalpha was induced by Akt kinase , whereas IKKbeta repressed the tuberous sclerosis complex ( TSC ) , which is an mTOR andt(e2: ents2Label-mention-ngram: activatingt,interceding-token ngrams: and Raptor complextYe2: trigger-arg-path: lemmatizedTrigger=activate conj_and >nn Gene_or_gene_productt~e2: trigger-arg-path: activating conj_and [lemma='suppressor'] >nn [lemma='raptor'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='mtor'] theme:Gene_or_gene_productthe2: trigger-arg-path: activating:Negative_activation conj_and >nn controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=activate conj_and >nn controller:Gene_or_gene_productt)interceding-token ngrams: mTOR and Raptort_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtor'] Gene_or_gene_productt"interceding-token ngrams: mTOR andte2: trigger: activatingt1e2: ents2Label-mention-ngram: SHARED suppressor ,t@e1: trigger-arg-path: complexes:Binding >nn [lemma='mtor'] themetinterceding-token ngrams: TSC )t$interceding-token ngrams: is an mTORt#interceding-token ngrams: complex (t%interceding-token ngrams: and IKKbetatoe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='kinase'] >nn [lemma='mtor'] Gene_or_gene_producttWe1: trigger-arg-path: complexes:Binding >nn [lemma='raptor'] theme:Gene_or_gene_producttUe2: trigger-arg-path: activating >dobj [lemma='kinase'] >nn [lemma='mtor'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate conj_and [lemma='suppressor'] >nn [lemma='raptor'] Gene_or_gene_productt%interceding-token ngrams: and insulintxe2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and >nn controller:Gene_or_gene_productt0interceding-token ngrams: the tuberous sclerosist0interceding-token ngrams: repressed the tuberoustie2: trigger-arg-path: activating:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controllert/e2: ents2Label-mention-ngram: SHARED suppressort0interceding-token ngrams: involved with IKKalphat+interceding-token ngrams: IKKbeta repressedt?e2: trigger-arg-path: activating:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] Gene_or_gene_productt-interceding-token ngrams: sclerosis complex (tWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mtor'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: activating the SHAREDtje2: trigger-arg-path: activating >dobj [lemma='kinase'] >nn [lemma='mtor'] controlled:Gene_or_gene_productt(interceding-token ngrams: Raptor complext-interceding-token ngrams: complex by IKKalphat2e2: ents2Label-mention-ngram: suppressor , therebytPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtor'] themet?e2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj >nn controlledtSe2: trigger-arg-path: activating:Negative_activation >dobj >nn Gene_or_gene_productt_e2: trigger-arg-path: activating >dobj [lemma='kinase'] >nn [lemma='mtor'] Gene_or_gene_productt.interceding-token ngrams: TNFalpha and insulint2e2: args2Role-mention-ngram: CONTROLLER suppressortSe2: trigger-arg-path: activating:Negative_activation conj_and >nn controllert!interceding-token ngrams: TSC ) ,tae1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raptor'] Gene_or_gene_productt'interceding-token ngrams: repressed thet&interceding-token ngrams: IKKalpha andtEe1: trigger-arg-path: Binding >nn [lemma='mtor'] Gene_or_gene_productt%interceding-token ngrams: of the mTORt&interceding-token ngrams: TNFalpha andt*e2: ents2Label-mention-ngram: suppressor ,tMe1: trigger-arg-path: complexes >nn [lemma='mtor'] theme:Gene_or_gene_productt:CSSPATH: ROOT >nsubjpass ++ ROOT >advcl >dobj >rcmod >vmodtce2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj >nn Gene_or_gene_productt+interceding-token ngrams: are involved witht?e2: trigger-arg-path: activating >dobj >nn Gene_or_gene_producttinterceding-token ngrams: ( TSCtse2: trigger-arg-path: Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlled:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mtor'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: activating thet'interceding-token ngrams: by Akt kinaset%interceding-token ngrams: to TNFalphat'interceding-token ngrams: and IKKbeta .t#interceding-token ngrams: insulin ,tTe2: trigger-arg-path: activating conj_and >nn controller:Gene_or_gene_producttse2: trigger-arg-path: activating:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] Gene_or_gene_productt+e2: args2Role-mention-ngram: activating thet.interceding-token ngrams: IKKalpha was inducedt8e1: trigger-arg-path: complexes >nn [lemma='mtor'] themet?e2: trigger-arg-path: lemmatizedTrigger=activate conj_and [lemma='suppressor'] >nn [lemma='raptor'] controller:Gene_or_gene_producttte2: trigger-arg-path: activating conj_and [lemma='suppressor'] >nn [lemma='raptor'] controllert&interceding-token ngrams: are involvedt~e2: trigger-arg-path: activating:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlled:Gene_or_gene_productt&interceding-token ngrams: Akt kinase ,t]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mtor'] theme:Gene_or_gene_producttQe1: trigger-arg-path: complexes:Binding >nn [lemma='raptor'] Gene_or_gene_productt?e2: trigger-arg-path: activating:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controller:Gene_or_gene_productt(interceding-token ngrams: was induced byt4e2: args2Role-mention-ngram: CONTROLLER suppressor ,t_e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raptor'] theme:Gene_or_gene_productt'interceding-token ngrams: with IKKalphat+interceding-token ngrams: activation of thet'interceding-token ngrams: involved withtme2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and >nn Gene_or_gene_productt&interceding-token ngrams: IKKalpha wastce2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and >nn controllert8e1: trigger-arg-path: Binding >nn [lemma='raptor'] themet?e2: trigger-arg-path: activating conj_and >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: thereby activating thet)interceding-token ngrams: to TNFalpha andtBe1: trigger-arg-path: complexes:Binding >nn [lemma='raptor'] themetRe2: trigger-arg-path: Negative_activation conj_and >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlled:Gene_or_gene_productt%interceding-token ngrams: an mTOR andt!interceding-token ngrams: an mTORtOe1: trigger-arg-path: complexes:Binding >nn [lemma='mtor'] Gene_or_gene_productt}e2: trigger-arg-path: Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controllertIe2: trigger-arg-path: activating conj_and >nn Gene_or_gene_productt"interceding-token ngrams: TNFalphat$interceding-token ngrams: complex byt(interceding-token ngrams: The activationt?e2: trigger-arg-path: Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] Gene_or_gene_productt1e2: args2Role-mention-ngram: , thereby activatingt5e2: trigger-arg-path: activating >dobj >nn controlledt?e2: trigger-arg-path: Negative_activation conj_and [lemma='suppressor'] >nn [lemma='raptor'] controller:Gene_or_gene_productt'interceding-token ngrams: insulin , aret6e2: args2Role-mention-ngram: activating the CONTROLLEDtee2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='kinase'] >nn [lemma='mtor'] controlledt&interceding-token ngrams: the mTOR andt+interceding-token ngrams: , whereas IKKbetat)interceding-token ngrams: by IKKalpha wast2e2: ents2Label-mention-ngram: , thereby activatingt$interceding-token ngrams: and RaptortUe1: trigger-arg-path: complexes:Binding >nn [lemma='mtor'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Negative_activation conj_and >nn controllert&interceding-token ngrams: the tuberoust"interceding-token ngrams: kinase ,t*interceding-token ngrams: kinase , whereasthe2: trigger-arg-path: Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] Gene_or_gene_productt"interceding-token ngrams: involvedtMe1: trigger-arg-path: Binding >nn [lemma='raptor'] theme:Gene_or_gene_productt+interceding-token ngrams: The activation oft%interceding-token ngrams: was inducedt.interceding-token ngrams: response to TNFalphatGe1: trigger-arg-path: complexes >nn [lemma='mtor'] Gene_or_gene_productt)e2: args2Role-mention-ngram: suppressor ,t'interceding-token ngrams: and insulin ,t^e2: trigger-arg-path: Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlledt'interceding-token ngrams: IKKbeta . Thet6e1: trigger-arg-path: Binding >nn [lemma='mtor'] themet interceding-token ngrams: Raptort'interceding-token ngrams: complex ( TSCtIe1: trigger-arg-path: complexes >nn [lemma='raptor'] Gene_or_gene_productt:e1: trigger-arg-path: complexes >nn [lemma='raptor'] themet interceding-token ngrams: by Aktt)interceding-token ngrams: whereas IKKbetat3e2: args2Role-mention-ngram: thereby activating thetge1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raptor'] theme:Gene_or_gene_productt!interceding-token ngrams: ( TSC )tRe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='raptor'] themet#interceding-token ngrams: IKKbeta .t.interceding-token ngrams: IKKalpha and IKKbetatIe2: trigger-arg-path: activating:Negative_activation >dobj >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate conj_and [lemma='suppressor'] >nn [lemma='raptor'] controllert'e2: args2Role-mention-ngram: activatingt#interceding-token ngrams: repressedt]e2: trigger-arg-path: activating:Negative_activation conj_and >nn Gene_or_gene_productt]e2: trigger-arg-path: Negative_activation conj_and >nn controller:Gene_or_gene_producttinterceding-token ngrams: TSCt!interceding-token ngrams: IKKbetatye2: trigger-arg-path: lemmatizedTrigger=activate:Negative_activation >dobj [lemma='kinase'] >nn [lemma='mtor'] controlledtJe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='raptor'] themet#interceding-token ngrams: ) , whicht/e2: args2Role-mention-ngram: thereby activatingt/interceding-token ngrams: IKKbeta repressed thet3interceding-token ngrams: whereas IKKbeta repressedtTe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] Generic_entityt interceding-token ngrams: ( JNK1t%interceding-token ngrams: therefore ,t3interceding-token ngrams: JNK phosphorylation sitestSe2: trigger-arg-path: associates >prep_with [lemma='beclin-1'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] theme:Generic_entityt interceding-token ngrams: causestae2: trigger-arg-path: associates:Binding >prep_with [lemma='beclin-1'] theme:Gene_or_gene_productt6e2: args2Role-mention-ngram: constitutively associatestnsubj Generic_entityt interceding-token ngrams: JNK1 )t&interceding-token ngrams: Beclin and 1tDe2: trigger-arg-path: associates:Binding >nsubj theme:Generic_entitytZe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] theme:Generic_entitytVe2: trigger-arg-path: Binding >prep_with [lemma='beclin-1'] theme:Gene_or_gene_producttae1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='beclin-1'] themet%interceding-token ngrams: sites and ,tinterceding-token ngrams: and 1t;e2: args2Role-mention-ngram: constitutively associates witht&interceding-token ngrams: which causest)interceding-token ngrams: and , thereforet,interceding-token ngrams: lacks the relevantt\e1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] controller:Gene_or_gene_producttGe1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] controllert"interceding-token ngrams: relevanttYe2: trigger-arg-path: associates >prep_with [lemma='beclin-1'] theme:Gene_or_gene_producttBe2: ents2Label-mention-ngram: associates with GENE_OR_GENE_PRODUCTt&interceding-token ngrams: complex . Int-e2: ents2Label-mention-ngram: associates witht/interceding-token ngrams: phosphorylation sitest-interceding-token ngrams: JNK phosphorylationt3interceding-token ngrams: phosphorylation sites andt>e2: trigger-arg-path: associates:Binding >nsubj Generic_entitytNe2: trigger-arg-path: associates:Binding >prep_with theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='beclin-1'] theme:Gene_or_gene_productt1e2: trigger-arg-path: associates >prep_with themet,e2: args2Role-mention-ngram: associates witht(interceding-token ngrams: , vBcl-2 lackst\e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] Generic_entitytve1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj Generic_entityt7e2: ents2Label-mention-ngram: constitutively associatestBe2: trigger-arg-path: associates:Binding >nsubj [lemma='it'] themetLe2: trigger-arg-path: associates:Binding >prep_with [lemma='beclin-1'] themetKe2: trigger-arg-path: associates:Binding >nsubj [lemma='it'] Generic_entityt6interceding-token ngrams: relevant JNK phosphorylationt'interceding-token ngrams: disruption oftnsubj [lemma='it'] themetinterceding-token ngrams: lackst%interceding-token ngrams: , thereforetHe2: trigger-arg-path: associates:Binding >prep_with Gene_or_gene_productt'e2: args2Role-mention-ngram: associatestIe2: trigger-arg-path: associates >nsubj [lemma='it'] theme:Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] controller:Gene_or_gene_productt*interceding-token ngrams: the relevant JNKt>e2: ents2Label-mention-ngram: SHARED constitutively associatest(interceding-token ngrams: , which causestPe2: trigger-arg-path: Binding >prep_with [lemma='beclin-1'] Gene_or_gene_productt$interceding-token ngrams: the cBcl-2t"interceding-token ngrams: 1 ( JNK1t'interceding-token ngrams: of the cBcl-2t&interceding-token ngrams: relevant JNKtle2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='beclin-1'] Gene_or_gene_productt&interceding-token ngrams: the cBcl-2 /tinterceding-token ngrams: 1 (t.interceding-token ngrams: causes disruption oftme1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='beclin-1'] Gene_or_gene_producttDe2: trigger-arg-path: associates >prep_with [lemma='beclin-1'] themet CSSPATH: ROOT  ++ ROOT >conj_andt(e2: ents2Label-mention-ngram: associatestbe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] Gene_or_gene_productt@e2: trigger-arg-path: associates >prep_with Gene_or_gene_productt)interceding-token ngrams: cBcl-2 / BeclintSe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] themetQe2: trigger-arg-path: associates:Binding >nsubj [lemma='it'] theme:Generic_entityt5e2: trigger-arg-path: associates:Binding >nsubj themete2: trigger: associatest+interceding-token ngrams: disruption of thetMe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj theme:Generic_entityt&interceding-token ngrams: / Beclin andtre2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='beclin-1'] theme:Gene_or_gene_productt?interceding-tokens-full-span: 1 ( JNK1 ) , which causes disruption of the cBcl-2 / Beclin and 1 complex . In contrast , vBcl-2 lacks the relevant JNK phosphorylation sites and , therefore ,t"interceding-token ngrams: , vBcl-2t interceding-token ngrams: cBcl-2t9e2: trigger-arg-path: associates:Binding >prep_with themetCe2: trigger-arg-path: associates >nsubj [lemma='it'] Generic_entityt6e2: trigger-arg-path: associates >nsubj Generic_entitytee1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] Gene_or_gene_productt#interceding-token ngrams: lacks thet&interceding-token ngrams: the relevanttLe1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] controllert[e2: trigger-arg-path: associates:Binding >prep_with [lemma='beclin-1'] Gene_or_gene_producttpe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] controller:Gene_or_gene_productt+interceding-token ngrams: contrast , vBcl-2t%interceding-token ngrams: 1 complex .t1interceding-token ngrams: which causes disruptiont#interceding-token ngrams: sites andt"interceding-token ngrams: ( JNK1 )t&interceding-token ngrams: vBcl-2 lackstnsubj theme:Generic_entityt'interceding-token ngrams: and 1 complextUe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj theme:Generic_entitytle1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] controllert]e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='beclin-1'] themetFe2: trigger-arg-path: associates >prep_with theme:Gene_or_gene_productt[e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] controllertQe1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] Gene_or_gene_producttinterceding-token ngrams: JNK1tXe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] controllert1e2: args2Role-mention-ngram: THEME constitutivelytAe2: trigger-arg-path: Binding >prep_with [lemma='beclin-1'] themet"interceding-token ngrams: cBcl-2 /tKe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] themet*interceding-token ngrams: vBcl-2 lacks thetVe1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] Gene_or_gene_productt-e2: trigger-arg-path: associates >nsubj themet2e2: args2Role-mention-ngram: associates with THEMEt"interceding-token ngrams: pathwayst;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediatest!e1: args2Role-mention-ngram: lungt.interceding-token ngrams: This study suggestedt*interceding-token ngrams: the PI3K/AKT/PKBt(interceding-token ngrams: in lung cancert'interceding-token ngrams: might inhibittJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] controllert-interceding-token ngrams: promoting apoptosist?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt/interceding-token ngrams: suggested that IGFBP3t&interceding-token ngrams: IGFBP3 mightt+e1: ents2Label-mention-ngram: inhibits lungt'e1: args2Role-mention-ngram: metaplasiat+e1: args2Role-mention-ngram: decreasing thet)e1: args2Role-mention-ngram: upregulatingtte1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt!interceding-token ngrams: in lungtinterceding-token ngrams: mighttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_productt*interceding-token ngrams: pathways in lungt-interceding-token ngrams: and the Ras/Raf/MAPt(e2: ents2Label-mention-ngram: serine 136t5interceding-token ngrams: thereby promoting apoptosist$interceding-token ngrams: signallingt0interceding-token ngrams: the Ras/Raf/MAP kinaset.interceding-token ngrams: PI3K/AKT/PKB and thet-interceding-token ngrams: , thereby promotingt?interceding-tokens-full-span: , thereby promoting apoptosis and inhibiting cell proliferation . This study suggested that IGFBP3 might inhibit both the PI3K/AKT/PKB and the Ras/Raf/MAP kinase signalling pathways in lung cancer cells , ast'interceding-token ngrams: apoptosis andt+e2: ents2Label-mention-ngram: on serine 136t-interceding-token ngrams: signalling pathwayst_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_productt1interceding-token ngrams: promoting apoptosis andt#interceding-token ngrams: suggestedt+e1: ents2Label-mention-ngram: metaplasia byt.e1: args2Role-mention-ngram: by decreasing thetSe2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pi3k'] controllert|e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt$e1: ents2Label-mention-ngram: and bythe2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_productt/interceding-token ngrams: both the PI3K/AKT/PKBt5e1: ents2Label-mention-ngram: treatment inhibits lungt)interceding-token ngrams: study suggestedtfe1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert(interceding-token ngrams: and inhibitingt*e1: args2Role-mention-ngram: inhibits lungt$CSSPATH: ROOT  ++ ROOT >ccomp >advclt#interceding-token ngrams: promotingt*e1: ents2Label-mention-ngram: upregulatingt,e1: args2Role-mention-ngram: by upregulatingt7interceding-token ngrams: inhibiting cell proliferationt%interceding-token ngrams: Ras/Raf/MAPt/e1: ents2Label-mention-ngram: and by decreasingtde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pi3k'] controllert$e1: ents2Label-mention-ngram: IGFBP3t`e1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt5e1: ents2Label-mention-ngram: upregulating IGFBP3 andt(interceding-token ngrams: suggested thatt+interceding-token ngrams: kinase signallingt.interceding-token ngrams: IGFBP3 might inhibitt%interceding-token ngrams: lung cancert#e1: args2Role-mention-ngram: IGFBP3t+e1: ents2Label-mention-ngram: IGFBP3 and bytTe2: trigger-arg-path: mediates >nsubj [lemma='pi3k'] controller:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pi3k'] controllert/e1: args2Role-mention-ngram: lung metaplasia byt1e1: ents2Label-mention-ngram: upregulating IGFBP3t,e1: ents2Label-mention-ngram: decreasing thet)interceding-token ngrams: inhibiting cellt,interceding-token ngrams: Ras/Raf/MAP kinaset+e1: ents2Label-mention-ngram: by decreasingt#e1: args2Role-mention-ngram: and bytqe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt!e2: ents2Label-mention-ngram: 136t$interceding-token ngrams: inhibitingt?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediates thet?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt&interceding-token ngrams: inhibit bothtye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pi3k'] controller:Gene_or_gene_producttke1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt2interceding-token ngrams: apoptosis and inhibitingt6e1: args2Role-mention-ngram: decreasing the CONTROLLEDt"e1: ents2Label-mention-ngram: lungtinterceding-token ngrams: lungt4e1: args2Role-mention-ngram: treatment inhibits lungtIe2: trigger-arg-path: mediates >nsubj [lemma='pi3k'] Gene_or_gene_productt,e1: args2Role-mention-ngram: lung metaplasiat4interceding-token ngrams: kinase signalling pathwayst@e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL treatment inhibitst0e1: ents2Label-mention-ngram: lung metaplasia bytZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pi3k'] Gene_or_gene_producttoe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllertnsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert*e1: args2Role-mention-ngram: metaplasia byt7e1: args2Role-mention-ngram: metaplasia by upregulatingt6e1: ents2Label-mention-ngram: inhibits lung metaplasiatve1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt3e1: args2Role-mention-ngram: by upregulating IGFBP3t*e1: args2Role-mention-ngram: by decreasingt[e1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert+interceding-token ngrams: lung cancer cellst&interceding-token ngrams: . This studyt0e1: args2Role-mention-ngram: upregulating IGFBP3t(e1: ents2Label-mention-ngram: decreasingt-interceding-token ngrams: and inhibiting cellt?e2: trigger-arg-path: mediates >nsubj [lemma='pi3k'] controllert.interceding-token ngrams: the PI3K/AKT/PKB andt)interceding-token ngrams: the Ras/Raf/MAPt+interceding-token ngrams: thereby promotingt4e1: ents2Label-mention-ngram: by upregulating IGFBP3tle1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert7interceding-token ngrams: Ras/Raf/MAP kinase signallingt5e1: args2Role-mention-ngram: inhibits lung metaplasiat*interceding-token ngrams: inhibit both thet7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL treatmentt8e1: ents2Label-mention-ngram: metaplasia by upregulatingtee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pi3k'] controller:Gene_or_gene_productt]e2: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_productt.interceding-token ngrams: proliferation . Thist'e1: args2Role-mention-ngram: IGFBP3 andt$interceding-token ngrams: This studyt'e1: args2Role-mention-ngram: decreasingt%interceding-token ngrams: pathways int(e1: ents2Label-mention-ngram: IGFBP3 andt&interceding-token ngrams: PI3K/AKT/PKBt+interceding-token ngrams: that IGFBP3 mightte1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt-e1: ents2Label-mention-ngram: lung metaplasiat.e1: args2Role-mention-ngram: and by decreasingt*interceding-token ngrams: PI3K/AKT/PKB andtTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pi3k'] Gene_or_gene_productt,interceding-token ngrams: might inhibit botht interceding-token ngrams: IGFBP3tke1: trigger-arg-path: inhibits >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt%interceding-token ngrams: that IGFBP3t.interceding-token ngrams: study suggested thatt0interceding-token ngrams: signalling pathways int(e1: ents2Label-mention-ngram: metaplasiat(interceding-token ngrams: . Altogether ,t&interceding-token ngrams: mitochondriatke2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt-e2: args2Role-mention-ngram: invasion throughtUe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='p53krkkk'] controllert interceding-token ngrams: Omi int]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] Familyt%e2: args2Role-mention-ngram: invasiont?e2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt)interceding-token ngrams: the invasion oftXe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='p53krkkk'] controllert-interceding-token ngrams: Omi in mitochondriat*e2: args2Role-mention-ngram: cell invasiontue2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productt4interceding-token ngrams: mitochondria and decreasedt&interceding-token ngrams: Altogether ,t1e2: ents2Label-mention-ngram: increasing p38 MAPKt?interceding-tokens-full-span: and Omi in mitochondria and decreased the invasion of Ras transformed p53 -/ - MEFs . Altogether , these results suggest that cytoplasmic p53 restrictst'interceding-token ngrams: decreased thet0interceding-token ngrams: decreased the invasiont1e2: ents2Label-mention-ngram: FAMILY induced cellt)interceding-token ngrams: in mitochondriat?e2: trigger-arg-path: induced:Positive_activation >nsubj Familyt'interceding-token ngrams: these resultst-interceding-token ngrams: Ras transformed p53the2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt9e2: ents2Label-mention-ngram: invasion through increasingtje1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='p53krkkk'] controller:Gene_or_gene_productt.interceding-token ngrams: that cytoplasmic p53t7e1: ents2Label-mention-ngram: increased phosphorylationt&interceding-token ngrams: suggest thatt&e2: ents2Label-mention-ngram: invasiont,e2: ents2Label-mention-ngram: increasing p38t*interceding-token ngrams: that cytoplasmict-interceding-token ngrams: in mitochondria andt2e2: args2Role-mention-ngram: cell invasion throught*e2: ents2Label-mention-ngram: induced celltinterceding-token ngrams: -/ -t+e2: ents2Label-mention-ngram: cell invasiont interceding-token ngrams: - MEFstOe2: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] controller:Familyt%e2: args2Role-mention-ngram: p38 MAPKtYe1: trigger-arg-path: increased >nsubj [lemma='p53krkkk'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='p53krkkk'] controllertae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] controllert"interceding-token ngrams: - MEFs .t4e2: ents2Label-mention-ngram: through increasing p38tWe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt4e2: args2Role-mention-ngram: CONTROLLER induced cellt0e2: args2Role-mention-ngram: increasing p38 MAPKt!e2: ents2Label-mention-ngram: p38t2e2: args2Role-mention-ngram: induced cell invasiont.interceding-token ngrams: results suggest thattre2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productt)interceding-token ngrams: transformed p53t4e2: args2Role-mention-ngram: MAPK induced CONTROLLEDt+e2: args2Role-mention-ngram: increasing p38t)interceding-token ngrams: Ras transformedtme2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_producttae2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] controller:Familyt&interceding-token ngrams: the invasiont)interceding-token ngrams: cytoplasmic p53txe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: through increasingtinterceding-token ngrams: Omit)interceding-token ngrams: results suggestt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt&e2: ents2Label-mention-ngram: p38 MAPKtLe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='ra'] Familytme1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='p53krkkk'] controller:Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p53krkkk'] controllert%e2: ents2Label-mention-ngram: throughtXe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p53krkkk'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj FamilytNe1: trigger-arg-path: increased >nsubj [lemma='p53krkkk'] Gene_or_gene_productt/e2: args2Role-mention-ngram: through increasingt_e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='p53krkkk'] Gene_or_gene_productt8e2: args2Role-mention-ngram: invasion through increasingt+interceding-token ngrams: and decreased thet~e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='p53krkkk'] controller:Gene_or_gene_productt+interceding-token ngrams: MEFs . Altogethert&interceding-token ngrams: . Altogethert'interceding-token ngrams: and decreasedtPe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='ra'] controllert%interceding-token ngrams: invasion oft"interceding-token ngrams: p53 -/ -t.e2: ents2Label-mention-ngram: p38 MAPK inducedt.e2: ents2Label-mention-ngram: invasion throughtinterceding-token ngrams: -/tDe2: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] Familyt,interceding-token ngrams: transformed p53 -/tLe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT increased phosphorylationt*interceding-token ngrams: mitochondria andt*e2: ents2Label-mention-ngram: MAPK inducedt)interceding-token ngrams: , these resultst$CSSPATH: ROOT  ++ ROOT >ccomp >ccompt)e2: args2Role-mention-ngram: induced celltce1: trigger-arg-path: Positive_regulation >nsubj [lemma='p53krkkk'] controller:Gene_or_gene_producttHe2: trigger-arg-path: Positive_activation >nsubj [lemma='ra'] controllert,interceding-token ngrams: Altogether , theset$interceding-token ngrams: Altogethert,interceding-token ngrams: of Ras transformedtWe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='ra'] controller:Familyt1e2: ents2Label-mention-ngram: MAPK induced SHAREDt2interceding-token ngrams: suggest that cytoplasmict)interceding-token ngrams: invasion of Rast!interceding-token ngrams: and Omit e2: args2Role-mention-ngram: p38t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: induced cell invasiontce2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt#interceding-token ngrams: -/ - MEFst3interceding-token ngrams: cytoplasmic p53 restrictst-e2: args2Role-mention-ngram: p38 MAPK inducedt interceding-token ngrams: p53 -/t3e2: ents2Label-mention-ngram: cell invasion throught3e2: args2Role-mention-ngram: through increasing p38tJe2: trigger-arg-path: induced:Positive_activation >nsubj controller:Familyt[e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Familyt"interceding-token ngrams: invasiont$e2: args2Role-mention-ngram: throught)e2: args2Role-mention-ngram: MAPK inducedt|e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt/interceding-token ngrams: these results suggestt'interceding-token ngrams: p53 restrictst:e1: ents2Label-mention-ngram: increased phosphorylation oftDe1: trigger-arg-path: increased >nsubj [lemma='p53krkkk'] controllertse1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='p53krkkk'] Gene_or_gene_producttle2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt!interceding-token ngrams: suggestt$interceding-token ngrams: and Omi intbe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='p53krkkk'] Gene_or_gene_productt%interceding-token ngrams: and DIA-BLOt'interceding-token ngrams: ) by reducingt!interceding-token ngrams: ; and (t$interceding-token ngrams: by formingtUe1: trigger-arg-path: Binding >prep_between [lemma='smac'] theme:Gene_or_gene_productt$interceding-token ngrams: mutant maytHe2: trigger-arg-path: interaction >prep_between [lemma='survivin'] themetbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] theme:Gene_or_gene_productt_e2: trigger-arg-path: interaction:Binding >prep_between [lemma='survivin'] Gene_or_gene_productt$interceding-token ngrams: survivin ,t*interceding-token ngrams: Therefore , T34At/interceding-token ngrams: distinct mechanisms :tme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] Gene_or_gene_producttinterceding-token ngrams: ; andtse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] theme:Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='smac'] themet&interceding-token ngrams: reducing thet'interceding-token ngrams: and DIA-BLO .tUe2: trigger-arg-path: Binding >prep_between [lemma='smac'] theme:Gene_or_gene_productt-interceding-token ngrams: distinct mechanismstinterceding-token ngrams: and (tinterceding-token ngrams: T34At#interceding-token ngrams: wild-typet+interceding-token ngrams: may induce cancert+interceding-token ngrams: cancer cell deatht.interceding-token ngrams: C84A survivin mutantt.interceding-token ngrams: through two distincttXe1: trigger-arg-path: interactions >prep_between [lemma='survivin'] Gene_or_gene_productt]e2: trigger-arg-path: interaction >prep_between [lemma='survivin'] theme:Gene_or_gene_productt+interceding-token ngrams: death through twot@e1: trigger-arg-path: Binding >prep_between [lemma='smac'] themetke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] theme:Gene_or_gene_productt.interceding-token ngrams: heterodimer with thet%interceding-token ngrams: cancer cellt"interceding-token ngrams: survivint[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='smac'] Gene_or_gene_productt-interceding-token ngrams: DIA-BLO . Thereforetinterceding-token ngrams: ( 2 )t#interceding-token ngrams: Thereforet'interceding-token ngrams: C84A survivintDe1: trigger-arg-path: Binding >prep_between [lemma='survivin'] themet%interceding-token ngrams: by reducingt)interceding-token ngrams: by reducing thet$interceding-token ngrams: , T34A andt&interceding-token ngrams: mechanisms :t+interceding-token ngrams: mutant may inducetSe1: trigger-arg-path: Binding >prep_between [lemma='survivin'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_between [lemma='smac'] Gene_or_gene_producttinterceding-tokens-full-span: and DIA-BLO . Therefore , T34A and C84A survivin mutant may induce cancer cell death through two distinct mechanisms : ( 1 ) by forming a heterodimer with the wild-type survivin , leading to the reduced interaction with caspase-9 ; and ( 2 ) by reducing thetZe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] themet^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] themetee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] Gene_or_gene_productt"interceding-token ngrams: reducingt^e1: trigger-arg-path: interactions >prep_between [lemma='survivin'] theme:Gene_or_gene_productt%interceding-token ngrams: Therefore ,t$interceding-token ngrams: mechanismst0interceding-token ngrams: the wild-type survivint)interceding-token ngrams: survivin mutanttinterceding-token ngrams: twotinterceding-token ngrams: 1 )tDe2: trigger-arg-path: Binding >prep_between [lemma='survivin'] themet(interceding-token ngrams: mechanisms : (tIe1: trigger-arg-path: interactions >prep_between [lemma='survivin'] themetinterceding-token ngrams: ( 2t%interceding-token ngrams: . Thereforetbe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] themet*interceding-token ngrams: heterodimer witht'interceding-token ngrams: . Therefore ,t&interceding-token ngrams: two distinctt'interceding-token ngrams: a heterodimert1interceding-token ngrams: the reduced interactiont!interceding-token ngrams: and ( 2t&interceding-token ngrams: by forming atYe1: trigger-arg-path: Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_productt"interceding-token ngrams: T34A andtDe2: trigger-arg-path: interaction >prep_between [lemma='smac'] themetbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] themetwe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_productt,interceding-token ngrams: cell death throught%interceding-token ngrams: caspase-9 ;t1interceding-token ngrams: two distinct mechanismstinterceding-token ngrams: : (t`e1: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_between [lemma='smac'] Gene_or_gene_productt'interceding-token ngrams: the wild-typetinterceding-token ngrams: ( 1 )t#interceding-token ngrams: DIA-BLO .t4interceding-token ngrams: interaction with caspase-9t#interceding-token ngrams: caspase-9tYe2: trigger-arg-path: interaction >prep_between [lemma='smac'] theme:Gene_or_gene_producttZe1: trigger-arg-path: interactions >prep_between [lemma='smac'] theme:Gene_or_gene_producttYe2: trigger-arg-path: Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] themet'interceding-token ngrams: death throughtVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] themet interceding-token ngrams: 1 ) byt-interceding-token ngrams: survivin mutant mayt/interceding-token ngrams: forming a heterodimert,interceding-token ngrams: wild-type survivintse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] theme:Gene_or_gene_producttae2: trigger-arg-path: interaction:Binding >prep_between [lemma='smac'] theme:Gene_or_gene_productt*interceding-token ngrams: with caspase-9 ;twe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_productt2interceding-token ngrams: reduced interaction withtWe2: trigger-arg-path: interaction >prep_between [lemma='survivin'] Gene_or_gene_producttQe1: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] themet$interceding-token ngrams: may inducet+interceding-token ngrams: and C84A survivintinterceding-token ngrams: ( 1t,interceding-token ngrams: induce cancer cellt-interceding-token ngrams: reduced interactiont\e1: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] Gene_or_gene_productt,interceding-token ngrams: with the wild-typet!interceding-token ngrams: DIA-BLOtSe2: trigger-arg-path: Binding >prep_between [lemma='survivin'] Gene_or_gene_producttEe1: trigger-arg-path: interactions >prep_between [lemma='smac'] themetie1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] Gene_or_gene_productt)interceding-token ngrams: caspase-9 ; andt interceding-token ngrams: , T34At'interceding-token ngrams: T34A and C84Atinterceding-token ngrams: : ( 1t interceding-token ngrams: 2 ) bytinterceding-token ngrams: ) bytoe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interaction >prep_between [lemma='smac'] Gene_or_gene_productt&interceding-token ngrams: ) by formingtke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] themetee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='smac'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] Gene_or_gene_productt(interceding-token ngrams: with caspase-9t%interceding-token ngrams: the reducedt@e2: trigger-arg-path: Binding >prep_between [lemma='smac'] themetqe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='survivin'] Gene_or_gene_producttMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] themet.interceding-token ngrams: wild-type survivin ,tTe1: trigger-arg-path: interactions >prep_between [lemma='smac'] Gene_or_gene_productt"interceding-token ngrams: distincttfe1: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_producttinterceding-token ngrams: C84AtPe2: trigger-arg-path: interaction:Binding >prep_between [lemma='survivin'] themetme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='smac'] Gene_or_gene_productt,interceding-token ngrams: a heterodimer withtinterceding-token ngrams: 2 )t'interceding-token ngrams: induce cancertee2: trigger-arg-path: interaction:Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] themetDCSSPATH: ROOT >conj_and >dobj ++ ROOT >prepc_by >dep >prepc_by >dobjt"interceding-token ngrams: and C84At,interceding-token ngrams: survivin , leadingtoe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='survivin'] theme:Gene_or_gene_productt%interceding-token ngrams: through twot(interceding-token ngrams: to the reducedt?e1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlled:Gene_or_gene_producttJe1: trigger-arg-path: direct:Positive_activation >dobj >prep_of controlledt#interceding-token ngrams: unclear ,t&interceding-token ngrams: . It remainst+interceding-token ngrams: remains unclear ,tYe1: trigger-arg-path: direct >nsubj [lemma='scaffolding'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='akt'] Gene_or_gene_productt#interceding-token ngrams: or both .t&interceding-token ngrams: or limit itst!interceding-token ngrams: the PAKtSe2: trigger-arg-path: complex:Binding dobj [lemma='specificity'] >prep_of [lemma='akt'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='akt'] themetRe2: trigger-arg-path: complex:Binding >nn [lemma='akt'] theme:Gene_or_gene_productt6e1: trigger-arg-path: direct >dobj >prep_of controlledtinterceding-token ngrams: , howt interceding-token ngrams: both .tee2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='akt'] themet7e1: ents2Label-mention-ngram: the substrate specificitytqe1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttWe1: trigger-arg-path: direct:Positive_activation >nsubj controller:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='akt'] Gene_or_gene_producttne1: trigger-arg-path: direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlledtDe1: trigger-arg-path: direct >nsubj [lemma='scaffolding'] controllertYe2: trigger-arg-path: complex:Binding nsubj [lemma='scaffolding'] controller:Gene_or_gene_productt|e1: trigger-arg-path: Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: might direct thet!interceding-token ngrams: towardst,e1: ents2Label-mention-ngram: specificity oft@e1: trigger-arg-path: lemmatizedTrigger=direct >nsubj controllert3interceding-token ngrams: its accessibility towardst)interceding-token ngrams: remains uncleart"interceding-token ngrams: or limitt,interceding-token ngrams: It remains uncleartfe1: trigger-arg-path: Positive_activation >nsubj [lemma='scaffolding'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: substrate specificity oft#interceding-token ngrams: both . Itt!interceding-token ngrams: how thet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='akt'] Gene_or_gene_productt(interceding-token ngrams: its substratestqe1: trigger-arg-path: Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj >prep_of Gene_or_gene_producttKe2: trigger-arg-path: Binding dobj [lemma='specificity'] >prep_of [lemma='akt'] controlled:Gene_or_gene_producttCe1: trigger-arg-path: direct >nsubj controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=direct >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlledt]e1: trigger-arg-path: lemmatizedTrigger=direct >dobj >prep_of controlled:Gene_or_gene_producttQe1: trigger-arg-path: Positive_activation >nsubj [lemma='scaffolding'] controllertke1: trigger-arg-path: lemmatizedTrigger=direct >nsubj [lemma='scaffolding'] controller:Gene_or_gene_productt*interceding-token ngrams: towards a subsett5e1: args2Role-mention-ngram: substrate specificity oftJe1: trigger-arg-path: lemmatizedTrigger=direct >nsubj Gene_or_gene_producttnsubj controllertoe1: trigger-arg-path: direct >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlled:Gene_or_gene_productt3e1: ents2Label-mention-ngram: specificity of SHAREDtme1: trigger-arg-path: direct:Positive_activation >nsubj [lemma='scaffolding'] controller:Gene_or_gene_producttinterceding-token ngrams: limitt%interceding-token ngrams: how the PAKtGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='akt'] themet)e1: args2Role-mention-ngram: might directt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mighttxe1: trigger-arg-path: direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] Gene_or_gene_productt4e1: args2Role-mention-ngram: CONTROLLER might directtnn [lemma='akt'] themetQe2: trigger-arg-path: Binding nsubj [lemma='scaffolding'] Gene_or_gene_productt-e1: args2Role-mention-ngram: might direct thet#interceding-token ngrams: , how thet+e1: ents2Label-mention-ngram: the substratet)e1: ents2Label-mention-ngram: specificityt+interceding-token ngrams: its accessibilityt[e1: trigger-arg-path: Positive_activation >nsubj [lemma='scaffolding'] Gene_or_gene_productt5e2: trigger-arg-path: complex >nn [lemma='akt'] themetve1: trigger-arg-path: lemmatizedTrigger=direct >dobj [lemma='specificity'] >prep_of [lemma='akt'] Gene_or_gene_producttXe1: trigger-arg-path: direct:Positive_activation >nsubj [lemma='scaffolding'] controllert6e1: args2Role-mention-ngram: the substrate specificitytRe1: trigger-arg-path: lemmatizedTrigger=direct >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlled:Gene_or_gene_productt+interceding-token ngrams: of its substratest1interceding-token ngrams: accessibility towards at\e1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj >prep_of controlledt_e1: trigger-arg-path: direct:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt+interceding-token ngrams: unclear , howevert#interceding-token ngrams: subset oft'e1: args2Role-mention-ngram: direct thet,interceding-token ngrams: substrates or botht'interceding-token ngrams: PAK dependenttDe2: trigger-arg-path: complex:Binding nn [lemma='akt'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj Gene_or_gene_productt'interceding-token ngrams: however , howt@e1: trigger-arg-path: direct >dobj >prep_of Gene_or_gene_productt interceding-token ngrams: subsett+e1: args2Role-mention-ngram: specificity oft!interceding-token ngrams: or botht(e1: ents2Label-mention-ngram: direct thet+interceding-token ngrams: its substrates ortTe1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >nsubj controllert?interceding-tokens-full-span: or limit its accessibility towards a subset of its substrates or both . It remains unclear , however , how the PAK dependentt*e1: ents2Label-mention-ngram: might directtie1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: a subsettinterceding-token ngrams: howtKe1: trigger-arg-path: direct >dobj >prep_of controlled:Gene_or_gene_productt'interceding-token ngrams: subset of itstVe1: trigger-arg-path: lemmatizedTrigger=direct >nsubj [lemma='scaffolding'] controllertte1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >nsubj [lemma='scaffolding'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >nsubj Gene_or_gene_producttZe1: trigger-arg-path: direct >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlledt$interceding-token ngrams: substratestUe1: trigger-arg-path: lemmatizedTrigger=direct >nsubj controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: direct the substratet\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='akt'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: specificityt*e1: args2Role-mention-ngram: the substratet1CSSPATH: ROOT >ccomp ++ ROOT >acomp >ccomp >nsubjtDe2: trigger-arg-path: complex >nn [lemma='akt'] Gene_or_gene_productt%interceding-token ngrams: a subset oft&e1: args2Role-mention-ngram: substratetge1: trigger-arg-path: Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] controlledtJe2: trigger-arg-path: Binding >nn [lemma='akt'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: substrate specificityt1interceding-token ngrams: limit its accessibilitytQe2: trigger-arg-path: complex nn [lemma='akt'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nsubj [lemma='scaffolding'] Gene_or_gene_producttBe1: trigger-arg-path: direct:Positive_activation >nsubj controllertje1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >nsubj [lemma='scaffolding'] controllert'interceding-token ngrams: accessibilitytce2: trigger-arg-path: lemmatizedTrigger=complex dobj >prep_of controlledtTe1: trigger-arg-path: direct:Positive_activation >dobj >prep_of Gene_or_gene_productt$interceding-token ngrams: It remainst8e1: trigger-arg-path: direct >nsubj Gene_or_gene_productt'e1: ents2Label-mention-ngram: substratet?e1: trigger-arg-path: lemmatizedTrigger=direct:Positive_activation >dobj [lemma='specificity'] >prep_of [lemma='akt'] Gene_or_gene_productt2e1: args2Role-mention-ngram: substrate specificitytDe2: trigger-arg-path: Binding >nn [lemma='akt'] Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT might directtbe1: trigger-arg-path: direct:Positive_activation >nsubj [lemma='scaffolding'] Gene_or_gene_producttinterceding-token ngrams: -389t"interceding-token ngrams: and -389t&interceding-token ngrams: E-Box motifstte2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: directly regulate:Positive_activation nsubj [lemma='mycn'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlled:Gene_or_gene_productt&interceding-token ngrams: has recentlytme2: trigger-arg-path: directly regulate nsubj [lemma='mycn'] Gene_or_gene_productt'interceding-token ngrams: recently beenthe2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj controller:Gene_or_gene_productt%interceding-token ngrams: genes , andt#interceding-token ngrams: ) mappingt)interceding-token ngrams: transcription (t"interceding-token ngrams: CACGCG )tge2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj controllert3interceding-token ngrams: the transcriptional starttSe2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj controllertTe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mycn'] themet"interceding-token ngrams: known tot$interceding-token ngrams: within thet?e2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj [lemma='mycn'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj >nn controlledt interceding-token ngrams: motifst(interceding-token ngrams: MYCN are knownt?e2: trigger-arg-path: directly regulate:Positive_activation nsubj [lemma='mycn'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: directly regulate SHAREDtAe2: trigger-arg-path: directly regulate nsubj controllertce1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mycn'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] controlledt&interceding-token ngrams: However , ast?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlledt$interceding-token ngrams: and CACGCGtoe2: trigger-arg-path: Positive_activation nsubj [lemma='mycn'] Gene_or_gene_productt.e2: args2Role-mention-ngram: directly regulatet+interceding-token ngrams: share some commont&interceding-token ngrams: and CACGCG )tDe2: trigger-arg-path: directly regulate dobj >nn controlledt,interceding-token ngrams: some common targett1interceding-token ngrams: therefore possible thatt0e2: args2Role-mention-ngram: CONTROLLER may alsot(interceding-token ngrams: bp upstream oft(interceding-token ngrams: target genes ,t_e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='skp2'] theme:Gene_or_gene_producttxe2: trigger-arg-path: directly regulate nsubj [lemma='mycn'] controller:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='skp2'] theme:Gene_or_gene_producttinterceding-token ngrams: SKP2tIe1: trigger-arg-path: target >prep_of [lemma='mycn'] Gene_or_gene_productt"interceding-token ngrams: to sharet$interceding-token ngrams: CATGCG andtGe1: trigger-arg-path: target >nsubj [lemma='skp2'] Gene_or_gene_productt%interceding-token ngrams: bind to twotke2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj >nn controlled:Gene_or_gene_productt#interceding-token ngrams: However ,t"interceding-token ngrams: MYCN aret{e2: trigger-arg-path: directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] controlledtJe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='skp2'] themet interceding-token ngrams: CACGCGtKe2: trigger-arg-path: directly regulate nsubj Gene_or_gene_productt&interceding-token ngrams: promoter andt?e2: trigger-arg-path: directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] Gene_or_gene_productt4interceding-token ngrams: transcriptional start sitet%interceding-token ngrams: . However ,t/interceding-token ngrams: is therefore possiblet&interceding-token ngrams: and MYCN aret"interceding-token ngrams: recentlyt2interceding-token ngrams: transcription ( Bretonest'interceding-token ngrams: ( Bretones ett"interceding-token ngrams: ( CATGCGt!interceding-token ngrams: genes ,t'interceding-token ngrams: remains to betRe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='skp2'] themet?e2: trigger-arg-path: Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] Gene_or_gene_productt"interceding-token ngrams: BretonestBe1: trigger-arg-path: target:Binding >prep_of [lemma='mycn'] themetce2: trigger-arg-path: directly regulate nsubj [lemma='mycn'] controllert.interceding-token ngrams: determined . Howevert!interceding-token ngrams: to -756t+interceding-token ngrams: has recently beent,interceding-token ngrams: c-MYC has recentlyt*interceding-token ngrams: to be determinedt$interceding-token ngrams: , as c-MYCt'interceding-token ngrams: and c-MYC hast'interceding-token ngrams: be determinedt-interceding-token ngrams: recently been shownt)interceding-token ngrams: mapping to -756tWe1: trigger-arg-path: target:Binding >prep_of [lemma='mycn'] theme:Gene_or_gene_producttinterceding-token ngrams: , ) ,tMe1: trigger-arg-path: target >nsubj [lemma='skp2'] theme:Gene_or_gene_productt?interceding-tokens-full-span: remains to be determined . However , as c-MYC and MYCN are known to share some common target genes , and c-MYC has recently been shown to directly bind to two high affinity E-Box motifs ( CATGCG and CACGCG ) mapping to -756 and -389 bp upstream of the transcriptional start site within the SKP2 promoter and drive transcription ( Bretones et al. , ) , it is therefore possible thatt#CSSPATH: ROOT >csubj ++ ROOT >ccompt+interceding-token ngrams: start site withint/interceding-token ngrams: transcriptional startt@e1: trigger-arg-path: target:Binding >nsubj [lemma='skp2'] themetje2: trigger-arg-path: directly regulate:Positive_activation nsubj controller:Gene_or_gene_producttinterceding-token ngrams: drivet interceding-token ngrams: withint%interceding-token ngrams: upstream oft#interceding-token ngrams: . Howevert)interceding-token ngrams: Bretones et al.t4e2: ents2Label-mention-ngram: also directly regulatet)interceding-token ngrams: upstream of thet?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj [lemma='mycn'] controllert%interceding-token ngrams: to two hightVe2: trigger-arg-path: directly regulate nsubj controller:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_of [lemma='mycn'] Gene_or_gene_productt?e2: trigger-arg-path: directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] Gene_or_gene_productt?e2: trigger-arg-path: directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlled:Gene_or_gene_productt)interceding-token ngrams: be determined .t interceding-token ngrams: to twot;e1: trigger-arg-path: Binding >prep_of [lemma='mycn'] themet}e2: trigger-arg-path: Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlledt%interceding-token ngrams: Bretones ett#interceding-token ngrams: c-MYC andt%interceding-token ngrams: to directlyt&interceding-token ngrams: ( CATGCG andtbe2: trigger-arg-path: directly regulate:Positive_activation dobj >nn Gene_or_gene_productt0e2: args2Role-mention-ngram: regulate CONTROLLEDt interceding-token ngrams: CATGCGt!interceding-token ngrams: -389 bpt/interceding-token ngrams: drive transcription (t+interceding-token ngrams: SKP2 promoter andt:e1: trigger-arg-path: target >prep_of [lemma='mycn'] themetUe1: trigger-arg-path: target:Binding >nsubj [lemma='skp2'] theme:Gene_or_gene_productt0interceding-token ngrams: of the transcriptionalt/e2: ents2Label-mention-ngram: directly regulatetwe2: trigger-arg-path: directly regulate:Positive_activation nsubj [lemma='mycn'] controllertHe1: trigger-arg-path: Binding >nsubj [lemma='skp2'] Gene_or_gene_productt-interceding-token ngrams: drive transcriptiontue2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj [lemma='mycn'] controllertinterceding-token ngrams: sitetqe2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj Gene_or_gene_productt"interceding-token ngrams: as c-MYCtinterceding-token ngrams: c-MYCtinterceding-token ngrams: startt?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] controlled:Gene_or_gene_productt$interceding-token ngrams: remains totinterceding-token ngrams: E-Boxt[e1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mycn'] Gene_or_gene_productt9e2: args2Role-mention-ngram: directly regulate CONTROLLEDt)interceding-token ngrams: within the SKP2te2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj >nn controlled:Gene_or_gene_productt)e1: ents2Label-mention-ngram: is a directt+interceding-token ngrams: the SKP2 promotert)interceding-token ngrams: motifs ( CATGCGt'interceding-token ngrams: SKP2 promotert`e2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj >nn Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='skp2'] Gene_or_gene_productt&interceding-token ngrams: ) mapping tot%interceding-token ngrams: , and c-MYCt'interceding-token ngrams: -756 and -389t"interceding-token ngrams: the SKP2tVe2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj >nn controlledt interceding-token ngrams: ) , ittinterceding-token ngrams: sharet$interceding-token ngrams: ( BretonestUe2: trigger-arg-path: directly regulate:Positive_activation nsubj controllert%e2: args2Role-mention-ngram: regulatetOe1: trigger-arg-path: target:Binding >nsubj [lemma='skp2'] Gene_or_gene_productt(interceding-token ngrams: c-MYC and MYCNte2: trigger: directly regulatet#interceding-token ngrams: and drivet%interceding-token ngrams: to -756 andtQe1: trigger-arg-path: target:Binding >prep_of [lemma='mycn'] Gene_or_gene_productt'interceding-token ngrams: high affinityt,interceding-token ngrams: therefore possiblet_e2: trigger-arg-path: directly regulate:Positive_activation nsubj Gene_or_gene_productt"interceding-token ngrams: two hightXe2: trigger-arg-path: Positive_activation nsubj controller:Gene_or_gene_productt*interceding-token ngrams: directly bind tot[e2: trigger-arg-path: Positive_activation dobj >nn controlled:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mycn'] themet?e2: trigger-arg-path: lemmatizedTrigger=directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] controlled:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj [lemma='mycn'] Gene_or_gene_productt%interceding-token ngrams: bp upstreamt'interceding-token ngrams: to share sometOe1: trigger-arg-path: target >prep_of [lemma='mycn'] theme:Gene_or_gene_productt"interceding-token ngrams: possiblet]e2: trigger-arg-path: lemmatizedTrigger=directly regulate nsubj Gene_or_gene_productt+e2: args2Role-mention-ngram: CONTROLLER mayt$interceding-token ngrams: mapping tot8e1: trigger-arg-path: target >nsubj [lemma='skp2'] themet-interceding-token ngrams: common target genestinterceding-token ngrams: -756t9e1: trigger-arg-path: Binding >nsubj [lemma='skp2'] themet(interceding-token ngrams: affinity E-Boxt)interceding-token ngrams: site within thet$interceding-token ngrams: start sitetYe2: trigger-arg-path: directly regulate dobj >nn controlled:Gene_or_gene_productt%interceding-token ngrams: site withint&interceding-token ngrams: as c-MYC andt*interceding-token ngrams: to directly bindt#interceding-token ngrams: and c-MYCt)interceding-token ngrams: it is thereforetMe2: trigger-arg-path: Positive_activation nsubj Gene_or_gene_productt'interceding-token ngrams: directly bindt+interceding-token ngrams: shown to directlyt!interceding-token ngrams: mappingt1interceding-token ngrams: and drive transcriptiont+interceding-token ngrams: two high affinityt%interceding-token ngrams: and -389 bpt?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj [lemma='mycn'] Gene_or_gene_productt'interceding-token ngrams: possible thattXe2: trigger-arg-path: directly regulate:Positive_activation dobj >nn controlledtze2: trigger-arg-path: Positive_activation nsubj [lemma='mycn'] controller:Gene_or_gene_productt#interceding-token ngrams: are knowntae1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='skp2'] Gene_or_gene_productt"interceding-token ngrams: -756 andt&e2: ents2Label-mention-ngram: regulatet*interceding-token ngrams: -389 bp upstreamt&interceding-token ngrams: are known tot'interceding-token ngrams: common targettPe2: trigger-arg-path: Positive_activation dobj >nn Gene_or_gene_productt(interceding-token ngrams: E-Box motifs (tee2: trigger-arg-path: Positive_activation nsubj [lemma='mycn'] controllert-interceding-token ngrams: high affinity E-Boxt(e1: args2Role-mention-ngram: is a directt?e2: trigger-arg-path: directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] Gene_or_gene_productt interceding-token ngrams: commontNe1: trigger-arg-path: Binding >nsubj [lemma='skp2'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='mycn'] theme:Gene_or_gene_producttme2: trigger-arg-path: directly regulate:Positive_activation dobj >nn controlled:Gene_or_gene_productt"interceding-token ngrams: motifs (t?e2: trigger-arg-path: directly regulate dobj [lemma='expression'] >nn [lemma='skp2'] controlled:Gene_or_gene_productt!interceding-token ngrams: HowevertCe2: trigger-arg-path: Positive_activation nsubj controllert%interceding-token ngrams: some commontPe1: trigger-arg-path: Binding >prep_of [lemma='mycn'] theme:Gene_or_gene_productt+interceding-token ngrams: CATGCG and CACGCGtNe2: trigger-arg-path: directly regulate dobj >nn Gene_or_gene_productt/interceding-token ngrams: affinity E-Box motifst(interceding-token ngrams: known to sharet3e2: args2Role-mention-ngram: also directly regulatet?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation dobj [lemma='expression'] >nn [lemma='skp2'] Gene_or_gene_producttinterceding-token ngrams: MYCNt"interceding-token ngrams: and MYCNt#interceding-token ngrams: c-MYC hast,interceding-token ngrams: promoter and drivet*interceding-token ngrams: CACGCG ) mappingt$interceding-token ngrams: share somet?e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj [lemma='mycn'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='mycn'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: regulate SHAREDt|e2: trigger-arg-path: lemmatizedTrigger=directly regulate:Positive_activation nsubj controller:Gene_or_gene_productt&interceding-token ngrams: is thereforet]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='cdk4'] Gene_or_gene_producttYe1: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] Familyt>e2: trigger-arg-path: complex:Binding >nn [lemma='cdk4'] themetHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] themet6e2: trigger-arg-path: Binding >nn [lemma='cdk4'] themetGe1: trigger-arg-path: complexes >nn [lemma='cdk4'] Gene_or_gene_productt3interceding-tokens-full-span: . In this sense , thet8e2: trigger-arg-path: complex nn theme:Familyt$interceding-token ngrams: this senset1e2: trigger-arg-path: Binding nn themetge2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] theme:Familyt'interceding-token ngrams: In this senset8e2: trigger-arg-path: Binding nn theme:Familyt@e1: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] themetKe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn themet`e2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] themet!interceding-token ngrams: sense ,tNe1: trigger-arg-path: Binding nn [lemma='cyclin'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] themetDe2: trigger-arg-path: lemmatizedTrigger=complex nn FamilytOe1: trigger-arg-path: Binding nn [lemma='cyclin'] Familytinterceding-token ngrams: sensetPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] themetge1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] theme:Familyt_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] Gene_or_gene_producttUe1: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] FamilytKe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn themet&interceding-token ngrams: this sense ,t#interceding-token ngrams: . In thistOe2: trigger-arg-path: Binding nn [lemma='cyclin'] Familythe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] themet2e2: trigger-arg-path: complex nn Familyt6e2: trigger-arg-path: complex >nn [lemma='cdk4'] themet3e1: trigger-arg-path: complexes nn themetWe1: trigger-arg-path: complexes nn [lemma='cyclin'] theme:FamilytNe2: trigger-arg-path: Binding nn [lemma='cyclin'] themetWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] Gene_or_gene_productt1e2: trigger-arg-path: complex nn themetae1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] Familyt2e2: trigger-arg-path: Binding nn Familyt8e1: trigger-arg-path: complexes >nn [lemma='cdk4'] themetEe1: trigger-arg-path: Binding >nn [lemma='cdk4'] Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='cdk4'] theme:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='cdk4'] theme:Gene_or_gene_productt%interceding-token ngrams: sense , thetMe2: trigger-arg-path: complex:Binding >nn [lemma='cdk4'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] Familythe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] themetOe2: trigger-arg-path: complex nn [lemma='cyclin'] FamilytNe2: trigger-arg-path: complex nn [lemma='cyclin'] themetCe1: trigger-arg-path: lemmatizedTrigger=complex nn themetLe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn Familytie2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] Familytee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:Familytoe2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] theme:Familyt:CSSPATH: ROOT >nsubj >rcmod >acomp >prep_to ++ ROOT >nsubjt8e1: trigger-arg-path: Binding nn theme:FamilytQe1: trigger-arg-path: complexes nn [lemma='cyclin'] FamilytXe1: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] themetLe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn Familytoe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] theme:FamilytKe1: trigger-arg-path: Binding >nn [lemma='cdk4'] theme:Gene_or_gene_productt9e2: trigger-arg-path: complex:Binding nn themetUe2: trigger-arg-path: complex nn [lemma='cyclin'] theme:Familyt`e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] themet2e1: trigger-arg-path: Binding nn FamilytOe1: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='cdk4'] theme:Gene_or_gene_producttVe2: trigger-arg-path: complex:Binding nn [lemma='cyclin'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] themet:e1: trigger-arg-path: complexes nn theme:Familyt_e1: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] theme:FamilytBe1: trigger-arg-path: complexes:Binding nn theme:Familyt6e1: trigger-arg-path: Binding >nn [lemma='cdk4'] themet!interceding-token ngrams: In thistUe1: trigger-arg-path: Binding nn [lemma='cyclin'] theme:FamilytCe2: trigger-arg-path: lemmatizedTrigger=complex nn themetMe1: trigger-arg-path: complexes >nn [lemma='cdk4'] theme:Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='cdk4'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=complex nn theme:Familyt1e1: trigger-arg-path: Binding nn themet_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk4'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn theme:Familyt@e2: trigger-arg-path: complex:Binding nn theme:Familyt:e2: trigger-arg-path: complex:Binding nn Familyt;e1: trigger-arg-path: complexes:Binding nn themet]e2: trigger-arg-path: complex:Binding nn [lemma='cyclin'] theme:FamilytDe1: trigger-arg-path: lemmatizedTrigger=complex nn FamilytWe2: trigger-arg-path: complex:Binding nn [lemma='cyclin'] FamilytJe1: trigger-arg-path: lemmatizedTrigger=complex nn theme:Familytee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk4'] theme:Gene_or_gene_productt4e1: trigger-arg-path: complexes nn FamilytPe1: trigger-arg-path: complexes nn [lemma='cyclin'] themetnn FamilytUe2: trigger-arg-path: Binding nn [lemma='cyclin'] theme:FamilytDe2: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] themetFe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] themet5e2: trigger-arg-path: complex >nn [lemma='ra'] FamilytNe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] themet7e1: ents2Label-mention-ngram: of nucleotide-free SHAREDtKe2: trigger-arg-path: complex >nn [lemma='pi3kc2beta'] Gene_or_gene_productt6e2: trigger-arg-path: complex:Binding >nn theme:Familytee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] themet7e1: ents2Label-mention-ngram: nucleotide-free SHARED totQe2: trigger-arg-path: Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttCe2: trigger-arg-path: complex:Binding >nn [lemma='ra'] theme:FamilytSe2: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] themet(e2: trigger-arg-path: complex >nn FamilytKe2: trigger-arg-path: Binding >nn [lemma='pi3kc2beta'] Gene_or_gene_productt:e2: trigger-arg-path: lemmatizedTrigger=complex >nn FamilytFinterceding-tokens-full-span: inhibits its lipid kinase activity . ThetBe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn FamilytUe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] theme:Familyt=e2: trigger-arg-path: complex:Binding >nn [lemma='ra'] Familytke2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn theme:FamilytOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ra'] Familyt4e2: trigger-arg-path: complex >nn [lemma='ra'] themet;e2: trigger-arg-path: complex >nn [lemma='ra'] theme:FamilytQe2: trigger-arg-path: complex >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_producttnn [lemma='pi3kc2beta'] themetce2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_productt0e2: trigger-arg-path: complex:Binding >nn FamilytMe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] theme:Familyt@e2: trigger-arg-path: lemmatizedTrigger=complex >nn theme:Familyt.e2: trigger-arg-path: complex >nn theme:Familyt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='pi3kc2beta'] Gene_or_gene_producttnn [lemma='ra'] themetnn [lemma='pi3kc2beta'] themetGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ra'] FamilytYe2: trigger-arg-path: complex:Binding >nn [lemma='pi3kc2beta'] theme:Gene_or_gene_productt'interceding-token ngrams: Kamura et al.t'interceding-token ngrams: mediate theirt interceding-token ngrams: IRS1 ,tinterceding-token ngrams: JAK2t$interceding-token ngrams: Vav , IRS1t,interceding-token ngrams: likely because thetinterceding-token ngrams: , ;tOe1: trigger-arg-path: Binding >prep_between [lemma='cul5'] Gene_or_gene_productt%interceding-token ngrams: Since SOCS1tRe2: trigger-arg-path: binds:Binding >prep_to [lemma='module'] Gene_or_gene_productt'interceding-token ngrams: been detectedt interceding-token ngrams: , IRS1t0interceding-token ngrams: actually mediate theirt interceding-token ngrams: Rui ettte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='socs1'] theme:Gene_or_gene_productt interceding-token ngrams: likelytSe1: trigger-arg-path: interaction >prep_between [lemma='cul5'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='cul5'] theme:Gene_or_gene_productt'interceding-token ngrams: ; Kamizono ett$interceding-token ngrams: SOCS1 withtee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cul5'] Gene_or_gene_productt&interceding-token ngrams: , ; Kamizonot#interceding-token ngrams: SepulvedatEe1: trigger-arg-path: interaction >prep_between [lemma='socs1'] themet2interceding-token ngrams: polyubiquitinates JAK2 ,tce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='module'] Gene_or_gene_productt1interceding-token ngrams: SOCS1 polyubiquitinatestinterceding-token ngrams: Det-interceding-token ngrams: box is incompletelyt*interceding-token ngrams: because the Cul5tPe1: trigger-arg-path: Binding >prep_between [lemma='socs1'] Gene_or_gene_productt'interceding-token ngrams: . Since SOCS1t&interceding-token ngrams: the Cul5 boxt-interceding-token ngrams: most likely becausetZe1: trigger-arg-path: interaction >prep_between [lemma='socs1'] theme:Gene_or_gene_productt*interceding-token ngrams: degradation , ort0interceding-token ngrams: polyubiquitinates JAK2tinterceding-token ngrams: VavtVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cul5'] themetWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='socs1'] themetae2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='module'] theme:Gene_or_gene_productt6interceding-token ngrams: SOCS1 polyubiquitinates JAK2t=e2: trigger-arg-path: Binding >prep_to [lemma='module'] themet^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cul5'] themetinterceding-token ngrams: IRS1tMe2: trigger-arg-path: binds >nsubj [lemma='socs1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: binds:Binding >prep_to [lemma='module'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interaction >prep_between [lemma='socs1'] Gene_or_gene_productt3interceding-token ngrams: is incompletely conservedtinterceding-token ngrams: ( s )tIe2: trigger-arg-path: Binding >nsubj [lemma='socs1'] Gene_or_gene_productt"interceding-token ngrams: of SOCS1t,interceding-token ngrams: polyubiquitinationt!interceding-token ngrams: , ; Ruit%interceding-token ngrams: because thet'interceding-token ngrams: degradation ,t#interceding-token ngrams: conservedt'interceding-token ngrams: of SOCS1 withtbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='socs1'] theme:Gene_or_gene_productt"interceding-token ngrams: the Cul5t)interceding-token ngrams: other ubiquitint)interceding-token ngrams: been detected ,t$interceding-token ngrams: ; Kamizonot%interceding-token ngrams: most likelyt,interceding-token ngrams: ubiquitin ligase (tne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='socs1'] Gene_or_gene_productt&interceding-token ngrams: De Sepulvedat0interceding-token ngrams: other ubiquitin ligaset interceding-token ngrams: Kamurat"interceding-token ngrams: ; Rui ettCe2: trigger-arg-path: binds:Binding >prep_to [lemma='module'] themet+interceding-token ngrams: has been detectedt$interceding-token ngrams: JAK2 , Vavt*interceding-token ngrams: actually mediatet2CSSPATH: ROOT >nsubjpass ++ ROOT >ccomp >dobj >dept3interceding-token ngrams: these substrates recruitst*interceding-token ngrams: SOCS1 with theset-interceding-token ngrams: substrates recruitstOe2: trigger-arg-path: binds:Binding >nsubj [lemma='socs1'] Gene_or_gene_productt!interceding-token ngrams: al. , ;tXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='socs1'] Gene_or_gene_productt.interceding-token ngrams: interaction of SOCS1t interceding-token ngrams: JAK2 ,t$interceding-token ngrams: IRS1 , andt"interceding-token ngrams: s ) thattinterceding-token ngrams: Vav ,tLe2: trigger-arg-path: Binding >prep_to [lemma='module'] Gene_or_gene_producttae1: trigger-arg-path: interaction:Binding >prep_between [lemma='cul5'] theme:Gene_or_gene_producttinterceding-token ngrams: , Vavt8e2: trigger-arg-path: binds >nsubj [lemma='socs1'] themet+interceding-token ngrams: polyubiquitinatestOe2: trigger-arg-path: Binding >nsubj [lemma='socs1'] theme:Gene_or_gene_productt!interceding-token ngrams: . Sincet"interceding-token ngrams: actuallytAe1: trigger-arg-path: Binding >prep_between [lemma='socs1'] themet/interceding-token ngrams: that actually mediatet)interceding-token ngrams: detected , mostt+interceding-token ngrams: possible that thet$interceding-token ngrams: detected ,t\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='socs1'] Gene_or_gene_productt&interceding-token ngrams: Sepulveda ett"interceding-token ngrams: Cul5 boxtinterceding-token ngrams: st"interceding-token ngrams: ligase (t[e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='module'] Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >nsubj [lemma='socs1'] theme:Gene_or_gene_productt(interceding-token ngrams: ( De Sepulvedat'interceding-token ngrams: that actuallytinterceding-token ngrams: ( stfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='socs1'] Gene_or_gene_productt&interceding-token ngrams: incompletelyt2interceding-token ngrams: their polyubiquitinationt(interceding-token ngrams: likely becauset^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='socs1'] theme:Gene_or_gene_producttJe2: trigger-arg-path: binds >prep_to [lemma='module'] Gene_or_gene_productt)interceding-token ngrams: Kamizono et al.tYe1: trigger-arg-path: interaction >prep_between [lemma='cul5'] theme:Gene_or_gene_productt"interceding-token ngrams: , IRS1 ,t)interceding-token ngrams: is incompletelytinterceding-token ngrams: Ruit$interceding-token ngrams: Rui et al.tfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='socs1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='socs1'] themet(interceding-token ngrams: it is possiblet@e2: trigger-arg-path: binds:Binding >nsubj [lemma='socs1'] themet$interceding-token ngrams: , and IRS2t*interceding-token ngrams: is possible thatt6interceding-token ngrams: their polyubiquitination andt interceding-token ngrams: ) thatt'interceding-token ngrams: , most likelyt/interceding-token ngrams: with these substratestinterceding-token ngrams: Sincetinterceding-token ngrams: SOCS1t+interceding-token ngrams: and degradation ,tPe2: trigger-arg-path: binds >prep_to [lemma='module'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='socs1'] themet$interceding-token ngrams: ligase ( stDe1: trigger-arg-path: interaction >prep_between [lemma='cul5'] themet%interceding-token ngrams: ( Kamura ett"interceding-token ngrams: Kamizonotinterceding-token ngrams: Cul5tGe2: trigger-arg-path: binds >nsubj [lemma='socs1'] Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='cul5'] themet$interceding-token ngrams: with theset)interceding-token ngrams: De Sepulveda ett interceding-token ngrams: , mosttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='module'] theme:Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_between [lemma='socs1'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='socs1'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='socs1'] themet7interceding-token ngrams: Since SOCS1 polyubiquitinatest0interceding-token ngrams: polyubiquitination andt%interceding-token ngrams: Kamizono ett.interceding-token ngrams: that the interactiont#interceding-token ngrams: ) . Sincet!interceding-token ngrams: becauset!interceding-token ngrams: or thatt*interceding-token ngrams: Sepulveda et al.t%interceding-token ngrams: is possibletme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cul5'] Gene_or_gene_productt(interceding-token ngrams: recruits othert2interceding-token ngrams: incompletely conserved (tMe1: trigger-arg-path: interaction:Binding >prep_between [lemma='socs1'] themet!interceding-token ngrams: , Vav ,t[e1: trigger-arg-path: interaction:Binding >prep_between [lemma='cul5'] Gene_or_gene_producttLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='cul5'] themet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='socs1'] Gene_or_gene_productt"interceding-token ngrams: and IRS2tinterceding-token ngrams: IRS2t,interceding-token ngrams: conserved ( Kamuratprep_to [lemma='module'] themet$interceding-token ngrams: and IRS2 (t%interceding-token ngrams: conserved (t:e2: trigger-arg-path: Binding >nsubj [lemma='socs1'] themet?interceding-tokens-full-span: has been detected , most likely because the Cul5 box is incompletely conserved ( Kamura et al. , ) . Since SOCS1 polyubiquitinates JAK2 , Vav , IRS1 , and IRS2 ( De Sepulveda et al. , ; Kamizono et al. , ; Rui et al. , ) , it is possible that the interaction of SOCS1 with these substrates recruits other ubiquitin ligase ( s ) that actually mediate their polyubiquitination and degradation , or thatt)interceding-token ngrams: ) that actuallyt"interceding-token ngrams: ( KamuratRe2: trigger-arg-path: Binding >prep_to [lemma='module'] theme:Gene_or_gene_productt0interceding-token ngrams: incompletely conservedtinterceding-token ngrams: mosttinterceding-token ngrams: ; Ruit3interceding-token ngrams: substrates recruits othert#interceding-token ngrams: , or thatt interceding-token ngrams: IRS2 (t*interceding-token ngrams: these substratestinterceding-token ngrams: ( Det2interceding-token ngrams: recruits other ubiquitint;e2: trigger-arg-path: binds >prep_to [lemma='module'] themetse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cul5'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='module'] themetke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cul5'] theme:Gene_or_gene_productt#interceding-token ngrams: IRS2 ( Det0e2: ents2Label-mention-ngram: with growth factort#e2: args2Role-mention-ngram: Factort7e2: ents2Label-mention-ngram: increases phosphorylationt4e2: args2Role-mention-ngram: Epidermal Growth FactortCe1: trigger-arg-path: interaction >prep_between [lemma='pml'] themet_e2: trigger-arg-path: increases >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controllert#e2: ents2Label-mention-ngram: EGF )t~e2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controllertNe2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of controllert^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pin1'] themet%e2: args2Role-mention-ngram: Factor (tVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pin1'] themet%e2: ents2Label-mention-ngram: such ast-e2: ents2Label-mention-ngram: EGF ) increasest#e2: args2Role-mention-ngram: Growthtte2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: Epidermalt!e2: ents2Label-mention-ngram: PMLt`e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: with growth factort1e2: ents2Label-mention-ngram: as Epidermal Growtht*e2: ents2Label-mention-ngram: Factor ( EGFt`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='pml'] theme:Gene_or_gene_productt)interceding-token ngrams: upregulation oft-interceding-token ngrams: upregulation of PMLt7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT witht_e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of controllertme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pin1'] Gene_or_gene_productt)e2: args2Role-mention-ngram: as Epidermalt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT with growtht[e1: trigger-arg-path: interaction:Binding >prep_between [lemma='pin1'] Gene_or_gene_productt?e1: trigger-arg-path: Binding >prep_between [lemma='pml'] themetze2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pin1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: Growth Factortse2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] Gene_or_gene_productt,e2: args2Role-mention-ngram: EGF ) increasestre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pml'] theme:Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_between [lemma='pml'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: Epidermal Growtht9e2: ents2Label-mention-ngram: ) increases phosphorylationt,e2: ents2Label-mention-ngram: factor such ast&e2: args2Role-mention-ngram: Epidermaltie2: trigger-arg-path: increases >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: Factor (t]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pml'] themet+e2: args2Role-mention-ngram: factor such astle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pml'] Gene_or_gene_productt0interceding-token ngrams: formation . Converselyt?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: ( EGF )tOe1: trigger-arg-path: Binding >prep_between [lemma='pin1'] Gene_or_gene_producttae1: trigger-arg-path: interaction:Binding >prep_between [lemma='pin1'] theme:Gene_or_gene_productt!interceding-token ngrams: PML-NBstOe2: trigger-arg-path: increases >nsubj >prep_of controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: ) increasestRe1: trigger-arg-path: interaction >prep_between [lemma='pml'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: Growth FactortXe1: trigger-arg-path: interaction >prep_between [lemma='pml'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interaction >prep_between [lemma='pin1'] Gene_or_gene_productt!e2: args2Role-mention-ngram: sucht4e2: ents2Label-mention-ngram: phosphorylation of PMLtYe1: trigger-arg-path: interaction >prep_between [lemma='pin1'] theme:Gene_or_gene_productt5e2: ents2Label-mention-ngram: Epidermal Growth Factort+interceding-token ngrams: PML-NBs formationt0e2: args2Role-mention-ngram: as Epidermal Growtht:e2: ents2Label-mention-ngram: increases phosphorylation oft(e2: ents2Label-mention-ngram: of PML andtNe1: trigger-arg-path: Binding >prep_between [lemma='pml'] Gene_or_gene_productt"e2: args2Role-mention-ngram: ( EGFt$e2: args2Role-mention-ngram: such ast'interceding-token ngrams: , stimulationtUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pml'] themet#e2: ents2Label-mention-ngram: ( EGFt e2: ents2Label-mention-ngram: ast-e2: ents2Label-mention-ngram: Growth Factor (t.e2: args2Role-mention-ngram: such as Epidermaltrinterceding-tokens-full-span: , leading to upregulation of PML and PML-NBs formation . Conversely , stimulation oft$e2: args2Role-mention-ngram: ( EGF )t0e2: ents2Label-mention-ngram: and GENERIC_ENTITYt!interceding-token ngrams: PML andt)e2: args2Role-mention-ngram: Factor ( EGFtUe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of Gene_or_gene_productt,e2: args2Role-mention-ngram: Growth Factor (t@e1: trigger-arg-path: Binding >prep_between [lemma='pin1'] themet%interceding-token ngrams: and PML-NBst)e2: ents2Label-mention-ngram: with growtht1interceding-token ngrams: leading to upregulationtte2: trigger-arg-path: increases >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controller:Gene_or_gene_producttDe1: trigger-arg-path: interaction >prep_between [lemma='pin1'] themet-e2: args2Role-mention-ngram: Epidermal Growthtpe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controllert(e2: args2Role-mention-ngram: ) increasestDe2: trigger-arg-path: increases >nsubj >prep_of Gene_or_gene_productt,interceding-token ngrams: to upregulation oft3e2: args2Role-mention-ngram: CONTROLLER with growthte2: args2Role-mention-ngram: ast*interceding-token ngrams: , stimulation oft2interceding-token ngrams: Conversely , stimulationtie2: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controllertKe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of controllert?e2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: such as Epidermalt/e2: args2Role-mention-ngram: growth factor suchtLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='pin1'] themet*e2: args2Role-mention-ngram: growth factortke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pin1'] theme:Gene_or_gene_productt-interceding-token ngrams: PML-NBs formation .t$e2: ents2Label-mention-ngram: Factortse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pin1'] theme:Gene_or_gene_producttZe1: trigger-arg-path: interaction:Binding >prep_between [lemma='pml'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pml'] Gene_or_gene_productt:e2: trigger-arg-path: increases >nsubj >prep_of controllert$interceding-token ngrams: of PML andt$e2: ents2Label-mention-ngram: Growthtie2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of Gene_or_gene_producttKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='pml'] themet0e2: ents2Label-mention-ngram: growth factor suchtse2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controllert}e2: trigger-arg-path: increases:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] Gene_or_gene_productt)interceding-token ngrams: to upregulationt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='pin1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt(e2: args2Role-mention-ngram: with growtht3e2: args2Role-mention-ngram: ) increases CONTROLLEDtXe2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of Gene_or_gene_productt%interceding-token ngrams: formation .t)e2: ents2Label-mention-ngram: factor sucht*e2: ents2Label-mention-ngram: as Epidermalt"e2: ents2Label-mention-ngram: sucht4e2: ents2Label-mention-ngram: PML and GENERIC_ENTITYt%e2: ents2Label-mention-ngram: PML andt+e2: ents2Label-mention-ngram: growth factortje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pml'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: EGF )t/interceding-token ngrams: and PML-NBs formationt$e2: ents2Label-mention-ngram: of PMLt)interceding-token ngrams: PML and PML-NBstce2: trigger-arg-path: increases:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt(e2: args2Role-mention-ngram: factor sucht;shortest-path: advmod [lemma='also']t%e2: ents2Label-mention-ngram: controlt-e1: args2Role-mention-ngram: control proteinst(e2: args2Role-mention-ngram: to the cellt)e1: ents2Label-mention-ngram: to the cellt%e2: args2Role-mention-ngram: the cellt/e1: ents2Label-mention-ngram: SHARED also bindst+e1: ents2Label-mention-ngram: cycle controltMe1: trigger-arg-path: binds >prep_to [lemma='p14'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: the cell cyclet-e2: args2Role-mention-ngram: THEME also bindst/e1: args2Role-mention-ngram: cell cycle controlt%e1: ents2Label-mention-ngram: controlt$e1: args2Role-mention-ngram: controlt'e2: args2Role-mention-ngram: also bindstIe2: trigger-arg-path: Binding >prep_to [lemma='p14'] Gene_or_gene_productt$e2: args2Role-mention-ngram: controlt4e2: ents2Label-mention-ngram: cycle control proteinst+e2: args2Role-mention-ngram: proteins THEMEt(e1: args2Role-mention-ngram: to the celltMe2: trigger-arg-path: binds >prep_to [lemma='p14'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: cell cycle controltOe1: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: control proteinstUe1: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: the celltXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] Gene_or_gene_producttOe2: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] themet/e2: ents2Label-mention-ngram: SHARED also bindst*e2: args2Role-mention-ngram: also binds tot&e2: ents2Label-mention-ngram: the celltGe1: trigger-arg-path: binds >prep_to [lemma='p14'] Gene_or_gene_productt8e2: trigger-arg-path: binds >prep_to [lemma='p14'] themet'e2: args2Role-mention-ngram: cell cyclet&e1: ents2Label-mention-ngram: the celltUe2: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] themet#e1: ents2Label-mention-ngram: cyclet-e2: ents2Label-mention-ngram: proteins SHAREDt"e1: args2Role-mention-ngram: cyclet,e1: ents2Label-mention-ngram: the cell cyclet0e2: ents2Label-mention-ngram: cell cycle controlt3e1: args2Role-mention-ngram: cycle control proteinst@e2: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] themetOe2: trigger-arg-path: Binding >prep_to [lemma='p14'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: also binds tot+e1: args2Role-mention-ngram: proteins THEMEt*e1: args2Role-mention-ngram: cycle controlt(e2: ents2Label-mention-ngram: cell cyclet5e1: ents2Label-mention-ngram: control proteins SHAREDt/e2: args2Role-mention-ngram: cell cycle controlt*e2: args2Role-mention-ngram: cycle controlt3e1: args2Role-mention-ngram: control proteins THEMEt4e1: ents2Label-mention-ngram: cycle control proteinst@e1: trigger-arg-path: binds:Binding >prep_to [lemma='p14'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p14'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: cycletGe2: trigger-arg-path: binds >prep_to [lemma='p14'] Gene_or_gene_productt-e2: args2Role-mention-ngram: control proteinst#e2: ents2Label-mention-ngram: cyclet.e1: ents2Label-mention-ngram: control proteinst3e2: args2Role-mention-ngram: cycle control proteinst'e1: args2Role-mention-ngram: cell cyclet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p14'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: to the cellt-e1: ents2Label-mention-ngram: proteins SHAREDt,e2: ents2Label-mention-ngram: the cell cyclet:e2: trigger-arg-path: Binding >prep_to [lemma='p14'] themet5e2: ents2Label-mention-ngram: control proteins SHAREDt(e1: ents2Label-mention-ngram: cell cyclet3e2: args2Role-mention-ngram: control proteins THEMEt+e2: ents2Label-mention-ngram: cycle controlt+e2: args2Role-mention-ngram: the cell cyclet8e1: trigger-arg-path: binds >prep_to [lemma='p14'] themet-e1: ents2Label-mention-ngram: ternary complext&interceding-token ngrams: . The secondtOe1: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] controllert(e2: ents2Label-mention-ngram: cellularlytje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themetFe2: ents2Label-mention-ngram: cellularly abundant GENE_OR_GENE_PRODUCTt'interceding-token ngrams: in release oft'e2: args2Role-mention-ngram: cellularlyt0e1: args2Role-mention-ngram: the ternary complext interceding-token ngrams: GDP tot!interceding-token ngrams: releasetOe2: trigger-arg-path: Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttQe2: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] FamilytNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to theme:Familyt#e2: args2Role-mention-ngram: the wtt$interceding-token ngrams: The secondtIe2: trigger-arg-path: Binding >prep_of [lemma='gtp'] Gene_or_gene_productt!interceding-token ngrams: step ist]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventt2e1: ents2Label-mention-ngram: complex disrupts thet(interceding-token ngrams: produce the wtt'interceding-token ngrams: the bound GDPt/e2: ents2Label-mention-ngram: of the cellularlytDe1: trigger-arg-path: disrupts >nsubj [lemma='formation'] controllertce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] FamilytHe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to Familytie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: abundant GENE_OR_GENE_PRODUCT tot.e1: args2Role-mention-ngram: CONTROLLER of thetPe2: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themetWe2: trigger-arg-path: binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familytke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] FamilytIe1: trigger-arg-path: Negative_regulation >nsubj controller:Generic_eventtDe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj Generic_eventt6e2: trigger-arg-path: Binding >prep_of >prep_to Familyt&interceding-token ngrams: Cdc25 binaryt.e2: args2Role-mention-ngram: abundant THEME tot6e2: args2Role-mention-ngram: cellularly abundant THEMEt9e1: ents2Label-mention-ngram: binding interaction betweent4e1: ents2Label-mention-ngram: interaction between wtt>e2: trigger-arg-path: binding:Binding >prep_of >prep_to Familyt.e1: ents2Label-mention-ngram: complex disruptst interceding-token ngrams: secondtXe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] Generic_eventt0e2: args2Role-mention-ngram: cellularly abundantt+e2: ents2Label-mention-ngram: the wt SHAREDt(interceding-token ngrams: binary complext,e2: ents2Label-mention-ngram: the cellularlyt*interceding-token ngrams: binary complex .t+e2: args2Role-mention-ngram: the cellularlyt>e1: trigger-arg-path: disrupts >nsubj controller:Generic_eventt%interceding-token ngrams: second stept1e1: args2Role-mention-ngram: complex disrupts thetGe1: trigger-arg-path: disrupts:Negative_regulation >nsubj Generic_eventtQe2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: disrupts the bindingtie1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] controllertae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt(e1: ents2Label-mention-ngram: between wttRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] Generic_eventtOe2: trigger-arg-path: binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventt:e2: trigger-arg-path: binding >prep_of [lemma='gtp'] themet(interceding-token ngrams: second step ist$interceding-token ngrams: in releaset'interceding-token ngrams: complex . Thetle1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] Generic_eventt[e1: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] Generic_eventtDe2: trigger-arg-path: binding:Binding >prep_of >prep_to theme:Familyt6e1: ents2Label-mention-ngram: ternary complex disruptst)interceding-token ngrams: The second steptqe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt&interceding-token ngrams: of the boundt$interceding-token ngrams: release oft5e1: ents2Label-mention-ngram: the binding interactiont%e2: args2Role-mention-ngram: abundantt:e2: trigger-arg-path: Binding >prep_of [lemma='gtp'] themet(interceding-token ngrams: GDP to producetprep_of >prep_to theme:Familyt-e1: args2Role-mention-ngram: complex disruptst>e1: trigger-arg-path: Negative_regulation >nsubj Generic_eventtXe1: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] controllert1e1: args2Role-mention-ngram: disrupts the bindingtXe2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themet_e2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt4e2: args2Role-mention-ngram: the cellularly abundantt)e2: args2Role-mention-ngram: the wt THEMEt+e1: args2Role-mention-ngram: of the ternarytie2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt+e1: ents2Label-mention-ngram: wt SHARED andt5e1: args2Role-mention-ngram: ternary complex disruptstce1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj controller:Generic_eventt&interceding-token ngrams: bound GDP tot*interceding-token ngrams: Ras Cdc25 binarytPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to FamilytWe2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] theme:Gene_or_gene_producttinterceding-token ngrams: stept.interceding-token ngrams: Cdc25 binary complextfe1: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventtPe2: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themetce1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] controller:Generic_eventt*e1: args2Role-mention-ngram: CONTROLLER oftUe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] controllertTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='gtp'] themet,e1: args2Role-mention-ngram: ternary complext&e2: ents2Label-mention-ngram: abundantt#interceding-token ngrams: bound GDPt$e1: args2Role-mention-ngram: ternaryt)e1: ents2Label-mention-ngram: the ternaryt6e2: trigger-arg-path: binding >prep_of >prep_to Familytbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] themet(interceding-token ngrams: release of thet.interceding-token ngrams: resulting in releaset%e1: ents2Label-mention-ngram: ternarytXe1: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj Generic_eventtYe2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] Familyt1e1: ents2Label-mention-ngram: the ternary complextIe2: trigger-arg-path: binding >prep_of [lemma='gtp'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] Gene_or_gene_producttprep_of >prep_to theme:Familyt%interceding-token ngrams: step is thetVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to theme:FamilytGe1: trigger-arg-path: disrupts >nsubj [lemma='formation'] Generic_eventt%interceding-token ngrams: produce thet?interceding-tokens-full-span: , resulting in release of the bound GDP to produce the wt Ras Cdc25 binary complex . The second step is thetOe1: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj controller:Generic_eventtDe1: trigger-arg-path: disrupts:Negative_regulation >nsubj controllert3e1: args2Role-mention-ngram: the binding CONTROLLEDt5e2: ents2Label-mention-ngram: the cellularly abundanttLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='gtp'] themetRe1: trigger-arg-path: disrupts:Negative_regulation >nsubj controller:Generic_eventt3e1: trigger-arg-path: disrupts >nsubj Generic_eventt(interceding-token ngrams: to produce thet$e2: ents2Label-mention-ngram: the wttRe1: trigger-arg-path: disrupts >nsubj [lemma='formation'] controller:Generic_eventt&interceding-token ngrams: wt Ras Cdc25t'e2: ents2Label-mention-ngram: to the wtt&e2: args2Role-mention-ngram: to the wtt+e2: args2Role-mention-ngram: abundant THEMEt/e1: args2Role-mention-ngram: binding CONTROLLEDt,e1: ents2Label-mention-ngram: of the ternaryt(e1: args2Role-mention-ngram: the ternaryt;e2: ents2Label-mention-ngram: abundant GENE_OR_GENE_PRODUCTt interceding-token ngrams: binaryt/e1: ents2Label-mention-ngram: between wt SHAREDt#interceding-token ngrams: Ras Cdc25tWe2: trigger-arg-path: Binding >prep_of [lemma='gtp'] >prep_to [lemma='ra'] theme:Familyt1e2: ents2Label-mention-ngram: cellularly abundantt.e2: args2Role-mention-ngram: of the cellularlytBe2: trigger-arg-path: binding:Binding >prep_of [lemma='gtp'] themet?e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controller:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert!interceding-token ngrams: ( CIP )t2interceding-token ngrams: intestinal phosphatase (tinterceding-token ngrams: calftinterceding-token ngrams: Totie1: trigger-arg-path: phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] Gene_or_gene_productt+interceding-token ngrams: a phosphorylationt+interceding-token ngrams: phosphatase ( CIPt'interceding-token ngrams: was abolishedtxe1: trigger-arg-path: Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] Gene_or_gene_producttte1: trigger-arg-path: phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controller:Gene_or_gene_producttinterceding-token ngrams: CIPt#interceding-token ngrams: modulatest7e2: args2Role-mention-ngram: kinase directly CONTROLLEDt.CSSPATH: ROOT >nsubjpass ++ ROOT >csubj >ccompt!interceding-token ngrams: FBW7 int$interceding-token ngrams: ERK kinaset$interceding-token ngrams: . To provet3interceding-token ngrams: phosphorylation dependentt)interceding-token ngrams: calf intestinalt}e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: kinase directlytinterceding-token ngrams: CIP )tce1: trigger-arg-path: Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controllert5interceding-token ngrams: a phosphorylation dependentt&interceding-token ngrams: abolished byt)interceding-token ngrams: that ERK kinasetinterceding-token ngrams: ( CIPt%interceding-token ngrams: manner . Totne2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt'interceding-token ngrams: ) treatment ,t?interceding-tokens-full-span: was abolished by calf intestinal phosphatase ( CIP ) treatment , indicating that ERK kinase modulates FBW7 in a phosphorylation dependent manner . To prove thatt5interceding-token ngrams: calf intestinal phosphataset,e2: args2Role-mention-ngram: kinase directlyt_e1: trigger-arg-path: phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controllert.interceding-token ngrams: in a phosphorylationt0interceding-token ngrams: treatment , indicatingtinterceding-token ngrams: provet)interceding-token ngrams: CIP ) treatmentt$interceding-token ngrams: prove thatt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controllertce2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt(interceding-token ngrams: modulates FBW7tse1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controllert*interceding-token ngrams: kinase modulatest%interceding-token ngrams: ) treatmentt#interceding-token ngrams: FBW7 in atinterceding-token ngrams: . Tot/interceding-token ngrams: kinase modulates FBW7t"interceding-token ngrams: To provet%interceding-token ngrams: treatment ,t:interceding-token ngrams: phosphorylation dependent mannert.interceding-token ngrams: ERK kinase modulatest!interceding-token ngrams: by calft'interceding-token ngrams: To prove thatt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controller:Gene_or_gene_producttwe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_producttnsubj [lemma='kinase'] >nn [lemma='erk'] controllertme1: trigger-arg-path: Positive_regulation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] Gene_or_gene_productt"interceding-token ngrams: that ERKt$interceding-token ngrams: intestinalt#interceding-token ngrams: abolishedt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controller:Gene_or_gene_productt'interceding-token ngrams: phosphatase (t?e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt+interceding-token ngrams: abolished by calft-interceding-token ngrams: indicating that ERKt,interceding-token ngrams: by calf intestinalt%interceding-token ngrams: phosphatasetqe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='fbw7'] >prep_by [lemma='erk'] controllert0interceding-token ngrams: intestinal phosphataset*interceding-token ngrams: was abolished byt4e2: ents2Label-mention-ngram: SHARED kinase directlyt+interceding-token ngrams: modulates FBW7 int^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] Generic_entityt/interceding-token ngrams: endosomal membrane byt5e2: trigger-arg-path: Binding >prep_to Generic_entitytVe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] Generic_entitytUe2: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] theme:Generic_entityt9e2: ents2Label-mention-ngram: the late-endosomal residenttIe2: trigger-arg-path: binding >prep_to [lemma='p14'] Gene_or_gene_producttprep_to [lemma='protein'] theme:Generic_entitytOe2: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] Generic_entitytFe2: trigger-arg-path: binding:Binding >prep_to [lemma='protein'] themet5e2: ents2Label-mention-ngram: late-endosomal residentt(interceding-token ngrams: late endosomestDe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to Generic_entityt#interceding-token ngrams: endosomaltUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] themetWe2: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] theme:Gene_or_gene_productt0interceding-token ngrams: the endosomal membranet&interceding-token ngrams: complexes tot,interceding-token ngrams: these complexes tot"interceding-token ngrams: by meanst%interceding-token ngrams: membrane byt8e2: args2Role-mention-ngram: the late-endosomal residentt"interceding-token ngrams: anchoredt;e2: trigger-arg-path: Binding >prep_to theme:Generic_entityt=e2: trigger-arg-path: binding:Binding >prep_to Generic_entitytBe2: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] themet0e2: ents2Label-mention-ngram: the late-endosomalt;e2: ents2Label-mention-ngram: SHARED , GENE_OR_GENE_PRODUCTtinterceding-token ngrams: meanst"interceding-token ngrams: MP and 1t,interceding-token ngrams: and recruits theset%interceding-token ngrams: is anchoredt-e2: args2Role-mention-ngram: resident THEME ,t!interceding-token ngrams: to latet8e1: ents2Label-mention-ngram: GENERIC_ENTITY interactiont,interceding-token ngrams: endosomal membranet-interceding-token ngrams: complex is anchoredt2interceding-token ngrams: recruits these complexest/e2: args2Role-mention-ngram: the late-endosomalt+e2: args2Role-mention-ngram: resident THEMEt5e2: trigger-arg-path: binding >prep_to Generic_entitytQe2: trigger-arg-path: binding:Binding >prep_to [lemma='p14'] Gene_or_gene_productt interceding-token ngrams: MP andt4e2: ents2Label-mention-ngram: , GENE_OR_GENE_PRODUCTt2e2: args2Role-mention-ngram: to the late-endosomaltGe2: trigger-arg-path: binding >prep_to [lemma='protein'] Generic_entitytLe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to Generic_entityt+interceding-token ngrams: membrane by meanstCe2: trigger-arg-path: binding:Binding >prep_to theme:Generic_entityt+e2: args2Role-mention-ngram: late-endosomalt(interceding-token ngrams: recruits theset-e2: ents2Label-mention-ngram: resident SHAREDt,e2: ents2Label-mention-ngram: late-endosomaltRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to theme:Generic_entityt%e2: args2Role-mention-ngram: residentt/e2: ents2Label-mention-ngram: resident SHARED ,t'interceding-token ngrams: the endosomalt%interceding-token ngrams: by means oft*interceding-token ngrams: to the endosomalt%interceding-token ngrams: anchored tot"interceding-token ngrams: . MP andt%interceding-token ngrams: endosomes .tinterceding-token ngrams: . MPt"interceding-token ngrams: means oft(interceding-token ngrams: is anchored tot)interceding-token ngrams: these complexest>e2: trigger-arg-path: Binding >prep_to [lemma='protein'] themetJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to theme:Generic_entityt>e2: trigger-arg-path: binding >prep_to [lemma='protein'] themet:e2: trigger-arg-path: binding >prep_to [lemma='p14'] themet;e2: trigger-arg-path: binding >prep_to theme:Generic_entityt7CSSPATH: ROOT >conj_and >dobj ++ ROOT >prep_by_means_oft&e2: ents2Label-mention-ngram: residenttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] theme:Generic_entitytinterceding-token ngrams: latet?interceding-tokens-full-span: and recruits these complexes to late endosomes . MP and 1 complex is anchored to the endosomal membrane by means oft3e2: ents2Label-mention-ngram: to the late-endosomaltGe2: trigger-arg-path: Binding >prep_to [lemma='protein'] Generic_entitytOe2: trigger-arg-path: binding >prep_to [lemma='p14'] theme:Gene_or_gene_productt&interceding-token ngrams: 1 complex istinterceding-token ngrams: MPtMe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] theme:Generic_entityt+interceding-token ngrams: to late endosomest(interceding-token ngrams: endosomes . MPt4e2: args2Role-mention-ngram: late-endosomal residenttMe2: trigger-arg-path: binding >prep_to [lemma='protein'] theme:Generic_entityt:e2: args2Role-mention-ngram: late-endosomal resident THEMEt)interceding-token ngrams: anchored to thet e2: ents2Label-mention-ngram: LYt#e2: args2Role-mention-ngram: 294002t8e2: args2Role-mention-ngram: 294002 prevented CONTROLLEDt:e2: ents2Label-mention-ngram: Akt and GENE_OR_GENE_PRODUCTt|e2: trigger-arg-path: prevented:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: inhibitor LYt1e2: args2Role-mention-ngram: prevented CONTROLLEDtne2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllertDe2: trigger-arg-path: prevented >nsubj >prep_of Gene_or_gene_productt0e2: args2Role-mention-ngram: inhibitor LY 294002t0e2: ents2Label-mention-ngram: specific inhibitort0e1: trigger-arg-path: mediated nsubj >prep_of Gene_or_gene_productt1e2: ents2Label-mention-ngram: LY 294002 preventedte2: args2Role-mention-ngram: LYtNe2: trigger-arg-path: prevented:Positive_regulation >nsubj >prep_of controllert)interceding-token ngrams: , inhibition oft/e2: args2Role-mention-ngram: specific inhibitortUe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllertse2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttNe1: trigger-arg-path: mediated:Positive_regulation nsubj >prep_of Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of controllert?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_producttce2: trigger-arg-path: prevented:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: the specific inhibitort0e2: args2Role-mention-ngram: CONTROLLER with thetVe1: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt}e2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: mediated GENE_OR_GENE_PRODUCTt.e2: ents2Label-mention-ngram: prevented SHAREDtre2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt3CSSPATH: ROOT >ccomp >dobj >prep_on >rcmod ++ ROOT t2e2: args2Role-mention-ngram: specific inhibitor LYt?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt.e2: args2Role-mention-ngram: with the specifictee1: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt?e2: trigger-arg-path: prevented:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: LY 294002tJe1: trigger-arg-path: Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert%e2: ents2Label-mention-ngram: Akt andt0e2: args2Role-mention-ngram: LY 294002 preventedt&interceding-token ngrams: , inhibitionte2: trigger: preventedt6e1: ents2Label-mention-ngram: and eNOS phosphorylationt/interceding-token ngrams: contrast , inhibitiontTe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of Gene_or_gene_producttre2: trigger-arg-path: prevented:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controllert-e2: args2Role-mention-ngram: 294002 preventedt%e2: args2Role-mention-ngram: specificte1: outgoing: >rcmodt-e2: ents2Label-mention-ngram: induced Akt andt_e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >prep_of controllertPe1: trigger-arg-path: lemmatizedTrigger=mediate nsubj >prep_of controllertOe2: trigger-arg-path: prevented >nsubj >prep_of controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productthe1: trigger-arg-path: mediated:Positive_regulation prep_to [lemma='Mirk'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='p38'] Gene_or_gene_producttfe2: trigger-arg-path: block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlledt?interceding-tokens-full-span: . In addition , the observation that Mirk protein levels were variable while p38 levels stayed constant suggested that endogenoust)interceding-token ngrams: that endogenoustJe1: trigger-arg-path: Binding >prep_to [lemma='Mirk'] Gene_or_gene_productt'e1: args2Role-mention-ngram: isoforms ,tEe2: trigger-arg-path: block >nsubj [lemma='p38'] Gene_or_gene_productt%interceding-token ngrams: levels weret=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT could onlyt/e1: ents2Label-mention-ngram: or delta isoformst(e1: ents2Label-mention-ngram: isoforms ,t3interceding-token ngrams: stayed constant suggestedt\e2: trigger-arg-path: block >dobj [lemma='function'] >nn [lemma='Mirk'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='p38'] controller:Gene_or_gene_productt'interceding-token ngrams: levels stayedt'e2: args2Role-mention-ngram: only blocktje2: trigger-arg-path: Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] Gene_or_gene_productt*interceding-token ngrams: while p38 levelst*e1: args2Role-mention-ngram: not the gammat;e1: trigger-arg-path: Binding >prep_to [lemma='Mirk'] themet'e1: ents2Label-mention-ngram: , bind tot>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p38betatWe1: trigger-arg-path: bind:Binding >nsubj [lemma='p38alpha'] theme:Gene_or_gene_productt/interceding-token ngrams: observation that Mirkt%e1: args2Role-mention-ngram: or deltatIe2: trigger-arg-path: Negative_activation >nsubj [lemma='p38'] controllertxe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlledt(e2: ents2Label-mention-ngram: only blockt^e2: trigger-arg-path: Negative_activation >nsubj [lemma='p38'] controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38alpha'] Gene_or_gene_producttIe1: trigger-arg-path: bind >nsubj [lemma='p38alpha'] Gene_or_gene_productt interceding-token ngrams: stayedtde2: trigger-arg-path: block:Negative_activation >nsubj [lemma='p38'] controller:Gene_or_gene_productt(interceding-token ngrams: protein levelstOe2: trigger-arg-path: block:Negative_activation >nsubj [lemma='p38'] controllert.interceding-token ngrams: the observation thattae2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='p38'] controllert%interceding-token ngrams: observationt-e1: ents2Label-mention-ngram: isoforms , bindtne2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='function'] >nn [lemma='Mirk'] Gene_or_gene_productt'e2: args2Role-mention-ngram: could onlyt$e1: args2Role-mention-ngram: p38betat+interceding-token ngrams: p38 levels stayedt)e1: ents2Label-mention-ngram: and p38betat#e1: ents2Label-mention-ngram: deltatge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: delta isoforms ,t"e1: args2Role-mention-ngram: deltat%e1: ents2Label-mention-ngram: not thet$e1: args2Role-mention-ngram: not thet&e1: args2Role-mention-ngram: the gammat(e2: ents2Label-mention-ngram: could onlyt&e1: ents2Label-mention-ngram: or deltat?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlled:Gene_or_gene_productt`e2: trigger-arg-path: Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlledt,interceding-token ngrams: constant suggestedtae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38alpha'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: delta isoformst(interceding-token ngrams: addition , thet8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT couldthe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj controller:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj Gene_or_gene_producttOe1: trigger-arg-path: bind >nsubj [lemma='p38alpha'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: could only blockt+e1: ents2Label-mention-ngram: and p38beta ,t#e1: ents2Label-mention-ngram: gammat/e2: ents2Label-mention-ngram: only block SHAREDtye2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='function'] >nn [lemma='Mirk'] controlled:Gene_or_gene_productt(interceding-token ngrams: variable whilet%e1: ents2Label-mention-ngram: p38betat+interceding-token ngrams: , the observationt{e2: trigger-arg-path: block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlled:Gene_or_gene_producttYe2: trigger-arg-path: block:Negative_activation >nsubj [lemma='p38'] Gene_or_gene_productt-interceding-token ngrams: were variable whilet"e1: args2Role-mention-ngram: gammat8e1: trigger-arg-path: bind >prep_to [lemma='Mirk'] themetde2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='function'] >nn [lemma='Mirk'] controlledt,e1: ents2Label-mention-ngram: gamma or deltatRe1: trigger-arg-path: Binding >nsubj [lemma='p38alpha'] theme:Gene_or_gene_productt3interceding-token ngrams: suggested that endogenoust*interceding-token ngrams: observation thatt#CSSPATH: ROOT >advcl ++ ROOT >ccompt+e1: ents2Label-mention-ngram: p38beta , butt+interceding-token ngrams: that Mirk proteint)e1: args2Role-mention-ngram: the gamma ort&interceding-token ngrams: Mirk proteint(e1: args2Role-mention-ngram: and p38betatve2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='p38'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: gamma ort-e1: args2Role-mention-ngram: delta isoforms ,tSe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj controllert=e1: trigger-arg-path: Binding >nsubj [lemma='p38alpha'] themetQe1: trigger-arg-path: bind:Binding >nsubj [lemma='p38alpha'] Gene_or_gene_productt-interceding-token ngrams: Mirk protein levelstinterceding-token ngrams: Mirkt-e2: args2Role-mention-ngram: CONTROLLER couldtGe1: trigger-arg-path: bind >prep_to [lemma='Mirk'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38alpha'] themet)interceding-token ngrams: the observationt.e1: args2Role-mention-ngram: or delta isoformst)e1: ents2Label-mention-ngram: but not thet0interceding-token ngrams: levels stayed constantt&e1: args2Role-mention-ngram: p38beta ,t)interceding-token ngrams: stayed constantt:e1: trigger-arg-path: bind >nsubj [lemma='p38alpha'] themetVe2: trigger-arg-path: block:Negative_activation >nsubj controller:Gene_or_gene_producttUe1: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_producttue2: trigger-arg-path: Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] controlled:Gene_or_gene_productt#interceding-token ngrams: while p38t'e1: ents2Label-mention-ngram: the gammat$interceding-token ngrams: p38 levelst2e2: args2Role-mention-ngram: only block CONTROLLEDtge2: trigger-arg-path: block >dobj [lemma='function'] >nn [lemma='Mirk'] controlled:Gene_or_gene_producttpe2: trigger-arg-path: block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME and p38betat_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt#interceding-token ngrams: that Mirktie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38alpha'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: the gamma ort,e1: ents2Label-mention-ngram: delta isoformst[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38alpha'] Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER could onlyt.interceding-token ngrams: levels were variablet"interceding-token ngrams: variabletLe1: trigger-arg-path: Binding >nsubj [lemma='p38alpha'] Gene_or_gene_producttAe2: trigger-arg-path: block:Negative_activation >nsubj controllertPe2: trigger-arg-path: block >nsubj [lemma='p38'] controller:Gene_or_gene_producttOe1: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: isoformst&e1: ents2Label-mention-ngram: gamma ort?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='function'] >nn [lemma='Mirk'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38alpha'] themet;e2: trigger-arg-path: block >nsubj [lemma='p38'] controllertRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Mirk'] themet-e2: args2Role-mention-ngram: could only blockt&e1: args2Role-mention-ngram: , bind tot1interceding-token ngrams: constant suggested thattMe1: trigger-arg-path: bind >prep_to [lemma='Mirk'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Negative_activation >nsubj [lemma='p38'] Gene_or_gene_producttKe2: trigger-arg-path: block:Negative_activation >nsubj Gene_or_gene_productt&e1: ents2Label-mention-ngram: isoformst+e1: ents2Label-mention-ngram: not the gammat*e1: args2Role-mention-ngram: and p38beta ,t'interceding-token ngrams: were variabletBe1: trigger-arg-path: bind:Binding >nsubj [lemma='p38alpha'] themetRe2: trigger-arg-path: block >dobj [lemma='function'] >nn [lemma='Mirk'] controlledtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Mirk'] themet(e1: args2Role-mention-ngram: but not thet+e1: args2Role-mention-ngram: gamma or deltatke2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='p38'] Gene_or_gene_productt,interceding-token ngrams: variable while p38t*e1: args2Role-mention-ngram: p38beta , butt"interceding-token ngrams: constantt-interceding-token ngrams: protein levels weretae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Mirk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: p38beta ,t@e1: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] themet,e1: args2Role-mention-ngram: isoforms , bindtMe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='p38'] controllert,e1: trigger-arg-path: inhibits >nsubj Familyt9e2: trigger-arg-path: Binding >nsubj [lemma='arf'] Familyt0e2: trigger-arg-path: interact >prep_with FamilytSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='arf'] themetEe2: trigger-arg-path: interact >prep_with [lemma='espg'] theme:Familyt%interceding-token ngrams: activity bytinterceding-token ngrams: PAK .tRe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='arf'] theme:Familyt.interceding-token ngrams: activating protein (t.interceding-token ngrams: activity by blockingtKe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlled:Familytae1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='Arf'] Familytde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='espg'] controllert-interceding-token ngrams: thus GTP hydrolysist*interceding-token ngrams: GTP hydrolysis ,tFe1: trigger-arg-path: inhibits >nsubj [lemma='espg'] controller:Familyt!interceding-token ngrams: ( GAP )t_e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlledtPe1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='Arf'] Familyt7e1: trigger-arg-path: inhibits >nsubj controller:Familyt=e2: trigger-arg-path: Binding >prep_with [lemma='espg'] themet3interceding-token ngrams: GTPase activating proteintde1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] Familytoe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlled:FamilytJe1: trigger-arg-path: Negative_activation >nsubj [lemma='espg'] controllert$e2: args2Role-mention-ngram: and PAKt interceding-token ngrams: of PAKtPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='espg'] themet)e2: args2Role-mention-ngram: PAK interactt/e1: trigger-arg-path: inhibits >dobj >nn Familyt:e1: trigger-arg-path: inhibits >dobj >nn controlled:FamilytZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='arf'] theme:Familyt$interceding-token ngrams: hydrolysist6e2: trigger-arg-path: interact >prep_with theme:Familyt9e2: trigger-arg-path: interact >nsubj [lemma='arf'] themet,interceding-token ngrams: by blocking GTPasetAe2: trigger-arg-path: interact:Binding >nsubj [lemma='arf'] themet*interceding-token ngrams: activator of PAKtHe2: trigger-arg-path: interact:Binding >nsubj [lemma='arf'] theme:Familyt"interceding-token ngrams: thus GTPtWe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='espg'] theme:Familyt?interceding-tokens-full-span: GTPase activity by blocking GTPase activating protein ( GAP ) binding and thus GTP hydrolysis , while at the same time acting as an allosteric activator of PAK . Botht,interceding-token ngrams: hydrolysis , whilet#interceding-token ngrams: ) bindingtQe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='espg'] FamilytCe1: trigger-arg-path: inhibits:Negative_activation >dobj >nn Familyt@e1: trigger-arg-path: inhibits:Negative_activation >nsubj FamilytBe2: trigger-arg-path: interact:Binding >nsubj [lemma='arf'] FamilytQe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj FamilytQe1: trigger-arg-path: Negative_activation >nsubj [lemma='espg'] controller:FamilytLe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='espg'] Familyt&interceding-token ngrams: acting as antFe1: trigger-arg-path: Negative_activation >nsubj [lemma='espg'] Familyt>e2: trigger-arg-path: Binding >prep_with [lemma='espg'] Familyt$interceding-token ngrams: PAK . Botht?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlled:Familyt'interceding-token ngrams: GAP ) bindingt'interceding-token ngrams: an allosterict"interceding-token ngrams: of PAK .tinterceding-token ngrams: as antMe2: trigger-arg-path: interact:Binding >prep_with [lemma='espg'] theme:Familytinterceding-token ngrams: BothtWe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='espg'] controller:FamilytXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='espg'] themet#interceding-token ngrams: protein (t@e2: trigger-arg-path: interact >nsubj [lemma='arf'] theme:Familyt?e2: trigger-arg-path: interact >prep_with [lemma='espg'] Familyt4interceding-token ngrams: blocking GTPase activatingt4e1: ents2Label-mention-ngram: SHARED inhibits SHAREDt$interceding-token ngrams: allosterict&interceding-token ngrams: and thus GTPt'interceding-token ngrams: ) binding andt&interceding-token ngrams: activator oftFe2: trigger-arg-path: interact:Binding >prep_with [lemma='espg'] themet#interceding-token ngrams: same timet(interceding-token ngrams: GTP hydrolysistLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='arf'] Familyt;e1: trigger-arg-path: inhibits >nsubj [lemma='espg'] Familyt1interceding-token ngrams: an allosteric activatort.e2: args2Role-mention-ngram: PAK interact witht.e2: ents2Label-mention-ngram: and PAK interactt+interceding-token ngrams: GTPase activatingt)interceding-token ngrams: blocking GTPasetinterceding-token ngrams: timetKe1: trigger-arg-path: inhibits:Negative_activation >nsubj controller:Familyt*e2: args2Role-mention-ngram: THEME and PAKt&interceding-token ngrams: while at thet[e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] FamilytGe2: trigger-arg-path: interact:Binding >prep_with [lemma='espg'] Familyt,e2: ents2Label-mention-ngram: SHARED and PAKt?e2: trigger-arg-path: Binding >nsubj [lemma='arf'] theme:Familyt\e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:FamilytNe1: trigger-arg-path: inhibits:Negative_activation >dobj >nn controlled:FamilytDe2: trigger-arg-path: Binding >prep_with [lemma='espg'] theme:Familyt8e2: trigger-arg-path: Binding >nsubj [lemma='arf'] themet*interceding-token ngrams: as an allosterictinterceding-token ngrams: GAP )t[e1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='Arf'] controlled:Familyt=e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Familyt7e1: trigger-arg-path: Negative_activation >nsubj Familytle1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='Arf'] controlled:Familyt interceding-token ngrams: . Bothtue1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] Familyt$interceding-token ngrams: , while att%interceding-token ngrams: binding andt8e2: trigger-arg-path: interact:Binding >prep_with Familyt>e2: trigger-arg-path: interact:Binding >prep_with theme:Familyt1interceding-token ngrams: allosteric activator oft(interceding-token ngrams: time acting astOe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='espg'] FamilytKe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='arf'] themetPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='espg'] controllert,interceding-token ngrams: activating proteint%e2: ents2Label-mention-ngram: and PAKt_e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='espg'] theme:FamilytTe1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='Arf'] controlledt*interceding-token ngrams: binding and thust#interceding-token ngrams: activatortBe1: trigger-arg-path: Negative_activation >nsubj controller:Familyt>e2: trigger-arg-path: interact >prep_with [lemma='espg'] themetHe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:FamilytTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='arf'] Familyt"interceding-token ngrams: while atthe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlledt'interceding-token ngrams: protein ( GAPt)interceding-token ngrams: GTPase activitytSe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='espg'] controllert%interceding-token ngrams: at the sametZe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='espg'] controller:Familyt*interceding-token ngrams: same time actingtye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlledt&interceding-token ngrams: hydrolysis ,t@e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn Familyt interceding-token ngrams: actingt:e2: trigger-arg-path: interact >nsubj [lemma='arf'] Familyt?e1: trigger-arg-path: inhibits >nsubj [lemma='espg'] controllertTe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn FamilytYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='espg'] Familyt*e2: ents2Label-mention-ngram: PAK interactt.interceding-token ngrams: allosteric activatort#interceding-token ngrams: acting ast,interceding-token ngrams: GTPase activity byt/e2: ents2Label-mention-ngram: PAK interact witht-e2: args2Role-mention-ngram: and PAK interacttke1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='espg'] controller:Familytee1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='Arf'] controlledt`e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='espg'] Familyt_e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlled:Familytinterceding-token ngrams: ( GAPt'interceding-token ngrams: the same timetfe1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='Arf'] controlled:Familyt%interceding-token ngrams: time actingt'e2: ents2Label-mention-ngram: low-levelt-interceding-token ngrams: signaling includingt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Gal-3'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: Gal-3 augmentedtinterceding-token ngrams: downt&e2: args2Role-mention-ngram: low-levelt^e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt)interceding-token ngrams: activity ; downt1e2: args2Role-mention-ngram: with low-level Gal-3toe2: trigger-arg-path: augmented:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt(interceding-token ngrams: and maintainedt?e2: trigger-arg-path: augmented:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: augmentedtSe2: trigger-arg-path: augmented >nsubj >prep_of >nn controller:Gene_or_gene_productt~e2: trigger-arg-path: Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controllert>e2: trigger-arg-path: augmented >nsubj >prep_of >nn controllert?e2: trigger-arg-path: Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=augment >dobj [lemma='activity'] >nn [lemma='ra'] Familyt&e2: args2Role-mention-ngram: augmentedtte2: trigger-arg-path: augmented >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controllertge2: trigger-arg-path: augmented:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt,interceding-token ngrams: as Ras down-streamt,interceding-token ngrams: of Gal-3 decreasedtZe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt2e2: ents2Label-mention-ngram: with low-level Gal-3t&interceding-token ngrams: Transfectiont9interceding-token ngrams: down-stream signaling includingtce2: trigger-arg-path: lemmatizedTrigger=augment >nsubj >prep_of >nn controller:Gene_or_gene_productt)interceding-token ngrams: Transfection oft)e2: ents2Label-mention-ngram: SHARED cDNAtGe1: trigger-arg-path: bound >nsubj [lemma='Gal-3'] Gene_or_gene_productt4e2: trigger-arg-path: augmented >dobj >nn controlledt1e2: args2Role-mention-ngram: CONTROLLER cDNA intot?e2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controllertIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Gal-3'] themetPe2: trigger-arg-path: augmented >dobj [lemma='activity'] >nn [lemma='ra'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj >nn controlled:Familyt(e2: ents2Label-mention-ngram: cells witht"interceding-token ngrams: of Gal-3t(interceding-token ngrams: Ras activity ;t%interceding-token ngrams: well as Rast"e2: args2Role-mention-ngram: Gal-3t&interceding-token ngrams: A activity .t interceding-token ngrams: as Rast,interceding-token ngrams: and maintained Rast'interceding-token ngrams: regulation oft?e2: trigger-arg-path: Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controller:Gene_or_gene_productt(interceding-token ngrams: . Transfectiont(e2: ents2Label-mention-ngram: PDAC cellst'e2: args2Role-mention-ngram: cells withtTe2: trigger-arg-path: augmented >dobj [lemma='activity'] >nn [lemma='ra'] controlledt$interceding-token ngrams: maintainedt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Gal-3'] Gene_or_gene_productt,e2: args2Role-mention-ngram: CONTROLLER cDNAt@e2: trigger-arg-path: lemmatizedTrigger=augment >dobj >nn Familyt%interceding-token ngrams: ERK and AKTt1e2: args2Role-mention-ngram: cells with low-levelt$interceding-token ngrams: A activityte2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt#e2: ents2Label-mention-ngram: Gal-3t'e2: args2Role-mention-ngram: PDAC cellst1interceding-token ngrams: maintained Ras activityt2e2: ents2Label-mention-ngram: cells with low-levelthe2: trigger-arg-path: augmented:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledtRe2: trigger-arg-path: augmented:Positive_activation >nsubj >prep_of >nn controllert!e2: args2Role-mention-ngram: intot"e2: ents2Label-mention-ngram: cDNAt.e2: ents2Label-mention-ngram: SHARED cDNA intotOe1: trigger-arg-path: bound:Binding >nsubj [lemma='Gal-3'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Gal-3'] themet-interceding-token ngrams: regulation of Gal-3t%interceding-token ngrams: activity ast1e2: args2Role-mention-ngram: augmented CONTROLLEDt*interceding-token ngrams: activity as welltee2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:FamilytDe2: trigger-arg-path: lemmatizedTrigger=augment >dobj >nn controlledtNe2: trigger-arg-path: lemmatizedTrigger=augment >nsubj >prep_of >nn controllert1interceding-token ngrams: activity . Transfectiontinterceding-token ngrams: At$interceding-token ngrams: activity ;tXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Gal-3'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt(interceding-token ngrams: maintained Rast~e2: trigger-arg-path: augmented >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] Gene_or_gene_productt,interceding-token ngrams: down regulation oftte2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt-interceding-token ngrams: Gal-3 decreased Rast.e2: ents2Label-mention-ngram: augmented SHAREDt+e2: args2Role-mention-ngram: cDNA into PDACt+interceding-token ngrams: ; down regulationt&e2: args2Role-mention-ngram: cDNA intot?e2: trigger-arg-path: augmented >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='Gal-3'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: cDNA into PDACtMe1: trigger-arg-path: bound >nsubj [lemma='Gal-3'] theme:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj >prep_of >nn controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: cDNA intotHe2: trigger-arg-path: augmented:Positive_activation >dobj >nn controlledtHe2: trigger-arg-path: augmented >nsubj >prep_of >nn Gene_or_gene_productt'interceding-token ngrams: decreased Rast7e2: args2Role-mention-ngram: Gal-3 augmented CONTROLLEDt?interceding-tokens-full-span: and maintained Ras activity ; down regulation of Gal-3 decreased Ras activity as well as Ras down-stream signaling including phosphorylation of ERK and AKT and Ral A activity . Transfection oft)interceding-token ngrams: Ras activity astxe2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt%interceding-token ngrams: down-streamt6e2: args2Role-mention-ngram: low-level Gal-3 augmentedtinterceding-token ngrams: Ral At!interceding-token ngrams: AKT andt interceding-token ngrams: of ERKtTe2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj >nn Familyt-e2: ents2Label-mention-ngram: low-level Gal-3tOe2: trigger-arg-path: augmented:Positive_activation >dobj >nn controlled:Familyt?e2: trigger-arg-path: lemmatizedTrigger=augment >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] Gene_or_gene_productt[e2: trigger-arg-path: augmented >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familytinterceding-token ngrams: Gal-3t-e2: ents2Label-mention-ngram: PDAC cells witht4e2: ents2Label-mention-ngram: Gal-3 augmented SHAREDtke2: trigger-arg-path: lemmatizedTrigger=augment >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt!e2: args2Role-mention-ngram: PDACt interceding-token ngrams: ; downt?e2: trigger-arg-path: augmented:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controllert:e1: trigger-arg-path: Binding >nsubj [lemma='Gal-3'] themet-e2: ents2Label-mention-ngram: into PDAC cellst8e1: trigger-arg-path: bound >nsubj [lemma='Gal-3'] themet%interceding-token ngrams: AKT and Ralt?e2: trigger-arg-path: lemmatizedTrigger=augment >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controllertDe2: trigger-arg-path: augmented:Positive_activation >dobj >nn Familyt)interceding-token ngrams: down regulationt6interceding-token ngrams: including phosphorylation oft=interceding-token ngrams: signaling including phosphorylationt)interceding-token ngrams: Ras down-streamt0interceding-token ngrams: phosphorylation of ERKt,e2: args2Role-mention-ngram: PDAC cells witht?e2: trigger-arg-path: augmented:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controller:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='Gal-3'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] Gene_or_gene_producttinterceding-token ngrams: AKTtUe1: trigger-arg-path: bound:Binding >nsubj [lemma='Gal-3'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=augment >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controller:Gene_or_gene_producttde2: trigger-arg-path: augmented:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] FamilytKe2: trigger-arg-path: lemmatizedTrigger=augment >dobj >nn controlled:Familyt&e2: args2Role-mention-ngram: into PDACt"e2: ents2Label-mention-ngram: intot,e2: args2Role-mention-ngram: into PDAC cellst?e2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj [lemma='transfection'] >prep_of [lemma='cdna'] >nn [lemma='gal-3'] controller:Gene_or_gene_productt@e1: trigger-arg-path: bound:Binding >nsubj [lemma='Gal-3'] themet,e2: ents2Label-mention-ngram: with low-levelt$interceding-token ngrams: of ERK andt+e2: args2Role-mention-ngram: with low-levelt!interceding-token ngrams: and AKTtde2: trigger-arg-path: lemmatizedTrigger=augment >dobj [lemma='activity'] >nn [lemma='ra'] controlledt'e2: ents2Label-mention-ngram: into PDACtbe2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >nsubj >prep_of >nn controllert#interceding-token ngrams: and Ral At7e2: ents2Label-mention-ngram: low-level Gal-3 augmentedt;e2: trigger-arg-path: augmented >dobj >nn controlled:FamilytXe2: trigger-arg-path: lemmatizedTrigger=augment:Positive_activation >dobj >nn controlledt0e2: trigger-arg-path: augmented >dobj >nn Familyt#interceding-token ngrams: includingtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Gal-3'] theme:Gene_or_gene_productt%interceding-token ngrams: and AKT andt\e2: trigger-arg-path: augmented:Positive_activation >nsubj >prep_of >nn Gene_or_gene_productt+interceding-token ngrams: . Transfection oft-e2: ents2Label-mention-ngram: Gal-3 augmentedt)interceding-token ngrams: Gal-3 decreasedtinterceding-token ngrams: Ralt3interceding-token ngrams: Ras down-stream signalingt!interceding-token ngrams: and Ralt/interceding-token ngrams: down-stream signalingt(interceding-token ngrams: Ral A activityt3interceding-token ngrams: including phosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=augment >nsubj >prep_of >nn Gene_or_gene_productt,e2: args2Role-mention-ngram: low-level Gal-3t0interceding-token ngrams: decreased Ras activityt!e2: args2Role-mention-ngram: cDNAte2: trigger: augmentedt5e2: args2Role-mention-ngram: regulation of CONTROLLEDtHe2: trigger-arg-path: Positive_regulation >dobj >prep_of PhosphorylationtNe2: trigger-arg-path: Positive_regulation agent >prep_of >nn controllert+e2: ents2Label-mention-ngram: regulation oftce1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent >prep_of >nn controllertwe2: trigger-arg-path: mediated >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt{e2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlledtTe2: trigger-arg-path: lemmatizedTrigger=mediate e1: trigger-arg-path: decreased >agent >prep_of >nn controllert\e2: trigger-arg-path: mediated:Positive_regulation >dobj >prep_of controlled:Phosphorylationt?e1: trigger-arg-path: Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controllertYe1: trigger-arg-path: decreased:Positive_regulation >agent >prep_of >nn controller:Familytre2: trigger-arg-path: Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlledt$interceding-token ngrams: - MEFs wast!interceding-token ngrams: F-actint+interceding-token ngrams: by transformationtIe2: trigger-arg-path: lemmatizedTrigger=mediate dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlledtae2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controller:Familyt'interceding-token ngrams: the amount oft?e1: trigger-arg-path: Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controller:Familyt.e1: args2Role-mention-ngram: by the inhibitiont|e1: trigger-arg-path: decreased >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controllert-interceding-token ngrams: therefore oncogenictMe2: trigger-arg-path: lemmatizedTrigger=mediate agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controller:Familyt5e1: ents2Label-mention-ngram: significantly decreasedt"e2: ents2Label-mention-ngram: downt*interceding-token ngrams: was not affectedtje1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent >prep_of >nn controller:FamilytLe2: trigger-arg-path: mediated:Positive_regulation >dobj >prep_of controlledtbe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj >prep_of PhosphorylationtAe2: trigger-arg-path: Positive_regulation dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj >prep_of controlled:PhosphorylationtIe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj >prep_of controlledt?interceding-tokens-full-span: polymerization in nontransformed cells . Importantly , the amount of F-actin in p53 -/ - MEFs was not affected by transformation and therefore oncogenict/e1: ents2Label-mention-ngram: was significantlyt&interceding-token ngrams: MEFs was nottDe1: trigger-arg-path: Positive_regulation >agent >prep_of >nn Familyt0e2: ents2Label-mention-ngram: down regulation oftJe2: trigger-arg-path: mediated:Positive_regulation dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlledt?e2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt_e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent >prep_of >nn FamilytQe2: trigger-arg-path: mediated:Positive_regulation >dobj >prep_of PhosphorylationtRe1: trigger-arg-path: decreased:Positive_regulation >agent >prep_of >nn controllert/e1: ents2Label-mention-ngram: the inhibition oft?e2: trigger-arg-path: Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt6e2: trigger-arg-path: mediated dobj >prep_of controlled:PhosphorylationtPe2: trigger-arg-path: mediated:Positive_regulation agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] FamilytGe2: trigger-arg-path: Positive_regulation agent >prep_of >nn Familyt(interceding-token ngrams: transformationt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] FamilytHe1: trigger-arg-path: Positive_regulation >agent >prep_of >nn controllert-e2: ents2Label-mention-ngram: down regulationt)interceding-token ngrams: . Importantly ,t5e1: ents2Label-mention-ngram: Phosphorylation of botht1interceding-token ngrams: and therefore oncogenict?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] Phosphorylationt$interceding-token ngrams: F-actin int?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controllert'interceding-token ngrams: of F-actin int?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controller:Familyt#interceding-token ngrams: oncogenict?e1: trigger-arg-path: decreased:Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controllert]e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] Familyt6e2: trigger-arg-path: Positive_regulation agent >prep_of >nn Familyt(interceding-token ngrams: F-actin in p53t4interceding-token ngrams: affected by transformationt?e1: trigger-arg-path: Positive_regulation >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] Familyt$interceding-token ngrams: the amountt-e2: ents2Label-mention-ngram: FAMILY mediatedt"interceding-token ngrams: MEFs wast2e2: ents2Label-mention-ngram: FAMILY mediated downt$interceding-token ngrams: of F-actint]e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj >prep_of controlledt:e1: ents2Label-mention-ngram: FAK and GENE_OR_GENE_PRODUCTt6e2: ents2Label-mention-ngram: mediated down regulationt/e1: ents2Label-mention-ngram: by the inhibitiont}e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] Phosphorylationt/interceding-token ngrams: by transformation andt-interceding-token ngrams: cells . Importantlyt,e2: args2Role-mention-ngram: down regulationtVe1: trigger-arg-path: lemmatizedTrigger=decrease >agent >prep_of >nn controller:Familyt%interceding-token ngrams: Importantlyt?e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlled:Phosphorylationt%e1: ents2Label-mention-ngram: FAK andt1interceding-token ngrams: in nontransformed cellst*e2: args2Role-mention-ngram: mediated downt,interceding-token ngrams: transformation andt&e1: ents2Label-mention-ngram: both FAKt(e2: ents2Label-mention-ngram: regulationt'interceding-token ngrams: Importantly ,tle2: trigger-arg-path: mediated >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] Phosphorylationt5e2: args2Role-mention-ngram: CONTROLLER mediated downt0interceding-token ngrams: nontransformed cells .t-e1: args2Role-mention-ngram: decreased by thetdobj >prep_of controlled:Phosphorylationt@e2: ents2Label-mention-ngram: regulation of GENE_OR_GENE_PRODUCTt#interceding-token ngrams: amount oft*e1: ents2Label-mention-ngram: decreased bytEe1: trigger-arg-path: decreased >agent >prep_of >nn controller:FamilytCe2: trigger-arg-path: Positive_regulation agent >prep_of >nn controller:Familyt1CSSPATH: ROOT  ++ ROOT >conj_and >nsubjpass >vmodt+interceding-token ngrams: polymerization int!e2: args2Role-mention-ngram: downt8e2: trigger-arg-path: mediated prttHe2: trigger-arg-path: mediated >dobj >prep_of controlled:PhosphorylationtCe2: trigger-arg-path: Positive_regulation >dobj >prep_of controlledtxe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] controlledtNe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj >prep_of Phosphorylationt%interceding-token ngrams: affected byt#interceding-token ngrams: in p53 -/t"interceding-token ngrams: affectedt:interceding-token ngrams: polymerization in nontransformedt8e2: trigger-arg-path: mediated >dobj >prep_of controlledt5e2: args2Role-mention-ngram: mediated down regulationt?e1: trigger-arg-path: lemmatizedTrigger=decrease >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controllert.e1: args2Role-mention-ngram: was significantlyt interceding-token ngrams: in p53t8e1: ents2Label-mention-ngram: significantly decreased byt+e2: trigger-arg-path: mediated dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] Phosphorylationtwe2: trigger-arg-path: Positive_regulation >dobj [lemma='regulation'] >prep_of [lemma='phosphorylation'] Phosphorylationt)interceding-token ngrams: not affected bytWe2: trigger-arg-path: mediated:Positive_regulation agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] Familyt=e2: trigger-arg-path: mediated >dobj >prep_of Phosphorylationt+e1: args2Role-mention-ngram: the inhibitiontLe2: trigger-arg-path: mediated:Positive_regulation agent >prep_of >nn Familyt(interceding-token ngrams: polymerizationt+interceding-token ngrams: in nontransformedt?e1: trigger-arg-path: decreased >agent [lemma='inhibition'] >prep_of [lemma='polymerization'] >nn [lemma='actin'] controller:Familythe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dobj [lemma='Groucho'] themet#interceding-token ngrams: ( Choi ettBe2: trigger-arg-path: interacts:Binding >dobj Gene_or_gene_productt#e2: ents2Label-mention-ngram: ( Kimtinterceding-token ngrams: HIPK2t#e2: ents2Label-mention-ngram: , ) ,t'interceding-token ngrams: Drosophila tot#interceding-token ngrams: to humanst#e2: ents2Label-mention-ngram: ; Kimt!e2: ents2Label-mention-ngram: al.tOe2: trigger-arg-path: Binding >nsubj [lemma='hipk2'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: Hofmann et al.t+e2: ents2Label-mention-ngram: Aikawa et al.tTe2: trigger-arg-path: interacts:Binding >dobj [lemma='Groucho'] Gene_or_gene_productt'e2: args2Role-mention-ngram: Hofmann ett%e2: args2Role-mention-ngram: et al. ,t*e2: ents2Label-mention-ngram: ( D'Orazi ett*e2: ents2Label-mention-ngram: the p300 andt$e2: ents2Label-mention-ngram: Kim ettne1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='wsb1'] controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: Aikawat'e2: ents2Label-mention-ngram: a varietyt'e2: args2Role-mention-ngram: variety oftSe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj Gene_or_gene_productt*e2: ents2Label-mention-ngram: p300 and CBPt.interceding-token ngrams: Drosophila to humanst)e2: ents2Label-mention-ngram: , ; HofmanntUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hipk2'] themet.e2: ents2Label-mention-ngram: interacts with at0e2: ents2Label-mention-ngram: CBP co-activator (t'e2: ents2Label-mention-ngram: ; HofmanntRe2: trigger-arg-path: interacts >dobj [lemma='Groucho'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: ; Hofmannt]e2: trigger-arg-path: lemmatizedTrigger=interact >dobj [lemma='Groucho'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: CBPt%interceding-token ngrams: Choi et al.t&e2: args2Role-mention-ngram: a varietyt0e2: ents2Label-mention-ngram: co-activator ( Kimt2e2: ents2Label-mention-ngram: and CBP co-activatort$e2: args2Role-mention-ngram: ) , andt'interceding-token ngrams: humans ( Choitdobj themet#interceding-token ngrams: a nucleart&e2: args2Role-mention-ngram: , and thet/e2: args2Role-mention-ngram: CBP co-activator (t:e2: trigger-arg-path: interacts >dobj Gene_or_gene_productt'e2: ents2Label-mention-ngram: , and thet#interceding-token ngrams: ( HIPK2 )tVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj [lemma='Groucho'] themet&e2: ents2Label-mention-ngram: ; Kim ett3e2: ents2Label-mention-ngram: transcription factorst$e2: args2Role-mention-ngram: al. , ;tme1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='wsb1'] controllert$e2: args2Role-mention-ngram: al. , )te2: args2Role-mention-ngram: ;t"e2: args2Role-mention-ngram: Zhangt(e2: ents2Label-mention-ngram: D'Orazi ett%e2: ents2Label-mention-ngram: , ; Kimt&e2: ents2Label-mention-ngram: et al. ,t%interceding-token ngrams: and is welltJe2: trigger-arg-path: Binding >dobj [lemma='Groucho'] Gene_or_gene_productt/e2: args2Role-mention-ngram: co-activator ( Kimt,interceding-token ngrams: protein kinase andt*e2: ents2Label-mention-ngram: Zhang et al.t-e2: args2Role-mention-ngram: interacts with at$e2: args2Role-mention-ngram: Hofmanntde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hipk2'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: ; Aikawa ett0interceding-token ngrams: nuclear protein kinaset(e2: ents2Label-mention-ngram: ; Zhang ett'e2: args2Role-mention-ngram: D'Orazi ett%e2: ents2Label-mention-ngram: and CBPtKe2: trigger-arg-path: interacts >nsubj [lemma='hipk2'] Gene_or_gene_productt interceding-token ngrams: humanst]e1: trigger-arg-path: polyubiquitinates >nsubj [lemma='wsb1'] controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: ( D'Orazi ett#e2: ents2Label-mention-ngram: Zhangt6e2: ents2Label-mention-ngram: of transcription factorst6e2: ents2Label-mention-ngram: variety of transcriptiont'e2: args2Role-mention-ngram: ; Zhang ett#e2: args2Role-mention-ngram: Aikawat(e2: args2Role-mention-ngram: , ; Hofmanntnsubj [lemma='hipk2'] themetfe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='wsb1'] Gene_or_gene_productt$interceding-token ngrams: DrosophilatHe1: trigger-arg-path: polyubiquitinates >nsubj [lemma='wsb1'] controllert#e2: args2Role-mention-ngram: Kim ett+interceding-token ngrams: is well conservedt)e2: args2Role-mention-ngram: p300 and CBPt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='wsb1'] controller:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hipk2'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: transcription factors (tinterceding-token ngrams: , , )tIe2: trigger-arg-path: Binding >nsubj [lemma='hipk2'] Gene_or_gene_productt$e2: args2Role-mention-ngram: ; ZhangtYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj theme:Gene_or_gene_productt&interceding-token ngrams: is a nucleart!e2: ents2Label-mention-ngram: , ;t*e2: ents2Label-mention-ngram: ; Hofmann ette2: outgoing: >rcmodt;e2: trigger-arg-path: Binding >dobj [lemma='Groucho'] themet=e2: trigger-arg-path: interacts >dobj [lemma='Groucho'] themet$e2: args2Role-mention-ngram: , ; Kimt5e2: args2Role-mention-ngram: variety of transcriptionte2: ents2Label-mention-ngram: ;t,interceding-token ngrams: from Drosophila tot!e2: ents2Label-mention-ngram: , )t e2: args2Role-mention-ngram: al.t@e2: trigger-arg-path: interacts >dobj theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='wsb1'] controller:Gene_or_gene_producttEe2: trigger-arg-path: interacts:Binding >dobj [lemma='Groucho'] themet e2: args2Role-mention-ngram: CBPt'e2: ents2Label-mention-ngram: Aikawa ett!e2: ents2Label-mention-ngram: Kimt,e2: ents2Label-mention-ngram: D'Orazi et al.t&e2: args2Role-mention-ngram: Aikawa ettQe2: trigger-arg-path: interacts >nsubj [lemma='hipk2'] theme:Gene_or_gene_productt\e1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='wsb1'] controllert$e2: args2Role-mention-ngram: and CBPt$interceding-token ngrams: kinase andt%e2: args2Role-mention-ngram: ( Kim ettDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT polyubiquitinatest+e2: args2Role-mention-ngram: D'Orazi et al.t!interceding-token ngrams: Choi ett%e2: args2Role-mention-ngram: the p300tqe1: trigger-arg-path: polyubiquitinates:Positive_regulation >nsubj [lemma='wsb1'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate:Positive_regulation >nsubj [lemma='wsb1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: ; Aikawa ettDe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hipk2'] themet+e2: trigger-arg-path: interacts >dobj themet%e2: ents2Label-mention-ngram: D'Orazit)e2: args2Role-mention-ngram: the p300 andt)e2: args2Role-mention-ngram: Zhang et al.t*e2: ents2Label-mention-ngram: a variety oft5e2: args2Role-mention-ngram: of transcription factorst!interceding-token ngrams: al. , ,tQe2: trigger-arg-path: lemmatizedTrigger=interact >dobj theme:Gene_or_gene_productt!interceding-token ngrams: ( HIPK2tMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hipk2'] themet#interceding-token ngrams: 2 ( HIPK2t'e2: ents2Label-mention-ngram: ( D'Orazit&e2: args2Role-mention-ngram: ( D'Orazit!interceding-token ngrams: HIPK2 )t'e2: ents2Label-mention-ngram: , ; Zhangt%e2: args2Role-mention-ngram: Zhang ettHe2: trigger-arg-path: interacts:Binding >dobj theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: CBP co-activatortYe1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='wsb1'] controllert$interceding-token ngrams: which is at&e2: args2Role-mention-ngram: , ; Zhangtbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='hipk2'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: co-activatort$e2: args2Role-mention-ngram: factorst%e2: ents2Label-mention-ngram: varietytTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='wsb1'] Gene_or_gene_producttZe2: trigger-arg-path: interacts:Binding >dobj [lemma='Groucho'] theme:Gene_or_gene_productt?interceding-tokens-full-span: 2 ( HIPK2 ) , which is a nuclear protein kinase and is well conserved from Drosophila to humans ( Choi et al. , , ) .t&e2: ents2Label-mention-ngram: ( Kim ettPe2: trigger-arg-path: Binding >dobj [lemma='Groucho'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: ; Hofmann ett'e2: args2Role-mention-ngram: Kim et al.tJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='wsb1'] controllert"e2: args2Role-mention-ngram: al. ,tce1: trigger-arg-path: lemmatizedTrigger=polyubiquitinate >nsubj [lemma='wsb1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact >dobj [lemma='Groucho'] theme:Gene_or_gene_producttDe1: ents2Label-mention-ngram: polyubiquitinates GENE_OR_GENE_PRODUCTtRe1: trigger-arg-path: polyubiquitinates >nsubj [lemma='wsb1'] Gene_or_gene_productt%interceding-token ngrams: to humans (t#e2: ents2Label-mention-ngram: al. ,t'e2: args2Role-mention-ngram: , the p300tje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='hipk2'] theme:Gene_or_gene_producttYe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT polyubiquitinates GENE_OR_GENE_PRODUCTt)interceding-token ngrams: nuclear proteint&e2: ents2Label-mention-ngram: the p300tinterceding-token ngrams: Choit%e2: args2Role-mention-ngram: p300 andtLe2: trigger-arg-path: interacts >dobj [lemma='Groucho'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: al. , ;t&e2: args2Role-mention-ngram: factors (t e2: args2Role-mention-ngram: , ;tDe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj themet%e2: ents2Label-mention-ngram: al. , )tee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj [lemma='Groucho'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: Zhang ettYe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hipk2'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: factors ( D'Orazit(e2: ents2Label-mention-ngram: Kim et al.t%e2: ents2Label-mention-ngram: ) , andt2e2: args2Role-mention-ngram: transcription factorst e2: args2Role-mention-ngram: , )t)e2: args2Role-mention-ngram: a variety oft3interceding-token ngrams: conserved from Drosophilat%e2: args2Role-mention-ngram: ; Aikawat-interceding-token ngrams: well conserved fromt(interceding-token ngrams: conserved fromt'e2: ents2Label-mention-ngram: factors (t(e2: ents2Label-mention-ngram: , the p300te2: args2Role-mention-ngram: ett$e2: ents2Label-mention-ngram: et al.t)e2: args2Role-mention-ngram: co-activatort interceding-token ngrams: ( Choit*e2: args2Role-mention-ngram: Aikawa et al.t(interceding-token ngrams: well conservedt+interceding-token ngrams: a nuclear proteintKe2: trigger-arg-path: lemmatizedTrigger=interact >dobj Gene_or_gene_productt e2: args2Role-mention-ngram: Kimt#interceding-token ngrams: HIPK2 ) ,t:e2: ents2Label-mention-ngram: and the GENE_OR_GENE_PRODUCTt#e2: args2Role-mention-ngram: et al.t&e2: ents2Label-mention-ngram: p300 andt(e2: ents2Label-mention-ngram: , ; Aikawat%e2: ents2Label-mention-ngram: Hofmannt e2: ents2Label-mention-ngram: ett,e2: ents2Label-mention-ngram: with a varietyt3e2: trigger-arg-path: interacts:Binding >dobj themet4e2: args2Role-mention-ngram: transcription factors (t1e2: args2Role-mention-ngram: and CBP co-activatort'interceding-token ngrams: kinase and ist"interceding-token ngrams: humans (t$e2: args2Role-mention-ngram: D'Orazit+e2: args2Role-mention-ngram: with a varietyt+e2: args2Role-mention-ngram: co-activator (t"e2: args2Role-mention-ngram: , ) ,t!interceding-token ngrams: is wellt&e2: ents2Label-mention-ngram: ; Aikawat-e2: args2Role-mention-ngram: CBP co-activatort/e2: ents2Label-mention-ngram: factors ( D'Orazit"e2: args2Role-mention-ngram: ; Kimt"e2: args2Role-mention-ngram: ( Kimtke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >dobj [lemma='Groucho'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interacts:Binding >nsubj [lemma='hipk2'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: Hofmann ett%e2: args2Role-mention-ngram: ; Kim ett%e2: ents2Label-mention-ngram: ; Zhangt:e2: trigger-arg-path: Binding >nsubj [lemma='hipk2'] themet'e2: args2Role-mention-ngram: , ; Aikawat,e2: ents2Label-mention-ngram: co-activator (tJe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] themet,e2: args2Role-mention-ngram: directly to thetae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='stat-1'] Gene_or_gene_productt0e2: args2Role-mention-ngram: also binds directlytDe1: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] themetje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >nsubj [lemma='stat-1'] Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] theme:Gene_or_gene_producttprep_to [lemma='protein'] themetHe1: trigger-arg-path: binds >nsubj [lemma='stat-1'] Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] themetbe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: directly to thetJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] theme:Gene_or_gene_producttDe2: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] themet9e2: trigger-arg-path: binds >nsubj [lemma='stat-1'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >nsubj [lemma='stat-1'] themetSe1: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_to [lemma='protein'] theme:Gene_or_gene_producttprep_to [lemma='protein'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >nsubj [lemma='stat-1'] themetYe1: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='protein'] Gene_or_gene_producttYe2: trigger-arg-path: binds:Binding >prep_to [lemma='protein'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttPe2: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_to [lemma='protein'] Gene_or_gene_productt+e2: args2Role-mention-ngram: binds directlytde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='protein'] Gene_or_gene_producttQe2: trigger-arg-path: binds >prep_to [lemma='protein'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: binds directly totNe2: trigger-arg-path: binds >nsubj [lemma='stat-1'] theme:Gene_or_gene_producttHe2: trigger-arg-path: binds >nsubj [lemma='stat-1'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] themetMe2: trigger-arg-path: Binding >prep_to [lemma='protein'] Gene_or_gene_producttKe1: trigger-arg-path: binds >prep_to [lemma='protein'] Gene_or_gene_productt(e2: args2Role-mention-ngram: directly totQe1: trigger-arg-path: binds >prep_to [lemma='protein'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='stat-1'] themet-e2: ents2Label-mention-ngram: directly to thetKe2: trigger-arg-path: binds >prep_to [lemma='protein'] Gene_or_gene_productt,e1: args2Role-mention-ngram: directly to thetAe2: trigger-arg-path: binds:Binding >nsubj [lemma='stat-1'] themet9e1: trigger-arg-path: binds >nsubj [lemma='stat-1'] themetSe2: trigger-arg-path: Binding >prep_to [lemma='protein'] theme:Gene_or_gene_productt,interceding-token ngrams: and protein levelst'e1: ents2Label-mention-ngram: Ayurvedict1e2: ents2Label-mention-ngram: a berberine inducedt"e2: ents2Label-mention-ngram: ) bytAe1: trigger-arg-path: increased >nsubj controller:Simple_chemicalt0e1: args2Role-mention-ngram: a traditional plantt$interceding-token ngrams: transitiont.interceding-token ngrams: metastatic potentialtfe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Berberine'] controller:Simple_chemicaltVe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ampk'] controlledt'interceding-token ngrams: cell adhesiont/interceding-token ngrams: leading to inhibitiont!interceding-token ngrams: relatedt*e1: args2Role-mention-ngram: a traditionalt9e2: args2Role-mention-ngram: berberine induced CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: traditional plant alkaloidt$interceding-token ngrams: productiont)interceding-token ngrams: cell adhesion ,t$e2: args2Role-mention-ngram: ( COX-2t*interceding-token ngrams: ROS production ,t/interceding-token ngrams: potential of melanomatqe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ampk'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: strongly increased SHAREDt-interceding-token ngrams: inhibition of tumort!interceding-token ngrams: via ROSt%interceding-token ngrams: ) - relatedt$interceding-token ngrams: epithelialt*e1: args2Role-mention-ngram: antiprotozoaltinterceding-token ngrams: ( EMTt1interceding-token ngrams: Furthermore , berberinetre2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt(interceding-token ngrams: to mesenchymalt,interceding-token ngrams: via ROS productiontje1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='Berberine'] controllert~e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] Gene_or_gene_productt'e1: args2Role-mention-ngram: , stronglytje2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controller:Gene_or_gene_productt,interceding-token ngrams: and the expressiont'interceding-token ngrams: cells throught(e2: args2Role-mention-ngram: a berberinet1e1: args2Role-mention-ngram: , strongly increasedt+interceding-token ngrams: the expression oft$interceding-token ngrams: tumor cellt'interceding-token ngrams: of tumor celltOe1: trigger-arg-path: Positive_regulation >nsubj [lemma='Berberine'] controllertDe1: trigger-arg-path: increased:Positive_regulation >dobj controlledt!interceding-token ngrams: ( EMT )t2e1: ents2Label-mention-ngram: Chinese medicine fort-e1: ents2Label-mention-ngram: , a traditionalt*interceding-token ngrams: of epithelial tot'interceding-token ngrams: related genest-interceding-token ngrams: tumor cell adhesiontae2: trigger-arg-path: induced:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: Ayurvedic andtRe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj controller:Simple_chemicaltVe2: trigger-arg-path: induced:Positive_activation >nsubj >prep_of Gene_or_gene_productt.interceding-token ngrams: production , leadingt'interceding-token ngrams: inhibited thetIe1: trigger-arg-path: increased:Positive_regulation >dobj Phosphorylationt^e1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='Berberine'] Simple_chemicalt+e1: args2Role-mention-ngram: plant alkaloidt1e1: args2Role-mention-ngram: and Chinese medicinet1interceding-token ngrams: berberine inhibited thet-interceding-token ngrams: genes . Furthermoret2interceding-token ngrams: expression of epithelialt(interceding-token ngrams: the metastatict.e1: args2Role-mention-ngram: used in Ayurvedict$e2: args2Role-mention-ngram: COX-2 )t2e1: args2Role-mention-ngram: for its antimicrobialt[e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj Simple_chemicalt1e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL , atxe2: trigger-arg-path: induced >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: medicinet2interceding-token ngrams: the metastatic potentialt&interceding-token ngrams: transition (tce1: trigger-arg-path: increased:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt0interceding-token ngrams: mesenchymal transitiont/e1: ents2Label-mention-ngram: antimicrobial andt0e1: trigger-arg-path: increased >dobj controlledt2interceding-token ngrams: inhibited the metastatict&e2: args2Role-mention-ngram: berberinet2interceding-token ngrams: mesenchymal transition (t%interceding-token ngrams: , berberinet6e2: ents2Label-mention-ngram: berberine induced SHAREDt+e1: ents2Label-mention-ngram: antimicrobialt/e1: ents2Label-mention-ngram: traditional plantt)interceding-token ngrams: cells through at[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Berberine'] Simple_chemicalt'e1: args2Role-mention-ngram: propertiest!interceding-token ngrams: , tumort'e2: ents2Label-mention-ngram: berberinet'interceding-token ngrams: of epithelialtie1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='Berberine'] controller:Simple_chemicaltme2: trigger-arg-path: induced >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] Gene_or_gene_productt.e1: args2Role-mention-ngram: and antiprotozoalt3e1: ents2Label-mention-ngram: for its antimicrobialt&interceding-token ngrams: production ,t.e1: args2Role-mention-ngram: its antimicrobialt@e1: trigger-arg-path: increased >dobj controlled:Phosphorylationt)interceding-token ngrams: - related genest(interceding-token ngrams: the expressiont*e1: ents2Label-mention-ngram: in Ayurvedict?e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: Chinese medicine fort1e1: ents2Label-mention-ngram: plant alkaloid usedt(e1: ents2Label-mention-ngram: propertiest-interceding-token ngrams: berberine inhibitedt'interceding-token ngrams: expression oft)e1: args2Role-mention-ngram: properties ,tOe1: trigger-arg-path: increased >dobj [lemma='phosphorylation'] Phosphorylationt&e1: ents2Label-mention-ngram: medicinet0e2: args2Role-mention-ngram: a berberine inducedt^e1: trigger-arg-path: increased:Positive_regulation >dobj [lemma='phosphorylation'] controlledt1interceding-token ngrams: metastatic potential oft/e1: args2Role-mention-ngram: strongly increasedt(interceding-token ngrams: melanoma cellstZe1: trigger-arg-path: increased >dobj [lemma='phosphorylation'] controlled:Phosphorylationt%e1: ents2Label-mention-ngram: Chineset$e1: args2Role-mention-ngram: Chineset6e1: trigger-arg-path: increased >nsubj Simple_chemicalt9e1: args2Role-mention-ngram: and antiprotozoal propertiest"interceding-token ngrams: adhesiont.e1: ents2Label-mention-ngram: medicine for itstnsubj Simple_chemicalt,interceding-token ngrams: through a decreaset"interceding-token ngrams: of tumort)e1: ents2Label-mention-ngram: and Chineset=e1: ents2Label-mention-ngram: antimicrobial and antiprotozoalt"interceding-token ngrams: melanomatEe1: trigger-arg-path: increased >nsubj [lemma='Berberine'] controllert.e2: args2Role-mention-ngram: berberine inducedt*interceding-token ngrams: ERK activity andt3e1: ents2Label-mention-ngram: properties , stronglyt*interceding-token ngrams: transition ( EMTtLe2: trigger-arg-path: induced:Positive_activation >nsubj >prep_of controllert"e2: args2Role-mention-ngram: COX-2t$e1: args2Role-mention-ngram: used intbe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlledtJe1: trigger-arg-path: increased >nsubj [lemma='Berberine'] Simple_chemicaltUe1: trigger-arg-path: increased:Positive_regulation >nsubj controller:Simple_chemicalt.e1: ents2Label-mention-ngram: alkaloid used intwe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: Chinese medicinetoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='Berberine'] Simple_chemicalt*e1: ents2Label-mention-ngram: properties ,t*interceding-token ngrams: , tumor invasiont?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] Gene_or_gene_productt5e1: trigger-arg-path: increased >dobj Phosphorylationt+e1: ents2Label-mention-ngram: a traditionalt!e2: args2Role-mention-ngram: ) byt,e1: ents2Label-mention-ngram: plant alkaloidt#e2: ents2Label-mention-ngram: COX-2t!e1: args2Role-mention-ngram: usedt'interceding-token ngrams: epithelial tot0e1: ents2Label-mention-ngram: strongly increasedt2e1: args2Role-mention-ngram: properties , stronglytGe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj Simple_chemicaltTe1: trigger-arg-path: increased:Positive_regulation >dobj controlled:Phosphorylationt3interceding-token ngrams: to mesenchymal transitiontinterceding-token ngrams: EMT )t/e2: ents2Label-mention-ngram: berberine inducedt/e1: ents2Label-mention-ngram: used in Ayurvedictte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: ) by at+e1: ents2Label-mention-ngram: alkaloid usedt#e1: ents2Label-mention-ngram: plantt interceding-token ngrams: in ERKtJe1: trigger-arg-path: increased >dobj [lemma='phosphorylation'] controlledtze1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='Berberine'] controller:Simple_chemicaltne1: trigger-arg-path: increased:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: traditionaltinterceding-token ngrams: EMTt|e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ampk'] controlled:Gene_or_gene_productt.interceding-token ngrams: activity and proteint+e1: ents2Label-mention-ngram: antiprotozoalt(e1: args2Role-mention-ngram: and Chineset2e1: args2Role-mention-ngram: its antimicrobial andt1e1: ents2Label-mention-ngram: a traditional plantt#interceding-token ngrams: through at%e1: args2Role-mention-ngram: stronglyt&e1: args2Role-mention-ngram: Ayurvedict'interceding-token ngrams: to inhibitiont/interceding-token ngrams: , berberine inhibitedt/e1: ents2Label-mention-ngram: and antiprotozoalt(interceding-token ngrams: tumor invasiont(interceding-token ngrams: invasion , andt/e1: ents2Label-mention-ngram: its antimicrobialt&interceding-token ngrams: potential oft.e1: ents2Label-mention-ngram: in Ayurvedic andt`e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ampk'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Berberine'] controllertle2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] Gene_or_gene_productt*e1: args2Role-mention-ngram: antimicrobialt%e1: ents2Label-mention-ngram: used int%interceding-token ngrams: and proteint%interceding-token ngrams: of melanomat$interceding-token ngrams: invasion ,t:e1: ents2Label-mention-ngram: and antiprotozoal propertiest(interceding-token ngrams: ROS productiontwe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controllert2e1: args2Role-mention-ngram: Ayurvedic and Chineset-e1: args2Role-mention-ngram: alkaloid used intUe1: trigger-arg-path: increased >nsubj [lemma='Berberine'] controller:Simple_chemicalt)interceding-token ngrams: in ERK activityt+e1: ents2Label-mention-ngram: Ayurvedic andt)interceding-token ngrams: decrease in ERKt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlled:Gene_or_gene_productt%e1: args2Role-mention-ngram: alkaloidt3e1: ents2Label-mention-ngram: its antimicrobial andt&e1: ents2Label-mention-ngram: stronglytfe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controller:Simple_chemicalt+interceding-token ngrams: of melanoma cellst7e1: args2Role-mention-ngram: antiprotozoal properties ,t$interceding-token ngrams: metastatict3interceding-token ngrams: epithelial to mesenchymalt/e2: args2Role-mention-ngram: CONTROLLER ( COX-2t&e1: ents2Label-mention-ngram: alkaloidt6e1: ents2Label-mention-ngram: antiprotozoal propertiest%interceding-token ngrams: mesenchymalt*interceding-token ngrams: adhesion , tumort/e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL ,t3e1: ents2Label-mention-ngram: Ayurvedic and Chineset.e1: args2Role-mention-ngram: antimicrobial andt$interceding-token ngrams: adhesion ,t-e1: args2Role-mention-ngram: Chinese medicinet*interceding-token ngrams: to inhibition oft2e1: ents2Label-mention-ngram: and Chinese medicinetoe2: trigger-arg-path: Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controllertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='Berberine'] Simple_chemicalt,e1: args2Role-mention-ngram: , a traditionalt.e1: args2Role-mention-ngram: traditional plantt,e2: ents2Label-mention-ngram: by a berberinet'e2: args2Role-mention-ngram: COX-2 ) byt+e2: args2Role-mention-ngram: by a berberinet{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlledt%e2: ents2Label-mention-ngram: COX-2 )t#interceding-token ngrams: - relatedt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controller:Gene_or_gene_productt&interceding-token ngrams: ERK activityt&e2: args2Role-mention-ngram: ( COX-2 )t(e1: args2Role-mention-ngram: traditionaltge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of Gene_or_gene_productt:e1: args2Role-mention-ngram: strongly increased CONTROLLEDte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ampk'] controlled:Gene_or_gene_productt%e2: ents2Label-mention-ngram: ( COX-2tge2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ampk'] controlledt)e2: ents2Label-mention-ngram: a berberinet)interceding-token ngrams: related genes .t]e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of controllert!interceding-token ngrams: EMT ) -t*e1: args2Role-mention-ngram: alkaloid usedt+interceding-token ngrams: protein levels oft*e1: ents2Label-mention-ngram: medicine fort)e1: args2Role-mention-ngram: in Ayurvedict#interceding-token ngrams: potentialt8e1: ents2Label-mention-ngram: antiprotozoal properties ,t%e1: ents2Label-mention-ngram: for itst$e1: args2Role-mention-ngram: for itstinterceding-token ngrams: ROSt#e2: args2Role-mention-ngram: ) by at'e2: ents2Label-mention-ngram: ( COX-2 )tte2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controllertMinterceding-tokens-full-span: via ROS production , leading to inhibition of tumor cell adhesion , tumor invasion , and the expression of epithelial to mesenchymal transition ( EMT ) - related genes . Furthermore , berberine inhibited the metastatic potential of melanoma cells through a decrease in ERK activity and protein levels oft0interceding-token ngrams: melanoma cells throught(e2: ents2Label-mention-ngram: COX-2 ) byt"e1: ents2Label-mention-ngram: usedt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controllert(e1: ents2Label-mention-ngram: , stronglytke2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ampk'] controlled:Gene_or_gene_productt-e1: args2Role-mention-ngram: in Ayurvedic andtye2: trigger-arg-path: Positive_activation >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='Berberine'] controller:Simple_chemicaltce2: trigger-arg-path: induced >nsubj [lemma='level'] >prep_of [lemma='cyclooxygenase-2'] controllertYe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='Berberine'] controllert5e1: args2Role-mention-ngram: antiprotozoal propertiest7e1: args2Role-mention-ngram: traditional plant alkaloidt2e1: ents2Label-mention-ngram: , strongly increasedt interceding-token ngrams: , Rhebt%interceding-token ngrams: . Upon PI3Kt interceding-token ngrams: Rheb .tEe1: trigger-arg-path: Binding >nn [lemma='tsc2'] Gene_or_gene_productt0interceding-token ngrams: mTORC1 by inactivatingt-interceding-token ngrams: inactivating mTORC1t#interceding-token ngrams: protein ,tHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] themet.interceding-token ngrams: Upon PI3K activationtinterceding-token ngrams: Rhebtzinterceding-tokens-full-span: suppresses mTORC1 by inactivating mTORC1 interacting protein , Rheb . Upon PI3K activation ,t6e1: trigger-arg-path: complex >nn [lemma='tsc2'] themet%interceding-token ngrams: Rheb . Upont9interceding-token ngrams: inactivating mTORC1 interactingtKe1: trigger-arg-path: complex >nn [lemma='tsc2'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] themetKe1: trigger-arg-path: Binding >nn [lemma='tsc2'] theme:Gene_or_gene_productt%interceding-token ngrams: interactingt&interceding-token ngrams: inactivatingt.interceding-token ngrams: suppresses mTORC1 byt-interceding-token ngrams: interacting proteint)interceding-token ngrams: by inactivatingt#interceding-token ngrams: mTORC1 byt+interceding-token ngrams: suppresses mTORC1t+interceding-token ngrams: PI3K activation ,t4interceding-token ngrams: mTORC1 interacting proteint)interceding-token ngrams: PI3K activationtinterceding-token ngrams: PI3Ktee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] theme:Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] themet"interceding-token ngrams: , Rheb .t_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='tsc2'] Gene_or_gene_productt,interceding-token ngrams: mTORC1 interactingt]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] theme:Gene_or_gene_producttEe1: trigger-arg-path: complex >nn [lemma='tsc2'] Gene_or_gene_productt/interceding-token ngrams: interacting protein ,t#interceding-token ngrams: Upon PI3KtWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='tsc2'] Gene_or_gene_productt(interceding-token ngrams: protein , Rhebt0interceding-token ngrams: by inactivating mTORC1t6e1: trigger-arg-path: Binding >nn [lemma='tsc2'] themetMe1: trigger-arg-path: complex:Binding >nn [lemma='tsc2'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=promote nn Phosphorylationt$e2: args2Role-mention-ngram: wt , ort|e2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] controlled:Phosphorylationt[e2: trigger-arg-path: promoted nn [lemma='erk'] controlledt'e2: args2Role-mention-ngram: HeLa cellst$e2: args2Role-mention-ngram: in HeLat3e2: trigger-arg-path: promoted nn controlledtPe2: trigger-arg-path: promoted:Positive_regulation conj_or >nn controllert2e2: ents2Label-mention-ngram: cells overexpressingt{e1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='erk'] controlled:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] Phosphorylationtae2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn controllert]e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn Phosphorylationtbe2: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn controller:Gene_or_gene_productt:e2: ents2Label-mention-ngram: cells overexpressing HA-ERK2t&interceding-token ngrams: this purposetWe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn controlledt9e2: ents2Label-mention-ngram: phosphorylation promoted byt+e2: ents2Label-mention-ngram: in HeLa cellstCe2: trigger-arg-path: Positive_regulation nn Phosphorylationt!interceding-token ngrams: ) . Fort%interceding-token ngrams: and 15d-PGJt8e2: ents2Label-mention-ngram: overexpressing HA-ERK2 andt.e2: args2Role-mention-ngram: promoted by thesetnn Gene_or_gene_producttPe1: trigger-arg-path: induced:Positive_activation nn Gene_or_gene_productt=e1: ents2Label-mention-ngram: induced by GENE_OR_GENE_PRODUCTt(e2: ents2Label-mention-ngram: HeLa cellst$e2: ents2Label-mention-ngram: cyP int?e2: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert%e2: args2Role-mention-ngram: by theset*e2: ents2Label-mention-ngram: by these cyPt3e2: args2Role-mention-ngram: overexpressing HA-ERK2t,e2: args2Role-mention-ngram: , or CONTROLLERtze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='erk'] controlledtle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='cyp'] Gene_or_gene_producttfe1: trigger-arg-path: induced:Positive_activation >agent [lemma='cyp'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='cyp'] Gene_or_gene_producttke2: trigger-arg-path: Positive_regulation nn [lemma='erk'] Phosphorylationt!e2: ents2Label-mention-ngram: cyPtRe1: trigger-arg-path: induced >agent [lemma='cyp'] controller:Gene_or_gene_productt&interceding-token ngrams: purpose , wet?e2: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: cyP intMe2: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn controllertve1: trigger-arg-path: Positive_activation nn [lemma='erk'] controlled:Gene_or_gene_productt7e2: args2Role-mention-ngram: overexpressing HA-ERK2 andt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] controlledt3e1: ents2Label-mention-ngram: activation induced byt6e2: args2Role-mention-ngram: HeLa cells overexpressingt(e2: ents2Label-mention-ngram: AU5-hSpry2tinterceding-token ngrams: PGA 1t+e2: ents2Label-mention-ngram: AU5-hSpry2 wttUe1: trigger-arg-path: induced nn [lemma='erk'] controlledtinterceding-token ngrams: 2 ) .t*e2: args2Role-mention-ngram: or CONTROLLERtQe2: trigger-arg-path: Positive_regulation conj_or >nn Gene_or_gene_productt/e2: ents2Label-mention-ngram: promoted by thesetGe2: trigger-arg-path: Positive_regulation conj_or >nn controllert^e1: trigger-arg-path: Positive_activation >agent [lemma='cyp'] controller:Gene_or_gene_productt|e2: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert)e2: ents2Label-mention-ngram: cyP in HeLat&e2: ents2Label-mention-ngram: by theset~e1: trigger-arg-path: induced:Positive_activation nn [lemma='erk'] controlled:Gene_or_gene_productt"interceding-token ngrams: For thist'e2: args2Role-mention-ngram: AU5-hSpry2t2e1: args2Role-mention-ngram: activation induced bytGe1: trigger-arg-path: induced nn controlled:Gene_or_gene_producttoe2: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllertXe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='cyp'] controller:Gene_or_gene_producttVinterceding-tokens-full-span: ( PGA 1 and 15d-PGJ 2 ) . For this purpose , we measuredtje1: trigger-arg-path: induced nn [lemma='erk'] controlled:Gene_or_gene_productt#interceding-token ngrams: 15d-PGJ 2t*e2: ents2Label-mention-ngram: these cyP int)e2: ents2Label-mention-ngram: HA-ERK2 andt)e2: args2Role-mention-ngram: by these cyPtae1: trigger-arg-path: Positive_activation nn [lemma='erk'] controlledt%interceding-token ngrams: 15d-PGJ 2 )t!e2: args2Role-mention-ngram: wt ,tWe2: trigger-arg-path: promoted:Positive_regulation nn controlled:Phosphorylationt#interceding-token ngrams: purpose ,tle2: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] controlledt7CSSPATH: ROOT >ccomp >prep_of >vmod ++ ROOT >dobj >vmodt*interceding-token ngrams: For this purposet>e1: trigger-arg-path: Positive_activation nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='erk'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] controlled:Phosphorylationt5e2: ents2Label-mention-ngram: or GENE_OR_GENE_PRODUCTtSe1: trigger-arg-path: Positive_activation >agent [lemma='cyp'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: overexpressingt7e2: ents2Label-mention-ngram: , or GENE_OR_GENE_PRODUCTtIe1: trigger-arg-path: Positive_activation >agent [lemma='cyp'] controllertFe1: trigger-arg-path: induced:Positive_activation nn controlledt?e2: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: HA-ERK2 and AU5-hSpry2t[e1: trigger-arg-path: induced:Positive_activation >agent [lemma='cyp'] Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=induce nn controlledt?e2: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert+e2: args2Role-mention-ngram: overexpressingt%interceding-token ngrams: we measuredt?e2: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllertHe1: trigger-arg-path: Positive_activation nn Gene_or_gene_productt(interceding-token ngrams: this purpose ,t!e2: args2Role-mention-ngram: , ort!e2: args2Role-mention-ngram: HeLat9e2: args2Role-mention-ngram: cells overexpressing HA-ERK2tinterceding-token ngrams: PGAt7e2: ents2Label-mention-ngram: HeLa cells overexpressingtQe2: trigger-arg-path: promoted conj_or >nn controller:Gene_or_gene_productt>e2: trigger-arg-path: Positive_regulation nn controlledt8e2: trigger-arg-path: promoted nn Phosphorylationt#interceding-token ngrams: PGA 1 andtie1: trigger-arg-path: induced:Positive_activation nn [lemma='erk'] controlledtQe1: trigger-arg-path: induced:Positive_activation >agent [lemma='cyp'] controllertXe1: trigger-arg-path: lemmatizedTrigger=induce nn controlled:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controlled:Phosphorylationt2e1: args2Role-mention-ngram: CONTROLLED activationt?e2: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt"interceding-token ngrams: measuredt(e2: args2Role-mention-ngram: cyP in HeLat'interceding-token ngrams: 1 and 15d-PGJt e2: args2Role-mention-ngram: cyPtFe2: trigger-arg-path: promoted conj_or >nn Gene_or_gene_productt2e1: trigger-arg-path: induced nn controlledtke1: trigger-arg-path: Positive_activation nn [lemma='erk'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn controlled:Gene_or_gene_productt)e2: args2Role-mention-ngram: these cyP intGe2: trigger-arg-path: promoted:Positive_regulation nn controlledt'interceding-token ngrams: , we measuredt4e2: ents2Label-mention-ngram: overexpressing HA-ERK2tke2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn Gene_or_gene_producttfe2: trigger-arg-path: Positive_regulation nn [lemma='erk'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: these cyPtbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >agent [lemma='cyp'] controllert\e2: trigger-arg-path: Positive_regulation conj_or >nn controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: in HeLat(e2: args2Role-mention-ngram: HA-ERK2 andt?e2: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: AU5-hSpry2 wt ,tae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='erk'] controlledtce1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='cyp'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylation promotedtte2: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] Phosphorylationtpe1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='erk'] Gene_or_gene_productt/e1: args2Role-mention-ngram: activation inducedtNe2: trigger-arg-path: Positive_regulation nn controlled:Phosphorylationt?e2: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt3e2: args2Role-mention-ngram: HA-ERK2 and AU5-hSpry2tve2: trigger-arg-path: Positive_regulation nn [lemma='erk'] controlled:Phosphorylationt.e2: args2Role-mention-ngram: and AU5-hSpry2 wtt1e2: args2Role-mention-ngram: cells overexpressingtinterceding-token ngrams: . Fort_e1: trigger-arg-path: induced nn [lemma='erk'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: HA-ERK2t=e2: ents2Label-mention-ngram: SHARED phosphorylation promotedt!interceding-token ngrams: ( PGA 1tDe2: trigger-arg-path: lemmatizedTrigger=promote nn controlledt!interceding-token ngrams: purposetinterceding-token ngrams: ( PGAt?e2: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] Phosphorylationtve2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: AU5-hSpry2 wt ,t%e2: ents2Label-mention-ngram: wt , ort&e2: args2Role-mention-ngram: these cyPt`e2: trigger-arg-path: promoted nn [lemma='erk'] Phosphorylationt"e2: ents2Label-mention-ngram: wt ,tWe2: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn Gene_or_gene_productt!interceding-token ngrams: 15d-PGJtMe1: trigger-arg-path: lemmatizedTrigger=induce nn Gene_or_gene_producttZe2: trigger-arg-path: promoted:Positive_regulation conj_or >nn Gene_or_gene_productt=e1: trigger-arg-path: induced >agent [lemma='cyp'] controllertinterceding-token ngrams: FortGe1: trigger-arg-path: induced >agent [lemma='cyp'] Gene_or_gene_producttconj_or >nn controllertNe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='cyp'] controllertCe2: trigger-arg-path: promoted nn controlled:Phosphorylationt[e1: trigger-arg-path: induced:Positive_activation nn controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: in HeLa cellst?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nn [lemma='erk'] Gene_or_gene_productt*e2: args2Role-mention-ngram: AU5-hSpry2 wttke2: trigger-arg-path: promoted nn [lemma='erk'] controlled:PhosphorylationtSe1: trigger-arg-path: Positive_activation nn controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: activation inducedtse1: trigger-arg-path: induced:Positive_activation nn [lemma='erk'] Gene_or_gene_productt'interceding-token ngrams: and 15d-PGJ 2te2: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] controlled:PhosphorylationtLe2: trigger-arg-path: promoted:Positive_regulation nn Phosphorylationt$e2: args2Role-mention-ngram: HA-ERK2t7e1: ents2Label-mention-ngram: SHARED activation inducedt,e2: ents2Label-mention-ngram: and AU5-hSpry2t"e2: ents2Label-mention-ngram: , ortee2: trigger-arg-path: promoted:Positive_regulation conj_or >nn controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: HeLat$interceding-token ngrams: . For thist/e2: ents2Label-mention-ngram: and AU5-hSpry2 wtt+e2: args2Role-mention-ngram: and AU5-hSpry2t?e2: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt:e1: args2Role-mention-ngram: CONTROLLED activation inducedtTe2: trigger-arg-path: lemmatizedTrigger=promote nn controlled:Phosphorylationt;e1: ents2Label-mention-ngram: HIF-1alpha and GENERIC_ENTITYt'e1: ents2Label-mention-ngram: protein ,tinterceding-token ngrams: lacktoe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] Simple_chemicaltme2: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controllert"interceding-token ngrams: The lacktTe1: trigger-arg-path: promotes nn [lemma='vhl'] controllert/e2: ents2Label-mention-ngram: the hydroxylationt]e2: trigger-arg-path: prevents:Negative_regulation >nsubj >prep_of controller:Simple_chemicalt4e2: args2Role-mention-ngram: prevents the CONTROLLEDtIe2: trigger-arg-path: Negative_regulation >nsubj >prep_of Simple_chemicalt/e1: ents2Label-mention-ngram: of HIF-1alpha andt1e1: args2Role-mention-ngram: CONTROLLER protein ,t,e1: args2Role-mention-ngram: protein , whichtYe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controllert.e2: ents2Label-mention-ngram: hydroxylation oft,e1: ents2Label-mention-ngram: which promotest?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controller:Simple_chemicalt=e1: ents2Label-mention-ngram: promotes the polyubiquitinationt4e1: trigger-arg-path: promotes nn controllert?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] Gene_or_gene_productt4e2: args2Role-mention-ngram: CONTROLLER prevents thetre2: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] Simple_chemicaltOe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of Simple_chemicalt*e2: ents2Label-mention-ngram: prevents thet/e1: args2Role-mention-ngram: which promotes thetCe2: ents2Label-mention-ngram: hydroxylation of GENE_OR_GENE_PRODUCTtie1: trigger-arg-path: Positive_regulation nn [lemma='vhl'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: polyubiquitination oft%interceding-token ngrams: The lack oft+interceding-token ngrams: degradation . Thet>e1: trigger-arg-path: promotes nn Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controller:Simple_chemicalt_e1: trigger-arg-path: Positive_regulation nn [lemma='vhl'] controllert0e1: ents2Label-mention-ngram: and GENERIC_ENTITYt9e2: trigger-arg-path: prevents >nsubj >prep_of controllert}e2: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controller:Simple_chemicaltoe1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=promote nn controller:Gene_or_gene_producttie2: trigger-arg-path: prevents >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controller:Simple_chemicaltRe1: trigger-arg-path: promotes:Positive_regulation nn Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] controllert&CSSPATH: ROOT >prep_to >rcmod ++ ROOT tce1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >prep_of controller:Simple_chemicalt.e1: ents2Label-mention-ngram: , which promotestnn [lemma='vhl'] controller:Gene_or_gene_productt}e1: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: HIF-1alpha andtIe1: trigger-arg-path: Positive_regulation nn Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controllertie2: trigger-arg-path: Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] Simple_chemicalt-e1: ents2Label-mention-ngram: protein , whicht/e1: args2Role-mention-ngram: CONTROLLER proteint$interceding-token ngrams: . The lackt7e1: ents2Label-mention-ngram: the polyubiquitination oft(e1: ents2Label-mention-ngram: HIF-1alphatje2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controllertie1: trigger-arg-path: promotes nn [lemma='vhl'] controller:Gene_or_gene_producttMe2: trigger-arg-path: prevents:Negative_regulation >nsubj >prep_of controllert)e2: args2Role-mention-ngram: prevents thetEe1: trigger-arg-path: lemmatizedTrigger=promote nn controllertne1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: the hydroxylation oft>e1: ents2Label-mention-ngram: polyubiquitination of HIF-1alphatye1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] controllertOe1: trigger-arg-path: lemmatizedTrigger=promote nn Gene_or_gene_productt^e1: trigger-arg-path: promotes nn [lemma='vhl'] Gene_or_gene_producttHe1: trigger-arg-path: promotes:Positive_regulation nn controllert7interceding-tokens-full-span: degradation . The lack oftYe2: trigger-arg-path: prevents >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controllertde2: trigger-arg-path: Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controllertTe2: trigger-arg-path: Negative_regulation >nsubj >prep_of controller:Simple_chemicalt+e1: ents2Label-mention-ngram: of HIF-1alphat-e1: args2Role-mention-ngram: , which promotest:e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL prevents thetZe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of controller:Simple_chemicalt?e1: trigger-arg-path: Positive_regulation nn controllert!interceding-token ngrams: lack oftte2: trigger-arg-path: Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] controller:Simple_chemicalt6e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL preventstIe1: trigger-arg-path: promotes nn controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: which promotesthe1: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] controllert>e2: trigger-arg-path: prevents >nsubj >prep_of Simple_chemicalt^e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >prep_of controllertze1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='vhl'] controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_regulation nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='vhl'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] Simple_chemicalt&e1: args2Role-mention-ngram: protein ,t+e2: ents2Label-mention-ngram: hydroxylationt8e2: ents2Label-mention-ngram: prevents the hydroxylationt]e1: trigger-arg-path: promotes:Positive_regulation nn controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj >prep_of Simple_chemicaltre1: trigger-arg-path: promotes:Positive_regulation nn [lemma='vhl'] Gene_or_gene_productt^e2: trigger-arg-path: prevents >nsubj [lemma='lack'] >prep_of [lemma='oxygen'] Simple_chemicaltRe2: trigger-arg-path: prevents:Negative_regulation >nsubj >prep_of Simple_chemicalt0e2: args2Role-mention-ngram: CONTROLLER preventstIe2: trigger-arg-path: prevents >nsubj >prep_of controller:Simple_chemicalt?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitet]e2: trigger-arg-path: binding:Binding prep_to >nn theme:Gene_or_gene_producttUe2: trigger-arg-path: binding:Binding prep_to >prep_in >nn site:Sitetbe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn sitet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitet@e2: trigger-arg-path: binding prep_to >nn themet-e1: ents2Label-mention-ngram: SHARED promotertie1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt@e1: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] themet@e1: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] themet)e2: ents2Label-mention-ngram: promoter intMe2: trigger-arg-path: Binding prep_to >prep_in >nn site:SitetHe1: trigger-arg-path: Binding prep_to >prep_in >nn SitetOe1: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_producttOe1: trigger-arg-path: binding prep_to >nn Gene_or_gene_producttOe2: trigger-arg-path: Binding prep_to >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: promoter intbe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn SitetOe2: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: in SITEtMe1: trigger-arg-path: Binding prep_to >prep_in >nn site:SitetHe2: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] themet?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitet@e2: trigger-arg-path: Binding prep_to >nn themet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themetbe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn Sitet?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn sitet0e1: ents2Label-mention-ngram: SHARED promoter intRe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn themet?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet+e1: args2Role-mention-ngram: THEME promotertoe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitetie2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn Gene_or_gene_productt.e1: ents2Label-mention-ngram: promoter in A549t?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitetie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] themet.e2: args2Role-mention-ngram: THEME promoter intHe2: trigger-arg-path: binding prep_to >prep_in >nn sitetge2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitetae1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitet?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] SitetUe1: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn site:SitetWe1: trigger-arg-path: binding:Binding prep_to >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitetae1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt@e1: trigger-arg-path: binding prep_to >nn themetae2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn Gene_or_gene_producttOe2: trigger-arg-path: binding prep_to >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitet@e1: trigger-arg-path: Binding prep_to >nn themetOe1: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt.e1: args2Role-mention-ngram: to THEME promotert)e1: ents2Label-mention-ngram: promoter intHe2: trigger-arg-path: binding:Binding prep_to >nn themetOe2: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themetHe1: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] themet?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitet?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitetae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt$e2: args2Role-mention-ngram: in SITEtUe2: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt]e1: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_producttWe1: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet0e2: ents2Label-mention-ngram: SHARED promoter int?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] SitetHe2: trigger-arg-path: binding prep_to >prep_in >nn Sitet?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themetge2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn site:SitetZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn themetUe2: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] SitetZe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn sitet?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binding prep_to >prep_in >nn sitet?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themetPe2: trigger-arg-path: binding:Binding prep_to >prep_in >nn sitet?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitetge1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn site:Sitet%e2: ents2Label-mention-ngram: in A549t]e2: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] themet(e1: args2Role-mention-ngram: promoter intPe1: trigger-arg-path: binding:Binding prep_to >prep_in >nn sitetZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nf-kappab'] themetZe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn Sitet-e2: args2Role-mention-ngram: promoter in SITEt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitet_e1: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn site:SitetZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn themet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitetoe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_producttHe2: trigger-arg-path: Binding prep_to >prep_in >nn sitet0e1: ents2Label-mention-ngram: to SHARED promotertHe1: trigger-arg-path: binding:Binding prep_to >nn themet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitetUe1: trigger-arg-path: binding prep_to >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet"e1: ents2Label-mention-ngram: A549tZe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >prep_in >nn SitetPe2: trigger-arg-path: binding:Binding prep_to >prep_in >nn Sitet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet.e1: args2Role-mention-ngram: THEME promoter intHe1: trigger-arg-path: binding prep_to >prep_in >nn Sitet?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:SitetPe1: trigger-arg-path: binding:Binding prep_to >prep_in >nn Sitetoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn theme:Gene_or_gene_productt@e2: trigger-arg-path: binding >prep_of [lemma='nf-kappab'] themetMe1: trigger-arg-path: binding prep_to >prep_in >nn site:Sitet?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] Sitet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet]e1: trigger-arg-path: binding:Binding prep_to >nn theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding prep_to >nn theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: promotertOe1: trigger-arg-path: Binding prep_to >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themetHe2: trigger-arg-path: Binding prep_to >prep_in >nn Sitet?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] SitetUe2: trigger-arg-path: binding prep_to >nn theme:Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitetge2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn themetWe2: trigger-arg-path: binding:Binding prep_to >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttUe1: trigger-arg-path: binding:Binding prep_to >prep_in >nn site:Sitet%e1: ents2Label-mention-ngram: in A549tHe1: trigger-arg-path: Binding prep_to >prep_in >nn sitet0e2: ents2Label-mention-ngram: to SHARED promotertMe2: trigger-arg-path: binding prep_to >prep_in >nn site:Sitet&e1: ents2Label-mention-ngram: promotertWe2: trigger-arg-path: binding:Binding >prep_of [lemma='nf-kappab'] Gene_or_gene_productt.e2: args2Role-mention-ngram: to THEME promotert+e2: args2Role-mention-ngram: THEME promotert-e1: args2Role-mention-ngram: promoter in SITEt"e2: ents2Label-mention-ngram: A549t?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] sitet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productte1: SITE: 5tUe2: trigger-arg-path: Binding prep_to >nn theme:Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_of [lemma='nf-kappab'] themetie1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >prep_in [lemma='cell'] >nn [lemma='a549'] site:Sitet?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet.e2: ents2Label-mention-ngram: promoter in A549tbe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >prep_in >nn sitetRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nf-kappab'] themet?e1: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt-interceding-token ngrams: proteins in pan-RastRe2: trigger-arg-path: reduced >nsubj [lemma='peroxide'] controller:Simple_chemicaltce1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] controller:Simple_chemicalt0e1: ents2Label-mention-ngram: might specificallyt%interceding-token ngrams: analysis oftSe1: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicaltpe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt3e1: trigger-arg-path: reduce >nsubj Simple_chemicalt?interceding-tokens-full-span: , as suggested by immunoblot analysis of ubiquitinated proteins in pan-Ras immunoprecipitates . shows thattce2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] controller:Simple_chemicalt'interceding-token ngrams: ubiquitinatedt7e1: ents2Label-mention-ngram: SHARED might specificallyt!interceding-token ngrams: . showstwe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj controlled:Ubiquitinationt[e2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicalt.interceding-token ngrams: immunoprecipitates .tVe2: trigger-arg-path: reduced >dobj [lemma='ubiquitination'] controlled:UbiquitinationtUe1: trigger-arg-path: reduce:Negative_regulation >nsubj [lemma='peroxide'] controllertXe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] Simple_chemicalt0interceding-token ngrams: immunoblot analysis oftGe1: trigger-arg-path: reduce:Negative_regulation >nsubj Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] controllertSe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj controlledt-interceding-token ngrams: immunoblot analysistXe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj controllertle2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicalt,interceding-token ngrams: immunoprecipitatest.e1: args2Role-mention-ngram: reduce CONTROLLEDt^e2: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltWe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj UbiquitinationtSe2: trigger-arg-path: reduced:Negative_regulation >nsubj controller:Simple_chemicaltCe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj Ubiquitinationt:e2: args2Role-mention-ngram: CONTROLLER reduced CONTROLLEDtVe2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='peroxide'] controllertHe2: trigger-arg-path: reduced:Negative_regulation >nsubj Simple_chemicalte1: trigger: reducet7interceding-token ngrams: in pan-Ras immunoprecipitatest@e1: ents2Label-mention-ngram: specifically reduce ubiquitinationt3e1: ents2Label-mention-ngram: reduce ubiquitinationt6interceding-token ngrams: pan-Ras immunoprecipitates .tinterceding-token ngrams: showst$interceding-token ngrams: immunoblott$interceding-token ngrams: in pan-RastSe2: trigger-arg-path: Negative_regulation >dobj [lemma='ubiquitination'] controlledtRe1: trigger-arg-path: reduce:Negative_regulation >nsubj controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj controlledt3interceding-token ngrams: analysis of ubiquitinatedt1e1: ents2Label-mention-ngram: specifically reducet6e1: args2Role-mention-ngram: might specifically reducetEe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj Simple_chemicaltTe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj controllertQe1: trigger-arg-path: reduce >nsubj [lemma='peroxide'] controller:Simple_chemicalt:e1: args2Role-mention-ngram: CONTROLLER might specificallytCe2: trigger-arg-path: reduced:Negative_regulation >nsubj controllert.e1: trigger-arg-path: reduce >nsubj controllertle1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicaltWe2: trigger-arg-path: Negative_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt{e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt4e2: trigger-arg-path: reduced >nsubj Simple_chemicaltbe2: trigger-arg-path: Negative_regulation >dobj [lemma='ubiquitination'] controlled:UbiquitinationtPe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controller:Simple_chemicalt6e1: ents2Label-mention-ngram: reduce ubiquitination oftQe2: trigger-arg-path: reduced:Negative_regulation >dobj controlled:Ubiquitinationtje2: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt.e2: trigger-arg-path: reduced >dobj controlledtGe2: trigger-arg-path: reduced >dobj [lemma='ubiquitination'] controlledtFe2: trigger-arg-path: reduced:Negative_regulation >dobj UbiquitinationtPe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controller:Simple_chemicalt^e1: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltYe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj Simple_chemicaltde2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj controller:Simple_chemicaltIe2: trigger-arg-path: Negative_regulation >dobj controlled:Ubiquitinationt$e1: ents2Label-mention-ngram: reducet>e2: trigger-arg-path: Negative_regulation >dobj Ubiquitinationt)interceding-token ngrams: as suggested byt&interceding-token ngrams: as suggestedt2e2: trigger-arg-path: reduced >dobj UbiquitinationtSe2: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicalt*interceding-token ngrams: of ubiquitinatedtZe1: trigger-arg-path: reduce:Negative_regulation >nsubj [lemma='peroxide'] Simple_chemicalt0e1: args2Role-mention-ngram: specifically reducetge2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt_e2: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt;e1: args2Role-mention-ngram: specifically reduce CONTROLLEDtBe1: trigger-arg-path: reduce:Negative_regulation >nsubj controllertKe2: trigger-arg-path: reduced >dobj [lemma='ubiquitination'] UbiquitinationtSe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='peroxide'] controllert,e2: ents2Label-mention-ngram: SHARED reducedtge2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] controllertGe2: trigger-arg-path: reduced >nsubj [lemma='peroxide'] Simple_chemicaltfe2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltNe1: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] controllert'interceding-token ngrams: by immunoblottde1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj controller:Simple_chemicaltYe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj Simple_chemicalt;e2: ents2Label-mention-ngram: reduced SHARED ubiquitinationt0interceding-token ngrams: ubiquitinated proteinst3e2: ents2Label-mention-ngram: SHARED reduced SHAREDtBe2: trigger-arg-path: reduced:Negative_regulation >dobj controlledt3interceding-token ngrams: ubiquitinated proteins int?e2: trigger-arg-path: reduced >nsubj controller:Simple_chemicaltee1: trigger-arg-path: reduce:Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicalt&interceding-token ngrams: . shows thattEe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj Simple_chemicalt/e1: args2Role-mention-ngram: might specificallyt=e2: trigger-arg-path: reduced >dobj controlled:Ubiquitinationt!interceding-token ngrams: pan-Rastge1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] controllert>e1: trigger-arg-path: reduce >nsubj controller:Simple_chemicaltbe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj controlled:Ubiquitinationtwe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicalt#e1: args2Role-mention-ngram: reducet*e1: ents2Label-mention-ngram: SHARED mightt[e2: trigger-arg-path: reduced:Negative_regulation >dobj [lemma='ubiquitination'] controlledtNe2: trigger-arg-path: Negative_regulation >nsubj [lemma='peroxide'] controllert(interceding-token ngrams: , as suggestedtXe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='ubiquitination'] controlledt$interceding-token ngrams: shows thattFe1: trigger-arg-path: reduce >nsubj [lemma='peroxide'] Simple_chemicalt4interceding-token ngrams: immunoprecipitates . showst7e1: ents2Label-mention-ngram: might specifically reducet0interceding-token ngrams: by immunoblot analysistBe2: trigger-arg-path: reduced >nsubj [lemma='peroxide'] controllertle2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='ubiquitination'] controlledt/e2: args2Role-mention-ngram: CONTROLLER reducedt&interceding-token ngrams: suggested byt4interceding-token ngrams: pan-Ras immunoprecipitatest1interceding-token ngrams: suggested by immunoblottAe1: trigger-arg-path: reduce >nsubj [lemma='peroxide'] controllert3interceding-token ngrams: of ubiquitinated proteinst\e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='ubiquitination'] Ubiquitinationtce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='PLX'] controllertSe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='plx7904'] controllert=e1-label: Negative_activation + e2-label: Negative_regulationt interceding-token ngrams: BRAF .t&interceding-token ngrams: 2 activationtBe1: trigger-arg-path: inhibits >nsubj [lemma='plx7904'] controllert)interceding-token ngrams: 2 activation int2e2: ents2Label-mention-ngram: inhibited SHARED andt$interceding-token ngrams: but not int+e2: args2Role-mention-ngram: 7904 inhibitedt^e2: trigger-arg-path: Negative_regulation >nsubj [lemma='PLX'] controller:Gene_or_gene_producttge1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_productt%interceding-token ngrams: Promisinglyt3e2: ents2Label-mention-ngram: 7904 inhibited SHAREDtVe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='plx7904'] controllert,e2: ents2Label-mention-ngram: 7904 inhibitedt+interceding-token ngrams: cells with mutanttxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_producttHe1: trigger-arg-path: inhibits >dobj [lemma='erk1'] Gene_or_gene_productt\e1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='erk1'] Gene_or_gene_productt'interceding-token ngrams: . Promisinglythe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='plx7904'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: inhibited SHAREDtSe1: trigger-arg-path: Negative_activation >dobj [lemma='erk1'] Gene_or_gene_producttSe1: trigger-arg-path: inhibits >dobj [lemma='erk1'] controlled:Gene_or_gene_producttSe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='PLX'] controllertme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='PLX'] Gene_or_gene_productt^e1: trigger-arg-path: Negative_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_productt!e2: args2Role-mention-ngram: 7904t7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 7904t3e2: ents2Label-mention-ngram: and 2 phosphorylationt(interceding-token ngrams: with wild-typetWe1: trigger-arg-path: inhibits >nsubj [lemma='plx7904'] controller:Gene_or_gene_producttinterceding-token ngrams: BRAFt$interceding-token ngrams: BRAF , butt)interceding-token ngrams: . Promisingly ,t`e1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='plx7904'] Gene_or_gene_productt'interceding-token ngrams: in cells witht]e2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='PLX'] Gene_or_gene_productthe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='PLX'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Negative_regulation >nsubj [lemma='PLX'] controllertSe2: trigger-arg-path: Negative_regulation >nsubj [lemma='PLX'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='PLX'] controllert#e2: ents2Label-mention-ngram: and 2tqe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='plx7904'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 7904 inhibitedtLe1: trigger-arg-path: inhibits >nsubj [lemma='plx7904'] Gene_or_gene_productt'interceding-token ngrams: mutant BRAF ,tIe1: trigger-arg-path: Negative_activation >dobj [lemma='erk1'] controlledtWe1: trigger-arg-path: Negative_activation >nsubj [lemma='plx7904'] Gene_or_gene_productt'interceding-token ngrams: Promisingly ,tinterceding-tokens-full-span: and 2 activation in cells with mutant BRAF , but not in cells with wild-type BRAF . Promisingly ,tIe2: trigger-arg-path: inhibited >nsubj [lemma='PLX'] Gene_or_gene_productt>e1: trigger-arg-path: inhibits >dobj [lemma='erk1'] controlledtce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='erk1'] controlledt?e2: trigger-arg-path: inhibited >nsubj [lemma='PLX'] controllertTe2: trigger-arg-path: inhibited >nsubj [lemma='PLX'] controller:Gene_or_gene_productt%interceding-token ngrams: mutant BRAFtde1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='erk1'] controlled:Gene_or_gene_productt%interceding-token ngrams: with mutanttke1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='plx7904'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='erk1'] Gene_or_gene_productt,interceding-token ngrams: BRAF . Promisinglytme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='erk1'] Gene_or_gene_productt-interceding-token ngrams: with wild-type BRAFt6e2: args2Role-mention-ngram: CONTROLLER 7904 inhibitedt/e2: ents2Label-mention-ngram: 2 phosphorylationt"e2: ents2Label-mention-ngram: 7904t*e2: ents2Label-mention-ngram: SHARED and 2t(interceding-token ngrams: wild-type BRAFt.interceding-token ngrams: cells with wild-typetbe1: trigger-arg-path: Negative_activation >nsubj [lemma='plx7904'] controller:Gene_or_gene_productt6e2: args2Role-mention-ngram: 7904 inhibited CONTROLLEDt-interceding-token ngrams: activation in cellst]e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='plx7904'] Gene_or_gene_producttMe1: trigger-arg-path: Negative_activation >nsubj [lemma='plx7904'] controllert interceding-token ngrams: not int*interceding-token ngrams: with mutant BRAFt interceding-token ngrams: BRAF ,txe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='PLX'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: CONTROLLER 7904tOe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='erk1'] controlledt*interceding-token ngrams: and 2 activationtge1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='plx7904'] controllertYe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='PLX'] Gene_or_gene_productt&interceding-token ngrams: not in cellstde2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='PLX'] controller:Gene_or_gene_productt*interceding-token ngrams: wild-type BRAF .tRe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='erk1'] controlledt|e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='plx7904'] controller:Gene_or_gene_productt)interceding-token ngrams: expressing botht&e1: args2Role-mention-ngram: ( IR-A ort)interceding-token ngrams: hemireceptors ,t#interceding-token ngrams: with hight+e1: args2Role-mention-ngram: THEME isoformst#e1: args2Role-mention-ngram: IR-B )tae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='isoform'] >nn [lemma='insulin'] themetdobj [lemma='igf-i'] Gene_or_gene_productt"interceding-token ngrams: IGF-II (t,interceding-token ngrams: , IR hemireceptorst$e2: args2Role-mention-ngram: THEME )t$e1: ents2Label-mention-ngram: ( IR-At$interceding-token ngrams: ( IGF-IR )tVe1: trigger-arg-path: binds:Binding >dobj [lemma='insulin'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: isoforms ( IR-At%interceding-token ngrams: IGF-IR , IRt$interceding-token ngrams: and IGF-IRt%e1: ents2Label-mention-ngram: IR-A ortge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='insulin'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: IR-A ort-interceding-token ngrams: formation of hybridt>e2: trigger-arg-path: bind:Binding >dobj [lemma='igf-i'] themet)interceding-token ngrams: high affinity ,t_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='igf-i'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: which bind GENE_OR_GENE_PRODUCTt!e1: args2Role-mention-ngram: IR-At"interceding-token ngrams: left ) .tae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='insulin'] Gene_or_gene_productt)e2: args2Role-mention-ngram: , which bindt&e2: args2Role-mention-ngram: THEME ) ,t/e2: trigger-arg-path: bind:Binding nsubj [lemma='isoform'] >nn [lemma='insulin'] themet#interceding-token ngrams: hybrid IRtIe2: trigger-arg-path: bind dobj [lemma='insulin'] Gene_or_gene_productt$interceding-token ngrams: affinity ,t6e2: trigger-arg-path: bind >dobj [lemma='igf-i'] themet'interceding-token ngrams: IR and IGF-IRt$interceding-token ngrams: and IGF-IIt&e1: args2Role-mention-ngram: or IR-B )t*e1: ents2Label-mention-ngram: IR-A or IR-Bt;e1: trigger-arg-path: Binding >dobj [lemma='insulin'] themetHe1: trigger-arg-path: binds >dobj [lemma='insulin'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >dobj [lemma='insulin'] themet-e1: args2Role-mention-ngram: THEME isoforms (t9e2: trigger-arg-path: Binding >dobj [lemma='igf-i'] themetEe2: trigger-arg-path: bind >dobj [lemma='igf-i'] Gene_or_gene_productt interceding-token ngrams: IGF-IRtve1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='isoform'] >nn [lemma='insulin'] theme:Gene_or_gene_productt$interceding-token ngrams: receptor (tWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='igf-i'] Gene_or_gene_productt interceding-token ngrams: IGF-IIt'e1: args2Role-mention-ngram: isoforms (t7e2: ents2Label-mention-ngram: bind GENE_OR_GENE_PRODUCTt'interceding-token ngrams: ) binds IGF-It4e2: trigger-arg-path: bind nsubj [lemma='isoform'] >nn [lemma='insulin'] Gene_or_gene_producttinterceding-token ngrams: , IRt#interceding-token ngrams: IGF-IRs (t'e1: ents2Label-mention-ngram: or IR-B )t(e1: ents2Label-mention-ngram: isoforms (tpe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='isoform'] >nn [lemma='insulin'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='insulin'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='igf-i'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: or IR-Btge1: trigger-arg-path: Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] theme:Gene_or_gene_producttae1: trigger-arg-path: Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] Gene_or_gene_productt$e1: args2Role-mention-ngram: or IR-BtNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='isoform'] >nn [lemma='insulin'] themet>e2: trigger-arg-path: bind:Binding dobj [lemma='insulin'] theme:Gene_or_gene_productt*interceding-token ngrams: affinity , whiletCe2: trigger-arg-path: bind dobj [lemma='igf-i'] themet'e2: args2Role-mention-ngram: which bindt'e2: trigger-arg-path: bind dobj [lemma='insulin'] theme:Gene_or_gene_productt3interceding-token ngrams: with IGF-IR hemireceptorst(interceding-token ngrams: IGF-IR ) bindst)e1: args2Role-mention-ngram: IR-B ) bindstPe1: trigger-arg-path: Binding >dobj [lemma='insulin'] theme:Gene_or_gene_producttinterceding-token ngrams: leftt*interceding-token ngrams: IGF-I and IGF-IIt#interceding-token ngrams: of hybridtDe2: trigger-arg-path: bind:Binding dobj [lemma='igf-i'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: which bindt*interceding-token ngrams: IGF-I receptor (t9e1: trigger-arg-path: binds >dobj [lemma='insulin'] themetNe2: trigger-arg-path: Binding >dobj [lemma='igf-i'] theme:Gene_or_gene_producttge1: trigger-arg-path: binds:Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] Gene_or_gene_productt interceding-token ngrams: ( lefttxe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] Gene_or_gene_producttFe2: trigger-arg-path: Binding dobj [lemma='igf-i'] themet*interceding-token ngrams: to the formationt/interceding-token ngrams: cells expressing botht"interceding-token ngrams: ( left )t"interceding-token ngrams: IGF-IR )t%interceding-token ngrams: while IGF-ItUe2: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='igf-i'] Gene_or_gene_productt"interceding-token ngrams: IGF-IR ,t-interceding-token ngrams: heterodimerize withtSe2: trigger-arg-path: bind:Binding >dobj [lemma='igf-i'] theme:Gene_or_gene_producttinterceding-token ngrams: IRt"interceding-token ngrams: In cellst$e1: ents2Label-mention-ngram: IR-B )t!interceding-token ngrams: ) bindst~e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] theme:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='insulin'] Gene_or_gene_productt(interceding-token ngrams: IR and IGF-IRst.interceding-token ngrams: IGF-IR hemireceptorst.interceding-token ngrams: while IGF-I receptort'interceding-token ngrams: hybrid IR andt(interceding-token ngrams: IGF-I receptort%interceding-token ngrams: with IGF-IRt&interceding-token ngrams: and IGF-IR ,t:interceding-token ngrams: hemireceptors may heterodimerizet%interceding-token ngrams: and IGF-IRst;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT isoformst(interceding-token ngrams: heterodimerizet4interceding-token ngrams: heterodimerize with IGF-IRt.interceding-token ngrams: IR hemireceptors mayt,interceding-token ngrams: expressing both IRtKe2: trigger-arg-path: bind:Binding dobj [lemma='insulin'] themetee1: trigger-arg-path: binds >nsubj [lemma='isoform'] >nn [lemma='insulin'] theme:Gene_or_gene_productt'interceding-token ngrams: hemireceptorst7e2: trigger-arg-path: Binding dobj [lemma='igf-i'] theme:Gene_or_gene_producttXe1: trigger-arg-path: binds:Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] themet"interceding-token ngrams: ( IGF-IRtinterceding-tokens-full-span: with high affinity , while IGF-I receptor ( IGF-IR ) binds IGF-I and IGF-II ( left ) . In cells expressing both IR and IGF-IR , IR hemireceptors may heterodimerize with IGF-IR hemireceptors , leading to the formation of hybrid IR and IGF-IRs (t+interceding-token ngrams: receptor ( IGF-IRt'interceding-token ngrams: , while IGF-It*interceding-token ngrams: cells expressingtinterceding-token ngrams: IGF-It*interceding-token ngrams: IR hemireceptorst-CSSPATH: ROOT  ++ ROOT >xcomp >prep_to >rcmodt%interceding-token ngrams: both IR andtRe1: trigger-arg-path: Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] themet'interceding-token ngrams: and IGF-IRs (t!e1: args2Role-mention-ngram: IR-BtLe2: trigger-arg-path: Binding dobj [lemma='insulin'] themet:e1: ents2Label-mention-ngram: ) binds GENE_OR_GENE_PRODUCTt0interceding-token ngrams: IGF-IR hemireceptors ,t!interceding-token ngrams: both IRt-interceding-token ngrams: In cells expressingtme1: trigger-arg-path: binds:Binding >nsubj [lemma='isoform'] >nn [lemma='insulin'] theme:Gene_or_gene_producttYe2: trigger-arg-path: interact:Positive_regulation >nsubj controller:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by [lemma='phosphorylate'] PhosphorylationtLe2: trigger-arg-path: interact:Positive_regulation >prepc_by Phosphorylationt/interceding-token ngrams: proliferation throught]e2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by [lemma='phosphorylate'] controlledtPe2: trigger-arg-path: interact >prepc_by [lemma='phosphorylate'] Phosphorylationt*e2: args2Role-mention-ngram: by CONTROLLEDt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can alsotpe2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj [lemma='GSK-3'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and TSC2tCinterceding-token ngrams: negatively-regulate proliferation throughtVe2: trigger-arg-path: Positive_regulation >prepc_by [lemma='phosphorylate'] controlledtWe2: trigger-arg-path: interact:Positive_regulation >prepc_by controlled:Phosphorylationt^e2: trigger-arg-path: interact:Positive_regulation >nsubj [lemma='GSK-3'] Gene_or_gene_producttTe2: trigger-arg-path: interact:Positive_regulation >nsubj [lemma='GSK-3'] controllert?interceding-token ngrams: can negatively-regulate proliferationtYe2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by controlledtUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3'] controllertNe2: trigger-arg-path: Positive_regulation >prepc_by controlled:Phosphorylationt3interceding-token ngrams: through mTORC1 inhibitiont`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: TSC2 by phosphorylatingtDe2: trigger-arg-path: interact:Positive_regulation >nsubj controllertge2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by PhosphorylationtEe2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by controlledtNe2: trigger-arg-path: interact:Positive_regulation >nsubj Gene_or_gene_productt[e2: trigger-arg-path: Positive_regulation >prepc_by [lemma='phosphorylate'] PhosphorylationtEe2: trigger-arg-path: interact >nsubj controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: TSC1tfe2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj [lemma='GSK-3'] controllert?e2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by [lemma='phosphorylate'] controlled:PhosphorylationtCe2: trigger-arg-path: interact >prepc_by controlled:Phosphorylationt@e2: trigger-arg-path: interact >nsubj [lemma='GSK-3'] controllertUe2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by controlled:Phosphorylationt'interceding-token ngrams: and GSK-3betatfe2: trigger-arg-path: Positive_regulation >prepc_by [lemma='phosphorylate'] controlled:Phosphorylationt0e2: trigger-arg-path: interact >nsubj controllert2interceding-token ngrams: and GSK-3beta activationt(interceding-token ngrams: through mTORC1t+interceding-token ngrams: mTORC1 inhibitiont*e2: args2Role-mention-ngram: with TSC1 andtie2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by controlled:Phosphorylationt6interceding-token ngrams: proliferation through mTORC1t1interceding-token ngrams: can negatively-regulatetqe2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >prepc_by [lemma='phosphorylate'] controlledt{e2: trigger-arg-path: lemmatizedTrigger=interact:Positive_regulation >nsubj [lemma='GSK-3'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by [lemma='phosphorylate'] Phosphorylationt)e2: ents2Label-mention-ngram: and TSC2 byt.interceding-token ngrams: GSK-3beta activationt0e2: args2Role-mention-ngram: CONTROLLER can alsot2interceding-token ngrams: inhibition and GSK-3betat(interceding-token ngrams: inhibition andt>e2: trigger-arg-path: Positive_regulation >prepc_by controlledtKe2: trigger-arg-path: interact >prepc_by [lemma='phosphorylate'] controlledtCe2: trigger-arg-path: Positive_regulation >prepc_by Phosphorylationt-interceding-token ngrams: negatively-regulatet;interceding-token ngrams: negatively-regulate proliferationt%e2: args2Role-mention-ngram: TSC1 andt_e2: trigger-arg-path: interact:Positive_regulation >prepc_by [lemma='phosphorylate'] controlledt/e2: args2Role-mention-ngram: TSC2 by CONTROLLEDtoe2: trigger-arg-path: interact:Positive_regulation >prepc_by [lemma='phosphorylate'] controlled:Phosphorylationtde2: trigger-arg-path: interact:Positive_regulation >prepc_by [lemma='phosphorylate'] Phosphorylationtie2: trigger-arg-path: interact:Positive_regulation >nsubj [lemma='GSK-3'] controller:Gene_or_gene_productt0interceding-token ngrams: GSK-3beta activation .txinterceding-tokens-full-span: can negatively-regulate proliferation through mTORC1 inhibition and GSK-3beta activation .t+e2: ents2Label-mention-ngram: with TSC1 andtJe2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by Phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=interact >prepc_by [lemma='phosphorylate'] controlled:Phosphorylationt*e2: args2Role-mention-ngram: TSC1 and TSC2tGe2: trigger-arg-path: interact:Positive_regulation >prepc_by controlledt%e2: ents2Label-mention-ngram: TSC2 byt&e2: ents2Label-mention-ngram: TSC1 andtUe2: trigger-arg-path: interact >nsubj [lemma='GSK-3'] controller:Gene_or_gene_productt#interceding-token ngrams: GSK-3betat(e2: args2Role-mention-ngram: and TSC2 byt&e2: args2Role-mention-ngram: with TSC1t!e2: args2Role-mention-ngram: TSC1t'e2: ents2Label-mention-ngram: with TSC1t0e2: ents2Label-mention-ngram: interact with TSC1t%e2: args2Role-mention-ngram: and TSC2t+e2: ents2Label-mention-ngram: TSC1 and TSC2t8e2: trigger-arg-path: interact >prepc_by Phosphorylationt/e2: args2Role-mention-ngram: interact with TSC1t3e2: trigger-arg-path: interact >prepc_by controlledtRe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='GSK-3'] controllert/interceding-token ngrams: mTORC1 inhibition andt[e2: trigger-arg-path: interact >prepc_by [lemma='phosphorylate'] controlled:Phosphorylationt$e2: args2Role-mention-ngram: TSC2 bytxe1: trigger-arg-path: binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] themetinterceding-token ngrams: p85t?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='protein'] >amod [lemma='irs-4'] Gene_or_gene_productte1: trigger-arg-path: binding prep_to [lemma='protein'] >amod [lemma='irs-4'] Gene_or_gene_producttpe1: trigger-arg-path: Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] themet?e1: trigger-arg-path: binding prep_to [lemma='protein'] >amod [lemma='irs-4'] theme:Gene_or_gene_productt/interceding-token ngrams: regulatory subunit oft&interceding-token ngrams: with the p85t$interceding-token ngrams: or insulintZe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >amod Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs6'] Gene_or_gene_productt5interceding-token ngrams: other downstream signallingtHe1: trigger-arg-path: binding prep_to >amod Gene_or_gene_productt*interceding-token ngrams: PI3K in responsetpe1: trigger-arg-path: binding prep_to [lemma='protein'] >amod [lemma='irs-4'] themet*interceding-token ngrams: IGF-I , allowingtPe1: trigger-arg-path: binding:Binding prep_to >amod Gene_or_gene_productt$interceding-token ngrams: to IGF-I ,t0interceding-token ngrams: p85 regulatory subunittde2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs6'] Gene_or_gene_productt:e2: trigger-arg-path: Binding >nsubj [lemma='socs6'] themet#interceding-token ngrams: weakly totPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pim3'] themet/interceding-token ngrams: insulin stimulation ,tVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs6'] themet5interceding-token ngrams: thus preventing recruitmentt.interceding-token ngrams: indirectly associatet"interceding-token ngrams: to IRS-2tPe2: trigger-arg-path: interact >nsubj [lemma='socs6'] theme:Gene_or_gene_productt interceding-token ngrams: weaklytNe1: trigger-arg-path: Binding prep_to >amod theme:Gene_or_gene_producttMe2: trigger-arg-path: interact >prep_with [lemma='pim3'] Gene_or_gene_productt$interceding-token ngrams: of PI3K int\e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs6'] Gene_or_gene_productt%interceding-token ngrams: to IGF-I ortIe2: trigger-arg-path: Binding >nsubj [lemma='socs6'] Gene_or_gene_productt#interceding-token ngrams: associatetme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pim3'] theme:Gene_or_gene_productt.interceding-token ngrams: recruitment of othertJe2: trigger-arg-path: interact >nsubj [lemma='socs6'] Gene_or_gene_productt-interceding-token ngrams: of other downstreamtAe1: trigger-arg-path: binding:Binding prep_to >amod themetCe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs6'] themet1interceding-token ngrams: to indirectly associatet"interceding-token ngrams: and moret(interceding-token ngrams: or insulin andt+interceding-token ngrams: response to IGF-It=e2: trigger-arg-path: Binding >prep_with [lemma='pim3'] themetQe1: trigger-arg-path: binding >prep_of [lemma='socs6'] theme:Gene_or_gene_productt$interceding-token ngrams: subunit oftUe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs6'] themet%interceding-token ngrams: more weaklyt,interceding-token ngrams: associate with thet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] themet0interceding-token ngrams: preventing recruitmenttVe1: trigger-arg-path: binding:Binding prep_to >amod theme:Gene_or_gene_productt,interceding-token ngrams: stimulation , thustge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pim3'] Gene_or_gene_productt(interceding-token ngrams: allowing it tothe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >amod theme:Gene_or_gene_productt%interceding-token ngrams: allowing ittprep_of [lemma='socs6'] themetXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pim3'] themet,interceding-token ngrams: the p85 regulatoryt)interceding-token ngrams: weakly to IRS-2t3interceding-token ngrams: indirectly associate witht*interceding-token ngrams: IGF-I or insulint?e1: trigger-arg-path: binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] Gene_or_gene_producttRe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs6'] Gene_or_gene_productt"interceding-token ngrams: IGF-I ort(interceding-token ngrams: associate witht0interceding-token ngrams: its phosphorylation int`e1: trigger-arg-path: lemmatizedTrigger=binding prep_to >amod theme:Gene_or_gene_productt/interceding-token ngrams: signalling proteins .t-interceding-token ngrams: its phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] Gene_or_gene_producttHe1: trigger-arg-path: Binding prep_to >amod Gene_or_gene_productt%interceding-token ngrams: insulin andtKe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >amod themet*interceding-token ngrams: it to indirectlyt.e2: args2Role-mention-ngram: may also interacttee1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs6'] Gene_or_gene_productt[e2: trigger-arg-path: interact:Binding >prep_with [lemma='pim3'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs6'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >amod Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] theme:Gene_or_gene_producttXe2: trigger-arg-path: interact:Binding >nsubj [lemma='socs6'] theme:Gene_or_gene_producttSe1: trigger-arg-path: binding:Binding >prep_of [lemma='socs6'] Gene_or_gene_productt"interceding-token ngrams: to IGF-ItQe1: trigger-arg-path: Binding >prep_of [lemma='socs6'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interact >prep_with [lemma='pim3'] theme:Gene_or_gene_productt%interceding-token ngrams: to IRS-2 intKinterceding-tokens-full-span: following its phosphorylation in response to IGF-I or insulin and more weakly to IRS-2 in response to IGF-I , allowing it to indirectly associate with the p85 regulatory subunit of PI3K in response to IGF-I or insulin stimulation , thus preventing recruitment of other downstream signalling proteins .t*interceding-token ngrams: insulin and moretYe1: trigger-arg-path: binding:Binding >prep_of [lemma='socs6'] theme:Gene_or_gene_productt7interceding-token ngrams: following its phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='protein'] >amod [lemma='irs-4'] themet+interceding-token ngrams: , thus preventingtDe1: trigger-arg-path: binding:Binding >prep_of [lemma='socs6'] themetNe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs6'] themetKe1: trigger-arg-path: Binding >prep_of [lemma='socs6'] Gene_or_gene_productt;e2: trigger-arg-path: interact >nsubj [lemma='socs6'] themet-interceding-token ngrams: insulin stimulationtee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pim3'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding prep_to >amod themetinterceding-token ngrams: IRS-2t_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pim3'] Gene_or_gene_productt!interceding-token ngrams: the p85t+interceding-token ngrams: IRS-2 in responsetKe1: trigger-arg-path: binding >prep_of [lemma='socs6'] Gene_or_gene_producttFe2: trigger-arg-path: interact:Binding >prep_with [lemma='pim3'] themet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='protein'] >amod [lemma='irs-4'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: may also interactt!interceding-token ngrams: IGF-I ,t3interceding-token ngrams: preventing recruitment oftprep_of [lemma='socs6'] themet?e1: trigger-arg-path: binding:Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] theme:Gene_or_gene_productt$interceding-token ngrams: preventingtMe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='socs6'] themet(interceding-token ngrams: more weakly tot9e1: trigger-arg-path: binding prep_to >amod themet'interceding-token ngrams: , allowing itt"interceding-token ngrams: IRS-2 int(interceding-token ngrams: p85 regulatoryt,interceding-token ngrams: phosphorylation int5interceding-token ngrams: phosphorylation in responset)interceding-token ngrams: thus preventingtCSSPATH: ROOT >agent ++ ROOT t(interceding-token ngrams: recruitment oftRe2: trigger-arg-path: Binding >prep_with [lemma='pim3'] theme:Gene_or_gene_productt8interceding-token ngrams: downstream signalling proteinst'interceding-token ngrams: following itst#interceding-token ngrams: followingt$interceding-token ngrams: , allowingtje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='socs6'] theme:Gene_or_gene_productt0interceding-token ngrams: or insulin stimulationtNe1: trigger-arg-path: binding prep_to >amod theme:Gene_or_gene_productt$interceding-token ngrams: proteins .tLe2: trigger-arg-path: Binding >prep_with [lemma='pim3'] Gene_or_gene_productt'interceding-token ngrams: to indirectlytUe2: trigger-arg-path: interact:Binding >prep_with [lemma='pim3'] Gene_or_gene_productt)interceding-token ngrams: subunit of PI3Kt)interceding-token ngrams: and more weaklytke1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs6'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs6'] theme:Gene_or_gene_productt/interceding-token ngrams: downstream signallingtSe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >amod themetOe2: trigger-arg-path: Binding >nsubj [lemma='socs6'] theme:Gene_or_gene_productt>e2: trigger-arg-path: interact >prep_with [lemma='pim3'] themete1: trigger-arg-path: Binding prep_to [lemma='protein'] >amod [lemma='irs-4'] Gene_or_gene_productt-interceding-token ngrams: signalling proteinst*interceding-token ngrams: other downstreamt,interceding-token ngrams: regulatory subunitt!interceding-token ngrams: PI3K int!interceding-token ngrams: of PI3Kt!interceding-token ngrams: ( eIF4GtQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eif4e'] themetinterceding-token ngrams: 4GtWe1: trigger-arg-path: interacts:Binding >prep_with [lemma='eif4e'] Gene_or_gene_productt/interceding-token ngrams: binding of eukaryotict#interceding-token ngrams: of the 4Ft!e1: ents2Label-mention-ngram: capt.interceding-token ngrams: the 4F translationalt%e1: ents2Label-mention-ngram: the captfe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eif4e'] theme:Gene_or_gene_productt)interceding-token ngrams: for the bindingt$interceding-token ngrams: ) to eIF4Etinterceding-token ngrams: eIF4Et#interceding-token ngrams: competingt.interceding-token ngrams: initiation complex (t,e1: args2Role-mention-ngram: binding proteint*interceding-token ngrams: by competing fortBe1: ents2Label-mention-ngram: binding protein GENE_OR_GENE_PRODUCTt\e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='mtorc1'] controllert$interceding-token ngrams: eIF4G ) tot!interceding-token ngrams: eIF4F )t'interceding-token ngrams: translationaltqe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='mtorc1'] controller:Gene_or_gene_productt$interceding-token ngrams: to eIF4E .tHe1: trigger-arg-path: interacts:Binding >prep_with [lemma='eif4e'] themet&interceding-token ngrams: prevents thet;e1: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] themetinterceding-token ngrams: 4G (t%interceding-token ngrams: factor 4G (t%interceding-token ngrams: the bindingtJe2: trigger-arg-path: phosphorylation >prep_by [lemma='mtorc1'] controllert interceding-token ngrams: the 4Ft&interceding-token ngrams: by competingtUe1: trigger-arg-path: interacts >prep_with [lemma='eif4e'] theme:Gene_or_gene_productt_e2: trigger-arg-path: phosphorylation >prep_by [lemma='mtorc1'] controller:Gene_or_gene_producttTe2: trigger-arg-path: phosphorylation >prep_by [lemma='mtorc1'] Gene_or_gene_productt'interceding-token ngrams: competing fortMe1: trigger-arg-path: Binding >prep_with [lemma='eif4e'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt2interceding-token ngrams: of eukaryotic initiationtse2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] controller:Gene_or_gene_producttRe1: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt*interceding-token ngrams: 4F translationalt0e1: ents2Label-mention-ngram: interacts with thetLe1: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] Gene_or_gene_productt e1: args2Role-mention-ngram: capt/e1: args2Role-mention-ngram: interacts with thet#interceding-token ngrams: factor 4Gt0interceding-token ngrams: prevents the formationt:e1: ents2Label-mention-ngram: protein GENE_OR_GENE_PRODUCTtOe1: trigger-arg-path: interacts >prep_with [lemma='eif4e'] Gene_or_gene_productt]e1: trigger-arg-path: interacts:Binding >prep_with [lemma='eif4e'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt!interceding-token ngrams: ( eIF4Ft]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] Gene_or_gene_productt"interceding-token ngrams: preventstinterceding-token ngrams: 4Ft'interceding-token ngrams: of eukaryotictZe1: trigger-arg-path: interacts:Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt2interceding-token ngrams: translational initiationt/interceding-token ngrams: eukaryotic initiationt#interceding-token ngrams: eIF4F ) ;t.interceding-token ngrams: initiation factor 4Gt1e1: ents2Label-mention-ngram: cap binding proteintYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eif4e'] themet,e1: args2Role-mention-ngram: the cap bindingt$interceding-token ngrams: eukaryotictpe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] controllertXe2: trigger-arg-path: Positive_regulation >prep_by [lemma='mtorc1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: with the captinterceding-token ngrams: eIF4Gt)e1: ents2Label-mention-ngram: cap bindingtke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] controllertee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] Gene_or_gene_productt#interceding-token ngrams: ( eIF4G )tce2: trigger-arg-path: Positive_regulation >prep_by [lemma='mtorc1'] controller:Gene_or_gene_productt(interceding-token ngrams: ; by competingtNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] themet$interceding-token ngrams: initiationtne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eif4e'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >prep_by [lemma='mtorc1'] controllert>e1: trigger-arg-path: Binding >prep_with [lemma='eif4e'] themet&interceding-token ngrams: and preventstinterceding-token ngrams: ; byt,interceding-token ngrams: initiation complext6interceding-token ngrams: eukaryotic initiation factortfe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='mtorc1'] Gene_or_gene_producttEe1: trigger-arg-path: interacts:Binding >nsubj [lemma='4e-bp1'] themet-e1: ents2Label-mention-ngram: binding proteint$interceding-token ngrams: 4G ( eIF4Gt*e1: args2Role-mention-ngram: protein THEMEtTe1: trigger-arg-path: interacts:Binding >nsubj [lemma='4e-bp1'] Gene_or_gene_productt:interceding-token ngrams: translational initiation complextinterceding-token ngrams: eIF4Ft#interceding-token ngrams: ( eIF4F )t+interceding-token ngrams: initiation factort2e1: args2Role-mention-ngram: binding protein THEMEt"interceding-token ngrams: to eIF4Ethe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] Gene_or_gene_productt(e1: args2Role-mention-ngram: cap bindingt0e1: args2Role-mention-ngram: cap binding proteint?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] controller:Gene_or_gene_productt*interceding-token ngrams: formation of thet!interceding-token ngrams: eIF4G )t(interceding-token ngrams: the binding oft$e1: args2Role-mention-ngram: the capt5interceding-token ngrams: 4F translational initiationt+interceding-token ngrams: competing for thet!interceding-token ngrams: eIF4E .tVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] themetSe1: trigger-arg-path: Binding >prep_with [lemma='eif4e'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: with the capt@e1: trigger-arg-path: interacts >prep_with [lemma='eif4e'] themethe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='eif4e'] Gene_or_gene_productt interceding-token ngrams: ) ; bytinterceding-token ngrams: ) ;t=e1: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] themet)interceding-token ngrams: complex ( eIF4Ft*interceding-token ngrams: and prevents thetze2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='mtorc1'] Gene_or_gene_productt?interceding-tokens-full-span: and prevents the formation of the 4F translational initiation complex ( eIF4F ) ; by competing for the binding of eukaryotic initiation factor 4G ( eIF4G ) to eIF4E .t`e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='eif4e'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: the cap bindingtJe1: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] Gene_or_gene_productt?interceding-tokens-full-span: and ERK1 , enhances their interaction and recruits these complexes to late endosomes . MP and 1 complex is anchored to the endosomal membrane by means oft4interceding-token ngrams: enhances their interactiont(interceding-token ngrams: enhances theirt*interceding-token ngrams: , enhances theirt/interceding-token ngrams: their interaction andt+interceding-token ngrams: their interactiont(CSSPATH: ROOT  ++ ROOT >prep_by_means_oft2interceding-token ngrams: interaction and recruitst_e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj [lemma='protein'] >nn [lemma='rb'] themet#e2: args2Role-mention-ngram: , thattde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='rb'] themetSe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='family'] theme:FamilytSe2: trigger-arg-path: mediates:Positive_regulation nsubj [lemma='protein'] >nn [lemma='rb'] themet@e1: trigger-arg-path: bind >nsubj >nn theme:Gene_or_gene_productt(interceding-token ngrams: a complex withthe2: trigger-arg-path: mediates:Positive_regulation nsubj [lemma='protein'] >nn [lemma='rb'] Gene_or_gene_productt1interceding-token ngrams: phosphorylation by Cdk4t(interceding-token ngrams: cyclin E formst*interceding-token ngrams: gene , includingt,interceding-token ngrams: are inactivated byt*interceding-token ngrams: transcription oftAe1: trigger-arg-path: bind >prep_to [lemma='family'] theme:FamilytUe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation e1: trigger-arg-path: Binding >prep_to [lemma='family'] FamilytZe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='protein'] >nn [lemma='rb'] Gene_or_gene_productt-interceding-token ngrams: including cyclin E.tTe2: trigger-arg-path: mediates prep_to [lemma='family'] themet.interceding-token ngrams: transcription of E2Ft[e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='family'] theme:Familyt'interceding-token ngrams: and 6-cyclinDt,interceding-token ngrams: E2F dependent genet(interceding-token ngrams: dependent genetje2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation prep_to [lemma='family'] Familyt?e2: trigger-arg-path: mediates prep_to [lemma='family'] themet$interceding-token ngrams: function .tDe1: trigger-arg-path: Binding >prep_to [lemma='family'] theme:Familyt%interceding-token ngrams: by Cdk4 andt%interceding-token ngrams: complexes ,t:e1: trigger-arg-path: bind >nsubj >nn Gene_or_gene_producttDe2: trigger-arg-path: mediates:Positive_regulation nsubj [lemma='protein'] >nn [lemma='rb'] theme:Gene_or_gene_productt.interceding-token ngrams: Upregulated cyclin EtLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='family'] themet&interceding-token ngrams: complex witht(interceding-token ngrams: their functiont"interceding-token ngrams: . Duringt"interceding-token ngrams: Cdk4 andt/interceding-token ngrams: 6-cyclinD complexes ,tTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='family'] themet)interceding-token ngrams: forms a complext%interceding-token ngrams: Upregulatedt)interceding-token ngrams: Rb proteins aret*interceding-token ngrams: of E2F dependentt*interceding-token ngrams: inactivate theirt"interceding-token ngrams: , the RbtHe1: trigger-arg-path: bind:Binding >nsubj >nn theme:Gene_or_gene_productt/interceding-token ngrams: by phosphorylation bytRe1: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='rb'] themet_e1: trigger-arg-path: bind >nsubj [lemma='protein'] >nn [lemma='rb'] theme:Gene_or_gene_productt,interceding-token ngrams: phosphorylation byt1interceding-token ngrams: proteins and inactivatetge1: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] >nn [lemma='rb'] theme:Gene_or_gene_producttinterceding-token ngrams: G1 ,t#interceding-tokens-full-span: of proteins and inactivate their function . During G1 , the Rb proteins are inactivated by phosphorylation by Cdk4 and 6-cyclinD complexes , thereby allowing the transcription of E2F dependent gene , including cyclin E. Upregulated cyclin E forms a complex witht4interceding-token ngrams: allowing the transcriptiont)interceding-token ngrams: the Rb proteinst$e2: ents2Label-mention-ngram: , thatt(interceding-token ngrams: inactivated bytse1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='rb'] Gene_or_gene_productt*interceding-token ngrams: dependent gene ,tMe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='family'] Familyt#interceding-token ngrams: E forms atKe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='protein'] >nn [lemma='rb'] theme:Gene_or_gene_productt5e2: ents2Label-mention-ngram: hyperphosphorylation oft\e1: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='rb'] Gene_or_gene_producttIe1: trigger-arg-path: bind:Binding >prep_to [lemma='family'] theme:FamilytTe2: trigger-arg-path: Positive_regulation prep_to [lemma='family'] themet,interceding-token ngrams: , including cyclint/interceding-token ngrams: E. Upregulated cyclint)interceding-token ngrams: of proteins andt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='rb'] themet+e1: ents2Label-mention-ngram: proteins bindtUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='family'] Familyt%interceding-token ngrams: During G1 ,t,interceding-token ngrams: Upregulated cyclint%interceding-token ngrams: of proteinst!interceding-token ngrams: E formst#interceding-token ngrams: cyclin E.t*interceding-token ngrams: including cyclint:e2: trigger-arg-path: mediates prep_with >rcmodt3interceding-token ngrams: inactivate their functiont2e1: ents2Label-mention-ngram: SHARED proteins bindt.e2: args2Role-mention-ngram: that mediates thetYe2: trigger-arg-path: mediates:Positive_regulation nsubj >nn Gene_or_gene_productt+interceding-token ngrams: function . Duringtee2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='protein'] >nn [lemma='rb'] Gene_or_gene_productt.e2: args2Role-mention-ngram: CONTROLLER , thattinterceding-token ngrams: Et;e1: trigger-arg-path: bind >prep_to [lemma='family'] Familyt!interceding-token ngrams: by Cdk4tinterceding-token ngrams: Rbtqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='rb'] theme:Gene_or_gene_producttDe1: trigger-arg-path: activates >dobj [lemma='ra'] controlled:Familyt,e1: args2Role-mention-ngram: docking proteintQe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='ra'] controlledtUe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='ra'] controlled:Familyt)e1: args2Role-mention-ngram: factor SOS ,t'interceding-token ngrams: C-Raf and RaftHe1: trigger-arg-path: lemmatizedTrigger=activate >dobj controlled:Familyt!interceding-token ngrams: , K-Rast)e1: args2Role-mention-ngram: Grb2 and thet.e2: trigger-arg-path: Binding >iobj >nn Familyt#interceding-token ngrams: , B-Raf ,tinterceding-token ngrams: . Byt%interceding-token ngrams: , C-Raf andthe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj >nn controllertTe1: trigger-arg-path: lemmatizedTrigger=activate nsubj >nn controllertWe1: trigger-arg-path: activates:Positive_activation nsubj >nn controllert-e1: ents2Label-mention-ngram: and the guaninet'interceding-token ngrams: A-Raf , B-Raft?e1: trigger-arg-path: activates nsubj [lemma='receptor'] >nn [lemma='egfr'] controllert9e1: trigger-arg-path: activates >dobj [lemma='ra'] Familyt#interceding-token ngrams: , K-Ras ,tDe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj >nn themet#interceding-token ngrams: , N-Ras )tbe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='ra'] controlledt0e1: args2Role-mention-ngram: nucleotide exchanget-e1: args2Role-mention-ngram: CONTROLLER bindst3e1: args2Role-mention-ngram: the guanine nucleotidet+e2: trigger-arg-path: bound >iobj >nn themet3e1: ents2Label-mention-ngram: turn activates SHAREDt.e1: ents2Label-mention-ngram: activates SHAREDt e1: args2Role-mention-ngram: SOSt'interceding-token ngrams: by exchangingt"interceding-token ngrams: GTP . Bytinterceding-token ngrams: Raf (tQe2: trigger-arg-path: bound:Binding >iobj [lemma='launch'] >nn [lemma='ra'] themetEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj >nn Familyt4e1: ents2Label-mention-ngram: the guanine nucleotidet,interceding-token ngrams: exchanging GDP fortpe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj >nn controller:Complextiobj >nn themetinterceding-token ngrams: GTP .t#interceding-token ngrams: C-Raf andtinterceding-token ngrams: BytQe1: trigger-arg-path: lemmatizedTrigger=activate nsubj >nn Complext!interceding-token ngrams: for GTPt/e1: args2Role-mention-ngram: guanine nucleotidet$interceding-token ngrams: and Raf -1t!interceding-token ngrams: , C-Raft0e1: trigger-arg-path: activates >dobj controlledtae2: trigger-arg-path: lemmatizedTrigger=bind >iobj [lemma='launch'] >nn [lemma='ra'] theme:Familyt.e1: args2Role-mention-ngram: in turn activatestKe1: trigger-arg-path: activates nsubj >nn controller:ComplextTe1: trigger-arg-path: activates:Positive_activation nsubj >nn ComplextDe1: trigger-arg-path: activates:Positive_activation >dobj controlledt0interceding-token ngrams: binding and activatingt:e2: trigger-arg-path: bound:Binding >iobj >nn theme:FamilytQe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj Familyt#interceding-token ngrams: for GTP .t,e1: args2Role-mention-ngram: exchange factort1e1: args2Role-mention-ngram: activates CONTROLLEDt1e1: ents2Label-mention-ngram: the docking proteint'interceding-token ngrams: B-Raf , C-Raft,e1: ents2Label-mention-ngram: turn activatest!interceding-token ngrams: A-Raf ,t#interceding-token ngrams: ( H-Ras ,t,e1: trigger-arg-path: activates >dobj Familyt interceding-token ngrams: Raf -1tIe2: trigger-arg-path: bound >iobj [lemma='launch'] >nn [lemma='ra'] themet4e2: trigger-arg-path: bound:Binding >iobj >nn Familyt?e1: trigger-arg-path: Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] Complext=e1: trigger-arg-path: activates >dobj [lemma='ra'] controlledt*e1: ents2Label-mention-ngram: factor SOS ,tCe2: trigger-arg-path: lemmatizedTrigger=bind >iobj >nn theme:Familytdobj [lemma='ra'] Familyt6e1: args2Role-mention-ngram: turn activates CONTROLLEDt'e1: args2Role-mention-ngram: factor SOSt?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='receptor'] >nn [lemma='egfr'] controller:Complext?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='receptor'] >nn [lemma='egfr'] controllert3e2: trigger-arg-path: bound:Binding >iobj >nn themetce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj [lemma='launch'] >nn [lemma='ra'] Familyt0e1: args2Role-mention-ngram: the docking proteintAe1: trigger-arg-path: Positive_activation >dobj controlled:Familyt?e1: trigger-arg-path: activates:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controllert0e1: ents2Label-mention-ngram: guanine nucleotidet9e1: ents2Label-mention-ngram: guanine nucleotide exchanget(e1: ents2Label-mention-ngram: factor SOSt!interceding-token ngrams: ( H-Rastinterceding-token ngrams: N-RastCe1: trigger-arg-path: Positive_activation >dobj [lemma='ra'] FamilytMe1: trigger-arg-path: Positive_activation nsubj >nn controllertUe1: trigger-arg-path: Positive_activation nsubj >nn controller:Complext/e1: ents2Label-mention-ngram: binds the dockingt&interceding-token ngrams: . By bindingt\e1: trigger-arg-path: lemmatizedTrigger=activate nsubj >nn controller:Complext%interceding-token ngrams: GDP for GTPt$e1: args2Role-mention-ngram: guaninet)e1: ents2Label-mention-ngram: the guaninet,e2: trigger-arg-path: bound >iobj >nn Familytinterceding-token ngrams: K-Rast@e1: trigger-arg-path: activates nsubj >nn Complext=e1: trigger-arg-path: lemmatizedTrigger=activate >dobj Familyt_e1: trigger-arg-path: activates:Positive_activation nsubj >nn controller:Complext%e1: ents2Label-mention-ngram: guaninet@e1: trigger-arg-path: activates:Positive_activation >dobj FamilytNe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='ra'] controlledt1e1: ents2Label-mention-ngram: exchange factor SOSt*interceding-token ngrams: activating Raf (t2e2: trigger-arg-path: bound >iobj >nn theme:Familyt'interceding-token ngrams: H-Ras , K-Rastinterceding-token ngrams: B-Raft$interceding-token ngrams: By bindingt,e1: args2Role-mention-ngram: and the guaninetJe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='ra'] Familyt-e1: ents2Label-mention-ngram: exchange factort?e1: trigger-arg-path: Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controller:Complext-e1: ents2Label-mention-ngram: docking proteint-e1: args2Role-mention-ngram: protein Grb2 andtNe1: trigger-arg-path: Positive_activation >dobj [lemma='ra'] controlled:Familyt"e1: ents2Label-mention-ngram: Grb2tCe1: trigger-arg-path: activates nsubj >nn controllertXe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='ra'] controlled:Familyt%interceding-token ngrams: Raf ( A-RaftPe2: trigger-arg-path: bound >iobj [lemma='launch'] >nn [lemma='ra'] theme:Familyt interceding-token ngrams: -1 ) ,t%e1: ents2Label-mention-ngram: dockingt)e1: ents2Label-mention-ngram: SOS , whicht)e1: ents2Label-mention-ngram: the dockingt%e1: args2Role-mention-ngram: Grb2 andt$e1: args2Role-mention-ngram: dockingt?e1: trigger-arg-path: activates:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] Complext)interceding-token ngrams: ) by exchangingt8e1: args2Role-mention-ngram: guanine nucleotide exchanget7e1: trigger-arg-path: activates >dobj controlled:Familyt?e1: trigger-arg-path: activates:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controller:Complext/e1: ents2Label-mention-ngram: in turn activatestGe1: trigger-arg-path: Positive_activation >dobj [lemma='ra'] controlledt)e1: args2Role-mention-ngram: protein Grb2tKe1: trigger-arg-path: activates:Positive_activation >dobj controlled:Familyt7e1: args2Role-mention-ngram: nucleotide exchange factort?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controller:Complextbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj [lemma='launch'] >nn [lemma='ra'] themet!interceding-token ngrams: H-Ras ,t(interceding-token ngrams: By binding andt"interceding-token ngrams: Raf -1 )t(e1: args2Role-mention-ngram: the guaninet?e1: trigger-arg-path: activates nsubj [lemma='receptor'] >nn [lemma='egfr'] controller:Complext+e1: args2Role-mention-ngram: turn activatest$CSSPATH: ROOT >xcomp >rcmod ++ ROOT t$interceding-token ngrams: N-Ras ) bytinterceding-token ngrams: H-RastRe2: trigger-arg-path: Binding >iobj [lemma='launch'] >nn [lemma='ra'] theme:Familyt&e1: ents2Label-mention-ngram: Grb2 andt+interceding-token ngrams: by exchanging GDPtKe2: trigger-arg-path: Binding >iobj [lemma='launch'] >nn [lemma='ra'] themete1: trigger-arg-path: activates nsubj [lemma='receptor'] >nn [lemma='egfr'] Complextee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj >nn Complext(interceding-token ngrams: activating Raft-e2: trigger-arg-path: Binding >iobj >nn themet0e1: args2Role-mention-ngram: exchange factor SOStLe2: trigger-arg-path: Binding >iobj [lemma='launch'] >nn [lemma='ra'] Familyt!interceding-token ngrams: , N-RastMe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT GENE_OR_GENE_PRODUCT bindst2e1: ents2Label-mention-ngram: docking protein Grb2t!interceding-token ngrams: K-Ras ,t,interceding-token ngrams: and activating Raftie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj [lemma='launch'] >nn [lemma='ra'] theme:FamilytZe2: trigger-arg-path: lemmatizedTrigger=bind >iobj [lemma='launch'] >nn [lemma='ra'] themet(e1: ents2Label-mention-ngram: nucleotidet!e1: ents2Label-mention-ngram: SOSt1e1: ents2Label-mention-ngram: nucleotide exchangetGe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT GENE_OR_GENE_PRODUCTt$interceding-token ngrams: exchangingtie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='ra'] controlled:Familyt6e1: trigger-arg-path: Positive_activation >dobj Familyt?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='receptor'] >nn [lemma='egfr'] Complextinterceding-token ngrams: C-Raftinterceding-token ngrams: -1 )t8e1: ents2Label-mention-ngram: nucleotide exchange factortXe2: trigger-arg-path: bound:Binding >iobj [lemma='launch'] >nn [lemma='ra'] theme:Familyt[e2: trigger-arg-path: lemmatizedTrigger=bind >iobj [lemma='launch'] >nn [lemma='ra'] FamilytRe2: trigger-arg-path: bound:Binding >iobj [lemma='launch'] >nn [lemma='ra'] FamilytJe2: trigger-arg-path: bound >iobj [lemma='launch'] >nn [lemma='ra'] Familyt#interceding-token ngrams: ( A-Raf ,t?interceding-tokens-full-span: ( H-Ras , K-Ras , N-Ras ) by exchanging GDP for GTP . By binding and activating Raf ( A-Raf , B-Raf , C-Raf and Raf -1 ) ,tJe1: trigger-arg-path: Positive_activation nsubj >nn Complext=e2: trigger-arg-path: lemmatizedTrigger=bind >iobj >nn Familyt4e2: trigger-arg-path: Binding >iobj >nn theme:Familyt'interceding-token ngrams: K-Ras , N-Rastinterceding-token ngrams: -1t'e1: args2Role-mention-ngram: nucleotidet?e1: trigger-arg-path: Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controllert?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] Complext\e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlled:Familyt!interceding-token ngrams: ( A-Raft*e1: ents2Label-mention-ngram: protein Grb2t(e1: args2Role-mention-ngram: the dockingt!interceding-token ngrams: , B-Raft?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='receptor'] >nn [lemma='egfr'] controllert!interceding-token ngrams: B-Raf ,t(e1: args2Role-mention-ngram: SOS , whicht!interceding-token ngrams: GDP fort!e1: args2Role-mention-ngram: Grb2t#e1: ents2Label-mention-ngram: SOS ,t1e1: args2Role-mention-ngram: docking protein Grb2t!interceding-token ngrams: N-Ras )tKe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >iobj >nn theme:Familyt(interceding-token ngrams: exchanging GDPt"e1: args2Role-mention-ngram: SOS ,tMe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='ra'] Familyt1e1: args2Role-mention-ngram: CONTROLLER binds thet.e1: args2Role-mention-ngram: binds the dockingtUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] controllert8e1: args2Role-mention-ngram: IKKalpha complex CONTROLLEDt1e2: ents2Label-mention-ngram: SHARED and IKKalphatje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: IKKalpha complext~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] controllertUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] controllert~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: complex phosphorylatestIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] controllert1e1: args2Role-mention-ngram: and IKKalpha complextDe1: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] controllert;e2: ents2Label-mention-ngram: complex phosphorylates SHAREDt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] Gene_or_gene_productt-e2: args2Role-mention-ngram: IKKalpha complextSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_productt%e2: args2Role-mention-ngram: IKKalphatme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: and IKKalphatYe1: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] controller:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] controller:Gene_or_gene_producttXe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] controllertie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] controllert1e2: args2Role-mention-ngram: and IKKalpha complextXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] controllert;e1: ents2Label-mention-ngram: complex phosphorylates SHAREDt4e2: args2Role-mention-ngram: CONTROLLER and IKKalphat2e2: ents2Label-mention-ngram: and IKKalpha complextDe2: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] controllertIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] controllert/e1: args2Role-mention-ngram: complex CONTROLLEDt.e2: ents2Label-mention-ngram: SHARED at Ser536t&e2: ents2Label-mention-ngram: IKKalphatNe1: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: IKKalpha complextse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: complex phosphorylatest8e2: args2Role-mention-ngram: IKKalpha complex CONTROLLEDt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='nik'] Gene_or_gene_producttNe2: trigger-arg-path: phosphorylates >nsubj [lemma='nik'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: Ser536t=e1: ents2Label-mention-ngram: IKKalpha complex phosphorylatest=e2: ents2Label-mention-ngram: IKKalpha complex phosphorylatestbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_productt/e2: args2Role-mention-ngram: complex CONTROLLEDt)e2: args2Role-mention-ngram: and IKKalphatbe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: and IKKalpha complext-e1: args2Role-mention-ngram: IKKalpha complext4e1: args2Role-mention-ngram: CONTROLLER and IKKalphat1e1: ents2Label-mention-ngram: SHARED and IKKalphat.e1: ents2Label-mention-ngram: SHARED at Ser536t'e1: ents2Label-mention-ngram: at Ser536t^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='nik'] Gene_or_gene_producttme2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='nik'] controller:Gene_or_gene_productt+interceding-token ngrams: activates the JNKt)interceding-token ngrams: kinase linker (tinterceding-token ngrams: PIXt5interceding-token ngrams: guanine nucleotide-exchanget.interceding-token ngrams: in paxillin enhancest.interceding-token ngrams: Interacting exchanget?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlledtle2: trigger-arg-path: Binding prep_to [lemma='paxillin'] theme:Gene_or_gene_productt)interceding-token ngrams: activates Rac ,t"interceding-token ngrams: which int(interceding-token ngrams: turn activatest?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlled:Gene_or_gene_producttinterceding-token ngrams: S178t0e1: trigger-arg-path: promoting dobj [lemma='localization'] >nn [lemma='paxillin'] controlled:Gene_or_gene_producttTinterceding-tokens-full-span: localization to the cell membrane and the recruitment of paxillin kinase linker ( PKL ) and PAK Interacting exchange Factor ( PIX ) , a guanine nucleotide-exchange factor ( GEF ) that activates Rac , which in turn activates the JNK pathway . Interestingly , JNK phosphorylation of S178 in paxillin enhances thet'interceding-token ngrams: activates Ract&interceding-token ngrams: enhances thet:e2: trigger-arg-path: Binding >prep_of [lemma='fak'] themetinterceding-token ngrams: PKL )t-interceding-token ngrams: nucleotide-exchanget^e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation dobj >nn controlled:Gene_or_gene_producttRe1: trigger-arg-path: promoting:Positive_activation >dobj >nn Gene_or_gene_productt>e1: trigger-arg-path: promoting prep_to [lemma='paxillin'] Gene_or_gene_productt!interceding-token ngrams: PIX ) ,t+interceding-token ngrams: cell membrane andtinterceding-token ngrams: PIX )t~e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='paxillin'] theme:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation prep_to [lemma='paxillin'] themet interceding-token ngrams: Factort.e1: ents2Label-mention-ngram: SHARED promotingtTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='fak'] themet5e1: ents2Label-mention-ngram: SHARED promoting SHAREDtNe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn Gene_or_gene_productt!interceding-token ngrams: the JNKt"interceding-token ngrams: factor (t'interceding-token ngrams: which in turnt?e1: trigger-arg-path: promoting:Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlled:Gene_or_gene_productt#interceding-token ngrams: PKL ) andt!interceding-token ngrams: S178 inthe1: trigger-arg-path: Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlledtre1: trigger-arg-path: Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=promote conj_but >xcomp >prep_on >vmod ++ ROOT >dobjt%interceding-token ngrams: in paxillintinterceding-token ngrams: PKLtYe1: trigger-arg-path: promoting:Positive_activation prep_to [lemma='paxillin'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='fak'] theme:Gene_or_gene_producttle2: trigger-arg-path: binding prep_to [lemma='paxillin'] theme:Gene_or_gene_productt"interceding-token ngrams: linker (tYe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn controlled:Gene_or_gene_productthe1: trigger-arg-path: promoting >dobj [lemma='localization'] >nn [lemma='paxillin'] Gene_or_gene_productt&interceding-token ngrams: linker ( PKLt)interceding-token ngrams: the JNK pathwaytDe1: trigger-arg-path: Positive_activation dobj >nn controlledt]e1: trigger-arg-path: Positive_activation prep_of [lemma='fak'] theme:Gene_or_gene_productt"interceding-token ngrams: paxillint%interceding-token ngrams: Interactingt)interceding-token ngrams: PAK InteractingtLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='fak'] themetse1: trigger-arg-path: promoting >dobj [lemma='localization'] >nn [lemma='paxillin'] controlled:Gene_or_gene_productt(interceding-token ngrams: that activatestie1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation prep_to [lemma='paxillin'] Gene_or_gene_producttinterceding-token ngrams: ( PIXtDe1: trigger-arg-path: lemmatizedTrigger=promote >dobj >nn controlledt*interceding-token ngrams: ) that activatest!interceding-token ngrams: ( GEF )t!interceding-token ngrams: and PAKtIe2: trigger-arg-path: binding >prep_of [lemma='fak'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='fak'] Gene_or_gene_productt%interceding-token ngrams: Rac , whichtWe2: trigger-arg-path: binding prep_to [lemma='paxillin'] themet1interceding-token ngrams: recruitment of paxillint*interceding-token ngrams: S178 in paxillintle1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation prep_of [lemma='fak'] theme:Gene_or_gene_producttprep_of [lemma='fak'] themetae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='fak'] theme:Gene_or_gene_producttinterceding-token ngrams: ( PKLt&interceding-token ngrams: factor ( GEFtxe2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='paxillin'] Gene_or_gene_productt1interceding-token ngrams: phosphorylation of S178t4interceding-token ngrams: nucleotide-exchange factort%interceding-token ngrams: of paxillintDe1: trigger-arg-path: promoting:Positive_activation dobj [lemma='localization'] >nn [lemma='paxillin'] Gene_or_gene_productt)interceding-token ngrams: exchange FactortNe1: trigger-arg-path: lemmatizedTrigger=promote dobj >nn controlled:Gene_or_gene_productt>e1: trigger-arg-path: promoting >dobj >nn Gene_or_gene_productt&interceding-token ngrams: Factor ( PIXtre1: trigger-arg-path: promoting:Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlledt\e1: trigger-arg-path: promoting:Positive_activation dobj [lemma='localization'] >nn [lemma='paxillin'] Gene_or_gene_productt/interceding-token ngrams: , JNK phosphorylationtIe2: trigger-arg-path: Binding >prep_of [lemma='fak'] Gene_or_gene_productt}e1: trigger-arg-path: Positive_activation >dobj [lemma='localization'] >nn [lemma='paxillin'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='paxillin'] Gene_or_gene_productt7interceding-token ngrams: a guanine nucleotide-exchangetce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='fak'] Gene_or_gene_productt5interceding-token ngrams: Interacting exchange Factort!interceding-token ngrams: ( PIX )t$interceding-token ngrams: of S178 int*interceding-token ngrams: membrane and thet#interceding-token ngrams: ) and PAKt:e1: trigger-arg-path: promoting dobj [lemma='localization'] >nn [lemma='paxillin'] controlledt-interceding-token ngrams: Interestingly , JNKtne1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='localization'] >nn [lemma='paxillin'] controlledt-interceding-token ngrams: and the recruitmenttxe1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='localization'] >nn [lemma='paxillin'] Gene_or_gene_productt1e1: args2Role-mention-ngram: promoting CONTROLLEDt0interceding-token ngrams: JNK phosphorylation oftEe1: trigger-arg-path: promoting prep_to [lemma='paxillin'] themet-interceding-token ngrams: and PAK Interactingtinterceding-token ngrams: Rac ,t+interceding-token ngrams: exchange Factor (tbe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >nn Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=promote prep_to [lemma='paxillin'] theme:Gene_or_gene_producttinterceding-token ngrams: ) , at:e2: trigger-arg-path: binding >prep_of [lemma='fak'] themetHe1: trigger-arg-path: Positive_activation prep_of [lemma='fak'] Gene_or_gene_producttdobj >nn controlled:Gene_or_gene_productt1interceding-token ngrams: pathway . Interestinglyt$interceding-token ngrams: , which int_e2: trigger-arg-path: binding:Binding prep_to [lemma='paxillin'] themet4e1: trigger-arg-path: promoting >dobj >nn controlledtinterceding-token ngrams: ( GEFtinterceding-token ngrams: Ractie2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='paxillin'] themetTe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation prep_of [lemma='fak'] theme:Gene_or_gene_productt+interceding-token ngrams: in turn activatestinterceding-token ngrams: , JNKtRe1: trigger-arg-path: Positive_activation prep_to [lemma='paxillin'] Gene_or_gene_productt"interceding-token ngrams: Factor (tHe1: trigger-arg-path: promoting:Positive_activation >dobj >nn controlledtinterceding-token ngrams: GEF )tbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_producttXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] controllert~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_productt:e1: ents2Label-mention-ngram: also directly phosphorylatestme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] controller:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt5e2: args2Role-mention-ngram: CONTROLLER also directlyt2e2: ents2Label-mention-ngram: SHARED also directlyt:e2: ents2Label-mention-ngram: also directly phosphorylatestUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] controllertie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='erk'] controllert5e1: args2Role-mention-ngram: also directly CONTROLLEDtNe1: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] Gene_or_gene_producttDshortest-path: advmod [lemma='also']tDe1: trigger-arg-path: phosphorylates >nsubj [lemma='erk'] controllert2e1: ents2Label-mention-ngram: SHARED also directlyt5e1: args2Role-mention-ngram: CONTROLLER also directlyt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk'] Gene_or_gene_productt5e2: args2Role-mention-ngram: also directly CONTROLLEDt\e2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='myc'] Gene_or_gene_productt"interceding-token ngrams: prostatetbe2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlledt_e2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='myc'] Gene_or_gene_productt)interceding-token ngrams: EZH2 expressiont+interceding-token ngrams: its transcriptiont$interceding-token ngrams: , and EZH2t?e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] Gene_or_gene_productt'interceding-token ngrams: expression ist8e2: args2Role-mention-ngram: also upregulates CONTROLLEDtje2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='myc'] controller:Gene_or_gene_producttKe1: trigger-arg-path: binds >nsubj [lemma='myc'] theme:Gene_or_gene_producttle2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] Gene_or_gene_productt,interceding-token ngrams: EZH2 expression ist\e2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn controlled:Gene_or_gene_productt=e2: trigger-arg-path: upregulates >nsubj Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='ezh2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: upregulates:Positive_activation >dobj >nn controlled:Gene_or_gene_productt)interceding-token ngrams: prostate cancertoe2: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='ezh2'] controlled:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] themet,interceding-token ngrams: in prostate cancert_e1: trigger-arg-path: binds >prep_to [lemma='promoter'] >nn [lemma='ezh2'] Gene_or_gene_producttJe2: trigger-arg-path: upregulates:Positive_activation >dobj >nn controlledt0interceding-token ngrams: directly activates itstge1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] theme:Gene_or_gene_productt"interceding-token ngrams: with Myctpe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='ezh2'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='ezh2'] controlledtGe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn controlledtpe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='myc'] Gene_or_gene_producttHe2: trigger-arg-path: upregulates >nsubj controller:Gene_or_gene_productt5interceding-token ngrams: activates its transcriptiont"interceding-token ngrams: and EZH2tAe2: trigger-arg-path: upregulates >nsubj [lemma='myc'] controllertae1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] Gene_or_gene_productt+interceding-token ngrams: Myc expression intee2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn Gene_or_gene_productt5e2: ents2Label-mention-ngram: SHARED also upregulatestVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='myc'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt8e1: trigger-arg-path: Binding >nsubj [lemma='myc'] themet.e2: ents2Label-mention-ngram: also upregulatestne2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlledtbe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj Gene_or_gene_productt0e2: ents2Label-mention-ngram: upregulates SHAREDtTe2: trigger-arg-path: upregulates:Positive_activation >dobj >nn Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >nsubj [lemma='myc'] themet-interceding-token ngrams: and EZH2 expressiont?e2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlled:Gene_or_gene_productt\e2: trigger-arg-path: upregulates:Positive_activation >nsubj controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: upregulatest2interceding-token ngrams: expression is correlatedt0interceding-token ngrams: expression in prostatetPe1: trigger-arg-path: binds >prep_to [lemma='promoter'] >nn [lemma='ezh2'] themet'interceding-token ngrams: is correlatedt,interceding-token ngrams: directly activatest5e2: ents2Label-mention-ngram: also upregulates SHAREDt-e2: args2Role-mention-ngram: also upregulatestwe2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlled:Gene_or_gene_producttEe1: trigger-arg-path: binds >nsubj [lemma='myc'] Gene_or_gene_producttxe2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] Gene_or_gene_productte2: trigger: upregulatestNe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj Gene_or_gene_productt-interceding-token ngrams: its transcription ,tSe1: trigger-arg-path: binds:Binding >nsubj [lemma='myc'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='myc'] controllert8e2: args2Role-mention-ngram: CONTROLLER also upregulatestge2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='myc'] controller:Gene_or_gene_producttVe2: trigger-arg-path: upregulates >nsubj [lemma='myc'] controller:Gene_or_gene_productt?interceding-tokens-full-span: promoter and directly activates its transcription , and EZH2 expression is correlated with Myc expression in prostate cancer .tue2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='ezh2'] Gene_or_gene_producttKe2: trigger-arg-path: upregulates >nsubj [lemma='myc'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='myc'] controllertXe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj controllert)interceding-token ngrams: correlated withtGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='myc'] themet"interceding-token ngrams: cancer .t$interceding-token ngrams: correlatedtDe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj controllert3e2: args2Role-mention-ngram: upregulates CONTROLLEDtYe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj controller:Gene_or_gene_producttge1: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='myc'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='myc'] controller:Gene_or_gene_productt,interceding-token ngrams: is correlated witht(e2: args2Role-mention-ngram: upregulatest/interceding-token ngrams: promoter and directlyt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='myc'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='myc'] themetUe2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='myc'] controllertme1: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] theme:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] theme:Gene_or_gene_productt-interceding-token ngrams: with Myc expressiontxe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_activation >nsubj [lemma='myc'] Gene_or_gene_productt0interceding-token ngrams: and directly activatestee1: trigger-arg-path: binds >prep_to [lemma='promoter'] >nn [lemma='ezh2'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='myc'] theme:Gene_or_gene_producttinterceding-token ngrams: Myctde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='myc'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds:Binding >nsubj [lemma='myc'] Gene_or_gene_productt6e1: trigger-arg-path: binds >nsubj [lemma='myc'] themet[e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='ezh2'] controlled:Gene_or_gene_productt-interceding-token ngrams: correlated with MyctGe2: trigger-arg-path: upregulates:Positive_activation >nsubj controllertXe1: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] themetKe2: trigger-arg-path: upregulates >dobj >nn controlled:Gene_or_gene_productt@e2: trigger-arg-path: upregulates >dobj >nn Gene_or_gene_productt&interceding-token ngrams: and directlytGe1: trigger-arg-path: Binding >nsubj [lemma='myc'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='ezh2'] themet%interceding-token ngrams: in prostatet^e2: trigger-arg-path: Positive_activation >nsubj [lemma='myc'] controller:Gene_or_gene_producttQe2: trigger-arg-path: upregulates:Positive_activation >nsubj Gene_or_gene_productt(interceding-token ngrams: Myc expressionte2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='ezh2'] controlledtZe2: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='ezh2'] controlledt3e2: trigger-arg-path: upregulates >nsubj controllertIe2: trigger-arg-path: Positive_activation >nsubj [lemma='myc'] controllert+interceding-token ngrams: prostate cancer .tde2: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='ezh2'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj controller:Gene_or_gene_productt'interceding-token ngrams: activates itstae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='ezh2'] themet6e2: trigger-arg-path: upregulates >dobj >nn controlledtKe1: trigger-arg-path: bind >nsubj [lemma='mir-378-5p'] Gene_or_gene_producttKinterceding-tokens-full-span: and inhibits the expression of BRAF . KnowingtGe1: trigger-arg-path: bind >prep_to [lemma='braf'] Gene_or_gene_producttUe1: trigger-arg-path: bind:Binding >prep_to [lemma='braf'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mir-378-5p'] themet8e1: trigger-arg-path: bind >prep_to [lemma='braf'] themetVe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mir-378-5p'] themetOe1: trigger-arg-path: bind:Binding >prep_to [lemma='braf'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: target of SHAREDt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='braf'] theme:Gene_or_gene_productt*interceding-token ngrams: and inhibits thetPe1: trigger-arg-path: Binding >prep_to [lemma='braf'] theme:Gene_or_gene_producttYe1: trigger-arg-path: bind:Binding >nsubj [lemma='mir-378-5p'] theme:Gene_or_gene_producttSe1: trigger-arg-path: bind:Binding >nsubj [lemma='mir-378-5p'] Gene_or_gene_productt?e1: trigger-arg-path: Binding >nsubj [lemma='mir-378-5p'] themetMe1: trigger-arg-path: bind >prep_to [lemma='braf'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mir-378-5p'] Gene_or_gene_producttQe1: trigger-arg-path: bind >nsubj [lemma='mir-378-5p'] theme:Gene_or_gene_productt!interceding-token ngrams: of BRAFtnsubj [lemma='mir-378-5p'] themet1interceding-token ngrams: inhibits the expressiontae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='braf'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='braf'] Gene_or_gene_productt&interceding-token ngrams: inhibits thet]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mir-378-5p'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='braf'] themet(interceding-token ngrams: BRAF . KnowingtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='braf'] themetTe1: trigger-arg-path: Binding >nsubj [lemma='mir-378-5p'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bind:Binding >nsubj [lemma='mir-378-5p'] themet@e1: trigger-arg-path: bind:Binding >prep_to [lemma='braf'] themet#interceding-token ngrams: of BRAF .tke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='mir-378-5p'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='braf'] Gene_or_gene_productt,interceding-token ngrams: expression of BRAFtNe1: trigger-arg-path: Binding >nsubj [lemma='mir-378-5p'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='braf'] themetce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='mir-378-5p'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='braf'] theme:Gene_or_gene_productt"interceding-token ngrams: leukemict?e2: trigger-arg-path: stimulates >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] controlled:Gene_or_gene_productt0interceding-token ngrams: dependent induction oft?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='thrombopoietin'] controller:Gene_or_gene_productt9e2: ents2Label-mention-ngram: megakaryocyte proliferationt_e2: trigger-arg-path: stimulates:Positive_activation >nsubj [lemma='thrombopoietin'] controllertue2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='expression'] >nn [lemma='c-myc'] Gene_or_gene_productt1interceding-token ngrams: ERK dependent inductiontie2: trigger-arg-path: stimulates:Positive_activation >nsubj [lemma='thrombopoietin'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt%e2: ents2Label-mention-ngram: a majortpe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='thrombopoietin'] controllertinterceding-token ngrams: c-Myct^e2: trigger-arg-path: stimulates:Positive_activation >dobj >nn controlled:Gene_or_gene_productt)interceding-token ngrams: c-Myc regulatestme2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] Gene_or_gene_productt?e2: trigger-arg-path: stimulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] controlled:Gene_or_gene_productt=e2: ents2Label-mention-ngram: megakaryocyte proliferation andtde2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj >nn Gene_or_gene_productt.e2: args2Role-mention-ngram: differentiation ,t?e2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='expression'] >nn [lemma='c-myc'] controlled:Gene_or_gene_productt;e2: args2Role-mention-ngram: of megakaryocyte proliferationtZe2: trigger-arg-path: stimulates >dobj [lemma='expression'] >nn [lemma='c-myc'] controlledt:e2: ents2Label-mention-ngram: differentiation , stimulatest?interceding-tokens-full-span: in B-cell chronic lymphocytic leukemia , in which ERK dependent induction of c-Myc regulates leukemic cell proliferation .txe2: trigger-arg-path: stimulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='expression'] >nn [lemma='c-myc'] controlledtPe2: trigger-arg-path: stimulates:Positive_activation >nsubj Gene_or_gene_productt-e2: ents2Label-mention-ngram: major regulatort0e2: ents2Label-mention-ngram: major regulator oft6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , at2e2: args2Role-mention-ngram: and differentiation ,tUe2: trigger-arg-path: stimulates >nsubj [lemma='thrombopoietin'] Gene_or_gene_producttce2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] controlledt'interceding-token ngrams: leukemic cellt`e2: trigger-arg-path: stimulates >nsubj [lemma='thrombopoietin'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: and differentiationt/e2: ents2Label-mention-ngram: differentiation ,tPe2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: major regulator oftfe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='thrombopoietin'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: of megakaryocytet,interceding-token ngrams: of c-Myc regulatest,e2: args2Role-mention-ngram: major regulatortze2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='thrombopoietin'] Gene_or_gene_productt8e2: args2Role-mention-ngram: megakaryocyte proliferationtTe2: trigger-arg-path: Positive_activation >nsubj [lemma='thrombopoietin'] controllertae2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj Gene_or_gene_productt.e2: args2Role-mention-ngram: proliferation andtoe2: trigger-arg-path: stimulates >dobj [lemma='expression'] >nn [lemma='c-myc'] controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: megakaryocytet.e2: args2Role-mention-ngram: a major regulatort'interceding-token ngrams: ERK dependentt4e2: args2Role-mention-ngram: , stimulates CONTROLLEDt$e2: args2Role-mention-ngram: a majort2interceding-token ngrams: c-Myc regulates leukemictdobj >nn Gene_or_gene_productt-e2: ents2Label-mention-ngram: differentiationt'e2: ents2Label-mention-ngram: , a majort,interceding-token ngrams: induction of c-Myct#interceding-token ngrams: which ERKt?e2: ents2Label-mention-ngram: proliferation and differentiationt-e2: args2Role-mention-ngram: of megakaryocytetxe2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] controlled:Gene_or_gene_productt,interceding-token ngrams: regulates leukemict*e2: ents2Label-mention-ngram: , stimulatest>e2: args2Role-mention-ngram: proliferation and differentiationt5interceding-token ngrams: leukemic cell proliferationt*e2: args2Role-mention-ngram: proliferationt"interceding-token ngrams: of c-MyctJe2: trigger-arg-path: stimulates >dobj >nn controlled:Gene_or_gene_productt9e2: args2Role-mention-ngram: differentiation , stimulatest+e2: ents2Label-mention-ngram: megakaryocytet/e2: ents2Label-mention-ngram: proliferation andt0e2: args2Role-mention-ngram: and differentiationtdobj [lemma='expression'] >nn [lemma='c-myc'] controlledt1e2: ents2Label-mention-ngram: , stimulates SHAREDtie2: trigger-arg-path: Positive_activation >nsubj [lemma='thrombopoietin'] controller:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='c-myc'] controlledt&e2: args2Role-mention-ngram: , a majortqe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='thrombopoietin'] controller:Gene_or_gene_producttde2: trigger-arg-path: stimulates >dobj [lemma='expression'] >nn [lemma='c-myc'] Gene_or_gene_producttFe2: trigger-arg-path: stimulates:Positive_activation >nsubj controllert8e2: ents2Label-mention-ngram: regulator of megakaryocytet1interceding-token ngrams: regulates leukemic cellt5e2: trigger-arg-path: stimulates >dobj >nn controlledt-interceding-token ngrams: dependent inductiont^e2: trigger-arg-path: Positive_activation >nsubj [lemma='thrombopoietin'] Gene_or_gene_productt"e2: args2Role-mention-ngram: majort)e2: args2Role-mention-ngram: , stimulatest7e2: args2Role-mention-ngram: regulator of megakaryocytet+e2: ents2Label-mention-ngram: proliferationt-interceding-token ngrams: which ERK dependentt,e2: args2Role-mention-ngram: differentiationt\e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='thrombopoietin'] controllert#interceding-token ngrams: regulatest/e2: ents2Label-mention-ngram: a major regulatortWe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj controllertte2: trigger-arg-path: stimulates:Positive_activation >nsubj [lemma='thrombopoietin'] controller:Gene_or_gene_producttKe2: trigger-arg-path: stimulates >nsubj [lemma='thrombopoietin'] controllertIe2: trigger-arg-path: stimulates:Positive_activation >dobj >nn controlledtle2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: and differentiation ,t&interceding-token ngrams: in which ERKt[e2: trigger-arg-path: lemmatizedTrigger=stimulate >dobj >nn controlled:Gene_or_gene_productt[e2: trigger-arg-path: stimulates:Positive_activation >nsubj controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: enhanced and decreasedt&e1: ents2Label-mention-ngram: in vitrotTe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >dep controlled:Ubiquitinationt,e1: ents2Label-mention-ngram: vitro reactiont?e2: trigger-arg-path: decreased >dobj controlled:UbiquitinationtEe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj Ubiquitinationtke1: trigger-arg-path: Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] Ubiquitinationtpe1: trigger-arg-path: enhanced:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controllertUe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj controlledt4e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 1t?e2: trigger-arg-path: decreased >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controller:Gene_or_gene_producttQinterceding-tokens-full-span: . In a cell system , overexpression or depletion oft interceding-token ngrams: systemtqe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] UbiquitinationtYe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj >dep controlledt+e1: ents2Label-mention-ngram: enhanced Mdm2tDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and beta-arrestint+e1: ents2Label-mention-ngram: Mdm2 mediatedt;e1: ents2Label-mention-ngram: reaction GENE_OR_GENE_PRODUCTtCe1: trigger-arg-path: enhanced >dobj >dep controlled:Ubiquitinationt1interceding-token ngrams: system , overexpressiont'interceding-token ngrams: cell system ,t?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: Mdm2tne2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj [lemma='ubiquitination'] controlledtNe1: trigger-arg-path: Positive_regulation >dobj >dep controlled:Ubiquitinationte2: trigger-arg-path: Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT 1 enhancedtle2: trigger-arg-path: decreased:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtde2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj controlled:UbiquitinationtCe1: trigger-arg-path: Positive_regulation >dobj >dep Ubiquitinationtinterceding-token ngrams: In at;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhancedt2e2: ents2Label-mention-ngram: and decreased SHAREDt)e2: args2Role-mention-ngram: enhanced andt)e2: args2Role-mention-ngram: CONTROLLER 1tXe2: trigger-arg-path: decreased:Negative_regulation >nsubj >prep_of Gene_or_gene_productt interceding-token ngrams: a celltEe1: ents2Label-mention-ngram: and beta-arrestin co-immunoprecipitatedtIe2: trigger-arg-path: decreased >dobj [lemma='ubiquitination'] controlledt2e1: ents2Label-mention-ngram: Mdm2 mediated SHAREDt-e1: ents2Label-mention-ngram: with the IGF-1Rt^e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='ubiquitination'] Ubiquitinationthe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj >dep controlled:Ubiquitinationt|e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controllertte2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttae2: trigger-arg-path: decreased:Negative_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt|e1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlled:Ubiquitinationt`e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of controller:Gene_or_gene_producttNe2: trigger-arg-path: decreased:Negative_regulation >nsubj >prep_of controllert,e1: ents2Label-mention-ngram: the IGF-1R andt'e1: ents2Label-mention-ngram: and in ant?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlledt'e2: args2Role-mention-ngram: 1 enhancedt+interceding-token ngrams: overexpression ortDe1: ents2Label-mention-ngram: reaction GENE_OR_GENE_PRODUCT enhancedtMe2: trigger-arg-path: decreased >dobj [lemma='ubiquitination'] UbiquitinationtPe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj controlled:UbiquitinationtLe1: trigger-arg-path: enhanced:Positive_regulation >dobj >dep Ubiquitinationt$e1: ents2Label-mention-ngram: IGF-1Rt5e1: args2Role-mention-ngram: Mdm2 mediated CONTROLLEDtDe2: trigger-arg-path: decreased:Negative_regulation >dobj controlledt/e1: ents2Label-mention-ngram: in vitro reactionte1: trigger-arg-path: enhanced:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlled:Ubiquitinationtve1: trigger-arg-path: Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlled:Ubiquitinationt8e1: trigger-arg-path: enhanced >dobj >dep Ubiquitinationt5e1: args2Role-mention-ngram: CONTROLLER enhanced Mdm2t#e1: ents2Label-mention-ngram: an int%interceding-token ngrams: cell systemt#e1: ents2Label-mention-ngram: in ant?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: an in vitrot$e1: ents2Label-mention-ngram: and int}e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of Gene_or_gene_producttSe2: trigger-arg-path: decreased:Negative_regulation >dobj controlled:Ubiquitinationt interceding-token ngrams: . In at=e2: ents2Label-mention-ngram: decreased SHARED ubiquitinationtue2: trigger-arg-path: decreased >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] Gene_or_gene_producttte1: trigger-arg-path: enhanced:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] Ubiquitinationte2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controllert?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlled:Ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: enhanced and decreasedt#e1: ents2Label-mention-ngram: vitrot`e1: trigger-arg-path: enhanced >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] Ubiquitinationt3e1: args2Role-mention-ngram: enhanced Mdm2 mediatedtue2: trigger-arg-path: Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controllert"interceding-token ngrams: system ,t+e1: ents2Label-mention-ngram: IGF-1R and int(e2: ents2Label-mention-ngram: 1 enhancedt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] UbiquitinationtZe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='ubiquitination'] controlledt*e1: args2Role-mention-ngram: Mdm2 mediatedt'interceding-token ngrams: a cell systemt4e1: ents2Label-mention-ngram: enhanced Mdm2 mediatedt*e1: args2Role-mention-ngram: enhanced Mdm2t?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: decreased CONTROLLEDt_e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >prep_of controllert&interceding-token ngrams: or depletiontge1: trigger-arg-path: Positive_regulation >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlledtIe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >dep Ubiquitinationt,e2: ents2Label-mention-ngram: 1 enhanced andt(e1: ents2Label-mention-ngram: IGF-1R andt(e1: ents2Label-mention-ngram: the IGF-1Rt!e1: args2Role-mention-ngram: Mdm2t@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhanced Mdm2tie2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtce2: trigger-arg-path: decreased:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt#interceding-token ngrams: In a celltEe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >dep controlledt/e1: ents2Label-mention-ngram: and beta-arrestint5interceding-token ngrams: overexpression or depletiontHe1: trigger-arg-path: enhanced:Positive_regulation >dobj >dep controlledtre2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt)interceding-token ngrams: or depletion oft-interceding-token ngrams: , overexpression ortke2: trigger-arg-path: decreased >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controllertDe2: trigger-arg-path: decreased >nsubj >prep_of Gene_or_gene_productt+e2: args2Role-mention-ngram: 1 enhanced andtme1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlledt*e2: ents2Label-mention-ngram: enhanced andt:e2: trigger-arg-path: decreased >nsubj >prep_of controllert5e2: args2Role-mention-ngram: and decreased CONTROLLEDtXe2: trigger-arg-path: decreased >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt\e1: trigger-arg-path: enhanced >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlledtAe1: ents2Label-mention-ngram: vitro reaction GENE_OR_GENE_PRODUCTtdobj Ubiquitinationt+e1: ents2Label-mention-ngram: beta-arrestint4e1: trigger-arg-path: enhanced >dobj >dep controlledtOe2: trigger-arg-path: decreased >nsubj >prep_of controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >prep_of Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER 1 enhancedt?e2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] Gene_or_gene_producttFe1: ents2Label-mention-ngram: beta-arrestin co-immunoprecipitated witht?e2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='beta-arrestin'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: decreased SHAREDtke1: trigger-arg-path: enhanced >dobj [lemma='mdm2'] >dep [lemma='ubiquitination'] controlled:UbiquitinationtWe1: trigger-arg-path: enhanced:Positive_regulation >dobj >dep controlled:UbiquitinationtAe1: ents2Label-mention-ngram: beta-arrestin co-immunoprecipitatedt&e1: ents2Label-mention-ngram: reactiontYe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >dobj Ubiquitinationt]e2: trigger-arg-path: decreased:Negative_regulation >dobj [lemma='ubiquitination'] controlledtKe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of controllert&e1: ents2Label-mention-ngram: in an intHe2: trigger-arg-path: decreased:Negative_regulation >dobj Ubiquitinationt]e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj >dep Ubiquitinationt?e1: trigger-arg-path: Positive_regulation >dobj >dep controlledtOe2: trigger-arg-path: Binding >prep_between [lemma='raf1'] Gene_or_gene_productt5interceding-token ngrams: conformation formed betweent&interceding-token ngrams: conformationt interceding-token ngrams: formedtDe2: trigger-arg-path: interaction >prep_between [lemma='k-ra'] themet+interceding-token ngrams: between K-Ras andtse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_productt,interceding-token ngrams: that other factorst&interceding-token ngrams: and Raf1 maytae2: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_productt%interceding-token ngrams: play a rolet?interceding-tokens-full-span: is not entirely dependent on K-Ras , and that other factors , such as the irreversible conformation formed between K-Ras and Raf1 may play a role . This study sheds light on thet"interceding-token ngrams: light ont'interceding-token ngrams: other factorst+interceding-token ngrams: study sheds lightt interceding-token ngrams: role .t(interceding-token ngrams: K-Ras and Raf1tVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] themet3interceding-token ngrams: irreversible conformationtUe2: trigger-arg-path: Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt"interceding-token ngrams: a role .t"interceding-token ngrams: may playt(interceding-token ngrams: formed betweent)interceding-token ngrams: other factors ,tke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] theme:Gene_or_gene_productt%interceding-token ngrams: study shedst%interceding-token ngrams: role . Thist&interceding-token ngrams: light on thet$interceding-token ngrams: on K-Ras ,t(interceding-token ngrams: factors , suchtinterceding-token ngrams: playt@e2: trigger-arg-path: Binding >prep_between [lemma='raf1'] themetee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] Gene_or_gene_productt$interceding-token ngrams: may play atme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] themetSe2: trigger-arg-path: interaction >prep_between [lemma='k-ra'] Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_between [lemma='k-ra'] themet7interceding-token ngrams: the irreversible conformationtVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] themet/interceding-token ngrams: entirely dependent ont:interceding-token ngrams: irreversible conformation formedtSe2: trigger-arg-path: interaction >prep_between [lemma='raf1'] Gene_or_gene_productt(interceding-token ngrams: and that othertUe2: trigger-arg-path: Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] Gene_or_gene_productt,interceding-token ngrams: entirely dependentt0interceding-token ngrams: not entirely dependenttinterceding-token ngrams: Raf1t"interceding-token ngrams: and Raf1t&interceding-token ngrams: not entirelyt.interceding-token ngrams: formed between K-Rastme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] Gene_or_gene_productt"interceding-token ngrams: on K-Rastke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] theme:Gene_or_gene_productt,interceding-token ngrams: dependent on K-Rast interceding-token ngrams: a rolet-interceding-token ngrams: conformation formedt#interceding-token ngrams: factors ,t%interceding-token ngrams: K-Ras , andt(interceding-token ngrams: sheds light ont$interceding-token ngrams: that othertinterceding-token ngrams: shedst-interceding-token ngrams: as the irreversibletLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] themet*interceding-token ngrams: This study shedstse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt interceding-token ngrams: play at)interceding-token ngrams: is not entirelytDe2: trigger-arg-path: interaction >prep_between [lemma='raf1'] themet%interceding-token ngrams: such as thet&interceding-token ngrams: irreversiblet[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] themet"interceding-token ngrams: Raf1 mayt#interceding-token ngrams: K-Ras andtae2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt'interceding-token ngrams: between K-Rastinterceding-token ngrams: lighttKCSSPATH: ROOT >prep_in >vmod >xcomp >ccomp >nsubj >prep_of ++ ROOT >prep_ont^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] themet'interceding-token ngrams: Raf1 may playtYe2: trigger-arg-path: interaction >prep_between [lemma='raf1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] Gene_or_gene_productt*interceding-token ngrams: the irreversiblet%interceding-token ngrams: sheds lighttYe2: trigger-arg-path: interaction >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_between [lemma='k-ra'] Gene_or_gene_productt"interceding-token ngrams: entirelyt:e2: trigger-arg-path: Binding >prep_of [lemma='sp1'] themetCe1: trigger-arg-path: reduced:Negative_activation >nsubj controllertSe1: trigger-arg-path: Negative_activation >nsubj [lemma='MTM'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >prep_of [lemma='sp1'] Gene_or_gene_producttje1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >prep_of >prep_to >nn theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetwe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='MTM'] controller:Gene_or_gene_producttVe2: trigger-arg-path: binding:Binding >prep_of >prep_to >nn theme:Gene_or_gene_productt)interceding-token ngrams: transcription .t(interceding-token ngrams: indicating thetRe1: trigger-arg-path: reduced >nsubj [lemma='MTM'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: drasticallyt=e1: trigger-arg-path: reduced >nsubj [lemma='MTM'] controllert1interceding-token ngrams: EGFR gene transcriptiontXe1: trigger-arg-path: reduced:Negative_activation >nsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='MTM'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to >nn themetfe1: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='MTM'] controller:Gene_or_gene_productt-interceding-token ngrams: transcription . Thethe1: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlledtTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] themetWe2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: reduced:Negative_activation >dobj >nn controlled:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='MTM'] controllertSe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to >nn themetAe2: trigger-arg-path: binding:Binding >prep_of >prep_to >nn themetue1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: Binding >prep_of >prep_to >nn Gene_or_gene_productt-interceding-token ngrams: promoter activity ,t*interceding-token ngrams: , indicating thet!interceding-token ngrams: role oft0e1: args2Role-mention-ngram: drastically reducedtze1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activity'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttie2: trigger-arg-path: binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetPe2: trigger-arg-path: binding:Binding >prep_of >prep_to >nn Gene_or_gene_producttQe2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] Gene_or_gene_producttTe1: trigger-arg-path: reduced >dobj [lemma='activity'] >nn [lemma='egfr'] controlledt!interceding-token ngrams: in EGFRtQe1: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='MTM'] controllert?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] Gene_or_gene_producttie2: trigger-arg-path: Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetPe1: trigger-arg-path: reduced:Negative_activation >dobj >nn Gene_or_gene_productt`e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlledtre1: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] Gene_or_gene_producttdobj >nn Gene_or_gene_productt&interceding-token ngrams: in EGFR genetle1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='MTM'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] themet#interceding-token ngrams: of SP1 int+interceding-token ngrams: the critical rolet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_productt1interceding-token ngrams: indicating the criticalt'interceding-token ngrams: critical rolet/interceding-token ngrams: activity , indicatingt3e1: args2Role-mention-ngram: CONTROLLER drasticallytye1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlledt~e2: trigger-arg-path: Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_of [lemma='sp1'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='MTM'] controllert interceding-token ngrams: of SP1t~e2: trigger-arg-path: binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_producttie1: trigger-arg-path: reduced >dobj [lemma='activity'] >nn [lemma='egfr'] controlled:Gene_or_gene_productt}e1: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activity'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttinterceding-token ngrams: SP1tIe1: trigger-arg-path: Negative_activation >nsubj [lemma='MTM'] controllert3e1: args2Role-mention-ngram: reduced the CONTROLLEDtee1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activity'] >nn [lemma='egfr'] controlledtBe2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] themetFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT drastically reducedt9e2: trigger-arg-path: Binding >prep_of >prep_to >nn themetbe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to >nn Gene_or_gene_productt5e1: ents2Label-mention-ngram: drastically reduced thetie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of >prep_to >nn theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activity'] >nn [lemma='egfr'] Gene_or_gene_producttxe2: trigger-arg-path: binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt interceding-token ngrams: SP1 int%interceding-token ngrams: role of SP1tDe1: trigger-arg-path: reduced >nsubj controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to >nn theme:Gene_or_gene_productt9e2: trigger-arg-path: binding >prep_of >prep_to >nn themetae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] Gene_or_gene_productt.interceding-token ngrams: gene transcription .t>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT drasticallyt2e1: trigger-arg-path: reduced >dobj >nn controlledtqe2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] themet?e2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_producttOe2: trigger-arg-path: binding >prep_of [lemma='sp1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='MTM'] Gene_or_gene_productt/e1: trigger-arg-path: reduced >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt^e1: trigger-arg-path: Negative_activation >nsubj [lemma='MTM'] controller:Gene_or_gene_producttNe2: trigger-arg-path: binding >prep_of >prep_to >nn theme:Gene_or_gene_productt9e1: trigger-arg-path: reduced >nsubj Gene_or_gene_productt0e1: ents2Label-mention-ngram: reduced the SHAREDt+interceding-token ngrams: promoter activitytxe2: trigger-arg-path: Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt,interceding-token ngrams: gene transcriptiontce1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='MTM'] controller:Gene_or_gene_producttHe2: trigger-arg-path: binding >prep_of >prep_to >nn Gene_or_gene_producttGe1: trigger-arg-path: reduced >nsubj [lemma='MTM'] Gene_or_gene_productt4e1: args2Role-mention-ngram: drastically reduced thet1e1: ents2Label-mention-ngram: drastically reducedtMe1: trigger-arg-path: reduced:Negative_activation >nsubj Gene_or_gene_producttIe2: trigger-arg-path: binding >prep_of [lemma='sp1'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: drasticallyt#interceding-token ngrams: EGFR genetZe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of >prep_to >nn Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_productt%interceding-token ngrams: SP1 in EGFRtGe1: trigger-arg-path: reduced >dobj >nn controlled:Gene_or_gene_productt*interceding-token ngrams: critical role oft;e1: args2Role-mention-ngram: CONTROLLER drastically reducedt:e2: trigger-arg-path: binding >prep_of [lemma='sp1'] themetFe1: trigger-arg-path: reduced:Negative_activation >dobj >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sp1'] >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetvinterceding-tokens-full-span: promoter activity , indicating the critical role of SP1 in EGFR gene transcription . Thet^e1: trigger-arg-path: reduced >dobj [lemma='activity'] >nn [lemma='egfr'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-met'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] Simple_chemicaltpe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='trans-phosphorylation'] controlled:Phosphorylationt*interceding-token ngrams: supported by thet*interceding-token ngrams: that blockade oft+interceding-token ngrams: The critical rolet?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] Simple_chemicaltJe1: trigger-arg-path: Binding >nn [lemma='hgf'] theme:Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding >nn [lemma='c-met'] themet7e2: ents2Label-mention-ngram: oxidase function preventst7e1: trigger-arg-path: binding >nn [lemma='c-met'] themet*interceding-token ngrams: of NADPH oxidaset0interceding-token ngrams: mechanism is supportedt=e2: trigger-arg-path: prevents >nsubj >prep_of >nn controllertge2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >prep_of >nn Simple_chemicaltse2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='trans-phosphorylation'] controlled:Phosphorylationt1interceding-token ngrams: NADPH oxidase dependenttce2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='trans-phosphorylation'] controlledt/interceding-token ngrams: oxidase dependent ROSt/interceding-token ngrams: finding that blockadet\e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hgf'] theme:Gene_or_gene_productt!interceding-token ngrams: oxidasetDe1: trigger-arg-path: Binding >nn [lemma='hgf'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >prep_of >nn controller:Simple_chemicalt'interceding-token ngrams: that blockadetLe1: trigger-arg-path: binding >nn [lemma='c-met'] theme:Gene_or_gene_producttVe2: trigger-arg-path: prevents:Positive_regulation >nsubj >prep_of >nn Simple_chemicalt'interceding-token ngrams: dependent ROSt5e1: trigger-arg-path: Binding >nn [lemma='hgf'] themet6e2: ents2Label-mention-ngram: function prevents SHAREDt0interceding-token ngrams: crosstalk mechanism ist?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controllert)interceding-token ngrams: is supported byt&interceding-token ngrams: supported bytee2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='trans-phosphorylation'] Phosphorylationt.e2: ents2Label-mention-ngram: oxidase functiont?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controller:Simple_chemicaltse2: trigger-arg-path: prevents >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controllert"interceding-token ngrams: blockadet?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='trans-phosphorylation'] controlled:PhosphorylationtPe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlled:Phosphorylationt?interceding-tokens-full-span: . The critical role of NADPH oxidase dependent ROS production in this crosstalk mechanism is supported by the finding that blockade oftHe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn controllert,interceding-token ngrams: production in thist+interceding-token ngrams: in this crosstalkt7CSSPATH: ROOT >nsubj >appos >vmod >agent ++ ROOT >ccompt?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controllert%interceding-token ngrams: blockade oftIe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-met'] themet`e2: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='trans-phosphorylation'] controlledt%e2: args2Role-mention-ngram: functiont^e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-met'] theme:Gene_or_gene_productt:e2: ents2Label-mention-ngram: SHARED trans-phosphorylationtQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-met'] themetye2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='trans-phosphorylation'] Phosphorylationt~e2: trigger-arg-path: Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controllerthe2: trigger-arg-path: prevents:Positive_regulation >dobj [lemma='trans-phosphorylation'] Phosphorylationt5e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL oxidasetBe2: trigger-arg-path: prevents >nsubj >prep_of >nn Simple_chemicaltMe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn Simple_chemicalt+interceding-token ngrams: ROS production int'interceding-token ngrams: production int_e2: trigger-arg-path: prevents >dobj [lemma='trans-phosphorylation'] controlled:Phosphorylationtje2: trigger-arg-path: Positive_regulation >dobj [lemma='trans-phosphorylation'] controlled:Phosphorylationt-e2: args2Role-mention-ngram: oxidase functiont(interceding-token ngrams: this crosstalkt#interceding-token ngrams: supportedt3e2: ents2Label-mention-ngram: trans-phosphorylationtLe1: trigger-arg-path: binding:Binding >nn [lemma='hgf'] Gene_or_gene_productt9e2: args2Role-mention-ngram: function prevents CONTROLLEDtJe1: trigger-arg-path: binding >nn [lemma='hgf'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binding:Binding >nn [lemma='c-met'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hgf'] themet5e1: trigger-arg-path: binding >nn [lemma='hgf'] themetOe2: trigger-arg-path: prevents >dobj [lemma='trans-phosphorylation'] controlledt=e1: trigger-arg-path: binding:Binding >nn [lemma='hgf'] themetfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='c-met'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binding:Binding >nn [lemma='hgf'] theme:Gene_or_gene_productt8e2: args2Role-mention-ngram: CONTROLLER oxidase functiontSe2: trigger-arg-path: prevents:Positive_regulation >dobj controlled:PhosphorylationtGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hgf'] themet?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] Simple_chemicaltVe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hgf'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj Phosphorylationt&e2: ents2Label-mention-ngram: functiont2interceding-token ngrams: this crosstalk mechanismtde2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj controlled:Phosphorylationt&interceding-token ngrams: mechanism istFe1: trigger-arg-path: binding >nn [lemma='c-met'] Gene_or_gene_productt2interceding-token ngrams: dependent ROS productiontinterceding-token ngrams: NADPHt&interceding-token ngrams: is supportedt?e2: trigger-arg-path: prevents >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controller:Simple_chemicalt+interceding-token ngrams: oxidase dependenttxe2: trigger-arg-path: prevents >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] Simple_chemicaltMe2: trigger-arg-path: prevents >nsubj >prep_of >nn controller:Simple_chemicalt_e2: trigger-arg-path: Positive_regulation >dobj [lemma='trans-phosphorylation'] Phosphorylationt/e2: args2Role-mention-ngram: CONTROLLER oxidasetFe1: trigger-arg-path: Binding >nn [lemma='c-met'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controller:Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of >nn Simple_chemicalt^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hgf'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: oxidaset&interceding-token ngrams: The criticalt-interceding-token ngrams: crosstalk mechanismt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of >nn controllert'interceding-token ngrams: NADPH oxidaset?e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controller:Simple_chemicaltZe2: trigger-arg-path: Positive_regulation >dobj [lemma='trans-phosphorylation'] controlledt(interceding-token ngrams: by the findingtTe2: trigger-arg-path: prevents >dobj [lemma='trans-phosphorylation'] PhosphorylationtHe2: trigger-arg-path: prevents:Positive_regulation >dobj Phosphorylationtbe2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >nsubj >prep_of >nn controllert4e2: trigger-arg-path: prevents >dobj PhosphorylationtXe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='c-met'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=prevent:Positive_regulation >dobj [lemma='trans-phosphorylation'] controlledtLe1: trigger-arg-path: Binding >nn [lemma='c-met'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: function preventst(interceding-token ngrams: . The criticaltae2: trigger-arg-path: prevents:Positive_regulation >nsubj >prep_of >nn controller:Simple_chemicalt$e2: args2Role-mention-ngram: oxidaset7e1: trigger-arg-path: Binding >nn [lemma='c-met'] themet'interceding-token ngrams: role of NADPHtEe2: trigger-arg-path: lemmatizedTrigger=prevent >dobj Phosphorylationt?e2: trigger-arg-path: prevents >dobj controlled:PhosphorylationtTe1: trigger-arg-path: binding:Binding >nn [lemma='c-met'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=prevent >nsubj >prep_of >nn controller:Simple_chemicaltCe2: ents2Label-mention-ngram: prevents SHARED trans-phosphorylationtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hgf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: binding >nn [lemma='hgf'] Gene_or_gene_productt6e2: args2Role-mention-ngram: oxidase function preventst?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controller:Simple_chemicalt?e2: trigger-arg-path: prevents:Positive_regulation >nsubj [lemma='blockade'] >prep_of [lemma='function'] >nn [lemma='nadph'] controllert"interceding-token ngrams: of NADPHtQe2: trigger-arg-path: prevents:Positive_regulation >nsubj >prep_of >nn controllertXe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >nn controller:Simple_chemicalt>e1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT bindingt/e2: ents2Label-mention-ngram: function preventst>e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL oxidase functiont1e1: ents2Label-mention-ngram: salirasib failed tot\e2: trigger-arg-path: Positive_activation >prep_prior_to [lemma='igf2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlledtXe2: trigger-arg-path: Positive_activation >prep_prior_to controller:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt#interceding-token ngrams: salirasibt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controller:Gene_or_gene_producttRe2: trigger-arg-path: increased >prep_prior_to [lemma='igf2'] Gene_or_gene_producttCe2: trigger-arg-path: increased >prep_prior_to Gene_or_gene_productt.interceding-token ngrams: compared to controlst,interceding-token ngrams: and treatment witht.interceding-token ngrams: IGF2 stimulation didtze2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='expression'] >nn [lemma='phospho-erk'] Gene_or_gene_productt-e1: args2Role-mention-ngram: failed to reducet+e1: ents2Label-mention-ngram: preincubationt2e1: trigger-arg-path: reduce >dobj PhosphorylationtRe2: trigger-arg-path: increased:Positive_activation >dobj >nn Gene_or_gene_productt,interceding-token ngrams: . IGF2 stimulationt?e1: trigger-arg-path: lemmatizedTrigger=reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] Gene_or_gene_productt0e1: args2Role-mention-ngram: salirasib failed totpe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlledtHe2: trigger-arg-path: increased:Positive_activation >dobj >nn controlledt(interceding-token ngrams: with salirasibt,e1: ents2Label-mention-ngram: with salirasibt/e1: ents2Label-mention-ngram: and preincubationt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controllertTe2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to Gene_or_gene_producttke1: trigger-arg-path: reduce:Negative_regulation nsubj >prep_in >nn controller:Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylation andt?e1: trigger-arg-path: reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controller:Gene_or_gene_productt>e1: args2Role-mention-ngram: phosphorylation and preincubationtMe2: trigger-arg-path: Positive_activation >prep_prior_to Gene_or_gene_productt'e1: ents2Label-mention-ngram: to reducet]e2: trigger-arg-path: increased:Positive_activation >dobj >nn controlled:Gene_or_gene_productt%interceding-token ngrams: to controlst(interceding-token ngrams: not induce ERKt^e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to controllertse2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] Gene_or_gene_productt2interceding-token ngrams: phosphorylation comparedtTe1: trigger-arg-path: lemmatizedTrigger=reduce nsubj >prep_in >nn controllert]e2: trigger-arg-path: increased >prep_prior_to [lemma='igf2'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: salirasib failedt(interceding-token ngrams: treatment witht?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controllert/e1: args2Role-mention-ngram: preincubation witht)interceding-token ngrams: salirasib priortHe2: trigger-arg-path: increased >prep_prior_to [lemma='igf2'] controllert4interceding-token ngrams: induce ERK phosphorylationtYe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='phosphorylation'] controlledt+e1: ents2Label-mention-ngram: reduce SHAREDtbe2: trigger-arg-path: increased:Positive_activation >prep_prior_to controller:Gene_or_gene_productt?e1: trigger-arg-path: reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controllert-interceding-token ngrams: stimulation did nottprep_prior_to [lemma='igf2'] controller:Gene_or_gene_producttCe2: trigger-arg-path: Positive_activation >prep_prior_to controllertce1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj controlled:Phosphorylationtie1: trigger-arg-path: lemmatizedTrigger=reduce nsubj >prep_in >nn controller:Gene_or_gene_producttFe1: trigger-arg-path: reduce:Negative_regulation >dobj Phosphorylationt-interceding-token ngrams: ERK phosphorylationtke1: trigger-arg-path: reduce:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt\e2: trigger-arg-path: increased:Positive_activation >prep_prior_to [lemma='igf2'] controllertinterceding-token ngrams: IGF2t?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to [lemma='igf2'] controller:Gene_or_gene_productt"interceding-token ngrams: prior tot9e1: args2Role-mention-ngram: preincubation with salirasibtNe2: trigger-arg-path: increased >prep_prior_to controller:Gene_or_gene_producttRe2: trigger-arg-path: Positive_activation >prep_prior_to [lemma='igf2'] controllert,interceding-token ngrams: salirasib prior tot?e1: ents2Label-mention-ngram: phosphorylation and preincubationt7e1: args2Role-mention-ngram: CONTROLLER phosphorylationt?e2: trigger-arg-path: increased:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlled:Gene_or_gene_producttdobj >nn controlled:Gene_or_gene_productt interceding-token ngrams: . IGF2tWe2: trigger-arg-path: increased:Positive_activation >prep_prior_to Gene_or_gene_producttte2: trigger-arg-path: increased >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlled:Gene_or_gene_productt_e2: trigger-arg-path: increased >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlledt>e2: trigger-arg-path: increased >dobj >nn Gene_or_gene_productt)interceding-token ngrams: , and treatmentt0e1: ents2Label-mention-ngram: preincubation witht-e1: trigger-arg-path: reduce >dobj controlledt?e1: trigger-arg-path: reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] Gene_or_gene_producttLe1: trigger-arg-path: reduce nsubj >prep_in >nn Gene_or_gene_productt9e2: trigger-arg-path: increased >prep_prior_to controllertge2: trigger-arg-path: Positive_activation >prep_prior_to [lemma='igf2'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: with salirasib failedt-e1: args2Role-mention-ngram: salirasib failedtDe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj PhosphorylationtBe1: trigger-arg-path: reduce nsubj >prep_in >nn controllert$e1: ents2Label-mention-ngram: failedt*e1: args2Role-mention-ngram: preincubationt?e1: trigger-arg-path: lemmatizedTrigger=reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: increased SHAREDtie2: trigger-arg-path: increased >dobj [lemma='expression'] >nn [lemma='phospho-erk'] Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER increasedtfe2: trigger-arg-path: increased:Positive_activation >prep_prior_to [lemma='igf2'] Gene_or_gene_producttLe1: trigger-arg-path: reduce >dobj [lemma='phosphorylation'] Phosphorylationt&e1: args2Role-mention-ngram: failed tot1e1: args2Role-mention-ngram: to reduce CONTROLLEDt$interceding-token ngrams: induce ERKthe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to Gene_or_gene_productt?e1: trigger-arg-path: reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controllert(interceding-token ngrams: controls , andt#e1: args2Role-mention-ngram: failedt(interceding-token ngrams: did not inducet?interceding-tokens-full-span: . IGF2 stimulation did not induce ERK phosphorylation compared to controls , and treatment with salirasib prior tot;e1: args2Role-mention-ngram: CONTROLLER phosphorylation andtXe1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj Phosphorylationt&e1: args2Role-mention-ngram: salirasibt_e2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=reduce nsubj >prep_in >nn Gene_or_gene_productt2e1: args2Role-mention-ngram: with salirasib failedtYe2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to [lemma='igf2'] controllert*interceding-token ngrams: IGF2 stimulationtinterceding-token ngrams: priortre1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation nsubj >prep_in >nn Gene_or_gene_productt%interceding-token ngrams: compared tot6interceding-token ngrams: ERK phosphorylation comparedt}e2: trigger-arg-path: increased:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] Gene_or_gene_producttde1: trigger-arg-path: Negative_regulation nsubj >prep_in >nn controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to [lemma='igf2'] controller:Gene_or_gene_productt5interceding-token ngrams: phosphorylation compared tot$interceding-token ngrams: not inducetce2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to [lemma='igf2'] Gene_or_gene_producttQe1: trigger-arg-path: reduce:Negative_regulation >dobj controlled:Phosphorylationt3e1: args2Role-mention-ngram: and preincubation witht`e1: trigger-arg-path: reduce:Negative_regulation nsubj >prep_in >nn Gene_or_gene_productt'interceding-token ngrams: to controls ,tse2: trigger-arg-path: increased:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlledt.e1: args2Role-mention-ngram: and preincubationtie2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlledt-CSSPATH: ROOT >ccomp >xcomp ++ ROOT >conj_andtre1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt:e1: ents2Label-mention-ngram: preincubation with salirasibt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: and preincubation witht+e1: args2Role-mention-ngram: with salirasibtie1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='phosphorylation'] controlled:PhosphorylationtOe1: trigger-arg-path: lemmatizedTrigger=reduce >dobj controlled:PhosphorylationtOe1: trigger-arg-path: Negative_regulation nsubj >prep_in >nn controllertYe1: trigger-arg-path: Negative_regulation nsubj >prep_in >nn Gene_or_gene_producttWe1: trigger-arg-path: reduce nsubj >prep_in >nn controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: failed to reducetJe2: trigger-arg-path: lemmatizedTrigger=increase >prep_prior_to controllertCe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT increased SHAREDt4e2: trigger-arg-path: increased >dobj >nn controlledt}e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation nsubj >prep_in >nn controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: to reduce SHAREDtme2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to [lemma='igf2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlled:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_prior_to [lemma='igf2'] Gene_or_gene_productt`e1: trigger-arg-path: reduce:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt'interceding-token ngrams: and treatmenttVe1: trigger-arg-path: reduce:Negative_regulation nsubj >prep_in >nn controllert&e1: args2Role-mention-ngram: to reducet;e1: ents2Label-mention-ngram: reduce SHARED phosphorylationte2: incoming: nsubj >prep_in >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: failed tot0e1: args2Role-mention-ngram: phosphorylation andt$interceding-token ngrams: controls ,tGe1: trigger-arg-path: reduce >dobj [lemma='phosphorylation'] controlledt2interceding-token ngrams: treatment with salirasibt[e1: trigger-arg-path: reduce:Negative_regulation >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] Gene_or_gene_producttMe2: trigger-arg-path: increased:Positive_activation >prep_prior_to controllertme1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=reduce nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] controllert?e1: trigger-arg-path: reduce:Negative_regulation nsubj [lemma='increase'] >prep_in [lemma='phosphorylation'] >nn [lemma='erk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: salirasibt~e2: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] controlled:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='phosphorylation'] PhosphorylationtAe1: trigger-arg-path: reduce:Negative_regulation >dobj controlledt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='expression'] >nn [lemma='phospho-erk'] Gene_or_gene_productt=e1: trigger-arg-path: reduce >dobj controlled:Phosphorylationt)interceding-token ngrams: stimulation didt.interceding-token ngrams: with salirasib priortWe1: trigger-arg-path: reduce >dobj [lemma='phosphorylation'] controlled:PhosphorylationtGe1: trigger-arg-path: induces:Positive_activation >nsubj Generic_entityt/e1: args2Role-mention-ngram: including BNIP3L ,t)e1: ents2Label-mention-ngram: an increaset(e2: ents2Label-mention-ngram: and can bet#interceding-token ngrams: localizest(e1: args2Role-mention-ngram: , includingt/e1: ents2Label-mention-ngram: accompanied by ant+e1: args2Role-mention-ngram: by an increaset)e2: ents2Label-mention-ngram: OMM and cant/e1: ents2Label-mention-ngram: autophagy markerst?e1: trigger-arg-path: Positive_activation >nsubj Generic_entityt6e1: args2Role-mention-ngram: CONTROLLER is accompaniedt>e1: trigger-arg-path: induces >nsubj [lemma='this'] controllert*e1: ents2Label-mention-ngram: BNIP3L , andtMe1: trigger-arg-path: induces >nsubj [lemma='this'] controller:Generic_entitytXe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj Generic_entityt#e1: args2Role-mention-ngram: BNIP3Lt!e2: ents2Label-mention-ngram: OMMtae2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='lc3'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: accompanied byt$e1: args2Role-mention-ngram: markerstge1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='this'] Generic_entityt)e2: ents2Label-mention-ngram: is detectedtprep_with [lemma='lc3'] themet*e1: args2Role-mention-ngram: maturation oft5e1: args2Role-mention-ngram: maturation of CONTROLLEDt interceding-token ngrams: . Alsot interceding-token ngrams: Also ,t?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlled:Gene_or_gene_productt%e2: args2Role-mention-ngram: detectedt&e1: args2Role-mention-ngram: markers ,t(e2: ents2Label-mention-ngram: at the OMMt#e1: ents2Label-mention-ngram: by ant'e1: args2Role-mention-ngram: maturationtSe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='Rheb'] themet5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT istYe1: trigger-arg-path: Positive_activation >nsubj [lemma='this'] controller:Generic_entityt'e2: args2Role-mention-ngram: at the OMMtYe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='lc3'] Gene_or_gene_productt>e1: trigger-arg-path: induces >nsubj controller:Generic_entitytOe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='this'] controllertRe1: trigger-arg-path: induces:Positive_activation >nsubj controller:Generic_entityt(e1: ents2Label-mention-ngram: maturationt)interceding-token ngrams: to mitochondriatRe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='this'] controllert"interceding-token ngrams: . Also ,tSe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='this'] Generic_entityt+e1: args2Role-mention-ngram: an increase int3e1: args2Role-mention-ngram: and induces maturationt0e1: ents2Label-mention-ngram: including BNIP3L ,tBe1: trigger-arg-path: induces >nsubj [lemma='this'] Generic_entitytJe1: trigger-arg-path: Positive_activation >nsubj [lemma='this'] controllertNe1: trigger-arg-path: Positive_activation >nsubj [lemma='this'] Generic_entityt(interceding-token ngrams: mitochondria .t)e2: ents2Label-mention-ngram: the OMM andt(e2: args2Role-mention-ngram: OMM and cantje2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='lc3'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='lc3'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_activation >nsubj controller:Generic_entitytre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='this'] controller:Generic_entityt%e1: ents2Label-mention-ngram: markerstQe2: trigger-arg-path: Binding >prep_with [lemma='lc3'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: and induces maturationt(e1: args2Role-mention-ngram: an increasetce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='this'] controllert9e2: args2Role-mention-ngram: can be co-immunoprecipitatedt.e2: args2Role-mention-ngram: THEME is detectedtge2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='lc3'] theme:Gene_or_gene_productt{e1: trigger-arg-path: Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlled:Gene_or_gene_productt&e2: ents2Label-mention-ngram: detectedtae1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='this'] controller:Generic_entityt(e2: args2Role-mention-ngram: is detectedtOe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj controller:Generic_entityt/e1: args2Role-mention-ngram: , including BNIP3Lt%e2: ents2Label-mention-ngram: OMM andtde1: trigger-arg-path: induces >dobj [lemma='maturation'] >prep_of [lemma='lc3'] Gene_or_gene_productt)e1: args2Role-mention-ngram: in autophagyt2e1: args2Role-mention-ngram: increase in autophagyt'e1: ents2Label-mention-ngram: markers ,t e2: args2Role-mention-ngram: OMMt3e1: ents2Label-mention-ngram: increase in autophagyt+e1: ents2Label-mention-ngram: , and inducest;e1: ents2Label-mention-ngram: GENERIC_ENTITY is accompaniedt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT is detectedt.e1: args2Role-mention-ngram: is accompanied byt)CSSPATH: ROOT >conj_and ++ ROOT >conj_andt^e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='this'] controller:Generic_entitytke1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlledt)e1: ents2Label-mention-ngram: and inducest,e1: ents2Label-mention-ngram: is accompaniedt1e1: ents2Label-mention-ngram: autophagy markers ,t\e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='Rheb'] themetLe2: trigger-arg-path: Binding >nsubjpass [lemma='Rheb'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Generic_entityt+e1: args2Role-mention-ngram: accompanied byt(e2: args2Role-mention-ngram: the OMM andtZe1: trigger-arg-path: induces >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlledt%e1: args2Role-mention-ngram: BNIP3L ,t2e1: ents2Label-mention-ngram: maturation of SHAREDtxe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] Gene_or_gene_producttoe1: trigger-arg-path: induces >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: , including BNIP3Lt.e1: ents2Label-mention-ngram: including BNIP3Lt.e1: args2Role-mention-ngram: accompanied by ant=e2: trigger-arg-path: Binding >nsubjpass [lemma='Rheb'] themet1e1: ents2Label-mention-ngram: markers , includingt(interceding-token ngrams: that localizest)e1: ents2Label-mention-ngram: increase int,e1: ents2Label-mention-ngram: by an increaset)e2: ents2Label-mention-ngram: detected att:e2: args2Role-mention-ngram: be co-immunoprecipitated witht3interceding-token ngrams: localizes to mitochondriatRe2: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='lc3'] themetVe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='this'] Generic_entityt.e1: args2Role-mention-ngram: autophagy markerst&e1: ents2Label-mention-ngram: BNIP3L ,t6e2: ents2Label-mention-ngram: be co-immunoprecipitatedt;e2: ents2Label-mention-ngram: be co-immunoprecipitated witht%e2: ents2Label-mention-ngram: the OMMtye2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='Rheb'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: in autophagyt_e2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='lc3'] theme:Gene_or_gene_producttKe2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='Rheb'] themetfe1: trigger-arg-path: Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlledt)e1: ents2Label-mention-ngram: accompaniedtEinterceding-tokens-full-span: that localizes to mitochondria . Also ,te1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlledt+e1: ents2Label-mention-ngram: maturation oft&e1: args2Role-mention-ngram: includingt(e1: args2Role-mention-ngram: and inducestpe1: trigger-arg-path: Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: in autophagy markerst+interceding-token ngrams: that localizes totbe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='Rheb'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: induces maturationt$e2: args2Role-mention-ngram: OMM andtce2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='lc3'] themetpe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='lc3'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: induces maturationt-e2: ents2Label-mention-ngram: detected at thet,e1: ents2Label-mention-ngram: an increase int)e1: args2Role-mention-ngram: BNIP3L , andtse2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='Rheb'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: , includingt[e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='lc3'] themetJe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='lc3'] themet`e2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='Rheb'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] Gene_or_gene_productt(e1: args2Role-mention-ngram: increase int$e2: args2Role-mention-ngram: the OMMtne1: trigger-arg-path: induces:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlledtZe2: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='Rheb'] Gene_or_gene_productt0e1: args2Role-mention-ngram: autophagy markers ,tde2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='Rheb'] themet3e1: ents2Label-mention-ngram: induces maturation oft(e2: args2Role-mention-ngram: detected att5e2: args2Role-mention-ngram: be co-immunoprecipitatedt$e1: ents2Label-mention-ngram: BNIP3Ltue1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='maturation'] >prep_of [lemma='lc3'] Gene_or_gene_productt-e1: args2Role-mention-ngram: including BNIP3Lt'e1: ents2Label-mention-ngram: includingtxe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='lc3'] theme:Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj Generic_entitytke2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='Rheb'] Gene_or_gene_producttinterceding-token ngrams: Alsot,e2: args2Role-mention-ngram: detected at thet/e1: ents2Label-mention-ngram: is accompanied byt0e1: args2Role-mention-ngram: markers , includingt:e2: ents2Label-mention-ngram: can be co-immunoprecipitatedt'e2: args2Role-mention-ngram: and can bet?e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlled:Gene_or_gene_productt1e1: args2Role-mention-ngram: in autophagy markerst*e1: args2Role-mention-ngram: , and inducestKe2: trigger-arg-path: Binding >prep_with [lemma='lc3'] Gene_or_gene_productt&interceding-token ngrams: localizes tothe2: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='Rheb'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: is detected att+e1: args2Role-mention-ngram: is accompaniedtRe2: trigger-arg-path: Binding >nsubjpass [lemma='Rheb'] theme:Gene_or_gene_productt+interceding-token ngrams: to mitochondria .t?e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='maturation'] >prep_of [lemma='lc3'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: induces maturation oft(e1: args2Role-mention-ngram: accompaniedt"e1: args2Role-mention-ngram: by ant,e2: ents2Label-mention-ngram: is detected attqe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='Rheb'] theme:Gene_or_gene_productt-interceding-token ngrams: mitochondria . Alsot3e1: trigger-arg-path: induces >nsubj Generic_entityt#interceding-token ngrams: levels attPe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of Simple_chemicaltNe1: trigger-arg-path: increased >dobj >prep_of controlled:Gene_or_gene_productt#interceding-token ngrams: who foundt%interceding-token ngrams: depletion .t(interceding-token ngrams: EGFR levels attse1: trigger-arg-path: increased:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controlled:Gene_or_gene_producttDe1: ents2Label-mention-ngram: SIMPLE_CHEMICAL increased dimerizationtCe1: trigger-arg-path: increased >dobj >prep_of Gene_or_gene_producttinterceding-token ngrams: but ,t#interceding-token ngrams: came fromtMe1: trigger-arg-path: increased:Positive_activation >dobj >prep_of controlledtze1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicaltse1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicaltOe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated autophosphorylationt#interceding-token ngrams: al. , whotbe1: trigger-arg-path: increased:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controlledt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediatedtze1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt~e1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicaltie1: trigger-arg-path: Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlledt&interceding-token ngrams: support camet'interceding-token ngrams: , an increasetpe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlledt>e1: args2Role-mention-ngram: CONTROLLER increased dimerizationtinterceding-token ngrams: , whotse1: trigger-arg-path: Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: increased dimerization oft^e1: trigger-arg-path: increased:Positive_activation >nsubj >prep_of controller:Simple_chemicalthe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of Gene_or_gene_productt1interceding-token ngrams: of cholesterol enhancedt9e1: trigger-arg-path: increased >dobj >prep_of controlledt1e1: ents2Label-mention-ngram: dimerization of thet?e1: trigger-arg-path: increased:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlled:Gene_or_gene_productt3e1: args2Role-mention-ngram: increased dimerizationtde1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of Simple_chemicaltJe1: trigger-arg-path: increased >nsubj >prep_of controller:Simple_chemicalt/interceding-token ngrams: following cholesterolt*interceding-token ngrams: from Ushio-Fukait4e1: ents2Label-mention-ngram: increased dimerizationt(interceding-token ngrams: that depletiont%interceding-token ngrams: increase intWe1: trigger-arg-path: increased:Positive_activation >dobj >prep_of Gene_or_gene_producttde1: trigger-arg-path: increased >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert.interceding-token ngrams: cholesterol enhancedt6e1: args2Role-mention-ngram: increased dimerization oft}e1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicalt.interceding-token ngrams: Further support cametinterceding-token ngrams: , ant2interceding-token ngrams: depletion of cholesterolt(interceding-token ngrams: in contrast tot!interceding-token ngrams: , but ,t!interceding-token ngrams: Furthert0CSSPATH: ROOT  ++ ROOT >dobj >rcmod >ccomp >dobjt+interceding-token ngrams: that depletion oftNe1: trigger-arg-path: increased:Positive_activation >nsubj >prep_of controllert/interceding-token ngrams: came from Ushio-Fukaitxe1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert?e1: trigger-arg-path: increased >nsubj >prep_of Simple_chemicalt/interceding-token ngrams: membrane was observedt}e1: trigger-arg-path: increased:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] Gene_or_gene_productt_e1: trigger-arg-path: increased >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlledt(interceding-token ngrams: Ushio-Fukai ett9interceding-token ngrams: following cholesterol depletiont(interceding-token ngrams: in EGFR levelstoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of controller:Simple_chemicalt.interceding-token ngrams: found that depletiont7e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL increasedtIe1: trigger-arg-path: Positive_activation >nsubj >prep_of Simple_chemicaltTe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlled:Gene_or_gene_productt'interceding-token ngrams: , in contrastt0e1: args2Role-mention-ngram: dimerization of thet-interceding-token ngrams: from Ushio-Fukai ett,e1: args2Role-mention-ngram: dimerization oft^e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controlledt(interceding-token ngrams: an increase intie1: trigger-arg-path: increased >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicalt&interceding-token ngrams: was observedt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] Simple_chemicaltte1: trigger-arg-path: increased >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlled:Gene_or_gene_productt'interceding-token ngrams: contrast to ,tSe1: trigger-arg-path: increased:Positive_activation >nsubj >prep_of Simple_chemicalt(interceding-token ngrams: who found thattie1: trigger-arg-path: increased >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert&interceding-token ngrams: membrane wast?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert%interceding-token ngrams: Ushio-Fukaitne1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controllert-interceding-token ngrams: depletion . Furthert?interceding-tokens-full-span: , but , in contrast to , an increase in EGFR levels at the plasma membrane was observed following cholesterol depletion . Further support came from Ushio-Fukai et al. , who found that depletion of cholesterol enhancedt!interceding-token ngrams: to , antTe1: trigger-arg-path: Positive_activation >nsubj >prep_of controller:Simple_chemicalt,interceding-token ngrams: Ushio-Fukai et al.t%interceding-token ngrams: , who foundtinterceding-token ngrams: whot~e1: trigger-arg-path: Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlled:Gene_or_gene_productt%interceding-token ngrams: contrast tot!interceding-token ngrams: supporttinterceding-token ngrams: to ,t,interceding-token ngrams: observed followingt?e1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlled:Gene_or_gene_productt"interceding-token ngrams: enhancedtinterceding-token ngrams: camet[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >prep_of controller:Simple_chemicalt8interceding-token ngrams: observed following cholesterolt"interceding-token ngrams: but , int(interceding-token ngrams: of cholesterolt#interceding-token ngrams: . Furthert+interceding-token ngrams: . Further supportt1interceding-token ngrams: cholesterol depletion .t)interceding-token ngrams: Further supportt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicalt-interceding-token ngrams: plasma membrane wast%interceding-token ngrams: EGFR levelst+interceding-token ngrams: support came fromt'interceding-token ngrams: levels at thet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='dimerization'] >prep_of [lemma='egfr'] controlledt0interceding-token ngrams: was observed followingt*interceding-token ngrams: increase in EGFRtte1: trigger-arg-path: increased >nsubj [lemma='depletion'] >prep_of [lemma='cholesterol'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] controlledtqe1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] Phosphorylationt%interceding-token ngrams: Y55F mutanttje2: trigger-arg-path: reduced >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt.e1: args2Role-mention-ngram: and AU5-hSpry2 wtt"interceding-token ngrams: We foundtke1: trigger-arg-path: Positive_regulation nn [lemma='erk'] Phosphorylationt]e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn Phosphorylationt-e1: ents2Label-mention-ngram: AU5-hSpry2 wt ,tLe1: trigger-arg-path: promoted:Positive_regulation nn Phosphorylationte1: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] controlled:Phosphorylationt,e1: args2Role-mention-ngram: , or CONTROLLERte1: trigger: promotedtfe1: trigger-arg-path: Positive_regulation nn [lemma='erk'] controlledtdobj >nn Gene_or_gene_productt%interceding-token ngrams: signaling ,t4e1: ents2Label-mention-ngram: overexpressing HA-ERK2t!e1: args2Role-mention-ngram: wt ,txinterceding-tokens-full-span: Y55F mutant . We found that , in a similar way to the described effects on FGF signaling ,tGe1: trigger-arg-path: Positive_regulation conj_or >nn controllert[e1: trigger-arg-path: promoted nn [lemma='erk'] controlledt*interceding-token ngrams: on FGF signalingt interceding-token ngrams: on FGFt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert*e1: ents2Label-mention-ngram: by these cyPtQe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='hspry2'] controllertWe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn controlledt[e2: trigger-arg-path: reduced:Negative_activation >dobj >nn controlled:Gene_or_gene_productt*interceding-token ngrams: to the describedt1e2: ents2Label-mention-ngram: drastically reducedtve1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn controller:Gene_or_gene_producttFe1: trigger-arg-path: promoted conj_or >nn Gene_or_gene_producttPe1: trigger-arg-path: promoted:Positive_regulation conj_or >nn controllertMe1: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn controllert'interceding-token ngrams: the describedtve1: trigger-arg-path: Positive_regulation nn [lemma='erk'] controlled:Phosphorylationt#e1: args2Role-mention-ngram: cyP int8e1: trigger-arg-path: promoted nn Phosphorylationt+interceding-token ngrams: described effectst?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt%interceding-token ngrams: mutant . Wetconj_or >nn controllertTe1: trigger-arg-path: lemmatizedTrigger=promote nn controlled:Phosphorylationt'interceding-token ngrams: FGF signalingt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] controlled:Phosphorylationt?e1: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllertGe2: trigger-arg-path: reduced >dobj >nn controlled:Gene_or_gene_producttte1: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: CONTROLLER wtt,e1: ents2Label-mention-ngram: overexpressingtZe1: trigger-arg-path: promoted:Positive_regulation conj_or >nn Gene_or_gene_productt4e2: ents2Label-mention-ngram: wt drastically reducedt6e1: args2Role-mention-ngram: HeLa cells overexpressingtbe1: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: or CONTROLLERt|e1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert!e1: args2Role-mention-ngram: HeLatinterceding-token ngrams: FGFtve2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='hspry2'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: by theset+e1: args2Role-mention-ngram: and AU5-hSpry2tAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT wt drasticallyt!interceding-token ngrams: similart9e1: args2Role-mention-ngram: cells overexpressing HA-ERK2tae2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >nn Gene_or_gene_productt_e2: trigger-arg-path: reduced >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt`e1: trigger-arg-path: promoted nn [lemma='erk'] Phosphorylationt*e1: ents2Label-mention-ngram: these cyP int.e1: args2Role-mention-ngram: promoted by thesetWe1: trigger-arg-path: lemmatizedTrigger=promote conj_or >nn Gene_or_gene_productt2e1: ents2Label-mention-ngram: cells overexpressingt)e1: ents2Label-mention-ngram: promoted bytXe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controlledt'e1: args2Role-mention-ngram: HeLa cellst2e2: trigger-arg-path: reduced >dobj >nn controlledtVe2: trigger-arg-path: Negative_activation >nsubj [lemma='hspry2'] Gene_or_gene_productt'interceding-token ngrams: Y55F mutant .t&e1: ents2Label-mention-ngram: by thesetPe2: trigger-arg-path: reduced:Negative_activation >dobj >nn Gene_or_gene_productt#interceding-token ngrams: a similart8e2: ents2Label-mention-ngram: drastically reduced SHAREDt(e1: ents2Label-mention-ngram: HeLa cellstFe2: trigger-arg-path: reduced:Negative_activation >dobj >nn controlledt$interceding-token ngrams: effects ontGe1: trigger-arg-path: promoted:Positive_regulation nn controlledt$interceding-token ngrams: way to thetfe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='hspry2'] controller:Gene_or_gene_productt7e1: args2Role-mention-ngram: overexpressing HA-ERK2 andtee1: trigger-arg-path: promoted:Positive_regulation conj_or >nn controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: in HeLa cellst0e2: args2Role-mention-ngram: drastically reducedt?e1: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt?e1: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_producttoe1: trigger-arg-path: promoted:Positive_regulation nn [lemma='erk'] controlledt e1: args2Role-mention-ngram: cyPt?e1: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt/interceding-token ngrams: the described effectstTe2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='hspry2'] controllertee2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='hspry2'] controllert/e1: ents2Label-mention-ngram: and AU5-hSpry2 wtt6e1: ents2Label-mention-ngram: phosphorylation promotedt3e2: args2Role-mention-ngram: wt drastically reducedtze2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='hspry2'] controller:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=promote nn Phosphorylationtze2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt|e1: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert?e1: trigger-arg-path: promoted:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: AU5-hSpry2t8e1: ents2Label-mention-ngram: overexpressing HA-ERK2 andt%e1: args2Role-mention-ngram: promotedtDe1: trigger-arg-path: lemmatizedTrigger=promote nn controlledt6e2: args2Role-mention-ngram: CONTROLLER wt drasticallytCe1: trigger-arg-path: promoted nn controlled:Phosphorylationtke1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn Gene_or_gene_producttse2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt1e1: args2Role-mention-ngram: cells overexpressingt?e1: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: promotedtie2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt&interceding-token ngrams: in a similart@e2: trigger-arg-path: reduced >nsubj [lemma='hspry2'] controllert?e1: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: cyP in HeLatle1: trigger-arg-path: lemmatizedTrigger=promote nn [lemma='erk'] controlledtae2: trigger-arg-path: Negative_activation >nsubj [lemma='hspry2'] controller:Gene_or_gene_productt=e1: ents2Label-mention-ngram: SHARED phosphorylation promotedtae2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledtfe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='erk'] controlledt)e2: ents2Label-mention-ngram: drasticallyt(e1: args2Role-mention-ngram: promoted byt+e1: ents2Label-mention-ngram: AU5-hSpry2 wttNe1: trigger-arg-path: Positive_regulation nn controlled:Phosphorylationtie2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='hspry2'] controller:Gene_or_gene_productt;e2: args2Role-mention-ngram: drastically reduced CONTROLLEDt)e1: ents2Label-mention-ngram: HA-ERK2 andt)e1: args2Role-mention-ngram: by these cyPt$interceding-token ngrams: . We foundt9e1: ents2Label-mention-ngram: phosphorylation promoted byt(e2: args2Role-mention-ngram: drasticallyt,e1: ents2Label-mention-ngram: and AU5-hSpry2t'e1: args2Role-mention-ngram: AU5-hSpry2t7e1: ents2Label-mention-ngram: , or GENE_OR_GENE_PRODUCTt#interceding-token ngrams: that , int:e1: ents2Label-mention-ngram: cells overexpressing HA-ERK2t*e1: args2Role-mention-ngram: in HeLa cellstQe1: trigger-arg-path: Positive_regulation conj_or >nn Gene_or_gene_productt"e1: ents2Label-mention-ngram: wt ,t\e1: trigger-arg-path: Positive_regulation conj_or >nn controller:Gene_or_gene_producttCe1: trigger-arg-path: Positive_regulation nn Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: HeLa cells overexpressingt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn [lemma='erk'] Phosphorylationtoe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='hspry2'] Gene_or_gene_productt,e1: args2Role-mention-ngram: AU5-hSpry2 wt ,t'interceding-token ngrams: We found thatt~e2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt(interceding-token ngrams: similar way tot?e1: trigger-arg-path: Positive_regulation conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] controllert5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT wttLe2: trigger-arg-path: Negative_activation >nsubj [lemma='hspry2'] controllertke2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttke1: trigger-arg-path: promoted nn [lemma='erk'] controlled:PhosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn controlled:Gene_or_gene_productt)interceding-token ngrams: FGF signaling ,t+e1: args2Role-mention-ngram: overexpressingtae1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation conj_or >nn controllert/e1: ents2Label-mention-ngram: promoted by theset3e1: args2Role-mention-ngram: HA-ERK2 and AU5-hSpry2tUe2: trigger-arg-path: reduced >nsubj [lemma='hspry2'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: in HeLat$e1: args2Role-mention-ngram: in HeLat$e1: args2Role-mention-ngram: wt , ort"e1: ents2Label-mention-ngram: HeLat interceding-token ngrams: way tot!interceding-token ngrams: effectsthe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nn controlled:Phosphorylationt(interceding-token ngrams: effects on FGFtJe2: trigger-arg-path: reduced >nsubj [lemma='hspry2'] Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLED promotedt4e1: ents2Label-mention-ngram: HA-ERK2 and AU5-hSpry2t&e1: args2Role-mention-ngram: these cyPt(CSSPATH: ROOT >dobj >vmod ++ ROOT >ccompt3e1: trigger-arg-path: promoted nn controlledt.interceding-token ngrams: described effects ont%interceding-token ngrams: similar wayt*e1: args2Role-mention-ngram: AU5-hSpry2 wtt(e1: args2Role-mention-ngram: cyP in HeLat?e1: trigger-arg-path: promoted conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt)e1: args2Role-mention-ngram: these cyP int^e2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='hspry2'] Gene_or_gene_productt3e1: args2Role-mention-ngram: CONTROLLED promoted byt+e2: args2Role-mention-ngram: wt drasticallyt,e2: ents2Label-mention-ngram: wt drasticallyt(e1: args2Role-mention-ngram: HA-ERK2 andt%e1: ents2Label-mention-ngram: HA-ERK2t&interceding-token ngrams: found that ,t$e1: args2Role-mention-ngram: HA-ERK2t?e1: trigger-arg-path: lemmatizedTrigger=promote conj_or [lemma='mutant'] >nn [lemma='au5-hspry2'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: cyP intinterceding-token ngrams: Y55FtQe1: trigger-arg-path: promoted conj_or >nn controller:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn Gene_or_gene_productt!e1: ents2Label-mention-ngram: cyPtWe1: trigger-arg-path: promoted:Positive_regulation nn controlled:Phosphorylationt{e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt'interceding-token ngrams: a similar wayt%e1: ents2Label-mention-ngram: wt , ortUe2: trigger-arg-path: reduced >dobj [lemma='activation'] >nn [lemma='erk'] controlledtCe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >nn controlledtpe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: these cyPt interceding-token ngrams: , in at3e1: args2Role-mention-ngram: overexpressing HA-ERK2t;interceding-token ngrams: posttranscriptional modificationst7e2: args2Role-mention-ngram: agonists induce CONTROLLEDt/interceding-token ngrams: : PPAR-gamma directlyt)interceding-token ngrams: PTEN expressiontFe2: trigger-arg-path: induce >dobj >nn controlled:Gene_or_gene_producttJe1: trigger-arg-path: interaction >prep_between [lemma='ppar-gamma'] themet&interceding-token ngrams: : PPAR-gammatye1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ppar-gamma'] theme:Gene_or_gene_producttYe1: trigger-arg-path: interaction >prep_between [lemma='PTEN'] theme:Gene_or_gene_productt,interceding-token ngrams: also possible thatt6interceding-token ngrams: regulates PTEN transcriptiontZe2: trigger-arg-path: induce:Positive_activation >dobj >nn controlled:Gene_or_gene_productt,interceding-token ngrams: modifications , itt)interceding-token ngrams: unknown factorstce2: trigger-arg-path: induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt+interceding-token ngrams: transcription andt1interceding-token ngrams: because PTEN expressiontpe2: trigger-arg-path: Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] Gene_or_gene_producttYe2: trigger-arg-path: induce >dobj [lemma='overexpression'] >nn [lemma='pten'] controlledtfe2: trigger-arg-path: Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert/interceding-token ngrams: Furthermore , becauset,interceding-token ngrams: PTEN transcriptiontae1: trigger-arg-path: interaction:Binding >prep_between [lemma='PTEN'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='overexpression'] >nn [lemma='pten'] controlled:Gene_or_gene_productt'interceding-token ngrams: or PPAR-gammatqe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ppar-gamma'] theme:Gene_or_gene_productt&interceding-token ngrams: because PTENt)interceding-token ngrams: , regulate PTENt3interceding-token ngrams: transcription activity ortOe1: trigger-arg-path: Binding >prep_between [lemma='PTEN'] Gene_or_gene_producttDe1: trigger-arg-path: interaction >prep_between [lemma='PTEN'] themet?e2: trigger-arg-path: induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='PTEN'] themetee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTEN'] Gene_or_gene_producttSe1: trigger-arg-path: interaction >prep_between [lemma='PTEN'] Gene_or_gene_productt!interceding-token ngrams: is alsotFe2: trigger-arg-path: induce:Positive_activation >nsubj >nn controllert(interceding-token ngrams: expression cant,interceding-token ngrams: directly regulatest'interceding-token ngrams: modificationst"interceding-token ngrams: with itst1interceding-token ngrams: directly regulates PTENtue2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ppar-gamma'] themet,interceding-token ngrams: PTEN . Furthermoret9interceding-token ngrams: by inducing posttranscriptionalt4e2: ents2Label-mention-ngram: SHARED agonists inducet{e2: trigger-arg-path: Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlled:Gene_or_gene_productt7e2: args2Role-mention-ngram: CONTROLLER agonists inducet%e2: args2Role-mention-ngram: agonistst-e2: ents2Label-mention-ngram: SHARED agoniststne2: trigger-arg-path: induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt1e2: trigger-arg-path: induce >dobj >nn controlledt$interceding-token ngrams: , regulatet0interceding-token ngrams: transcription activitytEe2: trigger-arg-path: induce:Positive_activation >dobj >nn controlledt4e2: ents2Label-mention-ngram: agonists induce SHAREDt-interceding-token ngrams: PTEN expression cantinterceding-token ngrams: PTENt8interceding-token ngrams: PPAR-gamma regulates secondaryt[e2: trigger-arg-path: induce:Positive_activation >nsubj >nn controller:Gene_or_gene_productt&interceding-token ngrams: factors thatt#interceding-token ngrams: , in turnt5interceding-token ngrams: regulates secondary unknownt2interceding-token ngrams: regulated by interferingt0interceding-token ngrams: PTEN transcription andt$interceding-token ngrams: and and ortke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTEN'] theme:Gene_or_gene_productt#interceding-token ngrams: secondaryt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlled:Gene_or_gene_producttae1: trigger-arg-path: interaction:Binding >prep_between [lemma='ppar-gamma'] Gene_or_gene_productt$interceding-token ngrams: it is alsot4interceding-token ngrams: its transcription activityt%interceding-token ngrams: activity ortke2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert=interceding-token ngrams: posttranscriptional modifications ,t interceding-token ngrams: PTEN .tpe2: trigger-arg-path: Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllertfe2: trigger-arg-path: Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlledtwe2: trigger-arg-path: induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] Gene_or_gene_producttLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='PTEN'] themet)interceding-token ngrams: modifications ,t&e2: ents2Label-mention-ngram: agonistst.interceding-token ngrams: PPAR-gamma regulatestUe1: trigger-arg-path: Binding >prep_between [lemma='PTEN'] theme:Gene_or_gene_productt(interceding-token ngrams: or by inducingt(interceding-token ngrams: activity or bytYe1: trigger-arg-path: interaction >prep_between [lemma='ppar-gamma'] Gene_or_gene_productt1interceding-token ngrams: or PPAR-gamma regulatest*interceding-token ngrams: is also possiblet?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt(interceding-token ngrams: regulates PTENt+interceding-token ngrams: and or PPAR-gammate2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlledt-e2: ents2Label-mention-ngram: agonists inducet+interceding-token ngrams: expression can bet)CSSPATH: ROOT >xcomp >dobj ++ ROOT >ccomptke2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='overexpression'] >nn [lemma='pten'] controlledt-interceding-token ngrams: regulates secondarytOe2: trigger-arg-path: induce:Positive_activation >dobj >nn Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTEN'] theme:Gene_or_gene_productt[e1: trigger-arg-path: Binding >prep_between [lemma='ppar-gamma'] theme:Gene_or_gene_producttinterceding-token ngrams: or byt;e2: trigger-arg-path: induce >dobj >nn Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTEN'] themet interceding-token ngrams: can bet$interceding-token ngrams: PPAR-gammat]interceding-tokens-full-span: : PPAR-gamma directly regulates PTEN transcription and and or PPAR-gamma regulates secondary unknown factors that , in turn , regulate PTEN . Furthermore , because PTEN expression can be regulated by interfering with its transcription activity or by inducing posttranscriptional modifications , it is also possible thatt(interceding-token ngrams: , because PTENt interceding-token ngrams: and ort.interceding-token ngrams: interfering with itst?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ppar-gamma'] themet(interceding-token ngrams: factors that ,t0interceding-token ngrams: with its transcriptiont,e2: args2Role-mention-ngram: agonists inducet%interceding-token ngrams: by inducingt'interceding-token ngrams: regulate PTENtFe1: trigger-arg-path: Binding >prep_between [lemma='ppar-gamma'] themet?e2: trigger-arg-path: induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlled:Gene_or_gene_productt.interceding-token ngrams: unknown factors thatt+e2: ents2Label-mention-ngram: induce SHAREDtwe2: trigger-arg-path: induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt#interceding-token ngrams: in turn ,t{e2: trigger-arg-path: Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttce2: trigger-arg-path: induce >dobj [lemma='overexpression'] >nn [lemma='pten'] Gene_or_gene_producttme2: trigger-arg-path: induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert7interceding-token ngrams: PPAR-gamma directly regulatest*interceding-token ngrams: can be regulatedt-interceding-token ngrams: PPAR-gamma directlytYe2: trigger-arg-path: induce >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ppar-gamma'] Gene_or_gene_productt_e1: trigger-arg-path: interaction >prep_between [lemma='ppar-gamma'] theme:Gene_or_gene_productt+interceding-token ngrams: secondary unknownt'interceding-token ngrams: also possibletVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTEN'] themetse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ppar-gamma'] Gene_or_gene_producttme2: trigger-arg-path: induce:Positive_activation >dobj [lemma='overexpression'] >nn [lemma='pten'] controlledt3interceding-token ngrams: secondary unknown factorst#interceding-token ngrams: , becausetRe1: trigger-arg-path: interaction:Binding >prep_between [lemma='ppar-gamma'] themet/interceding-token ngrams: transcription and andt!interceding-token ngrams: and andtne2: trigger-arg-path: induce >dobj [lemma='overexpression'] >nn [lemma='pten'] controlled:Gene_or_gene_productt)interceding-token ngrams: regulate PTEN .t[e1: trigger-arg-path: interaction:Binding >prep_between [lemma='PTEN'] Gene_or_gene_productt)interceding-token ngrams: turn , regulatet6interceding-token ngrams: inducing posttranscriptionalt0e2: args2Role-mention-ngram: CONTROLLER agoniststPe2: trigger-arg-path: induce:Positive_activation >nsubj >nn Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTEN'] Gene_or_gene_producttDinterceding-token ngrams: inducing posttranscriptional modificationstge1: trigger-arg-path: interaction:Binding >prep_between [lemma='ppar-gamma'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controller:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='overexpression'] >nn [lemma='pten'] Gene_or_gene_productt-interceding-token ngrams: posttranscriptionaltUe1: trigger-arg-path: Binding >prep_between [lemma='ppar-gamma'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pi3k/akt/hsp90'] theme:Gene_or_gene_producttFe2: trigger-arg-path: enhances:Positive_regulation >dobj Generic_eventt+interceding-token ngrams: an IL-2-dependentt;e1: trigger-arg-path: interacts >nsubj [lemma='TERT'] themet!interceding-token ngrams: fashiontoe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3k/akt/hsp90'] theme:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhancestge2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='association'] controlled:Generic_eventtje2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='association'] controlledt-e2: ents2Label-mention-ngram: the associationtye2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='il-2'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='il-2'] Gene_or_gene_productt%interceding-token ngrams: . Notably ,tPe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='il-2'] controllert+interceding-token ngrams: fashion . Notablyt/e1: ents2Label-mention-ngram: directly with thet?e2: trigger-arg-path: enhances >nsubj [lemma='il-2'] controllertYe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='association'] Generic_eventtbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pi3k/akt/hsp90'] themetie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='TERT'] theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: also interacts directlyt3interceding-token ngrams: an IL-2-dependent fashiontme2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='association'] Generic_eventt*e2: ents2Label-mention-ngram: enhances thet[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='TERT'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='TERT'] theme:Gene_or_gene_productt(interceding-token ngrams: IL-2-dependenttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='TERT'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3k/akt/hsp90'] themetYe2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='association'] controlledtVe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='association'] controlledt^e1: trigger-arg-path: interacts >prep_with [lemma='pi3k/akt/hsp90'] theme:Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_with [lemma='pi3k/akt/hsp90'] Gene_or_gene_productt&interceding-token ngrams: Notably , wet]e2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='il-2'] Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='TERT'] themet4e2: args2Role-mention-ngram: CONTROLLER enhances thetAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also interactst4e2: args2Role-mention-ngram: enhances the CONTROLLEDtGe1: trigger-arg-path: Binding >prep_with [lemma='pi3k/akt/hsp90'] themet(interceding-token ngrams: mTORC1 pathwayt!interceding-token ngrams: NotablytJe1: trigger-arg-path: interacts >nsubj [lemma='TERT'] Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='TERT'] themetSe2: trigger-arg-path: enhances >dobj [lemma='association'] controlled:Generic_eventtLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='TERT'] themet0interceding-token ngrams: IL-2-dependent fashiont*interceding-token ngrams: / mTORC1 pathwayt?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhances theteinterceding-tokens-full-span: / mTORC1 pathway in an IL-2-dependent fashion . Notably , we found thattQe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pi3k/akt/hsp90'] themet)e2: args2Role-mention-ngram: enhances thetHe2: trigger-arg-path: enhances >dobj [lemma='association'] Generic_eventtEe2: trigger-arg-path: enhances >dobj [lemma='association'] controlledt"interceding-token ngrams: / mTORC1t0e2: args2Role-mention-ngram: CONTROLLER enhancestSe2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='il-2'] controllert=e2: trigger-arg-path: enhances >dobj controlled:Generic_eventtxe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='association'] controlled:Generic_eventt'interceding-token ngrams: pathway in antXe1: trigger-arg-path: interacts >prep_with [lemma='pi3k/akt/hsp90'] Gene_or_gene_productt+interceding-token ngrams: mTORC1 pathway int1e1: args2Role-mention-ngram: THEME also interactstQe2: trigger-arg-path: enhances:Positive_regulation >dobj controlled:Generic_eventt#interceding-token ngrams: fashion .tHe1: trigger-arg-path: Binding >nsubj [lemma='TERT'] Gene_or_gene_productt2interceding-token ngrams: IL-2-dependent fashion .tde2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='association'] controlled:Generic_eventt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='il-2'] controller:Gene_or_gene_productt.interceding-token ngrams: in an IL-2-dependenttCe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj Generic_eventthe2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='il-2'] controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='TERT'] Gene_or_gene_productt\e2: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='association'] Generic_eventtIe1: trigger-arg-path: interacts >prep_with [lemma='pi3k/akt/hsp90'] themet#interceding-token ngrams: . Notablytne2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='il-2'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj Generic_eventtJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='il-2'] controllertPe1: trigger-arg-path: interacts >nsubj [lemma='TERT'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3k/akt/hsp90'] Gene_or_gene_productt2e2: trigger-arg-path: enhances >dobj Generic_eventtTe2: trigger-arg-path: enhances >nsubj [lemma='il-2'] controller:Gene_or_gene_producttDe2: trigger-arg-path: enhances:Positive_regulation >nsubj controllert.e1: args2Role-mention-ngram: directly with thet\e1: trigger-arg-path: Binding >prep_with [lemma='pi3k/akt/hsp90'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='il-2'] controllertTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='TERT'] themetNe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj controlled:Generic_eventtNe2: trigger-arg-path: enhances:Positive_regulation >nsubj Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pi3k/akt/hsp90'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='il-2'] Gene_or_gene_productt`e1: trigger-arg-path: interacts:Binding >prep_with [lemma='pi3k/akt/hsp90'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: enhances the associationt5e1: ents2Label-mention-ngram: also interacts directlytRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='TERT'] Gene_or_gene_producttfe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pi3k/akt/hsp90'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='il-2'] controller:Gene_or_gene_producttYe2: trigger-arg-path: enhances:Positive_regulation >nsubj controller:Gene_or_gene_productt#interceding-token ngrams: Notably ,tbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlled:Generic_eventtNe1: trigger-arg-path: Binding >nsubj [lemma='TERT'] theme:Gene_or_gene_producttIe2: trigger-arg-path: enhances >nsubj [lemma='il-2'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of >nn Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp >nsubj controlled:Phosphorylationtae1: trigger-arg-path: Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlled:Gene_or_gene_producttKe1: trigger-arg-path: Positive_activation >prep_of >nn Gene_or_gene_producttinterceding-token ngrams: ECstke1: trigger-arg-path: Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] Gene_or_gene_producttre2: trigger-arg-path: Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] Phosphorylationtle1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlledt interceding-token ngrams: Grb2 ,t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlledt8e1: ents2Label-mention-ngram: SHARED mediated activationtBe1: trigger-arg-path: activation >prep_of >nn Gene_or_gene_producttBe2: trigger-arg-path: Positive_regulation >ccomp >nsubj controlledt!interceding-token ngrams: adaptortde1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='vegf'] controllert'interceding-token ngrams: we and otherst1interceding-token ngrams: activation promotes Rast?e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlled:PhosphorylationtMe1: trigger-arg-path: activation >prep_of >nn controlled:Gene_or_gene_productt\e1: trigger-arg-path: activation:Positive_activation >nn [lemma='vegf'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubj Phosphorylationtve1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] Gene_or_gene_producttVe1: trigger-arg-path: activation:Positive_activation >prep_of >nn Gene_or_gene_productt2interceding-token ngrams: association with adaptorte1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlled:Gene_or_gene_producttge1: trigger-arg-path: activation:Positive_activation >nn [lemma='vegf'] controller:Gene_or_gene_productt8e1: trigger-arg-path: activation >prep_of >nn controlledt`e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp >nsubj PhosphorylationtFe2: trigger-arg-path: induced >ccomp >nsubj controlled:Phosphorylationt:CSSPATH: ROOT >nsubjpass >prep_for >prep_in ++ ROOT >ccompt.interceding-token ngrams: adaptor protein Grb2t.interceding-token ngrams: via association withtze2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] Phosphorylationt)interceding-token ngrams: MAPK cascade int#interceding-token ngrams: in ECs istye1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='vegf'] controller:Gene_or_gene_productt2interceding-token ngrams: activity via associationt)interceding-token ngrams: . Although VEGFtOe2: trigger-arg-path: induced:Positive_regulation >ccomp >nsubj PhosphorylationtLe1: trigger-arg-path: activation:Positive_activation >prep_of >nn controlledtinterceding-token ngrams: VEGFtXe1: trigger-arg-path: activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlledt interceding-token ngrams: ECs istZe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='vegf'] Gene_or_gene_producttGe1: trigger-arg-path: Positive_activation >nn [lemma='vegf'] controllert&interceding-token ngrams: promotes Rastae1: trigger-arg-path: activation:Positive_activation >prep_of >nn controlled:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='cascade'] >nn [lemma='erk'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] Phosphorylationt}e2: trigger-arg-path: Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationt"interceding-token ngrams: , we andtHe1: trigger-arg-path: activation >nn [lemma='vegf'] Gene_or_gene_producttue2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlledt*interceding-token ngrams: Ras activity viat0interceding-token ngrams: Although VEGF receptort?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] Gene_or_gene_producttVe1: trigger-arg-path: Positive_activation >prep_of >nn controlled:Gene_or_gene_producttAe1: trigger-arg-path: Positive_activation >prep_of >nn controlledtinterceding-token ngrams: Grb2t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlled:PhosphorylationtZe2: trigger-arg-path: induced:Positive_regulation >ccomp >nsubj controlled:Phosphorylationt'interceding-token ngrams: Although VEGFt#interceding-token ngrams: debated .tre2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlledt,interceding-token ngrams: debated . Althought(interceding-token ngrams: cascade in ECst*interceding-token ngrams: is still debatedt.interceding-token ngrams: with adaptor proteint&interceding-token ngrams: with adaptortme1: trigger-arg-path: activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlled:Gene_or_gene_producttQe1: trigger-arg-path: Positive_activation >nn [lemma='vegf'] Gene_or_gene_producttae2: trigger-arg-path: induced >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlledt'interceding-token ngrams: still debatedtinterceding-token ngrams: stilltbe1: trigger-arg-path: activation >prep_of [lemma='cascade'] >nn [lemma='erk'] Gene_or_gene_productt!interceding-token ngrams: debatedtfe2: trigger-arg-path: induced >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] Phosphorylationt2interceding-token ngrams: VEGF receptor activationtve1: trigger-arg-path: Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlled:Gene_or_gene_productt&interceding-token ngrams: ECs is stillt*interceding-token ngrams: and others foundtPe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='vegf'] controllertGe2: trigger-arg-path: Positive_regulation >ccomp >nsubj Phosphorylationt)interceding-token ngrams: adaptor proteint/interceding-token ngrams: promotes Ras activitytJe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of >nn controlledt$interceding-token ngrams: cascade int"interceding-token ngrams: is stilltSe1: trigger-arg-path: activation >nn [lemma='vegf'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='vegf'] controller:Gene_or_gene_productt?e1: trigger-arg-path: activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlled:Gene_or_gene_productt interceding-token ngrams: in ECst?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] Phosphorylationt;e2: trigger-arg-path: induced >ccomp >nsubj PhosphorylationtRe1: trigger-arg-path: activation:Positive_activation >nn [lemma='vegf'] controllert&interceding-token ngrams: MAPK cascadet interceding-token ngrams: we andt'interceding-token ngrams: VEGF receptort~e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlledt^e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of >nn controlledtme2: trigger-arg-path: Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlledt$interceding-token ngrams: and otherstne1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='vegf'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of >nn Gene_or_gene_productt-interceding-token ngrams: activation promotest&interceding-token ngrams: others foundt?e2: trigger-arg-path: induced:Positive_regulation >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationt-interceding-token ngrams: receptor activationtqe2: trigger-arg-path: induced >ccomp [lemma='depend'] >nsubj [lemma='phosphorylation'] controlled:Phosphorylationt&interceding-token ngrams: protein Grb2t)interceding-token ngrams: via associationtse1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of >nn controlled:Gene_or_gene_productt\e1: trigger-arg-path: Positive_activation >nn [lemma='vegf'] controller:Gene_or_gene_productt#interceding-token ngrams: Grb2 , wet interceding-token ngrams: otherst.e1: args2Role-mention-ngram: activation of thet(interceding-token ngrams: protein Grb2 ,tRe2: trigger-arg-path: Positive_regulation >ccomp >nsubj controlled:Phosphorylationt_e1: trigger-arg-path: lemmatizedTrigger=activation >prep_of >nn controlled:Gene_or_gene_productt+interceding-token ngrams: others found thatt?interceding-tokens-full-span: MAPK cascade in ECs is still debated . Although VEGF receptor activation promotes Ras activity via association with adaptor protein Grb2 , we and others found thattje1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='cascade'] >nn [lemma='erk'] controlledt6interceding-token ngrams: receptor activation promotestJe2: trigger-arg-path: induced:Positive_regulation >ccomp >nsubj controlledt[e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >ccomp >nsubj controlledt>e1: trigger-arg-path: activation >nn [lemma='vegf'] controllertWe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubj controlled:Phosphorylationt)interceding-token ngrams: still debated .tNe2: trigger-arg-path: Binding >agent [lemma='mdm2'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='STAT-1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: inactivatedt/e2: args2Role-mention-ngram: otherwise be boundt{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: also binds thet2e2: args2Role-mention-ngram: bound and inactivatedt/interceding-token ngrams: promoter , repressingt)interceding-token ngrams: This repressiontee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='mdm2'] theme:Gene_or_gene_productt2interceding-token ngrams: This repression enhancest'interceding-token ngrams: stability andt3interceding-token ngrams: repressing its expressiontMe2: trigger-arg-path: Binding dobj [lemma='promoter'] >nn [lemma='mdm2'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >agent [lemma='mdm2'] themet)e2: ents2Label-mention-ngram: , which mayt-e2: args2Role-mention-ngram: may otherwise bet(e2: trigger-arg-path: bound >agent themet,e2: ents2Label-mention-ngram: inactivated byt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='mdm2'] Gene_or_gene_producttMe1: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='mdm2'] themet&e2: args2Role-mention-ngram: which maytJe1: trigger-arg-path: Binding >nsubj [lemma='STAT-1'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding agent Gene_or_gene_productt+interceding-token ngrams: the stability andt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding agent [lemma='mdm2'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >nsubj [lemma='STAT-1'] themet0e2: ents2Label-mention-ngram: otherwise be boundt8e2: trigger-arg-path: Binding agent Gene_or_gene_productt(e2: args2Role-mention-ngram: , which mayt)interceding-token ngrams: and activity oftFe2: trigger-arg-path: bound >agent [lemma='mdm2'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='STAT-1'] theme:Gene_or_gene_productt7e2: trigger-arg-path: bound >agent [lemma='mdm2'] themetue1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] Gene_or_gene_productt(e2: trigger-arg-path: bound dobj [lemma='promoter'] >nn [lemma='mdm2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] themet0e2: trigger-arg-path: bound:Binding >agent themetNe2: trigger-arg-path: bound:Binding >agent [lemma='mdm2'] Gene_or_gene_productt&interceding-token ngrams: , repressingtPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent [lemma='mdm2'] themetVe2: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='STAT-1'] Gene_or_gene_productt+interceding-token ngrams: expression . ThistWe2: trigger-arg-path: lemmatizedTrigger=bind >agent [lemma='mdm2'] Gene_or_gene_productt/e2: args2Role-mention-ngram: and inactivated bytVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent theme:Gene_or_gene_producttNe1: trigger-arg-path: binds >nsubj [lemma='STAT-1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: lemmatizedTrigger=bind >agent themetHe2: trigger-arg-path: lemmatizedTrigger=bind >agent Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >nsubj [lemma='STAT-1'] themet%e2: args2Role-mention-ngram: by THEMEt,e2: args2Role-mention-ngram: and inactivatedt0e2: args2Role-mention-ngram: which may otherwisetEe2: trigger-arg-path: bound:Binding >agent theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='STAT-1'] theme:Gene_or_gene_productt0e2: trigger-arg-path: bound:Binding dobj [lemma='promoter'] >nn [lemma='mdm2'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: may otherwisetUe1: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] themet0interceding-token ngrams: stability and activitytPe1: trigger-arg-path: Binding >nsubj [lemma='STAT-1'] theme:Gene_or_gene_productt=e2: trigger-arg-path: bound agent [lemma='mdm2'] themetAe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >agent themet+e1: args2Role-mention-ngram: also binds thet?e2: trigger-arg-path: bound:Binding dobj [lemma='promoter'] >nn [lemma='mdm2'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: otherwiset9e1: trigger-arg-path: binds >nsubj [lemma='STAT-1'] themetNe2: trigger-arg-path: lemmatizedTrigger=bind >agent theme:Gene_or_gene_productt\e1: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='mdm2'] Gene_or_gene_productt(interceding-token ngrams: repressing itst$interceding-token ngrams: repressingt(interceding-token ngrams: its expressiont*e2: trigger-arg-path: Binding >agent themet^e1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: bound and inactivatedt0interceding-token ngrams: enhances the stabilityt'interceding-token ngrams: the stabilityt*interceding-token ngrams: , repressing itst'e2: ents2Label-mention-ngram: bound andtLe2: trigger-arg-path: bound >agent [lemma='mdm2'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: bound andt,CSSPATH: ROOT  ++ ROOT >dobj >prep_of >rcmodt%e2: args2Role-mention-ngram: be boundtPe1: trigger-arg-path: binds:Binding >nsubj [lemma='STAT-1'] Gene_or_gene_productt)e2: args2Role-mention-ngram: be bound andt&e2: args2Role-mention-ngram: otherwiset.e2: ents2Label-mention-ngram: may otherwise betKe2: trigger-arg-path: bound agent theme:Gene_or_gene_producttde1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: inactivated by SHAREDt)e2: ents2Label-mention-ngram: inactivatedtSe2: trigger-arg-path: bound:Binding agent [lemma='mdm2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: bound:Binding >agent Gene_or_gene_producttMe2: trigger-arg-path: bound:Binding nsubj [lemma='STAT-1'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='mdm2'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind agent theme:Gene_or_gene_productt{interceding-tokens-full-span: promoter , repressing its expression . This repression enhances the stability and activity oftGe2: trigger-arg-path: Binding nsubj [lemma='STAT-1'] themet?e2: trigger-arg-path: bound:Binding >agent [lemma='mdm2'] themet>e2: trigger-arg-path: bound:Binding dobj [lemma='promoter'] >nn [lemma='mdm2'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Binding >agent [lemma='mdm2'] Gene_or_gene_productt+interceding-token ngrams: . This repressiont^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='mdm2'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='STAT-1'] Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >nsubj [lemma='STAT-1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding >agent Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controller:Gene_or_gene_productt#e1: ents2Label-mention-ngram: usingtBe2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controllert>e2: trigger-arg-path: induced nsubj >prep_of >nn controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: PD98059t$e1: args2Role-mention-ngram: PD98059tFe1: trigger-arg-path: reduced >nsubj >prep_of >nn Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of >nn controller:Gene_or_gene_producttIe2: trigger-arg-path: induced nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controllert(e2: ents2Label-mention-ngram: SHARED S15t.e2: trigger-arg-path: induced nsubj >prep_of >nn controllert6e1: ents2Label-mention-ngram: activation using PD98059tGe2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controllertie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: reduced >nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controller:Gene_or_gene_productt'interceding-token ngrams: U0126 reducest?e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controller:Gene_or_gene_producttinterceding-token ngrams: U0126t?e1: trigger-arg-path: lemmatizedTrigger=reduce:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: induced SHARED S15t2e1: args2Role-mention-ngram: using PD98059 reducedtSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt+interceding-token ngrams: inhibition of ERKtZe2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controller:Gene_or_gene_productt,interceding-token ngrams: with U0126 reducest]e2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controllert0e1: args2Role-mention-ngram: PD98059 reduced thet+e1: ents2Label-mention-ngram: SHARED at S15tDe2: trigger-arg-path: induced nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controllertZe1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of >nn Gene_or_gene_productt-e1: ents2Label-mention-ngram: PD98059 reducedtee1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: S15tCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activation usingt8e1: args2Role-mention-ngram: CONTROLLER activation usingt]interceding-tokens-full-span: . In addition , inhibition of ERK activation with U0126 reducestWe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of >nn Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >prep_of >nn controllert'e1: ents2Label-mention-ngram: at S15 intTe2: trigger-arg-path: induced nsubj [lemma='inhibition'] >prep_of [lemma='activation'] >nn [lemma='erk'] controller:Gene_or_gene_productt/interceding-token ngrams: activation with U0126tce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of >nn controllertPe1: trigger-arg-path: reduced:Positive_regulation >nsubj >prep_of >nn controllertRe2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controllertWe2: trigger-arg-path: enhances:Negative_activation >nsubj >prep_of Gene_or_gene_productt-CSSPATH: ROOT >nsubj >rcmod ++ ROOT >conj_andtfe2: trigger-arg-path: enhances >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] Gene_or_gene_productt)interceding-token ngrams: the activity oft1e2: ents2Label-mention-ngram: SHARED enhances thet&interceding-token ngrams: activate CK2tXe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj >nn controlledt.interceding-token ngrams: mediated degradationt3e1: ents2Label-mention-ngram: not be phosphorylatedt*interceding-token ngrams: MAPK is requiredtoe2: trigger-arg-path: enhances:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] Gene_or_gene_productt%interceding-token ngrams: to activatet+interceding-token ngrams: order to activatet|e2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controller:Gene_or_gene_producttMe2: trigger-arg-path: enhances:Negative_activation >nsubj >prep_of controllert*e1: ents2Label-mention-ngram: mutants thattje1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] controlledtze2: trigger-arg-path: enhances:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlled:Gene_or_gene_productt+interceding-token ngrams: show a resistancetUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] Gene_or_gene_productt?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mutants thattse2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt%interceding-token ngrams: p38 MAPK ist"interceding-token ngrams: p38 MAPKtfe2: trigger-arg-path: enhances >dobj [lemma='tumor'] >nn [lemma='pml'] controlled:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controllertQe2: trigger-arg-path: enhances >dobj [lemma='tumor'] >nn [lemma='pml'] controlledtme1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] Phosphorylationt%interceding-token ngrams: required int)interceding-token ngrams: to activate CK2tNe1: trigger-arg-path: phosphorylated >agent [lemma='ck2'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] controllert)interceding-token ngrams: pharmacologicalt#interceding-token ngrams: process ,t4interceding-token ngrams: pharmacological inhibitiont3interceding-token ngrams: degradation and increasedt5interceding-token ngrams: increased tumor suppressivet'interceding-token ngrams: process , thet-interceding-token ngrams: and increased tumort)interceding-token ngrams: degradation andtpe2: trigger-arg-path: enhances:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controllert^e1: trigger-arg-path: phosphorylated nn [lemma='pml'] Phosphorylationt?interceding-tokens-full-span: show a resistance to ubiquitin mediated degradation and increased tumor suppressive functions . In this process , the activity of the p38 MAPK is required in order to activate CK2 , and pharmacological inhibition oft8interceding-token ngrams: and pharmacological inhibitiont(interceding-token ngrams: is required intQe2: trigger-arg-path: enhances:Negative_activation >dobj >nn Gene_or_gene_producttre1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] Phosphorylationt!interceding-token ngrams: MAPK istle2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='tumor'] >nn [lemma='pml'] Gene_or_gene_producttXe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] controllertCe2: trigger-arg-path: enhances >nsubj >prep_of Gene_or_gene_productt(interceding-token ngrams: activate CK2 ,t&interceding-token ngrams: the activitytwe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj >nn controlled:Gene_or_gene_productt8interceding-token ngrams: ubiquitin mediated degradationt#interceding-token ngrams: CK2 , andt+interceding-token ngrams: tumor suppressivetqe2: trigger-arg-path: enhances >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controller:Gene_or_gene_productt7interceding-token ngrams: pharmacological inhibition oftge2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controllert(interceding-token ngrams: this process ,t$interceding-token ngrams: resistancetbe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='tumor'] >nn [lemma='pml'] controlledt*e1: ents2Label-mention-ngram: that can nott?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] controlled:Phosphorylationt/interceding-token ngrams: suppressive functionstce1: trigger-arg-path: Positive_regulation nn [lemma='pml'] Phosphorylationthe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >nsubj >prep_of Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: enhances:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controller:Gene_or_gene_productt&interceding-token ngrams: a resistancet1interceding-token ngrams: resistance to ubiquitint)interceding-token ngrams: a resistance tot?e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controller:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylated >agent [lemma='ck2'] controller:Gene_or_gene_productt'interceding-token ngrams: resistance tot#interceding-token ngrams: functionstGe2: trigger-arg-path: enhances:Negative_activation >dobj >nn controlledt9e2: trigger-arg-path: enhances >nsubj >prep_of controllertNe2: trigger-arg-path: Negative_activation >nsubj >prep_of Gene_or_gene_producttinterceding-token ngrams: CK2tinterceding-token ngrams: CK2 ,tbe2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj >nn Gene_or_gene_productt}e1: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='pml'] controlled:Phosphorylationt-interceding-token ngrams: and pharmacologicaltIe1: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] controllert$e1: ents2Label-mention-ngram: not betee2: trigger-arg-path: enhances:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] Gene_or_gene_producttbe2: trigger-arg-path: enhances:Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt1interceding-token ngrams: suppressive functions .tne1: trigger-arg-path: Positive_regulation nn [lemma='pml'] controlled:Phosphorylationt2interceding-token ngrams: mediated degradation andt+interceding-token ngrams: required in ordert?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] Gene_or_gene_productt,interceding-token ngrams: ubiquitin mediatedt)interceding-token ngrams: In this processt'interceding-token ngrams: and increasedt%interceding-token ngrams: functions .t~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_producttie1: trigger-arg-path: phosphorylated nn [lemma='pml'] controlled:PhosphorylationtDe1: trigger-arg-path: phosphorylated >agent [lemma='ck2'] controllert\e2: trigger-arg-path: Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlledtTe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of Gene_or_gene_producttqe2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='tumor'] >nn [lemma='pml'] controlled:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of controllert^e1: trigger-arg-path: Positive_regulation nn [lemma='pml'] controlledt!interceding-token ngrams: the p38t[e2: trigger-arg-path: enhances >dobj [lemma='tumor'] >nn [lemma='pml'] Gene_or_gene_productt/interceding-token ngrams: to ubiquitin mediatedtfe2: trigger-arg-path: Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] Gene_or_gene_productt?e2: ents2Label-mention-ngram: enhances the GENE_OR_GENE_PRODUCTt&interceding-token ngrams: the p38 MAPKtYe1: trigger-arg-path: phosphorylated nn [lemma='pml'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controller:Gene_or_gene_productt)interceding-token ngrams: increased tumortSe1: trigger-arg-path: Positive_regulation >agent [lemma='ck2'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: mutants that cantve2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlledt\e2: trigger-arg-path: enhances >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] controllert2e1: ents2Label-mention-ngram: be phosphorylated byt5interceding-token ngrams: tumor suppressive functionst(interceding-token ngrams: , the activitytNe2: trigger-arg-path: enhances >nsubj >prep_of controller:Gene_or_gene_productt interceding-token ngrams: show atoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] Phosphorylationt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mutantst!interceding-token ngrams: processtje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck2'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: mutantst(interceding-token ngrams: functions . Int?e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlled:Gene_or_gene_producttme1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck2'] controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='pml'] controlledtse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck2'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED enhancest$interceding-token ngrams: of the p38t/interceding-token ngrams: , and pharmacologicalt_e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of controller:Gene_or_gene_producttDe2: trigger-arg-path: Negative_activation >nsubj >prep_of controllert(e1: ents2Label-mention-ngram: can not betze1: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='pml'] controlled:Phosphorylationt&interceding-token ngrams: to ubiquitint&e1: ents2Label-mention-ngram: that cantYe2: trigger-arg-path: Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt&interceding-token ngrams: this processtze2: trigger-arg-path: enhances:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ck2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=enhance:Negative_activation >nsubj >prep_of controllert/e1: ents2Label-mention-ngram: be phosphorylatedtqe2: trigger-arg-path: Negative_activation >dobj [lemma='tumor'] >nn [lemma='pml'] controlled:Gene_or_gene_productt\e2: trigger-arg-path: enhances:Negative_activation >dobj >nn controlled:Gene_or_gene_productt?interceding-tokens-full-span: , and S734 phosphorylation of EZH2 reduces PRC2 assembly , EZH2 stability , and cell death in neurons .t1interceding-token ngrams: S734 phosphorylation oft.interceding-token ngrams: S734 phosphorylationt2interceding-token ngrams: and S734 phosphorylationt$interceding-token ngrams: , and S734t"interceding-token ngrams: and S734tinterceding-token ngrams: S734tde2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='tet2'] controllertZe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tet2'] Gene_or_gene_producttZe1: trigger-arg-path: interact:Binding >prep_with [lemma='ogt'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tet2'] themetye2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='tet2'] controller:Gene_or_gene_producttre2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] Gene_or_gene_producttTe2: trigger-arg-path: promotes >dobj [lemma='activity'] >nn [lemma='ogt'] controlledtprep_with [lemma='ogt'] themet_e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlledt=e1: trigger-arg-path: interact >prep_with [lemma='ogt'] themetfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ogt'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tet2'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tet2'] theme:Gene_or_gene_productt}e2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlled:Gene_or_gene_productt(e1: args2Role-mention-ngram: THEME and 3tQe1: trigger-arg-path: interact:Binding >nsubj [lemma='tet2'] Gene_or_gene_producttSe2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='tet2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tet2'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: 3 directlyt_e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj Gene_or_gene_producttte2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlled:Gene_or_gene_producttOe1: trigger-arg-path: interact >nsubj [lemma='tet2'] theme:Gene_or_gene_producttBe1: trigger-arg-path: interact:Binding >nsubj [lemma='tet2'] themet4e2: ents2Label-mention-ngram: SHARED promotes SHAREDtRe1: trigger-arg-path: interact >prep_with [lemma='ogt'] theme:Gene_or_gene_producttIe2: trigger-arg-path: promotes >nsubj [lemma='tet2'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: SHARED and 3t'e1: args2Role-mention-ngram: 3 directlytDe2: trigger-arg-path: promotes:Positive_activation >nsubj controllertee2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activity'] >nn [lemma='ogt'] controlledt-e2: ents2Label-mention-ngram: SHARED promotest^e2: trigger-arg-path: promotes >dobj [lemma='activity'] >nn [lemma='ogt'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_with [lemma='ogt'] theme:Gene_or_gene_producttie2: trigger-arg-path: promotes >dobj [lemma='activity'] >nn [lemma='ogt'] controlled:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activity'] >nn [lemma='ogt'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: 3 directly interacttJe2: trigger-arg-path: Positive_activation >nsubj [lemma='tet2'] controllerthe2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='tet2'] controller:Gene_or_gene_producttWe1: trigger-arg-path: interact:Binding >nsubj [lemma='tet2'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_with [lemma='ogt'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_activation >nsubj [lemma='tet2'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlledt:e1: trigger-arg-path: interact >nsubj [lemma='tet2'] themet,e1: ents2Label-mention-ngram: and 3 directlytTe1: trigger-arg-path: interact:Binding >prep_with [lemma='ogt'] Gene_or_gene_producttLe1: trigger-arg-path: interact >prep_with [lemma='ogt'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ogt'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='tet2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlled:Gene_or_gene_producttYe2: trigger-arg-path: promotes:Positive_activation >nsubj controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ogt'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='tet2'] themetLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='tet2'] themetHe1: trigger-arg-path: Binding >nsubj [lemma='tet2'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ogt'] Gene_or_gene_productt0e1: args2Role-mention-ngram: 3 directly interactthe2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] controlledtIe1: trigger-arg-path: interact >nsubj [lemma='tet2'] Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >nsubj [lemma='tet2'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj controllertEe1: trigger-arg-path: interact:Binding >prep_with [lemma='ogt'] themetTe2: trigger-arg-path: promotes >nsubj [lemma='tet2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: promotes >nsubj [lemma='tet2'] controllert]e2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='tet2'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ogt'] themetee2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tet2'] controller:Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='tet2'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='activity'] >nn [lemma='ogt'] controlled:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ogt'] themetne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='tet2'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tet2'] controllertNe2: trigger-arg-path: promotes:Positive_activation >nsubj Gene_or_gene_productt+e1: args2Role-mention-ngram: and 3 directlytie2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='ogt'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: further increaset*e1: args2Role-mention-ngram: and OPN cellst@e2: trigger-arg-path: activates >dobj [lemma='c-raf'] controlledt2e2: ents2Label-mention-ngram: ultimately activatestIe2: trigger-arg-path: Positive_activation >nsubj [lemma='opn'] controllert+interceding-token ngrams: by immunoblottingt0e1: args2Role-mention-ngram: OPN cells displayedt3e1: ents2Label-mention-ngram: in phosphorylation oftDe1: trigger-arg-path: phosphorylation nsubj >nn controllert'interceding-token ngrams: analyses withtee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='c-raf'] controlledt'e2: args2Role-mention-ngram: ultimatelyt*interceding-token ngrams: antibody . ThesetYe1: trigger-arg-path: phosphorylation nsubj >nn controller:Gene_or_gene_productt6interceding-token ngrams: immunoblotting analyses withtze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='c-raf'] controlled:Gene_or_gene_producttNe1: trigger-arg-path: phosphorylation nsubj >nn Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='c-raf'] Gene_or_gene_producttRe1: trigger-arg-path: Positive_regulation nsubj >nn Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >dobj [lemma='c-raf'] controlled:Gene_or_gene_productt'e1: ents2Label-mention-ngram: OPN cellst'e1: ents2Label-mention-ngram: a furthert.e1: args2Role-mention-ngram: cells displayed atHe1: trigger-arg-path: Positive_regulation nsubj >nn controllert,e1: args2Role-mention-ngram: cells displayedt"e1: ents2Label-mention-ngram: lanet0e1: ents2Label-mention-ngram: in phosphorylationt,CSSPATH: ROOT >prep_in ++ ROOT >ccomp >advcltte1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn Gene_or_gene_productt*e1: ents2Label-mention-ngram: Figure ) andt%interceding-token ngrams: as measuredt"e1: ents2Label-mention-ngram: 2 atthe2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='opn'] controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: ultimatelyt-interceding-token ngrams: indicate that whilet?e1: trigger-arg-path: Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: at Ser338 (tTe2: trigger-arg-path: Positive_activation >dobj [lemma='c-raf'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: Thr202t,interceding-token ngrams: respective phosphot*e1: args2Role-mention-ngram: in CONTROLLEDt(e1: ents2Label-mention-ngram: Erk1 and 2t/e1: args2Role-mention-ngram: CONTROLLER and OPNt'e1: ents2Label-mention-ngram: in FiguretYe2: trigger-arg-path: activates:Positive_activation >dobj controlled:Gene_or_gene_productt}e1: trigger-arg-path: phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt-e1: args2Role-mention-ngram: further increasetde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='opn'] controllert&e1: ents2Label-mention-ngram: ( lane 4t0e1: args2Role-mention-ngram: displayed a furthert*e1: ents2Label-mention-ngram: and Erk1 andtJe2: trigger-arg-path: Positive_activation >dobj [lemma='c-raf'] controlledt/interceding-token ngrams: results indicate thatt]e2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='opn'] Gene_or_gene_productt0interceding-token ngrams: These results indicatetnsubj >nn Gene_or_gene_productt)e1: ents2Label-mention-ngram: in Figure )t"e1: ents2Label-mention-ngram: 4 int?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] controllertPe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='opn'] controllert-interceding-token ngrams: specific antibody .t?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controllert'e1: ents2Label-mention-ngram: at Thr202t!interceding-token ngrams: . Theset^e2: trigger-arg-path: Positive_activation >nsubj [lemma='opn'] controller:Gene_or_gene_productt)interceding-token ngrams: . These resultst$interceding-token ngrams: that whiletse1: trigger-arg-path: phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] controllertSe2: trigger-arg-path: Positive_activation >nsubj [lemma='opn'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: lane 4 intTe2: trigger-arg-path: activates >nsubj [lemma='opn'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: a further increaset1interceding-token ngrams: with respective phosphot$interceding-token ngrams: respectivet)e1: ents2Label-mention-ngram: 2 at Thr202t(interceding-token ngrams: immunoblottingt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controllert?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt$e1: args2Role-mention-ngram: furthert$e1: ents2Label-mention-ngram: ( lanet^e2: trigger-arg-path: activates:Positive_activation >dobj [lemma='c-raf'] Gene_or_gene_productt]e1: trigger-arg-path: Positive_regulation nsubj >nn controller:Gene_or_gene_producttinterceding-token ngrams: 204tNe2: trigger-arg-path: activates:Positive_activation >dobj Gene_or_gene_productt$e1: ents2Label-mention-ngram: FiguretJe2: trigger-arg-path: activates >dobj [lemma='c-raf'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: OPNtfe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='c-raf'] controlled:Gene_or_gene_productt/e1: ents2Label-mention-ngram: cells displayed at2e2: args2Role-mention-ngram: CONTROLLER ultimatelyt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn controllertnsubj [lemma='opn'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt$interceding-token ngrams: and 204 astIe2: trigger-arg-path: activates >nsubj [lemma='opn'] Gene_or_gene_productt!interceding-token ngrams: and 204t"interceding-token ngrams: analysest&e1: ents2Label-mention-ngram: Figure )tee2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='opn'] controller:Gene_or_gene_productt(interceding-token ngrams: as measured bytQe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='c-raf'] controlledt0e1: ents2Label-mention-ngram: a further increasetke1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn controller:Gene_or_gene_productt;e2: trigger-arg-path: activates >nsubj Gene_or_gene_productt&e1: args2Role-mention-ngram: displayedt*interceding-token ngrams: results indicatet)e1: ents2Label-mention-ngram: displayed atinterceding-token ngrams: Theset4interceding-token ngrams: measured by immunoblottingt)interceding-token ngrams: 204 as measuredt'interceding-token ngrams: These resultst(e1: ents2Label-mention-ngram: ) and Erk1t+e1: ents2Label-mention-ngram: and OPN cellst-e1: ents2Label-mention-ngram: cells displayedtGe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ultimately activatest`e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn Gene_or_gene_productt2interceding-token ngrams: analyses with respectivetVe1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn controllert1e1: ents2Label-mention-ngram: further increase int3interceding-token ngrams: phospho specific antibodyt&e1: ents2Label-mention-ngram: and 2 attEe2: trigger-arg-path: activates >dobj controlled:Gene_or_gene_productt$e1: ents2Label-mention-ngram: lane 4t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt)interceding-token ngrams: with respectivetTe2: trigger-arg-path: activates:Positive_activation >dobj [lemma='c-raf'] controlledt?e2: trigger-arg-path: activates >nsubj [lemma='opn'] controllerte1: ents2Label-mention-ngram: 4t+interceding-token ngrams: specific antibodyt1e1: ents2Label-mention-ngram: OPN cells displayedtme1: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: Ser338 (t5interceding-token ngrams: respective phospho specifict"interceding-token ngrams: indicatet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_producttUe2: trigger-arg-path: activates >dobj [lemma='c-raf'] controlled:Gene_or_gene_producttZe2: trigger-arg-path: activates:Positive_activation >nsubj controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: increase in phosphorylationt$e1: args2Role-mention-ngram: and OPNt$e1: ents2Label-mention-ngram: Ser338tye2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='opn'] controller:Gene_or_gene_productt4interceding-token ngrams: by immunoblotting analysest1e2: args2Role-mention-ngram: ultimately activatest?interceding-tokens-full-span: and 204 as measured by immunoblotting analyses with respective phospho specific antibody . These results indicate that whilet&e1: args2Role-mention-ngram: OPN cellst)e1: ents2Label-mention-ngram: 4 in Figuret interceding-token ngrams: 204 ast&e1: args2Role-mention-ngram: a furthertOe2: trigger-arg-path: activates:Positive_activation >nsubj Gene_or_gene_productt1interceding-token ngrams: immunoblotting analysest=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ultimatelyt(e1: args2Role-mention-ngram: displayed atSe2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='opn'] controllertne2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='opn'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: and Erk1twe1: trigger-arg-path: Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controllert e1: args2Role-mention-ngram: OPNt3e1: args2Role-mention-ngram: increase in CONTROLLEDt?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED at Ser338tie2: trigger-arg-path: activates:Positive_activation >dobj [lemma='c-raf'] controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='c-raf'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: displayedt%e1: ents2Label-mention-ngram: and OPNt+e1: ents2Label-mention-ngram: Ser338 ( lanet:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and OPNt'e1: ents2Label-mention-ngram: at Ser338t'interceding-token ngrams: indicate thattXe1: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn controllert1e1: ents2Label-mention-ngram: displayed a furthert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: further increase int?e1: trigger-arg-path: phosphorylation nsubj [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt%interceding-token ngrams: measured bytFe2: trigger-arg-path: activates >nsubj controller:Gene_or_gene_productt:e2: trigger-arg-path: activates >dobj Gene_or_gene_productt:e2: ents2Label-mention-ngram: phosphorylation promotes thet'e1: ents2Label-mention-ngram: serine 32t#interceding-token ngrams: ex vivo .tne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttle2: trigger-arg-path: promotes nsubj [lemma='rsk2'] controller:Positive_regulationtpe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controller:Positive_regulationtte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj Positive_regulationt4e2: args2Role-mention-ngram: CONTROLLER promotes thet9e2: ents2Label-mention-ngram: promotes the ubiquitinationt@e2: trigger-arg-path: promotes nsubj Positive_regulationtce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_productt e1: ents2Label-mention-ngram: 32tZe1: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='rsk2'] controller:Positive_regulationt\e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controllert}e2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='rsk2'] controller:Positive_regulationtwe2: trigger-arg-path: Positive_regulation nsubj [lemma='rsk2'] controller:Positive_regulationtQe2: trigger-arg-path: lemmatizedTrigger=promote nsubj Positive_regulationt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] Gene_or_gene_productt interceding-token ngrams: and extae2: trigger-arg-path: promotes nsubj [lemma='rsk2'] Positive_regulationt_e2: trigger-arg-path: promotes:Positive_regulation nsubj controller:Positive_regulationtEe1: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] controllertKe2: trigger-arg-path: promotes:Positive_regulation nsubj controllertJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rsk2'] controllert7e2: trigger-arg-path: promotes nsubj controllert?e2: trigger-arg-path: promotes:Positive_regulation nsubj [lemma='rsk2'] controller:Positive_regulationtue2: trigger-arg-path: promotes:Positive_regulation nsubj [lemma='rsk2'] Positive_regulationt}e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='rsk2'] controllertXe2: trigger-arg-path: promotes nsubj [lemma='rsk2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='rsk2'] Positive_regulationtie2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='rsk2'] controllertle2: trigger-arg-path: promotes:Positive_regulation nsubj [lemma='rsk2'] controllert*e1: ents2Label-mention-ngram: at serine 32t!interceding-token ngrams: ex vivotHe2: trigger-arg-path: lemmatizedTrigger=promote nsubj controllertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttOe1: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylation promotest=e2: ents2Label-mention-ngram: SHARED phosphorylation promotest4interceding-tokens-full-span: in vitro and ex vivo .tVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] controllertre2: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='rsk2'] Positive_regulationtinterceding-token ngrams: ext\e2: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Positive_regulationte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt%interceding-token ngrams: and ex vivot_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttTe2: trigger-arg-path: promotes:Positive_regulation nsubj Positive_regulationtle2: trigger-arg-path: Positive_regulation nsubj [lemma='rsk2'] Positive_regulationtce2: trigger-arg-path: Positive_regulation nsubj [lemma='rsk2'] controllertke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] controllertje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] controllertKe2: trigger-arg-path: promotes nsubj controller:Positive_regulationt&interceding-token ngrams: vitro and extae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ask1'] Gene_or_gene_productt)interceding-token ngrams: Raf-1 catalytictIe2: trigger-arg-path: inhibited >dobj [lemma='ask1'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: mutant inhibitedt0interceding-token ngrams: activity and apoptosist?e2: trigger-arg-path: inhibited >nsubj >nn Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ask1'] controlled:Gene_or_gene_productt!interceding-token ngrams: of ASK1tJe1: trigger-arg-path: Binding >prep_to [lemma='ask1'] Gene_or_gene_productt,interceding-token ngrams: catalytic activityt#interceding-token ngrams: ASK1 as atPe1: trigger-arg-path: Binding >prep_to [lemma='ask1'] theme:Gene_or_gene_productt!interceding-token ngrams: . Raf-1tHe1: trigger-arg-path: binds >prep_to [lemma='ask1'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt(interceding-token ngrams: the control oftIe2: trigger-arg-path: inhibited:Negative_activation >nsubj >nn controllertTe2: trigger-arg-path: inhibited >dobj [lemma='ask1'] controlled:Gene_or_gene_producttNe1: trigger-arg-path: binds >prep_to [lemma='ask1'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Raf-1'] Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER 1 mutantt;e1: trigger-arg-path: Binding >prep_to [lemma='ask1'] themet?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >prep_to [lemma='ask1'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ask1'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ask1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >nsubj [lemma='Raf-1'] Gene_or_gene_productthe2: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertde2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertye2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ask1'] controlledtie2: trigger-arg-path: inhibited >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >nsubj [lemma='Raf-1'] themet$interceding-token ngrams: of ASK1 astfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Raf-1'] theme:Gene_or_gene_productt*interceding-token ngrams: was not requiredt)interceding-token ngrams: and apoptosis .tme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ask1'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Raf-1'] Gene_or_gene_producttse2: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ask1'] Gene_or_gene_productt'interceding-token ngrams: and apoptosistJe2: trigger-arg-path: inhibited >nsubj >nn controller:Gene_or_gene_producttGe1: trigger-arg-path: binds >nsubj [lemma='Raf-1'] Gene_or_gene_productt-e2: args2Role-mention-ngram: mutant inhibitedt^e2: trigger-arg-path: Negative_activation >dobj [lemma='ask1'] controlled:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Raf-1'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='Raf-1'] theme:Gene_or_gene_productt+interceding-token ngrams: apoptosis . Raf-1t8e1: trigger-arg-path: binds >nsubj [lemma='Raf-1'] themet]e2: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='ask1'] Gene_or_gene_producttTe2: trigger-arg-path: Negative_activation >nsubj >nn controller:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='Raf-1'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='Raf-1'] themetSe2: trigger-arg-path: Negative_activation >dobj [lemma='ask1'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controllertSe2: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='ask1'] controlledthe2: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='ask1'] controlled:Gene_or_gene_productt&interceding-token ngrams: activity wast}e2: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_producttDe2: trigger-arg-path: inhibited:Negative_activation >dobj controlledt%interceding-token ngrams: kinase deadt!interceding-token ngrams: controlt/interceding-token ngrams: inhibiting its kinasetre2: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt(interceding-token ngrams: inhibiting itst5e2: ents2Label-mention-ngram: mutant inhibited SHAREDtMe1: trigger-arg-path: binds >nsubj [lemma='Raf-1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt?interceding-tokens-full-span: inhibiting its kinase activity and apoptosis . Raf-1 catalytic activity was not required for the control of ASK1 as a kinase deadt9e1: trigger-arg-path: binds >prep_to [lemma='ask1'] themetIe2: trigger-arg-path: Negative_activation >dobj [lemma='ask1'] controlledtPe1: trigger-arg-path: binds:Binding >prep_to [lemma='ask1'] Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >prep_to [lemma='ask1'] theme:Gene_or_gene_productthe2: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllert^e2: trigger-arg-path: inhibited >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ask1'] controlled:Gene_or_gene_productt^e2: trigger-arg-path: inhibited:Negative_activation >nsubj >nn controller:Gene_or_gene_producttSe2: trigger-arg-path: inhibited:Negative_activation >nsubj >nn Gene_or_gene_productt5e2: trigger-arg-path: inhibited >nsubj >nn controllert&interceding-token ngrams: not requiredtOe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ask1'] controlledt'interceding-token ngrams: a kinase deadt%interceding-token ngrams: as a kinasetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ask1'] themet2interceding-token ngrams: Raf-1 catalytic activitytinterceding-token ngrams: deadt-e2: ents2Label-mention-ngram: SHARED 1 mutantt%e2: args2Role-mention-ngram: 1 mutantt%interceding-token ngrams: the controlt+interceding-token ngrams: . Raf-1 catalytict8e2: args2Role-mention-ngram: mutant inhibited CONTROLLEDt*interceding-token ngrams: activity was nott$interceding-token ngrams: control oft:e2: trigger-arg-path: inhibited >dobj Gene_or_gene_productt?e2: trigger-arg-path: Negative_activation >nsubj >nn controllertOe1: trigger-arg-path: Binding >nsubj [lemma='Raf-1'] theme:Gene_or_gene_productt)interceding-token ngrams: for the controltIe2: trigger-arg-path: Negative_activation >nsubj >nn Gene_or_gene_productt/e2: args2Role-mention-ngram: 1 mutant inhibitedt?e2: trigger-arg-path: inhibited >dobj [lemma='ask1'] controlledtNe2: trigger-arg-path: inhibited:Negative_activation >dobj Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ask1'] theme:Gene_or_gene_productt*interceding-token ngrams: not required fortinterceding-token ngrams: ASK1tYe2: trigger-arg-path: inhibited:Negative_activation >dobj controlled:Gene_or_gene_productt0interceding-token ngrams: catalytic activity wast0e2: trigger-arg-path: inhibited >dobj controlledtEe2: trigger-arg-path: inhibited >dobj controlled:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ask1'] themet!interceding-token ngrams: ASK1 astOe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Gene_or_gene_productt"interceding-token ngrams: a kinasetUe1: trigger-arg-path: binds:Binding >nsubj [lemma='Raf-1'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: 1 mutant inhibitedt^e2: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllert:e1: trigger-arg-path: Binding >nsubj [lemma='Raf-1'] themet&e2: ents2Label-mention-ngram: 1 mutanttTe2: trigger-arg-path: inhibited >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertCSSPATH: ROOT  ++ ROOT >advclt)interceding-token ngrams: control of ASK1t!e2: ents2Label-mention-ngram: Omit;e2: ents2Label-mention-ngram: and increased phosphorylationt%interceding-token ngrams: cleavage oft"e1: ents2Label-mention-ngram: downt6e2: ents2Label-mention-ngram: beta-actin and increasedt3e2: args2Role-mention-ngram: inhibitor Ucf-101 alsot.e2: args2Role-mention-ngram: and Omi inhibitort%e2: ents2Label-mention-ngram: and Omit$interceding-token ngrams: beta-actint'interceding-token ngrams: of beta-actint)e2: ents2Label-mention-ngram: cleavage oft`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='htra2'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: restored downt.e1: args2Role-mention-ngram: Omi restored downt\e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='htra2'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: Ucf-101 alsot%e2: args2Role-mention-ngram: cleavaget2e1: ents2Label-mention-ngram: induced by oncogenict5e2: ents2Label-mention-ngram: Ucf-101 also diminishedt*e1: ents2Label-mention-ngram: Omi restoredt%e1: ents2Label-mention-ngram: and Omit$e1: args2Role-mention-ngram: and Omitge2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='htra2'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: Omi inhibitor Ucf-101t*e2: args2Role-mention-ngram: and increasedt(interceding-token ngrams: and diminishedt/e2: args2Role-mention-ngram: CONTROLLER and Omit_e1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >prep_of controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: beta-actin andtqe1: trigger-arg-path: restored:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controllert5e2: args2Role-mention-ngram: and increased CONTROLLEDtNe1: trigger-arg-path: restored >nsubj >prep_of controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: beta-actin andtKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='htra2'] controllert.e1: ents2Label-mention-ngram: regulated SHAREDt*e2: args2Role-mention-ngram: Omi inhibitort)interceding-token ngrams: of beta-actin .t?e1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controllert/e2: ents2Label-mention-ngram: and Omi inhibitort/e2: ents2Label-mention-ngram: of beta-actin andt,e2: ents2Label-mention-ngram: diminished thet%e1: args2Role-mention-ngram: restoredt?e1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='htra2'] controllert4e1: args2Role-mention-ngram: restored down regulatedt+e2: args2Role-mention-ngram: diminished thet5e1: ents2Label-mention-ngram: phosphorylation inducedtse1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: oncogenic FAMILYtxe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] Gene_or_gene_productt3e2: args2Role-mention-ngram: cleavage of beta-actint&e1: ents2Label-mention-ngram: restoredt9e1: trigger-arg-path: restored >nsubj >prep_of controllert.e2: args2Role-mention-ngram: inhibitor Ucf-101t e1: args2Role-mention-ngram: Omitge1: trigger-arg-path: restored >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] Gene_or_gene_productt*e1: args2Role-mention-ngram: restored downt(e2: args2Role-mention-ngram: cleavage oft,e1: ents2Label-mention-ngram: down regulatedtne1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controllert5e2: args2Role-mention-ngram: beta-actin and increasedt&e2: ents2Label-mention-ngram: cleavagetUe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='htra2'] controllert.e1: ents2Label-mention-ngram: and Omi restoredt4e2: args2Role-mention-ngram: diminished the cleavaget+e2: ents2Label-mention-ngram: and increasedt$interceding-token ngrams: diminishedt+e2: ents2Label-mention-ngram: Omi inhibitort1interceding-token ngrams: diminished the cleavaget>e1: ents2Label-mention-ngram: regulated SHARED phosphorylationtVe2: trigger-arg-path: increased >nsubj [lemma='htra2'] controller:Gene_or_gene_producttre1: trigger-arg-path: restored >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controller:Gene_or_gene_productt e2: args2Role-mention-ngram: Omit-e2: ents2Label-mention-ngram: the cleavage oft$e2: args2Role-mention-ngram: and Omit}e1: trigger-arg-path: Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controller:Gene_or_gene_productthe1: trigger-arg-path: Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controllert(e2: ents2Label-mention-ngram: beta-actint)interceding-token ngrams: the cleavage oft/e2: ents2Label-mention-ngram: inhibitor Ucf-101tRe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='htra2'] controllert1e2: ents2Label-mention-ngram: also diminished thet1e1: args2Role-mention-ngram: regulated CONTROLLEDt*e2: ents2Label-mention-ngram: the cleavaget-e2: ents2Label-mention-ngram: also diminishedt,e2: args2Role-mention-ngram: the cleavage oft/e1: ents2Label-mention-ngram: Omi restored downt{e1: trigger-arg-path: restored:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] Gene_or_gene_productte1: trigger: restoredt4e2: ents2Label-mention-ngram: inhibitor Ucf-101 alsot)e2: args2Role-mention-ngram: Ucf-101 alsot1e1: ents2Label-mention-ngram: by oncogenic FAMILYt'e2: args2Role-mention-ngram: beta-actintCe1: trigger-arg-path: restored >nsubj >prep_of Gene_or_gene_productt*e1: ents2Label-mention-ngram: by oncogenictMinterceding-tokens-full-span: and diminished the cleavage of beta-actin . Thet&interceding-token ngrams: the cleavaget-e1: args2Role-mention-ngram: and Omi restoredt,e1: ents2Label-mention-ngram: SHARED and Omit3e2: ents2Label-mention-ngram: Omi inhibitor Ucf-101t*e2: args2Role-mention-ngram: of beta-actint?e1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controller:Gene_or_gene_productt6e1: args2Role-mention-ngram: down regulated CONTROLLEDtUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='htra2'] Gene_or_gene_producttbe1: trigger-arg-path: restored:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt&interceding-token ngrams: beta-actin .t'e1: ents2Label-mention-ngram: oncogenict8e1: ents2Label-mention-ngram: phosphorylation induced byt,e2: args2Role-mention-ngram: also diminishedt4e2: args2Role-mention-ngram: Ucf-101 also diminishedtpe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='htra2'] Gene_or_gene_productt!e1: args2Role-mention-ngram: downt/e1: args2Role-mention-ngram: CONTROLLER and OmitJe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >prep_of controllert0interceding-token ngrams: cleavage of beta-actintnsubj [lemma='htra2'] controller:Gene_or_gene_producttKe2: trigger-arg-path: increased >nsubj [lemma='htra2'] Gene_or_gene_productte1: outgoing: >prtt?e1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: Omit4e2: ents2Label-mention-ngram: cleavage of beta-actint0e2: args2Role-mention-ngram: also diminished thet(e2: ents2Label-mention-ngram: diminishedthe1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj >prep_of Gene_or_gene_producttre1: trigger-arg-path: Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: Ucf-101t^e1: trigger-arg-path: lemmatizedTrigger=restore:Negative_regulation >nsubj >prep_of controllert+e2: ents2Label-mention-ngram: of beta-actint]e1: trigger-arg-path: restored >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controllert&e1: args2Role-mention-ngram: regulatedt5e2: ents2Label-mention-ngram: diminished the cleavaget'e2: args2Role-mention-ngram: diminishedt{e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='htra2'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED and Omit.e2: args2Role-mention-ngram: of beta-actin andtAe2: trigger-arg-path: increased >nsubj [lemma='htra2'] controllertWe1: trigger-arg-path: restored:Negative_regulation >nsubj >prep_of Gene_or_gene_productt5e1: ents2Label-mention-ngram: restored down regulatedt?e1: trigger-arg-path: restored:Negative_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='htra2'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: regulatedt(interceding-token ngrams: diminished thet)e1: args2Role-mention-ngram: Omi restoredt)e2: args2Role-mention-ngram: the cleavagetTe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >prep_of Gene_or_gene_productt$e2: args2Role-mention-ngram: Ucf-101t3e1: ents2Label-mention-ngram: down regulated SHAREDt*interceding-token ngrams: beta-actin . Thet_e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='htra2'] Gene_or_gene_productt"interceding-token ngrams: cleavagetMe1: trigger-arg-path: restored:Negative_regulation >nsubj >prep_of controllert!interceding-token ngrams: is halftRe1: trigger-arg-path: interaction >prep_between [lemma='cat'] Gene_or_gene_productt?e1: trigger-arg-path: Binding >prep_between [lemma='cat'] themetAe2: trigger-arg-path: affinity >prep_between Gene_or_gene_productt:e1: trigger-arg-path: interaction >prep_between >nn Familyt:e2: trigger-arg-path: affinity:Binding >prep_between themet?interceding-tokens-full-span: . Results from these analyses indicated that the binding affinity between mUbRas and Sos cat is 8.3 + /- 0.9 muM , which is half the observed bindingtSe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between Gene_or_gene_productt$interceding-token ngrams: mUbRas andt#interceding-token ngrams: . ResultstZe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] themet5e2: trigger-arg-path: Binding >prep_between >nn themet%interceding-token ngrams: and Sos catt,interceding-token ngrams: indicated that thetWe1: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt,interceding-token ngrams: analyses indicatedt6CSSPATH: ROOT >dobj >rcmod >dobj ++ ROOT >ccomp >rcmodtDe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between themet2interceding-token ngrams: these analyses indicatedt"interceding-token ngrams: + /- 0.9tRe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] themetQe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between >nn Familyt`e2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt2e2: trigger-arg-path: affinity >prep_between themetUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] themet interceding-token ngrams: mUbRastue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt&interceding-token ngrams: the observedt&interceding-token ngrams: Results fromtinterceding-token ngrams: Sostprep_between >nn theme:Familytle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between >nn themet#interceding-token ngrams: 0.9 muM ,t+interceding-token ngrams: half the observedtinterceding-token ngrams: 0.9tUe1: trigger-arg-path: interaction >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt$interceding-token ngrams: /- 0.9 muMt?e2: trigger-arg-path: affinity:Binding >prep_between >nn FamilytLe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between >nn FamilytOe2: trigger-arg-path: affinity >prep_between [lemma='cat'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] Gene_or_gene_producttinterceding-token ngrams: muM ,tTe1: trigger-arg-path: interaction >prep_between [lemma='cat'] >nn [lemma='ra'] themet interceding-token ngrams: cat istce1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt!interceding-token ngrams: and Sost(interceding-token ngrams: . Results fromtle2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt[e2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between Gene_or_gene_productt]e2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] theme:Gene_or_gene_producttRe2: trigger-arg-path: affinity >prep_between [lemma='cat'] >nn [lemma='ra'] FamilytTe2: trigger-arg-path: Binding >prep_between [lemma='cat'] theme:Gene_or_gene_productt=e2: trigger-arg-path: affinity >prep_between >nn theme:Familyt@e2: trigger-arg-path: affinity >prep_between [lemma='cat'] themetQe1: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] FamilytPe2: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themetNe1: trigger-arg-path: Binding >prep_between [lemma='cat'] Gene_or_gene_productt interceding-token ngrams: /- 0.9t?e2: trigger-arg-path: Binding >prep_between [lemma='cat'] themetre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themetke2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themetinterceding-token ngrams: 8.3 +t!interceding-token ngrams: 0.9 muMtPe1: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themet`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] theme:Gene_or_gene_productt$interceding-token ngrams: Sos cat istOe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between >nn theme:Familytde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] Gene_or_gene_producttXe1: trigger-arg-path: interaction >prep_between [lemma='cat'] theme:Gene_or_gene_producttinterceding-token ngrams: 8.3tZe1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] Gene_or_gene_producttEe2: trigger-arg-path: affinity:Binding >prep_between >nn theme:FamilytTe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between >nn FamilytUe2: trigger-arg-path: affinity >prep_between [lemma='cat'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between >nn theme:Familyt%interceding-token ngrams: muM , whichtre2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt(interceding-token ngrams: between mUbRastWe2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] >nn [lemma='ra'] themet.e2: ents2Label-mention-ngram: affinity betweentIe2: trigger-arg-path: affinity:Binding >prep_between Gene_or_gene_productt"interceding-token ngrams: is 8.3 +tinterceding-token ngrams: cattae2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >prep_between [lemma='cat'] Gene_or_gene_producttOe2: trigger-arg-path: affinity:Binding >prep_between theme:Gene_or_gene_producttXe2: trigger-arg-path: affinity >prep_between [lemma='cat'] >nn [lemma='ra'] theme:FamilytTe1: trigger-arg-path: Binding >prep_between [lemma='cat'] theme:Gene_or_gene_producttKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] themetGe2: trigger-arg-path: affinity >prep_between theme:Gene_or_gene_productt6e1: trigger-arg-path: Binding >prep_between >nn Familyt!interceding-token ngrams: Resultst*interceding-token ngrams: affinity betweentSe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between >nn themetinterceding-token ngrams: halftWe2: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] theme:FamilytZe2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt.interceding-token ngrams: the binding affinitytinterceding-token ngrams: /-t5e2: ents2Label-mention-ngram: affinity between SHAREDt"interceding-token ngrams: 8.3 + /-t"interceding-token ngrams: half thetQe2: trigger-arg-path: affinity >prep_between [lemma='cat'] >nn [lemma='ra'] themet.interceding-token ngrams: the observed bindingtKe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between >nn themet1interceding-token ngrams: affinity between mUbRastBe1: trigger-arg-path: interaction:Binding >prep_between >nn Familyt(interceding-token ngrams: mUbRas and Sost,interceding-token ngrams: Results from theset%e2: args2Role-mention-ngram: affinitytLe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between themet interceding-token ngrams: is 8.3t6e2: trigger-arg-path: affinity >prep_between >nn themet%interceding-token ngrams: is half thetme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] >nn [lemma='ra'] theme:FamilytYe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between theme:Gene_or_gene_producttinterceding-token ngrams: +t>e2: trigger-arg-path: affinity:Binding >prep_between >nn themet[e1: trigger-arg-path: interaction >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt,interceding-token ngrams: between mUbRas andt6e2: trigger-arg-path: Binding >prep_between >nn Familyt(interceding-token ngrams: these analysestHe1: trigger-arg-path: interaction:Binding >prep_between >nn theme:Familytfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] >nn [lemma='ra'] themet1interceding-token ngrams: analyses indicated thatt\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themetje2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] >nn [lemma='ra'] theme:Familyt'interceding-token ngrams: which is halftinterceding-token ngrams: muMtge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt$interceding-token ngrams: from thesetRe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between >nn theme:FamilytAe1: trigger-arg-path: interaction:Binding >prep_between >nn themetoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] Familytie2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] Gene_or_gene_productt-interceding-token ngrams: from these analysest-e2: args2Role-mention-ngram: affinity betweentIe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between >nn Familyt2interceding-token ngrams: binding affinity betweente2: trigger: affinitytCe1: trigger-arg-path: interaction >prep_between [lemma='cat'] themetde2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt&e2: ents2Label-mention-ngram: affinitytge2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='cat'] theme:Gene_or_gene_productt9e1: trigger-arg-path: interaction >prep_between >nn themetprep_between >nn theme:Familytoe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='cat'] theme:Gene_or_gene_productt*interceding-token ngrams: observed bindingtHe2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] themet3e2: args2Role-mention-ngram: affinity between THEMEt]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] Familyt]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='cat'] themetinterceding-token ngrams: + /-tQe2: trigger-arg-path: Binding >prep_between [lemma='cat'] >nn [lemma='ra'] FamilytYe2: trigger-arg-path: affinity:Binding >prep_between [lemma='cat'] >nn [lemma='ra'] themet@e1: trigger-arg-path: interaction >prep_between >nn theme:Familyt$interceding-token ngrams: cat is 8.3tje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='cat'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between >nn theme:FamilytPe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between >nn themet*interceding-token ngrams: that the bindingt7e2: trigger-arg-path: affinity >prep_between >nn Familyt!interceding-token ngrams: Sos catt)e1: args2Role-mention-ngram: FGF elicitedt%e1: args2Role-mention-ngram: or Spry2tEe2: trigger-arg-path: Positive_activation dobj controlledtie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation dobj [lemma='activation'] >nn [lemma='erk'] controlledt-e1: ents2Label-mention-ngram: double mutant (t*e1: ents2Label-mention-ngram: Grb2 ) blockt"interceding-token ngrams: probablyt&e1: ents2Label-mention-ngram: or Spry2t!e1: args2Role-mention-ngram: P59At}e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt(e1: ents2Label-mention-ngram: Spry2 ) wtt%e1: ents2Label-mention-ngram: ) wt ort$e1: args2Role-mention-ngram: ) wt ort&interceding-token ngrams: probably duet-e1: ents2Label-mention-ngram: elicited SHAREDt%interceding-token ngrams: mutant doestme1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >dobj [lemma='phosphorylation'] controlledt"e1: args2Role-mention-ngram: blockt!interceding-token ngrams: , Spry2tre1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtSe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controllert#e1: ents2Label-mention-ngram: blockt1e1: ents2Label-mention-ngram: P304A double mutantt-e1: ents2Label-mention-ngram: mutant ( unablet)e1: ents2Label-mention-ngram: bind Grb2 )tIe1: trigger-arg-path: elicited >dobj [lemma='phosphorylation'] controlledtve2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt!interceding-token ngrams: not Rast@e2: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controller:Gene_or_gene_producttCe1: trigger-arg-path: elicited:Positive_regulation >dobj controlledt)e1: args2Role-mention-ngram: P304A doublet*e1: args2Role-mention-ngram: double mutantt#e1: ents2Label-mention-ngram: Spry2t*e1: ents2Label-mention-ngram: to bind Grb2t+e1: ents2Label-mention-ngram: block cyP andtWe1: trigger-arg-path: elicited:Positive_regulation >nsubj >prep_of Gene_or_gene_productt'e1: ents2Label-mention-ngram: bind Grb2t"e1: args2Role-mention-ngram: Spry2t!e1: args2Role-mention-ngram: ) wtt0e1: args2Role-mention-ngram: P304A double mutantt'interceding-token ngrams: Raf signalingt$interceding-token ngrams: Spry2 Y55Ftoe1: trigger-arg-path: elicited >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: block cyPt_e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt%interceding-token ngrams: not inhibittue1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controllert*e1: ents2Label-mention-ngram: FGF elicitedt=e2: trigger-arg-path: induced dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttee1: trigger-arg-path: elicited >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controller:Gene_or_gene_productt9e2: trigger-arg-path: induced dobj controlled:Phosphorylationt3e2: args2Role-mention-ngram: FGF induced CONTROLLEDt/e1: ents2Label-mention-ngram: P59A P304A doublet%e1: args2Role-mention-ngram: elicitedt(e2: args2Role-mention-ngram: FGF inducedtye1: trigger-arg-path: elicited:Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controllert,e1: ents2Label-mention-ngram: unable to bindtCe1: trigger-arg-path: elicited >nsubj >prep_of Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER ( Spry2tfe2: trigger-arg-path: induced:Positive_activation dobj [lemma='phosphorylation'] controlledtbe1: trigger-arg-path: elicited:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt&e1: ents2Label-mention-ngram: elicitedt?e1: trigger-arg-path: elicited >dobj controlled:Phosphorylationt#e1: args2Role-mention-ngram: doublet+interceding-token ngrams: Spry2 Y55F mutantt%interceding-token ngrams: signaling .t$e1: ents2Label-mention-ngram: Grb2 )t(e1: args2Role-mention-ngram: bind Grb2 )tSe1: trigger-arg-path: elicited:Positive_regulation >dobj controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt)e1: ents2Label-mention-ngram: wt or Spry2t$e1: args2Role-mention-ngram: ) blockt*e1: ents2Label-mention-ngram: P304A doublet&e1: args2Role-mention-ngram: ( Spry2 )t4e1: trigger-arg-path: elicited >dobj Phosphorylationt?interceding-tokens-full-span: but not Ras activation , probably due to an effect on Raf signaling . However , Spry2 Y55F mutant does not inhibittIe2: trigger-arg-path: Positive_activation nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: cyP andt$e1: args2Role-mention-ngram: Spry2 )t-interceding-token ngrams: signaling . Howevert$e1: args2Role-mention-ngram: cyP andtYe1: trigger-arg-path: lemmatizedTrigger=elicit >dobj [lemma='phosphorylation'] controlledt)interceding-token ngrams: mutant does nott*interceding-token ngrams: does not inhibitt.e1: ents2Label-mention-ngram: Spry2 P59A P304At,interceding-token ngrams: not Ras activationtTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: FGFt&interceding-token ngrams: an effect ontJe2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttXe2: trigger-arg-path: induced:Positive_activation nsubj >prep_of controllertce2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='activation'] >nn [lemma='erk'] controlledt(interceding-token ngrams: , probably duete1: trigger: elicitedtbe1: trigger-arg-path: elicited:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttpe1: trigger-arg-path: Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controllert"e1: args2Role-mention-ngram: wt ort"e1: ents2Label-mention-ngram: P59AtRe2: trigger-arg-path: induced dobj [lemma='phosphorylation'] Phosphorylationt&interceding-token ngrams: to an effectt#e1: ents2Label-mention-ngram: wt ortze1: trigger-arg-path: Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] Gene_or_gene_productt$interceding-token ngrams: , probablyt)e1: ents2Label-mention-ngram: cyP and FGFt%interceding-token ngrams: but not RastQe2: trigger-arg-path: induced:Positive_activation nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt$e1: args2Role-mention-ngram: and FGFtie1: trigger-arg-path: lemmatizedTrigger=elicit >dobj [lemma='phosphorylation'] controlled:PhosphorylationtXe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >dobj Phosphorylationt#e1: args2Role-mention-ngram: Grb2 )t%e1: ents2Label-mention-ngram: Spry2 )t/e2: args2Role-mention-ngram: CONTROLLER and FGFtae2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledtYe1: trigger-arg-path: elicited >dobj [lemma='phosphorylation'] controlled:Phosphorylationt1e1: ents2Label-mention-ngram: FGF elicited SHAREDt(e1: args2Role-mention-ngram: wt or Spry2t+e1: ents2Label-mention-ngram: double mutantt?e1: trigger-arg-path: lemmatizedTrigger=elicit >dobj controlledtfe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='erk'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] Gene_or_gene_producttDe1: trigger-arg-path: lemmatizedTrigger=elicit >dobj Phosphorylationt%e2: ents2Label-mention-ngram: and FGFt'e1: ents2Label-mention-ngram: ( Spry2 )t#CSSPATH: ROOT  ++ ROOT >dobj >rcmodtinterceding-token ngrams: Spry2t-e1: args2Role-mention-ngram: Spry2 P59A P304AtDe2: trigger-arg-path: induced nsubj >prep_of Gene_or_gene_productt&interceding-token ngrams: , Spry2 Y55Ft^e2: trigger-arg-path: Positive_activation dobj Phosphorylationt%e1: ents2Label-mention-ngram: to bindt"e1: ents2Label-mention-ngram: ) wttIe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj >prep_of controllertMe1: trigger-arg-path: elicited:Positive_regulation >nsubj >prep_of controllert'e1: args2Role-mention-ngram: Spry2 P59At^e1: trigger-arg-path: lemmatizedTrigger=elicit >dobj [lemma='phosphorylation'] Phosphorylationt*e1: args2Role-mention-ngram: or Spry2 P59Atze2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt%e1: args2Role-mention-ngram: ( unablet interceding-token ngrams: on Raft%e1: ents2Label-mention-ngram: and FGFt%e1: ents2Label-mention-ngram: ( Spry2t#e1: ents2Label-mention-ngram: P304At]e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj >prep_of controllertce1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >dobj controlled:Phosphorylationt$e1: args2Role-mention-ngram: ( Spry2tNe1: trigger-arg-path: elicited >nsubj >prep_of controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: ( unabletze1: trigger-arg-path: elicited >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controller:Gene_or_gene_productt*interceding-token ngrams: Y55F mutant doest?e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: Spry2 P59At^e1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj >prep_of controller:Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( Spry2t.e1: args2Role-mention-ngram: P59A P304A doublet"e1: args2Role-mention-ngram: P304At&e1: args2Role-mention-ngram: bind Grb2tme1: trigger-arg-path: elicited:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt(e1: args2Role-mention-ngram: ) block cyPt/e1: trigger-arg-path: elicited >dobj controlledt?e1: trigger-arg-path: elicited:Positive_regulation >nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] Gene_or_gene_productt0e1: args2Role-mention-ngram: elicited CONTROLLEDt;e2: trigger-arg-path: Positive_activation nsubj [lemma='overexpression'] >prep_of [lemma='sprouty2'] Gene_or_gene_productt+e1: args2Role-mention-ngram: unable to bindt&e1: args2Role-mention-ngram: block cyPt e2: args2Role-mention-ngram: FGFt%e1: args2Role-mention-ngram: mutant (t^e1: trigger-arg-path: Binding nn [lemma='tip60'] Gene_or_gene_producttKe2: trigger-arg-path: Negative_activation >nsubj [lemma='uhrf1'] controllertVe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of >nn Gene_or_gene_productt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reduced thetbe1: trigger-arg-path: complex nn [lemma='p53'] theme:Gene_or_gene_producttwe2: trigger-arg-path: reduced >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlled:Gene_or_gene_productt;e2: trigger-arg-path: reduced >dobj >prep_of >nn controlledtge1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] themet\e2: trigger-arg-path: Negative_activation >dobj >prep_of >nn controlled:Gene_or_gene_productt%interceding-token ngrams: consequencetde2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='uhrf1'] controllertve1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='uhrf1'] Gene_or_gene_producttbe1: trigger-arg-path: Binding nn [lemma='p53'] theme:Gene_or_gene_producttde2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of >nn controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: a consequencetGe2: trigger-arg-path: Negative_activation >dobj >prep_of >nn controlledtle1: trigger-arg-path: complex:Binding nn [lemma='tip60'] theme:Gene_or_gene_producttEe2: trigger-arg-path: reduced >dobj >prep_of >nn Gene_or_gene_productthe2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='uhrf1'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='uhrf1'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='uhrf1'] Gene_or_gene_producttje1: trigger-arg-path: complex:Binding nn [lemma='p53'] theme:Gene_or_gene_producttfe1: trigger-arg-path: complex:Binding nn [lemma='tip60'] Gene_or_gene_productt?e2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_producttTe2: trigger-arg-path: reduced >nsubj [lemma='uhrf1'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Binding nn [lemma='tip60'] themetie1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] themetde1: trigger-arg-path: complex nn [lemma='tip60'] theme:Gene_or_gene_producttOe1: trigger-arg-path: complex nn [lemma='tip60'] themet3e2: args2Role-mention-ngram: reduced the expressiontye2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='uhrf1'] controller:Gene_or_gene_productt(interceding-token ngrams: formation . AstUe1: trigger-arg-path: complex:Binding nn [lemma='p53'] themet?e2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of >nn controlledtne1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of >nn controlledtde1: trigger-arg-path: complex:Binding nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: reduced >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='uhrf1'] controllert3e2: args2Role-mention-ngram: CONTROLLER reduced thet?e2: trigger-arg-path: reduced >nsubj [lemma='uhrf1'] controllertae1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] themetme2: trigger-arg-path: reduced >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlledt\e1: trigger-arg-path: Binding nn [lemma='p53'] Gene_or_gene_producttinterceding-token ngrams: As atYe2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of >nn Gene_or_gene_producttSe2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='uhrf1'] controllert:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reducedtae2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of >nn controlled:Gene_or_gene_productt]e2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='uhrf1'] Gene_or_gene_productt\e1: trigger-arg-path: complex nn [lemma='p53'] Gene_or_gene_producttUe2: trigger-arg-path: Negative_activation >nsubj [lemma='uhrf1'] Gene_or_gene_producttye2: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlledtue2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of >nn controlled:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] themetWe1: trigger-arg-path: complex:Binding nn [lemma='tip60'] themet?e2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlledtPe2: trigger-arg-path: reduced >dobj >prep_of >nn controlled:Gene_or_gene_productt*interceding-token ngrams: As a consequencetprepc_in >advmod >dep >dobj >nn ++ ROOT txe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='p53'] theme:Gene_or_gene_productt)interceding-token ngrams: a consequence ,t4e2: ents2Label-mention-ngram: reduced the expressiont interceding-token ngrams: . As atje2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of >nn Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlledt`e2: trigger-arg-path: Negative_activation >nsubj [lemma='uhrf1'] controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='p53'] theme:Gene_or_gene_producttOe2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of >nn controlledtde1: trigger-arg-path: Binding nn [lemma='tip60'] theme:Gene_or_gene_productt?e2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] controlled:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='tip60'] theme:Gene_or_gene_producttMe1: trigger-arg-path: complex nn [lemma='p53'] themet^e1: trigger-arg-path: complex nn [lemma='tip60'] Gene_or_gene_productt'interceding-token ngrams: consequence ,tIe2: trigger-arg-path: reduced >nsubj [lemma='uhrf1'] Gene_or_gene_producttQe2: trigger-arg-path: Negative_activation >dobj >prep_of >nn Gene_or_gene_productt?e2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='expression'] >prep_of [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='tip60'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding nn [lemma='p53'] themet[e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of controlledtGe2: trigger-arg-path: Negative_activation >prep_of Gene_or_gene_productt@e1: trigger-arg-path: bound >nsubjpass [lemma='nf-kappab'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='nf-kappab'] themetae2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controlledtJe2: trigger-arg-path: degradation >prep_of controller:Gene_or_gene_productt)interceding-token ngrams: cytoplasm . ROStIe2: trigger-arg-path: degradation:Negative_activation >prep_of controlledt*interceding-token ngrams: , and subsequentt.e1: args2Role-mention-ngram: normally bound totBe1: trigger-arg-path: bound >prep_to [lemma='ikappa-balpha'] themet,e1: ents2Label-mention-ngram: normally boundt^e2: trigger-arg-path: degradation:Negative_activation >prep_of controller:Gene_or_gene_productt_e2: trigger-arg-path: Negative_activation >prep_of [lemma='ikappa-balpha'] Gene_or_gene_productt(e1: args2Role-mention-ngram: is normallyt0interceding-token ngrams: ROS activate NF-kappaBt,interceding-token ngrams: activate NF-kappaBtWe1: trigger-arg-path: Binding >nsubjpass [lemma='nf-kappab'] theme:Gene_or_gene_productt0interceding-token ngrams: subsequent proteasomaltje2: trigger-arg-path: Negative_activation >prep_of [lemma='ikappa-balpha'] controller:Gene_or_gene_productt?interceding-tokens-full-span: in the cytoplasm . ROS activate NF-kappaB by rapid phosphorylation , ubiquitination , and subsequent proteasomaltUe2: trigger-arg-path: Negative_activation >prep_of [lemma='ikappa-balpha'] controlledtQe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ikappa-balpha'] Gene_or_gene_producttje2: trigger-arg-path: Negative_activation >prep_of [lemma='ikappa-balpha'] controlled:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ikappa-balpha'] themet}e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ikappa-balpha'] Gene_or_gene_productt3e1: args2Role-mention-ngram: the inhibitory proteint&interceding-token ngrams: ROS activatet*interceding-token ngrams: , ubiquitinationt3e2: args2Role-mention-ngram: the inhibitory proteint*interceding-token ngrams: ubiquitination ,t+interceding-token ngrams: phosphorylation ,t.e1: args2Role-mention-ngram: THEME is normallyt5e1: args2Role-mention-ngram: inhibitory protein THEMEt/interceding-token ngrams: activate NF-kappaB bytse2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controllertSe2: trigger-arg-path: degradation:Negative_activation >prep_of Gene_or_gene_producttHe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='nf-kappab'] themetUe1: trigger-arg-path: bound >nsubjpass [lemma='nf-kappab'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: the inhibitory proteintSe1: trigger-arg-path: Binding >prep_to [lemma='ikappa-balpha'] Gene_or_gene_producttDe1: trigger-arg-path: Binding >prep_to [lemma='ikappa-balpha'] themetMe2: trigger-arg-path: degradation >prep_of [lemma='ikappa-balpha'] controlledt.interceding-token ngrams: ubiquitination , andt*interceding-token ngrams: in the cytoplasmthe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ikappa-balpha'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: inhibitory proteintJe1: trigger-arg-path: bound:Binding >prep_to [lemma='ikappa-balpha'] themetae2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controllertIe2: trigger-arg-path: degradation:Negative_activation >prep_of controllerthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='nf-kappab'] Gene_or_gene_productt)interceding-token ngrams: the cytoplasm .t(interceding-token ngrams: . ROS activatet[e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of controllert.e1: args2Role-mention-ngram: to the inhibitorytke2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] Gene_or_gene_producttbe2: trigger-arg-path: degradation >prep_of [lemma='ikappa-balpha'] controlled:Gene_or_gene_productt_e1: trigger-arg-path: bound:Binding >prep_to [lemma='ikappa-balpha'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='nf-kappab'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Negative_activation >prep_of [lemma='ikappa-balpha'] controllert1interceding-token ngrams: rapid phosphorylation ,tQe1: trigger-arg-path: Binding >nsubjpass [lemma='nf-kappab'] Gene_or_gene_productt.e1: args2Role-mention-ngram: is normally boundt?e2: trigger-arg-path: degradation >prep_of Gene_or_gene_productt,interceding-token ngrams: , ubiquitination ,t/e2: args2Role-mention-ngram: degradation of thet"interceding-token ngrams: by rapidtQe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='nf-kappab'] themetinterceding-token ngrams: rapidt+e1: args2Role-mention-ngram: normally boundtBe1: trigger-arg-path: Binding >nsubjpass [lemma='nf-kappab'] themet=e2: trigger-arg-path: Negative_activation >prep_of controlledt/e1: ents2Label-mention-ngram: normally bound tot?e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controlled:Gene_or_gene_productt%interceding-token ngrams: proteasomaltie2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='ikappa-balpha'] Gene_or_gene_productt]e1: trigger-arg-path: bound:Binding >nsubjpass [lemma='nf-kappab'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: inhibitory proteint'e2: args2Role-mention-ngram: inhibitoryt2interceding-token ngrams: by rapid phosphorylationtYe1: trigger-arg-path: bound:Binding >prep_to [lemma='ikappa-balpha'] Gene_or_gene_producttbe2: trigger-arg-path: degradation >prep_of [lemma='ikappa-balpha'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: degradation of thetGe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of controlledtMe2: trigger-arg-path: degradation >prep_of [lemma='ikappa-balpha'] controllert)e1: args2Role-mention-ngram: bound to thet:interceding-token ngrams: phosphorylation , ubiquitinationt5e2: trigger-arg-path: degradation >prep_of controlledt,e1: ents2Label-mention-ngram: protein SHAREDt.e2: args2Role-mention-ngram: of the inhibitorytEe2: ents2Label-mention-ngram: inhibitory protein GENE_OR_GENE_PRODUCTt:e2: args2Role-mention-ngram: inhibitory protein CONTROLLERt\e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of controlled:Gene_or_gene_productt(e2: ents2Label-mention-ngram: inhibitoryt_e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='ikappa-balpha'] controlledtYe1: trigger-arg-path: Binding >prep_to [lemma='ikappa-balpha'] theme:Gene_or_gene_productt4interceding-token ngrams: and subsequent proteasomaltpe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ikappa-balpha'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: normallyt,e2: ents2Label-mention-ngram: the inhibitorytOe1: trigger-arg-path: bound >nsubjpass [lemma='nf-kappab'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='nf-kappab'] theme:Gene_or_gene_producttCSSPATH: ROOT  ++ ROOT >prep_byt&interceding-token ngrams: NF-kappaB bytSe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ikappa-balpha'] themetRe2: trigger-arg-path: Negative_activation >prep_of controller:Gene_or_gene_productt/interceding-token ngrams: rapid phosphorylationt0e2: ents2Label-mention-ngram: inhibitory proteint7e1: ents2Label-mention-ngram: inhibitory protein SHAREDt/e1: ents2Label-mention-ngram: to the inhibitorytQe1: trigger-arg-path: bound >prep_to [lemma='ikappa-balpha'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: normallyt/e2: ents2Label-mention-ngram: of the inhibitoryt\e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of controller:Gene_or_gene_productt=e2: trigger-arg-path: Negative_activation >prep_of controllertRe2: trigger-arg-path: Negative_activation >prep_of controlled:Gene_or_gene_productt,interceding-token ngrams: NF-kappaB by rapidt/e1: ents2Label-mention-ngram: is normally boundtGe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of controllert*e1: ents2Label-mention-ngram: bound to thet)e1: ents2Label-mention-ngram: is normallytpe2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of controlled:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='ikappa-balpha'] controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='nf-kappab'] Gene_or_gene_producttinterceding-token ngrams: . ROSt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT is normallyt:e2: ents2Label-mention-ngram: protein GENE_OR_GENE_PRODUCTt/e2: args2Role-mention-ngram: inhibitory proteintWe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='nf-kappab'] Gene_or_gene_productt^e2: trigger-arg-path: degradation:Negative_activation >prep_of controlled:Gene_or_gene_producttve2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controller:Gene_or_gene_producttJe2: trigger-arg-path: degradation >prep_of controlled:Gene_or_gene_productt5e2: trigger-arg-path: degradation >prep_of controllert/e2: args2Role-mention-ngram: protein CONTROLLERtWe1: trigger-arg-path: bound >prep_to [lemma='ikappa-balpha'] theme:Gene_or_gene_productt%interceding-token ngrams: cytoplasm .t+e2: args2Role-mention-ngram: the inhibitoryt4e2: ents2Label-mention-ngram: the inhibitory proteintte2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='ikappa-balpha'] controlled:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='ikappa-balpha'] controllertWe2: trigger-arg-path: degradation >prep_of [lemma='ikappa-balpha'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controlledtve2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='ikappa-balpha'] controlled:Gene_or_gene_producttMe1: trigger-arg-path: complex:Binding >nn [lemma='trka'] Gene_or_gene_productt-interceding-token ngrams: bodies and promotestWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='trka'] Gene_or_gene_producttRe1: trigger-arg-path: complex:Binding >nn [lemma='ngf'] theme:Gene_or_gene_productt=e1: trigger-arg-path: complex:Binding >nn [lemma='ngf'] themetSe1: trigger-arg-path: complex:Binding >nn [lemma='trka'] theme:Gene_or_gene_producttDe1: trigger-arg-path: complex >nn [lemma='ngf'] Gene_or_gene_productt/interceding-token ngrams: and promotes neuronalt,interceding-token ngrams: sympathetic neuront.interceding-token ngrams: is then retrogradelyt%interceding-token ngrams: cell bodiest)interceding-token ngrams: neuronal growtht+interceding-token ngrams: neuronal growth .tEe1: trigger-arg-path: Binding >nn [lemma='trka'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_productt5e1: trigger-arg-path: Binding >nn [lemma='ngf'] themet,interceding-token ngrams: to the sympathetict&interceding-token ngrams: retrogradelyt5e1: trigger-arg-path: complex >nn [lemma='ngf'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ngf'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetRe2: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themet%interceding-token ngrams: sympathetict\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ngf'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ngf'] themetle2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetoe2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_producttDe1: trigger-arg-path: Binding >nn [lemma='ngf'] Gene_or_gene_productt2interceding-token ngrams: promotes neuronal growtht!interceding-token ngrams: is thent.interceding-token ngrams: growth . Importantlyt5interceding-token ngrams: retrogradely transported totse2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ngf'] theme:Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn [lemma='trka'] themet interceding-token ngrams: neuront%interceding-token ngrams: transportedt'CSSPATH: ROOT >nsubjpass ++ ROOT >nsubjtVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ngf'] Gene_or_gene_producttKe1: trigger-arg-path: complex >nn [lemma='trka'] theme:Gene_or_gene_productt1interceding-token ngrams: sympathetic neuron cellt6e1: trigger-arg-path: Binding >nn [lemma='trka'] themetKe1: trigger-arg-path: Binding >nn [lemma='trka'] theme:Gene_or_gene_producttZe2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themet+interceding-token ngrams: promotes neuronalt)interceding-token ngrams: the sympathetictae2: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttae2: trigger-arg-path: binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_productt?interceding-tokens-full-span: is then retrogradely transported to the sympathetic neuron cell bodies and promotes neuronal growth . Importantly , thetRe2: trigger-arg-path: binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] themetye2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >nn [lemma='ngf'] theme:Gene_or_gene_productt interceding-token ngrams: bodiestJe1: trigger-arg-path: complex >nn [lemma='ngf'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_productt$interceding-token ngrams: bodies andt%interceding-token ngrams: neuron cellt,interceding-token ngrams: transported to thetHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='trka'] themet0interceding-token ngrams: the sympathetic neurontEe1: trigger-arg-path: complex >nn [lemma='trka'] Gene_or_gene_productt"interceding-token ngrams: growth .t6e1: trigger-arg-path: complex >nn [lemma='trka'] themetge2: trigger-arg-path: Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_productt2interceding-token ngrams: retrogradely transportedtLe1: trigger-arg-path: complex:Binding >nn [lemma='ngf'] Gene_or_gene_productt7interceding-token ngrams: then retrogradely transportedt_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='trka'] Gene_or_gene_producttie2: trigger-arg-path: binding:Binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='trka'] theme:Gene_or_gene_productt,interceding-token ngrams: neuron cell bodiestOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ngf'] themet(interceding-token ngrams: transported tot)interceding-token ngrams: cell bodies andt+interceding-token ngrams: then retrogradelytge2: trigger-arg-path: binding >prep_of [lemma='ngf'] >prep_to [lemma='trka'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='trka'] theme:Gene_or_gene_productt"interceding-token ngrams: neuronaltPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='trka'] themet[e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='mcp110'] Gene_or_gene_productt@e2: trigger-arg-path: reduced >nsubj [lemma='mcp110'] controllertde2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='pulldown'] >prep_of [lemma='ra'] Familyt9e1: trigger-arg-path: interaction >nn [lemma='raf'] themet.interceding-token ngrams: Ras-Raf interactionstZe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] Gene_or_gene_productt%e2: args2Role-mention-ngram: pulldowntfe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt%interceding-token ngrams: analyses oftHe1: trigger-arg-path: interaction >nn [lemma='raf'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of controlledtXe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of Familyt-e2: args2Role-mention-ngram: dose-dependentlyt&interceding-token ngrams: in mammaliantLe2: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] controllertVe2: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: Raf-RBD pulldowntze2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt%interceding-token ngrams: biochemicalt3e2: args2Role-mention-ngram: pulldown of CONTROLLEDt%e2: ents2Label-mention-ngram: Raf-RBDt-e2: ents2Label-mention-ngram: reduced Raf-RBDt5e2: args2Role-mention-ngram: dose-dependently reducedtCe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dose-dependentlyt8e2: args2Role-mention-ngram: CONTROLLER dose-dependentlytae2: trigger-arg-path: Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlledtie2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='mcp110'] controller:Gene_or_gene_producttge2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] Familyt&e2: ents2Label-mention-ngram: pulldownt,interceding-token ngrams: analyses of MCP110tce2: trigger-arg-path: Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlledt3e2: trigger-arg-path: reduced >dobj >prep_of Familyt)interceding-token ngrams: interactions int,e2: args2Role-mention-ngram: reduced Raf-RBDtke2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlledt`e1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] theme:Gene_or_gene_productt$e2: args2Role-mention-ngram: Raf-RBDtbe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] Gene_or_gene_producttKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT dose-dependently reducedtQe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='mcp110'] controllert+interceding-token ngrams: . Our biochemicalt)interceding-token ngrams: Our biochemicaltOe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of controlled:FamilytUe2: trigger-arg-path: reduced >nsubj [lemma='mcp110'] controller:Gene_or_gene_productt2interceding-token ngrams: Our biochemical analysestxe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] Familyt/interceding-token ngrams: disruption of Ras-Raft?e2: trigger-arg-path: Negative_activation >dobj >prep_of Familyt=e2: args2Role-mention-ngram: dose-dependently reduced Raf-RBDt1e2: ents2Label-mention-ngram: Raf-RBD pulldown oft-interceding-token ngrams: mediated disruptiont6e2: ents2Label-mention-ngram: reduced Raf-RBD pulldowntoe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlled:Familyt)interceding-token ngrams: MCP110 mediatedt1interceding-token ngrams: biochemical analyses oft)e2: ents2Label-mention-ngram: pulldown oft,interceding-token ngrams: in mammalian cellst-e2: args2Role-mention-ngram: Raf-RBD pulldownt0interceding-token ngrams: mammalian cells showedtKe2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of controlledtinterceding-token ngrams: . Ourt!interceding-token ngrams: Ras-Raft0e2: args2Role-mention-ngram: Raf-RBD pulldown ofthe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] theme:Gene_or_gene_producttinterceding-token ngrams: Ourt>e2: trigger-arg-path: reduced >dobj >prep_of controlled:FamilytBe1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT interactiont&interceding-token ngrams: cells showedtSe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='raf'] themetGe2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of Familyt4interceding-token ngrams: MCP110 mediated disruptiont_e2: trigger-arg-path: Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] Familyt+interceding-token ngrams: cells showed thatt)interceding-token ngrams: mammalian cellstoe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: pulldown of SHAREDtHe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of controlledt.e2: ents2Label-mention-ngram: dose-dependentlyt5e2: args2Role-mention-ngram: reduced Raf-RBD pulldowntTe2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='mcp110'] controllert,interceding-token ngrams: of MCP110 mediatedt#interceding-token ngrams: mammaliantWe2: trigger-arg-path: reduced >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlledt7e2: trigger-arg-path: reduced >dobj >prep_of controlledtSe2: trigger-arg-path: reduced >dobj [lemma='pulldown'] >prep_of [lemma='ra'] Familytee2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='mcp110'] controllert0interceding-token ngrams: mediated disruption oftdobj >amod >prep_with >prep_of ++ ROOT >ccomptKe1: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='raf'] themet?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlled:FamilytNe1: trigger-arg-path: interaction >nn [lemma='raf'] theme:Gene_or_gene_productt$interceding-token ngrams: of Ras-Rafthe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlledtDe2: trigger-arg-path: lemmatizedTrigger=reduce >dobj >prep_of FamilytVe1: trigger-arg-path: interaction:Binding >nn [lemma='raf'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: pulldown oftje2: trigger-arg-path: Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlled:Familyt@e2: args2Role-mention-ngram: CONTROLLER dose-dependently reducedtRe2: trigger-arg-path: reduced:Negative_activation >dobj >prep_of controlled:Familyt?interceding-tokens-full-span: . Our biochemical analyses of MCP110 mediated disruption of Ras-Raf interactions in mammalian cells showed thattJe2: trigger-arg-path: reduced >nsubj [lemma='mcp110'] Gene_or_gene_productt1interceding-token ngrams: of Ras-Raf interactionst>e2: ents2Label-mention-ngram: dose-dependently reduced Raf-RBDtJe2: trigger-arg-path: Negative_activation >dobj >prep_of controlled:Familyt^e2: trigger-arg-path: reduced >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlled:Familyt1interceding-token ngrams: Ras-Raf interactions int>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT interactiontce2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj >prep_of controlled:Familyt^e2: trigger-arg-path: reduced:Negative_activation >nsubj [lemma='mcp110'] Gene_or_gene_productt.interceding-token ngrams: biochemical analysest6e2: ents2Label-mention-ngram: dose-dependently reducedt3interceding-token ngrams: interactions in mammaliantre2: trigger-arg-path: reduced:Negative_activation >dobj [lemma='pulldown'] >prep_of [lemma='ra'] controlled:FamilytPe1: trigger-arg-path: interaction:Binding >nn [lemma='raf'] Gene_or_gene_producttAe1: trigger-arg-path: interaction:Binding >nn [lemma='raf'] themetWe1: trigger-arg-path: disrupt:Negative_regulation conj_but >nsubjpass >prep_of >vmod ++ ROOT >dep >pcomp >ccompthe1: trigger-arg-path: disrupt:Negative_regulation nn [lemma='sp'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetbe1: trigger-arg-path: Binding >nsubj [lemma='factor'] >dep [lemma='sp'] theme:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep themet(interceding-token ngrams: and acceleratet>e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep themet[e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='sp'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] >dep [lemma='sp'] Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding >nn [lemma='egr-1'] themet*interceding-token ngrams: Whereas curcumint1interceding-token ngrams: promoter and acceleratet'interceding-token ngrams: gene promotert`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egr-1'] Gene_or_gene_productt#interceding-token ngrams: EGFR mRNAt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] >dep [lemma='sp'] themet;e1: trigger-arg-path: bind >nsubj >dep Gene_or_gene_producttle1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_productt1interceding-token ngrams: transcription . WhereastIe1: trigger-arg-path: bind:Binding >nsubj >dep theme:Gene_or_gene_productt,interceding-token ngrams: mRNA transcriptiontye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] theme:Gene_or_gene_producttae1: trigger-arg-path: bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nn [lemma='sp'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep theme:Gene_or_gene_productt$interceding-token ngrams: acceleratetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] themetKe2: trigger-arg-path: binding:Binding >nn [lemma='sp'] Gene_or_gene_productt4e2: trigger-arg-path: Binding >nn [lemma='sp'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='factor'] >dep [lemma='sp'] themet#interceding-token ngrams: . WhereastNe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='sp'] themetinterceding-token ngrams: mRNAtve1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_productt4e2: trigger-arg-path: binding >nn [lemma='sp'] themet7e2: trigger-arg-path: Binding >nn [lemma='egr-1'] themetJe1: trigger-arg-path: bind:Binding >prep_to >nn theme:Gene_or_gene_producttae1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egr-1'] Gene_or_gene_productt-e1: trigger-arg-path: bind >prep_to >nn themetge1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_producttQe2: trigger-arg-path: binding:Binding >nn [lemma='sp'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='factor'] >dep [lemma='sp'] theme:Gene_or_gene_productt.interceding-token ngrams: accelerate EGFR mRNAtfe1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_producttWe1: trigger-arg-path: bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] themet)interceding-token ngrams: accelerate EGFRtce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='sp'] theme:Gene_or_gene_productt^e1: trigger-arg-path: bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt4e1: trigger-arg-path: bind:Binding >nsubj >dep themetNe2: trigger-arg-path: binding:Binding >nn [lemma='egr-1'] Gene_or_gene_productt5interceding-token ngrams: Whereas curcumin attenuatestJe1: trigger-arg-path: bind >nsubj [lemma='factor'] >dep [lemma='sp'] themetAe1: trigger-arg-path: bind >nsubj >dep theme:Gene_or_gene_producttCe2: trigger-arg-path: Binding >nn [lemma='sp'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='egr-1'] theme:Gene_or_gene_productt>e1: trigger-arg-path: Binding >nsubj >dep Gene_or_gene_productt$interceding-token ngrams: attenuatestprep_to >nn Gene_or_gene_producttpinterceding-tokens-full-span: gene promoter and accelerate EGFR mRNA transcription . Whereas curcumin attenuatestUe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='sp'] Gene_or_gene_producttCe2: trigger-arg-path: binding >nn [lemma='sp'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: bind to GENE_OR_GENE_PRODUCTt'e1: args2Role-mention-ngram: THEME bindtTe2: trigger-arg-path: binding:Binding >nn [lemma='egr-1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >dep theme:Gene_or_gene_productt1interceding-token ngrams: EGFR mRNA transcriptiont+interceding-token ngrams: gene promoter andtBe1: trigger-arg-path: bind >prep_to >nn theme:Gene_or_gene_producttde1: trigger-arg-path: bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] Gene_or_gene_producttOe1: trigger-arg-path: bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] themet,interceding-token ngrams: . Whereas curcumintCe1: trigger-arg-path: bind:Binding >nsubj >dep Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetFe2: trigger-arg-path: binding >nn [lemma='egr-1'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egr-1'] themet\e1: trigger-arg-path: Binding >nsubj [lemma='factor'] >dep [lemma='sp'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='egr-1'] Gene_or_gene_producttDe1: trigger-arg-path: Binding >nsubj >dep theme:Gene_or_gene_producttLe2: trigger-arg-path: binding >nn [lemma='egr-1'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bind:Binding >prep_to >nn Gene_or_gene_productt-interceding-token ngrams: curcumin attenuatest7e2: trigger-arg-path: binding >nn [lemma='egr-1'] themet-interceding-token ngrams: and accelerate EGFRtRe1: trigger-arg-path: Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] themetFe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='sp'] themet!interceding-token ngrams: WhereastQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egr-1'] themetYe1: trigger-arg-path: bind >nsubj [lemma='factor'] >dep [lemma='sp'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: SHARED bindt5e1: trigger-arg-path: bind:Binding >prep_to >nn themetxe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED bind totnn [lemma='sp'] themet_e1: trigger-arg-path: bind >nsubj [lemma='factor'] >dep [lemma='sp'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egr-1'] theme:Gene_or_gene_producttRe1: trigger-arg-path: bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] themet,e1: trigger-arg-path: bind >nsubj >dep themet]e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='sp'] Gene_or_gene_productt.interceding-token ngrams: mRNA transcription .t/e1: trigger-arg-path: Binding >nsubj >dep themetge1: trigger-arg-path: bind:Binding >nsubj [lemma='factor'] >dep [lemma='sp'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >dep Gene_or_gene_productt"interceding-token ngrams: curcumint~e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] >nn [lemma='egfr'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME bind totfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egr-1'] theme:Gene_or_gene_productt-interceding-token ngrams: positive regulatorst[e1: trigger-arg-path: elicit:Positive_regulation nn controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: which enhance thet;e1: ents2Label-mention-ngram: intrinsic Ras-GTPase activitytme1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn controller:Gene_or_gene_productte1: trigger: elicitt2interceding-token ngrams: regulators correspond tot)interceding-token ngrams: Ras-GEFs ) thattUe1: trigger-arg-path: elicit nn [lemma='gtpase'] controllert&interceding-token ngrams: ( Ras-GEFs )t4e1: args2Role-mention-ngram: Ras-GTPase activity andt interceding-token ngrams: so thet+interceding-token ngrams: stimulate releaset1e1: args2Role-mention-ngram: intrinsic Ras-GTPasetnn Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( Ras-GAPst?e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn [lemma='gtpase'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn controllert?interceding-tokens-full-span: . The positive regulators correspond to the guanine nucleotide exchange factors ( Ras-GEFs ) that stimulate release of bound GDP in exchange for GTP , so the activet,interceding-token ngrams: factors ( Ras-GEFstRe2: trigger-arg-path: complex:Binding >nn [lemma='gtp'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=elicit nn [lemma='gtpase'] Gene_or_gene_productt$interceding-token ngrams: ( Ras-GEFst,e1: args2Role-mention-ngram: , which enhancet~e1: trigger-arg-path: elicit:Positive_regulation nn [lemma='gtpase'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: the intrinsictYe1: trigger-arg-path: lemmatizedTrigger=elicit nn controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: elicit rapidt)e1: args2Role-mention-ngram: Ras-GAPs ) ,t%interceding-token ngrams: the guaninet1e1: ents2Label-mention-ngram: hydrolysis of boundt'e1: args2Role-mention-ngram: Ras-GTPaset)interceding-token ngrams: GDP in exchanget4e1: args2Role-mention-ngram: elicit rapid CONTROLLEDt$interceding-token ngrams: correspondt(e1: ents2Label-mention-ngram: Ras-GTPaset&interceding-token ngrams: of bound GDPtwe1: trigger-arg-path: Positive_regulation nn [lemma='gtpase'] controller:Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='gtp'] themet2e1: args2Role-mention-ngram: enhance the intrinsict&e1: args2Role-mention-ngram: intrinsict6e1: ents2Label-mention-ngram: the intrinsic Ras-GTPasetje1: trigger-arg-path: elicit nn [lemma='gtpase'] controller:Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='gtp'] Gene_or_gene_productt/interceding-token ngrams: regulators correspondt2e1: args2Role-mention-ngram: CONTROLLER ( Ras-GAPst0interceding-token ngrams: that stimulate releaset#interceding-token ngrams: stimulatet$e1: ents2Label-mention-ngram: elicitt-e1: args2Role-mention-ngram: rapid CONTROLLEDt$interceding-token ngrams: regulatorstOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] themet3e1: ents2Label-mention-ngram: enhance the intrinsict'e1: ents2Label-mention-ngram: intrinsictDe1: trigger-arg-path: lemmatizedTrigger=elicit nn controllert1interceding-token ngrams: The positive regulatorst*e1: args2Role-mention-ngram: which enhancet&interceding-token ngrams: The positivet'interceding-token ngrams: so the activet?e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn [lemma='gtpase'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: which enhance thet(interceding-token ngrams: to the guaninet&e1: ents2Label-mention-ngram: of boundtse1: trigger-arg-path: elicit:Positive_regulation nn [lemma='gtpase'] Gene_or_gene_productt'interceding-token ngrams: correspond totinterceding-token ngrams: , sot*e1: ents2Label-mention-ngram: elicit rapidt interceding-token ngrams: GDP intDe2: trigger-arg-path: Binding >nn [lemma='gtp'] Gene_or_gene_producttbe1: trigger-arg-path: Positive_regulation nn [lemma='gtpase'] controllert%interceding-token ngrams: in exchanget&interceding-token ngrams: exchange fort"interceding-token ngrams: positivetVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] Gene_or_gene_productt(interceding-token ngrams: . The positivet-e1: ents2Label-mention-ngram: , which enhancet'e1: args2Role-mention-ngram: Ras-GAPs )t5e2: trigger-arg-path: Binding >nn [lemma='gtp'] themet5interceding-token ngrams: nucleotide exchange factorstPe1: trigger-arg-path: elicit:Positive_regulation nn Gene_or_gene_productt#e1: args2Role-mention-ngram: elicitt5e2: trigger-arg-path: complex >nn [lemma='gtp'] themet5e1: args2Role-mention-ngram: the intrinsic Ras-GTPaset.e1: ents2Label-mention-ngram: and elicit rapidt4CSSPATH: ROOT >dobj >rcmod ++ ROOT >parataxis >nsubjt+interceding-token ngrams: correspond to thet:e1: args2Role-mention-ngram: intrinsic Ras-GTPase activityt(e1: ents2Label-mention-ngram: Ras-GAPs )t"interceding-token ngrams: GTP , sot*e1: ents2Label-mention-ngram: Ras-GAPs ) ,t8interceding-token ngrams: positive regulators correspondt)e1: args2Role-mention-ngram: ( Ras-GAPs )t,interceding-token ngrams: exchange factors (t1e1: ents2Label-mention-ngram: activity and elicitt)interceding-token ngrams: in exchange fort*interceding-token ngrams: exchange factorstLe2: trigger-arg-path: complex:Binding >nn [lemma='gtp'] Gene_or_gene_productt"interceding-token ngrams: , so thet_e1: trigger-arg-path: elicit nn [lemma='gtpase'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: intrinsic Ras-GTPaset0interceding-token ngrams: the guanine nucleotidet(e1: ents2Label-mention-ngram: and elicitt1e1: ents2Label-mention-ngram: Ras-GTPase activityt*interceding-token ngrams: ) that stimulatetGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] themetde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: ( Ras-GAPstie1: trigger-arg-path: elicit:Positive_regulation nn [lemma='gtpase'] controllert5e1: ents2Label-mention-ngram: Ras-GTPase activity andt$interceding-token ngrams: Ras-GEFs )tge1: trigger-arg-path: lemmatizedTrigger=elicit nn [lemma='gtpase'] controllert|e1: trigger-arg-path: lemmatizedTrigger=elicit nn [lemma='gtpase'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: ( Ras-GAPst'e1: args2Role-mention-ngram: and elicitt*interceding-token ngrams: release of boundt"interceding-token ngrams: Ras-GEFst^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] Gene_or_gene_producttGe1: trigger-arg-path: elicit nn controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn [lemma='gtpase'] controllert-e1: args2Role-mention-ngram: and elicit rapidt5e1: ents2Label-mention-ngram: elicit rapid hydrolysist0e1: args2Role-mention-ngram: Ras-GTPase activityt%e1: args2Role-mention-ngram: Ras-GAPst\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] theme:Gene_or_gene_productt(interceding-token ngrams: that stimulatet-e1: ents2Label-mention-ngram: of bound SHAREDt1e1: ents2Label-mention-ngram: rapid hydrolysis oft*e1: ents2Label-mention-ngram: ( Ras-GAPs )tle1: trigger-arg-path: Positive_regulation nn [lemma='gtpase'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=elicit nn Gene_or_gene_producttFe1: trigger-arg-path: elicit:Positive_regulation nn controllert&interceding-token ngrams: bound GDP intJe2: trigger-arg-path: complex >nn [lemma='gtp'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: rapid hydrolysist*interceding-token ngrams: exchange for GTPtinterceding-token ngrams: GTP ,t+e1: ents2Label-mention-ngram: the intrinsict"interceding-token ngrams: of boundt0e1: args2Role-mention-ngram: activity and elicitt2e1: trigger-arg-path: elicit nn controllert#interceding-token ngrams: for GTP ,t.interceding-token ngrams: stimulate release oft#interceding-token ngrams: factors (tbe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_regulation nn Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='gtp'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: which enhancet&e1: ents2Label-mention-ngram: Ras-GAPstJe1: trigger-arg-path: Binding >prep_to [lemma='cdk1'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] themetJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] themetwe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: A binds totae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk1'] Gene_or_gene_producttfe2: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: A binds totie2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_productt9e1: trigger-arg-path: binds >prep_to [lemma='cdk1'] themetshortest-path: prep_to [lemma='cdk1'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: A bindst`e2: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] themetYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] Gene_or_gene_productt$e2: args2Role-mention-ngram: THEME AtYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: A binds totJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] themet%e1: ents2Label-mention-ngram: A bindst$e1: args2Role-mention-ngram: A bindstge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: binds >prep_to [lemma='cdk1'] themet$e2: args2Role-mention-ngram: A bindstQe2: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themet`e1: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt4e2: trigger-arg-path: binds:Binding >nsubj >nn themet'e1: args2Role-mention-ngram: A binds totRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk1'] themetIe1: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] themetNe1: trigger-arg-path: binds >prep_to [lemma='cdk1'] theme:Gene_or_gene_producttfe1: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binds:Binding >nsubj >nn theme:Gene_or_gene_producttPe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_to [lemma='cdk1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themete1: args2Role-mention-ngram: At;e2: trigger-arg-path: Binding >prep_to [lemma='cdk1'] themetXe1: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttZe2: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='cdk1'] theme:Gene_or_gene_producttAe2: trigger-arg-path: binds >nsubj >nn theme:Gene_or_gene_productt;e2: trigger-arg-path: binds >nsubj >nn Gene_or_gene_producttHe2: trigger-arg-path: binds >prep_to [lemma='cdk1'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED A bindst`e1: trigger-arg-path: binds:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttKe1: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themetNe2: trigger-arg-path: binds >prep_to [lemma='cdk1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt,e2: trigger-arg-path: binds >nsubj >nn themetAe1: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='cdk1'] themetoe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt`e2: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED A bindstbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themetoe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themetqe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttCe2: trigger-arg-path: binds:Binding >nsubj >nn Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk1'] themetie1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttZe1: trigger-arg-path: Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] themetAe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk1'] themetHe1: trigger-arg-path: binds >prep_to [lemma='cdk1'] Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME A bindstJe2: trigger-arg-path: Binding >prep_to [lemma='cdk1'] Gene_or_gene_productt$e1: args2Role-mention-ngram: THEME Atqe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME A bindst&e2: ents2Label-mention-ngram: SHARED At^e1: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binds >nsubj [lemma='a'] >nn [lemma='cyclin'] themet&e1: ents2Label-mention-ngram: SHARED Atae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='gtp'] themetFe2: trigger-arg-path: Binding >nn [lemma='itsn1'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='gtp'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >dobj [lemma='gtp'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex >nn [lemma='itsn1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] Gene_or_gene_productt=e1: trigger-arg-path: binds:Binding >dobj [lemma='gtp'] themet3shortest-path: prep_in >vmod >prep_from >nntLe1: trigger-arg-path: Binding >dobj [lemma='gtp'] theme:Gene_or_gene_producttJe1: trigger-arg-path: binds >dobj [lemma='gtp'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] theme:Gene_or_gene_productt?e1: ents2Label-mention-ngram: FAMILY binds GENE_OR_GENE_PRODUCTtLe2: trigger-arg-path: Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='gtp'] theme:Gene_or_gene_productt?trigger-to-trigger-path: e1:binds:Binding >prep_in [lemma='addition'] >vmod [lemma='release'] >prep_from [lemma='complex'] e2:complex:BindingtIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] themetXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] Gene_or_gene_productt?shortest-path: prep_in [lemma='addition'] >vmod [lemma='release'] >prep_from [lemma='complex'] >nn [lemma='itsn1']t7e2: trigger-arg-path: Binding >nn [lemma='itsn1'] themetFe2: trigger-arg-path: complex >nn [lemma='itsn1'] Gene_or_gene_productt7e1: trigger-arg-path: Binding >dobj [lemma='gtp'] themet5e1: trigger-arg-path: binds >dobj [lemma='gtp'] themetQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] themetFe1: trigger-arg-path: Binding >dobj [lemma='gtp'] Gene_or_gene_producttTe2: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_productt7e2: trigger-arg-path: complex >nn [lemma='itsn1'] themetLe1: trigger-arg-path: binds:Binding >dobj [lemma='gtp'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='gtp'] Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] themetUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='gtp'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='gtp'] themetDe1: trigger-arg-path: binds >dobj [lemma='gtp'] Gene_or_gene_producttVtrigger-to-trigger-path: e1:binds:Binding >prep_in >vmod >prep_from e2:complex:Bindingt#e2: ents2Label-mention-ngram: and 9t%e2: args2Role-mention-ngram: Set7 andt2e2: ents2Label-mention-ngram: disrupts the bindingt?interceding-tokens-full-span: , Lys236 , and Lys238 of the N-terminal extension . Although it is unclear whether methylation affects directly SIRT1 deacetylase activity , thetye2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='interaction'] controller:Generic_eventtDe2: trigger-arg-path: disrupts:Negative_regulation >nsubj controllert(e2: ents2Label-mention-ngram: and 9 withtOe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj controller:Generic_eventt'e2: args2Role-mention-ngram: and 9 witht*e2: ents2Label-mention-ngram: disrupts thet(e2: ents2Label-mention-ngram: Set7 and 9te2: trigger: disruptst]e2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='interaction'] Generic_eventtFe2: trigger-arg-path: disrupts >nsubj [lemma='interaction'] controllert$e2: ents2Label-mention-ngram: 9 witht'e2: args2Role-mention-ngram: Set7 and 9t&e2: ents2Label-mention-ngram: Set7 andt,e2: ents2Label-mention-ngram: SIRT1 disruptst1e2: ents2Label-mention-ngram: interaction of Set7tTe2: trigger-arg-path: Negative_regulation >nsubj [lemma='interaction'] Generic_eventt)e2: ents2Label-mention-ngram: of Set7 andtTe2: trigger-arg-path: disrupts >nsubj [lemma='interaction'] controller:Generic_eventt+e2: args2Role-mention-ngram: SIRT1 disruptstQe2: trigger-arg-path: Negative_regulation >nsubj [lemma='interaction'] controllert%e2: ents2Label-mention-ngram: of Set7t4e2: args2Role-mention-ngram: disrupts the CONTROLLEDt0e2: args2Role-mention-ngram: with SIRT1 disruptstne2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='interaction'] Generic_eventtIe2: trigger-arg-path: disrupts >nsubj [lemma='interaction'] Generic_eventt'e2: args2Role-mention-ngram: with SIRT1t!e2: args2Role-mention-ngram: Set7tZe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='interaction'] Generic_eventt/e2: args2Role-mention-ngram: CONTROLLER of Set7tAe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj controllertke2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='interaction'] controllert#e2: args2Role-mention-ngram: 9 witht(e2: args2Role-mention-ngram: of Set7 andtRe2: trigger-arg-path: disrupts:Negative_regulation >nsubj controller:Generic_eventtDe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj Generic_eventtUe2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj controllert(e2: ents2Label-mention-ngram: with SIRT1t*e2: ents2Label-mention-ngram: 9 with SIRT1t>e2: trigger-arg-path: disrupts >nsubj controller:Generic_eventt)e2: args2Role-mention-ngram: disrupts thethe2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='interaction'] controller:Generic_eventtGe2: trigger-arg-path: disrupts:Negative_regulation >nsubj Generic_eventt$e2: args2Role-mention-ngram: of Set7tce2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj controller:Generic_eventt_e2: trigger-arg-path: Negative_regulation >nsubj [lemma='interaction'] controller:Generic_eventt0e2: ents2Label-mention-ngram: SIRT1 disrupts thet0e2: trigger-arg-path: disrupts >nsubj controllertee2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='interaction'] controller:Generic_eventtZe2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='interaction'] controllert/e2: args2Role-mention-ngram: SIRT1 disrupts thet>e2: trigger-arg-path: Negative_regulation >nsubj Generic_eventtXe2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj Generic_eventt%e2: args2Role-mention-ngram: disruptst"e2: ents2Label-mention-ngram: Set7t)e2: args2Role-mention-ngram: 9 with SIRT1tIe2: trigger-arg-path: Negative_regulation >nsubj controller:Generic_eventt3e2: trigger-arg-path: disrupts >nsubj Generic_eventt&e2: ents2Label-mention-ngram: disruptst1e2: ents2Label-mention-ngram: with SIRT1 disruptst"e2: args2Role-mention-ngram: and 9tWe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='interaction'] controllert/e1: args2Role-mention-ngram: activates RalA andt\e2: trigger-arg-path: lemmatizedTrigger=induce >csubj >prep_at >prep_in Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED activatestxe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlled:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj >prep_at >prep_in controller:Gene_or_gene_productt.interceding-token ngrams: RalA phosphorylationt1interceding-token ngrams: cellular transformationt?e2: trigger-arg-path: Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controllertinterceding-token ngrams: RalAt&interceding-token ngrams: role of RalAtje2: trigger-arg-path: induced:Positive_activation >csubj >prep_at >prep_in controller:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='aurora-a'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: RalAt interceding-token ngrams: ser194t?e2: trigger-arg-path: induced >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj >prep_at >prep_in controllert?interceding-tokens-full-span: at serine194 to promote cellular transformation and migration . To reveal the role of RalA phosphorylation at ser194 int?e2: trigger-arg-path: Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controller:Gene_or_gene_producttke2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlledtUe2: trigger-arg-path: induced:Positive_activation >csubj >prep_at >prep_in controllert0e1: ents2Label-mention-ngram: activates RalA andtce1: trigger-arg-path: Positive_regulation >nsubj [lemma='aurora-a'] controller:Gene_or_gene_producttVe2: trigger-arg-path: induced >csubj >prep_at >prep_in controller:Gene_or_gene_productt?e2: trigger-arg-path: induced:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controller:Gene_or_gene_productt3interceding-token ngrams: phosphorylation at ser194t#interceding-token ngrams: To revealt?e2: trigger-arg-path: induced >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED activates RalAt]e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='aurora-a'] controllert!interceding-token ngrams: of RalAt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] Gene_or_gene_producttIe1: trigger-arg-path: phosphorylates >nsubj [lemma='aurora-a'] controllert,e1: ents2Label-mention-ngram: activates RalAtAe2: trigger-arg-path: induced >csubj >prep_at >prep_in controllertle2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ralum'] controlled:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ralum'] controlledt%interceding-token ngrams: the role oft)interceding-token ngrams: at serine194 totXe1: trigger-arg-path: Positive_regulation >nsubj [lemma='aurora-a'] Gene_or_gene_productt(interceding-token ngrams: migration . Tot#interceding-token ngrams: migrationt^e1: trigger-arg-path: phosphorylates >nsubj [lemma='aurora-a'] controller:Gene_or_gene_productt"interceding-token ngrams: the rolet&interceding-token ngrams: at ser194 int?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controller:Gene_or_gene_productt?e2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlled:Gene_or_gene_producttve2: trigger-arg-path: induced >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controllert5e1: ents2Label-mention-ngram: RalA and phosphorylatest?e2: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controller:Gene_or_gene_productt%interceding-token ngrams: . To revealt1interceding-token ngrams: RalA phosphorylation att0e1: args2Role-mention-ngram: RalA and CONTROLLEDt#interceding-token ngrams: serine194tZe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='aurora-a'] controllert9interceding-token ngrams: promote cellular transformationt!e1: args2Role-mention-ngram: RalAt?e2: trigger-arg-path: induced:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controllert}e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ralum'] controlled:Gene_or_gene_productt6interceding-token ngrams: transformation and migrationtre1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='aurora-a'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] Gene_or_gene_productt_e2: trigger-arg-path: induced:Positive_activation >csubj >prep_at >prep_in Gene_or_gene_producttWe2: trigger-arg-path: Positive_activation >csubj >prep_at >prep_in Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controllert#interceding-token ngrams: at ser194tpe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj >prep_at >prep_in Gene_or_gene_productt?e2: trigger-arg-path: induced:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] Gene_or_gene_producttWe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ralum'] controlledtue2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] Gene_or_gene_productt)interceding-token ngrams: reveal the roletoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='aurora-a'] controller:Gene_or_gene_productt$interceding-token ngrams: reveal thetge1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='aurora-a'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >csubj >prep_at >prep_in controller:Gene_or_gene_productt-interceding-token ngrams: to promote cellulart)interceding-token ngrams: and migration .t?e2: trigger-arg-path: lemmatizedTrigger=induce >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] controllert,interceding-token ngrams: phosphorylation att&interceding-token ngrams: serine194 totSe1: trigger-arg-path: phosphorylates >nsubj [lemma='aurora-a'] Gene_or_gene_productt+e1: args2Role-mention-ngram: activates RalAt#interceding-token ngrams: ser194 int?e2: trigger-arg-path: Positive_activation >csubj [lemma='reveal'] >prep_at [lemma='ser194'] >prep_in [lemma='aurora-a'] Gene_or_gene_productt.interceding-token ngrams: serine194 to promotetne1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='aurora-a'] controllertce2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlledtKe2: trigger-arg-path: induced >csubj >prep_at >prep_in Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='aurora-a'] controllert5interceding-token ngrams: cellular transformation andt6e1: args2Role-mention-ngram: CONTROLLER activates RalAt1interceding-token ngrams: of RalA phosphorylationt*interceding-token ngrams: promote cellulart?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlled:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce >csubj >prep_at >prep_in controller:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] controlledt&interceding-token ngrams: at serine194tre2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='ralum'] Gene_or_gene_productt'interceding-token ngrams: To reveal thet%e1: args2Role-mention-ngram: RalA andt'interceding-token ngrams: and migrationtde1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='aurora-a'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: RalA andt%interceding-token ngrams: migration .tRe2: trigger-arg-path: lemmatizedTrigger=induce >csubj >prep_at >prep_in controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='aurora-a'] controller:Gene_or_gene_producttme2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='ralum'] Gene_or_gene_producttae2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='ralum'] Gene_or_gene_producttMe2: trigger-arg-path: Positive_activation >csubj >prep_at >prep_in controllert interceding-token ngrams: revealt-e1: args2Role-mention-ngram: also can inhibittVe1: trigger-arg-path: inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] controlledthe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] controlledtRe1: trigger-arg-path: inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertje1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlledt}e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] controlled:Gene_or_gene_producttle1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] Gene_or_gene_producttwe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt`e1: trigger-arg-path: inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllert)e1: args2Role-mention-ngram: mutants alsot/e1: args2Role-mention-ngram: CONTROLLER mutantst-e1: args2Role-mention-ngram: mutants also cant-interceding-token ngrams: while Raf-1 bindingt\e1: trigger-arg-path: inhibit:Negative_activation >nsubj >nn controller:Gene_or_gene_producttHe1: trigger-arg-path: inhibit >nsubj >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] Gene_or_gene_productt3e1: args2Role-mention-ngram: can inhibit CONTROLLEDtre1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] Gene_or_gene_productt^e1: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertbe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controllert'interceding-token ngrams: Raf-1 bindingt,e1: ents2Label-mention-ngram: inhibit SHAREDt'interceding-token ngrams: , while Raf-1t*e1: ents2Label-mention-ngram: mutants alsotce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn Gene_or_gene_productt!interceding-token ngrams: MST2 istpe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt3e1: trigger-arg-path: inhibit >nsubj >nn controllert?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mutants alsotde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controllertge1: trigger-arg-path: inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_producttke1: trigger-arg-path: inhibit >dobj [lemma='activation'] >nn [lemma='mst2'] controlled:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt*interceding-token ngrams: Raf-1 binding tot)interceding-token ngrams: binding to MST2tfe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controllert)interceding-token ngrams: MST2 is inducedt$e1: args2Role-mention-ngram: mutantst?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt$interceding-token ngrams: binding tot=e1: trigger-arg-path: inhibit >nsubj >nn Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlled:Gene_or_gene_productte1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlled:Gene_or_gene_productt$interceding-token ngrams: to MST2 istte1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] Gene_or_gene_producttse1: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='mst2'] controlledt.e1: ents2Label-mention-ngram: also can inhibitthe1: trigger-arg-path: Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt{e1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: can inhibit SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_productt.interceding-token ngrams: activation . Howevertinterceding-tokens-full-span: activation . However , while Raf-1 binding to MST2 is induced by stress and reduced by mitogens ,t.e1: ents2Label-mention-ngram: mutants also cantne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controller:Gene_or_gene_producttQe1: trigger-arg-path: inhibit:Negative_activation >nsubj >nn Gene_or_gene_productt)interceding-token ngrams: However , whilet\e1: trigger-arg-path: inhibit >nsubj [lemma='mutant'] >nn [lemma='raf'] Gene_or_gene_producttGe1: trigger-arg-path: inhibit:Negative_activation >nsubj >nn controllert4e1: args2Role-mention-ngram: CONTROLLER mutants alsot%interceding-token ngrams: while Raf-1tde2: trigger-arg-path: Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] sitetconj_and >dobj >nn sitetGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='cdk2'] themete1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='p21'] controlled:Gene_or_gene_productt,e2: args2Role-mention-ngram: THEME binds andt+e2: ents2Label-mention-ngram: and causes G2t0e2: ents2Label-mention-ngram: inactivates Cyclint9e2: trigger-arg-path: binds >conj_and >dobj >nn site:Sitet#e2: args2Role-mention-ngram: Cyclintinterceding-token ngrams: a CDKtfe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj >nn Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj >nn controller:Gene_or_gene_producttne1: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='p21'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: upregulates >nsubj [lemma='reactivation'] >nn [lemma='p53'] controllertoe2: trigger-arg-path: binds:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] site:Sitet`e1: trigger-arg-path: upregulates:Positive_activation >nsubj >nn controller:Gene_or_gene_productt4e2: trigger-arg-path: binds >conj_and >dobj >nn sitet/e2: args2Role-mention-ngram: inactivates Cyclint:e2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT andtOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='cdk2'] themet.e2: ents2Label-mention-ngram: SHARED binds andt\e1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: upregulates SHAREDtMe2: trigger-arg-path: binds:Binding >dobj [lemma='cdk2'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] sitet@e1: trigger-arg-path: upregulates >dobj >nn Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubj [lemma='p21'] theme:Gene_or_gene_productt)interceding-token ngrams: CDK inhibitor .te2: ents2Label-mention-ngram: BtSe2: trigger-arg-path: binds:Binding >dobj [lemma='cdk2'] theme:Gene_or_gene_producttfe1: trigger-arg-path: upregulates >nsubj [lemma='reactivation'] >nn [lemma='p53'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj >nn Sitetke1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] Gene_or_gene_productt&interceding-token ngrams: expression ,tEe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj >nn sitet-e2: ents2Label-mention-ngram: and inactivatestEe2: trigger-arg-path: binds >dobj [lemma='cdk2'] Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='p21'] Gene_or_gene_producttconj_and >dobj >nn Sitet,e2: args2Role-mention-ngram: and causes SITEtne1: trigger-arg-path: Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] Gene_or_gene_productt3e2: args2Role-mention-ngram: and inactivates Cyclint)e1: args2Role-mention-ngram: reactivationt(interceding-token ngrams: expression , at4e1: args2Role-mention-ngram: CONTROLLER reactivationtde2: trigger-arg-path: Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] Sitet;e2: trigger-arg-path: Binding >conj_and >dobj >nn site:Sitet>e2: trigger-arg-path: binds:Binding >nsubj [lemma='p21'] themetae1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlledtce1: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='p21'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj >nn controllertbe2: trigger-arg-path: binds >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] sitet=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and causest\e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj >nn controllertYe1: trigger-arg-path: upregulates >dobj [lemma='expression'] >nn [lemma='p21'] controlledtje2: trigger-arg-path: binds:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] sitet4e2: trigger-arg-path: binds >conj_and >dobj >nn SitetOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p21'] themet%e2: args2Role-mention-ngram: Cyclin Bt*e2: args2Role-mention-ngram: and THEME andtge2: trigger-arg-path: binds >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] site:Sitet1e2: args2Role-mention-ngram: inactivates Cyclin BtLe1: trigger-arg-path: upregulates >nsubj >nn controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj >nn controller:Gene_or_gene_producttGe2: trigger-arg-path: Binding >dobj [lemma='cdk2'] Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='p21'] themet6e2: trigger-arg-path: binds >dobj [lemma='cdk2'] themetEe2: trigger-arg-path: binds >nsubj [lemma='p21'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] sitet,e2: args2Role-mention-ngram: and inactivatestse2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] Sitet*e2: ents2Label-mention-ngram: Cyclin B andt?e1: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controller:Gene_or_gene_producttconj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] site:SitetEe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj >nn Sitet2e2: args2Role-mention-ngram: binds and inactivatest?e1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='reactivation'] >nn [lemma='p53'] controller:Gene_or_gene_productt!interceding-token ngrams: , a CDKt?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p21'] themet(e2: ents2Label-mention-ngram: and causest%interceding-token ngrams: inhibitor .t?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: reactivation upregulatestJe1: trigger-arg-path: upregulates:Positive_activation >dobj >nn controlledt*e1: ents2Label-mention-ngram: reactivationtze1: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='reactivation'] >nn [lemma='p53'] Gene_or_gene_productt-e2: args2Role-mention-ngram: THEME and causest(e2: args2Role-mention-ngram: B and THEMEtje1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='p21'] controlledtKe2: trigger-arg-path: binds >nsubj [lemma='p21'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='p21'] Gene_or_gene_productt?e1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlled:Gene_or_gene_productt3e1: args2Role-mention-ngram: upregulates CONTROLLEDtbe2: trigger-arg-path: binds >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] Sitet8e2: ents2Label-mention-ngram: B and GENE_OR_GENE_PRODUCTt'e2: args2Role-mention-ngram: and causestSe2: trigger-arg-path: binds:Binding >nsubj [lemma='p21'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: Cyclin BtTe1: trigger-arg-path: upregulates:Positive_activation >dobj >nn Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='cdk2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='cdk2'] theme:Gene_or_gene_productt"e2: args2Role-mention-ngram: B andt{e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] Sitet5e1: args2Role-mention-ngram: reactivation upregulatest$e2: ents2Label-mention-ngram: causest2e2: ents2Label-mention-ngram: inactivates Cyclin Bt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='cdk2'] Gene_or_gene_productte1: trigger: upregulatest'e2: ents2Label-mention-ngram: causes G2tQe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn Gene_or_gene_producttinterceding-token ngrams: CDKt#e2: ents2Label-mention-ngram: B andt6e2: trigger-arg-path: Binding >conj_and >dobj >nn sitet)e2: args2Role-mention-ngram: Cyclin B andtpe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn controlled:Gene_or_gene_producttUe1: trigger-arg-path: upregulates:Positive_activation >nsubj >nn Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='cdk2'] theme:Gene_or_gene_productt@e1: args2Role-mention-ngram: CONTROLLER reactivation upregulatest)e1: ents2Label-mention-ngram: upregulatest7e1: trigger-arg-path: upregulates >nsubj >nn controllertee1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn Gene_or_gene_producttje2: trigger-arg-path: binds:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] Sitet?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlled:Gene_or_gene_producttpe1: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controllert^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p21'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controllertte1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='expression'] >nn [lemma='p21'] Gene_or_gene_productt_e1: trigger-arg-path: upregulates:Positive_activation >dobj >nn controlled:Gene_or_gene_producttKe1: trigger-arg-path: upregulates >dobj >nn controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: inactivatest?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reactivationtqe1: trigger-arg-path: upregulates >nsubj [lemma='reactivation'] >nn [lemma='p53'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: and inactivates CyclintRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj >nn site:Sitet6e1: trigger-arg-path: upregulates >dobj >nn controlledt6e2: trigger-arg-path: binds >nsubj [lemma='p21'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] site:Sitetye1: trigger-arg-path: Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controller:Gene_or_gene_productt6e2: trigger-arg-path: Binding >conj_and >dobj >nn Sitetde1: trigger-arg-path: Positive_activation >nsubj [lemma='reactivation'] >nn [lemma='p53'] controllert#e2: args2Role-mention-ngram: causest$e2: ents2Label-mention-ngram: Cyclint3e2: ents2Label-mention-ngram: binds and inactivatestAe2: trigger-arg-path: binds:Binding >conj_and >dobj >nn site:SitetAe1: trigger-arg-path: upregulates >nsubj >nn Gene_or_gene_productt)interceding-token ngrams: a CDK inhibitort[e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj >nn controlledtwe1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: reactivation upregulates SHAREDtVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p21'] Gene_or_gene_producttMe2: trigger-arg-path: Binding >dobj [lemma='cdk2'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: causes SITEt~e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlledtde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p21'] theme:Gene_or_gene_producttve1: trigger-arg-path: Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p21'] theme:Gene_or_gene_producttKe1: trigger-arg-path: upregulates:Positive_activation >nsubj >nn controllertJe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and >dobj >nn site:Sitet'interceding-token ngrams: CDK inhibitortRe1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj >nn Gene_or_gene_productt(e1: args2Role-mention-ngram: upregulatest>e2: trigger-arg-path: binds:Binding >dobj [lemma='cdk2'] themet e2: ents2Label-mention-ngram: G2tme1: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='reactivation'] >nn [lemma='p53'] controllert@e1: args2Role-mention-ngram: reactivation upregulates CONTROLLEDtKe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reactivation upregulatestme1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='expression'] >nn [lemma='p21'] controlledt8e2: trigger-arg-path: Binding >dobj [lemma='cdk2'] themetMe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >conj_and >dobj >nn sitetGe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj >nn controlledtxe2: trigger-arg-path: lemmatizedTrigger=bind >conj_and [lemma='cause'] >dobj [lemma='arrest'] >nn [lemma='g2'] site:Sitete2: args2Role-mention-ngram: Bt(e2: args2Role-mention-ngram: inactivatestKe2: trigger-arg-path: binds >dobj [lemma='cdk2'] theme:Gene_or_gene_productt)interceding-token ngrams: ) . Furthermoret{e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='sirt1'] theme:Gene_or_gene_productt?interceding-tokens-full-span: upon oxidative stress , phosphorylates SIRT1 at Ser27 , Ser47 , and Thr530 , thereby enhancing its nuclear localization ( Nasrin et al. , ) . Furthermore these phosphorylationst?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlledtSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='jnk'] themet*interceding-token ngrams: oxidative stresst8e2: trigger-arg-path: increase >dobj >prep_of controlledt(interceding-token ngrams: upon oxidativet+interceding-token ngrams: Furthermore theset*e2: ents2Label-mention-ngram: increase thet,interceding-token ngrams: oxidative stress ,tee2: trigger-arg-path: increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] Gene_or_gene_productt3e2: args2Role-mention-ngram: increase the enzymatictpe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] Gene_or_gene_productt0interceding-token ngrams: , phosphorylates SIRT1t[e2: trigger-arg-path: increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controllert/interceding-token ngrams: upon oxidative stresstJe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controllertHe1: trigger-arg-path: interacts:Binding >prep_with [lemma='sirt1'] themet+interceding-token ngrams: thereby enhancingtQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sirt1'] themetfe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controllert'interceding-token ngrams: Ser27 , Ser47t"interceding-token ngrams: Thr530 ,tMe2: trigger-arg-path: increase >dobj >prep_of controller:Gene_or_gene_productt$interceding-token ngrams: and Thr530toe2: trigger-arg-path: increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlledt)e2: args2Role-mention-ngram: increase thetIe1: trigger-arg-path: interacts >nsubj [lemma='jnk'] Gene_or_gene_producttLe2: trigger-arg-path: increase:Positive_activation >dobj >prep_of controlledthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='jnk'] theme:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='sirt1'] Gene_or_gene_productt&interceding-token ngrams: and Thr530 ,tMe2: trigger-arg-path: increase >dobj >prep_of controlled:Gene_or_gene_productt!interceding-token ngrams: , Ser47t'interceding-token ngrams: Nasrin et al.t?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controllert"interceding-token ngrams: at Ser27t(interceding-token ngrams: localization (tTe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of Gene_or_gene_productt#interceding-token ngrams: Nasrin ett>e2: ents2Label-mention-ngram: activity of GENE_OR_GENE_PRODUCTt8e2: trigger-arg-path: increase >dobj >prep_of controllert1interceding-token ngrams: phosphorylates SIRT1 attSe1: trigger-arg-path: Binding >prep_with [lemma='sirt1'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='jnk'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sirt1'] Gene_or_gene_producttWe1: trigger-arg-path: interacts:Binding >prep_with [lemma='sirt1'] Gene_or_gene_producttWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='jnk'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: increaset#interceding-token ngrams: oxidativetdobj >prep_of Gene_or_gene_productt(interceding-token ngrams: SIRT1 at Ser27tBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='jnk'] themet%interceding-token ngrams: ( Nasrin ett!interceding-token ngrams: Ser47 ,t interceding-token ngrams: Thr530t"interceding-token ngrams: ( Nasrint/interceding-token ngrams: thereby enhancing itst_e2: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controlled:Gene_or_gene_productt%interceding-token ngrams: its nucleart0interceding-token ngrams: these phosphorylationst^e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controlledt!interceding-token ngrams: Ser27 ,tYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='sirt1'] themet1interceding-token ngrams: stress , phosphorylatest"interceding-token ngrams: SIRT1 att*interceding-token ngrams: phosphorylationstfe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sirt1'] theme:Gene_or_gene_producttoe2: trigger-arg-path: increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controllert-interceding-token ngrams: , thereby enhancingt.interceding-token ngrams: phosphorylates SIRT1tme2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlledtLe2: trigger-arg-path: increase:Positive_activation >dobj >prep_of controllert3e2: args2Role-mention-ngram: activity of CONTROLLERt4e2: ents2Label-mention-ngram: increase the enzymatict#interceding-token ngrams: , Ser47 ,tpe2: trigger-arg-path: increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlled:Gene_or_gene_productt%interceding-token ngrams: Ser47 , andt_e2: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: increasetse2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt"interceding-token ngrams: stress ,tZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='jnk'] Gene_or_gene_productt>e1: trigger-arg-path: Binding >prep_with [lemma='sirt1'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='jnk'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_with [lemma='sirt1'] Gene_or_gene_producttpe2: trigger-arg-path: increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controller:Gene_or_gene_productt8e1: trigger-arg-path: Binding >nsubj [lemma='jnk'] themetinterceding-token ngrams: Ser27tUe1: trigger-arg-path: interacts >prep_with [lemma='sirt1'] theme:Gene_or_gene_producttye2: trigger-arg-path: increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlled:Gene_or_gene_productt.interceding-token ngrams: nuclear localizationt^e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controllertbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='jnk'] Gene_or_gene_producttOe1: trigger-arg-path: interacts >prep_with [lemma='sirt1'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of controller:Gene_or_gene_producttOe1: trigger-arg-path: interacts >nsubj [lemma='jnk'] theme:Gene_or_gene_productte2: trigger: increaset[e2: trigger-arg-path: increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlledtXe2: trigger-arg-path: Positive_activation >dobj >prep_of controller:Gene_or_gene_productt*interceding-token ngrams: , phosphorylatestBe2: trigger-arg-path: increase >dobj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controller:Gene_or_gene_producttCe2: trigger-arg-path: Positive_activation >dobj >prep_of controllertae2: trigger-arg-path: increase:Positive_activation >dobj >prep_of controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controllertJe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >prep_of controlledt-interceding-token ngrams: . Furthermore theset?e2: trigger-arg-path: increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controller:Gene_or_gene_productt$interceding-token ngrams: at Ser27 ,twe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >prep_of [lemma='sirt1'] Gene_or_gene_productt]e1: trigger-arg-path: interacts:Binding >prep_with [lemma='sirt1'] theme:Gene_or_gene_productt{e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlled:Gene_or_gene_productt0interceding-token ngrams: nuclear localization (t?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controller:Gene_or_gene_productt/interceding-token ngrams: localization ( Nasrintae2: trigger-arg-path: increase:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttinterceding-token ngrams: Ser47tQe1: trigger-arg-path: interacts:Binding >nsubj [lemma='jnk'] Gene_or_gene_productt*interceding-token ngrams: Thr530 , therebyt interceding-token ngrams: Nasrintfe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlledt?e2: trigger-arg-path: increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlled:Gene_or_gene_productt@e1: trigger-arg-path: interacts >prep_with [lemma='sirt1'] themetKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='jnk'] themet?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sirt1'] controlled:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >prep_of Gene_or_gene_productt/interceding-token ngrams: enhancing its nucleart&interceding-token ngrams: , and Thr530tGe1: trigger-arg-path: Binding >nsubj [lemma='jnk'] Gene_or_gene_productt:e1: trigger-arg-path: interacts >nsubj [lemma='jnk'] themet2interceding-token ngrams: its nuclear localizationt;e2: trigger-arg-path: interacts >nsubj [lemma='Rheb'] themet;e1: trigger-arg-path: interact >nsubj [lemma='bnip3'] themet$interceding-token ngrams: of mTOR tot!e1: ents2Label-mention-ngram: NIXtFe1: trigger-arg-path: interact:Binding >prep_with [lemma='Rheb'] themet(interceding-token ngrams: a small GTPasetRe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Rheb'] Gene_or_gene_producttWe2: trigger-arg-path: interacts:Binding >prep_with [lemma='bnip3'] Gene_or_gene_producttRe1: trigger-arg-path: interact:Binding >nsubj [lemma='bnip3'] Gene_or_gene_producttinterceding-token ngrams: actstfe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bnip3'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='Rheb'] themet:e1: trigger-arg-path: Binding >nsubj [lemma='bnip3'] themet[e1: trigger-arg-path: interact:Binding >prep_with [lemma='Rheb'] theme:Gene_or_gene_producttHe2: trigger-arg-path: Binding >nsubj [lemma='Rheb'] Gene_or_gene_producttMe2: trigger-arg-path: Binding >prep_with [lemma='bnip3'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: and NIX alsotCe1: trigger-arg-path: interact:Binding >nsubj [lemma='bnip3'] themetUe1: trigger-arg-path: interact:Binding >prep_with [lemma='Rheb'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bnip3'] Gene_or_gene_productt&interceding-token ngrams: promote cellt@e2: trigger-arg-path: interacts >prep_with [lemma='bnip3'] themet#interceding-token ngrams: that actst%e1: args2Role-mention-ngram: NIX alsot$e1: args2Role-mention-ngram: and NIXt0interceding-token ngrams: positively upstream oftXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='Rheb'] themet*interceding-token ngrams: GTPase that actstYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bnip3'] themetOe1: trigger-arg-path: Binding >nsubj [lemma='bnip3'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: NIX alsot-interceding-token ngrams: promote cell growtht\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='bnip3'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Rheb'] themetje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='bnip3'] theme:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bnip3'] theme:Gene_or_gene_productt2interceding-token ngrams: acts positively upstreamt)interceding-token ngrams: acts positivelyt e1: args2Role-mention-ngram: NIXtUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='bnip3'] themet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='Rheb'] Gene_or_gene_productt&interceding-token ngrams: small GTPasetNe2: trigger-arg-path: Binding >nsubj [lemma='Rheb'] theme:Gene_or_gene_productt)interceding-token ngrams: to promote celltOe2: trigger-arg-path: interacts >prep_with [lemma='bnip3'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: and NIXthe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bnip3'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='bnip3'] Gene_or_gene_productt'interceding-token ngrams: cell growth .tLe1: trigger-arg-path: Binding >prep_with [lemma='Rheb'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bnip3'] themet.e1: args2Role-mention-ngram: NIX also interactt%interceding-token ngrams: cell growtht>e2: trigger-arg-path: Binding >prep_with [lemma='bnip3'] themet)interceding-token ngrams: mTOR to promotet%interceding-token ngrams: GTPase thattPe1: trigger-arg-path: interact >nsubj [lemma='bnip3'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Rheb'] Gene_or_gene_producttMe1: trigger-arg-path: interact >prep_with [lemma='Rheb'] Gene_or_gene_productt!interceding-token ngrams: a smalltXe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Rheb'] theme:Gene_or_gene_producttHe2: trigger-arg-path: interacts:Binding >prep_with [lemma='bnip3'] themet+interceding-token ngrams: small GTPase thatt>e1: trigger-arg-path: interact >prep_with [lemma='Rheb'] themetminterceding-tokens-full-span: , a small GTPase that acts positively upstream of mTOR to promote cell growth .t*interceding-token ngrams: upstream of mTORtSe1: trigger-arg-path: interact >prep_with [lemma='Rheb'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Rheb'] theme:Gene_or_gene_productt-interceding-token ngrams: positively upstreamtee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='Rheb'] theme:Gene_or_gene_productt#interceding-token ngrams: , a smallt,e1: ents2Label-mention-ngram: SHARED and NIXtie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Rheb'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_with [lemma='bnip3'] theme:Gene_or_gene_productt!interceding-token ngrams: mTOR tot$interceding-token ngrams: positivelytTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Rheb'] themetUe2: trigger-arg-path: interacts >prep_with [lemma='bnip3'] theme:Gene_or_gene_productt]e2: trigger-arg-path: interacts:Binding >prep_with [lemma='bnip3'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interact >nsubj [lemma='bnip3'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='Rheb'] themetMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='bnip3'] themetIe1: trigger-arg-path: Binding >nsubj [lemma='bnip3'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='bnip3'] theme:Gene_or_gene_producttinterceding-token ngrams: smalltRe1: trigger-arg-path: Binding >prep_with [lemma='Rheb'] theme:Gene_or_gene_producttJe2: trigger-arg-path: interacts >nsubj [lemma='Rheb'] Gene_or_gene_productt)e1: args2Role-mention-ngram: and NIX alsot/e1: ents2Label-mention-ngram: NIX also interacttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='Rheb'] Gene_or_gene_producttPe2: trigger-arg-path: interacts >nsubj [lemma='Rheb'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME and NIXt=e1: trigger-arg-path: Binding >prep_with [lemma='Rheb'] themetme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='Rheb'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Rheb'] themet.interceding-token ngrams: that acts positivelyt[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Rheb'] Gene_or_gene_producttXe1: trigger-arg-path: interact:Binding >nsubj [lemma='bnip3'] theme:Gene_or_gene_productt)interceding-token ngrams: mutation in thet#interceding-token ngrams: region oft*interceding-token ngrams: and inhibits itst(interceding-token ngrams: the BIR domaint(interceding-token ngrams: BIR domain cant'interceding-token ngrams: Smac , DIABLOt^e2: trigger-arg-path: interactions >prep_between [lemma='survivin'] theme:Gene_or_gene_producttinterceding-token ngrams: Smact interceding-token ngrams: the Znt`e2: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] Gene_or_gene_productt2interceding-token ngrams: and subsequently inhibittbe2: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] theme:Gene_or_gene_productt(interceding-token ngrams: disrupt the Znt'interceding-token ngrams: from the SmactEinterceding-tokens-full-span: and DIABLO and inhibits its pro-apoptotic functions through releasing of XIAP from the Smac , DIABLO and XIAP complex to inhibit various caspases . In theory , C84A mutation in the extreme C-terminal region of the BIR domain can disrupt the Zn 2+ coordination sphere and subsequently inhibit thetAe1: trigger-arg-path: binds:Binding >prep_to [lemma='Smac'] themetae1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='survivin'] theme:Gene_or_gene_productt,interceding-token ngrams: complex to inhibitt;e1: trigger-arg-path: Binding >prep_to [lemma='Smac'] themet1interceding-token ngrams: pro-apoptotic functionst,interceding-token ngrams: to inhibit varioustXe1: trigger-arg-path: binds:Binding >nsubj [lemma='survivin'] theme:Gene_or_gene_productt$interceding-token ngrams: C-terminaltNe1: trigger-arg-path: binds >prep_to [lemma='Smac'] theme:Gene_or_gene_productt!interceding-token ngrams: of XIAPtinterceding-token ngrams: Znt4interceding-token ngrams: inhibits its pro-apoptotict*interceding-token ngrams: various caspasest$interceding-token ngrams: and DIABLOt1interceding-token ngrams: coordination sphere andt#interceding-token ngrams: the Zn 2+tEe2: trigger-arg-path: interactions >prep_between [lemma='smac'] themet'interceding-token ngrams: theory , C84At interceding-token ngrams: DIABLOt interceding-token ngrams: spheretXe2: trigger-arg-path: interactions >prep_between [lemma='survivin'] Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='Smac'] Gene_or_gene_productt*interceding-token ngrams: C84A mutation int_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Smac'] theme:Gene_or_gene_productt%interceding-token ngrams: mutation int*interceding-token ngrams: and XIAP complextRe1: trigger-arg-path: Binding >nsubj [lemma='survivin'] theme:Gene_or_gene_productt#interceding-token ngrams: In theoryt'interceding-token ngrams: C84A mutationtZe2: trigger-arg-path: interactions >prep_between [lemma='smac'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='Smac'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Smac'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='Smac'] Gene_or_gene_producttQe2: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] themet.interceding-token ngrams: C-terminal region oftYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Smac'] Gene_or_gene_productt%interceding-token ngrams: . In theoryt"interceding-token ngrams: caspasest.interceding-token ngrams: through releasing oft&interceding-token ngrams: of XIAP fromt[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='survivin'] Gene_or_gene_productt!interceding-token ngrams: the BIRtRe1: trigger-arg-path: binds:Binding >nsubj [lemma='survivin'] Gene_or_gene_productt&interceding-token ngrams: XIAP complext9interceding-token ngrams: pro-apoptotic functions throught5interceding-token ngrams: its pro-apoptotic functionstie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='survivin'] theme:Gene_or_gene_productt,interceding-token ngrams: domain can disruptt2interceding-token ngrams: subsequently inhibit thetCe1: trigger-arg-path: binds:Binding >nsubj [lemma='survivin'] themet9e1: trigger-arg-path: binds >prep_to [lemma='Smac'] themet%interceding-token ngrams: can disruptt(interceding-token ngrams: in the extremet5interceding-token ngrams: functions through releasingt+interceding-token ngrams: its pro-apoptotict!interceding-token ngrams: varioust=e1: trigger-arg-path: Binding >nsubj [lemma='survivin'] themet+interceding-token ngrams: through releasingtfe2: trigger-arg-path: interactions:Binding >prep_between [lemma='survivin'] theme:Gene_or_gene_producttLe1: trigger-arg-path: Binding >nsubj [lemma='survivin'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='survivin'] themet"interceding-token ngrams: the Smact0interceding-token ngrams: the extreme C-terminalt&CSSPATH: ROOT  ++ ROOT >conj_and >dobjt$interceding-token ngrams: BIR domaint)interceding-token ngrams: , C84A mutationt%interceding-token ngrams: disrupt thet,interceding-token ngrams: Zn 2+ coordinationtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Smac'] themet)interceding-token ngrams: DIABLO and XIAPt;e1: trigger-arg-path: binds >nsubj [lemma='survivin'] themetPe1: trigger-arg-path: binds >nsubj [lemma='survivin'] theme:Gene_or_gene_productt'interceding-token ngrams: caspases . IntTe2: trigger-arg-path: interactions >prep_between [lemma='smac'] Gene_or_gene_productt$interceding-token ngrams: caspases .t&interceding-token ngrams: releasing oft&interceding-token ngrams: , DIABLO andtPe1: trigger-arg-path: binds:Binding >prep_to [lemma='Smac'] Gene_or_gene_productt+interceding-token ngrams: releasing of XIAPtinterceding-token ngrams: Zn 2+t\e2: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] Gene_or_gene_productt(interceding-token ngrams: and DIABLO andtge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Smac'] theme:Gene_or_gene_productt$interceding-token ngrams: sphere andt*interceding-token ngrams: and subsequentlyt"interceding-token ngrams: theory ,tinterceding-token ngrams: BIRtLe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='survivin'] themet$interceding-token ngrams: the Smac ,t$interceding-token ngrams: domain cant!interceding-token ngrams: extremetRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Smac'] themetVe1: trigger-arg-path: binds:Binding >prep_to [lemma='Smac'] theme:Gene_or_gene_productt"interceding-token ngrams: and XIAPtinterceding-token ngrams: XIAPt interceding-token ngrams: , C84At#interceding-token ngrams: XIAP fromt-interceding-token ngrams: DIABLO and inhibitst'interceding-token ngrams: region of thet3interceding-token ngrams: extreme C-terminal regiontMe2: trigger-arg-path: interactions:Binding >prep_between [lemma='smac'] themet"interceding-token ngrams: , DIABLOtce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='survivin'] Gene_or_gene_producttJe1: trigger-arg-path: binds >nsubj [lemma='survivin'] Gene_or_gene_producttIe2: trigger-arg-path: interactions >prep_between [lemma='survivin'] themet#interceding-token ngrams: releasingt+interceding-token ngrams: C-terminal regiont$interceding-token ngrams: of the BIRt)interceding-token ngrams: inhibit varioust interceding-token ngrams: theoryt,interceding-token ngrams: extreme C-terminalt)interceding-token ngrams: can disrupt thet)interceding-token ngrams: XIAP complex tot-interceding-token ngrams: coordination spheret+interceding-token ngrams: functions throught0interceding-token ngrams: 2+ coordination spheret'interceding-token ngrams: pro-apoptotict1interceding-token ngrams: sphere and subsequentlyt%interceding-token ngrams: the extremet,interceding-token ngrams: various caspases .t&interceding-token ngrams: subsequentlyt)interceding-token ngrams: 2+ coordinationt2interceding-token ngrams: inhibit various caspasest%interceding-token ngrams: In theory ,t.interceding-token ngrams: subsequently inhibitt interceding-token ngrams: Smac ,t$interceding-token ngrams: DIABLO andt'interceding-token ngrams: XIAP from thet&interceding-token ngrams: coordinationt?e1: trigger-arg-path: binding:Binding nsubj [lemma='nleh1'] Gene_or_gene_producttOe1: trigger-arg-path: binding:Binding nsubj theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: are alsot8e1: trigger-arg-path: binding nsubj themet/e1: ents2Label-mention-ngram: of binding SHAREDt"e1: args2Role-mention-ngram: NleH2tNe1: trigger-arg-path: binding nsubj theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: and NleH2 aretWe1: trigger-arg-path: lemmatizedTrigger=bind nsubj Gene_or_gene_productt8e1: trigger-arg-path: binding nsubj Gene_or_gene_productt+e1: args2Role-mention-ngram: NleH2 are alsot]e1: trigger-arg-path: lemmatizedTrigger=bind nsubj theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: of bindingt-e1: args2Role-mention-ngram: are also capablet?e1: trigger-arg-path: binding:Binding nsubj [lemma='nleh1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='nleh1'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binding:Binding nsubj Gene_or_gene_productt&interceding-token ngrams: their kinaset/e1: args2Role-mention-ngram: capable of bindingt'e1: args2Role-mention-ngram: of bindingt#e1: ents2Label-mention-ngram: NleH2t?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='nleh1'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: also capablet&e1: args2Role-mention-ngram: NleH2 aretVe1: trigger-arg-path: lemmatizedTrigger=bind amodt,interceding-token ngrams: activity . Bindingt,e1: ents2Label-mention-ngram: binding SHAREDt,e1: args2Role-mention-ngram: THEME and NleH2tMe1: trigger-arg-path: binding nsubj [lemma='nleh1'] Gene_or_gene_producttNe1: trigger-arg-path: Binding nsubj theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='nleh1'] Gene_or_gene_productt$interceding-token ngrams: Binding oftye1: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='nleh1'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind nsubj themet0e1: ents2Label-mention-ngram: capable of bindingt.interceding-token ngrams: independent of theirte1: trigger-arg-path: binding nsubj Gene_or_gene_producttUe1: trigger-arg-path: binding:Binding nsubj theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: and NleH2 aret$e1: args2Role-mention-ngram: capablet9e1: trigger-arg-path: binding nsubj themet)e1: trigger-arg-path: Binding nsubj themetGe1: trigger-arg-path: binding nsubj [lemma='nleh1'] themetre1: trigger-arg-path: binding:Binding nsubj [lemma='nleh1'] themet?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='nleh1'] themet'e1: args2Role-mention-ngram: capable oft%e1: ents2Label-mention-ngram: capablet@e1: trigger-arg-path: binding:Binding e1: trigger-arg-path: Binding nsubj [lemma='nleh1'] theme:Gene_or_gene_productt8e1: trigger-arg-path: Binding nsubj [lemma='nleh1'] theme:Gene_or_gene_productt)interceding-token ngrams: of their kinaset8e1: trigger-arg-path: Binding nsubj Gene_or_gene_producttye1: trigger-arg-path: binding nsubj [lemma='nleh1'] Gene_or_gene_productt,e1: args2Role-mention-ngram: also capable oftFe1: trigger-arg-path: binding:Binding prep_of >amod ++ ROOT t*e1: args2Role-mention-ngram: binding THEMEt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='nleh1'] theme:Gene_or_gene_productt"interceding-token ngrams: of theirtje1: trigger-arg-path: binding nsubj [lemma='nleh1'] themetPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj themet.e1: ents2Label-mention-ngram: are also capabletGe1: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='rsk2'] Gene_or_gene_producttKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylation promotest?e2: trigger-arg-path: mediated >nsubj [lemma='rsk2'] controllertSe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] controllert;e2: ents2Label-mention-ngram: mediated GENE_OR_GENE_PRODUCTt]e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttKe2: ents2Label-mention-ngram: mediated GENE_OR_GENE_PRODUCT phosphorylationtPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] controllertye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttTe2: trigger-arg-path: mediated >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] controllerthe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt?interceding-tokens-full-span: and MOZ has not been as well studied as that for p300 and CBP , PCAF and Tip60 . MOF is positively regulated toward p53 thru its interaction with MSL1v1 , which stabilizes thet"interceding-token ngrams: . MOF ist'interceding-token ngrams: that for p300t5e2: trigger-arg-path: Binding >nn [lemma='mof'] themet'interceding-token ngrams: with MSL1v1 ,tACSSPATH: ROOT >nsubjpass >prep_of ++ ROOT >prep_with >rcmod >dobjtSe1: trigger-arg-path: acetylation:Positive_regulation >prep_by Gene_or_gene_productt"interceding-token ngrams: that fortGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mof'] themet5interceding-token ngrams: positively regulated towardt1interceding-token ngrams: is positively regulatedtJe1: trigger-arg-path: acetylation >prep_by controller:Gene_or_gene_productt interceding-token ngrams: , PCAFt!interceding-token ngrams: Tip60 .t%interceding-token ngrams: and MOZ hastse1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by [lemma='mof'] Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='mof'] Gene_or_gene_productt!interceding-token ngrams: as thatt#interceding-token ngrams: and CBP ,t[e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by controllert%interceding-token ngrams: Tip60 . MOFt$interceding-token ngrams: studied ast"interceding-token ngrams: for p300t$interceding-token ngrams: , PCAF andt!interceding-token ngrams: studiedtRe2: trigger-arg-path: complex:Binding >nn [lemma='mof'] theme:Gene_or_gene_productt(interceding-token ngrams: MSL1v1 , whicht%interceding-token ngrams: and Tip60 .t5e2: trigger-arg-path: complex >nn [lemma='mof'] themetinterceding-token ngrams: MOZt$interceding-token ngrams: CBP , PCAFtUe1: trigger-arg-path: Positive_regulation >prep_by [lemma='mof'] Gene_or_gene_productt*interceding-token ngrams: which stabilizest?e1: trigger-arg-path: acetylation >prep_by Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mof'] Gene_or_gene_producttinterceding-token ngrams: PCAFt,interceding-token ngrams: , which stabilizest`e1: trigger-arg-path: Positive_regulation >prep_by [lemma='mof'] controller:Gene_or_gene_productt%interceding-token ngrams: MOZ has nott interceding-token ngrams: towardt"interceding-token ngrams: p53 thrut!interceding-token ngrams: been astje1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by [lemma='mof'] controller:Gene_or_gene_productt interceding-token ngrams: MSL1v1t"interceding-token ngrams: thru itst"interceding-token ngrams: PCAF andt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mof'] Gene_or_gene_producttKe1: trigger-arg-path: Positive_regulation >prep_by [lemma='mof'] controllert.interceding-token ngrams: positively regulatedt~e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by [lemma='mof'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by [lemma='mof'] controllert)interceding-token ngrams: as well studiedt$interceding-token ngrams: toward p53t)interceding-token ngrams: toward p53 thrut&interceding-token ngrams: been as wellt!interceding-token ngrams: and MOZt*interceding-token ngrams: regulated towardt(interceding-token ngrams: stabilizes thetCe1: trigger-arg-path: acetylation >prep_by [lemma='mof'] controllert.interceding-token ngrams: which stabilizes thetQe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by controllert&interceding-token ngrams: well studiedt3e1: ents2Label-mention-ngram: SHARED acetylation byt'interceding-token ngrams: is positivelyt"interceding-token ngrams: p300 andt3e1: ents2Label-mention-ngram: acetylation by SHAREDt"interceding-token ngrams: MSL1v1 ,t.interceding-token ngrams: regulated toward p53tae1: trigger-arg-path: acetylation:Positive_regulation >prep_by [lemma='mof'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='mof'] themetle1: trigger-arg-path: acetylation:Positive_regulation >prep_by [lemma='mof'] controller:Gene_or_gene_productt1interceding-token ngrams: interaction with MSL1v1t)interceding-token ngrams: well studied ast5e1: trigger-arg-path: acetylation >prep_by controllert&interceding-token ngrams: for p300 andtinterceding-token ngrams: CBPtUe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by [lemma='mof'] controllertOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mof'] themet$interceding-token ngrams: stabilizest interceding-token ngrams: MOF istWe1: trigger-arg-path: acetylation:Positive_regulation >prep_by [lemma='mof'] controllert!interceding-token ngrams: and CBPtIe1: trigger-arg-path: acetylation:Positive_regulation >prep_by controllertinterceding-token ngrams: thrut+interceding-token ngrams: MOF is positivelytXe1: trigger-arg-path: acetylation >prep_by [lemma='mof'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by [lemma='mof'] Gene_or_gene_productt(interceding-token ngrams: PCAF and Tip60t)interceding-token ngrams: studied as thatt\e1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_by controller:Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='mof'] Gene_or_gene_productt!interceding-token ngrams: MOZ hastinterceding-token ngrams: . MOFt%interceding-token ngrams: with MSL1v1t.interceding-token ngrams: thru its interactiont%interceding-token ngrams: as that fortMe1: trigger-arg-path: acetylation >prep_by [lemma='mof'] Gene_or_gene_producttinterceding-token ngrams: MOFt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mof'] theme:Gene_or_gene_producttinterceding-token ngrams: CBP ,tee1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_by controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mof'] theme:Gene_or_gene_productt&interceding-token ngrams: p53 thru itstDe2: trigger-arg-path: Binding >nn [lemma='mof'] Gene_or_gene_productt%interceding-token ngrams: not been astJe2: trigger-arg-path: Binding >nn [lemma='mof'] theme:Gene_or_gene_productt^e1: trigger-arg-path: acetylation:Positive_regulation >prep_by controller:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='mof'] theme:Gene_or_gene_productt&interceding-token ngrams: p300 and CBPt/interceding-token ngrams: interest to elucidatet&interceding-token ngrams: PI3K and IIIt%interceding-token ngrams: preceded byt%interceding-token ngrams: and if thistinterceding-token ngrams: 1 ast$interceding-token ngrams: as adaptort'interceding-token ngrams: the mentionedtqe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj >agent controller:Gene_or_gene_producttme2: trigger-arg-path: Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] Gene_or_gene_producttme2: trigger-arg-path: mediated >csubj [lemma='precede'] >agent [lemma='ulk1'] controller:Gene_or_gene_productt,interceding-token ngrams: as adaptor proteintfe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj >agent Gene_or_gene_productt"interceding-token ngrams: would bet7e2: trigger-arg-path: mediated >csubj >agent controllert-interceding-token ngrams: adaptor protein andt$CSSPATH: ROOT  ++ ROOT >xcomp >advclt"interceding-token ngrams: interestt(interceding-token ngrams: elucidate , ift&e1: ents2Label-mention-ngram: at Ser14t&interceding-token ngrams: Finally , itt"interceding-token ngrams: by TRAF6t5interceding-token ngrams: linked polyubquitination oft)interceding-token ngrams: and III complext*interceding-token ngrams: complex activityt*interceding-token ngrams: requires Ambra 1tVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] controllertinterceding-token ngrams: , ift1interceding-token ngrams: observed in macrophagest,e2: ents2Label-mention-ngram: of both SHAREDt interceding-token ngrams: linkedtinterceding-token ngrams: TRAF6txe2: trigger-arg-path: Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controller:Gene_or_gene_productt%interceding-token ngrams: interest totve2: trigger-arg-path: mediated:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] Gene_or_gene_productt%interceding-token ngrams: it would betinterceding-token ngrams: Lys63t`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] Gene_or_gene_productt$interceding-token ngrams: 1 by TRAF6t`e2: trigger-arg-path: mediated:Positive_regulation >csubj >agent controller:Gene_or_gene_productt%interceding-token ngrams: of Beclin 1t"interceding-token ngrams: precededt\e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj >agent controllert%interceding-token ngrams: higher PI3Kt8interceding-token ngrams: Lys63 linked polyubquitinationt*interceding-token ngrams: the Lys63 linkedtie2: trigger-arg-path: lemmatizedTrigger=mediate >csubj [lemma='precede'] >agent [lemma='ulk1'] controllertbe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_productt&interceding-token ngrams: Lys63 linkedtme1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_producttinterceding-token ngrams: IIIt%interceding-token ngrams: in a highertLe2: trigger-arg-path: mediated >csubj >agent controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controllert%interceding-token ngrams: elucidate ,t(interceding-token ngrams: in macrophagestinterceding-token ngrams: ift)e2: ents2Label-mention-ngram: both SHAREDt:interceding-tokens-full-span: , resulting in a higher PI3K and III complex activity . Finally , it would be of interest to elucidate , if also the Lys63 linked polyubquitination of Beclin 1 by TRAF6 observed in macrophages requires Ambra 1 as adaptor protein and if this ubiquitination is preceded by the mentionedt4interceding-token ngrams: macrophages requires Ambrat%interceding-token ngrams: is precededtinterceding-token ngrams: be oft,interceding-token ngrams: activity . Finallytse2: trigger-arg-path: lemmatizedTrigger=mediate >csubj [lemma='precede'] >agent [lemma='ulk1'] Gene_or_gene_productt%interceding-token ngrams: of interestt'interceding-token ngrams: a higher PI3Kt#e1: ents2Label-mention-ngram: Ser14t"interceding-token ngrams: PI3K andt0interceding-token ngrams: if this ubiquitinationt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] Gene_or_gene_productt$interceding-token ngrams: , it wouldt%interceding-token ngrams: III complextXe2: trigger-arg-path: mediated >csubj [lemma='precede'] >agent [lemma='ulk1'] controllert-interceding-token ngrams: this ubiquitinationt+interceding-token ngrams: ubiquitination ist)interceding-token ngrams: preceded by thet+interceding-token ngrams: by TRAF6 observedtce2: trigger-arg-path: Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controllert#interceding-token ngrams: of Beclint6e1: ents2Label-mention-ngram: SHARED can phosphorylatetDe1: trigger-arg-path: phosphorylate >nsubj [lemma='ulk1'] controllert%interceding-token ngrams: Beclin 1 byt.interceding-token ngrams: polyubquitination oft(interceding-token ngrams: requires Ambrat(interceding-token ngrams: of interest totTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: 1 at Ser14t~e2: trigger-arg-path: lemmatizedTrigger=mediate >csubj [lemma='precede'] >agent [lemma='ulk1'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: phosphorylate SHARED 1t(interceding-token ngrams: to elucidate ,t!interceding-token ngrams: and IIIt(interceding-token ngrams: be of interestt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controller:Gene_or_gene_productt+interceding-token ngrams: TRAF6 observed intbe2: trigger-arg-path: mediated >csubj [lemma='precede'] >agent [lemma='ulk1'] Gene_or_gene_productt"interceding-token ngrams: it wouldt(interceding-token ngrams: protein and iftinterceding-token ngrams: 1 bytRe2: trigger-arg-path: lemmatizedTrigger=mediate >csubj >agent Gene_or_gene_producttYe1: trigger-arg-path: phosphorylate >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt!interceding-token ngrams: Ambra 1t5interceding-token ngrams: polyubquitination of Beclint}e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controllert(interceding-token ngrams: also the Lys63t"interceding-token ngrams: also thet4interceding-token ngrams: ubiquitination is precededtJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] controllertle2: trigger-arg-path: mediated:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controllert6e1: ents2Label-mention-ngram: can phosphorylate SHAREDtWe2: trigger-arg-path: Positive_regulation >csubj >agent controller:Gene_or_gene_productt.interceding-token ngrams: macrophages requirest#interceding-token ngrams: the Lys63t#interceding-token ngrams: elucidatet!interceding-token ngrams: if alsotBe2: trigger-arg-path: Positive_regulation >csubj >agent controllert,interceding-token ngrams: complex activity .tXe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controllert)interceding-token ngrams: higher PI3K andt!interceding-token ngrams: if thist&interceding-token ngrams: 1 as adaptortinterceding-token ngrams: Ambrat)e1: ents2Label-mention-ngram: SHARED 1 attLe2: trigger-arg-path: Positive_regulation >csubj >agent Gene_or_gene_producttinterceding-token ngrams: wouldtKe2: trigger-arg-path: mediated:Positive_regulation >csubj >agent controllert interceding-token ngrams: and ifte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt%interceding-token ngrams: if also thet%interceding-token ngrams: protein andt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_producttAe2: trigger-arg-path: mediated >csubj >agent Gene_or_gene_productt"e1: ents2Label-mention-ngram: 1 attNe1: trigger-arg-path: phosphorylate >nsubj [lemma='ulk1'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_regulation >csubj [lemma='precede'] >agent [lemma='ulk1'] controller:Gene_or_gene_productt#interceding-token ngrams: , if alsot/e1: ents2Label-mention-ngram: can phosphorylatet0interceding-token ngrams: this ubiquitination istUe2: trigger-arg-path: mediated:Positive_regulation >csubj >agent Gene_or_gene_productt2interceding-token ngrams: linked polyubquitinationt+interceding-token ngrams: polyubquitinationt(interceding-token ngrams: TRAF6 observedt]e2: trigger-arg-path: lemmatizedTrigger=mediate >csubj >agent controller:Gene_or_gene_productt(interceding-token ngrams: is preceded byt*interceding-token ngrams: by the mentionedtte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_productt1interceding-token ngrams: in macrophages requirest%interceding-token ngrams: would be oft$interceding-token ngrams: Ambra 1 astke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] controller:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=mediate >csubj >agent controllert5e2: ents2Label-mention-ngram: phosphorylation of botht&interceding-token ngrams: to elucidatet.interceding-token ngrams: III complex activityt'e1: ents2Label-mention-ngram: JNK , p38t?e1: trigger-arg-path: Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controller:Gene_or_gene_productt;e2: args2Role-mention-ngram: CONTROLLER signaling decreasedtCe1: trigger-arg-path: phosphorylate agent >appos controllert#interceding-token ngrams: for GSK-3t,e1: args2Role-mention-ngram: ) to CONTROLLEDtinterceding-token ngrams: GSK-3t5e2: trigger-arg-path: decreased >nsubj >nn controllert!e1: ents2Label-mention-ngram: p38tre1: trigger-arg-path: phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] controllert]e2: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] FamilytEe2: trigger-arg-path: decreased:Negative_regulation >nsubj >nn Familyt?e1: trigger-arg-path: phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: ) totPe2: trigger-arg-path: decreased:Negative_regulation >nsubj >nn controller:Familyt0e1: ents2Label-mention-ngram: ) to phosphorylatet1e2: trigger-arg-path: decreased >nsubj >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] controller:Gene_or_gene_producttke2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllertde2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] FamilytMe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn controller:Familyt$e1: args2Role-mention-ngram: , JNK ,tFe2: trigger-arg-path: Negative_regulation >nsubj >nn controller:Familytae2: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllert^e1: trigger-arg-path: Positive_regulation agent >appos controller:Gene_or_gene_productt e1: args2Role-mention-ngram: JNKtUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent >appos controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] Gene_or_gene_producttae1: trigger-arg-path: phosphorylate:Positive_regulation agent >appos Gene_or_gene_producttFe2: ents2Label-mention-ngram: signaling decreased GENE_OR_GENE_PRODUCTtXe1: trigger-arg-path: phosphorylate agent >appos controller:Gene_or_gene_productt*interceding-token ngrams: GSK-3 activity .t)interceding-token ngrams: was most likelyt.interceding-token ngrams: most likely requiredt,interceding-token ngrams: for GSK-3 activityt(interceding-token ngrams: GSK-3 activityt&e1: args2Role-mention-ngram: MAPK ) tot"e1: args2Role-mention-ngram: , JNKt"interceding-token ngrams: was mostt1e2: ents2Label-mention-ngram: signaling decreasedthe2: trigger-arg-path: Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt%e1: ents2Label-mention-ngram: , JNK ,t#e1: ents2Label-mention-ngram: , JNKt;e2: trigger-arg-path: Negative_regulation >nsubj >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] controllert8e2: ents2Label-mention-ngram: FAMILY signaling decreasedt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , JNKt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent >appos Gene_or_gene_productt?e1: trigger-arg-path: phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: MAPK ) totxe1: trigger-arg-path: Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controllertIe2: trigger-arg-path: decreased:Negative_regulation >nsubj >nn controllert,interceding-token ngrams: required for GSK-3t%e1: args2Role-mention-ngram: p38 MAPKt1e2: args2Role-mention-ngram: CONTROLLER signalingtSe1: trigger-arg-path: Positive_regulation agent >appos Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent >appos controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: CONTROLLER , JNKtMe1: trigger-arg-path: phosphorylate agent >appos Gene_or_gene_productt&e1: ents2Label-mention-ngram: p38 MAPKt|e1: trigger-arg-path: phosphorylate agent [lemma='mapk'] >appos [lemma='erk'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn controller:FamilytVe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn FamilytWe2: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllert e1: args2Role-mention-ngram: p38the2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] controllertIe1: trigger-arg-path: Positive_regulation agent >appos controllert~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent >appos controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate agent >appos controller:Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] Gene_or_gene_producttSe2: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familyt^e2: trigger-arg-path: decreased >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt-interceding-token ngrams: likely required fortKinterceding-tokens-full-span: was most likely required for GSK-3 activity .tnsubj [lemma='signaling'] >nn [lemma='wnt'] controllert&e1: args2Role-mention-ngram: JNK , p38t0e2: args2Role-mention-ngram: signaling decreasedtxe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familyt'e1: args2Role-mention-ngram: , p38 MAPKtge2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] Familytse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent >appos Gene_or_gene_producttnsubj >nn controller:Familytre2: trigger-arg-path: decreased:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt"e1: args2Role-mention-ngram: , p38t)interceding-token ngrams: likely requiredt*CSSPATH: ROOT >nsubj >vmod >xcomp ++ ROOT tLe2: ents2Label-mention-ngram: decreased GENE_OR_GENE_PRODUCT phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt#e1: ents2Label-mention-ngram: , p38t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: , p38 MAPKt?e1: trigger-arg-path: phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controllert"e1: args2Role-mention-ngram: JNK ,t.e2: ents2Label-mention-ngram: FAMILY signalingt#e1: ents2Label-mention-ngram: JNK ,t!e1: ents2Label-mention-ngram: JNKtoe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='signaling'] >nn [lemma='wnt'] controller:Familyt;e2: args2Role-mention-ngram: signaling decreased CONTROLLEDtBe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn Familyt'e1: args2Role-mention-ngram: p38 MAPK )t(e1: ents2Label-mention-ngram: p38 MAPK )t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controllert?e1: trigger-arg-path: phosphorylate:Positive_regulation agent [lemma='mapk'] >appos [lemma='erk'] controller:Gene_or_gene_producttWe1: trigger-arg-path: phosphorylate:Positive_regulation agent >appos controllertle1: trigger-arg-path: phosphorylate:Positive_regulation agent >appos controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=decrease:Negative_regulation >nsubj >nn controllertFe2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn controllert%interceding-token ngrams: the alreadyt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controller:Gene_or_gene_producttEe2: trigger-arg-path: abrogated:Negative_regulation >nsubj controllert.interceding-token ngrams: increase phospho-p70tke2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj [lemma='phosphorylation'] controlled:PhosphorylationtOe2: trigger-arg-path: abrogated >nsubj [lemma='salirasib'] Gene_or_gene_productt"interceding-token ngrams: in HepG2tnsubj controller:Gene_or_gene_producttle1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtve1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj Phosphorylationtye1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controller:Gene_or_gene_productt%interceding-token ngrams: cells , butte2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj [lemma='salirasib'] controller:Gene_or_gene_producttbe1: trigger-arg-path: induced >nsubj [lemma='stimulation'] >nn [lemma='igf2'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj controlled:PhosphorylationtXe1: trigger-arg-path: induced >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controllert,interceding-token ngrams: phospho-p70 levelst'interceding-token ngrams: high baselinetYe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] controlledt%interceding-token ngrams: phospho-p70tme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt5interceding-token ngrams: increase phospho-p70 levelstUe2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj controlledt'interceding-token ngrams: Hep3B cells ,tZe2: trigger-arg-path: abrogated >nsubj [lemma='salirasib'] controller:Gene_or_gene_productt?interceding-tokens-full-span: in HepG2 and Hep3B cells , but did not further increase phospho-p70 levels above the already high baseline expression in Huh7 . Importantly ,t`e2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj [lemma='phosphorylation'] PhosphorylationtJe2: trigger-arg-path: abrogated >dobj [lemma='phosphorylation'] controlledtnsubj >nn Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj [lemma='salirasib'] controllert-interceding-token ngrams: baseline expressiontae1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt[e2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj [lemma='phosphorylation'] controlledtne1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='salirasib'] Gene_or_gene_productt)interceding-token ngrams: did not furthert;e1: args2Role-mention-ngram: CONTROLLER stimulation inducedt}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controllert#interceding-token ngrams: above thet.e2: ents2Label-mention-ngram: abrogated SHAREDtee2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj controlled:Phosphorylationtie1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controllertFe2: trigger-arg-path: abrogated >nsubj controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj controller:Gene_or_gene_producttAe2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj controlledtoe2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj [lemma='phosphorylation'] controlledtQe1: trigger-arg-path: induced:Positive_regulation >nsubj >nn Gene_or_gene_productt+interceding-token ngrams: above the alreadyt.interceding-token ngrams: not further increaset8e1: ents2Label-mention-ngram: stimulation induced SHAREDt\e1: trigger-arg-path: induced:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt;e2: trigger-arg-path: abrogated >nsubj Gene_or_gene_producttinterceding-token ngrams: Hep3Bt)interceding-token ngrams: HepG2 and Hep3Btde2: trigger-arg-path: Negative_regulation >nsubj [lemma='salirasib'] controller:Gene_or_gene_productt)interceding-token ngrams: and Hep3B cellst?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] Gene_or_gene_producttMe1: trigger-arg-path: induced >dobj [lemma='phosphorylation'] PhosphorylationtLe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj Gene_or_gene_producttYe2: trigger-arg-path: abrogated:Negative_regulation >nsubj [lemma='salirasib'] controllertIe2: trigger-arg-path: abrogated:Negative_regulation >dobj Phosphorylationtce2: trigger-arg-path: abrogated:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt>e2: ents2Label-mention-ngram: abrogated SHARED phosphorylationtinterceding-token ngrams: HepG2t1e2: args2Role-mention-ngram: CONTROLLER abrogatedt2interceding-token ngrams: high baseline expressiontZe2: trigger-arg-path: abrogated >dobj [lemma='phosphorylation'] controlled:Phosphorylationtie1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] controlled:PhosphorylationtOe2: trigger-arg-path: abrogated:Negative_regulation >nsubj Gene_or_gene_producttXe1: trigger-arg-path: induced >dobj [lemma='phosphorylation'] controlled:Phosphorylationtte2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj [lemma='salirasib'] Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtGe1: trigger-arg-path: induced:Positive_regulation >nsubj >nn controllertYe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn controller:Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=abrogate >dobj Phosphorylationt%interceding-token ngrams: but did nott~e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controller:Gene_or_gene_productt0e2: trigger-arg-path: abrogated >dobj controlledt&interceding-token ngrams: already hightke2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj controller:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtce2: trigger-arg-path: abrogated:Negative_regulation >nsubj [lemma='salirasib'] Gene_or_gene_producttHe1: trigger-arg-path: induced >dobj [lemma='phosphorylation'] controlledt%interceding-token ngrams: not furthert,interceding-token ngrams: Huh7 . Importantlytre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt^e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='phosphorylation'] Phosphorylationt&interceding-token ngrams: levels abovet0e1: args2Role-mention-ngram: stimulation inducedt?e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controller:Gene_or_gene_productt interceding-token ngrams: Huh7 .tde1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controllertCe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT abrogated SHAREDt#interceding-token ngrams: and Hep3Bt=e1: trigger-arg-path: induced >nsubj >nn Gene_or_gene_productt*interceding-token ngrams: the already hightme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >dobj [lemma='phosphorylation'] controlledtne2: trigger-arg-path: abrogated:Negative_regulation >nsubj [lemma='salirasib'] controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj Gene_or_gene_productt1e2: args2Role-mention-ngram: abrogated CONTROLLEDtke2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='salirasib'] controller:Gene_or_gene_producttOe2: trigger-arg-path: Negative_regulation >nsubj [lemma='salirasib'] controllert/interceding-token ngrams: already high baselinetVe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='salirasib'] controllert*interceding-token ngrams: further increasetNe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >nn Gene_or_gene_productt^e2: trigger-arg-path: abrogated:Negative_regulation >dobj [lemma='phosphorylation'] controlledt#interceding-token ngrams: HepG2 andtme1: trigger-arg-path: induced >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controller:Gene_or_gene_productt#interceding-token ngrams: in Huh7 .tTe2: trigger-arg-path: abrogated:Negative_regulation >dobj controlled:Phosphorylationt'e2: ents2Label-mention-ngram: abrogatedtDe2: trigger-arg-path: abrogated:Negative_regulation >dobj controlledt&e2: args2Role-mention-ngram: abrogatedtEe2: trigger-arg-path: abrogated >nsubj [lemma='salirasib'] controllert5e2: trigger-arg-path: abrogated >dobj Phosphorylationte2: trigger: abrogatedt1e2: trigger-arg-path: abrogated >nsubj controllert*interceding-token ngrams: levels above thet@e2: trigger-arg-path: abrogated >dobj controlled:Phosphorylationtle1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='stimulation'] >nn [lemma='igf2'] controllert%interceding-token ngrams: Hep3B cellstHe1: trigger-arg-path: induced >nsubj >nn controller:Gene_or_gene_producttFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation inducedt\e1: trigger-arg-path: induced:Positive_regulation >dobj [lemma='phosphorylation'] controlledt"interceding-token ngrams: baselinet,interceding-token ngrams: expression in Huh7tne2: trigger-arg-path: abrogated:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt!interceding-token ngrams: alreadyt;e1: args2Role-mention-ngram: stimulation induced CONTROLLEDtBe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj controllert6interceding-token ngrams: further increase phospho-p70t!interceding-token ngrams: but didtOe2: trigger-arg-path: abrogated >dobj [lemma='phosphorylation'] Phosphorylationtse1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='stimulation'] >nn [lemma='igf2'] Gene_or_gene_productt0interceding-token ngrams: baseline expression intYe2: trigger-arg-path: Negative_regulation >nsubj [lemma='salirasib'] Gene_or_gene_productt2interceding-token ngrams: phospho-p70 levels abovetVe2: trigger-arg-path: lemmatizedTrigger=abrogate:Negative_regulation >nsubj controllert+e1: ents2Label-mention-ngram: MEK1 and Raf1t interceding-token ngrams: and attde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf1'] controlledtne2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pak'] controllert'e1: ents2Label-mention-ngram: at Ser298t"interceding-token ngrams: Ser338 ,t?e2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pak'] controller:Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: MEK1 andtee2: trigger-arg-path: Positive_activation nsubj [lemma='pak'] controllert+e1: ents2Label-mention-ngram: two mediatorst?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pak'] controller:Gene_or_gene_productt1interceding-token ngrams: - While phosphorylationt)e1: ents2Label-mention-ngram: , at Ser298t0e1: ents2Label-mention-ngram: phosphorylates twot?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pak'] controllert?e2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pak'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation >dobj [lemma='raf1'] controlled:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED phosphorylates twot$e1: ents2Label-mention-ngram: Raf1 ,t.e1: ents2Label-mention-ngram: kinase pathway ,tDe1: trigger-arg-path: phosphorylates >nsubj [lemma='pak'] controllertRe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf1'] controlledtde2: trigger-arg-path: activate nsubj [lemma='pak'] Gene_or_gene_productt+e2: args2Role-mention-ngram: not sufficienttze2: trigger-arg-path: Positive_activation nsubj [lemma='pak'] controller:Gene_or_gene_producttNe1: trigger-arg-path: phosphorylates >nsubj [lemma='pak'] Gene_or_gene_producttoe2: trigger-arg-path: activate nsubj [lemma='pak'] controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: not sufficientt.e2: args2Role-mention-ngram: is not sufficienttSe2: trigger-arg-path: activate >dobj [lemma='raf1'] controlled:Gene_or_gene_productt*e1: ents2Label-mention-ngram: mediators oft*interceding-token ngrams: , respectively .tie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak'] controllertinterceding-token ngrams: . ,tee2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf1'] controlled:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf1'] controlled:Gene_or_gene_productt'interceding-token ngrams: and at Ser338t"e1: ents2Label-mention-ngram: , att~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak'] controller:Gene_or_gene_productt(interceding-token ngrams: , respectivelyt(interceding-token ngrams: respectively .tSe2: trigger-arg-path: Positive_activation >dobj [lemma='raf1'] Gene_or_gene_productt2interceding-token ngrams: phosphorylation of thesetSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: to activate GENE_OR_GENE_PRODUCTt"e1: ents2Label-mention-ngram: MEK1t(e1: ents2Label-mention-ngram: , MEK1 andt interceding-token ngrams: Ser338t/e2: ents2Label-mention-ngram: is not sufficienttme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pak'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: pathway ,tYe1: trigger-arg-path: phosphorylates >nsubj [lemma='pak'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pak'] controller:Gene_or_gene_producttbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: kinase pathwaytZe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf1'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: mediators of thet!e1: ents2Label-mention-ngram: twot(e1: ents2Label-mention-ngram: and Raf1 ,tXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak'] controllertge2: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf1'] controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: two mediators oftIe2: trigger-arg-path: Positive_activation >dobj [lemma='raf1'] controlledtle2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pak'] controllert.e2: args2Role-mention-ngram: CONTROLLER is nottHe2: trigger-arg-path: activate >dobj [lemma='raf1'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: Raf1t$CSSPATH: ROOT  ++ ROOT >advcl >xcomptinterceding-token ngrams: . , -t*e2: args2Role-mention-ngram: CONTROLLER ist"interceding-token ngrams: sites byt%interceding-token ngrams: at Ser338 ,tIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak'] controllert+e2: ents2Label-mention-ngram: SHARED is nottne2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pak'] controllert$e1: ents2Label-mention-ngram: , MEK1t'e1: ents2Label-mention-ngram: Raf1 , att>e2: trigger-arg-path: activate >dobj [lemma='raf1'] controlledtse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak'] Gene_or_gene_productt/interceding-token ngrams: While phosphorylationt.e2: args2Role-mention-ngram: not sufficient tot'e1: ents2Label-mention-ngram: mediatorst!interceding-token ngrams: - Whilet/interceding-token ngrams: Ser338 , respectivelytAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinase pathwayt\e2: trigger-arg-path: activate:Positive_activation >dobj [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='pak'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='pak'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: pathway , MEK1t&interceding-token ngrams: respectivelyt=e1: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCT kinaset$e1: ents2Label-mention-ngram: Ser298t;e2: ents2Label-mention-ngram: activate GENE_OR_GENE_PRODUCTt&e1: ents2Label-mention-ngram: and Raf1t2interceding-token ngrams: While phosphorylation oft#interceding-token ngrams: , - Whilet:e1: ents2Label-mention-ngram: phosphorylates two mediatorstPe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf1'] controlledtZe2: trigger-arg-path: activate nsubj [lemma='pak'] controllert*interceding-token ngrams: respectively . ,thinterceding-tokens-full-span: and at Ser338 , respectively . , - While phosphorylation of these sites byt(interceding-token ngrams: these sites byt#interceding-token ngrams: at Ser338t/e2: ents2Label-mention-ngram: not sufficient totoe2: trigger-arg-path: Positive_activation nsubj [lemma='pak'] Gene_or_gene_producttxe2: trigger-arg-path: activate:Positive_activation nsubj [lemma='pak'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: dose of 100tme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='bbr'] Gene_or_gene_productt%e2: args2Role-mention-ngram: markedlyt(e2: ents2Label-mention-ngram: 100 microMtOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p65'] themet+e2: ents2Label-mention-ngram: NF-kappaB p50tTe2: trigger-arg-path: inhibited >nsubj [lemma='bbr'] controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: the doset'e2: args2Role-mention-ngram: 100 microMtIe1: trigger-arg-path: Binding prep_to >nn Gene_or_gene_productt$e2: ents2Label-mention-ngram: microMt/e2: ents2Label-mention-ngram: NF-kappaB p50 andtGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p65'] themete1: trigger-arg-path: binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] Gene_or_gene_producttSe2: trigger-arg-path: Negative_regulation >nsubj [lemma='bbr'] Gene_or_gene_productt:e2: ents2Label-mention-ngram: markedly inhibited NF-kappaBt*e2: args2Role-mention-ngram: of 100 microMtQe1: trigger-arg-path: binding:Binding prep_to >nn Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='bbr'] controllert!e2: args2Role-mention-ngram: dosethe1: trigger-arg-path: binding prep_to [lemma='probe'] >nn [lemma='cox-2'] themet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p65'] Gene_or_gene_producttdtrigger-to-trigger-path: e1:binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] Gene_or_gene_productt5e1: trigger-arg-path: binding >nn [lemma='p65'] themet&e2: ents2Label-mention-ngram: markedlyt=e1: trigger-arg-path: binding:Binding >nn [lemma='p65'] themet\e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p65'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: dose of 100tTe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn themet)e2: ents2Label-mention-ngram: the dose oft4e2: args2Role-mention-ngram: inhibited NF-kappaB p50txe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='bbr'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: p50 and CONTROLLEDtie1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn theme:Gene_or_gene_producttLe1: trigger-arg-path: binding:Binding >nn [lemma='p65'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: the doset1e2: ents2Label-mention-ngram: 100 microM markedlytpe1: trigger-arg-path: binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] themet$e2: ents2Label-mention-ngram: of 100tRtrigger-to-trigger-path: e1:binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: dose oft:e1: trigger-arg-path: binding prep_to >nn themetOe1: trigger-arg-path: Binding prep_to >nn theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: microMt]e2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='bbr'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: p50t+e2: ents2Label-mention-ngram: of 100 microMtRe1: trigger-arg-path: binding:Binding >nn [lemma='p65'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] controller:Gene_or_gene_producttSe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='bbr'] controllert}e1: trigger-arg-path: Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttIe2: trigger-arg-path: inhibited >nsubj [lemma='bbr'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn Gene_or_gene_producttBe1: trigger-arg-path: binding:Binding prep_to >nn themet}e1: trigger-arg-path: binding prep_to [lemma='probe'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding prep_to >nn themet0e2: ents2Label-mention-ngram: markedly inhibitedt(e2: args2Role-mention-ngram: the dose oft^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p65'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: 100t)e2: ents2Label-mention-ngram: at the dosetJe1: trigger-arg-path: binding >nn [lemma='p65'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn themet%e2: ents2Label-mention-ngram: p50 andtIe2: trigger-arg-path: Negative_regulation >nsubj [lemma='bbr'] controllert/e2: args2Role-mention-ngram: markedly inhibitedt5e2: ents2Label-mention-ngram: inhibited NF-kappaB p50t,e2: ents2Label-mention-ngram: p50 and SHAREDtQshortest-path: nsubj [lemma='bbr']t9e2: args2Role-mention-ngram: markedly inhibited NF-kappaBtae1: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] controllert1e2: ents2Label-mention-ngram: inhibited NF-kappaBt^e2: trigger-arg-path: Negative_regulation >nsubj [lemma='bbr'] controller:Gene_or_gene_producttOe1: trigger-arg-path: binding prep_to >nn theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: doset0e2: args2Role-mention-ngram: 100 microM markedlyt-e2: ents2Label-mention-ngram: microM markedlyt#e2: args2Role-mention-ngram: of 100tWe1: trigger-arg-path: binding:Binding prep_to >nn theme:Gene_or_gene_productt6e2: args2Role-mention-ngram: microM markedly inhibitedt?e2: trigger-arg-path: inhibited >nsubj [lemma='bbr'] controllert?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] themet$e2: args2Role-mention-ngram: dose oft$e2: args2Role-mention-ngram: p50 andt e2: args2Role-mention-ngram: p50t.e2: args2Role-mention-ngram: NF-kappaB p50 andthe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='bbr'] controller:Gene_or_gene_producttwe1: trigger-arg-path: Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] Gene_or_gene_productt?e1: trigger-arg-path: binding:Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttDe1: trigger-arg-path: binding >nn [lemma='p65'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: microM markedly inhibitedtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p65'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='probe'] >nn [lemma='cox-2'] themet9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT at thet(e2: args2Role-mention-ngram: at the dosetwe1: trigger-arg-path: binding prep_to [lemma='probe'] >nn [lemma='cox-2'] Gene_or_gene_producttshortest-path: nsubjthe1: trigger-arg-path: Binding prep_to [lemma='probe'] >nn [lemma='cox-2'] themetYe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='bbr'] Gene_or_gene_productt e2: args2Role-mention-ngram: 100t*e2: args2Role-mention-ngram: NF-kappaB p50t0e2: args2Role-mention-ngram: inhibited NF-kappaBt,e2: args2Role-mention-ngram: microM markedlyt?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='probe'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttIe1: trigger-arg-path: binding prep_to >nn Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='mdm2'] themet+e2: ents2Label-mention-ngram: mutant SHAREDt6e2: ents2Label-mention-ngram: theoretically might helpt'e2: args2Role-mention-ngram: might helptme2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj >nn controlled:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mdm2'] Gene_or_gene_producttAe2: trigger-arg-path: reverse nsubj >nn controller:FamilytSe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj >nn controller:Familyt1interceding-token ngrams: allowing ubiquitinationtNe2: trigger-arg-path: lemmatizedTrigger=reverse >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controllertde1: trigger-arg-path: Binding >nsubj >prep_of >prep_with >vmod >prep_from theme:Gene_or_gene_productthe2: trigger-arg-path: reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlledtge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mdm2'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] controlled:Gene_or_gene_producttUe1: trigger-arg-path: bound:Binding >nsubj >prep_of >prep_with >vmod >prep_from themetHe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj >nn FamilytNe1: trigger-arg-path: bound >prep_to [lemma='mdm2'] theme:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >prep_with >vmod >prep_from Gene_or_gene_productt)e2: args2Role-mention-ngram: help reverset:e2: trigger-arg-path: reverse nsubj >nn controllertze2: trigger-arg-path: Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controllert@e2: args2Role-mention-ngram: CONTROLLER inhibition theoreticallyt5e2: args2Role-mention-ngram: theoretically might helpt\e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj >nn Familyt0e2: ents2Label-mention-ngram: reverse the mutantt?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controller:Familyt/e2: ents2Label-mention-ngram: the mutant SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: FAMILY inhibition theoreticallytue2: trigger-arg-path: reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controller:Familyt*e2: args2Role-mention-ngram: theoreticallytve2: trigger-arg-path: Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] Familyt?e2: trigger-arg-path: reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controllert)e2: ents2Label-mention-ngram: reverse thetie2: trigger-arg-path: reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] Gene_or_gene_productt/e2: args2Role-mention-ngram: reverse the mutanttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >prep_with >vmod >prep_from themetHe1: trigger-arg-path: bound >prep_to [lemma='mdm2'] Gene_or_gene_producttVe1: trigger-arg-path: bound:Binding >prep_to [lemma='mdm2'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Positive_activation nsubj >nn controllert?e2: trigger-arg-path: reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controller:FamilytTe2: trigger-arg-path: reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] controlledtbe1: trigger-arg-path: bound >nsubj >prep_of >prep_with >vmod >prep_from theme:Gene_or_gene_producttPe1: trigger-arg-path: bound:Binding >prep_to [lemma='mdm2'] Gene_or_gene_producttJe2: trigger-arg-path: reverse:Positive_activation nsubj >nn Familyt%e2: ents2Label-mention-ngram: reversetze2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlledt|e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] themet(e2: args2Role-mention-ngram: reverse thet?e1: trigger-arg-path: bound >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] themet`e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj >nn controllert6e2: ents2Label-mention-ngram: inhibition theoreticallytLinterceding-tokens-full-span: allowing ubiquitination and degradation . ThustUe2: trigger-arg-path: reverse:Positive_activation nsubj >nn controller:Familyt'e2: args2Role-mention-ngram: the mutantt5interceding-token ngrams: allowing ubiquitination andt?e1: trigger-arg-path: Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] Gene_or_gene_productt[e2: trigger-arg-path: reverse:Positive_activation >dobj >nn controlled:Gene_or_gene_productt}e2: trigger-arg-path: reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: bound >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] Gene_or_gene_productt.e2: args2Role-mention-ngram: mutant CONTROLLEDtje2: trigger-arg-path: Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] Gene_or_gene_producttPe2: trigger-arg-path: reverse:Positive_activation >dobj >nn Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >prep_with >vmod >prep_from themet?e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] Familyt;e2: args2Role-mention-ngram: inhibition theoretically mightt{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj >prep_of >prep_with >vmod >prep_from theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: theoreticallytme1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >prep_with >vmod >prep_from Gene_or_gene_productt1e2: ents2Label-mention-ngram: theoretically mightt^e1: trigger-arg-path: Binding >nsubj >prep_of >prep_with >vmod >prep_from Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controller:Familytse1: trigger-arg-path: lemmatizedTrigger=bind >nsubj >prep_of >prep_with >vmod >prep_from theme:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] controlledtje1: trigger-arg-path: bound:Binding >nsubj >prep_of >prep_with >vmod >prep_from theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mdm2'] themet(e2: ents2Label-mention-ngram: the mutantt!e2: args2Role-mention-ngram: helptMe2: trigger-arg-path: Positive_activation nsubj >nn controller:Familyt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mdm2'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='mdm2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=reverse nsubj >nn controllert,interceding-token ngrams: degradation . Thust?e1: trigger-arg-path: Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] themet2e2: args2Role-mention-ngram: the mutant CONTROLLEDtGe2: trigger-arg-path: reverse >dobj >nn controlled:Gene_or_gene_productt5e2: args2Role-mention-ngram: inhibition theoreticallytre2: trigger-arg-path: reverse:Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] Gene_or_gene_producttprep_to [lemma='mdm2'] themet?e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controllerte2: trigger: reversetXe2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj >nn controlledt.e2: ents2Label-mention-ngram: help reverse thet$e2: args2Role-mention-ngram: reversetNe2: trigger-arg-path: reverse:Positive_activation nsubj >nn controllertdobj >nn Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj >prep_of >prep_with >vmod >prep_from themetMe1: trigger-arg-path: bound >nsubj >prep_of >prep_with >vmod >prep_from themet?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controller:Familyt`e2: trigger-arg-path: Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlledtue2: trigger-arg-path: Positive_activation >dobj [lemma='phenotype'] >nn [lemma='p53'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: bound >nsubj >prep_of >prep_with >vmod >prep_from Gene_or_gene_productt6e2: trigger-arg-path: reverse nsubj >nn FamilytAe1: trigger-arg-path: bound:Binding >prep_to [lemma='mdm2'] themetde1: trigger-arg-path: bound:Binding >nsubj >prep_of >prep_with >vmod >prep_from Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] theme:Gene_or_gene_productt?e1: trigger-arg-path: bound >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mdm2'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=reverse:Positive_activation nsubj >nn controller:Familytje2: trigger-arg-path: reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] Familyt?e1: trigger-arg-path: Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: helpt0e2: args2Role-mention-ngram: theoretically mighttJe1: trigger-arg-path: Binding >prep_to [lemma='mdm2'] Gene_or_gene_productt9e1: trigger-arg-path: bound >prep_to [lemma='mdm2'] themet?e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] themetne2: trigger-arg-path: reverse nsubj [lemma='inhibition'] >nn [lemma='hsp90'] controllert0e2: ents2Label-mention-ngram: might help reverset?e1: trigger-arg-path: bound:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] theme:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] Gene_or_gene_productt-e2: args2Role-mention-ngram: help reverse thetBe2: trigger-arg-path: Positive_activation nsubj >nn FamilytDe2: trigger-arg-path: lemmatizedTrigger=reverse >dobj >nn controlledt(e2: ents2Label-mention-ngram: might helpt*e2: ents2Label-mention-ngram: help reversetYe2: trigger-arg-path: lemmatizedTrigger=reverse >dobj >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: bound:Binding >nsubj [lemma='knock-down'] >prep_of [lemma='inhibition'] >prep_with [lemma='17-aag'] >vmod [lemma='result'] >prep_from [lemma='p53'] themet^e2: trigger-arg-path: reverse >dobj [lemma='phenotype'] >nn [lemma='p53'] Gene_or_gene_productt~e2: trigger-arg-path: reverse:Positive_activation nsubj [lemma='inhibition'] >nn [lemma='hsp90'] Familyt/e2: args2Role-mention-ngram: might help reverset2e2: trigger-arg-path: reverse >dobj >nn controlledtFe2: trigger-arg-path: reverse:Positive_activation >dobj >nn controlledtRe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ra'] controllert%interceding-token ngrams: . Oncogenictwe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >prep_of [lemma='htra2'] Gene_or_gene_productt8e1: trigger-arg-path: induces >nsubj [lemma='ra'] FamilytCe1: trigger-arg-path: induces >nsubj [lemma='ra'] controller:Familyt_e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] Familyt-e2: trigger-arg-path: increased >nsubj Familyt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] Gene_or_gene_productt>e2: trigger-arg-path: increased >nsubj [lemma='ra'] controllert>e2: ents2Label-mention-ngram: SHARED increased phosphorylationtLe2: trigger-arg-path: increased:Positive_regulation >nsubj controller:Familytre1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] controllerthe1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlledt(e2: ents2Label-mention-ngram: at Ser 142t(e2: ents2Label-mention-ngram: Omi at Sertinterceding-token ngrams: a p53tOe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] controllertRe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj Familyt!e2: ents2Label-mention-ngram: 142t+e1: trigger-arg-path: induces >nsubj Familyt(e2: ents2Label-mention-ngram: and Omi att}e1: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlled:Gene_or_gene_producttze1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] Gene_or_gene_productt8e2: trigger-arg-path: increased >nsubj controller:FamilytJe1: trigger-arg-path: induces:Positive_activation >nsubj controller:Familyt3e1: args2Role-mention-ngram: induces the activationt)interceding-token ngrams: a p53 dependentt3e1: args2Role-mention-ngram: CONTROLLER induces thetje2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] controller:Familyt$e2: ents2Label-mention-ngram: Omi attWe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='ra'] controller:Familyt"interceding-token ngrams: Omi in at4e1: ents2Label-mention-ngram: induces the activationtnsubj [lemma='ra'] controllertPe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='ra'] controllertpe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlledtVe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] controller:Familytfe1: trigger-arg-path: induces >dobj [lemma='activation'] >prep_of [lemma='htra2'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj Familyt0e1: ents2Label-mention-ngram: SHARED induces thet?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlledt%e2: ents2Label-mention-ngram: Ser 142t!e2: ents2Label-mention-ngram: Sert?e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlled:Gene_or_gene_productt:e2: trigger-arg-path: increased >nsubj [lemma='ra'] Familyt$e2: ents2Label-mention-ngram: at SertEe2: trigger-arg-path: increased >nsubj [lemma='ra'] controller:Familyt.interceding-token ngrams: p53 dependent mannert,interceding-token ngrams: manner . OncogenictKe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='ra'] Familyt.e2: ents2Label-mention-ngram: SHARED increasedt[e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj controller:Familyt?e1: trigger-arg-path: induces:Positive_activation >nsubj FamilytYe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ra'] controller:Familyt]e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj controller:Familyt"interceding-token ngrams: in a p53t6e1: trigger-arg-path: induces >nsubj controller:FamilytNe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='ra'] Familyt\e1: trigger-arg-path: induces >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlled:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] controller:FamilytIe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj controller:Familyt>e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj Familyt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='ra'] FamilytAe2: trigger-arg-path: increased:Positive_regulation >nsubj Familytce2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='ra'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlledtLe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='ra'] Familytqe1: trigger-arg-path: induces >dobj [lemma='activation'] >prep_of [lemma='htra2'] controlled:Gene_or_gene_producttKinterceding-tokens-full-span: and Omi in a p53 dependent manner . Oncogenict#interceding-token ngrams: OncogenictHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] themetMe2: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='cdc2'] themetIe2: trigger-arg-path: complex >nn [lemma='cyclinb1'] Gene_or_gene_productt6e1: trigger-arg-path: complex >nn [lemma='cdc2'] themetWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] Gene_or_gene_producttWe2: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] Gene_or_gene_producttEe1: trigger-arg-path: Binding >nn [lemma='cdc2'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] themetie1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nn [lemma='cyclinb1'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] themetLe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] themetTe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] themet:e1: trigger-arg-path: Binding >nn [lemma='cyclinb1'] themetKe1: trigger-arg-path: complex >nn [lemma='cdc2'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='cdc2'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] Gene_or_gene_productt:e1: trigger-arg-path: complex >nn [lemma='cyclinb1'] themetIe1: trigger-arg-path: complex >nn [lemma='cyclinb1'] Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] theme:Gene_or_gene_producttOe1: trigger-arg-path: complex >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='cdc2'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='cdc2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] themetKe1: trigger-arg-path: Binding >nn [lemma='cdc2'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cyclinb1'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] themetWe1: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttBe2: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] themetOe2: trigger-arg-path: complex >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] theme:Gene_or_gene_producttQe2: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='cdc2'] theme:Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] themetEe2: trigger-arg-path: Binding >nn [lemma='cdc2'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] themet6e1: trigger-arg-path: Binding >nn [lemma='cdc2'] themet:e2: trigger-arg-path: Binding >nn [lemma='cyclinb1'] themetBe1: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] themet:e2: trigger-arg-path: complex >nn [lemma='cyclinb1'] themetEe1: trigger-arg-path: complex >nn [lemma='cdc2'] Gene_or_gene_producttQe1: trigger-arg-path: complex:Binding >nn [lemma='cyclinb1'] Gene_or_gene_producttSe1: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >nn [lemma='cyclinb1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc2'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cyclinb1'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='cdc2'] themet_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc2'] Gene_or_gene_producttFe2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc1'] themetLe2: trigger-arg-path: Binding >prep_with [lemma='tsc1'] Gene_or_gene_producttUe2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc1'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tsc1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: interact >prep_with [lemma='tsc1'] theme:Gene_or_gene_productt>e2: trigger-arg-path: interact >prep_with [lemma='tsc1'] themetMe2: trigger-arg-path: interact >prep_with [lemma='tsc1'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc1'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_with [lemma='tsc1'] themetge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tsc1'] Gene_or_gene_productt[e2: trigger-arg-path: interact:Binding >prep_with [lemma='tsc1'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc1'] themet_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tsc1'] Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='tsc1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tsc1'] themet?e1: trigger-arg-path: increased:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlled:Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='cav1'] themetFe2: trigger-arg-path: interacted >prep_with theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: THEME interacted withtTe1: trigger-arg-path: increased:Positive_activation >ccomp >dobj >prep_of controlledt6e1: args2Role-mention-ngram: starvation induced levelstJe2: trigger-arg-path: interacted:Binding >nsubj theme:Gene_or_gene_productt-e2: trigger-arg-path: interacted >nsubj themet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] Gene_or_gene_producttTe1: trigger-arg-path: Positive_activation >ccomp >dobj >prep_of Gene_or_gene_producttle1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controllert5e1: trigger-arg-path: increased >nsubj >nn controllert9e2: trigger-arg-path: interacted:Binding >prep_with themetZe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn controllert,e1: args2Role-mention-ngram: increased basaltfe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp >dobj >prep_of controlled:Gene_or_gene_producttHe2: trigger-arg-path: interacted:Binding >prep_with [lemma='atg5'] themet)interceding-token ngrams: and autophagy .tle1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] Gene_or_gene_productt?e1: trigger-arg-path: increased >nsubj >nn Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: depletion increased basaltPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atg5'] themet?e1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atg5'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg5'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: induced levels oftbe1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controllertSe2: trigger-arg-path: interacted:Binding >nsubj [lemma='cav1'] Gene_or_gene_productt?e1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: depletion increasedt~e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >nn [lemma='cav1'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='cav1'] Gene_or_gene_producttnsubj Gene_or_gene_producttXe1: trigger-arg-path: increased >nsubj [lemma='depletion'] >nn [lemma='cav1'] controllertBe2: trigger-arg-path: interacted >nsubj theme:Gene_or_gene_productt1interceding-token ngrams: autophagy . Biochemicalt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlled:Gene_or_gene_producttie1: trigger-arg-path: increased:Positive_activation >ccomp >dobj >prep_of controlled:Gene_or_gene_productt+e1: args2Role-mention-ngram: and starvationtme1: trigger-arg-path: increased >nsubj [lemma='depletion'] >nn [lemma='cav1'] controller:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_with [lemma='atg5'] themet/e1: args2Role-mention-ngram: starvation inducedtDe2: trigger-arg-path: interacted:Binding >nsubj Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='cav1'] theme:Gene_or_gene_productt5e2: trigger-arg-path: interacted:Binding >nsubj themetSe1: trigger-arg-path: increased:Positive_activation >nsubj >nn Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] Gene_or_gene_productt@e2: trigger-arg-path: interacted >prep_with [lemma='atg5'] themet8e1: ents2Label-mention-ngram: SHARED depletion increasedt?e1: trigger-arg-path: increased >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlled:Gene_or_gene_productt6e1: args2Role-mention-ngram: depletion increased basalt?e1: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlledtee1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp >dobj >prep_of controlledt-e1: ents2Label-mention-ngram: increased basalt(e2: ents2Label-mention-ngram: interactedtve1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] Gene_or_gene_producttwe1: trigger-arg-path: Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controller:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controllert[e1: trigger-arg-path: lemmatizedTrigger=increase >ccomp >dobj >prep_of Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg5'] themet-e2: args2Role-mention-ngram: THEME interactedtNe2: trigger-arg-path: interacted:Binding >prep_with theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: interactedt4e2: ents2Label-mention-ngram: SHARED interacted witht^e1: trigger-arg-path: increased:Positive_activation >ccomp >dobj >prep_of Gene_or_gene_productt'e1: args2Role-mention-ngram: starvationtHe2: trigger-arg-path: interacted:Binding >prep_with Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >nn [lemma='cav1'] controllertve1: trigger-arg-path: increased >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlledtae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='cav1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlled:Gene_or_gene_productt0e1: ents2Label-mention-ngram: starvation inducedt@e1: trigger-arg-path: increased >ccomp >dobj >prep_of controlledt2e2: args2Role-mention-ngram: interacted with THEMEtLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='cav1'] themet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] controller:Gene_or_gene_productt%interceding-token ngrams: autophagy .tee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='atg5'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='atg5'] Gene_or_gene_producttKe2: trigger-arg-path: interacted >nsubj [lemma='cav1'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: starvationt+e1: args2Role-mention-ngram: induced levelst7e1: ents2Label-mention-ngram: starvation induced levelst?e1: trigger-arg-path: increased:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlledte2: trigger: interactedtbe1: trigger-arg-path: increased >nsubj [lemma='depletion'] >nn [lemma='cav1'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: increased basal andt]e2: trigger-arg-path: interacted:Binding >prep_with [lemma='atg5'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='depletion'] >nn [lemma='cav1'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp >dobj >prep_of controlled:Gene_or_gene_producttQe2: trigger-arg-path: interacted >nsubj [lemma='cav1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: increased >ccomp >dobj >prep_of Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='cav1'] theme:Gene_or_gene_producttnsubj [lemma='cav1'] themet?e1: trigger-arg-path: increased:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] Gene_or_gene_producttYe2: trigger-arg-path: interacted:Binding >nsubj [lemma='cav1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn controller:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_with [lemma='atg5'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: and starvationt2e1: ents2Label-mention-ngram: basal and starvationtQe1: trigger-arg-path: lemmatizedTrigger=increase >ccomp >dobj >prep_of controlledt[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='cav1'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: SHARED depletiontPe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn Gene_or_gene_producttDe2: trigger-arg-path: interacted:Binding >nsubj [lemma='cav1'] themet-e2: ents2Label-mention-ngram: interacted witht^e1: trigger-arg-path: increased:Positive_activation >nsubj >nn controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: interacted with SHAREDt?e1: trigger-arg-path: increased >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] Gene_or_gene_productt3e1: args2Role-mention-ngram: and starvation inducedtTe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='cav1'] themet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='depletion'] >nn [lemma='cav1'] Gene_or_gene_productt.e1: args2Role-mention-ngram: induced levels oft4e1: ents2Label-mention-ngram: and starvation inducedtoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >ccomp >dobj >prep_of Gene_or_gene_productt1e2: trigger-arg-path: interacted >prep_with themetWe2: trigger-arg-path: interacted:Binding >prep_with [lemma='atg5'] Gene_or_gene_productt@e2: trigger-arg-path: interacted >prep_with Gene_or_gene_producttUe1: trigger-arg-path: increased >ccomp >dobj >prep_of controlled:Gene_or_gene_producttPinterceding-tokens-full-span: and autophagy . Biochemical analysis revealed thatt?e1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlledtJe1: trigger-arg-path: Positive_activation >ccomp >dobj >prep_of controlledtOe2: trigger-arg-path: interacted >prep_with [lemma='atg5'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: depletion increasedtFe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn controllert/e2: ents2Label-mention-ngram: SHARED interactedtUe2: trigger-arg-path: interacted >prep_with [lemma='atg5'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: interacted withtHe2: trigger-arg-path: Binding >nsubj [lemma='cav1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: basal and starvationt_e1: trigger-arg-path: Positive_activation >ccomp >dobj >prep_of controlled:Gene_or_gene_productt;e1: args2Role-mention-ngram: CONTROLLER depletion increasedtde1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='atg5'] Gene_or_gene_producttJe1: trigger-arg-path: increased >nsubj >nn controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: induced levelst'interceding-token ngrams: and autophagyt?e1: trigger-arg-path: lemmatizedTrigger=increase >ccomp [lemma='induce'] >dobj [lemma='level'] >prep_of [lemma='atg12-atg5'] controlled:Gene_or_gene_productt0e1: args2Role-mention-ngram: increased basal andtIe1: trigger-arg-path: increased:Positive_activation >nsubj >nn controllertYe2: trigger-arg-path: promoted:Positive_regulation >nsubj controller:Gene_or_gene_productt/interceding-token ngrams: Pin1 dependent mannert\e2: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt1e2: ents2Label-mention-ngram: poly-ubiquitinationtZe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn controller:Gene_or_gene_producttke1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtce1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn Gene_or_gene_productt.interceding-token ngrams: drastically reversedt7e1: args2Role-mention-ngram: kinase promotes CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: kinase promotes SHAREDtye1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt0e2: trigger-arg-path: promoted >nsubj controllert4e1: trigger-arg-path: promotes >nsubj >nn controllertge2: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: kinase promotestOe1: trigger-arg-path: lemmatizedTrigger=promote >dobj controlled:Ubiquitinationtce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] controllert,interceding-token ngrams: Indeed , depletiontLe1: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] Ubiquitinationtne1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttqe1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt(interceding-token ngrams: Pin1 dependentt"interceding-token ngrams: by siRNAt-e2: ents2Label-mention-ngram: SHARED promotedtIe1: trigger-arg-path: promotes >nsubj >nn controller:Gene_or_gene_productthe1: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn controllertTe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj controlledtxe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttinterceding-token ngrams: siRNAtnsubj [lemma='erk'] controllert3e1: trigger-arg-path: promotes >dobj Ubiquitinationtxe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert]e1: trigger-arg-path: promotes:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttHe2: trigger-arg-path: promoted >nsubj [lemma='erk'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj controller:Gene_or_gene_productt2interceding-token ngrams: drastically reversed thet@e1: trigger-arg-path: lemmatizedTrigger=promote >dobj controlledt\e1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] controlledtEe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn controllertme2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt'interceding-token ngrams: Pin1 by siRNAt!interceding-token ngrams: Pin1 bytYe1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] controlledt]e1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] Ubiquitinationt)interceding-token ngrams: manner . Indeedt4interceding-token ngrams: siRNA drastically reversedt#interceding-token ngrams: in a Pin1t;e2: ents2Label-mention-ngram: poly-ubiquitination of SHAREDtSe1: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertqe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt:e2: trigger-arg-path: promoted >nsubj Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >nn Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] Gene_or_gene_productt>e1: trigger-arg-path: promotes >dobj controlled:UbiquitinationtWe1: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt/e1: trigger-arg-path: promotes >dobj controlledtXe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj Ubiquitinationt interceding-token ngrams: a Pin1t)interceding-token ngrams: endogenous Pin1t4e2: ents2Label-mention-ngram: poly-ubiquitination oft`e1: trigger-arg-path: promotes:Positive_regulation >dobj [lemma='ubiquitination'] UbiquitinationtHe1: trigger-arg-path: promotes:Positive_regulation >nsubj >nn controllertOe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] controllert+interceding-token ngrams: siRNA drasticallyt%interceding-token ngrams: drasticallyt7e1: args2Role-mention-ngram: CONTROLLER kinase promotestme1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj [lemma='ubiquitination'] controlledt?interceding-tokens-full-span: in a Pin1 dependent manner . Indeed , depletion of endogenous Pin1 by siRNA drastically reversed thet"interceding-token ngrams: reversedtDe1: trigger-arg-path: lemmatizedTrigger=promote >dobj Ubiquitinationt=e2: ents2Label-mention-ngram: promoted poly-ubiquitination oft>e2: trigger-arg-path: promoted >nsubj [lemma='erk'] controllertge1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertCe1: trigger-arg-path: promotes:Positive_regulation >dobj controlledt|e1: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttSe2: trigger-arg-path: promoted >nsubj [lemma='erk'] controller:Gene_or_gene_productt,interceding-token ngrams: of endogenous Pin1t,e1: args2Role-mention-ngram: kinase promotesthe1: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='ubiquitination'] controlled:UbiquitinationtNe2: trigger-arg-path: promoted:Positive_regulation >nsubj Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER promotedt,interceding-token ngrams: endogenous Pin1 byt>e1: trigger-arg-path: promotes >nsubj >nn Gene_or_gene_productt0e2: args2Role-mention-ngram: promoted CONTROLLEDtDe2: trigger-arg-path: promoted:Positive_regulation >nsubj controllertRe1: trigger-arg-path: promotes:Positive_regulation >dobj controlled:Ubiquitinationtde2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj Gene_or_gene_productt]e1: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert*interceding-token ngrams: a Pin1 dependenttAe2: ents2Label-mention-ngram: SHARED promoted poly-ubiquitinationtinterceding-token ngrams: Pin1tGe1: trigger-arg-path: promotes:Positive_regulation >dobj Ubiquitinationt:e2: ents2Label-mention-ngram: promoted poly-ubiquitinationt4e1: ents2Label-mention-ngram: SHARED kinase promotestce1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >dobj controlled:Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt;e2: args2Role-mention-ngram: CONTROLLER promoted CONTROLLEDtHe1: trigger-arg-path: promotes >dobj [lemma='ubiquitination'] controlledt.interceding-token ngrams: by siRNA drasticallytEe2: trigger-arg-path: promoted >nsubj controller:Gene_or_gene_producttRe1: trigger-arg-path: promotes:Positive_regulation >nsubj >nn Gene_or_gene_productt*interceding-token ngrams: with mitomycin Ct/interceding-token ngrams: target gene promoterstTe1: trigger-arg-path: enhance >nsubj [lemma='smad2'] controller:Gene_or_gene_productt!interceding-token ngrams: or witht'interceding-token ngrams: treatment didtve1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: can also enhancet2interceding-token ngrams: not significantly changetSe2: trigger-arg-path: binding prep_to >poss theme:Generic_entitytLe2: trigger-arg-path: binding:Binding prep_to >poss themet/interceding-token ngrams: of autocrine TGF-betat interceding-token ngrams: to itst)interceding-token ngrams: without or witht(interceding-token ngrams: was likely duet)interceding-token ngrams: of p53 activityt=e2: trigger-arg-path: binding:Binding >nn [lemma='p53'] themetge1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='element'] >poss [lemma='its'] Generic_entityt'interceding-token ngrams: , the reducedt,interceding-token ngrams: promoters in DNRIIt[e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='smad2'] Gene_or_gene_producttme1: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt+interceding-token ngrams: gene promoters int8e1: args2Role-mention-ngram: enhance the transcriptionaltde1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlledt9e1: trigger-arg-path: enhance >nsubj Gene_or_gene_productt#interceding-token ngrams: promoterst3e1: args2Role-mention-ngram: activity of CONTROLLEDt'interceding-token ngrams: study , sincet,interceding-token ngrams: TGF-beta signalingt,interceding-token ngrams: RIKI treatment didt?e2: trigger-arg-path: Binding prep_to [lemma='element'] >poss [lemma='its'] themet&interceding-token ngrams: change totalt(interceding-token ngrams: the inhibitiontJe2: trigger-arg-path: binding >nn [lemma='p53'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] themet!interceding-token ngrams: or RIKIt_e2: trigger-arg-path: lemmatizedTrigger=binding prep_to >poss Generic_entitytDe2: trigger-arg-path: Binding prep_to >poss themet$interceding-token ngrams: p53 levelst(interceding-token ngrams: since blockadet?e2: trigger-arg-path: binding:Binding prep_to [lemma='element'] >poss [lemma='its'] Generic_entityt&interceding-token ngrams: In our studyt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='element'] >poss [lemma='its'] Generic_entityt-e1: args2Role-mention-ngram: also enhance thet*interceding-token ngrams: change total p53t(interceding-token ngrams: signaling witht7e2: ents2Label-mention-ngram: binding to GENERIC_ENTITYtje1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj controller:Gene_or_gene_productt'interceding-token ngrams: to its targett*interceding-token ngrams: , since blockadet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='element'] >poss [lemma='its'] theme:Generic_entitytze1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='smad2'] controller:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] themet'interceding-token ngrams: expression ort^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >poss themet0interceding-token ngrams: DNRII expressing cellst+interceding-token ngrams: not significantlytje1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] controlledtDe1: trigger-arg-path: enhance >nsubj controller:Gene_or_gene_productt1interceding-token ngrams: TGF-beta signaling witht;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can alsot+interceding-token ngrams: treatment did nott-interceding-token ngrams: DNRII expression ort?e2: trigger-arg-path: Binding prep_to [lemma='element'] >poss [lemma='its'] Generic_entityt^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] Gene_or_gene_producttCe1: trigger-arg-path: enhance:Positive_activation >nsubj controllert+interceding-token ngrams: levels without ortKe1: trigger-arg-path: enhance:Positive_activation >dobj >prep_of controlledt,interceding-token ngrams: expression or RIKIt%interceding-token ngrams: reduced p53t"interceding-token ngrams: in DNRIIt#interceding-token ngrams: autocrinet)interceding-token ngrams: treatment , thet interceding-token ngrams: or thet-e1: args2Role-mention-ngram: can also enhancet%interceding-token ngrams: our study ,t5e2: trigger-arg-path: binding >nn [lemma='p53'] themet0e1: args2Role-mention-ngram: CONTROLLER can alsot.interceding-token ngrams: significantly changet*e1: ents2Label-mention-ngram: also enhancetAe1: trigger-arg-path: enhance >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding prep_to [lemma='element'] >poss [lemma='its'] themet&interceding-token ngrams: p53 activityt6e1: ents2Label-mention-ngram: transcriptional activityt?e1: trigger-arg-path: enhance >nsubj [lemma='smad2'] controllert(interceding-token ngrams: p53 binding totne1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] Gene_or_gene_productt$interceding-token ngrams: with DNRIIt%interceding-token ngrams: C treatmenttee1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='smad2'] controllertSe2: trigger-arg-path: Binding prep_to >poss theme:Generic_entitytge2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >poss Generic_entityt~e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlledt/interceding-token ngrams: did not significantlyt*interceding-token ngrams: DNRII expressiontVe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >poss themetUe1: trigger-arg-path: enhance:Positive_activation >dobj >prep_of Gene_or_gene_productt9e1: args2Role-mention-ngram: the transcriptional activitytVe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='smad2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='element'] >poss [lemma='its'] theme:Generic_entityt9e1: ents2Label-mention-ngram: transcriptional activity oftme2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >poss theme:Generic_entityt'interceding-token ngrams: likely due totUe1: trigger-arg-path: Positive_activation >nsubj [lemma='smad2'] Gene_or_gene_productt?e2: trigger-arg-path: binding prep_to [lemma='element'] >poss [lemma='its'] Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] Gene_or_gene_productt/interceding-token ngrams: blockade of autocrinet%interceding-token ngrams: p53 bindingtLe1: trigger-arg-path: enhance >dobj >prep_of controlled:Gene_or_gene_productt$interceding-token ngrams: its targettde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: transcriptional activityt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='element'] >poss [lemma='its'] themet8e1: args2Role-mention-ngram: transcriptional activity oftUe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj controllertIe1: trigger-arg-path: enhance >nsubj [lemma='smad2'] Gene_or_gene_producttSe1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='smad2'] controllert&interceding-token ngrams: promoters int#interceding-token ngrams: our studytinterceding-token ngrams: RIKIt1e1: ents2Label-mention-ngram: the transcriptionalt"interceding-token ngrams: TGF-betat?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt-interceding-token ngrams: in DNRII expressingt#interceding-token ngrams: cells wast#interceding-token ngrams: total p53t4interceding-token ngrams: significantly change totalt!interceding-token ngrams: , sincet`e1: trigger-arg-path: Positive_activation >nsubj [lemma='smad2'] controller:Gene_or_gene_productt,interceding-token ngrams: autocrine TGF-betat_e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj Gene_or_gene_producttye1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] controlled:Gene_or_gene_productt-interceding-token ngrams: reduced p53 bindingtte1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] Gene_or_gene_productt)interceding-token ngrams: p53 activity ortle1: trigger-arg-path: enhance:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='p53'] controlledt)interceding-token ngrams: its target genet(interceding-token ngrams: binding to itst+interceding-token ngrams: the inhibition oftninterceding-tokens-full-span: . In our study , since blockade of autocrine TGF-beta signaling with DNRII expression or RIKI treatment did not significantly change total p53 levels without or with mitomycin C treatment , the reduced p53 binding to its target gene promoters in DNRII expressing cells was likely due to the inhibition of p53 activity or the blockade oftQe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='smad2'] controllert[e2: trigger-arg-path: binding:Binding prep_to >poss theme:Generic_entityt.interceding-token ngrams: signaling with DNRIIt)interceding-token ngrams: activity or thet*interceding-token ngrams: total p53 levelst&interceding-token ngrams: the blockadetXe1: trigger-arg-path: enhance:Positive_activation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='element'] >poss [lemma='its'] themetinterceding-token ngrams: totaltMe1: trigger-arg-path: enhance:Positive_activation >nsubj Gene_or_gene_productt,interceding-token ngrams: p53 levels withoutt)interceding-token ngrams: the reduced p53t*interceding-token ngrams: expressing cellst?e2: trigger-arg-path: binding:Binding prep_to [lemma='element'] >poss [lemma='its'] theme:Generic_entityt$interceding-token ngrams: was likelyt)interceding-token ngrams: the blockade oft/interceding-token ngrams: mitomycin C treatmenttRe2: trigger-arg-path: binding:Binding >nn [lemma='p53'] theme:Gene_or_gene_productt(interceding-token ngrams: levels withoutt+interceding-token ngrams: or RIKI treatmentt7e1: trigger-arg-path: enhance >dobj >prep_of controlledt!interceding-token ngrams: study ,t+interceding-token ngrams: inhibition of p53t interceding-token ngrams: changetMe2: trigger-arg-path: binding prep_to >poss Generic_entityt+interceding-token ngrams: or with mitomycint/e1: trigger-arg-path: enhance >nsubj controllert`e1: trigger-arg-path: enhance:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt?e2: trigger-arg-path: Binding prep_to [lemma='element'] >poss [lemma='its'] theme:Generic_entityt:e1: ents2Label-mention-ngram: the transcriptional activitytbe1: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] Gene_or_gene_productthe1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='smad2'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: also enhancet0e1: args2Role-mention-ngram: the transcriptionalt$interceding-token ngrams: likely duet.interceding-token ngrams: expressing cells wast&interceding-token ngrams: of autocrinetXe1: trigger-arg-path: enhance >dobj [lemma='activity'] >prep_of [lemma='p53'] controlledtinterceding-token ngrams: DNRIIt%interceding-token ngrams: mitomycin Ct?e2: trigger-arg-path: binding prep_to [lemma='element'] >poss [lemma='its'] themet interceding-token ngrams: In ourt#interceding-token ngrams: mitomycint/e2: ents2Label-mention-ngram: to GENERIC_ENTITYt^e1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of controlled:Gene_or_gene_productt+interceding-token ngrams: to the inhibitiont9e1: ents2Label-mention-ngram: enhance the transcriptionalt?e2: trigger-arg-path: binding prep_to [lemma='element'] >poss [lemma='its'] theme:Generic_entitytre1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj >prep_of controlledtUe2: trigger-arg-path: binding:Binding prep_to >poss Generic_entitytDe2: trigger-arg-path: binding prep_to >poss themet.CSSPATH: ROOT >ccomp ++ ROOT >prep_to >prep_oftee2: trigger-arg-path: lemmatizedTrigger=binding prep_to >poss theme:Generic_entityt*interceding-token ngrams: DNRII expressingtKe1: trigger-arg-path: Positive_activation >nsubj [lemma='smad2'] controllert+interceding-token ngrams: since blockade oft"interceding-token ngrams: . In ourt%interceding-token ngrams: target genet(interceding-token ngrams: gene promoterst$interceding-token ngrams: without ort(interceding-token ngrams: RIKI treatmentt'interceding-token ngrams: C treatment ,t/interceding-token ngrams: with DNRII expressiontLe2: trigger-arg-path: binding:Binding >nn [lemma='p53'] Gene_or_gene_productt*interceding-token ngrams: cells was likelytoe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='smad2'] Gene_or_gene_productt6interceding-token ngrams: autocrine TGF-beta signalingt)interceding-token ngrams: or the blockadet.e1: ents2Label-mention-ngram: also enhance thetSe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of Gene_or_gene_productt0e1: ents2Label-mention-ngram: activity of SHAREDt]e1: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='smad2'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj >prep_of controlledt(interceding-token ngrams: with mitomycintDe2: trigger-arg-path: binding >nn [lemma='p53'] Gene_or_gene_producttMe2: trigger-arg-path: Binding prep_to >poss Generic_entityt-interceding-token ngrams: of COX-2 expressiont!interceding-token ngrams: We alsot'interceding-token ngrams: translocationt interceding-token ngrams: and bytke2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet'interceding-token ngrams: at mRNA levelt?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt$interceding-token ngrams: at proteintEe2: trigger-arg-path: Binding prep_to >nn Gene_or_gene_productt%interceding-token ngrams: cytosol andt/interceding-token ngrams: stimulating NF-kappaBt*interceding-token ngrams: treatment of BBRt!interceding-token ngrams: only attwe1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn themet?e1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlled:Gene_or_gene_productt1interceding-token ngrams: mediated by stimulatingt.interceding-token ngrams: suppression of COX-2tKe2: trigger-arg-path: Binding prep_to >nn theme:Gene_or_gene_productt!interceding-token ngrams: level ,tinterceding-token ngrams: onlyt6e2: trigger-arg-path: binding prep_to >nn themetKe2: trigger-arg-path: binding prep_to >nn theme:Gene_or_gene_productt-interceding-token ngrams: expression not onlyt-interceding-token ngrams: that the inhibitiont interceding-token ngrams: BBR ist/interceding-token ngrams: could exert antitumort interceding-token ngrams: of BBRt+interceding-token ngrams: partially throught-interceding-token ngrams: inhibition of COX-2t*interceding-token ngrams: at protein levelt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlled:Gene_or_gene_producttce1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlledtie1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >nn [lemma='cox-2'] controlledt&interceding-token ngrams: mRNA level ,t)interceding-token ngrams: also found thatt(interceding-token ngrams: that BBR couldt*interceding-token ngrams: antitumor effectt(interceding-token ngrams: to cytosol andt'interceding-token ngrams: We also foundt%interceding-token ngrams: could exertt1interceding-token ngrams: NF-kappaB translocationtze2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt+interceding-token ngrams: and by inhibitingt?e2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binding:Binding prep_to >nn Gene_or_gene_producttinterceding-token ngrams: BBRt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet0CSSPATH: ROOT >ccomp ++ ROOT >ccomp >agent >dobjt)interceding-token ngrams: only at proteint}e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt%interceding-token ngrams: but also att'interceding-token ngrams: protein levelt+interceding-token ngrams: COX-2 signaling .t,interceding-token ngrams: partially mediatedt4interceding-token ngrams: antitumor effect partiallytinterceding-token ngrams: exertt?e2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt"interceding-token ngrams: that BBRt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] Gene_or_gene_productt(interceding-token ngrams: level but alsot"interceding-token ngrams: of COX-2t(interceding-token ngrams: by stimulatingt!interceding-token ngrams: at mRNAt(interceding-token ngrams: found that thettinterceding-tokens-full-span: expression not only at protein level but also at mRNA level , suggesting that BBR could exert antitumor effect partially through suppression of COX-2 signaling . We also found that the inhibition of COX-2 expression by treatment of BBR is partially mediated by stimulating NF-kappaB translocation from nuclear to cytosol and by inhibiting thet(interceding-token ngrams: suppression oft7interceding-token ngrams: partially through suppressiont#interceding-token ngrams: . We alsot=interceding-token ngrams: stimulating NF-kappaB translocationt#interceding-token ngrams: partiallyt(interceding-token ngrams: expression nott(interceding-token ngrams: signaling . Wetee2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to >nn Gene_or_gene_productt&interceding-token ngrams: by treatmentt,interceding-token ngrams: translocation fromt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt$interceding-token ngrams: to cytosolt&interceding-token ngrams: also at mRNAt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn Gene_or_gene_productt-interceding-token ngrams: suggesting that BBRt+interceding-token ngrams: by inhibiting thet#interceding-token ngrams: level buttke2: trigger-arg-path: binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet%interceding-token ngrams: suppressiont)interceding-token ngrams: from nuclear tot'interceding-token ngrams: expression bytYe1: trigger-arg-path: inhibited >dobj [lemma='expression'] >nn [lemma='cox-2'] controlledtEe2: trigger-arg-path: binding prep_to >nn Gene_or_gene_productt)interceding-token ngrams: BBR could exertt2interceding-token ngrams: by stimulating NF-kappaBt)interceding-token ngrams: COX-2 signalingtHe2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn themet$interceding-token ngrams: mRNA levelt*interceding-token ngrams: BBR is partiallytSe2: trigger-arg-path: binding:Binding prep_to >nn theme:Gene_or_gene_productt%interceding-token ngrams: not only att2interceding-token ngrams: effect partially throught+interceding-token ngrams: protein level butt#interceding-token ngrams: BBR couldt*interceding-token ngrams: effect partiallyt)interceding-token ngrams: exert antitumort]e2: trigger-arg-path: lemmatizedTrigger=binding prep_to >nn theme:Gene_or_gene_productt,interceding-token ngrams: level , suggestingt!interceding-token ngrams: also att$interceding-token ngrams: also foundt&interceding-token ngrams: is partiallyt*interceding-token ngrams: COX-2 expressiont(interceding-token ngrams: cytosol and byt-interceding-token ngrams: through suppressiont,interceding-token ngrams: nuclear to cytosoltme1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlledtme1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] Gene_or_gene_producttce1: trigger-arg-path: inhibited >dobj [lemma='expression'] >nn [lemma='cox-2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] theme:Gene_or_gene_productt"interceding-token ngrams: not onlyt#interceding-token ngrams: antitumort>e2: trigger-arg-path: binding:Binding prep_to >nn themet1interceding-token ngrams: expression by treatmentt}e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlledtne1: trigger-arg-path: inhibited >dobj [lemma='expression'] >nn [lemma='cox-2'] controlled:Gene_or_gene_productt0interceding-token ngrams: exert antitumor effectt&interceding-token ngrams: from nucleart)interceding-token ngrams: by treatment oft/interceding-token ngrams: is partially mediatedt0interceding-token ngrams: through suppression oft(interceding-token ngrams: inhibiting thet%interceding-token ngrams: stimulatingt4interceding-token ngrams: translocation from nucleart6interceding-token ngrams: NF-kappaB translocation fromt$interceding-token ngrams: nuclear tot6e2: trigger-arg-path: Binding prep_to >nn themet'interceding-token ngrams: by inhibitingtse2: trigger-arg-path: binding:Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] themet,interceding-token ngrams: of COX-2 signalingt/interceding-token ngrams: partially mediated bytinterceding-token ngrams: COX-2t~e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >nn [lemma='cox-2'] controlled:Gene_or_gene_productt#interceding-token ngrams: of BBR istxe1: trigger-arg-path: Negative_activation >dobj [lemma='expression'] >nn [lemma='cox-2'] controlled:Gene_or_gene_productt-interceding-token ngrams: COX-2 expression bytze2: trigger-arg-path: Binding prep_to [lemma='promoter'] >nn [lemma='cox-2'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='expression'] >nn [lemma='cox-2'] Gene_or_gene_productt>e2: trigger-arg-path: associates >nsubj [lemma='Merlin'] themetIe1: trigger-arg-path: targets >nsubj [lemma='Group'] Gene_or_gene_productt,e1: trigger-arg-path: targets >prep_of themet_e2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='pak'] Gene_or_gene_productt\e2: trigger-arg-path: associates:Binding >prep_with [lemma='pak'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_productt[e2: trigger-arg-path: associates:Binding >nsubj [lemma='Merlin'] theme:Gene_or_gene_producttprep_with [lemma='pak'] themetOe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='Merlin'] themetVe2: trigger-arg-path: associates:Binding >prep_with [lemma='pak'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='pak'] themetAe1: trigger-arg-path: targets >prep_of theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: THEME aret,e1: ents2Label-mention-ngram: are downstreamtNe2: trigger-arg-path: associates >prep_with [lemma='pak'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] themetIe1: trigger-arg-path: Binding >nsubj [lemma='Group'] Gene_or_gene_productt2e1: trigger-arg-path: targets:Binding >nsubj themetee1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] Gene_or_gene_productt;e1: trigger-arg-path: targets >prep_of Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='Merlin'] Gene_or_gene_producttQe1: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: targets oft2e1: args2Role-mention-ngram: downstream targets oftOe1: trigger-arg-path: targets >nsubj [lemma='Group'] theme:Gene_or_gene_producttBe2: trigger-arg-path: associates >nsubj theme:Gene_or_gene_producttnsubj Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_with [lemma='pak'] Gene_or_gene_producttSe2: trigger-arg-path: associates >nsubj [lemma='Merlin'] theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: associates with inactivet?e1: trigger-arg-path: targets >nsubj theme:Gene_or_gene_producttRe1: trigger-arg-path: targets >prep_of [lemma='Merlin'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] Gene_or_gene_productt'e1: args2Role-mention-ngram: targets oft;e2: ents2Label-mention-ngram: inactive GENE_OR_GENE_PRODUCTt3e1: ents2Label-mention-ngram: downstream targets oft5e2: args2Role-mention-ngram: associates with inactivethe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='Merlin'] Gene_or_gene_productt$e1: args2Role-mention-ngram: targetstUe2: trigger-arg-path: associates:Binding >nsubj [lemma='Merlin'] Gene_or_gene_productt3e1: args2Role-mention-ngram: are downstream targetst/e1: ents2Label-mention-ngram: targets of SHAREDt%e1: ents2Label-mention-ngram: targetstAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT are downstreamt4e1: ents2Label-mention-ngram: are downstream targetst2e2: args2Role-mention-ngram: THEME associates witht-e2: args2Role-mention-ngram: THEME associatest4e1: trigger-arg-path: targets:Binding >prep_of themet:e1: trigger-arg-path: Binding >nsubj [lemma='Group'] themetge2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='pak'] Gene_or_gene_productt=e1: trigger-arg-path: targets >prep_of [lemma='Merlin'] themetWe1: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: with inactivetFe2: trigger-arg-path: associates:Binding >nsubj [lemma='Merlin'] themet9e1: trigger-arg-path: targets >nsubj Gene_or_gene_productte1: incoming: prep_with [lemma='pak'] themetme2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='pak'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] theme:Gene_or_gene_producttLe1: trigger-arg-path: targets >prep_of [lemma='Merlin'] Gene_or_gene_producttAe1: trigger-arg-path: targets:Binding >nsubj Gene_or_gene_productt/e1: args2Role-mention-ngram: downstream targetstTe1: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] Gene_or_gene_producttJe2: trigger-arg-path: associates:Binding >nsubj theme:Gene_or_gene_producttGe1: trigger-arg-path: targets:Binding >nsubj theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: with inactive THEMEtLe1: trigger-arg-path: Binding >prep_of [lemma='Merlin'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='Group'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: THEME are downstreamtee2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='pak'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='Merlin'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] themetDe2: trigger-arg-path: associates:Binding >nsubj Gene_or_gene_productt+e2: ents2Label-mention-ngram: with inactivetPe2: trigger-arg-path: Binding >nsubj [lemma='Merlin'] theme:Gene_or_gene_producttIe1: trigger-arg-path: targets:Binding >prep_of theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: are downstreamtQe2: trigger-arg-path: Binding >prep_with [lemma='pak'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='pak'] themet+e2: args2Role-mention-ngram: inactive THEMEt0e1: ents2Label-mention-ngram: downstream targetstde2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='Merlin'] theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >nsubj [lemma='Merlin'] themetNe1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] themetMe2: trigger-arg-path: associates >nsubj [lemma='Merlin'] Gene_or_gene_producttBe1: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] themetke1: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_productte1: trigger: targetstbe1: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] Gene_or_gene_producttEe1: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] themet6e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT aret/e2: ents2Label-mention-ngram: SHARED associatest?e2: trigger-arg-path: associates >prep_with [lemma='pak'] themetCe1: trigger-arg-path: targets:Binding >prep_of Gene_or_gene_productt4e2: ents2Label-mention-ngram: SHARED associates witht:e1: trigger-arg-path: targets >nsubj [lemma='Group'] themet-e1: args2Role-mention-ngram: targets of THEMEtZe1: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='Merlin'] themet@e2: ents2Label-mention-ngram: with inactive GENE_OR_GENE_PRODUCTtKe1: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] themet*e1: trigger-arg-path: targets >nsubj themet=e1: trigger-arg-path: Binding >prep_of [lemma='Merlin'] themetle2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='Merlin'] theme:Gene_or_gene_producttTe2: trigger-arg-path: associates >prep_with [lemma='pak'] theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >prep_between [lemma='pgam'] theme:Familyt'e1: ents2Label-mention-ngram: abrogatedt3e1: ents2Label-mention-ngram: physical interactionstge1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controllertUe2: trigger-arg-path: Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttge1: trigger-arg-path: abrogated >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] Gene_or_gene_productt*interceding-token ngrams: on these resultst|e1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controller:Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER abrogated thetke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam'] Familyt1e1: args2Role-mention-ngram: CONTROLLER abrogatedtinterceding-token ngrams: Basedt"interceding-token ngrams: on thesetKe2: trigger-arg-path: interaction >prep_between [lemma='pgam'] theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controller:Gene_or_gene_producttXe1: trigger-arg-path: abrogated:Positive_regulation >nsubj >prep_of Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mdm2'] Gene_or_gene_productt*e1: args2Role-mention-ngram: abrogated thet]e1: trigger-arg-path: abrogated >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controllert7e1: ents2Label-mention-ngram: the physical interactionst@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT abrogated thetVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mdm2'] themet@e2: trigger-arg-path: Binding >prep_between [lemma='mdm2'] themetme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt:e1: trigger-arg-path: abrogated >nsubj >prep_of controllert(interceding-token ngrams: , we concludedtVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam'] themet0e1: args2Role-mention-ngram: physical CONTROLLEDtxe1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] Gene_or_gene_productt@e2: trigger-arg-path: Binding >prep_between [lemma='pgam'] themetSe2: trigger-arg-path: interaction >prep_between [lemma='mdm2'] Gene_or_gene_productt$interceding-token ngrams: . Based ont?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam'] theme:Familytccomp ++ ROOT >ccomp >nsubjpasstWinterceding-tokens-full-span: . Based on these results , we concluded that the physicaltAe2: trigger-arg-path: Binding >prep_between [lemma='pgam'] Familyt?e1: trigger-arg-path: abrogated:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controllert,interceding-token ngrams: concluded that thetEe2: trigger-arg-path: interaction >prep_between [lemma='pgam'] Familyte1: trigger: abrogatedtqe1: trigger-arg-path: abrogated:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controllertWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam'] Familyt4e1: args2Role-mention-ngram: the physical CONTROLLEDt{e1: trigger-arg-path: abrogated:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: physical interactions betweentse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt+interceding-token ngrams: we concluded thattLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='mdm2'] themetSe2: trigger-arg-path: interaction:Binding >prep_between [lemma='pgam'] theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controller:Gene_or_gene_producttae2: trigger-arg-path: interaction:Binding >prep_between [lemma='mdm2'] theme:Gene_or_gene_productt+interceding-token ngrams: that the physicaltLe2: trigger-arg-path: interaction:Binding >prep_between [lemma='pgam'] themet3e1: args2Role-mention-ngram: abrogated the physicaltYe2: trigger-arg-path: interaction >prep_between [lemma='mdm2'] theme:Gene_or_gene_producttMe2: trigger-arg-path: interaction:Binding >prep_between [lemma='pgam'] Familyt4e1: ents2Label-mention-ngram: abrogated the physicalt[e2: trigger-arg-path: interaction:Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mdm2'] themet]e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pgam'] theme:Familyt#interceding-token ngrams: concludedt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pgam'] themetDe1: trigger-arg-path: abrogated >nsubj >prep_of Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controllert+e1: ents2Label-mention-ngram: abrogated thetqe1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] Gene_or_gene_productt!interceding-token ngrams: . Basedt(interceding-token ngrams: Based on thesetNe1: trigger-arg-path: abrogated:Positive_regulation >nsubj >prep_of controllertOe2: trigger-arg-path: Binding >prep_between [lemma='mdm2'] Gene_or_gene_productt&e1: args2Role-mention-ngram: abrogatedtDe2: trigger-arg-path: interaction >prep_between [lemma='mdm2'] themet&interceding-token ngrams: we concludedtre1: trigger-arg-path: abrogated >nsubj [lemma='knockdown'] >prep_of [lemma='pak1'] controller:Gene_or_gene_producttce1: trigger-arg-path: abrogated:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttDe2: trigger-arg-path: interaction >prep_between [lemma='pgam'] themet"interceding-token ngrams: Based ont#interceding-token ngrams: results ,t(interceding-token ngrams: concluded thattOe1: trigger-arg-path: abrogated >nsubj >prep_of controller:Gene_or_gene_productt)interceding-token ngrams: these results ,t4interceding-token ngrams: detachment induces releaset\e1: trigger-arg-path: lemmatizedTrigger=sequester >agent >nn controller:Gene_or_gene_productt)interceding-token ngrams: attached to ECMt interceding-token ngrams: of Bimt7e1: trigger-arg-path: sequestered >agent >nn controllert+e1: args2Role-mention-ngram: is sequesteredtee1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass Gene_or_gene_producttAe1: trigger-arg-path: sequestered >agent >nn Gene_or_gene_productt-interceding-token ngrams: to the mitochondriat~e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass [lemma='Bim'] controlled:Gene_or_gene_productt"interceding-token ngrams: to ECM .t?e2: trigger-arg-path: Binding >prep_with [lemma='bcl-xl'] themet6e1: args2Role-mention-ngram: CONTROLLED is sequesteredt%interceding-token ngrams: attached totce1: trigger-arg-path: sequestered:Positive_activation >nsubjpass [lemma='Bim'] Gene_or_gene_producttle1: trigger-arg-path: Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] Gene_or_gene_producttinterceding-token ngrams: BimtPe2: trigger-arg-path: interacts >prep_with [lemma='bcl-xl'] Gene_or_gene_producttIe2: trigger-arg-path: interacts:Binding >prep_with [lemma='bcl-xl'] themette1: trigger-arg-path: lemmatizedTrigger=sequester >agent [lemma='complex'] >nn [lemma='dynein'] Gene_or_gene_productt interceding-token ngrams: . CelltTe2: trigger-arg-path: Binding >prep_with [lemma='bcl-xl'] theme:Gene_or_gene_productt^e2: trigger-arg-path: interacts:Binding >prep_with [lemma='bcl-xl'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass controlled:Gene_or_gene_productt"interceding-token ngrams: attachedt.e1: args2Role-mention-ngram: is sequestered byt(interceding-token ngrams: Bim from thesetKe1: trigger-arg-path: sequestered:Positive_activation >agent >nn controllert*interceding-token ngrams: the mitochondriatVe2: trigger-arg-path: interacts >prep_with [lemma='bcl-xl'] theme:Gene_or_gene_productt+interceding-token ngrams: . Cell detachmentt7e1: trigger-arg-path: sequestered >nsubjpass controlledtoe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bcl-xl'] theme:Gene_or_gene_producttZe1: trigger-arg-path: sequestered >nsubjpass [lemma='Bim'] controlled:Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='Bim'] controlled:Gene_or_gene_producttne1: trigger-arg-path: sequestered:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controllert$interceding-token ngrams: ECM . Cellt?e1: trigger-arg-path: sequestered:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controller:Gene_or_gene_productt#interceding-token ngrams: cells aretAe1: ents2Label-mention-ngram: sequestered by GENE_OR_GENE_PRODUCTt0CSSPATH: ROOT  ++ ROOT >conj_and >prep_to >rcmodt)interceding-token ngrams: induces releaset$interceding-token ngrams: when cellstKe1: trigger-arg-path: sequestered:Positive_activation >nsubjpass controlledtde1: trigger-arg-path: sequestered >agent [lemma='complex'] >nn [lemma='dynein'] Gene_or_gene_producttinterceding-token ngrams: ECM .tge2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bcl-xl'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass Gene_or_gene_producttUe1: trigger-arg-path: sequestered:Positive_activation >nsubjpass Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=sequester >agent [lemma='complex'] >nn [lemma='dynein'] controllertAe2: trigger-arg-path: interacts >prep_with [lemma='bcl-xl'] themetpe1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent >nn controller:Gene_or_gene_productt?interceding-tokens-full-span: cytoskeletal complexes when cells are attached to ECM . Cell detachment induces release of Bim from these complexes and causes its translocation to the mitochondria , wheret,e1: ents2Label-mention-ngram: is sequesteredt)interceding-token ngrams: Cell detachmentt6e1: args2Role-mention-ngram: sequestered by CONTROLLERt*interceding-token ngrams: translocation tot.interceding-token ngrams: complexes and causestse1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass [lemma='Bim'] Gene_or_gene_productt5interceding-token ngrams: cytoskeletal complexes whent[e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent >nn controllert.interceding-token ngrams: from these complexest,interceding-token ngrams: cells are attachedtRe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bcl-xl'] themet`e1: trigger-arg-path: sequestered:Positive_activation >agent >nn controller:Gene_or_gene_productt1interceding-token ngrams: Cell detachment inducest,interceding-token ngrams: the mitochondria ,t,interceding-token ngrams: induces release oft3e1: ents2Label-mention-ngram: SHARED is sequesteredtpe1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass controlled:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=sequester >agent >nn controllert-interceding-token ngrams: these complexes andtinterceding-token ngrams: ECMt(interceding-token ngrams: complexes whent/e1: ents2Label-mention-ngram: is sequestered byte1: trigger-arg-path: lemmatizedTrigger=sequester >agent [lemma='complex'] >nn [lemma='dynein'] controller:Gene_or_gene_producttNe2: trigger-arg-path: Binding >prep_with [lemma='bcl-xl'] Gene_or_gene_productt(interceding-token ngrams: and causes itst(interceding-token ngrams: when cells aretee1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent >nn Gene_or_gene_producttne1: trigger-arg-path: sequestered:Positive_activation >nsubjpass [lemma='Bim'] controlled:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass controlledtUe1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass [lemma='Bim'] controlledt~e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controllertxe1: trigger-arg-path: sequestered:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] Gene_or_gene_productt(interceding-token ngrams: release of Bimt`e1: trigger-arg-path: sequestered:Positive_activation >nsubjpass controlled:Gene_or_gene_producttYe1: trigger-arg-path: sequestered:Positive_activation >nsubjpass [lemma='Bim'] controlledt$interceding-token ngrams: detachmenttAe1: trigger-arg-path: sequestered >nsubjpass Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >nsubjpass [lemma='Bim'] controlledtGe1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass controlledt_e1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass [lemma='Bim'] Gene_or_gene_producttLe1: trigger-arg-path: sequestered >agent >nn controller:Gene_or_gene_producttXe2: trigger-arg-path: interacts:Binding >prep_with [lemma='bcl-xl'] Gene_or_gene_producttWe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='Bim'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=sequester >nsubjpass [lemma='Bim'] controlled:Gene_or_gene_productt$interceding-token ngrams: causes itstae2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='bcl-xl'] Gene_or_gene_producttoe1: trigger-arg-path: sequestered >agent [lemma='complex'] >nn [lemma='dynein'] controller:Gene_or_gene_producttOe1: trigger-arg-path: sequestered >nsubjpass [lemma='Bim'] Gene_or_gene_productt2interceding-token ngrams: causes its translocationtEe1: trigger-arg-path: sequestered >nsubjpass [lemma='Bim'] controlledt.interceding-token ngrams: complexes when cellst(interceding-token ngrams: mitochondria ,tMe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='Bim'] controlledtZe1: trigger-arg-path: sequestered >agent [lemma='complex'] >nn [lemma='dynein'] controllert"interceding-token ngrams: Bim fromt,interceding-token ngrams: detachment inducest+interceding-token ngrams: its translocationt.interceding-token ngrams: mitochondria , wheretinterceding-token ngrams: CelltZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bcl-xl'] themetLe1: trigger-arg-path: sequestered >nsubjpass controlled:Gene_or_gene_productt.interceding-token ngrams: its translocation tot)interceding-token ngrams: are attached tot?e1: trigger-arg-path: lemmatizedTrigger=sequester:Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controllert0interceding-token ngrams: cytoskeletal complexest interceding-token ngrams: to ECMt&interceding-token ngrams: are attachedtie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='bcl-xl'] Gene_or_gene_productt$interceding-token ngrams: and causestQe1: trigger-arg-path: lemmatizedTrigger=sequester >agent >nn Gene_or_gene_productt.interceding-token ngrams: translocation to thet%interceding-token ngrams: of Bim fromtwe1: trigger-arg-path: Positive_activation >agent [lemma='complex'] >nn [lemma='dynein'] controller:Gene_or_gene_producttUe1: trigger-arg-path: sequestered:Positive_activation >agent >nn Gene_or_gene_producttinterceding-token ngrams: K-RASt/interceding-token ngrams: such as proliferationtFe2: trigger-arg-path: lemmatizedTrigger=stimulate nn controlledt'interceding-token ngrams: codons 12 andtne1: trigger-arg-path: bound:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] theme:Gene_or_gene_productt interceding-token ngrams: MAPK )t(interceding-token ngrams: processes suchtMe2: trigger-arg-path: Positive_regulation >agent [lemma='protein'] controllertme2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='protein'] controller:Gene_or_gene_productt,interceding-token ngrams: Mutations in K-RASt#interceding-token ngrams: canonicalthe1: trigger-arg-path: bound:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] Gene_or_gene_productt(interceding-token ngrams: and survival .tje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] themetinterceding-token ngrams: 12t"interceding-token ngrams: found att}e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn [lemma='gtp'] controlledt$interceding-token ngrams: survival .tXe2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='protein'] controllert"interceding-token ngrams: cascadest$interceding-token ngrams: MAPK ) andtDe2: trigger-arg-path: stimulated >agent [lemma='protein'] controllertqe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='protein'] Gene_or_gene_productt1interceding-token ngrams: including the canonicaltle2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent controller:Gene_or_gene_producttSe1: trigger-arg-path: Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] themetTe2: trigger-arg-path: stimulated:Positive_regulation nn controlled:Hydrolysistie2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='protein'] controllert2e2: args2Role-mention-ngram: CONTROLLED stimulatedt+interceding-token ngrams: and PI3K-Akt-mTORt)interceding-token ngrams: most frequentlytWe2: trigger-arg-path: Positive_regulation >agent [lemma='protein'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn controlled:Hydrolysist)interceding-token ngrams: , including thet+interceding-token ngrams: regulate cellulart#interceding-token ngrams: codons 12t#interceding-token ngrams: processest(interceding-token ngrams: . Mutations int,interceding-token ngrams: cellular processest$interceding-token ngrams: cascades ,twe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] theme:Gene_or_gene_productt+interceding-token ngrams: 13 and compromiset-interceding-token ngrams: ) and PI3K-Akt-mTORtXe2: trigger-arg-path: stimulated nn [lemma='gtp'] Hydrolysist1interceding-token ngrams: canonical Raf-MEK-ERK (t&interceding-token ngrams: Mutations intfe1: trigger-arg-path: bound >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] theme:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='protein'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='protein'] controller:Gene_or_gene_producttbe2: trigger-arg-path: Positive_regulation >agent [lemma='protein'] controller:Gene_or_gene_productt#interceding-token ngrams: Mutationstte2: trigger-arg-path: lemmatizedTrigger=stimulate nn [lemma='gtp'] controlled:Hydrolysist@e2: trigger-arg-path: stimulated nn controlled:Hydrolysist+interceding-token ngrams: processes such ast`e1: trigger-arg-path: bound >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] Gene_or_gene_productthe1: trigger-arg-path: Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] theme:Gene_or_gene_productt$interceding-token ngrams: frequentlytIe2: trigger-arg-path: Positive_regulation nn controlled:Hydrolysist/interceding-token ngrams: most frequently foundt interceding-token ngrams: and 13t>e2: trigger-arg-path: Positive_regulation nn Hydrolysist-interceding-token ngrams: are most frequentlytNe2: trigger-arg-path: stimulated >agent [lemma='protein'] Gene_or_gene_productt4interceding-token ngrams: and PI3K-Akt-mTOR pathwayst*interceding-token ngrams: as proliferationtWe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent controllert'interceding-token ngrams: Raf-MEK-ERK (t%interceding-token ngrams: . Mutationst4interceding-token ngrams: various signaling cascadestse2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='protein'] Gene_or_gene_productt1interceding-token ngrams: cellular processes sucht'interceding-token ngrams: the canonicaltQe2: trigger-arg-path: lemmatizedTrigger=stimulate nn controlled:HydrolysistYe2: trigger-arg-path: stimulated >agent [lemma='protein'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn [lemma='gtp'] controlled:Hydrolysist6e2: ents2Label-mention-ngram: hydrolysis stimulated bytle2: trigger-arg-path: stimulated:Positive_regulation nn [lemma='gtp'] HydrolysistXe2: trigger-arg-path: stimulated nn [lemma='gtp'] controlledtIe2: trigger-arg-path: stimulated:Positive_regulation nn Hydrolysist interceding-token ngrams: codonstae2: trigger-arg-path: Positive_regulation nn [lemma='gtp'] Hydrolysist+interceding-token ngrams: activates varioust5e2: trigger-arg-path: stimulated nn Hydrolysist"interceding-token ngrams: in K-RAStie2: trigger-arg-path: lemmatizedTrigger=stimulate nn [lemma='gtp'] Hydrolysist:e2: ents2Label-mention-ngram: SHARED hydrolysis stimulatedt interceding-token ngrams: ( MAPKt interceding-token ngrams: 12 andt'interceding-token ngrams: , to regulatetZe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn Hydrolysist+interceding-token ngrams: proliferation andtUe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='protein'] controllert3e2: ents2Label-mention-ngram: hydrolysis stimulatedt"interceding-token ngrams: ( MAPK )t5interceding-token ngrams: activates various signalingt(interceding-token ngrams: and compromisete1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent Gene_or_gene_productt$interceding-token ngrams: and 13 andtie2: trigger-arg-path: lemmatizedTrigger=stimulate nn [lemma='gtp'] controlledtbe1: trigger-arg-path: Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation nn [lemma='gtp'] controlledt5e2: trigger-arg-path: stimulated nn controlledt.interceding-token ngrams: signaling cascades ,tYe1: trigger-arg-path: bound:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] themet.interceding-token ngrams: to regulate cellulart+interceding-token ngrams: various signalingtle2: trigger-arg-path: stimulated:Positive_regulation nn [lemma='gtp'] controlledt3interceding-token ngrams: the canonical Raf-MEK-ERKt2interceding-token ngrams: PI3K-Akt-mTOR pathways ,t4interceding-token ngrams: proliferation and survivaltQe1: trigger-arg-path: bound >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] themet'interceding-token ngrams: pathways , totce2: trigger-arg-path: stimulated nn [lemma='gtp'] controlled:Hydrolysistle2: trigger-arg-path: Positive_regulation nn [lemma='gtp'] controlled:HydrolysistPe2: trigger-arg-path: stimulated:Positive_regulation >agent Gene_or_gene_productt#interceding-token ngrams: 12 and 13tFe2: trigger-arg-path: lemmatizedTrigger=stimulate nn Hydrolysist)interceding-token ngrams: found at codonst.interceding-token ngrams: survival . Mutationst$interceding-token ngrams: pathways ,t#interceding-token ngrams: K-RAS aret(interceding-token ngrams: K-RAS are mostt0interceding-token ngrams: PI3K-Akt-mTOR pathwayst'interceding-token ngrams: PI3K-Akt-mTORtIe2: trigger-arg-path: stimulated:Positive_regulation nn controlledtFe2: trigger-arg-path: stimulated:Positive_regulation >agent controllert5e2: args2Role-mention-ngram: CONTROLLED stimulated bytye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn [lemma='gtp'] Hydrolysist$interceding-token ngrams: compromiset"interceding-tokens-full-span: activates various signaling cascades , including the canonical Raf-MEK-ERK ( MAPK ) and PI3K-Akt-mTOR pathways , to regulate cellular processes such as proliferation and survival . Mutations in K-RAS are most frequently found at codons 12 and 13 and compromiset.interceding-token ngrams: as proliferation andt.interceding-token ngrams: cascades , includingt interceding-token ngrams: 13 andtZe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nn controlledt[e2: trigger-arg-path: stimulated:Positive_regulation >agent controller:Gene_or_gene_productt&interceding-token ngrams: at codons 12tinterceding-token ngrams: 13t,interceding-token ngrams: Raf-MEK-ERK ( MAPKt%CSSPATH: ROOT  ++ ROOT >prep_at >vmodt5interceding-token ngrams: regulate cellular processest*interceding-token ngrams: frequently foundt&interceding-token ngrams: in K-RAS aret&interceding-token ngrams: and survivalt,interceding-token ngrams: signaling cascadest'interceding-token ngrams: including thet-interceding-token ngrams: frequently found att/interceding-token ngrams: canonical Raf-MEK-ERKtbe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='activate'] >nsubj [lemma='k-ra'] themet#interceding-token ngrams: at codonst"interceding-token ngrams: are mosttbe2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='protein'] Gene_or_gene_producttwe2: trigger-arg-path: stimulated:Positive_regulation nn [lemma='gtp'] controlled:Hydrolysist%interceding-token ngrams: Raf-MEK-ERKt+e1: args2Role-mention-ngram: HIPK2 activityt!interceding-token ngrams: enhancet-interceding-token ngrams: further enhance DNAtwe1: trigger-arg-path: leads:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] Phosphorylationt1e1: args2Role-mention-ngram: to direct CONTROLLEDtFe1: trigger-arg-path: Positive_regulation >xcomp >dobj Phosphorylationt(interceding-token ngrams: as revealed byt:interceding-token ngrams: These N-terminal phosphorylationtHe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj Gene_or_gene_productt)e2: ents2Label-mention-ngram: SUMOylationt\e1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttHe1: trigger-arg-path: leads >nsubj [lemma='damage'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: direct SHAREDt#interceding-token ngrams: Gresko ettae1: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_producttce1: trigger-arg-path: leads >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] Phosphorylationt\e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='damage'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: leads to directt)e1: args2Role-mention-ngram: and leads tot8e2: ents2Label-mention-ngram: induced SHARED SUMOylationt:interceding-token ngrams: N-terminal phosphorylation sitest?e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlledt'interceding-token ngrams: serines 8 andt?e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationthe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp >dobj controlled:Phosphorylationt!interceding-token ngrams: serinest%interceding-token ngrams: ( Gresko ettde1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='damage'] controller:Gene_or_gene_productt"interceding-token ngrams: ( Greskotinterceding-token ngrams: 8 andtme1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj controller:Gene_or_gene_productt(interceding-token ngrams: 38 as revealedtVe1: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj controller:Gene_or_gene_productt&interceding-token ngrams: at serines 8tRe1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='damage'] controllertinterceding-token ngrams: 38t]e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp >dobj Phosphorylationt,e1: ents2Label-mention-ngram: HIPK2 activitytDe1: trigger-arg-path: lemmatizedTrigger=lead >xcomp >dobj controlledt/e1: args2Role-mention-ngram: activity and leadstLe1: trigger-arg-path: Positive_regulation >nsubj [lemma='damage'] controllert%interceding-token ngrams: as revealedt;e1: ents2Label-mention-ngram: direct SHARED phosphorylationt,interceding-token ngrams: . These N-terminalt"e1: args2Role-mention-ngram: HIPK2t)interceding-token ngrams: kinase assays (t(interceding-token ngrams: revealed by int+e1: ents2Label-mention-ngram: induces HIPK2t#e1: ents2Label-mention-ngram: HIPK2t?e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] PhosphorylationtKe1: trigger-arg-path: leads:Positive_regulation >nsubj Gene_or_gene_producttGe1: trigger-arg-path: leads:Positive_regulation >xcomp >dobj controlledtCe1: trigger-arg-path: leads >xcomp >dobj controlled:Phosphorylationt7e1: trigger-arg-path: leads >nsubj Gene_or_gene_producttinterceding-token ngrams: 8t?interceding-tokens-full-span: at serines 8 and 38 as revealed by in vitro kinase assays ( Gresko et al. , ) . These N-terminal phosphorylation sites further enhance DNAt.e1: ents2Label-mention-ngram: to direct SHAREDtBe1: trigger-arg-path: leads >nsubj controller:Gene_or_gene_producttQe1: trigger-arg-path: Positive_regulation >xcomp >dobj controlled:Phosphorylationt8e1: trigger-arg-path: leads >xcomp >dobj Phosphorylationt0e2: ents2Label-mention-ngram: SHARED SUMOylationt/e1: args2Role-mention-ngram: HIPK2 activity andt)interceding-token ngrams: assays ( Greskot2e1: ents2Label-mention-ngram: SHARED induces HIPK2t4interceding-token ngrams: N-terminal phosphorylationt*e1: ents2Label-mention-ngram: and leads tot%interceding-token ngrams: revealed byt0e1: ents2Label-mention-ngram: HIPK2 activity andt|e1: trigger-arg-path: Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlled:PhosphorylationtVe1: trigger-arg-path: leads:Positive_regulation >nsubj controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: induces HIPK2 activityt%interceding-token ngrams: enhance DNAt0e1: ents2Label-mention-ngram: activity and leadstre1: trigger-arg-path: leads:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlledt"interceding-token ngrams: assays (t5e1: args2Role-mention-ngram: CONTROLLER induces HIPK2tinterceding-token ngrams: 38 ast4e1: ents2Label-mention-ngram: induces HIPK2 activitytle1: trigger-arg-path: Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlledtIe1: trigger-arg-path: lemmatizedTrigger=lead >xcomp >dobj Phosphorylationtne1: trigger-arg-path: leads >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationt7interceding-token ngrams: phosphorylation sites furthert^e1: trigger-arg-path: leads >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlledt%interceding-token ngrams: by in vitrotinterceding-token ngrams: by intxe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=lead >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlled:Phosphorylationtoe1: trigger-arg-path: lemmatizedTrigger=lead >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlledtce1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >nsubj [lemma='damage'] controllert#interceding-token ngrams: ) . ThesetWe1: trigger-arg-path: leads:Positive_regulation >xcomp >dobj controlled:Phosphorylationt>e1: trigger-arg-path: leads >nsubj [lemma='damage'] controllert'interceding-token ngrams: kinase assayst&e1: args2Role-mention-ngram: to directt.e1: args2Role-mention-ngram: direct CONTROLLEDt)interceding-token ngrams: further enhancet"interceding-token ngrams: 8 and 38tTe1: trigger-arg-path: lemmatizedTrigger=lead >xcomp >dobj controlled:Phosphorylationt?e1: trigger-arg-path: leads:Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] controlled:PhosphorylationtAe1: trigger-arg-path: Positive_regulation >xcomp >dobj controlledt#interceding-token ngrams: serines 8t'interceding-token ngrams: sites furthert interceding-token ngrams: Greskot&e1: args2Role-mention-ngram: and leadstSe1: trigger-arg-path: leads >nsubj [lemma='damage'] controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=lead >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] Phosphorylationtqe1: trigger-arg-path: Positive_regulation >xcomp [lemma='direct'] >dobj [lemma='phosphorylation'] Phosphorylationt'e1: ents2Label-mention-ngram: to directtXe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation >xcomp >dobj controlledt*interceding-token ngrams: These N-terminalt#interceding-token ngrams: and 38 ast'e1: ents2Label-mention-ngram: and leadst$interceding-token ngrams: at serinestLe1: trigger-arg-path: leads:Positive_regulation >xcomp >dobj Phosphorylationt interceding-token ngrams: and 38t/interceding-token ngrams: sites further enhancetge1: trigger-arg-path: leads:Positive_regulation >nsubj [lemma='damage'] controller:Gene_or_gene_productt-interceding-token ngrams: vitro kinase assaystOe1: trigger-arg-path: lemmatizedTrigger=lead >nsubj [lemma='damage'] controllert*e1: args2Role-mention-ngram: induces HIPK2t3e1: trigger-arg-path: leads >xcomp >dobj controlledt,e1: args2Role-mention-ngram: leads to directt'interceding-token ngrams: Gresko et al.the2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='activity'] >nn [lemma='p53'] controlledt interceding-token ngrams: p53 istRe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='htt'] controllert&interceding-token ngrams: and in mousetle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='htt'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='htt'] Gene_or_gene_producttte2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt!e1: args2Role-mention-ngram: TP53t%e1: args2Role-mention-ngram: ( TP53 )t)interceding-token ngrams: mouse models oft)e1: args2Role-mention-ngram: THEME ( TP53tde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='htt'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: ( TP53 )tQe1: trigger-arg-path: interacts:Binding >nsubj [lemma='p53'] Gene_or_gene_productt"interceding-token ngrams: HD braintSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p53'] themetae2: trigger-arg-path: upregulates >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttSe1: trigger-arg-path: interacts >prep_with [lemma='htt'] theme:Gene_or_gene_productt>e1: trigger-arg-path: interacts >prep_with [lemma='htt'] themet%interceding-token ngrams: in HD braint:e1: trigger-arg-path: interacts >nsubj [lemma='p53'] themet?e2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='htt'] themetUe2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='htt'] controllert.e1: ents2Label-mention-ngram: TP53 ) interactst#e1: args2Role-mention-ngram: ( TP53tKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p53'] themetUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='htt'] Gene_or_gene_producttinterceding-token ngrams: braintinterceding-token ngrams: in HDt\e2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='htt'] Gene_or_gene_productt_e2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='htt'] Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation >nsubj [lemma='htt'] controller:Gene_or_gene_producttinterceding-token ngrams: , p53the1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p53'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: TP53 )t#interceding-token ngrams: models oftIe1: trigger-arg-path: interacts >nsubj [lemma='p53'] Gene_or_gene_productt"interceding-token ngrams: elevatedt+interceding-token ngrams: Furthermore , p53t`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p53'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='htt'] controllertWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='p53'] theme:Gene_or_gene_producttje2: trigger-arg-path: upregulates:Positive_activation >nsubj [lemma='htt'] controller:Gene_or_gene_producttEe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upregulates SHAREDtIe2: trigger-arg-path: Positive_activation >nsubj [lemma='htt'] controllertpe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='htt'] Gene_or_gene_productt)interceding-token ngrams: p53 is elevatedtKe1: trigger-arg-path: Binding >prep_with [lemma='htt'] Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLER upregulatestke2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt(interceding-token ngrams: of the diseasetBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='p53'] themet&interceding-token ngrams: HD brain andt%interceding-token ngrams: is elevatedt#interceding-token ngrams: disease ,t-e1: args2Role-mention-ngram: TP53 ) interactstle2: trigger-arg-path: upregulates >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt(interceding-token ngrams: elevated in HDt interceding-token ngrams: modelst'interceding-token ngrams: models of thet#e1: args2Role-mention-ngram: TP53 )tWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='htt'] themet?e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt,interceding-token ngrams: vivo . FurthermoretWe2: trigger-arg-path: upregulates >dobj [lemma='activity'] >nn [lemma='p53'] controlledtOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='htt'] themet"e1: ents2Label-mention-ngram: TP53t%interceding-token ngrams: elevated int}e2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='p53'] theme:Gene_or_gene_productt"interceding-token ngrams: , p53 ist&interceding-token ngrams: mouse modelstMe1: trigger-arg-path: interacts >prep_with [lemma='htt'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_activation >nsubj [lemma='htt'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='htt'] controller:Gene_or_gene_productt(interceding-token ngrams: is elevated int_e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt8e1: trigger-arg-path: Binding >nsubj [lemma='p53'] themet)interceding-token ngrams: in mouse modelstKe2: trigger-arg-path: upregulates >nsubj [lemma='htt'] Gene_or_gene_productt?interceding-tokens-full-span: in vitro and in vivo . Furthermore , p53 is elevated in HD brain and in mouse models of the disease , mutanttOe1: trigger-arg-path: interacts >nsubj [lemma='p53'] theme:Gene_or_gene_productt"interceding-token ngrams: , mutanttprep_with [lemma='htt'] themetinterceding-token ngrams: HDt+e1: ents2Label-mention-ngram: SHARED ( TP53tbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='p53'] Gene_or_gene_productt>e2: args2Role-mention-ngram: CONTROLLER upregulates CONTROLLEDt&interceding-token ngrams: brain and int!interceding-token ngrams: diseaset{e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='htt'] controller:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_with [lemma='htt'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='htt'] Gene_or_gene_productt[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='htt'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='p53'] Gene_or_gene_producttue2: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt#interceding-token ngrams: brain andt*interceding-token ngrams: disease , mutantt&CSSPATH: ROOT >ccomp ++ ROOT >conj_andtAe2: trigger-arg-path: upregulates >nsubj [lemma='htt'] controllertVe2: trigger-arg-path: upregulates >nsubj [lemma='htt'] controller:Gene_or_gene_productt'interceding-token ngrams: the disease ,tie2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upregulatest%interceding-token ngrams: the diseaset$e1: ents2Label-mention-ngram: ( TP53tGe1: trigger-arg-path: Binding >nsubj [lemma='p53'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: BAD and throught3e2: trigger-arg-path: upregulated >nsubj controllert%interceding-token ngrams: cytokines ,t!interceding-token ngrams: T cellst(interceding-token ngrams: uptake , whichtJe2: trigger-arg-path: Positive_activation >dobj [lemma='bcl-2'] controlledt%interceding-token ngrams: the absencet(e1: args2Role-mention-ngram: protein BADt?interceding-tokens-full-span: uptake , which is necessary to maintain T-cell viability . IL-7 protected human CD4 effector and memory T cells from apoptosis induced through the absence of stimulation and cytokines , andtge2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='il-7'] controllert]e2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='il-7'] Gene_or_gene_producttRe2: trigger-arg-path: upregulated:Positive_activation >dobj [lemma='bcl-2'] Familytae1: trigger-arg-path: phosphorylation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controllertinterceding-token ngrams: Tt(interceding-token ngrams: the absence oft-e1: ents2Label-mention-ngram: protein BAD andtSe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='il-7'] controllert/interceding-token ngrams: necessary to maintaint)interceding-token ngrams: is necessary tot)interceding-token ngrams: maintain T-cellt&interceding-token ngrams: necessary tot`e2: trigger-arg-path: upregulated:Positive_activation >nsubj [lemma='il-7'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn Simple_chemicalt#interceding-token ngrams: protectedtBe1: trigger-arg-path: Positive_regulation >conj_and >nn controllert&interceding-token ngrams: is necessaryt-interceding-token ngrams: through the absencet e1: args2Role-mention-ngram: BADtinterceding-token ngrams: IL-7t%interceding-token ngrams: to maintaintge2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='bcl-2'] controlledt.interceding-token ngrams: IL-7 protected humant)interceding-token ngrams: stimulation andtOe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='bcl-2'] Familyt&interceding-token ngrams: CD4 effectortGe1: trigger-arg-path: Positive_regulation >conj_and >nn Simple_chemicaltZe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='bcl-2'] controlled:Familyt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn controller:Simple_chemicalt(interceding-token ngrams: from apoptosist0interceding-token ngrams: from apoptosis inducedt interceding-token ngrams: . IL-7tSe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='bcl-2'] controlledtIe2: trigger-arg-path: upregulated >dobj [lemma='bcl-2'] controlled:Familytinterceding-token ngrams: CD4t>e2: trigger-arg-path: upregulated >dobj [lemma='bcl-2'] Familyt5e1: ents2Label-mention-ngram: through SIMPLE_CHEMICALt*interceding-token ngrams: viability . IL-7tFe2: trigger-arg-path: Positive_activation >dobj [lemma='bcl-2'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicaltQe2: trigger-arg-path: Positive_activation >dobj [lemma='bcl-2'] controlled:Familyt\e2: trigger-arg-path: upregulated:Positive_activation >nsubj controller:Gene_or_gene_producttze1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt,interceding-token ngrams: which is necessaryt#interceding-token ngrams: cytokinest$interceding-token ngrams: cells fromtRe1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn controllertQe2: trigger-arg-path: upregulated:Positive_activation >nsubj Gene_or_gene_productt-e1: ents2Label-mention-ngram: inactivation oftBe2: trigger-arg-path: upregulated >dobj [lemma='bcl-2'] controlledt*interceding-token ngrams: T-cell viabilitytGe2: trigger-arg-path: upregulated:Positive_activation >nsubj controllert"interceding-token ngrams: maintaintPe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn controllert=e2: trigger-arg-path: upregulated >nsubj Gene_or_gene_productt9e1: ents2Label-mention-ngram: SHARED proapoptotic proteintJe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj controlled:Familyt&interceding-token ngrams: effector andt interceding-token ngrams: T-celltee1: trigger-arg-path: Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controllert+interceding-token ngrams: apoptosis inducedt>e1: ents2Label-mention-ngram: phosphorylation and inactivationt?e2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj FamilytBe2: trigger-arg-path: upregulated >nsubj [lemma='il-7'] controllert"interceding-token ngrams: memory Tt6e1: ents2Label-mention-ngram: proapoptotic protein BADte2: trigger: upregulatedt,interceding-token ngrams: of stimulation andtqe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='il-7'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj controlledt-interceding-token ngrams: induced through thet,interceding-token ngrams: human CD4 effectort.e2: trigger-arg-path: upregulated >dobj Familyt3interceding-token ngrams: stimulation and cytokinest"interceding-token ngrams: effectort(interceding-token ngrams: IL-7 protectedt%interceding-token ngrams: viability .t&interceding-token ngrams: and memory Tt5e1: ents2Label-mention-ngram: the SHARED proapoptotict3e2: args2Role-mention-ngram: CONTROLLER upregulatedt interceding-token ngrams: uptaket0interceding-token ngrams: absence of stimulationt]e2: trigger-arg-path: upregulated:Positive_activation >dobj [lemma='bcl-2'] controlled:Familytie1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn Simple_chemicalt/e1: args2Role-mention-ngram: through CONTROLLERt3e2: args2Role-mention-ngram: upregulated CONTROLLEDtje1: trigger-arg-path: Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt&interceding-token ngrams: T cells fromt5e1: args2Role-mention-ngram: proapoptotic protein BADt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controller:Simple_chemicalt1e1: ents2Label-mention-ngram: SHARED proapoptotict9e2: trigger-arg-path: upregulated >dobj controlled:Familyt$interceding-token ngrams: and memoryt,e1: args2Role-mention-ngram: BAD and throught(interceding-token ngrams: memory T cellstWe2: trigger-arg-path: upregulated >nsubj [lemma='il-7'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controllert4e1: args2Role-mention-ngram: CONTROLLED proapoptotict2e1: ents2Label-mention-ngram: proapoptotic proteintLe2: trigger-arg-path: upregulated >nsubj [lemma='il-7'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: inactivation of thet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controllert!e1: ents2Label-mention-ngram: BADt(interceding-token ngrams: of stimulationt interceding-token ngrams: memoryt-interceding-token ngrams: effector and memoryt*interceding-token ngrams: CD4 effector andtCe2: trigger-arg-path: lemmatizedTrigger=upregulate >dobj controlledt"interceding-token ngrams: uptake ,t,interceding-token ngrams: to maintain T-cellt|e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >nsubj [lemma='il-7'] controller:Gene_or_gene_productt#interceding-token ngrams: human CD4t1e1: ents2Label-mention-ngram: and inactivation oft%e1: ents2Label-mention-ngram: throught#interceding-token ngrams: viabilityt$e1: args2Role-mention-ngram: throught_e2: trigger-arg-path: Positive_activation >nsubj [lemma='il-7'] controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj controlled:Familyt.interceding-token ngrams: cells from apoptosistfe1: trigger-arg-path: phosphorylation >conj_and [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt>e1: trigger-arg-path: phosphorylation >conj_and >nn controllert,interceding-token ngrams: T-cell viability .tNe1: trigger-arg-path: phosphorylation >conj_and >nn controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controller:Simple_chemicaltMe2: trigger-arg-path: upregulated:Positive_activation >dobj controlled:Familyt4CSSPATH: ROOT >ccomp >prep_through ++ ROOT >conj_andtte1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn controller:Simple_chemicaltCe1: trigger-arg-path: phosphorylation >conj_and >nn Simple_chemicaltde1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn controllert$interceding-token ngrams: absence oft-interceding-token ngrams: protected human CD4t(e2: args2Role-mention-ngram: upregulatedtke2: trigger-arg-path: upregulated:Positive_activation >nsubj [lemma='il-7'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: and throught'interceding-token ngrams: and cytokinest3interceding-token ngrams: maintain T-cell viabilityt1e1: args2Role-mention-ngram: proapoptotic proteintue1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controllert*e1: ents2Label-mention-ngram: inactivationt)interceding-token ngrams: and cytokines ,tce2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='bcl-2'] Familyt)interceding-token ngrams: cytokines , andt>e2: args2Role-mention-ngram: CONTROLLER upregulated CONTROLLEDt,e1: args2Role-mention-ngram: protein BAD andt$e1: args2Role-mention-ngram: BAD andtSe2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj Familyt)e1: ents2Label-mention-ngram: protein BADt!interceding-token ngrams: absencetconj_and [lemma='uptake'] >nn [lemma='glucose'] controller:Simple_chemicaltVe2: trigger-arg-path: upregulated:Positive_activation >nsubj [lemma='il-7'] controllertWe1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn Simple_chemicalt.e1: ents2Label-mention-ngram: and inactivationtRe1: trigger-arg-path: Positive_regulation >conj_and >nn controller:Simple_chemicalt3e1: args2Role-mention-ngram: and through CONTROLLERtue1: trigger-arg-path: Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controller:Simple_chemicaltJe2: trigger-arg-path: Positive_activation >nsubj [lemma='il-7'] controllert0e2: ents2Label-mention-ngram: upregulated SHAREDthe2: trigger-arg-path: lemmatizedTrigger=upregulate >nsubj [lemma='il-7'] controller:Gene_or_gene_productt)interceding-token ngrams: protected humantFe2: trigger-arg-path: upregulated:Positive_activation >dobj controlledt9e1: ents2Label-mention-ngram: and through SIMPLE_CHEMICALtTe2: trigger-arg-path: Positive_activation >nsubj [lemma='il-7'] Gene_or_gene_productt*interceding-token ngrams: . IL-7 protectedt?e1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='uptake'] >nn [lemma='glucose'] controller:Simple_chemicaltBe2: trigger-arg-path: upregulated:Positive_activation >dobj Familytbe1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn controller:Simple_chemicalt)interceding-token ngrams: induced throughtne2: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='bcl-2'] controlled:Familyt(e1: args2Role-mention-ngram: and throughtxe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='uptake'] >nn [lemma='glucose'] Simple_chemicalt3interceding-token ngrams: apoptosis induced throught2e2: trigger-arg-path: upregulated >dobj controlledt%e1: ents2Label-mention-ngram: BAD andtVe2: trigger-arg-path: upregulated:Positive_activation >dobj [lemma='bcl-2'] controlledtHe2: trigger-arg-path: upregulated >nsubj controller:Gene_or_gene_productt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upregulatedt#interceding-token ngrams: necessarytEe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT upregulated SHAREDtee2: trigger-arg-path: Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controllert%interceding-token ngrams: obtained byt#interceding-token ngrams: deficienttPe2: trigger-arg-path: lemmatizedTrigger=induce >prep_by >nn Gene_or_gene_productt(interceding-token ngrams: RSK2 deficientt~e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controllertinterceding-token ngrams: hist!interceding-token ngrams: RSK2 -/t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controller:Gene_or_gene_productt$interceding-token ngrams: by Cho andte2: trigger-arg-path: lemmatizedTrigger=induce >prep_by [lemma='stimulation'] >nn [lemma='egf'] controller:Gene_or_gene_productt%interceding-token ngrams: Cho and histinterceding-token ngrams: CLSt interceding-token ngrams: by EGFtFCSSPATH: ROOT >nsubj >rcmod ++ ROOT >ccomp >nsubjpass >dep >dep >rcmodt*interceding-token ngrams: of the wild-typet+interceding-token ngrams: Similar result istIe2: trigger-arg-path: induced:Positive_regulation >prep_by >nn controllertSe2: trigger-arg-path: induced:Positive_regulation >prep_by >nn Gene_or_gene_productt#interceding-token ngrams: . Similart[e2: trigger-arg-path: lemmatizedTrigger=induce >prep_by >nn controller:Gene_or_gene_productt#interceding-token ngrams: RSK2 -/ -tJe2: trigger-arg-path: induced >prep_by >nn controller:Gene_or_gene_productt interceding-token ngrams: mimicstYe2: trigger-arg-path: induced >prep_by [lemma='stimulation'] >nn [lemma='egf'] controllert4interceding-token ngrams: histone H3 phosphorylationt&interceding-token ngrams: that RSK2 -/tme2: trigger-arg-path: induced:Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controllertinterceding-tokens-full-span: 10 by EGF stimulation , and re-introduction of the wild-type RSK2 to RSK2 deficient CLS patient cells restores EGF induced histone H3 phosphorylation at serine 10 . Similar result is obtained by Cho and his colleagues that RSK2 -/ - MEFs mimicst-interceding-token ngrams: his colleagues thatt?e2: trigger-arg-path: induced:Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controller:Gene_or_gene_productt,interceding-token ngrams: cells restores EGFt%interceding-token ngrams: is obtainedt&interceding-token ngrams: 10 . Similart,interceding-token ngrams: H3 phosphorylationt!interceding-token ngrams: and hist*interceding-token ngrams: . Similar resulttZe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by >nn controllert/interceding-token ngrams: deficient CLS patienttze2: trigger-arg-path: Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] controller:Gene_or_gene_productt)interceding-token ngrams: obtained by Chot=e2: ents2Label-mention-ngram: induced by GENE_OR_GENE_PRODUCTt!interceding-token ngrams: to RSK2tinterceding-token ngrams: H3t3interceding-token ngrams: phosphorylation at serinet!interceding-token ngrams: patienttprep_by [lemma='stimulation'] >nn [lemma='egf'] Gene_or_gene_productt,interceding-token ngrams: result is obtainedt0interceding-token ngrams: patient cells restorest*e2: args2Role-mention-ngram: 10 induced byt/interceding-token ngrams: , and re-introductiont#interceding-token ngrams: serine 10tinterceding-token ngrams: Chot+interceding-token ngrams: CLS patient cellst%interceding-token ngrams: serine 10 .toe2: trigger-arg-path: Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=induce >prep_by >nn controllert,interceding-token ngrams: and his colleaguest+interceding-token ngrams: wild-type RSK2 totBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT deficient humant&interceding-token ngrams: restores EGFt$interceding-token ngrams: colleaguestne2: trigger-arg-path: induced >prep_by [lemma='stimulation'] >nn [lemma='egf'] controller:Gene_or_gene_producttinterceding-token ngrams: 10 .t)interceding-token ngrams: re-introductiontte2: trigger-arg-path: lemmatizedTrigger=induce >prep_by [lemma='stimulation'] >nn [lemma='egf'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=induce >prep_by [lemma='stimulation'] >nn [lemma='egf'] controllert/e2: ents2Label-mention-ngram: serine 10 inducedt,interceding-token ngrams: RSK2 deficient CLSt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by [lemma='stimulation'] >nn [lemma='egf'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: 10 induced byt%interceding-token ngrams: MEFs mimicstKe2: trigger-arg-path: Positive_regulation >prep_by >nn Gene_or_gene_producttVe2: trigger-arg-path: Positive_regulation >prep_by >nn controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: induced by CONTROLLERt+interceding-token ngrams: stimulation , andt,interceding-token ngrams: by EGF stimulationt!interceding-token ngrams: Cho andt?e2: trigger-arg-path: induced >prep_by >nn Gene_or_gene_productt*e2: args2Role-mention-ngram: CONTROLLED 10t,interceding-token ngrams: re-introduction oftce2: trigger-arg-path: induced >prep_by [lemma='stimulation'] >nn [lemma='egf'] Gene_or_gene_productt^e2: trigger-arg-path: induced:Positive_regulation >prep_by >nn controller:Gene_or_gene_productt(interceding-token ngrams: his colleaguest)interceding-token ngrams: induced histonetoe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by >nn controller:Gene_or_gene_productt'interceding-token ngrams: patient cellst2e2: args2Role-mention-ngram: CONTROLLED 10 inducedt%interceding-token ngrams: CLS patientt+interceding-token ngrams: to RSK2 deficientt0interceding-token ngrams: re-introduction of thet#interceding-token ngrams: result ist)interceding-token ngrams: colleagues thatt!interceding-token ngrams: RSK2 tot'interceding-token ngrams: - MEFs mimicst.interceding-token ngrams: restores EGF inducedtinterceding-token ngrams: 10 bytinterceding-token ngrams: RSK2t-interceding-token ngrams: and re-introductiontinterceding-token ngrams: 10t!interceding-token ngrams: Similart/interceding-token ngrams: H3 phosphorylation att'e2: args2Role-mention-ngram: 10 inducedt"interceding-token ngrams: restorest(interceding-token ngrams: Similar resultt(interceding-token ngrams: cells restorest-interceding-token ngrams: EGF induced histonet5e2: trigger-arg-path: induced >prep_by >nn controllert,interceding-token ngrams: the wild-type RSK2t(interceding-token ngrams: is obtained byt+interceding-token ngrams: EGF stimulation ,t'interceding-token ngrams: deficient CLSt&interceding-token ngrams: at serine 10t$interceding-token ngrams: histone H3t.interceding-token ngrams: colleagues that RSK2t interceding-token ngrams: by Chotde2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >prep_by >nn Gene_or_gene_productt(e2: ents2Label-mention-ngram: 10 inducedt,interceding-token ngrams: induced histone H3t#interceding-token ngrams: that RSK2tAe2: trigger-arg-path: Positive_regulation >prep_by >nn controllert0interceding-token ngrams: and re-introduction oft&interceding-token ngrams: RSK2 to RSK2t%interceding-token ngrams: EGF inducedt#interceding-token ngrams: at serinet#interceding-token ngrams: 10 by EGFt\e1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt:e1: trigger-arg-path: promoted >nsubj Gene_or_gene_productt]e2: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttge1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] controller:Gene_or_gene_producttYe1: trigger-arg-path: promoted:Positive_regulation >nsubj controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] controllertxe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt;e1: args2Role-mention-ngram: CONTROLLER promoted CONTROLLEDtqe2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] Gene_or_gene_productt-interceding-token ngrams: these data stronglyt/interceding-token ngrams: data strongly suggestt>e1: trigger-arg-path: promoted >nsubj [lemma='erk'] controllertSe1: trigger-arg-path: promoted >nsubj [lemma='erk'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn controllertHe2: trigger-arg-path: promotes:Positive_regulation >nsubj >nn controllertKinterceding-tokens-full-span: . Together , these data strongly suggest thattEe1: trigger-arg-path: promoted >nsubj controller:Gene_or_gene_productt7e2: args2Role-mention-ngram: CONTROLLER kinase promotest0e1: args2Role-mention-ngram: promoted CONTROLLEDt/interceding-token ngrams: strongly suggest thatt"interceding-token ngrams: stronglytOe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] controllert4e2: ents2Label-mention-ngram: SHARED kinase promotestYe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='erk'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] controller:Gene_or_gene_producttDe1: trigger-arg-path: promoted:Positive_regulation >nsubj controllert0e1: args2Role-mention-ngram: CONTROLLER promotedt|e2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttRe2: trigger-arg-path: promotes:Positive_regulation >nsubj >nn Gene_or_gene_productt]e2: trigger-arg-path: promotes:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt'interceding-token ngrams: data stronglytye2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='kinase'] >nn [lemma='erk'] controllertNe1: trigger-arg-path: promoted:Positive_regulation >nsubj Gene_or_gene_productt:e1: ents2Label-mention-ngram: promoted poly-ubiquitinationtme1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='erk'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: promoted poly-ubiquitination oft-e1: ents2Label-mention-ngram: SHARED promotedtAe1: ents2Label-mention-ngram: SHARED promoted poly-ubiquitinationt*interceding-token ngrams: strongly suggestt4e2: ents2Label-mention-ngram: kinase promotes SHAREDtge2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert-e2: ents2Label-mention-ngram: kinase promotest0e1: trigger-arg-path: promoted >nsubj controllertRe1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='erk'] controllertHe1: trigger-arg-path: promoted >nsubj [lemma='erk'] Gene_or_gene_productt7e2: args2Role-mention-ngram: kinase promotes CONTROLLEDthe2: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: kinase promotestSe2: trigger-arg-path: promotes >nsubj [lemma='kinase'] >nn [lemma='erk'] controllert5interceding-token ngrams: by phosphoinosite dependentt/e1: args2Role-mention-ngram: THEME can interactt(interceding-token ngrams: To develop itst"e2: args2Role-mention-ngram: 473 ,t"interceding-token ngrams: PDK1 ) .tMe1: trigger-arg-path: interact >prep_with [lemma='pip3'] Gene_or_gene_productt#e2: args2Role-mention-ngram: secondt#e2: ents2Label-mention-ngram: 473 ,t)e2: ents2Label-mention-ngram: at a secondt!e2: args2Role-mention-ngram: , byt(interceding-token ngrams: phosphoinositetNe1: trigger-arg-path: interact >nsubj [lemma='AKT'] theme:Gene_or_gene_productt7interceding-token ngrams: Threonin308 by phosphoinositet(interceding-token ngrams: Threonin308 byt(e2: args2Role-mention-ngram: at a secondt+interceding-token ngrams: at Threonin308 byt)e2: args2Role-mention-ngram: , Serine 473t*e2: ents2Label-mention-ngram: Serine 473 ,t interceding-token ngrams: AKT att>e1: trigger-arg-path: interact >prep_with [lemma='pip3'] themet.e1: args2Role-mention-ngram: can interact witht.e2: args2Role-mention-ngram: second amino acidtLe1: trigger-arg-path: Binding >prep_with [lemma='pip3'] Gene_or_gene_productt&interceding-token ngrams: . To developt%interceding-token ngrams: develop itstee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pip3'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='AKT'] Gene_or_gene_productt"interceding-token ngrams: ( PDK1 )t#e2: args2Role-mention-ngram: Serinet(interceding-token ngrams: at Threonin308t'interceding-token ngrams: followed by at#e2: args2Role-mention-ngram: acid ,t*e2: args2Role-mention-ngram: acid , SerinetSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='AKT'] themet)e1: args2Role-mention-ngram: can interactt"e2: args2Role-mention-ngram: aminot*e2: ents2Label-mention-ngram: second aminotinterceding-token ngrams: PDK1t1e1: ents2Label-mention-ngram: SHARED can interactt,e2: ents2Label-mention-ngram: a second aminot e2: args2Role-mention-ngram: 473t2interceding-token ngrams: phosphoinosite dependenttZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='AKT'] Gene_or_gene_producttHe1: trigger-arg-path: interact >nsubj [lemma='AKT'] Gene_or_gene_productt$interceding-token ngrams: To developt+e2: args2Role-mention-ngram: a second aminot*e2: ents2Label-mention-ngram: amino acid ,t*e2: args2Role-mention-ngram: CONTROLLED att:interceding-token ngrams: phosphoinosite dependent proteint"e2: ents2Label-mention-ngram: , byt"e2: ents2Label-mention-ngram: acidt#e2: ents2Label-mention-ngram: aminotKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='AKT'] themet?interceding-tokens-full-span: , followed by a phosphorylation of AKT at Threonin308 by phosphoinosite dependent protein kinase-1 ( PDK1 ) . To develop its full activity ,t interceding-token ngrams: ( PDK1tSe1: trigger-arg-path: interact >prep_with [lemma='pip3'] theme:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='AKT'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: acid , Serinet%e2: args2Role-mention-ngram: , by thet%e2: args2Role-mention-ngram: , Serinet.interceding-token ngrams: by a phosphorylationtge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pip3'] Gene_or_gene_productt)e2: args2Role-mention-ngram: Serine 473 ,tGe1: trigger-arg-path: Binding >nsubj [lemma='AKT'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: phosphorylated att%e2: args2Role-mention-ngram: 473 , byt%e2: args2Role-mention-ngram: a secondt"interceding-token ngrams: kinase-1t$interceding-token ngrams: , followedt)interceding-token ngrams: full activity ,t,interceding-token ngrams: AKT at Threonin308t,interceding-token ngrams: protein kinase-1 (t1e2: ents2Label-mention-ngram: phosphorylated at at`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='AKT'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: second aminot+interceding-token ngrams: its full activityt%interceding-token ngrams: followed bytRe1: trigger-arg-path: Binding >prep_with [lemma='pip3'] theme:Gene_or_gene_productt interceding-token ngrams: of AKTt(e2: ents2Label-mention-ngram: amino acidt/e2: ents2Label-mention-ngram: second amino acidtFe1: trigger-arg-path: interact:Binding >prep_with [lemma='pip3'] themet4interceding-token ngrams: dependent protein kinase-1t&e2: ents2Label-mention-ngram: , by thet'e2: args2Role-mention-ngram: amino acidtVe1: trigger-arg-path: interact:Binding >nsubj [lemma='AKT'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: can interact witht9e1: trigger-arg-path: interact >nsubj [lemma='AKT'] themet&e2: ents2Label-mention-ngram: , Serinet(e2: ents2Label-mention-ngram: Serine 473t&e2: ents2Label-mention-ngram: 473 , byt"interceding-token ngrams: followedt+interceding-token ngrams: by phosphoinositet&e2: ents2Label-mention-ngram: a secondt$interceding-token ngrams: kinase-1 (t.interceding-token ngrams: a phosphorylation oft0interceding-token ngrams: phosphorylation of AKTt interceding-token ngrams: PDK1 )t'e2: args2Role-mention-ngram: Serine 473t%interceding-token ngrams: Threonin308t=e1: trigger-arg-path: Binding >prep_with [lemma='pip3'] themetAe1: trigger-arg-path: interact:Binding >nsubj [lemma='AKT'] themetUe1: trigger-arg-path: interact:Binding >prep_with [lemma='pip3'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: can interactt,e2: args2Role-mention-ngram: CONTROLLED at at$e2: ents2Label-mention-ngram: secondt)e2: args2Role-mention-ngram: amino acid ,t!e2: args2Role-mention-ngram: at atme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pip3'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubj [lemma='AKT'] theme:Gene_or_gene_productt[e1: trigger-arg-path: interact:Binding >prep_with [lemma='pip3'] theme:Gene_or_gene_productt*interceding-token ngrams: develop its fullt"interceding-token ngrams: its fulltPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pip3'] themetPe1: trigger-arg-path: interact:Binding >nsubj [lemma='AKT'] Gene_or_gene_producttinterceding-token ngrams: by atXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pip3'] themet'interceding-token ngrams: , followed byt*e2: ents2Label-mention-ngram: , Serine 473t#interceding-token ngrams: of AKT att!interceding-token ngrams: developt8e1: trigger-arg-path: Binding >nsubj [lemma='AKT'] themet!e2: args2Role-mention-ngram: acidt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pip3'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: 473t'interceding-token ngrams: full activityt interceding-token ngrams: ) . Tot*interceding-token ngrams: protein kinase-1t$e2: ents2Label-mention-ngram: acid ,t$e2: ents2Label-mention-ngram: Serinet)interceding-token ngrams: kinase-1 ( PDK1t2e2: ents2Label-mention-ngram: is phosphorylated att,e1: ents2Label-mention-ngram: triggered botht$e1: ents2Label-mention-ngram: HCT116tRe1: trigger-arg-path: induced >nsubj [lemma='egf'] controller:Gene_or_gene_productt$interceding-token ngrams: fully taketinterceding-token ngrams: n'tt(interceding-token ngrams: does n't fullytinterceding-token ngrams: taket)interceding-token ngrams: over the ligandt&interceding-token ngrams: pretreatmentt.e1: args2Role-mention-ngram: cells and inducedt(interceding-token ngrams: mutant cells .t/e1: args2Role-mention-ngram: triggered both Aktt#interceding-token ngrams: with HDACt3e2: ents2Label-mention-ngram: stimulated SHARED andtQe1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] controllert*interceding-token ngrams: and also implingt0e1: ents2Label-mention-ngram: phosphorylation int-e1: args2Role-mention-ngram: HCT116 cells andt*interceding-token ngrams: the significancet+interceding-token ngrams: pretreatment witht-interceding-token ngrams: activation in SW480t3e1: ents2Label-mention-ngram: SHARED triggered botht!interceding-token ngrams: implingt0e1: ents2Label-mention-ngram: and induced SHAREDtGe1: trigger-arg-path: induced >nsubj [lemma='egf'] Gene_or_gene_productt%e1: args2Role-mention-ngram: both Aktt1e1: ents2Label-mention-ngram: ERK phosphorylationt.interceding-token ngrams: indicating that KRASt0e1: ents2Label-mention-ngram: triggered both Aktt4e1: args2Role-mention-ngram: and ERK phosphorylationtinterceding-token ngrams: , TSAt'e1: ents2Label-mention-ngram: cells andt(interceding-token ngrams: in SW480 cellst%interceding-token ngrams: impling thet+interceding-token ngrams: mutation does n'tt*interceding-token ngrams: cells . Moreovert6e2: ents2Label-mention-ngram: SHARED stimulated SHAREDt!interceding-token ngrams: EGFR int&interceding-token ngrams: also implingt(interceding-token ngrams: in KRAS mutantt.e1: ents2Label-mention-ngram: SHARED triggeredt#e1: args2Role-mention-ngram: HCT116t&e1: ents2Label-mention-ngram: both Aktt"interceding-token ngrams: does n'tt0interceding-token ngrams: pretreatment with HDACt-interceding-token ngrams: activation and alsot)e1: args2Role-mention-ngram: HCT116 cellst)interceding-token ngrams: , disrupted thet&interceding-token ngrams: TSA and SAHAt=e1: trigger-arg-path: induced >nsubj [lemma='egf'] controllertinterceding-token ngrams: fullyt.interceding-token ngrams: significance of EGFRt$interceding-token ngrams: and SAHA ,tinterceding-token ngrams: KRASt'interceding-token ngrams: take over thet)e1: args2Role-mention-ngram: both Akt andt%interceding-token ngrams: , disruptedt"interceding-token ngrams: over thet1e1: args2Role-mention-ngram: CONTROLLER triggeredt interceding-token ngrams: SAHA ,t1e2: ents2Label-mention-ngram: Akt phosphorylationt+interceding-token ngrams: KRAS mutant cellst)e1: ents2Label-mention-ngram: Akt and ERKt6e1: args2Role-mention-ngram: phosphorylation in HCT116t+interceding-token ngrams: HDAC inhibitors ,t,e1: args2Role-mention-ngram: in HCT116 cellstCe1: trigger-arg-path: induced:Positive_activation >nsubj controllertXe1: trigger-arg-path: induced:Positive_activation >nsubj controller:Gene_or_gene_productt-interceding-token ngrams: , pretreatment witht1interceding-token ngrams: Moreover , pretreatmentt/e1: ents2Label-mention-ngram: cells and inducedt)e1: ents2Label-mention-ngram: and inducedtUe1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='erk'] controlledt'interceding-token ngrams: KRAS mutationt0e1: args2Role-mention-ngram: ERK phosphorylationt$interceding-token ngrams: of EGFR int#interceding-token ngrams: take overt,interceding-token ngrams: that KRAS mutationt!interceding-token ngrams: TSA andt)interceding-token ngrams: ligand mediatedt%interceding-token ngrams: KRAS mutantt"interceding-token ngrams: in SW480t&e1: args2Role-mention-ngram: in HCT116t(interceding-token ngrams: , pretreatmentt-interceding-token ngrams: the ligand mediatedt'interceding-token ngrams: mutation doest%e1: ents2Label-mention-ngram: Akt andt,interceding-token ngrams: ERK activation andtinterceding-token ngrams: SAHAt"interceding-token ngrams: and SAHAt)interceding-token ngrams: significance oft$e1: args2Role-mention-ngram: Akt andt-interceding-token ngrams: the significance oft,e2: ents2Label-mention-ngram: SHARED and Aktt(e1: args2Role-mention-ngram: and inducedt%interceding-token ngrams: SW480 cellst(interceding-token ngrams: activation andt~e1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt.interceding-token ngrams: with HDAC inhibitorst#interceding-token ngrams: that KRASt#interceding-token ngrams: , TSA andt+e1: args2Role-mention-ngram: triggered botht(e1: args2Role-mention-ngram: Akt and ERKtje1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt(interceding-token ngrams: n't fully taket_e1: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt*interceding-token ngrams: SAHA , disruptedtinterceding-token ngrams: TSAt$interceding-token ngrams: the ligandt6e1: args2Role-mention-ngram: CONTROLLER triggered botht interceding-tokens-full-span: activation in SW480 cells , indicating that KRAS mutation does n't fully take over the ligand mediated ERK activation and also impling the significance of EGFR in KRAS mutant cells . Moreover , pretreatment with HDAC inhibitors , TSA and SAHA , disrupted thet,interceding-token ngrams: KRAS mutation doest[e1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] Gene_or_gene_productt'interceding-token ngrams: disrupted thet%e2: ents2Label-mention-ngram: and Aktt*interceding-token ngrams: inhibitors , TSAtse1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt3e1: args2Role-mention-ngram: and induced CONTROLLEDtMe1: trigger-arg-path: induced:Positive_activation >nsubj Gene_or_gene_productt2interceding-token ngrams: impling the significancet&interceding-token ngrams: EGFR in KRASt*e1: ents2Label-mention-ngram: HCT116 cellstfe1: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: in HCT116tie1: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt.e1: ents2Label-mention-ngram: HCT116 cells andt)interceding-token ngrams: HDAC inhibitorst*e1: ents2Label-mention-ngram: both Akt andt1interceding-token ngrams: mediated ERK activationt5e2: ents2Label-mention-ngram: and Akt phosphorylationt-interceding-token ngrams: ligand mediated ERKt&e1: args2Role-mention-ngram: cells andt!interceding-token ngrams: in KRASt interceding-token ngrams: ligandtinterceding-token ngrams: SW480t!interceding-token ngrams: of EGFRt/e1: args2Role-mention-ngram: phosphorylation int-e1: ents2Label-mention-ngram: in HCT116 cellst'interceding-token ngrams: SW480 cells ,t)interceding-token ngrams: fully take overt5e1: ents2Label-mention-ngram: and ERK phosphorylationt3e1: args2Role-mention-ngram: ERK phosphorylation int/e2: ents2Label-mention-ngram: stimulated SHAREDt&interceding-token ngrams: significancet7e1: ents2Label-mention-ngram: phosphorylation in HCT116t4e1: ents2Label-mention-ngram: ERK phosphorylation int#interceding-token ngrams: n't fullyt&interceding-token ngrams: mediated ERKt*interceding-token ngrams: also impling thet*interceding-token ngrams: occurs only upontHe2: trigger-arg-path: lemmatizedTrigger=activation >nn controller:FamilytQe1: trigger-arg-path: associates:Binding >nsubj [lemma='it'] theme:Generic_entitytAe2: trigger-arg-path: lemmatizedTrigger=activation >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] Gene_or_gene_productt>e1: trigger-arg-path: associates:Binding >nsubj Generic_entityt4e2: trigger-arg-path: Positive_activation >nn Familyt_e1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='mek'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=activation >rcmod >nsubj controlledt/e2: ents2Label-mention-ngram: activation SHAREDtQe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn Familytnsubj theme:Generic_entityt^e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='ra'] Familytbe2: trigger-arg-path: activation:Positive_activation >rcmod >nsubj controlled:Gene_or_gene_productt'interceding-token ngrams: 2 occurs onlytie2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='ra'] controller:FamilytJe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ra'] Familyt+interceding-token ngrams: , but interactiontse2: trigger-arg-path: lemmatizedTrigger=activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] Gene_or_gene_productt#interceding-token ngrams: only upont.interceding-token ngrams: but interaction withtFe1: ents2Label-mention-ngram: constitutively with GENE_OR_GENE_PRODUCTtSe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] themet?e2: trigger-arg-path: activation:Positive_activation >nn Familyt%interceding-token ngrams: Thus , upontTe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] Generic_entitytBe2: trigger-arg-path: Positive_activation >rcmod >nsubj controlledtprep_with [lemma='mek'] themetGe1: trigger-arg-path: associates:Binding >prep_with [lemma='mek'] themetae2: trigger-arg-path: activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] Gene_or_gene_productt,interceding-token ngrams: factor stimulationtKe1: trigger-arg-path: associates:Binding >nsubj [lemma='it'] Generic_entityt`e2: trigger-arg-path: lemmatizedTrigger=activation >rcmod >nsubj controlled:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] theme:Generic_entitytPe2: trigger-arg-path: activation:Positive_activation >nn [lemma='ra'] controllertOe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj Generic_entityt/e2: ents2Label-mention-ngram: FAMILY activationt;e1: args2Role-mention-ngram: associates constitutively witht$interceding-token ngrams: with C-Raftge1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='mek'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ra'] controllert(interceding-token ngrams: with C-Raf andt\e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] Generic_entityt8e2: trigger-arg-path: activation >nn [lemma='ra'] Familyt?e2: trigger-arg-path: activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlled:Gene_or_gene_producttAe2: trigger-arg-path: Positive_activation >nn [lemma='ra'] Familyt)interceding-token ngrams: but interactiont6e1: args2Role-mention-ngram: associates constitutivelytWe2: trigger-arg-path: Positive_activation >rcmod >nsubj controlled:Gene_or_gene_producttue2: trigger-arg-path: Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlled:Gene_or_gene_productt=e2: trigger-arg-path: lemmatizedTrigger=activation >nn FamilytWe2: trigger-arg-path: activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlled:Gene_or_gene_producttCe1: trigger-arg-path: associates >nsubj [lemma='it'] Generic_entityt(interceding-token ngrams: C-Raf and ERK1t,interceding-token ngrams: upon growth factortBe1: trigger-arg-path: associates:Binding >nsubj [lemma='it'] themet9e2: trigger-arg-path: activation >rcmod >nsubj controlledtme1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='mek'] theme:Gene_or_gene_productt%interceding-token ngrams: occurs onlyt%interceding-token ngrams: upon growthtje2: trigger-arg-path: Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] Gene_or_gene_productt0interceding-token ngrams: interaction with C-RaftPe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='mek'] themet=e2: args2Role-mention-ngram: CONTROLLER activation CONTROLLEDtMe2: trigger-arg-path: activation:Positive_activation >rcmod >nsubj controlledt?e1: trigger-arg-path: associates >prep_with [lemma='mek'] themet$interceding-token ngrams: ERK1 and 2t6e1: trigger-arg-path: associates >nsubj Generic_entitytWe2: trigger-arg-path: activation:Positive_activation >rcmod >nsubj Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='ra'] controllertNe2: trigger-arg-path: activation >rcmod >nsubj controlled:Gene_or_gene_productt6e2: trigger-arg-path: activation >nn controller:Familyt>e1: ents2Label-mention-ngram: SHARED associates constitutivelyt/e2: trigger-arg-path: activation >nn controllertLe2: trigger-arg-path: Positive_activation >rcmod >nsubj Gene_or_gene_producttCe2: trigger-arg-path: activation >rcmod >nsubj Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >rcmod >nsubj controlled:Gene_or_gene_productt+e2: trigger-arg-path: activation >nn FamilytUe2: trigger-arg-path: lemmatizedTrigger=activation >rcmod >nsubj Gene_or_gene_productt2e2: args2Role-mention-ngram: activation CONTROLLEDt1e1: ents2Label-mention-ngram: constitutively withtUe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj theme:Generic_entitytQe1: trigger-arg-path: Binding >prep_with [lemma='mek'] theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: FAMILY activation SHAREDt`e2: trigger-arg-path: Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlledtTe1: trigger-arg-path: associates >prep_with [lemma='mek'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='mek'] theme:Gene_or_gene_productt.interceding-token ngrams: factor stimulation .t?interceding-tokens-full-span: , but interaction with C-Raf and ERK1 and 2 occurs only upon growth factor stimulation . Thus , upontVe1: trigger-arg-path: associates:Binding >prep_with [lemma='mek'] Gene_or_gene_producttCe2: trigger-arg-path: activation >nn [lemma='ra'] controller:FamilytIe1: trigger-arg-path: associates >nsubj [lemma='it'] theme:Generic_entitytWe2: trigger-arg-path: activation:Positive_activation >nn [lemma='ra'] controller:Familyt~e2: trigger-arg-path: lemmatizedTrigger=activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controllertie2: trigger-arg-path: lemmatizedTrigger=activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlledt?e2: trigger-arg-path: Positive_activation >nn controller:FamilytMe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj theme:Generic_entityt'interceding-token ngrams: stimulation .t\e1: trigger-arg-path: associates:Binding >prep_with [lemma='mek'] theme:Gene_or_gene_producttue2: trigger-arg-path: activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] Gene_or_gene_productt6e1: args2Role-mention-ngram: constitutively with THEMEtCe2: trigger-arg-path: activation:Positive_activation >nn controllert"interceding-token ngrams: 2 occurstKe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='it'] themetprep_with [lemma='mek'] Gene_or_gene_productt*interceding-token ngrams: only upon growthtGe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj Generic_entitytDe1: trigger-arg-path: associates:Binding >nsubj theme:Generic_entitytKe1: trigger-arg-path: Binding >prep_with [lemma='mek'] Gene_or_gene_productt,interceding-token ngrams: stimulation . ThustLe2: trigger-arg-path: Positive_activation >nn [lemma='ra'] controller:Familyt_e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >rcmod >nsubj controlledt interceding-token ngrams: , upont"interceding-token ngrams: ERK1 andt&interceding-token ngrams: and 2 occurst+CSSPATH: ROOT >parataxis ++ ROOT >prep_upont7e1: ents2Label-mention-ngram: associates constitutivelytle2: trigger-arg-path: activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ra'] controller:Familytrcmod >nsubj Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn controller:Familyt0e1: args2Role-mention-ngram: constitutively witht3interceding-token ngrams: growth factor stimulationtLe2: trigger-arg-path: activation:Positive_activation >nn [lemma='ra'] Familyt}e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlledtXe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='mek'] themetEe2: trigger-arg-path: Positive_activation >nn [lemma='ra'] controllert:e1: trigger-arg-path: associates >nsubj [lemma='it'] themetnn [lemma='ra'] controllert&interceding-token ngrams: and ERK1 andtJe2: trigger-arg-path: activation:Positive_activation >nn controller:Familytbe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='it'] theme:Generic_entitytke2: trigger-arg-path: activation:Positive_activation >rcmod [lemma='bring'] >nsubj [lemma='KSR'] controlledt$interceding-token ngrams: capacity .t'interceding-token ngrams: capacity . Ast1e2: args2Role-mention-ngram: by active CONTROLLERtinterceding-token ngrams: abletse1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='phosphorylation'] PhosphorylationtPe2: trigger-arg-path: Negative_activation >agent controller:Gene_or_gene_productt,interceding-token ngrams: as a pro-apoptotictPe2: trigger-arg-path: lemmatizedTrigger=repress nsubj [lemma='p53'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation dobj controlled:Phosphorylationtce1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >nsubj [lemma='p53'] controllert2interceding-token ngrams: subsequently affects itst!interceding-token ngrams: may actt.e2: args2Role-mention-ngram: active CONTROLLERt4e1: ents2Label-mention-ngram: or increasing tyrosinet2e1: args2Role-mention-ngram: CONTROLLER , possiblyt+e1: args2Role-mention-ngram: JAK expressiont"interceding-token ngrams: result ,t)interceding-token ngrams: to increase thet$interceding-token ngrams: and Bcl-xlt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , possiblytWe2: trigger-arg-path: lemmatizedTrigger=repress agent [lemma='stat-1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: phosphatase activityt.e1: args2Role-mention-ngram: by repressing JAKt e1: args2Role-mention-ngram: JAKt0e1: args2Role-mention-ngram: activity , preventstYe1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj Phosphorylationt.e1: args2Role-mention-ngram: JAK expression ortme1: trigger-arg-path: prevents:Negative_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtMe2: trigger-arg-path: Negative_activation nsubj [lemma='p53'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj [lemma='phosphorylation'] controlledt2interceding-token ngrams: anti-apoptotic Bcl-2 andtae2: trigger-arg-path: Negative_activation >agent [lemma='stat-1'] controller:Gene_or_gene_producttSe1: trigger-arg-path: prevents >nsubj [lemma='p53'] controller:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='stat-1'] controller:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=repress >agent [lemma='stat-1'] controllert;e2: trigger-arg-path: repressed >agent Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='stat-1'] controllert1interceding-token ngrams: increase the expressiont.interceding-token ngrams: DNA binding capacitytEe2: trigger-arg-path: lemmatizedTrigger=repress agent [lemma='stat-1'] controller:Gene_or_gene_productt&interceding-token ngrams: this may actt(e1: ents2Label-mention-ngram: activity ,t9e2: ents2Label-mention-ngram: active GENE_OR_GENE_PRODUCTt.interceding-token ngrams: subsequently affectst%e2: args2Role-mention-ngram: that aret0e1: args2Role-mention-ngram: increasing tyrosinetLe2: trigger-arg-path: repressed >agent [lemma='stat-1'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: by activet,e1: ents2Label-mention-ngram: repressing JAKt:e1: args2Role-mention-ngram: tyrosine phosphatase activityt"interceding-token ngrams: Bcl-xl ,t?interceding-tokens-full-span: and subsequently affects its DNA binding capacity . As a result , this may act as a pro-apoptotic signal , since STAT-3 is able to increase the expression of anti-apoptotic Bcl-2 and Bcl-xl , the sametdobj [lemma='phosphorylation'] controlledt&e2: args2Role-mention-ngram: by activet*interceding-token ngrams: binding capacityt+e1: ents2Label-mention-ngram: expression ort0e2: args2Role-mention-ngram: repressed by activetEe2: trigger-arg-path: repressed:Negative_activation >agent controllertge1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='p53'] controller:Gene_or_gene_productt2interceding-token ngrams: and subsequently affectst%interceding-token ngrams: As a resultt)interceding-token ngrams: since STAT-3 ist interceding-token ngrams: Bcl-xltPe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj controlled:Phosphorylationt)e2: args2Role-mention-ngram: repressed bytRe2: trigger-arg-path: repressed dobj Phosphorylationt'interceding-token ngrams: result , thist+e1: ents2Label-mention-ngram: or increasingt'e1: args2Role-mention-ngram: activity ,tAe2: trigger-arg-path: lemmatizedTrigger=repress >agent controllert=e1: ents2Label-mention-ngram: increasing tyrosine phosphataset interceding-token ngrams: act astEe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj PhosphorylationtLe2: trigger-arg-path: Negative_activation >agent [lemma='stat-1'] controllertpe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent [lemma='stat-1'] Gene_or_gene_productt1interceding-token ngrams: of anti-apoptotic Bcl-2t(e1: ents2Label-mention-ngram: repressingt-e2: args2Role-mention-ngram: are repressed bytZe1: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='phosphorylation'] controlledt5e2: trigger-arg-path: repressed dobj [lemma='phosphorylation'] Phosphorylationtinterceding-token ngrams: acttOe1: trigger-arg-path: lemmatizedTrigger=prevent >nsubj [lemma='p53'] controllert;e2: trigger-arg-path: Negative_activation nsubj [lemma='p53'] Gene_or_gene_producttNe1: trigger-arg-path: prevents >dobj [lemma='phosphorylation'] Phosphorylationt\e1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='p53'] Gene_or_gene_productt+interceding-token ngrams: of anti-apoptotict"interceding-token ngrams: a resultt_e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent Gene_or_gene_producttKe1: ents2Label-mention-ngram: prevents GENE_OR_GENE_PRODUCT phosphorylationt7e1: ents2Label-mention-ngram: repressing JAK expressiontFe2: trigger-arg-path: repressed >agent controller:Gene_or_gene_producttBe2: trigger-arg-path: repressed >agent [lemma='stat-1'] controllert@e2: trigger-arg-path: repressed nsubj [lemma='p53'] Gene_or_gene_producttJe2: trigger-arg-path: Negative_activation nsubj [lemma='p53'] Gene_or_gene_producttOe2: trigger-arg-path: repressed:Negative_activation >agent Gene_or_gene_productt,interceding-token ngrams: binding capacity .t!interceding-token ngrams: is abletIe2: trigger-arg-path: repressed:Negative_activation agent controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: by repressing JAKt$interceding-token ngrams: , this mayt3e1: args2Role-mention-ngram: phosphatase activity ,tYe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation dobj [lemma='phosphorylation'] controlled:Phosphorylationt&interceding-token ngrams: Bcl-xl , thet(interceding-token ngrams: , since STAT-3t"interceding-token ngrams: act as atge2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation agent controllert1e2: trigger-arg-path: repressed >agent controllertHe1: trigger-arg-path: prevents:Negative_regulation >dobj PhosphorylationtEe2: trigger-arg-path: Negative_activation >agent Gene_or_gene_productt$interceding-token ngrams: is able totWe2: trigger-arg-path: repressed >agent [lemma='stat-1'] controller:Gene_or_gene_producttke2: trigger-arg-path: repressed:Negative_activation >agent [lemma='stat-1'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: , possibly byt/e1: ents2Label-mention-ngram: JAK expression ort$interceding-token ngrams: a result ,tdobj controlled:Phosphorylationte2: trigger: repressedt,e1: ents2Label-mention-ngram: JAK expressiontje2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >agent controller:Gene_or_gene_productt"interceding-token ngrams: capacitytYe1: trigger-arg-path: prevents >dobj [lemma='phosphorylation'] controlled:Phosphorylationt=e1-label: Negative_regulation + e2-label: Negative_activationtRe1: trigger-arg-path: prevents:Negative_regulation >nsubj [lemma='p53'] controllert;e1: ents2Label-mention-ngram: tyrosine phosphatase activityt*e1: args2Role-mention-ngram: expression ort interceding-token ngrams: signalt\e2: trigger-arg-path: lemmatizedTrigger=repress >agent [lemma='stat-1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: tyrosine phosphataset8CSSPATH: ROOT  ++ ROOT >advcl >xcomp >dobj >appos >rcmodt#interceding-token ngrams: Bcl-2 andt%interceding-token ngrams: affects itstEe2: trigger-arg-path: repressed:Negative_activation nsubj [lemma='p53'] controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation agent [lemma='stat-1'] controllert2e1: args2Role-mention-ngram: , prevents CONTROLLEDtGe2: trigger-arg-path: repressed dobj [lemma='phosphorylation'] controlledt`e2: trigger-arg-path: repressed:Negative_activation >agent [lemma='stat-1'] Gene_or_gene_productt5e1: args2Role-mention-ngram: expression or increasingt>e1: trigger-arg-path: prevents >nsubj [lemma='p53'] controllert.interceding-token ngrams: anti-apoptotic Bcl-2t[e2: trigger-arg-path: repressed:Negative_activation agent Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=prevent:Negative_regulation >dobj controlled:Phosphorylationtje1: trigger-arg-path: lemmatizedTrigger=prevent >dobj [lemma='phosphorylation'] controlled:PhosphorylationtAe2: trigger-arg-path: lemmatizedTrigger=repress nsubj [lemma='p53'] controller:Gene_or_gene_productt!interceding-token ngrams: able totIe1: trigger-arg-path: Negative_regulation >nsubj [lemma='p53'] controllert.interceding-token ngrams: pro-apoptotic signaltbe1: trigger-arg-path: prevents:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt1e1: ents2Label-mention-ngram: activity , preventst"interceding-token ngrams: signal ,t+e2: ents2Label-mention-ngram: are repressedt(e1: ents2Label-mention-ngram: increasingt&interceding-token ngrams: increase thet6e1: args2Role-mention-ngram: repressing JAK expressiont+e1: args2Role-mention-ngram: repressing JAKt,e2: args2Role-mention-ngram: CONTROLLED thatt*e2: ents2Label-mention-ngram: repressed byt0e2: ents2Label-mention-ngram: that are repressedt2e1: ents2Label-mention-ngram: phosphatase activityt(interceding-token ngrams: STAT-3 is ablet3e1: args2Role-mention-ngram: possibly by repressingt6interceding-token ngrams: expression of anti-apoptotict$interceding-token ngrams: may act ast1e1: ents2Label-mention-ngram: increasing tyrosinetQe2: trigger-arg-path: Negative_activation agent controllertVe2: trigger-arg-path: lemmatizedTrigger=repress >agent controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: by repressingt0interceding-token ngrams: pro-apoptotic signal ,t,e1: ents2Label-mention-ngram: activates XIAPt8e1: args2Role-mention-ngram: subsequently activates XIAPt3e1: trigger-arg-path: catalyze >dobj Ubiquitinationt1e1: args2Role-mention-ngram: 's ubiquitin proteint%e1: args2Role-mention-ngram: ligase (tHe2: trigger-arg-path: degradation >prep_of [lemma='survivin'] controlledt0e1: ents2Label-mention-ngram: protein isopeptidet>e1: trigger-arg-path: catalyze >dobj controlled:Ubiquitinationt*interceding-token ngrams: and XAF1 complextAe1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj controlledt?interceding-tokens-full-span: . Activation of HER2 and ERK was shown to reduce the formation of the XIAP and XAF1 complex , which catalysestje1: trigger-arg-path: catalyze:Positive_regulation nsubj [lemma='xaf1'] ComplextRe1: trigger-arg-path: catalyze:Positive_regulation >dobj controlled:UbiquitinationtHe1: trigger-arg-path: catalyze:Positive_regulation nsubj Complextke1: trigger-arg-path: catalyze:Positive_regulation >dobj [lemma='ubiquitination'] controlled:UbiquitinationtCe1: trigger-arg-path: catalyze:Positive_regulation >dobj controlledt&e1: ents2Label-mention-ngram: ligase (t\e1: trigger-arg-path: catalyze:Positive_regulation >dobj [lemma='ubiquitination'] controlledt#interceding-token ngrams: to reducet)e1: ents2Label-mention-ngram: activity totZe1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj Complext"e1: ents2Label-mention-ngram: E3 )t)e1: ents2Label-mention-ngram: to catalyzetle1: trigger-arg-path: Positive_regulation nsubj [lemma='xaf1'] controller:Complextke1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj [lemma='xaf1'] controllertSe1: trigger-arg-path: catalyze:Positive_regulation nsubj controller:ComplextICSSPATH: ROOT >conj_and >xcomp ++ ROOT >xcomp >dobj >prep_of >rcmod >dobjt/e1: ents2Label-mention-ngram: XIAP 's ubiquitint)interceding-token ngrams: . Activation oftse1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj [lemma='xaf1'] controller:Complext(e1: args2Role-mention-ngram: ligase ( E3t.e1: args2Role-mention-ngram: activates XIAP 'ste1: args2Role-mention-ngram: E3tinterceding-token ngrams: HER2tZe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='survivin'] controlledtinterceding-token ngrams: XAF1t,interceding-token ngrams: Activation of HER2t-e1: args2Role-mention-ngram: and subsequentlyt)interceding-token ngrams: which catalysest3e1: args2Role-mention-ngram: to catalyze CONTROLLEDtKe1: trigger-arg-path: catalyze:Positive_regulation nsubj controllertde2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='survivin'] Gene_or_gene_productt)interceding-token ngrams: shown to reducet e1: ents2Label-mention-ngram: E3tJe1: trigger-arg-path: Positive_regulation nsubj controller:Complext*e1: args2Role-mention-ngram: E3 ) activitytLe1: trigger-arg-path: catalyze >dobj [lemma='ubiquitination'] Ubiquitinationt1e1: ents2Label-mention-ngram: isopeptide ligase (tWe1: trigger-arg-path: catalyze >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt%e1: args2Role-mention-ngram: catalyzet&interceding-token ngrams: XAF1 complextprep_of [lemma='survivin'] Gene_or_gene_productt.e1: args2Role-mention-ngram: ubiquitin proteint interceding-token ngrams: reducetde1: trigger-arg-path: Positive_regulation nsubj [lemma='xaf1'] controllertxe2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='survivin'] Gene_or_gene_productt'interceding-token ngrams: Activation oft&e1: ents2Label-mention-ngram: catalyzet-e1: ents2Label-mention-ngram: catalyze SHAREDt(e1: args2Role-mention-ngram: activity tot"e1: ents2Label-mention-ngram: ( E3t"interceding-token ngrams: XIAP andt!interceding-token ngrams: of HER2t(e1: args2Role-mention-ngram: to catalyzet"interceding-token ngrams: the XIAPtUe1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj controlledt7e1: args2Role-mention-ngram: and subsequently activatest)e1: args2Role-mention-ngram: 's ubiquitint`e1: trigger-arg-path: catalyze:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt!e1: args2Role-mention-ngram: XIAPtHe1: trigger-arg-path: catalyze >dobj [lemma='ubiquitination'] controlledt%interceding-token ngrams: of the XIAPtde1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj controlled:UbiquitinationtRe2: trigger-arg-path: degradation >prep_of [lemma='survivin'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj Complext?e1: trigger-arg-path: Positive_regulation nsubj Complext$e1: ents2Label-mention-ngram: ( E3 )t'interceding-token ngrams: to reduce thetZe1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj [lemma='ubiquitination'] controlledt9e1: args2Role-mention-ngram: ubiquitin protein isopeptidet)interceding-token ngrams: complex , whicht?e1: trigger-arg-path: catalyze nsubj controller:Complexte1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj [lemma='xaf1'] controllertqe2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='survivin'] controlled:Gene_or_gene_productt+e1: ents2Label-mention-ngram: ) activity totre1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt.interceding-token ngrams: reduce the formationthe1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj [lemma='xaf1'] Complext!e1: args2Role-mention-ngram: E3 )t0e1: args2Role-mention-ngram: catalyze CONTROLLEDt8e1: ents2Label-mention-ngram: and subsequently activatestGe1: trigger-arg-path: catalyze:Positive_regulation >dobj Ubiquitinationt(e1: ents2Label-mention-ngram: isopeptidetee2: trigger-arg-path: Negative_activation >prep_of [lemma='survivin'] controlled:Gene_or_gene_productt"interceding-token ngrams: HER2 andt/e1: trigger-arg-path: catalyze >dobj controlledte1: trigger: catalyzet/e1: ents2Label-mention-ngram: activates XIAP 'st'interceding-token ngrams: ERK was shownt%e1: ents2Label-mention-ngram: XIAP 'st|e1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj [lemma='xaf1'] Complext)e1: args2Role-mention-ngram: subsequentlyt$e1: args2Role-mention-ngram: XIAP 'stue1: trigger-arg-path: catalyze:Positive_regulation nsubj [lemma='xaf1'] controller:Complext\e2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='survivin'] controlledt0e1: args2Role-mention-ngram: isopeptide ligase (t.e1: args2Role-mention-ngram: isopeptide ligaset?e1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj [lemma='xaf1'] controller:Complext^e1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj [lemma='ubiquitination'] Ubiquitinationt'e1: args2Role-mention-ngram: isopeptidet'interceding-token ngrams: XIAP and XAF1t7e1: trigger-arg-path: catalyze nsubj controllert2e1: ents2Label-mention-ngram: activity to catalyzetCe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and subsequentlyt!interceding-token ngrams: ERK wast8e1: args2Role-mention-ngram: CONTROLLER and subsequentlyt&interceding-token ngrams: . Activationt+e1: args2Role-mention-ngram: activates XIAPt7e1: ents2Label-mention-ngram: protein isopeptide ligaset#e1: args2Role-mention-ngram: ( E3 )tae1: trigger-arg-path: catalyze nsubj [lemma='xaf1'] controller:Complext}e1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt.e1: args2Role-mention-ngram: XIAP 's ubiquitintVe1: trigger-arg-path: catalyze nsubj [lemma='xaf1'] ComplextEe1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj Ubiquitinationt e1: ents2Label-mention-ngram: 'st$interceding-token ngrams: reduce thetoe2: trigger-arg-path: lemmatizedTrigger=degradation >prep_of [lemma='survivin'] controlled:Gene_or_gene_productt(interceding-token ngrams: XAF1 complex ,t&interceding-token ngrams: the XIAP andt?e2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='survivin'] controlled:Gene_or_gene_productt/e1: ents2Label-mention-ngram: ubiquitin proteint$interceding-token ngrams: ActivationtYe1: trigger-arg-path: catalyze nsubj [lemma='xaf1'] controllertPe1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj controlled:UbiquitinationtQe1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj controller:Complext!e1: args2Role-mention-ngram: ( E3t9e1: ents2Label-mention-ngram: to GENE_OR_GENE_PRODUCT andt#interceding-token ngrams: catalysestne2: trigger-arg-path: lemmatizedTrigger=degradation:Negative_activation >prep_of [lemma='survivin'] controlledt%interceding-token ngrams: of HER2 andtIe1: trigger-arg-path: lemmatizedTrigger=catalyze nsubj controllert:e1: ents2Label-mention-ngram: ubiquitin protein isopeptidet+e1: ents2Label-mention-ngram: E3 ) activityt/e1: args2Role-mention-ngram: protein isopeptidet1e1: args2Role-mention-ngram: activity to catalyzet+interceding-token ngrams: , which catalysest]e1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj controllertne1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj [lemma='ubiquitination'] controlledt*e1: ents2Label-mention-ngram: subsequentlyt2e1: ents2Label-mention-ngram: 's ubiquitin proteint*e1: ents2Label-mention-ngram: 's ubiquitinte1: args2Role-mention-ngram: 'st&interceding-token ngrams: was shown tot/e1: ents2Label-mention-ngram: isopeptide ligaset]e2: trigger-arg-path: degradation >prep_of [lemma='survivin'] controlled:Gene_or_gene_productt#interceding-token ngrams: was shownt)e1: ents2Label-mention-ngram: ligase ( E3tPe2: trigger-arg-path: Negative_activation >prep_of [lemma='survivin'] controlledt*e1: args2Role-mention-ngram: ) activity totee1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation nsubj controller:Complext&interceding-token ngrams: HER2 and ERKtYe1: trigger-arg-path: lemmatizedTrigger=catalyze:Positive_regulation >dobj Ubiquitinationt3e1: args2Role-mention-ngram: subsequently activatestae1: trigger-arg-path: Positive_regulation nsubj [lemma='xaf1'] Complext4e1: trigger-arg-path: catalyze nsubj Complextie1: trigger-arg-path: lemmatizedTrigger=catalyze >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt'e1: args2Role-mention-ngram: ) activityt%interceding-token ngrams: and ERK wastfe2: trigger-arg-path: degradation:Negative_activation >prep_of [lemma='survivin'] Gene_or_gene_productt6e1: args2Role-mention-ngram: protein isopeptide ligaset4e1: ents2Label-mention-ngram: subsequently activatest(e1: ents2Label-mention-ngram: ) activityt.e1: ents2Label-mention-ngram: and subsequentlytme1: trigger-arg-path: catalyze:Positive_regulation nsubj [lemma='xaf1'] controllert"interceding-token ngrams: and XAF1t9e1: ents2Label-mention-ngram: subsequently activates XIAPt0e1: ents2Label-mention-ngram: to catalyze SHAREDt|e2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: reversed the SHAREDtge2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controllert_e2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: reversed:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: drastically reversed thet*e2: args2Role-mention-ngram: CONTROLLER byt*e2: ents2Label-mention-ngram: reversed thetWe2: trigger-arg-path: reversed:Negative_regulation >nsubj >prep_of Gene_or_gene_producttbe2: trigger-arg-path: reversed:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttCe2: trigger-arg-path: reversed >nsubj >prep_of Gene_or_gene_productt1e2: args2Role-mention-ngram: by siRNA drasticallyt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj >prep_of controllert2e2: ents2Label-mention-ngram: by siRNA drasticallyt.e2: args2Role-mention-ngram: siRNA drasticallytMe2: trigger-arg-path: reversed:Negative_regulation >nsubj >prep_of controllertqe2: trigger-arg-path: reversed >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controller:Gene_or_gene_productt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT by siRNAtTe2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj >prep_of Gene_or_gene_productt9e2: trigger-arg-path: reversed >nsubj >prep_of controllertme2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controllertqe2: trigger-arg-path: Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: siRNA drastically reversedt/e2: ents2Label-mention-ngram: siRNA drasticallytfe2: trigger-arg-path: reversed >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] Gene_or_gene_productt1e2: args2Role-mention-ngram: drastically reversedt\e2: trigger-arg-path: reversed >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj >prep_of controllert2e2: ents2Label-mention-ngram: drastically reversedt)e2: args2Role-mention-ngram: reversed thet[interceding-tokens-full-span: in a Pin1 dependent manner . Indeed , depletion of endogenoust1e2: ents2Label-mention-ngram: the SHARED promotedt7e2: args2Role-mention-ngram: siRNA drastically reversedtze2: trigger-arg-path: reversed:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] Gene_or_gene_producttNe2: trigger-arg-path: reversed >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: reversed the CONTROLLEDtwe2: trigger-arg-path: lemmatizedTrigger=reverse >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] Gene_or_gene_producttpe2: trigger-arg-path: reversed:Negative_regulation >nsubj [lemma='depletion'] >prep_of [lemma='pin1'] controllert6e2: ents2Label-mention-ngram: drastically reversed thetse2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=reverse:Negative_regulation >nsubj >prep_of Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER by siRNAt3e1: ents2Label-mention-ngram: monoubiquitination oft%e1: ents2Label-mention-ngram: core E3tae2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancus'] Gene_or_gene_productt1interceding-tokens-full-span: . Monoubiquitinatedt,e1: ents2Label-mention-ngram: FAMILY core E3tZe1: trigger-arg-path: Positive_regulation nn [lemma='FA'] Familyt$e1: args2Role-mention-ngram: core E3t)e1: args2Role-mention-ngram: E3 ubiquitintUe2: trigger-arg-path: complex:Binding >nn [lemma='fancus'] theme:Gene_or_gene_producttOe2: trigger-arg-path: complex:Binding >nn [lemma='fancus'] Gene_or_gene_producttke1: trigger-arg-path: leads:Positive_regulation nn [lemma='FA'] controller:Familyt9e1: ents2Label-mention-ngram: leads to monoubiquitinationtMe2: trigger-arg-path: complex >nn [lemma='fancd2'] theme:Gene_or_gene_productt-e1: trigger-arg-path: leads nn FamilytFe1: trigger-arg-path: Positive_regulation nn controller:FamilytLe1: trigger-arg-path: leads nn [lemma='FA'] Familyt;e1: trigger-arg-path: Positive_regulation nn Familyt1e1: trigger-arg-path: leads nn controllertYe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancd2'] Gene_or_gene_productt,e1: args2Role-mention-ngram: complex , whichtae1: trigger-arg-path: lemmatizedTrigger=lead nn [lemma='FA'] controllertMe2: trigger-arg-path: Binding >nn [lemma='fancd2'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: in turn leadstRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancd2'] themetge2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancd2'] theme:Gene_or_gene_producttde1: trigger-arg-path: leads:Positive_regulation nn [lemma='FA'] controllertRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancus'] themetGe2: trigger-arg-path: complex >nn [lemma='fancus'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: core E3 ubiquitint-interceding-token ngrams: . MonoubiquitinatedtMe2: trigger-arg-path: Binding >nn [lemma='fancus'] theme:Gene_or_gene_producttPe1: trigger-arg-path: leads nn [lemma='FA'] controllert9e1: ents2Label-mention-ngram: monoubiquitination of FANCIt&e1: ents2Label-mention-ngram: of FANCIt]e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn controller:Familyt+e1: ents2Label-mention-ngram: turn leads tot*e1: ents2Label-mention-ngram: E3 ubiquitintVe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn controllert,e1: args2Role-mention-ngram: CONTROLLER coret"e1: ents2Label-mention-ngram: coret.e1: ents2Label-mention-ngram: FANCI and SHAREDtue1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn [lemma='FA'] controllertge2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancus'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn [lemma='FA'] Familyt`e1: trigger-arg-path: leads:Positive_regulation nn [lemma='FA'] FamilytMe2: trigger-arg-path: complex >nn [lemma='fancus'] theme:Gene_or_gene_productt/CSSPATH: ROOT >dobj >rcmod ++ ROOT >csubj >dobjt^e1: trigger-arg-path: Positive_regulation nn [lemma='FA'] controllert'e1: ents2Label-mention-ngram: FANCI andt1e1: ents2Label-mention-ngram: E3 ubiquitin ligaset_e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancd2'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: complex ,tee1: trigger-arg-path: Positive_regulation nn [lemma='FA'] controller:Familyt/e1: args2Role-mention-ngram: CONTROLLER core E3tJe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancus'] themet8e1: trigger-arg-path: leads nn controller:FamilytGe2: trigger-arg-path: Binding >nn [lemma='fancd2'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: complex , whicht@e2: trigger-arg-path: complex:Binding >nn [lemma='fancus'] themet+interceding-token ngrams: Monoubiquitinatedt3e1: ents2Label-mention-ngram: to monoubiquitinationtOe2: trigger-arg-path: complex:Binding >nn [lemma='fancd2'] Gene_or_gene_producttAe1: trigger-arg-path: leads:Positive_regulation nn Familytae2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='fancd2'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=lead nn controller:Familyt]e1: trigger-arg-path: lemmatizedTrigger=lead nn [lemma='FA'] FamilytYe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancus'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=lead nn [lemma='FA'] controller:Familyt@e2: trigger-arg-path: complex:Binding >nn [lemma='fancd2'] themetJe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancd2'] themet|e1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn [lemma='FA'] controller:Familyt6e1: ents2Label-mention-ngram: to monoubiquitination oft.e1: ents2Label-mention-ngram: ligase complex ,t8e2: trigger-arg-path: complex >nn [lemma='fancus'] themetRe1: trigger-arg-path: lemmatizedTrigger=lead:Positive_regulation nn Familyt0e1: args2Role-mention-ngram: E3 ubiquitin ligaset#e1: ents2Label-mention-ngram: FANCItEe1: trigger-arg-path: leads:Positive_regulation nn controllertBe1: trigger-arg-path: lemmatizedTrigger=lead nn controllert0e1: args2Role-mention-ngram: leads to CONTROLLEDt>e1: trigger-arg-path: lemmatizedTrigger=lead nn Familyt_e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='fancus'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: FAMILY coret*e1: args2Role-mention-ngram: turn leads tot8e2: trigger-arg-path: complex >nn [lemma='fancd2'] themetUe2: trigger-arg-path: complex:Binding >nn [lemma='fancd2'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: monoubiquitinationt+e1: ents2Label-mention-ngram: in turn leadst(e1: ents2Label-mention-ngram: turn leadstGe2: trigger-arg-path: complex >nn [lemma='fancd2'] Gene_or_gene_productt.e1: args2Role-mention-ngram: core E3 ubiquitint!e1: args2Role-mention-ngram: coretLe1: trigger-arg-path: leads:Positive_regulation nn controller:Familyt8e2: trigger-arg-path: Binding >nn [lemma='fancd2'] themet*e1: ents2Label-mention-ngram: of FANCI andt'e1: args2Role-mention-ngram: turn leadstWe1: trigger-arg-path: leads nn [lemma='FA'] controller:Familyt-e1: args2Role-mention-ngram: ligase complex ,t8e2: trigger-arg-path: Binding >nn [lemma='fancus'] themetGe2: trigger-arg-path: Binding >nn [lemma='fancus'] Gene_or_gene_productt(e2: args2Role-mention-ngram: potentiatest.e1: args2Role-mention-ngram: ASPP2 bind activetUe2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='aspp2'] controllert^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp1'] theme:Gene_or_gene_productt#interceding-token ngrams: via theirtAe2: trigger-arg-path: activates >nsubj [lemma='aspp2'] controllertXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp1'] Gene_or_gene_producttKe2: trigger-arg-path: activates >nsubj [lemma='aspp2'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp1'] theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: signalling and activatest`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: RAS signallingt-e2: ents2Label-mention-ngram: potentiates RASt+e2: args2Role-mention-ngram: RAS signallingt:e1: trigger-arg-path: bind >dobj [lemma='ra'] theme:Familyt/e2: args2Role-mention-ngram: RAS signalling andt\e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='aspp2'] Gene_or_gene_productt+e1: args2Role-mention-ngram: and ASPP2 bindt2e2: ents2Label-mention-ngram: and activates SHAREDt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT potentiatest:e1: trigger-arg-path: Binding >nsubj [lemma='aspp1'] themet8e2: ents2Label-mention-ngram: potentiates RAS signallingt0e2: ents2Label-mention-ngram: RAS signalling andt,e2: args2Role-mention-ngram: potentiates RAStUe2: trigger-arg-path: Positive_activation >nsubj [lemma='aspp2'] Gene_or_gene_producttje2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='aspp2'] controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: signalling and activatest7e2: args2Role-mention-ngram: potentiates RAS signallingt!e2: ents2Label-mention-ngram: RASt?e1: trigger-arg-path: bind:Binding >nsubj [lemma='aspp1'] themetge2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='aspp2'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: bind active THEMEt/e1: ents2Label-mention-ngram: ASPP2 bind activet-e1: trigger-arg-path: bind >dobj theme:FamilytIe1: trigger-arg-path: Binding >nsubj [lemma='aspp1'] Gene_or_gene_producttdobj [lemma='ra'] Familyt'e1: args2Role-mention-ngram: ASPP2 bindt0e1: ents2Label-mention-ngram: bind active SHAREDt(e1: ents2Label-mention-ngram: ASPP2 bindtOe1: trigger-arg-path: Binding >nsubj [lemma='aspp1'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: bind activetTe1: trigger-arg-path: bind:Binding >nsubj [lemma='aspp1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='aspp2'] controllert7e1: trigger-arg-path: bind >nsubj [lemma='aspp1'] themet#interceding-token ngrams: N-terminit,e1: ents2Label-mention-ngram: and ASPP2 bindtBe1: trigger-arg-path: bind:Binding >dobj [lemma='ra'] theme:FamilytNe1: trigger-arg-path: bind:Binding >nsubj [lemma='aspp1'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='aspp2'] Gene_or_gene_productt-interceding-token ngrams: via their N-terminit{e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='aspp2'] controller:Gene_or_gene_producttBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT potentiates RASt7e2: args2Role-mention-ngram: CONTROLLER potentiates RASt;e1: trigger-arg-path: bind:Binding >dobj [lemma='ra'] themet e2: args2Role-mention-ngram: RAStQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='aspp1'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='aspp1'] themetfe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='aspp2'] controllert)interceding-token ngrams: their N-terminit,e2: ents2Label-mention-ngram: signalling andt+e2: args2Role-mention-ngram: signalling andtVe2: trigger-arg-path: activates >nsubj [lemma='aspp2'] controller:Gene_or_gene_productt/e1: trigger-arg-path: bind:Binding >dobj FamilytKe2: trigger-arg-path: Positive_activation >nsubj [lemma='aspp2'] controllert`e2: trigger-arg-path: Positive_activation >nsubj [lemma='aspp2'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: bind activet,e1: args2Role-mention-ngram: THEME and ASPP2t'e1: trigger-arg-path: bind >dobj FamilytLe1: trigger-arg-path: bind >nsubj [lemma='aspp1'] theme:Gene_or_gene_productt4e1: trigger-arg-path: bind >dobj [lemma='ra'] Familyt3e1: trigger-arg-path: bind >dobj [lemma='ra'] themet3interceding-tokens-full-span: via their N-termini .t5e2: args2Role-mention-ngram: and activates CONTROLLEDtdobj theme:FamilytFe1: trigger-arg-path: bind >nsubj [lemma='aspp1'] Gene_or_gene_productt_e2: trigger-arg-path: activates:Positive_activation >nsubj [lemma='aspp2'] Gene_or_gene_productt+interceding-token ngrams: their N-termini .t%interceding-token ngrams: N-termini .t)e2: ents2Label-mention-ngram: potentiatest3e2: args2Role-mention-ngram: CONTROLLER potentiatest,e1: ents2Label-mention-ngram: Akt and SHAREDtNe1: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] Phosphorylationt?interceding-tokens-full-span: ( data not shown ) . In contrast , inhibition of PI3K with the specific inhibitor LY 294002 preventedt9CSSPATH: ROOT >ccomp >dobj >prep_on >rcmod ++ ROOT >ccompt-interceding-token ngrams: LY 294002 preventedt4e1: args2Role-mention-ngram: CONTROLLER mediated Aktt)e1: args2Role-mention-ngram: mediated Aktt#interceding-token ngrams: PI3K witht_e1: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] Phosphorylationt0interceding-token ngrams: the specific inhibitortinterceding-token ngrams: LYt*interceding-token ngrams: 294002 preventedt interceding-token ngrams: 294002t,e2: ents2Label-mention-ngram: Akt and SHAREDtYe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj Phosphorylationtbe1: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt*e1: ents2Label-mention-ngram: mediated AkttEe1: trigger-arg-path: lemmatizedTrigger=mediate >dobj Phosphorylationt/e1: args2Role-mention-ngram: Akt and CONTROLLEDtse1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt8e1: ents2Label-mention-ngram: and SHARED phosphorylationt-interceding-token ngrams: inhibitor LY 294002t,interceding-token ngrams: specific inhibitort.e1: ents2Label-mention-ngram: mediated Akt andtne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] controlledtme1: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt'interceding-token ngrams: PI3K with thet]e1: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='phosphorylation'] controlledt/interceding-token ngrams: specific inhibitor LYtPe1: trigger-arg-path: lemmatizedTrigger=mediate >dobj controlled:Phosphorylationt+interceding-token ngrams: with the specifictZe1: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] controlledtSe1: trigger-arg-path: mediated:Positive_regulation >dobj controlled:Phosphorylationt?e1: trigger-arg-path: mediated >dobj controlled:Phosphorylationt&interceding-token ngrams: inhibitor LYt/e2: args2Role-mention-ngram: Akt and CONTROLLEDt&interceding-token ngrams: of PI3K witht,e2: args2Role-mention-ngram: induced Akt andt-e1: args2Role-mention-ngram: mediated Akt andt4e1: trigger-arg-path: mediated >dobj Phosphorylationt3e2: args2Role-mention-ngram: CONTROLLER induced Aktt$e2: args2Role-mention-ngram: Akt andtde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj controlled:Phosphorylationt#interceding-token ngrams: LY 294002t8e2: ents2Label-mention-ngram: and SHARED phosphorylationt(e2: args2Role-mention-ngram: induced Aktt&interceding-token ngrams: the specifict~e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtje1: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='phosphorylation'] controlled:Phosphorylationt#interceding-token ngrams: preventedt,interceding-token ngrams: inhibition of PI3Kt1e1: ents2Label-mention-ngram: SHARED mediated AkttIe1: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] controlledtHe1: trigger-arg-path: mediated:Positive_regulation >dobj PhosphorylationtYe1: trigger-arg-path: mediated >dobj [lemma='phosphorylation'] controlled:PhosphorylationtKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] Familyt'interceding-token ngrams: assay , whilet$interceding-token ngrams: effects oft7e2: args2Role-mention-ngram: cells increased CONTROLLEDt)interceding-token ngrams: Gal-3 in Panc-1tye2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt.interceding-token ngrams: affects Ras activitytle2: trigger-arg-path: increased >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] Gene_or_gene_productt(interceding-token ngrams: A3 ) decreasedt>e1: trigger-arg-path: interaction:Binding >prep_between Familyt%interceding-token ngrams: of Gal-3 intIe1: trigger-arg-path: interaction >prep_between [lemma='ra'] theme:FamilytQe1: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] theme:Familytinterceding-token ngrams: A3 )t.interceding-token ngrams: while overexpressiont[e2: trigger-arg-path: increased >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt'interceding-token ngrams: activity , wetle2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt)e2: args2Role-mention-ngram: BXPC-3 cellst$e2: ents2Label-mention-ngram: BXPC-3tTe1: trigger-arg-path: interaction >prep_between [lemma='gal-3'] Gene_or_gene_productt#interceding-token ngrams: in Panc-1tVe1: trigger-arg-path: Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt'interceding-token ngrams: activity . Ast)interceding-token ngrams: on Ras activityt?e2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of Gene_or_gene_productt interceding-token ngrams: Panc-1tWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] themetCe1: trigger-arg-path: interaction >prep_between [lemma='ra'] FamilytOe2: trigger-arg-path: increased:Positive_activation >dobj >nn controlled:Familyt,interceding-token ngrams: activity using thet interceding-token ngrams: ( A3 )t,interceding-token ngrams: manipulating Gal-3t&interceding-token ngrams: MPan96 cellstPe1: trigger-arg-path: Binding >prep_between [lemma='gal-3'] Gene_or_gene_producttJe1: trigger-arg-path: interaction:Binding >prep_between [lemma='ra'] themet(interceding-token ngrams: Ras activity ,t.e2: ents2Label-mention-ngram: SHARED in BXPC-3t.interceding-token ngrams: examined the effectst*interceding-token ngrams: Gal-3 expressiont%interceding-token ngrams: ) decreasedtne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] Gene_or_gene_productt+interceding-token ngrams: using the Ras-GTPtDe2: trigger-arg-path: increased:Positive_activation >dobj >nn Familytve2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controllertinterceding-tokens-full-span: affects Ras activity , we examined the effects of manipulating Gal-3 expression on Ras activity . As shown in , down regulation of Gal-3 in Panc-1 and MPan96 cells ( A3 ) decreased Ras activity using the Ras-GTP assay , while overexpression oftAe1: trigger-arg-path: Binding >prep_between [lemma='gal-3'] themet*e2: args2Role-mention-ngram: CONTROLLER int$interceding-token ngrams: Panc-1 andtprep_between theme:Familyt1interceding-token ngrams: effects of manipulatingt6e1: trigger-arg-path: interaction >prep_between Familyt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] Gene_or_gene_productt1CSSPATH: ROOT >advcl >advcl >nsubj ++ ROOT >advcltde2: trigger-arg-path: increased:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt(interceding-token ngrams: the effects oft&e2: args2Role-mention-ngram: in BXPC-3t#e2: args2Role-mention-ngram: BXPC-3t!interceding-token ngrams: Ras-GTPt'e2: ents2Label-mention-ngram: in BXPC-3t4e2: ents2Label-mention-ngram: cells increased SHAREDt;e2: trigger-arg-path: increased >dobj >nn controlled:Familytce2: trigger-arg-path: increased:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt(interceding-token ngrams: activity usingt4e2: ents2Label-mention-ngram: BXPC-3 cells increasedt1interceding-token ngrams: while overexpression oft-interceding-token ngrams: Gal-3 expression ont%interceding-token ngrams: affects Rastoe2: trigger-arg-path: increased:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familytse2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controllert(interceding-token ngrams: Ras activity .t'interceding-token ngrams: expression ont%interceding-token ngrams: we examinedtae2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gal-3'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt-e2: ents2Label-mention-ngram: cells increasedt\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] Gene_or_gene_productt+interceding-token ngrams: , down regulationt interceding-token ngrams: on RastDe2: trigger-arg-path: increased >nsubj >prep_of Gene_or_gene_productt)interceding-token ngrams: of manipulatingtZe1: trigger-arg-path: interaction >prep_between [lemma='gal-3'] theme:Gene_or_gene_producttDe1: trigger-arg-path: interaction:Binding >prep_between theme:Familythe2: trigger-arg-path: increased:Positive_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt%interceding-token ngrams: the Ras-GTPtle2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt!interceding-token ngrams: cells (t?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controllertte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_producttNe2: trigger-arg-path: increased:Positive_activation >nsubj >prep_of controllert"interceding-token ngrams: examinedt+interceding-token ngrams: Panc-1 and MPan96t-e2: ents2Label-mention-ngram: in BXPC-3 cellstve2: trigger-arg-path: Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] Gene_or_gene_producttOe2: trigger-arg-path: increased >nsubj >prep_of controller:Gene_or_gene_productt+interceding-token ngrams: expression on Rast,e2: args2Role-mention-ngram: cells increasedtXe2: trigger-arg-path: increased:Positive_activation >nsubj >prep_of Gene_or_gene_productt,interceding-token ngrams: Ras activity usingt+interceding-token ngrams: the Ras-GTP assayt:e2: trigger-arg-path: increased >nsubj >prep_of controllert_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gal-3'] themetBe1: trigger-arg-path: interaction >prep_between [lemma='ra'] themet'interceding-token ngrams: Ras-GTP assaytTe2: trigger-arg-path: increased >dobj [lemma='activity'] >nn [lemma='ra'] controlledt3e2: args2Role-mention-ngram: BXPC-3 cells increasedt"interceding-token ngrams: Gal-3 int$interceding-token ngrams: and MPan96t&interceding-token ngrams: examined thet,e2: args2Role-mention-ngram: in BXPC-3 cellst)interceding-token ngrams: Ras-GTP assay ,tinterceding-token ngrams: ( A3t/interceding-token ngrams: of manipulating Gal-3t7interceding-token ngrams: manipulating Gal-3 expressiontbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] theme:Gene_or_gene_productt interceding-token ngrams: MPan96t?e2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controller:Gene_or_gene_productt#interceding-token ngrams: in , downtMe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gal-3'] themetPe2: trigger-arg-path: increased >dobj [lemma='activity'] >nn [lemma='ra'] Familyt0e2: trigger-arg-path: increased >dobj >nn Familyt&interceding-token ngrams: manipulatingt*interceding-token ngrams: and MPan96 cellst)interceding-token ngrams: we examined thet!interceding-token ngrams: assay ,t?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controller:Gene_or_gene_productt'interceding-token ngrams: , we examinedt*e2: ents2Label-mention-ngram: BXPC-3 cellst}e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='ra'] controlledt interceding-token ngrams: , downt0interceding-token ngrams: , while overexpressiont)interceding-token ngrams: ) decreased Rastte2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER in BXPC-3t_e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >prep_of controllert$interceding-token ngrams: cells ( A3t?e2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] Gene_or_gene_productt%interceding-token ngrams: the effectstwe2: trigger-arg-path: increased >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controller:Gene_or_gene_productt(interceding-token ngrams: MPan96 cells (t#interceding-token ngrams: using thetinterceding-token ngrams: A3tbe2: trigger-arg-path: increased >nsubj [lemma='overexpression'] >prep_of [lemma='gal3'] controllert'interceding-token ngrams: in Panc-1 andtEe1: trigger-arg-path: interaction >prep_between [lemma='gal-3'] themet-interceding-token ngrams: from ubiquitinationt/e2: args2Role-mention-ngram: CONTROLLER inhibitt!interceding-token ngrams: it fromtne1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_productt/interceding-token ngrams: mouse double minute-2t0interceding-token ngrams: from ubiquitination bytAe2: trigger-arg-path: inhibit >nsubj [lemma='protein'] controllert?e1: trigger-arg-path: Acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p53'] controlledtze1: trigger-arg-path: Acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttFe2: trigger-arg-path: inhibit >dobj [lemma='p53'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: Acetylation of SHAREDtpe1: trigger-arg-path: Acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllertKe2: trigger-arg-path: inhibit >nsubj [lemma='protein'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='protein'] Gene_or_gene_productt+interceding-token ngrams: double minute-2 (twe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p53'] controlled:Gene_or_gene_producttVe2: trigger-arg-path: inhibit >nsubj [lemma='protein'] controller:Gene_or_gene_productt&interceding-token ngrams: its specifict&interceding-token ngrams: mouse doublet,interceding-token ngrams: Lysine120 residuest+interceding-token ngrams: ubiquitination byt0interceding-token ngrams: it from ubiquitinationtfe1: trigger-arg-path: Acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttZe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p53'] Gene_or_gene_producttge1: trigger-arg-path: Acetylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_productt_e2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='protein'] Gene_or_gene_producttRe2: trigger-arg-path: Negative_activation >dobj [lemma='p53'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p53'] controlledtSe1: trigger-arg-path: Acetylation >prep_of >prep_by controller:Gene_or_gene_producttDe2: trigger-arg-path: inhibit >nsubj controller:Gene_or_gene_producttMe2: trigger-arg-path: Negative_activation >nsubj [lemma='protein'] controllert)interceding-token ngrams: by its specifictZe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by Gene_or_gene_producttde1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllertge2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='protein'] controllert$interceding-token ngrams: minute-2 (t>e1: trigger-arg-path: Acetylation >prep_of >prep_by controllertye1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_productt]e2: trigger-arg-path: Negative_activation >dobj [lemma='p53'] controlled:Gene_or_gene_productt/interceding-token ngrams: at Lysine120 residuest2interceding-token ngrams: specific repressor mouset#interceding-token ngrams: Lysine120t?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt!interceding-token ngrams: ( Mdm-2t"interceding-token ngrams: minute-2tee2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p53'] controlled:Gene_or_gene_productte1: trigger: Acetylationt interceding-token ngrams: by itstCe2: trigger-arg-path: inhibit:Negative_activation >nsubj controllertne1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllertbe2: trigger-arg-path: Negative_activation >nsubj [lemma='protein'] controller:Gene_or_gene_productt?interceding-tokens-full-span: at Lysine120 residues protects it from ubiquitination by its specific repressor mouse double minute-2 ( Mdm-2 ) oncoprotein . Mdm-2t"interceding-token ngrams: protectstye1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt9e2: trigger-arg-path: inhibit >nsubj Gene_or_gene_productt!interceding-token ngrams: . Mdm-2t0interceding-token ngrams: its specific repressort#interceding-token ngrams: ( Mdm-2 )t?e1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttXe2: trigger-arg-path: inhibit:Negative_activation >nsubj controller:Gene_or_gene_producttqe1: trigger-arg-path: Acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: Acetylationt:e2: args2Role-mention-ngram: CONTROLLER inhibit CONTROLLEDt,e1: ents2Label-mention-ngram: Acetylation oft]e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='protein'] Gene_or_gene_productt'interceding-token ngrams: oncoprotein .t"interceding-token ngrams: residuest'interceding-token ngrams: ) oncoproteint%interceding-token ngrams: protects itt\e1: trigger-arg-path: Acetylation:Positive_regulation >prep_of >prep_by Gene_or_gene_productt0interceding-token ngrams: repressor mouse doublet|e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='protein'] controller:Gene_or_gene_producttdobj [lemma='p53'] controlledt+interceding-token ngrams: residues protectst)interceding-token ngrams: double minute-2t.interceding-token ngrams: residues protects itt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibitt?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllert/e2: trigger-arg-path: inhibit >nsubj controllertHe1: trigger-arg-path: Acetylation >prep_of >prep_by Gene_or_gene_producttWe2: trigger-arg-path: Negative_activation >nsubj [lemma='protein'] Gene_or_gene_productt\e1: trigger-arg-path: Acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllerthe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='protein'] controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by controllertee1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by controller:Gene_or_gene_producttPe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='p53'] controlledt*interceding-token ngrams: protects it fromtQe2: trigger-arg-path: inhibit >dobj [lemma='p53'] controlled:Gene_or_gene_productt/interceding-token ngrams: ubiquitination by itst,interceding-token ngrams: specific repressortPe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by controllert&interceding-token ngrams: at Lysine120t#interceding-token ngrams: repressortje2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='protein'] controller:Gene_or_gene_productt-interceding-token ngrams: oncoprotein . Mdm-2tSe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='protein'] controllert%interceding-token ngrams: oncoproteint-interceding-token ngrams: Mdm-2 ) oncoproteintUe2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='protein'] controllertinterceding-token ngrams: Mdm-2tAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibit SHAREDtce2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p53'] controlled:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='p53'] Gene_or_gene_productt!interceding-token ngrams: Mdm-2 )tRe1: trigger-arg-path: Acetylation:Positive_regulation >prep_of >prep_by controllertxe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_productt)interceding-token ngrams: ) oncoprotein .t)interceding-token ngrams: repressor mousetHe2: trigger-arg-path: Negative_activation >dobj [lemma='p53'] controlledt5interceding-token ngrams: Lysine120 residues protectstXe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='p53'] Gene_or_gene_producttMe2: trigger-arg-path: inhibit:Negative_activation >nsubj Gene_or_gene_productt*interceding-token ngrams: minute-2 ( Mdm-2t*interceding-token ngrams: show that duringt%interceding-token ngrams: of activityt+interceding-token ngrams: relevance remainst?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controller:Gene_or_gene_producttinterceding-token ngrams: ( SISt#interceding-token ngrams: of stresst interceding-token ngrams: Pak1 )tPe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] controllert&interceding-token ngrams: senescence (t+interceding-token ngrams: activated kinase1t+interceding-token ngrams: remains unknown .txe1: trigger-arg-path: Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controller:Gene_or_gene_productt'interceding-token ngrams: and relevancet%interceding-token ngrams: ( Cdc42 andt$interceding-token ngrams: senescencet*interceding-token ngrams: oncogene inducedtinterceding-tokens-full-span: ( Cdc42 and Rac1 ) - activated kinase1 ( Pak1 ) results in loss of activity , but the precise mechanism and relevance remains unknown . Here we show that during oncogene induced senescence or other forms of stress induced senescence ( SIS ) ,t)interceding-token ngrams: remains unknowntce1: trigger-arg-path: Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controllert!interceding-token ngrams: ( SIS )t#interceding-token ngrams: Cdc42 andt#interceding-token ngrams: . Here wet,interceding-token ngrams: induced senescencetKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated phosphorylationtee2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] controller:Gene_or_gene_productt#interceding-token ngrams: ) resultst)interceding-token ngrams: during oncogenet?e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] Gene_or_gene_productt(interceding-token ngrams: other forms oft_e1: trigger-arg-path: phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controllert-interceding-token ngrams: - activated kinase1t"interceding-token ngrams: forms oft'interceding-token ngrams: mechanism andt(interceding-token ngrams: or other formstte1: trigger-arg-path: phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controller:Gene_or_gene_productt$interceding-token ngrams: and Rac1 )t3interceding-token ngrams: stress induced senescencet*interceding-token ngrams: loss of activityt/interceding-token ngrams: and relevance remainst%interceding-token ngrams: that duringt!interceding-token ngrams: in losst?e2: trigger-arg-path: mediated >nsubj [lemma='pak1'] controllert interceding-token ngrams: Rac1 )t(interceding-token ngrams: stress inducedt}e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] Gene_or_gene_productt)interceding-token ngrams: forms of stresst"interceding-token ngrams: or othert1interceding-token ngrams: during oncogene inducedtse1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controllert&interceding-token ngrams: we show thatt3interceding-token ngrams: relevance remains unknownt)interceding-token ngrams: but the preciset!interceding-token ngrams: we showt!interceding-token ngrams: preciset-interceding-token ngrams: activated kinase1 (tZe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] Gene_or_gene_productt#interceding-token ngrams: kinase1 (tIe2: trigger-arg-path: mediated >nsubj [lemma='pak1'] Gene_or_gene_productt"interceding-token ngrams: oncogenet%interceding-token ngrams: other formstinterceding-token ngrams: Heret"interceding-token ngrams: Rac1 ) -t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controllert#interceding-token ngrams: relevancet'interceding-token ngrams: of activity ,t&interceding-token ngrams: ) results int!interceding-token ngrams: ( Cdc42t-interceding-token ngrams: senescence or othert(interceding-token ngrams: kinase1 ( Pak1t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_productt+interceding-token ngrams: precise mechanismt.interceding-token ngrams: induced senescence (t+interceding-token ngrams: of stress inducedt"interceding-token ngrams: ( Pak1 )tJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] controllert#CSSPATH: ROOT >nsubj ++ ROOT >ccompt'interceding-token ngrams: ) - activatedtinterceding-token ngrams: SIS )t%interceding-token ngrams: the preciset!interceding-token ngrams: Here wetSe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] controllertTe2: trigger-arg-path: mediated >nsubj [lemma='pak1'] controller:Gene_or_gene_productt]e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt5interceding-token ngrams: oncogene induced senescencetinterceding-token ngrams: Rac1t"interceding-token ngrams: and Rac1tye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controllert*interceding-token ngrams: senescence ( SISt'interceding-token ngrams: senescence ort interceding-token ngrams: . Heret interceding-token ngrams: ( Pak1t/interceding-token ngrams: induced senescence ortinterceding-token ngrams: SISt/interceding-token ngrams: precise mechanism andt(interceding-token ngrams: activity , butthe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_productt)interceding-token ngrams: results in losst(interceding-token ngrams: Cdc42 and Rac1t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] Gene_or_gene_productt!interceding-token ngrams: kinase1t%interceding-token ngrams: - activatedt/interceding-token ngrams: the precise mechanismtinterceding-token ngrams: Cdc42t1interceding-token ngrams: mechanism and relevancet(interceding-token ngrams: unknown . Heret!interceding-token ngrams: SIS ) ,t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] controller:Gene_or_gene_productt&interceding-token ngrams: Here we showtme1: trigger-arg-path: Positive_regulation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt(interceding-token ngrams: Pak1 ) resultstde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] controllert$interceding-token ngrams: in loss oftie1: trigger-arg-path: phosphorylation >prep_of [lemma='pgam'] >prep_by [lemma='p21'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt.interceding-token ngrams: that during oncogenet]e2: trigger-arg-path: Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_producttBe2: trigger-arg-path: Activated >nsubj [lemma='kinase'] controllertVe2: trigger-arg-path: Activated:Positive_activation >nsubj [lemma='kinase'] controllert9e1: trigger-arg-path: interacts >nsubj [lemma='ra'] themet\e2: trigger-arg-path: Activated:Positive_activation >dobj [lemma='raf'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: threonine protein kinaset-e1: args2Role-mention-ngram: and translocatestTinterceding-tokens-full-span: to the plasma membrane , where Raf becomes activated .t:e2: trigger-arg-path: Activated >dobj Gene_or_gene_productt0e2: ents2Label-mention-ngram: activates the dualthe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='kinase'] controller:Gene_or_gene_productt-e1: trigger-arg-path: interacts >nsubj Familyt+e1: ents2Label-mention-ngram: and threoninet'e1: args2Role-mention-ngram: the serinetJe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] themet3e1: trigger-arg-path: interacts >nsubj theme:Familyt;e2: trigger-arg-path: Activated >nsubj Gene_or_gene_productt0e2: trigger-arg-path: Activated >dobj controlledt(e1: ents2Label-mention-ngram: serine andtKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] FamilytYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] theme:Familyt:e1: trigger-arg-path: interacts >nsubj [lemma='ra'] Familyt2e1: args2Role-mention-ngram: with and translocatestre1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet-e1: args2Role-mention-ngram: translocates thet2e1: ents2Label-mention-ngram: serine and threoninetne1: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: translocatestge2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='kinase'] controllertve1: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt3e1: ents2Label-mention-ngram: with and translocatestYe1: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet.e1: args2Role-mention-ngram: threonine proteintxe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: Activatedt'e1: args2Role-mention-ngram: serine andt&e2: args2Role-mention-ngram: Activatedtce2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] controlledtEe2: trigger-arg-path: Activated:Positive_activation >nsubj controllert&e1: args2Role-mention-ngram: threoninet1e2: trigger-arg-path: Activated >nsubj controllert8e2: args2Role-mention-ngram: dual specificity CONTROLLERt)e2: ents2Label-mention-ngram: specificitytYe2: trigger-arg-path: Activated:Positive_activation >dobj controlled:Gene_or_gene_producttWe2: trigger-arg-path: Activated >nsubj [lemma='kinase'] controller:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='kinase'] Gene_or_gene_productt+interceding-token ngrams: where Raf becomestRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ra'] themet.e2: ents2Label-mention-ngram: dual specificitytye1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_productte2: trigger: Activatedt|e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_producttae1: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet2e1: ents2Label-mention-ngram: and translocates thet1e1: args2Role-mention-ngram: serine and threoninet%e2: args2Role-mention-ngram: the dualt'interceding-token ngrams: to the plasmatBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] Familytme2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='raf'] Gene_or_gene_producttpe1: trigger-arg-path: interacts:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_producttLe2: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] controllert+e1: args2Role-mention-ngram: the serine andtNe2: trigger-arg-path: Activated:Positive_activation >dobj Gene_or_gene_productt@e2: args2Role-mention-ngram: Activated CONTROLLED phosphorylatestWe1: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] themetAe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] themet1e2: args2Role-mention-ngram: Activated CONTROLLEDt!e2: args2Role-mention-ngram: dualtEe2: trigger-arg-path: Activated >dobj controlled:Gene_or_gene_productt;e1: trigger-arg-path: interacts:Binding >nsubj theme:Familyt3e1: ents2Label-mention-ngram: protein kinase SHAREDt5e1: ents2Label-mention-ngram: translocates the serinetRe2: trigger-arg-path: Positive_activation >dobj [lemma='raf'] Gene_or_gene_producttSe2: trigger-arg-path: Activated >dobj [lemma='raf'] controlled:Gene_or_gene_productt/interceding-token ngrams: Raf becomes activatedt*e1: args2Role-mention-ngram: and threoninetOe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] controlledt%interceding-token ngrams: Raf becomest(e2: args2Role-mention-ngram: specificityt2e1: args2Role-mention-ngram: and threonine proteint-e2: args2Role-mention-ngram: dual specificityt1e1: args2Role-mention-ngram: and translocates thet7e2: ents2Label-mention-ngram: SHARED phosphorylates andtle1: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: the dualtje1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] themet-interceding-token ngrams: becomes activated .t3e1: ents2Label-mention-ngram: and threonine proteint@e1: trigger-arg-path: interacts >nsubj [lemma='ra'] theme:Familyt%interceding-token ngrams: , where Raft*e1: ents2Label-mention-ngram: translocatestCe2: ents2Label-mention-ngram: dual specificity GENE_OR_GENE_PRODUCTt1e2: args2Role-mention-ngram: the dual specificityt=e2: ents2Label-mention-ngram: Activated SHARED phosphorylatest3e2: args2Role-mention-ngram: specificity CONTROLLERtHe2: trigger-arg-path: Positive_activation >dobj [lemma='raf'] controlledtZe2: trigger-arg-path: Activated:Positive_activation >nsubj controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ra'] theme:FamilytRe2: trigger-arg-path: Activated:Positive_activation >dobj [lemma='raf'] controlledt2e2: ents2Label-mention-ngram: the dual specificitythe1: trigger-arg-path: interacts >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_producttke2: trigger-arg-path: Activated:Positive_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_productt5e1: trigger-arg-path: interacts:Binding >nsubj FamilytYe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: Activated SHAREDt/e1: ents2Label-mention-ngram: threonine proteint%interceding-token ngrams: activated .tDe2: trigger-arg-path: Activated:Positive_activation >dobj controlledtFe2: trigger-arg-path: Activated >nsubj controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: translocates the serinetqe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='kinase'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: and translocatest`e2: trigger-arg-path: Activated:Positive_activation >nsubj [lemma='kinase'] Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='kinase'] controllertOe2: trigger-arg-path: Activated:Positive_activation >nsubj Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='raf'] controlled:Gene_or_gene_producttHe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ra'] theme:Familyt,e1: ents2Label-mention-ngram: the serine andt>e2: trigger-arg-path: Activated >dobj [lemma='raf'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='translocate'] >dobj [lemma='raf'] theme:Gene_or_gene_productt#interceding-token ngrams: where Raft+interceding-token ngrams: plasma membrane ,tLe2: trigger-arg-path: Activated >nsubj [lemma='kinase'] Gene_or_gene_producttfe1: trigger-arg-path: Binding >conj_and [lemma='translocate'] >dobj [lemma='raf'] Gene_or_gene_productt6e2: args2Role-mention-ngram: CONTROLLED phosphorylatest6e1: ents2Label-mention-ngram: threonine protein kinasetae2: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] controller:Gene_or_gene_productt"e2: ents2Label-mention-ngram: dualtHe2: trigger-arg-path: Activated >dobj [lemma='raf'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: translocates thet1e1: args2Role-mention-ngram: protein kinase THEMEt(e1: ents2Label-mention-ngram: the serinetVe2: trigger-arg-path: Positive_activation >nsubj [lemma='kinase'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: specificity GENE_OR_GENE_PRODUCTt3e1: ents2Label-mention-ngram: FAMILY interacts witht/e2: args2Role-mention-ngram: activates the dualt:e2: args2Role-mention-ngram: CONTROLLED phosphorylates andt.e1: ents2Label-mention-ngram: FAMILY interactstge2: trigger-arg-path: Activated:Positive_activation >dobj [lemma='raf'] controlled:Gene_or_gene_productt9e2: args2Role-mention-ngram: phosphorylates and activatestSe1: trigger-arg-path: bound:Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_producttge2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlledt"interceding-token ngrams: dependedt2e2: args2Role-mention-ngram: knockdown blocked thetge2: trigger-arg-path: blocked >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: siRNA knockdown blockedtue2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='k-ra'] Gene_or_gene_producttLe2: trigger-arg-path: blocked >dobj >prep_of controlled:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] Gene_or_gene_productt'interceding-token ngrams: Inhibition oftMe1: trigger-arg-path: Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj >prep_of controllert1e2: ents2Label-mention-ngram: blocked the hypoxictre2: trigger-arg-path: blocked >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controller:Gene_or_gene_productt(interceding-token ngrams: the activationtde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: treatment ort]e2: trigger-arg-path: blocked >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controllert-e2: ents2Label-mention-ngram: siRNA knockdownt?e2: trigger-arg-path: blocked:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlled:Gene_or_gene_productt+interceding-token ngrams: depended upon thetke2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlledt/e2: ents2Label-mention-ngram: knockdown blockedt!interceding-token ngrams: c-Src .t3e2: ents2Label-mention-ngram: hypoxic activation oft'interceding-token ngrams: depended upont|e2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: knockdownt?e2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: blocked:Positive_activation >dobj >prep_of Gene_or_gene_productt-e2: args2Role-mention-ngram: by PP2 treatmenttVe2: trigger-arg-path: blocked:Positive_activation >nsubj >prep_of Gene_or_gene_productt"interceding-token ngrams: of c-Srctme2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controllert$e2: ents2Label-mention-ngram: by PP2tinterceding-token ngrams: colontse2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] Gene_or_gene_productt-interceding-token ngrams: wild-type KRAS genet)interceding-token ngrams: in colon cancert[e2: trigger-arg-path: blocked >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlledt`e2: trigger-arg-path: blocked:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt0e2: ents2Label-mention-ngram: or siRNA knockdowntye2: trigger-arg-path: blocked:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT by PP2t,e2: args2Role-mention-ngram: siRNA knockdownt~e2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: hypoxic activationt&interceding-token ngrams: colon cancert/e2: args2Role-mention-ngram: or siRNA knockdowntLe2: trigger-arg-path: blocked:Positive_activation >nsubj >prep_of controllert,interceding-token ngrams: this depended upont%e2: args2Role-mention-ngram: or siRNAt3e2: ents2Label-mention-ngram: knockdown blocked thet0e2: args2Role-mention-ngram: blocked the hypoxict>e1: trigger-arg-path: bound:Binding >dobj [lemma='k-ra'] themet7e2: trigger-arg-path: blocked >dobj >prep_of controlledtee2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >prep_of Gene_or_gene_productt-interceding-token ngrams: upon the activationt0e2: ents2Label-mention-ngram: treatment or siRNAt$interceding-token ngrams: of c-Src .t4e2: ents2Label-mention-ngram: the hypoxic activationt&e2: args2Role-mention-ngram: knockdownt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controllertCSSPATH: ROOT >dep ++ ROOT t0e2: ents2Label-mention-ngram: hypoxic activationt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: the hypoxictKe2: trigger-arg-path: blocked:Positive_activation >dobj >prep_of controlledt/e2: args2Role-mention-ngram: treatment or siRNAt#e2: args2Role-mention-ngram: by PP2t interceding-token ngrams: with atRe2: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of Gene_or_gene_productt8e1: trigger-arg-path: Binding >dobj [lemma='k-ra'] themet8e2: trigger-arg-path: blocked >nsubj >prep_of controllert$interceding-token ngrams: , and thist$interceding-token ngrams: lines withtMe2: trigger-arg-path: blocked >nsubj >prep_of controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: blocked thet%interceding-token ngrams: KRAS gene ,t?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlled:Gene_or_gene_productt.e2: ents2Label-mention-ngram: PP2 treatment ort,interceding-token ngrams: c-Src . InhibitiontKe1: trigger-arg-path: bound >dobj [lemma='k-ra'] theme:Gene_or_gene_productt*interceding-token ngrams: a wild-type KRASt&e2: ents2Label-mention-ngram: or siRNAt"interceding-token ngrams: upon thet%e2: ents2Label-mention-ngram: hypoxictpe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >prep_of controlled:Gene_or_gene_productt*e2: args2Role-mention-ngram: PP2 treatmentt%interceding-token ngrams: a wild-typetGe2: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of controlledt4e2: args2Role-mention-ngram: siRNA knockdown blockedt!e2: ents2Label-mention-ngram: PP2t)interceding-token ngrams: cell lines witht.e2: args2Role-mention-ngram: CONTROLLER by PP2t+interceding-token ngrams: cancer cell linest'interceding-token ngrams: this dependedt"interceding-token ngrams: in colont?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] Gene_or_gene_productt6e1: trigger-arg-path: bound >dobj [lemma='k-ra'] themetinterceding-token ngrams: c-Srct\e2: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj >prep_of controlledt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controller:Gene_or_gene_productt?e2: trigger-arg-path: blocked:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controller:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] themet"interceding-token ngrams: and thist&interceding-token ngrams: . Inhibitiont(e2: args2Role-mention-ngram: the hypoxictGe1: trigger-arg-path: Binding >dobj [lemma='k-ra'] Gene_or_gene_producttoe2: trigger-arg-path: blocked:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlledtEe1: trigger-arg-path: bound >dobj [lemma='k-ra'] Gene_or_gene_producttee2: trigger-arg-path: blocked >dobj [lemma='activation'] >prep_of [lemma='k-ra'] Gene_or_gene_producttpe2: trigger-arg-path: blocked >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlled:Gene_or_gene_productt{e2: trigger-arg-path: blocked:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] Gene_or_gene_producttMe1: trigger-arg-path: bound:Binding >dobj [lemma='k-ra'] Gene_or_gene_productt&interceding-token ngrams: lines with at$interceding-token ngrams: cell linestfe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj >prep_of Gene_or_gene_productt(e2: args2Role-mention-ngram: blocked thet?interceding-tokens-full-span: in colon cancer cell lines with a wild-type KRAS gene , and this depended upon the activation of c-Src . Inhibition oft2e2: args2Role-mention-ngram: hypoxic activation oft+e2: ents2Label-mention-ngram: PP2 treatmenttOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='k-ra'] themetqe2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt*interceding-token ngrams: with a wild-typet.e2: ents2Label-mention-ngram: by PP2 treatmenttqe2: trigger-arg-path: blocked:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controllertQe2: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of Gene_or_gene_producttae2: trigger-arg-path: blocked:Positive_activation >nsubj >prep_of controller:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] Gene_or_gene_productt$interceding-token ngrams: Inhibitiont-interceding-token ngrams: activation of c-Srcte2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] controlledt]e2: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controller:Gene_or_gene_productt#interceding-token ngrams: KRAS genet)interceding-token ngrams: . Inhibition oft+interceding-token ngrams: the activation oft*e2: ents2Label-mention-ngram: treatment ort+interceding-token ngrams: and this dependedt3e2: args2Role-mention-ngram: the hypoxic activationtie2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='c-src'] controllert+interceding-token ngrams: colon cancer cellt-e2: args2Role-mention-ngram: PP2 treatment ortinterceding-token ngrams: linestqe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >prep_of [lemma='k-ra'] Gene_or_gene_productt(interceding-token ngrams: wild-type KRAStBe2: trigger-arg-path: blocked >nsubj >prep_of Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=block >nsubj >prep_of controllertAe2: trigger-arg-path: blocked >dobj >prep_of Gene_or_gene_productt.e2: args2Role-mention-ngram: knockdown blockedt e2: args2Role-mention-ngram: PP2t$e2: args2Role-mention-ngram: hypoxict\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='k-ra'] theme:Gene_or_gene_productt$interceding-token ngrams: gene , andtye2: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttRe1: trigger-arg-path: Positive_activation >prep_by controller:Gene_or_gene_producttGe1: trigger-arg-path: Positive_activation >prep_by Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by [lemma='tip60'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >prep_by [lemma='tip60'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn [lemma='p53'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: acetylation >prep_of >prep_by Gene_or_gene_producttCe1: trigger-arg-path: signaling >prep_by [lemma='tip60'] controllert\e1: trigger-arg-path: signaling:Positive_activation >prep_by controller:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn [lemma='p53'] controlledtXe1: trigger-arg-path: lemmatizedTrigger=signaling >nn [lemma='p53'] Gene_or_gene_producttPe1: trigger-arg-path: Positive_activation >nn [lemma='p53'] Gene_or_gene_producttde2: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllertse1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by [lemma='tip60'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: signaling byt8e1: trigger-arg-path: signaling >nn Gene_or_gene_productt4e1: args2Role-mention-ngram: signaling by CONTROLLERtZe2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by Gene_or_gene_producttCe1: trigger-arg-path: signaling >nn controlled:Gene_or_gene_producttointerceding-tokens-full-span: occurs through both K120 acetylation dependent and -independent mechanisms . K120tWe1: trigger-arg-path: signaling:Positive_activation >prep_by [lemma='tip60'] controllert3interceding-token ngrams: acetylation dependent andtMe1: trigger-arg-path: signaling >prep_by [lemma='tip60'] Gene_or_gene_producttnn [lemma='p53'] controlledtle1: trigger-arg-path: signaling:Positive_activation >prep_by [lemma='tip60'] controller:Gene_or_gene_productt=e1: trigger-arg-path: Positive_activation >prep_by controllert&interceding-token ngrams: through bothtfe2: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_productt&interceding-token ngrams: mechanisms .tGe1: trigger-arg-path: signaling:Positive_activation >prep_by controllertge2: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by [lemma='tip60'] controllertce1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by controller:Gene_or_gene_productt*interceding-token ngrams: and -independentt3e1: trigger-arg-path: signaling >prep_by controllertWe1: trigger-arg-path: signaling:Positive_activation >nn controlled:Gene_or_gene_producttLe1: trigger-arg-path: signaling:Positive_activation >nn Gene_or_gene_productt@e1: trigger-arg-path: lemmatizedTrigger=signaling >nn controlledtFe1: trigger-arg-path: Positive_activation >nn [lemma='p53'] controlledtce1: trigger-arg-path: lemmatizedTrigger=signaling >nn [lemma='p53'] controlled:Gene_or_gene_producttWe1: trigger-arg-path: Positive_activation >prep_by [lemma='tip60'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttSe2: trigger-arg-path: acetylation >prep_of >prep_by controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by [lemma='tip60'] controller:Gene_or_gene_productt&interceding-token ngrams: -independentt4e1: args2Role-mention-ngram: CONTROLLED signaling bytMe1: trigger-arg-path: Positive_activation >prep_by [lemma='tip60'] controllert+interceding-token ngrams: mechanisms . K120t>e2: trigger-arg-path: acetylation >prep_of >prep_by controllert.e1: trigger-arg-path: signaling >nn controlledtJe1: trigger-arg-path: lemmatizedTrigger=signaling >nn Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by controllertle1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn [lemma='p53'] Gene_or_gene_productt\e2: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=signaling >nn controlled:Gene_or_gene_productt1e1: ents2Label-mention-ngram: signaling by SHAREDt=e1: trigger-arg-path: signaling >prep_by Gene_or_gene_productt1interceding-token ngrams: -independent mechanismst?e2: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by controllert0CSSPATH: ROOT >nsubj >prep_of ++ ROOT >nsubjpasstQe1: trigger-arg-path: signaling:Positive_activation >prep_by Gene_or_gene_producttze2: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttPe1: trigger-arg-path: signaling:Positive_activation >nn [lemma='p53'] controlledt(interceding-token ngrams: occurs throught)e1: args2Role-mention-ngram: signaling bytne2: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttae1: trigger-arg-path: signaling:Positive_activation >prep_by [lemma='tip60'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: SHARED signaling byt^e1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn Gene_or_gene_productt\e2: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllertpe2: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllert3interceding-token ngrams: -independent mechanisms .t+interceding-token ngrams: through both K120tHe1: trigger-arg-path: signaling >prep_by controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by controller:Gene_or_gene_producttqe2: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn controlledtPe2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of >prep_by controllert/interceding-token ngrams: acetylation dependenttie1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by [lemma='tip60'] controllertRe2: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by controllertne2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by controller:Gene_or_gene_producttFe1: trigger-arg-path: signaling >nn [lemma='p53'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllert1e1: args2Role-mention-ngram: CONTROLLED signalingt-interceding-token ngrams: occurs through botht?e2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='tip60'] controllerte1: trigger: signalingt5interceding-token ngrams: and -independent mechanismstNe1: trigger-arg-path: lemmatizedTrigger=signaling >nn [lemma='p53'] controlledt interceding-token ngrams: . K120tXe1: trigger-arg-path: signaling >prep_by [lemma='tip60'] controller:Gene_or_gene_productt4interceding-token ngrams: dependent and -independentt4interceding-token ngrams: K120 acetylation dependentt/interceding-token ngrams: both K120 acetylationtie1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >nn controlled:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=signaling:Positive_activation >prep_by [lemma='tip60'] controller:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=signaling >prep_by controllertee1: trigger-arg-path: signaling:Positive_activation >nn [lemma='p53'] controlled:Gene_or_gene_producttZe1: trigger-arg-path: signaling:Positive_activation >nn [lemma='p53'] Gene_or_gene_productt#interceding-token ngrams: both K120tBe1: trigger-arg-path: signaling:Positive_activation >nn controlledtye2: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_producttQe1: trigger-arg-path: signaling >nn [lemma='p53'] controlled:Gene_or_gene_productt[e1: trigger-arg-path: Positive_activation >nn [lemma='p53'] controlled:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pkczetaius'] themetne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pvhl'] Gene_or_gene_productt.e1: args2Role-mention-ngram: also mediates thet$interceding-token ngrams: ; Iturriozt$interceding-token ngrams: and Parkert5e1: args2Role-mention-ngram: CONTROLLER also mediatest+e1: ents2Label-mention-ngram: atypical PKCstZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pvhl'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pvhl'] controllertLe2: trigger-arg-path: Binding >prep_with [lemma='par6'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='par6'] themet*e1: ents2Label-mention-ngram: , and SHAREDt"interceding-token ngrams: Okuda ett interceding-token ngrams: ParkertGe2: trigger-arg-path: interacts:Binding >prep_with [lemma='par6'] themetZe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pkczetaius'] themetinterceding-token ngrams: Okudatee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='par6'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pvhl'] controller:Gene_or_gene_producttSe1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pvhl'] controllert@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also mediatest-e1: ents2Label-mention-ngram: atypical PKCs ,t*e1: args2Role-mention-ngram: also mediatestNe2: trigger-arg-path: Binding >nsubj [lemma='pkczetaius'] Gene_or_gene_producttTe2: trigger-arg-path: Binding >nsubj [lemma='pkczetaius'] theme:Gene_or_gene_producttIe1: trigger-arg-path: mediates >nsubj [lemma='pvhl'] Gene_or_gene_productthe1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pvhl'] controller:Gene_or_gene_producttVe2: trigger-arg-path: interacts >nsubj [lemma='pkczetaius'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: also mediates thet^e2: trigger-arg-path: interacts:Binding >nsubj [lemma='pkczetaius'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: PKCs ,tXe2: trigger-arg-path: interacts:Binding >nsubj [lemma='pkczetaius'] Gene_or_gene_productt\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='par6'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interacts >prep_with [lemma='par6'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts:Binding >prep_with [lemma='par6'] Gene_or_gene_productt$interceding-token ngrams: ( Okuda ettoe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pkczetaius'] theme:Gene_or_gene_productt$interceding-token ngrams: Parker , )t?e2: trigger-arg-path: Binding >nsubj [lemma='pkczetaius'] themetae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pkczetaius'] Gene_or_gene_producttIe2: trigger-arg-path: interacts:Binding >nsubj [lemma='pkczetaius'] themetge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='par6'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: polyubiquitination of thetNe2: trigger-arg-path: interacts >prep_with [lemma='par6'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: , PKClambda ,t"interceding-token ngrams: IturrioztRe2: trigger-arg-path: Binding >prep_with [lemma='par6'] theme:Gene_or_gene_producttTe1: trigger-arg-path: mediates >nsubj [lemma='pvhl'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: PKClambda ,t&interceding-token ngrams: Iturrioz andt-e1: ents2Label-mention-ngram: of the atypicaltie2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pkczetaius'] Gene_or_gene_productt!interceding-token ngrams: ( Okudat/e1: ents2Label-mention-ngram: the atypical PKCstge2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pkczetaius'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: PKCstJinterceding-tokens-full-span: ( Okuda et al. , ; Iturrioz and Parker , ) .t&interceding-token ngrams: , ; Iturriozt"interceding-token ngrams: Parker ,t&interceding-token ngrams: Okuda et al.tye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pvhl'] controller:Gene_or_gene_productt?e2: trigger-arg-path: interacts >prep_with [lemma='par6'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='par6'] themet_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='par6'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: mediates the polyubiquitinationt&e1: ents2Label-mention-ngram: atypicalt&interceding-token ngrams: and Parker ,tPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pvhl'] controllertAe2: trigger-arg-path: interacts >nsubj [lemma='pkczetaius'] themet)e1: ents2Label-mention-ngram: , PKClambdat?e1: trigger-arg-path: mediates >nsubj [lemma='pvhl'] controllert.e1: ents2Label-mention-ngram: PKCs , PKClambdatPe2: trigger-arg-path: interacts >nsubj [lemma='pkczetaius'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: PKClambda , andtPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='par6'] themet*e1: ents2Label-mention-ngram: the atypicaltme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='par6'] theme:Gene_or_gene_productt(interceding-token ngrams: ; Iturrioz andt+e1: ents2Label-mention-ngram: also mediatest]e1: trigger-arg-path: mediates:Positive_regulation >nsubj [lemma='pvhl'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: PKClambdat-interceding-token ngrams: Iturrioz and Parkert$e2: args2Role-mention-ngram: mitogent*interceding-token ngrams: critical for TSAt,interceding-token ngrams: choriogonadotropintie2: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt"interceding-token ngrams: was alsot+interceding-token ngrams: gene expression .t+interceding-token ngrams: ) gene expressiont?e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='pkczeta'] controllert:interceding-token ngrams: by phosphatidylinositol 3-kinaset"interceding-token ngrams: lutropint.e2: ents2Label-mention-ngram: SHARED at Thr453t1interceding-token ngrams: by phosphatidylinositolte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert+interceding-token ngrams: for TSA activatedt"interceding-token ngrams: 3-kinaset9interceding-token ngrams: indicating that phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] controllert7e2: ents2Label-mention-ngram: ) directly phosphorylatestinterceding-token ngrams: ( LHRt-e2: ents2Label-mention-ngram: and p44 mitogent[e1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by Gene_or_gene_productt$interceding-token ngrams: 3-kinase (t9interceding-token ngrams: phosphatidylinositol 3-kinase (t'e2: ents2Label-mention-ngram: at Thr453tfe1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by controller:Gene_or_gene_producttSe1: trigger-arg-path: phosphorylation:Positive_regulation prep_by controllert+interceding-token ngrams: was also reportedtee1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by controllert)interceding-token ngrams: is critical fortZe2: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert*e2: args2Role-mention-ngram: kinase ( MAPKt&interceding-token ngrams: critical fort#e2: args2Role-mention-ngram: ( MAPKt!interceding-token ngrams: ( LHR )t0interceding-token ngrams: and choriogonadotropinthe1: trigger-arg-path: phosphorylation:Positive_regulation prep_by controller:Gene_or_gene_productt%interceding-token ngrams: It was alsot,e2: args2Role-mention-ngram: and p44 mitogent2e2: args2Role-mention-ngram: p44 mitogen activatedt)interceding-token ngrams: gene expressiont!interceding-token ngrams: for TSAt.interceding-token ngrams: phosphatidylinositoltxe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_producttue1: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] controllert}e1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='pkczeta'] Gene_or_gene_producttze1: trigger-arg-path: Positive_regulation prep_by [lemma='pkczeta'] controller:Gene_or_gene_producttve1: trigger-arg-path: phosphorylation prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt$interceding-token ngrams: PKCzeta ist,interceding-token ngrams: also reported thatt-interceding-token ngrams: PKCzeta is criticalt!e2: ents2Label-mention-ngram: p44t+e2: ents2Label-mention-ngram: kinase ( MAPKt.e2: args2Role-mention-ngram: mitogen activatedt%e2: ents2Label-mention-ngram: and p44t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt0interceding-token ngrams: TSA activated lutropint interceding-token ngrams: PI3K )t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] Gene_or_gene_productte1: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: MAPK ) directlytCe1: trigger-arg-path: Positive_regulation prep_by controllert2e2: args2Role-mention-ngram: ) directly CONTROLLEDt(interceding-token ngrams: receptor ( LHRtinterceding-tokens-full-span: in JAR and MCF-7 cells , indicating that phosphorylation of Sp1 by phosphatidylinositol 3-kinase ( PI3K ) / PKCzeta is critical for TSA activated lutropin and choriogonadotropin receptor ( LHR ) gene expression . It was also reported thattke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert(e2: ents2Label-mention-ngram: ) directlyt7interceding-token ngrams: phosphatidylinositol 3-kinaset7interceding-token ngrams: choriogonadotropin receptor (t.interceding-token ngrams: that phosphorylationt interceding-token ngrams: It wastoe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by Gene_or_gene_productt?e1: trigger-arg-path: phosphorylation prep_by controllert/e2: args2Role-mention-ngram: CONTROLLER and p44t'interceding-token ngrams: TSA activatedt,e2: args2Role-mention-ngram: MAPK ) directlyt$e2: ents2Label-mention-ngram: MAPK )t9interceding-token ngrams: lutropin and choriogonadotropint'e2: args2Role-mention-ngram: ) directlyt/e2: ents2Label-mention-ngram: mitogen activatedt]e1: trigger-arg-path: phosphorylation:Positive_regulation prep_by Gene_or_gene_productt$e2: ents2Label-mention-ngram: Thr453t5interceding-token ngrams: Sp1 by phosphatidylinositolt?e1: trigger-arg-path: phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt#e2: args2Role-mention-ngram: MAPK )t#interceding-token ngrams: / PKCzetat!interceding-token ngrams: PKCzetatoe1: trigger-arg-path: Positive_regulation prep_by [lemma='pkczeta'] Gene_or_gene_productt interceding-token ngrams: ) genetoe2: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_producttIe1: trigger-arg-path: phosphorylation prep_by Gene_or_gene_productt)interceding-token ngrams: 3-kinase ( PI3Kt$interceding-token ngrams: LHR ) genet)e2: ents2Label-mention-ngram: p44 mitogent0interceding-token ngrams: phosphorylation of Sp1t#interceding-token ngrams: of Sp1 byt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllert"interceding-token ngrams: PI3K ) /tae1: trigger-arg-path: phosphorylation prep_by [lemma='pkczeta'] controllert0interceding-token ngrams: activated lutropin andt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt6e2: args2Role-mention-ngram: mitogen activated proteint)CSSPATH: ROOT >ccomp >dobj ++ ROOT >ccompt interceding-token ngrams: ( PI3Kt,interceding-token ngrams: activated lutropint interceding-token ngrams: of Sp1t%e2: args2Role-mention-ngram: ( MAPK )tinterceding-token ngrams: LHR )tinterceding-token ngrams: LHRt&interceding-token ngrams: lutropin andtde2: trigger-arg-path: phosphorylates >nsubj [lemma='mitogen'] >nn [lemma='p42'] Gene_or_gene_productt"interceding-token ngrams: . It wast e2: args2Role-mention-ngram: p44t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: and p44t%interceding-token ngrams: ) / PKCzetatMe1: trigger-arg-path: Positive_regulation prep_by Gene_or_gene_productt%e2: ents2Label-mention-ngram: mitogentXe1: trigger-arg-path: Positive_regulation prep_by controller:Gene_or_gene_producttke1: trigger-arg-path: phosphorylation prep_by [lemma='pkczeta'] Gene_or_gene_producttTe1: trigger-arg-path: phosphorylation prep_by controller:Gene_or_gene_productt1interceding-token ngrams: that phosphorylation oftQe1: trigger-arg-path: lemmatizedTrigger=phosphorylation prep_by controllert3e2: ents2Label-mention-ngram: p44 mitogen activatedt'interceding-token ngrams: reported thattne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controllertinterceding-token ngrams: ) /t interceding-token ngrams: Sp1 byt(e2: args2Role-mention-ngram: p44 mitogentee1: trigger-arg-path: Positive_regulation prep_by [lemma='pkczeta'] controllert5interceding-token ngrams: choriogonadotropin receptort&e2: ents2Label-mention-ngram: ( MAPK )tze1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by controller:Gene_or_gene_productt'interceding-token ngrams: also reportedt%interceding-token ngrams: is criticaltte2: trigger-arg-path: Positive_regulation >nsubj [lemma='mitogen'] >nn [lemma='p42'] controller:Gene_or_gene_productt)interceding-token ngrams: expression . Itt9interceding-token ngrams: and choriogonadotropin receptort?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation prep_by [lemma='pkczeta'] controller:Gene_or_gene_productt&interceding-token ngrams: / PKCzeta ist7e2: ents2Label-mention-ngram: mitogen activated proteint:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and p44t"interceding-token ngrams: ( PI3K )t$e2: ents2Label-mention-ngram: ( MAPKt?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='pkcdelta'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='sfk'] controllert)interceding-token ngrams: and activated ,t-interceding-token ngrams: activated , leadingt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='cdcp1'] theme:Gene_or_gene_producttinterceding-token ngrams: SFKstqe1: trigger-arg-path: forms a complex nsubj [lemma='pkcdelta'] themet?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='cdcp1'] theme:Gene_or_gene_productt$interceding-token ngrams: and SFKs ,tre1: trigger-arg-path: forms a complex prep_with [lemma='cdcp1'] themet!interceding-token ngrams: anoikist\e2: trigger-arg-path: phosphorylation >prep_by [lemma='sfk'] controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='sfk'] controllert#interceding-token ngrams: SFKs , ist+interceding-token ngrams: phosphorylated byt?e1: trigger-arg-path: forms a complex nsubj [lemma='pkcdelta'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='pkcdelta'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='sfk'] Gene_or_gene_productt.interceding-token ngrams: is phosphorylated byt4interceding-token ngrams: resistance . Interestinglyt+interceding-token ngrams: is phosphorylatedtne2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='sfk'] controller:Gene_or_gene_producttie1: trigger-arg-path: Binding nsubj [lemma='pkcdelta'] themet~e1: trigger-arg-path: Binding nsubj [lemma='pkcdelta'] theme:Gene_or_gene_producttxe1: trigger-arg-path: Binding nsubj [lemma='pkcdelta'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='cdcp1'] Gene_or_gene_productt interceding-token ngrams: SFKs ,t,interceding-token ngrams: anoikis resistancetze1: trigger-arg-path: forms a complex:Binding prep_with [lemma='cdcp1'] themet0interceding-token ngrams: phosphorylated by SFKst?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='pkcdelta'] themet[e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='sfk'] controllertye1: trigger-arg-path: forms a complex:Binding nsubj [lemma='pkcdelta'] themet&interceding-token ngrams: resistance .t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='cdcp1'] themet%interceding-token ngrams: by SFKs andt/interceding-token ngrams: to anoikis resistancet.interceding-token ngrams: anoikis resistance .t"interceding-token ngrams: SFKs andt'interceding-token ngrams: and activatedtee2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='sfk'] Gene_or_gene_productt$interceding-token ngrams: to anoikist%interceding-token ngrams: activated ,t?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='pkcdelta'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Positive_regulation >prep_by [lemma='sfk'] Gene_or_gene_producttpe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_by [lemma='sfk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: forms a complex:Binding prep_with [lemma='cdcp1'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_regulation >prep_by [lemma='sfk'] controllertinterceding-token ngrams: , ist?e1: trigger-arg-path: forms a complex prep_with [lemma='cdcp1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: forms a complex prep_with [lemma='cdcp1'] Gene_or_gene_producttye1: trigger-arg-path: Binding prep_with [lemma='cdcp1'] Gene_or_gene_productt-interceding-token ngrams: , is phosphorylatedt?e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='pkcdelta'] theme:Gene_or_gene_producttGe2: trigger-arg-path: phosphorylation >prep_by [lemma='sfk'] controllert`e2: trigger-arg-path: Positive_regulation >prep_by [lemma='sfk'] controller:Gene_or_gene_productt!interceding-token ngrams: by SFKst?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='pkcdelta'] themet?interceding-tokens-full-span: and SFKs , is phosphorylated by SFKs and activated , leading to anoikis resistance . Interestingly ,t?e1: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='pkcdelta'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_by [lemma='sfk'] controller:Gene_or_gene_productt?e1: trigger-arg-path: forms a complex nsubj [lemma='pkcdelta'] Gene_or_gene_producttje1: trigger-arg-path: Binding prep_with [lemma='cdcp1'] themet?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='cdcp1'] theme:Gene_or_gene_productt(interceding-token ngrams: phosphorylatedt,interceding-token ngrams: SFKs and activatedtQe2: trigger-arg-path: phosphorylation >prep_by [lemma='sfk'] Gene_or_gene_productt"interceding-token ngrams: and SFKst?e1: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='cdcp1'] Gene_or_gene_productte1: trigger-arg-path: Binding prep_with [lemma='cdcp1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='cdcp1'] themet,interceding-token ngrams: leading to anoikist?e1: trigger-arg-path: forms a complex:Binding nsubj [lemma='pkcdelta'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_by [lemma='sfk'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: and Thr739t$e2: ents2Label-mention-ngram: Thr739t+e2: ents2Label-mention-ngram: at Thr453 andt(e2: ents2Label-mention-ngram: Thr453 andt/e2: ents2Label-mention-ngram: Thr453 and Thr739t'e1: ents2Label-mention-ngram: moleculestme2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] themet1e1: args2Role-mention-ngram: signalling moleculest)interceding-token ngrams: domain of SOCS1tinterceding-token ngrams: ITK ,tinterceding-token ngrams: GRB2t?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] theme:Gene_or_gene_producttGe1: ents2Label-mention-ngram: signalling molecules GENE_OR_GENE_PRODUCTt#interceding-token ngrams: P85 , NcKt/interceding-token ngrams: the N-terminal domaintSe2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] Gene_or_gene_productt?interceding-tokens-full-span: , GRB2 , P85 , NcK , ITK , and FGH through interaction of their SH3 domains with proline motifs in the N-terminal domain of SOCS1 . While thetinterceding-token ngrams: , ITKt!interceding-token ngrams: , NcK ,t&interceding-token ngrams: of their SH3tYe2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] theme:Gene_or_gene_producttprep_of [lemma='socs1'] themethe2: trigger-arg-path: binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] theme:Gene_or_gene_productt.interceding-token ngrams: interaction of theirtbe2: trigger-arg-path: Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] Gene_or_gene_productt)interceding-token ngrams: and FGH throught0interceding-token ngrams: through interaction oft1interceding-token ngrams: FGH through interactiontze2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: the signalling moleculest|e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vav'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] themet*interceding-token ngrams: SH3 domains witht#interceding-token ngrams: motifs int[e2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] themet:e1: trigger-arg-path: Binding >prep_to [lemma='vav'] themet(interceding-token ngrams: proline motifst-interceding-token ngrams: with proline motifstfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vav'] theme:Gene_or_gene_producttbe2: trigger-arg-path: binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs1'] Gene_or_gene_productt'interceding-token ngrams: SOCS1 . Whilet.interceding-token ngrams: domains with prolinetMe1: trigger-arg-path: binds >prep_to [lemma='vav'] theme:Gene_or_gene_productt#interceding-token ngrams: NcK , ITKtinterceding-token ngrams: , P85t.interceding-token ngrams: N-terminal domain oft+e1: args2Role-mention-ngram: the signallingtinterceding-token ngrams: NcKtQe2: trigger-arg-path: binding >prep_of [lemma='socs1'] theme:Gene_or_gene_productt!interceding-token ngrams: prolinet!interceding-token ngrams: , ITK ,tinterceding-token ngrams: FGHt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vav'] Gene_or_gene_productt#interceding-token ngrams: While thetSe2: trigger-arg-path: binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] themetNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs1'] themet5e1: args2Role-mention-ngram: the signalling moleculestOe1: trigger-arg-path: binds:Binding >prep_to [lemma='vav'] Gene_or_gene_productt!interceding-token ngrams: SOCS1 .t.e1: args2Role-mention-ngram: to the signallingtee2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] themet%interceding-token ngrams: . While thetce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='socs1'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] theme:Gene_or_gene_productt"interceding-token ngrams: , GRB2 ,tinterceding-token ngrams: P85 ,t7e1: args2Role-mention-ngram: signalling molecules THEMEt#interceding-token ngrams: their SH3tXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vav'] Gene_or_gene_productt$interceding-token ngrams: GRB2 , P85t%interceding-token ngrams: FGH throught2e1: ents2Label-mention-ngram: signalling moleculestje2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] Gene_or_gene_producttKe2: trigger-arg-path: binding >prep_of [lemma='socs1'] Gene_or_gene_producttGe1: trigger-arg-path: binds >prep_to [lemma='vav'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >prep_to [lemma='vav'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_to [lemma='vav'] theme:Gene_or_gene_producttprep_of [lemma='socs1'] themetQe2: trigger-arg-path: Binding >prep_of [lemma='socs1'] theme:Gene_or_gene_productt-interceding-token ngrams: through interactiont!interceding-token ngrams: and FGHt#interceding-token ngrams: ITK , andt+interceding-token ngrams: in the N-terminalt&interceding-token ngrams: domains witht,e1: ents2Label-mention-ngram: the signallingtDe2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] themetinterceding-token ngrams: NcK ,tIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vav'] themetKe2: trigger-arg-path: Binding >prep_of [lemma='socs1'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vav'] themet@e1: trigger-arg-path: binds:Binding >prep_to [lemma='vav'] themet+interceding-token ngrams: N-terminal domaintinterceding-token ngrams: SH3tinterceding-token ngrams: ITKtprep_of [lemma='socs1'] >prep_to [lemma='jak'] Gene_or_gene_productthe2: trigger-arg-path: Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] theme:Gene_or_gene_productt#interceding-token ngrams: , and FGHt+interceding-token ngrams: their SH3 domainst$CSSPATH: ROOT  ++ ROOT >advcl >nsubjt&e1: args2Role-mention-ngram: moleculestIe1: trigger-arg-path: Binding >prep_to [lemma='vav'] Gene_or_gene_producttinterceding-token ngrams: P85t&interceding-token ngrams: with prolinet interceding-token ngrams: , GRB2t,e1: args2Role-mention-ngram: molecules THEMEtpe2: trigger-arg-path: binding:Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] theme:Gene_or_gene_productt8e1: trigger-arg-path: binds >prep_to [lemma='vav'] themetee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='socs1'] Gene_or_gene_productt%interceding-token ngrams: SH3 domainst+interceding-token ngrams: proline motifs int$interceding-token ngrams: of SOCS1 .t!interceding-token ngrams: , P85 ,t/e1: ents2Label-mention-ngram: to the signallingtinterceding-token ngrams: , NcKtSe2: trigger-arg-path: Binding >prep_of [lemma='socs1'] >prep_to [lemma='jak'] themet'interceding-token ngrams: motifs in thet interceding-token ngrams: GRB2 ,tFtrigger-to-trigger-path: e1:interaction:Binding >nn e2:binding:BindingtXtrigger-to-trigger-path: e1:interaction:Binding >nn [lemma='binding'] e2:binding:Bindingt*e1: ents2Label-mention-ngram: dual GEF fort/e1: args2Role-mention-ngram: and interacts witht*e1: args2Role-mention-ngram: and interactstme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='grb2'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='sos1'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='sos1'] themet)e1: ents2Label-mention-ngram: GEF for Rastce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='sos1'] Gene_or_gene_producttNe1: trigger-arg-path: interacts >prep_with [lemma='grb2'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: for Ras andt?e1: trigger-arg-path: interacts >prep_with [lemma='grb2'] themet4e1: ents2Label-mention-ngram: adaptor protein SHAREDt-e1: args2Role-mention-ngram: with the adaptortge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='grb2'] Gene_or_gene_productt!e1: args2Role-mention-ngram: dualt*CSSPATH: ROOT >conj_and ++ ROOT >nsubjpasstNe1: trigger-arg-path: Binding >nsubj [lemma='sos1'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: and interacts witht e1: args2Role-mention-ngram: GEFt/e1: ents2Label-mention-ngram: Ras and interactst(e1: args2Role-mention-ngram: GEF for Rast'e1: ents2Label-mention-ngram: is a dualt(e1: args2Role-mention-ngram: for Ras andtinterceding-token ngrams: , Thet=e1: trigger-arg-path: Binding >prep_with [lemma='grb2'] themetCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='sos1'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='sos1'] themetGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='grb2'] themetee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='grb2'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: adaptor proteintPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='grb2'] themet\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='grb2'] theme:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='sos1'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='sos1'] themetXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='sos1'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='sos1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='sos1'] Gene_or_gene_productt)e1: args2Role-mention-ngram: dual GEF fort$e1: args2Role-mention-ngram: adaptort+e1: ents2Label-mention-ngram: and interactstTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='sos1'] themet)e1: ents2Label-mention-ngram: the adaptort$e1: ents2Label-mention-ngram: a dualtTe1: trigger-arg-path: interacts >prep_with [lemma='grb2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='grb2'] themet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='grb2'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: for Rast$e1: args2Role-mention-ngram: for RastJe1: trigger-arg-path: interacts >nsubj [lemma='sos1'] Gene_or_gene_producttVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='grb2'] Gene_or_gene_productt%e1: args2Role-mention-ngram: dual GEFt!e1: ents2Label-mention-ngram: GEFt"e1: ents2Label-mention-ngram: dualt!interceding-token ngrams: , , Thet1e1: ents2Label-mention-ngram: the adaptor proteint%e1: ents2Label-mention-ngram: adaptortinterceding-token ngrams: . , ,t'e1: args2Role-mention-ngram: a dual GEFt.e1: args2Role-mention-ngram: Ras and interactst0e1: args2Role-mention-ngram: the adaptor proteint#e1: args2Role-mention-ngram: a dualt(e1: args2Role-mention-ngram: the adaptort'interceding-tokens-full-span: . , , Thet.e1: ents2Label-mention-ngram: with the adaptortLe1: trigger-arg-path: Binding >prep_with [lemma='grb2'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: a dual GEFtPe1: trigger-arg-path: interacts >nsubj [lemma='sos1'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: adaptor protein THEMEtHe1: trigger-arg-path: Binding >nsubj [lemma='sos1'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: adaptor proteintRe1: trigger-arg-path: Binding >prep_with [lemma='grb2'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: GEF fort&e1: args2Role-mention-ngram: is a dualt%e1: ents2Label-mention-ngram: GEF fort&e1: ents2Label-mention-ngram: dual GEFtYe2: trigger-arg-path: Negative_activation >nsubj [lemma='sorafenib'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='src'] controlled:Gene_or_gene_productt interceding-token ngrams: in Bimt%interceding-token ngrams: correlatingtTe1: trigger-arg-path: inhibited:Negative_regulation >dobj controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt5e1: trigger-arg-path: inhibited >dobj PhosphorylationtHe2: trigger-arg-path: Negative_activation >dobj [lemma='src'] controlledtle1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='sorafenib'] Gene_or_gene_producttne1: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt%e1: ents2Label-mention-ngram: Src andt$e1: args2Role-mention-ngram: Src andt5e1: ents2Label-mention-ngram: sorafenib inhibited Srct1e1: ents2Label-mention-ngram: sorafenib inhibitedt@e1: trigger-arg-path: inhibited >dobj controlled:PhosphorylationtNe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='src'] controlledt e1: args2Role-mention-ngram: Srct,e1: ents2Label-mention-ngram: with sorafenibtGe2: trigger-arg-path: inhibits >dobj [lemma='src'] Gene_or_gene_productt)interceding-token ngrams: . The mechanismtSe1: trigger-arg-path: inhibited >nsubj >prep_of >nn controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='sorafenib'] Gene_or_gene_productt>e1: trigger-arg-path: inhibited >nsubj >prep_of >nn controllert~e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='sorafenib'] controller:Gene_or_gene_producttJe1: trigger-arg-path: inhibited >dobj [lemma='phosphorylation'] controlledt+interceding-token ngrams: in Bim expressiont?e1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt&interceding-token ngrams: mechanism bytye1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controllert=e2: trigger-arg-path: inhibits >dobj [lemma='src'] controlledtZe1: trigger-arg-path: inhibited >dobj [lemma='phosphorylation'] controlled:Phosphorylationtbe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of >nn controllertje2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='sorafenib'] controller:Gene_or_gene_producttNe2: trigger-arg-path: inhibits >nsubj [lemma='sorafenib'] Gene_or_gene_productt*interceding-token ngrams: Bim expression .tOe1: trigger-arg-path: inhibited >dobj [lemma='phosphorylation'] Phosphorylationt(interceding-token ngrams: Bim expressiont"interceding-token ngrams: by whicht-e1: args2Role-mention-ngram: CONTROLLER cellst?e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='src'] controlledt2e1: ents2Label-mention-ngram: cells with sorafenibt\e1: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of >nn Gene_or_gene_productt/e1: args2Role-mention-ngram: Src and CONTROLLEDt'interceding-token ngrams: The mechanismtce1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of >nn controller:Gene_or_gene_producttXe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='sorafenib'] controllertQe2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='src'] controlledt?e1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controllert)interceding-token ngrams: increase in Bimtge1: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: inhibited Srct]e2: trigger-arg-path: Negative_activation >dobj [lemma='src'] controlled:Gene_or_gene_productt0e1: args2Role-mention-ngram: sorafenib inhibitedt'interceding-token ngrams: , correlatingte1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controllert4e1: args2Role-mention-ngram: sorafenib inhibited Srct*interceding-token ngrams: The mechanism byt(e1: ents2Label-mention-ngram: cells witht1e1: args2Role-mention-ngram: cells with sorafenibtOe2: trigger-arg-path: Negative_activation >nsubj [lemma='sorafenib'] controllertce1: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationt6e1: ents2Label-mention-ngram: with sorafenib inhibitedt!e1: ents2Label-mention-ngram: Srct?e1: trigger-arg-path: inhibited >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of >nn controllert.e1: args2Role-mention-ngram: inhibited Src andtginterceding-tokens-full-span: , correlating with an increase in Bim expression . The mechanism by whichtHe1: trigger-arg-path: inhibited >nsubj >prep_of >nn Gene_or_gene_productt$CSSPATH: ROOT  ++ ROOT >nsubj >rcmodtfe2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='src'] controlled:Gene_or_gene_productt&e1: args2Role-mention-ngram: sorafenibt^e1: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='src'] Gene_or_gene_productt'e1: args2Role-mention-ngram: cells witht*interceding-token ngrams: correlating witht?e1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt,interceding-token ngrams: , correlating witht,interceding-token ngrams: mechanism by whicht5e1: args2Role-mention-ngram: with sorafenib inhibitedt0e1: trigger-arg-path: inhibited >dobj controlledtDe1: trigger-arg-path: inhibited:Negative_regulation >dobj controlledtXe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='src'] Gene_or_gene_productt[e2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='src'] Gene_or_gene_producttbe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='sorafenib'] Gene_or_gene_producttRe1: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of >nn controllert-interceding-token ngrams: correlating with antDe2: trigger-arg-path: inhibits >nsubj [lemma='sorafenib'] controllertYe2: trigger-arg-path: inhibits >nsubj [lemma='sorafenib'] controller:Gene_or_gene_producttme2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='sorafenib'] controller:Gene_or_gene_producttRe2: trigger-arg-path: inhibits >dobj [lemma='src'] controlled:Gene_or_gene_producttIe1: trigger-arg-path: inhibited:Negative_regulation >dobj Phosphorylationt+e1: args2Role-mention-ngram: with sorafenibtce2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='src'] controlled:Gene_or_gene_productt*interceding-token ngrams: expression . Thet/e1: ents2Label-mention-ngram: inhibited Src andt:e1: ents2Label-mention-ngram: Src and GENE_OR_GENE_PRODUCTt?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='sorafenib'] controllertXe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of >nn Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='sorafenib'] controllert*e1: args2Role-mention-ngram: inhibited SrctRe2: trigger-arg-path: Negative_activation >dobj [lemma='src'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT cells witht2e1: args2Role-mention-ngram: CONTROLLER cells witht'e1: ents2Label-mention-ngram: sorafenibtwe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of >nn controller:Gene_or_gene_producttoe1: trigger-arg-path: inhibited >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controllertFe1: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT phosphorylationtde2: trigger-arg-path: Negative_activation >nsubj [lemma='sorafenib'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] controllertye1: trigger-arg-path: inhibited >nsubj [lemma='treatment'] >prep_of [lemma='cell'] >nn [lemma='pc3'] Gene_or_gene_productt*interceding-token ngrams: with an increaset8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT cellst'interceding-token ngrams: for the firsttWe1: trigger-arg-path: Negative_activation >nsubj >appos controller:Gene_or_gene_productt interceding-token ngrams: to ERKt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt"interceding-token ngrams: displayst-interceding-token ngrams: only signaling fromt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controller:Gene_or_gene_productt3interceding-token ngrams: specificity comparable tot.interceding-token ngrams: that MCP110 disruptstLe1: trigger-arg-path: Negative_activation >nsubj >appos Gene_or_gene_productt#interceding-token ngrams: the firstt&interceding-token ngrams: but also thet.interceding-token ngrams: displays specificitytfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >appos Gene_or_gene_productt(e1: ents2Label-mention-ngram: not MCP146t!interceding-token ngrams: time wetde1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt&interceding-token ngrams: and displayst#e1: args2Role-mention-ngram: , alsotye1: trigger-arg-path: Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: MCP146t-interceding-token ngrams: MCP110 disrupts nottde1: trigger-arg-path: Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controllert*e1: args2Role-mention-ngram: MCP146 , alsot&interceding-token ngrams: ERK but alsotinterceding-token ngrams: -60t%e1: args2Role-mention-ngram: MCP146 ,t'e1: args2Role-mention-ngram: not MCP146t-e1: ents2Label-mention-ngram: , also inhibitstae1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt~e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controllert+interceding-token ngrams: disrupts not onlyt&interceding-token ngrams: time we showt!interceding-token ngrams: ERK buttne1: trigger-arg-path: Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] Gene_or_gene_productt0interceding-token ngrams: specificity comparablet[e1: trigger-arg-path: inhibits >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt$interceding-token ngrams: Ras to ERKt%interceding-token ngrams: specificityt\e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >appos controllert0interceding-token ngrams: signaling and displayst)interceding-token ngrams: MCP110 disruptstPe1: trigger-arg-path: inhibits >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt+interceding-token ngrams: -60 signaling andtKe1: trigger-arg-path: inhibits:Negative_activation >nsubj >appos controllert+interceding-token ngrams: cells that MCP110t]e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >appos controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='analog'] >appos [lemma='mcp116'] controllertinterceding-token ngrams: LETt*interceding-token ngrams: show evidence intle1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familyt!interceding-token ngrams: and LETt*interceding-token ngrams: we show evidencet+e1: args2Role-mention-ngram: but not MCP146t)e1: args2Role-mention-ngram: not MCP146 ,t$interceding-token ngrams: cells thatt'interceding-token ngrams: -60 signalingtBe1: trigger-arg-path: Negative_activation >nsubj >appos controllert&interceding-token ngrams: disrupts nott&e1: ents2Label-mention-ngram: MCP146 ,t+interceding-token ngrams: also the physicaltHe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >appos controllertAe1: trigger-arg-path: inhibits >nsubj >appos Gene_or_gene_producttTe1: trigger-arg-path: inhibits >dobj [lemma='signaling'] >nn [lemma='ra'] controlledtinterceding-token ngrams: , fort,interceding-token ngrams: not only signalingt$interceding-token ngrams: to ERK butt#interceding-token ngrams: to MCP110t(interceding-token ngrams: only signalingt.interceding-token ngrams: mammalian cells thatt'interceding-token ngrams: first time wet*interceding-token ngrams: MCP110 . Finallyt%interceding-token ngrams: from Ras tot%interceding-token ngrams: to MCP110 .t,interceding-token ngrams: signaling from Rast$interceding-token ngrams: first timette1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='analog'] >appos [lemma='mcp116'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: not MCP146 ,t%interceding-token ngrams: evidence int'interceding-token ngrams: signaling andtfe1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familytce1: trigger-arg-path: inhibits >nsubj [lemma='analog'] >appos [lemma='mcp116'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='analog'] >appos [lemma='mcp116'] controller:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >appos Gene_or_gene_productthe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt4CSSPATH: ROOT >ccomp ++ ROOT >dobj >rcmod >prep_fromtwe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] Gene_or_gene_productt.interceding-token ngrams: comparable to MCP110t'interceding-token ngrams: Finally , fortYe1: trigger-arg-path: inhibits >nsubj [lemma='analog'] >appos [lemma='mcp116'] controllert+e1: ents2Label-mention-ngram: MCP146 , alsot"interceding-token ngrams: from Rast9interceding-token ngrams: displays specificity comparablet[e1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familytye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt,e1: ents2Label-mention-ngram: but not MCP146t%interceding-token ngrams: that MCP110t7e1: trigger-arg-path: inhibits >nsubj >appos controllert_e1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlledt+interceding-token ngrams: LET -60 signalingt#interceding-token ngrams: , for thetue1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] Familyt/interceding-token ngrams: evidence in mammaliant$e1: ents2Label-mention-ngram: , alsotme1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controllert$e1: ents2Label-mention-ngram: MCP146t?interceding-tokens-full-span: and LET -60 signaling and displays specificity comparable to MCP110 . Finally , for the first time we show evidence in mammalian cells that MCP110 disrupts not only signaling from Ras to ERK but also the physicalt`e1: trigger-arg-path: inhibits:Negative_activation >nsubj >appos controller:Gene_or_gene_productt?e1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='analog'] >appos [lemma='mcp116'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='signaling'] >nn [lemma='ra'] controlledtUe1: trigger-arg-path: inhibits:Negative_activation >nsubj >appos Gene_or_gene_productt,e1: args2Role-mention-ngram: , also inhibitstne1: trigger-arg-path: inhibits >nsubj [lemma='analog'] >appos [lemma='mcp116'] controller:Gene_or_gene_productt!interceding-token ngrams: LET -60toe1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='signaling'] >nn [lemma='ra'] controlled:Familytqe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >appos controller:Gene_or_gene_productt"interceding-token ngrams: MCP110 .tLe1: trigger-arg-path: inhibits >nsubj >appos controller:Gene_or_gene_productt2interceding-token ngrams: and displays specificityt(interceding-token ngrams: signaling fromt%interceding-token ngrams: and LET -60t(interceding-token ngrams: the first timet'interceding-token ngrams: show evidencethe1: trigger-arg-path: phosphorylate nsubj [lemma='e'] >nn [lemma='cyclin'] Familyt!e1: args2Role-mention-ngram: CDK2tPe1: trigger-arg-path: phosphorylate:Positive_regulation nsubj >nn FamilytRe2: trigger-arg-path: inhibitor:Negative_activation nsubj [lemma='e'] >nn [lemma='cyclin'] controllert(e2: args2Role-mention-ngram: an upstreamt"interceding-token ngrams: of CDK 2t(interceding-token ngrams: steady loss int%e1: args2Role-mention-ngram: and CDK4t,interceding-token ngrams: fibroblasts ( MEFst?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controller:Familyt!interceding-token ngrams: loss int'interceding-token ngrams: , using mouset(interceding-tokens-full-span: , it is suspected that cyclin D and CDK4 is primarily responsible . In double-knockouts of CDK 2 and 4 , using mouse embryo fibroblasts ( MEFs ) , a steady loss in Rb phosphorylation was duly seen , resulting in decreased E2F target transcription , including that oft?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] Familyt*interceding-token ngrams: double-knockoutst"interceding-token ngrams: ( MEFs )tnsubj >nn Familyt-interceding-token ngrams: In double-knockoutstje2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation prep_of controlledt_e2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation nsubj >nn controllertMe1: trigger-arg-path: Positive_regulation nsubj >nn controller:Familyt>e2: trigger-arg-path: inhibitor nsubj >nn controller:FamilytDe2: trigger-arg-path: inhibitor nsubj [lemma='e'] >nn [lemma='cyclin'] Familyt#interceding-token ngrams: CDK 2 andte2: trigger: inhibitort'interceding-token ngrams: decreased E2Ft#interceding-token ngrams: 4 , usingt0interceding-token ngrams: resulting in decreasedtHe2: trigger-arg-path: inhibitor nsubj [lemma='e'] >nn [lemma='cyclin'] controllerte1: ents2Label-mention-ngram: Dt/e1: args2Role-mention-ngram: and CDK4 complexest1e2: ents2Label-mention-ngram: inhibitor of SHAREDt*interceding-token ngrams: , including thatt1interceding-token ngrams: primarily responsible .tye2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation nsubj >nn controllertne1: trigger-arg-path: Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] Familyt/e1: args2Role-mention-ngram: CDK4 complexes aretie2: trigger-arg-path: inhibitor:Negative_activation >prep_of [lemma='rb'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=inhibitor prep_of [lemma='rb'] controlled:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation prep_of controlledt interceding-token ngrams: ( MEFst"e2: args2Role-mention-ngram: be ante2: args2Role-mention-ngram: ant?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controller:Familyt$interceding-token ngrams: E2F targett3e2: ents2Label-mention-ngram: an upstream inhibitortbe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >nn Familyt%e2: args2Role-mention-ngram: upstreamt2interceding-token ngrams: E2F target transcriptiont+interceding-token ngrams: including that oft9e2: trigger-arg-path: inhibitor nsubj >nn controllertZe2: trigger-arg-path: lemmatizedTrigger=inhibitor prep_of Gene_or_gene_productt%interceding-token ngrams: fibroblaststEe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_of controlledt#interceding-token ngrams: suspectedt#e2: ents2Label-mention-ngram: be ant%interceding-token ngrams: and CDK4 ist"interceding-token ngrams: MEFs ) ,t,e1: ents2Label-mention-ngram: CDK4 complexestACSSPATH: ROOT >advcl >xcomp ++ ROOT >prep_including >prep_of >deptOe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_of Gene_or_gene_producttTe2: trigger-arg-path: Negative_activation >prep_of [lemma='rb'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controllert/e2: args2Role-mention-ngram: CONTROLLER ( whicht/interceding-token ngrams: in Rb phosphorylationt0e1: ents2Label-mention-ngram: and CDK4 complexest0e1: ents2Label-mention-ngram: CDK4 complexes aretRe2: trigger-arg-path: Negative_activation prep_of controlledt?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controllert,e2: ents2Label-mention-ngram: be an upstreamt!e1: args2Role-mention-ngram: CDK4t9e2: trigger-arg-path: Negative_activation prep_of controlled:Gene_or_gene_producttTe2: trigger-arg-path: inhibitor:Negative_activation >prep_of [lemma='rb'] controlledt_e2: trigger-arg-path: Negative_activation >prep_of [lemma='rb'] controlled:Gene_or_gene_productt0interceding-token ngrams: target transcription ,t(e2: args2Role-mention-ngram: ( which cant interceding-token ngrams: MEFs )t"e1: ents2Label-mention-ngram: CDK2t)e1: args2Role-mention-ngram: and cyclin Dt&interceding-token ngrams: is suspectedt2interceding-token ngrams: is primarily responsiblet4e2: args2Role-mention-ngram: inhibitor of CONTROLLEDt interceding-token ngrams: embryote1: args2Role-mention-ngram: Dt&e2: ents2Label-mention-ngram: upstreamt-e1: ents2Label-mention-ngram: FAMILY and CDK2tme1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj >nn controller:Familyt)e1: args2Role-mention-ngram: and CDK2 andt/e1: args2Role-mention-ngram: complexes are ablet[e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj >nn controller:Familytinterceding-token ngrams: in RbtRe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_of [lemma='rb'] controlledtBe1: trigger-arg-path: Positive_regulation nsubj >nn Familyt2interceding-token ngrams: phosphorylation was dulytHe2: trigger-arg-path: inhibitor >prep_of controlled:Gene_or_gene_productt interceding-token ngrams: steadytee2: trigger-arg-path: lemmatizedTrigger=inhibitor nsubj [lemma='e'] >nn [lemma='cyclin'] FamilytGe1: trigger-arg-path: phosphorylate nsubj >nn controller:Familyt/interceding-token ngrams: suspected that cyclint"interceding-token ngrams: was dulytinterceding-token ngrams: CDK 2t-interceding-token ngrams: double-knockouts oft!interceding-token ngrams: 2 and 4t0interceding-token ngrams: In double-knockouts oft,interceding-token ngrams: embryo fibroblastst]e2: trigger-arg-path: Negative_activation prep_of [lemma='rb'] Gene_or_gene_productt+interceding-token ngrams: CDK4 is primarilyt(e1: args2Role-mention-ngram: are able tot%interceding-token ngrams: using mouset?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='e'] >nn [lemma='cyclin'] controller:Familytne2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_of controlled:Gene_or_gene_productt/interceding-token ngrams: primarily responsiblet'e1: args2Role-mention-ngram: D and CDK4t"interceding-token ngrams: a steadyt$e2: args2Role-mention-ngram: ( whicht)e2: ents2Label-mention-ngram: an upstreamtse1: trigger-arg-path: phosphorylate nsubj [lemma='e'] >nn [lemma='cyclin'] controller:Familyt,interceding-token ngrams: Rb phosphorylationtQe2: trigger-arg-path: inhibitor:Negative_activation >prep_of Gene_or_gene_productt"e1: args2Role-mention-ngram: D andt^e2: trigger-arg-path: inhibitor:Negative_activation >prep_of [lemma='rb'] Gene_or_gene_productt.interceding-token ngrams: embryo fibroblasts (t\e2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_of [lemma='rb'] Gene_or_gene_producttJe2: trigger-arg-path: Negative_activation >prep_of [lemma='rb'] controlledt(e1: ents2Label-mention-ngram: D and CDK4t0e1: ents2Label-mention-ngram: complexes are ablet#e1: args2Role-mention-ngram: cyclint'interceding-token ngrams: that cyclin Dt3e2: ents2Label-mention-ngram: upstream inhibitor oftinterceding-token ngrams: 4tde2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation prep_of controlled:Gene_or_gene_productt)e1: args2Role-mention-ngram: cyclin D andtge2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_of [lemma='rb'] controlled:Gene_or_gene_productt*interceding-token ngrams: seen , resultingtre1: trigger-arg-path: Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controllertSe2: trigger-arg-path: inhibitor nsubj >nn controllertCe2: trigger-arg-path: Negative_activation prep_of Gene_or_gene_productt'e1: args2Role-mention-ngram: and cyclintJe2: trigger-arg-path: inhibitor >prep_of [lemma='rb'] Gene_or_gene_productt*interceding-token ngrams: in decreased E2Ft/e2: trigger-arg-path: inhibitor nsubj >nn Familyt0e1: args2Role-mention-ngram: CONTROLLER and CDK2tHe2: trigger-arg-path: Negative_activation prep_of [lemma='rb'] controlledt interceding-token ngrams: seen ,tye1: trigger-arg-path: Positive_regulation nsubj [lemma='e'] >nn [lemma='cyclin'] controller:FamilytCe2: trigger-arg-path: inhibitor:Negative_activation prep_of [lemma='rb'] controlled:Gene_or_gene_productt0interceding-token ngrams: Rb phosphorylation wast@e2: trigger-arg-path: inhibitor >prep_of [lemma='rb'] controlledtMe2: trigger-arg-path: inhibitor:Negative_activation nsubj >nn controllert%e1: args2Role-mention-ngram: CDK2 andt'interceding-token ngrams: fibroblasts (t'e2: args2Role-mention-ngram: targets oft0e2: ents2Label-mention-ngram: downstream targetst-interceding-token ngrams: inhibitory feedbackt'interceding-token ngrams: Merlin to PAKtZe2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] Gene_or_gene_productt/e2: args2Role-mention-ngram: downstream targetstKe2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] themet,e2: trigger-arg-path: targets >prep_of themet6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT aret interceding-token ngrams: Merlint&e2: args2Role-mention-ngram: THEME aret*e2: trigger-arg-path: targets >nsubj themetSe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] themet;e2: trigger-arg-path: targets >prep_of Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] themet1interceding-token ngrams: feedback mechanism fromtIe2: trigger-arg-path: targets:Binding >prep_of theme:Gene_or_gene_productt#interceding-token ngrams: Merlin tothe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] theme:Gene_or_gene_productt+interceding-token ngrams: also an importanttCe2: trigger-arg-path: targets:Binding >prep_of Gene_or_gene_productt,interceding-token ngrams: feedback mechanismt1interceding-token ngrams: an important inhibitorytLe2: trigger-arg-path: targets >prep_of [lemma='Merlin'] Gene_or_gene_producttAe2: trigger-arg-path: targets >prep_of theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: are downstreamt$interceding-token ngrams: is also ant3e2: ents2Label-mention-ngram: downstream targets oft:e2: trigger-arg-path: targets >nsubj [lemma='Group'] themet7interceding-token ngrams: important inhibitory feedbackt3e2: args2Role-mention-ngram: are downstream targetst/interceding-token ngrams: mechanism from Merlint(interceding-token ngrams: from Merlin totTe2: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] Gene_or_gene_producttEe2: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] themet7interceding-token ngrams: inhibitory feedback mechanismt+e2: args2Role-mention-ngram: are downstreamtOe2: trigger-arg-path: targets >nsubj [lemma='Group'] theme:Gene_or_gene_productt=e2: trigger-arg-path: targets >prep_of [lemma='Merlin'] themet'e2: args2Role-mention-ngram: downstreamt interceding-token ngrams: to PAKt?e2: trigger-arg-path: targets >nsubj theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_of [lemma='Merlin'] Gene_or_gene_productt-e2: args2Role-mention-ngram: targets of THEMEt'interceding-token ngrams: there is alsotce2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] theme:Gene_or_gene_productt.interceding-token ngrams: important inhibitoryte2: trigger: targetstZe2: trigger-arg-path: targets:Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: downstreamt$interceding-token ngrams: , there ist"interceding-token ngrams: to PAK .tRe2: trigger-arg-path: Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_producttRe2: trigger-arg-path: targets >prep_of [lemma='Merlin'] theme:Gene_or_gene_productt%interceding-token ngrams: from MerlintIe2: trigger-arg-path: targets >nsubj [lemma='Group'] Gene_or_gene_producttminterceding-tokens-full-span: , there is also an important inhibitory feedback mechanism from Merlin to PAK .t"interceding-token ngrams: feedbackt`e2: trigger-arg-path: lemmatizedTrigger=target >nsubj [lemma='Group'] theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: and inhibits SHAREDt9e2: trigger-arg-path: targets >nsubj Gene_or_gene_producttAe2: trigger-arg-path: targets:Binding >nsubj Gene_or_gene_productt!interceding-token ngrams: , theret!interceding-token ngrams: also antee2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='Group'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT are downstreamt]e2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] Gene_or_gene_producttWe2: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] theme:Gene_or_gene_producttQe2: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] Gene_or_gene_productt/e2: ents2Label-mention-ngram: targets of SHAREDtbe2: trigger-arg-path: lemmatizedTrigger=target:Binding >nsubj [lemma='Group'] Gene_or_gene_productt4e2: trigger-arg-path: targets:Binding >prep_of themet2e2: trigger-arg-path: targets:Binding >nsubj themet4e2: ents2Label-mention-ngram: are downstream targetst:e2: trigger-arg-path: Binding >nsubj [lemma='Group'] themetBe2: trigger-arg-path: targets:Binding >nsubj [lemma='Group'] themetGe2: trigger-arg-path: targets:Binding >nsubj theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_of [lemma='Merlin'] themetNe2: trigger-arg-path: lemmatizedTrigger=target >prep_of [lemma='Merlin'] themet1e2: args2Role-mention-ngram: THEME are downstreamt2e2: args2Role-mention-ngram: downstream targets oftke2: trigger-arg-path: lemmatizedTrigger=target:Binding >prep_of [lemma='Merlin'] theme:Gene_or_gene_productt(interceding-token ngrams: mechanism fromt(e2: ents2Label-mention-ngram: targets oftOe2: trigger-arg-path: Binding >nsubj [lemma='Group'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlled:Gene_or_gene_productt$interceding-token ngrams: cell cycletNe2: trigger-arg-path: activated >nsubjpass >nn controlled:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='overexpression'] >nn [lemma='her2'] Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=activate >agent >nn controllert-e2: args2Role-mention-ngram: promoter is alsotJe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn controlledtde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn Gene_or_gene_productt]e2: trigger-arg-path: activated >agent [lemma='overexpression'] >nn [lemma='her2'] controllertfinterceding-tokens-full-span: promoter and induces cell cycle arrest in an Arf dependent fashion . Thetoe2: trigger-arg-path: Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn controllert[e2: trigger-arg-path: lemmatizedTrigger=activate >agent >nn controller:Gene_or_gene_producttinterceding-token ngrams: cyclet/e1: args2Role-mention-ngram: directly binds andt[e2: trigger-arg-path: activated >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlledt|e2: trigger-arg-path: Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controller:Gene_or_gene_productt%interceding-token ngrams: and inducestNe1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themet.e2: args2Role-mention-ngram: is also activatedt3e2: args2Role-mention-ngram: CONTROLLED promoter ist?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='overexpression'] >nn [lemma='her2'] controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] FamilytUe1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familyt*interceding-token ngrams: an Arf dependenttge2: trigger-arg-path: Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controllertle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:FamilytSe2: trigger-arg-path: activated:Positive_activation >agent >nn Gene_or_gene_productt&interceding-token ngrams: arrest in ant,interceding-token ngrams: induces cell cycletoe2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlledtSe1: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familytse2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_productt'interceding-token ngrams: Arf dependentt0e1: ents2Label-mention-ngram: directly binds andtpe2: trigger-arg-path: activated >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlled:Gene_or_gene_productt2e1: ents2Label-mention-ngram: activates the FAMILYt&interceding-token ngrams: cycle arresttle2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlledtWe2: trigger-arg-path: activated:Positive_activation >nsubjpass >nn Gene_or_gene_productt,e2: ents2Label-mention-ngram: also activatedt0e2: args2Role-mention-ngram: CONTROLLED promotert/e2: ents2Label-mention-ngram: is also activatedtze2: trigger-arg-path: Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlled:Gene_or_gene_producttqe2: trigger-arg-path: Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] Gene_or_gene_productt+e2: args2Role-mention-ngram: also activatedt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controller:Gene_or_gene_productt/interceding-token ngrams: Arf dependent fashiontde1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familyt)e2: ents2Label-mention-ngram: promoter istMe2: trigger-arg-path: activated:Positive_activation >nsubjpass >nn controlledt{e2: trigger-arg-path: activated:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] FamilytMe2: trigger-arg-path: Positive_activation >nsubjpass >nn Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn controlled:Gene_or_gene_producttXe2: trigger-arg-path: Positive_activation >nsubjpass >nn controlled:Gene_or_gene_producttMe1: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt'interceding-token ngrams: fashion . Thet?e2: trigger-arg-path: activated:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controller:Gene_or_gene_producttee2: trigger-arg-path: activated >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn controller:Gene_or_gene_producttbe2: trigger-arg-path: activated:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_producttinterceding-token ngrams: Arftye2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] Gene_or_gene_productt?e2: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlled:Gene_or_gene_productt1e1: ents2Label-mention-ngram: binds and activatest#interceding-token ngrams: arrest int(e2: args2Role-mention-ngram: promoter ist.interceding-token ngrams: promoter and inducest)interceding-token ngrams: cycle arrest intUe1: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] FamilytOe1: trigger-arg-path: Binding >dobj [lemma='promoter'] >nn [lemma='arf'] Familyt interceding-token ngrams: an Arft0e2: ents2Label-mention-ngram: SHARED promoter ist*interceding-token ngrams: and induces cellt.e2: args2Role-mention-ngram: also activated bytre2: trigger-arg-path: activated >agent [lemma='overexpression'] >nn [lemma='her2'] controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='promoter'] >nn [lemma='arf'] themetCe2: trigger-arg-path: activated >nsubjpass >nn Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themet?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controllertve2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] Gene_or_gene_producttge2: trigger-arg-path: activated >agent [lemma='overexpression'] >nn [lemma='her2'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='overexpression'] >nn [lemma='her2'] controllert9e2: trigger-arg-path: activated >nsubjpass >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn controlledt[e1: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] theme:Familythe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass >nn Gene_or_gene_productt+interceding-token ngrams: dependent fashiontTe2: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass >nn Gene_or_gene_productt-interceding-token ngrams: dependent fashion .t?e2: trigger-arg-path: activated >agent >nn Gene_or_gene_producttLe1: trigger-arg-path: binds >dobj [lemma='promoter'] >nn [lemma='arf'] themetTe1: trigger-arg-path: binds:Binding >dobj [lemma='promoter'] >nn [lemma='arf'] themet.e2: ents2Label-mention-ngram: promoter is alsot0e1: args2Role-mention-ngram: binds and activatest#interceding-token ngrams: in an Arft5e2: trigger-arg-path: activated >agent >nn controllertqe2: trigger-arg-path: activated:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] controllertPe2: trigger-arg-path: lemmatizedTrigger=activate >agent >nn Gene_or_gene_productt/e2: ents2Label-mention-ngram: also activated byt^e2: trigger-arg-path: activated:Positive_activation >agent >nn controller:Gene_or_gene_productt%CSSPATH: ROOT >dep >prepc_in ++ ROOT t&interceding-token ngrams: induces cellt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlledt+interceding-token ngrams: cell cycle arresttIe2: trigger-arg-path: activated:Positive_activation >agent >nn controllertJe2: trigger-arg-path: activated >agent >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='overexpression'] >nn [lemma='her2'] Gene_or_gene_producttee2: trigger-arg-path: Positive_activation >nsubjpass [lemma='promoter'] >nn [lemma='dmp1'] controlledtAe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf2'] themetLe2: trigger-arg-path: interacts >nsubj [lemma='rassf2'] Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='k-ra'] Gene_or_gene_productt1interceding-token ngrams: Two-hybrid screens havetne2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nore1'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf2'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='k-ra'] theme:Gene_or_gene_productt interceding-token ngrams: , onlyt*e2: args2Role-mention-ngram: interacts andtinterceding-token ngrams: RAt interceding-token ngrams: the RAt&interceding-token ngrams: screens havetVe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt/interceding-token ngrams: only weakly interactst$interceding-token ngrams: Two-hybridtge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='k-ra'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='k-ra'] Gene_or_gene_productt!interceding-token ngrams: H-Ras .tJe1: trigger-arg-path: Binding >prep_to [lemma='k-ra'] Gene_or_gene_productt%interceding-token ngrams: only weaklyt$interceding-token ngrams: via the RAtAe1: trigger-arg-path: binds:Binding >prep_to [lemma='k-ra'] themetYe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nore1'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='k-ra'] themet.interceding-token ngrams: . Two-hybrid screenstYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='k-ra'] Gene_or_gene_productt0e2: args2Role-mention-ngram: and associates withtUe2: trigger-arg-path: interacts >prep_with [lemma='nore1'] theme:Gene_or_gene_producttinterceding-token ngrams: havet+e2: ents2Label-mention-ngram: interacts andt@e2: trigger-arg-path: interacts >prep_with [lemma='nore1'] themet.interceding-token ngrams: dependent manner viat,e2: ents2Label-mention-ngram: and associatest+e2: args2Role-mention-ngram: and associatestPe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf2'] Gene_or_gene_productt!interceding-token ngrams: via thet(interceding-token ngrams: manner via thet?interceding-tokens-full-span: in a GTP dependent manner via the RA domain , however , only weakly interacts with H-Ras . Two-hybrid screens have found thatt#interceding-token ngrams: RA domaint9e1: trigger-arg-path: binds >nsubj [lemma='rassf2'] themetVe1: trigger-arg-path: binds:Binding >prep_to [lemma='k-ra'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >prep_with [lemma='nore1'] Gene_or_gene_productt%interceding-token ngrams: RA domain ,tSe2: trigger-arg-path: Binding >prep_with [lemma='nore1'] theme:Gene_or_gene_productt$interceding-token ngrams: with H-Rast]e2: trigger-arg-path: interacts:Binding >prep_with [lemma='nore1'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf2'] Gene_or_gene_productt/e2: args2Role-mention-ngram: also interacts andtNe1: trigger-arg-path: binds >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nore1'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf2'] themetPe2: trigger-arg-path: Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: interacts and associatestRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf2'] themetPe1: trigger-arg-path: binds:Binding >prep_to [lemma='k-ra'] Gene_or_gene_producttZe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt'interceding-token ngrams: , only weaklyt/interceding-token ngrams: weakly interacts withtWe2: trigger-arg-path: interacts:Binding >prep_with [lemma='nore1'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nore1'] themet]e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf2'] Gene_or_gene_productt,interceding-token ngrams: H-Ras . Two-hybridt9e1: trigger-arg-path: binds >prep_to [lemma='k-ra'] themet>e2: trigger-arg-path: Binding >prep_with [lemma='nore1'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf2'] themet0e2: ents2Label-mention-ngram: also interacts andt"interceding-token ngrams: domain ,tge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='k-ra'] theme:Gene_or_gene_productt5e2: args2Role-mention-ngram: interacts and associatestce2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt&interceding-token ngrams: with H-Ras .tPe1: trigger-arg-path: Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_producttHe2: trigger-arg-path: interacts:Binding >prep_with [lemma='nore1'] themetVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf2'] themet,interceding-token ngrams: screens have foundtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf2'] Gene_or_gene_producttOe2: trigger-arg-path: interacts >prep_with [lemma='nore1'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='rassf2'] Gene_or_gene_productt$interceding-token ngrams: manner viat)interceding-token ngrams: have found thattfe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nore1'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nore1'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >nsubj [lemma='rassf2'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: directly to GENE_OR_GENE_PRODUCTtHe1: trigger-arg-path: binds >nsubj [lemma='rassf2'] Gene_or_gene_productt,interceding-token ngrams: Two-hybrid screenst(interceding-token ngrams: however , onlyt=e2: trigger-arg-path: interacts >nsubj [lemma='rassf2'] themetke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf2'] theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >nsubj [lemma='rassf2'] themet1e2: ents2Label-mention-ngram: and associates witht$interceding-token ngrams: have foundt'interceding-token ngrams: the RA domaint;e1: trigger-arg-path: Binding >nsubj [lemma='rassf2'] themetRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='k-ra'] themet.interceding-token ngrams: interacts with H-RastYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf2'] Gene_or_gene_productt*interceding-token ngrams: weakly interactstEe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf2'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='k-ra'] themet*interceding-token ngrams: domain , howevert&interceding-token ngrams: . Two-hybridtRe2: trigger-arg-path: interacts >nsubj [lemma='rassf2'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds >prep_to [lemma='k-ra'] theme:Gene_or_gene_productt interceding-token ngrams: to ca.t)interceding-token ngrams: did not inhibitt!interceding-token ngrams: 50 % oft#interceding-token ngrams: to ca. 50tee2: trigger-arg-path: induced:Positive_activation ccomp ++ ROOT >advcl >dobj >vmodtinterceding-token ngrams: a PKCt*interceding-token ngrams: inhibitor Go6983tPe2: trigger-arg-path: induced:Positive_activation prep_to [lemma='er'] themet;e1: trigger-arg-path: activated >nsubj Gene_or_gene_producttinterceding-token ngrams: ERE )t=e2: trigger-arg-path: Binding >nsubj [lemma='estrogen'] themetje1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='element'] >nn [lemma='estrogen'] controlledt&interceding-token ngrams: estrogen andtKe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj Simple_chemicaltFe2: trigger-arg-path: binds >prep_to [lemma='er'] Gene_or_gene_productt:e2: trigger-arg-path: binds:Binding >nsubj Simple_chemicalthe1: trigger-arg-path: Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] Simple_chemicalt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='er'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='eralpha'] controllertMe2: trigger-arg-path: binds:Binding >nsubj [lemma='estrogen'] Simple_chemicaltTe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='eralpha'] controllertie1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='eralpha'] controller:Gene_or_gene_productt:e2: trigger-arg-path: Binding >nsubj theme:Simple_chemicaltie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn controlled:Simple_chemicalt'interceding-token ngrams: element ( EREtHe2: trigger-arg-path: Binding >prep_to [lemma='er'] Gene_or_gene_productt!interceding-token ngrams: and aretWe1: trigger-arg-path: activated:Positive_activation >nsubj [lemma='eralpha'] controllertse1: trigger-arg-path: Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlled:Simple_chemicalt6interceding-token ngrams: inhibited with anti-estrogent#e1: args2Role-mention-ngram: ERbetatKe2: trigger-arg-path: binds >nsubj [lemma='estrogen'] theme:Simple_chemicaltCe2: trigger-arg-path: binds:Binding >nsubj [lemma='estrogen'] themetSe2: trigger-arg-path: binds:Binding >nsubj [lemma='estrogen'] theme:Simple_chemicaltFe1: trigger-arg-path: activated >nsubj controller:Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='estrogen'] Simple_chemicalt"interceding-token ngrams: ERE ) intinterceding-token ngrams: ( EREt(e1: ents2Label-mention-ngram: and ERbetat]e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='er'] theme:Gene_or_gene_productt)interceding-token ngrams: to estrogen andtle1: trigger-arg-path: activated:Positive_activation >nsubj [lemma='eralpha'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: ERbeta activatedtUe1: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn controlled:Simple_chemicalt+interceding-token ngrams: and are inhibitedt5e1: ents2Label-mention-ngram: ERbeta activated SHAREDt,interceding-token ngrams: are inhibited withtDe1: trigger-arg-path: activated >dobj >nn controlled:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] Simple_chemicalt.interceding-token ngrams: with anti-estrogen .t'e1: args2Role-mention-ngram: and ERbetatGe2: trigger-arg-path: Binding >nsubj [lemma='estrogen'] Simple_chemicaltCe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlled:Simple_chemicaltCe1: trigger-arg-path: activated >nsubj [lemma='eralpha'] controllertEe1: trigger-arg-path: activated:Positive_activation >nsubj controllert^e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn Simple_chemicaltWe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='er'] Gene_or_gene_producttbe1: trigger-arg-path: Positive_activation >nsubj [lemma='eralpha'] controller:Gene_or_gene_productt^e1: trigger-arg-path: activated >dobj [lemma='element'] >nn [lemma='estrogen'] Simple_chemicaltEe1: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn controlledt,interceding-token ngrams: response element (tYe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj >nn controlledt}e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='eralpha'] controller:Gene_or_gene_producttMe1: trigger-arg-path: Positive_activation >nsubj [lemma='eralpha'] controllert^e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='eralpha'] Gene_or_gene_productt2e2: trigger-arg-path: binds >nsubj Simple_chemicalt'interceding-token ngrams: anti-estrogentCe1: trigger-arg-path: Positive_activation >dobj >nn Simple_chemicaltXe1: trigger-arg-path: activated:Positive_activation >dobj >nn controlled:Simple_chemicalt}e1: trigger-arg-path: activated:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlled:Simple_chemicaltXe1: trigger-arg-path: activated >nsubj [lemma='eralpha'] controller:Gene_or_gene_producttNe2: trigger-arg-path: Binding >prep_to [lemma='er'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='er'] theme:Gene_or_gene_productt*interceding-token ngrams: response elementt-e1: args2Role-mention-ngram: ERbeta activatedtde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='estrogen'] theme:Simple_chemicaltze1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='element'] >nn [lemma='estrogen'] controlled:Simple_chemicaltMe1: trigger-arg-path: activated:Positive_activation >dobj >nn Simple_chemicalt^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='estrogen'] Simple_chemicalt'interceding-token ngrams: ) in responsetNe2: trigger-arg-path: binds:Binding >prep_to [lemma='er'] Gene_or_gene_productt%interceding-token ngrams: to estrogentoe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='element'] >nn [lemma='estrogen'] Simple_chemicalt9e2: trigger-arg-path: Binding >prep_to [lemma='er'] themetJe1: trigger-arg-path: lemmatizedTrigger=activate >dobj >nn Simple_chemicalt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='estrogen'] theme:Simple_chemicaltMe1: trigger-arg-path: activated >nsubj [lemma='eralpha'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='eralpha'] Gene_or_gene_producttae1: trigger-arg-path: activated:Positive_activation >nsubj [lemma='eralpha'] Gene_or_gene_productt,interceding-token ngrams: with anti-estrogentWe1: trigger-arg-path: Positive_activation >nsubj [lemma='eralpha'] Gene_or_gene_producttme1: trigger-arg-path: activated:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlledt2e1: args2Role-mention-ngram: CONTROLLER and ERbetatre1: trigger-arg-path: activated:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] Simple_chemicaltuinterceding-tokens-full-span: response element ( ERE ) in response to estrogen and are inhibited with anti-estrogen .t(interceding-token ngrams: inhibited witht!interceding-token ngrams: elementt2e1: ents2Label-mention-ngram: and ERbeta activatedt!interceding-token ngrams: ( ERE )tVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='estrogen'] Simple_chemicaltce1: trigger-arg-path: Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlledtHe1: trigger-arg-path: activated:Positive_activation >dobj >nn controlledt8e2: trigger-arg-path: binds >nsubj theme:Simple_chemicalt8e1: args2Role-mention-ngram: ERbeta activated CONTROLLEDt)interceding-token ngrams: anti-estrogen .t~e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='element'] >nn [lemma='estrogen'] controlledtPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='er'] themetNe1: trigger-arg-path: Positive_activation >dobj >nn controlled:Simple_chemicalt/e1: ents2Label-mention-ngram: SHARED and ERbetatinterceding-token ngrams: EREtYe1: trigger-arg-path: activated >dobj [lemma='element'] >nn [lemma='estrogen'] controlledtTe2: trigger-arg-path: binds:Binding >prep_to [lemma='er'] theme:Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding >prep_to [lemma='er'] themetMe2: trigger-arg-path: Binding >nsubj [lemma='estrogen'] theme:Simple_chemicaltIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj theme:Simple_chemicalt'interceding-token ngrams: are inhibitedt$e1: ents2Label-mention-ngram: ERbetat@e2: trigger-arg-path: binds:Binding >nsubj theme:Simple_chemicalt9e1: trigger-arg-path: activated >dobj >nn Simple_chemicaltLe2: trigger-arg-path: binds >prep_to [lemma='er'] theme:Gene_or_gene_productt#interceding-token ngrams: element (tinterceding-token ngrams: ) intZe1: trigger-arg-path: activated:Positive_activation >nsubj controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='estrogen'] themet1e1: args2Role-mention-ngram: and ERbeta activatedtie1: trigger-arg-path: activated >dobj [lemma='element'] >nn [lemma='estrogen'] controlled:Simple_chemicalt.interceding-token ngrams: response to estrogentHe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='er'] themet"interceding-token ngrams: estrogentQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj theme:Simple_chemicaltOe1: trigger-arg-path: activated:Positive_activation >nsubj Gene_or_gene_productt*interceding-token ngrams: estrogen and aret4e1: trigger-arg-path: activated >dobj >nn controlledtLe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='estrogen'] themet;e2: trigger-arg-path: binds >nsubj [lemma='estrogen'] themet4e2: trigger-arg-path: Binding >nsubj Simple_chemicalt3interceding-token ngrams: survivin ubiquitination .t"interceding-token ngrams: catalyzet+interceding-token ngrams: catalyze survivintEe2: trigger-arg-path: complex >nn [lemma='xaf1'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xaf1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xaf1'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xaf1'] Gene_or_gene_productt$interceding-token ngrams: ) activityt+interceding-token ngrams: ubiquitin proteint>e2: trigger-arg-path: complex:Binding >nn [lemma='xaf1'] themetNe1: trigger-arg-path: Binding >nsubj [lemma='xaf1'] theme:Gene_or_gene_productt+interceding-token ngrams: activates XIAP 'stinterceding-token ngrams: E3 )t3interceding-token ngrams: protein isopeptide ligaset6e2: trigger-arg-path: Binding >nn [lemma='xaf1'] themet4interceding-token ngrams: and subsequently activatestHe1: trigger-arg-path: binds >prep_to [lemma='xiap'] Gene_or_gene_productt!interceding-token ngrams: XIAP 'stEe2: trigger-arg-path: Binding >nn [lemma='xaf1'] Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >prep_to [lemma='xiap'] theme:Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='xiap'] Gene_or_gene_productt interceding-token ngrams: ( E3 )tae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='xiap'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xiap'] theme:Gene_or_gene_productt5interceding-token ngrams: subsequently activates XIAPtAe1: trigger-arg-path: binds:Binding >prep_to [lemma='xiap'] themet;e1: trigger-arg-path: Binding >prep_to [lemma='xiap'] themet?interceding-tokens-full-span: and subsequently activates XIAP 's ubiquitin protein isopeptide ligase ( E3 ) activity to catalyze survivin ubiquitination . Activation of HER2 and ERK was shown to reduce the formation of thetPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='xaf1'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xaf1'] themet1interceding-token ngrams: survivin ubiquitinationtJe1: trigger-arg-path: Binding >prep_to [lemma='xiap'] Gene_or_gene_producttSe2: trigger-arg-path: complex:Binding >nn [lemma='xiap'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='xaf1'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xaf1'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='xiap'] theme:Gene_or_gene_producttinterceding-token ngrams: ( E3tKe2: trigger-arg-path: complex >nn [lemma='xiap'] theme:Gene_or_gene_productt+interceding-token ngrams: isopeptide ligaset'interceding-token ngrams: ) activity totKe2: trigger-arg-path: Binding >nn [lemma='xiap'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='xaf1'] themet+interceding-token ngrams: XIAP 's ubiquitint-interceding-token ngrams: isopeptide ligase (tSe2: trigger-arg-path: complex:Binding >nn [lemma='xaf1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='xiap'] Gene_or_gene_productt.interceding-token ngrams: to catalyze survivintHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xiap'] themetNe1: trigger-arg-path: binds:Binding >nsubj [lemma='xaf1'] Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='xaf1'] theme:Gene_or_gene_productt0interceding-token ngrams: subsequently activatestNe1: trigger-arg-path: binds >prep_to [lemma='xiap'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='xaf1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='xiap'] theme:Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='xiap'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='xaf1'] Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='xaf1'] Gene_or_gene_productt9e1: trigger-arg-path: binds >prep_to [lemma='xiap'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='xaf1'] theme:Gene_or_gene_productt,interceding-token ngrams: protein isopeptidet$interceding-token ngrams: isopeptidetPe1: trigger-arg-path: Binding >prep_to [lemma='xiap'] theme:Gene_or_gene_productt*interceding-token ngrams: ubiquitination .tMe2: trigger-arg-path: complex:Binding >nn [lemma='xiap'] Gene_or_gene_productt%interceding-token ngrams: ligase ( E3t%interceding-token ngrams: activity tot>e2: trigger-arg-path: complex:Binding >nn [lemma='xiap'] themetFe1: trigger-arg-path: binds >nsubj [lemma='xaf1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='xaf1'] theme:Gene_or_gene_productt.interceding-token ngrams: activity to catalyzetTe1: trigger-arg-path: binds:Binding >nsubj [lemma='xaf1'] theme:Gene_or_gene_productt:interceding-token ngrams: catalyze survivin ubiquitinationt5interceding-token ngrams: ubiquitination . ActivationtLe1: trigger-arg-path: binds >nsubj [lemma='xaf1'] theme:Gene_or_gene_productt&interceding-token ngrams: 's ubiquitint'interceding-token ngrams: E3 ) activitytWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xiap'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='xaf1'] themetPe1: trigger-arg-path: binds:Binding >prep_to [lemma='xiap'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xiap'] Gene_or_gene_productt7e1: trigger-arg-path: binds >nsubj [lemma='xaf1'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='xiap'] themet%interceding-token ngrams: to catalyzet6interceding-token ngrams: ubiquitin protein isopeptidetEe2: trigger-arg-path: complex >nn [lemma='xiap'] Gene_or_gene_productt(interceding-token ngrams: activates XIAPt.interceding-token ngrams: 's ubiquitin proteintPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='xiap'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xaf1'] themet6e2: trigger-arg-path: complex >nn [lemma='xiap'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='xaf1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='xiap'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='xiap'] themet,CSSPATH: ROOT  ++ ROOT >xcomp >dobj >prep_oft?e1: trigger-arg-path: binds:Binding >nsubj [lemma='xaf1'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='xaf1'] themet'e2: args2Role-mention-ngram: the wt Rast0e1: ents2Label-mention-ngram: enhancement of thetce1: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: wt Rast(e1: args2Role-mention-ngram: enhancementtxe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_producttie2: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt)e2: args2Role-mention-ngram: wt Ras boundt#e1: ents2Label-mention-ngram: on wtt,e2: ents2Label-mention-ngram: an enhancementt$e1: args2Role-mention-ngram: that istce2: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt.e2: args2Role-mention-ngram: is an enhancementt+e2: args2Role-mention-ngram: an enhancementt"e2: args2Role-mention-ngram: on wtt"e1: args2Role-mention-ngram: on wtt"e2: args2Role-mention-ngram: is antae1: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_producttZe1: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet.e1: args2Role-mention-ngram: an enhancement oft,e1: ents2Label-mention-ngram: enhancement oft)e2: ents2Label-mention-ngram: wt Ras thatt#e2: ents2Label-mention-ngram: on wttie1: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: is ant'e2: ents2Label-mention-ngram: on wt Rast&e1: args2Role-mention-ngram: on wt Rast&e2: args2Role-mention-ngram: on wt Rast(e1: ents2Label-mention-ngram: the wt Rast#e1: args2Role-mention-ngram: wt Rastae2: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt(e2: args2Role-mention-ngram: wt Ras thatt(e1: args2Role-mention-ngram: Ras that istze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: enhancement of thet/e2: ents2Label-mention-ngram: is an enhancementt'e1: ents2Label-mention-ngram: of the wtt#e2: args2Role-mention-ngram: wt Rast'e1: args2Role-mention-ngram: the wt Rast)e1: args2Role-mention-ngram: wt Ras boundt/e2: args2Role-mention-ngram: enhancement of thet.e1: args2Role-mention-ngram: is an enhancementtge2: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_producttie2: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: wt Ras thatt(e1: args2Role-mention-ngram: THEME on wtt+e1: args2Role-mention-ngram: an enhancementtRe2: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet'e2: ents2Label-mention-ngram: Ras boundt.e2: ents2Label-mention-ngram: Ras bound SHAREDtTe2: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet(e2: ents2Label-mention-ngram: that is ant+e2: args2Role-mention-ngram: enhancement oftge1: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: enhancement oft)e2: ents2Label-mention-ngram: enhancementt*e1: ents2Label-mention-ngram: SHARED on wtt'e2: args2Role-mention-ngram: that is ant'e1: ents2Label-mention-ngram: on wt Rastxe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: an enhancement oft?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: Ras boundt*e2: ents2Label-mention-ngram: SHARED on wtt*e1: ents2Label-mention-ngram: wt Ras boundt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: Ras boundtre2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_producttTe1: trigger-arg-path: Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet,e1: args2Role-mention-ngram: Ras bound THEMEt%e2: args2Role-mention-ngram: Ras thatt(e1: args2Role-mention-ngram: wt Ras thattre1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt.e2: args2Role-mention-ngram: an enhancement oft)e2: ents2Label-mention-ngram: Ras that ist(e1: ents2Label-mention-ngram: that is antke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet(e2: args2Role-mention-ngram: enhancementt/e1: ents2Label-mention-ngram: is an enhancementt)e1: ents2Label-mention-ngram: enhancementtie1: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] Gene_or_gene_productt%e1: args2Role-mention-ngram: Ras thatt+e1: args2Role-mention-ngram: enhancement oftRe1: trigger-arg-path: bound >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet(e2: args2Role-mention-ngram: Ras that ist,e2: args2Role-mention-ngram: Ras bound THEMEt*e2: ents2Label-mention-ngram: wt Ras boundt/e1: args2Role-mention-ngram: enhancement of thet&e1: ents2Label-mention-ngram: Ras thatt&e2: ents2Label-mention-ngram: Ras thatt'e1: args2Role-mention-ngram: that is antoe2: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_producttZe2: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themetke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet/e2: ents2Label-mention-ngram: an enhancement oft'e1: ents2Label-mention-ngram: Ras boundt.e1: ents2Label-mention-ngram: Ras bound SHAREDtce1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themetoe1: trigger-arg-path: bound:Binding >nsubj [lemma='action'] >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: of the wtt&e2: args2Role-mention-ngram: of the wtt(e2: ents2Label-mention-ngram: the wt Rast)e1: ents2Label-mention-ngram: Ras that ist(e2: args2Role-mention-ngram: THEME on wtt'e2: ents2Label-mention-ngram: of the wttce2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='action'] >prep_of [lemma='cdc25'] themet$e1: ents2Label-mention-ngram: wt Rast,e1: ents2Label-mention-ngram: an enhancementt#e1: ents2Label-mention-ngram: is ant"e1: args2Role-mention-ngram: is ant[e1: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controllert#interceding-token ngrams: occlusiontJe2: trigger-arg-path: Positive_activation >nsubj [lemma='this'] controllertme1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controllert interceding-token ngrams: tail .tde2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='this'] controllertze2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt(interceding-token ngrams: preventing thet'interceding-token ngrams: by preventingtde2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj controller:Generic_entityt)interceding-token ngrams: the DNA bindingt?e1: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controller:Gene_or_gene_producttSe2: trigger-arg-path: enhances:Positive_activation >nsubj controller:Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controller:Gene_or_gene_productt?interceding-tokens-full-span: and CBP and PCAF promotes an open conformation of p53 by preventing the occlusion of the DNA binding domain by the C-terminal tail .tPe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='this'] controllertCe2: trigger-arg-path: enhances >nsubj [lemma='this'] Generic_entityt)interceding-token ngrams: conformation oft?e2: trigger-arg-path: enhances >nsubj [lemma='this'] controllerthe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='this'] Generic_entityt*interceding-token ngrams: occlusion of thet}e2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttYe2: trigger-arg-path: Positive_activation >nsubj [lemma='this'] controller:Generic_entitytYe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj Generic_entityt"interceding-token ngrams: and PCAFtye2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt>e1: trigger-arg-path: acetylation >prep_of >prep_by controllert&interceding-token ngrams: occlusion oft+interceding-token ngrams: by the C-terminalt#interceding-token ngrams: domain bytpe1: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controller:Gene_or_gene_producttHe1: trigger-arg-path: acetylation >prep_of >prep_by Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controller:Generic_entitytge1: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by controller:Gene_or_gene_productt+interceding-token ngrams: and PCAF promotest4e2: trigger-arg-path: enhances >nsubj Generic_entityt!interceding-token ngrams: CBP andtRe1: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by controllertxe1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controller:Gene_or_gene_productt&interceding-token ngrams: CBP and PCAFt?e2: trigger-arg-path: enhances >nsubj controller:Generic_entityt;e2: args2Role-mention-ngram: CONTROLLER enhances CONTROLLEDt+interceding-token ngrams: open conformationt*interceding-token ngrams: the occlusion oft?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controllert^e2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt+interceding-token ngrams: C-terminal tail .toe1: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controllert-interceding-token ngrams: conformation of p53tee1: trigger-arg-path: acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] Gene_or_gene_producttre2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt'interceding-token ngrams: the occlusiont,interceding-token ngrams: DNA binding domaintNe2: trigger-arg-path: Positive_activation >nsubj [lemma='this'] Generic_entityt#interceding-token ngrams: of p53 byt%interceding-token ngrams: promotes antHe2: trigger-arg-path: enhances:Positive_activation >nsubj Generic_entitytTe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='this'] Generic_entityt*interceding-token ngrams: PCAF promotes antwe1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] Gene_or_gene_productt interceding-token ngrams: p53 byt(interceding-token ngrams: the C-terminalt2interceding-token ngrams: preventing the occlusiont!interceding-token ngrams: the DNAtoe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] Gene_or_gene_productt+interceding-token ngrams: p53 by preventingtye1: trigger-arg-path: acetylation:Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] Gene_or_gene_productt\e1: trigger-arg-path: acetylation:Positive_regulation >prep_of >prep_by Gene_or_gene_producttme1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] Gene_or_gene_productt%interceding-token ngrams: and CBP andtse2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='this'] controller:Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=acetylation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controller:Gene_or_gene_producttNe2: trigger-arg-path: enhances >nsubj [lemma='this'] controller:Generic_entityt!interceding-token ngrams: an opent.interceding-token ngrams: open conformation oftinterceding-token ngrams: opentSe1: trigger-arg-path: acetylation >prep_of >prep_by controller:Gene_or_gene_producttie2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt+interceding-token ngrams: binding domain byt_e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='this'] controller:Generic_entityt+interceding-token ngrams: by preventing thethe2: trigger-arg-path: enhances:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt.interceding-token ngrams: an open conformationtbe2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='this'] controller:Generic_entitytWe2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='this'] Generic_entityt-interceding-token ngrams: the C-terminal tailt'interceding-token ngrams: PCAF promotest(interceding-token ngrams: binding domaintEe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj Generic_entitytce1: trigger-arg-path: Positive_regulation >prep_of [lemma='p53'] >prep_by [lemma='p300'] controllert?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='activity'] >nn [lemma='p53'] controlledt)interceding-token ngrams: C-terminal tailtSe2: trigger-arg-path: enhances:Positive_activation >nsubj [lemma='this'] controllert'interceding-token ngrams: domain by thet*interceding-token ngrams: promotes an opent4e2: ents2Label-mention-ngram: SHARED enhances SHAREDtTe2: trigger-arg-path: enhances >dobj [lemma='activity'] >nn [lemma='p53'] controlledt$interceding-token ngrams: of the DNAtGe1: trigger-arg-path: Binding >dobj [lemma='vdac'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk2'] theme:Gene_or_gene_productt>e1: trigger-arg-path: binds:Binding >dobj [lemma='vdac'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='hk2'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: betatee2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controller:Familyt%e2: args2Role-mention-ngram: 3 beta (t0e2: args2Role-mention-ngram: CONTROLLER kinase 3tke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='glycogen'] Familyt8e1: trigger-arg-path: Binding >dobj [lemma='vdac'] themet)e2: args2Role-mention-ngram: ( GSK3beta )t+e2: ents2Label-mention-ngram: kinase 3 betat-e2: ents2Label-mention-ngram: FAMILY kinase 3tce2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controllertVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk2'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn controller:Familyt(e2: args2Role-mention-ngram: Akt kinasest/e1: ents2Label-mention-ngram: only binds SHAREDt*e2: args2Role-mention-ngram: target of Aktt(e1: ents2Label-mention-ngram: only bindst*e2: ents2Label-mention-ngram: GSK3beta ) ,t+e2: ents2Label-mention-ngram: FAMILY kinaset8e1: trigger-arg-path: Binding >nsubj [lemma='hk2'] themet&e2: ents2Label-mention-ngram: 3 beta (t*e2: args2Role-mention-ngram: Akt kinases ,toe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controllert-e1: args2Role-mention-ngram: THEME only bindstje2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controller:Familyt*e2: ents2Label-mention-ngram: major targett>e1: trigger-arg-path: binds:Binding >nsubj [lemma='hk2'] themet[e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn Familyt$e2: ents2Label-mention-ngram: beta (tGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='vdac'] themet+e2: args2Role-mention-ngram: a major targett'e1: args2Role-mention-ngram: only bindst/interceding-token ngrams: after phosphorylationtKe1: trigger-arg-path: binds >nsubj [lemma='hk2'] theme:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controller:Familyt,e2: ents2Label-mention-ngram: a major targett2interceding-token ngrams: after phosphorylation byt6e2: ents2Label-mention-ngram: kinases , phosphorylatestEe1: trigger-arg-path: binds >nsubj [lemma='hk2'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: target of Aktt(e2: ents2Label-mention-ngram: ( GSK3betatOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='vdac'] themet'e2: args2Role-mention-ngram: ( GSK3betat'e2: ents2Label-mention-ngram: kinases ,tGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk2'] themet_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] Familytfe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj >nn controller:FamilytJe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn Familyt+e2: ents2Label-mention-ngram: Akt kinases ,t$e2: args2Role-mention-ngram: kinasest-e2: ents2Label-mention-ngram: beta ( GSK3betat\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='vdac'] theme:Gene_or_gene_producttAe2: trigger-arg-path: phosphorylates >nsubj >nn controller:Familyt$e2: ents2Label-mention-ngram: 3 betatOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk2'] themetye2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controller:FamilytSe1: trigger-arg-path: binds:Binding >dobj [lemma='vdac'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: major targettVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='vdac'] Gene_or_gene_productt!e2: args2Role-mention-ngram: betat#e2: args2Role-mention-ngram: beta (t^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk2'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: of Aktt%e2: args2Role-mention-ngram: kinase 3t)e2: args2Role-mention-ngram: GSK3beta ) ,tde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='vdac'] theme:Gene_or_gene_producttnsubj >nn Familyt6e1: trigger-arg-path: binds >dobj [lemma='vdac'] themetne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] Familyt&e2: args2Role-mention-ngram: kinases ,t-e1: args2Role-mention-ngram: only binds THEMEt*e2: ents2Label-mention-ngram: ( GSK3beta )te2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] Familyt%e2: args2Role-mention-ngram: GSK3betatMe1: trigger-arg-path: binds:Binding >nsubj [lemma='hk2'] Gene_or_gene_productt#e2: args2Role-mention-ngram: 3 betatUe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj >nn controller:Familyt6e1: trigger-arg-path: binds >nsubj [lemma='hk2'] themet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controller:Familyt"interceding-token ngrams: by Akt .t-e2: ents2Label-mention-ngram: major target oftEe1: trigger-arg-path: binds >dobj [lemma='vdac'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: of Akt kinasest+e2: args2Role-mention-ngram: of Akt kinasest^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='vdac'] Gene_or_gene_producttinterceding-token ngrams: Akt .t^e2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controllert&e2: ents2Label-mention-ngram: kinase 3tZe2: trigger-arg-path: phosphorylates >nsubj [lemma='kinase'] >nn [lemma='glycogen'] Familyt!CSSPATH: ROOT >parataxis ++ ROOT tMe1: trigger-arg-path: Binding >dobj [lemma='vdac'] theme:Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='hk2'] Gene_or_gene_productt0interceding-token ngrams: phosphorylation by Aktt#e2: args2Role-mention-ngram: of AkttMe1: trigger-arg-path: binds:Binding >dobj [lemma='vdac'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk2'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: GSK3beta )t7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT onlyt1e2: args2Role-mention-ngram: kinases , CONTROLLEDt'e1: args2Role-mention-ngram: THEME onlytGe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj >nn Familyt&e2: ents2Label-mention-ngram: GSK3betat,e2: args2Role-mention-ngram: major target oft5e2: ents2Label-mention-ngram: , phosphorylates SHAREDtKe1: trigger-arg-path: binds >dobj [lemma='vdac'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: GSK3beta )t)e2: ents2Label-mention-ngram: Akt kinasestre2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='kinase'] >nn [lemma='glycogen'] controllertSe1: trigger-arg-path: binds:Binding >nsubj [lemma='hk2'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: kinase 3 betatre1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlled:FamilytRe1: trigger-arg-path: elicits >nsubj [lemma='Lycopene'] controller:Simple_chemicalt{e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt-interceding-token ngrams: reductase ( HMG-CoAtIe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn Simple_chemicalt1e1: ents2Label-mention-ngram: inactivating SHAREDt+interceding-token ngrams: inhibition of thet)e1: args2Role-mention-ngram: inactivatingtwe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj [lemma='Lycopene'] controller:Simple_chemicaltHe1: trigger-arg-path: elicits:Positive_activation >nsubj Simple_chemicaltTe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt4e2: ents2Label-mention-ngram: treatment also reducest%interceding-token ngrams: reductase (t.interceding-token ngrams: decreased expressiontLe1: trigger-arg-path: elicits:Positive_activation >prepc_by >dobj controlledt/interceding-token ngrams: pathway and decreasedt?e1: trigger-arg-path: elicits >nsubj controller:Simple_chemicalt)e2: args2Role-mention-ngram: also reducestSe1: trigger-arg-path: elicits:Positive_activation >prepc_by >dobj controlled:FamilytVe1: trigger-arg-path: elicits:Positive_activation >nsubj [lemma='Lycopene'] controllertke2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllertXe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn controllert5e2: ents2Label-mention-ngram: farnesylation of SHAREDt3e2: args2Role-mention-ngram: reduces the CONTROLLEDt-e1: args2Role-mention-ngram: these changes byt2interceding-token ngrams: and decreased expressiontXe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='Lycopene'] Simple_chemicalte2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert'e1: args2Role-mention-ngram: changes byt4e1: trigger-arg-path: elicits >nsubj Simple_chemicalt#interceding-token ngrams: ( HMG-CoAtDe2: trigger-arg-path: Negative_regulation >nsubj >nn Simple_chemicalt(e1: ents2Label-mention-ngram: changes byt"interceding-token ngrams: coenzymet$interceding-token ngrams: coenzyme At?interceding-token ngrams: 3-hydroxy-3-methylglutaryl coenzyme At%interceding-token ngrams: A reductasetZe1: trigger-arg-path: elicits >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlledt+e1: ents2Label-mention-ngram: these changest@e1: trigger-arg-path: Positive_activation >prepc_by >dobj Familyt*e1: args2Role-mention-ngram: elicits thesetDe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn controllertue1: trigger-arg-path: elicits:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlled:Familyt(interceding-token ngrams: the mevalonatetke1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlledt1interceding-token ngrams: decreased expression oft,e1: args2Role-mention-ngram: by inactivatingt%interceding-token ngrams: ( HMG-CoA )t4interceding-token ngrams: 3-hydroxy-3-methylglutaryltDe1: trigger-arg-path: Positive_activation >prepc_by >dobj controlledtne2: trigger-arg-path: reduces:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert@interceding-token ngrams: of 3-hydroxy-3-methylglutaryl coenzymet4e1: args2Role-mention-ngram: changes by inactivatingt.e2: ents2Label-mention-ngram: farnesylation ofte2: trigger: reducest$e2: args2Role-mention-ngram: reducestSe1: trigger-arg-path: elicits:Positive_activation >nsubj controller:Simple_chemicalt.e2: ents2Label-mention-ngram: also reduces thetYe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by >dobj Familyt6e2: args2Role-mention-ngram: CONTROLLER treatment alsot#interceding-token ngrams: HMG-CoA )tfe1: trigger-arg-path: Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalthe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn controller:Simple_chemicaltEe1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by >dobj Familyt4e1: ents2Label-mention-ngram: by inactivating SHAREDt!interceding-token ngrams: HMG-CoAtBe1: trigger-arg-path: elicits >nsubj [lemma='Lycopene'] controllertVe1: trigger-arg-path: elicits >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] Familytne1: trigger-arg-path: elicits:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlledtde1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj controller:Simple_chemicalt+interceding-token ngrams: of the mevalonatetWe2: trigger-arg-path: reduces:Negative_regulation >nsubj >nn controller:Simple_chemicalt]e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by >dobj controlledt)e2: ents2Label-mention-ngram: reduces thet%interceding-token ngrams: pathway andt,interceding-token ngrams: via the inhibitiont*e1: ents2Label-mention-ngram: inactivatingtde1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by >dobj controlled:Familytme1: trigger-arg-path: Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlled:Familytve2: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicalt-e2: args2Role-mention-ngram: also reduces thetLe2: trigger-arg-path: reduces:Negative_regulation >nsubj >nn Simple_chemicalt0interceding-token ngrams: the mevalonate pathwaytje2: trigger-arg-path: reduces >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicaltje1: trigger-arg-path: elicits:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] Familyt@e1: trigger-arg-path: Positive_activation >nsubj Simple_chemicaltZe2: trigger-arg-path: reduces >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert%interceding-token ngrams: HMG-CoA ) .tBinterceding-token ngrams: expression of 3-hydroxy-3-methylglutaryltPe1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by >dobj controlled:Familyt3e2: args2Role-mention-ngram: treatment also reducest0interceding-token ngrams: mevalonate pathway andt7e2: ents2Label-mention-ngram: reduces the farnesylationt$e1: args2Role-mention-ngram: changest,e1: ents2Label-mention-ngram: SHARED elicitstSe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='Lycopene'] controllertCe1: trigger-arg-path: elicits:Positive_activation >nsubj controllert-e1: ents2Label-mention-ngram: by inactivatingte1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlledtbe1: trigger-arg-path: Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] Familyt%e1: ents2Label-mention-ngram: changestse2: trigger-arg-path: reduces:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicaltge1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj [lemma='Lycopene'] controllertNe1: trigger-arg-path: Positive_activation >nsubj [lemma='Lycopene'] controllertCe2: trigger-arg-path: reduces >nsubj >nn controller:Simple_chemicaltle1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj [lemma='Lycopene'] Simple_chemicaltYe1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >nsubj Simple_chemicalt7interceding-token ngrams: of 3-hydroxy-3-methylglutarylt4e1: trigger-arg-path: elicits >prepc_by >dobj Familyt'interceding-token ngrams: A reductase (t*e1: args2Role-mention-ngram: these changestke2: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt2e2: ents2Label-mention-ngram: the farnesylation oft[e1: trigger-arg-path: elicits:Positive_activation >nsubj [lemma='Lycopene'] Simple_chemicaltOe2: trigger-arg-path: Negative_regulation >nsubj >nn controller:Simple_chemicalt/e1: args2Role-mention-ngram: CONTROLLER elicitstPe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj controller:Simple_chemicalt+e2: args2Role-mention-ngram: treatment alsotHe1: trigger-arg-path: elicits:Positive_activation >prepc_by >dobj Familyt(e2: args2Role-mention-ngram: reduces thetfe1: trigger-arg-path: elicits:Positive_activation >nsubj [lemma='Lycopene'] controller:Simple_chemicalt3e2: ents2Label-mention-ngram: SHARED treatment alsot,e2: ents2Label-mention-ngram: treatment alsot/e2: ents2Label-mention-ngram: the farnesylationtEe1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj Simple_chemicalt7e1: args2Role-mention-ngram: by inactivating CONTROLLEDt2e1: args2Role-mention-ngram: elicits these changest?interceding-tokens-full-span: via the inhibition of the mevalonate pathway and decreased expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase ( HMG-CoA ) .t8e1: trigger-arg-path: elicits >prepc_by >dobj controlledtce1: trigger-arg-path: lemmatizedTrigger=elicit >nsubj [lemma='Lycopene'] controller:Simple_chemicaltpe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt1e2: args2Role-mention-ngram: CONTROLLER treatmentt+e1: ents2Label-mention-ngram: elicits theset~e2: trigger-arg-path: reduces:Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controller:Simple_chemicaltIe1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by >dobj controlledt3e2: trigger-arg-path: reduces >nsubj >nn controllert5e1: ents2Label-mention-ngram: changes by inactivatingt3e1: ents2Label-mention-ngram: elicits these changest,interceding-token ngrams: mevalonate pathwayt#interceding-token ngrams: reductasetGe2: trigger-arg-path: reduces:Negative_regulation >nsubj >nn controllert.interceding-token ngrams: coenzyme A reductaset^e1: trigger-arg-path: Positive_activation >nsubj [lemma='Lycopene'] controller:Simple_chemicalt?e1: trigger-arg-path: elicits >prepc_by >dobj controlled:Familyt=interceding-token ngrams: 3-hydroxy-3-methylglutaryl coenzymet_e2: trigger-arg-path: reduces >nsubj [lemma='treatment'] >nn [lemma='lycopene'] Simple_chemicalt8e2: trigger-arg-path: reduces >nsubj >nn Simple_chemicalt*e2: ents2Label-mention-ngram: also reducest$interceding-token ngrams: mevalonatet.e1: ents2Label-mention-ngram: these changes byt2e1: ents2Label-mention-ngram: SHARED elicits theset4e1: args2Role-mention-ngram: inactivating CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlled:FamilytGe1: trigger-arg-path: elicits >nsubj [lemma='Lycopene'] Simple_chemicaltSe1: trigger-arg-path: Positive_activation >nsubj [lemma='Lycopene'] Simple_chemicaltKe1: trigger-arg-path: Positive_activation >prepc_by >dobj controlled:Familytfe2: trigger-arg-path: Negative_regulation >nsubj [lemma='treatment'] >nn [lemma='lycopene'] controllert%e2: ents2Label-mention-ngram: reducest5e1: args2Role-mention-ngram: CONTROLLER elicits theset]e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj >nn Simple_chemicaltKe1: trigger-arg-path: Positive_activation >nsubj controller:Simple_chemicaltae1: trigger-arg-path: elicits >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] controlled:Familyt{e1: trigger-arg-path: lemmatizedTrigger=elicit:Positive_activation >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] Familytge1: trigger-arg-path: lemmatizedTrigger=elicit >prepc_by [lemma='inactivate'] >dobj [lemma='ra'] FamilytTe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj >nn controller:Simple_chemicaltJe1: trigger-arg-path: Binding >nsubj [lemma='Raptor'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] themetVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] themet0e2: ents2Label-mention-ngram: directly interactstee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] Gene_or_gene_productt=e1: trigger-arg-path: interacts >nsubj [lemma='Raptor'] themetee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttEe1: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] themet;e2: trigger-arg-path: Binding >nsubj [lemma='Raptor'] themet5e2: ents2Label-mention-ngram: directly interacts withtCshortest-path: advmod [lemma='directly']t/e2: args2Role-mention-ngram: directly interactstRe2: trigger-arg-path: interacts >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: directly interacts witht;e1: trigger-arg-path: Binding >nsubj [lemma='Raptor'] themetVe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] themet=e2: trigger-arg-path: interacts >nsubj [lemma='Raptor'] themetRe2: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttLe2: trigger-arg-path: interacts >nsubj [lemma='Raptor'] Gene_or_gene_productt\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttTe2: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttEe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] themetce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] themet\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] Gene_or_gene_producttCe1: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] themetLe1: trigger-arg-path: interacts >nsubj [lemma='Raptor'] Gene_or_gene_producttZe2: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] themetee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] Gene_or_gene_producttRe1: trigger-arg-path: interacts >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttbe2: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttPe2: trigger-arg-path: Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] Gene_or_gene_producttZe2: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] Gene_or_gene_productt5e1: args2Role-mention-ngram: THEME directly interactstPe1: trigger-arg-path: Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttZe1: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_producttbe1: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: directly interactstEe2: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] themet7e2: ents2Label-mention-ngram: SHARED directly interactstNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] themetZe1: trigger-arg-path: interacts >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='Raptor'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_productt5e2: args2Role-mention-ngram: THEME directly interactst^e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] themetke1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttMe1: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] themetEe1: trigger-arg-path: interacts:Binding >nsubj [lemma='Raptor'] themetCe2: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] themetme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_productt4e2: args2Role-mention-ngram: directly interacts withtke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='Raptor'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: directly interactstRe1: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttXe2: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='hif-1alpha'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED directly interactstMe2: trigger-arg-path: interacts:Binding >prep_with [lemma='hif-1alpha'] themet5e1: ents2Label-mention-ngram: directly interacts withtXe1: trigger-arg-path: Binding >prep_with [lemma='hif-1alpha'] theme:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='Raptor'] themetLe2: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] Gene_or_gene_producttMe2: trigger-arg-path: binds >nsubj [lemma='IGF-1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttMe1: trigger-arg-path: binds >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] themetJe2: trigger-arg-path: binds >prep_to [lemma='igf-1r'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] Gene_or_gene_productt8e1: trigger-arg-path: binds >nsubj [lemma='IGF-1'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] Gene_or_gene_producttRe1: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] Gene_or_gene_producttXe1: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttXe2: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] Gene_or_gene_producttOe2: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binds >nsubj [lemma='IGF-1'] Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttJe1: trigger-arg-path: binds >prep_to [lemma='igf-1r'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] themet:e1: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] themetfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_productt;e2: trigger-arg-path: binds >prep_to [lemma='igf-1r'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] themet8e2: trigger-arg-path: binds >nsubj [lemma='IGF-1'] themetLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] themetce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] Gene_or_gene_producttGe2: trigger-arg-path: binds >nsubj [lemma='IGF-1'] Gene_or_gene_producttRe2: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] themet@e2: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] themet;e1: trigger-arg-path: binds >prep_to [lemma='igf-1r'] themetPe2: trigger-arg-path: binds >prep_to [lemma='igf-1r'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] themetie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] themetPe1: trigger-arg-path: binds >prep_to [lemma='igf-1r'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='IGF-1'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='igf-1r'] themet:e2: trigger-arg-path: Binding >nsubj [lemma='IGF-1'] themetCe2: trigger-arg-path: binds:Binding >prep_to [lemma='igf-1r'] themetRe2: trigger-arg-path: Binding >prep_to [lemma='igf-1r'] theme:Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >nsubj [lemma='IGF-1'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='IGF-1'] themetee2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tnfalpha'] Familyt@e1: trigger-arg-path: complex:Binding >nn [lemma='raptor'] themet@e2: trigger-arg-path: activated >nsubj [lemma='tnfalpha'] FamilytSe2: trigger-arg-path: lemmatizedTrigger=activate >ccomp >nsubj Gene_or_gene_productt_e2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='tnfalpha'] controller:Familyt/interceding-token ngrams: and Raptor suppressortpe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tnfalpha'] controller:Familyt.interceding-token ngrams: , thereby activatingt(interceding-token ngrams: activating thet6e1: trigger-arg-path: complex >nn [lemma='mtor'] themetOe1: trigger-arg-path: complex:Binding >nn [lemma='raptor'] Gene_or_gene_producttUe1: trigger-arg-path: complex:Binding >nn [lemma='raptor'] theme:Gene_or_gene_productt"interceding-token ngrams: kinase .tAe2: trigger-arg-path: activated:Positive_activation >nsubj FamilytKe2: trigger-arg-path: activated >nsubj [lemma='tnfalpha'] controller:FamilytMe2: trigger-arg-path: activated >ccomp >nsubj controlled:Gene_or_gene_producttae2: trigger-arg-path: activated:Positive_activation >ccomp >nsubj controlled:Gene_or_gene_producttEe1: trigger-arg-path: complex >nn [lemma='mtor'] Gene_or_gene_productt*CSSPATH: ROOT >nsubjpass >prep_of ++ ROOT t?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] Gene_or_gene_producttpe2: trigger-arg-path: Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] Gene_or_gene_producttfe2: trigger-arg-path: activated >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] Gene_or_gene_productt%interceding-token ngrams: mTOR kinasetie2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tnfalpha'] controllert8e2: trigger-arg-path: activated >ccomp >nsubj controlledtMe1: trigger-arg-path: complex:Binding >nn [lemma='mtor'] Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >nsubj [lemma='tnfalpha'] Familyt,interceding-token ngrams: thereby activatingt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=activate >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlled:Gene_or_gene_productt-e2: trigger-arg-path: activated >nsubj Familytze2: trigger-arg-path: activated:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] Gene_or_gene_producttXe2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='tnfalpha'] controllert?interceding-tokens-full-span: by IKKalpha was induced by Akt kinase , whereas IKKbeta repressed the tuberous sclerosis complex ( TSC ) , which is an mTOR and Raptor suppressor , thereby activating the mTOR kinase .tqe2: trigger-arg-path: activated >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlled:Gene_or_gene_producttWe2: trigger-arg-path: Positive_activation >ccomp >nsubj controlled:Gene_or_gene_producttSe1: trigger-arg-path: complex:Binding >nn [lemma='mtor'] theme:Gene_or_gene_producttGe1: trigger-arg-path: complex >nn [lemma='raptor'] Gene_or_gene_producttTe2: trigger-arg-path: activated:Positive_activation >nsubj [lemma='tnfalpha'] FamilytDe2: trigger-arg-path: activated >nsubj [lemma='tnfalpha'] controllert0interceding-token ngrams: thereby activating thetUe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tnfalpha'] controllert.e2: ents2Label-mention-ngram: FAMILY activatedtQe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tnfalpha'] Familyt8e1: trigger-arg-path: complex >nn [lemma='raptor'] themetCe2: ents2Label-mention-ngram: FAMILY activated GENE_OR_GENE_PRODUCTtpe2: trigger-arg-path: activated:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlledt\e2: trigger-arg-path: activated >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlledtLe2: trigger-arg-path: activated:Positive_activation >ccomp >nsubj controlledtVe2: trigger-arg-path: activated:Positive_activation >ccomp >nsubj Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=activate >ccomp >nsubj controlled:Gene_or_gene_productt8e2: trigger-arg-path: activated >nsubj controller:FamilytMe1: trigger-arg-path: complex >nn [lemma='raptor'] theme:Gene_or_gene_productt-interceding-token ngrams: activating the mTORt]e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp >nsubj controlledt\e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tnfalpha'] controller:Familyt.interceding-token ngrams: suppressor , therebytge2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp >nsubj Gene_or_gene_productt)interceding-token ngrams: the mTOR kinaset?e2: trigger-arg-path: activated:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlled:Gene_or_gene_productt>e1: trigger-arg-path: complex:Binding >nn [lemma='mtor'] themet+interceding-token ngrams: Raptor suppressortre2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp >nsubj controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlled:Gene_or_gene_producttBe2: trigger-arg-path: activated >ccomp >nsubj Gene_or_gene_producttccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlledt{e2: trigger-arg-path: Positive_activation >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: Positive_activation >ccomp >nsubj Gene_or_gene_producttKe1: trigger-arg-path: complex >nn [lemma='mtor'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Positive_activation >nsubj [lemma='tnfalpha'] controllertwe2: trigger-arg-path: lemmatizedTrigger=activate >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] Gene_or_gene_productt-interceding-token ngrams: Raptor suppressor ,tLe2: trigger-arg-path: activated:Positive_activation >nsubj controller:Familyt'interceding-token ngrams: mTOR kinase .tIe2: trigger-arg-path: lemmatizedTrigger=activate >ccomp >nsubj controlledtme2: trigger-arg-path: lemmatizedTrigger=activate >ccomp [lemma='trigger'] >nsubj [lemma='ikkbeta'] controlledtUe2: trigger-arg-path: Positive_activation >nsubj [lemma='tnfalpha'] controller:Familyt+e1: trigger-arg-path: induced >agent Familyt2e1: ents2Label-mention-ngram: SHARED restored downt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlled:Negative_regulationt)e1: args2Role-mention-ngram: by oncogenictHe1: trigger-arg-path: Positive_regulation >agent [lemma='ra'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='knockdown'] >prep_of [lemma='omus'] Negative_regulationtOe1: trigger-arg-path: Positive_regulation >agent [lemma='ra'] controller:FamilytPe1: trigger-arg-path: Positive_regulation nsubj >prep_of controlledtDe1: trigger-arg-path: induced nsubj >prep_of controlledtXe1: trigger-arg-path: induced nsubj >prep_of controlled:Negative_regulationtGe1: trigger-arg-path: lemmatizedTrigger=induce >agent controller:Familyt6e1: trigger-arg-path: induced >agent controller:FamilytDe1: trigger-arg-path: Positive_regulation >agent [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlledt-e1: ents2Label-mention-ngram: SHARED restoredt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlled:Negative_regulationt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlledtWe1: trigger-arg-path: induced:Positive_regulation >agent [lemma='ra'] controller:Familyt1e1: args2Role-mention-ngram: induced by oncogenict&e1: args2Role-mention-ngram: oncogenictMe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ra'] controllertae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='ra'] controllertie1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlled:Negative_regulationt}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlled:Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlled:Negative_regulationtLe1: trigger-arg-path: induced:Positive_regulation >agent [lemma='ra'] Familyt?e1: trigger-arg-path: induced nsubj [lemma='knockdown'] >prep_of [lemma='omus'] Negative_regulationtPe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent FamilytMe1: trigger-arg-path: induced nsubj >prep_of Negative_regulationt1e1: args2Role-mention-ngram: oncogenic CONTROLLERt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] Negative_regulationt[e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controller:Familyt7e1: trigger-arg-path: Positive_regulation >agent Familytae1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of Negative_regulationt4e1: args2Role-mention-ngram: by oncogenic CONTROLLERtagent [lemma='ra'] controllert?e1: trigger-arg-path: induced nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlledt8e1: trigger-arg-path: induced >agent [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlledt?e1: trigger-arg-path: induced nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlled:Negative_regulationtde1: trigger-arg-path: Positive_regulation nsubj >prep_of controlled:Negative_regulationt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='ra'] Familyt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlledtYe1: trigger-arg-path: Positive_regulation nsubj >prep_of Negative_regulationte1: CONTROLLED: 4t?e1: trigger-arg-path: Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] Negative_regulationt?e1: trigger-arg-path: induced:Positive_regulation >agent Familythe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='ra'] controller:Familytre1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of Negative_regulationt^e1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of Negative_regulationtPe1: trigger-arg-path: induced:Positive_regulation >agent [lemma='ra'] controllertUe1: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlledtTe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ra'] controller:Familytle1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlled:Negative_regulationtJe1: trigger-arg-path: induced:Positive_regulation >agent controller:Familytie1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlledtXe1: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlledtBe1: trigger-arg-path: Positive_regulation >agent controller:Familyt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] controlled:Negative_regulationt?e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='knockdown'] >prep_of [lemma='omus'] Negative_regulationt+CSSPATH: ROOT >dobj >vmod ++ ROOT >conj_andtCe1: trigger-arg-path: induced >agent [lemma='ra'] controller:Familytagent FamilytIe1: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='ra'] Familyt>e2: trigger-arg-path: interaction >prep_of [lemma='ra'] Familyt?interceding-tokens-full-span: , while little binding was observed between GST-Raf-RBD or GST alone . Addition of nucleotide ( either GDP or GTPgammaS ) to the binding reaction prior to incubation at 30degreesC inhibitedt-interceding-token ngrams: nucleotide ( eithert!interceding-token ngrams: alone .t%interceding-token ngrams: GST-Raf-RBDt1e2: trigger-arg-path: interaction >prep_of FamilytMe2: trigger-arg-path: interaction:Binding >prep_of theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] Gene_or_gene_productt*interceding-token ngrams: binding reactiont(interceding-token ngrams: , while littlet interceding-token ngrams: littlet3e2: ents2Label-mention-ngram: interaction of SHAREDt0interceding-token ngrams: binding reaction priort'interceding-token ngrams: of nucleotidet\e1: trigger-arg-path: bound:Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] Gene_or_gene_producttLe2: trigger-arg-path: interaction:Binding >prep_of [lemma='ra'] theme:Familyt*interceding-token ngrams: GDP or GTPgammaStXe2: trigger-arg-path: Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt#interceding-token ngrams: GTPgammaStse1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] theme:Gene_or_gene_productt%interceding-token ngrams: Addition oft\e2: trigger-arg-path: interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt'interceding-token ngrams: to incubationt=e2: trigger-arg-path: interaction >prep_of [lemma='ra'] themet$interceding-token ngrams: . AdditiontVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='GST-PI3KC2beta-RBD'] themet0interceding-token ngrams: between GST-Raf-RBD ort#interceding-token ngrams: GST alonet'interceding-token ngrams: . Addition oft?e2: trigger-arg-path: interaction >prep_of Gene_or_gene_productt*interceding-token ngrams: alone . AdditiontOe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ra'] themet\e1: trigger-arg-path: Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: directly boundtPe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ra'] FamilytUe2: trigger-arg-path: interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] themetje2: trigger-arg-path: interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttZe1: trigger-arg-path: bound >nsubj [lemma='GST-PI3KC2beta-RBD'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] themetde2: trigger-arg-path: interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt.interceding-token ngrams: while little bindingt'interceding-token ngrams: at 30degreesCtKe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of Familyt'interceding-token ngrams: incubation att:e1: ents2Label-mention-ngram: bound nucleotide-free SHAREDt;e1: args2Role-mention-ngram: directly bound nucleotide-freet^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ra'] theme:Familytne2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] themet.interceding-token ngrams: was observed betweent3e1: ents2Label-mention-ngram: SHARED directly boundtBe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of themetJe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of themet2e1: args2Role-mention-ngram: bound nucleotide-freetTe1: trigger-arg-path: bound >nsubj [lemma='GST-PI3KC2beta-RBD'] Gene_or_gene_productt8e1: args2Role-mention-ngram: bound nucleotide-free THEMEt%interceding-token ngrams: GST alone .t*interceding-token ngrams: observed betweent6interceding-token ngrams: observed between GST-Raf-RBDt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of theme:Gene_or_gene_productt$interceding-token ngrams: incubationt0interceding-token ngrams: Addition of nucleotidet(interceding-token ngrams: to the bindingt(interceding-token ngrams: GST-Raf-RBD ortCe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of Familyt3e1: ents2Label-mention-ngram: bound nucleotide-freetinterceding-token ngrams: alonet)interceding-token ngrams: of nucleotide (t1interceding-token ngrams: at 30degreesC inhibitedtDe2: trigger-arg-path: interaction >prep_of [lemma='ra'] theme:Familytbe2: trigger-arg-path: interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt*interceding-token ngrams: to incubation att8e2: trigger-arg-path: interaction:Binding >prep_of themetGe2: trigger-arg-path: interaction:Binding >prep_of Gene_or_gene_productt(interceding-token ngrams: GTPgammaS ) tot(interceding-token ngrams: little bindingt&interceding-token ngrams: while littlet0e2: trigger-arg-path: interaction >prep_of themet1e2: args2Role-mention-ngram: interaction of THEMEtnsubj [lemma='GST-PI3KC2beta-RBD'] themet"interceding-token ngrams: reactiont+e1: args2Role-mention-ngram: directly boundt^e2: trigger-arg-path: Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt9e2: trigger-arg-path: interaction:Binding >prep_of Familyt"interceding-token ngrams: ) to thetve2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt$interceding-token ngrams: either GDPt(interceding-token ngrams: or GTPgammaS )t&interceding-token ngrams: nucleotide (tge2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] themet"interceding-token ngrams: Additiont"interceding-token ngrams: ( eithertee1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='GST-PI3KC2beta-RBD'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of theme:FamilytQe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of theme:FamilytXe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ra'] Familyt-interceding-token ngrams: prior to incubationt interceding-token ngrams: or GSTtEe2: trigger-arg-path: interaction >prep_of theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of theme:Gene_or_gene_productt&interceding-token ngrams: ( either GDPt1e1: args2Role-mention-ngram: THEME directly boundtGe1: trigger-arg-path: Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] themetYe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of Gene_or_gene_productt$interceding-token ngrams: 30degreesCt|e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt&interceding-token ngrams: or GST alonet7e2: trigger-arg-path: interaction >prep_of theme:FamilytEe1: trigger-arg-path: bound >nsubj [lemma='GST-PI3KC2beta-RBD'] themetke1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='GST-PI3KC2beta-RBD'] theme:Gene_or_gene_productt?e2: trigger-arg-path: interaction:Binding >prep_of theme:FamilytQe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of Gene_or_gene_productt.interceding-token ngrams: the binding reactiontVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ra'] theme:Familyt interceding-token ngrams: GDP ortMe1: trigger-arg-path: bound:Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] themet2interceding-token ngrams: incubation at 30degreesCt,interceding-token ngrams: GST-Raf-RBD or GSTt%interceding-token ngrams: GTPgammaS )t+interceding-token ngrams: reaction prior totFe2: trigger-arg-path: interaction:Binding >prep_of [lemma='ra'] Familyt&interceding-token ngrams: or GTPgammaStbe1: trigger-arg-path: bound:Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] theme:Gene_or_gene_productt'interceding-token ngrams: either GDP ort,interceding-token ngrams: little binding wastWe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ra'] themet.interceding-token ngrams: 30degreesC inhibitedt.interceding-token ngrams: binding was observedt%interceding-token ngrams: binding wast-interceding-token ngrams: between GST-Raf-RBDtte2: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttVe1: trigger-arg-path: Binding >nsubj [lemma='GST-PI3KC2beta-RBD'] Gene_or_gene_producttEe2: trigger-arg-path: interaction:Binding >prep_of [lemma='ra'] themet(interceding-token ngrams: reaction priortMe2: trigger-arg-path: interaction >prep_of [lemma='gst-pi3kc2beta-rbd'] themetinterceding-token ngrams: , Int4interceding-token ngrams: kinases in erythroleukemiat+e2: args2Role-mention-ngram: , indicating atinterceding-token ngrams: ERK ,t-e2: args2Role-mention-ngram: critical role oftYe2: trigger-arg-path: lemmatizedTrigger=induce >xcomp >dobj >prep_of Gene_or_gene_productt-e2: ents2Label-mention-ngram: a critical rolet$interceding-token ngrams: , In thesetXe1: trigger-arg-path: activation:Positive_regulation >nn controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >xcomp >dobj >prep_of controlled:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp >dobj >prep_of controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: , indicating atXe1: trigger-arg-path: activation:Positive_regulation >nn [lemma='telomerase'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlledt'e2: args2Role-mention-ngram: indicatingt?e2: trigger-arg-path: induced:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlled:Gene_or_gene_productt&e2: ents2Label-mention-ngram: criticalt+e2: ents2Label-mention-ngram: critical rolet!e2: args2Role-mention-ngram: mRNAtwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='erythropoietin'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn Gene_or_gene_productt/interceding-token ngrams: erythroleukemia cellst)e2: args2Role-mention-ngram: upregulationt-e2: args2Role-mention-ngram: STAT5-c-Myc axist,e2: args2Role-mention-ngram: a critical rolet,e1: args2Role-mention-ngram: and concomitantt\e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='erythropoietin'] controllert$e2: args2Role-mention-ngram: mRNA ist(e2: ents2Label-mention-ngram: indicatingtxcomp >dobj >prep_of controlledt3e1: args2Role-mention-ngram: concomitant CONTROLLEDt1interceding-token ngrams: erythroleukemia cells .t2interceding-token ngrams: in erythroleukemia cellst"e2: ents2Label-mention-ngram: axist,e2: args2Role-mention-ngram: upregulation oft"e2: ents2Label-mention-ngram: roletMe1: trigger-arg-path: activation:Positive_regulation >nn Gene_or_gene_productt"interceding-token ngrams: In theset-e2: args2Role-mention-ngram: mRNA is mediatedt1e2: args2Role-mention-ngram: the STAT5-c-Myc axist?e2: trigger-arg-path: induced:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] Gene_or_gene_productt)interceding-token ngrams: erythroleukemiatinterceding-token ngrams: , ERKt=e1: ents2Label-mention-ngram: and concomitant phosphorylationtYe1: trigger-arg-path: activation >nn [lemma='telomerase'] controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: indicating a criticalt interceding-token ngrams: . , IntTe2: trigger-arg-path: Positive_activation >nsubj [lemma='erythropoietin'] controllert,interceding-token ngrams: in erythroleukemiat2e2: ents2Label-mention-ngram: the STAT5-c-Myc axist)e2: ents2Label-mention-ngram: STAT5-c-Myctce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erythropoietin'] Gene_or_gene_producttfe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='erythropoietin'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp >dobj >prep_of controlledtme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp >dobj >prep_of Gene_or_gene_productt$e2: ents2Label-mention-ngram: axis ,tAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activation andt'e2: args2Role-mention-ngram: telomerasetRe2: trigger-arg-path: induced >nsubj [lemma='erythropoietin'] Gene_or_gene_producttRe2: trigger-arg-path: induced:Positive_activation >xcomp >dobj >prep_of controlledt/e2: args2Role-mention-ngram: role of CONTROLLEDt>e2: trigger-arg-path: induced >xcomp >dobj >prep_of controlledt*e2: ents2Label-mention-ngram: indicating at(interceding-token ngrams: Akt kinases int*e2: args2Role-mention-ngram: of telomeraset/e2: args2Role-mention-ngram: telomerase mRNA istWe1: trigger-arg-path: Positive_regulation >nn [lemma='telomerase'] Gene_or_gene_producttGe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced upregulationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erythropoietin'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: , indicatingtme1: trigger-arg-path: activation:Positive_regulation >nn [lemma='telomerase'] controller:Gene_or_gene_productt!interceding-token ngrams: , ERK ,tNe1: trigger-arg-path: activation >nn [lemma='telomerase'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] Gene_or_gene_producttHe2: trigger-arg-path: induced >nsubj [lemma='erythropoietin'] controllert-e1: ents2Label-mention-ngram: and concomitantt4e2: args2Role-mention-ngram: induced upregulation oft+e1: args2Role-mention-ngram: activation andt%e2: ents2Label-mention-ngram: role oftMe1: trigger-arg-path: Positive_regulation >nn [lemma='telomerase'] controllert!interceding-token ngrams: and Aktt(e2: ents2Label-mention-ngram: telomeraset'interceding-token ngrams: these cells ,t%interceding-token ngrams: these cellst-e2: ents2Label-mention-ngram: the STAT5-c-Myct?e2: trigger-arg-path: Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='telomerase'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='telomerase'] controllertCe1: trigger-arg-path: activation:Positive_regulation >nn controllertYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='erythropoietin'] controllert6e1: args2Role-mention-ngram: CONTROLLER activation andt0e2: ents2Label-mention-ngram: telomerase mRNA istginterceding-tokens-full-span: , ERK , and Akt kinases in erythroleukemia cells . , In these cells , thet(e2: args2Role-mention-ngram: STAT5-c-Myct)interceding-token ngrams: and Akt kinasestqe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='erythropoietin'] controller:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='telomerase'] controller:Gene_or_gene_productt#interceding-token ngrams: ERK , andt"e2: ents2Label-mention-ngram: mRNAt^e2: trigger-arg-path: Positive_activation >nsubj [lemma='erythropoietin'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlledt3e2: ents2Label-mention-ngram: indicating a criticalt1e2: args2Role-mention-ngram: induced upregulationt#interceding-token ngrams: , and Akttje1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn controller:Gene_or_gene_productt(interceding-token ngrams: In these cellst#e2: args2Role-mention-ngram: axis ,tje1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='telomerase'] controllert,e2: args2Role-mention-ngram: the STAT5-c-Myct+e2: ents2Label-mention-ngram: of telomeraset)e2: args2Role-mention-ngram: indicating at?e2: trigger-arg-path: lemmatizedTrigger=induce >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlled:Gene_or_gene_productt7e1: args2Role-mention-ngram: activation and concomitantt-e2: ents2Label-mention-ngram: telomerase mRNAt0e2: ents2Label-mention-ngram: STAT5-c-Myc axis ,t7e1: args2Role-mention-ngram: and concomitant CONTROLLEDt/e2: args2Role-mention-ngram: of telomerase mRNAt)e2: args2Role-mention-ngram: , indicatingt8e2: ents2Label-mention-ngram: upregulation of telomeraset\e2: trigger-arg-path: induced:Positive_activation >xcomp >dobj >prep_of Gene_or_gene_productt!e2: args2Role-mention-ngram: axist?e2: trigger-arg-path: induced:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlledt|e2: trigger-arg-path: Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlledtUe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlled:Gene_or_gene_producttbe1: trigger-arg-path: Positive_regulation >nn [lemma='telomerase'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: STAT5-c-Myc axis ,t,e2: ents2Label-mention-ngram: role of SHAREDt5e2: ents2Label-mention-ngram: induced upregulation oft7e2: args2Role-mention-ngram: upregulation of telomeraset%interceding-token ngrams: cells , thetTe2: trigger-arg-path: Positive_activation >xcomp >dobj >prep_of Gene_or_gene_productt,e2: args2Role-mention-ngram: telomerase mRNAt#interceding-token ngrams: cells . ,t%e2: ents2Label-mention-ngram: mRNA ist(e2: ents2Label-mention-ngram: a criticalt.e2: args2Role-mention-ngram: axis , indicatingt0e2: ents2Label-mention-ngram: of telomerase mRNAt!e2: args2Role-mention-ngram: rolet2e2: ents2Label-mention-ngram: induced upregulationtbe1: trigger-arg-path: activation:Positive_regulation >nn [lemma='telomerase'] Gene_or_gene_producttDe1: trigger-arg-path: activation >nn [lemma='telomerase'] controllert$e2: args2Role-mention-ngram: role oftnsubj [lemma='erythropoietin'] controllert.e2: ents2Label-mention-ngram: mRNA is mediatedt/e2: args2Role-mention-ngram: by the STAT5-c-Myct'e2: args2Role-mention-ngram: a criticalt?e2: trigger-arg-path: Positive_activation >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlled:Gene_or_gene_producttpe2: trigger-arg-path: induced >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlledtie2: trigger-arg-path: Positive_activation >nsubj [lemma='erythropoietin'] controller:Gene_or_gene_productt$interceding-token ngrams: kinases int*e2: args2Role-mention-ngram: critical rolete1: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='telomerase'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: upregulation oft%e2: args2Role-mention-ngram: criticalt.e2: ents2Label-mention-ngram: STAT5-c-Myc axistge2: trigger-arg-path: induced:Positive_activation >xcomp >dobj >prep_of controlled:Gene_or_gene_productt?e2: trigger-arg-path: induced >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] controlled:Gene_or_gene_producttJe2: trigger-arg-path: Positive_activation >xcomp >dobj >prep_of controlledt8e1: ents2Label-mention-ngram: activation and concomitantt]e2: trigger-arg-path: induced >nsubj [lemma='erythropoietin'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='erythropoietin'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: by the STAT5-c-Myctde2: trigger-arg-path: lemmatizedTrigger=induce >xcomp >dobj >prep_of controlled:Gene_or_gene_producttHe2: trigger-arg-path: induced >xcomp >dobj >prep_of Gene_or_gene_productt%interceding-token ngrams: Akt kinasestSe2: trigger-arg-path: induced >xcomp >dobj >prep_of controlled:Gene_or_gene_productt/e2: ents2Label-mention-ngram: axis , indicatingt`e1: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='telomerase'] Gene_or_gene_producttze2: trigger-arg-path: induced >xcomp [lemma='indicate'] >dobj [lemma='role'] >prep_of [lemma='stat5'] Gene_or_gene_producttee1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] Gene_or_gene_producttFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] Sitetke1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] Gene_or_gene_producttBe1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] site:Sitet;interceding-tokens-full-span: in vitro . In contrast to thet!interceding-token ngrams: vitro .tte1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gef'] themetde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gef'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gef'] theme:Gene_or_gene_productt.CSSPATH: ROOT >ccomp ++ ROOT >prep_in >prep_tot=e1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] Sitet|e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='gef'] themet)interceding-token ngrams: contrast to thetie1: trigger-arg-path: binds >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] themet8e1: args2Role-mention-ngram: binds nucleotide-free THEMEt9e1: ents2Label-mention-ngram: RBD of GENE_OR_GENE_PRODUCTt:e1: trigger-arg-path: binds >nsubj [lemma='rbd'] site:Sitet:e1: ents2Label-mention-ngram: binds nucleotide-free SHAREDtDe2: trigger-arg-path: complex >nn [lemma='gef'] Gene_or_gene_producttHe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds nucleotide-freet?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] theme:Gene_or_gene_producttce1: trigger-arg-path: binds >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nn [lemma='gef'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='gef'] theme:Gene_or_gene_productt;e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT bindst5e1: trigger-arg-path: binds >nsubj [lemma='rbd'] sitet$interceding-token ngrams: vitro . Int5e2: trigger-arg-path: Binding >nn [lemma='gef'] themetGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gef'] themetDe2: trigger-arg-path: Binding >nn [lemma='gef'] Gene_or_gene_producttTe1: trigger-arg-path: binds >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] themetnsubj [lemma='rbd'] site:SitetVe1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] themet5e2: trigger-arg-path: complex >nn [lemma='gef'] themetRe2: trigger-arg-path: complex:Binding >nn [lemma='gef'] theme:Gene_or_gene_productt$interceding-token ngrams: in vitro .t\e1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] themetme1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] themet7e1: trigger-arg-path: Binding >nsubj [lemma='rbd'] sitetSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] site:Sitetze1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='gef'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: binds nucleotide-freetqe1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] sitet5e1: trigger-arg-path: binds >nsubj [lemma='rbd'] Sitet7e1: trigger-arg-path: Binding >nsubj [lemma='rbd'] SitetVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gef'] Gene_or_gene_productt8e1: args2Role-mention-ngram: THEME binds nucleotide-freetKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] site:Sitet2e1: args2Role-mention-ngram: binds nucleotide-freetke1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='pi3kc2beta'] theme:Gene_or_gene_productt=e1: trigger-arg-path: binds:Binding >nsubj [lemma='rbd'] sitetFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] sitet$e1: ents2Label-mention-ngram: RBD oft^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gef'] Gene_or_gene_productt(interceding-token ngrams: In contrast totNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] Sitet3e1: args2Role-mention-ngram: expression rescued thetHe1: trigger-arg-path: restored:Positive_regulation >nsubj >nn controllert}e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controllertKe2: trigger-arg-path: Positive_activation >nsubj [lemma='hipk2'] controllert7e1: ents2Label-mention-ngram: restored K382 acetylationt]e2: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='hipk2'] Gene_or_gene_productt)interceding-token ngrams: to adriamycin .tne1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: other kinasest0e1: args2Role-mention-ngram: knockdown cells andt)e1: ents2Label-mention-ngram: kinases ) ,t4e1: ents2Label-mention-ngram: expression rescued thet+e1: ents2Label-mention-ngram: restored K382t%e1: ents2Label-mention-ngram: rescuedt3interceding-token ngrams: apoptotic gene expressiont0e1: ents2Label-mention-ngram: phenotype of HIPK2t$e1: args2Role-mention-ngram: rescuedt.e1: ents2Label-mention-ngram: the phenotype oft*e1: ents2Label-mention-ngram: and restoredt"e1: ents2Label-mention-ngram: K382t&e1: args2Role-mention-ngram: phenotypet?interceding-tokens-full-span: dependent apoptotic gene expression and cell death in response to adriamycin . This suggests that whiletke2: trigger-arg-path: enhance >dobj [lemma='regulation'] >nn [lemma='p300'] controlled:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='regulation'] >nn [lemma='p300'] controlled:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='regulation'] >nn [lemma='p300'] controlledt)interceding-token ngrams: . This suggestst-e1: ents2Label-mention-ngram: knockdown cellst0e1: ents2Label-mention-ngram: cells and restoredt0e1: ents2Label-mention-ngram: expression rescuedt/e1: args2Role-mention-ngram: expression rescuedtXe1: trigger-arg-path: restored >nsubj [lemma='expression'] >nn [lemma='p300'] controllert/e1: ents2Label-mention-ngram: and restored K382tme1: trigger-arg-path: restored >nsubj [lemma='expression'] >nn [lemma='p300'] controller:Gene_or_gene_producttIe1: trigger-arg-path: restored >nsubj >nn controller:Gene_or_gene_productt-interceding-token ngrams: dependent apoptotict3e2: args2Role-mention-ngram: CONTROLLER can enhancet?e1: trigger-arg-path: restored:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: the phenotypet/e1: ents2Label-mention-ngram: phosphorylation (t~e1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='expression'] >nn [lemma='p300'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: can enhance SHAREDt(e2: args2Role-mention-ngram: can enhancet.e1: ents2Label-mention-ngram: by other kinasest+interceding-token ngrams: adriamycin . Thistxe1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: and restored CONTROLLEDt-interceding-token ngrams: expression and cellt/e1: args2Role-mention-ngram: of HIPK2 knockdownt!e1: ents2Label-mention-ngram: S46tQe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='hipk2'] controllertEe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >nn controllert*e1: ents2Label-mention-ngram: ( presumablytle1: trigger-arg-path: restored:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controllerthe2: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt'interceding-token ngrams: This suggeststRe1: trigger-arg-path: restored:Positive_regulation >nsubj >nn Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='expression'] >nn [lemma='p300'] Gene_or_gene_productt-e1: args2Role-mention-ngram: the phenotype oft0e1: ents2Label-mention-ngram: K382 acetylation ,tte2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] Gene_or_gene_producttUe2: trigger-arg-path: Positive_activation >nsubj [lemma='hipk2'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='expression'] >nn [lemma='p300'] controllert'e1: ents2Label-mention-ngram: phenotypetFe2: trigger-arg-path: enhance:Positive_activation >dobj >nn controlledt3e2: args2Role-mention-ngram: can enhance CONTROLLEDtje2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlledt)e1: args2Role-mention-ngram: phenotype oft)e1: ents2Label-mention-ngram: rescued thet0interceding-token ngrams: response to adriamycint7e1: ents2Label-mention-ngram: SHARED expression rescuedtme1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: of HIPK2 knockdownt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can enhancet,interceding-token ngrams: This suggests thatt+e1: ents2Label-mention-ngram: acetylation ,tOe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >nn Gene_or_gene_producttPe2: trigger-arg-path: enhance:Positive_activation >dobj >nn Gene_or_gene_productt3e1: ents2Label-mention-ngram: , S46 phosphorylationt]e1: trigger-arg-path: restored:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt-CSSPATH: ROOT >conj_and ++ ROOT >ccomp >advclt4e1: trigger-arg-path: restored >nsubj >nn controllert2e1: args2Role-mention-ngram: rescued the phenotypet>e1: trigger-arg-path: restored >nsubj >nn Gene_or_gene_producttTe2: trigger-arg-path: enhance >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt,e1: args2Role-mention-ngram: HIPK2 knockdowntze2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: enhance >nsubj [lemma='hipk2'] controllertce1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controllertVe2: trigger-arg-path: enhance >dobj [lemma='regulation'] >nn [lemma='p300'] controlledt2interceding-token ngrams: dependent apoptotic genet0e1: args2Role-mention-ngram: restored CONTROLLEDtGe2: trigger-arg-path: enhance >dobj >nn controlled:Gene_or_gene_producttdobj >nn Gene_or_gene_producttCe2: trigger-arg-path: enhance:Positive_activation >nsubj controllert-e1: ents2Label-mention-ngram: ( presumably byt-e1: ents2Label-mention-ngram: other kinases )tXe2: trigger-arg-path: enhance:Positive_activation >nsubj controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: rescued the phenotypetoe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='hipk2'] Gene_or_gene_productt(e1: args2Role-mention-ngram: rescued thet,e1: args2Role-mention-ngram: knockdown cellstZe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj >nn controller:Gene_or_gene_productt`e2: trigger-arg-path: enhance >dobj [lemma='regulation'] >nn [lemma='p300'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: phenotype oft?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] Gene_or_gene_producttbe1: trigger-arg-path: restored >nsubj [lemma='expression'] >nn [lemma='p300'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlledt:e1: args2Role-mention-ngram: CONTROLLER expression rescuedt2e2: trigger-arg-path: enhance >dobj >nn controlledt+e1: ents2Label-mention-ngram: the phenotypet(e1: ents2Label-mention-ngram: presumablyt+e1: ents2Label-mention-ngram: presumably byte2: trigger-arg-path: enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: enhance SHAREDtYe1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj >nn controllert'interceding-token ngrams: to adriamycint[e2: trigger-arg-path: enhance:Positive_activation >dobj >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: K382 acetylationt$interceding-token ngrams: adriamycint&interceding-token ngrams: adriamycin .t)e1: args2Role-mention-ngram: and restoredt-interceding-token ngrams: gene expression andt?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] Gene_or_gene_producttMe2: trigger-arg-path: enhance:Positive_activation >nsubj Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=restore:Positive_regulation >nsubj >nn Gene_or_gene_producttwe2: trigger-arg-path: Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlled:Gene_or_gene_productt/e1: ents2Label-mention-ngram: acetylation , S46t+interceding-token ngrams: death in responset%e1: args2Role-mention-ngram: of HIPK2tSe2: trigger-arg-path: enhance:Positive_activation >nsubj [lemma='hipk2'] controllert-interceding-token ngrams: suggests that whilet&e1: ents2Label-mention-ngram: by othert`e2: trigger-arg-path: Positive_activation >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: kinases )tle2: trigger-arg-path: Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >nsubj [lemma='hipk2'] controllert1e1: ents2Label-mention-ngram: S46 phosphorylationt/e1: args2Role-mention-ngram: phenotype of HIPK2t%e1: ents2Label-mention-ngram: ) , andt#interceding-token ngrams: apoptotict2e1: args2Role-mention-ngram: HIPK2 knockdown cellst:e1: ents2Label-mention-ngram: phosphorylation ( presumablytIe2: trigger-arg-path: enhance >nsubj [lemma='hipk2'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: HIPK2 knockdownt&e1: ents2Label-mention-ngram: of HIPK2t?e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='hipk2'] Gene_or_gene_producttve1: trigger-arg-path: restored:Positive_regulation >nsubj [lemma='expression'] >nn [lemma='p300'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: S46 phosphorylation (tre2: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='regulation'] >nn [lemma='p300'] Gene_or_gene_productt(interceding-token ngrams: apoptotic genet/e1: args2Role-mention-ngram: cells and restoredt#e1: ents2Label-mention-ngram: , S46t3e1: ents2Label-mention-ngram: HIPK2 knockdown cellst1e1: ents2Label-mention-ngram: presumably by othert/e2: args2Role-mention-ngram: enhance CONTROLLEDt1e1: ents2Label-mention-ngram: knockdown cells andt|e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_activation >dobj [lemma='regulation'] >nn [lemma='p300'] controlledtfe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='hipk2'] controller:Gene_or_gene_productt?e2: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] themetLe2: trigger-arg-path: complex >nn [lemma='cdc25'] theme:Gene_or_gene_productt?shortest-path: prep [lemma='give'] >pobj [lemma='similarity'] >prep_of [lemma='value'] >prep_for [lemma='ra']tAshortest-path: prep >pobj >prep_of >prep_fortXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] theme:Gene_or_gene_producttqtrigger-to-trigger-path: e1:interaction:Binding prep >pobj >prep_of >prep_for e2:complex:Bindingt`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] Gene_or_gene_producttFe2: trigger-arg-path: complex >nn [lemma='cdc25'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] themetTe2: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttNe2: trigger-arg-path: complex:Binding >nn [lemma='cdc25'] Gene_or_gene_productt?trigger-to-trigger-path: e1:interaction:Binding prep [lemma='give'] >pobj [lemma='similarity'] >prep_of [lemma='value'] >prep_for [lemma='complex'] e2:complex:Bindingt7e2: trigger-arg-path: complex >nn [lemma='cdc25'] themetIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdc25'] themetfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdc25'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='par3'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] themetIe1: trigger-arg-path: binds:Binding >prep_with theme:Gene_or_gene_producttCe2: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] themetPe2: trigger-arg-path: binds >prep_with [lemma='par3'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: and co-localisest3e1: args2Role-mention-ngram: binds and co-localisest4e1: ents2Label-mention-ngram: binds and co-localisestRe1: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='par3'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] Gene_or_gene_producttPe1: trigger-arg-path: binds >prep_with [lemma='par3'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] theme:Gene_or_gene_productt,e1: trigger-arg-path: binds >prep_with themetJe2: trigger-arg-path: binds >prep_with [lemma='par3'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: co-localisest*e2: ents2Label-mention-ngram: co-localisest-e2: args2Role-mention-ngram: and co-localisest4e2: args2Role-mention-ngram: co-localises with THEMEtRe2: trigger-arg-path: Binding >prep_with [lemma='par3'] theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: co-localises with SHAREDt3e2: args2Role-mention-ngram: binds and co-localisest2e2: args2Role-mention-ngram: and co-localises witht/e2: ents2Label-mention-ngram: co-localises witht.e1: ents2Label-mention-ngram: and co-localisest.e1: args2Role-mention-ngram: co-localises withtJe1: trigger-arg-path: binds >prep_with [lemma='par3'] Gene_or_gene_productt4e1: trigger-arg-path: binds:Binding >prep_with themetCe1: trigger-arg-path: binds:Binding >prep_with Gene_or_gene_producttAe1: trigger-arg-path: binds >prep_with theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: co-localises with SHAREDt.e1: ents2Label-mention-ngram: SHARED binds andt2e1: args2Role-mention-ngram: and co-localises withtRe2: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] Gene_or_gene_producttXe2: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] Gene_or_gene_producttXe1: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] theme:Gene_or_gene_productt-e1: args2Role-mention-ngram: and co-localisestTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] themet3e1: ents2Label-mention-ngram: and co-localises withtRe1: trigger-arg-path: Binding >prep_with [lemma='par3'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] themet;e1: trigger-arg-path: binds >prep_with Gene_or_gene_productt;e2: trigger-arg-path: binds >prep_with [lemma='par3'] themetCe1: trigger-arg-path: binds:Binding >prep_with [lemma='par3'] themetae1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: co-localisestae2: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='par3'] theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: binds and co-localisestZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: co-localises witht4e1: args2Role-mention-ngram: co-localises with THEMEt3e2: ents2Label-mention-ngram: and co-localises withtTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with Gene_or_gene_productt.e2: args2Role-mention-ngram: co-localises witht;e1: trigger-arg-path: binds >prep_with [lemma='par3'] themetie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='par3'] theme:Gene_or_gene_productt=e2: trigger-arg-path: Binding >prep_with [lemma='par3'] themet)e1: args2Role-mention-ngram: co-localisest=e1: trigger-arg-path: Binding >prep_with [lemma='par3'] themet"interceding-token ngrams: ( mTORC1tue2: trigger-arg-path: phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: ERK phosphorylatest0e1: ents2Label-mention-ngram: inactivates SHAREDt$interceding-token ngrams: 1 ( mTORC1t?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controller:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controllert%interceding-token ngrams: complex 1 (t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] Gene_or_gene_productt&interceding-token ngrams: mTOR complext%interceding-token ngrams: of Rheb andt#interceding-token ngrams: complex 1t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controllertne2: trigger-arg-path: Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] Gene_or_gene_productt/e1: args2Role-mention-ngram: and ERK CONTROLLEDt4e1: ents2Label-mention-ngram: ERK phosphorylates andt+interceding-token ngrams: and activation oft$interceding-token ngrams: ( mTORC1 )t2interceding-token ngrams: releasing the inhibitiont4e1: ents2Label-mention-ngram: and inactivates SHAREDtje2: trigger-arg-path: phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] Gene_or_gene_productt,interceding-token ngrams: inhibition of Rhebt'interceding-token ngrams: releasing thet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: and ERK phosphorylatest|interceding-tokens-full-span: , releasing the inhibition of Rheb and activation of mTOR complex 1 ( mTORC1 ) . In contrast ,t,interceding-token ngrams: activation of mTORt-e1: ents2Label-mention-ngram: and inactivatest?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controller:Gene_or_gene_producttye2: trigger-arg-path: Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controller:Gene_or_gene_productt!interceding-token ngrams: of Rhebt(interceding-token ngrams: and activationt$interceding-token ngrams: mTORC1 ) .tprep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controllertte2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controllert`e2: trigger-arg-path: phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] controllert"interceding-token ngrams: Rheb andt~e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] Gene_or_gene_productt-interceding-token ngrams: Rheb and activationt)interceding-token ngrams: of mTOR complext|e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tsc2'] >prep_by [lemma='AMPK'] Gene_or_gene_productt+e1: args2Role-mention-ngram: ERK CONTROLLEDt)interceding-token ngrams: , releasing thet"interceding-token ngrams: mTORC1 )t#CSSPATH: ROOT >xcomp ++ ROOT >nsubjt>e1: ents2Label-mention-ngram: cyclinE and GENE_OR_GENE_PRODUCTt,interceding-tokens-full-span: complex . Thistfe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlledtme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikk'] controller:Gene_or_gene_producttDe1: trigger-arg-path: phosphorylates >nsubj [lemma='ikk'] controllert)interceding-token ngrams: with inhibitiont,interceding-token ngrams: with inhibition oft*interceding-token ngrams: IKKa and IKKbetat)interceding-token ngrams: its clearance .t'interceding-token ngrams: and IKKbeta ,t1interceding-token ngrams: clearance . Furthermoret~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikk'] controller:Gene_or_gene_productt/interceding-token ngrams: regulating DNA damaget)interceding-token ngrams: , have opposingtje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikk'] controller:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylates >nsubj [lemma='ikk'] controller:Gene_or_gene_productt interceding-token ngrams: , havet"interceding-token ngrams: of IKK ,tinterceding-token ngrams: rolest$interceding-token ngrams: Htt , witht?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controller:Gene_or_gene_productt(interceding-token ngrams: damage inducedtXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikk'] controllert9e2: trigger-arg-path: blocking >nsubj >prep_of controllertWe2: trigger-arg-path: blocking >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlledt9CSSPATH: ROOT  ++ ROOT >dobj >prepc_in >ccomp >prepc_withtNe1: trigger-arg-path: phosphorylates >nsubj [lemma='ikk'] Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikk'] controllertHe2: trigger-arg-path: blocking >dobj >nn controlled:Gene_or_gene_productt(interceding-token ngrams: opposing rolest)interceding-token ngrams: cleavage of Httt1interceding-token ngrams: proteolytic cleavage oftle2: trigger-arg-path: Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlled:Gene_or_gene_productt"interceding-token ngrams: opposingt%interceding-token ngrams: clearance .t$interceding-token ngrams: kinases oft"interceding-token ngrams: of Htt ,tae2: trigger-arg-path: blocking >dobj [lemma='proteolysis'] >nn [lemma='htt'] Gene_or_gene_productt interceding-token ngrams: , IKKatpe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='proteolysis'] >nn [lemma='htt'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controller:Gene_or_gene_producttle2: trigger-arg-path: blocking >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlled:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] Gene_or_gene_productt1interceding-token ngrams: enhancing its clearancetue2: trigger-arg-path: blocking >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controller:Gene_or_gene_productt;e2: ents2Label-mention-ngram: blocking GENE_OR_GENE_PRODUCTt%e2: args2Role-mention-ngram: blockingt.interceding-token ngrams: proteolytic cleavagetke2: trigger-arg-path: blocking:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlledtSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikk'] Gene_or_gene_productt0e2: args2Role-mention-ngram: blocking CONTROLLEDtinterceding-token ngrams: IKKat_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikk'] Gene_or_gene_productt'interceding-token ngrams: its clearancet$interceding-token ngrams: IKK , IKKat)interceding-token ngrams: core kinases oft`e2: trigger-arg-path: blocking >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controllert$interceding-token ngrams: , IKKa andtMe2: trigger-arg-path: blocking:Positive_activation >nsubj >prep_of controllert interceding-token ngrams: , withtNe2: trigger-arg-path: blocking >nsubj >prep_of controller:Gene_or_gene_productt9e1: ents2Label-mention-ngram: mutant GENE_OR_GENE_PRODUCTtCe2: trigger-arg-path: blocking >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controller:Gene_or_gene_productt&interceding-token ngrams: core kinasest;e2: args2Role-mention-ngram: CONTROLLER blocking CONTROLLEDt-interceding-token ngrams: roles in regulatingt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT blockingt interceding-token ngrams: damaget+interceding-token ngrams: opposing roles int-interceding-token ngrams: induced proteolytict-interceding-token ngrams: have opposing rolest~e2: trigger-arg-path: blocking:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] Gene_or_gene_producttue2: trigger-arg-path: blocking:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] Gene_or_gene_producttbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ikk'] Gene_or_gene_producttinterceding-token ngrams: coret&e2: ents2Label-mention-ngram: blockingt#interceding-token ngrams: clearancet interceding-token ngrams: of HtttHe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates mutantt\e2: trigger-arg-path: blocking:Positive_activation >dobj >nn controlled:Gene_or_gene_producttbe2: trigger-arg-path: blocking:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt'interceding-token ngrams: in regulatingt+interceding-token ngrams: Furthermore , thet"interceding-token ngrams: IKKa andtinterceding-token ngrams: Httt3e2: trigger-arg-path: blocking >dobj >nn controlledt*interceding-token ngrams: the core kinasest,interceding-token ngrams: DNA damage inducedt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ikk'] controller:Gene_or_gene_productt$interceding-token ngrams: DNA damagetwe2: trigger-arg-path: Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlled:Gene_or_gene_producttke2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controllertte2: trigger-arg-path: blocking:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controllert?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controllert?interceding-tokens-full-span: , enhancing its clearance . Furthermore , the core kinases of IKK , IKKa and IKKbeta , have opposing roles in regulating DNA damage induced proteolytic cleavage of Htt , with inhibition oftje2: trigger-arg-path: blocking >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] Gene_or_gene_productt"interceding-token ngrams: roles intoe2: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controllertQe2: trigger-arg-path: blocking:Positive_activation >dobj >nn Gene_or_gene_productt$interceding-token ngrams: , the coret#interceding-token ngrams: IKKbeta ,tinterceding-token ngrams: Htt ,tse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikk'] Gene_or_gene_productt'interceding-token ngrams: have opposingt6interceding-token ngrams: induced proteolytic cleavaget4interceding-token ngrams: damage induced proteolytict?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] Gene_or_gene_productte2: trigger: blockingtHe1: ents2Label-mention-ngram: phosphorylates mutant GENE_OR_GENE_PRODUCTt0e2: args2Role-mention-ngram: CONTROLLER blockingt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] Gene_or_gene_producttinterceding-token ngrams: IKK ,t?e2: trigger-arg-path: blocking:Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] controller:Gene_or_gene_productt=e2: trigger-arg-path: blocking >dobj >nn Gene_or_gene_productt"interceding-token ngrams: the coret%interceding-token ngrams: proteolytict+interceding-token ngrams: , with inhibitiontUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ikk'] controllertGe2: trigger-arg-path: blocking:Positive_activation >dobj >nn controlledt interceding-token ngrams: of IKKtPe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT blocking GENE_OR_GENE_PRODUCTt(interceding-token ngrams: IKKbeta , havet)interceding-token ngrams: , enhancing itst3e1: ents2Label-mention-ngram: phosphorylates mutantt(interceding-token ngrams: regulating DNAtze2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlledtie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ikk'] controllert?e2: trigger-arg-path: blocking:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlled:Gene_or_gene_productt+interceding-token ngrams: in regulating DNAtWe2: trigger-arg-path: blocking:Positive_activation >nsubj >prep_of Gene_or_gene_productt(interceding-token ngrams: kinases of IKKtue2: trigger-arg-path: Positive_activation >nsubj [lemma='inhibition'] >prep_of [lemma='ikkbeta'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlled:Gene_or_gene_producttinterceding-token ngrams: IKKtbe2: trigger-arg-path: Positive_activation >dobj [lemma='proteolysis'] >nn [lemma='htt'] controlledt1interceding-token ngrams: activity . Consequentlyt,e1: args2Role-mention-ngram: GDP bound THEMEt_e2: trigger-arg-path: suppresses >nsubj [lemma='neurofibromin'] controller:Gene_or_gene_producttHe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppresses activationt1e2: args2Role-mention-ngram: downstream effectorstZe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of >prep_of controlled:FamilytZe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='neurofibromin'] controllertde2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='neurofibromin'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of >prep_of Familytme1: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt0e1: ents2Label-mention-ngram: inactive GDP boundt?e2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] Familyt?e2: trigger-arg-path: suppresses >dobj >prep_of >prep_of Familytoe1: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_producttoe1: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt}e2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] Familyt4e2: args2Role-mention-ngram: effectors of CONTROLLEDt^e2: trigger-arg-path: suppresses:Negative_activation >dobj >prep_of >prep_of controlled:Familyt'e1: ents2Label-mention-ngram: GDP boundt=e2: args2Role-mention-ngram: CONTROLLER suppresses activationt?e2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlled:Familyt?e2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlled:Familyt?e2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlledtue1: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt e1: args2Role-mention-ngram: GDPt?e2: trigger-arg-path: suppresses:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlledtCe2: trigger-arg-path: suppresses >dobj >prep_of >prep_of controlledtTe2: trigger-arg-path: suppresses >nsubj [lemma='neurofibromin'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: effectorst*e2: ents2Label-mention-ngram: effectors ofthe2: trigger-arg-path: Negative_activation >nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlledtWe2: trigger-arg-path: suppresses:Negative_activation >dobj >prep_of >prep_of controlledt2e2: ents2Label-mention-ngram: downstream effectorsthe2: trigger-arg-path: suppresses:Negative_activation >nsubj [lemma='neurofibromin'] Gene_or_gene_producttKinterceding-tokens-full-span: with its Ras-GTPase activity . Consequently ,t?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: downstream effectors oft?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlledt/interceding-token ngrams: Ras-GTPase activity .tie1: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_producttte2: trigger-arg-path: suppresses >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] Familytne2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of >prep_of controlled:Familytne2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='neurofibromin'] controllert)e1: args2Role-mention-ngram: inactive GDPt2e2: trigger-arg-path: suppresses >nsubj controllert6e2: ents2Label-mention-ngram: the downstream effectorstHe2: trigger-arg-path: Negative_activation >dobj >prep_of >prep_of FamilytZe1: trigger-arg-path: Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themetxe2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='neurofibromin'] Gene_or_gene_productt.e2: args2Role-mention-ngram: activation of thet$interceding-token ngrams: Ras-GTPasetFe2: trigger-arg-path: suppresses:Negative_activation >nsubj controllertxe2: trigger-arg-path: suppresses >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlledt5e2: args2Role-mention-ngram: the downstream effectorstoe2: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] FamilytSe2: trigger-arg-path: suppresses:Negative_activation >dobj >prep_of >prep_of Familyt&e2: args2Role-mention-ngram: effectorstSe2: trigger-arg-path: Negative_activation >dobj >prep_of >prep_of controlled:FamilytSe2: trigger-arg-path: Negative_activation >nsubj [lemma='neurofibromin'] controllert2e2: args2Role-mention-ngram: suppresses activationte2: trigger-arg-path: suppresses >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlled:Familyt1interceding-token ngrams: its Ras-GTPase activitytqe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themet)e2: args2Role-mention-ngram: effectors oft/e2: ents2Label-mention-ngram: activation of thet>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to inactivet.e2: args2Role-mention-ngram: of the downstreamt*e1: ents2Label-mention-ngram: inactive GDPtie1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themetce2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of >prep_of Familyt'CSSPATH: ROOT >prepc_by >ccomp ++ ROOT t,e1: args2Role-mention-ngram: to inactive GDPtLe2: trigger-arg-path: Negative_activation >dobj >prep_of >prep_of controlledt[e2: trigger-arg-path: suppresses:Negative_activation >nsubj controller:Gene_or_gene_producttge1: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_producttPe2: trigger-arg-path: suppresses:Negative_activation >nsubj Gene_or_gene_producttJe2: trigger-arg-path: suppresses >nsubj [lemma='neurofibromin'] controllertxe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: suppresses activation oft-interceding-token ngrams: Ras-GTPase activityt5e2: ents2Label-mention-ngram: downstream effectors oftGe2: trigger-arg-path: suppresses >nsubj controller:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=suppress >dobj >prep_of >prep_of controlledt/e2: ents2Label-mention-ngram: of the downstreamt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: effectors of SHAREDtse2: trigger-arg-path: suppresses:Negative_activation >nsubj [lemma='neurofibromin'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: GDPt.e1: ents2Label-mention-ngram: GDP bound SHAREDt&e1: args2Role-mention-ngram: GDP boundt3e2: ents2Label-mention-ngram: suppresses activationtge2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >prep_of >prep_of controlledt+e2: args2Role-mention-ngram: the downstreamtJe2: trigger-arg-path: suppresses >dobj >prep_of >prep_of controlled:Familyt,e2: ents2Label-mention-ngram: the downstreamt?e2: trigger-arg-path: suppresses:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlled:Familyt`e1: trigger-arg-path: bound:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themetnsubj Gene_or_gene_productt?e2: trigger-arg-path: suppresses:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='effector'] >prep_of [lemma='ra'] controlled:Familyt]e2: trigger-arg-path: Negative_activation >nsubj [lemma='neurofibromin'] Gene_or_gene_producttXe1: trigger-arg-path: bound >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] themet/e1: args2Role-mention-ngram: inactive GDP boundt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='conversion'] >prep_of [lemma='ras-gtp'] theme:Gene_or_gene_productt-interceding-token ngrams: with its Ras-GTPaset.e1: args2Role-mention-ngram: THEME to inactivet^e2: trigger-arg-path: suppresses:Negative_activation >nsubj [lemma='neurofibromin'] controllert(interceding-token ngrams: its Ras-GTPaset-e1: ents2Label-mention-ngram: to inactive GDPt5e2: args2Role-mention-ngram: suppresses activation oftUe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p110gamma'] controlledt*interceding-token ngrams: Ras can activatetbe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='p110gamma'] Gene_or_gene_productt'interceding-token ngrams: membrane , byt(interceding-token ngrams: the membrane ,tEe1: trigger-arg-path: activates >nsubj [lemma='ra'] controller:Familyt$interceding-token ngrams: modulationt#interceding-token ngrams: the leveltDe1: trigger-arg-path: activates >dobj [lemma='p110gamma'] controlledtEe1: trigger-arg-path: activates >dobj controlled:Gene_or_gene_producttYe1: trigger-arg-path: activates >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt.interceding-token ngrams: structural work thatt1e1: trigger-arg-path: activates >nsubj controllert%interceding-token ngrams: p110gamma ,tue2: trigger-arg-path: binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] themetme1: trigger-arg-path: activates:Positive_activation >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt/interceding-token ngrams: p110gamma without itst3interceding-token ngrams: allosteric modulation andt1interceding-token ngrams: supported by structuralt8e1: trigger-arg-path: activates >nsubj controller:Familyt&interceding-token ngrams: level of thetse1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p110gamma'] Gene_or_gene_productt>e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj Familytje1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='ra'] controller:Familyt#interceding-token ngrams: work thatt+interceding-token ngrams: view is supportedt+interceding-token ngrams: implying that Rast)interceding-token ngrams: structural worktYe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='ra'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='result'] >nn [lemma='p110gamma'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt>e1: trigger-arg-path: activates >nsubj [lemma='ra'] controllertinterceding-token ngrams: workt&interceding-token ngrams: This view istdobj controlled:Gene_or_gene_productt*CSSPATH: ROOT  ++ ROOT >agent >rcmod >dobjtce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='ra'] controllert"interceding-token ngrams: that hastNe1: trigger-arg-path: activates:Positive_activation >dobj Gene_or_gene_productt.interceding-token ngrams: and or reorientationt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='result'] >nn [lemma='p110gamma'] theme:Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='ra'] controllert?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] theme:Gene_or_gene_productt-interceding-token ngrams: or reorientation oft?e2: trigger-arg-path: binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] Gene_or_gene_productt.interceding-token ngrams: without its membranet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] themetinterceding-token ngrams: , byt_e1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='p110gamma'] Gene_or_gene_productt,interceding-token ngrams: activate p110gammat)interceding-token ngrams: , by allosterict_e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='ra'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] Gene_or_gene_productt4interceding-token ngrams: activate p110gamma withoutt2interceding-token ngrams: membrane translocation .te2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='result'] >nn [lemma='p110gamma'] themetinterceding-tokens-full-span: at the level of the membrane , by allosteric modulation and and or reorientation of the p110gamma , implying that Ras can activate p110gamma without its membrane translocation . This view is supported by structural work that has suggestedt2interceding-token ngrams: by allosteric modulationt'interceding-token ngrams: implying thatt*interceding-token ngrams: reorientation oft#interceding-token ngrams: p110gammat$interceding-token ngrams: structuraltNe1: trigger-arg-path: activates >dobj [lemma='p110gamma'] Gene_or_gene_productt&interceding-token ngrams: the level oft'interceding-token ngrams: work that hastinterceding-token ngrams: viewt0interceding-token ngrams: membrane translocationt%interceding-token ngrams: without itst*interceding-token ngrams: of the p110gammat:e1: trigger-arg-path: activates >dobj Gene_or_gene_producttRe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='ra'] controllert(interceding-token ngrams: modulation andtme2: trigger-arg-path: Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] themetNe1: trigger-arg-path: Positive_activation >dobj [lemma='p110gamma'] controlledtme2: trigger-arg-path: binding prep_to [lemma='result'] >nn [lemma='p110gamma'] themet?e2: trigger-arg-path: Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] theme:Gene_or_gene_productt'interceding-token ngrams: has suggestedt*interceding-token ngrams: or reorientationtXe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='p110gamma'] controlledt,interceding-token ngrams: that has suggestedt"interceding-token ngrams: that Rast!interceding-token ngrams: Ras cant$interceding-token ngrams: , implyingt4interceding-token ngrams: its membrane translocationt!interceding-token ngrams: view ist)interceding-token ngrams: translocation .t&interceding-token ngrams: at the levelt5e1: ents2Label-mention-ngram: SHARED activates SHAREDt/interceding-token ngrams: allosteric modulationt&interceding-token ngrams: its membranetAe1: trigger-arg-path: activates:Positive_activation >nsubj Familyt?e2: trigger-arg-path: binding:Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='ra'] Familyt|e2: trigger-arg-path: binding prep_to [lemma='result'] >nn [lemma='p110gamma'] Gene_or_gene_productt#interceding-token ngrams: This viewtLe1: trigger-arg-path: activates:Positive_activation >nsubj controller:Familyt&interceding-token ngrams: that Ras cant%interceding-token ngrams: . This viewt)interceding-token ngrams: the p110gamma ,tNe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='ra'] Familyt&interceding-token ngrams: can activatet.interceding-token ngrams: p110gamma , implyingt"interceding-token ngrams: implyingt-e1: trigger-arg-path: activates >nsubj Familyt)interceding-token ngrams: , implying thatt,interceding-token ngrams: by structural workt]e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:Familyt'interceding-token ngrams: by structuralt'interceding-token ngrams: by allosterict.interceding-token ngrams: translocation . Thistie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p110gamma'] controlledtRe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj FamilytVe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='ra'] controller:Familyt.interceding-token ngrams: reorientation of thet+interceding-token ngrams: p110gamma withouttIe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Familytce1: trigger-arg-path: Positive_activation >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt'interceding-token ngrams: the p110gammat?e2: trigger-arg-path: binding prep_to [lemma='result'] >nn [lemma='p110gamma'] theme:Gene_or_gene_productt0interceding-token ngrams: can activate p110gammat~e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='p110gamma'] controlled:Gene_or_gene_producttEe1: trigger-arg-path: activates:Positive_activation >nsubj controllert:e1: trigger-arg-path: activates >nsubj [lemma='ra'] FamilytXe1: trigger-arg-path: Positive_activation >dobj [lemma='p110gamma'] Gene_or_gene_productt,interceding-token ngrams: modulation and andt)interceding-token ngrams: of the membranet|e2: trigger-arg-path: Binding prep_to [lemma='result'] >nn [lemma='p110gamma'] Gene_or_gene_productt'interceding-token ngrams: reorientationt%interceding-token ngrams: evidence oftTe1: trigger-arg-path: Positive_activation >nsubj [lemma='Sprouty'] controller:Familyt1e1: trigger-arg-path: increases >nsubj controllertZe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Sprouty'] FamilytPe2: trigger-arg-path: interaction:Binding >prep_between [lemma='Sprouty'] FamilytMe2: trigger-arg-path: interaction:Binding >prep_between [lemma='PTP1B'] themet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] Gene_or_gene_producttWe1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='Sprouty'] controllert]e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj controller:Familytte2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTP1B'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: also increasestTe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Sprouty'] controllertVe2: trigger-arg-path: Binding >prep_between [lemma='PTP1B'] theme:Gene_or_gene_producttje1: trigger-arg-path: Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] Gene_or_gene_productte1: trigger-arg-path: increases:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlled:Gene_or_gene_productt^e1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='Sprouty'] controller:FamilytZe2: trigger-arg-path: interaction >prep_between [lemma='PTP1B'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Positive_activation >nsubj [lemma='Sprouty'] FamilytLe1: trigger-arg-path: increases:Positive_activation >nsubj controller:FamilytPinterceding-tokens-full-span: content . However , there is no evidence of directthe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Sprouty'] theme:Familyt>e1: trigger-arg-path: increases >dobj >nn Gene_or_gene_productt\e2: trigger-arg-path: interaction:Binding >prep_between [lemma='PTP1B'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlled:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn controlled:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED also increasest)interceding-token ngrams: However , theret6e1: args2Role-mention-ngram: also increases CONTROLLEDt(interceding-token ngrams: is no evidencet{e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlledt`e1: trigger-arg-path: increases >dobj [lemma='content'] >nn [lemma='ptp1b'] Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='content'] >nn [lemma='ptp1b'] controlled:Gene_or_gene_producttAe1: trigger-arg-path: increases:Positive_activation >nsubj Familytke1: trigger-arg-path: increases >dobj [lemma='content'] >nn [lemma='ptp1b'] controlled:Gene_or_gene_producttje1: trigger-arg-path: increases:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlledt[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Sprouty'] controller:Familytne2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTP1B'] Gene_or_gene_producttue1: trigger-arg-path: Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlled:Gene_or_gene_productt-e1: trigger-arg-path: increases >nsubj Familyt&CSSPATH: ROOT  ++ ROOT >nsubj >prep_oftGe2: trigger-arg-path: interaction >prep_between [lemma='Sprouty'] themetinterceding-token ngrams: not%interceding-token ngrams: no evidencetVe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj controllertDe2: trigger-arg-path: Binding >prep_between [lemma='Sprouty'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='PTP1B'] themet]e1: trigger-arg-path: increases:Positive_activation >dobj >nn controlled:Gene_or_gene_producttVe1: trigger-arg-path: increases >dobj [lemma='content'] >nn [lemma='ptp1b'] controlledt%interceding-token ngrams: there is not#interceding-token ngrams: content .t?e1: trigger-arg-path: increases >nsubj [lemma='Sprouty'] Familytinterceding-token ngrams: is notJe1: trigger-arg-path: increases >nsubj [lemma='Sprouty'] controller:Familytbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Sprouty'] Familytbe2: trigger-arg-path: interaction:Binding >prep_between [lemma='PTP1B'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interaction >prep_between [lemma='PTP1B'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Sprouty'] theme:FamilytVe2: trigger-arg-path: interaction:Binding >prep_between [lemma='Sprouty'] theme:Familyt(interceding-token ngrams: no evidence oftOe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='Sprouty'] FamilytEe1: trigger-arg-path: increases:Positive_activation >nsubj controllertqe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='content'] >nn [lemma='ptp1b'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj FamilytRe1: trigger-arg-path: increases:Positive_activation >dobj >nn Gene_or_gene_producttCe2: trigger-arg-path: Binding >prep_between [lemma='Sprouty'] themethe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='Sprouty'] controllertge1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='content'] >nn [lemma='ptp1b'] controlledtYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='Sprouty'] themetSe1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='Sprouty'] Familyt+e1: args2Role-mention-ngram: also increasestNe2: trigger-arg-path: interaction >prep_between [lemma='Sprouty'] theme:FamilytJe2: trigger-arg-path: Binding >prep_between [lemma='Sprouty'] theme:Familyt6e1: args2Role-mention-ngram: CONTROLLER also increasestoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='Sprouty'] controller:Familytce1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >nn Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTP1B'] themetOe2: trigger-arg-path: interaction:Binding >prep_between [lemma='Sprouty'] themetAe2: trigger-arg-path: Binding >prep_between [lemma='PTP1B'] themet!interceding-token ngrams: contenttEe2: trigger-arg-path: interaction >prep_between [lemma='PTP1B'] themet3e1: ents2Label-mention-ngram: also increases SHAREDtCe1: trigger-arg-path: increases >nsubj [lemma='Sprouty'] controllertle2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTP1B'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Positive_activation >nsubj [lemma='Sprouty'] controllertPe2: trigger-arg-path: Binding >prep_between [lemma='PTP1B'] Gene_or_gene_producttte1: trigger-arg-path: increases:Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] Gene_or_gene_producttHe2: trigger-arg-path: interaction >prep_between [lemma='Sprouty'] Familytde1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='Sprouty'] Familyt8e1: trigger-arg-path: increases >nsubj controller:Familyt+interceding-token ngrams: content . Howevert#interceding-token ngrams: of directt,interceding-token ngrams: evidence of directtZe1: trigger-arg-path: lemmatizedTrigger=increase >dobj >nn controlled:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='PTP1B'] Gene_or_gene_producttIe1: trigger-arg-path: increases >dobj >nn controlled:Gene_or_gene_productt`e1: trigger-arg-path: Positive_activation >dobj [lemma='content'] >nn [lemma='ptp1b'] controlledtae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='Sprouty'] themetZe2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_producttFe2: trigger-arg-path: induced >nsubj [lemma='ha'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: beta1-integrin expression andtbe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] controller:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass controlledt1e1: ents2Label-mention-ngram: of the cytoskeletaltFe2: trigger-arg-path: Negative_regulation >ccomp >nsubjpass controlledt]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt|e2: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: signaling increasedtWe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass Phosphorylationt2e1: ents2Label-mention-ngram: cortactin and SHAREDt4e1: ents2Label-mention-ngram: proteins cortactin andtNe2: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass controlledtee1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: beta1-integrin expressiontPe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] controllertie2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj controllert~e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] PhosphorylationtPe2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass PhosphorylationtAe1: ents2Label-mention-ngram: SHARED induced GENE_OR_GENE_PRODUCTt.e1: ents2Label-mention-ngram: the cytoskeletalt+e1: ents2Label-mention-ngram: cortactin andtve2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_producttSe2: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass Phosphorylationt:e2: trigger-arg-path: induced >ccomp >nsubjpass controlledtae2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] controllertee2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_producttRe2: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: proteins cortactintVe2: trigger-arg-path: Negative_regulation >ccomp >nsubjpass controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationtme2: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt?e2: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:PhosphorylationtFe1: trigger-arg-path: induced >nsubj [lemma='ha'] Gene_or_gene_producttZe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] controllert^e2: trigger-arg-path: induced:Negative_regulation >ccomp >nsubjpass controlled:Phosphorylationtnsubj [lemma='ha'] controllertMe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] controllert@e1: ents2Label-mention-ngram: signaling increased beta1-integrintke2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass controlled:Phosphorylationthe2: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_producttKe2: trigger-arg-path: Negative_regulation >ccomp >nsubjpass Phosphorylationt^e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj Gene_or_gene_producttAe1: ents2Label-mention-ngram: increased beta1-integrin expressiontWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp >nsubjpass controlledtMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] controllert,e1: ents2Label-mention-ngram: beta1-integrint3e1: ents2Label-mention-ngram: cytoskeletal proteinst4e1: ents2Label-mention-ngram: activation and inducedt[e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp >nsubjpass controlled:Phosphorylationt?e2: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] PhosphorylationtPe2: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] controllert?e2: trigger-arg-path: induced >ccomp >nsubjpass Phosphorylationtye2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] controllertDe1: ents2Label-mention-ngram: induced GENE_OR_GENE_PRODUCT signalingtFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT signaling increasedt7e1: ents2Label-mention-ngram: the cytoskeletal proteinstCe2: trigger-arg-path: induced:Negative_regulation >nsubj controllertQe2: trigger-arg-path: induced >nsubj [lemma='ha'] controller:Gene_or_gene_producttMe2: trigger-arg-path: induced:Negative_regulation >nsubj Gene_or_gene_producttye2: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt'e1: ents2Label-mention-ngram: cortactint0e1: ents2Label-mention-ngram: and activation andtHe2: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] controllert6e1: ents2Label-mention-ngram: increased beta1-integrintXe2: trigger-arg-path: induced:Negative_regulation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt9e1: ents2Label-mention-ngram: and induced phosphorylationtbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='ha'] controller:Gene_or_gene_productt=e1: ents2Label-mention-ngram: cytoskeletal proteins cortactint*e1: ents2Label-mention-ngram: cytoskeletalt]e2: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_producttJe2: trigger-arg-path: induced >ccomp >nsubjpass controlled:Phosphorylationtxe2: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:PhosphorylationtQe1: trigger-arg-path: induced >nsubj [lemma='ha'] controller:Gene_or_gene_producttnsubj [lemma='ha'] controllertte2: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledt7e1: ents2Label-mention-ngram: expression and activationtKe1: ents2Label-mention-ngram: anti-proliferative GPCRs GENE_OR_GENE_PRODUCTtbe2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr1'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfr'] themetMe1: trigger-arg-path: interaction:Binding >prep_between [lemma='sstr5'] themetle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr5'] theme:Gene_or_gene_producttRe2: trigger-arg-path: complexes:Binding amod theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr1'] theme:Gene_or_gene_productt8e2: trigger-arg-path: complexes >nn [lemma='egfr'] themetHe2: trigger-arg-path: Binding amod theme:Gene_or_gene_productt;e1: args2Role-mention-ngram: anti-proliferative GPCRs THEMEt@e2: trigger-arg-path: complexes:Binding >nn [lemma='egfr'] themetUe2: trigger-arg-path: complexes:Binding >nn [lemma='egfr'] theme:Gene_or_gene_producttprep_between [lemma='sstr5'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='egfr'] themet?e2: trigger-arg-path: lemmatizedTrigger=complex amod [lemma='heterodimeric'] theme:Gene_or_gene_productt=e2: trigger-arg-path: complexes:Binding amod themetZe1: trigger-arg-path: interaction >prep_between [lemma='sstr1'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: the anti-proliferativetAe1: trigger-arg-path: Binding >prep_between [lemma='sstr1'] themetqe2: trigger-arg-path: complexes amod [lemma='heterodimeric'] theme:Gene_or_gene_productt"interceding-token ngrams: EGFR hast_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfr'] Gene_or_gene_producttVe1: trigger-arg-path: Binding >prep_between [lemma='sstr5'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_between [lemma='sstr5'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='heterodimeric'] theme:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=complex amod themet4e1: ents2Label-mention-ngram: the anti-proliferativetne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr5'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfr'] theme:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfr'] Gene_or_gene_productt(e1: args2Role-mention-ngram: GPCRs THEMEt&interceding-token ngrams: and EGFR hast5e1: ents2Label-mention-ngram: interaction between thet$interceding-token ngrams: , and EGFRt/e1: args2Role-mention-ngram: anti-proliferativet6e1: ents2Label-mention-ngram: anti-proliferative GPCRst_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr1'] themetOe2: trigger-arg-path: complexes:Binding >nn [lemma='egfr'] Gene_or_gene_productt5e2: trigger-arg-path: complexes amod themet\e2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='egfr'] Gene_or_gene_producttBe2: trigger-arg-path: Binding amod Gene_or_gene_producttse2: trigger-arg-path: complexes:Binding amod [lemma='heterodimeric'] Gene_or_gene_producttEe1: trigger-arg-path: interaction >prep_between [lemma='sstr5'] themet/interceding-token ngrams: described . Preformedt,interceding-token ngrams: has been describedtWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr5'] themetbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='sstr1'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='egfr'] themet9e1: args2Role-mention-ngram: the anti-proliferative GPCRstprep_between [lemma='sstr1'] themetGe2: trigger-arg-path: complexes >nn [lemma='egfr'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='egfr'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: anti-proliferative GPCRstTe1: trigger-arg-path: interaction >prep_between [lemma='sstr1'] Gene_or_gene_producttZe1: trigger-arg-path: interaction >prep_between [lemma='sstr5'] theme:Gene_or_gene_producttZe2: trigger-arg-path: Binding amod [lemma='heterodimeric'] themet8e1: ents2Label-mention-ngram: GPCRs GENE_OR_GENE_PRODUCTt"interceding-token ngrams: and EGFRt0e1: ents2Label-mention-ngram: anti-proliferativetfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr5'] Gene_or_gene_productt\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='sstr5'] Gene_or_gene_productt#interceding-token ngrams: Preformedtoe2: trigger-arg-path: Binding amod [lemma='heterodimeric'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=complex amod [lemma='heterodimeric'] Gene_or_gene_productt%interceding-token ngrams: . Preformedtte1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr5'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complexes amod theme:Gene_or_gene_productt4e1: args2Role-mention-ngram: interaction between thetne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr1'] Gene_or_gene_productt*interceding-token ngrams: been described .t"e1: args2Role-mention-ngram: GPCRst(interceding-token ngrams: been describedt#e1: ents2Label-mention-ngram: GPCRst;e1: args2Role-mention-ngram: between the anti-proliferativetPe1: trigger-arg-path: Binding >prep_between [lemma='sstr1'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='heterodimeric'] themetie2: trigger-arg-path: Binding amod [lemma='heterodimeric'] Gene_or_gene_productt\e2: trigger-arg-path: complexes amod [lemma='heterodimeric'] themet%interceding-token ngrams: described .t'interceding-token ngrams: EGFR has beent)e1: ents2Label-mention-ngram: between thetAe1: trigger-arg-path: Binding >prep_between [lemma='sstr5'] themetTe2: trigger-arg-path: lemmatizedTrigger=complex amod Gene_or_gene_producttDe2: trigger-arg-path: complexes amod Gene_or_gene_producttGinterceding-tokens-full-span: , and EGFR has been described . Preformedt3e2: trigger-arg-path: Binding amod themetVe1: trigger-arg-path: Binding >prep_between [lemma='sstr1'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complexes:Binding amod Gene_or_gene_producttMe2: trigger-arg-path: complexes >nn [lemma='egfr'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr1'] theme:Gene_or_gene_producttbe1: trigger-arg-path: interaction:Binding >prep_between [lemma='sstr5'] theme:Gene_or_gene_producttde2: trigger-arg-path: complexes:Binding amod [lemma='heterodimeric'] themetMe2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod themetle2: trigger-arg-path: lemmatizedTrigger=complex amod [lemma='heterodimeric'] themetEe1: trigger-arg-path: interaction >prep_between [lemma='sstr1'] themet:e1: ents2Label-mention-ngram: the anti-proliferative GPCRstye2: trigger-arg-path: complexes:Binding amod [lemma='heterodimeric'] theme:Gene_or_gene_productt\e1: trigger-arg-path: interaction:Binding >prep_between [lemma='sstr1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='sstr1'] themetke2: trigger-arg-path: complexes amod [lemma='heterodimeric'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=complex amod theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: GPCRs THEME andt?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding amod [lemma='heterodimeric'] Gene_or_gene_productt(e1: args2Role-mention-ngram: between thet_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='sstr5'] themet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='egfr'] theme:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj [lemma='ha'] controlledt/e2: ents2Label-mention-ngram: was attenuated bytEe2: trigger-arg-path: attenuated >agent >prep_of Gene_or_gene_producttae2: trigger-arg-path: attenuated:Negative_regulation nsubj controlled:Negative_regulationt(e2: ents2Label-mention-ngram: attenuatedt,e1: ents2Label-mention-ngram: was attenuatedt1e1: ents2Label-mention-ngram: depletion of SHAREDtnsubj controlledt?e2: trigger-arg-path: lemmatizedTrigger=attenuate >agent [lemma='depletion'] >prep_of [lemma='cd44'] controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj [lemma='ha'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controller:Gene_or_gene_producttie2: trigger-arg-path: Negative_regulation nsubj [lemma='ha'] Negative_regulationt'e2: args2Role-mention-ngram: attenuatedtMe2: trigger-arg-path: attenuated nsubj controlled:Negative_regulationt*e2: args2Role-mention-ngram: attenuated byt,e2: ents2Label-mention-ngram: was attenuatedt+e2: args2Role-mention-ngram: was attenuatedtte2: trigger-arg-path: attenuated:Negative_regulation nsubj [lemma='ha'] Negative_regulationtje2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=attenuate >agent >prep_of Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=attenuate >agent [lemma='depletion'] >prep_of [lemma='cd44'] controllertLe2: trigger-arg-path: lemmatizedTrigger=attenuate >agent >prep_of controllert4e2: args2Role-mention-ngram: attenuated by depletiont|e2: trigger-arg-path: Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controller:Gene_or_gene_productte2: trigger-arg-path: attenuated:Negative_regulation nsubj [lemma='ha'] controlled:Negative_regulationt`e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent >prep_of controllert+e2: ents2Label-mention-ngram: attenuated bytqe2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj [lemma='ha'] Negative_regulationt9e2: trigger-arg-path: attenuated nsubj controlledte2: trigger: attenuatedt1e2: ents2Label-mention-ngram: depletion of SHAREDt5e1: ents2Label-mention-ngram: attenuated by depletiont8e1: ents2Label-mention-ngram: SHARED phosphorylation wast?e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj [lemma='ha'] controlled:Negative_regulationtOe2: trigger-arg-path: attenuated:Negative_regulation >agent >prep_of controllert)e2: args2Role-mention-ngram: by depletiontBe2: trigger-arg-path: attenuated nsubj Negative_regulationthe2: trigger-arg-path: attenuated >agent [lemma='depletion'] >prep_of [lemma='cd44'] Gene_or_gene_producttVe2: trigger-arg-path: Negative_regulation nsubj controlled:Negative_regulationtke2: trigger-arg-path: attenuated nsubj [lemma='ha'] controlled:Negative_regulationt`trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp e2:attenuated:Negative_regulationt(e1: ents2Label-mention-ngram: attenuatedtse2: trigger-arg-path: attenuated >agent [lemma='depletion'] >prep_of [lemma='cd44'] controller:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj Negative_regulationt5e2: ents2Label-mention-ngram: attenuated by depletiontccomp [lemma='attenuate'] e2:attenuated:Negative_regulationtWe2: trigger-arg-path: attenuated nsubj [lemma='ha'] controlledt*e1: ents2Label-mention-ngram: depletion oft^e2: trigger-arg-path: attenuated >agent [lemma='depletion'] >prep_of [lemma='cd44'] controllertke2: trigger-arg-path: attenuated:Negative_regulation nsubj [lemma='ha'] controlledt+e1: ents2Label-mention-ngram: attenuated bytte2: trigger-arg-path: Negative_regulation nsubj [lemma='ha'] controlled:Negative_regulationt*e2: ents2Label-mention-ngram: depletion oft'e2: ents2Label-mention-ngram: depletiontue2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent >prep_of controller:Gene_or_gene_producttre2: trigger-arg-path: attenuated:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controllert&e2: args2Role-mention-ngram: depletiont|e2: trigger-arg-path: attenuated:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] Gene_or_gene_productt,e2: args2Role-mention-ngram: by depletion oftYe2: trigger-arg-path: attenuated:Negative_regulation >agent >prep_of Gene_or_gene_producttge2: trigger-arg-path: Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controllertDe2: trigger-arg-path: Negative_regulation >agent >prep_of controllertye2: trigger-arg-path: lemmatizedTrigger=attenuate >agent [lemma='depletion'] >prep_of [lemma='cd44'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: was attenuated bytJe2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj controlledtae2: trigger-arg-path: lemmatizedTrigger=attenuate >agent >prep_of controller:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj Negative_regulationtVe2: trigger-arg-path: attenuated:Negative_regulation nsubj Negative_regulationtYe2: trigger-arg-path: Negative_regulation >agent >prep_of controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: depletion of CONTROLLERt?e2: trigger-arg-path: attenuated:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controller:Gene_or_gene_productt`e2: trigger-arg-path: Negative_regulation nsubj [lemma='ha'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj [lemma='ha'] Negative_regulationt)e2: args2Role-mention-ngram: depletion oft-e1: ents2Label-mention-ngram: by depletion oftPe2: trigger-arg-path: attenuated >agent >prep_of controller:Gene_or_gene_productt`e2: trigger-arg-path: attenuated nsubj [lemma='ha'] Negative_regulationt*e1: ents2Label-mention-ngram: by depletiont^e2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj controlled:Negative_regulationt^e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj controlledt.e2: args2Role-mention-ngram: was attenuated bytKe2: trigger-arg-path: Negative_regulation nsubj Negative_regulationt*e2: ents2Label-mention-ngram: by depletiont|e2: trigger-arg-path: lemmatizedTrigger=attenuate nsubj [lemma='ha'] controlled:Negative_regulationt8e2: ents2Label-mention-ngram: SHARED phosphorylation wast;e2: trigger-arg-path: attenuated >agent >prep_of controllertre2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation nsubj controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=attenuate:Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] controllertNe2: trigger-arg-path: Negative_regulation >agent >prep_of Gene_or_gene_productt6e2: args2Role-mention-ngram: CONTROLLED was attenuatedtqe2: trigger-arg-path: Negative_regulation >agent [lemma='depletion'] >prep_of [lemma='cd44'] Gene_or_gene_producttde2: trigger-arg-path: attenuated:Negative_regulation >agent >prep_of controller:Gene_or_gene_producttBe2: trigger-arg-path: Negative_regulation nsubj controlledt2e1: args2Role-mention-ngram: of THEME specificallyt'e2: ents2Label-mention-ngram: GST alonetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] themetue1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] Gene_or_gene_productt&e2: args2Role-mention-ngram: GST alonet/e1: trigger-arg-path: bound:Binding >nsubj Sitet,e1: trigger-arg-path: bound >nsubj site:Sitet5e1: args2Role-mention-ngram: specifically bound THEMEtUe1: trigger-arg-path: Binding >dobj [lemma='ras-gtpgamma'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME nor GSTt e2: args2Role-mention-ngram: nort5e1: trigger-arg-path: bound >nsubj [lemma='rbd'] Sitetle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtpgamma'] theme:Gene_or_gene_producttRe2: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] themet[e1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtpgamma'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt"e2: args2Role-mention-ngram: alonet^e1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='raf'] themet#e2: ents2Label-mention-ngram: alonetde1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] theme:Gene_or_gene_producttUe1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtpgamma'] Gene_or_gene_producttYe2: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt=e1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] sitet-e2: args2Role-mention-ngram: alone interactedtwe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='raf'] Gene_or_gene_productt!e2: ents2Label-mention-ngram: GSTtBe1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT specificallytKe2: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] themetbe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] Gene_or_gene_producttge2: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt#interceding-token ngrams: . Neithertde1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtpgamma'] theme:Gene_or_gene_productt`e2: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT specifically boundt>e1: trigger-arg-path: bound >dobj [lemma='ras-gtpgamma'] themet/e1: args2Role-mention-ngram: specifically boundtUe2: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttZe2: trigger-arg-path: interacted:Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: specifically boundt%e2: ents2Label-mention-ngram: nor GSTtRe2: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themetfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtpgamma'] Gene_or_gene_producttEe1: ents2Label-mention-ngram: specifically bound GENE_OR_GENE_PRODUCTtbe1: trigger-arg-path: bound >nsubj [lemma='rbd'] >prep_of [lemma='raf'] theme:Gene_or_gene_productt@e1: trigger-arg-path: Binding >dobj [lemma='ras-gtpgamma'] themetje2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_productt=e1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] SitetSe1: trigger-arg-path: bound >dobj [lemma='ras-gtpgamma'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: alone interacted witht?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT specificallyt\e1: trigger-arg-path: bound >nsubj [lemma='rbd'] >prep_of [lemma='raf'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themet^e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtpgamma'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttFe1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtpgamma'] themet1e2: args2Role-mention-ngram: GST alone interactedt&e2: args2Role-mention-ngram: THEME nort'e1: trigger-arg-path: bound >nsubj sitetae2: trigger-arg-path: interacted:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT nortOe1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] themet{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >prep_of [lemma='raf'] theme:Gene_or_gene_productt_e2: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: GST alone interactedtVe2: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ras-gdp'] themet4e1: trigger-arg-path: bound:Binding >nsubj site:Sitet/e1: args2Role-mention-ngram: THEME specificallytWe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtpgamma'] themetde1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] Gene_or_gene_producttBe2: ents2Label-mention-ngram: interacted with GENE_OR_GENE_PRODUCTtje1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] theme:Gene_or_gene_productt e2: args2Role-mention-ngram: GSTt:e1: trigger-arg-path: bound >nsubj [lemma='rbd'] site:SitetOe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtpgamma'] themet'e1: trigger-arg-path: bound >nsubj SitetMe1: trigger-arg-path: bound >nsubj [lemma='rbd'] >prep_of [lemma='raf'] themet*e2: args2Role-mention-ngram: nor GST alonet/e1: trigger-arg-path: bound:Binding >nsubj sitet$e2: args2Role-mention-ngram: nor GSTtOe2: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] Gene_or_gene_productt\e2: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_producttJe2: trigger-arg-path: interacted >nsubj [lemma='gst-pi3kc2beta-rbd'] themet!interceding-token ngrams: Neithert!e2: ents2Label-mention-ngram: nortMe1: trigger-arg-path: bound >dobj [lemma='ras-gtpgamma'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >dobj [lemma='ras-gtpgamma'] Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] themetXe2: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interacted >prep_with [lemma='ras-gdp'] themet:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT nor GSTt+e2: ents2Label-mention-ngram: nor GST alonetUe1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] >prep_of [lemma='raf'] themetBe1: trigger-arg-path: bound:Binding >nsubj [lemma='rbd'] site:Sitetqe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='gst-pi3kc2beta-rbd'] Gene_or_gene_productt5e1: trigger-arg-path: bound >nsubj [lemma='rbd'] sitet'interceding-tokens-full-span: . NeithertSe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ras-gdp'] themet5e1: args2Role-mention-ngram: THEME specifically boundt.e2: ents2Label-mention-ngram: alone interactedt2e2: args2Role-mention-ngram: alone interacted witht@e2: trigger-arg-path: Binding >prep_with [lemma='ras-gdp'] themetoe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='gst-pi3kc2beta-rbd'] theme:Gene_or_gene_productt;e2: trigger-arg-path: binds nn Gene_or_gene_productt@e2: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] themetIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] themetLe2: trigger-arg-path: lemmatizedTrigger=bind nn Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_to [lemma='p73'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn themetIe2: trigger-arg-path: binds:Binding nn theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] Gene_or_gene_productt;e1: trigger-arg-path: binds nn Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] theme:Gene_or_gene_producttOe2: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind nn theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: , that bindstGe1: trigger-arg-path: binds >prep_to [lemma='p73'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: SHARED 1 NQO1t+e1: ents2Label-mention-ngram: that binds tot=e1: trigger-arg-path: Binding nn Gene_or_gene_producttYe2: trigger-arg-path: Binding nn [lemma='quinone'] themetOe2: trigger-arg-path: Binding >prep_to [lemma='p73'] theme:Gene_or_gene_producttYe1: trigger-arg-path: Binding nn [lemma='quinone'] themet=e2: trigger-arg-path: Binding nn Gene_or_gene_productt,e2: trigger-arg-path: binds nn themet#e1: args2Role-mention-ngram: NQO1 ,t$e2: ents2Label-mention-ngram: NQO1 ,tpe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] themetLe1: trigger-arg-path: lemmatizedTrigger=bind nn Gene_or_gene_producttAe2: trigger-arg-path: binds nn theme:Gene_or_gene_productt.e1: trigger-arg-path: Binding nn themetne2: trigger-arg-path: Binding nn [lemma='quinone'] theme:Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_to [lemma='p73'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] themetCe2: trigger-arg-path: binds:Binding nn Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn theme:Gene_or_gene_productt_e1: trigger-arg-path: binds:Binding nn [lemma='quinone'] themet%e2: args2Role-mention-ngram: 1 NQO1 ,twe1: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] Gene_or_gene_productt4e1: trigger-arg-path: binds:Binding nn themet:e2: trigger-arg-path: Binding >prep_to [lemma='p73'] themet)e2: args2Role-mention-ngram: THEME 1 NQO1t!e2: args2Role-mention-ngram: NQO1tWe1: trigger-arg-path: binds nn [lemma='quinone'] themetIe1: trigger-arg-path: binds:Binding nn theme:Gene_or_gene_producttGe2: trigger-arg-path: binds >prep_to [lemma='p73'] Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] themet"e1: ents2Label-mention-ngram: NQO1the1: trigger-arg-path: Binding nn [lemma='quinone'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] themet)e1: args2Role-mention-ngram: , that bindstwe2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: NQO1 , thatt*e1: args2Role-mention-ngram: that binds tot#e2: args2Role-mention-ngram: NQO1 ,tfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: that binds totte2: trigger-arg-path: binds:Binding nn [lemma='quinone'] theme:Gene_or_gene_productt}e1: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] theme:Gene_or_gene_producttne2: trigger-arg-path: binds:Binding nn [lemma='quinone'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: that bindst`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] Gene_or_gene_producttfe2: trigger-arg-path: binds nn [lemma='quinone'] Gene_or_gene_productt%e1: args2Role-mention-ngram: 1 NQO1 ,t+e1: ents2Label-mention-ngram: SHARED 1 NQO1tEe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn themetRe1: trigger-arg-path: lemmatizedTrigger=bind nn theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: 1 NQO1 ,te2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: 1 NQO1 ,t'e2: args2Role-mention-ngram: that bindst+shortest-path: nn themet8e1: trigger-arg-path: binds >prep_to [lemma='p73'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] theme:Gene_or_gene_productt"e2: ents2Label-mention-ngram: NQO1t)e1: args2Role-mention-ngram: THEME 1 NQO1t=e1: trigger-arg-path: lemmatizedTrigger=bind nn themet^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p73'] theme:Gene_or_gene_productt$e1: ents2Label-mention-ngram: , thatt(e2: args2Role-mention-ngram: NQO1 , thatt+e2: ents2Label-mention-ngram: that binds tot$e1: ents2Label-mention-ngram: 1 NQO1t)e1: ents2Label-mention-ngram: NQO1 , thatt*e1: ents2Label-mention-ngram: , that bindsthe2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] themete1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] Gene_or_gene_producttCe1: trigger-arg-path: Binding nn theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: , that bindst$e2: ents2Label-mention-ngram: 1 NQO1tle2: trigger-arg-path: binds nn [lemma='quinone'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] theme:Gene_or_gene_producttle1: trigger-arg-path: binds nn [lemma='quinone'] theme:Gene_or_gene_productt#e1: args2Role-mention-ngram: 1 NQO1tMe1: trigger-arg-path: binds >prep_to [lemma='p73'] theme:Gene_or_gene_productt_e2: trigger-arg-path: binds:Binding nn [lemma='quinone'] themetne1: trigger-arg-path: Binding nn [lemma='quinone'] theme:Gene_or_gene_productt.e2: trigger-arg-path: Binding nn themethe1: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] themet'e1: args2Role-mention-ngram: that bindst#e1: args2Role-mention-ngram: , thattWe2: trigger-arg-path: binds nn [lemma='quinone'] themetfe1: trigger-arg-path: binds nn [lemma='quinone'] Gene_or_gene_producttAe1: trigger-arg-path: binds nn theme:Gene_or_gene_producttMe2: trigger-arg-path: binds >prep_to [lemma='p73'] theme:Gene_or_gene_productt(e1: args2Role-mention-ngram: NQO1 , thattIe2: trigger-arg-path: Binding >prep_to [lemma='p73'] Gene_or_gene_producttCe1: trigger-arg-path: binds:Binding nn Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_to [lemma='p73'] themet(e1: ents2Label-mention-ngram: that bindstpe2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='quinone'] themette1: trigger-arg-path: binds:Binding nn [lemma='quinone'] theme:Gene_or_gene_productt,e1: trigger-arg-path: binds nn themet#e2: args2Role-mention-ngram: 1 NQO1t4e2: trigger-arg-path: binds:Binding nn themet$e1: ents2Label-mention-ngram: NQO1 ,t`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p73'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='quinone'] theme:Gene_or_gene_productt8e2: trigger-arg-path: binds >prep_to [lemma='p73'] themetZe2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: NQO1tne1: trigger-arg-path: binds:Binding nn [lemma='quinone'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding nn Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn Gene_or_gene_producttCe2: trigger-arg-path: Binding nn theme:Gene_or_gene_producttOe1: trigger-arg-path: binds:Binding >prep_to [lemma='p73'] Gene_or_gene_productthe2: trigger-arg-path: Binding nn [lemma='quinone'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: phosphorylates MCL-1 andt,interceding-token ngrams: GSK-3beta mediatedtoe2: trigger-arg-path: phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] Gene_or_gene_productt'interceding-token ngrams: mitochondrialt_e1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk-3beta'] controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3beta'] controllert+interceding-token ngrams: of MCL-1 promotedt-interceding-token ngrams: targets . GSK-3betat^e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk-3beta'] controllert?interceding-tokens-full-span: amongst other mitochondrial targets . GSK-3beta mediated phosphorylation of MCL-1 promoted its degradation and increased apoptosis , whilet~e2: trigger-arg-path: Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controller:Gene_or_gene_productt/interceding-token ngrams: mitochondrial targetst?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] Gene_or_gene_productt-interceding-token ngrams: other mitochondrialtye1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3beta'] Gene_or_gene_productt2interceding-token ngrams: mediated phosphorylationt2e1: ents2Label-mention-ngram: phosphorylates MCL-1t?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] Gene_or_gene_productt-interceding-token ngrams: increased apoptosistGe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates MCL-1t.interceding-token ngrams: . GSK-3beta mediatedt'interceding-token ngrams: amongst othert5interceding-token ngrams: other mitochondrial targetstse1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk-3beta'] controller:Gene_or_gene_productt#e1: ents2Label-mention-ngram: MCL-1t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3beta'] controllertwe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controllert#interceding-token ngrams: targets .t+CSSPATH: ROOT  ++ ROOT >ccomp >advcl >nsubjt2interceding-token ngrams: phosphorylation of MCL-1t)interceding-token ngrams: its degradationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='gsk-3beta'] controller:Gene_or_gene_productthe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='gsk-3beta'] Gene_or_gene_productt&interceding-token ngrams: promoted itst.e1: ents2Label-mention-ngram: MCL-1 and SHAREDt1interceding-token ngrams: and increased apoptosist"interceding-token ngrams: of MCL-1tJe1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk-3beta'] controllert5interceding-token ngrams: amongst other mitochondrialt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] Gene_or_gene_producttse2: trigger-arg-path: Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] Gene_or_gene_producttee2: trigger-arg-path: phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controllert(interceding-token ngrams: MCL-1 promotedtye2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controllert2interceding-token ngrams: promoted its degradationtee1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3beta'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='gsk-3beta'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3beta'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controllertde1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controller:Gene_or_gene_productt!interceding-token ngrams: amongstt'e1: ents2Label-mention-ngram: MCL-1 andt,interceding-token ngrams: MCL-1 promoted itstprep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controllertze2: trigger-arg-path: phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='vdac'] >prep_by [lemma='gsk-3beta'] controller:Gene_or_gene_productt/interceding-token ngrams: increased apoptosis ,t!interceding-token ngrams: targetstTe1: trigger-arg-path: phosphorylates >nsubj [lemma='gsk-3beta'] Gene_or_gene_producttYe1: trigger-arg-path: Positive_regulation >nsubj [lemma='gsk-3beta'] Gene_or_gene_producttinterceding-token ngrams: MCL-1t-interceding-token ngrams: its degradation andt%interceding-token ngrams: chromatin .tKe1: trigger-arg-path: interacts >nsubj [lemma='dnmt1'] Gene_or_gene_productt$interceding-token ngrams: protease (tUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='dnmt1'] themetze2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='tip60'] controller:Gene_or_gene_productt.interceding-token ngrams: associated ubiquitintYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tip60'] themet,interceding-token ngrams: ubiquitin specifict%interceding-token ngrams: RING fingert'interceding-token ngrams: , herpesvirust!interceding-token ngrams: ( HAUSPt!interceding-token ngrams: ( UHRF1t5interceding-token ngrams: ubiquitin specific proteasetKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='tip60'] controllert"interceding-token ngrams: and PCNAtinterceding-token ngrams: PCNAtne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tip60'] theme:Gene_or_gene_producttinterceding-token ngrams: PHDt0interceding-token ngrams: herpesvirus associatedt=e1: args2Role-mention-ngram: interacts with acetyltransferasetje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='dnmt1'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: physically interactst%interceding-token ngrams: domains 1 (t/e1: ents2Label-mention-ngram: SHARED physicallytYe2: trigger-arg-path: promotes:Positive_regulation >nsubj controller:Gene_or_gene_productt"interceding-token ngrams: proteaset!interceding-token ngrams: HAUSP )t!interceding-token ngrams: , HDAC1t7e1: ents2Label-mention-ngram: physically interacts witht(interceding-token ngrams: containing PHDt>e1: trigger-arg-path: Binding >prep_with [lemma='tip60'] themet'interceding-token ngrams: ) , ubiquitint(interceding-token ngrams: on chromatin .t#interceding-token ngrams: 1 ( UHRF1t>e1: ents2Label-mention-ngram: interacts with acetyltransferaset7e1: args2Role-mention-ngram: THEME physically interactst$interceding-token ngrams: containingt5e2: ents2Label-mention-ngram: promotes acetylation oft9e1: args2Role-mention-ngram: with acetyltransferase THEMEt%interceding-token ngrams: , HDAC1 andt9e2: ents2Label-mention-ngram: SHARED promotes acetylationt#interceding-token ngrams: domains 1tDe1: trigger-arg-path: interacts:Binding >nsubj [lemma='dnmt1'] themetJe2: trigger-arg-path: promotes >nsubj [lemma='tip60'] Gene_or_gene_productt3e1: args2Role-mention-ngram: with acetyltransferaset*interceding-token ngrams: finger domains 1tinterceding-token ngrams: HAUSPt2interceding-token ngrams: , herpesvirus associatedt(e1: ents2Label-mention-ngram: physicallyt\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='dnmt1'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_with [lemma='tip60'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tip60'] controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: with acetyltransferasetMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='dnmt1'] themet[e2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tip60'] Gene_or_gene_productt(interceding-token ngrams: ubiquitin liket@e1: trigger-arg-path: interacts >prep_with [lemma='tip60'] themethe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tip60'] Gene_or_gene_productt#interceding-token ngrams: ) , HDAC1t+interceding-token ngrams: specific proteaset:interceding-token ngrams: herpesvirus associated ubiquitint*interceding-token ngrams: , ubiquitin liket-interceding-token ngrams: specific protease (tie2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='tip60'] controller:Gene_or_gene_productt!interceding-token ngrams: PHD andt-e1: args2Role-mention-ngram: THEME physicallytde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='dnmt1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tip60'] Gene_or_gene_productt%interceding-token ngrams: , ubiquitint#interceding-token ngrams: HDAC1 andtSe1: trigger-arg-path: interacts:Binding >nsubj [lemma='dnmt1'] Gene_or_gene_productt1e1: args2Role-mention-ngram: physically interactst)interceding-token ngrams: like containingt#interceding-token ngrams: ( UHRF1 )t'e1: args2Role-mention-ngram: physicallyt&interceding-token ngrams: on chromatintWe1: trigger-arg-path: interacts:Binding >prep_with [lemma='tip60'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tip60'] theme:Gene_or_gene_productt;e1: ents2Label-mention-ngram: with acetyltransferase SHAREDt)interceding-token ngrams: and RING fingertUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='tip60'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='dnmt1'] themetQe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tip60'] themetNe2: trigger-arg-path: promotes:Positive_regulation >nsubj Gene_or_gene_productt#interceding-token ngrams: UHRF1 ) ,t#interceding-token ngrams: HAUSP ) ,tTe2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='tip60'] controllert*interceding-token ngrams: protease ( HAUSPtnsubj [lemma='dnmt1'] themet6e1: args2Role-mention-ngram: physically interacts withtHe1: trigger-arg-path: interacts:Binding >prep_with [lemma='tip60'] themet#interceding-token ngrams: ( HAUSP )t+interceding-token ngrams: PCNA on chromatint interceding-token ngrams: fingert!interceding-token ngrams: PCNA ont3interceding-token ngrams: ubiquitin like containingtbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='dnmt1'] theme:Gene_or_gene_productt@e2: trigger-arg-path: promotes >nsubj [lemma='tip60'] controllertee2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='tip60'] controllert7interceding-token ngrams: associated ubiquitin specifict^e2: trigger-arg-path: promotes:Positive_regulation >nsubj [lemma='tip60'] Gene_or_gene_producttUe1: trigger-arg-path: interacts >prep_with [lemma='tip60'] theme:Gene_or_gene_producttYe1: trigger-arg-path: interacts:Binding >nsubj [lemma='dnmt1'] theme:Gene_or_gene_productt-interceding-token ngrams: like containing PHDt(interceding-token ngrams: finger domainst?interceding-tokens-full-span: , herpesvirus associated ubiquitin specific protease ( HAUSP ) , ubiquitin like containing PHD and RING finger domains 1 ( UHRF1 ) , HDAC1 and PCNA on chromatin .tMe1: trigger-arg-path: Binding >prep_with [lemma='tip60'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='tip60'] controllertoe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='tip60'] Gene_or_gene_productt`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='tip60'] controller:Gene_or_gene_productt%interceding-token ngrams: herpesvirustQe1: trigger-arg-path: interacts >nsubj [lemma='dnmt1'] theme:Gene_or_gene_productt,interceding-token ngrams: containing PHD andt4e1: args2Role-mention-ngram: acetyltransferase THEMEt(interceding-token ngrams: HDAC1 and PCNAtIe1: trigger-arg-path: Binding >nsubj [lemma='dnmt1'] Gene_or_gene_productt]e1: trigger-arg-path: interacts:Binding >prep_with [lemma='tip60'] theme:Gene_or_gene_productt9e1: ents2Label-mention-ngram: SHARED physically interactst%interceding-token ngrams: and PCNA ont2e2: ents2Label-mention-ngram: promotes acetylationtUe2: trigger-arg-path: promotes >nsubj [lemma='tip60'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='dnmt1'] theme:Gene_or_gene_productt-interceding-token ngrams: RING finger domainst!interceding-token ngrams: UHRF1 )t6e1: ents2Label-mention-ngram: acetyltransferase SHAREDt&interceding-token ngrams: PHD and RINGtOe1: trigger-arg-path: interacts >prep_with [lemma='tip60'] Gene_or_gene_producttinterceding-token ngrams: Rightt(interceding-token ngrams: of NF-kappaB .t,interceding-token ngrams: interaction ; thist(interceding-token ngrams: p50 and PARP-1t#interceding-token ngrams: ( Right )t#interceding-token ngrams: . ( Rightt'interceding-token ngrams: NF-kappaB . (t!anaphor-basic: trigger: formationt0interceding-token ngrams: detection promotes thet+interceding-token ngrams: ; this ultimatelyt*interceding-token ngrams: to activation oft)interceding-token ngrams: this ultimatelyt!interceding-token ngrams: p50 andt2anaphor-basic: ents2Label-mention-ngram: formationt.interceding-token ngrams: p50-p300 interactiont%interceding-token ngrams: between p50t$interceding-token ngrams: and PARP-1t(interceding-token ngrams: PARP-1 as wellt-interceding-token ngrams: leads to activationt interceding-token ngrams: PARP-1t"interceding-token ngrams: p50-p300t'interceding-token ngrams: and PARP-1 ast(CSSPATH: ROOT >dobj ++ ROOT >csubj >dobjt/interceding-token ngrams: this ultimately leadst3interceding-token ngrams: damage detection promotest2interceding-token ngrams: the p50-p300 interactiont1interceding-token ngrams: the interaction betweent?interceding-tokens-full-span: , enhancing the interaction between p50 and PARP-1 as well as the p50-p300 interaction ; this ultimately leads to activation of NF-kappaB . ( Right ) DNA damage detection promotes thet)interceding-token ngrams: as the p50-p300t!interceding-token ngrams: Right )t!interceding-token ngrams: ( Rightt'interceding-token ngrams: interaction ;t&interceding-token ngrams: ) DNA damaget*interceding-token ngrams: ultimately leadst%interceding-token ngrams: NF-kappaB .t$interceding-token ngrams: ultimatelyt0interceding-token ngrams: p50-p300 interaction ;t&interceding-token ngrams: the p50-p300t%interceding-token ngrams: Right ) DNAtAe1: ents2Label-mention-ngram: acetylation of GENE_OR_GENE_PRODUCTtinterceding-token ngrams: ) DNAt'interceding-token ngrams: to activationt,interceding-token ngrams: detection promotest3interceding-token ngrams: enhancing the interactiont1interceding-token ngrams: activation of NF-kappaBt-interceding-token ngrams: interaction betweent#interceding-token ngrams: PARP-1 ast&interceding-token ngrams: of NF-kappaBt*interceding-token ngrams: damage detectiontinterceding-token ngrams: p50t)interceding-token ngrams: between p50 andt#interceding-token ngrams: detectiont1anaphor-basic: args2Role-mention-ngram: formationt.interceding-token ngrams: DNA damage detectiont-interceding-token ngrams: ultimately leads tot1interceding-token ngrams: interaction between p50tce2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: protein specifically bindst[e2: trigger-arg-path: binds >nsubj [lemma='protein'] >nn [lemma='p53'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='p53'] themetinterceding-token ngrams: ChIPtRe1: trigger-arg-path: binding:Binding >nn [lemma='p53'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_to [lemma='promoter'] themet#interceding-token ngrams: confirmedt2e2: args2Role-mention-ngram: specifically binds tot5e1: trigger-arg-path: binding >nn [lemma='p53'] themet8CSSPATH: ROOT >nsubj >prep >pobj >prep_of ++ ROOT >ccompt=e1: trigger-arg-path: binding:Binding >nn [lemma='p53'] themetOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] themet'interceding-token ngrams: the RASSF1A .tle2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='p53'] Gene_or_gene_productt7e2: args2Role-mention-ngram: protein specifically bindstVe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] Gene_or_gene_producttie2: trigger-arg-path: binds:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] theme:Gene_or_gene_productt\e1: trigger-arg-path: binding:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt#interceding-token ngrams: Chromatint?interceding-tokens-full-span: using Chromatin Immunoprecipitation ( ChIP ) assay confirmed p53 binding to the RASSF1A . These results indicated that thetJe1: trigger-arg-path: binding >nn [lemma='p53'] theme:Gene_or_gene_productt0interceding-token ngrams: results indicated thatt'interceding-token ngrams: confirmed p53the1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='promoter'] Gene_or_gene_producttLe1: trigger-arg-path: binding:Binding >nn [lemma='p53'] Gene_or_gene_productt9interceding-token ngrams: Chromatin Immunoprecipitation (t interceding-token ngrams: ( ChIPt7e2: args2Role-mention-ngram: THEME protein specificallytEe2: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] themetVe1: trigger-arg-path: binding:Binding >prep_to [lemma='promoter'] Gene_or_gene_productt(interceding-token ngrams: to the RASSF1At interceding-token ngrams: ChIP )tNe2: trigger-arg-path: Binding >prep_to [lemma='promoter'] Gene_or_gene_producttce2: trigger-arg-path: binds:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: SHARED protein specificallyt)interceding-token ngrams: using Chromatint/interceding-token ngrams: Immunoprecipitation (tNe2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='p53'] themetee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] themet`e1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='promoter'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='promoter'] themet7interceding-token ngrams: Chromatin Immunoprecipitationt^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] Gene_or_gene_producttZe2: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: specifically binds tot]e2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='p53'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p53'] theme:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] >nn [lemma='p53'] theme:Gene_or_gene_productt/interceding-token ngrams: confirmed p53 bindingtTe2: trigger-arg-path: Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] themet+interceding-token ngrams: results indicatedtNe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='promoter'] themet+interceding-token ngrams: ) assay confirmedt?e1: trigger-arg-path: binding >prep_to [lemma='promoter'] themet5e1: trigger-arg-path: Binding >nn [lemma='p53'] themet4interceding-token ngrams: Immunoprecipitation ( ChIPtTe1: trigger-arg-path: binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: SHARED proteintLe2: trigger-arg-path: binds >prep_to [lemma='promoter'] Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME proteintTe2: trigger-arg-path: binds:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] themet/e2: args2Role-mention-ngram: specifically bindst#interceding-token ngrams: RASSF1A .t=e2: trigger-arg-path: binds >prep_to [lemma='promoter'] themetLe2: trigger-arg-path: binds >nsubj [lemma='protein'] >nn [lemma='p53'] themetDe1: trigger-arg-path: binding >nn [lemma='p53'] Gene_or_gene_productt1e2: args2Role-mention-ngram: protein specificallyt0e2: ents2Label-mention-ngram: specifically bindstJe1: trigger-arg-path: Binding >nn [lemma='p53'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binding:Binding >prep_to [lemma='promoter'] themette2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] >nn [lemma='p53'] Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >prep_to [lemma='promoter'] Gene_or_gene_productt!interceding-token ngrams: ) assayt&interceding-token ngrams: ChIP ) assayt"interceding-token ngrams: ( ChIP )tae2: trigger-arg-path: binds >nsubj [lemma='protein'] >nn [lemma='p53'] theme:Gene_or_gene_productt-interceding-token ngrams: assay confirmed p53tQe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='promoter'] themetke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt(interceding-token ngrams: binding to thet-interceding-token ngrams: Immunoprecipitationtne1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='promoter'] theme:Gene_or_gene_productt)interceding-token ngrams: RASSF1A . Theset\e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binds >prep_to [lemma='promoter'] theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p53'] themet2e2: ents2Label-mention-ngram: protein specificallytDe1: trigger-arg-path: Binding >nn [lemma='p53'] Gene_or_gene_producttce2: trigger-arg-path: Binding >nsubj [lemma='protein'] >nn [lemma='p53'] theme:Gene_or_gene_productt%interceding-token ngrams: the RASSF1At=interceding-token ngrams: using Chromatin Immunoprecipitationt1interceding-token ngrams: These results indicatedt)interceding-token ngrams: assay confirmedtNe1: trigger-arg-path: binding >prep_to [lemma='promoter'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: restricts:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt{e2: trigger-arg-path: Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlledtee2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj [lemma='p53'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Negative_activation >nsubj [lemma='p53'] controller:Gene_or_gene_productt)e2: ents2Label-mention-ngram: Ras inducedt?e2: trigger-arg-path: restricts >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt;e2: trigger-arg-path: restricts >ccomp >dobj >nn controlledtSe2: trigger-arg-path: restricts:Negative_activation >nsubj [lemma='p53'] controllertne2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj [lemma='p53'] Gene_or_gene_producttOe2: trigger-arg-path: restricts:Negative_activation >ccomp >dobj >nn controlledt1e2: trigger-arg-path: restricts >nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlledtEe2: trigger-arg-path: restricts:Negative_activation >nsubj controllert?e2: trigger-arg-path: Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_productt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT restricts Rast(e2: args2Role-mention-ngram: Ras inducedt?e2: trigger-arg-path: restricts >nsubj [lemma='p53'] controllertFe2: trigger-arg-path: restricts >nsubj controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: CONTROLLER restrictst`e2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp >dobj >nn controlledtZe2: trigger-arg-path: Negative_activation >ccomp >dobj >nn controlled:Gene_or_gene_producttPe2: trigger-arg-path: restricts >ccomp >dobj >nn controlled:Gene_or_gene_productt]e2: trigger-arg-path: restricts:Negative_activation >nsubj [lemma='p53'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: restricts Ras inducedtue2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp >dobj >nn controlled:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp >dobj >nn controlledt{e2: trigger-arg-path: restricts >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_producttTe2: trigger-arg-path: restricts >nsubj [lemma='p53'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Negative_activation >nsubj [lemma='p53'] controllert?e2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_producttSe2: trigger-arg-path: Negative_activation >nsubj [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj [lemma='p53'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp >dobj >nn Gene_or_gene_producttEe2: trigger-arg-path: Negative_activation >ccomp >dobj >nn controlledt&e2: args2Role-mention-ngram: restrictst*e2: args2Role-mention-ngram: restricts Rast;e2: trigger-arg-path: restricts >nsubj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlledtqe2: trigger-arg-path: restricts >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlledt5e2: args2Role-mention-ngram: CONTROLLER restricts Rast'e2: ents2Label-mention-ngram: restrictste2: trigger: restrictstVe2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj controllert.e2: ents2Label-mention-ngram: Ras induced celltOe2: trigger-arg-path: restricts:Negative_activation >nsubj Gene_or_gene_productt?interceding-tokens-full-span: and Omi in mitochondria and decreased the invasion of Ras transformed p53 -/ - MEFs . Altogether , these results suggest that cytoplasmictZe2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj [lemma='p53'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp >dobj >nn Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj [lemma='p53'] controllertIe2: trigger-arg-path: restricts >nsubj [lemma='p53'] Gene_or_gene_producttYe2: trigger-arg-path: restricts:Negative_activation >ccomp >dobj >nn Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj controllert+e2: ents2Label-mention-ngram: restricts RastZe2: trigger-arg-path: restricts:Negative_activation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: restricts:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt-e2: args2Role-mention-ngram: Ras induced cellt2e2: args2Role-mention-ngram: restricts Ras inducedtOe2: trigger-arg-path: Negative_activation >ccomp >dobj >nn Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=restrict >ccomp >dobj >nn controlled:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj Gene_or_gene_producttnsubj [lemma='p53'] controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_producttde2: trigger-arg-path: restricts:Negative_activation >ccomp >dobj >nn controlled:Gene_or_gene_producttEe2: trigger-arg-path: restricts >ccomp >dobj >nn Gene_or_gene_productt?e2: trigger-arg-path: Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: restricts:Negative_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='htra2'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=restrict:Negative_activation >nsubj [lemma='p53'] controllertLe2: trigger-arg-path: lemmatizedTrigger=restrict >nsubj Gene_or_gene_producttAe2: trigger-arg-path: induces >dobj >prep_of Gene_or_gene_productt0e2: args2Role-mention-ngram: complex induces thet7e2: args2Role-mention-ngram: CONTROLLER complex inducest^e1: trigger-arg-path: phosphorylate >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: the degradationt"interceding-token ngrams: Axin andtye2: trigger-arg-path: induces >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlled:Gene_or_gene_producttOe1: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] controllertIe1: trigger-arg-path: phosphorylate >nsubj [lemma='GSK-3beta'] controllert&interceding-token ngrams: The Axin andtinterceding-token ngrams: S37tpe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: phosphorylate SHARED ont?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlledtge1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttLe2: trigger-arg-path: induces >dobj >prep_of controlled:Gene_or_gene_productt,e2: args2Role-mention-ngram: the degradationtde1: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttinterceding-token ngrams: -3 /t`e2: trigger-arg-path: induces:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >prep_of controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlled:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: can then phosphorylatet!interceding-token ngrams: S37 andt0e1: args2Role-mention-ngram: can then CONTROLLEDt$interceding-token ngrams: . The Axintinterceding-token ngrams: T41tCSSPATH: ROOT  ++ ROOT >deptinterceding-token ngrams: -3t%e1: args2Role-mention-ngram: can thent?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlled:Gene_or_gene_producttinterceding-token ngrams: T41 .t0e1: args2Role-mention-ngram: CONTROLLER can thent7e1: ents2Label-mention-ngram: then phosphorylate SHAREDtue2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlledtde2: trigger-arg-path: induces >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlledt#interceding-token ngrams: , S37 andt-e2: ents2Label-mention-ngram: complex inducest$interceding-token ngrams: and GSK -3tinterceding-token ngrams: , S37t?e2: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlled:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='GSK-3beta'] controllert;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can thent interceding-token ngrams: GSK -3t0e1: ents2Label-mention-ngram: then phosphorylatet!interceding-token ngrams: and T41tKe2: trigger-arg-path: induces:Negative_activation >dobj >prep_of controlledtqe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >prep_of controlled:Gene_or_gene_producttre1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: can thent,e2: args2Role-mention-ngram: complex inducest+e1: ents2Label-mention-ngram: SHARED on S33t#interceding-token ngrams: and T41 .t?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] Gene_or_gene_productt%interceding-token ngrams: S37 and T41t4e2: args2Role-mention-ngram: induces the degradationtfe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >prep_of Gene_or_gene_productt1e2: ents2Label-mention-ngram: complex induces thet!e1: ents2Label-mention-ngram: S33t?e2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] Gene_or_gene_producttSe1: trigger-arg-path: phosphorylate >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttCinterceding-tokens-full-span: , S37 and T41 . The Axin and GSK -3 /tee1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='GSK-3beta'] Gene_or_gene_productt?e2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlled:Gene_or_gene_productt7e2: trigger-arg-path: induces >dobj >prep_of controlledt&interceding-token ngrams: Axin and GSKt0e2: ents2Label-mention-ngram: the degradation oft"interceding-token ngrams: GSK -3 /toe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] controllert$e1: ents2Label-mention-ngram: on S33tBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT complex inducestinterceding-token ngrams: GSKtinterceding-token ngrams: Axint]e1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] controllertxe2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlledt/e2: args2Role-mention-ngram: the degradation oft!interceding-token ngrams: and GSKt"interceding-token ngrams: The Axint#interceding-token ngrams: T41 . Thetze2: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: induces the degradationtUe2: trigger-arg-path: induces:Negative_activation >dobj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttYe1: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttne2: trigger-arg-path: induces >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] Gene_or_gene_producttpe2: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >prep_of [lemma='beta-catenin'] controlledt^e1: trigger-arg-path: bound >nsubj [lemma='level'] >prep_of [lemma='gtp'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj >prep_of controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] Complext?e2: trigger-arg-path: increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controllertme2: trigger-arg-path: increase nsubj [lemma='level'] >prep_of [lemma='gtp'] controllert.e2: args2Role-mention-ngram: also increase andt`e1: trigger-arg-path: Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] Gene_or_gene_producttTe1: trigger-arg-path: bound:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] Familytue2: trigger-arg-path: Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] Complext)e2: ents2Label-mention-ngram: and lead tot@e2: trigger-arg-path: lemmatizedTrigger=increase >prep_to Familyt&e2: ents2Label-mention-ngram: and leadtOe2: trigger-arg-path: increase:Positive_activation >prep_to [lemma='ra'] FamilytKe1: trigger-arg-path: bound >ccomp [lemma='lead'] >nsubj [lemma='ra'] themetae2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to [lemma='ra'] FamilytQe2: trigger-arg-path: Positive_activation >prep_to [lemma='ra'] controlled:Familyt.e2: args2Role-mention-ngram: can also increaset?e2: trigger-arg-path: increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controller:Complext/e2: args2Role-mention-ngram: lead to CONTROLLEDtKe2: trigger-arg-path: Positive_activation nsubj >prep_of controllert%e2: ents2Label-mention-ngram: lead tot(e2: args2Role-mention-ngram: and lead totSe2: trigger-arg-path: increase:Positive_activation >prep_to [lemma='ra'] controlledtee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] FamilytMe2: trigger-arg-path: increase:Positive_activation >prep_to controlled:Familyt\e2: trigger-arg-path: increase:Positive_activation nsubj >prep_of controller:Complext/e2: ents2Label-mention-ngram: also increase andt/e2: ents2Label-mention-ngram: can also increasetue1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='level'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to [lemma='ra'] controlledtTe1: trigger-arg-path: Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] theme:FamilytXe2: trigger-arg-path: lemmatizedTrigger=increase >prep_to [lemma='ra'] controlled:Familytue2: trigger-arg-path: increase nsubj [lemma='level'] >prep_of [lemma='gtp'] controller:Complext/e2: ents2Label-mention-ngram: increase and leadtTe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to Familyt\e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='lead'] >nsubj [lemma='ra'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='lead'] >nsubj [lemma='ra'] Familyt,e2: ents2Label-mention-ngram: lead to SHAREDt=e2: trigger-arg-path: increase nsubj >prep_of Complextoe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='level'] >prep_of [lemma='gtp'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=increase >prep_to controlled:FamilytHe2: trigger-arg-path: increase nsubj >prep_of controller:ComplextOe2: trigger-arg-path: lemmatizedTrigger=increase nsubj >prep_of Complext9e2: trigger-arg-path: Positive_activation >prep_to Familyt`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='level'] >prep_of [lemma='gtp'] themetMe2: trigger-arg-path: lemmatizedTrigger=increase >prep_to [lemma='ra'] Familytne2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj >prep_of controller:Complextle1: trigger-arg-path: bound:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttxe2: trigger-arg-path: Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controllertDe2: trigger-arg-path: Positive_activation >prep_to controlled:Familyt|e2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='level'] >prep_of [lemma='gtp'] ComplextMe1: trigger-arg-path: Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] themetOe1: trigger-arg-path: bound >nsubj [lemma='level'] >prep_of [lemma='gtp'] themetctrigger-to-trigger-path: e1:bound:Binding >ccomp [lemma='increase'] e2:increase:Positive_activationtde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] themetLe1: trigger-arg-path: bound >ccomp [lemma='lead'] >nsubj [lemma='ra'] Familyt?e2: trigger-arg-path: Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controller:Complext}e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt;e2: trigger-arg-path: increase >prep_to [lemma='ra'] Familytfe1: trigger-arg-path: bound:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] Gene_or_gene_productt=e2: trigger-arg-path: Positive_activation >prep_to controlledt~e2: trigger-arg-path: increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] Complext*e2: ents2Label-mention-ngram: increase andt$e2: args2Role-mention-ngram: lead totle2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to [lemma='ra'] controlled:Familytce1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='lead'] >nsubj [lemma='ra'] theme:Familyt.e2: ents2Label-mention-ngram: bound SHARED cantke1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] theme:FamilytSe2: trigger-arg-path: Positive_activation nsubj >prep_of controller:Complext?e2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='level'] >prep_of [lemma='gtp'] controller:ComplextZe2: trigger-arg-path: lemmatizedTrigger=increase nsubj >prep_of controller:Complext!e2: args2Role-mention-ngram: leadtFe2: trigger-arg-path: increase >prep_to [lemma='ra'] controlled:FamilytPtrigger-to-trigger-path: e1:bound:Binding >ccomp e2:increase:Positive_activationt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controller:Complextce2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj >prep_of ComplextBe2: trigger-arg-path: increase:Positive_activation >prep_to FamilytRe1: trigger-arg-path: bound >ccomp [lemma='lead'] >nsubj [lemma='ra'] theme:FamilytSe1: trigger-arg-path: bound:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] themet_e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to controlled:FamilytXe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >prep_to controlledtNe1: trigger-arg-path: Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] Familytwe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] Gene_or_gene_producttTe2: trigger-arg-path: increase:Positive_activation nsubj >prep_of controllertFe2: trigger-arg-path: Positive_activation >prep_to [lemma='ra'] FamilytWe1: trigger-arg-path: bound:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] themetQe2: trigger-arg-path: lemmatizedTrigger=increase >prep_to [lemma='ra'] controlledtRe2: trigger-arg-path: lemmatizedTrigger=increase nsubj >prep_of controllertQe2: trigger-arg-path: increase:Positive_activation nsubj >prep_of Complexte2: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='level'] >prep_of [lemma='gtp'] controllertHe2: trigger-arg-path: Positive_activation nsubj >prep_of Complext*e2: args2Role-mention-ngram: also increaset9e2: trigger-arg-path: increase >prep_to controlled:FamilytJe2: trigger-arg-path: Positive_activation >prep_to [lemma='ra'] controlledtde1: trigger-arg-path: bound >nsubj [lemma='level'] >prep_of [lemma='gtp'] theme:Gene_or_gene_producttFe2: trigger-arg-path: increase:Positive_activation >prep_to controlledt2e2: trigger-arg-path: increase >prep_to controlledtZe2: trigger-arg-path: increase:Positive_activation >prep_to [lemma='ra'] controlled:FamilytDe2: trigger-arg-path: lemmatizedTrigger=increase >prep_to controlledtje2: trigger-arg-path: increase nsubj [lemma='level'] >prep_of [lemma='gtp'] Complext@e2: trigger-arg-path: increase nsubj >prep_of controllerthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] themet?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation nsubj [lemma='level'] >prep_of [lemma='gtp'] controllert%e2: args2Role-mention-ngram: and leadt=shortest-path: prep_to [lemma='ra'] controlledtZe1: trigger-arg-path: bound:Binding >ccomp [lemma='lead'] >nsubj [lemma='ra'] theme:Familyt)e2: args2Role-mention-ngram: increase andt"e2: ents2Label-mention-ngram: leadt+e2: ents2Label-mention-ngram: also increasetfe1: trigger-arg-path: Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] theme:Gene_or_gene_productt.e2: trigger-arg-path: increase >prep_to FamilytQe1: trigger-arg-path: Binding >nsubj [lemma='level'] >prep_of [lemma='gtp'] themet-interceding-token ngrams: activating residuest+interceding-token ngrams: ) . Interestinglyt0interceding-token ngrams: phosphorylation statust+interceding-token ngrams: of the activatingtOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='erk'] themet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mkp3'] theme:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='mkp3'] themetNe1: trigger-arg-path: Binding >nsubj [lemma='mkp3'] theme:Gene_or_gene_productt[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] theme:Gene_or_gene_productt!interceding-token ngrams: ( KIM )t-interceding-token ngrams: dissociation of thet!interceding-token ngrams: KIM ) .t,interceding-token ngrams: as phosphorylationtTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mkp3'] themet+interceding-token ngrams: a dissociation oft interceding-token ngrams: statust,CSSPATH: ROOT  ++ ROOT >advcl >dobj >prep_oft+interceding-token ngrams: interaction motiftSe1: trigger-arg-path: interacts >prep_with [lemma='erk'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mkp3'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] themetPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mkp3'] themetDe2: trigger-arg-path: complex >nn [lemma='erk'] Gene_or_gene_productt4interceding-token ngrams: interaction is independentt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='mkp3'] themet3interceding-token ngrams: phosphatase termed kinasetle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='erk'] theme:Gene_or_gene_productt%interceding-token ngrams: a region oftEe2: trigger-arg-path: complex >nn [lemma='mkp3'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mkp3'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='erk'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mkp3'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='mkp3'] themet'interceding-token ngrams: status of ERKt(interceding-token ngrams: is independenttee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mkp3'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='mkp3'] Gene_or_gene_productt>e1: trigger-arg-path: interacts >prep_with [lemma='erk'] themet%interceding-token ngrams: residues oftie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mkp3'] theme:Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='erk'] themet"interceding-token ngrams: ERK doestae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] theme:Gene_or_gene_productt.interceding-token ngrams: Interestingly , thist)interceding-token ngrams: the phosphatasetDe2: trigger-arg-path: Binding >nn [lemma='erk'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >nn [lemma='mkp3'] Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='erk'] themetSe2: trigger-arg-path: complex:Binding >nn [lemma='mkp3'] theme:Gene_or_gene_producttinterceding-token ngrams: KIMt&interceding-token ngrams: not induce at%interceding-token ngrams: ERK and itst,interceding-token ngrams: independent of thet'interceding-token ngrams: activity , astUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] Gene_or_gene_productt(interceding-token ngrams: a dissociationt5e2: trigger-arg-path: complex >nn [lemma='erk'] themet3interceding-token ngrams: phosphorylation status oft+interceding-token ngrams: is independent oft0interceding-token ngrams: activating residues oft%interceding-token ngrams: of ERK doestKe2: trigger-arg-path: complex >nn [lemma='mkp3'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='mkp3'] theme:Gene_or_gene_producttLe2: trigger-arg-path: complex:Binding >nn [lemma='erk'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='erk'] theme:Gene_or_gene_producttinterceding-token ngrams: KIM )t\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='erk'] theme:Gene_or_gene_productt!interceding-token ngrams: motif (t3interceding-token ngrams: termed kinase interactiont2interceding-token ngrams: kinase interaction motiftOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] themet"interceding-token ngrams: induce at/interceding-token ngrams: as phosphorylation oftJe2: trigger-arg-path: Binding >nn [lemma='erk'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_with [lemma='erk'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='erk'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='mkp3'] Gene_or_gene_productt5interceding-tokens-full-span: through a region of the phosphatase termed kinase interaction motif ( KIM ) . Interestingly , this interaction is independent of the phosphorylation status of ERK and its kinase activity , as phosphorylation of the activating residues of ERK does not induce a dissociation of thet'interceding-token ngrams: termed kinaset0interceding-token ngrams: the phosphatase termedt,interceding-token ngrams: of the phosphataset)interceding-token ngrams: does not inducetCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mkp3'] themet(interceding-token ngrams: and its kinaset4interceding-token ngrams: the phosphorylation statust9e1: trigger-arg-path: Binding >nsubj [lemma='mkp3'] themet,interceding-token ngrams: , this interactiontinterceding-token ngrams: ( KIMt0interceding-token ngrams: of the phosphorylationt*interceding-token ngrams: through a regiont&interceding-token ngrams: ERK does nott-interceding-token ngrams: interaction motif (tprep_with [lemma='erk'] themetHe1: trigger-arg-path: Binding >nsubj [lemma='mkp3'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='erk'] themet^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='erk'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] themetHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mkp3'] themet(interceding-token ngrams: the activatingtJe2: trigger-arg-path: complex >nn [lemma='erk'] theme:Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_with [lemma='erk'] theme:Gene_or_gene_producttinterceding-token ngrams: motiftPe1: trigger-arg-path: interacts >nsubj [lemma='mkp3'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='mkp3'] Gene_or_gene_producttRe2: trigger-arg-path: complex:Binding >nn [lemma='erk'] theme:Gene_or_gene_productt#interceding-token ngrams: status oft interceding-token ngrams: termedtMe2: trigger-arg-path: complex:Binding >nn [lemma='mkp3'] Gene_or_gene_productt.interceding-token ngrams: , as phosphorylationt6e2: trigger-arg-path: Binding >nn [lemma='mkp3'] themet^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] Gene_or_gene_producttMe1: trigger-arg-path: interacts >prep_with [lemma='erk'] Gene_or_gene_productt1interceding-token ngrams: the activating residuest,interceding-token ngrams: kinase interactiont/interceding-token ngrams: induce a dissociationt)interceding-token ngrams: residues of ERKt=e2: trigger-arg-path: complex:Binding >nn [lemma='erk'] themet,interceding-token ngrams: phosphatase termedt!interceding-token ngrams: and itst%interceding-token ngrams: motif ( KIMt?e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] Sitet`e2: trigger-arg-path: Positive_regulation >nsubj [lemma='erbb2'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='erbb2'] controllert=e1: ents2Label-mention-ngram: Binding of GENE_OR_GENE_PRODUCTt0interceding-token ngrams: in the phosphorylationtEe1: trigger-arg-path: lemmatizedTrigger=binding dobj >nn sitet"interceding-token ngrams: of ErbB2tee2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='erbb2'] controllertre1: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] site:Sitet+interceding-token ngrams: ErbB2 , resultingt2e1: ents2Label-mention-ngram: to SHARED stimulatest0e1: args2Role-mention-ngram: to THEME stimulatest(interceding-token ngrams: both receptorst;e1: trigger-arg-path: Binding:Binding dobj >nn sitet4e1: ents2Label-mention-ngram: the intrinsic tyrosinet,e1: ents2Label-mention-ngram: stimulates thetJe2: trigger-arg-path: mediated >nsubj [lemma='erbb2'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: intrinsic tyrosinet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=binding dobj >nn site:SitetRe1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj >nn site:Sitet3e1: ents2Label-mention-ngram: SHARED stimulates thet*interceding-token ngrams: both receptors .tme1: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] Sitetqe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] Gene_or_gene_producttoe1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] theme:Gene_or_gene_producttZe1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] themet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] Gene_or_gene_productt!interceding-token ngrams: ErbB2 ,tEe1: trigger-arg-path: lemmatizedTrigger=binding dobj >nn Sitet@e2: trigger-arg-path: mediated >nsubj [lemma='erbb2'] controllert6e1: ents2Label-mention-ngram: stimulates the intrinsict+interceding-token ngrams: of both receptorst;e1: trigger-arg-path: Binding:Binding dobj >nn Sitet@e1: trigger-arg-path: Binding:Binding dobj >nn site:Sitet/e1: ents2Label-mention-ngram: SHARED stimulatestLe1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding dobj [lemma='activity'] >nn [lemma='tyrosine'] site:SitetWe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] themetOe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] themetue1: trigger-arg-path: Binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] sitet!interceding-token ngrams: of botht+interceding-token ngrams: activity of ErbB2t8e1: trigger-arg-path: Binding dobj >nn site:Sitet5e1: args2Role-mention-ngram: stimulates the intrinsictde1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=binding dobj [lemma='activity'] >nn [lemma='tyrosine'] sitetinterceding-token ngrams: ErbB2tze2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='erbb2'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='erbb2'] Gene_or_gene_producttTe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] Gene_or_gene_producttue1: trigger-arg-path: Binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] Sitetle1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj >nn sitetEe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] themetTe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='erbb2'] controllert3e1: trigger-arg-path: Binding dobj >nn sitetwe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] theme:Gene_or_gene_productt1interceding-token ngrams: phosphorylation of botht$interceding-token ngrams: of ErbB2 ,t1e1: args2Role-mention-ngram: THEME stimulates thetUe2: trigger-arg-path: mediated >nsubj [lemma='erbb2'] controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] themet^e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='erbb2'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='erbb2'] Gene_or_gene_producttze1: trigger-arg-path: Binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] site:Sitetminterceding-tokens-full-span: kinase activity of ErbB2 , resulting in the phosphorylation of both receptors .t-e1: args2Role-mention-ngram: THEME stimulatestie2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='erbb2'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: stimulates thet?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] sitet{e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj >nn Sitetbe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] themetie1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] Gene_or_gene_productt3e1: trigger-arg-path: Binding dobj >nn SitetRe1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_of [lemma='sema4d'] themet+e1: args2Role-mention-ngram: intrinsic SITEtfe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='erbb2'] controller:Gene_or_gene_productt,interceding-token ngrams: kinase activity oftKe2: trigger-arg-path: Positive_regulation >nsubj [lemma='erbb2'] controllertme1: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] sitetUe2: trigger-arg-path: Positive_regulation >nsubj [lemma='erbb2'] Gene_or_gene_producttZe1: trigger-arg-path: Binding:Binding >prep_of [lemma='sema4d'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=binding dobj [lemma='activity'] >nn [lemma='tyrosine'] Sitette1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='sema4d'] >prep_to [lemma='plexin-b1'] themet^e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='sema4d'] Gene_or_gene_productt/e1: args2Role-mention-ngram: the intrinsic SITEt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding dobj [lemma='activity'] >nn [lemma='tyrosine'] site:Sitet6e1: ents2Label-mention-ngram: activation of endogenoustBe1: trigger-arg-path: block >nsubj controller:Gene_or_gene_productt/interceding-token ngrams: NAC treatment reducedt/e1: args2Role-mention-ngram: hypoxic activationt)interceding-token ngrams: . NAC treatmentt2e1: args2Role-mention-ngram: endogenous CONTROLLEDt0e1: ents2Label-mention-ngram: hypoxic activationtSe1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj controllertee1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >prep_of Gene_or_gene_producttSe1: trigger-arg-path: block:Negative_activation >dobj >prep_of Gene_or_gene_producttde1: trigger-arg-path: block:Negative_activation >nsubj [lemma='nac'] controller:Gene_or_gene_producttIe1: trigger-arg-path: Negative_activation >nsubj [lemma='nac'] controllerte1: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='src'] controlled:Gene_or_gene_productt2e1: args2Role-mention-ngram: hypoxic activation oft*e1: args2Role-mention-ngram: of endogenoust(e1: args2Role-mention-ngram: could blockt.e1: args2Role-mention-ngram: block the hypoxict-e1: args2Role-mention-ngram: CONTROLLER couldtpe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] Gene_or_gene_productt5e1: args2Role-mention-ngram: activation of endogenoust^e1: trigger-arg-path: Negative_activation >nsubj [lemma='nac'] controller:Gene_or_gene_producttbe1: trigger-arg-path: block >dobj [lemma='activation'] >prep_of [lemma='src'] Gene_or_gene_productt=e1: ents2Label-mention-ngram: endogenous GENE_OR_GENE_PRODUCTt]e1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj Gene_or_gene_producttIe1: trigger-arg-path: block:Negative_activation >dobj >prep_of controlledtSe1: trigger-arg-path: Negative_activation >nsubj [lemma='nac'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of Gene_or_gene_productt'interceding-token ngrams: NAC treatmentt.e2: ents2Label-mention-ngram: GTP bound FAMILYt*CSSPATH: ROOT >xcomp >ccomp ++ ROOT >ccompt-e1: ents2Label-mention-ngram: could block thet5e1: trigger-arg-path: block >dobj >prep_of controlledt5e1: args2Role-mention-ngram: of endogenous CONTROLLEDtYe1: trigger-arg-path: block:Negative_activation >nsubj [lemma='nac'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] Gene_or_gene_producttEe1: trigger-arg-path: block >nsubj [lemma='nac'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of controlledt{e1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlled:Gene_or_gene_producttme1: trigger-arg-path: block >dobj [lemma='activation'] >prep_of [lemma='src'] controlled:Gene_or_gene_producttAe1: trigger-arg-path: block:Negative_activation >nsubj controllert&e1: args2Role-mention-ngram: block thetMe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='nac'] controllertXe1: trigger-arg-path: block >dobj [lemma='activation'] >prep_of [lemma='src'] controlledtinterceding-token ngrams: . NACtWe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='nac'] Gene_or_gene_productt%interceding-token ngrams: reduced thetPe1: trigger-arg-path: block >nsubj [lemma='nac'] controller:Gene_or_gene_productt/interceding-token ngrams: reduced the inductiontke1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='nac'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='nac'] controllertve1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj [lemma='nac'] controller:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >nsubj controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj >prep_of controlledtinterceding-token ngrams: NACt-e1: trigger-arg-path: block >nsubj controllert/e1: ents2Label-mention-ngram: block the hypoxictOe1: trigger-arg-path: block:Negative_activation >nsubj [lemma='nac'] controllertVe1: trigger-arg-path: block:Negative_activation >nsubj controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: block thet?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=block >dobj >prep_of controlled:Gene_or_gene_productt3e1: args2Role-mention-ngram: CONTROLLER could blockt^e1: trigger-arg-path: block:Negative_activation >dobj >prep_of controlled:Gene_or_gene_productt;e1: trigger-arg-path: block >nsubj [lemma='nac'] controllert/interceding-token ngrams: treatment reduced thet~e1: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlledt7e1: trigger-arg-path: block >nsubj Gene_or_gene_productt$e1: args2Role-mention-ngram: hypoxicte1: trigger: blockt?e1: trigger-arg-path: block >dobj >prep_of Gene_or_gene_productt%e1: ents2Label-mention-ngram: hypoxict+e1: ents2Label-mention-ngram: of endogenoust)e1: ents2Label-mention-ngram: the hypoxictbe1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='nac'] controller:Gene_or_gene_productt@e1: ents2Label-mention-ngram: of endogenous GENE_OR_GENE_PRODUCTtKe1: trigger-arg-path: block:Negative_activation >nsubj Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=block >nsubj controller:Gene_or_gene_producttNinterceding-tokens-full-span: and Ras . NAC treatment reduced the induction oftje1: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='src'] controlledt#interceding-token ngrams: and Ras .t8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT couldtfe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlledtte1: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='activation'] >prep_of [lemma='src'] Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=block >nsubj Gene_or_gene_producttve1: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT could blocktle1: trigger-arg-path: block:Negative_activation >dobj [lemma='activation'] >prep_of [lemma='src'] controlledt#interceding-token ngrams: Ras . NACt3e1: args2Role-mention-ngram: the hypoxic activationt)e1: ents2Label-mention-ngram: could blockt+interceding-token ngrams: treatment reducedt"e1: args2Role-mention-ngram: couldtJe1: trigger-arg-path: block >dobj >prep_of controlled:Gene_or_gene_productt#e1: ents2Label-mention-ngram: couldt,e1: args2Role-mention-ngram: could block thet3e1: ents2Label-mention-ngram: hypoxic activation oft(e1: args2Role-mention-ngram: the hypoxict4e1: ents2Label-mention-ngram: the hypoxic activationt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlledt?e2: trigger-arg-path: increased:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] Gene_or_gene_productt,e2: args2Role-mention-ngram: dissociation oft'interceding-token ngrams: -2 and Beclint,interceding-token ngrams: between Bcl-xL andt interceding-token ngrams: Bcl-xLt)e2: ents2Label-mention-ngram: resulted int_e2: trigger-arg-path: increased >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controllert@e2: ents2Label-mention-ngram: and increased GENE_OR_GENE_PRODUCTt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlled:Gene_or_gene_productt9e2: ents2Label-mention-ngram: phosphorylation resulted int'e2: ents2Label-mention-ngram: 1 complextOe2: trigger-arg-path: Positive_activation >dobj >amod >dep Gene_or_gene_productt7e2: ents2Label-mention-ngram: increased dissociation oftpe2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controller:Familyt2e2: args2Role-mention-ngram: resulted in increasedt4e2: ents2Label-mention-ngram: Bcl-2-Beclin 1 complext~e2: trigger-arg-path: increased >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] Gene_or_gene_productt%e2: args2Role-mention-ngram: resultedt@e2: args2Role-mention-ngram: CONTROLLER phosphorylation resultedt4e2: ents2Label-mention-ngram: increased dissociationt7e2: ents2Label-mention-ngram: in increased dissociationt1e2: ents2Label-mention-ngram: dissociation of thet1e2: trigger-arg-path: increased >nsubj >nn Familyt)e2: args2Role-mention-ngram: dissociationtae2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn controller:Familyt2e2: args2Role-mention-ngram: complex and increasedt0e2: args2Role-mention-ngram: of the Bcl-2-BeclintPe2: trigger-arg-path: increased >dobj >amod >dep controlled:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >amod >dep Gene_or_gene_productt&interceding-token ngrams: and Beclin 1t&e2: args2Role-mention-ngram: 1 complext/e2: args2Role-mention-ngram: the Bcl-2-Beclin 1t@CSSPATH: ROOT >conj_and >ccomp >prepc_by >dobj ++ ROOT >conj_andt(e2: args2Role-mention-ngram: resulted int$interceding-token ngrams: Bcl-xL andtEe2: trigger-arg-path: increased >dobj >amod >dep Gene_or_gene_productt$interceding-token ngrams: and Bcl -2tie2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: resultedt=e2: ents2Label-mention-ngram: FAMILY phosphorylation resultedt0e2: ents2Label-mention-ngram: the Bcl-2-Beclin 1t8e2: args2Role-mention-ngram: phosphorylation resulted int?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: Bcl-2-Beclin 1t?e2: trigger-arg-path: increased:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] Familyt[e2: trigger-arg-path: increased >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] Familyt+e2: args2Role-mention-ngram: Bcl-2-Beclin 1tEe2: trigger-arg-path: Positive_activation >dobj >amod >dep controlledt(interceding-token ngrams: between Bcl-xLt?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylation resultedtse2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controllert3e2: ents2Label-mention-ngram: resulted in increasedtVe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn Familyt?e2: trigger-arg-path: Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] Gene_or_gene_productt0e2: args2Role-mention-ngram: dissociation of thet interceding-token ngrams: Bcl -2tinterceding-token ngrams: Bcltje2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >amod >dep Gene_or_gene_productt;e2: trigger-arg-path: Positive_activation >nsubj >nn FamilytMe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn controller:Familyt$interceding-token ngrams: Bcl -2 andtZe2: trigger-arg-path: Positive_activation >dobj >amod >dep controlled:Gene_or_gene_producttEe2: trigger-arg-path: increased:Positive_activation >nsubj >nn Familytfe2: trigger-arg-path: increased >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controller:Familyt*e2: args2Role-mention-ngram: 1 complex andtze2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controller:Familyt4e2: ents2Label-mention-ngram: FAMILY phosphorylationt3e2: args2Role-mention-ngram: Bcl-2-Beclin 1 complextinterceding-token ngrams: 1 .tnsubj >nn controller:Familytee2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] Familyt3e2: args2Role-mention-ngram: increased dissociationtIe2: trigger-arg-path: increased:Positive_activation >nsubj >nn controllertle2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] Familytte2: trigger-arg-path: increased >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlledt.e2: ents2Label-mention-ngram: the Bcl-2-Beclint7e1-label: Generic_event + e2-label: Positive_activationtOe2: trigger-arg-path: increased:Positive_activation >dobj >amod >dep controlledtae2: trigger-arg-path: lemmatizedTrigger=increase >dobj >amod >dep controlled:Gene_or_gene_producttoe2: trigger-arg-path: increased:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] FamilytFinterceding-tokens-full-span: between Bcl-xL and Bcl -2 and Beclin 1 .t5e2: args2Role-mention-ngram: phosphorylation resultedtPe2: trigger-arg-path: increased:Positive_activation >nsubj >nn controller:Familyt?e2: trigger-arg-path: increased >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlled:Gene_or_gene_productt*e2: ents2Label-mention-ngram: Bcl-2-Beclintpe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controllert$interceding-token ngrams: and Beclint-e2: ents2Label-mention-ngram: dissociation oftinterceding-token ngrams: -2tde2: trigger-arg-path: increased:Positive_activation >dobj >amod >dep controlled:Gene_or_gene_producttBe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj >nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controllertZe2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj >nn controllert!interceding-token ngrams: and Bclt?e2: trigger-arg-path: increased:Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlled:Gene_or_gene_producttFe2: trigger-arg-path: Positive_activation >nsubj >nn controller:Familyt interceding-token ngrams: -2 andt3e2: ents2Label-mention-ngram: complex and increasedt?e2: trigger-arg-path: Positive_activation >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlled:Gene_or_gene_productt+e2: ents2Label-mention-ngram: 1 complex andt*e2: ents2Label-mention-ngram: dissociationtwe2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controller:Familyt-e2: args2Role-mention-ngram: the Bcl-2-BeclintYe2: trigger-arg-path: increased:Positive_activation >dobj >amod >dep Gene_or_gene_productt6e2: args2Role-mention-ngram: in increased dissociationtLe2: trigger-arg-path: lemmatizedTrigger=increase >dobj >amod >dep controlledt(interceding-token ngrams: Bcl-xL and Bclt;e2: trigger-arg-path: increased >dobj >amod >dep controlledt$interceding-token ngrams: Beclin 1 .t1e2: ents2Label-mention-ngram: of the Bcl-2-Beclintue2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >amod >dep controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlledt`e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj >amod >dep controlledt6e2: args2Role-mention-ngram: increased dissociation oft?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='Bcl-2'] controller:Familytdobj [lemma='autophagy'] >amod [lemma='dependent'] >dep [lemma='Beclin'] controlledt)e2: args2Role-mention-ngram: Bcl-2-Beclint0interceding-token ngrams: of protein stabilitiest2interceding-token ngrams: their protein activitiestke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt/interceding-token ngrams: affects their proteint]e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] controllert-interceding-token ngrams: protein stabilitiestZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] Gene_or_gene_productt%interceding-token ngrams: stabilitiest$CSSPATH: ROOT >agent >rcmod ++ ROOT t'interceding-token ngrams: affects theirt?interceding-tokens-full-span: affects their protein activities by through regulation of protein stabilities . Similarly with IKKalpha and beta ,tee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_productt'interceding-token ngrams: activities byt$interceding-token ngrams: and beta ,t'interceding-token ngrams: stabilities .tne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt+interceding-token ngrams: IKKalpha and betat(interceding-token ngrams: Similarly witht1interceding-token ngrams: Similarly with IKKalphat interceding-token ngrams: beta ,t'interceding-token ngrams: their proteintIe1: trigger-arg-path: mediated >nsubj [lemma='rsk2'] Gene_or_gene_productt1interceding-token ngrams: stabilities . SimilarlytPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='rsk2'] controllert/interceding-token ngrams: activities by throught/interceding-token ngrams: through regulation oft/interceding-token ngrams: protein activities byt$interceding-token ngrams: by throught/interceding-token ngrams: regulation of proteintSe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] controllert,interceding-token ngrams: protein activitiest?e1: trigger-arg-path: mediated >nsubj [lemma='rsk2'] controllert/interceding-token ngrams: protein stabilities .tte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttOe2: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] Gene_or_gene_producttTe1: trigger-arg-path: mediated >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt/interceding-token ngrams: by through regulationtinterceding-token ngrams: betatde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='rsk2'] controllert"interceding-token ngrams: and betatZe2: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] controller:Gene_or_gene_productt$interceding-token ngrams: activitiestVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='rsk2'] controllerthe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='rsk2'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='rsk2'] controllert,interceding-token ngrams: through regulationtEe2: trigger-arg-path: phosphorylates >nsubj [lemma='rsk2'] controllert*interceding-token ngrams: . Similarly witht$interceding-token ngrams: of proteint}e1: trigger-arg-path: restores:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlled:Gene_or_gene_productt^e1: trigger-arg-path: restores >dobj [lemma='response'] >nn [lemma='p53'] Gene_or_gene_producttte1: trigger-arg-path: Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] Gene_or_gene_productt,e1: args2Role-mention-ngram: RNAi results int#interceding-token ngrams: to stresstie1: trigger-arg-path: restores >dobj [lemma='response'] >nn [lemma='p53'] controlled:Gene_or_gene_productt$interceding-token ngrams: target thet*e1: ents2Label-mention-ngram: and restorestse1: trigger-arg-path: restores:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controllert&interceding-token ngrams: analogs thatt4CSSPATH: ROOT >conj_and ++ ROOT >rcmod >ccomp >nsubjthe1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj >prep_of Gene_or_gene_producttte1: trigger-arg-path: Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: the restoration ofte1: trigger-arg-path: Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controller:Gene_or_gene_productt}e1: trigger-arg-path: restores:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] Gene_or_gene_producttie1: trigger-arg-path: restores >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] Gene_or_gene_producttTe1: trigger-arg-path: restores >dobj [lemma='response'] >nn [lemma='p53'] controlledtee1: trigger-arg-path: lemmatizedTrigger=restore >dobj [lemma='response'] >nn [lemma='p53'] controlledt#interceding-token ngrams: . Nutlinst+e1: args2Role-mention-ngram: of nuclear p53t:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT by RNAitbe1: trigger-arg-path: restores:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt)interceding-token ngrams: cis-imidazolinet*e1: ents2Label-mention-ngram: restores thet+e1: args2Role-mention-ngram: results in thet,e1: ents2Label-mention-ngram: restoration oft)e1: args2Role-mention-ngram: RNAi resultst-interceding-token ngrams: analogs that targett,e1: args2Role-mention-ngram: the restorationt)interceding-token ngrams: that target thetKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] themet!interceding-token ngrams: analogstbe1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj >nn Gene_or_gene_productt)e1: ents2Label-mention-ngram: nuclear p53tpe1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controllert.e1: ents2Label-mention-ngram: and restores thet4e1: args2Role-mention-ngram: restores the CONTROLLEDtGe1: trigger-arg-path: restores:Positive_activation >dobj >nn controlledt)e1: ents2Label-mention-ngram: restorationt!e1: args2Role-mention-ngram: RNAit-e1: ents2Label-mention-ngram: nuclear p53 andt-interceding-token ngrams: are cis-imidazolinetNe1: trigger-arg-path: lemmatizedTrigger=restore >dobj >nn Gene_or_gene_producttZe2: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controller:Gene_or_gene_productt.interceding-token ngrams: mediated response tot-e1: ents2Label-mention-ngram: RNAi results intWe1: trigger-arg-path: restores:Positive_activation >nsubj >prep_of Gene_or_gene_producttointerceding-tokens-full-span: mediated response to stress . Nutlins are cis-imidazoline analogs that target thet9e1: trigger-arg-path: restores >nsubj >prep_of controllert$e1: ents2Label-mention-ngram: in thetse1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj >prep_of controller:Gene_or_gene_producttHe1: trigger-arg-path: restores >dobj >nn controlled:Gene_or_gene_productt,e1: args2Role-mention-ngram: by RNAi resultst_e1: trigger-arg-path: Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlledt%interceding-token ngrams: that targett/e1: args2Role-mention-ngram: CONTROLLER by RNAit1interceding-token ngrams: cis-imidazoline analogst\e1: trigger-arg-path: restores:Positive_activation >dobj >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] Gene_or_gene_productt%interceding-token ngrams: Nutlins aretQe1: trigger-arg-path: restores:Positive_activation >dobj >nn Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: p53 andt$e1: args2Role-mention-ngram: p53 andt/e1: args2Role-mention-ngram: in the restorationt(e1: args2Role-mention-ngram: nuclear p53t-e1: args2Role-mention-ngram: and restores thetNe2: trigger-arg-path: Binding >prep_between [lemma='p53'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj >prep_of controllert'e1: args2Role-mention-ngram: results int(e1: args2Role-mention-ngram: restorationt-e1: ents2Label-mention-ngram: the restorationtoe1: trigger-arg-path: lemmatizedTrigger=restore >dobj [lemma='response'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: . Nutlins aret,e1: ents2Label-mention-ngram: of nuclear p53t%e1: ents2Label-mention-ngram: resultstre1: trigger-arg-path: restores:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj >nn controlledt$e1: args2Role-mention-ngram: resultst1e1: ents2Label-mention-ngram: restores the SHAREDt,interceding-token ngrams: response to stresst=e1: trigger-arg-path: restores >dobj >nn Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_between [lemma='p53'] theme:Gene_or_gene_productt(e1: ents2Label-mention-ngram: results int#e1: args2Role-mention-ngram: in thet?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] Gene_or_gene_producttte1: trigger-arg-path: restores >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controllertCe2: trigger-arg-path: interaction >prep_between [lemma='p53'] themet!interceding-token ngrams: Nutlinst5interceding-token ngrams: Nutlins are cis-imidazolinetCe1: trigger-arg-path: restores >nsubj >prep_of Gene_or_gene_productt*e1: ents2Label-mention-ngram: RNAi resultstRe2: trigger-arg-path: interaction >prep_between [lemma='p53'] Gene_or_gene_producttje1: trigger-arg-path: Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controllertXe2: trigger-arg-path: interaction >prep_between [lemma='p53'] theme:Gene_or_gene_productt5interceding-token ngrams: are cis-imidazoline analogst0e1: ents2Label-mention-ngram: in the restorationt?e2: trigger-arg-path: Binding >prep_between [lemma='p53'] themet]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='p53'] themetNe1: trigger-arg-path: restores >nsubj >prep_of controller:Gene_or_gene_productt%interceding-token ngrams: to stress .t?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: p53 and restorest?e1: trigger-arg-path: restores:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] Gene_or_gene_productt)e1: args2Role-mention-ngram: and restorest,e1: ents2Label-mention-ngram: results in thet-e1: ents2Label-mention-ngram: by RNAi resultstUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='p53'] themetie1: trigger-arg-path: Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: RNAit+e1: args2Role-mention-ngram: restoration oft6interceding-token ngrams: cis-imidazoline analogs thattYe1: trigger-arg-path: lemmatizedTrigger=restore >dobj >nn controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj >nn controlled:Gene_or_gene_productt3e1: args2Role-mention-ngram: restoration of nucleart*interceding-token ngrams: stress . Nutlinsthe1: trigger-arg-path: restores:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlledtMe1: trigger-arg-path: restores:Positive_activation >nsubj >prep_of controllertye1: trigger-arg-path: lemmatizedTrigger=restore:Positive_activation >dobj [lemma='response'] >nn [lemma='p53'] controlledt/e1: args2Role-mention-ngram: the restoration oftDe1: trigger-arg-path: lemmatizedTrigger=restore >dobj >nn controlledt)e1: args2Role-mention-ngram: restores thetze1: trigger-arg-path: lemmatizedTrigger=restore >dobj [lemma='response'] >nn [lemma='p53'] controlled:Gene_or_gene_productt4e1: ents2Label-mention-ngram: restoration of nucleart,e1: args2Role-mention-ngram: nuclear p53 andt3e1: trigger-arg-path: restores >dobj >nn controlledt_e1: trigger-arg-path: restores >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] controllertze1: trigger-arg-path: lemmatizedTrigger=restore >nsubj [lemma='inactivation'] >prep_of [lemma='parc'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: by RNAit`e2: trigger-arg-path: interaction:Binding >prep_between [lemma='p53'] theme:Gene_or_gene_productt+interceding-token ngrams: mediated responset$e1: args2Role-mention-ngram: by RNAit-e1: args2Role-mention-ngram: p53 and restorest.e1: ents2Label-mention-ngram: tightly binds totQe1: trigger-arg-path: binds:Binding >prep_to [lemma='keap1'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrf2'] themetKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='keap1'] themet/interceding-token ngrams: double-glycine repeatt+interceding-token ngrams: DLG motifs withintie2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by controller:Gene_or_gene_productt"interceding-token ngrams: of Keap1t"interceding-token ngrams: repeat (t$interceding-token ngrams: domain andt$interceding-token ngrams: and eithert.e1: args2Role-mention-ngram: homodimeric THEMEtinterceding-token ngrams: DGR )tinterceding-token ngrams: Neh2the1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='keap1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: to homodimerict8interceding-token ngrams: This configuration facilitatestKe1: trigger-arg-path: Binding >prep_to [lemma='keap1'] Gene_or_gene_productt+interceding-token ngrams: motifs within thetAe1: ents2Label-mention-ngram: to homodimeric GENE_OR_GENE_PRODUCTtHe1: trigger-arg-path: Binding >nsubj [lemma='nrf2'] Gene_or_gene_productt"interceding-token ngrams: sites oft2e1: ents2Label-mention-ngram: binds to homodimerict%interceding-token ngrams: Neh2 domaint`e2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by Gene_or_gene_producttinterceding-token ngrams: ETGEt:e2: ents2Label-mention-ngram: polyubiquitination of SHAREDt'interceding-token ngrams: motifs withint%e1: ents2Label-mention-ngram: tightlyt-e1: args2Role-mention-ngram: tightly binds tot$e1: args2Role-mention-ngram: tightlytte2: trigger-arg-path: Positive_regulation prep_by [lemma='cullin3'] Gene_or_gene_productt!interceding-token ngrams: Keap1 .t&interceding-token ngrams: the ETGE andtinterceding-token ngrams: ( DGRt?e2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] controller:Gene_or_gene_productt.interceding-token ngrams: . This configurationt1interceding-token ngrams: double-glycine repeat (t interceding-token ngrams: repeatt3interceding-token ngrams: configuration facilitateste2: trigger-arg-path: Positive_regulation prep_by [lemma='cullin3'] controller:Gene_or_gene_productt,interceding-token ngrams: the double-glycinetTe2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by controllert)e1: ents2Label-mention-ngram: homodimerict?e2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] Gene_or_gene_productt(interceding-token ngrams: and DLG motifst$interceding-token ngrams: one of thetHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrf2'] themetBe1: trigger-arg-path: binds:Binding >prep_to [lemma='keap1'] themet$interceding-token ngrams: ) sites oft1e1: args2Role-mention-ngram: binds to homodimerict?e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by [lemma='cullin3'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='keap1'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='keap1'] Gene_or_gene_productt7e1: trigger-arg-path: binds >nsubj [lemma='nrf2'] themetNe1: trigger-arg-path: binds:Binding >nsubj [lemma='nrf2'] Gene_or_gene_productt1e1: args2Role-mention-ngram: to homodimeric THEMEt+e1: ents2Label-mention-ngram: tightly bindstOe1: trigger-arg-path: binds >prep_to [lemma='keap1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrf2'] Gene_or_gene_productt%interceding-token ngrams: DGR ) sitest>e1: ents2Label-mention-ngram: homodimeric GENE_OR_GENE_PRODUCTt(interceding-token ngrams: and either onet?e1: trigger-arg-path: binds:Binding >nsubj [lemma='nrf2'] themet{e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by [lemma='cullin3'] controllertre2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='nrf2'] theme:Gene_or_gene_productt$interceding-token ngrams: of Keap1 .t?interceding-tokens-full-span: through interaction of the ETGE and DLG motifs within the Neh2 domain and either one of the double-glycine repeat ( DGR ) sites of Keap1 . This configuration facilitatest&interceding-token ngrams: Keap1 . Thist,e1: ents2Label-mention-ngram: to homodimerict9e1: trigger-arg-path: Binding >nsubj [lemma='nrf2'] themet2e1: ents2Label-mention-ngram: SHARED tightly bindst(e1: args2Role-mention-ngram: homodimerictWe1: trigger-arg-path: binds:Binding >prep_to [lemma='keap1'] theme:Gene_or_gene_producttLe2: trigger-arg-path: polyubiquitination prep_by Gene_or_gene_producttke2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by controller:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by controller:Gene_or_gene_productt"interceding-token ngrams: the ETGEt~e2: trigger-arg-path: polyubiquitination prep_by [lemma='cullin3'] controller:Gene_or_gene_producttLe1: trigger-arg-path: binds >nsubj [lemma='nrf2'] theme:Gene_or_gene_productt&interceding-token ngrams: ETGE and DLGt$interceding-token ngrams: DLG motifst!interceding-token ngrams: ( DGR )the2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by controllertTe1: trigger-arg-path: binds:Binding >nsubj [lemma='nrf2'] theme:Gene_or_gene_producttFe1: trigger-arg-path: binds >nsubj [lemma='nrf2'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED tightlyt(interceding-token ngrams: double-glycinet"interceding-token ngrams: the Neh2t)interceding-token ngrams: within the Neh2t]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrf2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] controllertZe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='keap1'] Gene_or_gene_producttinterceding-token ngrams: DLGt)interceding-token ngrams: Neh2 domain andt)interceding-token ngrams: the Neh2 domaint$interceding-token ngrams: either onetWe2: trigger-arg-path: polyubiquitination prep_by controller:Gene_or_gene_producttinterceding-token ngrams: Keap1t,interceding-token ngrams: interaction of thetprep_to [lemma='keap1'] themet:e1: trigger-arg-path: binds >prep_to [lemma='keap1'] themet+interceding-token ngrams: domain and eithert3interceding-token ngrams: the double-glycine repeatt"interceding-token ngrams: ETGE andt interceding-token ngrams: one oft^e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by Gene_or_gene_productt}e2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] controllertWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='nrf2'] Gene_or_gene_productte2: trigger: polyubiquitinationt'interceding-token ngrams: either one oftVe2: trigger-arg-path: polyubiquitination:Positive_regulation prep_by controllertje2: trigger-arg-path: Positive_regulation prep_by [lemma='cullin3'] controllertinterceding-token ngrams: DGRtBe2: trigger-arg-path: polyubiquitination prep_by controllertSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='keap1'] themet?e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination:Positive_regulation prep_by [lemma='cullin3'] Gene_or_gene_productt*e1: args2Role-mention-ngram: tightly bindst!interceding-token ngrams: and DLGt%interceding-token ngrams: of the ETGEtie2: trigger-arg-path: polyubiquitination prep_by [lemma='cullin3'] controllert*e1: args2Role-mention-ngram: THEME tightlytNe1: trigger-arg-path: Binding >nsubj [lemma='nrf2'] theme:Gene_or_gene_productt(interceding-token ngrams: sites of Keap1t?e2: trigger-arg-path: lemmatizedTrigger=polyubiquitination prep_by [lemma='cullin3'] controller:Gene_or_gene_productt,interceding-token ngrams: This configurationt0e1: args2Role-mention-ngram: THEME tightly bindst'interceding-token ngrams: configurationt!interceding-token ngrams: ) sitest CSSPATH: ROOT >dep ++ ROOT >dobjt/interceding-token ngrams: of the double-glycinetse2: trigger-arg-path: polyubiquitination prep_by [lemma='cullin3'] Gene_or_gene_productt&interceding-token ngrams: repeat ( DGRtQe1: trigger-arg-path: Binding >prep_to [lemma='keap1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: binds >prep_to [lemma='keap1'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] themet1e2: ents2Label-mention-ngram: the ternary complext.e2: ents2Label-mention-ngram: complex disruptst"interceding-token ngrams: bound wttinterceding-token ngrams: , GDPtGe2: trigger-arg-path: disrupts >nsubj [lemma='formation'] Generic_eventtte1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: between wtt]e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] Gene_or_gene_productt&interceding-token ngrams: bound wt RastVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] themet-e2: args2Role-mention-ngram: complex disruptstle2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] Generic_eventt-interceding-token ngrams: produce the ternaryt|e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] Gene_or_gene_producttprep_of [lemma='cdc25'] themetXe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] Generic_eventt,e2: ents2Label-mention-ngram: of the ternaryt#interceding-token ngrams: Ras , GDPtOe2: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] controllert?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: of the ternaryt/e2: args2Role-mention-ngram: binding CONTROLLEDtbe1: trigger-arg-path: binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] Gene_or_gene_producttfe2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventt(interceding-token ngrams: the ternary wtt&CSSPATH: ROOT >prep_of >rcmod ++ ROOT t]e2: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventt0e2: args2Role-mention-ngram: the ternary complext)interceding-token ngrams: Cdc25 complex .tze1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] theme:Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] themetQe1: trigger-arg-path: binding >prep_of [lemma='cdc25'] theme:Gene_or_gene_producttDe2: trigger-arg-path: disrupts >nsubj [lemma='formation'] controllert)e2: ents2Label-mention-ngram: the ternaryt(e2: args2Role-mention-ngram: the bindingt9e2: ents2Label-mention-ngram: binding interaction betweentfinterceding-tokens-full-span: bound wt Ras to produce the ternary wt Ras , GDP and Cdc25 complex . Thet+e2: ents2Label-mention-ngram: wt FAMILY andt/e2: ents2Label-mention-ngram: between wt FAMILYtYe1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] theme:Gene_or_gene_producttRe2: trigger-arg-path: disrupts >nsubj [lemma='formation'] controller:Generic_eventt(e2: args2Role-mention-ngram: the ternarytee1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] themet[e2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] Generic_eventtSe1: trigger-arg-path: binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] themetXe2: trigger-arg-path: disrupts:Negative_regulation >nsubj [lemma='formation'] controllert%e2: ents2Label-mention-ngram: ternarythe1: trigger-arg-path: Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: complex disrupts thet9e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT to thet!interceding-token ngrams: GDP andtie2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] controllertee1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] Gene_or_gene_producttDe1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] themetSe1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] Gene_or_gene_producttprep_of [lemma='cdc25'] themetQe1: trigger-arg-path: Binding >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: complex disrupts thetwe2: trigger-arg-path: lemmatizedTrigger=disrupt:Negative_regulation >nsubj [lemma='formation'] controller:Generic_eventt5e2: ents2Label-mention-ngram: the binding interactiontKe1: trigger-arg-path: Binding >prep_of [lemma='cdc25'] Gene_or_gene_producttje1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] Gene_or_gene_productt#interceding-token ngrams: , GDP andtme1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] themet6e2: ents2Label-mention-ngram: ternary complex disruptstce2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] controller:Generic_eventt4e2: ents2Label-mention-ngram: interaction between wtt[e1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] themet-e2: ents2Label-mention-ngram: ternary complext"interceding-token ngrams: wt Ras ,tKe1: trigger-arg-path: binding >prep_of [lemma='cdc25'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=disrupt >nsubj [lemma='formation'] controllert$e2: args2Role-mention-ngram: ternaryt5e2: args2Role-mention-ngram: ternary complex disruptst'interceding-token ngrams: GDP and Cdc25t.e2: args2Role-mention-ngram: CONTROLLER of thet3e2: args2Role-mention-ngram: the binding CONTROLLEDtke1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='cdc25'] theme:Gene_or_gene_productt(interceding-token ngrams: ternary wt Rastpe1: trigger-arg-path: binding:Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: ternary complextce1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='cdc25'] theme:Gene_or_gene_productthe1: trigger-arg-path: binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] theme:Gene_or_gene_productt$interceding-token ngrams: ternary wttbe1: trigger-arg-path: Binding >prep_of [lemma='cdc25'] >prep_to [lemma='GDP'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: wt FAMILYtRe2: trigger-arg-path: Negative_regulation >nsubj [lemma='formation'] Generic_eventt1e2: args2Role-mention-ngram: disrupts the bindingt-interceding-token ngrams: Ras gene expressiont2interceding-token ngrams: gene expression allowingtBe2: trigger-arg-path: activation >prep_by >nn Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLED activationthe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn Gene_or_gene_producttae2: trigger-arg-path: activation:Positive_activation >prep_by >nn controller:Gene_or_gene_producttle2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controllertde2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='maz'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: Positive_activation >nn [lemma='maz'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn controllert2e2: ents2Label-mention-ngram: SHARED activation byt_e2: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by >nn controllertbe2: trigger-arg-path: activation >prep_by [lemma='pathway'] >nn [lemma='map'] Gene_or_gene_producttGe2: trigger-arg-path: activation >nn [lemma='maz'] Gene_or_gene_producttKe2: trigger-arg-path: Positive_activation >prep_by >nn Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='maz'] controlledt'interceding-token ngrams: increases Rast,interceding-token ngrams: increases Ras genet1e1: ents2Label-mention-ngram: FAMILY can increasetxe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='maz'] controlled:Gene_or_gene_productt2interceding-token ngrams: expression allowing moretQe2: trigger-arg-path: activation:Positive_activation >nn [lemma='maz'] controlledt8e2: trigger-arg-path: activation >prep_by >nn controllertAe2: trigger-arg-path: Positive_activation >prep_by >nn controllert'interceding-token ngrams: allowing moret[e2: trigger-arg-path: Positive_activation >nn [lemma='maz'] controlled:Gene_or_gene_producttae2: trigger-arg-path: Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controllert*e2: args2Role-mention-ngram: by activatingtRe2: trigger-arg-path: activation >nn [lemma='maz'] controlled:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='maz'] Gene_or_gene_productt"interceding-token ngrams: Ras genete2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='pathway'] >nn [lemma='map'] controller:Gene_or_gene_productt-interceding-token ngrams: expression allowingt6e2: ents2Label-mention-ngram: activation by activatingt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controller:Gene_or_gene_producttve2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] Gene_or_gene_productt&interceding-token ngrams: more SAF-1 /tVe2: trigger-arg-path: activation:Positive_activation >prep_by >nn Gene_or_gene_productt-interceding-token ngrams: allowing more SAF-1t5e2: args2Role-mention-ngram: by activating CONTROLLERt=e2: trigger-arg-path: activation >nn [lemma='maz'] controlledtFe2: trigger-arg-path: Positive_activation >nn [lemma='maz'] controlledtYe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='maz'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='maz'] controlledt+e2: ents2Label-mention-ngram: by activatingt5e2: args2Role-mention-ngram: CONTROLLED activation bytve2: trigger-arg-path: Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controller:Gene_or_gene_productt?e2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controller:Gene_or_gene_productt[e2: trigger-arg-path: activation:Positive_activation >nn [lemma='maz'] Gene_or_gene_producttXe2: trigger-arg-path: activation >prep_by [lemma='pathway'] >nn [lemma='map'] controllert(e1: ents2Label-mention-ngram: FAMILY cant5e2: args2Role-mention-ngram: activation by activatingtTe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by >nn Gene_or_gene_producttke2: trigger-arg-path: Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='pathway'] >nn [lemma='map'] Gene_or_gene_producttme2: trigger-arg-path: activation >prep_by [lemma='pathway'] >nn [lemma='map'] controller:Gene_or_gene_producttMe2: trigger-arg-path: activation >prep_by >nn controller:Gene_or_gene_productt@e2: ents2Label-mention-ngram: by activating GENE_OR_GENE_PRODUCTt)interceding-token ngrams: , increases Rast2e2: args2Role-mention-ngram: activating CONTROLLERt?interceding-tokens-full-span: . In turn , high level of SAF-1 / MAZ , that is present in the breast cancer cells , increases Ras gene expression allowing more SAF-1 /tfe2: trigger-arg-path: activation:Positive_activation >nn [lemma='maz'] controlled:Gene_or_gene_producttLe2: trigger-arg-path: activation:Positive_activation >prep_by >nn controllert~e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] controllertje2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='pathway'] >nn [lemma='map'] controllert=e2: ents2Label-mention-ngram: activating GENE_OR_GENE_PRODUCTt$interceding-token ngrams: more SAF-1tVe2: trigger-arg-path: Positive_activation >prep_by >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='pathway'] >nn [lemma='map'] Gene_or_gene_producttme2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt)interceding-token ngrams: the assembly oft#interceding-token ngrams: mTORC1 istNe2: trigger-arg-path: phosphorylate >nsubj [lemma='ulk1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: and 2 undergot+interceding-token ngrams: protein complex ,t'interceding-token ngrams: inactivated ,tje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controllert3interceding-token ngrams: autophagosome formation .t"interceding-token ngrams: , mTORC1t?interceding-tokens-full-span: ULK1 and 2 , and mAtg13 , preventing the assembly of a multi protein complex , which is required for autophagosome formation . Under starvation , mTORC1 is inactivated ,t-interceding-token ngrams: mAtg13 , preventingt(e1: ents2Label-mention-ngram: and serinet!interceding-token ngrams: and 2 ,t-e2: args2Role-mention-ngram: CONTROLLER and 2t+interceding-token ngrams: for autophagosomet/interceding-token ngrams: mTORC1 is inactivatedt9e2: ents2Label-mention-ngram: undergo autophosphorylationt)interceding-token ngrams: a multi proteint5interceding-token ngrams: for autophagosome formationt+interceding-token ngrams: which is requiredt*interceding-token ngrams: , preventing thet$interceding-token ngrams: ULK1 and 2t,e2: args2Role-mention-ngram: then CONTROLLEDt'e1: ents2Label-mention-ngram: complex 1t&interceding-token ngrams: the assemblyt.e1: ents2Label-mention-ngram: threonine kinasetbe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_productt!interceding-token ngrams: a multit(e1: ents2Label-mention-ngram: ( mTORC1 )t1interceding-token ngrams: preventing the assemblyt;e2: ents2Label-mention-ngram: undergo autophosphorylation ,tVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] controllert'interceding-token ngrams: multi proteint+e2: ents2Label-mention-ngram: and 2 undergotke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: FAMILY and serinet&e1: ents2Label-mention-ngram: mTORC1 )t%e2: ents2Label-mention-ngram: undergotTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_productt,interceding-token ngrams: . Under starvationt$interceding-token ngrams: and mAtg13t0e2: args2Role-mention-ngram: autophosphorylationt:e2: args2Role-mention-ngram: undergo autophosphorylation ,t/interceding-token ngrams: multi protein complext"e2: args2Role-mention-ngram: and 2t8e2: args2Role-mention-ngram: undergo autophosphorylationt"interceding-token ngrams: mAtg13 ,t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt,interceding-token ngrams: Under starvation ,t,e1: ents2Label-mention-ngram: and serine andt4e2: ents2Label-mention-ngram: and then phosphorylatet2e2: args2Role-mention-ngram: autophosphorylation ,t interceding-token ngrams: mAtg13t)e1: ents2Label-mention-ngram: complex 1 (tJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ulk1'] controllert4interceding-token ngrams: required for autophagosomet&interceding-token ngrams: , preventingt&interceding-token ngrams: and mAtg13 ,t&e1: ents2Label-mention-ngram: ( mTORC1tinterceding-token ngrams: multit6e2: args2Role-mention-ngram: autophosphorylation , andt2e1: ents2Label-mention-ngram: and threonine kinasetnsubj [lemma='ulk1'] controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and 2t%interceding-token ngrams: , mTORC1 istEe2: ents2Label-mention-ngram: then phosphorylate GENE_OR_GENE_PRODUCTt!interceding-token ngrams: 2 , andt(interceding-token ngrams: is inactivatedt1interceding-token ngrams: autophagosome formationtte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] Gene_or_gene_producttAe1: ents2Label-mention-ngram: kinase GENE_OR_GENE_PRODUCT complext7e2: ents2Label-mention-ngram: autophosphorylation , andt'e2: ents2Label-mention-ngram: 2 undergot!interceding-token ngrams: . Undert:e2: args2Role-mention-ngram: 2 undergo autophosphorylationtinterceding-token ngrams: of at;e2: ents2Label-mention-ngram: 2 undergo autophosphorylationt&e2: args2Role-mention-ngram: 2 undergot`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ulk1'] Gene_or_gene_productt$e2: args2Role-mention-ngram: undergotDe2: trigger-arg-path: phosphorylate >nsubj [lemma='ulk1'] controllert+interceding-token ngrams: formation . UndertXe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controllert-interceding-token ngrams: starvation , mTORC1t3e2: ents2Label-mention-ngram: autophosphorylation ,t*interceding-token ngrams: Under starvationtinterceding-token ngrams: 2 ,t"interceding-token ngrams: ULK1 andt9e1: ents2Label-mention-ngram: kinase GENE_OR_GENE_PRODUCTtinterceding-token ngrams: Undert&interceding-token ngrams: starvation ,t5e1: ents2Label-mention-ngram: mTORC1 ) phosphorylateste2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ulk1'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: 1 ( mTORC1t'interceding-token ngrams: assembly of at0e2: args2Role-mention-ngram: and then CONTROLLEDtinterceding-token ngrams: ULK1t0e2: ents2Label-mention-ngram: then phosphorylatetCe1: ents2Label-mention-ngram: threonine kinase GENE_OR_GENE_PRODUCTt*interceding-token ngrams: is inactivated ,t&interceding-token ngrams: , and mAtg13tnsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_producttge2: trigger-arg-path: mediated:Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] controlledt-interceding-token ngrams: leading to enhancedt.interceding-token ngrams: MDM2-p53 interactiontae1: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >nn Gene_or_gene_productt#interceding-token ngrams: with botht+interceding-token ngrams: PA28gamma proteint+e1: ents2Label-mention-ngram: with MDM2 andt&e1: ents2Label-mention-ngram: MDM2 andtde2: trigger-arg-path: lemmatizedTrigger=mediate dobj [lemma='ubiquitination'] controlledt>e2: trigger-arg-path: mediated >dobj controlled:Ubiquitinationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt=e1: trigger-arg-path: induces >nsubj >nn Gene_or_gene_productt&interceding-token ngrams: p53 proteinstbe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert+interceding-token ngrams: protein interactst\e1: trigger-arg-path: induces:Negative_activation >nsubj >nn controller:Gene_or_gene_productt0interceding-token ngrams: MDM2-p53 interaction ,t4CSSPATH: ROOT >conj_and ++ ROOT >vmod >prep_to >vmodtte1: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt[e1: trigger-arg-path: induces:Negative_activation >dobj >nn controlled:Gene_or_gene_producttRe2: trigger-arg-path: mediated:Positive_regulation dobj [lemma='ubiquitination'] Ubiquitinationtle1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt#interceding-token ngrams: PA28gammatme1: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj >nn controller:Gene_or_gene_producttle1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] controlledt5e1: args2Role-mention-ngram: heteroligomers with MDM2tge1: trigger-arg-path: Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt6e1: args2Role-mention-ngram: forms heteroligomers withtYe2: trigger-arg-path: lemmatizedTrigger=mediate dobj [lemma='ubiquitination'] controlled:Ubiquitinationt+e1: args2Role-mention-ngram: heteroligomerstFe1: trigger-arg-path: induces:Negative_activation >dobj >nn controlledt%interceding-token ngrams: . PA28gammatOe2: trigger-arg-path: lemmatizedTrigger=mediate nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: heteroligomers withtUe2: trigger-arg-path: lemmatizedTrigger=mediate dobj [lemma='ubiquitination'] Ubiquitinationtwe1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt&e1: args2Role-mention-ngram: with MDM2t.e1: ents2Label-mention-ngram: MDM2 and inducestSe2: trigger-arg-path: Positive_regulation nsubj >nn Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >nn controllert/interceding-token ngrams: proteins and promotestGe2: trigger-arg-path: mediated:Positive_regulation >dobj Ubiquitinationtoe1: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_producttHe2: trigger-arg-path: mediated dobj [lemma='ubiquitination'] controlledtQe1: trigger-arg-path: induces >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert*e1: args2Role-mention-ngram: with MDM2 andtve1: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert/interceding-token ngrams: interaction , leadingt0e1: ents2Label-mention-ngram: and induces SHAREDt>e2: trigger-arg-path: mediated dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: both MDM2 andt"interceding-token ngrams: MDM2 andt]e1: trigger-arg-path: Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllertSe2: trigger-arg-path: mediated dobj >nn Gene_or_gene_producttze1: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt`e2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='ubiquitination'] Ubiquitinationt%interceding-token ngrams: to enhancedtje1: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledt|e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Ubiquitinationte1: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dobj >nn controlledt^e2: trigger-arg-path: Positive_regulation nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_producttbe1: trigger-arg-path: Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledt&interceding-token ngrams: MDM2 and p53t0interceding-token ngrams: protein interacts witht3e2: trigger-arg-path: mediated >dobj UbiquitinationtWe2: trigger-arg-path: mediated >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation nsubj >nn controllertIe2: trigger-arg-path: Positive_regulation dobj >nn controlled:Gene_or_gene_productt0e1: args2Role-mention-ngram: heteroligomers witht&interceding-token ngrams: the MDM2-p53t2e1: ents2Label-mention-ngram: forms heteroligomerst,e1: ents2Label-mention-ngram: heteroligomerst-e1: args2Role-mention-ngram: MDM2 and inducesthe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='ubiquitination'] controlled:Ubiquitinationtme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >dobj [lemma='ubiquitination'] controlledt'e1: ents2Label-mention-ngram: with MDM2tQe1: trigger-arg-path: induces:Negative_activation >nsubj >nn Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtXe2: trigger-arg-path: mediated:Positive_regulation dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt[e1: trigger-arg-path: induces >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt#interceding-token ngrams: both MDM2tBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttke1: trigger-arg-path: induces >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt7e1: ents2Label-mention-ngram: forms heteroligomers withtMe2: trigger-arg-path: mediated:Positive_regulation nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt-interceding-token ngrams: . PA28gamma proteint1e1: args2Role-mention-ngram: forms heteroligomerst\e2: trigger-arg-path: mediated:Positive_regulation >dobj [lemma='ubiquitination'] controlledtHe1: trigger-arg-path: induces >nsubj >nn controller:Gene_or_gene_producttRe2: trigger-arg-path: mediated:Positive_regulation >dobj controlled:Ubiquitinationtee1: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert3e1: args2Role-mention-ngram: and induces CONTROLLEDtLe2: trigger-arg-path: mediated >dobj [lemma='ubiquitination'] Ubiquitinationt\e2: trigger-arg-path: mediated:Positive_regulation prep_with [lemma='pi3kc2beta'] themetFe1: trigger-arg-path: interacted >prep_with [lemma='pi3kc2beta'] themetNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ras17n'] themet!interceding-token ngrams: RasWT .tee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt,e1: args2Role-mention-ngram: interacted mosttke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] themet]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] Gene_or_gene_producttce2: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ras17n'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ras17n'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: strongly with THEMEt*e1: args2Role-mention-ngram: strongly withtPe1: trigger-arg-path: Binding >nsubj [lemma='ras17n'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_productt[e1: trigger-arg-path: interacted >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt_e2: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttRe2: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] themetVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ras17n'] themetUe1: trigger-arg-path: interacted:Binding >nsubj [lemma='ras17n'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ras17n'] Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: most strongly withtce1: trigger-arg-path: interacted:Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: most stronglytke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ras17n'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED interacted mosttBe2: trigger-arg-path: Binding >prep_between [lemma='ras17n'] themetFe2: trigger-arg-path: interaction >prep_between [lemma='ras17n'] themetWe2: trigger-arg-path: Binding >prep_between [lemma='ras17n'] theme:Gene_or_gene_producttXe1: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt%interceding-token ngrams: RasWT . ThetSe1: trigger-arg-path: interacted >nsubj [lemma='ras17n'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt$interceding-token ngrams: by RasWT .t[e1: trigger-arg-path: interacted:Binding >nsubj [lemma='ras17n'] theme:Gene_or_gene_productt[e2: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: mostt0e1: ents2Label-mention-ngram: most strongly withtse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] themetUe2: trigger-arg-path: interaction >prep_between [lemma='ras17n'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pi3kc2beta'] themet]e1: trigger-arg-path: interacted:Binding >prep_with [lemma='pi3kc2beta'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: interacted mostt5interceding-tokens-full-span: followed by RasWT . Thet\e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='pi3kc2beta'] themetae2: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pi3kc2beta'] theme:Gene_or_gene_producttJe2: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] themetCe1: trigger-arg-path: Binding >prep_with [lemma='pi3kc2beta'] themetYe2: trigger-arg-path: interaction >prep_between [lemma='pi3kc2beta'] Gene_or_gene_productt+interceding-token ngrams: followed by RasWTtMe1: trigger-arg-path: interacted >nsubj [lemma='ras17n'] Gene_or_gene_producttJe1: trigger-arg-path: Binding >nsubj [lemma='ras17n'] Gene_or_gene_producttNe1: trigger-arg-path: interacted:Binding >prep_with [lemma='pi3kc2beta'] themet+e1: ents2Label-mention-ngram: strongly witht"interceding-token ngrams: by RasWTt[e2: trigger-arg-path: interaction >prep_between [lemma='ras17n'] theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >nsubj [lemma='ras17n'] themetge2: trigger-arg-path: interaction:Binding >prep_between [lemma='pi3kc2beta'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interacted:Binding >nsubj [lemma='ras17n'] themetinterceding-token ngrams: RasWTt>e1: trigger-arg-path: interacted >nsubj [lemma='ras17n'] themet6e1: ents2Label-mention-ngram: interacted most stronglytNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ras17n'] themet2e1: args2Role-mention-ngram: THEME interacted mostt+e1: ents2Label-mention-ngram: most stronglyt"e1: ents2Label-mention-ngram: mosttUe1: trigger-arg-path: interacted >prep_with [lemma='pi3kc2beta'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ras17n'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ras17n'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='pi3kc2beta'] themetFe2: trigger-arg-path: Binding >prep_between [lemma='pi3kc2beta'] themet5e1: args2Role-mention-ngram: interacted most stronglyt2e1: ents2Label-mention-ngram: strongly with SHAREDtQe2: trigger-arg-path: Binding >prep_between [lemma='ras17n'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: PGAM provokes GENERIC_ENTITYt6e2: ents2Label-mention-ngram: a transcriptional targett%e2: args2Role-mention-ngram: of p53 ,tle1: trigger-arg-path: Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlledt4e2: ents2Label-mention-ngram: transcriptional targett!e1: args2Role-mention-ngram: PGAMtee1: trigger-arg-path: mediated >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] Ubiquitinationt+e2: ents2Label-mention-ngram: target of p53t&interceding-token ngrams: and turnovert%e1: args2Role-mention-ngram: provokest5e2: args2Role-mention-ngram: a transcriptional targettye1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] UbiquitinationtPe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] controllertVe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >dobj controlled:Ubiquitinationt&e1: ents2Label-mention-ngram: provokest*e1: args2Role-mention-ngram: PGAM provokest_e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >dobj UbiquitinationtSe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] controllert?e1: trigger-arg-path: mediated >nsubj [lemma='pak1'] controllertde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] controllertye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_productt)interceding-token ngrams: . The ubiquitinthe1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >dobj Ubiquitinationt.interceding-token ngrams: The ubiquitin ligaset5e1: ents2Label-mention-ngram: phosphorylation of PGAMt&e2: ents2Label-mention-ngram: of p53 ,tPe1: trigger-arg-path: Positive_regulation >ccomp >dobj controlled:Ubiquitinationt(interceding-token ngrams: and turnover .t;e1: ents2Label-mention-ngram: GENERIC_ENTITY ubiquitinationt1e2: ents2Label-mention-ngram: , a transcriptionaltJe1: trigger-arg-path: mediated:Positive_regulation >ccomp >dobj controlledt$e1: args2Role-mention-ngram: of PGAMt(interceding-token ngrams: turnover . Thet'e2: args2Role-mention-ngram: , binds totre1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlledt:e1: trigger-arg-path: mediated >ccomp >dobj Ubiquitinationt%e2: ents2Label-mention-ngram: , bindstEe1: trigger-arg-path: mediated >ccomp >dobj controlled:Ubiquitinationt'interceding-token ngrams: The ubiquitintje1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >dobj controlled:Ubiquitinationt$interceding-token ngrams: turnover .t.e2: args2Role-mention-ngram: to and CONTROLLEDt(e2: ents2Label-mention-ngram: , binds tot%e1: ents2Label-mention-ngram: of PGAMt6e2: ents2Label-mention-ngram: and ubiquitinates FAMILYtpe1: trigger-arg-path: mediated >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt"e1: ents2Label-mention-ngram: PGAMt[e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp >dobj controlledt)e2: ents2Label-mention-ngram: p53 , bindst]e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_producttYe1: trigger-arg-path: mediated:Positive_regulation >ccomp >dobj controlled:Ubiquitinationt4e1: args2Role-mention-ngram: phosphorylation of PGAMtne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: p53 , bindst2e2: ents2Label-mention-ngram: ubiquitinates FAMILYtpe1: trigger-arg-path: Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] Ubiquitinationtve1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] Ubiquitinationt.e1: ents2Label-mention-ngram: of PGAM provokest2e2: ents2Label-mention-ngram: to and ubiquitinatestZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt0e2: args2Role-mention-ngram: , a transcriptionalt6e2: args2Role-mention-ngram: transcriptional target oftGe1: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >dobj controlledt3e2: args2Role-mention-ngram: transcriptional targettEe1: trigger-arg-path: Positive_regulation >ccomp >dobj Ubiquitinationt?e1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt.e2: args2Role-mention-ngram: a transcriptionaltee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='pak1'] controller:Gene_or_gene_productt{e1: trigger-arg-path: Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt/e2: ents2Label-mention-ngram: and ubiquitinatest5e1: ents2Label-mention-ngram: provokes GENERIC_ENTITYt$e2: args2Role-mention-ngram: , bindst?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlled:Ubiquitinationt+e1: ents2Label-mention-ngram: PGAM provokestAe1: trigger-arg-path: Positive_regulation >ccomp >dobj controlledtae1: trigger-arg-path: mediated >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlledt5e1: args2Role-mention-ngram: PGAM provokes CONTROLLEDt"e2: args2Role-mention-ngram: p53 ,t@e1: args2Role-mention-ngram: CONTROLLER mediated phosphorylationt5e1: args2Role-mention-ngram: mediated phosphorylationt-e1: args2Role-mention-ngram: of PGAM provokest#e2: ents2Label-mention-ngram: p53 ,tAinterceding-tokens-full-span: and turnover . The ubiquitin ligaset?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] Ubiquitinationt/e2: ents2Label-mention-ngram: a transcriptionaltJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] controllert6e1: trigger-arg-path: mediated >ccomp >dobj controlledt0e1: args2Role-mention-ngram: provokes CONTROLLEDt8e1: args2Role-mention-ngram: mediated phosphorylation oft*e2: args2Role-mention-ngram: target of p53t7e2: ents2Label-mention-ngram: transcriptional target oftTe1: trigger-arg-path: mediated >nsubj [lemma='pak1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlledtIe1: trigger-arg-path: mediated >nsubj [lemma='pak1'] Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_producttDe1: ents2Label-mention-ngram: provokes GENERIC_ENTITY ubiquitinationtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_producttNe1: trigger-arg-path: mediated:Positive_regulation >ccomp >dobj Ubiquitinationtue1: trigger-arg-path: mediated:Positive_regulation >ccomp [lemma='provoke'] >dobj [lemma='ubiquitination'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controllert interceding-token ngrams: for S6t4e1: trigger-arg-path: enhanced >dobj Phosphorylationtce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation dobj [lemma='phosphorylation'] controlled:Phosphorylationt0interceding-token ngrams: for S6 phosphorylationt)interceding-token ngrams: S6 activation ,t5interceding-token ngrams: which consequently resultedt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='s6'] controlled:Familyt interceding-token ngrams: p90RSKt,interceding-token ngrams: via overactivatingt]e2: trigger-arg-path: Positive_activation nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controllertde2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='s6'] Familyt"interceding-token ngrams: resultedt%interceding-token ngrams: resulted int(e1: args2Role-mention-ngram: by knockoutt/e1: trigger-arg-path: enhanced >dobj controlledt&interceding-token ngrams: response viate1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controllert+interceding-token ngrams: arsenite responset1e1: args2Role-mention-ngram: efficiently enhancedt)interceding-token ngrams: 90kDa ribosomaltGe1: trigger-arg-path: enhanced >nsubj >prep_of >nn Gene_or_gene_producttRe2: trigger-arg-path: induced:Positive_activation nsubj >prep_of >nn controllertje1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: enhanced >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='phosphorylation'] controlled:Phosphorylationt=e1: ents2Label-mention-ngram: enhanced SHARED phosphorylationtge2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='s6'] controlled:FamilytZe2: trigger-arg-path: induced:Positive_activation dobj [lemma='phosphorylation'] Phosphorylationtae2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='s6'] Familyt.interceding-token ngrams: , which consequentlytXe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controller:Gene_or_gene_productt+interceding-token ngrams: was also involvedtQe1: trigger-arg-path: enhanced:Positive_regulation >nsubj >prep_of >nn controllertle2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='s6'] controlled:Familytfe1: trigger-arg-path: enhanced:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt&interceding-token ngrams: PI3K and AKTt#interceding-token ngrams: ribosomalt&interceding-token ngrams: blocking AKTtse1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtIe1: trigger-arg-path: enhanced >dobj [lemma='phosphorylation'] controlledt'interceding-token ngrams: ERK pathway ,t+interceding-token ngrams: Ras/Raf/MEK / ERKtSe1: trigger-arg-path: enhanced:Positive_regulation >dobj controlled:Phosphorylationt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controller:Gene_or_gene_productt)interceding-token ngrams: a direct kinaset,interceding-token ngrams: the stimulation oftde1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj controlled:Phosphorylationt]e1: trigger-arg-path: enhanced:Positive_regulation >dobj [lemma='phosphorylation'] controlledt&interceding-token ngrams: ribosomal S6t~e1: trigger-arg-path: enhanced >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] Gene_or_gene_productt?e1: trigger-arg-path: enhanced >dobj controlled:PhosphorylationtZe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='phosphorylation'] controlledt3e1: args2Role-mention-ngram: knockout and knockdowntee2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='s6'] controlledtYe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj Phosphorylationt1e1: args2Role-mention-ngram: knockdown approachest'interceding-token ngrams: / ERK pathwaytwe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj >prep_of >nn controller:Gene_or_gene_productt.interceding-token ngrams: S6 phosphorylation .t'interceding-token ngrams: kinase for S6t9e2: trigger-arg-path: induced >dobj >nn controlled:Familyt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controllert,interceding-token ngrams: which consequentlytRe1: trigger-arg-path: enhanced >nsubj >prep_of >nn controller:Gene_or_gene_productt)interceding-token ngrams: AKT pathway wast4e1: ents2Label-mention-ngram: knockout and knockdowntinterceding-token ngrams: 90kDat?e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] Gene_or_gene_producttTe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='s6'] controlledthe2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='s6'] controlledt/interceding-token ngrams: stimulation of p90RSKt)interceding-token ngrams: pathway , whicht3e1: args2Role-mention-ngram: expression by knockoutt(interceding-token ngrams: activation didt%interceding-token ngrams: Ras/Raf/MEKt?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn controlled:Familytinterceding-token ngrams: S6t+interceding-token ngrams: phosphorylation .t*e1: args2Role-mention-ngram: and knockdowntSe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn FamilytWe2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] Gene_or_gene_producttPe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='s6'] Familyt)interceding-token ngrams: the stimulationt=e1: args2Role-mention-ngram: knockdown approaches efficientlyt*interceding-token ngrams: also involved int%interceding-token ngrams: S6 kinase )t.interceding-token ngrams: in arsenite responset4e1: ents2Label-mention-ngram: approaches efficientlyt+interceding-token ngrams: p70S6K activationt+interceding-token ngrams: Although PI3K andt6e1: ents2Label-mention-ngram: and knockdown approachest4e1: ents2Label-mention-ngram: expression by knockouttye2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='s6'] controlledtce1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn controller:Gene_or_gene_producttRe2: trigger-arg-path: Positive_activation dobj [lemma='phosphorylation'] controlled:Phosphorylationt'interceding-token ngrams: Ras/Raf/MEK /t?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] Gene_or_gene_producttdobj controlled:Phosphorylationt)e1: args2Role-mention-ngram: knockout andt'interceding-token ngrams: direct kinaset%interceding-token ngrams: AKT pathwayt,interceding-token ngrams: activation did nottJe2: trigger-arg-path: Positive_activation dobj [lemma='activation'] >nn [lemma='s6'] Familyt5e1: args2Role-mention-ngram: and knockdown approachest$interceding-token ngrams: kinase ) ,t>e1: ents2Label-mention-ngram: knockdown approaches efficientlyt?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj >nn Familytke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation dobj >nn Familyt=e1: ents2Label-mention-ngram: approaches efficiently enhancedt$interceding-token ngrams: and p70S6Ktee2: trigger-arg-path: induced:Positive_activation nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controller:Gene_or_gene_productt*interceding-token ngrams: pathway was alsotHe1: trigger-arg-path: enhanced:Positive_regulation >dobj Phosphorylationt[e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='s6'] controlled:Familyt)interceding-token ngrams: . Although PI3KtRe2: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of >nn Gene_or_gene_productt?e1: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] Gene_or_gene_productt6interceding-token ngrams: overactivating Ras/Raf/MEK /tnsubj >prep_of >nn Gene_or_gene_producttUe2: trigger-arg-path: induced:Positive_activation dobj [lemma='activation'] >nn [lemma='s6'] Familyt/interceding-token ngrams: arsenite response viat interceding-token ngrams: p70S6Kt%interceding-token ngrams: involved int?e2: trigger-arg-path: Positive_activation dobj [lemma='activation'] >nn [lemma='s6'] controlled:Familyt%interceding-token ngrams: in arsenitetNe1: trigger-arg-path: enhanced >dobj [lemma='phosphorylation'] Phosphorylationt)e1: ents2Label-mention-ngram: by knockouttCe1: trigger-arg-path: enhanced:Positive_regulation >dobj controlledt(e1: ents2Label-mention-ngram: approachestFe2: trigger-arg-path: induced dobj [lemma='activation'] >nn [lemma='s6'] controlledt+interceding-token ngrams: ( 90kDa ribosomaltQe2: trigger-arg-path: induced dobj [lemma='phosphorylation'] Phosphorylationt^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj >nn controlled:Familyt/interceding-token ngrams: and p70S6K activationt(interceding-token ngrams: p90RSK ( 90kDat2interceding-token ngrams: consequently resulted int'interceding-token ngrams: not attenuatetinterceding-token ngrams: in S6t(interceding-token ngrams: overactivatingt4interceding-token ngrams: overactivating Ras/Raf/MEKt"interceding-token ngrams: kinase )tfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation dobj PhosphorylationtAe2: trigger-arg-path: induced ccomp ++ ROOT >conj_and >dobj >vmodt/interceding-token ngrams: consequently resultedtNe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj >prep_of >nn controllert%e1: args2Role-mention-ngram: knockoutt/interceding-token ngrams: activation , blockingt*interceding-token ngrams: in S6 activationt'interceding-token ngrams: Although PI3Kt%interceding-token ngrams: pathway wast?e1: trigger-arg-path: enhanced:Positive_regulation >nsubj [lemma='depletion'] >prep_of [lemma='expression'] >nn [lemma='p27'] controllert#interceding-token ngrams: of p90RSKtinterceding-token ngrams: / ERKt+interceding-token ngrams: direct kinase fortBe2: trigger-arg-path: induced:Positive_activation >dobj >nn Familyt5e1: args2Role-mention-ngram: CONTROLLER expression byt&e1: ents2Label-mention-ngram: knockoutt=e1: trigger-arg-path: enhanced >nsubj >prep_of >nn controllert'e1: args2Role-mention-ngram: approachest*interceding-token ngrams: blocking AKT andtMe2: trigger-arg-path: induced:Positive_activation >dobj >nn controlled:Familytje2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation dobj Phosphorylationt>e1: trigger-arg-path: mediated >agent >nn Gene_or_gene_productt>e2: trigger-arg-path: lemmatizedTrigger=drive e2: trigger-arg-path: lemmatizedTrigger=drive >dobj controlledtBe2: trigger-arg-path: driven nsubjpass [lemma='phosphorylation'] Generic_eventt]e2: trigger-arg-path: Positive_regulation dobj controlledtRe2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation nsubjpass Generic_eventt"interceding-token ngrams: rsk thattOe1: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn controllert9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT drivent?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtSe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass controlled:Generic_eventtEe1: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn controllert7e2: trigger-arg-path: driven agent [lemma='rsk'] >nn [lemma='p90'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=drive >dobj [lemma='phosphorylation'] PhosphorylationtCe2: trigger-arg-path: lemmatizedTrigger=drive >dobj Phosphorylationtle2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation >dobj [lemma='phosphorylation'] controlledt4e1: args2Role-mention-ngram: CONTROLLED was mediatedtbe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass [lemma='phosphorylation'] Generic_eventtRe2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation >dobj controlledtpe1: trigger-arg-path: mediated:Positive_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt(interceding-token ngrams: Erk . AlthoughtBe1: trigger-arg-path: mediated >nsubjpass controlled:Generic_eventtOe2: trigger-arg-path: driven:Positive_regulation dobj [lemma='phosphorylation'] controlled:Phosphorylationt.e2: args2Role-mention-ngram: driven CONTROLLEDtbe1: trigger-arg-path: mediated:Positive_regulation >nsubjpass [lemma='phosphorylation'] controlledt]e1: trigger-arg-path: mediated:Positive_regulation >agent >nn controller:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation nsubjpass controlledtne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn controller:Gene_or_gene_producttke2: trigger-arg-path: driven:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt#e2: args2Role-mention-ngram: drivent\e1: trigger-arg-path: Positive_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventt"interceding-token ngrams: by Erk .tFe2: trigger-arg-path: driven:Positive_regulation >dobj Phosphorylationtee1: trigger-arg-path: mediated >agent [lemma='rsk'] >nn [lemma='p90'] controller:Gene_or_gene_producttde1: trigger-arg-path: mediated:Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] controllertQe2: trigger-arg-path: driven:Positive_regulation >dobj controlled:PhosphorylationtVe2: trigger-arg-path: lemmatizedTrigger=drive nsubjpass [lemma='phosphorylation'] controlledt3e1: args2Role-mention-ngram: mediated by CONTROLLERtZe1: trigger-arg-path: lemmatizedTrigger=mediate >agent >nn controller:Gene_or_gene_producttEe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass controlledtke1: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='rsk'] >nn [lemma='p90'] Gene_or_gene_productt;e2: trigger-arg-path: driven agent [lemma='rsk'] >nn [lemma='p90'] controller:Gene_or_gene_productt-e2: trigger-arg-path: driven >dobj controlledt$interceding-token ngrams: was itselftse1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='phosphorylation'] controlledt)e1: args2Role-mention-ngram: was mediatedt.e2: args2Role-mention-ngram: CONTROLLER driventNe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT driven GENE_OR_GENE_PRODUCTtinterceding-token ngrams: Erk .t7e1: trigger-arg-path: mediated >nsubjpass Generic_eventt\e1: trigger-arg-path: mediated >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventtae1: trigger-arg-path: lemmatizedTrigger=mediate >agent [lemma='rsk'] >nn [lemma='p90'] controllertEe2: trigger-arg-path: driven ccomp ++ ROOT >advcl >nsubj >vmodt:e1: ents2Label-mention-ngram: phosphorylation was mediatedt&interceding-token ngrams: rsk that wastve1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass [lemma='phosphorylation'] Generic_eventtHe2: trigger-arg-path: Positive_regulation agent >nn controller:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=drive >dobj [lemma='phosphorylation'] controlledtLe2: trigger-arg-path: lemmatizedTrigger=drive nsubjpass controlled:Generic_eventt4e1: trigger-arg-path: mediated >agent >nn controllertne1: trigger-arg-path: mediated:Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] Gene_or_gene_productt`e2: trigger-arg-path: driven:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtPe2: trigger-arg-path: driven nsubjpass controlledt)interceding-token ngrams: that was itselftHe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubjpass Generic_eventtue1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] controllertae2: trigger-arg-path: lemmatizedTrigger=drive agent >nn Gene_or_gene_producttQe1: trigger-arg-path: mediated >nsubjpass [lemma='phosphorylation'] Generic_eventtYe1: trigger-arg-path: Positive_regulation >nsubjpass [lemma='phosphorylation'] controlledt.interceding-token ngrams: was itself activatedtee1: trigger-arg-path: Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] Gene_or_gene_producttde2: trigger-arg-path: driven:Positive_regulation nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt\e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubjpass Generic_eventt=e2: trigger-arg-path: driven >dobj controlled:Phosphorylationte2: trigger: driventMe1: trigger-arg-path: Positive_regulation >nsubjpass controlled:Generic_eventt-interceding-token ngrams: itself activated bytHe1: trigger-arg-path: mediated:Positive_regulation >agent >nn controllert-e1: ents2Label-mention-ngram: was mediated byt[e2: trigger-arg-path: driven:Positive_regulation >dobj [lemma='phosphorylation'] controlledt`e2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation dobj [lemma='phosphorylation'] Phosphorylationtpe1: trigger-arg-path: Positive_regulation >agent [lemma='rsk'] >nn [lemma='p90'] controller:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation >dobj [lemma='phosphorylation'] PhosphorylationtYe2: trigger-arg-path: driven:Positive_regulation agent [lemma='rsk'] >nn [lemma='p90'] controller:Gene_or_gene_productt9e2: ents2Label-mention-ngram: driven GENE_OR_GENE_PRODUCTt*interceding-token ngrams: activated by ErktGe2: trigger-arg-path: driven >dobj [lemma='phosphorylation'] controlledt>e1: ents2Label-mention-ngram: mediated by GENE_OR_GENE_PRODUCTtAe2: trigger-arg-path: driven:Positive_regulation agent [lemma='rsk'] >nn [lemma='p90'] controllertPe1: trigger-arg-path: mediated >agent [lemma='rsk'] >nn [lemma='p90'] controllert*e1: ents2Label-mention-ngram: was mediatedtRe2: trigger-arg-path: Positive_regulation nsubjpass Generic_eventtge1: trigger-arg-path: Positive_regulation >nsubjpass [lemma='phosphorylation'] controlled:Generic_eventt?e1: trigger-arg-path: Positive_regulation >nsubjpass controlledtHe1: trigger-arg-path: mediated:Positive_regulation >nsubjpass controlledtWe2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation >dobj Phosphorylationt\e2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation dobj [lemma='phosphorylation'] controlled:PhosphorylationtVe1: trigger-arg-path: mediated:Positive_regulation >nsubjpass controlled:Generic_eventtWe2: trigger-arg-path: driven >dobj [lemma='phosphorylation'] controlled:PhosphorylationtNe2: trigger-arg-path: lemmatizedTrigger=drive >dobj controlled:PhosphorylationtNe1: trigger-arg-path: mediated >nsubjpass [lemma='phosphorylation'] controlledtce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >agent >nn Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=drive:Positive_regulation >dobj controlled:Phosphorylationt,e2: args2Role-mention-ngram: then associatest interceding-token ngrams: 4E-BP1tMe2: trigger-arg-path: Binding >prep_with [lemma='eif4g'] Gene_or_gene_productt"interceding-token ngrams: . 4E-BP1t+interceding-token ngrams: by mTORC1 resultstae2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='eif4g'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='eif4g'] theme:Gene_or_gene_producttJe2: trigger-arg-path: associates:Binding prep_with [lemma='eif4g'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='eif4g'] themet+interceding-token ngrams: mTORC1 results int%interceding-token ngrams: the releaset2e2: args2Role-mention-ngram: which then associatest>e2: trigger-arg-path: Binding >prep_with [lemma='eif4g'] themetie2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='eif4g'] Gene_or_gene_producttPe2: trigger-arg-path: associates >prep_with [lemma='eif4g'] Gene_or_gene_productt#interceding-token ngrams: by mTORC1t1e2: args2Role-mention-ngram: then associates witht(interceding-token ngrams: eIF4E . 4E-BP1tTe2: trigger-arg-path: associates:Binding prep_with [lemma='eif4g'] themet0interceding-token ngrams: 4E-BP1 phosphorylationt(interceding-token ngrams: mTORC1 resultstoe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='eif4g'] theme:Gene_or_gene_productt2interceding-token ngrams: . 4E-BP1 phosphorylationt(interceding-token ngrams: results in thetinterceding-tokens-full-span: and prevents the formation of the 4F translational initiation complex ( eIF4F ) ; by competing for the binding of eukaryotic initiation factor 4G ( eIF4G ) to eIF4E . 4E-BP1 phosphorylation by mTORC1 results in the release of thetAe2: trigger-arg-path: associates >prep_with [lemma='eif4g'] themetVe2: trigger-arg-path: associates >prep_with [lemma='eif4g'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_with [lemma='eif4g'] theme:Gene_or_gene_productt3e2: ents2Label-mention-ngram: which then associatestLe2: trigger-arg-path: associates prep_in >prep_of >rcmodt3interceding-token ngrams: 4E-BP1 phosphorylation byt4e1: ents2Label-mention-ngram: binding protein SHAREDtBe2: trigger-arg-path: associates prep_with [lemma='eif4g'] Gene_or_gene_productt(interceding-token ngrams: in the releasetNe2: trigger-arg-path: lemmatizedTrigger=associate prep_with [lemma='eif4g'] themetNe1: trigger-arg-path: stimulation nsubjpass >nn Gene_or_gene_productt interceding-token ngrams: sortedt\e1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='egf'] Gene_or_gene_producttve1: trigger-arg-path: stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlledt0e1: ents2Label-mention-ngram: stimulation SHAREDt!interceding-token ngrams: evadingt!interceding-token ngrams: examplet?e1: trigger-arg-path: Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] Gene_or_gene_producttKe2: trigger-arg-path: heterodimers >nn [lemma='erbb2'] Gene_or_gene_productt)interceding-token ngrams: and are insteadtRe2: trigger-arg-path: heterodimers:Binding >nn [lemma='egfr'] Gene_or_gene_producttDe1: trigger-arg-path: stimulation nsubjpass >nn controlledtFe2: trigger-arg-path: Binding >nn [lemma='erbb2'] Gene_or_gene_productt%interceding-token ngrams: For exampletSe2: trigger-arg-path: heterodimers:Binding >nn [lemma='erbb2'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erbb2'] themet>e1: trigger-arg-path: stimulation >nn [lemma='egf'] controllertJe2: trigger-arg-path: heterodimers >nn [lemma='egfr'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='egfr'] theme:Gene_or_gene_productt'interceding-token ngrams: . For examplet$interceding-token ngrams: are sortedt'interceding-token ngrams: For example ,t-interceding-token ngrams: degradation and aret1interceding-token ngrams: evading degradation andtme1: trigger-arg-path: stimulation:Positive_activation nsubjpass >nn controlled:Gene_or_gene_productt$interceding-token ngrams: homodimerst(interceding-token ngrams: recycled . FortRe1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='egf'] controllertbe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erbb2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlledt?e1: trigger-arg-path: Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttnn [lemma='erbb2'] themet-interceding-token ngrams: , heterodimers failt>e1: args2Role-mention-ngram: CONTROLLER stimulation CONTROLLEDt?e1: trigger-arg-path: stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: Positive_activation nsubjpass >nn controlledtinterceding-token ngrams: Cbl ,t$interceding-token ngrams: to recruitt%interceding-token ngrams: are insteadtVe1: trigger-arg-path: Positive_activation nsubjpass >nn Gene_or_gene_productt/interceding-token ngrams: homodimers are sortedt(interceding-token ngrams: homodimers aretTe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='egfr'] themet"interceding-token ngrams: recycledt`e1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass >nn Gene_or_gene_producttHe1: trigger-arg-path: stimulation >nn [lemma='egf'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='egf'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='egfr'] Gene_or_gene_productt&interceding-token ngrams: heterodimerst3e1: args2Role-mention-ngram: stimulation CONTROLLEDtae1: trigger-arg-path: Positive_activation nsubjpass >nn controlled:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='egfr'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass >nn controlledtte1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass >nn Gene_or_gene_productt+interceding-token ngrams: , thereby evadingt'interceding-token ngrams: recruit Cbl ,tCe2: ents2Label-mention-ngram: and GENE_OR_GENE_PRODUCT heterodimerstee1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='egf'] controller:Gene_or_gene_productt0interceding-token ngrams: sorted for degradationtCe2: trigger-arg-path: heterodimers:Binding >nn [lemma='egfr'] themet.interceding-token ngrams: are instead recycledt7e2: trigger-arg-path: Binding >nn [lemma='erbb2'] themetinterceding-token ngrams: failtDe2: trigger-arg-path: heterodimers:Binding >nn [lemma='erbb2'] themetce2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='egfr'] Gene_or_gene_producttge1: trigger-arg-path: stimulation:Positive_activation >nn [lemma='egf'] controller:Gene_or_gene_productt)interceding-token ngrams: for degradationt?e1: trigger-arg-path: stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlledtYe1: trigger-arg-path: stimulation nsubjpass >nn controlled:Gene_or_gene_productt)interceding-token ngrams: thereby evadingtLe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='egfr'] themet%interceding-token ngrams: recruit Cbltde1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='egf'] controllertPe1: trigger-arg-path: lemmatizedTrigger=stimulation >nn [lemma='egf'] controllertPe2: trigger-arg-path: heterodimers >nn [lemma='egfr'] theme:Gene_or_gene_producttbe1: trigger-arg-path: stimulation:Positive_activation nsubjpass >nn Gene_or_gene_productt'interceding-token ngrams: Cbl , therebyt(interceding-token ngrams: are sorted fortye1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='egf'] controller:Gene_or_gene_producttinterceding-token ngrams: Cblte1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlled:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erbb2'] theme:Gene_or_gene_producttYe2: trigger-arg-path: heterodimers:Binding >nn [lemma='erbb2'] theme:Gene_or_gene_productt;e2: trigger-arg-path: heterodimers >nn [lemma='egfr'] themetPe1: trigger-arg-path: Positive_activation >nn [lemma='egf'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass >nn controlledtSe1: trigger-arg-path: stimulation >nn [lemma='egf'] controller:Gene_or_gene_productt-interceding-token ngrams: evading degradationt?e1: trigger-arg-path: stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlled:Gene_or_gene_productt*interceding-token ngrams: instead recycledt,interceding-token ngrams: instead recycled .tEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation SHAREDtQe2: trigger-arg-path: heterodimers >nn [lemma='erbb2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlled:Gene_or_gene_productt)interceding-token ngrams: fail to recruitt~e1: trigger-arg-path: Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlledt?e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT heterodimerstLe2: trigger-arg-path: Binding >nn [lemma='erbb2'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation >nn [lemma='egf'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erbb2'] Gene_or_gene_productt$interceding-token ngrams: recycled .t+interceding-token ngrams: for degradation ,tXe1: trigger-arg-path: stimulation:Positive_activation nsubjpass >nn controlledtde2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erbb2'] Gene_or_gene_productt?interceding-tokens-full-span: homodimers are sorted for degradation , heterodimers fail to recruit Cbl , thereby evading degradation and are instead recycled . For example ,t?e1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] Gene_or_gene_productt5interceding-token ngrams: thereby evading degradationt!interceding-token ngrams: fail tot+interceding-token ngrams: heterodimers failt.interceding-token ngrams: heterodimers fail tot(interceding-token ngrams: to recruit Cblt(interceding-token ngrams: , heterodimerst[e1: trigger-arg-path: Positive_activation >nn [lemma='egf'] controller:Gene_or_gene_productt?e1: trigger-arg-path: stimulation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] Gene_or_gene_productt$interceding-token ngrams: sorted fortFe1: trigger-arg-path: Positive_activation >nn [lemma='egf'] controllert#interceding-token ngrams: example ,t4interceding-token ngrams: degradation , heterodimerst0CSSPATH: ROOT >advcl >prep_on ++ ROOT >nsubjpasst?e1: trigger-arg-path: stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] Gene_or_gene_producttXe2: trigger-arg-path: heterodimers:Binding >nn [lemma='egfr'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulation:Positive_activation nsubjpass [lemma='homodimer'] >nn [lemma='egfr'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erbb2'] themetBe2: trigger-arg-path: promotes >prep_with [lemma='yy1'] controllert>e2: trigger-arg-path: promotes >prep_with Gene_or_gene_productt&interceding-token ngrams: is caused byt)e2: args2Role-mention-ngram: promotes itst'interceding-token ngrams: ATMmutation .t interceding-token ngrams: causedt]e2: trigger-arg-path: lemmatizedTrigger=promote >prep_with [lemma='yy1'] Gene_or_gene_productt/interceding-token ngrams: for neurodegenerationt(interceding-token ngrams: by ATMmutationt+interceding-token ngrams: neurodegenerationt"e2: ents2Label-mention-ngram: T372tKe2: trigger-arg-path: promotes nsubj [lemma='ATM'] controllertIe2: trigger-arg-path: promotes >prep_with controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: T372 )t4e2: trigger-arg-path: promotes >prep_with controllert*e2: ents2Label-mention-ngram: at threoninetHe1: trigger-arg-path: mediated >nsubj [lemma='ATM'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_with [lemma='yy1'] controller:Gene_or_gene_producttGe2: trigger-arg-path: promotes prep_with [lemma='yy1'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_regulation >prep_with [lemma='yy1'] controller:Gene_or_gene_productt5e2: args2Role-mention-ngram: promotes its interactiont(e2: ents2Label-mention-ngram: 372 ( T372t\e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_productt1interceding-token ngrams: ataxia-telangiectasia ,t#e2: args2Role-mention-ngram: T372 )tae2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_with [lemma='yy1'] controllert/interceding-token ngrams: ataxia-telangiectasiat_e2: trigger-arg-path: promotes:Positive_regulation prep_with [lemma='yy1'] Gene_or_gene_productthe2: trigger-arg-path: promotes:Positive_regulation prep_with [lemma='yy1'] controllertxe1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] controller:Gene_or_gene_producttRe2: trigger-arg-path: promotes:Positive_regulation >prep_with Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ATM'] controllert%e2: args2Role-mention-ngram: ( T372 )t$e2: ents2Label-mention-ngram: ( T372t+e2: ents2Label-mention-ngram: threonine 372t.e2: ents2Label-mention-ngram: at threonine 372t*e2: ents2Label-mention-ngram: promotes itstWe2: trigger-arg-path: Positive_regulation >prep_with [lemma='yy1'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=promote e1: trigger-arg-path: mediated >nsubj [lemma='ATM'] controllert-e2: args2Role-mention-ngram: and promotes itsthe2: trigger-arg-path: lemmatizedTrigger=promote >prep_with [lemma='yy1'] controller:Gene_or_gene_producttVe2: trigger-arg-path: promotes:Positive_regulation >prep_with [lemma='yy1'] controllertOe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] controllertGe2: trigger-arg-path: promotes:Positive_regulation nsubj [lemma='ATM'] controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ATM'] controller:Gene_or_gene_productt%interceding-token ngrams: ATMmutationt!e2: ents2Label-mention-ngram: 372tSe1: trigger-arg-path: mediated >nsubj [lemma='ATM'] controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation prep_with controllertprep_with controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: ) and promotest!e2: args2Role-mention-ngram: T372t3e2: trigger-arg-path: promotes prep_with [lemma='yy1'] Gene_or_gene_productt'e2: args2Role-mention-ngram: T372 ) andtge2: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >prep_with [lemma='yy1'] controllertWe2: trigger-arg-path: promotes >prep_with [lemma='yy1'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=promote prep_with [lemma='yy1'] controller:Gene_or_gene_productt?interceding-tokens-full-span: is critical for neurodegeneration in ataxia-telangiectasia , which is caused by ATMmutation . Moreover ,t1e2: ents2Label-mention-ngram: SHARED at threoninet\e2: trigger-arg-path: lemmatizedTrigger=promote prep_to [lemma='Mirk'] Gene_or_gene_producttOe2: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] Gene_or_gene_producttMe2: trigger-arg-path: bind >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] Gene_or_gene_producttFe2: trigger-arg-path: bind:Binding >prep_to theme:Gene_or_gene_producttRe2: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] theme:Gene_or_gene_producttJe1: trigger-arg-path: bind >nsubj [lemma='p38'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Mirk'] Gene_or_gene_productt8e1: trigger-arg-path: Binding >nsubj [lemma='p38'] themetDe1: trigger-arg-path: bind >nsubj [lemma='p38'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt>e2: trigger-arg-path: bind >prep_to theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt@e2: trigger-arg-path: bind:Binding >prep_to Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='Mirk'] themetOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] themetDe2: trigger-arg-path: bind >nsubj [lemma='p38'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >nsubj [lemma='p38'] Gene_or_gene_producttRe1: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] theme:Gene_or_gene_productt5e1: trigger-arg-path: bind >nsubj [lemma='p38'] themetLe2: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] Gene_or_gene_productt8e2: trigger-arg-path: bind >prep_to Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] themet=e2: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] themet@e2: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] themetJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='Mirk'] themetde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] theme:Gene_or_gene_productt=e1: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] themetGe2: trigger-arg-path: Binding >nsubj [lemma='p38'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] themet\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] theme:Gene_or_gene_productt5e2: trigger-arg-path: bind >nsubj [lemma='p38'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_to [lemma='Mirk'] Gene_or_gene_producttUe2: trigger-arg-path: bind:Binding >prep_to [lemma='Mirk'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >nsubj [lemma='p38'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='p38'] theme:Gene_or_gene_producttLe1: trigger-arg-path: bind:Binding >nsubj [lemma='p38'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] Gene_or_gene_productt8e2: trigger-arg-path: bind >prep_to [lemma='Mirk'] themetGe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='p38'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='p38'] Gene_or_gene_producttGe2: trigger-arg-path: bind >prep_to [lemma='Mirk'] Gene_or_gene_producttJe2: trigger-arg-path: bind >nsubj [lemma='p38'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubj [lemma='p38'] theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding >prep_to [lemma='Mirk'] themetce1: trigger-arg-path: decreased:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: SHARED with growthtXe1: trigger-arg-path: decreased:Positive_regulation >nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER with specifict%e1: args2Role-mention-ngram: drugs ort&e1: ents2Label-mention-ngram: drugs ortte1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt}e1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productthe1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controllert+e1: ents2Label-mention-ngram: decreased thet*e1: args2Role-mention-ngram: with specifict7e1: ents2Label-mention-ngram: decreased the interactiont.e1: args2Role-mention-ngram: specific drugs ort/e1: args2Role-mention-ngram: or siRNA decreasedt?e1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of Gene_or_gene_productt:e1: trigger-arg-path: decreased >nsubj >prep_of controllert|e1: trigger-arg-path: decreased:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] Gene_or_gene_productt5e1: args2Role-mention-ngram: decreased the CONTROLLEDt1e1: ents2Label-mention-ngram: siRNA decreased thet#e1: ents2Label-mention-ngram: drugst1e1: ents2Label-mention-ngram: with specific drugst+e1: args2Role-mention-ngram: specific drugst0e1: ents2Label-mention-ngram: or siRNA decreasedt"e1: args2Role-mention-ngram: drugstDe1: trigger-arg-path: decreased >nsubj >prep_of Gene_or_gene_producttre1: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] Gene_or_gene_productt%e1: args2Role-mention-ngram: or siRNAtie1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of Gene_or_gene_productt*e1: args2Role-mention-ngram: decreased thetoe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controllert+e1: args2Role-mention-ngram: drugs or siRNAt,e1: args2Role-mention-ngram: siRNA decreasedt&e1: ents2Label-mention-ngram: or siRNAt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controllert/e1: ents2Label-mention-ngram: specific drugs ortre1: trigger-arg-path: decreased:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controllert%e1: args2Role-mention-ngram: specifict?e1: trigger-arg-path: decreased:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controller:Gene_or_gene_producttOe1: trigger-arg-path: decreased >nsubj >prep_of controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: with specifict0e1: args2Role-mention-ngram: with specific drugst0e1: args2Role-mention-ngram: siRNA decreased thet^e1: trigger-arg-path: decreased >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controllert&e1: ents2Label-mention-ngram: specifict_e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of controllerthe1: trigger-arg-path: decreased >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: specific drugstKe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >prep_of controllert2e1: ents2Label-mention-ngram: SHARED with specifict,e2: ents2Label-mention-ngram: PML and SHAREDt-e1: ents2Label-mention-ngram: siRNA decreasedtNe1: trigger-arg-path: decreased:Positive_regulation >nsubj >prep_of controllert,e1: ents2Label-mention-ngram: drugs or siRNAtse1: trigger-arg-path: decreased >nsubj [lemma='inhibition'] >prep_of [lemma='erk2'] controller:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] themetCe2: trigger-arg-path: bound:Binding >dobj >nn theme:Simple_chemicaltye2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_productt`e1: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_productt^e2: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltue1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltMe2: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetke1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themet7e1: trigger-arg-path: Binding >dobj >nn Simple_chemicaltNe1: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetse2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_productt^e2: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltNe2: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetVe1: trigger-arg-path: bound >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetbe1: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt0e1: ents2Label-mention-ngram: SHARED bound H-Rastbe2: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: A59G SHAREDthe2: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_productt.e2: args2Role-mention-ngram: THEME bound H-Rast`e2: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_producttVe2: trigger-arg-path: bound >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltbe1: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_producttTe2: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetZe2: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_productt5e1: trigger-arg-path: bound >dobj >nn Simple_chemicalt'e2: args2Role-mention-ngram: A59G THEMEt^e1: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltke2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltbe2: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_producttde2: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Simple_chemicalt;e2: trigger-arg-path: bound >dobj >nn theme:Simple_chemicalt-e2: args2Role-mention-ngram: H-Ras A59G THEMEt0e2: ents2Label-mention-ngram: SHARED bound H-RastFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn Simple_chemicalt^e1: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltZe1: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_productthe1: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_producttSe2: trigger-arg-path: bound:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themet.e1: args2Role-mention-ngram: THEME bound H-Rast/e1: ents2Label-mention-ngram: H-Ras A59G SHAREDtKe1: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetTe1: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetse1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: A59G SHAREDt\e1: trigger-arg-path: bound >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicalt;e1: trigger-arg-path: bound >dobj >nn theme:Simple_chemicaltCe1: trigger-arg-path: bound:Binding >dobj >nn theme:Simple_chemicaltqe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_productt\e2: trigger-arg-path: bound >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltXe1: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt\e1: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_productt\e2: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] Gene_or_gene_producttXe2: trigger-arg-path: Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltde1: trigger-arg-path: bound:Binding >dobj [lemma='conformer'] >nn [lemma='md'] theme:Simple_chemicaltTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn Simple_chemicaltqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Simple_chemicaltee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] themetKe2: trigger-arg-path: bound >nsubj [lemma='a'] >prep_of [lemma='GDP'] themet'e1: args2Role-mention-ngram: A59G THEMEt=e1: trigger-arg-path: Binding >dobj >nn theme:Simple_chemicalt5e2: trigger-arg-path: bound >dobj >nn Simple_chemicaltde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn Simple_chemicalt=e1: trigger-arg-path: bound:Binding >dobj >nn Simple_chemicaltTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >nn theme:Simple_chemicalt\e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetoe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltLe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >nn theme:Simple_chemicalt-e1: args2Role-mention-ngram: H-Ras A59G THEMEt=e2: trigger-arg-path: bound:Binding >dobj >nn Simple_chemicaltLe2: trigger-arg-path: bound >dobj [lemma='conformer'] >nn [lemma='md'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] themet\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetge1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt/e2: ents2Label-mention-ngram: H-Ras A59G SHAREDt7e2: trigger-arg-path: Binding >dobj >nn Simple_chemicaltoe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicalt=e2: trigger-arg-path: Binding >dobj >nn theme:Simple_chemicalt9shortest-path: dobj [lemma='conformer'] >nn [lemma='md'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themetge2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='conformer'] >nn [lemma='md'] Simple_chemicaltde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='a'] >prep_of [lemma='GDP'] themet$interceding-token ngrams: Raf1 , andtpe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt"interceding-token ngrams: the BiFCt*interceding-token ngrams: capacity betweentAe2: trigger-arg-path: affinity >prep_between [lemma='raf1'] themetSe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='raf1'] themet]e2: trigger-arg-path: affinity:Binding >prep_between [lemma='k-rasc185'] Gene_or_gene_productt"interceding-token ngrams: detect at#interceding-token ngrams: , we havet^e2: trigger-arg-path: affinity:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt2interceding-token ngrams: background level bindingtTe2: trigger-arg-path: Binding >prep_between [lemma='k-rasc185'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='k-rasc185'] themet interceding-token ngrams: detectt'interceding-token ngrams: that the BiFCtEe1: trigger-arg-path: interactions >prep_between [lemma='raf1'] themetbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] themethe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='raf1'] theme:Gene_or_gene_productt'interceding-token ngrams: have observedt%interceding-token ngrams: in that thet'interceding-token ngrams: level bindingt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] themetke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] theme:Gene_or_gene_producttUe2: trigger-arg-path: affinity >prep_between [lemma='k-rasc185'] Gene_or_gene_producttMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf1'] themetse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: affinity:Binding >prep_between [lemma='raf1'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='k-rasc185'] theme:Gene_or_gene_productt?interceding-tokens-full-span: . Moreover , we have observed in that the BiFC assay could detect a background level binding capacity between K-Ras and Raf1 , and sucht-interceding-token ngrams: detect a backgroundt[e2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='raf1'] themet2interceding-token ngrams: binding capacity betweentCe2: ents2Label-mention-ngram: affinity between GENE_OR_GENE_PRODUCTt\e1: trigger-arg-path: interactions:Binding >prep_between [lemma='k-ra'] Gene_or_gene_producttTe1: trigger-arg-path: interactions >prep_between [lemma='raf1'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_productt\e1: trigger-arg-path: interactions:Binding >prep_between [lemma='raf1'] Gene_or_gene_producttZe2: trigger-arg-path: Binding >prep_between [lemma='k-rasc185'] theme:Gene_or_gene_producttbe1: trigger-arg-path: interactions:Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttEe1: trigger-arg-path: interactions >prep_between [lemma='k-ra'] themetVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] themet,interceding-token ngrams: a background leveltNe2: trigger-arg-path: affinity:Binding >prep_between [lemma='k-rasc185'] themet$interceding-token ngrams: BiFC assayt*interceding-token ngrams: BiFC assay couldtIe2: trigger-arg-path: affinity:Binding >prep_between [lemma='raf1'] themetse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_productt0interceding-token ngrams: level binding capacitytMe1: trigger-arg-path: interactions:Binding >prep_between [lemma='k-ra'] themet%interceding-token ngrams: assay couldt$interceding-token ngrams: , and suchtPe2: trigger-arg-path: affinity >prep_between [lemma='raf1'] Gene_or_gene_producttTe1: trigger-arg-path: interactions >prep_between [lemma='k-ra'] Gene_or_gene_productt[e2: trigger-arg-path: affinity >prep_between [lemma='k-rasc185'] theme:Gene_or_gene_productt@e1: trigger-arg-path: Binding >prep_between [lemma='raf1'] themetce2: trigger-arg-path: affinity:Binding >prep_between [lemma='k-rasc185'] theme:Gene_or_gene_productt(interceding-token ngrams: could detect at,interceding-token ngrams: assay could detecttEe2: trigger-arg-path: Binding >prep_between [lemma='k-rasc185'] themetVe2: trigger-arg-path: affinity >prep_between [lemma='raf1'] theme:Gene_or_gene_productt*interceding-token ngrams: have observed int*interceding-token ngrams: we have observedtXe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='k-rasc185'] themet*interceding-token ngrams: observed in thattge2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='k-rasc185'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='k-ra'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='k-rasc185'] Gene_or_gene_producttZe1: trigger-arg-path: interactions >prep_between [lemma='raf1'] theme:Gene_or_gene_productt$interceding-token ngrams: backgroundt$interceding-token ngrams: and Raf1 ,t&interceding-token ngrams: a backgroundt"interceding-token ngrams: and sucht:CSSPATH: ROOT >prep_with >prep_on ++ ROOT >conj_and >nsubjt(interceding-token ngrams: the BiFC assaytje2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='raf1'] Gene_or_gene_productt0interceding-token ngrams: capacity between K-Rast@e1: trigger-arg-path: Binding >prep_between [lemma='k-ra'] themetue2: trigger-arg-path: lemmatizedTrigger=affinity:Binding >prep_between [lemma='k-rasc185'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] Gene_or_gene_productt*interceding-token ngrams: background leveltbe2: trigger-arg-path: lemmatizedTrigger=affinity >prep_between [lemma='raf1'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='raf1'] Gene_or_gene_producttFe2: trigger-arg-path: affinity >prep_between [lemma='k-rasc185'] themetOe1: trigger-arg-path: Binding >prep_between [lemma='k-ra'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='k-ra'] Gene_or_gene_productt interceding-token ngrams: Raf1 ,t&interceding-token ngrams: could detectt^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='raf1'] themet!interceding-token ngrams: we havetZe1: trigger-arg-path: interactions >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_between [lemma='raf1'] Gene_or_gene_productt7e1: trigger-arg-path: complex >nn [lemma='itsn1'] themetNe1: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] Gene_or_gene_producttTe1: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttIe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] themetLe1: trigger-arg-path: complex >nn [lemma='itsn1'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] theme:Gene_or_gene_producttFe1: trigger-arg-path: complex >nn [lemma='itsn1'] Gene_or_gene_productt?e1: trigger-arg-path: complex:Binding >nn [lemma='itsn1'] themetXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='itsn1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='itsn1'] themetce2: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_of [lemma='nleh1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themetYe2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] themet=e2: ents2Label-mention-ngram: Binding of GENE_OR_GENE_PRODUCTtDinterceding-tokens-full-span: independent of their kinase activity .tce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_productt+CSSPATH: ROOT >prep_of >amod ++ ROOT >nsubjtke2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] themetue2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_of [lemma='nleh1'] theme:Gene_or_gene_productt\e2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themetprep_of [lemma='nleh1'] themet]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='nleh1'] Gene_or_gene_producttie2: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themet}e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] themetqe2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] >prep_to [lemma='rps3'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] Gene_or_gene_producttDe2: trigger-arg-path: Binding:Binding >prep_of [lemma='nleh1'] themet#interceding-token ngrams: . We thust_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt)interceding-token ngrams: thus determinedtSe2: trigger-arg-path: formed a complex nsubj theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj themetse2: trigger-arg-path: formed a complex prep_with [lemma='hdac1'] themete2: trigger-arg-path: Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with Gene_or_gene_productt%e2: args2Role-mention-ngram: formed at9e2: trigger-arg-path: Binding prep_with themetwinterceding-tokens-full-span: to regulate RECK expression via the Sp1 site of the promoter . We thus determined whethert+e2: args2Role-mention-ngram: THEME formed at(e1: ents2Label-mention-ngram: binds withtBe1: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] themetPe1: trigger-arg-path: Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_producttpe2: trigger-arg-path: formed a complex nsubj [lemma='rbap46'] themetWe1: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] Gene_or_gene_productt>e2: trigger-arg-path: formed a complex nsubj themet?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] themet-e2: args2Role-mention-ngram: formed a complextUe2: trigger-arg-path: formed a complex:Binding nsubj Gene_or_gene_productt,interceding-token ngrams: We thus determinedtinterceding-token ngrams: RECKtoe2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] themet,e1: args2Role-mention-ngram: then binds witht=e1: ents2Label-mention-ngram: binds with GENE_OR_GENE_PRODUCTt'e1: args2Role-mention-ngram: binds witht&e2: ents2Label-mention-ngram: formed at|e2: trigger-arg-path: Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_productt,interceding-token ngrams: determined whethertFe2: trigger-arg-path: formed a complex:Binding nsubj themetMe2: trigger-arg-path: formed a complex nsubj Gene_or_gene_productt?e2: trigger-arg-path: formed a complex prep_with [lemma='hdac1'] theme:Gene_or_gene_productt%interceding-token ngrams: via the Sp1t"e1: args2Role-mention-ngram: HDAC1tRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] themetNe2: trigger-arg-path: Binding prep_with theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: HDAC1 and thent-e1: args2Role-mention-ngram: binds with THEMEtBe2: trigger-arg-path: formed a complex prep_with themete2: trigger-arg-path: formed a complex nsubj [lemma='rbap46'] Gene_or_gene_productt+e1: args2Role-mention-ngram: and then bindst?e2: trigger-arg-path: formed a complex:Binding nsubj [lemma='rbap46'] Gene_or_gene_productt&interceding-token ngrams: the Sp1 sitet?e2: trigger-arg-path: formed a complex:Binding prep_with [lemma='hdac1'] Gene_or_gene_productt(interceding-token ngrams: expression viat?e2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] theme:Gene_or_gene_productt'e1: args2Role-mention-ngram: with HDAC1t&e1: args2Role-mention-ngram: HDAC1 andtPe1: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: formedtJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] themet?e2: trigger-arg-path: formed a complex nsubj [lemma='rbap46'] theme:Gene_or_gene_productt!interceding-token ngrams: the Sp1t[e2: trigger-arg-path: formed a complex:Binding nsubj theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] Gene_or_gene_producttprep_with [lemma='sp1'] themetRe2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with themetge2: trigger-arg-path: Binding nsubj [lemma='rbap46'] themet:e1: trigger-arg-path: binds >prep_with [lemma='sp1'] themete2: trigger: formed a complext2interceding-token ngrams: regulate RECK expressiont?e2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] themetIe1: trigger-arg-path: binds >prep_with [lemma='sp1'] Gene_or_gene_producttQe2: trigger-arg-path: formed a complex prep_with Gene_or_gene_producttye2: trigger-arg-path: Binding prep_with [lemma='hdac1'] Gene_or_gene_productt5e2: trigger-arg-path: Binding nsubj themet+e1: args2Role-mention-ngram: with HDAC1 andt,interceding-token ngrams: expression via thetQe1: trigger-arg-path: binds:Binding >prep_with [lemma='sp1'] Gene_or_gene_producttve2: trigger-arg-path: Binding nsubj [lemma='rbap46'] Gene_or_gene_productt%interceding-token ngrams: site of thet-interceding-token ngrams: RECK expression viat%interceding-token ngrams: Sp1 site oft?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] themet'interceding-token ngrams: promoter . WetNe2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj themetee2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >nsubj [lemma='rbap46'] themetVe1: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt{e2: trigger-arg-path: formed a complex:Binding prep_with [lemma='hdac1'] themet*interceding-token ngrams: to regulate RECKt?e2: ents2Label-mention-ngram: complex with GENE_OR_GENE_PRODUCTt'interceding-token ngrams: regulate RECKthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: formedtKe1: trigger-arg-path: Binding >prep_with [lemma='sp1'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >nsubj [lemma='rbap46'] themet?e2: trigger-arg-path: formed a complex prep_with [lemma='hdac1'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_with [lemma='sp1'] Gene_or_gene_producttQe1: trigger-arg-path: Binding >prep_with [lemma='sp1'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: complex with THEMEt?e2: trigger-arg-path: formed a complex:Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: then binds witht?e2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with [lemma='hdac1'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: HDAC1 and thent)interceding-token ngrams: of the promotert,e1: ents2Label-mention-ngram: and then bindstWe2: trigger-arg-path: formed a complex prep_with theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] themetae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] Gene_or_gene_producttje2: trigger-arg-path: Binding prep_with [lemma='hdac1'] themet?e2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] theme:Gene_or_gene_productt!interceding-token ngrams: We thustDe2: trigger-arg-path: Binding nsubj Gene_or_gene_productt+e2: ents2Label-mention-ngram: SHARED formedtge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with [lemma='hdac1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: formed a complex:Binding prep_with Gene_or_gene_producttJe1: trigger-arg-path: Binding >nsubj [lemma='rbap46'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj [lemma='rbap46'] Gene_or_gene_productt!interceding-token ngrams: site oft]e2: trigger-arg-path: lemmatizedTrigger=form a complex nsubj Gene_or_gene_productt1interceding-token ngrams: thus determined whethertJe2: trigger-arg-path: Binding nsubj theme:Gene_or_gene_producttHe2: trigger-arg-path: Binding prep_with Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with Gene_or_gene_producttxe2: trigger-arg-path: formed a complex:Binding nsubj [lemma='rbap46'] themet-e2: ents2Label-mention-ngram: SHARED formed atHe1: trigger-arg-path: binds >nsubj [lemma='rbap46'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] themet.e2: ents2Label-mention-ngram: formed a complext/e1: args2Role-mention-ngram: complex with HDAC1t_e2: trigger-arg-path: formed a complex:Binding prep_with theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind >prep_with [lemma='sp1'] theme:Gene_or_gene_productt)interceding-token ngrams: RECK expressiont?e2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=form a complex:Binding prep_with themet(interceding-token ngrams: the promoter .t9e1: trigger-arg-path: binds >nsubj [lemma='rbap46'] themet?e2: trigger-arg-path: formed a complex:Binding nsubj [lemma='rbap46'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=form a complex prep_with theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: THEME formedtJe2: trigger-arg-path: formed a complex:Binding prep_with themetYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbap46'] Gene_or_gene_productt"interceding-token ngrams: Sp1 sitetOe1: trigger-arg-path: binds >prep_with [lemma='sp1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds >nsubj [lemma='rbap46'] theme:Gene_or_gene_productt2interceding-token ngrams: , co-immunoprecipitationt(CSSPATH: ROOT  ++ ROOT >ccomp >nsubjpassthe1: trigger-arg-path: increased >agent [lemma='shrna'] >nn [lemma='ogt'] controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='e-cadherin'] themet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controller:Gene_or_gene_producttfe2: trigger-arg-path: interaction:Binding >prep_with [lemma='beta-catenin'] theme:Gene_or_gene_producttCe1: trigger-arg-path: increased >nsubjpass >nn Gene_or_gene_productt,e1: ents2Label-mention-ngram: expression wast*interceding-token ngrams: it was decreasedt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlled:Gene_or_gene_productt,interceding-token ngrams: experiments showedtOe2: trigger-arg-path: interaction >nn [lemma='e-cadherin'] Gene_or_gene_productt@e2: trigger-arg-path: interaction >nn [lemma='e-cadherin'] themetoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='e-cadherin'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: protein expression wast"interceding-token ngrams: NButGT .tce2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='beta-catenin'] themetge2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='e-cadherin'] theme:Gene_or_gene_productt`e2: trigger-arg-path: interaction:Binding >prep_with [lemma='beta-catenin'] Gene_or_gene_productt?e1: trigger-arg-path: increased >agent >nn Gene_or_gene_producttQe2: trigger-arg-path: Binding >nn [lemma='e-cadherin'] theme:Gene_or_gene_productt interceding-token ngrams: NButGTtMe1: trigger-arg-path: increased:Positive_activation >nsubjpass >nn controlledtIe2: trigger-arg-path: interaction >prep_with [lemma='beta-catenin'] themet[e2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='beta-catenin'] themet0interceding-token ngrams: decreased by treatmenttZe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent >nn controllert&interceding-token ngrams: and NButGT .the1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass >nn Gene_or_gene_productt4e1: ents2Label-mention-ngram: protein expression wastFe1: trigger-arg-path: lemmatizedTrigger=increase >agent >nn controllert+interceding-token ngrams: PUGNAc and NButGTtJe1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass >nn controlledtje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='beta-catenin'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: protein expressiontpe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='beta-catenin'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: protein expressiontxe1: trigger-arg-path: increased >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlled:Gene_or_gene_producttZe2: trigger-arg-path: Binding >prep_with [lemma='beta-catenin'] theme:Gene_or_gene_productt-interceding-token ngrams: the pharmacologicalt:e1: args2Role-mention-ngram: CONTROLLED protein expressiont]e1: trigger-arg-path: Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controllert1interceding-token ngrams: experiments showed thattae2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='e-cadherin'] Gene_or_gene_productt,interceding-token ngrams: treatment with thetQe2: trigger-arg-path: interaction:Binding >prep_with [lemma='beta-catenin'] themet^e1: trigger-arg-path: increased:Positive_activation >agent >nn controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: SHARED protein expressiont^e2: trigger-arg-path: interaction >prep_with [lemma='beta-catenin'] theme:Gene_or_gene_producttce1: trigger-arg-path: increased >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlledtte1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlledtde1: trigger-arg-path: lemmatizedTrigger=increase >agent [lemma='shrna'] >nn [lemma='ogt'] controllertIe1: trigger-arg-path: increased:Positive_activation >agent >nn controllert1interceding-token ngrams: the pharmacological OGAt?e1: trigger-arg-path: increased:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlled:Gene_or_gene_productt%interceding-token ngrams: experimentst*interceding-token ngrams: was decreased byt;interceding-token ngrams: Moreover , co-immunoprecipitationt9e1: trigger-arg-path: increased >nsubjpass >nn controlledt?interceding-tokens-full-span: shRNA , while it was decreased by treatment with the pharmacological OGA inhibitors PUGNAc and NButGT . Moreover , co-immunoprecipitation experiments showed thattnn [lemma='e-cadherin'] themet]e2: trigger-arg-path: interaction:Binding >nn [lemma='e-cadherin'] theme:Gene_or_gene_producttWe1: trigger-arg-path: increased:Positive_activation >nsubjpass >nn Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: increased:Positive_activation >agent >nn Gene_or_gene_producttge1: trigger-arg-path: increased:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controllert.e1: ents2Label-mention-ngram: was increased byt5e1: trigger-arg-path: increased >agent >nn controllertJe1: trigger-arg-path: increased >agent >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlled:Gene_or_gene_productt!interceding-token ngrams: shRNA ,t?e1: trigger-arg-path: increased:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='beta-catenin'] theme:Gene_or_gene_producttWe2: trigger-arg-path: interaction:Binding >nn [lemma='e-cadherin'] Gene_or_gene_producttEe2: trigger-arg-path: Binding >prep_with [lemma='beta-catenin'] themetge1: trigger-arg-path: Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] Gene_or_gene_productt/interceding-token ngrams: inhibitors PUGNAc andt*e1: ents2Label-mention-ngram: increased bytre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='beta-catenin'] Gene_or_gene_productt'interceding-token ngrams: was decreasedt interceding-token ngrams: it wast-interceding-token ngrams: pharmacological OGAt(interceding-token ngrams: OGA inhibitorstTe2: trigger-arg-path: Binding >prep_with [lemma='beta-catenin'] Gene_or_gene_productt|e1: trigger-arg-path: increased:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controller:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass >nn Gene_or_gene_productt+interceding-token ngrams: inhibitors PUGNActme1: trigger-arg-path: Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlledt+e1: ents2Label-mention-ngram: was increasedtme1: trigger-arg-path: increased >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] Gene_or_gene_productt?e1: ents2Label-mention-ngram: increased by GENE_OR_GENE_PRODUCTtoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent >nn controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] Gene_or_gene_productt-e1: args2Role-mention-ngram: was increased bytwe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLED proteintCinterceding-token ngrams: co-immunoprecipitation experiments showedtye1: trigger-arg-path: lemmatizedTrigger=increase >agent [lemma='shrna'] >nn [lemma='ogt'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: expression wastSe1: trigger-arg-path: increased >agent [lemma='shrna'] >nn [lemma='ogt'] controllertKe2: trigger-arg-path: Binding >nn [lemma='e-cadherin'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: expression was increasedt&interceding-token ngrams: decreased byt^e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass >nn controlledtUe2: trigger-arg-path: interaction >nn [lemma='e-cadherin'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=increase >agent >nn Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=increase >nsubjpass >nn controlled:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controllertinterceding-token ngrams: OGAt4e1: args2Role-mention-ngram: increased by CONTROLLERtbe1: trigger-arg-path: increased:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] Gene_or_gene_productt/interceding-token ngrams: OGA inhibitors PUGNActse1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubjpass >nn controlled:Gene_or_gene_productt0interceding-token ngrams: co-immunoprecipitationt5e1: args2Role-mention-ngram: expression was increasedt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] Gene_or_gene_productt$interceding-token ngrams: , while ittie2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='e-cadherin'] Gene_or_gene_productt interceding-token ngrams: PUGNActwe1: trigger-arg-path: increased:Positive_activation >nsubjpass [lemma='expression'] >nn [lemma='e-cadherin'] controlledtne1: trigger-arg-path: lemmatizedTrigger=increase >agent [lemma='shrna'] >nn [lemma='ogt'] Gene_or_gene_producttXe2: trigger-arg-path: interaction >prep_with [lemma='beta-catenin'] Gene_or_gene_productt+interceding-token ngrams: NButGT . Moreovert$interceding-token ngrams: and NButGTt+interceding-token ngrams: by treatment witht]e1: trigger-arg-path: increased >agent [lemma='shrna'] >nn [lemma='ogt'] Gene_or_gene_productt&interceding-token ngrams: while it wastRe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='e-cadherin'] themetNe1: trigger-arg-path: increased >nsubjpass >nn controlled:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >agent >nn Gene_or_gene_producttHe2: trigger-arg-path: interaction:Binding >nn [lemma='e-cadherin'] themetqe1: trigger-arg-path: increased:Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] Gene_or_gene_productt8interceding-token ngrams: pharmacological OGA inhibitorstre1: trigger-arg-path: Positive_activation >agent [lemma='shrna'] >nn [lemma='ogt'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: was increasedt>interceding-token ngrams: , co-immunoprecipitation experimentst"interceding-token ngrams: while itt'interceding-token ngrams: shRNA , whilet[e1: trigger-arg-path: lemmatizedTrigger=increase >agent >nn controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: increased byt2interceding-token ngrams: with the pharmacologicalt$interceding-token ngrams: PUGNAc andt"interceding-token ngrams: upon EGFt:e2: trigger-arg-path: immunoprecipitated >nsubjpass Familytze2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] themetNe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with >nn themet'e2: args2Role-mention-ngram: or withoutt8e2: args2Role-mention-ngram: was immunoprecipitated witht$e2: args2Role-mention-ngram: withouttee2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with >nn Gene_or_gene_producttie2: trigger-arg-path: immunoprecipitated:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] themethe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without >nn Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='aspp2'] themet@e2: trigger-arg-path: immunoprecipitated >nsubjpass theme:Familyt5e2: trigger-arg-path: Binding >nsubjpass theme:FamilytEe2: trigger-arg-path: immunoprecipitated:Binding >prep_with >nn themetRe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass themet?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttFe2: trigger-arg-path: immunoprecipitated >nsubjpass [lemma='ra'] themethe2: trigger-arg-path: Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: without SHAREDtNe1: trigger-arg-path: Binding >dobj [lemma='aspp2'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass Familytye2: trigger-arg-path: immunoprecipitated >prep_without [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttee2: trigger-arg-path: Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with >nn theme:Gene_or_gene_productt?e2: trigger-arg-path: immunoprecipitated:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] themet8e2: ents2Label-mention-ngram: immunoprecipitated with ortVe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with >nn themet9e2: trigger-arg-path: immunoprecipitated >nsubjpass themet;e2: trigger-arg-path: Binding >nsubjpass [lemma='ra'] themet/e2: trigger-arg-path: Binding >nsubjpass FamilytHe1: trigger-arg-path: Binding >dobj [lemma='aspp2'] Gene_or_gene_producttUe2: trigger-arg-path: immunoprecipitated >prep_without >nn theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: was immunoprecipitatedtMe2: trigger-arg-path: immunoprecipitated >nsubjpass [lemma='ra'] theme:Familyt+interceding-token ngrams: EGF stimulation .t?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttse2: trigger-arg-path: immunoprecipitated >prep_without [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass [lemma='ra'] Familytde2: trigger-arg-path: immunoprecipitated >prep_without [lemma='induction'] >nn [lemma='aspp2'] themet?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttLe2: trigger-arg-path: immunoprecipitated >prep_with >nn Gene_or_gene_producttNe1: trigger-arg-path: binds:Binding >dobj [lemma='aspp2'] Gene_or_gene_producttae2: trigger-arg-path: immunoprecipitated >prep_with [lemma='induction'] >nn [lemma='aspp2'] themetJe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass themetHe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass theme:Familyt.interceding-token ngrams: upon EGF stimulationtfe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without >nn theme:Gene_or_gene_producttve2: trigger-arg-path: immunoprecipitated >prep_with [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass theme:FamilytQe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass theme:Familyt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='aspp2'] Gene_or_gene_producttDe2: trigger-arg-path: Binding >prep_without >nn Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with >nn theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='aspp2'] themetxe2: trigger-arg-path: immunoprecipitated:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_productt5e2: trigger-arg-path: Binding >prep_without >nn themetBe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass Familyt9e2: args2Role-mention-ngram: THEME was immunoprecipitatedt@e2: trigger-arg-path: immunoprecipitated >prep_without >nn themetBe2: trigger-arg-path: Binding >nsubjpass [lemma='ra'] theme:Familyt_e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass [lemma='ra'] themetUe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass [lemma='ra'] theme:Familyt7e1: trigger-arg-path: binds >dobj [lemma='aspp2'] themetZe2: trigger-arg-path: immunoprecipitated:Binding >prep_with >nn theme:Gene_or_gene_productt%e2: ents2Label-mention-ngram: with ort7e2: args2Role-mention-ngram: immunoprecipitated with ort?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_without >nn theme:Gene_or_gene_productt=e2: trigger-arg-path: immunoprecipitated >prep_with >nn themet-e2: ents2Label-mention-ngram: with or withouttOe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass [lemma='ra'] FamilytXe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass [lemma='ra'] FamilytWe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass [lemma='ra'] themet&interceding-token ngrams: . Endogenoust(interceding-token ngrams: with differenttFe1: trigger-arg-path: binds >dobj [lemma='aspp2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttke2: trigger-arg-path: Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttGe2: trigger-arg-path: immunoprecipitated >nsubjpass [lemma='ra'] FamilytAe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass themet9e1: trigger-arg-path: Binding >dobj [lemma='aspp2'] themetfe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass [lemma='ra'] theme:Familyt~e2: trigger-arg-path: immunoprecipitated:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_productte2: trigger: immunoprecipitatedt,e2: args2Role-mention-ngram: with or withoutt/e2: ents2Label-mention-ngram: or without SHAREDtYinterceding-tokens-full-span: with different efficiency upon EGF stimulation . Endogenoust3interceding-token ngrams: with different efficiencytWe2: trigger-arg-path: immunoprecipitated:Binding >prep_without >nn Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >nsubjpass Familyt^e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >nsubjpass [lemma='ra'] theme:Familytle2: trigger-arg-path: immunoprecipitated:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] themetYe2: trigger-arg-path: Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] themet9e2: ents2Label-mention-ngram: was immunoprecipitated witht$CSSPATH: ROOT >xcomp >ccomp ++ ROOT t$e2: args2Role-mention-ngram: with ort$interceding-token ngrams: efficiencyt%e2: ents2Label-mention-ngram: withoutt?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_productt4e2: args2Role-mention-ngram: immunoprecipitated witht$interceding-token ngrams: EndogenoustRe2: trigger-arg-path: immunoprecipitated >prep_with >nn theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='aspp2'] theme:Gene_or_gene_productt3e2: args2Role-mention-ngram: was immunoprecipitatedtre2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with [lemma='induction'] >nn [lemma='aspp2'] themet?e1: trigger-arg-path: binds:Binding >dobj [lemma='aspp2'] themetOe2: trigger-arg-path: immunoprecipitated >prep_without >nn Gene_or_gene_productt*e2: args2Role-mention-ngram: without THEMEt/e2: args2Role-mention-ngram: immunoprecipitatedtue2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without [lemma='induction'] >nn [lemma='aspp2'] themetHe2: trigger-arg-path: immunoprecipitated:Binding >prep_without >nn themetpe2: trigger-arg-path: immunoprecipitated >prep_with [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='aspp2'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without >nn themet2interceding-token ngrams: stimulation . EndogenoustLe1: trigger-arg-path: binds >dobj [lemma='aspp2'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without >nn Gene_or_gene_productt3interceding-token ngrams: different efficiency upontNe2: trigger-arg-path: immunoprecipitated:Binding >nsubjpass [lemma='ra'] themetTe1: trigger-arg-path: binds:Binding >dobj [lemma='aspp2'] theme:Gene_or_gene_productt{e2: trigger-arg-path: immunoprecipitated:Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_without >nn themetne2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate:Binding >prep_without >nn theme:Gene_or_gene_producttnsubjpass [lemma='ra'] Familyt]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='aspp2'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: immunoprecipitatedt.interceding-token ngrams: different efficiencytne2: trigger-arg-path: Binding >prep_without [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_producttTe2: trigger-arg-path: immunoprecipitated:Binding >prep_with >nn Gene_or_gene_productt]e2: trigger-arg-path: immunoprecipitated:Binding >prep_without >nn theme:Gene_or_gene_productt;e2: ents2Label-mention-ngram: SHARED was immunoprecipitatedt)interceding-token ngrams: efficiency upont(e2: ents2Label-mention-ngram: or withoutt?e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with [lemma='induction'] >nn [lemma='aspp2'] theme:Gene_or_gene_productt-interceding-token ngrams: efficiency upon EGFtVe2: trigger-arg-path: Binding >prep_with [lemma='induction'] >nn [lemma='aspp2'] themet5e2: ents2Label-mention-ngram: immunoprecipitated witht-e2: args2Role-mention-ngram: or without THEMEt]e2: trigger-arg-path: lemmatizedTrigger=immunoprecipitate >prep_with >nn Gene_or_gene_productt2interceding-token ngrams: in transcription coupledt%interceding-token ngrams: radiation ,t%e2: ents2Label-mention-ngram: 1465 oft/e2: ents2Label-mention-ngram: within the LXXLAPt|e1: trigger-arg-path: Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] Gene_or_gene_producttre1: trigger-arg-path: Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controllert"interceding-token ngrams: may havetle2: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='phd1'] controller:Gene_or_gene_producttWe2: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='phd1'] controllertJe1: ents2Label-mention-ngram: hyperphosphorylation of GENE_OR_GENE_PRODUCTt#interceding-token ngrams: that Rpb1t3interceding-token ngrams: transcription coupled DNAtinterceding-token ngrams: by UVt?e1: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='phd1'] controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: hydroxylated mainly byt*e2: ents2Label-mention-ngram: proline 1465t1e2: args2Role-mention-ngram: mainly by CONTROLLERt]e2: trigger-arg-path: hydroxylated:Positive_regulation >agent controller:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='phd1'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent controllert1interceding-token ngrams: Rpb1 ubiquitination mayt-e2: ents2Label-mention-ngram: is hydroxylatedt,interceding-token ngrams: coupled DNA repairt1interceding-token ngrams: ubiquitination may havetWe1: trigger-arg-path: enhanced:Positive_regulation >agent >prep_of Gene_or_gene_productt>e2: trigger-arg-path: hydroxylated >agent Gene_or_gene_productt+interceding-token ngrams: radiation , whicht?e1: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] Gene_or_gene_productt2interceding-token ngrams: that Rpb1 ubiquitinationtTe2: trigger-arg-path: Positive_regulation >agent [lemma='phd1'] Gene_or_gene_productt4e2: trigger-arg-path: hydroxylated >agent controllert/e2: ents2Label-mention-ngram: , is hydroxylatedt$interceding-token ngrams: may have atXe2: trigger-arg-path: hydroxylated >agent [lemma='phd1'] controller:Gene_or_gene_productt?e1: args2Role-mention-ngram: hyperphosphorylation of CONTROLLERtge1: trigger-arg-path: enhanced >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controllertDe1: trigger-arg-path: Positive_regulation >agent >prep_of controllert0e1: ents2Label-mention-ngram: SHARED is enhancedt.interceding-token ngrams: Further study showedt+interceding-token ngrams: , which indicatest-interceding-token ngrams: indicates that Rpb1t?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controller:Gene_or_gene_productt-interceding-token ngrams: Rpb1 ubiquitinationtTe1: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_of Gene_or_gene_productt,e1: ents2Label-mention-ngram: is enhanced byt{e1: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controllert2e1: ents2Label-mention-ngram: hyperphosphorylationtMe2: trigger-arg-path: hydroxylated >agent [lemma='phd1'] Gene_or_gene_producttYe1: trigger-arg-path: Positive_regulation >agent >prep_of controller:Gene_or_gene_productt%interceding-token ngrams: coupled DNAt.e2: ents2Label-mention-ngram: the LXXLAP motift.e2: args2Role-mention-ngram: CONTROLLED mainlytne2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: 1465 of SHAREDt-e2: ents2Label-mention-ngram: proline 1465 oft5e1: ents2Label-mention-ngram: hyperphosphorylation oftTe2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent [lemma='phd1'] controllertre2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='phd1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: hydroxylatedt)e1: ents2Label-mention-ngram: is enhancedtJe1: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_of controllert*interceding-token ngrams: repair . FurthertRe2: trigger-arg-path: hydroxylated:Positive_regulation >agent Gene_or_gene_productt interceding-token ngrams: have atCe1: trigger-arg-path: enhanced >agent >prep_of Gene_or_gene_productt*e2: ents2Label-mention-ngram: LXXLAP motift,e2: ents2Label-mention-ngram: located withint)interceding-token ngrams: . Further studytHe2: trigger-arg-path: hydroxylated:Positive_regulation >agent controllert5e1: ents2Label-mention-ngram: by hyperphosphorylationtNe1: trigger-arg-path: Positive_regulation >agent >prep_of Gene_or_gene_productt)e1: ents2Label-mention-ngram: enhanced byt(e2: ents2Label-mention-ngram: within thet?e1: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] Gene_or_gene_productt interceding-token ngrams: repairt7e1: args2Role-mention-ngram: by hyperphosphorylation ofte2: trigger: hydroxylatedt$interceding-token ngrams: DNA repairtNe1: trigger-arg-path: enhanced >agent >prep_of controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: which is locatedt)interceding-token ngrams: which indicatest?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: is locatedtCe2: trigger-arg-path: hydroxylated >agent [lemma='phd1'] controllert1e1: args2Role-mention-ngram: hyperphosphorylationt,interceding-token ngrams: ubiquitination mayt?interceding-tokens-full-span: by UV radiation , which indicates that Rpb1 ubiquitination may have a role in transcription coupled DNA repair . Further study showed thattbe1: trigger-arg-path: enhanced:Positive_regulation >agent >prep_of controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent Gene_or_gene_productt.interceding-token ngrams: which indicates thatt%interceding-token ngrams: have a rolet%e2: ents2Label-mention-ngram: motif ,t&interceding-token ngrams: UV radiationt4e2: ents2Label-mention-ngram: is hydroxylated mainlyt(e1: args2Role-mention-ngram: is enhancedtMe1: trigger-arg-path: enhanced:Positive_regulation >agent >prep_of controllert(e2: ents2Label-mention-ngram: the LXXLAPtqe1: trigger-arg-path: enhanced >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] Gene_or_gene_productt'interceding-token ngrams: Further studyt/e2: ents2Label-mention-ngram: is located withintIe2: trigger-arg-path: hydroxylated >agent controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: mainlythe2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='phd1'] controllerthe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent >prep_of Gene_or_gene_productt9e1: trigger-arg-path: enhanced >agent >prep_of controllert|e1: trigger-arg-path: enhanced >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controller:Gene_or_gene_productt"interceding-token ngrams: repair .t)interceding-token ngrams: by UV radiationt#interceding-token ngrams: a role int?e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controllert+e1: ents2Label-mention-ngram: and SHARED ist4e1: args2Role-mention-ngram: by hyperphosphorylationt,e2: ents2Label-mention-ngram: LXXLAP motif ,tZe2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent controller:Gene_or_gene_productt=e1: args2Role-mention-ngram: enhanced by hyperphosphorylationt(e1: args2Role-mention-ngram: enhanced byt?e1: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controller:Gene_or_gene_productt+e1: args2Role-mention-ngram: is enhanced byt%e2: ents2Label-mention-ngram: prolinet"e2: ents2Label-mention-ngram: , istae2: trigger-arg-path: hydroxylated:Positive_regulation >agent [lemma='phd1'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: by hyperphosphorylation oft*interceding-token ngrams: in transcriptiont?e1: trigger-arg-path: Positive_regulation >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: locatedt$e2: ents2Label-mention-ngram: LXXLAPt$e2: ents2Label-mention-ngram: withint0e2: ents2Label-mention-ngram: located within thet&interceding-token ngrams: DNA repair .t1e2: args2Role-mention-ngram: CONTROLLED mainly byt(interceding-token ngrams: UV radiation ,t1e2: ents2Label-mention-ngram: hydroxylated mainlyt/interceding-token ngrams: role in transcriptiontxe1: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='hyperphosphorylation'] >prep_of [lemma='rpb1'] controllert'e2: ents2Label-mention-ngram: mainly byt&e2: args2Role-mention-ngram: mainly byt_e1: trigger-arg-path: lemmatizedTrigger=enhance >agent >prep_of controller:Gene_or_gene_productt>e1: ents2Label-mention-ngram: enhanced by hyperphosphorylationtagent >prep_of controllert#e2: args2Role-mention-ngram: mainlyt4e1: args2Role-mention-ngram: hyperphosphorylation oft_e2: trigger-arg-path: Positive_regulation >agent [lemma='phd1'] controller:Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >agent [lemma='phd1'] controllert!interceding-token ngrams: coupledtinterceding-token ngrams: Rpb1t"e2: ents2Label-mention-ngram: 1465t}e2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent [lemma='phd1'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: CONTROLLED is enhancedtce2: trigger-arg-path: lemmatizedTrigger=hydroxylate:Positive_regulation >agent Gene_or_gene_productt/interceding-token ngrams: transcription coupledtinterceding-token ngrams: UVtse1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent >prep_of controller:Gene_or_gene_producttEe2: trigger-arg-path: lemmatizedTrigger=hydroxylate >agent controllert#interceding-token ngrams: . Dmp1 ist6interceding-tokens-full-span: . Dmp1 is unique in thatt CSSPATH: ROOT  ++ ROOT >prepc_int!interceding-token ngrams: Dmp1 ist(interceding-token ngrams: Dmp1 is uniquet'interceding-token ngrams: maintenance 1tde2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >poss Gene_or_gene_producttdobj >poss Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=promote >dobj >poss controlledtAe1: args2Role-mention-ngram: CONTROLLER -mediated phosphorylationt'interceding-token ngrams: By contrast ,tne2: trigger-arg-path: Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] Gene_or_gene_productt\e1: trigger-arg-path: induces:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttnsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: phosphorylation inducestZe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >poss controlledt?e1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controller:Gene_or_gene_producttIe2: trigger-arg-path: promotes:Positive_activation >dobj >poss controlledt5e2: trigger-arg-path: promotes >dobj >poss controlledtce2: trigger-arg-path: promotes >dobj [lemma='presence'] >poss [lemma='snail1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='presence'] >poss [lemma='snail1'] controlledtde2: trigger-arg-path: Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlledt)interceding-token ngrams: maintenance 1 (t.e1: ents2Label-mention-ngram: to the cytoplasmtme2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlledt,interceding-token ngrams: region maintenancet&e1: args2Role-mention-ngram: -mediatedtwe1: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] Gene_or_gene_producttSe2: trigger-arg-path: promotes:Positive_activation >dobj >poss Gene_or_gene_producttge2: trigger-arg-path: promotes >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] Gene_or_gene_producttre2: trigger-arg-path: promotes >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controller:Gene_or_gene_producttye2: trigger-arg-path: Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlled:Gene_or_gene_producttre2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] Gene_or_gene_productt+interceding-token ngrams: chromosome regiont?e1: args2Role-mention-ngram: phosphorylation induces CONTROLLEDt+interceding-token ngrams: exportins such ast?e2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: cytoplasmte1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] Gene_or_gene_producttUe2: trigger-arg-path: Positive_activation >dobj >poss controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controllertve1: trigger-arg-path: induces >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controller:Gene_or_gene_producttke1: trigger-arg-path: induces >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] Gene_or_gene_productt+interceding-token ngrams: through exportinsthe2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED 'st%interceding-token ngrams: maintenancetinterceding-token ngrams: CRM1t?e2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlled:Gene_or_gene_productt1e1: args2Role-mention-ngram: CONTROLLER -mediatedtQe1: trigger-arg-path: induces:Positive_regulation >nsubj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlled:Gene_or_gene_productt'interceding-token ngrams: as chromosometJe2: trigger-arg-path: promotes >dobj >poss controlled:Gene_or_gene_productt@e2: args2Role-mention-ngram: CONTROLLER phosphorylation promotest!CSSPATH: ROOT >dobj >dep ++ ROOT t"interceding-token ngrams: ( CRM1 )t%interceding-token ngrams: By contrastt@e2: args2Role-mention-ngram: phosphorylation promotes CONTROLLEDtne2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controllert/e1: ents2Label-mention-ngram: induces SHARED 'st6e1: args2Role-mention-ngram: -mediated phosphorylationt*e1: ents2Label-mention-ngram: 's export tot'e1: ents2Label-mention-ngram: -mediatedt=e2: ents2Label-mention-ngram: phosphorylation promotes SHAREDt interceding-token ngrams: ( CRM1t+e1: ents2Label-mention-ngram: export to thet^e2: trigger-arg-path: promotes:Positive_activation >dobj >poss controlled:Gene_or_gene_productt(interceding-token ngrams: exportins sucht'e1: ents2Label-mention-ngram: export totqe2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controllertoe2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj >poss controlled:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] Gene_or_gene_productt$interceding-token ngrams: chromosomet[e2: trigger-arg-path: lemmatizedTrigger=promote >dobj >poss controlled:Gene_or_gene_productt#interceding-token ngrams: exportinst.interceding-token ngrams: as chromosome regiont4e1: args2Role-mention-ngram: phosphorylation inducest'interceding-token ngrams: . By contrastt$e1: ents2Label-mention-ngram: exporttJe2: trigger-arg-path: Positive_activation >dobj >poss Gene_or_gene_productt?e2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controller:Gene_or_gene_producttue1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controllert]e2: trigger-arg-path: promotes >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controllertre1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controllert?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controller:Gene_or_gene_producttLe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT -mediated phosphorylationt+e1: ents2Label-mention-ngram: the cytoplasmt?e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controllert?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controller:Gene_or_gene_productt0interceding-token ngrams: through exportins suchtae1: trigger-arg-path: induces >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controllert{e2: trigger-arg-path: promotes:Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] Gene_or_gene_productt interceding-token ngrams: CRM1 )t>e1: args2Role-mention-ngram: -mediated phosphorylation inducest.e1: ents2Label-mention-ngram: SHARED 's exportt"interceding-token ngrams: CRM1 ) ,te2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='presence'] >poss [lemma='snail1'] controlled:Gene_or_gene_productt.interceding-token ngrams: region maintenance 1t?e1: ents2Label-mention-ngram: -mediated phosphorylation inducest,interceding-token ngrams: such as chromosomet5e2: args2Role-mention-ngram: phosphorylation promotestte2: trigger-arg-path: lemmatizedTrigger=promote >dobj [lemma='presence'] >poss [lemma='snail1'] Gene_or_gene_productt7interceding-token ngrams: chromosome region maintenancet}e2: trigger-arg-path: Positive_activation >nsubj [lemma='phosphorylation'] >nn [lemma='pak1'] controller:Gene_or_gene_productt interceding-token ngrams: , . Byt?e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controller:Gene_or_gene_producttrinterceding-tokens-full-span: through exportins such as chromosome region maintenance 1 ( CRM1 ) , . By contrast ,t"interceding-token ngrams: 1 ( CRM1tYe2: trigger-arg-path: promotes >dobj [lemma='presence'] >poss [lemma='snail1'] controlledtwe2: trigger-arg-path: promotes:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] Gene_or_gene_producttne2: trigger-arg-path: promotes >dobj [lemma='presence'] >poss [lemma='snail1'] controlled:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=promote:Positive_activation >dobj [lemma='presence'] >poss [lemma='snail1'] controlledtPe2: trigger-arg-path: lemmatizedTrigger=promote >dobj >poss Gene_or_gene_producttme1: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >nn [lemma='gsk-3beta'] controllertSe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_producttNe2: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] themet,e1: ents2Label-mention-ngram: , VEGF-B bindstje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: , VEGF-B bindst\e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] Gene_or_gene_producttQe2: trigger-arg-path: binds >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttDe2: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] themet+e2: args2Role-mention-ngram: , VEGF-B bindst$e1: ents2Label-mention-ngram: VEGF-BtMe2: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_producttYe2: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttprep_to [lemma='vegfr-1'] themet$e2: ents2Label-mention-ngram: VEGF-BtPe1: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] themetde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_productt>e1: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] themetAe2: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] themet9e1: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] themet#e1: args2Role-mention-ngram: VEGF-Bt*e1: ents2Label-mention-ngram: VEGF-B bindstKe1: trigger-arg-path: binds >prep_to [lemma='vegfr-1'] Gene_or_gene_producttPe2: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] themetVe1: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED , VEGF-Bt*e2: ents2Label-mention-ngram: VEGF-B bindst+e1: args2Role-mention-ngram: , VEGF-B bindst#e2: args2Role-mention-ngram: VEGF-Bt_e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: VEGF-B binds totHe2: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] Gene_or_gene_producttKe2: trigger-arg-path: binds >prep_to [lemma='vegfr-1'] Gene_or_gene_producttQe1: trigger-arg-path: binds >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] Gene_or_gene_productt,e1: args2Role-mention-ngram: VEGF-B binds totVe2: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] themetSe2: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: VEGF-B binds tot+e2: args2Role-mention-ngram: THEME , VEGF-BtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] themetJe2: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_productt%e2: args2Role-mention-ngram: , VEGF-Btbe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: VEGF-B bindst>e2: trigger-arg-path: Binding >prep_to [lemma='vegfr-1'] themetbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] theme:Gene_or_gene_producttHe1: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] themet;e2: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] themet%e1: args2Role-mention-ngram: , VEGF-Bt-e1: ents2Label-mention-ngram: SHARED , VEGF-Bt&e1: ents2Label-mention-ngram: , VEGF-Btae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: VEGF-B binds tot&e2: ents2Label-mention-ngram: , VEGF-BtNe1: trigger-arg-path: binds >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_producttDe1: trigger-arg-path: binds:Binding >prep_to [lemma='vegfr-1'] themetMe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vegfr-1'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vegfr-1'] themetPe2: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='VEGF-A'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME , VEGF-Bt)e1: args2Role-mention-ngram: VEGF-B bindstPe1: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] theme:Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >nsubj [lemma='VEGF-A'] themet;e1: trigger-arg-path: Binding >nsubj [lemma='VEGF-A'] themetprep_to [lemma='vegfr-1'] themet@e1: trigger-arg-path: binds:Binding >nsubj [lemma='atrip'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='atrip'] themet,interceding-token ngrams: recruitment of ATRt$interceding-token ngrams: to the DNAt"interceding-token ngrams: lesion .t%interceding-token ngrams: and therebyt-interceding-token ngrams: and thereby resultst]e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ssdna'] >nn [lemma='rpa'] themet+interceding-token ngrams: lesion . Althought`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='atrip'] Gene_or_gene_productt)interceding-token ngrams: the associationtinterceding-token ngrams: ATRtTe1: trigger-arg-path: binds:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] themetOe1: trigger-arg-path: binds:Binding >nsubj [lemma='atrip'] Gene_or_gene_producttLe1: trigger-arg-path: binds >prep_to [lemma='ssdna'] >nn [lemma='rpa'] themet&interceding-token ngrams: coated ssDNAt8e1: trigger-arg-path: binds >nsubj [lemma='atrip'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='atrip'] themet interceding-token ngrams: ATR tot&interceding-token ngrams: DNA lesion .tOe1: trigger-arg-path: Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] Familyt?interceding-tokens-full-span: coated ssDNA and thereby results in the recruitment of ATR to the DNA lesion . Although the association of thetXe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='atrip'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] Familytfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='atrip'] theme:Gene_or_gene_productt#interceding-token ngrams: ssDNA andt$interceding-token ngrams: DNA lesiontNe1: trigger-arg-path: Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] themet interceding-token ngrams: lesiont^e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='atrip'] theme:Gene_or_gene_productt&interceding-token ngrams: Although thetUe1: trigger-arg-path: Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] theme:Familytle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] theme:Familyt*interceding-token ngrams: coated ssDNA andtSe1: trigger-arg-path: binds >prep_to [lemma='ssdna'] >nn [lemma='rpa'] theme:FamilytGe1: trigger-arg-path: binds >nsubj [lemma='atrip'] Gene_or_gene_productt,interceding-token ngrams: thereby results int'e1: ents2Label-mention-ngram: to FAMILYt(interceding-token ngrams: . Although thet,interceding-token ngrams: in the recruitmentt1CSSPATH: ROOT  ++ ROOT >advcl >nsubjpass >prep_oftde1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ssdna'] >nn [lemma='rpa'] theme:FamilytMe1: trigger-arg-path: binds >nsubj [lemma='atrip'] theme:Gene_or_gene_productt,interceding-token ngrams: the association oftIe1: trigger-arg-path: Binding >nsubj [lemma='atrip'] Gene_or_gene_productt)interceding-token ngrams: thereby resultstfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] Familyt-e1: ents2Label-mention-ngram: binds to FAMILYt interceding-token ngrams: coatedt:e1: trigger-arg-path: Binding >nsubj [lemma='atrip'] themet(interceding-token ngrams: the DNA lesiont,interceding-token ngrams: association of thet+interceding-token ngrams: ssDNA and therebyt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='ssdna'] >nn [lemma='rpa'] Familyt$interceding-token ngrams: ATR to thetOe1: trigger-arg-path: Binding >nsubj [lemma='atrip'] theme:Gene_or_gene_producttMe1: trigger-arg-path: binds >prep_to [lemma='ssdna'] >nn [lemma='rpa'] FamilytUe1: trigger-arg-path: binds:Binding >nsubj [lemma='atrip'] theme:Gene_or_gene_productt interceding-token ngrams: of ATRt[e1: trigger-arg-path: binds:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] theme:Familyt#interceding-token ngrams: of ATR totee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='ssdna'] >nn [lemma='rpa'] themetinterceding-token ngrams: ssDNAt2interceding-token ngrams: Although the associationtSe2: trigger-arg-path: inhibits:Positive_activation >nsubj [lemma='wsb1'] controllert7e1: trigger-arg-path: binds >nsubj [lemma='wsb1'] themethe2: trigger-arg-path: inhibits:Positive_activation >nsubj [lemma='wsb1'] controller:Gene_or_gene_producttkinterceding-tokens-full-span: ( IL-21R ; Nara et al. , ) . However , instead of promoting its degradation ,t'e2: args2Role-mention-ngram: the maturetRe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of >prep_of controlledtye2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='wsb1'] controller:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='wsb1'] themet"interceding-token ngrams: ( IL-21RtVe2: trigger-arg-path: Positive_activation >dobj >prep_of >prep_of Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of >prep_of controlled:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj Gene_or_gene_productt*e2: args2Role-mention-ngram: of the maturet_e2: trigger-arg-path: inhibits:Positive_activation >dobj >prep_of >prep_of Gene_or_gene_productt,e2: ents2Label-mention-ngram: mature form oft+interceding-token ngrams: its degradation ,tNe1: trigger-arg-path: Binding >nsubj [lemma='wsb1'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: mature form oft"interceding-token ngrams: IL-21R ;tUe2: trigger-arg-path: inhibits:Positive_activation >dobj >prep_of >prep_of controlledtinterceding-token ngrams: Narat-e2: ents2Label-mention-ngram: the mature formtae2: trigger-arg-path: Positive_activation >dobj >prep_of >prep_of controlled:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='wsb1'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlledt9e1: trigger-arg-path: Binding >nsubj [lemma='wsb1'] themet/e2: args2Role-mention-ngram: form of CONTROLLEDt3interceding-token ngrams: promoting its degradationt$e2: ents2Label-mention-ngram: maturet(e2: args2Role-mention-ngram: mature formt.interceding-token ngrams: instead of promotingt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlled:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='wsb1'] Gene_or_gene_producttVe2: trigger-arg-path: inhibits >dobj >prep_of >prep_of controlled:Gene_or_gene_productt6e2: ents2Label-mention-ngram: inhibits the degradationtpe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj >prep_of >prep_of Gene_or_gene_producttNe2: trigger-arg-path: inhibits:Positive_activation >nsubj Gene_or_gene_productt+e2: ents2Label-mention-ngram: of the maturet,e2: ents2Label-mention-ngram: form of SHAREDt'interceding-token ngrams: promoting itst#interceding-token ngrams: , insteadt,e2: args2Role-mention-ngram: the mature formt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlledt{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj >prep_of >prep_of controlled:Gene_or_gene_producttAe2: trigger-arg-path: inhibits >dobj >prep_of >prep_of controlledt interceding-token ngrams: IL-21Rt?e1: trigger-arg-path: binds:Binding >nsubj [lemma='wsb1'] themetIe2: trigger-arg-path: inhibits >nsubj [lemma='wsb1'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED inhibits thetLe1: trigger-arg-path: binds >prep_to [lemma='receptor'] Gene_or_gene_productt?e2: trigger-arg-path: inhibits >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlled:Gene_or_gene_producttTe1: trigger-arg-path: binds:Binding >prep_to [lemma='receptor'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlled:Gene_or_gene_producttYe2: trigger-arg-path: inhibits:Positive_activation >nsubj controller:Gene_or_gene_producttwe2: trigger-arg-path: inhibits >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlledt$interceding-token ngrams: ( IL-21R ;t#e2: args2Role-mention-ngram: maturet+interceding-token ngrams: However , insteadt\e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >prep_of >prep_of Gene_or_gene_producttDe2: trigger-arg-path: inhibits:Positive_activation >nsubj controllert5e2: args2Role-mention-ngram: inhibits the degradationtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='wsb1'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: form oft#interceding-token ngrams: ; Nara ett?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] Gene_or_gene_producttTe2: trigger-arg-path: Positive_activation >nsubj [lemma='wsb1'] Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='wsb1'] Gene_or_gene_productt?e2: trigger-arg-path: inhibits:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlledtPe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='wsb1'] controllertUe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj controllert%interceding-token ngrams: ) . HowevertKe2: trigger-arg-path: inhibits >dobj >prep_of >prep_of Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='wsb1'] themetde2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='wsb1'] controllertee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='wsb1'] theme:Gene_or_gene_productt&interceding-token ngrams: , instead oft4e2: args2Role-mention-ngram: CONTROLLER inhibits thetJe2: trigger-arg-path: Positive_activation >nsubj [lemma='wsb1'] controllertRe1: trigger-arg-path: binds >prep_to [lemma='receptor'] theme:Gene_or_gene_productt]e2: trigger-arg-path: inhibits:Positive_activation >nsubj [lemma='wsb1'] Gene_or_gene_producttTe2: trigger-arg-path: inhibits >nsubj [lemma='wsb1'] controller:Gene_or_gene_productt&interceding-token ngrams: of promotingt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlledtfe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj >prep_of >prep_of controlledtNe1: trigger-arg-path: binds:Binding >nsubj [lemma='wsb1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='wsb1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='wsb1'] Gene_or_gene_producttLe2: trigger-arg-path: Positive_activation >dobj >prep_of >prep_of controlledtee2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='wsb1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: inhibits:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] Gene_or_gene_productt*interceding-token ngrams: of promoting itst interceding-token ngrams: ; Narat?e2: trigger-arg-path: inhibits:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] Gene_or_gene_productt'interceding-token ngrams: IL-21R ; Narat$e2: args2Role-mention-ngram: form oftEe1: trigger-arg-path: binds:Binding >prep_to [lemma='receptor'] themet?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] controlled:Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >nsubj [lemma='wsb1'] controller:Gene_or_gene_producttje2: trigger-arg-path: inhibits:Positive_activation >dobj >prep_of >prep_of controlled:Gene_or_gene_producttZe1: trigger-arg-path: binds:Binding >prep_to [lemma='receptor'] theme:Gene_or_gene_productt!interceding-token ngrams: Nara ett?e2: trigger-arg-path: inhibits >nsubj [lemma='wsb1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] Gene_or_gene_productt%interceding-token ngrams: Nara et al.t=e1: trigger-arg-path: binds >prep_to [lemma='receptor'] themetLe1: trigger-arg-path: binds >nsubj [lemma='wsb1'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: the maturetje2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj controller:Gene_or_gene_productt$interceding-token ngrams: instead oftTe1: trigger-arg-path: binds:Binding >nsubj [lemma='wsb1'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: mature formt?e2: trigger-arg-path: inhibits >dobj [lemma='degradation'] >prep_of [lemma='form'] >prep_of [lemma='il-21r'] Gene_or_gene_producttFe1: trigger-arg-path: binds >nsubj [lemma='wsb1'] Gene_or_gene_productt8e2: args2Role-mention-ngram: CONTROLLER scaffold proteint}e2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='protein'] >nn [lemma='shoc2'] controller:Gene_or_gene_productt6interceding-token ngrams: These observations indicatedtqe1: trigger-arg-path: lemmatizedTrigger=bind nsubj >nn controller:Gene_or_gene_productt=e2: trigger-arg-path: lemmatizedTrigger=modulate >dobj FamilytNe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='ra'] controlledtbe1: trigger-arg-path: lemmatizedTrigger=bind nsubj >nn Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj >nn controller:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='protein'] >nn [lemma='shoc2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] Gene_or_gene_productt?e2: trigger-arg-path: modulates:Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: , a scaffoldt$interceding-token ngrams: and Raf1 .t>e1: trigger-arg-path: binds dobj Familyt0e1: ents2Label-mention-ngram: protein that bindstDe2: trigger-arg-path: modulates >dobj [lemma='ra'] controlled:Familyt5interceding-token ngrams: observations indicated thattje1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='protein'] >nn [lemma='shoc2'] controllert/e1: ents2Label-mention-ngram: binds both SHAREDtSe1: trigger-arg-path: Binding xcomp >agent >prep_of >appos >rcmod ++ ROOT >ccompt-e1: args2Role-mention-ngram: scaffold proteint.e2: args2Role-mention-ngram: protein modulatestQe2: trigger-arg-path: modulates:Positive_activation >dobj [lemma='ra'] controlledtFe1: trigger-arg-path: Binding nsubj >nn controllert[e2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn controller:Gene_or_gene_producttne1: trigger-arg-path: binds:Binding nsubj [lemma='protein'] >nn [lemma='shoc2'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED scaffoldtOe1: trigger-arg-path: lemmatizedTrigger=bind nsubj >nn controllert)e1: args2Role-mention-ngram: protein thatt9e2: trigger-arg-path: modulates >dobj [lemma='ra'] Familytbe2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='ra'] controlledtDe2: trigger-arg-path: modulates:Positive_activation >dobj controlledtWe2: trigger-arg-path: modulates >nsubj [lemma='protein'] >nn [lemma='shoc2'] controllertLe1: trigger-arg-path: binds:Binding dobj Familytae2: trigger-arg-path: Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] controllerthe1: trigger-arg-path: binds:Binding dobj [lemma='ra'] controlled:Familyt/e1: args2Role-mention-ngram: a scaffold proteint/e1: trigger-arg-path: binds nsubj [lemma='protein'] >nn [lemma='shoc2'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: a scaffold proteintAe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj controlledtle2: trigger-arg-path: modulates >nsubj [lemma='protein'] >nn [lemma='shoc2'] controller:Gene_or_gene_productt,interceding-token ngrams: These observationst*e1: ents2Label-mention-ngram: , a scaffoldt8e2: ents2Label-mention-ngram: scaffold protein modulatest7e2: trigger-arg-path: modulates >dobj controlled:Familyt&e1: args2Role-mention-ngram: THEME , at&interceding-token ngrams: observationst)e1: ents2Label-mention-ngram: both SHAREDtQe1: trigger-arg-path: binds dobj [lemma='ra'] controlled:Familytye1: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj >nn controllert9e2: args2Role-mention-ngram: protein modulates CONTROLLEDt@e1: trigger-arg-path: lemmatizedTrigger=bind nsubj >nn controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: scaffold proteint&e2: ents2Label-mention-ngram: scaffoldtue2: trigger-arg-path: modulates:Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] Gene_or_gene_productt7e2: args2Role-mention-ngram: scaffold protein modulatest&e1: ents2Label-mention-ngram: scaffoldte1: trigger-arg-path: lemmatizedTrigger=bind:Binding dobj [lemma='ra'] controlledt?e2: trigger-arg-path: modulates >nsubj >nn Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] controllertve2: trigger-arg-path: Positive_activation >nsubj [lemma='protein'] >nn [lemma='shoc2'] controller:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='ra'] Familyt0e2: trigger-arg-path: modulates >dobj controlledt*e1: ents2Label-mention-ngram: protein thattde2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >nsubj >nn Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj [lemma='protein'] >nn [lemma='shoc2'] Gene_or_gene_producttKe2: trigger-arg-path: modulates:Positive_activation >dobj controlled:Familyt'e1: args2Role-mention-ngram: a scaffoldt1e2: args2Role-mention-ngram: modulates CONTROLLEDt&interceding-token ngrams: Raf1 . ThesetUe2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj controlledtHe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj controlled:Familyte2: trigger: modulatest'e1: args2Role-mention-ngram: binds botht'e1: args2Role-mention-ngram: both THEMEt.e2: ents2Label-mention-ngram: modulates SHAREDt.interceding-token ngrams: . These observationst-e2: args2Role-mention-ngram: scaffold proteint2e1: args2Role-mention-ngram: scaffold protein thatt^e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='ra'] Familyt0interceding-token ngrams: observations indicatedtfe1: trigger-arg-path: binds dobj [lemma='ra'] controlled:Familytae2: trigger-arg-path: modulates >nsubj [lemma='protein'] >nn [lemma='shoc2'] Gene_or_gene_producttMe2: trigger-arg-path: modulates:Positive_activation >dobj [lemma='ra'] FamilytPe2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn Gene_or_gene_productt&e2: args2Role-mention-ngram: modulatest0e2: args2Role-mention-ngram: CONTROLLER scaffoldt7e1: trigger-arg-path: binds:Binding dobj Familyt,e1: args2Role-mention-ngram: that binds botht3e1: ents2Label-mention-ngram: scaffold protein thattHe1: trigger-arg-path: lemmatizedTrigger=bind:Binding dobj controlled:FamilytFe2: trigger-arg-path: lemmatizedTrigger=modulate >nsubj >nn controllert.e1: ents2Label-mention-ngram: scaffold proteinthe1: trigger-arg-path: lemmatizedTrigger=induce nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtfe2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='ir'] controller:Gene_or_gene_productt;e1: ents2Label-mention-ngram: induce SHARED phosphorylationt+e1: ents2Label-mention-ngram: induce SHAREDt&interceding-token ngrams: sensitive totNe2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='ir'] controllert1interceding-token ngrams: , basal phopshorylationt1e1: args2Role-mention-ngram: which constitutivelytGe2: trigger-arg-path: enhanced >agent [lemma='ir'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent controller:Gene_or_gene_productt"interceding-token ngrams: K-RAS mtt%e2: args2Role-mention-ngram: wt cellst0e2: args2Role-mention-ngram: further enhanced byt(interceding-token ngrams: of the culturet"interceding-token ngrams: to serumtAe1: trigger-arg-path: induce dobj [lemma='phosphorylation'] Phosphorylationt,interceding-token ngrams: to serum depletiontqe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation agent controllertRe2: trigger-arg-path: enhanced >agent [lemma='ir'] controller:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='ir'] controllertSe2: trigger-arg-path: enhanced >nsubjpass [lemma='phosphorylation'] Phosphorylationt|e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation agent [lemma='ir'] Gene_or_gene_producttHe2: trigger-arg-path: Positive_regulation >agent [lemma='ir'] controllertYe2: trigger-arg-path: enhanced:Positive_regulation >agent controller:Gene_or_gene_productt9e2: trigger-arg-path: enhanced >nsubjpass Phosphorylationt&e1: ents2Label-mention-ngram: and AREGt]e1: trigger-arg-path: lemmatizedTrigger=induce agent controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: K-RAS wt cellstUe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent controllertinterceding-token ngrams: basalt_e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent Gene_or_gene_productt)e2: ents2Label-mention-ngram: in K-RAS wttAe1: trigger-arg-path: induce:Positive_regulation >dobj controlledtXe2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass controlled:Phosphorylationt,e2: ents2Label-mention-ngram: K-RAS wt cellst%interceding-token ngrams: , and basalt0e2: trigger-arg-path: enhanced >agent controllertVe2: trigger-arg-path: lemmatizedTrigger=enhance >agent controller:Gene_or_gene_productt,interceding-token ngrams: sensitive to serumtinterceding-token ngrams: YB-1tJe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass Phosphorylationt-e1: trigger-arg-path: induce >dobj controlledtge2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass [lemma='phosphorylation'] PhosphorylationtKe2: trigger-arg-path: lemmatizedTrigger=enhance >agent Gene_or_gene_productt"interceding-token ngrams: K-RAS wtt,interceding-token ngrams: the culture mediumt"interceding-token ngrams: mt cellst"e2: args2Role-mention-ngram: K-RASt!e1: args2Role-mention-ngram: AREGt!interceding-token ngrams: culturet$e1: ents2Label-mention-ngram: AREG ,t#e2: ents2Label-mention-ngram: K-RASt+interceding-token ngrams: contrast to K-RAStLe1: trigger-arg-path: induce:Positive_regulation agent [lemma='ir'] Gene_or_gene_producttinterceding-token ngrams: serumtUe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass controlled:Phosphorylationt!interceding-token ngrams: YB-1 int-e2: args2Role-mention-ngram: further enhancedt@e1: trigger-arg-path: lemmatizedTrigger=induce agent Gene_or_gene_producttNe1: trigger-arg-path: Positive_regulation e2: ents2Label-mention-ngram: enhanced by GENE_OR_GENE_PRODUCTt'e2: ents2Label-mention-ngram: cells cant^e2: trigger-arg-path: enhanced >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt[e2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='ir'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: which constitutively inducet)interceding-token ngrams: phopshorylationt&e2: args2Role-mention-ngram: cells cant`e1: trigger-arg-path: induce:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt!interceding-token ngrams: of YB-1t:e2: trigger-arg-path: enhanced >agent Gene_or_gene_productt*e2: ents2Label-mention-ngram: cells can bet#interceding-token ngrams: and basaltGe1: trigger-arg-path: induce >dobj [lemma='phosphorylation'] controlledtYe2: trigger-arg-path: Positive_regulation >nsubjpass [lemma='phosphorylation'] controlledtwe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >agent [lemma='ir'] controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: in K-RASt(e2: args2Role-mention-ngram: in K-RAS wtt=e1: trigger-arg-path: induce >dobj controlled:Phosphorylationt%e2: args2Role-mention-ngram: K-RAS wtt_e1: trigger-arg-path: induce:Positive_regulation nsubjpass [lemma='phosphorylation'] controlled:PhosphorylationtUe1: trigger-arg-path: induce:Positive_regulation nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt"interceding-token ngrams: to K-RASt=e1: args2Role-mention-ngram: constitutively induce CONTROLLEDt!interceding-token ngrams: , basaltje1: trigger-arg-path: induce:Positive_regulation nsubjpass [lemma='phosphorylation'] PhosphorylationtDe2: trigger-arg-path: Positive_regulation >nsubjpass PhosphorylationtOe2: trigger-arg-path: Positive_regulation >nsubjpass controlled:Phosphorylationt'e1: args2Role-mention-ngram: and AREG ,t&e2: ents2Label-mention-ngram: in K-RASt?interceding-tokens-full-span: . In contrast to K-RAS mt cells , basal phopshorylation of YB-1 in K-RAS wt cells is sensitive to serum depletion of the culture medium , and basalt&e2: ents2Label-mention-ngram: K-RAS wttTe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubjpass [lemma='phosphorylation'] controlledtCe1: trigger-arg-path: induce nsubjpass [lemma='phosphorylation'] controlledtDe2: trigger-arg-path: enhanced:Positive_regulation >agent controllertWe1: trigger-arg-path: induce >dobj [lemma='phosphorylation'] controlled:Phosphorylationtce2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='ir'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass [lemma='phosphorylation'] Phosphorylationt(interceding-token ngrams: culture mediumt1e2: ents2Label-mention-ngram: further enhanced bytQe2: trigger-arg-path: enhanced:Positive_regulation >agent [lemma='ir'] controllertSe1: trigger-arg-path: lemmatizedTrigger=induce prep_in >prep_such_as >rcmod ++ ROOT >conj_andt)e2: args2Role-mention-ngram: cells can bet[e1: trigger-arg-path: induce:Positive_regulation >dobj [lemma='phosphorylation'] controlledt*e2: ents2Label-mention-ngram: wt cells cantce1: trigger-arg-path: Positive_regulation nsubjpass [lemma='phosphorylation'] controlledt(e1: ents2Label-mention-ngram: and AREG ,t8e1: args2Role-mention-ngram: which constitutively inducet^e2: trigger-arg-path: Positive_regulation >nsubjpass [lemma='phosphorylation'] Phosphorylationt)e1: args2Role-mention-ngram: AREG , whichtKe1: trigger-arg-path: induce agent [lemma='ir'] controller:Gene_or_gene_productt#interceding-token ngrams: sensitivet1interceding-token ngrams: phopshorylation of YB-1t*interceding-token ngrams: culture medium ,t1e2: ents2Label-mention-ngram: be further enhancedt^e2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass Phosphorylationt3e1: ents2Label-mention-ngram: constitutively inducetke1: trigger-arg-path: induce:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt$interceding-token ngrams: of YB-1 int4e1: ents2Label-mention-ngram: , which constitutivelyt=e2: trigger-arg-path: enhanced >agent [lemma='ir'] controllert7e2: ents2Label-mention-ngram: SHARED phosphorylation intDe2: trigger-arg-path: enhanced >nsubjpass controlled:PhosphorylationtXe2: trigger-arg-path: lemmatizedTrigger=enhance >agent [lemma='ir'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubjpass controlled:PhosphorylationtQe1: trigger-arg-path: induce:Positive_regulation >dobj controlled:PhosphorylationtFe1: trigger-arg-path: induce:Positive_regulation >dobj Phosphorylationt2e1: trigger-arg-path: induce >dobj Phosphorylationt$interceding-token ngrams: mt cells ,tNe2: trigger-arg-path: enhanced >nsubjpass [lemma='phosphorylation'] controlledtMe2: trigger-arg-path: enhanced:Positive_regulation >nsubjpass Phosphorylationt%interceding-token ngrams: wt cells istoe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt3e1: args2Role-mention-ngram: interaction between wtt-e1: args2Role-mention-ngram: between wt THEMEt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound wtt,interceding-token ngrams: Ras complexed withtRe1: trigger-arg-path: interaction >prep_between [lemma='gdp'] Gene_or_gene_productt)interceding-token ngrams: abundant GTP tot+interceding-token ngrams: of the cellularlytKe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gdp'] themet'interceding-token ngrams: Ras complexedt$interceding-token ngrams: GTP to thetle1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gdp'] Gene_or_gene_productt(interceding-token ngrams: is the bindingt'e1: args2Role-mention-ngram: between wtt`e1: trigger-arg-path: interaction:Binding >prep_between [lemma='gdp'] theme:Gene_or_gene_productt interceding-token ngrams: GTP tot#interceding-token ngrams: to the wtt$interceding-token ngrams: cellularlytre1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gdp'] theme:Gene_or_gene_producttTe1: trigger-arg-path: Binding >prep_between [lemma='gdp'] theme:Gene_or_gene_productt"interceding-token ngrams: abundanttNe1: trigger-arg-path: Binding >prep_between [lemma='gdp'] Gene_or_gene_producttCe1: trigger-arg-path: interaction >prep_between [lemma='gdp'] themet&interceding-token ngrams: abundant GTPt1interceding-token ngrams: cellularly abundant GTPtXe1: trigger-arg-path: interaction >prep_between [lemma='gdp'] theme:Gene_or_gene_productt(interceding-token ngrams: binding of thet1interceding-token ngrams: the cellularly abundantt?e1: trigger-arg-path: Binding >prep_between [lemma='gdp'] themet]e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='gdp'] themetde1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gdp'] Gene_or_gene_productt)e1: args2Role-mention-ngram: wt THEME andtZe1: trigger-arg-path: interaction:Binding >prep_between [lemma='gdp'] Gene_or_gene_productt*interceding-token ngrams: wt Ras complexedt(interceding-token ngrams: the cellularlytinterceding-tokens-full-span: , resulting in release of the bound GDP to produce the wt Ras Cdc25 binary complex . The second step is the binding of the cellularly abundant GTP to the wt Ras complexed with Cdc25 ; this binding expels the bound Cdc25 from wt Ras to producetUe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gdp'] themet-interceding-token ngrams: cellularly abundanttje1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='gdp'] theme:Gene_or_gene_productt3CSSPATH: ROOT >dobj ++ ROOT >parataxis >vmod >ccomptMe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='exo84'] themet,interceding-token ngrams: the morphology andt'interceding-token ngrams: and polarizedtPe2: trigger-arg-path: interaction >nn [lemma='exo84'] theme:Gene_or_gene_productt%interceding-token ngrams: of neuronaltUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ralum'] themet-interceding-token ngrams: polarized migrationt7e2: trigger-arg-path: Binding >nn [lemma='ralum'] themet^e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ralum'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Binding >nn [lemma='ralum'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='exo84'] theme:Gene_or_gene_productt?e1: trigger-arg-path: complex:Binding >nn [lemma='exo84'] themetRe2: trigger-arg-path: interaction:Binding >nn [lemma='exo84'] Gene_or_gene_productt&interceding-token ngrams: cells . Losstde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ralum'] Gene_or_gene_producttFe1: trigger-arg-path: complex >nn [lemma='exo84'] Gene_or_gene_producttPe2: trigger-arg-path: interaction >nn [lemma='ralum'] theme:Gene_or_gene_productt%interceding-token ngrams: is known totLe1: trigger-arg-path: Binding >nn [lemma='ralum'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='ralum'] Gene_or_gene_producttNe1: trigger-arg-path: complex:Binding >nn [lemma='ralum'] Gene_or_gene_productt7e1: trigger-arg-path: Binding >nn [lemma='ralum'] themet,interceding-token ngrams: progenitor cells .tUe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='exo84'] themetQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ralum'] themet*interceding-token ngrams: progenitor cellst7e2: trigger-arg-path: Binding >nn [lemma='exo84'] themetLe1: trigger-arg-path: Binding >nn [lemma='exo84'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interaction:Binding >nn [lemma='exo84'] themet7e1: trigger-arg-path: complex >nn [lemma='ralum'] themet`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='exo84'] Gene_or_gene_productt(interceding-token ngrams: morphology andtXe2: trigger-arg-path: interaction:Binding >nn [lemma='ralum'] theme:Gene_or_gene_producttXe2: trigger-arg-path: interaction:Binding >nn [lemma='exo84'] theme:Gene_or_gene_producttTe1: trigger-arg-path: complex:Binding >nn [lemma='ralum'] theme:Gene_or_gene_productt1interceding-token ngrams: regulate the morphologytbe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='exo84'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='exo84'] Gene_or_gene_producttFe1: trigger-arg-path: Binding >nn [lemma='exo84'] Gene_or_gene_productt?interceding-tokens-full-span: is known to regulate the morphology and polarized migration of neuronal progenitor cells . Loss of thet2interceding-token ngrams: morphology and polarizedtTe1: trigger-arg-path: complex:Binding >nn [lemma='exo84'] theme:Gene_or_gene_productt$interceding-token ngrams: morphologytXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='exo84'] Gene_or_gene_productt7e1: trigger-arg-path: Binding >nn [lemma='exo84'] themetRe2: trigger-arg-path: interaction:Binding >nn [lemma='ralum'] Gene_or_gene_productt#interceding-token ngrams: polarizedtbe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ralum'] theme:Gene_or_gene_productt%interceding-token ngrams: Loss of thet1interceding-token ngrams: and polarized migrationtIe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ralum'] themet7e1: trigger-arg-path: complex >nn [lemma='exo84'] themet0CSSPATH: ROOT >nsubjpass ++ ROOT >nsubj >prep_oft0interceding-token ngrams: polarized migration oft`e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ralum'] Gene_or_gene_productt0interceding-token ngrams: of neuronal progenitortFe1: trigger-arg-path: complex >nn [lemma='ralum'] Gene_or_gene_productt$interceding-token ngrams: progenitort4e2: ents2Label-mention-ngram: and SHARED interactiont(interceding-token ngrams: the morphologyt&interceding-token ngrams: regulate thet+interceding-token ngrams: known to regulatetJe2: trigger-arg-path: interaction >nn [lemma='exo84'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='exo84'] themetMe2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ralum'] themetje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='exo84'] theme:Gene_or_gene_productt;e2: trigger-arg-path: interaction >nn [lemma='ralum'] themetIe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='exo84'] themet/interceding-token ngrams: migration of neuronalt"interceding-token ngrams: is knowntde2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='exo84'] Gene_or_gene_productt-interceding-token ngrams: neuronal progenitortNe1: trigger-arg-path: complex:Binding >nn [lemma='exo84'] Gene_or_gene_producttLe1: trigger-arg-path: complex >nn [lemma='exo84'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=interaction >nn [lemma='ralum'] Gene_or_gene_productt)interceding-token ngrams: to regulate thetje2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >nn [lemma='ralum'] theme:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='exo84'] theme:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ralum'] Gene_or_gene_producttCe2: trigger-arg-path: interaction:Binding >nn [lemma='ralum'] themet;e2: trigger-arg-path: interaction >nn [lemma='exo84'] themetLe1: trigger-arg-path: complex >nn [lemma='ralum'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding >nn [lemma='ralum'] Gene_or_gene_producttJe2: trigger-arg-path: interaction >nn [lemma='ralum'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ralum'] theme:Gene_or_gene_productt?e1: trigger-arg-path: complex:Binding >nn [lemma='ralum'] themet3interceding-token ngrams: neuronal progenitor cellstFe2: trigger-arg-path: Binding >nn [lemma='exo84'] Gene_or_gene_productt&interceding-token ngrams: migration oftLe2: trigger-arg-path: Binding >nn [lemma='exo84'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: signalling mediatingtFe1: trigger-arg-path: mediating >nsubj controller:Gene_or_gene_producttke2: trigger-arg-path: causes:Negative_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt[e2: trigger-arg-path: causes >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controllertWe2: trigger-arg-path: causes >dobj [lemma='phosphorylation'] controlled:Phosphorylationt-e2: args2Role-mention-ngram: causes increasedt`e2: trigger-arg-path: causes:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mnk1'] controller:Gene_or_gene_productt-e2: trigger-arg-path: causes >dobj controlledt0CSSPATH: ROOT >prep_through >rcmod >dep ++ ROOT tLe2: trigger-arg-path: causes >nsubj >prep_of controller:Gene_or_gene_productt&e1: args2Role-mention-ngram: mediatingtUe2: trigger-arg-path: causes:Negative_regulation >nsubj >prep_of Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj >prep_of controllertOe1: trigger-arg-path: mediating:Positive_regulation >nsubj Gene_or_gene_productt>e1: ents2Label-mention-ngram: mediating SHARED phosphorylationt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and 2tie1: trigger-arg-path: mediating:Positive_regulation >nsubj [lemma='mnk1'] controller:Gene_or_gene_productthe2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controllertve2: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: S209t&e2: ents2Label-mention-ngram: Mnks andt)e1: args2Role-mention-ngram: 2 signallingt8e2: args2Role-mention-ngram: CONTROLLER causes increasedtEe1: trigger-arg-path: mediating:Positive_regulation >nsubj controllertGe2: trigger-arg-path: causes >dobj [lemma='phosphorylation'] controlledt>e2: trigger-arg-path: lemmatizedTrigger=cause >dobj controlledt;e1: trigger-arg-path: mediating >nsubj Gene_or_gene_productt1e1: args2Role-mention-ngram: signalling mediatingte2: trigger: causest3e2: ents2Label-mention-ngram: causes increased Mnkst"e1: args2Role-mention-ngram: and 2tnsubj [lemma='mnk1'] controllertre2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj [lemma='phosphorylation'] controlledt.e1: ents2Label-mention-ngram: mediating SHAREDtZe1: trigger-arg-path: mediating:Positive_regulation >nsubj controller:Gene_or_gene_producttUe1: trigger-arg-path: mediating >nsubj [lemma='mnk1'] controller:Gene_or_gene_producttAe2: trigger-arg-path: causes >nsubj >prep_of Gene_or_gene_productt0e2: args2Role-mention-ngram: Mnks and CONTROLLEDtee2: trigger-arg-path: causes >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] Gene_or_gene_productt7e2: trigger-arg-path: causes >nsubj >prep_of controllertoe2: trigger-arg-path: causes:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controllertWe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj Phosphorylationt-e2: ents2Label-mention-ngram: Mnks and SHAREDt5e1: ents2Label-mention-ngram: phosphorylation at S209t-e1: args2Role-mention-ngram: CONTROLLER and 2t'e1: ents2Label-mention-ngram: mediatingtbe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj controlled:Phosphorylationtne1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mnk1'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=cause >dobj [lemma='phosphorylation'] controlled:PhosphorylationtNe2: trigger-arg-path: lemmatizedTrigger=cause >dobj controlled:Phosphorylationtpe2: trigger-arg-path: causes >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controller:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=cause >dobj [lemma='phosphorylation'] controlledtde1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mnk1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controllert[e2: trigger-arg-path: causes:Negative_regulation >dobj [lemma='phosphorylation'] controlledt!e2: args2Role-mention-ngram: MnkstZe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mnk1'] Gene_or_gene_productt^e1: trigger-arg-path: mediating:Positive_regulation >nsubj [lemma='mnk1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] Gene_or_gene_productt?e2: trigger-arg-path: causes:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controller:Gene_or_gene_productt=e2: trigger-arg-path: causes >dobj controlled:Phosphorylationtqe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj [lemma='phosphorylation'] Phosphorylationtye1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='mnk1'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='mnk1'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: increased Mnkst,e2: ents2Label-mention-ngram: increased Mnkst]e2: trigger-arg-path: lemmatizedTrigger=cause >dobj [lemma='phosphorylation'] Phosphorylationt2e2: trigger-arg-path: causes >dobj Phosphorylationt|e2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtRe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >dobj controlledt*e1: ents2Label-mention-ngram: 2 signallingt/e2: args2Role-mention-ngram: increased Mnks andt@e1: trigger-arg-path: mediating >nsubj [lemma='mnk1'] controllert.e2: ents2Label-mention-ngram: causes increasedt%e1: ents2Label-mention-ngram: at S209t]e2: trigger-arg-path: lemmatizedTrigger=cause >nsubj >prep_of controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: mediating CONTROLLEDt3e1: args2Role-mention-ngram: 2 signalling mediatingt?e2: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: and 2 signallingt?e2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controller:Gene_or_gene_productt1e1: trigger-arg-path: mediating >nsubj controllert0e2: ents2Label-mention-ngram: increased Mnks andtqe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT causest9e1: ents2Label-mention-ngram: signalling mediating SHAREDt4e1: ents2Label-mention-ngram: 2 signalling mediatingt}e2: trigger-arg-path: Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controller:Gene_or_gene_producttTe1: trigger-arg-path: mediating:Positive_regulation >nsubj [lemma='mnk1'] controllertTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mnk1'] Gene_or_gene_producttQe2: trigger-arg-path: causes:Negative_regulation >dobj controlled:Phosphorylationt-interceding-tokens-full-span: . Inhibition oft2e2: args2Role-mention-ngram: causes increased Mnkstle2: trigger-arg-path: lemmatizedTrigger=cause >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] controllertye2: trigger-arg-path: causes:Negative_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pp2a'] Gene_or_gene_productte1: trigger: mediatingtJe1: trigger-arg-path: mediating >nsubj [lemma='mnk1'] Gene_or_gene_producttFe2: trigger-arg-path: causes:Negative_regulation >dobj Phosphorylationt.e2: args2Role-mention-ngram: CONTROLLER causest"e2: ents2Label-mention-ngram: MnkstAe2: trigger-arg-path: causes:Negative_regulation >dobj controlledtKe2: trigger-arg-path: causes:Negative_regulation >nsubj >prep_of controllertJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mnk1'] controllert`e2: trigger-arg-path: causes:Negative_regulation >dobj [lemma='phosphorylation'] PhosphorylationtRe2: trigger-arg-path: lemmatizedTrigger=cause >nsubj >prep_of Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=cause >nsubj >prep_of controllert-e1: args2Role-mention-ngram: and 2 signallingtfe2: trigger-arg-path: lemmatizedTrigger=cause:Negative_regulation >nsubj >prep_of Gene_or_gene_productt%e2: args2Role-mention-ngram: Mnks andtCe2: trigger-arg-path: lemmatizedTrigger=cause >dobj PhosphorylationtCe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT causes increasedtLe2: trigger-arg-path: causes >dobj [lemma='phosphorylation'] Phosphorylationt4e1: ents2Label-mention-ngram: phosphorylates Nrf2 attHe1: trigger-arg-path: lemmatizedTrigger=increase nsubj controlledt&e2: ents2Label-mention-ngram: 40 , andt,e1: ents2Label-mention-ngram: Nrf2 at serinet?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] controllertqe1: trigger-arg-path: increases >dep [lemma='translocation'] >amod [lemma='nrf2'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] Gene_or_gene_producttdep [lemma='translocation'] >amod [lemma='nrf2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj [lemma='pkc'] Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='pkc'] controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj Positive_regulationtHshortest-path: advmod [lemma='directly']tCe1: ents2Label-mention-ngram: SHARED increases GENE_OR_GENE_PRODUCTtnsubj [lemma='pkc'] controlledt1e1: args2Role-mention-ngram: increases CONTROLLERtKe1: trigger-arg-path: increases:Positive_regulation nsubj controlledtIe1: trigger-arg-path: increases:Positive_regulation >dep >amod controllertpe1: trigger-arg-path: increases:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] controllertTe1: trigger-arg-path: increases:Positive_regulation nsubj Positive_regulationt{e1: trigger-arg-path: Positive_regulation nsubj [lemma='pkc'] controlled:Positive_regulationt*e2: ents2Label-mention-ngram: , and SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=increase >dep [lemma='translocation'] >amod [lemma='nrf2'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: 40 , andtpe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj controlled:Positive_regulationtKe1: trigger-arg-path: increases nsubj controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj [lemma='pkc'] controlledt\e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj controlledtme1: trigger-arg-path: lemmatizedTrigger=increase >dep [lemma='translocation'] >amod [lemma='nrf2'] controllertTe1: trigger-arg-path: Positive_regulation >dep >amod controller:Gene_or_gene_productt,e2: ents2Label-mention-ngram: Nrf2 at serinet{e1: trigger-arg-path: Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] controller:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=increase >dep >amod Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=increase nsubj controlled:Positive_regulationt1e1: ents2Label-mention-ngram: phosphorylates Nrf2tze1: trigger-arg-path: increases:Positive_regulation nsubj [lemma='pkc'] Positive_regulationtpe1: trigger-arg-path: Positive_regulation nsubj [lemma='pkc'] Positive_regulationt5e1: trigger-arg-path: increases >dep >amod controllertSe1: trigger-arg-path: increases:Positive_regulation >dep >amod Gene_or_gene_productt?e1: trigger-arg-path: increases >dep >amod Gene_or_gene_producttpe1: trigger-arg-path: Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] Gene_or_gene_producttze1: trigger-arg-path: increases:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] Gene_or_gene_productt^e1: trigger-arg-path: increases:Positive_regulation >dep >amod controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: serine 40t4e2: ents2Label-mention-ngram: phosphorylates Nrf2 att%e2: ents2Label-mention-ngram: Nrf2 att2e1: ents2Label-mention-ngram: and SHARED increasest?e1: trigger-arg-path: increases:Positive_regulation nsubj [lemma='pkc'] controlled:Positive_regulationt)e2: ents2Label-mention-ngram: serine 40 ,t@e1: trigger-arg-path: increases nsubj Positive_regulationtAe1: trigger-arg-path: Positive_regulation nsubj controlledt[e1: trigger-arg-path: lemmatizedTrigger=increase >dep >amod controller:Gene_or_gene_productt:e2: ents2Label-mention-ngram: directly phosphorylates Nrf2t"e2: ents2Label-mention-ngram: Nrf2t"e1: ents2Label-mention-ngram: 40 ,tde1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep >amod Gene_or_gene_producttJe1: trigger-arg-path: Positive_regulation nsubj Positive_regulationt?e1: trigger-arg-path: increases:Positive_regulation >dep [lemma='translocation'] >amod [lemma='nrf2'] controller:Gene_or_gene_productt1e2: ents2Label-mention-ngram: phosphorylates Nrf2tne1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='pkc'] controlledtfe1: trigger-arg-path: increases >dep [lemma='translocation'] >amod [lemma='nrf2'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: Nrf2 attfe1: trigger-arg-path: increases nsubj [lemma='pkc'] Positive_regulationt1e1: args2Role-mention-ngram: CONTROLLED increasestUe1: trigger-arg-path: Positive_regulation nsubj controlled:Positive_regulationtnsubj controlledt?e1: trigger-arg-path: Positive_regulation >dep >amod controllertJe1: trigger-arg-path: increases >dep >amod controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=increase nsubj Positive_regulationt"e2: ents2Label-mention-ngram: 40 ,t)e1: ents2Label-mention-ngram: serine 40 ,t_e1: trigger-arg-path: increases:Positive_regulation nsubj controlled:Positive_regulationt\e1: trigger-arg-path: increases >dep [lemma='translocation'] >amod [lemma='nrf2'] controllert*e1: ents2Label-mention-ngram: at serine 40twe1: trigger-arg-path: lemmatizedTrigger=increase nsubj [lemma='pkc'] Positive_regulationtIe1: trigger-arg-path: Positive_regulation >dep >amod Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=increase >dep [lemma='translocation'] >amod [lemma='nrf2'] Gene_or_gene_producttgtrigger-to-trigger-path: e1:increases:Positive_regulation advmod e2:directly:Positive_regulationt*e2: ents2Label-mention-ngram: at serine 40toe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep >amod controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >dep >amod controllert]e1: trigger-arg-path: increases nsubj [lemma='pkc'] controlledtge1: trigger-arg-path: Positive_regulation nsubj [lemma='pkc'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation nsubj [lemma='pkc'] controlled:Positive_regulationt?trigger-to-trigger-path: e1:increases:Positive_regulation advmod [lemma='directly'] e2:directly:Positive_regulationtqe1: trigger-arg-path: increases nsubj [lemma='pkc'] controlled:Positive_regulationtFe1: trigger-arg-path: lemmatizedTrigger=increase >dep >amod controllert'e2: ents2Label-mention-ngram: serine 40tYe1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='IR'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] controllertWe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] Gene_or_gene_productt"interceding-token ngrams: Figure ,tFe2: trigger-arg-path: induces >nsubj [lemma='IR'] Gene_or_gene_producttOe1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='IR'] controllertae1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] controllertae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] controllertee2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_producttQe2: trigger-arg-path: induces >nsubj [lemma='IR'] controller:Gene_or_gene_producttnsubj [lemma='IR'] controllertve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] controller:Gene_or_gene_productt interceding-token ngrams: Figuretbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] controller:Gene_or_gene_productt)interceding-token ngrams: shown in Figuret]e1: trigger-arg-path: Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_producttZe2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='IR'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] Gene_or_gene_productt#interceding-token ngrams: in Figuret*e1: ents2Label-mention-ngram: SHARED couldtWe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: SHARED could inducet]e2: trigger-arg-path: Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_producttnsubj [lemma='IR'] Gene_or_gene_productt:e2: args2Role-mention-ngram: CONTROLLER induces CONTROLLEDtde1: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_producttPe2: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='IR'] controllert)e1: args2Role-mention-ngram: could inducetHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='IR'] controllert4e1: args2Role-mention-ngram: CONTROLLER could inducetke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED induces SHAREDt4e1: args2Role-mention-ngram: could induce CONTROLLEDt,e2: ents2Label-mention-ngram: induces SHAREDtnsubj [lemma='IR'] controllert*e1: ents2Label-mention-ngram: could inducetEe1: trigger-arg-path: induce >nsubj [lemma='IR'] Gene_or_gene_productt#interceding-token ngrams: as well .tPe1: trigger-arg-path: induce >nsubj [lemma='IR'] controller:Gene_or_gene_producttHe1: trigger-arg-path: Positive_regulation >nsubj [lemma='IR'] controllert/e2: args2Role-mention-ngram: induces CONTROLLEDtve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='IR'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: could induce SHAREDtRe1: trigger-arg-path: Positive_regulation >nsubj [lemma='IR'] Gene_or_gene_productt%interceding-token ngrams: in Figure ,tMe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='IR'] controllertte2: trigger-arg-path: induced:Positive_regulation nn [lemma='YB-1'] Phosphorylationt`e2: trigger-arg-path: induced nn [lemma='YB-1'] Phosphorylationtoe2: trigger-arg-path: induced:Positive_regulation nn [lemma='YB-1'] controlledtMe2: trigger-arg-path: induced:Positive_regulation >agent Gene_or_gene_producttke2: trigger-arg-path: induced nn [lemma='YB-1'] controlled:Phosphorylationtxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='k-ra'] controller:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='k-ra'] controllert>e2: trigger-arg-path: induced >agent [lemma='k-ra'] controllertle2: trigger-arg-path: Positive_regulation nn [lemma='YB-1'] PhosphorylationtBe1: trigger-arg-path: induces:Positive_regulation >dobj controlledt[e2: trigger-arg-path: induced nn [lemma='YB-1'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='YB-1'] controlledtme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='k-ra'] Gene_or_gene_productt#CSSPATH: ROOT  ++ ROOT >nsubj >vmodt8e2: ents2Label-mention-ngram: phosphorylation induced bytGe1: trigger-arg-path: induces:Positive_regulation >dobj Phosphorylationt4e2: args2Role-mention-ngram: by oncogenic CONTROLLERtagent controller:Gene_or_gene_producttagent controllertWe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn controlledtge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn controlled:Phosphorylationt?e2: ents2Label-mention-ngram: by oncogenic GENE_OR_GENE_PRODUCTtRe1: trigger-arg-path: induces:Positive_regulation >dobj controlled:PhosphorylationtQe1: trigger-arg-path: induces >nsubj [lemma='ir'] controller:Gene_or_gene_producttCe2: trigger-arg-path: induced:Positive_regulation >agent controllertTe2: trigger-arg-path: Positive_regulation >agent [lemma='k-ra'] Gene_or_gene_productt/e2: args2Role-mention-ngram: CONTROLLED inducedtSe2: trigger-arg-path: lemmatizedTrigger=induce nn controlled:Phosphorylationt\e2: trigger-arg-path: induced:Positive_regulation >agent [lemma='k-ra'] Gene_or_gene_producttPe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ir'] controllert>e1: trigger-arg-path: induces >dobj controlled:Phosphorylationtnn [lemma='YB-1'] controlledtqe2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='YB-1'] Phosphorylationtee1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ir'] controller:Gene_or_gene_productt@e2: trigger-arg-path: lemmatizedTrigger=induce >agent controllertwe2: trigger-arg-path: Positive_regulation nn [lemma='YB-1'] controlled:PhosphorylationtHe1: trigger-arg-path: induces >dobj [lemma='phosphorylation'] controlledt1e2: args2Role-mention-ngram: induced by oncogenictXe1: trigger-arg-path: induces >dobj [lemma='phosphorylation'] controlled:Phosphorylationt3e1: trigger-arg-path: induces >dobj PhosphorylationtJe2: trigger-arg-path: Positive_regulation >agent [lemma='k-ra'] controllertHe2: trigger-arg-path: lemmatizedTrigger=induce nn PhosphorylationtYe2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='k-ra'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: by oncogenictle1: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt2e2: ents2Label-mention-ngram: induced by oncogenict5e2: ents2Label-mention-ngram: phosphorylation inducedtVe2: trigger-arg-path: induced:Positive_regulation nn controlled:PhosphorylationtKe2: trigger-arg-path: induced:Positive_regulation nn Phosphorylationtae1: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='YB-1'] PhosphorylationtFe2: trigger-arg-path: induced:Positive_regulation nn controlledtXe2: trigger-arg-path: induced:Positive_regulation >agent controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='YB-1'] controlledtHe2: trigger-arg-path: induced >agent [lemma='k-ra'] Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLED induced byt9e2: trigger-arg-path: induced >agent Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='k-ra'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=induce >agent controller:Gene_or_gene_producttge2: trigger-arg-path: induced:Positive_regulation >agent [lemma='k-ra'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: oncogenic CONTROLLERtZe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ir'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn Phosphorylationt7e2: trigger-arg-path: induced nn Phosphorylationt\e1: trigger-arg-path: induces:Positive_regulation >dobj [lemma='phosphorylation'] controlledt_e2: trigger-arg-path: Positive_regulation >agent [lemma='k-ra'] controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controllert)e2: args2Role-mention-ngram: by oncogenicte2: trigger-arg-path: induced:Positive_regulation nn [lemma='YB-1'] controlled:PhosphorylationtJe2: trigger-arg-path: lemmatizedTrigger=induce >agent Gene_or_gene_producttBe2: trigger-arg-path: induced nn controlled:PhosphorylationtSe2: trigger-arg-path: induced >agent [lemma='k-ra'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='YB-1'] controlled:Phosphorylationt^e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='k-ra'] controllert|e2: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='YB-1'] controlled:Phosphorylationtnsubj [lemma='ir'] controllertMe1: trigger-arg-path: induces >dobj [lemma='phosphorylation'] PhosphorylationtRe2: trigger-arg-path: induced:Positive_regulation >agent [lemma='k-ra'] controllertFe1: trigger-arg-path: induces >nsubj [lemma='ir'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetJe2: trigger-arg-path: Binding >nn [lemma='egf'] theme:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_productt8e1: trigger-arg-path: binding:Binding >prep_to >nn themetRe2: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themet^e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themet=e2: trigger-arg-path: binding:Binding >nn [lemma='egf'] themetse1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] themetye2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn themetRe2: trigger-arg-path: binding:Binding >nn [lemma='egf'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetie2: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] themetJe1: trigger-arg-path: Binding >nn [lemma='egf'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn theme:Gene_or_gene_producttge2: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_productt5e2: trigger-arg-path: binding >nn [lemma='egf'] themetYe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn Gene_or_gene_producttRe2: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetDe1: trigger-arg-path: binding >nn [lemma='egf'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn theme:Gene_or_gene_producttZe2: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetge2: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_productt0e1: trigger-arg-path: binding >prep_to >nn themetBe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn themetRe1: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themet\e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] theme:Gene_or_gene_producttge1: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] theme:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn themetJe2: trigger-arg-path: binding >nn [lemma='egf'] theme:Gene_or_gene_productt?e1: trigger-arg-path: binding >prep_to >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttLe2: trigger-arg-path: binding:Binding >nn [lemma='egf'] Gene_or_gene_producttge1: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttZe1: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetBe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn themetye1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttRe1: trigger-arg-path: binding:Binding >nn [lemma='egf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: Binding >nn [lemma='egf'] Gene_or_gene_producttDe2: trigger-arg-path: binding >nn [lemma='egf'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >nn theme:Gene_or_gene_productt5e1: trigger-arg-path: Binding >nn [lemma='egf'] themetoe2: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttae1: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttJe1: trigger-arg-path: binding >nn [lemma='egf'] theme:Gene_or_gene_producttGe1: trigger-arg-path: binding:Binding >prep_to >nn Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] theme:Gene_or_gene_producttEe1: trigger-arg-path: binding >prep_to >nn theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttae2: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] Gene_or_gene_producttRe1: trigger-arg-path: binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themetoe1: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='egf'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttLe1: trigger-arg-path: binding:Binding >nn [lemma='egf'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to >nn theme:Gene_or_gene_productt5e2: trigger-arg-path: Binding >nn [lemma='egf'] themetae1: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] themet5e1: trigger-arg-path: binding >nn [lemma='egf'] themet^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] themet=e1: trigger-arg-path: binding:Binding >nn [lemma='egf'] themetae2: trigger-arg-path: Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttie1: trigger-arg-path: binding:Binding >prep_to [lemma='receptor'] >nn [lemma='erbb'] Gene_or_gene_producttMe1: trigger-arg-path: binding:Binding >prep_to >nn theme:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='egf'] themetde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='egf'] theme:Gene_or_gene_producttDe1: trigger-arg-path: phosphorylated >agent [lemma='ck1'] controllert=e2: trigger-arg-path: Binding >prep_with [lemma='k-ra'] themet+interceding-token ngrams: ) and transportedtbe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck1'] Gene_or_gene_productt'interceding-token ngrams: p-Gal-3 ) andt+interceding-token ngrams: is then recruitedt%interceding-token ngrams: ( p-Gal-3 )tGe2: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] themetXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] themet^e1: trigger-arg-path: Positive_regulation >agent [lemma='ck1'] controller:Gene_or_gene_productt!interceding-token ngrams: p-Gal-3t#interceding-token ngrams: p-Gal-3 )t\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation >agent [lemma='ck1'] Gene_or_gene_productt'interceding-token ngrams: membrane ( PMtUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck1'] controllert_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck1'] Gene_or_gene_productt)interceding-token ngrams: and transportedtRe2: trigger-arg-path: Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts:Binding >prep_with [lemma='k-ra'] Gene_or_gene_productt+interceding-token ngrams: plasma membrane (tTe2: trigger-arg-path: interacts >prep_with [lemma='k-ra'] theme:Gene_or_gene_producttYe1: trigger-arg-path: phosphorylated >agent [lemma='ck1'] controller:Gene_or_gene_productt?interceding-tokens-full-span: ( p-Gal-3 ) and transported to the cytosol . p-Gal-3 is then recruited to the plasma membrane ( PM ) wheret#interceding-token ngrams: cytosol .tge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] Gene_or_gene_producttXe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck1'] controllert&interceding-token ngrams: . p-Gal-3 ist+interceding-token ngrams: cytosol . p-Gal-3tinterceding-token ngrams: ( PMtje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='ck1'] controller:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck1'] Gene_or_gene_producttinterceding-token ngrams: PM )t$interceding-token ngrams: p-Gal-3 istie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck1'] controllert~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='ck1'] controller:Gene_or_gene_producttNe2: trigger-arg-path: interacts >prep_with [lemma='k-ra'] Gene_or_gene_productt(interceding-token ngrams: then recruitedt_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] Gene_or_gene_productt interceding-token ngrams: ( PM )tIe1: trigger-arg-path: Positive_regulation >agent [lemma='ck1'] controllert$interceding-token ngrams: PM ) wheret+interceding-token ngrams: then recruited tot#interceding-token ngrams: . p-Gal-3t,interceding-token ngrams: and transported tot*interceding-token ngrams: recruited to thet#interceding-token ngrams: ( p-Gal-3tme1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='ck1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: interacts >prep_with [lemma='k-ra'] themet)interceding-token ngrams: p-Gal-3 is thentme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='k-ra'] theme:Gene_or_gene_productt'interceding-token ngrams: the cytosol .tNe1: trigger-arg-path: phosphorylated >agent [lemma='ck1'] Gene_or_gene_productt&interceding-token ngrams: recruited totPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] themetinterceding-token ngrams: PMtLe2: trigger-arg-path: Binding >prep_with [lemma='k-ra'] Gene_or_gene_productt$interceding-token ngrams: membrane (tee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='k-ra'] theme:Gene_or_gene_producttXe1: trigger-arg-path: decreases:Negative_activation >nsubj >prep_of Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllertie1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of Gene_or_gene_producttDe1: trigger-arg-path: decreases:Negative_activation >dobj >nn Familyt;e1: trigger-arg-path: decreases >dobj >nn controlled:FamilytNe1: trigger-arg-path: decreases:Negative_activation >nsubj >prep_of controllertAe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj >nn Familyt?e1: trigger-arg-path: decreases:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productt,interceding-token ngrams: of Gal-3 increasest?interceding-tokens-full-span: activity while up regulation of Gal-3 increases Ras activity in pancreatic cancer cells . Using antibody array based screens and immunoprecipitation assays , we found thatt.e1: ents2Label-mention-ngram: SHARED decreasest5e1: ents2Label-mention-ngram: SHARED decreases SHAREDtTe1: trigger-arg-path: decreases >dobj [lemma='activity'] >nn [lemma='ra'] controlledt-interceding-token ngrams: while up regulationtee1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >nn [lemma='ra'] controlledt~e1: trigger-arg-path: Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_producttOe1: trigger-arg-path: decreases:Negative_activation >dobj >nn controlled:Familyt}e1: trigger-arg-path: decreases:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_productt-interceding-token ngrams: Gal-3 increases RastEe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj >nn controlledtte1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt+interceding-token ngrams: activity while upt4e1: trigger-arg-path: decreases >dobj >nn controlledtue1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] FamilytOe1: trigger-arg-path: decreases >nsubj >prep_of controller:Gene_or_gene_producttte1: trigger-arg-path: decreases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_producttie1: trigger-arg-path: decreases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_producttPe1: trigger-arg-path: decreases >dobj [lemma='activity'] >nn [lemma='ra'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_producttdobj >nn controlledt'interceding-token ngrams: up regulationtae1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >nn [lemma='ra'] FamilytDe1: trigger-arg-path: decreases >nsubj >prep_of Gene_or_gene_producttNe1: trigger-arg-path: Negative_activation >nsubj >prep_of Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledt:e1: trigger-arg-path: decreases >nsubj >prep_of controllert*CSSPATH: ROOT >ccomp >advcl ++ ROOT >ccompt1e1: args2Role-mention-ngram: decreases CONTROLLEDtoe1: trigger-arg-path: decreases:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_productt0interceding-token ngrams: increases Ras activityt^e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledtde1: trigger-arg-path: decreases:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familytce1: trigger-arg-path: decreases:Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >nn controlled:Familyt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:FamilytYe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >nn controlledtDe1: trigger-arg-path: Negative_activation >nsubj >prep_of controllertinterceding-token ngrams: upt[e1: trigger-arg-path: decreases >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt_e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj >prep_of controllertle1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familytee1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlled:Familyt_e1: trigger-arg-path: decreases >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert*interceding-token ngrams: up regulation oftse1: trigger-arg-path: Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj >nn controlled:Familyt.e1: ents2Label-mention-ngram: decreases SHAREDtYe1: trigger-arg-path: Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt)interceding-token ngrams: Gal-3 increasest?e1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllertse1: trigger-arg-path: decreases:Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert0e1: trigger-arg-path: decreases >dobj >nn FamilytUe1: trigger-arg-path: lemmatizedTrigger=decrease:Negative_activation >dobj >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controller:Gene_or_gene_productthe1: trigger-arg-path: decreases:Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] controlledtie1: trigger-arg-path: Negative_activation >nsubj [lemma='regulation'] >prep_of [lemma='gal-3'] controllert"interceding-token ngrams: while upt(interceding-token ngrams: activity whiletZe1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='ra'] Familyt\e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='socs1'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='transcription'] controlled:BioProcesst,e1: args2Role-mention-ngram: accumulation oft e1: args2Role-mention-ngram: boxt2e1: args2Role-mention-ngram: of phosphorylated p53tUe1: trigger-arg-path: Positive_activation >nsubj [lemma='socs1'] Gene_or_gene_productt#e1: ents2Label-mention-ngram: not at#e1: ents2Label-mention-ngram: , ledtge1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='socs1'] controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: not at"e1: args2Role-mention-ngram: , ledtHe1: trigger-arg-path: increased >dobj [lemma='transcription'] controlledt'interceding-token ngrams: STAT5 inducedtPe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj Familyt'e1: ents2Label-mention-ngram: but not at!e1: args2Role-mention-ngram: SOCSt3e1: ents2Label-mention-ngram: of phosphorylated p53tKe2: trigger-arg-path: reduced >nsubj [lemma='senescence'] controller:Familyt*e1: args2Role-mention-ngram: and increasedt_e2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='senescence'] controller:Familyt*e1: ents2Label-mention-ngram: not a mutantt)interceding-token ngrams: . The knockdownt_e1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='socs1'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj controller:Familytinterceding-token ngrams: STAT5t'interceding-token ngrams: gene p21CIP .tBe2: trigger-arg-path: Negative_regulation >nsubj controller:Familytme1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='transcription'] BioProcesst,e1: args2Role-mention-ngram: SOCS box domaint&e1: args2Role-mention-ngram: on serinet-e1: args2Role-mention-ngram: lacking the SOCStge1: trigger-arg-path: increased:Positive_activation >dobj [lemma='transcription'] controlled:BioProcesst#e1: args2Role-mention-ngram: p53 ontEe1: trigger-arg-path: increased:Positive_activation >nsubj controllertTe2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='senescence'] Familyt1e1: ents2Label-mention-ngram: to the accumulationt)interceding-token ngrams: of SOCS1 duringtee2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='senescence'] FamilytDe2: trigger-arg-path: reduced >nsubj [lemma='senescence'] controllert$interceding-token ngrams: p53 targett&e2: ents2Label-mention-ngram: on Ser15t.interceding-token ngrams: during STAT5 inducedt]e1: trigger-arg-path: Positive_activation >dobj [lemma='transcription'] controlled:BioProcesstOe1: trigger-arg-path: increased:Positive_activation >dobj controlled:BioProcesst`e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj controlled:BioProcesst%e1: args2Role-mention-ngram: the SOCSt&interceding-token ngrams: during STAT5t)e1: args2Role-mention-ngram: domain , ledt,e2: ents2Label-mention-ngram: FAMILY reducedt'interceding-token ngrams: The knockdownt#e2: ents2Label-mention-ngram: Ser15tVe1: trigger-arg-path: increased >nsubj [lemma='socs1'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: to the accumulationt+e1: args2Role-mention-ngram: mutant lackingtYe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='transcription'] controlledt`e1: trigger-arg-path: Positive_activation >nsubj [lemma='socs1'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: p53 on serinet1e1: ents2Label-mention-ngram: the accumulation oft0e2: ents2Label-mention-ngram: FAMILY reduced thetiinterceding-tokens-full-span: of the p53 target gene p21CIP . The knockdown of SOCS1 during STAT5 inducedt.e1: args2Role-mention-ngram: of phosphorylatedt)e1: args2Role-mention-ngram: on serine 15t?e2: trigger-arg-path: reduced:Negative_regulation >nsubj Familyt%e1: args2Role-mention-ngram: , led totPe2: trigger-arg-path: Negative_regulation >nsubj [lemma='senescence'] controllert&e1: ents2Label-mention-ngram: the SOCSt+e1: ents2Label-mention-ngram: serine 15 andt&e1: ents2Label-mention-ngram: , led totQe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='senescence'] Familyt&interceding-token ngrams: SOCS1 duringt\e2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='senescence'] controller:FamilytAe1: trigger-arg-path: increased >nsubj [lemma='socs1'] controllert*e1: ents2Label-mention-ngram: box domain ,tRe1: trigger-arg-path: Positive_activation >dobj [lemma='transcription'] controlledt-e1: ents2Label-mention-ngram: SOCS box domaintxe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='transcription'] controlled:BioProcesstnsubj controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: a mutant lackingtSe1: trigger-arg-path: increased >dobj [lemma='transcription'] controlled:BioProcesstKe1: trigger-arg-path: Positive_activation >nsubj [lemma='socs1'] controllertje1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='socs1'] controller:Gene_or_gene_productt'e1: args2Role-mention-ngram: led to thet!interceding-token ngrams: the p53tpe2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='senescence'] controller:FamilytKe1: trigger-arg-path: increased >nsubj [lemma='socs1'] Gene_or_gene_productt*e1: args2Role-mention-ngram: p53 on serinet$e1: ents2Label-mention-ngram: 15 andtDe1: trigger-arg-path: increased:Positive_activation >dobj BioProcesst+e2: trigger-arg-path: reduced >nsubj Familytpe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='socs1'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: accumulation oftAe1: trigger-arg-path: lemmatizedTrigger=increase >dobj BioProcesst{e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='socs1'] controller:Gene_or_gene_productt(interceding-token ngrams: the p53 targettJe2: trigger-arg-path: reduced:Negative_regulation >nsubj controller:Familyt"interceding-token ngrams: p21CIP .t2e1: ents2Label-mention-ngram: increased BIOPROCESStLe2: trigger-arg-path: Negative_regulation >nsubj [lemma='senescence'] Familyt\e1: trigger-arg-path: increased:Positive_activation >dobj [lemma='transcription'] BioProcesst0e1: args2Role-mention-ngram: the accumulation oft/e1: args2Role-mention-ngram: phosphorylated p53t&e1: args2Role-mention-ngram: serine 15tUe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj BioProcesst$e1: args2Role-mention-ngram: lackingtHe1: trigger-arg-path: increased >dobj [lemma='transcription'] BioProcesstme1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='transcription'] controlledt)e1: args2Role-mention-ngram: not a mutantt!e1: ents2Label-mention-ngram: boxt+e1: ents2Label-mention-ngram: and increasedt%e1: args2Role-mention-ngram: a mutantt7e2: trigger-arg-path: Negative_regulation >nsubj Familyt.e1: ents2Label-mention-ngram: the accumulationt)e1: args2Role-mention-ngram: the SOCS boxtUe1: trigger-arg-path: increased:Positive_activation >nsubj [lemma='socs1'] controllert5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ont*interceding-token ngrams: The knockdown oft,e1: ents2Label-mention-ngram: mutant lackingt"e1: ents2Label-mention-ngram: SOCSt&interceding-token ngrams: p21CIP . Thet)e1: ents2Label-mention-ngram: lacking thetLe1: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:BioProcesst(e1: ents2Label-mention-ngram: box domaint9e2: ents2Label-mention-ngram: reduced the phosphorylationt'e1: ents2Label-mention-ngram: serine 15t-e1: args2Role-mention-ngram: a mutant lackingt*e1: ents2Label-mention-ngram: domain , ledt6e2: trigger-arg-path: reduced >nsubj controller:Familyt.e1: ents2Label-mention-ngram: 15 and increasedt/e1: ents2Label-mention-ngram: of phosphorylatedt&e1: ents2Label-mention-ngram: a mutanttRe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='socs1'] controllert,interceding-token ngrams: target gene p21CIPtie2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj [lemma='senescence'] controllert%e1: ents2Label-mention-ngram: lackingt0e1: ents2Label-mention-ngram: phosphorylated p53t#e1: args2Role-mention-ngram: 15 andt*e1: ents2Label-mention-ngram: on serine 15t interceding-token ngrams: p21CIPt&e1: args2Role-mention-ngram: but not atDe1: trigger-arg-path: increased:Positive_activation >dobj controlledt*e1: args2Role-mention-ngram: serine 15 andt0e1: ents2Label-mention-ngram: mutant lacking thet)interceding-token ngrams: p53 target genet e1: ents2Label-mention-ngram: 15tYe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='transcription'] BioProcesstWe2: trigger-arg-path: Negative_regulation >nsubj [lemma='senescence'] controller:Familyt/e1: args2Role-mention-ngram: mutant lacking thet\e1: trigger-arg-path: increased:Positive_activation >dobj [lemma='transcription'] controlledt;e1: trigger-arg-path: increased >dobj controlled:BioProcesst%e1: args2Role-mention-ngram: domain ,t0e1: trigger-arg-path: increased >dobj BioProcesst'e1: args2Role-mention-ngram: box domaint%interceding-token ngrams: gene p21CIPt2e1: args2Role-mention-ngram: phosphorylated p53 ontOe1: trigger-arg-path: increased:Positive_activation >nsubj Gene_or_gene_productt$e1: ents2Label-mention-ngram: p53 ont&e1: ents2Label-mention-ngram: domain ,t.e1: ents2Label-mention-ngram: lacking the SOCSt@e2: trigger-arg-path: reduced >nsubj [lemma='senescence'] Familyt e1: args2Role-mention-ngram: ledt*e1: ents2Label-mention-ngram: the SOCS boxt-e1: args2Role-mention-ngram: the accumulationt%e1: args2Role-mention-ngram: SOCS boxtXe2: trigger-arg-path: reduced:Negative_regulation >nsubj [lemma='senescence'] controllertfe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='socs1'] controllert`e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj Gene_or_gene_productt$interceding-token ngrams: of the p53tke1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: and increased BIOPROCESSt;e1: args2Role-mention-ngram: accumulation of phosphorylatedt&e1: ents2Label-mention-ngram: SOCS boxt,interceding-token ngrams: knockdown of SOCS1tnsubj Familyt#e1: args2Role-mention-ngram: domaint,interceding-token ngrams: SOCS1 during STAT5t-e1: args2Role-mention-ngram: 15 and increasedt(e1: args2Role-mention-ngram: lacking thet5e1: args2Role-mention-ngram: and increased CONTROLLEDt3e1: ents2Label-mention-ngram: phosphorylated p53 ont#e1: args2Role-mention-ngram: led tot)e1: args2Role-mention-ngram: box domain ,t[e2: trigger-arg-path: lemmatizedTrigger=reduce:Negative_regulation >nsubj controller:FamilytUe2: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='senescence'] controllertRe1: trigger-arg-path: Positive_activation >dobj [lemma='transcription'] BioProcesste1: args2Role-mention-ngram: 15t;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT on Ser15t?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controller:Gene_or_gene_productt?e2: trigger-arg-path: increases >dobj [lemma='KRas'] controlledtTe2: trigger-arg-path: increases >dobj [lemma='KRas'] controlled:Gene_or_gene_producttIe2: trigger-arg-path: Negative_activation >dobj [lemma='KRas'] controlledt_e2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj >prep_of controllert/interceding-token ngrams: with this observationtje2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj controlled:Gene_or_gene_productt$interceding-token ngrams: decreasingtxe2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj [lemma='KRas'] controlledtJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='KRas'] themetye2: trigger-arg-path: increases >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Negative_activation >dobj [lemma='KRas'] controlled:Gene_or_gene_productt/interceding-token ngrams: decreasing activitiestce2: trigger-arg-path: increases:Negative_activation >nsubj >prep_of controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj [lemma='KRas'] controlled:Gene_or_gene_productt2interceding-token ngrams: decreasing activities oftEe2: trigger-arg-path: increases >dobj controlled:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=increase >dobj Gene_or_gene_productt+interceding-token ngrams: In agreement withtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='KRas'] themet:e2: trigger-arg-path: increases >dobj Gene_or_gene_producttHe1: trigger-arg-path: binds >prep_to [lemma='KRas'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controller:Gene_or_gene_producttXe2: trigger-arg-path: increases:Negative_activation >nsubj >prep_of Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='KRas'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj >prep_of controller:Gene_or_gene_producttxe2: trigger-arg-path: increases:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controllertNe1: trigger-arg-path: binds >prep_to [lemma='KRas'] theme:Gene_or_gene_productt*interceding-token ngrams: this observationte2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] Gene_or_gene_productt!interceding-token ngrams: Raf andt-interceding-token ngrams: agreement with thisthe2: trigger-arg-path: increases:Negative_activation >dobj [lemma='KRas'] controlled:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='KRas'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='KRas'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] Gene_or_gene_producttSe2: trigger-arg-path: increases:Negative_activation >dobj [lemma='KRas'] controlledt7interceding-token ngrams: thereby decreasing activitiest(interceding-token ngrams: agreement withtde2: trigger-arg-path: increases >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controllertNe2: trigger-arg-path: increases:Negative_activation >dobj Gene_or_gene_productt]e2: trigger-arg-path: increases:Negative_activation >dobj [lemma='KRas'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_to [lemma='KRas'] theme:Gene_or_gene_productt"interceding-token ngrams: ERK . IntYe2: trigger-arg-path: increases:Negative_activation >dobj controlled:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj Gene_or_gene_productt&interceding-token ngrams: In agreementt;e1: trigger-arg-path: Binding >prep_to [lemma='KRas'] themetYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='KRas'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >prep_to [lemma='KRas'] themet?e2: trigger-arg-path: increases:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=increase >dobj controlled:Gene_or_gene_producttne2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controllert+interceding-token ngrams: activities of Raftne2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj [lemma='KRas'] Gene_or_gene_productt%interceding-token ngrams: Raf and ERKtIe2: trigger-arg-path: increases >dobj [lemma='KRas'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='KRas'] controlledt(interceding-token ngrams: . In agreementt interceding-token ngrams: of Raft.interceding-token ngrams: , thereby decreasingtUe2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >dobj controlledtZe2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='KRas'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='KRas'] controlled:Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >prep_to [lemma='KRas'] theme:Gene_or_gene_productt?e2: trigger-arg-path: increases:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controller:Gene_or_gene_producttSe2: trigger-arg-path: Negative_activation >dobj [lemma='KRas'] Gene_or_gene_productt?interceding-tokens-full-span: , thereby decreasing activities of Raf and ERK . In agreement with this observation , inhibition oft#interceding-token ngrams: with thistue2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controllert$interceding-token ngrams: of Raf andtne2: trigger-arg-path: increases >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] Gene_or_gene_productt#interceding-token ngrams: agreementt,interceding-token ngrams: thereby decreasingt'interceding-token ngrams: observation ,tDe2: trigger-arg-path: increases:Negative_activation >dobj controlledt'interceding-token ngrams: activities oftge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='KRas'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='KRas'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controllert2interceding-token ngrams: observation , inhibitiontNe2: trigger-arg-path: increases:Negative_activation >nsubj >prep_of controllert?e2: trigger-arg-path: Negative_activation >nsubj [lemma='inhibition'] >prep_of [lemma='calmodulin'] controller:Gene_or_gene_productt,interceding-token ngrams: this observation ,t9e1: trigger-arg-path: binds >prep_to [lemma='KRas'] themetke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='chmp6'] theme:Gene_or_gene_producttKe2: trigger-arg-path: binding >prep_of [lemma='vps4a'] Gene_or_gene_productt(e1: args2Role-mention-ngram: K-Ras , cantMe1: trigger-arg-path: Binding >prep_with [lemma='chmp6'] Gene_or_gene_producttDe2: trigger-arg-path: binding:Binding >prep_of [lemma='chmp6'] themetnsubjpass [lemma='h-ras'] Gene_or_gene_producttTe1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='chmp6'] themetce1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='h-ras'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >nsubjpass [lemma='h-ras'] theme:Gene_or_gene_productt9e1: args2Role-mention-ngram: can be co-immunoprecipitatedt>e1: trigger-arg-path: Binding >nsubjpass [lemma='h-ras'] themet*e1: args2Role-mention-ngram: but not K-Rast#e1: args2Role-mention-ngram: can betce1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='chmp6'] Gene_or_gene_productt:e1: args2Role-mention-ngram: be co-immunoprecipitated withtNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='vps4a'] themetprep_of [lemma='chmp6'] themetTe1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='h-ras'] themet'e1: ents2Label-mention-ngram: not K-RastQe2: trigger-arg-path: Binding >prep_of [lemma='chmp6'] theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='h-ras'] Gene_or_gene_productt>e1: trigger-arg-path: Binding >prep_with [lemma='chmp6'] themetze1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='h-ras'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='chmp6'] theme:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='chmp6'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='chmp6'] Gene_or_gene_producttYe2: trigger-arg-path: binding:Binding >prep_of [lemma='vps4a'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: N-Ras , buttSe2: trigger-arg-path: binding:Binding >prep_of [lemma='chmp6'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='vps4a'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: be co-immunoprecipitatedtprep_of [lemma='vps4a'] themetie1: trigger-arg-path: co-immunoprecipitated:Binding >prep_with [lemma='chmp6'] theme:Gene_or_gene_productt$e1: args2Role-mention-ngram: K-Ras ,t$interceding-token ngrams: or VPS4A .tDe2: trigger-arg-path: binding:Binding >prep_of [lemma='vps4a'] themet%e1: ents2Label-mention-ngram: K-Ras ,tSe2: trigger-arg-path: binding:Binding >prep_of [lemma='vps4a'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: N-Ras ,t:e1: ents2Label-mention-ngram: can be co-immunoprecipitatedt$e1: args2Role-mention-ngram: N-Ras ,tae1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='chmp6'] theme:Gene_or_gene_productt[e1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='h-ras'] Gene_or_gene_producttinterceding-token ngrams: VPS4At!interceding-token ngrams: VPS4A .t"interceding-token ngrams: or VPS4At&e1: args2Role-mention-ngram: and N-Rast5e1: args2Role-mention-ngram: be co-immunoprecipitatedtVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='chmp6'] themetJinterceding-tokens-full-span: or VPS4A . These data suggest that efficientt&interceding-token ngrams: . These datat[e1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='chmp6'] Gene_or_gene_productt#interceding-token ngrams: efficientt+interceding-token ngrams: data suggest thatt%e1: args2Role-mention-ngram: , can bet]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='vps4a'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: and N-Ras ,t(e1: args2Role-mention-ngram: N-Ras , butt'e1: ents2Label-mention-ngram: and N-Rast'interceding-token ngrams: VPS4A . ThesetQe2: trigger-arg-path: binding >prep_of [lemma='vps4a'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='chmp6'] Gene_or_gene_producttYe2: trigger-arg-path: binding:Binding >prep_of [lemma='chmp6'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='h-ras'] themet&e1: ents2Label-mention-ngram: , can betprep_of [lemma='chmp6'] themetce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='vps4a'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >nsubjpass [lemma='h-ras'] theme:Gene_or_gene_productt$interceding-token ngrams: These datat+e1: ents2Label-mention-ngram: but not K-Rast"e1: args2Role-mention-ngram: N-Rastke2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='vps4a'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: not K-Ras ,t]e1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='chmp6'] themetze1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='chmp6'] theme:Gene_or_gene_producttLe1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='h-ras'] themetie1: trigger-arg-path: co-immunoprecipitated:Binding >nsubjpass [lemma='h-ras'] theme:Gene_or_gene_productt;e1: ents2Label-mention-ngram: be co-immunoprecipitated witht(e1: args2Role-mention-ngram: and N-Ras ,t)e1: ents2Label-mention-ngram: K-Ras , cantprep_of [lemma='vps4a'] themet#e1: ents2Label-mention-ngram: N-Rast&e1: args2Role-mention-ngram: not K-Rastee1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >nsubjpass [lemma='h-ras'] themetVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='vps4a'] themet0interceding-token ngrams: suggest that efficienttQe2: trigger-arg-path: Binding >prep_of [lemma='vps4a'] theme:Gene_or_gene_producttSe1: trigger-arg-path: Binding >prep_with [lemma='chmp6'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_of [lemma='chmp6'] Gene_or_gene_productt,interceding-token ngrams: These data suggesttKe2: trigger-arg-path: binding >prep_of [lemma='chmp6'] Gene_or_gene_productt"e1: args2Role-mention-ngram: K-RastQe2: trigger-arg-path: binding >prep_of [lemma='chmp6'] theme:Gene_or_gene_productt(interceding-token ngrams: that efficienttLe1: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='chmp6'] themet$e1: ents2Label-mention-ngram: can bet#e1: ents2Label-mention-ngram: K-Rastae1: trigger-arg-path: co-immunoprecipitated >nsubjpass [lemma='h-ras'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: THEME and N-Rastee1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='chmp6'] themet&interceding-token ngrams: data suggesttNe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='chmp6'] themet(e1: args2Role-mention-ngram: not K-Ras ,tKe2: trigger-arg-path: Binding >prep_of [lemma='vps4a'] Gene_or_gene_producttMe1: trigger-arg-path: Binding >nsubjpass [lemma='h-ras'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='chmp6'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='chmp6'] Gene_or_gene_producttKe2: trigger-arg-path: mediated:Positive_activation >nsubj controller:FamilytUe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] controller:FamilytXe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj >nn controlledt=e2: trigger-arg-path: mediated >nsubj [lemma='ra'] controllertle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_producttQe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='ra'] controllertinterceding-token ngrams: PLCtme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt)interceding-token ngrams: activation , wet,interceding-token ngrams: 2+ influx enhancedt interceding-token ngrams: that at)interceding-token ngrams: , we speculatedt interceding-token ngrams: influxtge2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='activation'] >nn [lemma='erk'] controlledtNe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj >nn Gene_or_gene_productt&interceding-token ngrams: enhanced thet\e2: trigger-arg-path: mediated:Positive_activation >dobj >nn controlled:Gene_or_gene_productt)interceding-token ngrams: EGF induced ERKt$interceding-token ngrams: speculatedtJe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] Familyt(interceding-token ngrams: increase in Cat?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttke2: trigger-arg-path: mediated >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: mediated >dobj >nn controlled:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj Familytje2: trigger-arg-path: mediated:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledt|e2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj >nn controlledt3e2: trigger-arg-path: mediated >dobj >nn controlledtfe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt-interceding-token ngrams: inhibit EGF inducedt4e2: ents2Label-mention-ngram: FAMILY mediated SHAREDt=e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj Familyt?interceding-tokens-full-span: to ca. 50 % of the control . Because a PKC inhibitor Go6983 did not inhibit EGF induced ERK activation , we speculated that a PLC mediated increase in Ca 2+ influx enhanced thet=e2: trigger-arg-path: mediated >dobj >nn Gene_or_gene_producttSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_productt[e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] Gene_or_gene_producttQe2: trigger-arg-path: mediated:Positive_activation >dobj >nn Gene_or_gene_productt(interceding-token ngrams: a PLC mediatedtbe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj >nn Gene_or_gene_productt)interceding-token ngrams: influx enhancedtinterceding-token ngrams: in Cat,e2: trigger-arg-path: mediated >nsubj Familyt^e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] Familyt-interceding-token ngrams: influx enhanced thet)interceding-token ngrams: not inhibit EGFtte2: trigger-arg-path: mediated:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttGe2: trigger-arg-path: mediated:Positive_activation >dobj >nn controlledtAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induced SHAREDt.interceding-token ngrams: mediated increase intinterceding-token ngrams: a PLCt,interceding-token ngrams: we speculated thatt%interceding-token ngrams: inhibit EGFt)interceding-token ngrams: speculated thatt+interceding-token ngrams: mediated increasetie2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] controller:Familyt'interceding-token ngrams: we speculatedt@e2: trigger-arg-path: mediated:Positive_activation >nsubj Familyt{e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlledtqe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt&interceding-token ngrams: Ca 2+ influxt*interceding-token ngrams: ERK activation ,t^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] controller:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj controller:FamilytXe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='ra'] controller:FamilytDe2: trigger-arg-path: mediated >nsubj [lemma='ra'] controller:Familyt&interceding-token ngrams: PLC mediatedtIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='egf'] controllert`e2: trigger-arg-path: mediated >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt"interceding-token ngrams: in Ca 2+t$interceding-token ngrams: that a PLCt7e2: trigger-arg-path: mediated >nsubj controller:Familyt9e2: trigger-arg-path: mediated >nsubj [lemma='ra'] FamilytHe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt8CSSPATH: ROOT >ccomp >ccomp ++ ROOT >ccomp >ccomp >ccomptNe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ra'] controllert#interceding-token ngrams: 2+ influxt+interceding-token ngrams: speculated that atMe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='ra'] FamilytYe2: trigger-arg-path: lemmatizedTrigger=mediate >dobj >nn controlled:Gene_or_gene_productte2: trigger-arg-path: mediated:Positive_activation >dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttQe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='egf'] controllertbe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='ra'] controllert/interceding-token ngrams: PLC mediated increasetVe2: trigger-arg-path: mediated >dobj [lemma='activation'] >nn [lemma='erk'] controlledtbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='egf'] controllert(interceding-token ngrams: The results oftinterceding-token ngrams: ~t.e2: ents2Label-mention-ngram: SHARED or SHAREDtinterceding-token ngrams: nexttJe2: trigger-arg-path: Binding >nn [lemma='cbp'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: physically associated witht%interceding-token ngrams: exhibited at%e1: args2Role-mention-ngram: affectedtGe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='cbp'] themet+e1: args2Role-mention-ngram: CBP physicallytSe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with Generic_entitytje1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='p300'] theme:Gene_or_gene_productt$interceding-token ngrams: results oft&e1: ents2Label-mention-ngram: affectedt5e2: trigger-arg-path: binding >nn [lemma='cbp'] themetQe1: trigger-arg-path: associated >nsubj [lemma='p300'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='gene'] Generic_entityt#interceding-token ngrams: performedt*interceding-token ngrams: demonstrate thatt-e1: ents2Label-mention-ngram: affected SHAREDtWe1: trigger-arg-path: associated:Binding >prep_with [lemma='gene'] theme:Generic_entityt'e2: ents2Label-mention-ngram: or SHAREDt6e1: args2Role-mention-ngram: CBP physically associatedt)interceding-token ngrams: ChIP analysis .t.interceding-token ngrams: genes that exhibitedtYe1: trigger-arg-path: associated:Binding >nsubj [lemma='p300'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with theme:Generic_entityt%interceding-token ngrams: demonstratet5e1: trigger-arg-path: associated:Binding >nsubj themet.e1: args2Role-mention-ngram: with the affectedt`e1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='gene'] theme:Generic_entityt6e2: trigger-arg-path: binding >nn [lemma='p300'] themet7e1: trigger-arg-path: Binding >prep_with Generic_entityt*interceding-token ngrams: performed a ChIPtDe1: trigger-arg-path: associated:Binding >nsubj Gene_or_gene_productt$interceding-token ngrams: analysis .t+e1: args2Role-mention-ngram: affected THEMEt"interceding-token ngrams: Ras-PI3Kt*e1: ents2Label-mention-ngram: the affectedtRe2: trigger-arg-path: binding:Binding >nn [lemma='cbp'] theme:Gene_or_gene_productt(interceding-token ngrams: a reduction int(interceding-token ngrams: next performedtnsubj [lemma='p300'] themet1interceding-token ngrams: experiments demonstratetIe1: trigger-arg-path: associated >prep_with [lemma='gene'] Generic_entityt3interceding-token ngrams: exhibited reduced H3K56act,interceding-token ngrams: following Ras-PI3Kt-e1: trigger-arg-path: associated >nsubj themet(interceding-token ngrams: that exhibitedt/e1: args2Role-mention-ngram: the affected THEMEtQe1: trigger-arg-path: associated:Binding >prep_with [lemma='gene'] Generic_entitytEe2: trigger-arg-path: Binding >nn [lemma='p300'] Gene_or_gene_productt2interceding-token ngrams: Ras-PI3K activation alsot/interceding-token ngrams: exhibited a reductiont)interceding-token ngrams: reduced H3K56act+interceding-token ngrams: H3K56ac followingtbe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='p300'] theme:Gene_or_gene_productt+interceding-token ngrams: exhibited reducedtBe1: trigger-arg-path: associated >nsubj theme:Gene_or_gene_producttDe2: trigger-arg-path: binding >nn [lemma='cbp'] Gene_or_gene_productt%e2: args2Role-mention-ngram: or THEMEtQe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='gene'] themet@e1: trigger-arg-path: associated >prep_with [lemma='gene'] themet interceding-token ngrams: that ~t interceding-token ngrams: ~ 70 %tKe2: trigger-arg-path: Binding >nn [lemma='p300'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='cbp'] theme:Gene_or_gene_producttKe2: trigger-arg-path: binding >nn [lemma='p300'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: and CBP physicallytDe1: trigger-arg-path: associated:Binding >nsubj [lemma='p300'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='p300'] themetMe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='p300'] themet%interceding-token ngrams: The resultstJe2: trigger-arg-path: binding >nn [lemma='cbp'] theme:Gene_or_gene_productt'interceding-token ngrams: . The resultstJe1: trigger-arg-path: associated:Binding >nsubj theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: or THEME bindingt$interceding-token ngrams: genes thattinterceding-token ngrams: 70 %tHe1: trigger-arg-path: Binding >nsubj [lemma='p300'] Gene_or_gene_producttHe1: trigger-arg-path: associated:Binding >prep_with [lemma='gene'] themet*interceding-token ngrams: results of thesetLe2: trigger-arg-path: binding:Binding >nn [lemma='cbp'] Gene_or_gene_productt!interceding-token ngrams: 70 % oftMe2: trigger-arg-path: binding:Binding >nn [lemma='p300'] Gene_or_gene_producttinterceding-token ngrams: 70t+e2: args2Role-mention-ngram: THEME or THEMEt)interceding-token ngrams: activation alsot&interceding-token ngrams: reduction int*interceding-token ngrams: the tested genest,interceding-token ngrams: demonstrate that ~tBe1: trigger-arg-path: associated:Binding >prep_with Generic_entityt0interceding-token ngrams: that exhibited reducedt/e1: ents2Label-mention-ngram: with the affectedtKe1: trigger-arg-path: associated >nsubj [lemma='p300'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p300'] themet3CSSPATH: ROOT >advcl >ccomp ++ ROOT >ccomp >prep_intUe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='p300'] themet@e1: trigger-arg-path: associated >prep_with theme:Generic_entityt3e1: ents2Label-mention-ngram: physically associatedt5e2: trigger-arg-path: Binding >nn [lemma='cbp'] themet6e2: trigger-arg-path: Binding >nn [lemma='p300'] themet/e2: ents2Label-mention-ngram: or SHARED bindingtOe1: trigger-arg-path: associated >prep_with [lemma='gene'] theme:Generic_entityt-interceding-token ngrams: Ras-PI3K activationtQe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with theme:Generic_entityt3interceding-token ngrams: activation also exhibitedt0e1: ents2Label-mention-ngram: and CBP physicallyt)interceding-token ngrams: a ChIP analysist,e1: ents2Label-mention-ngram: CBP physicallyt*interceding-token ngrams: next performed at&interceding-token ngrams: tested genest7e1: args2Role-mention-ngram: physically associated withtYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='gene'] themet interceding-token ngrams: a ChIPtNe1: trigger-arg-path: Binding >nsubj [lemma='p300'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='gene'] themet^e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='cbp'] Gene_or_gene_productt3interceding-token ngrams: reduced H3K56ac followingt>e2: trigger-arg-path: binding:Binding >nn [lemma='p300'] themet7e1: ents2Label-mention-ngram: CBP physically associatedtKe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with Generic_entityt+interceding-token ngrams: tested genes thatthe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='gene'] theme:Generic_entityt7interceding-token ngrams: following Ras-PI3K activationt(interceding-token ngrams: analysis . Thet*interceding-token ngrams: also exhibited atee2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p300'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: physically associatedt$interceding-token ngrams: the testedt!interceding-token ngrams: H3K56act:e1: trigger-arg-path: associated >prep_with Generic_entityt_e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p300'] Gene_or_gene_productt'interceding-token ngrams: of the testedtbe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='gene'] Generic_entitytde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='cbp'] theme:Gene_or_gene_producttHe1: trigger-arg-path: associated:Binding >prep_with theme:Generic_entityt!interceding-token ngrams: we nexttFe1: trigger-arg-path: Binding >prep_with [lemma='gene'] Generic_entityt\e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='p300'] Gene_or_gene_productt*e1: args2Role-mention-ngram: THEME and CBPt+interceding-token ngrams: we next performedtEe2: trigger-arg-path: binding >nn [lemma='p300'] Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='cbp'] Gene_or_gene_productt(interceding-token ngrams: also exhibitedtinterceding-token ngrams: ~ 70tWe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p300'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='cbp'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='p300'] Gene_or_gene_producttSe2: trigger-arg-path: binding:Binding >nn [lemma='p300'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='p300'] themet.interceding-token ngrams: of these experimentst7interceding-token ngrams: these experiments demonstratet#interceding-token ngrams: exhibitedtSe1: trigger-arg-path: associated:Binding >nsubj [lemma='p300'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: the affected SHAREDt?interceding-tokens-full-span: , we next performed a ChIP analysis . The results of these experiments demonstrate that ~ 70 % of the tested genes that exhibited reduced H3K56ac following Ras-PI3K activation also exhibited a reduction int%interceding-token ngrams: a reductiont+interceding-token ngrams: these experimentst=e2: trigger-arg-path: binding:Binding >nn [lemma='cbp'] themet#interceding-token ngrams: , we nextt'interceding-token ngrams: ChIP analysistLe1: trigger-arg-path: Binding >prep_with [lemma='gene'] theme:Generic_entityt#interceding-token ngrams: that ~ 70t interceding-token ngrams: testedt)e1: args2Role-mention-ngram: the affectedt6interceding-token ngrams: experiments demonstrate thattOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='cbp'] themet%interceding-token ngrams: performed at]e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='p300'] theme:Gene_or_gene_productt4interceding-token ngrams: H3K56ac following Ras-PI3KtYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with theme:Generic_entitytnsubj Gene_or_gene_productt'interceding-token ngrams: also triggerst\e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='protein'] themet8e2: args2Role-mention-ngram: the acetyltransferase THEMEt@e1: trigger-arg-path: Positive_activation >nsubj >prep_of Familyt7e2: ents2Label-mention-ngram: and the acetyltransferasetTe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='protein'] themetfe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='senescence'] >nn [lemma='pml'] controlledtie2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='protein'] theme:Gene_or_gene_producttJe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='protein'] themetbe1: trigger-arg-path: Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] Familyt"interceding-token ngrams: triggerst+interceding-token ngrams: Ras also triggerst-interceding-token ngrams: mediated senescencetde1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of controller:Familyt)interceding-token ngrams: senescence in at'interceding-token ngrams: senescence intke1: trigger-arg-path: Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] Gene_or_gene_producttYe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='protein'] Gene_or_gene_producttje1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] Familyt&interceding-token ngrams: manner . RastAe1: ents2Label-mention-ngram: FAMILY induces GENE_OR_GENE_PRODUCTtpe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='senescence'] >nn [lemma='pml'] Gene_or_gene_productt:e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and thetHe1: trigger-arg-path: induces:Positive_activation >nsubj >prep_of Familytse1: trigger-arg-path: induces:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='protein'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] Gene_or_gene_producttKe1: trigger-arg-path: Positive_activation >nsubj >prep_of controller:Familytje1: trigger-arg-path: induces >dobj [lemma='senescence'] >nn [lemma='pml'] controlled:Gene_or_gene_producttie1: trigger-arg-path: induces:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlledtSe1: trigger-arg-path: induces:Positive_activation >nsubj >prep_of controller:Familyt4e1: trigger-arg-path: induces >nsubj >prep_of Familyt_e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='protein'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='ra'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controller:Familyt,e1: ents2Label-mention-ngram: FAMILY induceste1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controllert?e1: trigger-arg-path: induces >nsubj >prep_of controller:Familytge1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='ra'] FamilytEe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of Familyt2e2: args2Role-mention-ngram: the acetyltransferasetZe1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='ra'] controllert$interceding-token ngrams: . Ras alsotze1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlledt:e1: ents2Label-mention-ngram: induces GENE_OR_GENE_PRODUCTtPe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of controller:Familyt0interceding-token ngrams: mediated senescence int4e2: args2Role-mention-ngram: acetyltransferase THEMEtBe2: trigger-arg-path: recruitment >prep_of [lemma='protein'] themet*e2: args2Role-mention-ngram: THEME and thetke2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='protein'] Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='senescence'] >nn [lemma='pml'] controlled:Gene_or_gene_producttinterceding-token ngrams: . Rastfe1: trigger-arg-path: Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controllert_interceding-tokens-full-span: mediated senescence in a p53 dependent manner . Ras also triggerst{e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] FamilytWe2: trigger-arg-path: recruitment >prep_of [lemma='protein'] theme:Gene_or_gene_producttue1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controller:Familytae1: trigger-arg-path: Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlledt6e2: args2Role-mention-ngram: and the acetyltransferasetHe2: ents2Label-mention-ngram: the acetyltransferase GENE_OR_GENE_PRODUCTtve1: trigger-arg-path: Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlled:Gene_or_gene_productt~e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of FamilytLe1: trigger-arg-path: induces:Positive_activation >nsubj >prep_of controllertUe1: trigger-arg-path: induces >dobj [lemma='senescence'] >nn [lemma='pml'] controlledtne1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controllert3e2: ents2Label-mention-ngram: the acetyltransferasetce2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='protein'] Gene_or_gene_producttDe2: ents2Label-mention-ngram: acetyltransferase GENE_OR_GENE_PRODUCTt"interceding-token ngrams: Ras alsot_e1: trigger-arg-path: induces >dobj [lemma='senescence'] >nn [lemma='pml'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='ra'] controller:Familyt]e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='senescence'] >nn [lemma='pml'] controlled:Gene_or_gene_producttme1: trigger-arg-path: Positive_activation >nsubj [lemma='expression'] >prep_of [lemma='ra'] controller:FamilytQe2: trigger-arg-path: recruitment >prep_of [lemma='protein'] Gene_or_gene_producttae1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='ra'] controller:FamilytVe1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='ra'] FamilytMe2: trigger-arg-path: complexes >nn [lemma='cdk4'] theme:Gene_or_gene_producttOe2: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] Gene_or_gene_producttYe2: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] Familyt@e1: trigger-arg-path: complex:Binding nn theme:Familyt#interceding-token ngrams: family istPe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] themetge1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] theme:FamilytUCSSPATH: ROOT >dobj >prepc_in >dep >prepc_from >dobj ++ ROOT >prepc_in >dobj >prep_oft*interceding-token ngrams: more interestingtKe1: trigger-arg-path: complex >nn [lemma='cdk2'] theme:Gene_or_gene_productt!interceding-token ngrams: and Kipt.interceding-token ngrams: interesting role fort1e1: trigger-arg-path: complex nn themetQe2: trigger-arg-path: complexes nn [lemma='cyclin'] Familyt:e2: trigger-arg-path: complexes nn theme:Familyt%interceding-token ngrams: Cip and Kipt%interceding-token ngrams: for the CiptNe1: trigger-arg-path: Binding nn [lemma='cyclin'] themet#interceding-token ngrams: . Anothert%interceding-token ngrams: the Cip andt&interceding-token ngrams: family is intGe2: trigger-arg-path: complexes >nn [lemma='cdk4'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] FamilytOe1: trigger-arg-path: complex nn [lemma='cyclin'] FamilytOe1: trigger-arg-path: Binding nn [lemma='cyclin'] Familyt>e1: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] themet!interceding-token ngrams: the Cipt/interceding-token ngrams: more interesting roletUe2: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >nn [lemma='cdk2'] theme:Gene_or_gene_productt:e1: trigger-arg-path: complex:Binding nn Familyt9e1: trigger-arg-path: complex:Binding nn themetvinterceding-tokens-full-span: . Another more interesting role for the Cip and Kip family is in aiding the formation oft_e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] Gene_or_gene_productt6e1: trigger-arg-path: Binding >nn [lemma='cdk2'] themetoe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] theme:FamilytNe1: trigger-arg-path: complex nn [lemma='cyclin'] themet_e2: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] theme:Familyt"interceding-token ngrams: role fort#interceding-token ngrams: in aidingt8e1: trigger-arg-path: complex nn theme:Familyt&interceding-token ngrams: role for thetnn FamilytEe1: trigger-arg-path: complex >nn [lemma='cdk2'] Gene_or_gene_productt]e1: trigger-arg-path: complex:Binding nn [lemma='cyclin'] theme:Familyt4e2: trigger-arg-path: complexes nn FamilytMe1: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] Gene_or_gene_productt(interceding-token ngrams: and Kip familyt'interceding-token ngrams: Kip family istWe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] Gene_or_gene_productt interceding-token ngrams: aidingtae1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] Familyt3e2: trigger-arg-path: complexes nn themetUe1: trigger-arg-path: complex nn [lemma='cyclin'] theme:FamilytVe1: trigger-arg-path: complex:Binding nn [lemma='cyclin'] themetinterceding-token ngrams: is int(interceding-token ngrams: . Another morethe1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='cyclin'] themetXe2: trigger-arg-path: complexes:Binding nn [lemma='cyclin'] themet&interceding-token ngrams: Another moret2interceding-token ngrams: Another more interestingtBe2: trigger-arg-path: complexes:Binding nn theme:Familyt&interceding-token ngrams: is in aidingtHe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] themet*interceding-token ngrams: interesting rolet;e2: trigger-arg-path: complexes:Binding nn themet2e1: trigger-arg-path: complex nn FamilytSe1: trigger-arg-path: complex:Binding >nn [lemma='cdk2'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cdk2'] theme:Gene_or_gene_productt'interceding-token ngrams: in aiding thetinterceding-token ngrams: Cipt$interceding-token ngrams: Kip familyt6e1: trigger-arg-path: complex >nn [lemma='cdk2'] themet]e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cdk2'] theme:Gene_or_gene_producttWe1: trigger-arg-path: complex:Binding nn [lemma='cyclin'] Familyt8e2: trigger-arg-path: complexes >nn [lemma='cdk4'] themet`e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='cyclin'] themetUe1: trigger-arg-path: Binding nn [lemma='cyclin'] theme:Familyt!interceding-token ngrams: Anothert.interceding-token ngrams: aiding the formationtEe1: trigger-arg-path: Binding >nn [lemma='cdk2'] Gene_or_gene_productt@e2: trigger-arg-path: complexes:Binding >nn [lemma='cdk4'] themetWe2: trigger-arg-path: complexes nn [lemma='cyclin'] theme:FamilytPe2: trigger-arg-path: complexes nn [lemma='cyclin'] themet$interceding-token ngrams: aiding thet!interceding-token ngrams: Cip andtinterceding-token ngrams: Kipt?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controller:Gene_or_gene_productt^e2: trigger-arg-path: induce:Positive_regulation >nsubj >prep_of >prep_of Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of >prep_of Gene_or_gene_productt3e2: ents2Label-mention-ngram: induce a dissociationt.e2: args2Role-mention-ngram: a dissociation oft?e2: trigger-arg-path: induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] Gene_or_gene_productt?e2: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controllert(e2: ents2Label-mention-ngram: not inducetTe2: trigger-arg-path: induce:Positive_regulation >nsubj >prep_of >prep_of controllertge2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of >prep_of controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: not inducetJe2: trigger-arg-path: induce >nsubj >prep_of >prep_of Gene_or_gene_productt/e2: ents2Label-mention-ngram: a dissociation oftbe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_of controller:Gene_or_gene_producttMe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_of controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of >prep_of controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: not induce at?e2: trigger-arg-path: induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controller:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of >prep_of controllert-e2: ents2Label-mention-ngram: does not inducet?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controllertRe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj >prep_of >prep_of controllert2e2: args2Role-mention-ngram: induce a dissociationtinterceding-tokens-full-span: through a region of the phosphatase termed kinase interaction motif ( KIM ) . Interestingly , this interaction is independent of the phosphorylation status of ERK and its kinase activity , as phosphorylation of the activating residues oftze2: trigger-arg-path: induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controllert?e2: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: does not inducet?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controllert,e2: ents2Label-mention-ngram: a dissociationt+e2: args2Role-mention-ngram: a dissociationtie2: trigger-arg-path: induce:Positive_regulation >nsubj >prep_of >prep_of controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: induce atUe2: trigger-arg-path: induce >nsubj >prep_of >prep_of controller:Gene_or_gene_producttWe2: trigger-arg-path: Positive_regulation >nsubj >prep_of >prep_of Gene_or_gene_productt?e2: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] Gene_or_gene_productt@e2: trigger-arg-path: induce >nsubj >prep_of >prep_of controllert)e2: args2Role-mention-ngram: not induce at?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj >prep_of >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='residue'] >prep_of [lemma='erk'] controllert&e2: ents2Label-mention-ngram: induce atYe2: trigger-arg-path: phosphorylated >agent [lemma='akt'] controller:Gene_or_gene_producttDe1: trigger-arg-path: interacts:Binding >nsubj [lemma='GSK-3'] themetDe2: trigger-arg-path: phosphorylated >agent [lemma='akt'] controllert#interceding-token ngrams: Akt has at!interceding-token ngrams: TSC2 tot)interceding-token ngrams: regulate mTORC1t"interceding-token ngrams: GSK-3 ast%interceding-token ngrams: on GSK-3 ast,e1: args2Role-mention-ngram: with both THEMEt[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='akt'] theme:Gene_or_gene_productt&interceding-token ngrams: mTORC1 . Aktt0e1: args2Role-mention-ngram: interacts with bothtje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='akt'] controller:Gene_or_gene_producttnsubj [lemma='GSK-3'] themetSe2: trigger-arg-path: Positive_regulation >agent [lemma='akt'] Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >agent [lemma='akt'] controllert#interceding-token ngrams: , TSC2 tot"interceding-token ngrams: on GSK-3t'e1: ents2Label-mention-ngram: with bothtKe1: trigger-arg-path: interacts >nsubj [lemma='GSK-3'] Gene_or_gene_productt*interceding-token ngrams: TSC2 to regulatet$interceding-token ngrams: a negativet"interceding-token ngrams: mTORC1 .tYe1: trigger-arg-path: interacts:Binding >nsubj [lemma='GSK-3'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='akt'] themetUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='akt'] controllertinterceding-token ngrams: . Akttme2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] controller:Gene_or_gene_producttNe2: trigger-arg-path: phosphorylated >agent [lemma='akt'] Gene_or_gene_producttSe1: trigger-arg-path: interacts >prep_with [lemma='akt'] theme:Gene_or_gene_producttQe1: trigger-arg-path: interacts >nsubj [lemma='GSK-3'] theme:Gene_or_gene_productt>e1: trigger-arg-path: interacts >prep_with [lemma='akt'] themetbe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='akt'] Gene_or_gene_producttXe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='akt'] controllertMe1: trigger-arg-path: interacts >prep_with [lemma='akt'] Gene_or_gene_productt!interceding-token ngrams: Akt hast(interceding-token ngrams: has a negativet,interceding-token ngrams: to regulate mTORC1t interceding-token ngrams: , TSC2tie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='akt'] controllert^e2: trigger-arg-path: Positive_regulation >agent [lemma='akt'] controller:Gene_or_gene_productt+interceding-token ngrams: regulate mTORC1 .t$CSSPATH: ROOT  ++ ROOT >advcl >advclt,interceding-token ngrams: negative effect ont)interceding-token ngrams: negative effectt.e1: ents2Label-mention-ngram: with both SHAREDtSe1: trigger-arg-path: interacts:Binding >nsubj [lemma='GSK-3'] Gene_or_gene_producttdinterceding-tokens-full-span: , TSC2 to regulate mTORC1 . Akt has a negative effect on GSK-3 as whentUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='akt'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: interacts with botht)interceding-token ngrams: effect on GSK-3t'interceding-token ngrams: GSK-3 as whent+interceding-token ngrams: a negative effectt&e1: args2Role-mention-ngram: with botht#interceding-token ngrams: . Akt hast"e1: ents2Label-mention-ngram: typetMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='e6'] theme:Familyt+e2: ents2Label-mention-ngram: can associatet-e1: args2Role-mention-ngram: subtypes ( 16,18tKe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with FamilytVe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='e6'] theme:Familyt'e1: args2Role-mention-ngram: ) can bindt&e1: args2Role-mention-ngram: ( 16,18 )tFe1: trigger-arg-path: bind >prep_to [lemma='bak'] Gene_or_gene_productt7e2: trigger-arg-path: associate >prep_with theme:FamilytWe2: trigger-arg-path: associate:Binding >nsubj [lemma='bak'] theme:Gene_or_gene_producttLe2: trigger-arg-path: associate:Binding >prep_with [lemma='e6'] theme:Familyt4e1: trigger-arg-path: bind >nsubj [lemma='e6'] themet+e1: args2Role-mention-ngram: from high-riskt2e2: ents2Label-mention-ngram: SHARED can associatetOe2: trigger-arg-path: associate >nsubj [lemma='bak'] theme:Gene_or_gene_producttQe2: trigger-arg-path: associate:Binding >nsubj [lemma='bak'] Gene_or_gene_productt0e2: trigger-arg-path: associate >prep_with themet!e1: ents2Label-mention-ngram: HPVt8e1: trigger-arg-path: Binding >nsubj [lemma='e6'] Familyt'e1: args2Role-mention-ngram: THEME fromt%interceding-token ngrams: vitro , andt e1: ents2Label-mention-ngram: 11t$interceding-token ngrams: in vitro ,tIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bak'] themet1e2: args2Role-mention-ngram: associate with THEMEtQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bak'] themet*e1: ents2Label-mention-ngram: HPV subtypest%e1: ents2Label-mention-ngram: 16,18 )t/e1: args2Role-mention-ngram: from high-risk HPVtQe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with theme:FamilytUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='e6'] theme:Familyt$e1: args2Role-mention-ngram: 16,18 )t1e1: args2Role-mention-ngram: THEME from high-riskt)e1: args2Role-mention-ngram: and low-riskt;e1: trigger-arg-path: bind >nsubj [lemma='e6'] theme:Familyt$e1: ents2Label-mention-ngram: ( 11 )t'e1: ents2Label-mention-ngram: ( 16,18 )t7e1: trigger-arg-path: Binding >nsubj [lemma='e6'] themetOe1: trigger-arg-path: Binding >prep_to [lemma='bak'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: low-risk type (tMe2: trigger-arg-path: Binding >nsubj [lemma='bak'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: high-riskte1: args2Role-mention-ngram: 11t"e1: ents2Label-mention-ngram: ( 11tGe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='e6'] FamilytBe2: trigger-arg-path: associate:Binding >nsubj [lemma='bak'] themetprep_with [lemma='e6'] Familyt*e1: args2Role-mention-ngram: low-risk typet0e2: args2Role-mention-ngram: THEME can associatetLe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='bak'] themet!e1: args2Role-mention-ngram: 11 )t^e2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='e6'] theme:Familyt'e1: ents2Label-mention-ngram: type ( 11tCe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with Familytae2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='bak'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: HPV subtypes (tOe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='e6'] Familyt0e1: ents2Label-mention-ngram: from high-risk HPVt$e1: args2Role-mention-ngram: ( 16,18t'e1: args2Role-mention-ngram: subtypes (t$interceding-token ngrams: , in vitrotXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bak'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: ( 16,18t=e1: trigger-arg-path: bind:Binding >nsubj [lemma='e6'] FamilytGe2: trigger-arg-path: Binding >nsubj [lemma='bak'] Gene_or_gene_productt9e2: trigger-arg-path: associate:Binding >prep_with Familyt3e1: args2Role-mention-ngram: high-risk HPV subtypest(e1: ents2Label-mention-ngram: subtypes (tTe1: trigger-arg-path: bind:Binding >prep_to [lemma='bak'] theme:Gene_or_gene_productt/e2: args2Role-mention-ngram: can associate witht`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bak'] Gene_or_gene_productt5e1: trigger-arg-path: bind >nsubj [lemma='e6'] Familyt%e1: args2Role-mention-ngram: 11 ) cantXe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='e6'] Familytie2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='bak'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: ) and low-risktXinterceding-tokens-full-span: , in vitro , and can stimulate its degradation , in vivo .t e1: args2Role-mention-ngram: HPVt8e2: trigger-arg-path: associate:Binding >prep_with themet4e1: ents2Label-mention-ngram: high-risk HPV subtypest$e1: ents2Label-mention-ngram: type (t.e1: args2Role-mention-ngram: and low-risk typet#e1: args2Role-mention-ngram: ( 11 )t?e2: trigger-arg-path: associate:Binding >prep_with theme:Familyt)e1: ents2Label-mention-ngram: SHARED fromt'interceding-token ngrams: can stimulatet;e2: trigger-arg-path: Binding >prep_with [lemma='e6'] themet0e2: ents2Label-mention-ngram: can associate withtFe2: trigger-arg-path: associate:Binding >prep_with [lemma='e6'] Familyt"e1: args2Role-mention-ngram: ) cantLe1: trigger-arg-path: bind >prep_to [lemma='bak'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: 11 ) cant(e1: trigger-arg-path: bind >nsubj Familyt#e1: ents2Label-mention-ngram: ) cantBe2: trigger-arg-path: Binding >prep_with [lemma='e6'] theme:Familyt!interceding-token ngrams: and cant8e2: trigger-arg-path: Binding >nsubj [lemma='bak'] themetDe2: trigger-arg-path: associate >prep_with [lemma='e6'] theme:FamilytNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='e6'] themetIe1: trigger-arg-path: Binding >prep_to [lemma='bak'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_to [lemma='bak'] themet.e1: trigger-arg-path: bind >nsubj theme:Familytnsubj [lemma='e6'] themet#e1: ents2Label-mention-ngram: 16,18t+e1: ents2Label-mention-ngram: high-risk HPVt*e1: ents2Label-mention-ngram: and low-risktFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='e6'] themet!e1: args2Role-mention-ngram: typet%e1: args2Role-mention-ngram: subtypest"e1: args2Role-mention-ngram: 16,18t,e1: ents2Label-mention-ngram: from high-riskt:e2: trigger-arg-path: associate >nsubj [lemma='bak'] themet+e1: args2Role-mention-ngram: HPV subtypes (tWe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='e6'] themet)e1: ents2Label-mention-ngram: 16,18 ) andt+interceding-token ngrams: can stimulate itst!e1: args2Role-mention-ngram: ( 11tEe2: trigger-arg-path: associate:Binding >prep_with [lemma='e6'] themet&e1: ents2Label-mention-ngram: subtypest#e1: args2Role-mention-ngram: type (t#interceding-token ngrams: , in vivot)e1: args2Role-mention-ngram: HPV subtypest#interceding-token ngrams: , and cant-e1: ents2Label-mention-ngram: low-risk type (t3interceding-token ngrams: stimulate its degradationt+interceding-token ngrams: and can stimulatetTe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='bak'] themet>e2: trigger-arg-path: associate >prep_with [lemma='e6'] Familyt.e1: ents2Label-mention-ngram: subtypes ( 16,18t6e1: trigger-arg-path: bind:Binding >nsubj theme:Familyt>e1: trigger-arg-path: Binding >nsubj [lemma='e6'] theme:Familyt*interceding-token ngrams: degradation , int%e1: args2Role-mention-ngram: low-riskt3e1: ents2Label-mention-ngram: SHARED from high-risktfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='bak'] theme:Gene_or_gene_productt=e2: trigger-arg-path: associate >prep_with [lemma='e6'] themet?e1: trigger-arg-path: bind:Binding >prep_to [lemma='bak'] themet*e2: args2Role-mention-ngram: can associatet&e1: ents2Label-mention-ngram: low-riskt,e1: ents2Label-mention-ngram: ) and low-riskt+e1: ents2Label-mention-ngram: low-risk typetOe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='e6'] themet"e1: ents2Label-mention-ngram: 11 )t0e1: trigger-arg-path: bind:Binding >nsubj Familyt'interceding-token ngrams: stimulate itst!interceding-token ngrams: vitro ,t1e2: trigger-arg-path: associate >prep_with FamilytNe1: trigger-arg-path: bind:Binding >prep_to [lemma='bak'] Gene_or_gene_productt*e1: args2Role-mention-ngram: high-risk HPVt3e2: ents2Label-mention-ngram: associate with SHAREDtCe1: trigger-arg-path: bind:Binding >nsubj [lemma='e6'] theme:Familyt/e1: ents2Label-mention-ngram: and low-risk typet&e1: args2Role-mention-ngram: high-riskt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='bak'] theme:Gene_or_gene_producttIe2: trigger-arg-path: associate >nsubj [lemma='bak'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='bak'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='bak'] Gene_or_gene_productt(e1: args2Role-mention-ngram: 16,18 ) andt7e1: trigger-arg-path: bind >prep_to [lemma='bak'] themet&e1: args2Role-mention-ngram: type ( 11tPe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='e6'] FamilytIe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with theme:Familyt(e1: ents2Label-mention-ngram: ) can bindtae1: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] themetSe1: trigger-arg-path: interaction >prep_between [lemma='raf1'] Gene_or_gene_producttOinterceding-tokens-full-span: . In this study , we compared the localization oft:CSSPATH: ROOT >dobj >prep_regarding ++ ROOT >dobj >prep_oft%interceding-token ngrams: we comparedtDe1: trigger-arg-path: interaction >prep_between [lemma='raf1'] themet&interceding-token ngrams: compared thet-interceding-token ngrams: the localization oft)interceding-token ngrams: localization oft[e1: trigger-arg-path: interaction:Binding >prep_between [lemma='k-ra'] Gene_or_gene_producttYe1: trigger-arg-path: interaction >prep_between [lemma='raf1'] theme:Gene_or_gene_productt'interceding-token ngrams: , we comparedtae1: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] Gene_or_gene_producttLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='raf1'] themetDe1: trigger-arg-path: interaction >prep_between [lemma='k-ra'] themet3interceding-token ngrams: compared the localizationt$interceding-token ngrams: study , wet)interceding-token ngrams: we compared thet*interceding-token ngrams: the localizationt'interceding-token ngrams: In this studyt&interceding-token ngrams: this study ,tYe1: trigger-arg-path: interaction >prep_between [lemma='k-ra'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interaction >prep_between [lemma='k-ra'] Gene_or_gene_productt*e2: args2Role-mention-ngram: both inhibitstKe1: trigger-arg-path: bound >nsubjpass [lemma='socs3'] Gene_or_gene_producttIe2: trigger-arg-path: Binding >nsubj [lemma='socs3'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='chain'] themetDe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='socs3'] themetZe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='chain'] themet7e2: ents2Label-mention-ngram: signalling and associatest)e2: ents2Label-mention-ngram: SHARED botht+e2: ents2Label-mention-ngram: the activatedtYe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='socs3'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: both inhibitstZe2: trigger-arg-path: associates:Binding >nsubj [lemma='socs3'] theme:Gene_or_gene_productt>e2: trigger-arg-path: Binding >prep_with [lemma='chain'] themet:e2: trigger-arg-path: Binding >nsubj [lemma='socs3'] themet/e2: args2Role-mention-ngram: with the activatedt-e2: ents2Label-mention-ngram: IL-2 signallingtke2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='socs3'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: SHARED both inhibitst=e2: trigger-arg-path: associates >nsubj [lemma='socs3'] themetEe2: trigger-arg-path: associates:Binding >nsubj [lemma='socs3'] themet>e1: trigger-arg-path: Binding >nsubjpass [lemma='socs3'] themetce2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='socs3'] theme:Gene_or_gene_productt0e2: ents2Label-mention-ngram: both inhibits IL-2tge2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='chain'] theme:Gene_or_gene_productt,e2: args2Role-mention-ngram: IL-2 signallingt0e2: ents2Label-mention-ngram: with the activatedt]e2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='socs3'] Gene_or_gene_productt0e2: args2Role-mention-ngram: THEME both inhibitst/e2: args2Role-mention-ngram: both inhibits IL-2tIe2: trigger-arg-path: associates:Binding >prep_with [lemma='chain'] themetee2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='socs3'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: inhibits IL-2 signallingt0e2: args2Role-mention-ngram: the activated THEMEt1e2: ents2Label-mention-ngram: associates with thetQe1: trigger-arg-path: bound >nsubjpass [lemma='socs3'] theme:Gene_or_gene_productt+interceding-tokens-full-span: . Similarly ,t\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='socs3'] Gene_or_gene_producttRe2: trigger-arg-path: associates >nsubj [lemma='socs3'] theme:Gene_or_gene_producttnsubjpass [lemma='socs3'] themetXe2: trigger-arg-path: associates:Binding >prep_with [lemma='chain'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: IL-2 signalling andt^e2: trigger-arg-path: associates:Binding >prep_with [lemma='chain'] theme:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='socs3'] themet0e2: args2Role-mention-ngram: associates with thet@e2: ents2Label-mention-ngram: the activated GENE_OR_GENE_PRODUCTt!e2: args2Role-mention-ngram: IL-2tMe1: trigger-arg-path: Binding >nsubjpass [lemma='socs3'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='socs3'] Gene_or_gene_productt'e2: args2Role-mention-ngram: THEME botht*e2: args2Role-mention-ngram: inhibits IL-2tNe2: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='socs3'] themetMe2: trigger-arg-path: Binding >prep_with [lemma='chain'] Gene_or_gene_producttTe2: trigger-arg-path: associates:Binding >nsubj [lemma='socs3'] Gene_or_gene_productt5e2: args2Role-mention-ngram: inhibits IL-2 signallingtUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='socs3'] themetbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='socs3'] theme:Gene_or_gene_producttOe2: trigger-arg-path: Binding >nsubj [lemma='socs3'] theme:Gene_or_gene_producttAe2: trigger-arg-path: associates >prep_with [lemma='chain'] themetae2: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='chain'] Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='socs3'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: inhibits IL-2t6e2: args2Role-mention-ngram: signalling and associatest0e2: args2Role-mention-ngram: IL-2 signalling andt"e2: ents2Label-mention-ngram: IL-2toe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='chain'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='socs3'] theme:Gene_or_gene_producttSe1: trigger-arg-path: Binding >nsubjpass [lemma='socs3'] theme:Gene_or_gene_producttVe2: trigger-arg-path: associates >prep_with [lemma='chain'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_with [lemma='chain'] theme:Gene_or_gene_producttPe2: trigger-arg-path: associates >prep_with [lemma='chain'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='chain'] Gene_or_gene_productt*e2: args2Role-mention-ngram: the activatedtVe2: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='socs3'] themetLe2: trigger-arg-path: associates >nsubj [lemma='socs3'] Gene_or_gene_productt;CSSPATH: ROOT >advcl >xcomp >ccomp >advcl ++ ROOT >conj_andt0e2: args2Role-mention-ngram: heteroligomers witht3e2: trigger-arg-path: induces >nsubj >nn controllertGe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT forms heteroligomerst[e2: trigger-arg-path: induces >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt$interceding-token ngrams: along withtte2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck1'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ck1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: heteroligomerst+e2: args2Role-mention-ngram: heteroligomerst%interceding-token ngrams: PML nucleart.e2: ents2Label-mention-ngram: MDM2 and inducestze2: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_producttke2: trigger-arg-path: induces >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert-e2: args2Role-mention-ngram: CONTROLLER formst?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_producttre2: trigger-arg-path: Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: MDM2 andtinterceding-tokens-full-span: in response to stress and DNA damage and , along with p53 , localizes to the PML nuclear bodies .t"interceding-token ngrams: bodies .t!interceding-token ngrams: and DNAt!interceding-token ngrams: the PMLt)e2: ents2Label-mention-ngram: and inducest=e2: trigger-arg-path: induces >nsubj >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttQe2: trigger-arg-path: induces >nsubj [lemma='form'] >nn [lemma='mdmx'] controllertSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck1'] Gene_or_gene_productt`e2: trigger-arg-path: induces >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj >nn controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >nn controlledt(interceding-token ngrams: DNA damage andtge2: trigger-arg-path: Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt\e2: trigger-arg-path: induces:Negative_activation >nsubj >nn controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: MDM2 and inducest(e2: args2Role-mention-ngram: and inducest[e2: trigger-arg-path: induces:Negative_activation >dobj >nn controlled:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert!interceding-token ngrams: , alongtae2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >nn Gene_or_gene_producttbe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ck1'] Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ck1'] controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ck1'] controllert%interceding-token ngrams: and , alongt2e2: trigger-arg-path: induces >dobj >nn controlledtle2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: at Thr18t$interceding-token ngrams: damage andt1e2: args2Role-mention-ngram: forms heteroligomerst(interceding-token ngrams: , localizes tot&interceding-token ngrams: damage and ,tse1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ck1'] Gene_or_gene_producttVe2: trigger-arg-path: induces >dobj [lemma='degradation'] >nn [lemma='p53'] controlledt,interceding-token ngrams: PML nuclear bodiest6e2: ents2Label-mention-ngram: heteroligomers with MDM2t2e2: ents2Label-mention-ngram: forms heteroligomerst(interceding-token ngrams: and DNA damagetQe2: trigger-arg-path: induces:Negative_activation >nsubj >nn Gene_or_gene_producttme1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ck1'] controller:Gene_or_gene_producttDe1: trigger-arg-path: phosphorylates >nsubj [lemma='ck1'] controllertje1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ck1'] controller:Gene_or_gene_productt(interceding-token ngrams: stress and DNAt-e1: ents2Label-mention-ngram: SHARED at Thr18t'e2: ents2Label-mention-ngram: with MDM2t*interceding-token ngrams: localizes to thet&e2: args2Role-mention-ngram: with MDM2t)interceding-token ngrams: the PML nucleartYe1: trigger-arg-path: phosphorylates >nsubj [lemma='ck1'] controller:Gene_or_gene_producttee2: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert|e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt5e2: args2Role-mention-ngram: heteroligomers with MDM2t(interceding-token ngrams: nuclear bodiestle2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj >nn controlled:Gene_or_gene_producttPe2: trigger-arg-path: induces:Negative_activation >dobj >nn Gene_or_gene_producttdobj >nn Gene_or_gene_producttje2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledt&interceding-token ngrams: , along withtbe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj >nn Gene_or_gene_producttoe2: trigger-arg-path: induces:Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] Gene_or_gene_productt*e2: args2Role-mention-ngram: with MDM2 andt'interceding-token ngrams: to stress andtie1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ck1'] controllert6e2: args2Role-mention-ngram: forms heteroligomers witht$interceding-token ngrams: to the PMLtHe2: trigger-arg-path: induces >nsubj >nn controller:Gene_or_gene_productt8e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT formste2: trigger-arg-path: induces:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt*interceding-token ngrams: nuclear bodies .tqe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtwe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_producttGe2: trigger-arg-path: induces:Negative_activation >nsubj >nn controllertXe2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >nsubj >nn controllertnsubj [lemma='form'] >nn [lemma='mdmx'] controller:Gene_or_gene_productt]e2: trigger-arg-path: Negative_activation >nsubj [lemma='form'] >nn [lemma='mdmx'] controllert(interceding-token ngrams: along with p53tXe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ck1'] controllertNe1: trigger-arg-path: phosphorylates >nsubj [lemma='ck1'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: heteroligomers witht#e1: ents2Label-mention-ngram: Thr18tFe2: trigger-arg-path: induces:Negative_activation >dobj >nn controlledt{e2: trigger-arg-path: lemmatizedTrigger=induce:Negative_activation >dobj [lemma='degradation'] >nn [lemma='p53'] controlledtinterceding-token ngrams: alongtHe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates SHAREDt%e2: args2Role-mention-ngram: MDM2 andtGe2: trigger-arg-path: induces >dobj >nn controlled:Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='ck1'] controllert3e2: args2Role-mention-ngram: and induces CONTROLLEDt[e2: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj >nn controlled:Gene_or_gene_producttMe2: trigger-arg-path: interacts >prep_with [lemma='erk'] Gene_or_gene_productt-e1: args2Role-mention-ngram: which negativelytUe1: trigger-arg-path: lemmatizedTrigger=negatively regulate prep_with [lemma='erk'] theme:Gene_or_gene_producttCe2: trigger-arg-path: interacts:Binding >nsubj [lemma='mkp3'] themetWe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='erk'] themet?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt-e1: args2Role-mention-ngram: CONTROLLER , thet?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlledt0e1: ents2Label-mention-ngram: phosphatase MKP3 ,t,e1: args2Role-mention-ngram: the phosphataset9e2: trigger-arg-path: Binding >nsubj [lemma='mkp3'] themet;e2: trigger-arg-path: interacts >nsubj [lemma='mkp3'] themet_e1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj >nn Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj [lemma='mkp3'] theme:Gene_or_gene_productt#e1: args2Role-mention-ngram: MKP3 ,tNe2: trigger-arg-path: Binding >nsubj [lemma='mkp3'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttJe2: trigger-arg-path: interacts >nsubj [lemma='mkp3'] Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt.e1: args2Role-mention-ngram: , the phosphataset[e1: trigger-arg-path: negatively regulates:Negative_activation dobj >nn controlledt.e1: ents2Label-mention-ngram: phosphatase MKP3t[e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] Gene_or_gene_producttprep_with [lemma='erk'] themetHe2: trigger-arg-path: Binding >nsubj [lemma='mkp3'] Gene_or_gene_productt?e1: trigger-arg-path: Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt7e1: args2Role-mention-ngram: which negatively regulatest?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj >nn controlled:Gene_or_gene_producttpe1: trigger-arg-path: negatively regulates:Negative_activation dobj >nn controlled:Gene_or_gene_productt!e1: args2Role-mention-ngram: MKP3t-e1: ents2Label-mention-ngram: the phosphatasetLe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] themet)e1: args2Role-mention-ngram: MKP3 , whichtae2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='mkp3'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: regulates CONTROLLEDtRe2: trigger-arg-path: interacts:Binding >nsubj [lemma='mkp3'] Gene_or_gene_producttFe1: trigger-arg-path: Negative_activation dobj >nn controlledtne1: trigger-arg-path: Negative_activation nsubj [lemma='mkp3'] theme:Gene_or_gene_producttUe2: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] Gene_or_gene_producttee1: trigger-arg-path: negatively regulates dobj >nn controlledtbe1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj >nn Gene_or_gene_productt.e1: ents2Label-mention-ngram: regulates SHAREDt-e1: args2Role-mention-ngram: phosphatase MKP3tde1: trigger-arg-path: Negative_activation e2: trigger-arg-path: interacts >prep_with [lemma='erk'] themetXe1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj >nn controlledtDe1: trigger-arg-path: negatively regulates dobj >nn Gene_or_gene_productt*interceding-tokens-full-span: activation .t?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate prep_with [lemma='erk'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_productt*CSSPATH: ROOT >rcmod >dobj >rcmod ++ ROOT t?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj >nn controlled:Gene_or_gene_producttFe2: trigger-arg-path: interacts:Binding >prep_with [lemma='erk'] themet9e1: ents2Label-mention-ngram: negatively regulates SHAREDt/e1: ents2Label-mention-ngram: , the phosphatasetXe1: trigger-arg-path: Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: negatively regulates dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] Gene_or_gene_productt/e1: args2Role-mention-ngram: , which negativelyt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj [lemma='mkp3'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_with [lemma='erk'] Gene_or_gene_productt}e1: trigger-arg-path: negatively regulates dobj [lemma='activation'] >nn [lemma='erk'] controlledtbe1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] Gene_or_gene_producttme1: trigger-arg-path: negatively regulates:Negative_activation dobj >nn controlled:Gene_or_gene_producttprep_with [lemma='erk'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] themetye1: trigger-arg-path: negatively regulates:Negative_activation nsubj [lemma='mkp3'] Gene_or_gene_producttQe1: trigger-arg-path: negatively regulates dobj >nn Gene_or_gene_producttMe1: trigger-arg-path: Negative_activation prep_with [lemma='erk'] Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_activation nsubj [lemma='mkp3'] themet1e1: args2Role-mention-ngram: the phosphatase MKP3t~e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='activation'] >nn [lemma='erk'] controlled:Gene_or_gene_productt/e1: args2Role-mention-ngram: phosphatase MKP3 ,tGe1: trigger-arg-path: negatively regulates dobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj [lemma='activation'] >nn [lemma='erk'] controlledtie1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj >nn Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='erk'] theme:Gene_or_gene_productt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , thet>e1: trigger-arg-path: Binding >nsubj [lemma='egfrviius'] themet)interceding-token ngrams: tumorigenesis .t/interceding-token ngrams: to activate signalingt.interceding-token ngrams: migration , invasiont(interceding-token ngrams: , invasion andt'interceding-token ngrams: and chemokinet*interceding-token ngrams: in comparison tot_e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfr1'] themet7interceding-token ngrams: interactions between EGFRvIIIt%interceding-token ngrams: chemokine (t[e2: trigger-arg-path: interactions >prep_between [lemma='egfr1'] theme:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='egfrviius'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='her2'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='egfrviius'] Gene_or_gene_productt5interceding-token ngrams: activate signaling pathwayst#interceding-token ngrams: 4 ( CXCR4tne2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfr1'] Gene_or_gene_producttGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='her2'] themet"interceding-token ngrams: and HER2tTe1: trigger-arg-path: interacts >prep_with [lemma='her2'] theme:Gene_or_gene_productt.interceding-token ngrams: between EGFRvIII andt#interceding-token ngrams: CXCR4 mayt!interceding-token ngrams: CXCR4 )t$interceding-token ngrams: CXCR4 ) totle2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfr1'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='her2'] themet&interceding-token ngrams: receptor 4 (t!interceding-token ngrams: motif )t'interceding-token ngrams: in comparisontRe1: trigger-arg-path: Binding >prep_with [lemma='her2'] theme:Gene_or_gene_productt@e1: trigger-arg-path: interacts >nsubj [lemma='egfrviius'] themet(interceding-token ngrams: in migration ,t+interceding-token ngrams: chemokine ( C-X-Ct+interceding-token ngrams: and tumorigenesist&interceding-token ngrams: prolonged int&interceding-token ngrams: ) receptor 4tinterceding-token ngrams: CXCR4t$interceding-token ngrams: receptor 4tQe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='egfrviius'] themet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='her2'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='her2'] themet0interceding-token ngrams: important in migrationtOe1: trigger-arg-path: interacts >nsubj [lemma='egfrviius'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >nsubj [lemma='egfrviius'] theme:Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='egfr1'] theme:Gene_or_gene_producttVe2: trigger-arg-path: Binding >prep_between [lemma='egfr1'] theme:Gene_or_gene_productt'interceding-token ngrams: comparison totWe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfr1'] themet4interceding-token ngrams: invasion and tumorigenesistinterceding-token ngrams: C-X-CtVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='her2'] Gene_or_gene_productt#interceding-token ngrams: chemokinet+interceding-token ngrams: EGFRvIII and HER2t6interceding-token ngrams: signaling pathways importanttLe1: trigger-arg-path: Binding >prep_with [lemma='her2'] Gene_or_gene_producttHe1: trigger-arg-path: interacts:Binding >nsubj [lemma='egfrviius'] themet4interceding-token ngrams: These interactions betweent&interceding-token ngrams: invasion andt'interceding-token ngrams: ( C-X-C motift%interceding-token ngrams: C-X-C motift-interceding-token ngrams: and tumorigenesis .t&interceding-token ngrams: important intme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='her2'] theme:Gene_or_gene_productt)interceding-token ngrams: be prolonged int(interceding-token ngrams: HER2 and CXCR4t#interceding-token ngrams: and CXCR4t&interceding-token ngrams: EGFRvIII andtce2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfr1'] theme:Gene_or_gene_producttinterceding-token ngrams: 4 (t&interceding-token ngrams: CXCR4 may betfe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='egfrviius'] theme:Gene_or_gene_productt&interceding-token ngrams: and HER2 andt$interceding-token ngrams: comparisont)interceding-token ngrams: and chemokine (tAe2: trigger-arg-path: Binding >prep_between [lemma='egfr1'] themet&interceding-token ngrams: be prolongedtCSSPATH: ROOT  ++ ROOT >prep_tot/interceding-token ngrams: tumorigenesis . ThesetPe2: trigger-arg-path: Binding >prep_between [lemma='egfr1'] Gene_or_gene_producttUe2: trigger-arg-path: interactions >prep_between [lemma='egfr1'] Gene_or_gene_producttNe1: trigger-arg-path: interacts >prep_with [lemma='her2'] Gene_or_gene_productt,interceding-token ngrams: These interactionst*interceding-token ngrams: motif ) receptort?interceding-tokens-full-span: and chemokine ( C-X-C motif ) receptor 4 ( CXCR4 ) to activate signaling pathways important in migration , invasion and tumorigenesis . These interactions between EGFRvIII and HER2 and CXCR4 may be prolonged in comparison tothe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='egfrviius'] Gene_or_gene_productt$interceding-token ngrams: , invasiontfe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='egfr1'] Gene_or_gene_productt%interceding-token ngrams: migration ,tNe2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfr1'] themet*interceding-token ngrams: between EGFRvIIIt&interceding-token ngrams: in migrationt'interceding-token ngrams: and CXCR4 mayt#interceding-token ngrams: ( CXCR4 )t$interceding-token ngrams: ) receptort1interceding-token ngrams: prolonged in comparisont\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='her2'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='egfrviius'] Gene_or_gene_producttUe1: trigger-arg-path: interacts >nsubj [lemma='egfrviius'] theme:Gene_or_gene_producttFe2: trigger-arg-path: interactions >prep_between [lemma='egfr1'] themet'interceding-token ngrams: C-X-C motif )t,interceding-token ngrams: signaling pathwaystYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='egfrviius'] themet'interceding-token ngrams: tumorigenesist'interceding-token ngrams: ) to activatet!interceding-token ngrams: ( CXCR4t interceding-token ngrams: may bet?e1: trigger-arg-path: interacts >prep_with [lemma='her2'] themetWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='egfrviius'] Gene_or_gene_productt]e2: trigger-arg-path: interactions:Binding >prep_between [lemma='egfr1'] Gene_or_gene_productt*interceding-token ngrams: may be prolongedt,interceding-token ngrams: pathways importanttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='her2'] Gene_or_gene_productt]e1: trigger-arg-path: interacts:Binding >nsubj [lemma='egfrviius'] theme:Gene_or_gene_producttGe2: ents2Label-mention-ngram: interactions between GENE_OR_GENE_PRODUCTt/interceding-token ngrams: pathways important int!interceding-token ngrams: ( C-X-Ct.interceding-token ngrams: . These interactionst,interceding-token ngrams: activate signalingtee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='her2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn theme:FamilytEe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn Familytre2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetMe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn Familytze2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetDe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn themethe2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familyt4e1: trigger-arg-path: bound >ccomp >nsubj >nn FamilytBe2: trigger-arg-path: bound:Binding >ccomp >nsubj >nn theme:Familyt5e2: trigger-arg-path: Binding >ccomp >nsubj >nn themetre1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetccomp >nsubj >nn FamilytMe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn Familytje2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familyt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familytye1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:FamilytKe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn theme:Familytie1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetpe2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familytde2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familythe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:FamilytBe1: trigger-arg-path: bound:Binding >ccomp >nsubj >nn theme:FamilytKe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn theme:FamilytDe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn themetje1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familytse2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] FamilytEe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj >nn Familyt:e2: trigger-arg-path: bound >ccomp >nsubj >nn theme:Familyt3e1: trigger-arg-path: bound >ccomp >nsubj >nn themet;e2: trigger-arg-path: bound:Binding >ccomp >nsubj >nn themetde1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familytce1: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetie2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themet?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familytccomp >nsubj >nn theme:Familyt4e2: trigger-arg-path: bound >ccomp >nsubj >nn Familytce2: trigger-arg-path: Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn theme:Familyt6e1: trigger-arg-path: Binding >ccomp >nsubj >nn Familyt;e1: trigger-arg-path: bound:Binding >ccomp >nsubj >nn themet3e2: trigger-arg-path: bound >ccomp >nsubj >nn themetae1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themet{e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familytbe1: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] FamilytLe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn themetze1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetae2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] themetpe1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:Familytccomp >nsubj >nn Familytbe2: trigger-arg-path: bound >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familyt{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familyt6e2: trigger-arg-path: Binding >ccomp >nsubj >nn Familyt5e1: trigger-arg-path: Binding >ccomp >nsubj >nn themetye2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] theme:FamilytLe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj >nn themetse1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familytje2: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familytccomp >nsubj >nn theme:Familytje1: trigger-arg-path: bound:Binding >ccomp [lemma='bind'] >nsubj [lemma='protein'] >nn [lemma='ra'] Familyt:e1: trigger-arg-path: bound >ccomp >nsubj >nn theme:Familytre1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controllert1interceding-token ngrams: the recombinant RASSF1Atne1: trigger-arg-path: reduces:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlledtMe1: trigger-arg-path: reduces >nsubj >prep_of controller:Gene_or_gene_producttTe2: trigger-arg-path: Binding >prep_between [lemma='ksr'] theme:Gene_or_gene_producttje1: trigger-arg-path: Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controllert*interceding-token ngrams: activation . Thet.interceding-token ngrams: activate recombinantt&interceding-token ngrams: activation ;tNe2: trigger-arg-path: Binding >prep_between [lemma='ksr'] Gene_or_gene_productt/interceding-token ngrams: scaffold for Aurora-At1interceding-token ngrams: for Aurora-A activationtBe1: trigger-arg-path: reduces >nsubj >prep_of Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] Gene_or_gene_productt-interceding-token ngrams: recombinant RASSF1At(interceding-token ngrams: a scaffold fort%interceding-token ngrams: Aurora-A int.interceding-token ngrams: RASSF1A may functiontbe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] themet*interceding-token ngrams: that RASSF1A mayte1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlledt.interceding-token ngrams: recombinant Aurora-At?e1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controller:Gene_or_gene_producttfe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlledtRe2: trigger-arg-path: interaction >prep_between [lemma='ksr'] Gene_or_gene_productt:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reduceste1: trigger-arg-path: Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controller:Gene_or_gene_productt)interceding-token ngrams: the recombinantt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controllert1interceding-token ngrams: recombinant Aurora-A intDe2: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] themetVe1: trigger-arg-path: reduces:Negative_activation >nsubj >prep_of Gene_or_gene_producttYe2: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT reduces SHAREDtwe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttXe2: trigger-arg-path: interaction >prep_between [lemma='ksr'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlled:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controllert^e1: trigger-arg-path: reduces >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controllert,interceding-token ngrams: possibility of thetCe2: trigger-arg-path: interaction >prep_between [lemma='ksr'] themet/e1: args2Role-mention-ngram: reduces CONTROLLEDtoe1: trigger-arg-path: reduces >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlled:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj >prep_of Gene_or_gene_productt?interceding-tokens-full-span: activation ; however , the recombinant RASSF1A can not activate recombinant Aurora-A in vitro suggesting that RASSF1A may function as a scaffold for Aurora-A activation . The possibility of thet!interceding-token ngrams: can nott?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controller:Gene_or_gene_producttLe1: trigger-arg-path: reduces:Negative_activation >nsubj >prep_of controllert"interceding-token ngrams: scaffoldt+interceding-token ngrams: Aurora-A in vitrot]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ksr'] themet?e1: trigger-arg-path: reduces:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlled:Gene_or_gene_producttse1: trigger-arg-path: reduces >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='aurora-a'] Gene_or_gene_producttWe2: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] Gene_or_gene_productt8e1: trigger-arg-path: reduces >nsubj >prep_of controllert|e1: trigger-arg-path: reduces:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj >prep_of controllert*interceding-token ngrams: can not activatet&interceding-token ngrams: scaffold fort%interceding-token ngrams: RASSF1A cant`e2: trigger-arg-path: interaction:Binding >prep_between [lemma='ksr'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ksr'] themet/e1: args2Role-mention-ngram: CONTROLLER reducestSe2: trigger-arg-path: Binding >prep_between [lemma='aurora-a'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ksr'] Gene_or_gene_productt-interceding-token ngrams: in vitro suggestingthe1: trigger-arg-path: reduces >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_between [lemma='ksr'] themetoe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] theme:Gene_or_gene_productt'interceding-token ngrams: as a scaffoldt%interceding-token ngrams: RASSF1A maytte1: trigger-arg-path: Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ksr'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj >prep_of controller:Gene_or_gene_productt,interceding-token ngrams: The possibility oft.interceding-token ngrams: activation ; howevert+interceding-token ngrams: . The possibilityt?e1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] controller:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=reduce >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='aurora-a'] Gene_or_gene_productt/interceding-token ngrams: vitro suggesting thatt/interceding-token ngrams: Aurora-A activation .tHe2: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] themetxe1: trigger-arg-path: reduces:Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] Gene_or_gene_productt"interceding-token ngrams: Aurora-At?e1: trigger-arg-path: lemmatizedTrigger=reduce:Negative_activation >nsubj [lemma='Knockdown'] >prep_of [lemma='rassf1a'] Gene_or_gene_producttee2: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] theme:Gene_or_gene_producttpe1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] Gene_or_gene_productt1interceding-token ngrams: recombinant RASSF1A cantde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='ksr'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: reduces SHAREDt(interceding-token ngrams: possibility oft]e2: trigger-arg-path: interaction >prep_between [lemma='aurora-a'] theme:Gene_or_gene_productt-interceding-token ngrams: Aurora-A activationt2interceding-token ngrams: not activate recombinantt1interceding-token ngrams: suggesting that RASSF1At_e2: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] Gene_or_gene_productt{e1: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlled:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='ksr'] theme:Gene_or_gene_productt)interceding-token ngrams: RASSF1A can nottae1: trigger-arg-path: reduces:Negative_activation >nsubj >prep_of controller:Gene_or_gene_producttde1: trigger-arg-path: reduces >dobj [lemma='activation'] >nn [lemma='aurora-a'] Gene_or_gene_productt&interceding-token ngrams: for Aurora-At&interceding-token ngrams: that RASSF1AtZe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] themetPe2: trigger-arg-path: interaction:Binding >prep_between [lemma='aurora-a'] themetZe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ksr'] Gene_or_gene_productt+interceding-token ngrams: , the recombinantt)interceding-token ngrams: The possibilitytie2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='aurora-a'] Gene_or_gene_productt7interceding-token ngrams: activate recombinant Aurora-At?e1: trigger-arg-path: lemmatizedTrigger=reduce >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlled:Gene_or_gene_productt$interceding-token ngrams: a scaffoldtKe2: trigger-arg-path: interaction:Binding >prep_between [lemma='ksr'] themet*interceding-token ngrams: vitro suggestingtZe1: trigger-arg-path: reduces >dobj [lemma='activation'] >nn [lemma='aurora-a'] controlledt:e1: args2Role-mention-ngram: CONTROLLER reduces CONTROLLEDt)interceding-token ngrams: results in NRF2tinterceding-token ngrams: X )t\e2: trigger-arg-path: inhibits:Negative_activation >dobj >nn controlled:Gene_or_gene_productt$interceding-token ngrams: proteasomet.e2: ents2Label-mention-ngram: , interacts withtPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nrf2'] themetfe2: trigger-arg-path: Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_producttKe1: trigger-arg-path: interacts >nsubj [lemma='keap1'] Gene_or_gene_productt1e2: args2Role-mention-ngram: interacts with KEAP1t(e2: args2Role-mention-ngram: , interactst[e2: trigger-arg-path: inhibits >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlledtQe2: trigger-arg-path: inhibits:Negative_activation >dobj >nn Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='keap1'] themet)interceding-token ngrams: that results intGe2: trigger-arg-path: inhibits:Negative_activation >dobj >nn controlledtinterceding-token ngrams: CUL3t&interceding-token ngrams: that resultst#interceding-token ngrams: as a bluet1interceding-token ngrams: NRF2 ubiquitylation andt,interceding-token ngrams: ubiquitylation andtee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nrf2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt,e2: ents2Label-mention-ngram: with KEAP1 andtee2: trigger-arg-path: inhibits >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='gene'] >nn [lemma='p53'] controllert"interceding-token ngrams: depictedtYe1: trigger-arg-path: interacts:Binding >nsubj [lemma='keap1'] theme:Gene_or_gene_producttIe2: trigger-arg-path: inhibits >nsubj >nn controller:Gene_or_gene_productt+interceding-token ngrams: by the proteasomet(e2: args2Role-mention-ngram: target genet'interceding-token ngrams: depicted as atQe2: trigger-arg-path: inhibits >nsubj [lemma='gene'] >nn [lemma='p53'] controllert/interceding-token ngrams: proteasome ( depictedtQe1: trigger-arg-path: interacts >nsubj [lemma='keap1'] theme:Gene_or_gene_productt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT targett-e2: args2Role-mention-ngram: , interacts withtXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nrf2'] themet?interceding-tokens-full-span: and forms a complex with the E3 ligase CUL3 that results in NRF2 ubiquitylation and degradation by the proteasome ( depicted as a blue X ) . ThetDe1: trigger-arg-path: interacts:Binding >nsubj [lemma='keap1'] themet*e2: args2Role-mention-ngram: target gene ,t\e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='keap1'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='nrf2'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='nrf2'] Gene_or_gene_productt-interceding-token ngrams: NRF2 ubiquitylationtinterceding-token ngrams: X ) .t{e2: trigger-arg-path: Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: KEAP1 andt'interceding-token ngrams: ( depicted ast#interceding-token ngrams: and formst+e2: args2Role-mention-ngram: with KEAP1 andt%e2: ents2Label-mention-ngram: , p21 ,tTe1: trigger-arg-path: interacts >prep_with [lemma='nrf2'] theme:Gene_or_gene_productt+interceding-token ngrams: CUL3 that resultst2e2: ents2Label-mention-ngram: interacts with KEAP1t!interceding-token ngrams: ) . Thetpe2: trigger-arg-path: inhibits >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlled:Gene_or_gene_producttVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='nrf2'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: gene , p21tfe2: trigger-arg-path: inhibits >nsubj [lemma='gene'] >nn [lemma='p53'] controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='keap1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] Gene_or_gene_productt.e2: args2Role-mention-ngram: CONTROLLER targettqe2: trigger-arg-path: Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controller:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubj [lemma='keap1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='keap1'] theme:Gene_or_gene_producttSe1: trigger-arg-path: interacts:Binding >nsubj [lemma='keap1'] Gene_or_gene_producttHe2: trigger-arg-path: inhibits:Negative_activation >nsubj >nn controllertRe2: trigger-arg-path: inhibits:Negative_activation >nsubj >nn Gene_or_gene_productt'e2: args2Role-mention-ngram: gene , p21t interceding-token ngrams: a bluet(interceding-token ngrams: the proteasomet%interceding-token ngrams: ligase CUL3tRe1: trigger-arg-path: Binding >prep_with [lemma='nrf2'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: target gene ,t>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT target genet0interceding-token ngrams: in NRF2 ubiquitylationt&e2: args2Role-mention-ngram: KEAP1 andtoe2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlledt$e2: args2Role-mention-ngram: , p21 ,tNe1: trigger-arg-path: interacts >prep_with [lemma='nrf2'] Gene_or_gene_productt,interceding-token ngrams: degradation by thet(interceding-token ngrams: E3 ligase CUL3t'e2: args2Role-mention-ngram: with KEAP1t%interceding-token ngrams: depicted astMe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='keap1'] themetnsubj [lemma='keap1'] themet-e2: ents2Label-mention-ngram: p21 , interactst!interceding-token ngrams: in NRF2t"e2: args2Role-mention-ngram: , p21t]e2: trigger-arg-path: inhibits:Negative_activation >nsubj >nn controller:Gene_or_gene_producttoe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt*interceding-token ngrams: ligase CUL3 thatt(e2: ents2Label-mention-ngram: with KEAP1t>e2: trigger-arg-path: inhibits >nsubj >nn Gene_or_gene_productt#e2: ents2Label-mention-ngram: , p21tHe2: trigger-arg-path: inhibits >dobj >nn controlled:Gene_or_gene_producttee2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controllert?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controller:Gene_or_gene_producttye2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] Gene_or_gene_productt,e2: args2Role-mention-ngram: p21 , interactst&interceding-token ngrams: proteasome (t?e1: trigger-arg-path: interacts >prep_with [lemma='nrf2'] themet?e2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlled:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nrf2'] theme:Gene_or_gene_productt:e1: trigger-arg-path: Binding >nsubj [lemma='keap1'] themet$e2: ents2Label-mention-ngram: gene ,tge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='nrf2'] Gene_or_gene_productt8interceding-token ngrams: ubiquitylation and degradationtIe1: trigger-arg-path: Binding >nsubj [lemma='keap1'] Gene_or_gene_producttpe2: trigger-arg-path: Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] Gene_or_gene_productt$interceding-token ngrams: ( depictedt,interceding-token ngrams: and degradation bytinterceding-token ngrams: Xt)e2: ents2Label-mention-ngram: , interactst*interceding-token ngrams: the proteasome (t*interceding-token ngrams: complex with thetze2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controller:Gene_or_gene_producttinterceding-token ngrams: bluet?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlledt%interceding-token ngrams: and forms atve2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controllertle2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: KEAP1 and inhibitst(interceding-token ngrams: degradation bytfe2: trigger-arg-path: Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlledt%interceding-token ngrams: with the E3t(interceding-token ngrams: ubiquitylationt\e2: trigger-arg-path: Negative_activation >nsubj [lemma='gene'] >nn [lemma='p53'] controllert"e2: args2Role-mention-ngram: KEAP1tbe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='keap1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: target genet interceding-token ngrams: blue Xt\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='nrf2'] theme:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='nrf2'] themet3e2: args2Role-mention-ngram: CONTROLLER target genet#e2: args2Role-mention-ngram: gene ,t/e2: args2Role-mention-ngram: KEAP1 and inhibitst=e2: trigger-arg-path: inhibits >dobj >nn Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitylation'] >nn [lemma='nrf2'] controlledtGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='nrf2'] themet"interceding-token ngrams: a blue Xt"interceding-token ngrams: blue X )tinterceding-token ngrams: NRF2t#interceding-token ngrams: CUL3 thatt#e2: ents2Label-mention-ngram: KEAP1t[e2: trigger-arg-path: inhibits >nsubj [lemma='gene'] >nn [lemma='p53'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='gene'] >nn [lemma='p53'] controller:Gene_or_gene_productt3e2: trigger-arg-path: inhibits >dobj >nn controlledtee2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='cdc25'] theme:Gene_or_gene_productt"interceding-token ngrams: the steptinterceding-token ngrams: of Kte2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] theme:Gene_or_gene_productt interceding-token ngrams: reactstCe2: trigger-arg-path: complex >amod >dep theme:Gene_or_gene_producttEe2: trigger-arg-path: complex:Binding >amod >dep Gene_or_gene_productt=e2: trigger-arg-path: complex >amod >dep Gene_or_gene_productt_e2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='cdc25'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod >dep theme:Gene_or_gene_productt-interceding-token ngrams: radicalized ternaryt)interceding-token ngrams: the radicalizedt@e2: trigger-arg-path: lemmatizedTrigger=complex >amod >dep themet*interceding-token ngrams: exists , throught'interceding-token ngrams: , through thetOe2: trigger-arg-path: lemmatizedTrigger=complex >amod >dep Gene_or_gene_producttPe2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] themetinterceding-token ngrams: I ,t`e2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='GDP'] themet!interceding-token ngrams: I , thetPe2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='cdc25'] themet.e2: trigger-arg-path: complex >amod >dep themet interceding-token ngrams: existst*interceding-token ngrams: through the steptBCSSPATH: ROOT >ccomp >vmod >ccomp ++ ROOT >xcomp >dobj >vmod >dobjt!interceding-token ngrams: step oft'interceding-token ngrams: an oxidant --tee2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod >dep themet=e2: trigger-arg-path: Binding >amod >dep Gene_or_gene_productt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound wtt'e1: ents2Label-mention-ngram: wt FAMILYt$interceding-token ngrams: oxidant totWe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod >dep Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] themet)interceding-token ngrams: inhibitor -- ant"interceding-token ngrams: When thetUe2: trigger-arg-path: lemmatizedTrigger=complex >amod >dep theme:Gene_or_gene_productt#interceding-token ngrams: -- existstinterceding-token ngrams: -- antNe2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='GDP'] themetXe2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] themet#interceding-token ngrams: , throught.interceding-token ngrams: Cdc25 complex reactst,interceding-token ngrams: oxidant to producetme2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] theme:Gene_or_gene_productt"interceding-token ngrams: exists ,t$interceding-token ngrams: oxidant --t%interceding-token ngrams: the step oft*interceding-token ngrams: with the oxidanttinterceding-token ngrams: --t,interceding-token ngrams: When the inhibitortNe2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='GDP'] themet%interceding-token ngrams: -- exists ,t%interceding-token ngrams: reacts withtce2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='GDP'] theme:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='cdc25'] theme:Gene_or_gene_productt0interceding-token ngrams: radicalized ternary wtt interceding-token ngrams: of K It6e2: trigger-arg-path: complex:Binding >amod >dep themetKe2: trigger-arg-path: complex:Binding >amod >dep theme:Gene_or_gene_producttee2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] theme:Gene_or_gene_productt$interceding-token ngrams: an oxidantt+interceding-token ngrams: oxidant -- existst%interceding-token ngrams: radicalizedt'interceding-token ngrams: , the ternarytinterceding-token ngrams: K I ,t-e1: ents2Label-mention-ngram: bound wt FAMILYtje2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] themet(interceding-token ngrams: the oxidant totVe2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] themetce2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='GDP'] theme:Gene_or_gene_productt-interceding-token ngrams: complex reacts withtke2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] theme:Gene_or_gene_productt$interceding-token ngrams: . When thetbe2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='cdc25'] themet}e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] theme:Gene_or_gene_productt&interceding-token ngrams: inhibitor --toe2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='GDP'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] Gene_or_gene_productt#interceding-token ngrams: step of Kt.e2: trigger-arg-path: Binding >amod >dep themet)interceding-token ngrams: reacts with thet*interceding-token ngrams: the inhibitor --tue2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='GDP'] theme:Gene_or_gene_productt]e2: trigger-arg-path: complex >amod [lemma='ternary'] >dep [lemma='GDP'] Gene_or_gene_productt1interceding-token ngrams: produce the radicalizedt?interceding-tokens-full-span: . When the inhibitor -- an oxidant -- exists , through the step of K I , the ternary wt Ras , GDP and Cdc25 complex reacts with the oxidant to produce the radicalized ternary wt Ras ,t_e2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=complex >amod [lemma='ternary'] >dep [lemma='cdc25'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >amod [lemma='ternary'] >dep [lemma='GDP'] Gene_or_gene_productt'interceding-token ngrams: -- an oxidanttge2: trigger-arg-path: complex:Binding >amod [lemma='ternary'] >dep [lemma='cdc25'] Gene_or_gene_productt'interceding-token ngrams: the inhibitort(interceding-token ngrams: complex reactst]e2: trigger-arg-path: Binding >amod [lemma='ternary'] >dep [lemma='GDP'] Gene_or_gene_productt1interceding-token ngrams: the radicalized ternarytCe2: trigger-arg-path: Binding >amod >dep theme:Gene_or_gene_productt4e2: ents2Label-mention-ngram: and FAMILY interactiont)e2: ents2Label-mention-ngram: nuclear p53t#e1: ents2Label-mention-ngram: Ser15t"interceding-token ngrams: Thr577 .t(e2: ents2Label-mention-ngram: and FAMILYt'e2: ents2Label-mention-ngram: cytoplasmtNe1: trigger-arg-path: lemmatizedTrigger=induce nn Gene_or_gene_productt#interceding-token ngrams: at Thr577t1e1: ents2Label-mention-ngram: stimulation inducest?e1: trigger-arg-path: induces:Positive_regulation nn [lemma='uvb'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='uvb'] controller:Gene_or_gene_producttFe1: ents2Label-mention-ngram: stimulation induces GENE_OR_GENE_PRODUCTt8e2: ents2Label-mention-ngram: accumulation and increasestme1: trigger-arg-path: Positive_regulation nn [lemma='uvb'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: induces nucleart;e1: args2Role-mention-ngram: CONTROLLER stimulation inducestBinterceding-tokens-full-span: and RSK2 phosphorylation at Thr577 .tCSSPATH: ROOT >rcmod ++ ROOT the1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='uvb'] controllert2e2: ents2Label-mention-ngram: in cytoplasm inducest+e2: ents2Label-mention-ngram: and increasest@e2: ents2Label-mention-ngram: and increases GENE_OR_GENE_PRODUCTt}e1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='uvb'] controller:Gene_or_gene_producttHe1: trigger-arg-path: induces nn controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: FAMILY interactiontle1: trigger-arg-path: induces nn [lemma='uvb'] controller:Gene_or_gene_productt/e2: ents2Label-mention-ngram: cytoplasm inducest=e1: trigger-arg-path: induces nn Gene_or_gene_productt\e1: trigger-arg-path: induces:Positive_regulation nn controller:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='uvb'] controllert0e1: args2Role-mention-ngram: stimulation inducest1e2: ents2Label-mention-ngram: induces nuclear p53t.interceding-token ngrams: RSK2 phosphorylationt6e2: ents2Label-mention-ngram: nuclear p53 accumulationt2interceding-token ngrams: and RSK2 phosphorylationtme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn controller:Gene_or_gene_productt%interceding-token ngrams: at Thr577 .t interceding-token ngrams: Thr577t6e1: ents2Label-mention-ngram: phosphorylation at Ser15tEe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylation intJe1: ents2Label-mention-ngram: induces GENE_OR_GENE_PRODUCT phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn [lemma='uvb'] Gene_or_gene_productt1interceding-token ngrams: RSK2 phosphorylation att.e2: ents2Label-mention-ngram: p53 accumulationtbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn Gene_or_gene_productt3interceding-token ngrams: phosphorylation at Thr577tke1: trigger-arg-path: induces:Positive_regulation nn [lemma='uvb'] controllert&e1: ents2Label-mention-ngram: at Ser15t:e2: ents2Label-mention-ngram: phosphorylation in cytoplasmtPe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated GENE_OR_GENE_PRODUCTt*e2: ents2Label-mention-ngram: in cytoplasmtGe1: trigger-arg-path: induces:Positive_regulation nn controllert2e2: ents2Label-mention-ngram: p53 accumulation andtFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulation inducestYe1: trigger-arg-path: lemmatizedTrigger=induce nn controller:Gene_or_gene_productt"interceding-token ngrams: and RSK2tDe1: trigger-arg-path: lemmatizedTrigger=induce nn controllertxe1: trigger-arg-path: Positive_regulation nn [lemma='uvb'] controller:Gene_or_gene_producttEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylation attXe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nn controllertce1: trigger-arg-path: Positive_regulation nn [lemma='uvb'] controllert;e1: args2Role-mention-ngram: stimulation induces CONTROLLEDtue1: trigger-arg-path: induces:Positive_regulation nn [lemma='uvb'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and FAMILYt7e2: ents2Label-mention-ngram: cytoplasm induces nucleartre1: trigger-arg-path: lemmatizedTrigger=induce nn [lemma='uvb'] Gene_or_gene_producttae1: trigger-arg-path: induces nn [lemma='uvb'] Gene_or_gene_producttWe1: trigger-arg-path: induces nn [lemma='uvb'] controllert3e1: trigger-arg-path: induces nn controllertQe1: trigger-arg-path: induces:Positive_regulation nn Gene_or_gene_producttDe1: trigger-arg-path: bind >dobj >prep_of theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: bind the N-terminust>e1: trigger-arg-path: bind >dobj >prep_of Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_producttNe2: trigger-arg-path: mediated:Positive_activation >nsubj >prep_for controllert*e1: ents2Label-mention-ngram: not bind thet,CSSPATH: ROOT >prep_in >vmod >ccomp ++ ROOT tZe1: trigger-arg-path: bind:Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] themetZe2: trigger-arg-path: Positive_activation >nsubj >prep_for controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn controlledt)e1: ents2Label-mention-ngram: SHARED doestinterceding-token ngrams: . Ant]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rita'] theme:Gene_or_gene_productt/interceding-token ngrams: alternative mechanismtOe2: trigger-arg-path: mediated >nsubj >prep_for controller:Gene_or_gene_productt>e1: trigger-arg-path: bind:Binding >nsubj [lemma='rita'] themet+e1: ents2Label-mention-ngram: N-terminus oftSe1: trigger-arg-path: bind:Binding >nsubj [lemma='rita'] theme:Gene_or_gene_producttae1: trigger-arg-path: bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rita'] themetEe2: trigger-arg-path: Positive_activation >nsubj >prep_for controllert?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlledt6e1: trigger-arg-path: bind >nsubj [lemma='rita'] themet?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controller:Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn controlled:Gene_or_gene_producttOe2: trigger-arg-path: Positive_activation >nsubj >prep_for Gene_or_gene_producttde1: trigger-arg-path: Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlled:Gene_or_gene_productthe2: trigger-arg-path: Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controllertGe1: trigger-arg-path: Binding >dobj >prep_of theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: does nott9e1: trigger-arg-path: Binding >nsubj [lemma='rita'] themet-e1: ents2Label-mention-ngram: SHARED does nottinterceding-token ngrams: Antie1: trigger-arg-path: bind:Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] Gene_or_gene_productt2interceding-token ngrams: An alternative mechanismtie2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj >prep_for Gene_or_gene_productt2e1: ents2Label-mention-ngram: N-terminus of SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controllertce2: trigger-arg-path: mediated:Positive_activation >nsubj >prep_for controller:Gene_or_gene_productt:e2: trigger-arg-path: mediated >nsubj >prep_for controllertye2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp >nsubjpass >nn controlled:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controllert?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] Gene_or_gene_producttre2: trigger-arg-path: Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] Gene_or_gene_producttge2: trigger-arg-path: mediated >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: does nott.e1: args2Role-mention-ngram: the N-terminus oft7e1: trigger-arg-path: bind:Binding >dobj >prep_of themetNe1: trigger-arg-path: Binding >nsubj [lemma='rita'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt2e1: trigger-arg-path: Binding >dobj >prep_of themete2: trigger-arg-path: mediated >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] Gene_or_gene_productt?e2: trigger-arg-path: mediated >ccomp >nsubjpass >nn controlledt,e1: ents2Label-mention-ngram: the N-terminust3interceding-token ngrams: alternative mechanism fort?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='rita'] Gene_or_gene_producttTe2: trigger-arg-path: mediated >ccomp >nsubjpass >nn controlled:Gene_or_gene_productthe2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubjpass >nn controlled:Gene_or_gene_productt(interceding-token ngrams: An alternativet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rita'] Gene_or_gene_productt+e1: args2Role-mention-ngram: THEME does nottDe2: trigger-arg-path: mediated >nsubj >prep_for Gene_or_gene_productt?e2: trigger-arg-path: mediated >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlled:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of themette2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj >prep_for controller:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlledt}e2: trigger-arg-path: Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controller:Gene_or_gene_producttIe2: trigger-arg-path: mediated >ccomp >nsubjpass >nn Gene_or_gene_productt{e2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] Gene_or_gene_producttre2: trigger-arg-path: mediated >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: doestge1: trigger-arg-path: bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] theme:Gene_or_gene_productt+e1: ents2Label-mention-ngram: does not bindtIe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of themetPe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlledtMe1: trigger-arg-path: bind:Binding >nsubj [lemma='rita'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] theme:Gene_or_gene_productt'interceding-token ngrams: mechanism fortRe1: trigger-arg-path: bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] themet*e1: args2Role-mention-ngram: N-terminus oftFe1: trigger-arg-path: bind:Binding >dobj >prep_of Gene_or_gene_producttue2: trigger-arg-path: mediated >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlledtVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj >prep_of theme:Gene_or_gene_producttKe1: trigger-arg-path: bind >nsubj [lemma='rita'] theme:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] themet?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: N-terminust%e1: args2Role-mention-ngram: bind thetXe2: trigger-arg-path: mediated:Positive_activation >nsubj >prep_for Gene_or_gene_producttLe1: trigger-arg-path: bind:Binding >dobj >prep_of theme:Gene_or_gene_productt/e1: trigger-arg-path: bind >dobj >prep_of themet&e1: ents2Label-mention-ngram: bind thetEe1: trigger-arg-path: bind >nsubj [lemma='rita'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: bind the N-terminust(e1: ents2Label-mention-ngram: N-terminustJe2: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn controlledt?e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_activation >nsubj >prep_for controllert`e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >prep_for controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >prep_for Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rita'] themet0e1: args2Role-mention-ngram: N-terminus of THEMEtSe2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubjpass >nn controlledt/e1: ents2Label-mention-ngram: the N-terminus oftje1: trigger-arg-path: Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] theme:Gene_or_gene_producttqe2: trigger-arg-path: mediated:Positive_activation >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controllert)e1: args2Role-mention-ngram: not bind thetXe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn controlledt+e1: args2Role-mention-ngram: the N-terminust%interceding-token ngrams: alternativet'e1: args2Role-mention-ngram: THEME doestxe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] Gene_or_gene_productt]e2: trigger-arg-path: mediated:Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj >prep_of theme:Gene_or_gene_producttdobj [lemma='n-terminus'] >prep_of [lemma='p53'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] themetoe1: trigger-arg-path: bind:Binding >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: doest*interceding-token ngrams: . An alternativet?e2: trigger-arg-path: mediated:Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp >nsubjpass >nn controlled:Gene_or_gene_producttAe1: trigger-arg-path: Binding >dobj >prep_of Gene_or_gene_productt]e2: trigger-arg-path: mediated >nsubj [lemma='mechanism'] >prep_for [lemma='RITA'] controllertTe2: trigger-arg-path: Positive_activation >ccomp >nsubjpass >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=mediate >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] controlledt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='describe'] >nsubjpass [lemma='activation'] >nn [lemma='p53'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >prep_for controllertde1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='n-terminus'] >prep_of [lemma='p53'] themet*e1: args2Role-mention-ngram: does not bindtWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rita'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rita'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mmp'] controllert=e2: trigger-arg-path: induced >nsubj [lemma='mmp'] controllertge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mmp'] Simple_chemicaltNe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mmp'] controllertSe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mmp'] Simple_chemicalt?interceding-tokens-full-span: phenotype . While this issue has not been comprehensively addressed in RAS transformed cells , at least one study indicates that thet'e2: ents2Label-mention-ngram: 3 inducedtQe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='mmp'] controllertre2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mmp'] controller:Simple_chemicalt^e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mmp'] controller:Simple_chemicaltae2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='mmp'] controller:Simple_chemicaltVe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='mmp'] Simple_chemicalt&e2: args2Role-mention-ngram: 3 inducedtMe2: trigger-arg-path: induced >nsubj [lemma='mmp'] controller:Simple_chemicalt)e2: args2Role-mention-ngram: CONTROLLER 3tNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mmp'] Simple_chemicalt1e2: args2Role-mention-ngram: 3 induced CONTROLLEDtYe2: trigger-arg-path: Positive_regulation >nsubj [lemma='mmp'] controller:Simple_chemicaltbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mmp'] controllertBe2: trigger-arg-path: induced >nsubj [lemma='mmp'] Simple_chemicalt7e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL 3 inducedt/e2: ents2Label-mention-ngram: induced SHARED int/e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL 3t1e2: args2Role-mention-ngram: CONTROLLER 3 inducedt.e2: ents2Label-mention-ngram: 3 induced SHAREDt8e2: trigger-arg-path: Negative_activation >nn controlledt+interceding-token ngrams: degradation , viat;e1: trigger-arg-path: interacts >nsubj [lemma='ack1'] themet&interceding-token ngrams: EGFR traffictMe2: trigger-arg-path: Negative_activation >nn controlled:Gene_or_gene_producttbe2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as [lemma='gefitinib'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: inhibitors suchthe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as [lemma='gefitinib'] Gene_or_gene_productt)interceding-token ngrams: via a mechanismtXe2: trigger-arg-path: inhibitors:Negative_activation >nn controlled:Gene_or_gene_productt/interceding-token ngrams: ubiquitin binding cant/interceding-token ngrams: towards degradation .t\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='egfr'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts >prep_with [lemma='egfr'] themet!interceding-token ngrams: EGFR att$interceding-token ngrams: . A singletinterceding-token ngrams: via atge2: trigger-arg-path: inhibitors:Negative_activation >nn [lemma='egfr'] controlled:Gene_or_gene_productt)interceding-token ngrams: and making somet)interceding-token ngrams: traffic towardst.e2: args2Role-mention-ngram: kinase inhibitorst*interceding-token ngrams: EGFR degradationt%interceding-token ngrams: of the Arp2t0e2: ents2Label-mention-ngram: inhibitors such astHe1: trigger-arg-path: Binding >nsubj [lemma='ack1'] Gene_or_gene_productt5e1: args2Role-mention-ngram: with ubiquitinated THEMEt/e2: trigger-arg-path: inhibitors >nn controlledt8interceding-token ngrams: prolonging mitogenic signalingtge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='egfr'] Gene_or_gene_productt%interceding-token ngrams: and 3 basedt,interceding-token ngrams: EGFR degradation ,txe2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn [lemma='egfr'] controlled:Gene_or_gene_productt&interceding-token ngrams: 3 regulatoryt*interceding-token ngrams: between Arp2 andtinterceding-token ngrams: ACK1t!interceding-token ngrams: traffict/e2: args2Role-mention-ngram: inhibitors such ast+e1: ents2Label-mention-ngram: ubiquitinatedtQe2: trigger-arg-path: Negative_activation >nn [lemma='egfr'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ack1'] Gene_or_gene_productt*interceding-token ngrams: providing a linkt0interceding-token ngrams: some cancers resistantt interceding-token ngrams: makingt&interceding-token ngrams: link betweent2interceding-token ngrams: that abrogates ubiquitint/interceding-token ngrams: binding can stabilizetTe1: trigger-arg-path: interacts >prep_with [lemma='egfr'] theme:Gene_or_gene_producttinterceding-token ngrams: . At^e2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as [lemma='gefitinib'] controllert)interceding-token ngrams: facilitate EGFRt#interceding-token ngrams: involvingt#interceding-token ngrams: resistantt?e2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as [lemma='gefitinib'] controller:Gene_or_gene_productt-interceding-token ngrams: ACK1 that abrogatestNe1: trigger-arg-path: Binding >nsubj [lemma='ack1'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='egfr'] theme:Gene_or_gene_productt$interceding-token ngrams: Arp2 and 3t%interceding-token ngrams: cortactin ,tce2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn [lemma='egfr'] controlledt,interceding-token ngrams: actin dynamics andtYe2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn [lemma='egfr'] Gene_or_gene_productt/e2: args2Role-mention-ngram: such as CONTROLLERt&interceding-token ngrams: in ACK1 thattve2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as [lemma='gefitinib'] controller:Gene_or_gene_productt+interceding-token ngrams: dynamics and EGFRtUe2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn controlled:Gene_or_gene_productt+interceding-token ngrams: can stabilize thet.interceding-token ngrams: cancers resistant tot9e1: args2Role-mention-ngram: interacts with ubiquitinatedt1interceding-token ngrams: , potentially providingt'interceding-token ngrams: , potentiallyt3interceding-token ngrams: mitogenic signaling aftert&interceding-token ngrams: between Arp2t.interceding-token ngrams: EGFR traffic towardst?interceding-tokens-full-span: to facilitate EGFR degradation , via a mechanism involving phosphorylation of the Arp2 and 3 regulatory protein , cortactin , potentially providing a link between Arp2 and 3 based actin dynamics and EGFR traffic towards degradation . A single somatic mutation in ACK1 that abrogates ubiquitin binding can stabilize the EGFR at the plasma membrane , thereby prolonging mitogenic signaling after EGF stimulation and making some cancers resistant tot-interceding-token ngrams: EGF stimulation andt9e2: args2Role-mention-ngram: CONTROLLED kinase inhibitorst1interceding-token ngrams: potentially providing at@e2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn controlledt3e2: args2Role-mention-ngram: kinase inhibitors suchtLe2: trigger-arg-path: Negative_activation >prep_such_as Gene_or_gene_producttMe2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as controllertSe2: trigger-arg-path: inhibitors >nn [lemma='egfr'] controlled:Gene_or_gene_productt"interceding-token ngrams: Arp2 andtRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ack1'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn [lemma='egfr'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn controlledtDe2: trigger-arg-path: inhibitors >nn controlled:Gene_or_gene_productt#interceding-token ngrams: after EGFt+interceding-token ngrams: cancers resistanttinterceding-token ngrams: and 3t%interceding-token ngrams: binding cant/interceding-token ngrams: a mechanism involvingt,interceding-token ngrams: regulatory proteint'interceding-token ngrams: stabilize thetGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='egfr'] themetTe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as Gene_or_gene_producttinterceding-token ngrams: Arp2tse2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as controller:Gene_or_gene_productt&interceding-token ngrams: dynamics andtinterceding-token ngrams: linktCe2: trigger-arg-path: inhibitors:Negative_activation >nn controlledt%interceding-token ngrams: based actintCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ack1'] themet5e2: ents2Label-mention-ngram: as GENE_OR_GENE_PRODUCTtMe2: trigger-arg-path: inhibitors:Negative_activation >nn Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn controlled:Gene_or_gene_productt/e1: args2Role-mention-ngram: with ubiquitinatedt!interceding-token ngrams: , via atCe2: trigger-arg-path: inhibitors >prep_such_as Gene_or_gene_productt+interceding-token ngrams: link between Arp2t.interceding-token ngrams: 3 regulatory proteintDe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinase inhibitorst.interceding-token ngrams: , thereby prolongingt%interceding-token ngrams: the EGFR att/e2: ents2Label-mention-ngram: kinase inhibitorst\e2: trigger-arg-path: inhibitors:Negative_activation >nn [lemma='egfr'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ack1'] themetie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ack1'] theme:Gene_or_gene_productt-interceding-token ngrams: protein , cortactint)interceding-token ngrams: signaling aftertGe2: trigger-arg-path: Negative_activation >nn [lemma='egfr'] controlledtVe2: trigger-arg-path: Negative_activation >prep_such_as [lemma='gefitinib'] controllert.interceding-token ngrams: prolonging mitogenictRe1: trigger-arg-path: Binding >prep_with [lemma='egfr'] theme:Gene_or_gene_producttae2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as [lemma='gefitinib'] controllert.interceding-token ngrams: based actin dynamicstXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ack1'] theme:Gene_or_gene_productt%interceding-token ngrams: making somet^e2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as controllert`e2: trigger-arg-path: Negative_activation >prep_such_as [lemma='gefitinib'] Gene_or_gene_producttNe2: trigger-arg-path: inhibitors >prep_such_as controller:Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='egfr'] themet%interceding-token ngrams: , cortactint-interceding-token ngrams: abrogates ubiquitint#interceding-token ngrams: providingt(e2: ents2Label-mention-ngram: inhibitorstae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ack1'] theme:Gene_or_gene_productt!interceding-token ngrams: cancerst5interceding-token ngrams: traffic towards degradationt6interceding-token ngrams: thereby prolonging mitogenict_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='egfr'] Gene_or_gene_productt(interceding-token ngrams: that abrogatest+interceding-token ngrams: ubiquitin bindingt-interceding-token ngrams: towards degradationtRe2: trigger-arg-path: inhibitors:Negative_activation >nn [lemma='egfr'] controlledtme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='egfr'] theme:Gene_or_gene_producttHe2: trigger-arg-path: inhibitors >nn [lemma='egfr'] Gene_or_gene_productt-interceding-token ngrams: mechanism involvingt*e1: args2Role-mention-ngram: ubiquitinatedt'e2: args2Role-mention-ngram: inhibitorst9e1: trigger-arg-path: Binding >nsubj [lemma='ack1'] themet,interceding-token ngrams: stabilize the EGFRt*interceding-token ngrams: somatic mutationt9e2: trigger-arg-path: inhibitors >prep_such_as controllertVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='egfr'] Gene_or_gene_productt%interceding-token ngrams: EGFR at thet#interceding-token ngrams: stabilizet,interceding-token ngrams: thereby prolongingt(interceding-token ngrams: single somatict0e1: ents2Label-mention-ngram: with ubiquitinatedt/interceding-token ngrams: after EGF stimulationt'interceding-token ngrams: , cortactin ,tPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='egfr'] themetbe2: trigger-arg-path: inhibitors >prep_such_as [lemma='gefitinib'] controller:Gene_or_gene_productt"interceding-token ngrams: A singlet\e2: trigger-arg-path: Negative_activation >nn [lemma='egfr'] controlled:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn Gene_or_gene_productt'interceding-token ngrams: can stabilizetke2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as [lemma='gefitinib'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >nn [lemma='egfr'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT kinaset#interceding-token ngrams: cortactint1interceding-token ngrams: single somatic mutationt-interceding-token ngrams: signaling after EGFt!interceding-token ngrams: in ACK1tre2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as [lemma='gefitinib'] controllert*interceding-token ngrams: A single somatict&interceding-token ngrams: resistant tot&interceding-token ngrams: the Arp2 andt:e2: ents2Label-mention-ngram: such as GENE_OR_GENE_PRODUCTtEe1: ents2Label-mention-ngram: with ubiquitinated GENE_OR_GENE_PRODUCTt_e2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as controller:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ack1'] Gene_or_gene_productt,interceding-token ngrams: to facilitate EGFRt,interceding-token ngrams: membrane , therebyte2: trigger: inhibitorst)interceding-token ngrams: degradation . AtTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ack1'] themet'interceding-token ngrams: to facilitatet9e2: trigger-arg-path: inhibitors >nn Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=inhibitor >prep_such_as controllert5interceding-token ngrams: facilitate EGFR degradationt!interceding-token ngrams: somatict|e2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as [lemma='gefitinib'] Gene_or_gene_productt!interceding-token ngrams: 3 basedt.interceding-token ngrams: regulatory protein ,t*interceding-token ngrams: and EGFR traffict-interceding-token ngrams: somatic mutation int(interceding-token ngrams: a link betweent6interceding-token ngrams: involving phosphorylation oftJe1: trigger-arg-path: interacts >nsubj [lemma='ack1'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='egfr'] Gene_or_gene_productt=interceding-token ngrams: mechanism involving phosphorylationtWe2: trigger-arg-path: inhibitors:Negative_activation >prep_such_as Gene_or_gene_producttNe1: trigger-arg-path: interacts >prep_with [lemma='egfr'] Gene_or_gene_productt%interceding-token ngrams: providing at*e2: args2Role-mention-ngram: as CONTROLLERtMe2: trigger-arg-path: inhibitors >prep_such_as [lemma='gefitinib'] controllert interceding-token ngrams: a linkt:e1: ents2Label-mention-ngram: interacts with ubiquitinatedtXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='egfr'] themet4e2: ents2Label-mention-ngram: kinase inhibitors sucht$interceding-token ngrams: prolongingt*interceding-token ngrams: mutation in ACK1t#interceding-token ngrams: ACK1 thatt-e2: ents2Label-mention-ngram: inhibitors sucht-interceding-token ngrams: mitogenic signalingtBe2: trigger-arg-path: Negative_activation >prep_such_as controllert>e2: trigger-arg-path: inhibitors >nn [lemma='egfr'] controlledt/interceding-token ngrams: potentially providingt+CSSPATH: ROOT  ++ ROOT >dep >xcomp >prep_totOe2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn [lemma='egfr'] controlledt0interceding-token ngrams: stimulation and makingtJe2: trigger-arg-path: lemmatizedTrigger=inhibitor >nn Gene_or_gene_productt5interceding-token ngrams: abrogates ubiquitin bindingt interceding-token ngrams: singlet0e1: args2Role-mention-ngram: ubiquitinated THEMEtinterceding-token ngrams: , viat-interceding-token ngrams: making some cancerstWe2: trigger-arg-path: Negative_activation >prep_such_as controller:Gene_or_gene_productt(interceding-token ngrams: actin dynamicst1interceding-token ngrams: cortactin , potentiallytWe2: trigger-arg-path: inhibitors >prep_such_as [lemma='gefitinib'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=inhibitor:Negative_activation >prep_such_as Gene_or_gene_productt$interceding-token ngrams: and makingt%interceding-token ngrams: potentiallyt"interceding-token ngrams: the Arp2t*interceding-token ngrams: and 3 regulatoryt&interceding-token ngrams: some cancerst'interceding-token ngrams: 3 based actintke2: trigger-arg-path: Negative_activation >prep_such_as [lemma='gefitinib'] controller:Gene_or_gene_productt3interceding-token ngrams: involving phosphorylationtPe1: trigger-arg-path: interacts >nsubj [lemma='ack1'] theme:Gene_or_gene_productt@e1: ents2Label-mention-ngram: ubiquitinated GENE_OR_GENE_PRODUCTt~e1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicaltle1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert e2: args2Role-mention-ngram: pertle2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllertne1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert0e1: ents2Label-mention-ngram: inhibit the SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt/e1: ents2Label-mention-ngram: SHARED levels pertke1: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt*e1: args2Role-mention-ngram: levels per setie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controller:Simple_chemicalt(e2: ents2Label-mention-ngram: levels pert`e2: trigger-arg-path: Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt,e2: args2Role-mention-ngram: not inhibit thet!e2: args2Role-mention-ngram: needtre1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn Simple_chemicalt(e1: args2Role-mention-ngram: se need nott*e2: args2Role-mention-ngram: levels per set'e2: args2Role-mention-ngram: levels pert|e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicaltCe2: trigger-arg-path: inhibit >nsubj >nn controller:Simple_chemicalt$e1: ents2Label-mention-ngram: per set?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltke2: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltpe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltGe2: trigger-arg-path: inhibit:Negative_activation >nsubj >nn controllert$e2: ents2Label-mention-ngram: per set)e2: ents2Label-mention-ngram: not inhibittfe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledtze1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt0e2: ents2Label-mention-ngram: inhibit the SHAREDt^e2: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt.e2: args2Role-mention-ngram: CONTROLLER levelst-e1: ents2Label-mention-ngram: not inhibit thet_e2: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltZe2: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert8e2: trigger-arg-path: inhibit >nsubj >nn Simple_chemicaltve2: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicaltie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn controller:Simple_chemicalt|e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt-e2: args2Role-mention-ngram: need not inhibitt+e2: ents2Label-mention-ngram: SHARED levelst"e1: ents2Label-mention-ngram: needt+e2: ents2Label-mention-ngram: levels per setUe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >nn controller:Simple_chemicaltfe1: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert(e1: ents2Label-mention-ngram: levels pert{e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt.e1: ents2Label-mention-ngram: need not inhibittLe2: trigger-arg-path: inhibit:Negative_activation >nsubj >nn Simple_chemicalt#e1: args2Role-mention-ngram: per set/e2: ents2Label-mention-ngram: SHARED levels pert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: levels pertZe1: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllertie1: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt)e2: ents2Label-mention-ngram: per se needtWe1: trigger-arg-path: inhibit:Negative_activation >nsubj >nn controller:Simple_chemicalt#e2: args2Role-mention-ngram: per set?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt2e2: args2Role-mention-ngram: CONTROLLER levels pert)e1: ents2Label-mention-ngram: not inhibitt3e2: args2Role-mention-ngram: inhibit the CONTROLLEDt e1: ents2Label-mention-ngram: set{e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: inhibit:Negative_activation >nsubj >nn Simple_chemicalt!e1: ents2Label-mention-ngram: pert"e2: ents2Label-mention-ngram: needt}e2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt(e2: args2Role-mention-ngram: not inhibitt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn Simple_chemicalt^e1: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_producttje2: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt3e2: trigger-arg-path: inhibit >nsubj >nn controllert)e2: ents2Label-mention-ngram: se need nott+e1: ents2Label-mention-ngram: levels per setve1: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt$e1: args2Role-mention-ngram: se needtDe1: trigger-arg-path: Negative_activation >nsubj >nn Simple_chemicalt+e1: ents2Label-mention-ngram: SHARED levelsthe2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt e2: ents2Label-mention-ngram: set?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productte1: args2Role-mention-ngram: set-e1: args2Role-mention-ngram: need not inhibittne2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllertTe2: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt%e2: ents2Label-mention-ngram: se needt_e1: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltze2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledtTe1: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt(e2: args2Role-mention-ngram: per se needtpe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: per se needtie2: trigger-arg-path: inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert.e1: args2Role-mention-ngram: CONTROLLER levelstse2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt(e1: args2Role-mention-ngram: not inhibitt8e1: trigger-arg-path: inhibit >nsubj >nn Simple_chemicalt!e1: args2Role-mention-ngram: needt%e2: args2Role-mention-ngram: need nott2e1: args2Role-mention-ngram: CONTROLLER levels perte2: args2Role-mention-ngram: set}e1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_producttje1: trigger-arg-path: inhibit >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt"shortest-path: dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt%e1: ents2Label-mention-ngram: se needt)e1: ents2Label-mention-ngram: se need nottDe2: trigger-arg-path: Negative_activation >nsubj >nn Simple_chemicaltje2: trigger-arg-path: Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_producttOe1: trigger-arg-path: Negative_activation >nsubj >nn controller:Simple_chemicalt(e2: args2Role-mention-ngram: se need nott?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllert$e2: args2Role-mention-ngram: se needt^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >nn Simple_chemicaltfe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='phenotype'] >nn [lemma='emt'] controlledt e1: args2Role-mention-ngram: pert%e1: args2Role-mention-ngram: need nott.e2: ents2Label-mention-ngram: need not inhibittCe1: trigger-arg-path: inhibit >nsubj >nn controller:Simple_chemicalt&e2: ents2Label-mention-ngram: need nottre2: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: not inhibit thet~e2: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt&e1: ents2Label-mention-ngram: need nottse1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicaltfe2: trigger-arg-path: Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controllertOe2: trigger-arg-path: Negative_activation >nsubj >nn controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] controller:Simple_chemicalt(e1: args2Role-mention-ngram: per se needtWe2: trigger-arg-path: inhibit:Negative_activation >nsubj >nn controller:Simple_chemicaltue2: trigger-arg-path: Negative_activation >dobj [lemma='phenotype'] >nn [lemma='emt'] controlled:Gene_or_gene_productt,e1: args2Role-mention-ngram: not inhibit thet?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='level'] >nn [lemma='8-oxoguanine'] Simple_chemicalt3interceding-token ngrams: phosphorylation at Thr453tye2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlled:Gene_or_gene_productt8e2: trigger-arg-path: modulate >dobj >prep_of controllert(interceding-token ngrams: . According totTe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj >prep_of Gene_or_gene_productt*e1: args2Role-mention-ngram: and Thr739 byt9e2: args2Role-mention-ngram: modulate the transactivationtne2: trigger-arg-path: modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >prep_of controller:Gene_or_gene_productt(interceding-token ngrams: Kazal motifs (t.interceding-token ngrams: binds preferentiallytinterceding-token ngrams: Kazalt!interceding-token ngrams: , bindstdobj >prep_of controlled:Gene_or_gene_productt)interceding-token ngrams: these studies ,tae2: trigger-arg-path: modulate:Positive_activation >dobj >prep_of controller:Gene_or_gene_productt'interceding-token ngrams: in interphaset?e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlled:Gene_or_gene_productt,interceding-token ngrams: According to theset-interceding-token ngrams: then recruits HDAC1t"interceding-token ngrams: ( RECK )tue2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] Gene_or_gene_productt'interceding-token ngrams: the reversiont interceding-token ngrams: Thr453t*interceding-token ngrams: to the reversiont.e1: ents2Label-mention-ngram: , phosphorylatedtae2: trigger-arg-path: modulate:Positive_activation >dobj >prep_of controlled:Gene_or_gene_producttye2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controller:Gene_or_gene_productt'interceding-token ngrams: motifs ( RECKt1interceding-token ngrams: binds preferentially tot(interceding-tokens-full-span: , binds preferentially to the reversion inducing cysteine rich protein with Kazal motifs ( RECK ) promoter , and then recruits HDAC1 to silence RECK gene expression . According to these studies , phosphorylation at Thr453 and Thr739 by ERK1 and 2 in interphase mightt#interceding-token ngrams: Thr739 byt?e2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlled:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controllert6e1: ents2Label-mention-ngram: phosphorylated at Thr453the2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >prep_of Gene_or_gene_producttde2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controllert$interceding-token ngrams: to silencet.interceding-token ngrams: RECK gene expressiont%e2: args2Role-mention-ngram: modulatet#e1: args2Role-mention-ngram: Thr739tMe2: trigger-arg-path: modulate >dobj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controller:Gene_or_gene_productt&interceding-token ngrams: ) promoter ,t)e2: args2Role-mention-ngram: modulate thet&interceding-token ngrams: Kazal motifst0interceding-token ngrams: the reversion inducingt(interceding-token ngrams: recruits HDAC1t-interceding-token ngrams: in interphase mighttMe2: trigger-arg-path: modulate >dobj >prep_of controlled:Gene_or_gene_productt*interceding-token ngrams: to these studiest$interceding-token ngrams: interphaset interceding-token ngrams: ( RECKt'interceding-token ngrams: these studiest?e2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controller:Gene_or_gene_productt-e2: ents2Label-mention-ngram: transactivationt0interceding-token ngrams: expression . Accordingtge1: trigger-arg-path: phosphorylated:Positive_regulation dobj [lemma='activity'] >prep_of [lemma='sp1'] Gene_or_gene_productt*interceding-token ngrams: HDAC1 to silencet/e1: ents2Label-mention-ngram: Thr453 and Thr739tYe2: trigger-arg-path: modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlledt,e2: args2Role-mention-ngram: transactivationt1e1: ents2Label-mention-ngram: , phosphorylated att3interceding-token ngrams: studies , phosphorylationt&e2: ents2Label-mention-ngram: modulatet0interceding-token ngrams: inducing cysteine richt'e1: args2Role-mention-ngram: and Thr739tLe2: trigger-arg-path: modulate:Positive_activation >dobj >prep_of controlledte2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlledt+interceding-token ngrams: recruits HDAC1 tot6e2: ents2Label-mention-ngram: transactivation activityt#interceding-token ngrams: RECK genet_e2: trigger-arg-path: lemmatizedTrigger=modulate >dobj >prep_of controlled:Gene_or_gene_producttBe2: trigger-arg-path: modulate >dobj >prep_of Gene_or_gene_productt9e2: args2Role-mention-ngram: the transactivation activityt9e2: ents2Label-mention-ngram: transactivation activity oft/interceding-token ngrams: preferentially to thetMe1: trigger-arg-path: Positive_regulation dobj [lemma='activity'] >prep_of [lemma='sp1'] Gene_or_gene_productt5e2: args2Role-mention-ngram: transactivation activityt.interceding-token ngrams: , phosphorylation att5interceding-token ngrams: reversion inducing cysteinetJe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj >prep_of controlledt'interceding-token ngrams: and Thr739 byt#interceding-token ngrams: Accordingt interceding-token ngrams: RECK )t$interceding-token ngrams: with Kazalt&interceding-token ngrams: silence RECKt#interceding-token ngrams: at Thr453t5e1: ents2Label-mention-ngram: SHARED , phosphorylatedt1e2: ents2Label-mention-ngram: the transactivationt&interceding-token ngrams: rich proteinte2: trigger: modulatetme2: trigger-arg-path: modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlledt)interceding-token ngrams: 2 in interphaset+interceding-token ngrams: preferentially tot,interceding-token ngrams: reversion inducingt:e2: ents2Label-mention-ngram: modulate the transactivationtVe2: trigger-arg-path: modulate:Positive_activation >dobj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controller:Gene_or_gene_productt0interceding-token ngrams: , binds preferentiallyt+e1: ents2Label-mention-ngram: and Thr739 byt_e2: trigger-arg-path: lemmatizedTrigger=modulate >dobj >prep_of controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: Thr739 by CONTROLLERtCe1: trigger-arg-path: phosphorylated dobj [lemma='activity'] >prep_of [lemma='sp1'] controlled:Gene_or_gene_productt$interceding-token ngrams: , and thent^e2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj >prep_of controlledt#interceding-token ngrams: reversiont+interceding-token ngrams: , phosphorylationtYe2: trigger-arg-path: modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controllert)interceding-token ngrams: RECK ) promotert"interceding-token ngrams: HDAC1 tot*CSSPATH: ROOT >ccomp >nsubj >vmod ++ ROOT t(interceding-token ngrams: Thr739 by ERK1t+interceding-token ngrams: Thr453 and Thr739t8e2: trigger-arg-path: modulate >dobj >prep_of controlledt"interceding-token ngrams: to theset'interceding-token ngrams: at Thr453 andt+interceding-token ngrams: silence RECK genet+e1: ents2Label-mention-ngram: at Thr453 andtme1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj >prep_of controllerte2: trigger-arg-path: lemmatizedTrigger=modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controllert$interceding-token ngrams: ) promotertJe2: trigger-arg-path: lemmatizedTrigger=modulate >dobj >prep_of controllertde2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlledtke2: trigger-arg-path: lemmatizedTrigger=modulate >dobj [lemma='activity'] >prep_of [lemma='sp1'] controlledt%interceding-token ngrams: by ERK1 andtSe1: trigger-arg-path: phosphorylated dobj [lemma='activity'] >prep_of [lemma='sp1'] Gene_or_gene_producttWe1: trigger-arg-path: phosphorylated:Positive_regulation dobj [lemma='activity'] >prep_of [lemma='sp1'] controlled:Gene_or_gene_productt&interceding-token ngrams: protein witht0e2: args2Role-mention-ngram: the transactivationtne2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] Gene_or_gene_producttme2: trigger-arg-path: modulate:Positive_activation >dobj [lemma='activity'] >prep_of [lemma='sp1'] controllert&interceding-token ngrams: According totTe1: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj >prep_of controllertHe1: trigger-arg-path: Positive_regulation agent [lemma='pak1'] controllert-e1: ents2Label-mention-ngram: specifically byte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_productt7e2: ents2Label-mention-ngram: physically interacts withtce1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='pak1'] Gene_or_gene_productt.e1: args2Role-mention-ngram: , specifically byt&e1: ents2Label-mention-ngram: might bet7e1: args2Role-mention-ngram: specifically by CONTROLLERtOe2: trigger-arg-path: phosphorylates >nsubj [lemma='pak1'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='pak1'] Gene_or_gene_producttZe2: trigger-arg-path: phosphorylates >nsubj [lemma='pak1'] controller:Gene_or_gene_producttnsubj [lemma='pak1'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: physicallytje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pak1'] controllert?interceding-tokens-full-span: . It was previously reported thatt9e2: ents2Label-mention-ngram: SHARED physically interactst'e2: args2Role-mention-ngram: physicallyt(e1: ents2Label-mention-ngram: during SIStVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='pak1'] controllertne1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='pak1'] controller:Gene_or_gene_productt2e1: args2Role-mention-ngram: CONTROLLED during SISt'e1: args2Role-mention-ngram: during SIStOe1: trigger-arg-path: phosphorylated >agent [lemma='pak1'] Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pak1'] controllert+e1: args2Role-mention-ngram: , specificallytTe1: trigger-arg-path: Positive_regulation >agent [lemma='pak1'] Gene_or_gene_producttEe2: trigger-arg-path: phosphorylates >nsubj [lemma='pak1'] controllert e1: args2Role-mention-ngram: SISt1interceding-token ngrams: was previously reportedtje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='pak1'] controllertke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pak1'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: , specifically byt0e1: ents2Label-mention-ngram: SIS , specificallyt/e1: args2Role-mention-ngram: SIS , specificallyte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='pak1'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: during SIS ,t_e1: trigger-arg-path: Positive_regulation >agent [lemma='pak1'] controller:Gene_or_gene_producttYe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak1'] controllert/e2: ents2Label-mention-ngram: SHARED physicallyt3e1: ents2Label-mention-ngram: phosphorylated duringt2e2: args2Role-mention-ngram: CONTROLLER physicallyt6e1: ents2Label-mention-ngram: be phosphorylated duringt$interceding-token ngrams: previouslyt$e1: ents2Label-mention-ngram: duringt.e1: args2Role-mention-ngram: CONTROLLED duringt+interceding-token ngrams: It was previouslyt2interceding-token ngrams: previously reported thatt#e1: args2Role-mention-ngram: duringt,e1: args2Role-mention-ngram: specifically bytEe1: trigger-arg-path: phosphorylated >agent [lemma='pak1'] controllertJe1: trigger-arg-path: Positive_regulation >agent [lemma='pak1'] controllertte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='pak1'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='pak1'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: physically interactstne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak1'] controller:Gene_or_gene_productt(interceding-token ngrams: was previouslytce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='pak1'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: SISt2e2: ents2Label-mention-ngram: physically interactstZe1: trigger-arg-path: phosphorylated >agent [lemma='pak1'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: during SIS ,t4e1: ents2Label-mention-ngram: specifically by SHAREDt6e2: args2Role-mention-ngram: physically interacts witht,e1: ents2Label-mention-ngram: , specificallyt5e1: ents2Label-mention-ngram: might be phosphorylatedt-e1: ents2Label-mention-ngram: SHARED might bet"e1: args2Role-mention-ngram: SIS ,t-interceding-token ngrams: previously reportedt#e1: ents2Label-mention-ngram: SIS ,t7e1: ents2Label-mention-ngram: phosphorylated during SISt8e2: ents2Label-mention-ngram: can directly phosphorylatetinterceding-token ngrams: H9c2tSe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='erk1'] controllert$interceding-token ngrams: it is thustinterceding-token ngrams: ( Pthe1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='erk1'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: S15 phosphorylationtke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='erk1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='erk1'] controllert*e2: ents2Label-mention-ngram: can directlytbe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='erk1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: induced SHARED S15tDe1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='erk1'] controller:Gene_or_gene_productt&interceding-token ngrams: not followedt]e1: trigger-arg-path: induced:Positive_regulation nsubj [lemma='erk1'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: SHARED S15t#interceding-token ngrams: thus verytinterceding-token ngrams: S15t'interceding-token ngrams: in H9c2 cellst.e1: trigger-arg-path: induced nsubj [lemma='erk1'] Gene_or_gene_productt4e2: args2Role-mention-ngram: can directly CONTROLLEDt interceding-token ngrams: S15 istne1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='erk1'] controllert8e1: ents2Label-mention-ngram: SHARED S15 phosphorylationt&interceding-token ngrams: H9c2 cells .tJe1: trigger-arg-path: Positive_regulation nsubj [lemma='erk1'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: 2 can directlytOe1: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='erk1'] controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: 2 can directlytinterceding-token ngrams: P )tDe2: trigger-arg-path: phosphorylate >nsubj [lemma='erk1'] controllert,interceding-token ngrams: very unlikely thattXe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='erk1'] controllert>e1: trigger-arg-path: induced nsubj [lemma='erk1'] controller:Gene_or_gene_producttnsubj [lemma='erk1'] Gene_or_gene_productt6e2: ents2Label-mention-ngram: phosphorylate SHARED S15t`e1: trigger-arg-path: Positive_regulation prep_between [lemma='bcl-2'] FamilytUe1: trigger-arg-path: interaction >prep_between [lemma='fkbp38'] Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb'] theme:Gene_or_gene_producttFe1: trigger-arg-path: interaction >prep_between [lemma='fkbp38'] themet'e1: args2Role-mention-ngram: THEME ( antMe1: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-2'] themetLe2: trigger-arg-path: binds >nsubj [lemma='rheb'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: the antiapoptotic proteint.e1: args2Role-mention-ngram: the antiapoptotict.e1: args2Role-mention-ngram: inhibitor of mTORtLe1: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] theme:FamilytQe1: trigger-arg-path: Binding >prep_between [lemma='fkbp38'] Gene_or_gene_productt,e1: args2Role-mention-ngram: between THEME (t_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fkbp38'] theme:Gene_or_gene_producttFe2: trigger-arg-path: binds >nsubj [lemma='rheb'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fkbp38'] themet,e1: ents2Label-mention-ngram: ( an inhibitort'e1: args2Role-mention-ngram: mTOR ) andtfe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] theme:FamilytEe1: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] themet%interceding-token ngrams: While boundtHe2: trigger-arg-path: Binding >nsubj [lemma='rheb'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='rheb'] themetWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] themet8e1: args2Role-mention-ngram: antiapoptotic protein THEMEt?e2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb'] themet$e1: ents2Label-mention-ngram: mTOR )tFe1: trigger-arg-path: interaction >prep_between [lemma='bcl-2'] Familyt"e1: ents2Label-mention-ngram: ( antXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fkbp38'] themet'interceding-token ngrams: . While boundt&interceding-token ngrams: bound to GTPt2e1: args2Role-mention-ngram: and the antiapoptotict[e1: trigger-arg-path: interaction >prep_between [lemma='fkbp38'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: antiapoptotict&e1: args2Role-mention-ngram: of mTOR )t^e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] theme:Familyt6e1: args2Role-mention-ngram: the antiapoptotic proteint)e1: args2Role-mention-ngram: an inhibitort`e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] Familyt3e1: ents2Label-mention-ngram: and the antiapoptotictWe1: trigger-arg-path: Binding >prep_between [lemma='fkbp38'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb'] themet#e1: args2Role-mention-ngram: mTOR )t]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb'] theme:Gene_or_gene_productt"interceding-token ngrams: to GTP ,tBe1: trigger-arg-path: Binding >prep_between [lemma='fkbp38'] themet)e1: ents2Label-mention-ngram: SHARED ( ant,e1: ents2Label-mention-ngram: protein FAMILYtAe1: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] themetoe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fkbp38'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='bcl-2'] Familyt/e1: ents2Label-mention-ngram: the antiapoptotictWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb'] Gene_or_gene_productt*CSSPATH: ROOT >xcomp >ccomp >dobj ++ ROOT tHe1: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] theme:FamilytHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rheb'] themetce1: trigger-arg-path: interaction:Binding >prep_between [lemma='fkbp38'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: inhibitor of mTORt7e2: trigger-arg-path: binds >nsubj [lemma='rheb'] themet'e1: ents2Label-mention-ngram: of mTOR )tue1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='fkbp38'] theme:Gene_or_gene_productt4interceding-tokens-full-span: . While bound to GTP ,t_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='bcl-2'] themetBe1: trigger-arg-path: Binding >prep_between [lemma='bcl-2'] Familytee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rheb'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='rheb'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: ( antge1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='fkbp38'] Gene_or_gene_productt"interceding-token ngrams: bound tot]e1: trigger-arg-path: interaction:Binding >prep_between [lemma='fkbp38'] Gene_or_gene_producttNe1: trigger-arg-path: interaction:Binding >prep_between [lemma='fkbp38'] themet,e1: args2Role-mention-ngram: an inhibitor oft:e1: ents2Label-mention-ngram: antiapoptotic protein FAMILYtTe1: trigger-arg-path: interaction:Binding >prep_between [lemma='bcl-2'] theme:Familyt2e1: args2Role-mention-ngram: antiapoptotic proteint+e1: args2Role-mention-ngram: ( an inhibitort3e1: ents2Label-mention-ngram: antiapoptotic proteintNe2: trigger-arg-path: binds:Binding >nsubj [lemma='rheb'] Gene_or_gene_producttde2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttDe2: trigger-arg-path: mediated >nsubj [lemma='GSK-3beta'] controllert~e2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttYe2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_productt,interceding-token ngrams: VDAC amongst othertYe2: trigger-arg-path: mediated >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='GSK-3beta'] controllertOe2: trigger-arg-path: Positive_regulation >nsubj [lemma='GSK-3beta'] controllert_e2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='GSK-3beta'] controllert*interceding-token ngrams: and VDAC amongsttme2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_productt&interceding-token ngrams: VDAC amongsttLinterceding-tokens-full-span: and VDAC amongst other mitochondrial targets .tNe2: trigger-arg-path: mediated >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttbe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='GSK-3beta'] Gene_or_gene_producttXe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='GSK-3beta'] controllert"interceding-token ngrams: and VDACtje2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='GSK-3beta'] controller:Gene_or_gene_producttinterceding-token ngrams: VDACtNe1: trigger-arg-path: Binding >nsubj [lemma='pip3'] theme:Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='akt'] Gene_or_gene_productt6interceding-token ngrams: activated by phosphorylationt6e2: ents2Label-mention-ngram: substrates including thetNe1: trigger-arg-path: binds:Binding >nsubj [lemma='pip3'] Gene_or_gene_producttUe1: trigger-arg-path: binds:Binding >prep_to [lemma='akt'] theme:Gene_or_gene_productt.interceding-token ngrams: then translocates totOe1: trigger-arg-path: binds:Binding >prep_to [lemma='akt'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='akt'] themetIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='akt'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='pip3'] Gene_or_gene_producttee2: trigger-arg-path: phosphorylates dobj [lemma='akt'] Gene_or_gene_productt@e1: trigger-arg-path: binds:Binding >prep_to [lemma='akt'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='pip3'] themetXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='akt'] Gene_or_gene_productt9e2: ents2Label-mention-ngram: SHARED substrates includingt2e2: ents2Label-mention-ngram: including the serinet7e1: trigger-arg-path: binds >nsubj [lemma='pip3'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='pip3'] themetGe1: trigger-arg-path: binds >prep_to [lemma='akt'] Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_to [lemma='akt'] Gene_or_gene_producttOe2: trigger-arg-path: phosphorylates dobj controller:Gene_or_gene_producttFe1: trigger-arg-path: binds >nsubj [lemma='pip3'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj controller:Gene_or_gene_productt?e2: trigger-arg-path: phosphorylates:Positive_regulation dobj [lemma='akt'] controller:Gene_or_gene_producttNe2: trigger-arg-path: phosphorylates:Positive_regulation dobj controllert#interceding-token ngrams: where Akttle2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj [lemma='akt'] controllert`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj controller:Gene_or_gene_productt[e2: trigger-arg-path: phosphorylates dobj [lemma='akt'] controllert)interceding-token ngrams: is activated byt?e1: trigger-arg-path: binds:Binding >nsubj [lemma='pip3'] themet>e2: ents2Label-mention-ngram: phosphorylates SHARED substratest&interceding-token ngrams: is activatedt8e1: trigger-arg-path: binds >prep_to [lemma='akt'] themet,interceding-token ngrams: membrane where Akttve2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj [lemma='akt'] Gene_or_gene_productt+interceding-token ngrams: then translocatestje2: trigger-arg-path: Positive_regulation dobj [lemma='akt'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: substratestWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='pip3'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: including thetUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='akt'] theme:Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation dobj Gene_or_gene_producttpe2: trigger-arg-path: phosphorylates dobj [lemma='akt'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: includingt?interceding-tokens-full-span: and then translocates to the plasma membrane where Akt is activated by phosphorylation . Activatedt interceding-token ngrams: Akt ist^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='akt'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj controllert&interceding-token ngrams: where Akt istee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='pip3'] theme:Gene_or_gene_productt#interceding-token ngrams: ActivatedtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='pip3'] themet:e2: trigger-arg-path: phosphorylates dobj controllertoe2: trigger-arg-path: phosphorylates:Positive_regulation dobj [lemma='akt'] controllertye2: trigger-arg-path: phosphorylates:Positive_regulation dobj [lemma='akt'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_to [lemma='akt'] themetTe1: trigger-arg-path: binds:Binding >nsubj [lemma='pip3'] theme:Gene_or_gene_producttXe2: trigger-arg-path: phosphorylates:Positive_regulation dobj Gene_or_gene_producttMe1: trigger-arg-path: binds >prep_to [lemma='akt'] theme:Gene_or_gene_productt5interceding-token ngrams: phosphorylation . Activatedt%interceding-token ngrams: . ActivatedtLe1: trigger-arg-path: binds >nsubj [lemma='pip3'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj Gene_or_gene_productt/e2: ents2Label-mention-ngram: SHARED substratest?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj [lemma='akt'] controller:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='pip3'] theme:Gene_or_gene_producttDe2: trigger-arg-path: phosphorylates dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate dobj [lemma='akt'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: substrates includingtue2: trigger-arg-path: Positive_regulation dobj [lemma='akt'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj [lemma='akt'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation dobj controllert.interceding-token ngrams: by phosphorylation .t`e2: trigger-arg-path: Positive_regulation dobj [lemma='akt'] controllert/interceding-token ngrams: and then translocatestOe1: trigger-arg-path: Binding >prep_to [lemma='akt'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj [lemma='akt'] controllertHe1: trigger-arg-path: Binding >nsubj [lemma='pip3'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation dobj controllertce2: trigger-arg-path: phosphorylates:Positive_regulation dobj controller:Gene_or_gene_productt*interceding-token ngrams: Akt is activatedtTe2: trigger-arg-path: Positive_regulation dobj controller:Gene_or_gene_producttbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_producttLe2: trigger-arg-path: inhibited >dobj [lemma='ubiquitination'] Generic_eventtpe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] Generic_eventt?e2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] Gene_or_gene_producttfe2: trigger-arg-path: Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controllertYe1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] controlledt/e2: ents2Label-mention-ngram: Akt inhibited thet{e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventt>e2: trigger-arg-path: inhibited >dobj controlled:Generic_eventt*interceding-token ngrams: from insulin wasthe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of Gene_or_gene_productt*interceding-token ngrams: FKHR degradationt%interceding-token ngrams: by the PI3Ktze2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] Gene_or_gene_producttinterceding-token ngrams: FKHRtge1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] controlled:Generic_eventt/interceding-token ngrams: FKHR degradation fromtqe2: trigger-arg-path: inhibited >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controller:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of Gene_or_gene_productt#interceding-token ngrams: signal tot"interceding-token ngrams: the PI3Ktfe2: trigger-arg-path: inhibited >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] Gene_or_gene_productt#interceding-token ngrams: the cellst*e2: args2Role-mention-ngram: Akt inhibitedt(interceding-token ngrams: PI3K pathway ,tJe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of controllert2interceding-token ngrams: degradation from insulintpe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='ubiquitination'] Generic_eventtve2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] Gene_or_gene_productt)interceding-token ngrams: the mutation oft$interceding-token ngrams: cells . Int*e2: ents2Label-mention-ngram: or threoninet1e2: ents2Label-mention-ngram: serine or threoninetme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='ubiquitination'] controlledt(interceding-token ngrams: to be mediatedt3e2: ents2Label-mention-ngram: phosphorylated by Aktt*interceding-token ngrams: and the mutationt_e1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] Generic_eventtse2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt`e2: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='ubiquitination'] Generic_eventtMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] controllert:e2: trigger-arg-path: inhibited >nsubj >prep_of controllert5e2: args2Role-mention-ngram: inhibited the CONTROLLEDt/e2: args2Role-mention-ngram: threonine residuest?e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT enhances thetSe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='insulin'] controllert*e2: args2Role-mention-ngram: at the serinet&interceding-token ngrams: , the signaltDe2: trigger-arg-path: inhibited >nsubj >prep_of Gene_or_gene_productt]e2: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='ubiquitination'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controller:Gene_or_gene_productt?e2: ents2Label-mention-ngram: threonine residues phosphorylatedt|e1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: Akt inhibitedt>e2: args2Role-mention-ngram: threonine residues phosphorylatedt0e2: args2Role-mention-ngram: serine or threoninet$e2: ents2Label-mention-ngram: by Aktt&e2: args2Role-mention-ngram: serine ort\e2: trigger-arg-path: inhibited >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controllertWe2: trigger-arg-path: inhibited >dobj [lemma='ubiquitination'] controlled:Generic_eventtme1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >dobj [lemma='ubiquitination'] controlledtWe1: trigger-arg-path: enhances >nsubj [lemma='insulin'] controller:Gene_or_gene_productt*interceding-token ngrams: the PI3K pathwaytNe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj controlled:Generic_eventtpe2: trigger-arg-path: Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] Gene_or_gene_productt'e2: ents2Label-mention-ngram: serine ortIe2: trigger-arg-path: inhibited >dobj [lemma='ubiquitination'] controlledtae2: trigger-arg-path: Negative_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventt!interceding-token ngrams: to FKHRthe1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='insulin'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: or threonine residuest+e2: ents2Label-mention-ngram: at the serinet&interceding-token ngrams: PI3K pathwayt9e1: ents2Label-mention-ngram: enhances the ubiquitinationt\e1: trigger-arg-path: lemmatizedTrigger=enhance >dobj [lemma='ubiquitination'] Generic_eventtae1: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventtOe2: trigger-arg-path: inhibited >nsubj >prep_of controller:Gene_or_gene_productt'interceding-token ngrams: pathway , andtke1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_productt$interceding-token ngrams: the signalt&interceding-token ngrams: in the cellst:e2: ents2Label-mention-ngram: inhibited the ubiquitinationt*interceding-token ngrams: degradation fromt?interceding-tokens-full-span: in the cells . In addition , the signal to FKHR degradation from insulin was shown to be mediated by the PI3K pathway , and the mutation oft.e2: ents2Label-mention-ngram: by Akt inhibitedt`e1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt*e2: args2Role-mention-ngram: inhibited thet*e2: args2Role-mention-ngram: the serine ort4e2: args2Role-mention-ngram: residues phosphorylatedtNe2: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of controllertWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt'interceding-token ngrams: the signal totBe1: trigger-arg-path: enhances >nsubj [lemma='insulin'] controllert&interceding-token ngrams: the mutationt(interceding-token ngrams: signal to FKHRtqe1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitination'] Generic_eventt)e2: args2Role-mention-ngram: or threoninetje1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventtge2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitination'] controlled:Generic_eventt.e2: args2Role-mention-ngram: Akt inhibited thet#e2: args2Role-mention-ngram: by Aktt\e1: trigger-arg-path: enhances:Positive_regulation >dobj [lemma='ubiquitination'] controlledt+interceding-token ngrams: insulin was shownt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controller:Gene_or_gene_producttVe1: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] controlled:Generic_eventtVe1: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='insulin'] controllert)interceding-token ngrams: mediated by thet%interceding-token ngrams: insulin wast_e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj >prep_of controller:Gene_or_gene_producttRe2: trigger-arg-path: inhibited:Negative_regulation >dobj controlled:Generic_eventtHe1: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] controlledtWe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj Generic_eventtKe1: trigger-arg-path: enhances >dobj [lemma='ubiquitination'] Generic_eventtpe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controllert+e2: ents2Label-mention-ngram: the serine ort4e1: args2Role-mention-ngram: CONTROLLER enhances thet&interceding-token ngrams: from insulintCe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj Generic_eventt+e2: ents2Label-mention-ngram: inhibited thetXe2: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of Gene_or_gene_producttce2: trigger-arg-path: inhibited:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt3e2: trigger-arg-path: inhibited >dobj Generic_eventtGe2: trigger-arg-path: inhibited:Negative_regulation >dobj Generic_eventt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj >prep_of controllert{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventt]e1: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='insulin'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: residues phosphorylated byt2e2: args2Role-mention-ngram: phosphorylated by Aktt(interceding-token ngrams: be mediated bytYe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='ubiquitination'] controlledtVe1: trigger-arg-path: Positive_regulation >dobj [lemma='ubiquitination'] Generic_eventt5e2: ents2Label-mention-ngram: residues phosphorylatedtle2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controllert2e2: args2Role-mention-ngram: or threonine residuest{e2: trigger-arg-path: Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controller:Gene_or_gene_producttDe2: trigger-arg-path: inhibited:Negative_regulation >dobj controlledt%interceding-token ngrams: the cells .tge1: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='insulin'] controllertVe2: trigger-arg-path: Negative_regulation >dobj [lemma='ubiquitination'] Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='mutation'] >prep_of [lemma='fkhr'] controllertbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >dobj controlled:Generic_eventt%interceding-token ngrams: be mediatedt7e2: args2Role-mention-ngram: residues phosphorylated byt4e1: args2Role-mention-ngram: enhances the CONTROLLEDtke2: trigger-arg-path: inhibited:Negative_regulation >dobj [lemma='ubiquitination'] controlled:Generic_eventtLe1: trigger-arg-path: enhances >nsubj [lemma='insulin'] Gene_or_gene_productt-interceding-token ngrams: to FKHR degradationt-e2: args2Role-mention-ngram: by Akt inhibitedtbe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] themet-e1: ents2Label-mention-ngram: the other tumort'e1: ents2Label-mention-ngram: the othertme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt^e2: trigger-arg-path: phosphorylates >nsubj [lemma='Aurora-A'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] Gene_or_gene_producttSe2: trigger-arg-path: phosphorylates >nsubj [lemma='Aurora-A'] Gene_or_gene_producttNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='Aurora-A'] controllert_e1: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] themet,e1: ents2Label-mention-ngram: with the othertVe1: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] themetJe1: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] themetre2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='Aurora-A'] controller:Gene_or_gene_producttYe1: trigger-arg-path: interacts:Binding >prep_with [lemma='rassf1a'] Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='Aurora-A'] Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='Aurora-A'] controllert'e1: args2Role-mention-ngram: suppressortne2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='Aurora-A'] controllert"e1: args2Role-mention-ngram: tumortQe1: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] Gene_or_gene_productt]e2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='Aurora-A'] controllertLe1: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >nsubj [lemma='aurora-a'] themetje1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='rassf1a'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='Aurora-A'] Gene_or_gene_productt-e1: args2Role-mention-ngram: suppressor THEMEt,e1: args2Role-mention-ngram: the other tumort\e1: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttce2: trigger-arg-path: Positive_regulation >nsubj [lemma='Aurora-A'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='Aurora-A'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttGe1: trigger-arg-path: interacts:Binding >nsubj [lemma='aurora-a'] themet3e1: args2Role-mention-ngram: other tumor suppressortNe1: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: other tumortPe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='aurora-a'] themetBe1: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] themetWe1: trigger-arg-path: interacts >prep_with [lemma='rassf1a'] theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: other tumor suppressortge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt-e1: args2Role-mention-ngram: tumor suppressort&e1: args2Role-mention-ngram: the othertTe1: trigger-arg-path: interacts >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] theme:Gene_or_gene_producttge2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='Aurora-A'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='Aurora-A'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='Aurora-A'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='aurora-a'] themet(e1: args2Role-mention-ngram: other tumort@e1: trigger-arg-path: Binding >prep_with [lemma='rassf1a'] themet+e1: args2Role-mention-ngram: with the othertIe2: trigger-arg-path: phosphorylates >nsubj [lemma='Aurora-A'] controllert3e1: args2Role-mention-ngram: tumor suppressor THEMEtEe2: trigger-arg-path: complex >nn [lemma='vdac'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hkius'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='vdac'] Gene_or_gene_producttZinterceding-tokens-full-span: , therefore , inhibiting the exchange of small solutes . ThetDe1: trigger-arg-path: interaction >poss [lemma='its'] Generic_entityt\e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='hkius'] themetWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vdac'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vdac'] themet\e1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] theme:Generic_entityt_e1: trigger-arg-path: interaction:Binding >prep_with [lemma='hkius'] theme:Gene_or_gene_productt+interceding-token ngrams: exchange of smalltRe1: trigger-arg-path: interaction:Binding >poss [lemma='its'] theme:Generic_entityt0interceding-token ngrams: therefore , inhibitingtfe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hkius'] theme:Gene_or_gene_producttQe1: trigger-arg-path: interaction >prep_with [lemma='hkius'] Gene_or_gene_producttLe2: trigger-arg-path: complex >nn [lemma='hkius'] theme:Gene_or_gene_productt*interceding-token ngrams: of small solutest`e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hkius'] Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='vdac'] themet&interceding-token ngrams: the exchangetee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='vdac'] theme:Gene_or_gene_productt&interceding-token ngrams: , inhibitingtLe1: trigger-arg-path: interaction:Binding >poss [lemma='its'] Generic_entitytFe2: trigger-arg-path: complex >nn [lemma='hkius'] Gene_or_gene_productt6e2: trigger-arg-path: Binding >nn [lemma='vdac'] themetSe2: trigger-arg-path: complex:Binding >nn [lemma='vdac'] theme:Gene_or_gene_productt#interceding-token ngrams: solutes .tEe2: trigger-arg-path: Binding >nn [lemma='vdac'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hkius'] theme:Gene_or_gene_productt)interceding-token ngrams: small solutes .t%interceding-token ngrams: exchange oftke1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='hkius'] Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='vdac'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interaction >poss [lemma='its'] theme:Generic_entitytPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='vdac'] themetMe1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] themetCe1: trigger-arg-path: interaction:Binding >poss [lemma='its'] themetLe2: trigger-arg-path: Binding >nn [lemma='hkius'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >prep_with [lemma='hkius'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] theme:Generic_entityt"interceding-token ngrams: of smallt!interceding-token ngrams: solutest^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] Generic_entitytie1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='hkius'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding >nn [lemma='hkius'] Gene_or_gene_producttJe1: trigger-arg-path: interaction:Binding >prep_with [lemma='hkius'] themetNe2: trigger-arg-path: complex:Binding >nn [lemma='hkius'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='hkius'] Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='hkius'] theme:Gene_or_gene_productt;e1: trigger-arg-path: interaction >poss [lemma='its'] themet6e2: trigger-arg-path: complex >nn [lemma='vdac'] themet'interceding-token ngrams: small solutest#CSSPATH: ROOT >agent ++ ROOT >nsubjtKe2: trigger-arg-path: Binding >nn [lemma='vdac'] theme:Gene_or_gene_producttMe2: trigger-arg-path: complex:Binding >nn [lemma='vdac'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='hkius'] themetVe1: trigger-arg-path: lemmatizedTrigger=interaction >poss [lemma='its'] Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >poss [lemma='its'] themetTe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='hkius'] themetSe1: trigger-arg-path: Binding >prep_with [lemma='hkius'] theme:Gene_or_gene_productt)interceding-token ngrams: the exchange oftIe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='hkius'] themetTe2: trigger-arg-path: complex:Binding >nn [lemma='hkius'] theme:Gene_or_gene_productt'interceding-token ngrams: solutes . Thet1interceding-token ngrams: inhibiting the exchanget7e2: trigger-arg-path: Binding >nn [lemma='hkius'] themetYe1: trigger-arg-path: interaction:Binding >prep_with [lemma='hkius'] Gene_or_gene_productt7e2: trigger-arg-path: complex >nn [lemma='hkius'] themetWe1: trigger-arg-path: interaction >prep_with [lemma='hkius'] theme:Gene_or_gene_productt*interceding-token ngrams: , inhibiting thet]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='vdac'] theme:Gene_or_gene_productt>e1: trigger-arg-path: Binding >prep_with [lemma='hkius'] themetBe1: trigger-arg-path: interaction >prep_with [lemma='hkius'] themet?e2: trigger-arg-path: complex:Binding >nn [lemma='hkius'] themetUe2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] theme:Generic_entityt+interceding-token ngrams: PLD1 effects liket&e2: args2Role-mention-ngram: two THEMEt-interceding-token ngrams: raised the questiontge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='PEA-15'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] theme:Generic_entityt;e1: trigger-arg-path: Binding >prep_to [lemma='pld1'] themet,interceding-token ngrams: activation . Theset%interceding-token ngrams: in additiont interceding-token ngrams: PEA-15tUe1: trigger-arg-path: bind:Binding >prep_to [lemma='pld1'] theme:Gene_or_gene_productt)interceding-token ngrams: the question iftMe2: trigger-arg-path: Binding >prep_of [lemma='protein'] theme:Generic_entitytPe1: trigger-arg-path: Binding >prep_to [lemma='pld1'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='protein'] Generic_entityt'interceding-token ngrams: in iBMK cellstGe2: trigger-arg-path: Binding >prep_of [lemma='protein'] Generic_entityt"interceding-token ngrams: findingstGe1: trigger-arg-path: bind >nsubj [lemma='PEA-15'] Gene_or_gene_productt+interceding-token ngrams: These findings int/interceding-token ngrams: can impair downstreamt"interceding-token ngrams: questiont0interceding-token ngrams: PKC-alpha activation .t_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pld1'] theme:Gene_or_gene_producttinterceding-token ngrams: PLD1t0interceding-token ngrams: that PLD1 co-localizest*e2: args2Role-mention-ngram: the two THEMEt8e1: trigger-arg-path: bind >prep_to [lemma='pld1'] themet2interceding-token ngrams: co-localizes with PEA-15t)interceding-token ngrams: downstream PLD1t%e2: ents2Label-mention-ngram: the twotOe1: trigger-arg-path: bind:Binding >nsubj [lemma='PEA-15'] Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding >prep_of theme:Generic_entityt)interceding-token ngrams: addition to ourt$interceding-token ngrams: iBMK cellstUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of theme:Generic_entityt#interceding-token ngrams: PEA-15 int*interceding-token ngrams: . These findingst#interceding-token ngrams: that PLD1t.interceding-token ngrams: PKC-alpha activationtMe1: trigger-arg-path: bind >prep_to [lemma='pld1'] theme:Gene_or_gene_productt.interceding-token ngrams: findings in additiontRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='PEA-15'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='PEA-15'] theme:Gene_or_gene_productt&interceding-token ngrams: PLD1 effectstJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='PEA-15'] themet%interceding-token ngrams: our findingt+e1-label: Generic_event + e2-label: Bindingt+interceding-token ngrams: co-localizes witht0interceding-token ngrams: effects like PKC-alphatae2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] Generic_entitytPe1: trigger-arg-path: Binding >nsubj [lemma='PEA-15'] theme:Gene_or_gene_producttOe2: trigger-arg-path: binding:Binding >prep_of [lemma='protein'] Generic_entitytUe1: trigger-arg-path: bind:Binding >nsubj [lemma='PEA-15'] theme:Gene_or_gene_productt(interceding-token ngrams: with PEA-15 intDCSSPATH: ROOT >conj_and >ccomp >nsubj >prep_of ++ ROOT >advcl >nsubjtge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='protein'] theme:Generic_entitytae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='PEA-15'] Gene_or_gene_producttGe1: trigger-arg-path: bind >prep_to [lemma='pld1'] Gene_or_gene_productt!interceding-token ngrams: in iBMKt@e1: trigger-arg-path: bind:Binding >nsubj [lemma='PEA-15'] themetJe1: trigger-arg-path: Binding >nsubj [lemma='PEA-15'] Gene_or_gene_productt5e2: trigger-arg-path: Binding >prep_of Generic_entityt&interceding-token ngrams: the questiont0e2: ents2Label-mention-ngram: two GENERIC_ENTITYt;e2: trigger-arg-path: binding >prep_of theme:Generic_entityt0interceding-token ngrams: impair downstream PLD1t%interceding-token ngrams: with PEA-15t0interceding-token ngrams: PLD1 co-localizes withtOe1: trigger-arg-path: bind:Binding >prep_to [lemma='pld1'] Gene_or_gene_productt#interceding-token ngrams: PKC-alphat1interceding-token ngrams: downstream PLD1 effectst4e2: ents2Label-mention-ngram: the two GENERIC_ENTITYt;e1: trigger-arg-path: Binding >nsubj [lemma='PEA-15'] themetJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pld1'] themet$e2: args2Role-mention-ngram: the twot(interceding-token ngrams: to our findingtMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of theme:Generic_entityt$interceding-token ngrams: raised thetMe1: trigger-arg-path: bind >nsubj [lemma='PEA-15'] theme:Gene_or_gene_productt%interceding-token ngrams: question ift+interceding-token ngrams: iBMK cells raisedt+interceding-token ngrams: impair downstreamtMe2: trigger-arg-path: binding >prep_of [lemma='protein'] theme:Generic_entitytYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='PEA-15'] Gene_or_gene_productt$interceding-token ngrams: can impairtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pld1'] Gene_or_gene_productt=e2: trigger-arg-path: binding:Binding >prep_of Generic_entitytRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pld1'] themet*interceding-token ngrams: our finding thattge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pld1'] theme:Gene_or_gene_producttGe2: trigger-arg-path: binding >prep_of [lemma='protein'] Generic_entityt(interceding-token ngrams: in addition tot*interceding-token ngrams: cells raised thet interceding-token ngrams: to ourt%interceding-token ngrams: findings intYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pld1'] Gene_or_gene_productt?interceding-tokens-full-span: can impair downstream PLD1 effects like PKC-alpha activation . These findings in addition to our finding that PLD1 co-localizes with PEA-15 in iBMK cells raised the question iftJe1: trigger-arg-path: Binding >prep_to [lemma='pld1'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of Generic_entityt(e2: ents2Label-mention-ngram: of the twot;e2: trigger-arg-path: Binding >prep_of theme:Generic_entitytGe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of Generic_entitytinterceding-token ngrams: iBMKt&interceding-token ngrams: cells raisedt'e2: args2Role-mention-ngram: of the twot interceding-token ngrams: raisedt(interceding-token ngrams: These findingst3interceding-token ngrams: like PKC-alpha activationt+interceding-token ngrams: finding that PLD1t@e1: trigger-arg-path: bind:Binding >prep_to [lemma='pld1'] themet&interceding-token ngrams: co-localizest&interceding-token ngrams: effects liket+interceding-token ngrams: PLD1 co-localizest(interceding-token ngrams: PEA-15 in iBMKt8e1: trigger-arg-path: bind >nsubj [lemma='PEA-15'] themet interceding-token ngrams: impairt(interceding-token ngrams: like PKC-alphat5e2: trigger-arg-path: binding >prep_of Generic_entityt\e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='MOZ'] Gene_or_gene_productt)interceding-token ngrams: suppressing Rast&interceding-token ngrams: senescence .t$interceding-token ngrams: strategiest"interceding-token ngrams: and K382tle1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='moz'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='MOZ'] Gene_or_gene_productt2interceding-token ngrams: suppressing Ras mediatedtRe1: trigger-arg-path: induced >nsubj [lemma='moz'] controller:Gene_or_gene_productt0interceding-token ngrams: mediated tumorigenesist)interceding-token ngrams: for suppressingtde2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='MOZ'] controller:Gene_or_gene_producttRe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='MOZ'] controllert0interceding-token ngrams: senescence . Thereforet*interceding-token ngrams: via induction oft&interceding-token ngrams: Ras mediatedt2interceding-token ngrams: that selectively promotet(interceding-token ngrams: is crucial fortge2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='MOZ'] controller:Gene_or_gene_producttinterceding-token ngrams: K382t=e1: trigger-arg-path: induced >nsubj [lemma='moz'] controllertce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='MOZ'] controllert%interceding-token ngrams: suppressingtNe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='moz'] controllert1interceding-token ngrams: and cellular senescencetfe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='moz'] controller:Gene_or_gene_producttGe1: trigger-arg-path: induced >nsubj [lemma='moz'] Gene_or_gene_productt-interceding-token ngrams: for suppressing Rast[e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='moz'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='MOZ'] controllert?interceding-tokens-full-span: and K382 is crucial for suppressing Ras mediated tumorigenesis via induction of p21 and cellular senescence . Therefore , strategies that selectively promotet1e1: ents2Label-mention-ngram: induced acetylationt%interceding-token ngrams: crucial fort-interceding-token ngrams: selectively promotet%e1: ents2Label-mention-ngram: at K120tSe1: trigger-arg-path: Positive_regulation >nsubj [lemma='moz'] Gene_or_gene_productt4interceding-token ngrams: mediated tumorigenesis viat0interceding-token ngrams: Therefore , strategiestYe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='MOZ'] Gene_or_gene_productt>e2: trigger-arg-path: mediated >nsubj [lemma='MOZ'] controllert)interceding-token ngrams: K382 is crucialt+interceding-token ngrams: , strategies thatt1interceding-token ngrams: crucial for suppressingt$interceding-token ngrams: is crucialtSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='MOZ'] Gene_or_gene_productt4interceding-token ngrams: Ras mediated tumorigenesist,e1: ents2Label-mention-ngram: SHARED at K120t'interceding-token ngrams: via inductiont/interceding-token ngrams: cellular senescence .t4e1: ents2Label-mention-ngram: induced acetylation oft*interceding-token ngrams: that selectivelyt&interceding-token ngrams: , strategiestHe2: trigger-arg-path: mediated >nsubj [lemma='MOZ'] Gene_or_gene_productt+interceding-token ngrams: tumorigenesis viat1CSSPATH: ROOT >ccomp ++ ROOT >nsubj >rcmod >ccomptce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='moz'] controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='moz'] Gene_or_gene_productt!interceding-token ngrams: K382 ist*interceding-token ngrams: induction of p21tIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='MOZ'] controllertIe1: trigger-arg-path: Positive_regulation >nsubj [lemma='moz'] controllert5interceding-token ngrams: strategies that selectivelyt)interceding-token ngrams: strategies thattwe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='moz'] controller:Gene_or_gene_productt!interceding-token ngrams: crucialt%interceding-token ngrams: and K382 ist^e1: trigger-arg-path: Positive_regulation >nsubj [lemma='moz'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='MOZ'] controller:Gene_or_gene_productt*interceding-token ngrams: p21 and cellulartQe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='moz'] controllert8e1: ents2Label-mention-ngram: SHARED induced acetylationtbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='moz'] controllertSe2: trigger-arg-path: mediated >nsubj [lemma='MOZ'] controller:Gene_or_gene_productt&interceding-token ngrams: and cellulart5interceding-token ngrams: tumorigenesis via inductiont^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='MOZ'] controller:Gene_or_gene_productt-interceding-token ngrams: cellular senescencetae1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj Gene_or_gene_producttUe1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='igf2'] controllert)interceding-token ngrams: contrast , IGF2tJe1: trigger-arg-path: stimulated:Positive_regulation >dobj Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtae1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] Phosphorylationt_e1: trigger-arg-path: stimulated:Positive_regulation >dobj [lemma='phosphorylation'] controlledtAe1: trigger-arg-path: stimulated >dobj controlled:Phosphorylationtle1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] controlled:Phosphorylationt interceding-token ngrams: , IGF2t\e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='igf2'] Gene_or_gene_producttPe1: trigger-arg-path: stimulated >dobj [lemma='phosphorylation'] PhosphorylationtKe1: trigger-arg-path: stimulated >nsubj [lemma='igf2'] Gene_or_gene_productt&interceding-token ngrams: not increaset-interceding-token ngrams: Akt phosphorylationt2e1: args2Role-mention-ngram: stimulated CONTROLLEDt1e1: trigger-arg-path: stimulated >dobj controlledtAe1: trigger-arg-path: stimulated >nsubj [lemma='igf2'] controllert=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulatedt$interceding-token ngrams: , IGF2 didtCe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj controllert&interceding-token ngrams: increase Aktt2e1: args2Role-mention-ngram: CONTROLLER stimulatedt6e1: trigger-arg-path: stimulated >dobj PhosphorylationtVe1: trigger-arg-path: stimulated >nsubj [lemma='igf2'] controller:Gene_or_gene_producttGe1: trigger-arg-path: stimulated >nsubj controller:Gene_or_gene_productt2interceding-token ngrams: Akt phosphorylation overt[e1: trigger-arg-path: stimulated:Positive_regulation >nsubj controller:Gene_or_gene_producttnsubj Gene_or_gene_productt(interceding-token ngrams: salirasib . BytXe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj controller:Gene_or_gene_productt3interceding-token ngrams: affected by pre-treatmentt(interceding-token ngrams: cells that wast[e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj Phosphorylationt.interceding-token ngrams: phosphorylation overtPe1: trigger-arg-path: stimulated:Positive_regulation >nsubj Gene_or_gene_producttKe1: trigger-arg-path: stimulated >dobj [lemma='phosphorylation'] controlledt"interceding-token ngrams: IGF2 didt\e1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='phosphorylation'] controlledt2e1: trigger-arg-path: stimulated >nsubj controllert6interceding-token ngrams: pre-treatment with salirasibt/e1: ents2Label-mention-ngram: stimulated SHAREDt*interceding-token ngrams: by pre-treatmenttVe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj controlledt?e1: ents2Label-mention-ngram: stimulated SHARED phosphorylationt6interceding-token ngrams: increase Akt phosphorylationt*interceding-token ngrams: not increase Aktt=e1: args2Role-mention-ngram: CONTROLLER stimulated CONTROLLEDt*interceding-token ngrams: Hep3B cells thattWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj controllertde1: trigger-arg-path: stimulated:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt[e1: trigger-arg-path: stimulated >dobj [lemma='phosphorylation'] controlled:Phosphorylationtje1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='igf2'] controller:Gene_or_gene_productt*interceding-token ngrams: did not increaset/interceding-token ngrams: by pre-treatment withtRe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlled:Phosphorylationtle1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj controller:Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj Phosphorylationt?interceding-tokens-full-span: in HepG2 and Hep3B cells that was not affected by pre-treatment with salirasib . By contrast , IGF2 did not increase Akt phosphorylation over controls in Huh7 cells but pre-treatment withtfe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj controlled:Phosphorylationtge1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='igf2'] controller:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='igf2'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='igf2'] controllert7interceding-token ngrams: phosphorylation over controlst&interceding-token ngrams: that was nottUe1: trigger-arg-path: stimulated:Positive_regulation >dobj controlled:PhosphorylationtBe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlledt%interceding-token ngrams: salirasib .tue1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt&interceding-token ngrams: IGF2 did nottFe1: trigger-arg-path: stimulated:Positive_regulation >nsubj controllertMe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj Gene_or_gene_producttDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulated SHAREDtEe1: trigger-arg-path: stimulated:Positive_regulation >dobj controlledtoe1: trigger-arg-path: stimulated:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationt_e1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='igf2'] Gene_or_gene_productt*interceding-token ngrams: with salirasib .tfe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='igf2'] controllertpe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='phosphorylation'] controlledt{e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='igf2'] controller:Gene_or_gene_productt.e1: args2Role-mention-ngram: impair CONTROLLEDt.e1: trigger-arg-path: impair >nsubj controllertRe1: trigger-arg-path: impair >dobj [lemma='activity'] >nn [lemma='p53'] controlledt_e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledtte1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttpe1: trigger-arg-path: impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj controllertde1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj [lemma='hif-1'] controllert"interceding-token ngrams: kinase-2tie1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt#interceding-token ngrams: HIPK2 ) .tSe1: trigger-arg-path: impair >nsubj [lemma='hif-1'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: also impairtCe1: trigger-arg-path: impair >nsubj controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: also impair CONTROLLEDtxe1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledt4interceding-token ngrams: through the downregulationtie1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj controller:Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj >nn controlled:Gene_or_gene_productt6interceding-token ngrams: tumor suppressor homeodomaint+interceding-token ngrams: downregulation oft,interceding-token ngrams: protein kinase-2 (tPe1: trigger-arg-path: lemmatizedTrigger=impair >nsubj [lemma='hif-1'] controllert$interceding-token ngrams: kinase-2 (tHe1: trigger-arg-path: impair >nsubj [lemma='hif-1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: also impair SHAREDtBe1: trigger-arg-path: impair:Negative_activation >nsubj controllertZe1: trigger-arg-path: lemmatizedTrigger=impair >nsubj [lemma='hif-1'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=impair >nsubj controller:Gene_or_gene_producttLe1: trigger-arg-path: impair:Negative_activation >nsubj Gene_or_gene_productt,interceding-token ngrams: the downregulationtne1: trigger-arg-path: lemmatizedTrigger=impair >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_productt#interceding-token ngrams: the tumortne1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj [lemma='hif-1'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=impair >nsubj Gene_or_gene_productt1e1: trigger-arg-path: impair >dobj >nn controlledt0interceding-token ngrams: suppressor homeodomaintge1: trigger-arg-path: impair:Negative_activation >nsubj [lemma='hif-1'] controller:Gene_or_gene_productt+e1: ents2Label-mention-ngram: impair SHAREDtdobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttWe1: trigger-arg-path: impair:Negative_activation >nsubj controller:Gene_or_gene_productt*interceding-token ngrams: protein kinase-2t^e1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=impair >dobj [lemma='activity'] >nn [lemma='p53'] controlledt>e1: trigger-arg-path: impair >nsubj [lemma='hif-1'] controllertKe1: trigger-arg-path: Negative_activation >nsubj [lemma='hif-1'] controllertMe1: trigger-arg-path: lemmatizedTrigger=impair >dobj >nn Gene_or_gene_productt,interceding-token ngrams: activity , throught/interceding-token ngrams: the downregulation oft{e1: trigger-arg-path: impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt\e1: trigger-arg-path: impair >dobj [lemma='activity'] >nn [lemma='p53'] Gene_or_gene_producttFe1: trigger-arg-path: impair >dobj >nn controlled:Gene_or_gene_producttZe1: trigger-arg-path: impair:Negative_activation >dobj >nn controlled:Gene_or_gene_productt,e1: args2Role-mention-ngram: can also impairt\e1: trigger-arg-path: impair:Negative_activation >nsubj [lemma='hif-1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj >nn Gene_or_gene_productt6interceding-token ngrams: interacting protein kinase-2tRe1: trigger-arg-path: impair:Negative_activation >nsubj [lemma='hif-1'] controllertye1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >nsubj [lemma='hif-1'] controller:Gene_or_gene_producttCe1: trigger-arg-path: lemmatizedTrigger=impair >dobj >nn controlledtOe1: trigger-arg-path: impair:Negative_activation >dobj >nn Gene_or_gene_productt9interceding-token ngrams: homeodomain interacting proteint1interceding-token ngrams: homeodomain interactingt;e1: trigger-arg-path: impair >dobj >nn Gene_or_gene_productt`e1: trigger-arg-path: Negative_activation >nsubj [lemma='hif-1'] controller:Gene_or_gene_productt?interceding-tokens-full-span: activity , through the downregulation of the tumor suppressor homeodomain interacting protein kinase-2 ( HIPK2 ) .tWe1: trigger-arg-path: lemmatizedTrigger=impair:Negative_activation >dobj >nn controlledt/interceding-token ngrams: downregulation of thet@e1: trigger-arg-path: lemmatizedTrigger=impair >nsubj controllert)e1: ents2Label-mention-ngram: also impairt(interceding-token ngrams: downregulationtge1: trigger-arg-path: impair >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_productt.interceding-token ngrams: the tumor suppressort%interceding-token ngrams: homeodomaintfe1: trigger-arg-path: impair:Negative_activation >dobj [lemma='activity'] >nn [lemma='p53'] controlledtXe1: trigger-arg-path: lemmatizedTrigger=impair >dobj >nn controlled:Gene_or_gene_productt&interceding-token ngrams: of the tumortye1: trigger-arg-path: lemmatizedTrigger=impair >dobj [lemma='activity'] >nn [lemma='p53'] controlled:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=impair >nsubj [lemma='hif-1'] controller:Gene_or_gene_productt*interceding-token ngrams: kinase-2 ( HIPK2t-e1: ents2Label-mention-ngram: can also impairtUe1: trigger-arg-path: Negative_activation >nsubj [lemma='hif-1'] Gene_or_gene_productt8e1: trigger-arg-path: impair >nsubj Gene_or_gene_producttSe1: trigger-arg-path: induces >nsubj [lemma='hif1'] controller:Gene_or_gene_producttDinterceding-token ngrams: different post-translational modificationst:interceding-token ngrams: post-translational modificationstde2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='klhl20'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hif1'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='transcription'] BioProcesst_e1: trigger-arg-path: Positive_activation >nsubj [lemma='hif1'] controller:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='klhl20'] theme:Gene_or_gene_producttZe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='transcription'] controlledt=interceding-token ngrams: post-translational modifications oft"interceding-token ngrams: PML maket#interceding-token ngrams: of KLHL20tNe2: trigger-arg-path: Binding >prep_with [lemma='klhl20'] Gene_or_gene_producttge1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='hif1'] controller:Gene_or_gene_productt>e1: trigger-arg-path: induces >nsubj [lemma='hif1'] controllert$interceding-token ngrams: scenario ,tve1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='transcription'] controlled:BioProcesst#interceding-token ngrams: PML-NBs .tTe2: trigger-arg-path: Binding >prep_with [lemma='klhl20'] theme:Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='hif1'] controller:Gene_or_gene_producttFe1: trigger-arg-path: induces >dobj [lemma='transcription'] controlledtRe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='hif1'] controllert"CSSPATH: ROOT  ++ ROOT >acomp >deptJe1: trigger-arg-path: Positive_activation >nsubj [lemma='hif1'] controllertXe2: trigger-arg-path: interaction >prep_with [lemma='klhl20'] theme:Gene_or_gene_producttRe2: trigger-arg-path: interaction >prep_with [lemma='klhl20'] Gene_or_gene_productt)interceding-token ngrams: , two differentt+interceding-token ngrams: PML make possibletOe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hif1'] controllert3interceding-token ngrams: accumulation into PML-NBstHe1: trigger-arg-path: induces >nsubj [lemma='hif1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='klhl20'] themet/interceding-token ngrams: its accumulation intot interceding-token ngrams: KLHL20t&interceding-token ngrams: PML-NBs . Int(interceding-token ngrams: scenario , twot"interceding-token ngrams: KLHL20 ,tke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='transcription'] BioProcesst+interceding-token ngrams: accumulation intot%interceding-token ngrams: of PML maketUe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='klhl20'] themetWe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='transcription'] controlledtce1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='hif1'] controllertCe2: trigger-arg-path: interaction >prep_with [lemma='klhl20'] themetbe1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='transcription'] controlled:BioProcesst*interceding-token ngrams: modifications oft'interceding-token ngrams: make possibletee1: trigger-arg-path: induces:Positive_activation >dobj [lemma='transcription'] controlled:BioProcesst*interceding-token ngrams: In this scenariot`e2: trigger-arg-path: interaction:Binding >prep_with [lemma='klhl20'] theme:Gene_or_gene_productt,interceding-token ngrams: post-translationalt?e2: trigger-arg-path: Binding >prep_with [lemma='klhl20'] themet\e1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='hif1'] Gene_or_gene_productt.interceding-token ngrams: modifications of PMLtje2: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='klhl20'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='hif1'] controller:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='klhl20'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENERIC_ENTITY interaction witht(interceding-token ngrams: into PML-NBs .tZe1: trigger-arg-path: induces:Positive_activation >dobj [lemma='transcription'] BioProcesst'interceding-token ngrams: this scenariot-interceding-token ngrams: KLHL20 , increasingtinterceding-token ngrams: , twotinterceding-token ngrams: intot&interceding-token ngrams: into PML-NBstme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='hif1'] Gene_or_gene_productt)interceding-token ngrams: this scenario ,tFe1: trigger-arg-path: induces >dobj [lemma='transcription'] BioProcesst>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT induces thet:interceding-token ngrams: two different post-translationaltinterceding-token ngrams: maket&interceding-token ngrams: , increasingt%interceding-token ngrams: of KLHL20 ,t(interceding-token ngrams: increasing itst*interceding-token ngrams: its accumulationtQe1: trigger-arg-path: induces >dobj [lemma='transcription'] controlled:BioProcesst?interceding-tokens-full-span: of KLHL20 , increasing its accumulation into PML-NBs . In this scenario , two different post-translational modifications of PML make possiblet,e1: ents2Label-mention-ngram: the BIOPROCESSt8e2: ents2Label-mention-ngram: GENERIC_ENTITY interactiont5interceding-token ngrams: increasing its accumulationt*interceding-token ngrams: , increasing itst4e1: ents2Label-mention-ngram: induces the BIOPROCESStKe2: trigger-arg-path: interaction:Binding >prep_with [lemma='klhl20'] themetke1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='transcription'] controlledtZe2: trigger-arg-path: interaction:Binding >prep_with [lemma='klhl20'] Gene_or_gene_productt'interceding-token ngrams: two differenttTe1: trigger-arg-path: Positive_activation >nsubj [lemma='hif1'] Gene_or_gene_productt6interceding-token ngrams: different post-translationalt-e2: ents2Label-mention-ngram: synthase kinaset(e2: ents2Label-mention-ngram: , feedbacktWe1: trigger-arg-path: Negative_activation dobj controlled:Gene_or_gene_productt-e1: ents2Label-mention-ngram: SHP2 negativelyt"interceding-token ngrams: as ERK ,t&e2: args2Role-mention-ngram: or mTOR (t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos [lemma='gsk3'] controllert|e1: trigger-arg-path: negatively regulates nsubj [lemma='shp2'] >nn [lemma='phosphatase'] Familytee2: trigger-arg-path: phosphorylate:Positive_regulation appos controller:Gene_or_gene_producttXe1: trigger-arg-path: negatively regulates:Negative_activation nsubj >nn Familyt&e2: ents2Label-mention-ngram: GAB1 andt,e2: ents2Label-mention-ngram: , feedback andt+e2: args2Role-mention-ngram: , feedback andt?e1: trigger-arg-path: negatively regulates:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos [lemma='gsk3'] controller:Gene_or_gene_producttappos controllert-interceding-token ngrams: is partly explainedthe1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj controlledt"e2: args2Role-mention-ngram: ( thet#e2: args2Role-mention-ngram: mTOR (t&e2: ents2Label-mention-ngram: feedbacktXe1: trigger-arg-path: negatively regulates dobj controlled:Gene_or_gene_productt0e2: args2Role-mention-ngram: mammalian target oftLe1: trigger-arg-path: Negative_activation dobj Gene_or_gene_productt(e2: ents2Label-mention-ngram: mTOR ( thet%interceding-token ngrams: of EGFR andt#e2: ents2Label-mention-ngram: ( thet8e2: ents2Label-mention-ngram: feedback and phosphorylatet$interceding-token ngrams: Downstreamt'e2: args2Role-mention-ngram: , feedbacktMe1: trigger-arg-path: negatively regulates dobj Gene_or_gene_producttinterceding-token ngrams: GAB1t(interceding-token ngrams: influences ERKtDe1: trigger-arg-path: negatively regulates nsubj >nn Familyt interceding-token ngrams: partlyt0e2: ents2Label-mention-ngram: phosphorylate GAB1t=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( glycogentae1: trigger-arg-path: negatively regulates:Negative_activation dobj Gene_or_gene_productt,e2: args2Role-mention-ngram: synthase kinaset*e2: ents2Label-mention-ngram: of rapamycint'e2: args2Role-mention-ngram: mTOR ( thet*e2: ents2Label-mention-ngram: feedback andt&e2: args2Role-mention-ngram: ) or mTORt.e2: args2Role-mention-ngram: synthase kinase 3t!e2: ents2Label-mention-ngram: 3 )t?e1: trigger-arg-path: negatively regulates:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controller:Familyt\e2: trigger-arg-path: phosphorylate appos [lemma='gsk3'] controllert`e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj >nn controller:Familyt"e1: ents2Label-mention-ngram: SHP2t'e2: ents2Label-mention-ngram: ) or mTORtXe2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos Gene_or_gene_productt,e1: args2Role-mention-ngram: CONTROLLER SHP2t+interceding-token ngrams: in RasGAP bindingt4e2: args2Role-mention-ngram: feedback and CONTROLLEDtce1: trigger-arg-path: negatively regulates:Negative_activation nsubj >nn controller:FamilytZe2: trigger-arg-path: phosphorylate:Positive_regulation appos Gene_or_gene_producttye1: trigger-arg-path: negatively regulates dobj [lemma='IRS'] controlled:Gene_or_gene_productt!e2: args2Role-mention-ngram: ) ort4e1: ents2Label-mention-ngram: FAMILY SHP2 negativelyt#e2: args2Role-mention-ngram: 3 ) ort+e2: args2Role-mention-ngram: of rapamycin )t1interceding-token ngrams: specific sites involvedtOe1: trigger-arg-path: negatively regulates nsubj >nn controller:Familyt+interceding-token ngrams: and AKT signalingt,e2: ents2Label-mention-ngram: of rapamycin )t}e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj controlled:Gene_or_gene_productt)interceding-token ngrams: which is partlytle2: trigger-arg-path: Positive_regulation appos [lemma='gsk3'] Gene_or_gene_producttxe1: trigger-arg-path: Negative_activation dobj [lemma='IRS'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj >nn controllert#CSSPATH: ROOT >advcl ++ ROOT >appost.interceding-token ngrams: binding . Downstreamt'e2: ents2Label-mention-ngram: rapamycint&e2: args2Role-mention-ngram: rapamycintPe2: trigger-arg-path: phosphorylate:Positive_regulation appos controllert1e2: ents2Label-mention-ngram: ( glycogen synthaset interceding-token ngrams: and IRt(interceding-token ngrams: RasGAP bindingt(interceding-token ngrams: specific sitest^e1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj Gene_or_gene_productt?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='IRS'] Gene_or_gene_producttfe2: trigger-arg-path: phosphorylate appos [lemma='gsk3'] Gene_or_gene_productt1interceding-token ngrams: by dephosphorylation oftre1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj Gene_or_gene_productt,interceding-token ngrams: Downstream targetst.interceding-token ngrams: by dephosphorylationt$interceding-token ngrams: targets oft'e2: args2Role-mention-ngram: ( glycogent?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj [lemma='IRS'] controlled:Gene_or_gene_productt e2: args2Role-mention-ngram: 3 )te1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj [lemma='IRS'] Gene_or_gene_productt*interceding-token ngrams: partly explainedt'interceding-token ngrams: it positivelyt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='IRS'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controller:Familytce1: trigger-arg-path: Negative_activation dobj [lemma='IRS'] controlledtne2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos [lemma='gsk3'] controllert/e2: ents2Label-mention-ngram: synthase kinase 3te1: trigger-arg-path: Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controllertme1: trigger-arg-path: Negative_activation dobj [lemma='IRS'] Gene_or_gene_producttNe1: trigger-arg-path: Negative_activation nsubj >nn controller:Familytle1: trigger-arg-path: negatively regulates:Negative_activation dobj controlled:Gene_or_gene_productt1e2: ents2Label-mention-ngram: target of rapamycint7e1: ents2Label-mention-ngram: SHP2 negatively regulatestNe2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos controllert!e2: args2Role-mention-ngram: mTORt{e1: trigger-arg-path: Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] FamilytCe1: trigger-arg-path: negatively regulates dobj controlledt)e2: args2Role-mention-ngram: of rapamycint)e2: ents2Label-mention-ngram: rapamycin )tFe2: trigger-arg-path: phosphorylate appos Gene_or_gene_productt8interceding-token ngrams: explained by dephosphorylationt"interceding-token ngrams: and IR ,tinterceding-token ngrams: IR ,t?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='shp2'] >nn [lemma='phosphatase'] Familyt(e2: ents2Label-mention-ngram: ( glycogent.e2: ents2Label-mention-ngram: mammalian targett*interceding-token ngrams: RasGAP binding .t&interceding-token ngrams: explained byt&interceding-token ngrams: and PI3K andt"e2: ents2Label-mention-ngram: ) ort.interceding-token ngrams: dephosphorylation oft0e2: args2Role-mention-ngram: target of rapamycintie1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj >nn Familyt interceding-token ngrams: as ERKtbe2: trigger-arg-path: Positive_regulation appos [lemma='gsk3'] controllert?e1: trigger-arg-path: Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controller:Familyt6e2: ents2Label-mention-ngram: glycogen synthase kinaset?e1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='IRS'] controlled:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos [lemma='gsk3'] Gene_or_gene_productt?interceding-tokens-full-span: , GAB1 and PI3K and AKT signaling , it positively influences ERK activity , which is partly explained by dephosphorylation of the specific sites involved in RasGAP binding . Downstream targets of EGFR and IR , such as ERK ,t%interceding-token ngrams: such as ERKt.e2: args2Role-mention-ngram: glycogen synthaset?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controllert\e1: trigger-arg-path: negatively regulates:Negative_activation nsubj >nn controllert$interceding-token ngrams: , GAB1 andtWe2: trigger-arg-path: Positive_regulation appos controller:Gene_or_gene_productt)e2: args2Role-mention-ngram: feedback andtwe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos controller:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj >nn Familyt*e2: ents2Label-mention-ngram: ) , feedbackt%e2: ents2Label-mention-ngram: or mTORt0e2: args2Role-mention-ngram: ( glycogen synthasetCe1: trigger-arg-path: Negative_activation nsubj >nn Familyt1e2: args2Role-mention-ngram: the mammalian targett)interceding-token ngrams: of the specifict%e2: args2Role-mention-ngram: glycogentie1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj controlled:Gene_or_gene_productt"interceding-token ngrams: and PI3Kt(interceding-token ngrams: ERK activity ,t(interceding-token ngrams: sites involvedtGe1: trigger-arg-path: Negative_activation nsubj >nn controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos [lemma='gsk3'] controller:Gene_or_gene_productt.interceding-token ngrams: . Downstream targetstne1: trigger-arg-path: negatively regulates dobj [lemma='IRS'] Gene_or_gene_productt-interceding-token ngrams: partly explained byt7e1: args2Role-mention-ngram: CONTROLLER SHP2 negativelyt2interceding-token ngrams: it positively influencest(e2: args2Role-mention-ngram: rapamycin )t%interceding-token ngrams: EGFR and IRt/interceding-token ngrams: Downstream targets oft-e2: args2Role-mention-ngram: mammalian targettme1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj >nn controllert,e1: args2Role-mention-ngram: SHP2 negativelytqe2: trigger-arg-path: phosphorylate appos [lemma='gsk3'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=phosphorylate appos controller:Gene_or_gene_productt)interceding-token ngrams: , it positivelyt*interceding-token ngrams: activity , whicht)interceding-token ngrams: AKT signaling ,t?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controllert?e1: trigger-arg-path: negatively regulates nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controllert#interceding-token ngrams: in RasGAPtTe1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj controlledt"interceding-token ngrams: GAB1 andtwe2: trigger-arg-path: Positive_regulation appos [lemma='gsk3'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: FAMILY SHP2tbe2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos controllert interceding-token ngrams: RasGAPt!e1: args2Role-mention-ngram: SHP2t%e2: args2Role-mention-ngram: synthaset&e2: ents2Label-mention-ngram: glycogent/e2: ents2Label-mention-ngram: and phosphorylatet3interceding-token ngrams: positively influences ERKtHe1: trigger-arg-path: negatively regulates nsubj >nn controllert,interceding-token ngrams: involved in RasGAPt#interceding-token ngrams: explainedt$e2: ents2Label-mention-ngram: mTOR (t$e2: args2Role-mention-ngram: or mTORt*e2: args2Role-mention-ngram: rapamycin ) ,t'interceding-token ngrams: GAB1 and PI3Kt-e2: ents2Label-mention-ngram: ( the mammaliantBe1: trigger-arg-path: Negative_activation dobj controlledt#interceding-token ngrams: IR , sucht)interceding-token ngrams: targets of EGFRt1interceding-token ngrams: influences ERK activityt1e2: ents2Label-mention-ngram: mammalian target oft5e2: args2Role-mention-ngram: glycogen synthase kinaset2e2: args2Role-mention-ngram: CONTROLLER ( glycogent?e2: trigger-arg-path: phosphorylate:Positive_regulation appos [lemma='gsk3'] controller:Gene_or_gene_producttLe2: trigger-arg-path: Positive_regulation appos Gene_or_gene_productt4e2: ents2Label-mention-ngram: phosphorylate GAB1 andt-e2: ents2Label-mention-ngram: GAB1 and SHAREDt(e2: ents2Label-mention-ngram: kinase 3 )t"e2: ents2Label-mention-ngram: mTORt2e2: ents2Label-mention-ngram: the mammalian targett)e2: args2Role-mention-ngram: ) , feedbacktQe2: trigger-arg-path: phosphorylate appos controller:Gene_or_gene_productt4e2: ents2Label-mention-ngram: and phosphorylate GAB1t6e1: args2Role-mention-ngram: SHP2 negatively regulatest'e2: ents2Label-mention-ngram: or mTOR (t?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='IRS'] controlled:Gene_or_gene_producttWe1: trigger-arg-path: negatively regulates:Negative_activation dobj controlledtpe2: trigger-arg-path: phosphorylate:Positive_regulation appos [lemma='gsk3'] controllertle2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos Gene_or_gene_producttde1: trigger-arg-path: negatively regulates dobj [lemma='IRS'] controlledt,e2: args2Role-mention-ngram: ( the mammaliant+e2: ents2Label-mention-ngram: and SHARED ont?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] Familytue1: trigger-arg-path: lemmatizedTrigger=negatively regulate dobj [lemma='IRS'] controlledtze2: trigger-arg-path: phosphorylate:Positive_regulation appos [lemma='gsk3'] Gene_or_gene_productt%e2: args2Role-mention-ngram: feedbackt?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controller:Familyt?e1: trigger-arg-path: negatively regulates nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controller:Familyt(interceding-token ngrams: signaling , itt'e2: args2Role-mention-ngram: kinase 3 )t2interceding-token ngrams: dephosphorylation of thet?e1: trigger-arg-path: negatively regulates:Negative_activation nsubj [lemma='shp2'] >nn [lemma='phosphatase'] controllert#interceding-token ngrams: binding .t/e2: ents2Label-mention-ngram: glycogen synthaset$interceding-token ngrams: influencest&e2: ents2Label-mention-ngram: synthaset&interceding-token ngrams: . Downstreamt"interceding-token ngrams: EGFR andt/interceding-token ngrams: positively influencest$e2: ents2Label-mention-ngram: 3 ) ort+e2: ents2Label-mention-ngram: rapamycin ) ,tBe2: trigger-arg-path: Positive_regulation appos controllertte1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation nsubj >nn controller:Familyt+interceding-token ngrams: dephosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation appos [lemma='gsk3'] Gene_or_gene_productt+interceding-token ngrams: sites involved int?e1: trigger-arg-path: lemmatizedTrigger=negatively regulate:Negative_activation dobj [lemma='IRS'] Gene_or_gene_productt interceding-token ngrams: , GAB1txe1: trigger-arg-path: negatively regulates:Negative_activation dobj [lemma='IRS'] controlledt'interceding-token ngrams: AKT signalingt,interceding-token ngrams: the specific sitest#interceding-token ngrams: is partlyt4e2: ents2Label-mention-ngram: SHARED binding proteint.e1: trigger-arg-path: binding nn [lemma='gtp'] themetOe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gtp'] Gene_or_gene_productt=e1: trigger-arg-path: binding:Binding nn [lemma='gtp'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gtp'] theme:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gtp'] themet;e1: trigger-arg-path: binding nn [lemma='gtp'] theme:Gene_or_gene_productt[e1: trigger-arg-path: binding nn [lemma='gtp'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binding:Binding nn [lemma='gtp'] themet(e1: trigger-arg-path: Binding nn [lemma='gtp'] theme:Gene_or_gene_producttFe1: trigger-arg-path: binding nn [lemma='gtp'] themetAe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gtp'] theme:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gtp'] Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gtp'] themetCe1: trigger-arg-path: binding:Binding nn [lemma='gtp'] theme:Gene_or_gene_producttFe1: trigger-arg-path: Binding nn [lemma='gtp'] themet'e1: trigger-arg-path: Binding nn [lemma='gtp'] themet.e2: trigger-arg-path: binding nn [lemma='gtp'] Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gtp'] Gene_or_gene_producttUe1: trigger-arg-path: Binding nn [lemma='gtp'] Gene_or_gene_producttNe2: trigger-arg-path: binding:Binding nn [lemma='gtp'] themet0e2: trigger-arg-path: binding:Binding nn [lemma='gtp'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: protein SHAREDt4e1: trigger-arg-path: Binding nn [lemma='gtp'] Gene_or_gene_producttnn [lemma='gtp'] theme:Gene_or_gene_productt.e2: trigger-arg-path: Binding nn [lemma='gtp'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='gtp'] themetUe2: trigger-arg-path: binding nn [lemma='gtp'] Gene_or_gene_productt[e2: trigger-arg-path: Binding nn [lemma='gtp'] theme:Gene_or_gene_producttFe2: trigger-arg-path: Binding nn [lemma='gtp'] themet2e1: args2Role-mention-ngram: THEME binding proteint[e1: trigger-arg-path: Binding nn [lemma='gtp'] theme:Gene_or_gene_productt9e1: trigger-arg-path: lemmatizedTrigger=binding nn [lemma='gtp'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding nn [lemma='binding']tNe1: trigger-arg-path: lemmatizedTrigger=binding:Binding nsubj [lemma='protein'] Gene_or_gene_productt"interceding-token ngrams: VPS4A totinterceding-token ngrams: CHMP6tKe2: trigger-arg-path: Binding >nsubj [lemma='protein'] Gene_or_gene_productt&interceding-token ngrams: Ras proteinst&e2: ents2Label-mention-ngram: may bindt=e2: trigger-arg-path: bind:Binding >dobj theme:Generic_entitytVe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='they'] theme:Generic_entityt)interceding-token ngrams: CHMP6 and VPS4At*interceding-token ngrams: be ubiquitylatedtSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] themet/interceding-token ngrams: ubiquitylated and GTPthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='protein'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: may bind THEMEtQe2: trigger-arg-path: Binding >nsubj [lemma='protein'] theme:Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj theme:Generic_entityt&interceding-token ngrams: latter to betHe2: trigger-arg-path: bind >nsubj [lemma='protein'] Gene_or_gene_productt)interceding-token ngrams: to Ras proteinst8e2: trigger-arg-path: Binding >dobj theme:Generic_entitytAe2: trigger-arg-path: lemmatizedTrigger=bind >dobj Generic_entitytinterceding-token ngrams: N-t interceding-token ngrams: lattertnsubj [lemma='protein'] themet-interceding-token ngrams: requires the lattert/interceding-token ngrams: Ras proteins requirestGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj theme:Generic_entitytAe2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] themet&interceding-token ngrams: and VPS4A tot`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] theme:Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] Gene_or_gene_productt9e2: trigger-arg-path: bind >nsubj [lemma='protein'] themet'interceding-token ngrams: the latter tot(interceding-token ngrams: bound and thatt5e2: trigger-arg-path: bind >dobj theme:Generic_entitytXe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='they'] Generic_entitytNe2: trigger-arg-path: bind >nsubj [lemma='protein'] theme:Gene_or_gene_producttFe2: trigger-arg-path: bind:Binding >dobj [lemma='they'] Generic_entityt=e2: trigger-arg-path: bind:Binding >dobj [lemma='they'] themetOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='they'] themet'interceding-token ngrams: ubiquitylatedt'interceding-token ngrams: GTP bound andt+interceding-token ngrams: proteins requirest6e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT maytVe2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] theme:Gene_or_gene_productt8e2: trigger-arg-path: Binding >dobj [lemma='they'] themet-e2: ents2Label-mention-ngram: may bind SHAREDt interceding-token ngrams: N- andt#interceding-token ngrams: CHMP6 andtAe2: trigger-arg-path: Binding >dobj [lemma='they'] Generic_entitytGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='they'] themet>e2: trigger-arg-path: bind >dobj [lemma='they'] Generic_entityt.interceding-token ngrams: be ubiquitylated andt%interceding-token ngrams: that N- andt"interceding-token ngrams: of CHMP6t2e2: trigger-arg-path: Binding >dobj Generic_entityt5e2: trigger-arg-path: bind >dobj [lemma='they'] themetDe2: trigger-arg-path: bind >dobj [lemma='they'] theme:Generic_entityt'interceding-token ngrams: and GTP boundt&interceding-token ngrams: requires thetLe2: trigger-arg-path: bind:Binding >dobj [lemma='they'] theme:Generic_entityt#interceding-token ngrams: and VPS4AtPe2: trigger-arg-path: bind:Binding >nsubj [lemma='protein'] Gene_or_gene_productt+interceding-token ngrams: efficient bindingt/e2: trigger-arg-path: bind >dobj Generic_entityt+interceding-token ngrams: ubiquitylated andt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT may bindt/interceding-token ngrams: proteins requires thetIe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj Generic_entityt#interceding-token ngrams: bound andt+e2: args2Role-mention-ngram: THEME may bindt!interceding-token ngrams: that N-t&interceding-token ngrams: VPS4A to Rast#interceding-token ngrams: latter tot%e2: args2Role-mention-ngram: may bindt%interceding-token ngrams: and that N-tKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='protein'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='they'] theme:Generic_entityt.interceding-token ngrams: efficient binding oft!interceding-token ngrams: and GTPtGe2: trigger-arg-path: Binding >dobj [lemma='they'] theme:Generic_entityt7e2: trigger-arg-path: bind:Binding >dobj Generic_entitytPe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='they'] Generic_entityt*interceding-token ngrams: binding of CHMP6t0interceding-token ngrams: that efficient bindingt&interceding-token ngrams: of CHMP6 andt?interceding-tokens-full-span: or VPS4A . These data suggest that efficient binding of CHMP6 and VPS4A to Ras proteins requires the latter to be ubiquitylated and GTP bound and that N- andt-interceding-token ngrams: to be ubiquitylatedt7e2: ents2Label-mention-ngram: CHK1 phosphorylate SHAREDt-e1: ents2Label-mention-ngram: SHARED at Ser20tje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controllertbe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_producttYe1: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] controller:Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_productt,e1: args2Role-mention-ngram: CHK1 CONTROLLEDt!e1: args2Role-mention-ngram: CHK1t&e2: ents2Label-mention-ngram: at Ser20tYe2: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] controller:Gene_or_gene_productt&e1: ents2Label-mention-ngram: at Ser20te2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_productt0e2: args2Role-mention-ngram: CONTROLLER and CHK1t7e1: ents2Label-mention-ngram: CHK1 phosphorylate SHAREDt!e2: args2Role-mention-ngram: CHK1t0e2: args2Role-mention-ngram: and CHK1 CONTROLLEDtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] controllertke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: CHK1 CONTROLLEDt#e1: ents2Label-mention-ngram: Ser20tDe1: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] controllert4e2: ents2Label-mention-ngram: and CHK1 phosphorylatette2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: CHK1 phosphorylatet`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] Gene_or_gene_producttme2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_producttDe2: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] controllertke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] controller:Gene_or_gene_producttme1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_producttNe1: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] Gene_or_gene_productt%e2: args2Role-mention-ngram: and CHK1t-e2: ents2Label-mention-ngram: SHARED and CHK1tJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] controllert#e2: ents2Label-mention-ngram: Ser20tte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_producttXe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controllertXe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controllert-e2: ents2Label-mention-ngram: SHARED at Ser20t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='chk2'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER and CHK1t&e2: ents2Label-mention-ngram: and CHK1tNe2: trigger-arg-path: phosphorylate >nsubj [lemma='chk2'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] controllert0e2: ents2Label-mention-ngram: CHK1 phosphorylatet-e1: ents2Label-mention-ngram: SHARED and CHK1t%e1: args2Role-mention-ngram: and CHK1tVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] controllertbe2: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='chk2'] Gene_or_gene_productt&e1: ents2Label-mention-ngram: and CHK1t`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='chk2'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: and CHK1 phosphorylatetje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='chk2'] controllert0e1: args2Role-mention-ngram: and CHK1 CONTROLLEDt-e2: ents2Label-mention-ngram: granule cells (tinterceding-token ngrams: ASK1-t?e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controller:Gene_or_gene_productt!interceding-token ngrams: death .t)e1: ents2Label-mention-ngram: of ASK1 andtdobj controlled:Phosphorylationt-e2: args2Role-mention-ngram: ) also decreasest[e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] controlledt?interceding-tokens-full-span: that belong to the MAPKKK upstream activation of JNK , and the final effect is the decrease of ASK1- and MLK3 mediated cell death . Conversely , the inhibition oft%e2: ents2Label-mention-ngram: cells (t#interceding-token ngrams: ASK1- andt,interceding-token ngrams: MLK3 mediated cellt'e2: args2Role-mention-ngram: cerebellart)e2: args2Role-mention-ngram: cells ( CGCstle2: trigger-arg-path: decreases >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] Gene_or_gene_producttinterceding-token ngrams: finalt-e1: ents2Label-mention-ngram: the activity oft?e2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controller:Gene_or_gene_producttwe1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='akt'] Gene_or_gene_productt0interceding-token ngrams: upstream activation oftYe1: trigger-arg-path: phosphorylate nsubj [lemma='akt'] controllert,e2: args2Role-mention-ngram: granule cells (t?e2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controllert'interceding-token ngrams: MLK3 mediatedt$e2: ents2Label-mention-ngram: CGCs )tCSSPATH: ROOT >xcomp ++ ROOT t-interceding-token ngrams: mediated cell deatht'interceding-token ngrams: and the finalt)interceding-token ngrams: final effect ist*interceding-token ngrams: , the inhibitiont(e2: ents2Label-mention-ngram: cerebellart'interceding-token ngrams: belong to thetne2: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtAe2: ents2Label-mention-ngram: also decreases GENE_OR_GENE_PRODUCTt%interceding-token ngrams: decrease oft6e2: args2Role-mention-ngram: also decreases CONTROLLEDtte1: trigger-arg-path: Positive_regulation nsubj [lemma='akt'] controller:Gene_or_gene_producttve2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] Gene_or_gene_productt&interceding-token ngrams: final effectt-interceding-token ngrams: upstream activationt`e2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] Phosphorylationt$e2: args2Role-mention-ngram: cells (t?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controller:Gene_or_gene_producttNe2: trigger-arg-path: decreases:Positive_regulation >nsubj >prep_of controllert*e1: ents2Label-mention-ngram: the activitytJe2: trigger-arg-path: decreases >dobj [lemma='phosphorylation'] controlledtUe2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj controlledt9e2: ents2Label-mention-ngram: cultured cerebellar granuletOe2: trigger-arg-path: decreases >dobj [lemma='phosphorylation'] Phosphorylationt2e1: ents2Label-mention-ngram: inhibit the activityt?e2: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED is ablet+interceding-token ngrams: decrease of ASK1-t$e2: ents2Label-mention-ngram: ( CGCst"interceding-token ngrams: of ASK1-tXe2: trigger-arg-path: decreases:Positive_regulation >nsubj >prep_of Gene_or_gene_productt"interceding-token ngrams: and MLK3tinterceding-token ngrams: MLK3tce2: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt,e2: ents2Label-mention-ngram: also decreasestinterceding-token ngrams: JNK ,t?e2: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controller:Gene_or_gene_productt*interceding-token ngrams: the final effectt_e2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of controllert(interceding-token ngrams: that belong tot6e2: ents2Label-mention-ngram: cerebellar granule cellst interceding-token ngrams: of JNKt)e2: ents2Label-mention-ngram: CGCs ) alsot)e2: ents2Label-mention-ngram: in culturedt3e2: args2Role-mention-ngram: CONTROLLER in culturedt#e2: args2Role-mention-ngram: CGCs )tee2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj controlled:Phosphorylationt+e2: args2Role-mention-ngram: also decreasestwe2: trigger-arg-path: decreases >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controller:Gene_or_gene_productt%e2: ents2Label-mention-ngram: granulet1e2: ents2Label-mention-ngram: cultured cerebellart.e1: ents2Label-mention-ngram: activity of ASK1t&interceding-token ngrams: cell death .tFe2: trigger-arg-path: lemmatizedTrigger=decrease >dobj Phosphorylationt/e1: args2Role-mention-ngram: CONTROLLER is ablet4e2: ents2Label-mention-ngram: in cultured cerebellart'interceding-token ngrams: to the MAPKKKt%e2: args2Role-mention-ngram: ( CGCs )t^e2: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] controlledte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='akt'] controllertZe2: trigger-arg-path: decreases >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='akt'] controller:Gene_or_gene_productt!e2: args2Role-mention-ngram: CGCst$e2: ents2Label-mention-ngram: ) alsot_e1: trigger-arg-path: Positive_regulation nsubj [lemma='akt'] controllert&interceding-token ngrams: the decreaset)interceding-token ngrams: is the decreasetOe2: trigger-arg-path: decreases >nsubj >prep_of controller:Gene_or_gene_producttve2: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controllertue1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='akt'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='akt'] controller:Gene_or_gene_productt+interceding-token ngrams: and MLK3 mediatedt#interceding-token ngrams: the finaltTe2: trigger-arg-path: decreases:Positive_regulation >dobj controlled:Phosphorylationt)interceding-token ngrams: MAPKKK upstreamt%e2: args2Role-mention-ngram: culturedt5e2: args2Role-mention-ngram: cerebellar granule cellst$e2: args2Role-mention-ngram: granulet0e2: ents2Label-mention-ngram: cerebellar granulet%interceding-token ngrams: that belongt#interceding-token ngrams: effect istke1: trigger-arg-path: lemmatizedTrigger=phosphorylate nsubj [lemma='akt'] controllert interceding-token ngrams: belongtte2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt&interceding-token ngrams: of ASK1- andt#e2: args2Role-mention-ngram: ( CGCst;e1: ents2Label-mention-ngram: ASK1 and GENE_OR_GENE_PRODUCTt(e2: args2Role-mention-ngram: CGCs ) alsot(e2: args2Role-mention-ngram: in culturedt5e2: trigger-arg-path: decreases >dobj Phosphorylationt)interceding-token ngrams: the decrease oftce2: trigger-arg-path: decreases:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt-interceding-token ngrams: the MAPKKK upstreamtte2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt&e2: ents2Label-mention-ngram: ( CGCs )t/e2: args2Role-mention-ngram: cerebellar granulet"e1: ents2Label-mention-ngram: ASK1tDe2: trigger-arg-path: decreases >nsubj >prep_of Gene_or_gene_productt2e1: ents2Label-mention-ngram: to phosphorylate andtce1: trigger-arg-path: phosphorylate nsubj [lemma='akt'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: of ASK1t8e2: args2Role-mention-ngram: cultured cerebellar granuletie1: trigger-arg-path: Positive_regulation nsubj [lemma='akt'] Gene_or_gene_productt$interceding-token ngrams: the MAPKKKt#interceding-token ngrams: JNK , andt'interceding-token ngrams: mediated cellt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nsubj [lemma='akt'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: phosphorylate and inhibitt'interceding-token ngrams: effect is thet1e2: args2Role-mention-ngram: decreases CONTROLLEDt&e1: ents2Label-mention-ngram: ASK1 andt&e2: args2Role-mention-ngram: decreasest'e2: ents2Label-mention-ngram: decreasest*e2: args2Role-mention-ngram: granule cellst4interceding-token ngrams: MAPKKK upstream activationtIe2: trigger-arg-path: decreases:Positive_regulation >dobj Phosphorylationt0e2: ents2Label-mention-ngram: SHARED in culturedt@e2: trigger-arg-path: decreases >dobj controlled:Phosphorylationt*interceding-token ngrams: Conversely , thetoe2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj [lemma='phosphorylation'] controlledt0e2: args2Role-mention-ngram: cultured cerebellart,interceding-token ngrams: death . Converselyt#e2: args2Role-mention-ngram: ) alsotDe2: trigger-arg-path: decreases:Positive_regulation >dobj controlledt"e2: ents2Label-mention-ngram: CGCst?e1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='akt'] controller:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtZe2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj Phosphorylationtse2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controllert(interceding-token ngrams: ASK1- and MLK3t.e2: ents2Label-mention-ngram: ) also decreasest0e2: trigger-arg-path: decreases >dobj controlledt#interceding-token ngrams: belong tot&e2: ents2Label-mention-ngram: culturedtie2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >prep_of Gene_or_gene_producttme1: trigger-arg-path: phosphorylate:Positive_regulation nsubj [lemma='akt'] controllert*e2: ents2Label-mention-ngram: cells ( CGCste2: trigger: decreasest?e2: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] Gene_or_gene_producttne1: trigger-arg-path: phosphorylate nsubj [lemma='akt'] controller:Gene_or_gene_productt+interceding-token ngrams: activation of JNKt interceding-token ngrams: MAPKKKtLe2: ents2Label-mention-ngram: decreases GENE_OR_GENE_PRODUCT phosphorylationtle2: trigger-arg-path: Positive_regulation >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controllert:e2: trigger-arg-path: decreases >nsubj >prep_of controllert}e2: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: and inhibit thet+e2: ents2Label-mention-ngram: granule cellst"interceding-token ngrams: of JNK ,t3e2: args2Role-mention-ngram: in cultured cerebellartbe2: trigger-arg-path: decreases >nsubj [lemma='inhibition'] >prep_of [lemma='pi3k-akt'] controllert+interceding-token ngrams: the translocationt*e1: ents2Label-mention-ngram: of HtrA2 andt*e2: ents2Label-mention-ngram: of HtrA2 andtWe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ra'] controller:Familyt.interceding-token ngrams: the translocation oft$interceding-token ngrams: , p53R175Ht.interceding-token ngrams: into mitochondria int&e2: ents2Label-mention-ngram: of HtrA2t'interceding-token ngrams: p38 MAPK intot interceding-token ngrams: this ,t-interceding-token ngrams: p53R175H diminishedt.interceding-token ngrams: Consistent with thist?interceding-tokens-full-span: by increasing the translocation of p38 MAPK into mitochondria in a p53 dependent manner . Consistent with this , p53R175H diminishedt6e2: ents2Label-mention-ngram: phosphorylation of HtrA2t'e2: ents2Label-mention-ngram: HtrA2 andt*interceding-token ngrams: translocation oft(interceding-token ngrams: increasing thet)interceding-token ngrams: mitochondria int"interceding-token ngrams: p53R175Ht5e1: ents2Label-mention-ngram: induces phosphorylationt&e1: ents2Label-mention-ngram: of HtrA2t8e1: ents2Label-mention-ngram: induces phosphorylation oft%interceding-token ngrams: of p38 MAPKt.e2: ents2Label-mention-ngram: HtrA2 and SHAREDt.interceding-token ngrams: translocation of p38t'e1: ents2Label-mention-ngram: HtrA2 andt+interceding-token ngrams: mitochondria in at#interceding-token ngrams: MAPK intot0interceding-token ngrams: MAPK into mitochondriat#e1: ents2Label-mention-ngram: HtrA2t%interceding-token ngrams: with this ,t/interceding-token ngrams: , p53R175H diminishedtnsubj Familyt)interceding-token ngrams: this , p53R175Ht.e1: ents2Label-mention-ngram: HtrA2 and SHAREDt#e2: ents2Label-mention-ngram: HtrA2tJe1: trigger-arg-path: induces:Positive_regulation >nsubj controller:FamilytPe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ra'] controllertLe1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='ra'] Familyt-interceding-token ngrams: manner . Consistentt6e1: ents2Label-mention-ngram: phosphorylation of HtrA2t$CSSPATH: ROOT  ++ ROOT >advcl >ccompt3e1: args2Role-mention-ngram: N-terminus bound THEMEt&interceding-token ngrams: than RAS-GDPt>e2: trigger-arg-path: binds:Binding >dobj [lemma='RAS'] Familyt(e2: args2Role-mention-ngram: ASPP1 bindsthe1: trigger-arg-path: bound:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] Gene_or_gene_productt$interceding-token ngrams: illustratetDe2: trigger-arg-path: Binding >nsubj [lemma='region'] Generic_entityt;e2: trigger-arg-path: Binding >nsubj [lemma='region'] themet'interceding-token ngrams: that only thet)interceding-token ngrams: . To illustratetFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='RAS'] themet'e2: ents2Label-mention-ngram: SHARED oft9e2: trigger-arg-path: binds >nsubj [lemma='region'] themetinterceding-token ngrams: 5 ) .t!interceding-token ngrams: and 5 )t"e2: args2Role-mention-ngram: ASPP1t8e2: trigger-arg-path: Binding >dobj [lemma='RAS'] FamilytYe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='region'] theme:Generic_entityt#interceding-token ngrams: four-foldt7e2: trigger-arg-path: Binding >dobj [lemma='RAS'] themet-e1: args2Role-mention-ngram: N-terminus boundtHe1: trigger-arg-path: bound >dobj [lemma='ras-gtp'] Gene_or_gene_producttPe1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtp'] Gene_or_gene_productt)interceding-token ngrams: illustrate thatt*interceding-token ngrams: four-fold highert-interceding-token ngrams: only the N-terminaltGe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='RAS'] Familyt.interceding-token ngrams: illustrate that onlyt-e2: ents2Label-mention-ngram: SHARED of ASPP1t#interceding-token ngrams: RAS-GDP (tqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtp'] theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: ASPP1t5e1: ents2Label-mention-ngram: SHARED N-terminus boundtOe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='RAS'] Familyt'interceding-token ngrams: To illustratet!interceding-token ngrams: lanes 4t>e2: trigger-arg-path: Binding >dobj [lemma='RAS'] theme:FamilytQe1: trigger-arg-path: bound >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] themet.interceding-token ngrams: higher affinity thante1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: bound >dobj [lemma='ras-gtp'] theme:Gene_or_gene_producttinterceding-token ngrams: 4 andt/e1: ents2Label-mention-ngram: SHARED N-terminust#interceding-token ngrams: that onlyt'interceding-token ngrams: affinity thant.e2: args2Role-mention-ngram: ASPP1 binds THEMEt)interceding-token ngrams: , compare lanest+e2: args2Role-mention-ngram: THEME of ASPP1tVe1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtp'] theme:Gene_or_gene_productt`e1: trigger-arg-path: bound >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] Gene_or_gene_productt.e2: trigger-arg-path: binds >dobj theme:Familyt%e2: args2Role-mention-ngram: of ASPP1t?interceding-tokens-full-span: with a four-fold higher affinity than RAS-GDP ( , compare lanes 4 and 5 ) . To illustrate that only the N-terminaltMe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='RAS'] theme:Familyt6e2: trigger-arg-path: binds:Binding >dobj theme:Familyt%interceding-token ngrams: a four-foldtPe2: trigger-arg-path: binds:Binding >nsubj [lemma='region'] theme:Generic_entityt!interceding-token ngrams: comparet(e2: trigger-arg-path: binds >dobj Familyt3e1: args2Role-mention-ngram: THEME N-terminus boundtinterceding-token ngrams: ( ,t*e2: ents2Label-mention-ngram: binds FAMILYtinterceding-token ngrams: 5tCe1: ents2Label-mention-ngram: N-terminus bound GENE_OR_GENE_PRODUCTtJe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtp'] themet0e2: trigger-arg-path: binds:Binding >dobj Familyt6e2: trigger-arg-path: binds >dobj [lemma='RAS'] FamilytAe1: trigger-arg-path: bound:Binding >dobj [lemma='ras-gtp'] themetHe2: trigger-arg-path: binds >nsubj [lemma='region'] theme:Generic_entityt,interceding-token ngrams: To illustrate thatt#interceding-token ngrams: , comparetbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] themet&e2: ents2Label-mention-ngram: of ASPP1tRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='region'] themet(interceding-token ngrams: than RAS-GDP (tdobj [lemma='RAS'] theme:Familytae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtp'] Gene_or_gene_productt9e1: trigger-arg-path: bound >dobj [lemma='ras-gtp'] themet_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtp'] theme:Gene_or_gene_producttAe2: trigger-arg-path: binds:Binding >nsubj [lemma='region'] themetRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='ras-gtp'] themet%interceding-token ngrams: ( , comparetPe1: trigger-arg-path: Binding >dobj [lemma='ras-gtp'] theme:Gene_or_gene_productt3interceding-token ngrams: four-fold higher affinityt5e2: trigger-arg-path: binds >dobj [lemma='RAS'] themetUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='RAS'] theme:Familyt,interceding-token ngrams: a four-fold highert-e1: args2Role-mention-ngram: THEME N-terminustne1: trigger-arg-path: bound:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='region'] theme:Generic_entitytJe1: trigger-arg-path: Binding >dobj [lemma='ras-gtp'] Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] themetSe1: trigger-arg-path: Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] themetJe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='region'] themet*interceding-token ngrams: with a four-foldt%interceding-token ngrams: lanes 4 andt[e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='region'] Generic_entityt!interceding-token ngrams: 4 and 5t%interceding-token ngrams: RAS-GDP ( ,t,e2: ents2Label-mention-ngram: of ASPP1 bindst+e2: args2Role-mention-ngram: of ASPP1 bindstDe2: trigger-arg-path: binds:Binding >dobj [lemma='RAS'] theme:Familytbe1: trigger-arg-path: Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] Gene_or_gene_producttfe1: trigger-arg-path: bound >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='ras-gtp'] Gene_or_gene_producttinterceding-token ngrams: 5 )tNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='RAS'] themetJe2: trigger-arg-path: binds:Binding >nsubj [lemma='region'] Generic_entitytinterceding-token ngrams: and 5t.e1: ents2Label-mention-ngram: N-terminus boundt)interceding-token ngrams: compare lanes 4t!interceding-token ngrams: RAS-GDPt;e1: trigger-arg-path: Binding >dobj [lemma='ras-gtp'] themetwe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] theme:Gene_or_gene_producttinterceding-token ngrams: lanest=e2: trigger-arg-path: binds:Binding >dobj [lemma='RAS'] themetBe2: trigger-arg-path: binds >nsubj [lemma='region'] Generic_entityt)interceding-token ngrams: higher affinitytae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='region'] theme:Generic_entityt/interceding-token ngrams: affinity than RAS-GDPtYe1: trigger-arg-path: bound:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] themethe1: trigger-arg-path: Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='region'] Generic_entityt"interceding-token ngrams: only thet'interceding-token ngrams: compare lanest%e2: args2Role-mention-ngram: THEME oftye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='n-terminus'] >nn [lemma='aspp1'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: ASPP1 binds FAMILYt)e2: ents2Label-mention-ngram: ASPP1 bindst)interceding-token ngrams: to dissociationt/interceding-token ngrams: guanine nucleotides .tQe1: trigger-arg-path: binds >dobj [lemma='pi3kc2beta'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlledtMe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='ra'] Familyt`e2: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='lipid'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj FamilytJe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ra'] Familyt%interceding-token ngrams: nucleotidest@e2: trigger-arg-path: inhibits:Negative_activation >nsubj Familyt,e2: trigger-arg-path: inhibits >nsubj FamilytVe2: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='lipid'] controlledt4interceding-token ngrams: refractory to dissociationt+interceding-token ngrams: that this complextke2: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='lipid'] controlled:Gene_or_gene_productt+interceding-token ngrams: , nucleotide-freet|e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='lipid'] controlled:Gene_or_gene_productt1interceding-token ngrams: dissociation by guaninetMe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3kc2beta'] themetHe2: trigger-arg-path: Negative_activation >nsubj [lemma='ra'] controllert0interceding-token ngrams: by guanine nucleotidestXe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='ra'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: binds:Binding >dobj [lemma='pi3kc2beta'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ra'] controllertUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3kc2beta'] themetOe2: trigger-arg-path: Negative_activation >nsubj [lemma='ra'] controller:Familyt)interceding-token ngrams: dissociation bytDe1: trigger-arg-path: binds:Binding >dobj [lemma='pi3kc2beta'] themet7e2: trigger-arg-path: Negative_activation >nsubj Familyt)interceding-token ngrams: nucleotide-freetve2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlled:Gene_or_gene_productt$interceding-token ngrams: by guaninet=e2: trigger-arg-path: inhibits >nsubj [lemma='ra'] controllert\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3kc2beta'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='pi3kc2beta'] theme:Gene_or_gene_productt*interceding-token ngrams: is refractory totHe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj controller:Familyt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='ra'] Familyt'interceding-token ngrams: nucleotides .t/interceding-token ngrams: complex is refractoryt9e2: trigger-arg-path: inhibits >nsubj [lemma='ra'] Familytbe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='ra'] controllertje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3kc2beta'] theme:Gene_or_gene_productt=e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj Familyt\e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj controller:FamilytMe1: trigger-arg-path: Binding >dobj [lemma='pi3kc2beta'] Gene_or_gene_producttQe2: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='ra'] controllertde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='pi3kc2beta'] Gene_or_gene_productt'interceding-token ngrams: is refractoryt'interceding-token ngrams: refractory totBe2: trigger-arg-path: Negative_activation >nsubj controller:FamilytDe2: trigger-arg-path: inhibits >nsubj [lemma='ra'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] Gene_or_gene_producttSe1: trigger-arg-path: Binding >dobj [lemma='pi3kc2beta'] theme:Gene_or_gene_producttje2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlledt)interceding-token ngrams: this complex iste2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlled:Gene_or_gene_productt-interceding-token ngrams: guanine nucleotidestdobj [lemma='pi3kc2beta'] themetKe2: trigger-arg-path: inhibits:Negative_activation >nsubj controller:Familyt4e2: args2Role-mention-ngram: inhibits the CONTROLLEDt,interceding-token ngrams: to dissociation bytqe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='lipid'] Gene_or_gene_productt?interceding-tokens-full-span: and that this complex is refractory to dissociation by guanine nucleotides . Furthermore , nucleotide-freetke2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] Gene_or_gene_producttYe1: trigger-arg-path: binds:Binding >dobj [lemma='pi3kc2beta'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ra'] controller:Familyt?e2: ents2Label-mention-ngram: inhibits the GENE_OR_GENE_PRODUCTtie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='ra'] controller:Familyt3interceding-token ngrams: nucleotides . Furthermoret7interceding-token ngrams: Furthermore , nucleotide-freet>e1: trigger-arg-path: Binding >dobj [lemma='pi3kc2beta'] themetDe2: trigger-arg-path: Negative_activation >nsubj [lemma='ra'] Familytae2: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] controlledt7e2: trigger-arg-path: inhibits >nsubj controller:FamilytKe1: trigger-arg-path: binds >dobj [lemma='pi3kc2beta'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='lipid'] controlledt$interceding-token ngrams: refractorytte2: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='lipid'] Gene_or_gene_producttCe1: trigger-arg-path: directly activated nsubjpass Bindingt.e1: args2Role-mention-ngram: CONTROLLED and ist#e1: args2Role-mention-ngram: and ist3e1: ents2Label-mention-ngram: is directly activatedt\e2: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] controlled:Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn Complext2e1: args2Role-mention-ngram: is directly activatedt+e1: ents2Label-mention-ngram: FAMILY and istRe2: trigger-arg-path: activation:Positive_activation >nn [lemma='pi3k'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass [lemma='pi3k'] controlledt|e1: trigger-arg-path: directly activated:Positive_regulation nsubjpass [lemma='pi3k'] controlledt)e1: ents2Label-mention-ngram: is directlyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass [lemma='pi3k'] Bindingt?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] Complextye2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi3k'] controlled:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='rtk'] controller:Gene_or_gene_producttNe1: trigger-arg-path: directly activated agent >nn controller:Complext@e2: ents2Label-mention-ngram: activation by GENE_OR_GENE_PRODUCTt,e1: args2Role-mention-ngram: and is directlyt?e1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='pi3k'] controlled:Bindingtke1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass controlledtfe1: trigger-arg-path: Positive_regulation nsubjpass [lemma='pi3k'] Bindingtve1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='pi3k'] Bindingtge2: trigger-arg-path: activation:Positive_activation >nn [lemma='pi3k'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='rtk'] controllertqe1: trigger-arg-path: Positive_regulation nsubjpass [lemma='pi3k'] controlled:BindingtPe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi3k'] controlledtTe1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn Complext`e2: trigger-arg-path: Positive_activation >prep_by [lemma='rtk'] controller:Gene_or_gene_producttye1: trigger-arg-path: directly activated:Positive_regulation nsubjpass [lemma='pi3k'] Bindingt_e1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass controlled:BindingtOe1: trigger-arg-path: Positive_regulation agent >nn controller:ComplextWe1: trigger-arg-path: directly activated:Positive_regulation nsubjpass BindingtGe2: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] controlledtye1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass [lemma='pi3k'] controlledt)e1: ents2Label-mention-ngram: with FAMILYt?e1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] controller:Complextre2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='rtk'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='rtk'] controller:Gene_or_gene_producttHe2: trigger-arg-path: activation >nn [lemma='pi3k'] Gene_or_gene_producttbe1: trigger-arg-path: directly activated:Positive_regulation nsubjpass controlled:Bindingt(e1: args2Role-mention-ngram: is directlytDe1: trigger-arg-path: Positive_regulation agent >nn Complext?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:Complextee2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi3k'] controlled:Gene_or_gene_producttke2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='rtk'] controller:Gene_or_gene_productt%interceding-tokens-full-span: [ - ] .tUe2: trigger-arg-path: Positive_activation >prep_by [lemma='rtk'] Gene_or_gene_producttCe1: trigger-arg-path: directly activated agent >nn ComplextGe1: trigger-arg-path: Positive_regulation nsubjpass controlledt\e2: trigger-arg-path: activation:Positive_activation >nn [lemma='pi3k'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=directly activate agent [lemma='binding'] >nn [lemma='ra'] controller:Complext1e1: ents2Label-mention-ngram: activated by FAMILYtse1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass controlled:BindingtZe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='pi3k'] Gene_or_gene_producttve1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Complexthe1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass Bindingt?e1: trigger-arg-path: Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:ComplextSe2: trigger-arg-path: activation >nn [lemma='pi3k'] controlled:Gene_or_gene_producttee1: trigger-arg-path: directly activated nsubjpass [lemma='pi3k'] Bindingtpe1: trigger-arg-path: directly activated nsubjpass [lemma='pi3k'] controlled:Bindingt-e1: ents2Label-mention-ngram: with FAMILY andtBe2: trigger-arg-path: activation >prep_by [lemma='rtk'] controllert?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Complext,e1: ents2Label-mention-ngram: FAMILY bindingtue1: trigger-arg-path: directly activated agent [lemma='binding'] >nn [lemma='ra'] Complext/e1: ents2Label-mention-ngram: FAMILY binding tot3e1: ents2Label-mention-ngram: interacts with FAMILYt/e1: ents2Label-mention-ngram: by FAMILY bindingtLe2: trigger-arg-path: activation >prep_by [lemma='rtk'] Gene_or_gene_producttZe1: trigger-arg-path: directly activated:Positive_regulation nsubjpass controlledtie1: trigger-arg-path: Positive_regulation nsubjpass [lemma='pi3k'] controlledtde2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi3k'] controlledtQe2: trigger-arg-path: Positive_activation >nn [lemma='pi3k'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >nn [lemma='pi3k'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_by [lemma='rtk'] controllert-e1: ents2Label-mention-ngram: and is directlyt?e1: trigger-arg-path: directly activated:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] Complext$e1: ents2Label-mention-ngram: and istTe1: trigger-arg-path: lemmatizedTrigger=directly activate nsubjpass BindingtKe2: trigger-arg-path: Positive_activation >prep_by [lemma='rtk'] controllerthe1: trigger-arg-path: directly activated nsubjpass [lemma='pi3k'] controlledtse1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent >nn controller:ComplextWe2: trigger-arg-path: activation >prep_by [lemma='rtk'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=directly activate agent >nn controller:ComplextOe1: trigger-arg-path: Positive_regulation nsubjpass controlled:Bindingt^e2: trigger-arg-path: lemmatizedTrigger=activation >prep_by [lemma='rtk'] Gene_or_gene_producttWe1: trigger-arg-path: directly activated:Positive_regulation agent >nn Complext?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation agent [lemma='binding'] >nn [lemma='ra'] controller:ComplextNe1: trigger-arg-path: directly activated nsubjpass controlled:Bindingt?e1: trigger-arg-path: lemmatizedTrigger=directly activate:Positive_regulation nsubjpass [lemma='pi3k'] controlled:Bindingt?e1: trigger-arg-path: directly activated:Positive_regulation nsubjpass [lemma='pi3k'] controlled:BindingtVe2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='rtk'] controllertbe1: trigger-arg-path: directly activated:Positive_regulation agent >nn controller:Complext>e2: trigger-arg-path: activation >nn [lemma='pi3k'] controlledt`e2: trigger-arg-path: activation:Positive_activation >prep_by [lemma='rtk'] Gene_or_gene_producttDe1: trigger-arg-path: Positive_regulation nsubjpass Bindingtne1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38mapk'] controller:Gene_or_gene_productt(interceding-tokens-full-span: and T390 .tTe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='erk'] controllertme1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38mapk'] controllerthe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='erk'] controllert!e2: ents2Label-mention-ngram: T43t\e1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38mapk'] controllert^e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='erk'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: at T43tre2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='erk'] Gene_or_gene_productt]e1: trigger-arg-path: phosphorylates >nsubj [lemma='p38mapk'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38mapk'] Gene_or_gene_producttBe2: trigger-arg-path: phosphorylation >nn [lemma='erk'] controllert%e1: ents2Label-mention-ngram: at S389t$interceding-token ngrams: and T390 .t+e2: ents2Label-mention-ngram: SHARED at T43tce1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38mapk'] Gene_or_gene_producttke2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='erk'] controller:Gene_or_gene_producttHe1: trigger-arg-path: phosphorylates >nsubj [lemma='p38mapk'] controllert}e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='erk'] controller:Gene_or_gene_producttVe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='erk'] controllertbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38mapk'] controller:Gene_or_gene_producttqe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38mapk'] controller:Gene_or_gene_producttWe2: trigger-arg-path: phosphorylation >nn [lemma='erk'] controller:Gene_or_gene_producttFe2: trigger-arg-path: Positive_regulation >nn [lemma='erk'] controllertPe2: trigger-arg-path: Positive_regulation >nn [lemma='erk'] Gene_or_gene_productt interceding-token ngrams: T390 .t,e1: ents2Label-mention-ngram: SHARED at S389t?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='p38mapk'] controller:Gene_or_gene_productt[e2: trigger-arg-path: Positive_regulation >nn [lemma='erk'] controller:Gene_or_gene_producttRe1: trigger-arg-path: phosphorylates >nsubj [lemma='p38mapk'] Gene_or_gene_producttMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38mapk'] controllert"e1: ents2Label-mention-ngram: S389tWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='p38mapk'] Gene_or_gene_producttinterceding-token ngrams: T390t"interceding-token ngrams: and T390tYe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='p38mapk'] controllert`e2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='erk'] Gene_or_gene_producttfe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='p38mapk'] Gene_or_gene_producttLe2: trigger-arg-path: phosphorylation >nn [lemma='erk'] Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='erk'] controller:Gene_or_gene_productt3interceding-token ngrams: inflammatory and cytokinet&interceding-token ngrams: and cytokinet6interceding-token ngrams: factor-beta-activated kinaset-interceding-token ngrams: to inflammatory andt"interceding-token ngrams: kinase 1t1interceding-token ngrams: and cytokine signallingt3interceding-token ngrams: signalling . ASK1inhibitst,interceding-token ngrams: kinase involved int/interceding-token ngrams: cytokine signalling .t3interceding-token ngrams: activation by interferingt(interceding-token ngrams: . ASK1inhibitst=e1: trigger-arg-path: Binding >prep_with [lemma='tak1'] themet interceding-token ngrams: in NFBtee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tak1'] theme:Gene_or_gene_productt*interceding-token ngrams: inflammatory andtTe1: trigger-arg-path: interacts >prep_with [lemma='tak1'] theme:Gene_or_gene_productt(interceding-token ngrams: NFB activationtHe1: trigger-arg-path: Binding >nsubj [lemma='ask1'] Gene_or_gene_productt&interceding-token ngrams: ASK1inhibitstGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='tak1'] themetce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ask1'] Gene_or_gene_producttinterceding-token ngrams: NFBt+interceding-token ngrams: in NFB activationt/interceding-token ngrams: factor-beta-activatedtPe1: trigger-arg-path: interacts >nsubj [lemma='ask1'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tak1'] themet'interceding-token ngrams: activation byt8interceding-token ngrams: factor-beta-activated kinase 1t9e1: trigger-arg-path: Binding >nsubj [lemma='ask1'] themetCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ask1'] themetACSSPATH: ROOT >ccomp ++ ROOT >nsubj >prepc_by >prep_with >prep_oftRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ask1'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ask1'] themet6interceding-token ngrams: growth factor-beta-activatedt*interceding-token ngrams: ASK1inhibits NFBt/interceding-token ngrams: ( transforming growtht)interceding-token ngrams: kinase involvedtXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tak1'] themetRe1: trigger-arg-path: Binding >prep_with [lemma='tak1'] theme:Gene_or_gene_productt&interceding-token ngrams: inflammatorytNe1: trigger-arg-path: Binding >nsubj [lemma='ask1'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tak1'] theme:Gene_or_gene_productt+interceding-token ngrams: NFB activation byt-interceding-token ngrams: transforming growtht)interceding-token ngrams: involved in NFBtCinterceding-token ngrams: transforming growth factor-beta-activatedtXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='ask1'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='tak1'] Gene_or_gene_producttVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='tak1'] Gene_or_gene_productt2interceding-token ngrams: response to inflammatorytLe1: trigger-arg-path: Binding >prep_with [lemma='tak1'] Gene_or_gene_productt)interceding-token ngrams: to inflammatorytEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT directly interactst&interceding-token ngrams: transformingt+interceding-token ngrams: NFB activation intTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ask1'] themet?e1: trigger-arg-path: interacts >prep_with [lemma='tak1'] themetinterceding-token ngrams: 1 ) ,tie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='ask1'] theme:Gene_or_gene_productt=interceding-token ngrams: growth factor-beta-activated kinaset+interceding-token ngrams: a kinase involvedt$interceding-token ngrams: , a kinasetae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ask1'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='ask1'] Gene_or_gene_productt?interceding-tokens-full-span: ( transforming growth factor-beta-activated kinase 1 ) , a kinase involved in NFB activation in response to inflammatory and cytokine signalling . ASK1inhibits NFB activation by interfering with the formation of thet"interceding-token ngrams: cytokinet-interceding-token ngrams: cytokine signallingt&interceding-token ngrams: signalling .tNe1: trigger-arg-path: interacts >prep_with [lemma='tak1'] Gene_or_gene_productt,interceding-token ngrams: with the formationt5interceding-token ngrams: ASK1inhibits NFB activationtge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='tak1'] Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='ask1'] Gene_or_gene_productt.interceding-token ngrams: interfering with thet;e1: trigger-arg-path: interacts >nsubj [lemma='ask1'] themet,interceding-token ngrams: . ASK1inhibits NFBt$interceding-token ngrams: kinase 1 )t\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='tak1'] theme:Gene_or_gene_productt(interceding-token ngrams: ( transformingt=e2: trigger-arg-path: inactivates >nsubj Gene_or_gene_producttDe1: trigger-arg-path: complex >nn [lemma='gtp'] Gene_or_gene_productt3e2: trigger-arg-path: inactivates >nsubj controllertXe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj controllert0e2: args2Role-mention-ngram: by accelerating thet/e2: args2Role-mention-ngram: inactivates Ras bytbe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj Gene_or_gene_productt,e2: args2Role-mention-ngram: by acceleratingt-e2: args2Role-mention-ngram: accelerating thet=e1: trigger-arg-path: complex:Binding >nn [lemma='gtp'] themet8e2: args2Role-mention-ngram: accelerating the conversiont(e2: ents2Label-mention-ngram: conversiontOe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] themet0e2: args2Role-mention-ngram: Ras by acceleratingtie2: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj controller:Gene_or_gene_producttBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inactivates Rast'e2: ents2Label-mention-ngram: of activet&e2: args2Role-mention-ngram: of activet_e2: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] controllert'e2: args2Role-mention-ngram: conversiontDe1: trigger-arg-path: Binding >nn [lemma='gtp'] Gene_or_gene_producttnn [lemma='gtp'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >nn [lemma='gtp'] theme:Gene_or_gene_productt>e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inactivatest)e2: args2Role-mention-ngram: acceleratingtNe2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj Gene_or_gene_productt.e2: args2Role-mention-ngram: the conversion oftKe2: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] controllert\e2: trigger-arg-path: inactivates:Negative_regulation >nsubj controller:Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_producttHe2: trigger-arg-path: inactivates >nsubj controller:Gene_or_gene_productt+e2: args2Role-mention-ngram: the conversiont]e2: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt5e1: trigger-arg-path: Binding >nn [lemma='gtp'] themet,e2: ents2Label-mention-ngram: the conversiont7e2: args2Role-mention-ngram: CONTROLLER inactivates Rast5e1: trigger-arg-path: complex >nn [lemma='gtp'] themet\e2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] controllert/e2: ents2Label-mention-ngram: the conversion oftVe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] Gene_or_gene_producttGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] themet?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_productt1e2: args2Role-mention-ngram: of active CONTROLLEDtRe1: trigger-arg-path: complex:Binding >nn [lemma='gtp'] theme:Gene_or_gene_producttDe2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj controllert`e2: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttte2: trigger-arg-path: inactivates:Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >nsubj [lemma='Neurofibromin'] controllerte2: trigger: inactivatestnsubj Gene_or_gene_productt-e2: ents2Label-mention-ngram: by acceleratingt$e2: ents2Label-mention-ngram: Ras byt#CSSPATH: ROOT >xcomp >dobj ++ ROOT t*e2: args2Role-mention-ngram: conversion oftGe2: trigger-arg-path: inactivates:Negative_regulation >nsubj controllertSe2: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] controllert.e2: args2Role-mention-ngram: active CONTROLLEDtLe1: trigger-arg-path: complex:Binding >nn [lemma='gtp'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: Ras by acceleratingt-e2: ents2Label-mention-ngram: inactivates Rasthe2: trigger-arg-path: Negative_regulation >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj controller:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='gtp'] theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: conversion of activet1e2: ents2Label-mention-ngram: by accelerating thetqe2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: accelerating thet^e1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='gtp'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: conversion oft#e2: args2Role-mention-ngram: Ras bytfe2: trigger-arg-path: lemmatizedTrigger=inactivate >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: acceleratingtUe2: trigger-arg-path: inactivates >nsubj [lemma='Neurofibromin'] Gene_or_gene_productt,e2: args2Role-mention-ngram: inactivates Rast2e2: ents2Label-mention-ngram: conversion of activet0e2: ents2Label-mention-ngram: inactivates Ras bytfe1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt=e1-label: Positive_activation + e2-label: Positive_activationtFe2: trigger-arg-path: induces:Positive_activation >dobj >nn controlledt-interceding-token ngrams: dependent elevationt?e1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttPe2: trigger-arg-path: induces:Positive_activation >dobj >nn Gene_or_gene_productt+interceding-token ngrams: NK lymphoma cellstJe2: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt'interceding-token ngrams: of telomerasetYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='il-2'] Gene_or_gene_productt6interceding-token ngrams: HTLV-1-transformed T-cells .t1interceding-token ngrams: elevation of telomeraset8interceding-token ngrams: activity in HTLV-1-transformedt4interceding-token ngrams: recently demonstrated thattJe1: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] controllertQe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='il-2'] controllertge2: trigger-arg-path: induces:Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_producttinterceding-token ngrams: , Ourtwe1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt0interceding-token ngrams: telomerase activity intie1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_producttfe1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt?e1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: induces >nsubj [lemma='il-2'] Gene_or_gene_productt_e1: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_productt+interceding-token ngrams: and Akt dependentt\e1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt,interceding-token ngrams: lymphoma cells andt(interceding-token ngrams: lymphoma cellst0interceding-token ngrams: dependent elevation oft/interceding-token ngrams: in HTLV-1-transformedtde2: trigger-arg-path: induces >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt interceding-token ngrams: a PI3KtOe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='il-2'] controllert[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='il-2'] Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='il-2'] controller:Gene_or_gene_producttinterceding-token ngrams: NKt;e1: trigger-arg-path: increases >nsubj Gene_or_gene_producttpe1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt>e2: trigger-arg-path: induces >nsubj [lemma='il-2'] controllert^e1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_productt#interceding-token ngrams: T-cells .txe2: trigger-arg-path: induces:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_producttCe2: trigger-arg-path: induces:Positive_activation >nsubj controllert1interceding-token ngrams: Akt dependent elevationt&interceding-token ngrams: cells and ist/interceding-token ngrams: recently demonstratedtue2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='il-2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_productt%interceding-token ngrams: NK lymphomatFe1: trigger-arg-path: increases >nsubj controller:Gene_or_gene_productt&interceding-token ngrams: elevation oftOe1: trigger-arg-path: increases:Positive_activation >nsubj Gene_or_gene_productt[e2: trigger-arg-path: induces:Positive_activation >dobj >nn controlled:Gene_or_gene_producttJe1: trigger-arg-path: increases >nsubj [lemma='il-2'] Gene_or_gene_productt0interceding-token ngrams: of telomerase activityt%interceding-token ngrams: , Our groupt!interceding-token ngrams: T-cellstme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_productt4interceding-token ngrams: HTLV-1-transformed T-cellst?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='il-2'] controller:Gene_or_gene_productt,interceding-token ngrams: HTLV-1-transformedtme1: trigger-arg-path: lemmatizedTrigger=increase >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt{e2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_productt_e2: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_producttZe1: trigger-arg-path: increases:Positive_activation >nsubj controller:Gene_or_gene_producttpe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_producttTe1: trigger-arg-path: increases:Positive_activation >nsubj [lemma='il-2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt{e1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttXe2: trigger-arg-path: induces:Positive_activation >nsubj controller:Gene_or_gene_productt%interceding-token ngrams: T-cells . ,tSe2: trigger-arg-path: induces >nsubj [lemma='il-2'] controller:Gene_or_gene_producttRe2: trigger-arg-path: induces:Positive_activation >nsubj [lemma='il-2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_productt?interceding-tokens-full-span: activity in NK lymphoma cells and is associated with a PI3K and Akt dependent elevation of telomerase activity in HTLV-1-transformed T-cells . , Our group recently demonstrated thattMe2: trigger-arg-path: induces:Positive_activation >nsubj Gene_or_gene_productt,interceding-token ngrams: Our group recentlytne2: trigger-arg-path: induces:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt#interceding-token ngrams: Our groupt-interceding-token ngrams: telomerase activityt(interceding-token ngrams: group recentlytoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_productt!interceding-token ngrams: . , Ourt+interceding-token ngrams: associated with at%interceding-token ngrams: with a PI3Ktinterceding-token ngrams: in NKt'interceding-token ngrams: Akt dependentt(interceding-token ngrams: activity in NKtZe2: trigger-arg-path: induces >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledtTe2: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_producttUe1: trigger-arg-path: increases >nsubj [lemma='il-2'] controller:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_productt\e2: trigger-arg-path: induces:Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='il-2'] controllert5interceding-token ngrams: group recently demonstratedtfe2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt?e2: trigger-arg-path: induces:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttinterceding-token ngrams: groupt7interceding-token ngrams: in HTLV-1-transformed T-cellst?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=increase:Positive_activation >nsubj [lemma='il-2'] controller:Gene_or_gene_productt$interceding-token ngrams: telomerasetpe1: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt&interceding-token ngrams: PI3K and Akttze1: trigger-arg-path: increases:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] Gene_or_gene_productt@e1: trigger-arg-path: increases >nsubj [lemma='il-2'] controllertqe1: trigger-arg-path: increases >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_producttoe2: trigger-arg-path: induces >dobj [lemma='activity'] >nn [lemma='telomerase'] controlled:Gene_or_gene_productt"interceding-token ngrams: lymphomatke2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt$interceding-token ngrams: a PI3K andtTe1: trigger-arg-path: Positive_activation >nsubj [lemma='il-2'] Gene_or_gene_productt(interceding-token ngrams: in NK lymphomat#interceding-token ngrams: elevationte2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activity'] >nn [lemma='telomerase'] controlledt%e2: args2Role-mention-ngram: where itt\e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation amod controllert,e2: args2Role-mention-ngram: it is necessarytMe2: trigger-arg-path: lemmatizedTrigger=allow prep_of [lemma='ra'] Familyt_e1: trigger-arg-path: activation:Positive_activation amod controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: necessary tot,interceding-token ngrams: its recruitment oftme1: trigger-arg-path: lemmatizedTrigger=activation amod [lemma='epidermal'] controllertHe1: trigger-arg-path: activation >prep_of [lemma='ra'] controlled:Familyt[e1: trigger-arg-path: activation amod [lemma='epidermal'] controllert&interceding-token ngrams: However , PAtpe2: trigger-arg-path: allow:Positive_regulation prep_of [lemma='ra'] controlled:Familyt"e2: args2Role-mention-ngram: it ist*e2: ents2Label-mention-ngram: SHARED wheretpe1: trigger-arg-path: activation amod [lemma='epidermal'] controller:Gene_or_gene_productt0e2: trigger-arg-path: allow prep_of controlled:Familyt)e1: ents2Label-mention-ngram: ) - inducedtJe1: trigger-arg-path: Positive_activation >prep_of [lemma='ra'] controlledt>e2: trigger-arg-path: Positive_regulation prep_of [lemma='ra'] controlledt2e1: ents2Label-mention-ngram: - induced activationt]e1: trigger-arg-path: lemmatizedTrigger=activation amod controller:Gene_or_gene_productt#e1: ents2Label-mention-ngram: ( EGFtoe1: trigger-arg-path: activation:Positive_activation amod [lemma='epidermal'] controllertwe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_regulation prep_of [lemma='ra'] controlledt%interceding-token ngrams: PA seems tote1: args2Role-mention-ngram: -t!interceding-token ngrams: to alsot,interceding-token ngrams: membrane . Howevert2e2: ents2Label-mention-ngram: allow SHARED bindingtQe1: trigger-arg-path: Positive_activation >prep_of [lemma='ra'] controlled:Familyt*e2: ents2Label-mention-ngram: is necessarytDe1: trigger-arg-path: activation:Positive_activation >prep_of Familyt"e1: args2Role-mention-ngram: ( EGFt e1: args2Role-mention-ngram: ) -t e2: ents2Label-mention-ngram: itt?interceding-tokens-full-span: because of its recruitment of the guanine nucleotide-exchange factor SOS to the plasma membrane . However , PA seems to also exert effects downstream oftJe1: trigger-arg-path: activation:Positive_activation amod controllert8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT ( EGFt;e1: trigger-arg-path: activation >prep_of controlled:Familyt+interceding-token ngrams: plasma membrane .tHe2: trigger-arg-path: allow:Positive_regulation amod [lemma='epidermal'] controllerte2: args2Role-mention-ngram: ittce2: trigger-arg-path: lemmatizedTrigger=allow amod [lemma='epidermal'] controller:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=activation amod Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=activation amod controllert6e1: trigger-arg-path: activation amod controllertZe2: trigger-arg-path: lemmatizedTrigger=allow:Positive_regulation prep_of [lemma='ra'] controlled:Familyt-e1: args2Role-mention-ngram: CONTROLLER ( EGFt0e2: args2Role-mention-ngram: CONTROLLER where itt$e1: args2Role-mention-ngram: ( EGF )t(e2: args2Role-mention-ngram: where it istne1: trigger-arg-path: Positive_activation amod [lemma='epidermal'] Gene_or_gene_producttye1: trigger-arg-path: activation:Positive_activation amod [lemma='epidermal'] Gene_or_gene_productt1e1: args2Role-mention-ngram: - induced activationt&e1: args2Role-mention-ngram: - inducedt$interceding-token ngrams: also exertt)e2: args2Role-mention-ngram: necessary tot-e2: args2Role-mention-ngram: CONTROLLER wheret(interceding-token ngrams: of the guaninetQe2: trigger-arg-path: allow prep_of [lemma='ra'] Familyt)e2: args2Role-mention-ngram: is necessaryt@e1: trigger-arg-path: activation amod Gene_or_gene_productt'interceding-token ngrams: exert effectstOe1: trigger-arg-path: activation:Positive_activation >prep_of controlled:Familyt?e1: trigger-arg-path: activation:Positive_activation amod [lemma='epidermal'] controller:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation amod controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: EGF ) -t$e1: args2Role-mention-ngram: EGF ) -t$interceding-token ngrams: , PA seemstTe1: trigger-arg-path: activation:Positive_activation amod Gene_or_gene_productt'e2: ents2Label-mention-ngram: necessaryt*e2: ents2Label-mention-ngram: allow SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=activation amod [lemma='epidermal'] controller:Gene_or_gene_productt$interceding-token ngrams: SOS to thet-e2: ents2Label-mention-ngram: to allow SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation amod [lemma='epidermal'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation amod controllertinterceding-token ngrams: , PAt'interceding-token ngrams: seems to alsotce1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='ra'] Familytye1: trigger-arg-path: Positive_activation amod [lemma='epidermal'] controller:Gene_or_gene_producttKe1: trigger-arg-path: activation amod controller:Gene_or_gene_producttee2: trigger-arg-path: allow:Positive_regulation prep_of controlled:FamilytUe2: trigger-arg-path: allow prep_of [lemma='ra'] controlled:Familyt interceding-token ngrams: SOS tot-e2: ents2Label-mention-ngram: it is necessaryt"e2: args2Role-mention-ngram: allowt0e2: ents2Label-mention-ngram: necessary to allowtde1: trigger-arg-path: Positive_activation amod [lemma='epidermal'] controllertIe1: trigger-arg-path: Positive_activation amod Gene_or_gene_productt"interceding-token ngrams: PA seemst&e2: args2Role-mention-ngram: necessaryt#e1: ents2Label-mention-ngram: EGF )tge1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of [lemma='ra'] controlledtDe2: trigger-arg-path: allow:Positive_regulation prep_of controlled:Familyt0e1: trigger-arg-path: activation >prep_of Familytee1: trigger-arg-path: activation amod [lemma='epidermal'] Gene_or_gene_productt%e2: args2Role-mention-ngram: to allowt-e2: ents2Label-mention-ngram: is necessary tot-e2: args2Role-mention-ngram: allow CONTROLLEDtOe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='ra'] Familyt#e2: ents2Label-mention-ngram: wheret-e2: ents2Label-mention-ngram: SHARED where ittae2: trigger-arg-path: lemmatizedTrigger=allow:Positive_regulation prep_of [lemma='ra'] Familytinterceding-token ngrams: PAt,interceding-token ngrams: also exert effectst!e1: ents2Label-mention-ngram: EGFtOe2: trigger-arg-path: allow:Positive_regulation amod [lemma='epidermal'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=activation:Positive_activation >prep_of FamilytTe1: trigger-arg-path: Positive_activation amod controller:Gene_or_gene_producttBe2: trigger-arg-path: Positive_regulation prep_for >dep ++ ROOT >xcomp >prep_of >rcmod >xcomptSe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of [lemma='ra'] controlledtce2: trigger-arg-path: Positive_regulation prep_of FamilytBe1: trigger-arg-path: lemmatizedTrigger=activation >prep_of Familyte2: trigger: allowt,e2: args2Role-mention-ngram: is necessary totIe2: trigger-arg-path: Positive_regulation amod Gene_or_gene_productt9interceding-token ngrams: the guanine nucleotide-exchangetee2: trigger-arg-path: Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: proteins : eukaryotict?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] Gene_or_gene_productt#e1: ents2Label-mention-ngram: 4E- (tginterceding-tokens-full-span: - ) binding protein ( 4E-BP1 ) and p70 S6 kinase . Upon phosphorylation ,t6e1: ents2Label-mention-ngram: : eukaryotic translationtOe1: trigger-arg-path: phosphorylates >nsubj [lemma='mtor'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mtor'] controllert)e1: ents2Label-mention-ngram: translationt+interceding-token ngrams: binding protein (tLe2: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] Gene_or_gene_producttZe1: trigger-arg-path: phosphorylates >nsubj [lemma='mtor'] controller:Gene_or_gene_productt*interceding-token ngrams: protein ( 4E-BP1t;e1: ents2Label-mention-ngram: translation initiation factort#e2: args2Role-mention-ngram: longertee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: machinery proteins :t.e2: ents2Label-mention-ngram: longer interactst4e1: ents2Label-mention-ngram: translation initiationt'e2: ents2Label-mention-ngram: no longert*e1: ents2Label-mention-ngram: 4E- ( SHAREDt(e1: ents2Label-mention-ngram: factor 4E-t&e2: args2Role-mention-ngram: no longert=e2: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] themetXe2: trigger-arg-path: interacts >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] themet0e2: args2Role-mention-ngram: no longer interactstqe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] themetTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtor'] Gene_or_gene_productt e2: ents2Label-mention-ngram: not$interceding-token ngrams: ( 4E-BP1 )tinterceding-token ngrams: p70tue2: trigger-arg-path: interacts:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] theme:Gene_or_gene_producttEe2: trigger-arg-path: interacts:Binding >nsubj [lemma='4e-bp1'] themet~e2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] theme:Gene_or_gene_productt+interceding-token ngrams: ) binding proteint+e1: ents2Label-mention-ngram: translationalt%interceding-token ngrams: - ) bindingt0e1: ents2Label-mention-ngram: machinery proteinstYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtor'] controllertje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mtor'] controllert%e2: args2Role-mention-ngram: THEME not4e1: ents2Label-mention-ngram: eukaryotic translationt(e1: ents2Label-mention-ngram: initiationt>e1: ents2Label-mention-ngram: translational machinery proteinst!interceding-token ngrams: and p70t.interceding-token ngrams: Upon phosphorylationte2: args2Role-mention-ngram: not(e1: ents2Label-mention-ngram: eukaryotict/e2: args2Role-mention-ngram: with and repressestie2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] themet*e1: ents2Label-mention-ngram: factor 4E- (tPe2: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_producttZe2: trigger-arg-path: interacts:Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt'e1: ents2Label-mention-ngram: machineryt$interceding-token ngrams: and p70 S6t0interceding-token ngrams: . Upon phosphorylationt/e1: ents2Label-mention-ngram: initiation factortce2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_producttke2: trigger-arg-path: Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] theme:Gene_or_gene_productt)interceding-token ngrams: binding proteint3e2: ents2Label-mention-ngram: longer interacts withtoe2: trigger-arg-path: interacts:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] Gene_or_gene_producttnsubj [lemma='4e-bp1'] Gene_or_gene_productt#interceding-token ngrams: ) and p70t-e2: args2Role-mention-ngram: longer interactst0interceding-token ngrams: Upon phosphorylation ,t!e1: ents2Label-mention-ngram: 4E-tte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mtor'] Gene_or_gene_productt"interceding-token ngrams: ( 4E-BP1t interceding-token ngrams: p70 S6t]e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] Gene_or_gene_producttEe1: trigger-arg-path: phosphorylates >nsubj [lemma='mtor'] controllert&interceding-token ngrams: 4E-BP1 ) andtke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productte1: ents2Label-mention-ngram: :t(e1: ents2Label-mention-ngram: proteins :tinterceding-token ngrams: - )t/e1: ents2Label-mention-ngram: the translationaltJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtor'] controllert9e1: ents2Label-mention-ngram: activates the translationaltce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtor'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] Gene_or_gene_productt*e1: ents2Label-mention-ngram: : eukaryotictge2: trigger-arg-path: interacts >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] Gene_or_gene_productt`e2: trigger-arg-path: interacts:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] themet5e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT not'interceding-token ngrams: p70 S6 kinasete1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='mtor'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='mtor'] controller:Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='4e-bp1'] themet0e2: args2Role-mention-ngram: and represses THEMEtVe2: trigger-arg-path: Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] themet1e2: ents2Label-mention-ngram: no longer interactst2e2: args2Role-mention-ngram: longer interacts witht$e2: ents2Label-mention-ngram: longert%interceding-token ngrams: S6 kinase .t"interceding-token ngrams: 4E-BP1 )t'interceding-token ngrams: kinase . Upont3e1: ents2Label-mention-ngram: initiation factor 4E-t`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mtor'] Gene_or_gene_productt5e1: ents2Label-mention-ngram: translational machinerytke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='mtor'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='4e-bp1'] themet?e2: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] theme:Gene_or_gene_producttme2: trigger-arg-path: interacts >conj_and [lemma='repress'] >dobj [lemma='eif-4e'] theme:Gene_or_gene_producttne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='mtor'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: THEME no longert;e2: trigger-arg-path: Binding >nsubj [lemma='4e-bp1'] themet,e2: args2Role-mention-ngram: represses THEMEtRe2: trigger-arg-path: interacts >nsubj [lemma='4e-bp1'] theme:Gene_or_gene_productt2e2: args2Role-mention-ngram: to produce CONTROLLEDt1e2: args2Role-mention-ngram: occurring in musclest#interceding-token ngrams: ( ammoniat*e2: args2Role-mention-ngram: in muscles tot+interceding-token ngrams: , giving secretedt"e1: ents2Label-mention-ngram: somet5e2: ents2Label-mention-ngram: produce SIMPLE_CHEMICALtinterceding-token ngrams: NH3 (t5e2: ents2Label-mention-ngram: BIOPROCESS occurring intinterceding-token ngrams: poolstTe2: trigger-arg-path: produce:Positive_activation ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlled:FamilytJe2: trigger-arg-path: Positive_activation >dobj controlled:Simple_chemicalt)interceding-token ngrams: used by musclestMe1: trigger-arg-path: produces:Positive_activation >ccomp >prep_in controlledtse1: trigger-arg-path: produces:Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] Familyt[e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation dobj [lemma='glutamine'] controlledtme2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >dobj [lemma='glutamine'] Simple_chemicalt+e1: ents2Label-mention-ngram: produces sometxe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >dobj [lemma='glutamine'] controlled:Simple_chemicaltpe1: trigger-arg-path: lemmatizedTrigger=produce >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] Familyt2e2: ents2Label-mention-ngram: occurring in musclest%interceding-token ngrams: ( ammonia )t!e1: args2Role-mention-ngram: poolt'interceding-token ngrams: NH3 ( ammoniatRe2: trigger-arg-path: produce:Positive_activation >dobj controlled:Simple_chemicalt4e2: args2Role-mention-ngram: CONTROLLER occurring int2e1: args2Role-mention-ngram: CONTROLLED , producest'e2: args2Role-mention-ngram: in musclestoe2: trigger-arg-path: produce:Positive_activation nsubj [lemma='atp'] controller:Simple_chemicalt@e2: trigger-arg-path: produce nsubj [lemma='atp'] Simple_chemicalt*CSSPATH: ROOT  ++ ROOT >nsubj >vmod >xcompt#interceding-token ngrams: ammonia )t2e2: ents2Label-mention-ngram: BIOPROCESS occurringt"interceding-token ngrams: , givingtSe2: trigger-arg-path: Positive_activation >dobj [lemma='glutamine'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation ccomp >prep_in controlledt@e1: trigger-arg-path: produces >nsubj controller:Simple_chemicalt-e1: ents2Label-mention-ngram: of the pyruvatet*e1: args2Role-mention-ngram: pyruvate poolt&interceding-token ngrams: secreted NH3tIe1: trigger-arg-path: produces:Positive_activation >nsubj Simple_chemicaltAe1: trigger-arg-path: lemmatizedTrigger=produce >nsubj controllert[e2: trigger-arg-path: produce dobj [lemma='glutamine'] Simple_chemicalt+e2: ents2Label-mention-ngram: in muscles tot'e1: args2Role-mention-ngram: , producestKe1: trigger-arg-path: Positive_activation >ccomp >prep_in controlled:Familyt@e1: trigger-arg-path: produces >ccomp >prep_in controlled:FamilytYe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >dobj Simple_chemicalt0e2: ents2Label-mention-ngram: muscles to producetOe1: trigger-arg-path: lemmatizedTrigger=produce >nsubj [lemma='atp'] controllertfe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation ccomp >prep_in controlledt%e1: args2Role-mention-ngram: pyruvatet'interceding-token ngrams: by muscles totTe1: trigger-arg-path: lemmatizedTrigger=produce >nsubj [lemma='atp'] Simple_chemicalt/e1: ents2Label-mention-ngram: pyruvate pool andtIe2: trigger-arg-path: produce:Positive_activation dobj [lemma='glutamine'] controlledtee1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >nsubj controller:Simple_chemicalt(e2: ents2Label-mention-ngram: muscles tot&e1: ents2Label-mention-ngram: pyruvatetZe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >ccomp >prep_in Familyt_e1: trigger-arg-path: lemmatizedTrigger=produce >nsubj [lemma='atp'] controller:Simple_chemicalt1e1: ents2Label-mention-ngram: and SIMPLE_CHEMICALt(e1: ents2Label-mention-ngram: , producest interceding-token ngrams: ) usedt5e1: trigger-arg-path: produces >nsubj Simple_chemicalt)e1: ents2Label-mention-ngram: some of thete1: trigger: producestUe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >nsubj controllert)interceding-token ngrams: glutamine poolst'e2: args2Role-mention-ngram: muscles totQe1: trigger-arg-path: lemmatizedTrigger=produce >nsubj controller:Simple_chemicaltwe1: trigger-arg-path: produces:Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlledtNe1: trigger-arg-path: Positive_activation >nsubj [lemma='atp'] Simple_chemicalt1e2: args2Role-mention-ngram: CONTROLLER occurringt&e1: ents2Label-mention-ngram: FAMILY ,t,e1: args2Role-mention-ngram: , produces somet?e2: trigger-arg-path: Positive_activation >dobj Simple_chemicalt,interceding-token ngrams: build up glutaminetee1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >ccomp >prep_in controlled:FamilytGe2: trigger-arg-path: lemmatizedTrigger=produce ccomp [lemma='participate'] >prep_in [lemma='synthesis'] Familyt0e1: args2Role-mention-ngram: pool and CONTROLLERtinterceding-token ngrams: buildtfe2: trigger-arg-path: produce ccomp >prep_in controlled:Familyt5e2: trigger-arg-path: produce dobj controlledt>e2: trigger-arg-path: produce >dobj controlled:Simple_chemicalt/e1: ents2Label-mention-ngram: FAMILY , producest?e1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlledt!interceding-token ngrams: ammoniatIe1: trigger-arg-path: produces:Positive_activation >ccomp >prep_in Familytinterceding-token ngrams: NH3t6e1: ents2Label-mention-ngram: pool and SIMPLE_CHEMICALt3e2: trigger-arg-path: produce >dobj Simple_chemicalt&e1: ents2Label-mention-ngram: pool andt9e1: trigger-arg-path: produces >ccomp >prep_in controlledtne1: trigger-arg-path: Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlledt$interceding-token ngrams: by musclestIe2: trigger-arg-path: produce:Positive_activation nsubj [lemma='atp'] controller:Simple_chemicalt[e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlled:Familyt*e1: args2Role-mention-ngram: produces somet[e2: trigger-arg-path: produce:Positive_activation >dobj [lemma='glutamine'] Simple_chemicaltAe2: trigger-arg-path: Positive_activation dobj Simple_chemicalt.e1: ents2Label-mention-ngram: produces some oft"interceding-token ngrams: build upt%interceding-token ngrams: used by thetinterceding-tokens-full-span: , giving secreted NH3 ( ammonia ) used by muscles to build up glutamine pools used by the tumor .tBe2: trigger-arg-path: produce >dobj [lemma='glutamine'] controlledt^e2: trigger-arg-path: Positive_activation >dobj [lemma='glutamine'] controlled:Simple_chemicalt*interceding-token ngrams: muscles to buildtje1: trigger-arg-path: Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] Familyt"interceding-token ngrams: secretedt>e1: trigger-arg-path: produces >nsubj [lemma='atp'] controllert(e1: args2Role-mention-ngram: some of thetge2: trigger-arg-path: Positive_activation ccomp >prep_in FamilytPe2: trigger-arg-path: lemmatizedTrigger=produce >dobj controlled:Simple_chemicalthe2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >dobj [lemma='glutamine'] controlledtCe1: trigger-arg-path: produces >nsubj [lemma='atp'] Simple_chemicalt5e2: trigger-arg-path: produce nsubj Simple_chemicalt-e1: ents2Label-mention-ngram: , produces somet^e1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >ccomp >prep_in controlledtIe1: trigger-arg-path: Positive_activation >nsubj [lemma='atp'] controllertme2: trigger-arg-path: lemmatizedTrigger=produce dobj [lemma='glutamine'] controlled:Simple_chemicaltRe2: trigger-arg-path: lemmatizedTrigger=produce dobj [lemma='glutamine'] controlledtDe1: trigger-arg-path: produces:Positive_activation >nsubj controllertxe2: trigger-arg-path: lemmatizedTrigger=produce dobj [lemma='glutamine'] controlled:Simple_chemicalt-interceding-token ngrams: giving secreted NH3t+e1: ents2Label-mention-ngram: pyruvate poolt8e2: ents2Label-mention-ngram: to produce SIMPLE_CHEMICALt(interceding-token ngrams: secreted NH3 (t$e2: args2Role-mention-ngram: musclest~e1: trigger-arg-path: produces:Positive_activation >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlled:FamilytAe2: trigger-arg-path: Positive_activation nsubj [lemma='atp'] controller:Simple_chemicalt@e2: trigger-arg-path: lemmatizedTrigger=produce >dobj controlledt-e1: args2Role-mention-ngram: produces some oft0e1: trigger-arg-path: produces >nsubj controllert@e1: trigger-arg-path: Positive_activation >ccomp >prep_in Familythe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >nsubj [lemma='atp'] Simple_chemicalt.e1: args2Role-mention-ngram: pyruvate pool andt%interceding-token ngrams: the tumor .t$interceding-token ngrams: pools usedt$interceding-token ngrams: muscles totze2: trigger-arg-path: produce:Positive_activation ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlledt'interceding-token ngrams: pools used byt,e1: args2Role-mention-ngram: of the pyruvatet&e2: args2Role-mention-ngram: occurringt%e1: args2Role-mention-ngram: producest.interceding-token ngrams: glutamine pools usedt.e2: trigger-arg-path: produce >dobj controlledt&interceding-token ngrams: up glutaminetde2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >dobj controlled:Simple_chemicaltRe1: trigger-arg-path: produces:Positive_activation >nsubj [lemma='atp'] controllertce1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >nsubj [lemma='atp'] controllertTe1: trigger-arg-path: produces:Positive_activation >nsubj controller:Simple_chemicaltme2: trigger-arg-path: lemmatizedTrigger=produce ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlled:FamilytYe1: trigger-arg-path: Positive_activation >nsubj [lemma='atp'] controller:Simple_chemicalt[e2: trigger-arg-path: produce ccomp >prep_in controlled:Familyt?e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlled:Familyt#interceding-token ngrams: glutaminetce1: trigger-arg-path: produces >ccomp [lemma='participate'] >prep_in [lemma='synthesis'] controlledtGe2: trigger-arg-path: produce >dobj [lemma='glutamine'] Simple_chemicalt!interceding-token ngrams: used bytGe2: trigger-arg-path: produce:Positive_activation >dobj Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation ccomp [lemma='participate'] >prep_in [lemma='synthesis'] Familyt,interceding-token ngrams: up glutamine poolst)e1: args2Role-mention-ngram: the pyruvatet/e2: args2Role-mention-ngram: produce CONTROLLEDtZe1: trigger-arg-path: lemmatizedTrigger=produce:Positive_activation >nsubj Simple_chemicaltRe2: trigger-arg-path: produce >dobj [lemma='glutamine'] controlled:Simple_chemicaltinterceding-token ngrams: usedtBe2: trigger-arg-path: produce:Positive_activation >dobj controlledt"interceding-token ngrams: to buildt*e2: ents2Label-mention-ngram: occurring intFe1: trigger-arg-path: lemmatizedTrigger=produce >ccomp >prep_in Familyt$e2: ents2Label-mention-ngram: of AKTt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn Gene_or_gene_producttBe2: trigger-arg-path: Positive_regulation >conj_and >nn controllert*e1: ents2Label-mention-ngram: AKT , SHAREDtHe2: trigger-arg-path: phosphorylation >conj_and >nn Gene_or_gene_producttve2: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_productt!e1: ents2Label-mention-ngram: 2 ,tSe1: trigger-arg-path: phosphorylation >conj_and >nn controller:Gene_or_gene_productt4e1: ents2Label-mention-ngram: phosphorylation of AKTtue2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllertae1: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllertee2: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert>e2: trigger-arg-path: phosphorylation >conj_and >nn controllert*e2: ents2Label-mention-ngram: AKT , SHAREDt#e2: ents2Label-mention-ngram: AKT ,te2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: 2 , andtZe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn Gene_or_gene_producttWe2: trigger-arg-path: Positive_regulation >conj_and >nn controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: CONTROLLED and 2t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn controllerte1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_productt\e1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn Gene_or_gene_productt%e1: ents2Label-mention-ngram: 2 , andt$e1: args2Role-mention-ngram: 2 , andt\e2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn Gene_or_gene_producttae2: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert&e2: ents2Label-mention-ngram: of AKT ,t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert&e1: ents2Label-mention-ngram: of AKT ,tee1: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert$e2: args2Role-mention-ngram: 2 , andt}e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_producttze1: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_productt!e2: ents2Label-mention-ngram: 2 ,t%e2: ents2Label-mention-ngram: and 2 ,tLe2: trigger-arg-path: Positive_regulation >conj_and >nn Gene_or_gene_producttve1: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn controller:Gene_or_gene_producttge2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn Gene_or_gene_producttoe1: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_producttHe1: trigger-arg-path: phosphorylation >conj_and >nn Gene_or_gene_productt?e1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttLe1: trigger-arg-path: Positive_regulation >conj_and >nn Gene_or_gene_productt%e1: ents2Label-mention-ngram: and 2 ,t$e1: args2Role-mention-ngram: and 2 ,tde2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn controllertse1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllertoe2: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_productt-e1: args2Role-mention-ngram: CONTROLLED and 2t?e2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttge1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: , and CONTROLLERt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_producttSe2: trigger-arg-path: phosphorylation >conj_and >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllertye1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >conj_and >nn controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_productt e1: args2Role-mention-ngram: 2 ,t*e1: ents2Label-mention-ngram: SHARED and 2tke1: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_productt4e2: ents2Label-mention-ngram: phosphorylation of AKTtue1: trigger-arg-path: phosphorylation:Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controllert+e2: args2Role-mention-ngram: and CONTROLLERt e2: args2Role-mention-ngram: 2 ,tze2: trigger-arg-path: Positive_regulation >conj_and [lemma='activity'] >nn [lemma='ralum'] controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: and 2 ,t*e2: ents2Label-mention-ngram: , SHARED andtke2: trigger-arg-path: phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_productt}e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and [lemma='activity'] >nn [lemma='ralum'] Gene_or_gene_producttWe1: trigger-arg-path: Positive_regulation >conj_and >nn controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=phosphorylation >conj_and >nn controller:Gene_or_gene_productt#e1: ents2Label-mention-ngram: AKT ,t$e1: ents2Label-mention-ngram: of AKTtRe2: trigger-arg-path: phosphorylation:Positive_regulation >conj_and >nn controllert"interceding-token ngrams: to Bax ,t-interceding-token ngrams: thus modulating itst&interceding-token ngrams: kinase knownt3interceding-token ngrams: proapoptotic kinase knownt'interceding-token ngrams: known to bindt!interceding-token ngrams: to bindt$interceding-token ngrams: to bind tot%interceding-token ngrams: bind to Baxt(interceding-token ngrams: its activity .t!interceding-token ngrams: ( MOAP1tinterceding-token ngrams: Bax ,t1interceding-token ngrams: modulating its activityt+interceding-token ngrams: , thus modulatingt&interceding-token ngrams: its activityt(interceding-token ngrams: a proapoptotict interceding-token ngrams: to Baxt$interceding-token ngrams: modulatingt(interceding-token ngrams: modulating itst*interceding-token ngrams: , a proapoptotict/interceding-token ngrams: a proapoptotic kinaset)interceding-token ngrams: thus modulatingt#interceding-token ngrams: ( MOAP1 )t#interceding-token ngrams: 1 ( MOAP1t)interceding-token ngrams: kinase known tot#interceding-token ngrams: MOAP1 ) ,t-interceding-token ngrams: proapoptotic kinaset$interceding-token ngrams: Bax , thustinterceding-token ngrams: MOAP1t&interceding-token ngrams: proapoptotict!interceding-token ngrams: MOAP1 )t|interceding-tokens-full-span: 1 ( MOAP1 ) , a proapoptotic kinase known to bind to Bax , thus modulating its activity . Thist?interceding-tokens-full-span: inhibited the auto-phosphorylation and activation of c-Src and the related Src family tyrosine kinase Fyn . Theset)interceding-token ngrams: the related Srct)interceding-token ngrams: family tyrosinet-interceding-token ngrams: Src family tyrosinetinterceding-token ngrams: Fyn .t,interceding-token ngrams: related Src familyt.interceding-token ngrams: auto-phosphorylationt$interceding-token ngrams: kinase Fynt&interceding-token ngrams: of c-Src andt&interceding-token ngrams: kinase Fyn .t%interceding-token ngrams: Fyn . Theset'interceding-token ngrams: c-Src and thet%interceding-token ngrams: the relatedt2interceding-token ngrams: the auto-phosphorylationtinterceding-token ngrams: Fynt%interceding-token ngrams: related Srct6interceding-token ngrams: the auto-phosphorylation andt-interceding-token ngrams: tyrosine kinase Fynt#interceding-token ngrams: c-Src andt2e2: ents2Label-mention-ngram: N-terminus of SHAREDt=interceding-token ngrams: auto-phosphorylation and activationt2interceding-token ngrams: auto-phosphorylation andt)interceding-token ngrams: tyrosine kinaset0interceding-token ngrams: family tyrosine kinasetprep_of [lemma='shp2'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gab1'] Gene_or_gene_productt/interceding-token ngrams: stimulation of HEK293t/interceding-token ngrams: following stimulationt&interceding-token ngrams: HEK293 cellst;e1: trigger-arg-path: Binding >prep_of [lemma='pi3k'] themetde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] Gene_or_gene_productt&interceding-token ngrams: PI3K to IRS4t2interceding-token ngrams: co-stimulation increasedtde2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gab1'] themetinterceding-token ngrams: IRS4tme2: trigger-arg-path: complex nn [lemma='gab1'] themet(interceding-token ngrams: IRS protein intae2: trigger-arg-path: complex nn [lemma='gab1'] Gene_or_gene_productt,interceding-token ngrams: cells was measuredt9interceding-token ngrams: that insulin-EGF co-stimulationtje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt;e1: trigger-arg-path: binding >prep_of [lemma='shp2'] themet+interceding-token ngrams: data confirm thatt#interceding-token ngrams: to IRS4 (tUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] themetJe1: trigger-arg-path: Binding >prep_of [lemma='pi3k'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] themet\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] Gene_or_gene_productt%interceding-token ngrams: combinationt'interceding-token ngrams: combination .tge2: trigger-arg-path: Binding nn [lemma='gab1'] themet0interceding-token ngrams: by immunoprecipitationt(interceding-token ngrams: in these cellstje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gab1'] theme:Gene_or_gene_productt*interceding-token ngrams: that insulin-EGFt#interceding-token ngrams: , insulint&interceding-token ngrams: data confirmtPe1: trigger-arg-path: binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] Gene_or_gene_productt9interceding-token ngrams: measured by immunoprecipitationt6interceding-token ngrams: co-stimulation increased thet&interceding-token ngrams: was measuredt>interceding-token ngrams: insulin-EGF co-stimulation increasedt#interceding-token ngrams: of HEK293t3CSSPATH: ROOT >dobj >appos ++ ROOT >ccomp >dobj >nntRe1: trigger-arg-path: binding:Binding >prep_of [lemma='shp2'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] themetPe1: trigger-arg-path: binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt4interceding-token ngrams: insulin-EGF co-stimulationt-interceding-token ngrams: their combination .t'interceding-token ngrams: EGF , insulintinterceding-token ngrams: EGF ,tinterceding-tokens-full-span: to GAB1 and of PI3K to IRS4 ( the major IRS protein in these cells was measured by immunoprecipitation analysis following stimulation of HEK293 cells with EGF , insulin and their combination . The data confirm that insulin-EGF co-stimulation increased thet/interceding-token ngrams: and their combinationtue2: trigger-arg-path: complex:Binding prep_of [lemma='shp2'] Gene_or_gene_producttXe2: trigger-arg-path: complex nn [lemma='gab1'] Gene_or_gene_productt)interceding-token ngrams: these cells wastge2: trigger-arg-path: complex nn [lemma='gab1'] theme:Gene_or_gene_productt%interceding-token ngrams: insulin-EGFt6interceding-token ngrams: immunoprecipitation analysistge2: trigger-arg-path: Binding nn [lemma='gab1'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binding:Binding >prep_of [lemma='shp2'] themetRe2: trigger-arg-path: complex nn [lemma='gab1'] themet+interceding-token ngrams: insulin and theirt+interceding-token ngrams: combination . Thet%interceding-token ngrams: to GAB1 andt;e1: trigger-arg-path: binding >prep_of [lemma='pi3k'] themet!interceding-token ngrams: PI3K totoe2: trigger-arg-path: complex:Binding prep_of [lemma='pi3k'] Gene_or_gene_productt interceding-token ngrams: HEK293tme2: trigger-arg-path: Binding prep_of [lemma='shp2'] theme:Gene_or_gene_productt interceding-token ngrams: and oftXe2: trigger-arg-path: Binding prep_of [lemma='pi3k'] Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt*interceding-token ngrams: The data confirmt!interceding-token ngrams: to GAB1tbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt!interceding-token ngrams: to IRS4t'interceding-token ngrams: , insulin andt;e1: trigger-arg-path: Binding >prep_of [lemma='shp2'] themet{e2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gab1'] Gene_or_gene_productt@interceding-token ngrams: immunoprecipitation analysis followingt&interceding-token ngrams: confirm thattCe1: trigger-arg-path: binding:Binding >prep_of [lemma='pi3k'] themetPe1: trigger-arg-path: Binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt"interceding-token ngrams: in theset+interceding-token ngrams: HEK293 cells withtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='pi3k'] theme:Gene_or_gene_productt#interceding-token ngrams: and theirt`e2: trigger-arg-path: complex:Binding nn [lemma='gab1'] theme:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=complex prep_of [lemma='pi3k'] theme:Gene_or_gene_productt(interceding-token ngrams: co-stimulationt$interceding-token ngrams: IRS4 ( thet)interceding-token ngrams: of HEK293 cellstUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] themetinterceding-token ngrams: IRStye2: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='gab1'] Gene_or_gene_productt%interceding-token ngrams: IRS proteint$interceding-token ngrams: . The datatoe2: trigger-arg-path: complex:Binding nn [lemma='gab1'] theme:Gene_or_gene_productt'interceding-token ngrams: the major IRSt$interceding-token ngrams: protein int$interceding-token ngrams: with EGF ,t+interceding-token ngrams: major IRS proteintle2: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='gab1'] themet?e2: trigger-arg-path: lemmatizedTrigger=complex:Binding prep_between [lemma='nrf2'] themetee2: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_producttWe2: trigger-arg-path: interactions >prep_between [lemma='eralpha'] Gene_or_gene_productt)interceding-token ngrams: This inhibitiontpe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='nrf2'] Gene_or_gene_producttHe2: trigger-arg-path: interactions >prep_between [lemma='eralpha'] themetSe1: trigger-arg-path: inhibits >nsubj [lemma='estrogen'] controller:Simple_chemicaltje1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt/interceding-token ngrams: inhibition can resultt^e1: trigger-arg-path: Negative_activation >nsubj [lemma='estrogen'] controller:Simple_chemicaltwinterceding-tokens-full-span: activity , resulting in augmented genotoxicity . This inhibition can result from physicalt$interceding-token ngrams: can resultt`e1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlledt]e2: trigger-arg-path: interactions >prep_between [lemma='eralpha'] theme:Gene_or_gene_producttbe2: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_productt(interceding-token ngrams: genotoxicity .t\e1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='estrogen'] Simple_chemicaltOe2: trigger-arg-path: Binding >prep_between [lemma='nrf2'] Gene_or_gene_productt~e1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt-interceding-token ngrams: This inhibition cant%interceding-token ngrams: result fromt(interceding-token ngrams: inhibition cantXe2: trigger-arg-path: Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_producttUe2: trigger-arg-path: Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: Negative_activation >nsubj [lemma='estrogen'] Simple_chemicalt.interceding-token ngrams: result from physicaltPe2: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] themet#interceding-token ngrams: augmentedt&interceding-token ngrams: genotoxicitytke2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttse1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] Gene_or_gene_producttTe2: trigger-arg-path: interactions >prep_between [lemma='nrf2'] Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] themet\e2: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] Gene_or_gene_producttZe2: trigger-arg-path: interactions >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttCe2: trigger-arg-path: Binding >prep_between [lemma='eralpha'] themet1CSSPATH: ROOT >conj_and >ccomp ++ ROOT >prep_fromtne2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt)interceding-token ngrams: can result fromtje1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] Gene_or_gene_productt0interceding-token ngrams: resulting in augmentedtUe1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='nrf2'] controlledt{e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='nrf2'] controlled:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='estrogen'] controller:Simple_chemicaltNe1: trigger-arg-path: Negative_activation >nsubj [lemma='estrogen'] controllertVe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] themetue1: trigger-arg-path: Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlled:Gene_or_gene_productt0interceding-token ngrams: augmented genotoxicitytee2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='nrf2'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='estrogen'] controllertae2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] themetme2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] Gene_or_gene_producttie1: trigger-arg-path: inhibits:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlledtfe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activity'] >nn [lemma='nrf2'] controlledt&interceding-token ngrams: in augmentedtMe2: trigger-arg-path: interactions:Binding >prep_between [lemma='nrf2'] themetYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='estrogen'] Simple_chemicalthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='estrogen'] controllert@e2: trigger-arg-path: Binding >prep_between [lemma='nrf2'] themetse2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='estrogen'] Simple_chemicaltWe1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='estrogen'] controllert'interceding-token ngrams: from physicalt_e2: trigger-arg-path: interactions:Binding >prep_between [lemma='eralpha'] Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='eralpha'] Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] controlledt.interceding-token ngrams: activity , resultingtge1: trigger-arg-path: inhibits:Negative_activation >nsubj [lemma='estrogen'] controller:Simple_chemicalt_e1: trigger-arg-path: inhibits >dobj [lemma='activity'] >nn [lemma='nrf2'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='eralpha'] theme:Gene_or_gene_productt2interceding-token ngrams: augmented genotoxicity .tRe2: trigger-arg-path: Binding >prep_between [lemma='eralpha'] Gene_or_gene_producttHe1: trigger-arg-path: inhibits >nsubj [lemma='estrogen'] Simple_chemicalt-interceding-token ngrams: genotoxicity . Thist?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activity'] >nn [lemma='nrf2'] Gene_or_gene_productt3interceding-token ngrams: in augmented genotoxicityt^e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='nrf2'] themetCe1: trigger-arg-path: inhibits >nsubj [lemma='estrogen'] controllert+interceding-token ngrams: . This inhibitiontxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='estrogen'] controller:Simple_chemicalt>e1: trigger-arg-path: Positive_activation nn controlledt'interceding-token ngrams: of SUR-8 witht?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of controller:Gene_or_gene_productt$interceding-token ngrams: SUR-8 witht#interceding-token ngrams: target oftue1: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of controller:Gene_or_gene_producttnn Familyt9e1: ents2Label-mention-ngram: suppresses activated FAMILYt+interceding-token ngrams: a ternary complextbe1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn controlledt7e1-label: Positive_activation + e2-label: Generic_eventt#interceding-token ngrams: elegans .tee1: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of controllert\e1: trigger-arg-path: suppresses activated nn [lemma='ra'] Familytoe1: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of Gene_or_gene_producttinterceding-token ngrams: SUR-8t'interceding-token ngrams: The formationt?e1: trigger-arg-path: suppresses activated nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert#interceding-token ngrams: a ternarytUe1: trigger-arg-path: lemmatizedTrigger=suppress activate nn controlled:FamilytOe1: trigger-arg-path: suppresses activated:Positive_activation nn Familyt&interceding-token ngrams: signaling intnsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_productt)interceding-token ngrams: signaling in C.t?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] controlled:Familyt%interceding-token ngrams: a target oftie1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn controlled:Familyt.interceding-token ngrams: although the abilityt{e1: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] controlled:Familyt,interceding-token ngrams: ternary complex oftFCSSPATH: ROOT >advcl ++ ROOT >ccomp >advcl >nsubj >prep_of >vmod >dobjt(interceding-token ngrams: with activatedt?e1: trigger-arg-path: suppresses activated nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_productt*interceding-token ngrams: MCP110 to impairt$interceding-token ngrams: could alsot^e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn Familytpe1: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] Familytge1: trigger-arg-path: suppresses activated nn [lemma='ra'] controlled:Familytke1: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] Familyt(interceding-token ngrams: , although thetZe1: trigger-arg-path: suppresses activated:Positive_activation nn controlled:Familyt-interceding-token ngrams: activity , althoughtJe1: trigger-arg-path: lemmatizedTrigger=suppress activate nn Familyt$interceding-token ngrams: complex oft*interceding-token ngrams: target of MCP110t!interceding-token ngrams: also bet$interceding-token ngrams: that SUR-8t*interceding-token ngrams: SUR-8 could alsotQe1: trigger-arg-path: suppresses activated nsubj >prep_of controllertee1: trigger-arg-path: Positive_activation nsubj >prep_of controller:Gene_or_gene_productt#interceding-token ngrams: also be atinterceding-token ngrams: in C.t'interceding-token ngrams: in C. eleganst"interceding-token ngrams: a targett'interceding-token ngrams: could also bet)interceding-token ngrams: MCP110 activityt?e1: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllertoe1: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] controlledtje1: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of Gene_or_gene_productt'interceding-token ngrams: elegans . Thet?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert!interceding-token ngrams: eleganstinterceding-token ngrams: be atfe1: trigger-arg-path: Positive_activation nn [lemma='ra'] controlled:Familyt*interceding-token ngrams: and Raf suggestst~e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of Gene_or_gene_productt,interceding-token ngrams: mediated signalingtPe1: trigger-arg-path: Positive_activation nsubj >prep_of controllert%interceding-token ngrams: be a targett?e1: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert%interceding-token ngrams: the abilityt+interceding-token ngrams: Raf suggests thattFe1: trigger-arg-path: suppresses activated nn controlled:Familyte1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] Familyt#interceding-token ngrams: to impairt"interceding-token ngrams: of SUR-8t`e1: trigger-arg-path: suppresses activated nn [lemma='ra'] controlledt/interceding-token ngrams: mediated signaling intNe1: trigger-arg-path: lemmatizedTrigger=suppress activate nn controlledt'interceding-token ngrams: to impair thette1: trigger-arg-path: suppresses activated:Positive_activation nn [lemma='ra'] controlledt?e1: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt?interceding-tokens-full-span: mediated signaling in C. elegans . The formation of a ternary complex of SUR-8 with activated Ras and Raf suggests that SUR-8 could also be a target of MCP110 activity , although the ability of MCP110 to impair thet&interceding-token ngrams: C. elegans .t(interceding-token ngrams: formation of at(interceding-token ngrams: the ability oft!e1: trigger: suppresses activatedt'interceding-token ngrams: activated Rast2e1: ents2Label-mention-ngram: suppresses activatedt?e1: trigger-arg-path: suppresses activated nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt)interceding-token ngrams: . The formationtGe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppresses activatedt?e1: trigger-arg-path: suppresses activated nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controllert&interceding-token ngrams: of a ternaryt$interceding-token ngrams: impair thetfe1: trigger-arg-path: suppresses activated nsubj >prep_of controller:Gene_or_gene_productt,interceding-token ngrams: of MCP110 activitytZe1: trigger-arg-path: Positive_activation nsubj >prep_of Gene_or_gene_productt?e1: trigger-arg-path: suppresses activated:Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_producttinterceding-token ngrams: C.tze1: trigger-arg-path: suppresses activated:Positive_activation nsubj >prep_of controller:Gene_or_gene_productt[e1: trigger-arg-path: Positive_activation nn [lemma='ra'] Familyt[e1: trigger-arg-path: suppresses activated nsubj >prep_of Gene_or_gene_productt.interceding-token ngrams: SUR-8 with activatedt;e1: trigger-arg-path: suppresses activated nn Familyt?e1: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt&interceding-token ngrams: although thet_e1: trigger-arg-path: Positive_activation nn [lemma='ra'] controlledt-interceding-token ngrams: suggests that SUR-8t?e1: trigger-arg-path: Positive_activation nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nsubj >prep_of controllert+interceding-token ngrams: MCP110 activity ,t$interceding-token ngrams: C. eleganstSe1: trigger-arg-path: suppresses activated:Positive_activation nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj [lemma='reduction'] >prep_of [lemma='sur-8'] Gene_or_gene_productt,interceding-token ngrams: with activated Rast&interceding-token ngrams: Raf suggeststve1: trigger-arg-path: lemmatizedTrigger=suppress activate nn [lemma='ra'] controlled:Familyt2e1: args2Role-mention-ngram: CONTROLLER suppressest=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppressest`e1: trigger-arg-path: lemmatizedTrigger=suppress activate nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=suppress activate:Positive_activation nn [lemma='ra'] controlledt*interceding-token ngrams: complex of SUR-8tEe1: trigger-arg-path: Positive_activation nn controlled:Familyt*interceding-token ngrams: that SUR-8 couldt1e1: args2Role-mention-ngram: suppresses activatedt/e1: args2Role-mention-ngram: interacts with Raft?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controller:Gene_or_gene_productt^e2: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controllert/e1: args2Role-mention-ngram: Raf and CONTROLLEDt.e1: ents2Label-mention-ngram: SHARED at Ser259t$e1: ents2Label-mention-ngram: Ser259t0e1: ents2Label-mention-ngram: interacts with Raft?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: at Ser259t?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controller:Gene_or_gene_producttle2: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controllertbe2: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controllert)e1: args2Role-mention-ngram: with Raf andt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controller:Gene_or_gene_productt-interceding-tokens-full-span: . Furthermore ,the2: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] Gene_or_gene_productt%e1: args2Role-mention-ngram: with Raft&e1: ents2Label-mention-ngram: with Raftze2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] Gene_or_gene_productt|e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] Gene_or_gene_producttre2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controllert4e1: ents2Label-mention-ngram: Raf and phosphorylatest&CSSPATH: ROOT >conj_and ++ ROOT >nsubjtwe2: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controller:Gene_or_gene_producttse2: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controller:Gene_or_gene_productt*e1: ents2Label-mention-ngram: with Raf andtpe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='akt'] controllertIe1: trigger-arg-path: interacts >nsubj [lemma='akt'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] themetce1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] Generic_entityt^e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] SitetOe1: trigger-arg-path: interacts >nsubj [lemma='akt'] theme:Gene_or_gene_producttke1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] Generic_entityt?e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] theme:Generic_entitytme1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] site:Sitet`e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] sitetqe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] sitetie1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] theme:Generic_entityt8e1: trigger-arg-path: Binding >nsubj [lemma='akt'] themethe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] Sitet~e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] site:Sitet*e1: args2Role-mention-ngram: THEME at SITEtFe1: trigger-arg-path: interacts:Binding >conj_and >dobj Generic_entitythe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='akt'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] Sitet|e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] Generic_entitytye1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] sitet`e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='akt'] theme:Gene_or_gene_productt>e1: trigger-arg-path: interacts >conj_and >dobj Generic_entitytge1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] theme:Generic_entitytbe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] themetae1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] Generic_entityt`e1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] SitetUe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj theme:Generic_entitytze1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] theme:Generic_entitytSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='akt'] themetee1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] site:SitetWe1: trigger-arg-path: interacts:Binding >nsubj [lemma='akt'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='akt'] Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='akt'] Gene_or_gene_productt^e1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] sitetDe1: trigger-arg-path: interacts >conj_and >dobj theme:Generic_entitytke1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] themetLe1: trigger-arg-path: interacts:Binding >conj_and >dobj theme:Generic_entityt:e1: trigger-arg-path: interacts >nsubj [lemma='akt'] themet3e1: args2Role-mention-ngram: Raf and phosphorylatestBe1: trigger-arg-path: Binding >conj_and >dobj theme:Generic_entityt]e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj theme:Generic_entitytKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='akt'] themette1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] Generic_entityt$e1: args2Role-mention-ngram: at SITEtGe1: trigger-arg-path: Binding >nsubj [lemma='akt'] Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=interact >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] site:SitetZe1: trigger-arg-path: interacts >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] themetMe1: trigger-arg-path: Binding >nsubj [lemma='akt'] theme:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] Sitethe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] sitetQe1: trigger-arg-path: interacts:Binding >nsubj [lemma='akt'] Gene_or_gene_producttqe1: trigger-arg-path: interacts:Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] theme:Generic_entitytconj_and >dobj Generic_entitytOe1: trigger-arg-path: lemmatizedTrigger=interact >conj_and >dobj Generic_entitytWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >conj_and >dobj Generic_entitytBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='akt'] themetXe1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >dobj [lemma='it'] themetce1: trigger-arg-path: Binding >conj_and [lemma='phosphorylate'] >prep_at [lemma='ser259'] site:Sitetinterceding-token ngrams: versat#interceding-token ngrams: this , int,interceding-token ngrams: antibodies againstt%interceding-token ngrams: for some oft#interceding-token ngrams: least fort`e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='cjun'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='cjun'] themetRe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of theme:Simple_chemicaltTe1: trigger-arg-path: interaction >prep_of [lemma='cjun'] theme:Gene_or_gene_productt!interceding-token ngrams: some oft%interceding-token ngrams: some of thet0CSSPATH: ROOT >nsubj ++ ROOT >xcomp >vmod >ccompt2e1: args2Role-mention-ngram: transcription factorst;e2: trigger-arg-path: Binding >prep_to [lemma='cjun'] themetPe2: trigger-arg-path: binds:Binding >prep_to [lemma='cjun'] Gene_or_gene_productt#interceding-token ngrams: were ablet/interceding-token ngrams: general mechanism fort$interceding-token ngrams: genes . Intne1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='cjun'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >prep_of [lemma='cjun'] theme:Gene_or_gene_productt?e1: trigger-arg-path: interaction >prep_of [lemma='cjun'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hif-1alpha'] Gene_or_gene_productt$interceding-token ngrams: studies wetLe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of Simple_chemicalt"interceding-token ngrams: for somet-interceding-token ngrams: HIF-1alpha might bet)interceding-token ngrams: with antibodiest&interceding-token ngrams: we were ablet&interceding-token ngrams: against cJuntEe1: trigger-arg-path: interaction >prep_of theme:Gene_or_gene_productt4interceding-token ngrams: HIF-1alpha with antibodiest*e1: args2Role-mention-ngram: factors THEMEt?e2: trigger-arg-path: Binding >nsubj [lemma='hif-1alpha'] themet&interceding-token ngrams: vice versa ,t*interceding-token ngrams: against cJun andtinterceding-token ngrams: linet$interceding-token ngrams: might be atBe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of themet9e1: trigger-arg-path: Binding >prep_of [lemma='ap'] themetQe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hif-1alpha'] theme:Gene_or_gene_productt"interceding-token ngrams: and vicetinterceding-token ngrams: vicet/e1: args2Role-mention-ngram: both transcriptiontWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of theme:Gene_or_gene_producttGe1: trigger-arg-path: interaction:Binding >prep_of Gene_or_gene_productt)interceding-token ngrams: HIF-1alpha witht-interceding-token ngrams: a general mechanismt0e1: ents2Label-mention-ngram: factors SHARED andtOe1: trigger-arg-path: interaction:Binding >prep_of [lemma='ap'] Simple_chemicaltge1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ap'] theme:Simple_chemicaltEe2: trigger-arg-path: binds:Binding >nsubj [lemma='hif-1alpha'] themet=e1: trigger-arg-path: interaction >prep_of [lemma='ap'] themetYe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ap'] Simple_chemicalt#interceding-token ngrams: the knowntNe2: trigger-arg-path: binds >prep_to [lemma='cjun'] theme:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ap'] Simple_chemicaltke2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hif-1alpha'] theme:Gene_or_gene_productt8interceding-token ngrams: immunoprecipitation studies wet,interceding-token ngrams: for the regulationt0e1: trigger-arg-path: interaction >prep_of themetprep_of theme:Simple_chemicalt+interceding-token ngrams: inducible genes .tOe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ap'] themet(interceding-token ngrams: the regulationtNe2: trigger-arg-path: Binding >nsubj [lemma='hif-1alpha'] Gene_or_gene_productt!interceding-token ngrams: In linet8e1: args2Role-mention-ngram: transcription factors THEMEt\e1: trigger-arg-path: interaction:Binding >prep_of [lemma='cjun'] theme:Gene_or_gene_producttRe2: trigger-arg-path: binds >nsubj [lemma='hif-1alpha'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hif-1alpha'] Gene_or_gene_producttPe2: trigger-arg-path: Binding >prep_to [lemma='cjun'] theme:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of themet_e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='ap'] theme:Simple_chemicalt1interceding-token ngrams: to co-immunoprecipitatetHe2: trigger-arg-path: binds >prep_to [lemma='cjun'] Gene_or_gene_productt!interceding-token ngrams: we weretfe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='cjun'] theme:Gene_or_gene_productt!interceding-token ngrams: generaltRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cjun'] themet6interceding-token ngrams: able to co-immunoprecipitatet(interceding-token ngrams: and HIF-1alphatIe1: trigger-arg-path: Binding >prep_of [lemma='ap'] theme:Simple_chemicaltAe2: trigger-arg-path: binds:Binding >prep_to [lemma='cjun'] themet+e1: args2Role-mention-ngram: interaction oft interceding-token ngrams: -1 andthe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='cjun'] Gene_or_gene_productt&interceding-token ngrams: at least fort6e1: trigger-arg-path: Binding >prep_of Simple_chemicaltQe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_of [lemma='cjun'] themetNe1: trigger-arg-path: interaction >prep_of [lemma='cjun'] Gene_or_gene_producttVe1: trigger-arg-path: interaction:Binding >prep_of [lemma='cjun'] Gene_or_gene_productt1interceding-token ngrams: with antibodies againstt0e1: ents2Label-mention-ngram: both transcriptiont+interceding-token ngrams: hypoxia induciblet#interceding-token ngrams: a generalt.interceding-token ngrams: co-immunoprecipitatet,e1: ents2Label-mention-ngram: factors SHAREDt7e1: args2Role-mention-ngram: both transcription factorstJe2: trigger-arg-path: Binding >prep_to [lemma='cjun'] Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of Simple_chemicalt&interceding-token ngrams: In line withtMe1: trigger-arg-path: interaction >prep_of [lemma='ap'] theme:Simple_chemicalt"interceding-token ngrams: might bet8interceding-token ngrams: in immunoprecipitation studiest1e1: ents2Label-mention-ngram: interaction of botht.e1: args2Role-mention-ngram: factors THEME andt)interceding-token ngrams: studies we weretJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cjun'] themet(interceding-token ngrams: and vice versat+interceding-token ngrams: mechanism for thetZe2: trigger-arg-path: binds:Binding >nsubj [lemma='hif-1alpha'] theme:Gene_or_gene_productt5interceding-token ngrams: immunoprecipitation studiest8e1: ents2Label-mention-ngram: both transcription factorst0interceding-token ngrams: in immunoprecipitationt$interceding-token ngrams: HIF-1alphatUe1: trigger-arg-path: interaction:Binding >prep_of [lemma='ap'] theme:Simple_chemicalt1interceding-token ngrams: hypoxia inducible genest1interceding-token ngrams: known hypoxia induciblet,interceding-token ngrams: versa , indicatingtGe1: trigger-arg-path: interaction:Binding >prep_of [lemma='cjun'] themetVe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hif-1alpha'] themetprep_of [lemma='cjun'] Gene_or_gene_productt+interceding-token ngrams: -1 and HIF-1alphat0e1: args2Role-mention-ngram: interaction of botht1interceding-token ngrams: antibodies against cJunt_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of theme:Gene_or_gene_productt+interceding-token ngrams: the known hypoxiatGe1: trigger-arg-path: interaction >prep_of [lemma='ap'] Simple_chemicalt(interceding-token ngrams: least for sometLe2: trigger-arg-path: binds >nsubj [lemma='hif-1alpha'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cjun'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: of both transcriptiont?e1: trigger-arg-path: interaction >prep_of Gene_or_gene_producttTe2: trigger-arg-path: Binding >nsubj [lemma='hif-1alpha'] theme:Gene_or_gene_productt=e2: trigger-arg-path: binds >nsubj [lemma='hif-1alpha'] themet8e1: ents2Label-mention-ngram: SHARED and SIMPLE_CHEMICALt:e1: ents2Label-mention-ngram: transcription factors SHAREDtEe1: trigger-arg-path: interaction:Binding >prep_of [lemma='ap'] themet$interceding-token ngrams: vice versatBe1: trigger-arg-path: interaction:Binding >prep_of Simple_chemicalt9interceding-token ngrams: co-immunoprecipitate HIF-1alphatVe2: trigger-arg-path: binds:Binding >prep_to [lemma='cjun'] theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of [lemma='ap'] themet!interceding-token ngrams: hypoxiat.interceding-token ngrams: and HIF-1alpha mighttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cjun'] theme:Gene_or_gene_productt#interceding-token ngrams: line witht;e1: trigger-arg-path: Binding >prep_of [lemma='cjun'] themet9interceding-tokens-full-span: -1 and HIF-1alpha might be a general mechanism for the regulation at least for some of the known hypoxia inducible genes . In line with this , in immunoprecipitation studies we were able to co-immunoprecipitate HIF-1alpha with antibodies against cJun and vice versa , indicating thattYe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cjun'] theme:Gene_or_gene_productt!interceding-token ngrams: versa ,t&interceding-token ngrams: were able tot&interceding-token ngrams: of the knowntinterceding-token ngrams: cJuntTe2: trigger-arg-path: binds:Binding >nsubj [lemma='hif-1alpha'] Gene_or_gene_productt&interceding-token ngrams: be a generalt9e2: trigger-arg-path: binds >prep_to [lemma='cjun'] themet'interceding-token ngrams: cJun and vicet(interceding-token ngrams: line with thistNe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hif-1alpha'] themet2interceding-token ngrams: , in immunoprecipitationt#interceding-token ngrams: . In linetMe1: trigger-arg-path: interaction:Binding >prep_of theme:Gene_or_gene_productt$interceding-token ngrams: antibodiestHe1: trigger-arg-path: interaction:Binding >prep_of theme:Simple_chemicalt>interceding-token ngrams: co-immunoprecipitate HIF-1alpha witht*interceding-token ngrams: HIF-1alpha mightt3e1: ents2Label-mention-ngram: transcription factorst:e1: trigger-arg-path: interaction >prep_of Simple_chemicalt@e1: trigger-arg-path: interaction >prep_of theme:Simple_chemicalt'interceding-token ngrams: known hypoxiatCe1: trigger-arg-path: Binding >prep_of [lemma='ap'] Simple_chemicalt8e1: trigger-arg-path: interaction:Binding >prep_of themetYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cjun'] Gene_or_gene_productt"interceding-token ngrams: cJun andt+interceding-token ngrams: general mechanismtZe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_of theme:Simple_chemicalt*e2: ents2Label-mention-ngram: recruited tot.e2: ents2Label-mention-ngram: endosomes duringt,e1: ents2Label-mention-ngram: SHARED and Shct]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] theme:Gene_or_gene_producttMe1: trigger-arg-path: bind:Binding >nsubj [lemma='grb2'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_regulation >agent [lemma='egf'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: to endosomes duringtSe2: trigger-arg-path: recruited:Positive_regulation >agent [lemma='egf'] controllertFe2: trigger-arg-path: recruited >agent controller:Gene_or_gene_productt/interceding-token ngrams: residues and functiontYe2: trigger-arg-path: lemmatizedTrigger=recruit >agent [lemma='egf'] Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >agent [lemma='egf'] Gene_or_gene_productt2interceding-token ngrams: phosphotyrosine residuest&e1: ents2Label-mention-ngram: Shc bindtOe2: trigger-arg-path: lemmatizedTrigger=recruit >agent [lemma='egf'] controllert6interceding-token ngrams: phosphotyrosine residues andt:e2: ents2Label-mention-ngram: endosomes during stimulationtSe1: trigger-arg-path: bind:Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: are recruited totVe2: trigger-arg-path: lemmatizedTrigger=recruit >agent controller:Gene_or_gene_productt2e2: args2Role-mention-ngram: during stimulation byt)e1: ents2Label-mention-ngram: Shc bind totEe1: trigger-arg-path: bind >nsubj [lemma='grb2'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: stimulation by GENE_OR_GENE_PRODUCTt!e1: ents2Label-mention-ngram: ShctWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] Gene_or_gene_productt'interceding-token ngrams: of downstreamtIe2: trigger-arg-path: Positive_regulation >agent [lemma='egf'] controllert_e2: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >agent Gene_or_gene_producttNe1: trigger-arg-path: Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: bind to activatedt&interceding-token ngrams: and functiont*e1: ents2Label-mention-ngram: to activatedt*e1: args2Role-mention-ngram: THEME and Shct.interceding-token ngrams: downstream signalingtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] themetGe1: trigger-arg-path: bind >prep_to [lemma='egfr'] Gene_or_gene_productt0interceding-token ngrams: downstream signaling .tOe2: trigger-arg-path: recruited:Positive_regulation >agent Gene_or_gene_productt%interceding-token ngrams: as adaptorst8interceding-token ngrams: their phosphotyrosine residuest.e2: args2Role-mention-ngram: CONTROLLED duringtZe2: trigger-arg-path: recruited:Positive_regulation >agent controller:Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: and Shc bindt(e1: args2Role-mention-ngram: Shc bind tot(interceding-token ngrams: as adaptors oft?e2: trigger-arg-path: recruited >agent [lemma='egf'] controllertTe2: trigger-arg-path: recruited >agent [lemma='egf'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=recruit >agent [lemma='egf'] controller:Gene_or_gene_productt/interceding-token ngrams: their phosphotyrosinet3interceding-token ngrams: via their phosphotyrosinet&interceding-token ngrams: residues andt4e2: ents2Label-mention-ngram: recruited to endosomestOe1: trigger-arg-path: bind:Binding >prep_to [lemma='egfr'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: to endosomestAe2: trigger-arg-path: lemmatizedTrigger=recruit >agent controllert3e2: ents2Label-mention-ngram: during stimulation bytKe1: trigger-arg-path: bind >nsubj [lemma='grb2'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: recruitedt)interceding-token ngrams: and function ast0e2: ents2Label-mention-ngram: during stimulationt,e2: ents2Label-mention-ngram: stimulation byt"interceding-token ngrams: adaptorst+e2: args2Role-mention-ngram: stimulation byt$e1: args2Role-mention-ngram: and ShctHe1: trigger-arg-path: Binding >nsubj [lemma='grb2'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: duringt+e2: ents2Label-mention-ngram: are recruitedt?e1: ents2Label-mention-ngram: to activated GENE_OR_GENE_PRODUCTt]e2: trigger-arg-path: recruited:Positive_regulation >agent [lemma='egf'] Gene_or_gene_productt/e2: args2Role-mention-ngram: during stimulationte2: trigger: recruitedt@e1: trigger-arg-path: bind:Binding >prep_to [lemma='egfr'] themetje2: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >agent controller:Gene_or_gene_productt%e1: ents2Label-mention-ngram: and Shct1e2: trigger-arg-path: recruited >agent controllert:e2: args2Role-mention-ngram: CONTROLLED during stimulationthe2: trigger-arg-path: recruited:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_producttsinterceding-tokens-full-span: via their phosphotyrosine residues and function as adaptors of downstream signaling .tUe2: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >agent controllertUe1: trigger-arg-path: bind:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt2e2: ents2Label-mention-ngram: SHARED are recruitedt e1: args2Role-mention-ngram: Shct>e1: trigger-arg-path: bind:Binding >nsubj [lemma='grb2'] themet/e1: args2Role-mention-ngram: to activated THEMEt(e2: ents2Label-mention-ngram: SHARED aretMe1: trigger-arg-path: bind >prep_to [lemma='egfr'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] themet.e1: args2Role-mention-ngram: bind to activatedt%interceding-token ngrams: adaptors oft*e1: ents2Label-mention-ngram: and Shc bindt6e2: args2Role-mention-ngram: stimulation by CONTROLLERt;e2: trigger-arg-path: recruited >agent Gene_or_gene_productt)e1: args2Role-mention-ngram: to activatedt#e2: args2Role-mention-ngram: duringt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] Gene_or_gene_productt1interceding-token ngrams: of downstream signalingtxe2: trigger-arg-path: lemmatizedTrigger=recruit:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj [lemma='grb2'] themetee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=recruit >agent Gene_or_gene_producttagent [lemma='egf'] controllert%e1: args2Role-mention-ngram: Shc bindt8e1: trigger-arg-path: bind >prep_to [lemma='egfr'] themetIe2: trigger-arg-path: recruited >agent [lemma='egf'] Gene_or_gene_productt.interceding-token ngrams: function as adaptorstEe2: trigger-arg-path: recruited:Positive_regulation >agent controllert9e1: trigger-arg-path: Binding >nsubj [lemma='grb2'] themet0interceding-token ngrams: adaptors of downstreamt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='shc'] controllertee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controllertPe2: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] Gene_or_gene_producttAe2: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] themetOe1: trigger-arg-path: Positive_activation nsubj controllert/e2: args2Role-mention-ngram: to activated THEMEt?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='shc'] Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='egfr'] themet?e1: trigger-arg-path: Positive_activation nsubj [lemma='shc'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controller:Gene_or_gene_producttAe1: trigger-arg-path: lemmatizedTrigger=activate nsubj controllertVe2: trigger-arg-path: binds:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='egfr'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: CONTROLLER binds totge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_producttIe1: trigger-arg-path: Positive_activation nsubj [lemma='shc'] theme:Gene_or_gene_productt?e1: trigger-arg-path: Positive_activation nsubj [lemma='shc'] controller:Gene_or_gene_producttMe2: trigger-arg-path: binds:Binding >nsubj [lemma='shc'] Gene_or_gene_producttJe1: trigger-arg-path: activated nsubj Gene_or_gene_producttHe2: trigger-arg-path: binds >prep_to [lemma='egfr'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=activate nsubj Gene_or_gene_producttve1: trigger-arg-path: Positive_activation nsubj [lemma='shc'] controllert>e2: trigger-arg-path: binds:Binding >nsubj [lemma='shc'] themet?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='shc'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: binds to activatedtIe1: trigger-arg-path: activated nsubj [lemma='shc'] theme:Gene_or_gene_producttYtrigger-to-trigger-path: e1:activated:Positive_activation prep_to [lemma='egfr'] themetde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controllertJe2: trigger-arg-path: Binding >prep_to [lemma='egfr'] Gene_or_gene_productt]e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] controller:Gene_or_gene_producttNe1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] themetve1: trigger-arg-path: activated nsubj [lemma='shc'] Gene_or_gene_productt4e1: args2Role-mention-ngram: to activated CONTROLLEDt^e1: trigger-arg-path: activated:Positive_activation nsubj Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='shc'] themetye1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation prep_to [lemma='egfr'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >nsubj [lemma='shc'] theme:Gene_or_gene_producttEe2: trigger-arg-path: binds >nsubj [lemma='shc'] Gene_or_gene_producttSe1: trigger-arg-path: Positive_activation prep_to [lemma='egfr'] themet?e1: trigger-arg-path: activated nsubj [lemma='shc'] themetTe1: trigger-arg-path: activated prep_to [lemma='egfr'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] Gene_or_gene_producttNe2: trigger-arg-path: binds >prep_to [lemma='egfr'] theme:Gene_or_gene_producttYe1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj Gene_or_gene_productt?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] Gene_or_gene_productt_e1: trigger-arg-path: Positive_activation nsubj controller:Gene_or_gene_producttGe2: trigger-arg-path: Binding >nsubj [lemma='shc'] Gene_or_gene_productt6e2: trigger-arg-path: binds >nsubj [lemma='shc'] themet^e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='shc'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='shc'] controllert?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] controllert}e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='shc'] controllerthe1: trigger-arg-path: activated:Positive_activation nsubj controllertRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='egfr'] themet:e1: trigger-arg-path: activated nsubj [lemma='shc'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: binds to activatedt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='shc'] controller:Gene_or_gene_producttze1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=activate nsubj controller:Gene_or_gene_producttTe1: trigger-arg-path: Positive_activation nsubj Gene_or_gene_producttUe1: trigger-arg-path: activated nsubj controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='shc'] Gene_or_gene_producttSe1: trigger-arg-path: activated:Positive_activation nsubj [lemma='shc'] theme:Gene_or_gene_producttNe2: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] Gene_or_gene_producttFe1: trigger-arg-path: binds >nsubj [lemma='grb2'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='grb2'] themet?e2: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] themetHe2: trigger-arg-path: Binding >nsubj [lemma='grb2'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='grb2'] Gene_or_gene_producttFe2: trigger-arg-path: binds >nsubj [lemma='grb2'] Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] themet7e2: trigger-arg-path: binds >nsubj [lemma='grb2'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='grb2'] Gene_or_gene_productt7e1: trigger-arg-path: binds >nsubj [lemma='grb2'] themetLe2: trigger-arg-path: binds >nsubj [lemma='grb2'] theme:Gene_or_gene_producttNe1: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] Gene_or_gene_producttLe1: trigger-arg-path: binds >nsubj [lemma='grb2'] theme:Gene_or_gene_productt?e1: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] themetTe1: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >nsubj [lemma='grb2'] theme:Gene_or_gene_producttme2: trigger-arg-path: activated nsubj [lemma='gab1'] controllert=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also bindst*interceding-token ngrams: activated EGFR .tJe2: trigger-arg-path: Positive_activation nsubj controllert?e2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] controller:Gene_or_gene_productt interceding-token ngrams: EGFR .tJe2: trigger-arg-path: activated nsubj Gene_or_gene_producttTe2: trigger-arg-path: activated:Positive_activation nsubj controllertUe2: trigger-arg-path: activated nsubj controller:Gene_or_gene_productt?e2: trigger-arg-path: activated nsubj [lemma='gab1'] controllertye2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] Gene_or_gene_productt^e2: trigger-arg-path: activated:Positive_activation nsubj Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=activate nsubj controllert$interceding-token ngrams: or via Shctde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] controllert,interceding-token ngrams: either directly ort?e2: trigger-arg-path: activated nsubj [lemma='gab1'] controller:Gene_or_gene_productt)interceding-token ngrams: either directlyt_e2: trigger-arg-path: Positive_activation nsubj controller:Gene_or_gene_producttie2: trigger-arg-path: activated:Positive_activation nsubj controller:Gene_or_gene_productt%interceding-token ngrams: directly ortze2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controller:Gene_or_gene_producttSe2: trigger-arg-path: activated:Positive_activation nsubj Gene_or_gene_productt2e2: args2Role-mention-ngram: CONTROLLER also bindst&interceding-token ngrams: Shc bound tot interceding-token ngrams: or viat,interceding-token ngrams: bound to activatedtfe2: trigger-arg-path: lemmatizedTrigger=activate nsubj controller:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj controllert%CSSPATH: ROOT  ++ ROOT >prep_to >amodt'interceding-token ngrams: via Shc boundt?e2: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] Gene_or_gene_productt]e2: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] controllert+interceding-token ngrams: to activated EGFRtoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj Gene_or_gene_producttTe2: trigger-arg-path: activated nsubj Gene_or_gene_productt@e2: trigger-arg-path: activated nsubj controllert?e2: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] controllert?e2: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt4e2: args2Role-mention-ngram: to activated CONTROLLEDt?e2: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_producttinterceding-token ngrams: Shct(interceding-token ngrams: activated EGFRtHe1: trigger-arg-path: Binding >nsubj [lemma='gab1'] Gene_or_gene_productt$e2: ents2Label-mention-ngram: or viat/e2: args2Role-mention-ngram: either directly ortTe2: trigger-arg-path: bound:Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: or via Grb2t7e1: trigger-arg-path: binds >nsubj [lemma='gab1'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] Gene_or_gene_producttNe2: trigger-arg-path: bound:Binding >nsubj [lemma='gab1'] Gene_or_gene_productt/e2: args2Role-mention-ngram: bound to activatedt+e2: ents2Label-mention-ngram: Grb2 bound totHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] themet-e2: ents2Label-mention-ngram: either directlytDtrigger-to-trigger-path: e1:binds:Binding >conj_and e2:bound:Bindingt'e2: args2Role-mention-ngram: Grb2 boundt0e2: ents2Label-mention-ngram: either directly ort0e2: ents2Label-mention-ngram: bound to activatedt?e1: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] themet9e1: trigger-arg-path: Binding >nsubj [lemma='gab1'] themet1e2: args2Role-mention-ngram: EGFR either directlytNe1: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: activated EGFR eithert,e2: ents2Label-mention-ngram: activated EGFRt,e2: args2Role-mention-ngram: either directlyt(e2: ents2Label-mention-ngram: Grb2 boundt2e2: ents2Label-mention-ngram: EGFR either directlyt?e2: trigger-arg-path: bound:Binding >nsubj [lemma='gab1'] themet#e2: args2Role-mention-ngram: or viat!e2: args2Role-mention-ngram: Grb2t_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] Gene_or_gene_productt,e2: args2Role-mention-ngram: directly or viat)e2: ents2Label-mention-ngram: directly ortee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_producttFe1: trigger-arg-path: binds >nsubj [lemma='gab1'] Gene_or_gene_productt.e2: args2Role-mention-ngram: to activated EGFRt+e2: args2Role-mention-ngram: activated EGFRt,e2: ents2Label-mention-ngram: via Grb2 boundt!e2: args2Role-mention-ngram: EGFRt9e2: trigger-arg-path: Binding >nsubj [lemma='gab1'] themetTe1: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: bound >prep_to [lemma='egfr'] theme:Gene_or_gene_producttLe1: trigger-arg-path: binds >nsubj [lemma='gab1'] theme:Gene_or_gene_productt+e2: args2Role-mention-ngram: via Grb2 boundtLe2: trigger-arg-path: bound >nsubj [lemma='gab1'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: via Grb2tPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] themet]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] theme:Gene_or_gene_producttStrigger-to-trigger-path: e1:binds:Binding >conj_and [lemma='bind'] e2:bound:Bindingt7e2: trigger-arg-path: bound >nsubj [lemma='gab1'] themetWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] themetVe2: trigger-arg-path: bound:Binding >prep_to [lemma='egfr'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: to activated EGFRt(e2: args2Role-mention-ngram: directly ort"e2: ents2Label-mention-ngram: EGFRt&e2: ents2Label-mention-ngram: via Grb2tHe2: trigger-arg-path: bound >prep_to [lemma='egfr'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: EGFR eithert"e2: ents2Label-mention-ngram: Grb2tHe2: trigger-arg-path: Binding >nsubj [lemma='gab1'] Gene_or_gene_producttAe2: trigger-arg-path: bound:Binding >prep_to [lemma='egfr'] themetNe1: trigger-arg-path: Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: EGFR eithert)e2: ents2Label-mention-ngram: or via Grb2tHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='gab1'] themet2e2: args2Role-mention-ngram: activated EGFR eithert_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: Grb2 bound totPe2: trigger-arg-path: bound:Binding >prep_to [lemma='egfr'] Gene_or_gene_producttNe2: trigger-arg-path: Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: directly or viatee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: bound >prep_to [lemma='egfr'] themetFe2: trigger-arg-path: bound >nsubj [lemma='gab1'] Gene_or_gene_producttYtrigger-to-trigger-path: e1:binds:Binding >prep_to >amod e2:activated:Positive_activationt{trigger-to-trigger-path: e1:binds:Binding >prep_to [lemma='egfr'] >amod [lemma='activate'] e2:activated:Positive_activationtLe2: trigger-arg-path: binds >nsubj [lemma='gab1'] theme:Gene_or_gene_producttTe2: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] Gene_or_gene_productt?e2: trigger-arg-path: binds:Binding >nsubj [lemma='gab1'] themet7e2: trigger-arg-path: binds >nsubj [lemma='gab1'] themetFe2: trigger-arg-path: binds >nsubj [lemma='gab1'] Gene_or_gene_productt#e1: args2Role-mention-ngram: or viat?e1: trigger-arg-path: activated nsubj [lemma='gab1'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: or via Grb2tYtrigger-to-trigger-path: e1:activated:Positive_activation nsubj [lemma='gab1'] controllert?e1: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: activated EGFRt,e1: args2Role-mention-ngram: either directlyt!e1: args2Role-mention-ngram: EGFRtwe1: trigger-arg-path: Positive_activation nsubj [lemma='gab1'] controllert2e1: args2Role-mention-ngram: activated EGFR eithert~e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] controllert(e1: args2Role-mention-ngram: EGFR eithert3e1: ents2Label-mention-ngram: activated EGFR eithert?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: directly or viat(e1: args2Role-mention-ngram: or via Grb2t/e1: ents2Label-mention-ngram: to activated EGFRt,e1: ents2Label-mention-ngram: via Grb2 boundt$e1: ents2Label-mention-ngram: eithert+e1: ents2Label-mention-ngram: Grb2 bound totwtrigger-to-trigger-path: e1:activated:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: Grb2 boundt2e1: ents2Label-mention-ngram: EGFR either directlyt)e1: ents2Label-mention-ngram: directly ort#e1: args2Role-mention-ngram: eithert'e1: args2Role-mention-ngram: Grb2 boundt0e1: ents2Label-mention-ngram: either directly ort/e1: args2Role-mention-ngram: either directly ort"e1: ents2Label-mention-ngram: EGFRt?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] Gene_or_gene_productt$e1: ents2Label-mention-ngram: or viat/e1: args2Role-mention-ngram: bound to activatedt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: activated EGFRt+e1: args2Role-mention-ngram: via Grb2 boundt1e1: args2Role-mention-ngram: EGFR either directlyt*e1: args2Role-mention-ngram: Grb2 bound tot2e1: args2Role-mention-ngram: CONTROLLER also bindst%e1: args2Role-mention-ngram: via Grb2t?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation nsubj [lemma='gab1'] controllert&e1: ents2Label-mention-ngram: via Grb2t?e1: trigger-arg-path: activated:Positive_activation nsubj [lemma='gab1'] controllert.e1: args2Role-mention-ngram: to activated EGFRt?e1: trigger-arg-path: lemmatizedTrigger=activate nsubj [lemma='gab1'] controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: directly ort0e1: ents2Label-mention-ngram: bound to activatedtwe1: trigger-arg-path: activated nsubj [lemma='gab1'] Gene_or_gene_productt,e1: args2Role-mention-ngram: directly or viat)e1: ents2Label-mention-ngram: EGFR eithertAe2: ents2Label-mention-ngram: phosphorylates GENE_OR_GENE_PRODUCTt5e1: ents2Label-mention-ngram: signal regulated kinasetTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ask1'] Gene_or_gene_producttinterceding-token ngrams: ( Junt-interceding-token ngrams: N-terminal kinase )t)e1: args2Role-mention-ngram: 1 ) upstreamtVe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT phosphorylates GENE_OR_GENE_PRODUCTt$interceding-token ngrams: kinase ) .t8e1: ents2Label-mention-ngram: apoptosis signal regulatedt*e1: ents2Label-mention-ngram: inhibit ASK1tze1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='raf-1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: inhibit >nsubj [lemma='raf-1'] controllert-e1: args2Role-mention-ngram: can inhibit ASK1te2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ask1'] controller:Gene_or_gene_productt(interceding-token ngrams: Jun N-terminalt$e1: ents2Label-mention-ngram: signaltze1: trigger-arg-path: Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlled:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp >prep_of controlled:Gene_or_gene_productt/e1: args2Role-mention-ngram: ( apoptosis signaltYe2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ask1'] controllert+e1: ents2Label-mention-ngram: ) upstream oft)e1: ents2Label-mention-ngram: ( apoptosistJe1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp >prep_of controlledt/interceding-token ngrams: Jun N-terminal kinaset.e1: ents2Label-mention-ngram: apoptosis signalte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlledt>e1: ents2Label-mention-ngram: upstream of GENE_OR_GENE_PRODUCTt*e1: ents2Label-mention-ngram: 1 ) upstreamt*interceding-token ngrams: ( Jun N-terminalt[e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='raf-1'] Gene_or_gene_producttZe2: trigger-arg-path: phosphorylates >nsubj [lemma='ask1'] controller:Gene_or_gene_productt!e1: args2Role-mention-ngram: ASK1tJe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ask1'] controllert(e1: ents2Label-mention-ngram: ) upstreamt/e1: args2Role-mention-ngram: regulated kinase 1tte2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ask1'] Gene_or_gene_producttOe2: trigger-arg-path: phosphorylates >nsubj [lemma='ask1'] Gene_or_gene_productt+interceding-token ngrams: N-terminal kinaset`e1: trigger-arg-path: Negative_activation >nsubj [lemma='raf-1'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: signal regulatedt`e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ask1'] Gene_or_gene_productt!e1: ents2Label-mention-ngram: 1 )t$e1: ents2Label-mention-ngram: ASK1 (t0e1: ents2Label-mention-ngram: ( apoptosis signaltce1: trigger-arg-path: inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] Gene_or_gene_productt#e1: args2Role-mention-ngram: signalt.e1: ents2Label-mention-ngram: ASK1 ( apoptosistQe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='raf-1'] controllert.e1: ents2Label-mention-ngram: regulated kinaset(e1: args2Role-mention-ngram: ( apoptosistYe1: trigger-arg-path: inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: ) upstreamtYe1: trigger-arg-path: Negative_activation >xcomp >prep_of controlled:Gene_or_gene_productthe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='raf-1'] controller:Gene_or_gene_producttee1: trigger-arg-path: Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlledt-e1: args2Role-mention-ngram: apoptosis signaltue1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] Gene_or_gene_producttUe1: trigger-arg-path: Negative_activation >nsubj [lemma='raf-1'] Gene_or_gene_producttDe1: trigger-arg-path: Negative_activation >xcomp >prep_of controlledt%e1: args2Role-mention-ngram: kinase 1t%e1: args2Role-mention-ngram: upstreamtTe1: trigger-arg-path: inhibit >nsubj [lemma='raf-1'] controller:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ask1'] controller:Gene_or_gene_producttme1: trigger-arg-path: inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlledtTe1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp >prep_of Gene_or_gene_producttLe1: trigger-arg-path: inhibit:Negative_activation >xcomp >prep_of controlledt4e1: args2Role-mention-ngram: signal regulated kinasetwe1: trigger-arg-path: inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] Gene_or_gene_productt+e1: args2Role-mention-ngram: inhibit ASK1 (t0e1: ents2Label-mention-ngram: regulated kinase 1toe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='raf-1'] Gene_or_gene_producttKe1: trigger-arg-path: Negative_activation >nsubj [lemma='raf-1'] controllert#interceding-token ngrams: JNK ( Junt&e1: ents2Label-mention-ngram: upstreamt&e1: ents2Label-mention-ngram: kinase 1tinterceding-token ngrams: Junt*e1: args2Role-mention-ngram: ) upstream oftNe1: trigger-arg-path: Negative_activation >xcomp >prep_of Gene_or_gene_producttSe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='raf-1'] controllertee1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='raf-1'] controllert?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlled:Gene_or_gene_productt)e1: ents2Label-mention-ngram: upstream oft#e1: args2Role-mention-ngram: ASK1 (t]e1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='raf-1'] Gene_or_gene_productt-e1: args2Role-mention-ngram: signal regulatedt-e1: args2Role-mention-ngram: ASK1 ( apoptosist^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp >prep_of controlledtinterceding-token ngrams: JNK (t_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ask1'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: upstream of CONTROLLEDt-e1: args2Role-mention-ngram: regulated kinasetne1: trigger-arg-path: inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlled:Gene_or_gene_producttBe1: trigger-arg-path: inhibit >xcomp >prep_of Gene_or_gene_productt8e1: trigger-arg-path: inhibit >xcomp >prep_of controlledtke1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlledtae1: trigger-arg-path: inhibit:Negative_activation >xcomp >prep_of controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: kinase 1 )t_e1: trigger-arg-path: lemmatizedTrigger=inhibit >xcomp >prep_of controlled:Gene_or_gene_productt&e1: args2Role-mention-ngram: apoptosistAinterceding-tokens-full-span: and JNK ( Jun N-terminal kinase ) .tVe1: trigger-arg-path: inhibit:Negative_activation >xcomp >prep_of Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp >prep_of Gene_or_gene_productt(e1: ents2Label-mention-ngram: kinase 1 )t)e1: args2Role-mention-ngram: inhibit ASK1toe1: trigger-arg-path: Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] Gene_or_gene_producttce2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ask1'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: can inhibit ASK1t,e1: ents2Label-mention-ngram: inhibit ASK1 (t(e1: args2Role-mention-ngram: upstream oftIe1: trigger-arg-path: inhibit >nsubj [lemma='raf-1'] Gene_or_gene_producttne2: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='ask1'] controller:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='raf-1'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='ask1'] controllert?e1: trigger-arg-path: inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] controlled:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >xcomp [lemma='upstream'] >prep_of [lemma='p38'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='ask1'] controllert7e1: args2Role-mention-ngram: apoptosis signal regulatedt'e1: ents2Label-mention-ngram: apoptosistMe1: trigger-arg-path: inhibit >xcomp >prep_of controlled:Gene_or_gene_producttEe2: trigger-arg-path: phosphorylates >nsubj [lemma='ask1'] controllert#interceding-token ngrams: and JNK (t e1: args2Role-mention-ngram: 1 )t?e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='rassf1'] theme:Gene_or_gene_productt7interceding-tokens-full-span: proteins . For instance ,t9e2: trigger-arg-path: binds >dobj [lemma='rassf1c'] themetge1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] theme:Familyt$interceding-token ngrams: instance ,t;e2: trigger-arg-path: Binding >dobj [lemma='rassf1c'] themet(interceding-token ngrams: . For instancet@e1: trigger-arg-path: association >prep_between >nn theme:FamilytRe1: trigger-arg-path: lemmatizedTrigger=association >prep_between >nn theme:Familytae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='rassf1'] themetVe2: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='ra'] themetqe1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='rassf1'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='ra'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttke1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='rassf1'] Gene_or_gene_producttUe1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='ra'] Familytme1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] theme:Gene_or_gene_producttve1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] themet_e1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='ra'] theme:Familyt%CSSPATH: ROOT >dobj >prep_of ++ ROOT t"interceding-token ngrams: instancetye1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] theme:FamilytYe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] Gene_or_gene_producttae1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] FamilytZe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between >nn theme:FamilytHe1: trigger-arg-path: association:Binding >prep_between >nn theme:Familytse1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] Gene_or_gene_productt\e1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='rassf1'] themetTe1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='ra'] themetPe2: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] Gene_or_gene_productt(interceding-token ngrams: proteins . Fort:e1: trigger-arg-path: association >prep_between >nn FamilytXe1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] themetTe1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between >nn FamilytRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] themet?e2: ents2Label-mention-ngram: SHARED binds GENE_OR_GENE_PRODUCTtAe2: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] themet[e1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='ra'] theme:FamilytXe1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='ra'] themetge1: trigger-arg-path: Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=association >prep_between >nn FamilytYe1: trigger-arg-path: association >prep_between [lemma='protein'] >nn [lemma='ra'] Familyt(interceding-token ngrams: For instance ,tNe2: trigger-arg-path: binds >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttPe2: trigger-arg-path: Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttHe2: trigger-arg-path: binds >dobj [lemma='rassf1c'] Gene_or_gene_producttde1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] themetre1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] themet?e1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] theme:Gene_or_gene_producttFe1: ents2Label-mention-ngram: association between GENE_OR_GENE_PRODUCTtJe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] themet}e1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='rassf1'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] Familyt`e1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='ra'] themetBe1: trigger-arg-path: association:Binding >prep_between >nn Familytye1: trigger-arg-path: association:Binding >prep_between [lemma='protein'] >nn [lemma='rassf1'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=association >prep_between [lemma='protein'] >nn [lemma='ra'] theme:FamilytJe2: trigger-arg-path: Binding >dobj [lemma='rassf1c'] Gene_or_gene_productt&interceding-token ngrams: For instancet-interceding-token ngrams: Because RASSF1A hastJe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] themetHe1: trigger-arg-path: binds >dobj [lemma='rassf1c'] Gene_or_gene_productt+interceding-token ngrams: the identical Rast$interceding-token ngrams: as RASSF1Ct?interceding-tokens-full-span: in a GTP dependent manner to mediate apoptosis . Because RASSF1A has the identical Ras associate domain as RASSF1C ,tae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] Gene_or_gene_productt'interceding-token ngrams: identical Rast-interceding-token ngrams: mediate apoptosis .t#interceding-token ngrams: manner totKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf1a'] themet-e2: trigger-arg-path: bind >dobj theme:Familyt+interceding-token ngrams: manner to mediatet/e2: trigger-arg-path: bind:Binding >dobj FamilytYe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] Gene_or_gene_producttVe1: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >dobj [lemma='rassf1c'] Gene_or_gene_producttdobj [lemma='ra'] Familyt%interceding-token ngrams: RASSF1A hastbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_productt5e2: trigger-arg-path: bind:Binding >dobj theme:Familyt;e1: trigger-arg-path: Binding >dobj [lemma='rassf1c'] themet-interceding-token ngrams: dependent manner tot`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt#interceding-token ngrams: identicalt4e2: trigger-arg-path: bind >dobj [lemma='ra'] Familytge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt)interceding-token ngrams: RASSF1A has thet1interceding-token ngrams: identical Ras associatetHe2: trigger-arg-path: bind >nsubj [lemma='rassf1a'] Gene_or_gene_producttAe1: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] themetSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf1a'] themet$interceding-token ngrams: to mediatet'interceding-token ngrams: Ras associatetAe2: trigger-arg-path: bind:Binding >nsubj [lemma='rassf1a'] themet-interceding-token ngrams: apoptosis . Becauset'e2: trigger-arg-path: bind >dobj Familyt*interceding-token ngrams: associate domaintBe2: trigger-arg-path: bind:Binding >dobj [lemma='ra'] theme:Familyt+interceding-token ngrams: mediate apoptosistZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf1a'] Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >dobj [lemma='rassf1c'] Gene_or_gene_productt;e2: trigger-arg-path: bind:Binding >dobj [lemma='ra'] themet:e2: trigger-arg-path: bind >dobj [lemma='ra'] theme:Familyt9e1: trigger-arg-path: binds >dobj [lemma='rassf1c'] themet#interceding-token ngrams: domain ast9e2: trigger-arg-path: bind >nsubj [lemma='rassf1a'] themet#interceding-token ngrams: RASSF1C ,tNe2: trigger-arg-path: bind >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt+interceding-token ngrams: domain as RASSF1CtNe1: trigger-arg-path: binds >dobj [lemma='rassf1c'] theme:Gene_or_gene_productt'interceding-token ngrams: the identicaltVe2: trigger-arg-path: bind:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='rassf1c'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >dobj [lemma='rassf1c'] theme:Gene_or_gene_productt!interceding-token ngrams: has thet-interceding-token ngrams: associate domain ast.interceding-token ngrams: to mediate apoptosist+interceding-token ngrams: has the identicalt+interceding-token ngrams: . Because RASSF1At.interceding-token ngrams: Ras associate domaint3e2: trigger-arg-path: bind >dobj [lemma='ra'] themet&interceding-token ngrams: as RASSF1C ,t)interceding-token ngrams: Because RASSF1AtRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='rassf1c'] themetPe2: trigger-arg-path: bind:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ECM'] Gene_or_gene_producttstrigger-to-trigger-path: e1:induced:Positive_regulation >advcl >xcomp >ccomp >advcl e2:mediated:Positive_regulationtHe2: trigger-arg-path: mediated >nsubj [lemma='ECM'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ECM'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ECM'] controllert+interceding-token ngrams: also required fort2interceding-token ngrams: fibronectin , indicatingtte1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_productt%interceding-token ngrams: fibronectint8interceding-token ngrams: phosphorylation independent oft*interceding-token ngrams: activity is alsot(interceding-token ngrams: R-Ras activitytge2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ECM'] controller:Gene_or_gene_productt1interceding-token ngrams: markedly stimulated FAKtOe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ECM'] controllertYe1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] controllertRe2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ECM'] controllertZe1: trigger-arg-path: induced >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt*interceding-token ngrams: of fibronectin ,t?shortest-path: advcl [lemma='stimulate'] >xcomp [lemma='indicate'] >ccomp [lemma='require'] >advcl [lemma='mediate'] >nsubj [lemma='ECM']tke1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt>e2: trigger-arg-path: mediated >nsubj [lemma='ECM'] controllert-interceding-token ngrams: markedly stimulatedt5interceding-token ngrams: phosphorylation independentt+interceding-token ngrams: R-Ras-QL markedlytinterceding-token ngrams: R-Rast\e2: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='ECM'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] Gene_or_gene_productt6interceding-token ngrams: R-Ras-QL markedly stimulatedt?trigger-to-trigger-path: e1:induced:Positive_regulation >advcl [lemma='stimulate'] >xcomp [lemma='indicate'] >ccomp [lemma='require'] >advcl [lemma='mediate'] e2:mediated:Positive_regulationt-interceding-token ngrams: FAK phosphorylationtme2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ECM'] Gene_or_gene_productt[e1: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_productt?interceding-tokens-full-span: , whereas R-Ras-QL markedly stimulated FAK phosphorylation independent of fibronectin , indicating that endogenous R-Ras activity is also required fort(interceding-token ngrams: of fibronectint(interceding-token ngrams: stimulated FAKt3interceding-token ngrams: endogenous R-Ras activitytSe2: trigger-arg-path: mediated >nsubj [lemma='ECM'] controller:Gene_or_gene_productt8interceding-token ngrams: stimulated FAK phosphorylationtxe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='ECM'] controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] controllertIe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ECM'] controllert*interceding-token ngrams: whereas R-Ras-QLtinterceding-token ngrams: FAKt*interceding-token ngrams: is also requiredtVe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] controllert,interceding-token ngrams: , whereas R-Ras-QLt*interceding-token ngrams: endogenous R-Rast'interceding-token ngrams: fibronectin ,tce1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_productt"interceding-token ngrams: R-Ras-QLte1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt9interceding-token ngrams: FAK phosphorylation independentt'interceding-token ngrams: also requiredtQe1: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] controllert4interceding-token ngrams: independent of fibronectintYe2: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='ECM'] Gene_or_gene_productt/interceding-token ngrams: that endogenous R-RastOe1: trigger-arg-path: induced >nsubj [lemma='fibronectin'] Gene_or_gene_productt8shortest-path: advcl >xcomp >ccomp >advcl >nsubjtEe1: trigger-arg-path: induced >nsubj [lemma='fibronectin'] controllertne1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ECM'] controller:Gene_or_gene_productt3interceding-token ngrams: whereas R-Ras-QL markedlyt+interceding-token ngrams: R-Ras activity istfe1: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt4interceding-token ngrams: indicating that endogenoustLe1: trigger-arg-path: blocked:Negative_regulation >ccomp Positive_regulationt(e1: args2Role-mention-ngram: blocked thet2e1: args2Role-mention-ngram: CONTROLLER completelytTe1: trigger-arg-path: blocked >ccomp [lemma='induce'] controlled:Positive_regulationt=e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT completelyt@e1: trigger-arg-path: blocked >ccomp [lemma='induce'] controlledt?e1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controller:Gene_or_gene_productt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] Gene_or_gene_producttde1: trigger-arg-path: blocked >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controllertxe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt/e1: trigger-arg-path: blocked >ccomp controlledtde1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp [lemma='induce'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] Gene_or_gene_productthe1: trigger-arg-path: blocked:Negative_regulation >ccomp [lemma='induce'] controlled:Positive_regulationtme1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtztrigger-to-trigger-path: e1:blocked:Negative_regulation >ccomp >advcl >xcomp >ccomp >advcl e2:mediated:Positive_regulationt8e1: trigger-arg-path: blocked >ccomp Positive_regulationt~e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCT inducedtHe1: trigger-arg-path: lemmatizedTrigger=block >ccomp Positive_regulationtEe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT completely blockedtze1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=block >ccomp [lemma='induce'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: completely blocked thetTe1: trigger-arg-path: blocked:Negative_regulation >ccomp [lemma='induce'] controlledt/e1: args2Role-mention-ngram: completely blockedt4e1: ents2Label-mention-ngram: completely blocked thet\e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp Positive_regulationt'e1: args2Role-mention-ngram: completelytye1: trigger-arg-path: blocked >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: blocked the CONTROLLEDtYe1: trigger-arg-path: lemmatizedTrigger=block >ccomp [lemma='induce'] Positive_regulationtge1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp controlled:Positive_regulationt(e1: ents2Label-mention-ngram: completelyt?trigger-to-trigger-path: e1:blocked:Negative_regulation >ccomp [lemma='induce'] >advcl [lemma='stimulate'] >xcomp [lemma='indicate'] >ccomp [lemma='require'] >advcl [lemma='mediate'] e2:mediated:Positive_regulationt0e1: ents2Label-mention-ngram: completely blockedtHshortest-path: ccomp >advcl >xcomp >ccomp >advcl >nsubjtne1: trigger-arg-path: blocked >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controller:Gene_or_gene_producttxe1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controllertSe1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >ccomp controlledtSe1: trigger-arg-path: lemmatizedTrigger=block >ccomp controlled:Positive_regulationtIe1: trigger-arg-path: blocked >ccomp [lemma='induce'] Positive_regulationt)e1: ents2Label-mention-ngram: blocked thet>e1: ents2Label-mention-ngram: blocked the GENE_OR_GENE_PRODUCTtde1: trigger-arg-path: lemmatizedTrigger=block >ccomp [lemma='induce'] controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=block >ccomp controlledt]e1: trigger-arg-path: blocked:Negative_regulation >ccomp [lemma='induce'] Positive_regulationtte1: trigger-arg-path: lemmatizedTrigger=block >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controllert?e1: trigger-arg-path: lemmatizedTrigger=block:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controllert?shortest-path: ccomp [lemma='induce'] >advcl [lemma='stimulate'] >xcomp [lemma='indicate'] >ccomp [lemma='require'] >advcl [lemma='mediate'] >nsubj [lemma='ECM']tWe1: trigger-arg-path: blocked:Negative_regulation >ccomp controlled:Positive_regulationt?e1: trigger-arg-path: blocked:Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controller:Gene_or_gene_producttpe1: trigger-arg-path: Negative_regulation >nsubj [lemma='expression'] >prep_of [lemma='myr-r-rasgap'] controllert:e1: args2Role-mention-ngram: CONTROLLER completely blockedtCe1: trigger-arg-path: blocked:Negative_regulation >ccomp controlledtCe1: trigger-arg-path: blocked >ccomp controlled:Positive_regulationtZe2: trigger-arg-path: induced >nsubj [lemma='fibronectin'] controller:Gene_or_gene_producttYe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] controllertne2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: blocked the SHAREDtQe2: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] controllertxshortest-path: ccomp [lemma='induce'] >nsubj [lemma='fibronectin']tEe2: trigger-arg-path: induced >nsubj [lemma='fibronectin'] controllert[e2: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] controller:Gene_or_gene_producttfe2: trigger-arg-path: Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] controllert0e1: ents2Label-mention-ngram: the SHARED inducedte2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] controllertce2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_producttte2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='fibronectin'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='fibronectin'] Gene_or_gene_producttOe2: trigger-arg-path: induced >nsubj [lemma='fibronectin'] Gene_or_gene_producttqshortest-path: dobj [lemma='activation'] >nn [lemma='ecm']tXe2: trigger-arg-path: activation:Positive_regulation >nn controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: integrins and tyrosinet=e2: trigger-arg-path: activation >nn [lemma='ecm'] controllert:e2: ents2Label-mention-ngram: and tyrosine phosphorylationtue1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controller:Gene_or_gene_producttLe1: trigger-arg-path: induces:Positive_regulation >nsubj >prep_of controllert3e2: args2Role-mention-ngram: independent functionalt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controllertDe2: trigger-arg-path: activation >nn controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: integrins andtOe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ecm'] controllert4e1: ents2Label-mention-ngram: integrins and tyrosinet4e1: ents2Label-mention-ngram: independent functionaltRe2: trigger-arg-path: activation >nn [lemma='ecm'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] Gene_or_gene_producttVe1: trigger-arg-path: induces:Positive_regulation >nsubj >prep_of Gene_or_gene_producttFe2: trigger-arg-path: Positive_regulation >nn [lemma='ecm'] controllert6e2: ents2Label-mention-ngram: functional activation oft3e1: ents2Label-mention-ngram: functional activationtGe2: trigger-arg-path: activation >nn [lemma='ecm'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: functional activationt-e2: args2Role-mention-ngram: beta 1 integrinst.e1: ents2Label-mention-ngram: beta 1 integrinst0e1: ents2Label-mention-ngram: activation of betat$e1: ents2Label-mention-ngram: beta 1t,e2: args2Role-mention-ngram: 1 integrins andtfe2: trigger-arg-path: activation:Positive_regulation >nn [lemma='ecm'] controller:Gene_or_gene_productt$e2: ents2Label-mention-ngram: beta 1t[e2: trigger-arg-path: activation:Positive_regulation >nn [lemma='ecm'] Gene_or_gene_producttMe2: trigger-arg-path: activation:Positive_regulation >nn Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ecm'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: the SHARED independenttje2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: integrinst5e2: args2Role-mention-ngram: functional activation oft)e2: ents2Label-mention-ngram: 1 integrinst'e2: ents2Label-mention-ngram: integrinst'e2: ents2Label-mention-ngram: of beta 1t+e1: ents2Label-mention-ngram: integrins andt>e2: args2Role-mention-ngram: CONTROLLER independent functionalt&e2: args2Role-mention-ngram: of beta 1t?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: CONTROLLER independentt;e2: ents2Label-mention-ngram: SHARED independent functionalt(e2: args2Role-mention-ngram: 1 integrinst-e1: ents2Label-mention-ngram: 1 integrins andt)e2: ents2Label-mention-ngram: independentt4e2: ents2Label-mention-ngram: integrins and tyrosinetVe2: trigger-arg-path: lemmatizedTrigger=activation >nn controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: activation of betat_trigger-to-trigger-path: e1:induces:Positive_regulation >dobj e2:activation:Positive_regulationtje1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: of betat?e1: ents2Label-mention-ngram: independent functional activationt/e2: args2Role-mention-ngram: activation of betat0e1: ents2Label-mention-ngram: SHARED independentt#e2: args2Role-mention-ngram: beta 1t*e1: ents2Label-mention-ngram: and tyrosinet:e1: ents2Label-mention-ngram: and tyrosine phosphorylationt4e2: ents2Label-mention-ngram: independent functionalt*e2: ents2Label-mention-ngram: and tyrosinetPe2: trigger-arg-path: Positive_regulation >nn [lemma='ecm'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: functionalt)e1: ents2Label-mention-ngram: 1 integrinst;e1: ents2Label-mention-ngram: SHARED independent functionaltte1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controllert_e2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn Gene_or_gene_productt'e2: args2Role-mention-ngram: functionalt(e2: args2Role-mention-ngram: independenttxe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='ecm'] controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: independentt?e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: integrinst'e1: ents2Label-mention-ngram: of beta 1tde2: trigger-arg-path: lemmatizedTrigger=activation >nn [lemma='ecm'] controller:Gene_or_gene_productt[e2: trigger-arg-path: Positive_regulation >nn [lemma='ecm'] controller:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] Gene_or_gene_productt?e2: ents2Label-mention-ngram: independent functional activationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controller:Gene_or_gene_producttttrigger-to-trigger-path: e1:induces:Positive_regulation >dobj [lemma='activation'] e2:activation:Positive_regulationt>e2: args2Role-mention-ngram: independent functional activationt?e1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controller:Gene_or_gene_producttle1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controllert0e1: ents2Label-mention-ngram: induces the SHAREDtce2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='ecm'] controllertae1: trigger-arg-path: induces:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: betat%e1: ents2Label-mention-ngram: of betatUe2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn controllert.e2: ents2Label-mention-ngram: beta 1 integrinstCe2: trigger-arg-path: activation:Positive_regulation >nn controllert2e2: args2Role-mention-ngram: functional activationt0e2: ents2Label-mention-ngram: SHARED independentt4e2: args2Role-mention-ngram: and tyrosine CONTROLLEDtme2: trigger-arg-path: lemmatizedTrigger=activation:Positive_regulation >nn [lemma='ecm'] Gene_or_gene_productt6e1: ents2Label-mention-ngram: functional activation oftqe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controllert)e2: args2Role-mention-ngram: and tyrosinet*e2: args2Role-mention-ngram: integrins andt$e2: args2Role-mention-ngram: of betat`e1: trigger-arg-path: induces >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] controllertve1: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] Gene_or_gene_productt-e2: ents2Label-mention-ngram: 1 integrins andtQe2: trigger-arg-path: activation:Positive_regulation >nn [lemma='ecm'] controllert~e1: trigger-arg-path: induces:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='r-ras-ql'] Gene_or_gene_producttQe1: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: the constitutivelytSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] themetDe2: trigger-arg-path: bound >prep_to [lemma='mutant'] Generic_entitytAe1: trigger-arg-path: bound:Binding >prep_to theme:Generic_entityt[e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] theme:Generic_entityt*e2: ents2Label-mention-ngram: bound to thetJe2: trigger-arg-path: bound >prep_to [lemma='mutant'] theme:Generic_entitythe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt6e1: args2Role-mention-ngram: the constitutively activetFe1: trigger-arg-path: Binding >prep_to [lemma='mutant'] Generic_entityt9e1: trigger-arg-path: bound >prep_to theme:Generic_entitytnsubj [lemma='da-raf1'] themetQe1: trigger-arg-path: Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt)e2: args2Role-mention-ngram: active THEMEtLe1: trigger-arg-path: Binding >prep_to [lemma='mutant'] theme:Generic_entitytJe1: trigger-arg-path: bound >prep_to [lemma='mutant'] theme:Generic_entitytWe2: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_producttLe2: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] Generic_entityt0e2: ents2Label-mention-ngram: the constitutivelytKe1: trigger-arg-path: Binding >nsubj [lemma='da-raf1'] Gene_or_gene_productt8e2: args2Role-mention-ngram: constitutively active THEMEt2e2: args2Role-mention-ngram: constitutively activetIe1: trigger-arg-path: bound >nsubj [lemma='da-raf1'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] Generic_entityt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] Generic_entityt)e2: args2Role-mention-ngram: bound to thet/e2: args2Role-mention-ngram: the constitutivelytUe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] Generic_entitytbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] Gene_or_gene_producttRe1: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] theme:Generic_entityt6e2: args2Role-mention-ngram: the constitutively activetnsubj [lemma='da-raf1'] themet2e2: args2Role-mention-ngram: to the constitutivelytLe1: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] Generic_entitytAe2: trigger-arg-path: bound:Binding >prep_to theme:Generic_entitytbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nsubj [lemma='da-raf1'] Gene_or_gene_productt;e1: trigger-arg-path: bound:Binding >prep_to Generic_entityt:e1: ents2Label-mention-ngram: constitutively active SHAREDtCe1: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] themet;e2: trigger-arg-path: bound >prep_to [lemma='mutant'] themet`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt3e2: trigger-arg-path: bound >prep_to Generic_entitytTe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] themet3e1: trigger-arg-path: bound >prep_to Generic_entitytZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] Gene_or_gene_productt;e2: trigger-arg-path: bound:Binding >prep_to Generic_entitytce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] theme:Generic_entitytUe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] Generic_entitytOe1: trigger-arg-path: bound >nsubj [lemma='da-raf1'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] theme:Generic_entitytSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] themetLe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] themetOe2: trigger-arg-path: bound >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: bound >prep_to theme:Generic_entityt2e1: args2Role-mention-ngram: constitutively activet:e1: trigger-arg-path: bound >nsubj [lemma='da-raf1'] themet;e1: trigger-arg-path: bound >prep_to [lemma='mutant'] themet3e2: ents2Label-mention-ngram: constitutively activetTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='mutant'] themet3e1: ents2Label-mention-ngram: constitutively activetFe2: trigger-arg-path: Binding >prep_to [lemma='mutant'] Generic_entityt2e1: args2Role-mention-ngram: to the constitutivelytWe1: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] themet7e2: ents2Label-mention-ngram: the constitutively activetDe1: trigger-arg-path: bound >prep_to [lemma='mutant'] Generic_entityt3e2: ents2Label-mention-ngram: to the constitutivelytZe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: to the constitutivelytBe1: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] themet=e1: trigger-arg-path: Binding >prep_to [lemma='mutant'] themet=e2: trigger-arg-path: Binding >prep_to [lemma='mutant'] themetQe2: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] themetKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] themetCe2: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] themet/e1: args2Role-mention-ngram: the constitutivelytBe2: trigger-arg-path: bound:Binding >nsubj [lemma='da-raf1'] themetQe2: trigger-arg-path: Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt7e1: ents2Label-mention-ngram: the constitutively activet8e1: args2Role-mention-ngram: constitutively active THEMEtLe2: trigger-arg-path: Binding >prep_to [lemma='mutant'] theme:Generic_entityt:e2: ents2Label-mention-ngram: constitutively active SHAREDt:e2: trigger-arg-path: bound >nsubj [lemma='da-raf1'] themetRe2: trigger-arg-path: bound:Binding >prep_to [lemma='mutant'] theme:Generic_entitytIe2: trigger-arg-path: bound >nsubj [lemma='da-raf1'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='da-raf1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='mutant'] theme:Generic_entityt!interceding-token ngrams: H-Ras (tinterceding-token ngrams: ) butt)e1: args2Role-mention-ngram: did not bindt%interceding-token ngrams: ( both wildt%interceding-token ngrams: but also tot*e1: args2Role-mention-ngram: THEME did nottinterceding-token ngrams: and at&e1: ents2Label-mention-ngram: negativet$interceding-token ngrams: G22V ) butt'interceding-token ngrams: G12V mutant )t,e2: ents2Label-mention-ngram: bound not onlyt%e2: ents2Label-mention-ngram: only tot(e1: args2Role-mention-ngram: not bind totinterceding-token ngrams: G12Vt1interceding-token ngrams: a constitutively activet4e1: args2Role-mention-ngram: their dominant negativet+e2: args2Role-mention-ngram: bound not onlyt{interceding-tokens-full-span: G22V ) but also to H-Ras ( both wild type and a constitutively active G12V mutant ) , whereast7e1: ents2Label-mention-ngram: dominant negative mutantstbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: their dominanttKe2: trigger-arg-path: Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt$interceding-token ngrams: type and at:e2: ents2Label-mention-ngram: only to GENE_OR_GENE_PRODUCTt*e1: ents2Label-mention-ngram: did not bindt*e1: args2Role-mention-ngram: bind to theirt%e1: args2Role-mention-ngram: dominanttZe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] Gene_or_gene_productte1: ents2Label-mention-ngram: Mt interceding-token ngrams: ( botht$e1: args2Role-mention-ngram: M THEMEt&e1: ents2Label-mention-ngram: dominantt%e1: args2Role-mention-ngram: to theirtOtrigger-to-trigger-path: e1:bind:Binding nsubj [lemma='DA-Raf1'] themet/e1: ents2Label-mention-ngram: dominant negativet0e1: ents2Label-mention-ngram: negative mutants Mt/interceding-token ngrams: constitutively activet.e2: ents2Label-mention-ngram: SHARED bound nott&e1: ents2Label-mention-ngram: to theirt)e2: ents2Label-mention-ngram: not only tot,e1: args2Role-mention-ngram: mutants M THEMEt.interceding-token ngrams: and a constitutivelyt'interceding-token ngrams: also to H-Rast$e2: args2Role-mention-ngram: only tot&e2: args2Role-mention-ngram: bound nottOe2: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: negative mutantst$interceding-token ngrams: to H-Ras (t'e1: ents2Label-mention-ngram: mutants Mt!interceding-token ngrams: also tot'e2: ents2Label-mention-ngram: bound notte1: args2Role-mention-ngram: Mt,e1: ents2Label-mention-ngram: their dominantt*interceding-token ngrams: a constitutivelytQe2: trigger-arg-path: Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt4interceding-token ngrams: constitutively active G12Vt&interceding-token ngrams: H-Ras ( bothtKe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] themet$interceding-token ngrams: ) but alsot.e1: ents2Label-mention-ngram: mutants M FAMILYtQe2: trigger-arg-path: bound:Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt:e2: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] themet$interceding-token ngrams: mutant ) ,t6e1: args2Role-mention-ngram: dominant negative mutantst(e1: ents2Label-mention-ngram: SHARED didtSshortest-path: nsubj [lemma='DA-Raf1']tinterceding-token ngrams: G22Vt#e1: ents2Label-mention-ngram: theirtnsubj [lemma='DA-Raf1'] themet`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt,interceding-token ngrams: active G12V mutantt"e1: args2Role-mention-ngram: theirt(e2: args2Role-mention-ngram: not only tothe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: SHARED did nottIe2: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt-e1: args2Role-mention-ngram: negative mutantstSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] themet%interceding-token ngrams: G12V mutantt&e1: args2Role-mention-ngram: THEME didt/e1: ents2Label-mention-ngram: to their dominantt5e1: ents2Label-mention-ngram: their dominant negativet)e1: ents2Label-mention-ngram: not bind tot+e1: ents2Label-mention-ngram: bind to theirt&e1: ents2Label-mention-ngram: M FAMILYt%e1: args2Role-mention-ngram: negativet*e2: args2Role-mention-ngram: only to THEMEt%interceding-token ngrams: active G12Vt.e1: args2Role-mention-ngram: dominant negativetWe2: trigger-arg-path: bound:Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_producttQe1: trigger-arg-path: bound:Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: their dominant negativet7e2: ents2Label-mention-ngram: dominant negative mutantst,e1: args2Role-mention-ngram: THEME bound nottOtrigger-to-trigger-path: e1:bound:Binding >advcl [lemma='bind'] e2:bind:Bindingt.e2: ents2Label-mention-ngram: negative mutantst/e2: ents2Label-mention-ngram: to their dominantt,e2: ents2Label-mention-ngram: SHARED did nottKe1: trigger-arg-path: Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_producttIe1: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: THEME did nottnsubj [lemma='DA-Raf1'] themetbe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt%e2: args2Role-mention-ngram: dominantt&e2: args2Role-mention-ngram: mutants Mt%e2: args2Role-mention-ngram: to theirte2: args2Role-mention-ngram: Mt.e2: ents2Label-mention-ngram: mutants M FAMILYt$e1: args2Role-mention-ngram: only tot'e2: ents2Label-mention-ngram: mutants Mt:e1: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] themetOe1: trigger-arg-path: bound >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: negative mutantstSe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] themet%e2: ents2Label-mention-ngram: did nott@trigger-to-trigger-path: e1:bound:Binding >advcl e2:bind:Bindingt*e2: args2Role-mention-ngram: bind to theirt&e2: ents2Label-mention-ngram: dominantt`e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productte2: ents2Label-mention-ngram: Mt(e2: ents2Label-mention-ngram: SHARED didt&e2: ents2Label-mention-ngram: to theirt%e1: ents2Label-mention-ngram: only totWe1: trigger-arg-path: bound:Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] themetBe1: trigger-arg-path: bound:Binding >nsubj [lemma='DA-Raf1'] themet+e1: args2Role-mention-ngram: bound not onlyt+e2: ents2Label-mention-ngram: bind to theirt*e2: ents2Label-mention-ngram: did not bindt.e2: args2Role-mention-ngram: dominant negativet&e1: args2Role-mention-ngram: bound nottZe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='DA-Raf1'] Gene_or_gene_productt)e2: ents2Label-mention-ngram: not bind tot$e2: args2Role-mention-ngram: M THEMEt$e2: args2Role-mention-ngram: did nott.e1: ents2Label-mention-ngram: SHARED bound nott)e1: ents2Label-mention-ngram: not only tot/e2: args2Role-mention-ngram: negative mutants Mt,e2: ents2Label-mention-ngram: their dominantt)e2: args2Role-mention-ngram: did not bindt4e2: args2Role-mention-ngram: their dominant negativet&e2: args2Role-mention-ngram: THEME didt,e2: args2Role-mention-ngram: mutants M THEMEt'e1: ents2Label-mention-ngram: bound nott0e2: ents2Label-mention-ngram: negative mutants Mt(e2: args2Role-mention-ngram: not bind tot:e1: ents2Label-mention-ngram: only to GENE_OR_GENE_PRODUCTt&e2: ents2Label-mention-ngram: M FAMILYt$e2: args2Role-mention-ngram: mutantst+e2: args2Role-mention-ngram: their dominantthe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt6e2: args2Role-mention-ngram: dominant negative mutantst*e1: args2Role-mention-ngram: only to THEMEt/e2: ents2Label-mention-ngram: dominant negativet,e1: ents2Label-mention-ngram: bound not onlyt"e2: args2Role-mention-ngram: theirt.e2: args2Role-mention-ngram: to their dominantt(e1: args2Role-mention-ngram: not only tot#e2: ents2Label-mention-ngram: theirtQe1: trigger-arg-path: Binding >nsubj [lemma='DA-Raf1'] theme:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttYe1: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] Gene_or_gene_productt>e2: ents2Label-mention-ngram: coimmunoprecipitated with SHAREDtCe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass themetYe2: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='DA-Raf1'] themet_e1: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: coimmunoprecipitatedtTe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with themet;e2: trigger-arg-path: coimmunoprecipitated >nsubjpass themetge1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt:e1: args2Role-mention-ngram: not coimmunoprecipitated witht=e1: trigger-arg-path: Binding >prep_with [lemma='h-ra'] themet6e1: args2Role-mention-ngram: coimmunoprecipitated withtRe2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='h-ra'] themetRe1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with Gene_or_gene_producttMe2: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='DA-Raf1'] themetae1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: not coimmunoprecipitatedt:e1: ents2Label-mention-ngram: was not coimmunoprecipitatedtJe2: trigger-arg-path: coimmunoprecipitated >prep_with Gene_or_gene_productt\e1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_productt\e2: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with Gene_or_gene_producttPe1: trigger-arg-path: coimmunoprecipitated >nsubjpass theme:Gene_or_gene_productt!e2: trigger: coimmunoprecipitatedtxe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass theme:Gene_or_gene_productt6e2: ents2Label-mention-ngram: not coimmunoprecipitatedtRe2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass Gene_or_gene_producttUe1: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass themetae1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with theme:Gene_or_gene_producttCe1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with themet;e1: trigger-arg-path: coimmunoprecipitated >nsubjpass themetJe1: trigger-arg-path: coimmunoprecipitated >prep_with Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with Gene_or_gene_productt5e1: args2Role-mention-ngram: not coimmunoprecipitatedt[e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with Gene_or_gene_productt@e2: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] themetLe2: trigger-arg-path: Binding >prep_with [lemma='h-ra'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with theme:Gene_or_gene_producttpe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttPe2: trigger-arg-path: coimmunoprecipitated >nsubjpass theme:Gene_or_gene_producttUe2: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_productt;e2: trigger-arg-path: coimmunoprecipitated >prep_with themetie1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass theme:Gene_or_gene_producttUe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] themetCe2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass themet[e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with Gene_or_gene_productt6e2: args2Role-mention-ngram: coimmunoprecipitated witht:e2: ents2Label-mention-ngram: was not coimmunoprecipitatedtOe1: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] themetLe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with themetPe2: trigger-arg-path: coimmunoprecipitated >prep_with theme:Gene_or_gene_producttJe2: trigger-arg-path: coimmunoprecipitated >nsubjpass Gene_or_gene_productt5e2: args2Role-mention-ngram: not coimmunoprecipitatedtXe2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass themetie1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with theme:Gene_or_gene_productt1e2: args2Role-mention-ngram: coimmunoprecipitatedtOe2: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttPe1: trigger-arg-path: coimmunoprecipitated >prep_with theme:Gene_or_gene_producttUe2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] themet;e2: ents2Label-mention-ngram: not coimmunoprecipitated withtRe1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] themetme2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_productt;e1: trigger-arg-path: coimmunoprecipitated >prep_with themet;e1: ents2Label-mention-ngram: not coimmunoprecipitated withtXe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass theme:Gene_or_gene_productt7e2: ents2Label-mention-ngram: coimmunoprecipitated withtMshortest-path: auxpass [lemma='be']t:e2: args2Role-mention-ngram: not coimmunoprecipitated witht>e1: ents2Label-mention-ngram: coimmunoprecipitated with SHAREDtRe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] themet@e1: trigger-arg-path: Binding >nsubjpass [lemma='DA-Raf1'] themet9e1: args2Role-mention-ngram: was not coimmunoprecipitatedtje2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttJe2: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] themet2e2: ents2Label-mention-ngram: coimmunoprecipitatedtme1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] themetLe1: trigger-arg-path: Binding >prep_with [lemma='h-ra'] Gene_or_gene_producttCe2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with themetXe1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] Gene_or_gene_producttXe2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with theme:Gene_or_gene_producttje1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] themet_e2: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] themetTe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass themetie2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass theme:Gene_or_gene_producttre2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] Gene_or_gene_productt7e1: ents2Label-mention-ngram: coimmunoprecipitated withtnsubjpass Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass Gene_or_gene_producttJe1: trigger-arg-path: coimmunoprecipitated >nsubjpass Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with theme:Gene_or_gene_producttRe2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] themetRe2: trigger-arg-path: Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with themetre1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='h-ra'] Gene_or_gene_producttae1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='h-ra'] themet{e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_productt9e2: args2Role-mention-ngram: was not coimmunoprecipitatedtTe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass themetfe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] themetae2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] Gene_or_gene_producttde2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttde1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with themet!e1: trigger: coimmunoprecipitatedtbe1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_productt2e1: ents2Label-mention-ngram: coimmunoprecipitatedtue1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='DA-Raf1'] Gene_or_gene_producttge2: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='DA-Raf1'] themetnsubjpass [lemma='DA-Raf1'] theme:Gene_or_gene_producttbe2: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_producttde1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: was coimmunoprecipitatedtfe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] themetbe1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] themet5e1: args2Role-mention-ngram: was coimmunoprecipitatedt=e1: ents2Label-mention-ngram: SHARED was coimmunoprecipitatedtse1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_productt:e1: args2Role-mention-ngram: was coimmunoprecipitated withtUe1: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_producttMe1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] themet6e2: ents2Label-mention-ngram: was coimmunoprecipitatedt\e2: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt\e1: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: SHARED was coimmunoprecipitatedtMe2: trigger-arg-path: coimmunoprecipitated >nsubjpass [lemma='da-raf1'] themet5e2: args2Role-mention-ngram: was coimmunoprecipitatedtue2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt;e2: ents2Label-mention-ngram: was coimmunoprecipitated witht:e2: args2Role-mention-ngram: was coimmunoprecipitated withtUe2: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_producttje2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt@e2: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] themet;e1: ents2Label-mention-ngram: was coimmunoprecipitated withtOe2: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_productt;e2: args2Role-mention-ngram: THEME was coimmunoprecipitatedtUe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] themet@e1: trigger-arg-path: Binding >nsubjpass [lemma='da-raf1'] themetme1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubjpass [lemma='da-raf1'] themetje1: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubjpass [lemma='da-raf1'] themetde2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] Gene_or_gene_producttUe2: trigger-arg-path: coimmunoprecipitated:Binding >nsubjpass [lemma='da-raf1'] themet;e1: args2Role-mention-ngram: THEME was coimmunoprecipitatedt#interceding-token ngrams: M-Ras andt\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='m-ra'] Gene_or_gene_productt)interceding-token ngrams: interfered witht+e1: trigger-arg-path: bound >prep_to FamilytBe2: trigger-arg-path: binding:Binding >prep_to [lemma='ra'] FamilytZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='ra'] theme:Familyt/e2: ents2Label-mention-ngram: active SHARED andt?e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to FamilytJe2: trigger-arg-path: binding >prep_to [lemma='m-ra'] Gene_or_gene_producttinterceding-token ngrams: M-Rast-interceding-token ngrams: interfered with thet,e2: args2Role-mention-ngram: to active THEMEtRe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='ra'] theme:Familyt3e2: trigger-arg-path: binding >prep_to theme:Familyt1e1: trigger-arg-path: bound >prep_to theme:Familyt8e1: trigger-arg-path: bound >prep_to [lemma='ra'] Familyt?e1: trigger-arg-path: bound:Binding >prep_to [lemma='ra'] themet'e2: ents2Label-mention-ngram: to activet&e2: args2Role-mention-ngram: to activetEe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to theme:Familyt-e2: args2Role-mention-ngram: active THEME andt/e2: ents2Label-mention-ngram: binding to activet@e1: trigger-arg-path: bound:Binding >prep_to [lemma='ra'] Familyt;e2: trigger-arg-path: Binding >prep_to [lemma='m-ra'] themetbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='m-ra'] theme:Gene_or_gene_productt#interceding-token ngrams: and M-Rast-interceding-token ngrams: and interfered witht&e1: args2Role-mention-ngram: to activetKe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='ra'] themetMe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to theme:Familyt,e1: args2Role-mention-ngram: bound to activetXe2: trigger-arg-path: binding:Binding >prep_to [lemma='m-ra'] theme:Gene_or_gene_productt'interceding-token ngrams: pathway . ThetPe2: trigger-arg-path: Binding >prep_to [lemma='m-ra'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='ra'] themetde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='m-ra'] Gene_or_gene_producttQinterceding-tokens-full-span: and M-Ras and interfered with the ERK pathway . Thet.e2: ents2Label-mention-ngram: to active SHAREDtAe2: trigger-arg-path: binding:Binding >prep_to [lemma='ra'] themet;e2: trigger-arg-path: binding:Binding >prep_to theme:Familyt:e2: trigger-arg-path: binding >prep_to [lemma='ra'] Familyt'e1: ents2Label-mention-ngram: to activet!interceding-token ngrams: the ERKt'interceding-token ngrams: ERK pathway .t@e2: trigger-arg-path: binding >prep_to [lemma='ra'] theme:Familyt9e1: trigger-arg-path: bound:Binding >prep_to theme:Familyt'interceding-token ngrams: and M-Ras andtje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='m-ra'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_to [lemma='m-ra'] Gene_or_gene_productt-e2: trigger-arg-path: binding >prep_to Familyt9e2: trigger-arg-path: binding >prep_to [lemma='ra'] themet(interceding-token ngrams: and interferedtTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='ra'] FamilytCe2: trigger-arg-path: binding:Binding >prep_to [lemma='m-ra'] themetGe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to FamilytUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='m-ra'] themet>e1: trigger-arg-path: bound >prep_to [lemma='ra'] theme:Familyt&interceding-token ngrams: with the ERKt5e2: trigger-arg-path: binding:Binding >prep_to FamilytPe2: trigger-arg-path: binding >prep_to [lemma='m-ra'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: to active THEMEt;e2: trigger-arg-path: binding >prep_to [lemma='m-ra'] themet3e1: trigger-arg-path: bound:Binding >prep_to FamilytRe2: trigger-arg-path: binding:Binding >prep_to [lemma='m-ra'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: to active SHAREDt.e2: args2Role-mention-ngram: binding to activet-e1: ents2Label-mention-ngram: bound to activet7e1: trigger-arg-path: bound >prep_to [lemma='ra'] themetHe2: trigger-arg-path: binding:Binding >prep_to [lemma='ra'] theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='ra'] FamilytMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='m-ra'] themet$interceding-token ngrams: interferedtFe1: trigger-arg-path: bound:Binding >prep_to [lemma='ra'] theme:Familyt)interceding-token ngrams: the ERK pathwayt.interceding-token ngrams: M-Ras and interferedtGe2: trigger-arg-path: bound:Binding >dobj >prep_of Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] theme:Gene_or_gene_producttOe1: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] Gene_or_gene_productt?e2: trigger-arg-path: bound >dobj >prep_of Gene_or_gene_producttXe1: trigger-arg-path: binding:Binding >prep_to [lemma='r-ra'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='r-ra'] theme:Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] themetne2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='form'] >prep_of [lemma='r-ra'] Gene_or_gene_productt;e1: trigger-arg-path: binding >prep_to [lemma='r-ra'] themet*interceding-token ngrams: specific for thetPe1: trigger-arg-path: Binding >prep_to [lemma='r-ra'] theme:Gene_or_gene_producttJe1: trigger-arg-path: Binding >prep_to [lemma='r-ra'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] themet*interceding-token ngrams: and specific fort_e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='form'] >prep_of [lemma='r-ra'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] themet@e1: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] themetge1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] theme:Gene_or_gene_producttCe1: trigger-arg-path: binding:Binding >prep_to [lemma='r-ra'] themet]e2: trigger-arg-path: bound >dobj [lemma='form'] >prep_of [lemma='r-ra'] Gene_or_gene_producttjtrigger-to-trigger-path: e1:binding:Binding advcl [lemma='bind'] e2:bound:Bindingt8e1: trigger-arg-path: Binding >nn [lemma='rlip76'] themetee2: trigger-arg-path: bound:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='r-ra'] Gene_or_gene_productt=interceding-tokens-full-span: was direct and specific for thetGe1: trigger-arg-path: binding >nn [lemma='rlip76'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] theme:Gene_or_gene_producttce2: trigger-arg-path: bound >dobj [lemma='form'] >prep_of [lemma='r-ra'] theme:Gene_or_gene_productt0e2: trigger-arg-path: bound >dobj >prep_of themet$interceding-token ngrams: direct andtMe2: trigger-arg-path: bound:Binding >dobj >prep_of theme:Gene_or_gene_productt;e1: trigger-arg-path: Binding >prep_to [lemma='r-ra'] themetNe2: trigger-arg-path: bound >dobj [lemma='form'] >prep_of [lemma='r-ra'] themet&interceding-token ngrams: specific fort&interceding-token ngrams: and specifictMe1: trigger-arg-path: binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: bound form oftRe1: trigger-arg-path: binding:Binding >prep_to [lemma='r-ra'] Gene_or_gene_productt8e2: trigger-arg-path: bound:Binding >dobj >prep_of themetUe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='r-ra'] themetee2: trigger-arg-path: Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] theme:Gene_or_gene_productt$interceding-token ngrams: was directt*e2: args2Role-mention-ngram: form of THEMEt'shortest-path: advcl >nsubjtPe2: trigger-arg-path: Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] themetVe2: trigger-arg-path: bound:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] themetUe1: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='r-ra'] theme:Gene_or_gene_producttgshortest-path: advcl [lemma='bind'] >nsubj [lemma='gtp']tMe1: trigger-arg-path: Binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt(interceding-token ngrams: was direct andt+e2: ents2Label-mention-ngram: bound form oftve2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] Gene_or_gene_producttJe1: trigger-arg-path: binding >prep_to [lemma='r-ra'] Gene_or_gene_producttGe1: trigger-arg-path: Binding >nn [lemma='rlip76'] Gene_or_gene_productt=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT bound formtPe1: trigger-arg-path: binding >prep_to [lemma='r-ra'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] Gene_or_gene_producttJtrigger-to-trigger-path: e1:binding:Binding advcl e2:bound:Bindingt8e1: trigger-arg-path: binding >nn [lemma='rlip76'] themette2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='form'] >prep_of [lemma='r-ra'] theme:Gene_or_gene_producttEe2: trigger-arg-path: bound >dobj >prep_of theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: bound formt-e2: args2Role-mention-ngram: THEME bound formtke2: trigger-arg-path: bound:Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: bound formtde1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='r-ra'] Gene_or_gene_productt_e2: trigger-arg-path: Binding >dobj [lemma='form'] >prep_of [lemma='r-ra'] Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='r-ra'] themet-interceding-token ngrams: direct and specifict%e2: args2Role-mention-ngram: RalGDS ,tee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] themet"e2: args2Role-mention-ngram: NORE1tGe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='r-ra'] themetLe2: trigger-arg-path: bind prep_to >nn Familyt*e2: ents2Label-mention-ngram: PI3-kinase ,t7e2: trigger-arg-path: Binding >prep_to >nn theme:Familyt6CSSPATH: ROOT  ++ ROOT >prep_from >prep_such_as >rcmodtNe2: trigger-arg-path: Binding >prep_to [lemma='member'] >nn [lemma='ra'] themet1e2: trigger-arg-path: Binding >prep_to >nn Familyt(e2: ents2Label-mention-ngram: PI3-kinaset%e2: args2Role-mention-ngram: multiplet9e1: trigger-arg-path: binds >nsubj [lemma='rlip76'] themet-interceding-token ngrams: closely related RastOe2: trigger-arg-path: Binding dobj [lemma='r-ra'] themetKe2: trigger-arg-path: bind >prep_to [lemma='member'] >nn [lemma='ra'] themetIe2: trigger-arg-path: Binding prep_to >nn themet#e2: ents2Label-mention-ngram: NORE1t;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT , RalGDSt\e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='r-ra'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] theme:Familyt(e2: ents2Label-mention-ngram: , RalGDS ,t3interceding-token ngrams: This distinguishes RLIP76t&e2: ents2Label-mention-ngram: , RalGDStSe2: trigger-arg-path: bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] themet+e2: args2Role-mention-ngram: THEME , RalGDStTe2: trigger-arg-path: bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] Familyt-e2: ents2Label-mention-ngram: multiple FAMILYt(interceding-token ngrams: H-Ras or Rap-1t%interceding-token ngrams: the closelyt^e2: trigger-arg-path: lemmatizedTrigger=bind prep_to >nn themetVe1: trigger-arg-path: binds:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt&e2: ents2Label-mention-ngram: RalGDS ,tfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_to >nn theme:Familyt-interceding-token ngrams: the closely relatedtde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='r-ra'] theme:Gene_or_gene_producttMe1: trigger-arg-path: Binding >dobj [lemma='r-ra'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: , RalGDS ,t)interceding-token ngrams: closely relatedt!interceding-token ngrams: Rap-1 .tXe2: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='rlip76'] Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rlip76'] themet)interceding-token ngrams: not the closelytde2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='member'] >nn [lemma='ra'] theme:FamilytKe1: trigger-arg-path: binds >dobj [lemma='r-ra'] theme:Gene_or_gene_productt6e1: trigger-arg-path: binds >dobj [lemma='r-ra'] themet7e2: trigger-arg-path: bind nsubj [lemma='rlip76'] Gene_or_gene_producttLe2: trigger-arg-path: bind >prep_to [lemma='member'] >nn [lemma='ra'] Familyt/interceding-token ngrams: RLIP76 from effectorstVe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='r-ra'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rlip76'] themet1e2: ents2Label-mention-ngram: RalGDS , PI3-kinasetJe1: trigger-arg-path: Binding >nsubj [lemma='rlip76'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='rlip76'] Gene_or_gene_productt6e2: trigger-arg-path: bind:Binding >prep_to >nn Familyt$interceding-token ngrams: or Rap-1 .t.e2: args2Role-mention-ngram: to multiple THEMEt3interceding-token ngrams: distinguishes RLIP76 fromt)e2: args2Role-mention-ngram: that bind totOe2: trigger-arg-path: Binding >prep_to [lemma='member'] >nn [lemma='ra'] Familyt?interceding-tokens-full-span: , but not the closely related Ras proteins H-Ras or Rap-1 . This distinguishes RLIP76 from effectors such astUe2: trigger-arg-path: Binding >prep_to [lemma='member'] >nn [lemma='ra'] theme:Familyt)e2: ents2Label-mention-ngram: , and NORE1t(interceding-token ngrams: proteins H-RastZe2: trigger-arg-path: bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] theme:Familyt&e2: args2Role-mention-ngram: and NORE1tFe2: trigger-arg-path: bind prep_to [lemma='member'] >nn [lemma='ra'] Familyt4e2: trigger-arg-path: bind >prep_to >nn theme:Familytfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='member'] >nn [lemma='ra'] Familyt0e2: ents2Label-mention-ngram: to multiple FAMILYt+interceding-token ngrams: effectors such ast%interceding-token ngrams: RLIP76 fromt'e2: ents2Label-mention-ngram: that bindt^e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='r-ra'] Gene_or_gene_producttNe1: trigger-arg-path: binds >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: NORE1 that bindt+interceding-token ngrams: proteins H-Ras ortEe1: trigger-arg-path: binds >dobj [lemma='r-ra'] Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to >nn theme:Familyt.interceding-token ngrams: distinguishes RLIP76t.e2: ents2Label-mention-ngram: PI3-kinase , andt?e2: trigger-arg-path: bind:Binding nsubj [lemma='rlip76'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding nsubj [lemma='rlip76'] themet-interceding-token ngrams: from effectors suchtRe2: trigger-arg-path: bind >prep_to [lemma='member'] >nn [lemma='ra'] theme:Familyt+e2: args2Role-mention-ngram: , PI3-kinase ,t0e2: args2Role-mention-ngram: RalGDS , PI3-kinaset$e2: ents2Label-mention-ngram: RalGDSt)e2: ents2Label-mention-ngram: to multipletAe1: trigger-arg-path: binds:Binding >nsubj [lemma='rlip76'] themetMe1: trigger-arg-path: binds:Binding >dobj [lemma='r-ra'] Gene_or_gene_producttPe1: trigger-arg-path: Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt,e2: ents2Label-mention-ngram: , PI3-kinase ,t(e2: args2Role-mention-ngram: , and NORE1t>e1: trigger-arg-path: binds:Binding >dobj [lemma='r-ra'] themet@e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to >nn Familyt"interceding-token ngrams: or Rap-1tPe1: trigger-arg-path: binds:Binding >nsubj [lemma='rlip76'] Gene_or_gene_productt%interceding-token ngrams: related Rast.e2: trigger-arg-path: bind >prep_to >nn Familyt.e2: ents2Label-mention-ngram: bind to multiplet]e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='member'] >nn [lemma='ra'] themet&e2: args2Role-mention-ngram: that bindt&interceding-token ngrams: Rap-1 . Thist interceding-token ngrams: RLIP76tGe1: trigger-arg-path: Binding >dobj [lemma='r-ra'] Gene_or_gene_productt(interceding-token ngrams: from effectorstMe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binds GENE_OR_GENE_PRODUCTt-e2: args2Role-mention-ngram: PI3-kinase , andt(e2: ents2Label-mention-ngram: NORE1 thatt(interceding-token ngrams: effectors sucht8e1: trigger-arg-path: Binding >dobj [lemma='r-ra'] themetTe2: trigger-arg-path: bind:Binding dobj [lemma='r-ra'] theme:Gene_or_gene_producttNe2: trigger-arg-path: bind:Binding prep_to >nn theme:FamilytYe1: trigger-arg-path: bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] Gene_or_gene_productt'interceding-token ngrams: coiled coil ,t"interceding-token ngrams: , unliket#interceding-token ngrams: to form at]e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: RBD didt.interceding-token ngrams: unlike the ubiquitint'interceding-token ngrams: coil , unliket interceding-token ngrams: form atee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='r-ra'] theme:Gene_or_gene_productt&e1: trigger-arg-path: bind >nsubj Sitet)e1: ents2Label-mention-ngram: RBD did nott(interceding-token ngrams: common to RBDst$interceding-token ngrams: unlike thet#interceding-token ngrams: common tot?e2: trigger-arg-path: interacts >prep_with [lemma='r-ra'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='r-ra'] themet'interceding-token ngrams: the ubiquitint,interceding-token ngrams: the ubiquitin foldtJe2: trigger-arg-path: Binding >nsubj [lemma='rlip76'] Gene_or_gene_productt!interceding-token ngrams: the RBDt%e1: args2Role-mention-ngram: SITE didt$interceding-token ngrams: the RBD istPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='r-ra'] themet.e1: trigger-arg-path: bind:Binding >nsubj sitet interceding-token ngrams: coil ,tnsubj [lemma='rbd'] Sitet#interceding-token ngrams: predictedt interceding-token ngrams: unliket%interceding-token ngrams: fold commontLe2: trigger-arg-path: Binding >prep_with [lemma='r-ra'] Gene_or_gene_productt+e1: trigger-arg-path: bind >nsubj site:SitetRe2: trigger-arg-path: interacts >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt4e1: trigger-arg-path: bind >nsubj [lemma='rbd'] sitetke1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] Gene_or_gene_productt interceding-token ngrams: coiledt(interceding-token ngrams: fold common tot#interceding-token ngrams: , the RBDtRe1: trigger-arg-path: bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] themetNe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] themet+e1: args2Role-mention-ngram: THEME SITE didt.e1: trigger-arg-path: bind:Binding >nsubj Sitetae1: trigger-arg-path: bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] Gene_or_gene_productt"interceding-token ngrams: a coiledt#interceding-token ngrams: to RBDs ,tinterceding-token ngrams: foldtinterceding-token ngrams: coilt&interceding-token ngrams: predicted totqe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] theme:Gene_or_gene_productt&interceding-token ngrams: is predictedt interceding-token ngrams: RBD istVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] themetGe2: trigger-arg-path: interacts:Binding >prep_with [lemma='r-ra'] themetXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='r-ra'] themet(interceding-token ngrams: ubiquitin foldtRe2: trigger-arg-path: Binding >prep_with [lemma='r-ra'] theme:Gene_or_gene_producttVe2: trigger-arg-path: interacts:Binding >prep_with [lemma='r-ra'] Gene_or_gene_productt4e1: trigger-arg-path: bind >nsubj [lemma='rbd'] Sitetinterceding-token ngrams: RBDst,e1: ents2Label-mention-ngram: SHARED RBD didt?interceding-tokens-full-span: . Indeed , the RBD is predicted to form a coiled coil , unlike the ubiquitin fold common to RBDs , suggesting thatt;e2: trigger-arg-path: Binding >nsubj [lemma='rlip76'] themetTe2: trigger-arg-path: interacts >prep_with [lemma='r-ra'] theme:Gene_or_gene_producttLe2: trigger-arg-path: interacts >nsubj [lemma='rlip76'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] Gene_or_gene_productt=e2: trigger-arg-path: interacts >nsubj [lemma='rlip76'] themet\e2: trigger-arg-path: interacts:Binding >prep_with [lemma='r-ra'] theme:Gene_or_gene_productt'interceding-token ngrams: form a coiledtEe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rlip76'] themet)interceding-token ngrams: is predicted tot\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] themetZe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt+interceding-token ngrams: predicted to formtPe2: trigger-arg-path: Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt interceding-token ngrams: RBDs ,tACSSPATH: ROOT >prep_with >rcmod ++ ROOT >prep_unlike >vmod >ccomptce2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] theme:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='r-ra'] Gene_or_gene_productt+interceding-token ngrams: RBDs , suggestingtde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] themet&interceding-token ngrams: Indeed , thet*interceding-token ngrams: RBD is predictedtMe1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] themet(e1: ents2Label-mention-ngram: SHARED RBDt,e1: ents2Label-mention-ngram: bind to FAMILYtNe2: trigger-arg-path: interacts >prep_with [lemma='r-ra'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='r-ra'] Gene_or_gene_productt%interceding-token ngrams: coiled coilt3e1: trigger-arg-path: bind:Binding >nsubj site:Sitet/interceding-token ngrams: ubiquitin fold commont!interceding-token ngrams: to RBDstse1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] Gene_or_gene_producttnsubj [lemma='rbd'] sitetbe1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] theme:Gene_or_gene_productt\e1: trigger-arg-path: Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] Gene_or_gene_producttJe1: trigger-arg-path: bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] themet&interceding-token ngrams: , unlike thet_e1: trigger-arg-path: bind >nsubj [lemma='rbd'] >nn [lemma='rlip76'] theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: SITE did nott9e1: trigger-arg-path: bind >nsubj [lemma='rbd'] site:Sitet&e1: trigger-arg-path: bind >nsubj sitet'interceding-token ngrams: a coiled coiltke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_producttAe1: trigger-arg-path: bind:Binding >nsubj [lemma='rbd'] site:Sitetme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='r-ra'] theme:Gene_or_gene_producttTe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rlip76'] Gene_or_gene_producttge1: trigger-arg-path: bind:Binding >nsubj [lemma='rbd'] >nn [lemma='rlip76'] theme:Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_of [lemma='dock180'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >vmod >advcl >prep_in controller:Gene_or_gene_producttSe2: trigger-arg-path: Binding >prep_of [lemma='rac-gef'] theme:Gene_or_gene_producttFe1: trigger-arg-path: mediated >nsubj >vmod >advcl >prep_in controllertWe2: trigger-arg-path: recruitment >prep_of [lemma='dock180'] theme:Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rac-gef'] Gene_or_gene_producttQe2: trigger-arg-path: recruitment >prep_of [lemma='dock180'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rac-gef'] themetGe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT mediated recruitmentt2e1: ents2Label-mention-ngram: mediated recruitmentt?e1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controller:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rac-gef'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rac-gef'] themet.e1: ents2Label-mention-ngram: Rac-GEF , SHAREDtZe1: trigger-arg-path: mediated:Positive_regulation >nsubj >vmod >advcl >prep_in controllert\e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='dock180'] themetfe1: trigger-arg-path: Positive_regulation >nsubj >vmod >advcl >prep_in controller:Gene_or_gene_producttJe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rac-gef'] themetQe2: trigger-arg-path: recruitment >prep_of [lemma='rac-gef'] Gene_or_gene_producttde1: trigger-arg-path: mediated:Positive_regulation >nsubj >vmod >advcl >prep_in Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] Gene_or_gene_productt>e2: trigger-arg-path: Binding >prep_of [lemma='dock180'] themetWe2: trigger-arg-path: recruitment >prep_of [lemma='rac-gef'] theme:Gene_or_gene_producttYe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='dock180'] Gene_or_gene_productt'e1: ents2Label-mention-ngram: Rac-GEF ,t?e1: trigger-arg-path: mediated >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >vmod >advcl >prep_in controllertTe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='dock180'] themet8e2: ents2Label-mention-ngram: the GENE_OR_GENE_PRODUCT ,tae1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >vmod >advcl >prep_in Gene_or_gene_producttJe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='dock180'] themet?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controllert?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: recruitment of thet%e1: ents2Label-mention-ngram: Rac-GEFt)e1: ents2Label-mention-ngram: the Rac-GEFt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj >vmod >advcl >prep_in Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controllert?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] Gene_or_gene_producttoe1: trigger-arg-path: mediated:Positive_regulation >nsubj >vmod >advcl >prep_in controller:Gene_or_gene_productt?shortest-path: dobj [lemma='recruitment']tie2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='dock180'] theme:Gene_or_gene_productt?e1: trigger-arg-path: mediated >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controllertYe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rac-gef'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >vmod >advcl >prep_in controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rac-gef'] theme:Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj >vmod >advcl >prep_in controllertBe2: trigger-arg-path: recruitment >prep_of [lemma='rac-gef'] themetqe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='dock180'] theme:Gene_or_gene_productt?e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controllertBe2: trigger-arg-path: recruitment >prep_of [lemma='dock180'] themetMe2: trigger-arg-path: Binding >prep_of [lemma='dock180'] Gene_or_gene_productt1shortest-path: dobjt_e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='dock180'] theme:Gene_or_gene_productt5e1: ents2Label-mention-ngram: mediated recruitment oft?e1: trigger-arg-path: mediated >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controller:Gene_or_gene_productt/e2: args2Role-mention-ngram: recruitment of thet[e1: trigger-arg-path: mediated >nsubj >vmod >advcl >prep_in controller:Gene_or_gene_productt[e1: trigger-arg-path: Positive_regulation >nsubj >vmod >advcl >prep_in Gene_or_gene_producttPe1: trigger-arg-path: mediated >nsubj >vmod >advcl >prep_in Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rac-gef'] theme:Gene_or_gene_productt?e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controller:Gene_or_gene_productt?e1: trigger-arg-path: mediated:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: recruitment of thet+e1: ents2Label-mention-ngram: the Rac-GEF ,t?e1: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controller:Gene_or_gene_productt,e1: ents2Label-mention-ngram: of the Rac-GEFt?e1: trigger-arg-path: lemmatizedTrigger=mediate >nsubj [lemma='study'] >vmod [lemma='implicate'] >advcl [lemma='implicate'] >prep_in [lemma='ARNO'] controllertktrigger-to-trigger-path: e1:mediated:Positive_regulation >dobj [lemma='recruitment'] e2:recruitment:Bindingtke2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='dock180'] Gene_or_gene_productt_e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rac-gef'] theme:Gene_or_gene_productt(e2: args2Role-mention-ngram: the THEME ,tUtrigger-to-trigger-path: e1:mediated:Positive_regulation >dobj e2:recruitment:BindingtMe2: trigger-arg-path: Binding >prep_of [lemma='rac-gef'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='dock180'] Gene_or_gene_producttQe1: trigger-arg-path: Positive_regulation >nsubj >vmod >advcl >prep_in controllert>e2: trigger-arg-path: Binding >prep_of [lemma='rac-gef'] themetQe1: trigger-arg-path: interact >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt1e1: ents2Label-mention-ngram: the closely relatedt(interceding-token ngrams: relative R-Rast1interceding-token ngrams: authentic effector witht,e1: args2Role-mention-ngram: a GTP dependentt2e2: trigger-arg-path: Binding >prep_to >amod themet;e1: ents2Label-mention-ngram: isotypes GENE_OR_GENE_PRODUCTt-interceding-token ngrams: with relative R-Rast_e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] theme:Gene_or_gene_producttJe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] Gene_or_gene_producttSe1: trigger-arg-path: interact >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt(interceding-token ngrams: by functioningt)e1: ents2Label-mention-ngram: related Rast*interceding-token ngrams: and migration bytWe2: trigger-arg-path: Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] themet&e1: ents2Label-mention-ngram: in a GTPtFe1: trigger-arg-path: interact:Binding >prep_with [lemma='h-ra'] themet*interceding-token ngrams: functioning as at)e1: args2Role-mention-ngram: but does nott&interceding-token ngrams: a cascade oft"interceding-token ngrams: or Rap1Atae2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] Gene_or_gene_productt/CSSPATH: ROOT >ccomp ++ ROOT >prepc_by >prep_astYe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >amod theme:Gene_or_gene_producttGe2: trigger-arg-path: Binding >prep_to >amod theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='h-ra'] themet$interceding-token ngrams: a key linkt$interceding-token ngrams: cascade oft0e1: ents2Label-mention-ngram: dependent manner ,t%e1: args2Role-mention-ngram: isotypestinterceding-token ngrams: Rap1At2e1: ents2Label-mention-ngram: GTP dependent mannert/e1: args2Role-mention-ngram: dependent manner ,tOe2: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] Gene_or_gene_producttte2: trigger-arg-path: binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] theme:Gene_or_gene_productt%e1: args2Role-mention-ngram: manner ,t"e1: ents2Label-mention-ngram: in at:e2: trigger-arg-path: binding:Binding >prep_to >amod themet,interceding-token ngrams: cell spreading andt#e1: args2Role-mention-ngram: mannert&e1: ents2Label-mention-ngram: isotypest0interceding-token ngrams: confirming that RLIP76tIe2: trigger-arg-path: binding:Binding >prep_to >amod Gene_or_gene_productt,interceding-token ngrams: Rap1A , confirmingt[e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >amod Gene_or_gene_productt@e2: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] themetNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] themet*e1: ents2Label-mention-ngram: Ras isotypestSe1: trigger-arg-path: interact:Binding >nsubj [lemma='rlip76'] Gene_or_gene_productt$interceding-token ngrams: GTPases int(e1: ents2Label-mention-ngram: , but doest'interceding-token ngrams: with relativet%interceding-token ngrams: of R-Ras ont.e1: args2Role-mention-ngram: interact with thet&interceding-token ngrams: mediates thet&interceding-token ngrams: migration bytUe1: trigger-arg-path: interact:Binding >prep_with [lemma='h-ra'] Gene_or_gene_productt/e1: args2Role-mention-ngram: Ras isotypes THEMEt#interceding-token ngrams: a cascadet0e1: args2Role-mention-ngram: closely related RastKe1: trigger-arg-path: interact >nsubj [lemma='rlip76'] Gene_or_gene_productt(interceding-token ngrams: functioning astge2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: binds R-Ras intnsubj [lemma='rlip76'] themet-interceding-token ngrams: RLIP76 mediates thet8e2: trigger-arg-path: binding >nn [lemma='rlip76'] themet'e1: args2Role-mention-ngram: R-Ras in at2e1: ents2Label-mention-ngram: related Ras isotypestXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='h-ra'] themetle2: trigger-arg-path: binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: closely relatedt+interceding-token ngrams: on cell spreadingt(e1: args2Role-mention-ngram: related Rast'interceding-token ngrams: specificity .t#interceding-token ngrams: link in atfe2: trigger-arg-path: Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: does not interactt1e1: args2Role-mention-ngram: GTP dependent mannert'e1: args2Role-mention-ngram: , but doestWe2: trigger-arg-path: binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] themet#interceding-token ngrams: RLIP76 ist(e1: ents2Label-mention-ngram: R-Ras in at'interceding-token ngrams: effector witht'interceding-token ngrams: spreading andt&e1: ents2Label-mention-ngram: manner ,t*interceding-token ngrams: of small GTPasest-e1: ents2Label-mention-ngram: a GTP dependentt*interceding-token ngrams: GTPases in whicht%e1: args2Role-mention-ngram: R-Ras int0e1: args2Role-mention-ngram: the closely relatedt#interceding-token ngrams: authentict'interceding-token ngrams: the effect oft!interceding-token ngrams: on cellt+e1: ents2Label-mention-ngram: GTP dependentt+interceding-token ngrams: , confirming thattOe2: trigger-arg-path: binding:Binding >prep_to >amod theme:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt%interceding-token ngrams: functioningt(interceding-token ngrams: cell spreadingt&e1: ents2Label-mention-ngram: R-Ras int$interceding-token ngrams: the effecttVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] themet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='h-ra'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: binds R-Rastae2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >amod theme:Gene_or_gene_productt)e1: args2Role-mention-ngram: manner , butt)interceding-token ngrams: effect of R-Rast-interceding-token ngrams: R-Ras specificity .t&interceding-token ngrams: RLIP76 is ant-interceding-token ngrams: mediates the effectt"interceding-token ngrams: , RLIP76t.e1: ents2Label-mention-ngram: dependent mannert"e1: args2Role-mention-ngram: a GTPt"interceding-token ngrams: relativetfe2: trigger-arg-path: binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] Gene_or_gene_producttinterceding-token ngrams: keyt*e1: ents2Label-mention-ngram: but does nott#e1: ents2Label-mention-ngram: a GTPtqe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] themetYe1: trigger-arg-path: interact:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt!e1: args2Role-mention-ngram: in atMe1: trigger-arg-path: interact >prep_with [lemma='h-ra'] Gene_or_gene_productt4interceding-token ngrams: relative R-Ras specificityt"interceding-token ngrams: key linkt&interceding-token ngrams: , confirmingt$e1: args2Role-mention-ngram: closelytAe2: trigger-arg-path: binding >prep_to >amod Gene_or_gene_productt+e1: args2Role-mention-ngram: isotypes THEMEt%e1: ents2Label-mention-ngram: closelyt&interceding-token ngrams: in a cascadet)e1: ents2Label-mention-ngram: the closelyt>e1: trigger-arg-path: interact >prep_with [lemma='h-ra'] themet?e1: ents2Label-mention-ngram: Ras isotypes GENE_OR_GENE_PRODUCTt)interceding-token ngrams: confirming thatt[e1: trigger-arg-path: interact:Binding >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt/interceding-token ngrams: an authentic effectortSe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >amod Gene_or_gene_productt/e1: ents2Label-mention-ngram: interact with thet!interceding-token ngrams: Rap1A ,t'interceding-token ngrams: R-Ras on cellt_e2: trigger-arg-path: binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] themetGe2: trigger-arg-path: binding >nn [lemma='rlip76'] Gene_or_gene_productt(e1: args2Role-mention-ngram: binds R-Rast2e1: ents2Label-mention-ngram: directly binds R-Rast$e1: args2Role-mention-ngram: relatedt*e1: ents2Label-mention-ngram: manner , butt1e1: args2Role-mention-ngram: related Ras isotypestce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] theme:Gene_or_gene_producttMe2: trigger-arg-path: binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt%e1: ents2Label-mention-ngram: relatedt!interceding-token ngrams: GTPasest.interceding-token ngrams: Furthermore , RLIP76t0interceding-token ngrams: effector with relativet%interceding-token ngrams: key link int$interceding-token ngrams: or Rap1A ,t#interceding-token ngrams: spreadingt.e1: ents2Label-mention-ngram: with the closelyt"e1: args2Role-mention-ngram: R-Rast-e1: args2Role-mention-ngram: dependent mannertLe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to >amod themet#e1: ents2Label-mention-ngram: R-Rast)e1: args2Role-mention-ngram: Ras isotypest,e1: ents2Label-mention-ngram: binds R-Ras intinterceding-tokens-full-span: or Rap1A , confirming that RLIP76 is an authentic effector with relative R-Ras specificity . Furthermore , RLIP76 mediates the effect of R-Ras on cell spreading and migration by functioning as a key link in a cascade of small GTPases in whichtGe2: trigger-arg-path: Binding >nn [lemma='rlip76'] Gene_or_gene_producttle2: trigger-arg-path: Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] theme:Gene_or_gene_producttGe2: trigger-arg-path: binding >prep_to >amod theme:Gene_or_gene_producttDe1: trigger-arg-path: interact:Binding >nsubj [lemma='rlip76'] themetUe2: trigger-arg-path: binding:Binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] theme:Gene_or_gene_producttAe2: trigger-arg-path: Binding >prep_to >amod Gene_or_gene_productt!interceding-token ngrams: link intRe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='rlip76'] themet+interceding-token ngrams: , RLIP76 mediatestne2: trigger-arg-path: binding:Binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='h-ra'] theme:Gene_or_gene_productt*interceding-token ngrams: small GTPases int%interceding-token ngrams: that RLIP76t1interceding-token ngrams: spreading and migrationt(e1: args2Role-mention-ngram: the closelytie2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] themet)interceding-token ngrams: is an authentict"interceding-token ngrams: R-Ras ont*e1: args2Role-mention-ngram: GTP dependentt2interceding-token ngrams: migration by functioningt&interceding-token ngrams: an authentictke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: does not interacttMe2: trigger-arg-path: Binding >nn [lemma='rlip76'] theme:Gene_or_gene_productt1e1: args2Role-mention-ngram: directly binds R-Rast]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rlip76'] Gene_or_gene_productt(interceding-token ngrams: that RLIP76 ist$interceding-token ngrams: confirmingt"interceding-token ngrams: of R-Rast8e2: trigger-arg-path: Binding >nn [lemma='rlip76'] themetxe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] Gene_or_gene_productt+interceding-token ngrams: R-Ras specificityt$e1: ents2Label-mention-ngram: mannert%e1: args2Role-mention-ngram: but doestge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='h-ra'] Gene_or_gene_productt1e1: ents2Label-mention-ngram: closely related Rastinterceding-token ngrams: a keyt,interceding-token ngrams: authentic effectort-e1: args2Role-mention-ngram: with the closelyt,e1: args2Role-mention-ngram: closely relatedtee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rlip76'] Gene_or_gene_productt*interceding-token ngrams: cascade of smallt2e2: trigger-arg-path: binding >prep_to >amod themet"interceding-token ngrams: as a keyt+interceding-token ngrams: by functioning ast&e1: ents2Label-mention-ngram: but doest'interceding-token ngrams: small GTPasest3interceding-token ngrams: specificity . Furthermoret"interceding-token ngrams: mediatest)interceding-token ngrams: RLIP76 mediatestYe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='rlip76'] Gene_or_gene_productt%e1: args2Role-mention-ngram: in a GTPtDe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to >amod themet~e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='capacitate'] >amod [lemma='r-ras'] theme:Gene_or_gene_productt)e1: ents2Label-mention-ngram: appeared tot?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='camkius'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: appeared to promotetbe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='camkius'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: to promote SHAREDtdtrigger-to-trigger-path: e1:promote:Positive_regulation >dobj e2:phosphorylation:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='nadph'] controller:Simple_chemicaltye1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='nadph'] controller:Simple_chemicalt;e1: trigger-arg-path: promote nsubj Simple_chemicaltie1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='nadph'] controllerthe1: trigger-arg-path: Positive_regulation nsubj [lemma='nadph'] Simple_chemicaltke1: trigger-arg-path: promote:Positive_regulation nsubj [lemma='nadph'] controllertoe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='camkius'] controller:Gene_or_gene_producttse1: trigger-arg-path: Positive_regulation nsubj [lemma='nadph'] controller:Simple_chemicalt(e1: args2Role-mention-ngram: appeared totve2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='camkius'] Gene_or_gene_productt2e1: args2Role-mention-ngram: to promote CONTROLLEDt0e1: args2Role-mention-ngram: appeared to promotetme2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='camkius'] controller:Gene_or_gene_producttJe2: trigger-arg-path: Positive_regulation >nn [lemma='camkius'] controllert{e1: trigger-arg-path: promote:Positive_regulation nsubj [lemma='nadph'] controller:Simple_chemicalt_e2: trigger-arg-path: Positive_regulation >nn [lemma='camkius'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=promote nsubj [lemma='nadph'] Simple_chemicaltZe1: trigger-arg-path: promote:Positive_regulation nsubj controller:Simple_chemicalt/e1: args2Role-mention-ngram: promote CONTROLLEDt6e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL appearedtOe1: trigger-arg-path: promote:Positive_regulation nsubj Simple_chemicaltpe1: trigger-arg-path: promote:Positive_regulation nsubj [lemma='nadph'] Simple_chemicaltFe1: trigger-arg-path: promote nsubj controller:Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='camkius'] controllertWe1: trigger-arg-path: promote nsubj [lemma='nadph'] controllert3e1: args2Role-mention-ngram: CONTROLLER appeared totce1: trigger-arg-path: Positive_regulation nsubj [lemma='nadph'] controllert[e2: trigger-arg-path: phosphorylation >nn [lemma='camkius'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: appearedtTe2: trigger-arg-path: Positive_regulation >nn [lemma='camkius'] Gene_or_gene_productt\e1: trigger-arg-path: promote nsubj [lemma='nadph'] Simple_chemicaltae1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='nadph'] Simple_chemicaltXe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='camkius'] controllert0e1: args2Role-mention-ngram: CONTROLLER appearedt&e1: ents2Label-mention-ngram: appearedtPe2: trigger-arg-path: phosphorylation >nn [lemma='camkius'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=promote nsubj controller:Simple_chemicaltushortest-path: xcomp [lemma='promote'] >dobj [lemma='phosphorylation'] >nn [lemma='camkius']t}e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj [lemma='nadph'] controllert5e1: ents2Label-mention-ngram: promote SHARED mediatedtZe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='camkius'] controllert(e1: ents2Label-mention-ngram: to promotet,e1: ents2Label-mention-ngram: promote SHAREDtge1: trigger-arg-path: promote nsubj [lemma='nadph'] controller:Simple_chemicalt~trigger-to-trigger-path: e1:promote:Positive_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtde2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='camkius'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL appeared totMe1: trigger-arg-path: lemmatizedTrigger=promote nsubj Simple_chemicaltle1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation nsubj controller:Simple_chemicalt'e1: args2Role-mention-ngram: to promotetFe2: trigger-arg-path: phosphorylation >nn [lemma='camkius'] controllert?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert3e2: args2Role-mention-ngram: stimulation results int?e2: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familyt3e1: args2Role-mention-ngram: stimulation results int?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familyt4e1: ents2Label-mention-ngram: stimulation results int]e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn controller:Familyt.e2: args2Role-mention-ngram: in PI3K dependentt?e1: trigger-arg-path: phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:FamilytRe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn Familyte1: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] FamilytDe2: trigger-arg-path: Positive_regulation nsubj >nn Familytqe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn controller:Familyt?e2: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert?shortest-path: nn [lemma='receptor']tnsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt0e1: ents2Label-mention-ngram: SHARED stimulationt;e2: args2Role-mention-ngram: CONTROLLER stimulation resultst_e2: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn controller:Familytje2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn controllert?e1: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:FamilytKe1: trigger-arg-path: phosphorylation nsubj >nn controller:Familytfe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn FamilytDe2: trigger-arg-path: phosphorylation nsubj >nn controllert?e2: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt1e1: ents2Label-mention-ngram: stimulation resultstqe1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn controller:Familyt;e1: args2Role-mention-ngram: CONTROLLER stimulation resultst,e1: args2Role-mention-ngram: results in PI3KtKe2: trigger-arg-path: phosphorylation nsubj >nn controller:Familyt-e2: ents2Label-mention-ngram: results in PI3Kt8e2: ents2Label-mention-ngram: SHARED stimulation resultst@e2: trigger-arg-path: phosphorylation nsubj >nn Familyt/e2: ents2Label-mention-ngram: in PI3K dependentt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:FamilytRe1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:FamilytOe1: trigger-arg-path: Positive_regulation nsubj >nn controller:Familyt4e2: ents2Label-mention-ngram: stimulation results int.e1: args2Role-mention-ngram: in PI3K dependentt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] FamilytOe2: trigger-arg-path: Positive_regulation nsubj >nn controller:Familyt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert1e2: ents2Label-mention-ngram: stimulation resultst@e1: trigger-arg-path: phosphorylation nsubj >nn Familyt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] FamilytHe2: trigger-arg-path: Positive_regulation nsubj >nn controllert0e2: ents2Label-mention-ngram: SHARED stimulationt%e2: ents2Label-mention-ngram: in PI3Kt0e1: args2Role-mention-ngram: stimulation resultstVe2: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn controllert-e1: ents2Label-mention-ngram: results in PI3Kt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] FamilytTe2: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn Familyt6e1: args2Role-mention-ngram: PI3K dependent CONTROLLEDt,e2: args2Role-mention-ngram: results in PI3Kt$e1: args2Role-mention-ngram: in PI3Ktnsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert$e2: args2Role-mention-ngram: in PI3Kte1: trigger-arg-path: phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert8e1: ents2Label-mention-ngram: SHARED stimulation resultst_e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn controller:FamilytTe1: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn Familyt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert{e2: trigger-arg-path: phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familytfe2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation nsubj >nn Familyt0e2: args2Role-mention-ngram: stimulation resultst{e1: trigger-arg-path: phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familyt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllertDe1: trigger-arg-path: Positive_regulation nsubj >nn Familyte2: trigger-arg-path: phosphorylation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controllert]e1: trigger-arg-path: lemmatizedTrigger=phosphorylation nsubj >nn controller:Familyt?e1: trigger-arg-path: phosphorylation:Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] controller:Familyt6e2: args2Role-mention-ngram: PI3K dependent CONTROLLEDtXe2: trigger-arg-path: phosphorylation:Positive_regulation nsubj >nn controllert/e1: ents2Label-mention-ngram: in PI3K dependentte2: trigger-arg-path: Positive_regulation nsubj [lemma='stimulation'] >nn [lemma='adenosine'] Familyt/e1: ents2Label-mention-ngram: FAMILY stimulatestle2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='pi3k'] controller:Gene_or_gene_producttMe1: trigger-arg-path: stimulates:Positive_regulation >nsubj controller:FamilytYe1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='receptor'] controllertUe1: trigger-arg-path: Positive_regulation >nsubj [lemma='receptor'] controller:Familyt2e1: args2Role-mention-ngram: CONTROLLER stimulatestQe2: trigger-arg-path: Positive_regulation >nn [lemma='pi3k'] Gene_or_gene_producttCe2: trigger-arg-path: phosphorylation >nn [lemma='pi3k'] controllertEe1: trigger-arg-path: stimulates >nsubj [lemma='receptor'] controllertUe2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='pi3k'] controllert9e1: ents2Label-mention-ngram: stimulates SHARED dependenttNe1: trigger-arg-path: Positive_regulation >nsubj [lemma='receptor'] controllertWe2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='pi3k'] controllertsshortest-path: dobj [lemma='phosphorylation'] >nn [lemma='pi3k']t\e2: trigger-arg-path: Positive_regulation >nn [lemma='pi3k'] controller:Gene_or_gene_producttAe1: trigger-arg-path: stimulates >nsubj [lemma='receptor'] FamilytGe2: trigger-arg-path: Positive_regulation >nn [lemma='pi3k'] controllertFe1: trigger-arg-path: stimulates:Positive_regulation >nsubj controllert]e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='receptor'] controller:Familyt2e1: args2Role-mention-ngram: stimulates CONTROLLEDtUe1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='receptor'] FamilytSe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj Familyt9e1: trigger-arg-path: stimulates >nsubj controller:Familyt2e1: trigger-arg-path: stimulates >nsubj controllert?trigger-to-trigger-path: e1:stimulates:Positive_regulation >dobj [lemma='phosphorylation'] e2:phosphorylation:Positive_regulationtje2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='pi3k'] controller:Gene_or_gene_productt.e1: trigger-arg-path: stimulates >nsubj Familyt^e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj controller:FamilytJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='receptor'] Familytgtrigger-to-trigger-path: e1:stimulates:Positive_regulation >dobj e2:phosphorylation:Positive_regulationt6e1: ents2Label-mention-ngram: FAMILY stimulates SHAREDtMe2: trigger-arg-path: phosphorylation >nn [lemma='pi3k'] Gene_or_gene_productt>e1: ents2Label-mention-ngram: SHARED dependent phosphorylationtJe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj controller:FamilytBe1: trigger-arg-path: stimulates:Positive_regulation >nsubj Familytie2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='pi3k'] controllertLe1: trigger-arg-path: stimulates >nsubj [lemma='receptor'] controller:Familyt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='pi3k'] controller:Gene_or_gene_productt=e1: args2Role-mention-ngram: CONTROLLER stimulates CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj FamilytVe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='receptor'] controllert/e1: ents2Label-mention-ngram: stimulates SHAREDtRe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='receptor'] Familytje1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='receptor'] controllertqe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='receptor'] controller:Familytfe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='receptor'] Familyt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >nn [lemma='pi3k'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >nn [lemma='pi3k'] Gene_or_gene_producttae2: trigger-arg-path: phosphorylation:Positive_regulation >nn [lemma='pi3k'] Gene_or_gene_producttXe2: trigger-arg-path: phosphorylation >nn [lemma='pi3k'] controller:Gene_or_gene_productt`e1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='receptor'] controller:Familyt3e1: ents2Label-mention-ngram: also inhibited SHAREDt?e2: trigger-arg-path: stimulated nsubj [lemma='pten'] Negative_regulationt3e2: ents2Label-mention-ngram: also inhibited SHAREDtJe1: trigger-arg-path: inhibited >nsubj [lemma='pten'] Gene_or_gene_productt;e1: ents2Label-mention-ngram: phosphorylation stimulated bytgtrigger-to-trigger-path: e1:inhibited:Negative_regulation >dobj >vmod e2:stimulated:Positive_regulationtUe2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='pdgf'] controllertKe2: trigger-arg-path: stimulated >agent [lemma='pdgf'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj controlled:Negative_regulationtie1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttTe1: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt?e2: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] Negative_regulationtOe2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controlledt'e1: ents2Label-mention-ngram: by eithertGe2: trigger-arg-path: Positive_regulation nsubj controlledt2e1: ents2Label-mention-ngram: stimulated by eithert,e2: ents2Label-mention-ngram: also inhibitedt?trigger-to-trigger-path: e1:inhibited:Negative_regulation >dobj [lemma='phosphorylation'] >vmod [lemma='stimulate'] e2:stimulated:Positive_regulationt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationtJe2: trigger-arg-path: Positive_regulation >agent [lemma='pdgf'] controllertUe1: trigger-arg-path: inhibited >nsubj [lemma='pten'] controller:Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='pdgf'] controllert?e2: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationtfe2: trigger-arg-path: stimulated:Positive_regulation nsubj controlled:Negative_regulationtVe2: trigger-arg-path: stimulated >agent [lemma='pdgf'] controller:Gene_or_gene_productt>shortest-path: advmod [lemma='also']t6e1: args2Role-mention-ngram: also inhibited CONTROLLEDt>e2: ents2Label-mention-ngram: inhibited SHARED phosphorylationt_e2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='pdgf'] Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='pdgf'] Gene_or_gene_producttRe2: trigger-arg-path: stimulated nsubj controlled:Negative_regulationt)e1: ents2Label-mention-ngram: either PDGFt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] controlledt8e1: ents2Label-mention-ngram: phosphorylation stimulatedtce2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controlled:Negative_regulationtne1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] Negative_regulationtAe2: trigger-arg-path: stimulated >agent [lemma='pdgf'] controllert?e2: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] controlledtje2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='pdgf'] controller:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='pdgf'] controllertTe1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] controllert^e1: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] Negative_regulationt+e1: args2Role-mention-ngram: also inhibitedtXe2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj Negative_regulationt@e1: trigger-arg-path: inhibited >nsubj [lemma='pten'] controllert6e1: args2Role-mention-ngram: CONTROLLER also inhibitedt:e1: ents2Label-mention-ngram: PDGF or GENE_OR_GENE_PRODUCTt,e1: ents2Label-mention-ngram: either PDGF ortye1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttTe2: trigger-arg-path: Positive_regulation >agent [lemma='pdgf'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] Gene_or_gene_productt+e1: ents2Label-mention-ngram: stimulated bytge2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='pdgf'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttPe2: trigger-arg-path: Positive_regulation nsubj Negative_regulationt>e2: trigger-arg-path: stimulated nsubj controlledt?e2: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationt_e2: trigger-arg-path: Positive_regulation >agent [lemma='pdgf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] controlled:Negative_regulationtnsubj [lemma='pten'] controlled:Negative_regulationt?e1: ents2Label-mention-ngram: SHARED phosphorylation stimulatedt%e1: ents2Label-mention-ngram: PDGF ort?e2: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] Negative_regulationt1e2: args2Role-mention-ngram: stimulated by eithertce2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj controlledt{e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='pdgf'] controller:Gene_or_gene_productt"e1: ents2Label-mention-ngram: PDGFtGe2: trigger-arg-path: stimulated nsubj Negative_regulationt,e1: ents2Label-mention-ngram: also inhibitedt1e2: args2Role-mention-ngram: by either CONTROLLERt[e2: trigger-arg-path: stimulated:Positive_regulation nsubj Negative_regulationtJe1: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] controllert;e2: ents2Label-mention-ngram: phosphorylation stimulated bytPe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] controllert'e2: ents2Label-mention-ngram: by eithert2e2: ents2Label-mention-ngram: stimulated by eithert&e2: args2Role-mention-ngram: by eithert>e1: ents2Label-mention-ngram: inhibited SHARED phosphorylationt.e2: args2Role-mention-ngram: either CONTROLLERt[e2: trigger-arg-path: Positive_regulation nsubj controlled:Negative_regulationtye2: trigger-arg-path: stimulated nsubj [lemma='pten'] controlledtRe2: trigger-arg-path: stimulated:Positive_regulation nsubj controlledtle2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj Negative_regulationt3e2: ents2Label-mention-ngram: SHARED also inhibitedt\e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='pdgf'] Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED also inhibitedtde1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] controllert?e2: ents2Label-mention-ngram: SHARED phosphorylation stimulatedt&e2: ents2Label-mention-ngram: in vitrot]e1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt"e1: ents2Label-mention-ngram: vivotIe1: trigger-arg-path: inhibits >nsubj [lemma='pten'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: SHARED dephosphorylates FAKt%e1: ents2Label-mention-ngram: in vivot$e1: args2Role-mention-ngram: in vivot?e2: trigger-arg-path: stimulated >agent [lemma='fn'] controllert'e1: ents2Label-mention-ngram: vitro andt)e2: ents2Label-mention-ngram: vivo and int&e1: ents2Label-mention-ngram: vivo andt)e1: ents2Label-mention-ngram: FAK in vivotIe2: trigger-arg-path: stimulated >agent [lemma='fn'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] controllert(e1: args2Role-mention-ngram: in vivo andtZe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] Gene_or_gene_producttHe2: trigger-arg-path: Positive_regulation >agent [lemma='fn'] controllertye2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: dephosphorylatest5e1: ents2Label-mention-ngram: dephosphorylates FAK int"e2: ents2Label-mention-ngram: vivotTe1: trigger-arg-path: inhibits >nsubj [lemma='pten'] controller:Gene_or_gene_productt$e1: ents2Label-mention-ngram: FAK int5e1: ents2Label-mention-ngram: SHARED dephosphorylatest/e1: args2Role-mention-ngram: vitro and inhibitst2e2: ents2Label-mention-ngram: stimulated by SHAREDt*e1: ents2Label-mention-ngram: in vitro andt/shortest-path: nsubj [lemma='pten'] controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] controllert(e1: args2Role-mention-ngram: FAK in vivot"e1: args2Role-mention-ngram: vitrot*e2: ents2Label-mention-ngram: in vitro andt)e1: args2Role-mention-ngram: and in vitrotee2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] controller:Gene_or_gene_productt e1: args2Role-mention-ngram: FAKt2e1: ents2Label-mention-ngram: dephosphorylates FAKt8e2: ents2Label-mention-ngram: dephosphorylates SHARED int]e2: trigger-arg-path: Positive_regulation >agent [lemma='fn'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: vitro and inhibitst!e1: args2Role-mention-ngram: vivot#e1: args2Role-mention-ngram: FAK intTe2: trigger-arg-path: stimulated >agent [lemma='fn'] controller:Gene_or_gene_productt4e1: args2Role-mention-ngram: dephosphorylates FAK int#e2: ents2Label-mention-ngram: vitrot1e1: args2Role-mention-ngram: dephosphorylates FAKt]e2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='fn'] Gene_or_gene_productt?trigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj [lemma='phosphorylation'] >vmod [lemma='stimulate'] e2:stimulated:Positive_regulationt(e1: args2Role-mention-ngram: vivo and int2e1: ents2Label-mention-ngram: stimulated by SHAREDtSe1: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='pten'] controllert*e1: ents2Label-mention-ngram: and in vitrotagent [lemma='fn'] controller:Gene_or_gene_producttRe2: trigger-arg-path: Positive_regulation >agent [lemma='fn'] Gene_or_gene_producttftrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj >vmod e2:stimulated:Positive_regulationt0e2: ents2Label-mention-ngram: vitro and inhibitst,e2: ents2Label-mention-ngram: SHARED in vivot.e2: ents2Label-mention-ngram: dephosphorylatestagent [lemma='fn'] controllert4e1: args2Role-mention-ngram: and inhibits CONTROLLEDt%e1: args2Role-mention-ngram: vivo andt&e2: ents2Label-mention-ngram: vivo andt)e1: ents2Label-mention-ngram: in vivo andt&e1: args2Role-mention-ngram: vitro andt*e2: ents2Label-mention-ngram: and in vitrot)e1: args2Role-mention-ngram: in vitro andt%e2: ents2Label-mention-ngram: in vivot.e1: ents2Label-mention-ngram: dephosphorylatest%e1: args2Role-mention-ngram: in vitrotne2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] Gene_or_gene_productt5e2: ents2Label-mention-ngram: dephosphorylates SHAREDt?e1: trigger-arg-path: inhibits >nsubj [lemma='pten'] controllert_e2: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttwe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj controlled:Negative_regulationt*e1: args2Role-mention-ngram: stimulated bytOe1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controlledt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] controlledtce1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj controlled:Negative_regulationtfe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] controller:Gene_or_gene_productt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationtWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent controllertee2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] controller:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttUe1: trigger-arg-path: stimulated >agent [lemma='egf'] controller:Gene_or_gene_productt5e2: ents2Label-mention-ngram: SHARED inhibited SHAREDt^e2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] controlledtye1: trigger-arg-path: stimulated nsubj [lemma='pten'] controlledtTe1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] controllert>e1: trigger-arg-path: stimulated nsubj controlledtgtrigger-to-trigger-path: e1:stimulated:Positive_regulation nsubj controlledtFe1: trigger-arg-path: stimulated:Positive_regulation >agent controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationtTe2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] controllertSe1: trigger-arg-path: Positive_regulation >agent [lemma='egf'] Gene_or_gene_producttie2: trigger-arg-path: inhibited:Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] Gene_or_gene_producttUe2: trigger-arg-path: inhibited >nsubj [lemma='pten'] controller:Gene_or_gene_producttMe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent Gene_or_gene_producttle1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] Negative_regulationt5e1: args2Role-mention-ngram: CONTROLLED stimulated byt5e1: args2Role-mention-ngram: stimulated by CONTROLLERt@e2: trigger-arg-path: inhibited >nsubj [lemma='pten'] controllertJe1: trigger-arg-path: stimulated >agent [lemma='egf'] Gene_or_gene_productt?e1: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] controlled:Negative_regulationt?e1: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] controlledt@e1: trigger-arg-path: stimulated >agent [lemma='egf'] controllertZe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] controlledtae1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent Gene_or_gene_producttGe1: trigger-arg-path: stimulated nsubj Negative_regulationt^e1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj Negative_regulationt?trigger-to-trigger-path: e1:stimulated:Positive_regulation nsubj controlled:Negative_regulationtQe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] controllert?e1: trigger-arg-path: lemmatizedTrigger=stimulate nsubj [lemma='pten'] controlled:Negative_regulationtCe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent controllert?e1: trigger-arg-path: stimulated nsubj [lemma='pten'] Negative_regulationt[e1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] Gene_or_gene_producttPe1: trigger-arg-path: Positive_regulation nsubj Negative_regulationt2e1: args2Role-mention-ngram: CONTROLLED stimulatedt?e1: trigger-arg-path: Positive_regulation nsubj [lemma='pten'] Negative_regulationt[e1: trigger-arg-path: stimulated:Positive_regulation nsubj Negative_regulationtagent Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj controlledt^e1: trigger-arg-path: Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_producttIe1: trigger-arg-path: Positive_regulation >agent [lemma='egf'] controllertGe1: trigger-arg-path: stimulated >agent controller:Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent controller:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] controllertie1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_producttPe1: trigger-arg-path: stimulated:Positive_regulation >agent Gene_or_gene_productt[e1: trigger-arg-path: Positive_regulation nsubj controlled:Negative_regulationt?e1: trigger-arg-path: stimulated nsubj [lemma='pten'] controlled:Negative_regulationtJe2: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] controllertPe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='pten'] controllertze1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_producttRe1: trigger-arg-path: stimulated nsubj controlled:Negative_regulationtne2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt2e1: trigger-arg-path: stimulated >agent controllertTe2: trigger-arg-path: Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_producttGe1: trigger-arg-path: Positive_regulation nsubj controlledt[e1: trigger-arg-path: stimulated:Positive_regulation >agent controller:Gene_or_gene_producttJe2: trigger-arg-path: inhibited >nsubj [lemma='pten'] Gene_or_gene_productt?e1: trigger-arg-path: stimulated:Positive_regulation nsubj [lemma='pten'] Negative_regulationt5e1: ents2Label-mention-ngram: SHARED inhibited SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation nsubj [lemma='pten'] Negative_regulationt'interceding-token ngrams: observed thattJinterceding-tokens-full-span: . In this study , we observed that wild-typet@e1: ents2Label-mention-ngram: stimulated by GENE_OR_GENE_PRODUCTt1interceding-token ngrams: observed that wild-typet%interceding-token ngrams: we observedt*CSSPATH: ROOT >advcl >ccomp ++ ROOT >ccompt*interceding-token ngrams: we observed thatt(interceding-token ngrams: that wild-typet'interceding-token ngrams: , we observedtagent [lemma='fn'] Gene_or_gene_producttSe1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='fn'] controllertPe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] controllertZe1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] Gene_or_gene_productt]e1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='fn'] Gene_or_gene_producttHe1: trigger-arg-path: Positive_regulation >agent [lemma='fn'] controllert,e1: ents2Label-mention-ngram: SHARED in vivotye1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] controller:Gene_or_gene_producttIe1: trigger-arg-path: stimulated >agent [lemma='fn'] Gene_or_gene_productt]e1: trigger-arg-path: Positive_regulation >agent [lemma='fn'] controller:Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='fn'] controllert?e1: trigger-arg-path: stimulated >agent [lemma='fn'] controllertTe1: trigger-arg-path: stimulated >agent [lemma='fn'] controller:Gene_or_gene_productt5e1: ents2Label-mention-ngram: dephosphorylates SHAREDtee1: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='fn'] controller:Gene_or_gene_productthe1: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='fn'] controller:Gene_or_gene_productt'e1: ents2Label-mention-ngram: SHARED int!e2: ents2Label-mention-ngram: FAKt5e2: ents2Label-mention-ngram: dephosphorylates FAK int9e2: ents2Label-mention-ngram: SHARED dephosphorylates FAKt$e2: ents2Label-mention-ngram: FAK int)e2: ents2Label-mention-ngram: FAK in vivot2e2: ents2Label-mention-ngram: dephosphorylates FAKtTe2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] controllertie2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_productt@e2: trigger-arg-path: stimulated >agent [lemma='egf'] controllert^e2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='egf'] Gene_or_gene_producttze2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] controllertUe2: trigger-arg-path: stimulated >agent [lemma='egf'] controller:Gene_or_gene_producttJe2: trigger-arg-path: stimulated >agent [lemma='egf'] Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] controller:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='egf'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='egf'] controllertie2: trigger-arg-path: inhibiting:Negative_activation dobj [lemma='factor'] >preconj [lemma='both'] controlled:Generic_entityt'interceding-token ngrams: integrin- andtme1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] controllert#interceding-token ngrams: integrin-t?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] controlled:Generic_entitytke2: trigger-arg-path: inhibiting:Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] Gene_or_gene_producttZe2: trigger-arg-path: inhibiting:Negative_activation dobj >preconj Generic_entityt:e1: args2Role-mention-ngram: CONTROLLER inhibit CONTROLLEDtGe1: trigger-arg-path: Negative_activation >dobj >preconj Generic_entitytIe2: trigger-arg-path: Negative_activation nsubj >prep_of controller:Gene_or_gene_productt$interceding-token ngrams: and growtht4e1: ents2Label-mention-ngram: inhibit GENERIC_ENTITYtoe1: trigger-arg-path: Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] Gene_or_gene_producttne1: trigger-arg-path: inhibit >nsubj [lemma='ability'] >prep_of [lemma='pten'] controller:Gene_or_gene_productt.interceding-token ngrams: MAP kinase signalingt6e2: ents2Label-mention-ngram: SHARED inhibiting FAMILYtKe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn controlled:FamilytWe1: trigger-arg-path: inhibit >dobj [lemma='factor'] >preconj [lemma='both'] controlledtEe2: trigger-arg-path: Negative_activation >dobj >nn controlled:Familytxe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj >preconj Generic_entitytre2: trigger-arg-path: inhibiting:Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] controlled:Familytxe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='factor'] >preconj [lemma='both'] controlled:Generic_entitytfe2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activation'] >nn [lemma='ra'] controlledtre1: trigger-arg-path: Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] controlled:Generic_entitytie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj [lemma='factor'] >vmod [lemma='mediate'] >ccomp [lemma='due'] >prep_to [lemma='PTEN'] >vmod [lemma='inhibit'] e2:inhibiting:Negative_activationt0interceding-token ngrams: growth factor mediatedtpinterceding-tokens-full-span: integrin- and growth factor mediated MAP kinase signaling pathways might be due totUe2: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='activation'] >nn [lemma='ra'] Familyt)interceding-token ngrams: factor mediatedt(interceding-token ngrams: pathways mighttMe1: trigger-arg-path: inhibit >nsubj >prep_of controller:Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >preconj Generic_entityt}e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] controlledt.interceding-token ngrams: integrin- and growthtme2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation nsubj [lemma='ability'] >prep_of [lemma='pten'] controllert?e1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] controller:Gene_or_gene_productt2interceding-token ngrams: signaling pathways mighttZe1: trigger-arg-path: inhibit:Negative_activation >dobj >preconj controlled:Generic_entitytTe2: trigger-arg-path: inhibiting:Negative_activation dobj [lemma='activation'] >nn [lemma='ra'] FamilytYe2: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='activation'] >nn [lemma='ra'] controlledt@e2: trigger-arg-path: inhibiting nsubj >prep_of controller:Gene_or_gene_productt1e2: trigger-arg-path: inhibiting dobj [lemma='activation'] >nn [lemma='ra'] controlled:FamilytTe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj >preconj controlledt^e2: trigger-arg-path: Negative_activation dobj >preconj controlledt/e2: ents2Label-mention-ngram: SHARED inhibitingtdobj >nn controlled:Familyt]e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >preconj controlledt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation dobj [lemma='activation'] >nn [lemma='ra'] controlledtLe1: trigger-arg-path: inhibit:Negative_activation >nsubj >prep_of controllert2e2: args2Role-mention-ngram: CONTROLLER inhibitingtce1: trigger-arg-path: inhibit >nsubj [lemma='ability'] >prep_of [lemma='pten'] Gene_or_gene_productt{trigger-to-trigger-path: e1:inhibit:Negative_activation >dobj >vmod >ccomp >prep_to >vmod e2:inhibiting:Negative_activationtRe1: trigger-arg-path: Negative_activation >dobj >preconj controlled:Generic_entitytSe2: trigger-arg-path: inhibiting >dobj [lemma='activation'] >nn [lemma='ra'] FamilytBe1: trigger-arg-path: inhibit >nsubj >prep_of Gene_or_gene_producttze1: trigger-arg-path: Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ability'] >prep_of [lemma='pten'] Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='factor'] >preconj [lemma='both'] Generic_entityt_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn controlled:Familyt:shortest-path: dobj >vmod >ccomp >prep_tot,e1: ents2Label-mention-ngram: SHARED inhibitt;e1: ents2Label-mention-ngram: SHARED inhibit GENERIC_ENTITYtwe1: trigger-arg-path: inhibit:Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] Gene_or_gene_producttfe1: trigger-arg-path: inhibit >dobj [lemma='factor'] >preconj [lemma='both'] controlled:Generic_entityt+interceding-token ngrams: pathways might betCe1: trigger-arg-path: Negative_activation >dobj >preconj controlledt:e2: trigger-arg-path: Negative_activation >dobj >nn Familythe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj >prep_of Gene_or_gene_producttVe1: trigger-arg-path: inhibit:Negative_activation >nsubj >prep_of Gene_or_gene_producttge1: trigger-arg-path: Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] Generic_entitytFe1: trigger-arg-path: inhibit >dobj >preconj controlled:Generic_entityt1e2: trigger-arg-path: inhibiting >dobj >nn Familytinterceding-token ngrams: MAPtDe2: trigger-arg-path: Negative_activation nsubj [lemma='ability'] >prep_of [lemma='pten'] controllert&interceding-token ngrams: mediated MAPtIe2: trigger-arg-path: inhibiting:Negative_activation >dobj >nn controlledtTe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >nn Familyt*interceding-token ngrams: kinase signalingt-interceding-token ngrams: mediated MAP kinasetie1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='factor'] >preconj [lemma='both'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] Generic_entitytPe2: trigger-arg-path: inhibiting:Negative_activation >dobj >nn controlled:Familyt@e2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >nn Familyt/e2: ents2Label-mention-ngram: inhibiting FAMILYt8e1: trigger-arg-path: inhibit >nsubj >prep_of controllert[e1: trigger-arg-path: inhibit >dobj [lemma='factor'] >preconj [lemma='both'] Generic_entitytEe2: trigger-arg-path: inhibiting:Negative_activation >dobj >nn Familyt5e2: trigger-arg-path: inhibiting >dobj >nn controlledtme2: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='activation'] >nn [lemma='ra'] controlled:Familytle1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj >preconj controlled:Generic_entityt&interceding-token ngrams: might be duet$interceding-token ngrams: MAP kinasetOe2: trigger-arg-path: Negative_activation dobj [lemma='factor'] >preconj [lemma='both'] Generic_entitytke1: trigger-arg-path: inhibit:Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] controlledtKe1: trigger-arg-path: inhibit:Negative_activation >dobj >preconj controlledt^e2: trigger-arg-path: inhibiting:Negative_activation nsubj [lemma='ability'] >prep_of [lemma='pten'] controller:Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] Familytge2: trigger-arg-path: Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] controlled:Familyt-interceding-token ngrams: factor mediated MAPtXe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >preconj controlled:Generic_entityt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] controlled:FamilytFe2: trigger-arg-path: inhibiting nsubj >prep_of controllert;e2: trigger-arg-path: inhibiting dobj [lemma='activation'] >nn [lemma='ra'] Familyt interceding-token ngrams: be duetee1: trigger-arg-path: Negative_activation >nsubj [lemma='ability'] >prep_of [lemma='pten'] controllertze2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='activation'] >nn [lemma='ra'] controlledtYe1: trigger-arg-path: inhibit >nsubj [lemma='ability'] >prep_of [lemma='pten'] controllertde2: trigger-arg-path: lemmatizedTrigger=inhibit dobj [lemma='factor'] >vmod [lemma='mediate'] >ccomp [lemma='due'] >prep_to [lemma='PTEN']tce1: trigger-arg-path: Negative_activation >dobj [lemma='factor'] >preconj [lemma='both'] controlledtMe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj >preconj Generic_entitytOe2: trigger-arg-path: lemmatizedTrigger=inhibit nn theme:Familytke1: trigger-arg-path: lemmatizedTrigger=associate:Binding nn [lemma='egf'] Familyt'interceding-token ngrams: no detectablet?e1: trigger-arg-path: associated >prep_with [lemma='shc'] themet?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] Gene_or_gene_productt4interceding-token ngrams: receptor phosphorylation .t_e1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='shc'] Gene_or_gene_productt1e1: trigger-arg-path: associated nn FamilytZe1: trigger-arg-path: associated:Binding nn [lemma='egf'] Familyt-interceding-token ngrams: and PTEN expressingt/e1: ents2Label-mention-ngram: FAMILY associatedt\e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >nn controller:Gene_or_gene_productt/interceding-token ngrams: PTEN expressing cellstIe1: trigger-arg-path: lemmatizedTrigger=associate:Binding nn themet8interceding-token ngrams: detectable differences betweent&interceding-token ngrams: EGF receptortze2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controllertge1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='shc'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent >nn controllertBe1: trigger-arg-path: lemmatizedTrigger=associate nn Familyt6e2: trigger-arg-path: stimulated >agent >nn controllert,interceding-token ngrams: expressing cells ,tXe1: trigger-arg-path: associated nn [lemma='egf'] theme:Familytce1: trigger-arg-path: lemmatizedTrigger=associate nn [lemma='egf'] FamilytNe1: trigger-arg-path: associated >prep_with [lemma='shc'] Gene_or_gene_producttse2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] Gene_or_gene_productt7CSSPATH: ROOT >nsubj >prep_of >vmod ++ ROOT >dobj >vmodtbe1: trigger-arg-path: lemmatizedTrigger=associate nn [lemma='egf'] themet#interceding-token ngrams: PTEN doestPe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='shc'] themet*interceding-token ngrams: control and PTENt7e1: trigger-arg-path: associated nn theme:FamilytKe2: trigger-arg-path: stimulated >agent >nn controller:Gene_or_gene_productt+interceding-token ngrams: finding that PTENtUe2: trigger-arg-path: stimulated >agent [lemma='binding'] >nn [lemma='fn'] controllert-interceding-token ngrams: differences betweent8e1: trigger-arg-path: associated:Binding nn themetpe2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent >nn controller:Gene_or_gene_productt+interceding-token ngrams: , consistent withtpe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='binding'] >nn [lemma='fn'] Gene_or_gene_productt&interceding-token ngrams: , consistentt.interceding-token ngrams: inhibit EGF receptort0e1: trigger-arg-path: associated nn themetTe2: trigger-arg-path: stimulated:Positive_regulation >agent >nn Gene_or_gene_productt-e1: trigger-arg-path: Binding nn themet~e2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controller:Gene_or_gene_productt?interceding-tokens-full-span: showed no detectable differences between control and PTEN expressing cells , consistent with the finding that PTEN does not inhibit EGF receptor phosphorylation .tee2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent >nn Gene_or_gene_productt5interceding-token ngrams: differences between controlt)interceding-token ngrams: between controlt$interceding-token ngrams: detectablet\e1: trigger-arg-path: associated:Binding >prep_with [lemma='shc'] theme:Gene_or_gene_productt3interceding-token ngrams: no detectable differencest"interceding-token ngrams: and PTENtOe1: trigger-arg-path: Binding nn [lemma='egf'] Familyt_e2: trigger-arg-path: stimulated:Positive_regulation >agent >nn controller:Gene_or_gene_producttGe1: trigger-arg-path: associated:Binding >prep_with [lemma='shc'] themet'interceding-token ngrams: PTEN does nott@e2: trigger-arg-path: stimulated >agent >nn Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='shc'] themetUe1: trigger-arg-path: Binding nn [lemma='egf'] theme:Familyt4e1: trigger-arg-path: Binding nn theme:FamilytAe1: trigger-arg-path: lemmatizedTrigger=associate nn themet_e2: trigger-arg-path: stimulated >agent [lemma='binding'] >nn [lemma='fn'] Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='binding'] >nn [lemma='fn'] controller:Gene_or_gene_productt`e1: trigger-arg-path: associated:Binding nn [lemma='egf'] theme:Familyt^e2: trigger-arg-path: Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controllertQe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >nn Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=associate nn [lemma='egf'] theme:FamilytNe1: trigger-arg-path: Binding nn [lemma='egf'] themetAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also inhibitedtqe1: trigger-arg-path: lemmatizedTrigger=associate:Binding nn [lemma='egf'] theme:Familytme1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='shc'] theme:Gene_or_gene_producttTe1: trigger-arg-path: associated >prep_with [lemma='shc'] theme:Gene_or_gene_productt.e1: trigger-arg-path: Binding nn Familytprep_with [lemma='shc'] themetGe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent >nn controllert6interceding-token ngrams: EGF receptor phosphorylationtfe2: trigger-arg-path: lemmatizedTrigger=stimulate >agent [lemma='binding'] >nn [lemma='fn'] controllert#interceding-token ngrams: that PTENtje1: trigger-arg-path: lemmatizedTrigger=associate:Binding nn [lemma='egf'] themet(interceding-token ngrams: that PTEN doestse2: trigger-arg-path: Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controller:Gene_or_gene_producttJe1: trigger-arg-path: lemmatizedTrigger=associate:Binding nn FamilytJe2: trigger-arg-path: stimulated:Positive_regulation >agent >nn controllertQe1: trigger-arg-path: associated nn [lemma='egf'] themetHe1: trigger-arg-path: lemmatizedTrigger=associate nn theme:FamilytVe1: trigger-arg-path: associated:Binding >prep_with [lemma='shc'] Gene_or_gene_productt)interceding-token ngrams: PTEN expressingtQe1: trigger-arg-path: Binding >prep_with [lemma='shc'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='shc'] theme:Gene_or_gene_producttKe1: trigger-arg-path: Binding >prep_with [lemma='shc'] Gene_or_gene_productt-interceding-token ngrams: between control andt0interceding-token ngrams: detectable differencesthe2: trigger-arg-path: Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] Gene_or_gene_productt%interceding-token ngrams: control andt4e1: ents2Label-mention-ngram: FAMILY associated withtRe1: trigger-arg-path: associated nn [lemma='egf'] Familyt.interceding-token ngrams: showed no detectablet%interceding-token ngrams: differencest9e1: trigger-arg-path: associated:Binding nn Familyt2interceding-token ngrams: receptor phosphorylationt?e1: trigger-arg-path: associated:Binding nn theme:Familyt#interceding-token ngrams: showed notje2: trigger-arg-path: stimulated >agent [lemma='binding'] >nn [lemma='fn'] controller:Gene_or_gene_producttie2: trigger-arg-path: stimulated:Positive_regulation >agent [lemma='binding'] >nn [lemma='fn'] controllertYe1: trigger-arg-path: associated:Binding nn [lemma='egf'] themet+e2: args2Role-mention-ngram: also inhibitedt6e2: args2Role-mention-ngram: also inhibited CONTROLLEDt,CSSPATH: ROOT >nsubj >prep_of >vmod ++ ROOT t6e2: args2Role-mention-ngram: CONTROLLER also inhibitedtXe2: trigger-arg-path: inhibit:Negative_regulation >nsubj controller:Gene_or_gene_productt;shortest-path: dobj >rcmod >dep >nsubjtSe2: trigger-arg-path: inhibit >nsubj [lemma='pten'] controller:Gene_or_gene_producttutrigger-to-trigger-path: e1:associated:Binding dobj >rcmod >dep e2:inhibit:Negative_regulationt3e2: trigger-arg-path: inhibit >dobj Phosphorylationt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT does nott?trigger-to-trigger-path: e1:associated:Binding dobj [lemma='difference'] >rcmod [lemma='consistent'] >dep [lemma='inhibit'] e2:inhibit:Negative_regulationt>e2: trigger-arg-path: inhibit >dobj controlled:Phosphorylationt?interceding-tokens-full-span: showed no detectable differences between control and PTEN expressing cells , consistent with the finding thattle2: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtRe2: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='pten'] controllertBe2: trigger-arg-path: inhibit:Negative_regulation >dobj controlledtae2: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='phosphorylation'] PhosphorylationtHe2: trigger-arg-path: inhibit >nsubj [lemma='pten'] Gene_or_gene_producttMe2: trigger-arg-path: inhibit >dobj [lemma='phosphorylation'] Phosphorylationtge2: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='pten'] controller:Gene_or_gene_producttdobj [lemma='phosphorylation'] controlledtGe2: trigger-arg-path: inhibit:Negative_regulation >dobj Phosphorylationt.e2: ents2Label-mention-ngram: does not inhibittMe2: trigger-arg-path: inhibit:Negative_regulation >nsubj Gene_or_gene_productt?shortest-path: dobj [lemma='difference'] >rcmod [lemma='consistent'] >dep [lemma='inhibit'] >nsubj [lemma='pten']t>e2: trigger-arg-path: inhibit >nsubj [lemma='pten'] controllertXe2: trigger-arg-path: inhibit >dobj [lemma='phosphorylation'] controlled:PhosphorylationtRe2: trigger-arg-path: inhibit:Negative_regulation >dobj controlled:PhosphorylationtCe2: trigger-arg-path: inhibit:Negative_regulation >nsubj controllert\e2: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='pten'] Gene_or_gene_productt7e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT doest\e2: trigger-arg-path: inhibit:Negative_regulation >dobj [lemma='phosphorylation'] controlledt-e2: args2Role-mention-ngram: does not inhibitt0e2: ents2Label-mention-ngram: not inhibit SHAREDt3e2: args2Role-mention-ngram: not inhibit CONTROLLEDt?e2: trigger-arg-path: binds:Binding >nsubj [lemma='r-ra'] themetPe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='r-ra'] themetIe1: trigger-arg-path: activates >dobj [lemma='pi3k'] Gene_or_gene_productt*e1: args2Role-mention-ngram: PI3K in vitrot_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='r-ra'] Gene_or_gene_productt9e2: trigger-arg-path: Binding >nsubj [lemma='r-ra'] themetPe2: trigger-arg-path: Binding >prep_to [lemma='pi3k'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: has been showntTe2: trigger-arg-path: binds:Binding >nsubj [lemma='r-ra'] theme:Gene_or_gene_producttHe1: trigger-arg-path: Positive_activation >nsubj [lemma='it'] controllertFe2: trigger-arg-path: binds >nsubj [lemma='r-ra'] Gene_or_gene_producttMe1: trigger-arg-path: activates >nsubj [lemma='it'] controller:Generic_entityt;e2: trigger-arg-path: Binding >prep_to [lemma='pi3k'] themet'e1: args2Role-mention-ngram: to PI3K intTshortest-path: ccomp [lemma='bind'] >nsubj [lemma='r-ra']t@e1: trigger-arg-path: activates >nsubj controller:Generic_entitytHe2: trigger-arg-path: Binding >nsubj [lemma='r-ra'] Gene_or_gene_productt+e1: args2Role-mention-ngram: R-Ras binds tot]e1: trigger-arg-path: activates:Positive_activation >dobj [lemma='pi3k'] Gene_or_gene_productt'shortest-path: ccomp >nsubjtNe2: trigger-arg-path: binds >prep_to [lemma='pi3k'] theme:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pi3k'] controlled:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3k'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='r-ra'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] Generic_entitytee1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pi3k'] controlled:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj controller:Generic_entitytae1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] controller:Generic_entityt]e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='r-ra'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj Generic_entitytce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] controllert0e1: args2Role-mention-ngram: CONTROLLER has beentIe1: trigger-arg-path: activates:Positive_activation >nsubj Generic_entitytFe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj Generic_entityt+e1: ents2Label-mention-ngram: binds to PI3Kt.e1: ents2Label-mention-ngram: shown that R-RastYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3k'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: PI3K int$e1: args2Role-mention-ngram: PI3K intHe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='r-ra'] themetOe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] controllertytrigger-to-trigger-path: e1:activates:Positive_activation ccomp [lemma='bind'] e2:binds:Bindingt[trigger-to-trigger-path: e1:activates:Positive_activation ccomp e2:binds:Bindingt,e1: ents2Label-mention-ngram: has been shownt7e2: trigger-arg-path: binds >nsubj [lemma='r-ra'] themetge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3k'] theme:Gene_or_gene_producttVe2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3k'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3k'] theme:Gene_or_gene_productt,e1: ents2Label-mention-ngram: R-Ras binds tot,e1: args2Role-mention-ngram: been shown thattWe1: trigger-arg-path: Positive_activation >nsubj [lemma='it'] controller:Generic_entityt^e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] controller:Generic_entityt>e1: trigger-arg-path: activates >nsubj [lemma='it'] controllertee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='r-ra'] theme:Gene_or_gene_productt.e1: ents2Label-mention-ngram: that R-Ras bindstNe2: trigger-arg-path: Binding >nsubj [lemma='r-ra'] theme:Gene_or_gene_productt5e1: args2Role-mention-ngram: and activates CONTROLLEDtNe2: trigger-arg-path: binds:Binding >nsubj [lemma='r-ra'] Gene_or_gene_producttPe2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3k'] Gene_or_gene_productthe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='pi3k'] controlled:Gene_or_gene_producttLe1: trigger-arg-path: Positive_activation >nsubj [lemma='it'] Generic_entitytre1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='it'] controller:Generic_entityt2e1: ents2Label-mention-ngram: and activates SHAREDtRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='pi3k'] themetne1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pi3k'] Gene_or_gene_producttVe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] Generic_entityt'e1: args2Role-mention-ngram: that R-RastRe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='it'] controllert+e1: ents2Label-mention-ngram: PI3K in vitrot$e1: args2Role-mention-ngram: to PI3Kt(e1: ents2Label-mention-ngram: that R-Rast*e1: args2Role-mention-ngram: binds to PI3Kt-e1: args2Role-mention-ngram: shown that R-RastQe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj controller:Generic_entityt)e1: ents2Label-mention-ngram: R-Ras bindst?e1: trigger-arg-path: activates >dobj [lemma='pi3k'] controlledtAe2: trigger-arg-path: binds:Binding >prep_to [lemma='pi3k'] themet5e1: trigger-arg-path: activates >nsubj Generic_entityt1e1: ents2Label-mention-ngram: vitro and activatestIe1: trigger-arg-path: Positive_activation >dobj [lemma='pi3k'] controlledtSe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='pi3k'] controlledt+e1: args2Role-mention-ngram: CONTROLLER hast-e1: args2Role-mention-ngram: that R-Ras bindstPe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pi3k'] controlledtJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='pi3k'] themet%e1: ents2Label-mention-ngram: to PI3Kt-e1: ents2Label-mention-ngram: been shown thattTe1: trigger-arg-path: activates:Positive_activation >nsubj controller:Generic_entitytHe2: trigger-arg-path: binds >prep_to [lemma='pi3k'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='pi3k'] controlledtTe1: trigger-arg-path: activates >dobj [lemma='pi3k'] controlled:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='pi3k'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: shown thattBe1: trigger-arg-path: activates >nsubj [lemma='it'] Generic_entityt9e2: trigger-arg-path: binds >prep_to [lemma='pi3k'] themetSe1: trigger-arg-path: Positive_activation >dobj [lemma='pi3k'] Gene_or_gene_productt(e1: args2Role-mention-ngram: R-Ras bindstLe2: trigger-arg-path: binds >nsubj [lemma='r-ra'] theme:Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='it'] Generic_entitytJe2: trigger-arg-path: Binding >prep_to [lemma='pi3k'] Gene_or_gene_productt(e1: ents2Label-mention-ngram: to PI3K int0e1: args2Role-mention-ngram: vitro and activatest^e1: trigger-arg-path: Positive_activation >dobj [lemma='pi3k'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: shown thattftrigger-to-trigger-path: e1:recruitment:Binding >conj_and [lemma='interaction'] e2:interaction:Bindingt*e1: args2Role-mention-ngram: THEME and itst8e1: args2Role-mention-ngram: subsequent interaction withtVe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_with themetfe1: trigger-arg-path: recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] theme:FamilytCe2: ents2Label-mention-ngram: GENERIC_ENTITY subsequent interactiontXe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rasgrp'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rasgrp'] themetLe1: trigger-arg-path: Binding >prep_of [lemma='rasgrp'] Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] Familytpe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rasgrp'] theme:Gene_or_gene_productt^e1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rasgrp'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >conj_and >prep_with FamilytSe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rasgrp'] themetCe1: trigger-arg-path: recruitment >conj_and >prep_with theme:Familyt4e2: ents2Label-mention-ngram: subsequent interactiontEe1: trigger-arg-path: recruitment:Binding >conj_and >prep_with Familyt9e2: ents2Label-mention-ngram: subsequent interaction withtze1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] FamilytKe1: trigger-arg-path: recruitment:Binding >conj_and >prep_with theme:Familyt`e1: trigger-arg-path: recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] FamilytRe1: trigger-arg-path: Binding >prep_of [lemma='rasgrp'] theme:Gene_or_gene_producttPe1: trigger-arg-path: recruitment >prep_of [lemma='rasgrp'] Gene_or_gene_producttWe1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_with Familyt+e1: args2Role-mention-ngram: its subsequentt?e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] theme:Familytxe1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] theme:FamilytDe1: trigger-arg-path: recruitment:Binding >conj_and >prep_with themet9e2: args2Role-mention-ngram: THEME subsequent interactiontPtrigger-to-trigger-path: e1:recruitment:Binding >conj_and e2:interaction:Bindingthe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rasgrp'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_with theme:Familyt_e1: trigger-arg-path: recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] themetbe1: trigger-arg-path: Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] theme:Familyt=e1: trigger-arg-path: Binding >prep_of [lemma='rasgrp'] themetAe1: trigger-arg-path: recruitment >prep_of [lemma='rasgrp'] themet3e1: args2Role-mention-ngram: subsequent interactiont7e1: args2Role-mention-ngram: its subsequent interactiont8e2: args2Role-mention-ngram: subsequent interaction withthe1: trigger-arg-path: recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] Familyt4e1: ents2Label-mention-ngram: subsequent interactiont:e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT and itstge1: trigger-arg-path: recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] themet-e2: args2Role-mention-ngram: THEME subsequentt]e1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and >prep_with theme:FamilytVe1: trigger-arg-path: recruitment >prep_of [lemma='rasgrp'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rasgrp'] Gene_or_gene_producttne1: trigger-arg-path: recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] theme:FamilytNe1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_with themetje1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rasgrp'] Gene_or_gene_productt8e1: ents2Label-mention-ngram: its subsequent interactiont?e1: trigger-arg-path: Binding >conj_and >prep_with theme:Familyt,e1: ents2Label-mention-ngram: its subsequentt9e1: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT andtIe1: trigger-arg-path: recruitment:Binding >prep_of [lemma='rasgrp'] themet3e2: args2Role-mention-ngram: subsequent interactiont/e1: args2Role-mention-ngram: and its subsequenttOe1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and >prep_with Familyt9e1: ents2Label-mention-ngram: subsequent interaction withtAe1: ents2Label-mention-ngram: recruitment of GENE_OR_GENE_PRODUCTt8e1: trigger-arg-path: Binding >conj_and >prep_with themetye1: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] themet7e2: ents2Label-mention-ngram: GENERIC_ENTITY subsequentt[e1: trigger-arg-path: Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] themet\e1: trigger-arg-path: Binding >conj_and [lemma='interaction'] >prep_with [lemma='ra'] Familyt=e1: trigger-arg-path: recruitment >conj_and >prep_with Familyt0e1: ents2Label-mention-ngram: and its subsequenttconj_and >prep_with themet'e1: args2Role-mention-ngram: subsequenttqe1: trigger-arg-path: lemmatizedTrigger=recruitment >conj_and [lemma='interaction'] >prep_with [lemma='ra'] themet?e2: trigger-arg-path: involved >agent controller:Generic_entitytPe2: trigger-arg-path: lemmatizedTrigger=involve >agent controller:Generic_entityt(e2: args2Role-mention-ngram: involved inte2: ents2Label-mention-ngram: itQe2: trigger-arg-path: involved >agent [lemma='protein'] controller:Generic_entitytJe2: trigger-arg-path: Positive_regulation >agent controller:Generic_entityt&e2: ents2Label-mention-ngram: involvedt0e2: trigger-arg-path: involved >agent controllert"e2: args2Role-mention-ngram: the GtBe2: trigger-arg-path: involved >agent [lemma='protein'] controllert,e2: args2Role-mention-ngram: involved in ERKtre1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controllert?e2: trigger-arg-path: Positive_regulation >agent Generic_entityt e2: args2Role-mention-ngram: PKCtDe2: trigger-arg-path: involved:Positive_regulation >agent controllert$e2: ents2Label-mention-ngram: in ERKt#e2: ents2Label-mention-ngram: the Gtve2: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >agent [lemma='protein'] controller:Generic_entityt/e2: ents2Label-mention-ngram: ERK activation byt e2: args2Role-mention-ngram: G itVe2: trigger-arg-path: involved:Positive_regulation >agent [lemma='protein'] controllertke2: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >agent [lemma='protein'] Generic_entitytge2: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >agent [lemma='protein'] controllert|trigger-to-trigger-path: e1:phosphorylation:Positive_regulation agent Generic_entityt+e2: args2Role-mention-ngram: ERK activationt*e2: args2Role-mention-ngram: also involvedte2: trigger: involvedt,e2: ents2Label-mention-ngram: ERK activationt$e2: ents2Label-mention-ngram: PKC iste2: args2Role-mention-ngram: Gt$e2: ents2Label-mention-ngram: by PKCt/e2: ents2Label-mention-ngram: activation by thet?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controller:Gene_or_gene_productt?e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controller:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=involve >agent [lemma='protein'] controllert.e2: ents2Label-mention-ngram: i GENERIC_ENTITYt^e1: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controllert#e2: args2Role-mention-ngram: in ERKt%e2: ents2Label-mention-ngram: the G it\e2: trigger-arg-path: Positive_regulation >agent [lemma='protein'] controller:Generic_entitytse1: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controller:Gene_or_gene_producttFe2: trigger-arg-path: involved >agent [lemma='protein'] Generic_entitytze1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >agent controllerte2: ents2Label-mention-ngram: Gtle1: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: also involvedt'e2: ents2Label-mention-ngram: by PKC ist?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: by PKC istee2: trigger-arg-path: involved:Positive_regulation >agent [lemma='protein'] controller:Generic_entityt%e2: args2Role-mention-ngram: by the Gt#e2: args2Role-mention-ngram: PKC istWe2: trigger-arg-path: lemmatizedTrigger=involve >agent [lemma='protein'] Generic_entitytpe1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controllertbe2: trigger-arg-path: lemmatizedTrigger=involve >agent [lemma='protein'] controller:Generic_entitytZe2: trigger-arg-path: involved:Positive_regulation >agent [lemma='protein'] Generic_entityt+e2: ents2Label-mention-ngram: SHARED by PKCtQe2: trigger-arg-path: Positive_regulation >agent [lemma='protein'] Generic_entitytAe2: trigger-arg-path: lemmatizedTrigger=involve >agent controllert#e2: args2Role-mention-ngram: by PKCtjtrigger-to-trigger-path: e1:phosphorylation:Positive_regulation prep_of [lemma='raf'] >prep_by [lemma='pkc'] controllert)e2: ents2Label-mention-ngram: PKC is alsot.e2: ents2Label-mention-ngram: also involved intEe2: trigger-arg-path: lemmatizedTrigger=involve >agent Generic_entitytbe1: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controllert+e2: args2Role-mention-ngram: G i CONTROLLERt4e2: trigger-arg-path: involved >agent Generic_entityt)e2: args2Role-mention-ngram: i CONTROLLERtHe2: trigger-arg-path: involved:Positive_regulation >agent Generic_entityt.e2: args2Role-mention-ngram: in ERK activationt&e2: ents2Label-mention-ngram: by the Gt)e2: ents2Label-mention-ngram: involved int.e2: ents2Label-mention-ngram: is also involvedt$e2: args2Role-mention-ngram: the G it?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] Gene_or_gene_productt-e2: args2Role-mention-ngram: also involved inte2: args2Role-mention-ngram: it/e2: ents2Label-mention-ngram: in ERK activationtwe1: trigger-arg-path: Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] controller:Gene_or_gene_producttSe2: trigger-arg-path: involved:Positive_regulation >agent controller:Generic_entityt!e2: ents2Label-mention-ngram: G it(e2: args2Role-mention-ngram: PKC is alsot!e2: ents2Label-mention-ngram: PKCtde2: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >agent controller:Generic_entityt%e2: args2Role-mention-ngram: involvedt|e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: G i GENERIC_ENTITYt.e2: args2Role-mention-ngram: CONTROLLED by PKCt.e2: args2Role-mention-ngram: activation by thethe1: trigger-arg-path: phosphorylation >prep_of [lemma='raf'] >prep_by [lemma='pkc'] Gene_or_gene_productt.e2: args2Role-mention-ngram: ERK activation byt-e2: ents2Label-mention-ngram: involved in ERKt-e2: args2Role-mention-ngram: is also involvedt3interceding-token ngrams: kinase inhibitory proteintntrigger-to-trigger-path: e1:phosphorylate:Positive_regulation >dobj >vmod >prep_in >prep_of e2:complex:Bindingt,interceding-token ngrams: in dissociation oft\e1: trigger-arg-path: phosphorylate >nsubj [lemma='pkczeta'] controller:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkczeta'] Gene_or_gene_productt(interceding-token ngrams: protein ( RKIPt>e2: trigger-arg-path: complex:Binding >nn [lemma='rkip'] themetainterceding-tokens-full-span: kinase inhibitory protein ( RKIP ) resulting in dissociation of thetDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT can phosphorylatet6e2: trigger-arg-path: Binding >nn [lemma='rkip'] themet,interceding-token ngrams: inhibitory proteint?trigger-to-trigger-path: e1:phosphorylate:Positive_regulation >dobj [lemma='protein'] >vmod [lemma='result'] >prep_in [lemma='dissociation'] >prep_of [lemma='complex'] e2:complex:BindingtMe2: trigger-arg-path: complex:Binding >nn [lemma='rkip'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='rkip'] theme:Gene_or_gene_productt+interceding-token ngrams: kinase inhibitorytpe1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] controller:Gene_or_gene_productt[e1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] controllert6e1: ents2Label-mention-ngram: phosphorylate the SHAREDt3e1: ents2Label-mention-ngram: can phosphorylate thetme1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] controllertinterceding-token ngrams: RKIPtGe1: trigger-arg-path: phosphorylate >nsubj [lemma='pkczeta'] controllert*interceding-token ngrams: RKIP ) resultingt interceding-token ngrams: RKIP )tSe2: trigger-arg-path: complex:Binding >nn [lemma='raf1'] theme:Gene_or_gene_productt%interceding-token ngrams: ) resultingtMe2: trigger-arg-path: complex:Binding >nn [lemma='raf1'] Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='raf1'] theme:Gene_or_gene_productt?shortest-path: dobj [lemma='protein'] >vmod [lemma='result'] >prep_in [lemma='dissociation'] >prep_of [lemma='complex'] >nn [lemma='raf1']t6e2: trigger-arg-path: complex >nn [lemma='rkip'] themetQe1: trigger-arg-path: phosphorylate >nsubj [lemma='pkczeta'] Gene_or_gene_productt interceding-token ngrams: ( RKIPtPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='rkip'] themetWe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pkczeta'] Gene_or_gene_productt/e1: ents2Label-mention-ngram: phosphorylate thetee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='rkip'] theme:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] controller:Gene_or_gene_productt>e2: trigger-arg-path: complex:Binding >nn [lemma='raf1'] themet.interceding-token ngrams: inhibitory protein (tbe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pkczeta'] controller:Gene_or_gene_productt(interceding-token ngrams: ) resulting int_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='rkip'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='rkip'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='rkip'] Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='raf1'] Gene_or_gene_productt3interceding-token ngrams: resulting in dissociationtSe2: trigger-arg-path: complex:Binding >nn [lemma='rkip'] theme:Gene_or_gene_productt6e2: trigger-arg-path: complex >nn [lemma='raf1'] themetKe2: trigger-arg-path: complex >nn [lemma='rkip'] theme:Gene_or_gene_productt)interceding-token ngrams: in dissociationtne1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkczeta'] controller:Gene_or_gene_productt7shortest-path: dobj >vmod >prep_in >prep_of >nntMe1: trigger-arg-path: Positive_regulation >nsubj [lemma='pkczeta'] controllertHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='rkip'] themetEe2: trigger-arg-path: Binding >nn [lemma='rkip'] Gene_or_gene_producttee1: trigger-arg-path: phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='pkczeta'] controllert"interceding-token ngrams: ( RKIP )twe1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='pkczeta'] Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='rkip'] theme:Gene_or_gene_productt+e1: args2Role-mention-ngram: cycle arrest ,t)e1: args2Role-mention-ngram: cycle arresttMe1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_in controllert*e1: args2Role-mention-ngram: p53 dependentt1e1: ents2Label-mention-ngram: manner and involvest(shortest-path: dobj >nnt(e1: ents2Label-mention-ngram: by AMPK int3e1: args2Role-mention-ngram: CONTROLLER causes celltOe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_in Simple_chemicaltje1: trigger-arg-path: Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] Simple_chemicaltIe1: trigger-arg-path: Positive_regulation >nsubj >prep_in Simple_chemicalt+e1: args2Role-mention-ngram: is mediated byt.e1: args2Role-mention-ngram: cell cycle arrestt%e1: ents2Label-mention-ngram: AMPK int9e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL causes celltee1: trigger-arg-path: Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controllert'e1: args2Role-mention-ngram: by AMPK int,e1: args2Role-mention-ngram: a p53 dependentt$e1: args2Role-mention-ngram: AMPK int%e1: args2Role-mention-ngram: in a p53t&e1: ents2Label-mention-ngram: in a p53t.e1: args2Role-mention-ngram: causes cell cyclet*e1: ents2Label-mention-ngram: cycle arrestt-e2: ents2Label-mention-ngram: SHARED at Ser15tDe1: trigger-arg-path: Positive_regulation >nsubj >prep_in controllert&e1: args2Role-mention-ngram: AMPK in at.e1: args2Role-mention-ngram: CONTROLLER causest)e1: ents2Label-mention-ngram: causes cellt4e1: args2Role-mention-ngram: and involves CONTROLLEDtpe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='cell'] >prep_in [lemma='glucose'] Simple_chemicalt$e1: ents2Label-mention-ngram: arrestt{e1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controller:Simple_chemicalt0e1: args2Role-mention-ngram: manner and involvest>e1: trigger-arg-path: involves >nsubj >prep_in Simple_chemicalt=e1: ents2Label-mention-ngram: involves SHARED phosphorylationt,e1: ents2Label-mention-ngram: cycle arrest ,tZe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_in controller:Simple_chemicalt.e1: ents2Label-mention-ngram: mediated by AMPKt2e1: ents2Label-mention-ngram: dependent manner andt9e1: trigger-arg-path: involves >nsubj >prep_in controllert_e1: trigger-arg-path: involves >nsubj [lemma='cell'] >prep_in [lemma='glucose'] Simple_chemicalt+e1: args2Role-mention-ngram: arrest , whicht'e1: ents2Label-mention-ngram: AMPK in atRe1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_in Simple_chemicaltrshortest-path: dobj [lemma='phosphorylation'] >nn [lemma='ampk']t^e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_in controllertJe1: trigger-arg-path: lemmatizedTrigger=involve >nsubj >prep_in controllert.e1: args2Role-mention-ngram: which is mediatedt]e1: trigger-arg-path: involves:Positive_regulation >nsubj >prep_in controller:Simple_chemicalt%e1: ents2Label-mention-ngram: by AMPKt$e1: args2Role-mention-ngram: by AMPKtue1: trigger-arg-path: Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controller:Simple_chemicalt"e1: args2Role-mention-ngram: a p53t)e1: args2Role-mention-ngram: and involvestIe1: trigger-arg-path: involves >nsubj >prep_in controller:Simple_chemicalt%e1: args2Role-mention-ngram: arrest ,t2e1: ents2Label-mention-ngram: p53 dependent mannert#e1: args2Role-mention-ngram: arresttTe1: trigger-arg-path: Positive_regulation >nsubj >prep_in controller:Simple_chemicalt(e1: args2Role-mention-ngram: causes cellt~e1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controller:Simple_chemicalt-e1: ents2Label-mention-ngram: involves SHAREDt1e1: args2Role-mention-ngram: dependent manner andtke1: trigger-arg-path: lemmatizedTrigger=involve >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controllert(e1: args2Role-mention-ngram: is mediatedt/e1: ents2Label-mention-ngram: cell cycle arrestt-e1: ents2Label-mention-ngram: SHARED at Ser15t&e1: ents2Label-mention-ngram: arrest ,t-e1: ents2Label-mention-ngram: a p53 dependentt&e2: ents2Label-mention-ngram: at Ser15t/e1: ents2Label-mention-ngram: causes cell cycletje1: trigger-arg-path: involves >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controller:Simple_chemicalt1e1: ents2Label-mention-ngram: and involves SHAREDt-e1: args2Role-mention-ngram: mediated by AMPKt+e1: ents2Label-mention-ngram: p53 dependenttZe1: trigger-arg-path: involves >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controllert(e1: ents2Label-mention-ngram: manner andt#e1: ents2Label-mention-ngram: a p53tne1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_in controller:Simple_chemicaltse1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] Simple_chemicalt,e1: ents2Label-mention-ngram: arrest , whicht*e1: ents2Label-mention-ngram: and involvest4e1: ents2Label-mention-ngram: SIMPLE_CHEMICAL causeste1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controllert?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] Simple_chemicalt'e1: args2Role-mention-ngram: manner andtce1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj >prep_in Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=involve:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controller:Simple_chemicalt/e1: ents2Label-mention-ngram: which is mediatedt1e1: args2Role-mention-ngram: p53 dependent mannertne1: trigger-arg-path: involves:Positive_regulation >nsubj [lemma='cell'] >prep_in [lemma='glucose'] controllertMe1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='mek'] Gene_or_gene_producttRe1: trigger-arg-path: complex:Binding >nn [lemma='mek'] theme:Gene_or_gene_producttDe1: trigger-arg-path: complex >nn [lemma='mek'] Gene_or_gene_productt;e1: trigger-arg-path: complex nn [lemma='mek'] themet\e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mek'] theme:Gene_or_gene_producttPe1: trigger-arg-path: complex nn [lemma='mek'] Gene_or_gene_productt0shortest-path: prep_to >rcmod >nsubjtXe1: trigger-arg-path: complex:Binding nn [lemma='mek'] Gene_or_gene_productt=e1: trigger-arg-path: complex:Binding >nn [lemma='mek'] themet?trigger-to-trigger-path: e1:complex:Binding prep_to [lemma='membrane'] >rcmod [lemma='interact'] e2:interact:Bindingt\e1: trigger-arg-path: lemmatizedTrigger=complex nn [lemma='mek'] theme:Gene_or_gene_productt5e1: trigger-arg-path: Binding >nn [lemma='mek'] themetCe1: trigger-arg-path: complex:Binding nn [lemma='mek'] theme:Gene_or_gene_producttushortest-path: prep_to [lemma='membrane'] >rcmod [lemma='interact'] >nsubj [lemma='it']tGe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mek'] themetJe1: trigger-arg-path: Binding >nn [lemma='mek'] theme:Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=complex prep_to >rcmod e2:interact:Bindingt5e1: trigger-arg-path: complex >nn [lemma='mek'] themetje1: trigger-arg-path: lemmatizedTrigger=complex:Binding nn [lemma='mek'] Gene_or_gene_productt^e2: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicalt[e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicalt?shortest-path: ccomp [lemma='induce'] >nsubj [lemma='peroxide'] >nn [lemma='hydrogen']tXe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] Simple_chemicaltGe2: trigger-arg-path: induced >nsubj [lemma='peroxide'] Simple_chemicaltge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] controllertce2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] controller:Simple_chemicaltRe2: trigger-arg-path: induced >nsubj [lemma='peroxide'] controller:Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='peroxide'] controllertVe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] controllertwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltSe2: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='peroxide'] Simple_chemicaltNe2: trigger-arg-path: Positive_regulation >nsubj [lemma='peroxide'] controllert0shortest-path: ccomp >nsubj >nntfe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='peroxide'] controller:Simple_chemicaltBe2: trigger-arg-path: induced >nsubj [lemma='peroxide'] controllert1e1: args2Role-mention-ngram: and ( p27-luciferaset.e1: ents2Label-mention-ngram: on two differentt$e1: ents2Label-mention-ngram: notiont.e2: trigger-arg-path: induce >nsubj controllert)e1: ents2Label-mention-ngram: transfectedtCe2: trigger-arg-path: induce >nsubj controller:Gene_or_gene_productt"e1: args2Role-mention-ngram: ) ) ,t-e1: ents2Label-mention-ngram: the notion thattde2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mdm2'] controller:Gene_or_gene_producttWe2: trigger-arg-path: induce:Positive_regulation >nsubj controller:Gene_or_gene_productt1e1: args2Role-mention-ngram: ( 6xDBE-luciferase )t2e1: ents2Label-mention-ngram: ( ( 6xDBE-luciferaset#e1: ents2Label-mention-ngram: ) ) ,t(e1: args2Role-mention-ngram: notion thatt"e1: args2Role-mention-ngram: FOXO4t3e1: args2Role-mention-ngram: 6xDBE-luciferase ) andt8e1: ents2Label-mention-ngram: induce mono-ubiquitinationt6e1: args2Role-mention-ngram: different FOXO responsivet,e1: ents2Label-mention-ngram: p27-luciferaset)e1: args2Role-mention-ngram: , consistentt/e1: args2Role-mention-ngram: two different FOXOt3e1: args2Role-mention-ngram: induced a reproduciblet+e1: args2Role-mention-ngram: ) , consistentt/e1: args2Role-mention-ngram: ( p27-luciferase )t0e1: ents2Label-mention-ngram: notion that SHAREDt1e1: ents2Label-mention-ngram: consistent with thet(e1: args2Role-mention-ngram: reporters (t0e1: ents2Label-mention-ngram: ( p27-luciferase )t4e1: ents2Label-mention-ngram: 6xDBE-luciferase ) andt!e1: ents2Label-mention-ngram: ) )t4e1: ents2Label-mention-ngram: induced a reproduciblet-e1: ents2Label-mention-ngram: FOXO responsivet1e1: args2Role-mention-ngram: ( ( 6xDBE-luciferaset)e1: ents2Label-mention-ngram: activity ont'e1: ents2Label-mention-ngram: induced at&e1: args2Role-mention-ngram: reporterstYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mdm2'] Gene_or_gene_productt-e1: args2Role-mention-ngram: p27-luciferase )t/e1: ents2Label-mention-ngram: increase in FOXO4tnsubj Gene_or_gene_productt,e1: ents2Label-mention-ngram: different FOXOt~e1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt\trigger-to-trigger-path: e1:induced:Positive_regulation >ccomp e2:induce:Positive_regulationt,e1: args2Role-mention-ngram: consistent witht2e1: args2Role-mention-ngram: reproducible increasetie1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controllert#e1: args2Role-mention-ngram: notiont-e1: args2Role-mention-ngram: on two differenttXe1: trigger-arg-path: induced >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controllert2e2: args2Role-mention-ngram: can induce CONTROLLEDt}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controllert/e1: args2Role-mention-ngram: 6xDBE-luciferase )t&e1: args2Role-mention-ngram: differenttce2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mdm2'] controllert3e1: ents2Label-mention-ngram: transfected induced at2e1: ents2Label-mention-ngram: responsive reporterst-e1: ents2Label-mention-ngram: that SHARED cant/e1: ents2Label-mention-ngram: SHARED can inducet3e1: ents2Label-mention-ngram: reproducible increaset*e1: args2Role-mention-ngram: reporters ( (t(e1: args2Role-mention-ngram: transfectedt+e1: args2Role-mention-ngram: a reproducibletmtrigger-to-trigger-path: e1:induced:Positive_regulation >ccomp [lemma='induce'] e2:induce:Positive_regulationt'e2: args2Role-mention-ngram: can inducet*e1: ents2Label-mention-ngram: , consistentt1e1: ents2Label-mention-ngram: transfected inducedt4e1: args2Role-mention-ngram: a reproducible increasetxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt0e1: ents2Label-mention-ngram: two different FOXOt e1: args2Role-mention-ngram: ( (t'e1: ents2Label-mention-ngram: reporterst6e1: ents2Label-mention-ngram: reproducible increase int"e1: args2Role-mention-ngram: and (t.e1: ents2Label-mention-ngram: ( p27-luciferaset(e1: ents2Label-mention-ngram: consistentt2e1: args2Role-mention-ngram: transfected induced at*e1: args2Role-mention-ngram: two differentt=e2: trigger-arg-path: induce >nsubj [lemma='mdm2'] controllertQe2: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='mdm2'] controllert(e1: ents2Label-mention-ngram: responsivet'e1: args2Role-mention-ngram: the notiont!e1: args2Role-mention-ngram: FOXOt;e1: args2Role-mention-ngram: CONTROLLER transfected inducedt3e1: args2Role-mention-ngram: responsive reporters (t(e2: ents2Label-mention-ngram: can inducet(e1: ents2Label-mention-ngram: the notiont(e1: args2Role-mention-ngram: activity ontme1: trigger-arg-path: induced >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: reproduciblet5e1: args2Role-mention-ngram: reproducible increase int0e1: args2Role-mention-ngram: consistent with thet3e1: ents2Label-mention-ngram: FOXO4 transcriptionaltOe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='mdm2'] controllert0e1: ents2Label-mention-ngram: 6xDBE-luciferase )t.e1: ents2Label-mention-ngram: 6xDBE-luciferaset%e1: args2Role-mention-ngram: in FOXO4t/e1: args2Role-mention-ngram: ( 6xDBE-luciferaset;e2: ents2Label-mention-ngram: induce mono-ubiquitination oftRe2: trigger-arg-path: induce >nsubj [lemma='mdm2'] controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: FOXO responsive reporterst;e1: ents2Label-mention-ngram: induce mono-ubiquitination oft8e2: ents2Label-mention-ngram: induce mono-ubiquitinationt4e1: ents2Label-mention-ngram: responsive reporters (t'e1: args2Role-mention-ngram: responsivet?e1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt;e1: args2Role-mention-ngram: FOXO4 transcriptional activitytve1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: ) , consistentt'e1: args2Role-mention-ngram: consistentt,e1: args2Role-mention-ngram: activity on twot&e1: ents2Label-mention-ngram: in FOXO4t.e1: args2Role-mention-ngram: , consistent withtbe1: trigger-arg-path: induced >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] Gene_or_gene_productt+e1: args2Role-mention-ngram: p27-luciferaset-e1: ents2Label-mention-ngram: consistent witht8e2: trigger-arg-path: induce >nsubj Gene_or_gene_productt2e1: args2Role-mention-ngram: FOXO4 transcriptionalt#e1: ents2Label-mention-ngram: and (tme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] Gene_or_gene_productt9e1: ents2Label-mention-ngram: transcriptional activity ont,e1: args2Role-mention-ngram: with the notiont e1: args2Role-mention-ngram: ) )t'e1: ents2Label-mention-ngram: differentt-e1: args2Role-mention-ngram: ( p27-luciferaset$e1: ents2Label-mention-ngram: on twot,e1: ents2Label-mention-ngram: a reproduciblet0e1: args2Role-mention-ngram: transfected inducedt7e1: ents2Label-mention-ngram: different FOXO responsivetBe2: trigger-arg-path: induce:Positive_regulation >nsubj controllert0e1: ents2Label-mention-ngram: ( 6xDBE-luciferaset1e1: args2Role-mention-ngram: responsive reporterst(e1: ents2Label-mention-ngram: can inducet,e1: args2Role-mention-ngram: the notion thatt6e1: ents2Label-mention-ngram: in FOXO4 transcriptionalt-e1: args2Role-mention-ngram: 6xDBE-luciferaset/e2: ents2Label-mention-ngram: SHARED can inducet3e1: args2Role-mention-ngram: CONTROLLER transfectedt"e1: ents2Label-mention-ngram: FOXOt3e1: args2Role-mention-ngram: notion that CONTROLLEDt)e1: ents2Label-mention-ngram: notion thatt.e1: args2Role-mention-ngram: increase in FOXO4tde1: trigger-arg-path: Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controllert-e1: ents2Label-mention-ngram: activity on twot2e2: args2Role-mention-ngram: CONTROLLER can inducetye1: trigger-arg-path: Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt[e2: trigger-arg-path: induce:Positive_regulation >nsubj [lemma='mdm2'] Gene_or_gene_productt8e1: args2Role-mention-ngram: transcriptional activity ont2e1: ents2Label-mention-ngram: ( 6xDBE-luciferase )tnsubj [lemma='amount'] >prep_of [lemma='mdm2'] Gene_or_gene_productt+e1: args2Role-mention-ngram: different FOXOt/e1: args2Role-mention-ngram: p27-luciferase ) )t0e1: ents2Label-mention-ngram: SHARED transfectedt*e1: ents2Label-mention-ngram: reproduciblet6e1: args2Role-mention-ngram: FOXO responsive reporterst%e1: ents2Label-mention-ngram: ) and (t$e1: args2Role-mention-ngram: ) and (t-e1: ents2Label-mention-ngram: with the notiont&e1: args2Role-mention-ngram: induced at#e1: args2Role-mention-ngram: on twot,e1: args2Role-mention-ngram: FOXO responsivetGe2: trigger-arg-path: induce >nsubj [lemma='mdm2'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: reporters (tnshortest-path: ccomp [lemma='induce'] >nsubj [lemma='mdm2']t0e1: ents2Label-mention-ngram: p27-luciferase ) )t+e1: ents2Label-mention-ngram: two differentt e1: args2Role-mention-ngram: twotnsubj [lemma='mdm2'] controller:Gene_or_gene_productt.e1: ents2Label-mention-ngram: p27-luciferase )t?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: , consistent witht!e1: ents2Label-mention-ngram: ( (tle1: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='amount'] >prep_of [lemma='mdm2'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] controllert/e2: ents2Label-mention-ngram: of SHARED inducedtre2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlledt^e2: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlledtPe2: trigger-arg-path: lemmatizedTrigger=induce >agent controller:Simple_chemicaltltrigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj >prep_of >vmod e2:induced:Positive_regulationtae2: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlledtbe2: trigger-arg-path: Positive_regulation nsubj >prep_of Negative_regulationt@e2: trigger-arg-path: Positive_regulation >agent Simple_chemicaltMe2: trigger-arg-path: induced nsubj >prep_of controlledtSe2: trigger-arg-path: induced:Positive_regulation >agent controller:Simple_chemicaltSe2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] controllertYe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent Simple_chemicalt[e2: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] Simple_chemicalt^e2: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicaltge2: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of Negative_regulationt?trigger-to-trigger-path: e1:inhibits:Negative_regulation >dobj [lemma='mono-ubiquitination'] >prep_of [lemma='foxo'] >vmod [lemma='induce'] e2:induced:Positive_regulationtme2: trigger-arg-path: Positive_regulation nsubj >prep_of controlled:Negative_regulationt/e2: ents2Label-mention-ngram: SHARED induced byt=e2: ents2Label-mention-ngram: inhibits mono-ubiquitination oft?e2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationtYe2: trigger-arg-path: Positive_regulation nsubj >prep_of controlledtHe2: trigger-arg-path: induced:Positive_regulation >agent Simple_chemicaltGe2: trigger-arg-path: induced >agent [lemma='peroxide'] Simple_chemicaltVe2: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] controllert/e2: ents2Label-mention-ngram: induced by SHAREDt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of Negative_regulationt?e2: trigger-arg-path: induced >agent controller:Simple_chemicaltDshortest-path: agent controller:Simple_chemicaltVe2: trigger-arg-path: induced nsubj >prep_of Negative_regulationtXe2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] Simple_chemicaltRe2: trigger-arg-path: induced >agent [lemma='peroxide'] controller:Simple_chemicaltNe2: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj >prep_of controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationt4e2: trigger-arg-path: induced >agent Simple_chemicaltje2: trigger-arg-path: induced:Positive_regulation nsubj >prep_of Negative_regulationtBe2: trigger-arg-path: induced >agent [lemma='peroxide'] controllertce2: trigger-arg-path: lemmatizedTrigger=induce >agent [lemma='peroxide'] controller:Simple_chemicalt?e2: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] Simple_chemicaltEe2: trigger-arg-path: lemmatizedTrigger=induce >agent Simple_chemicalt?e2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtSe2: trigger-arg-path: Positive_regulation >agent [lemma='peroxide'] Simple_chemicaltwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicalt?e2: trigger-arg-path: induced:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationt?e2: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationtae2: trigger-arg-path: induced nsubj >prep_of controlled:Negative_regulationt?e2: trigger-arg-path: induced nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtue2: trigger-arg-path: induced:Positive_regulation nsubj >prep_of controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtre2: trigger-arg-path: lemmatizedTrigger=induce nsubj >prep_of controlled:Negative_regulationt?e2: trigger-arg-path: Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlledtAe2: ents2Label-mention-ngram: SHARED inhibits mono-ubiquitinationt:e2: ents2Label-mention-ngram: inhibits mono-ubiquitinationtde2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >agent controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] controlled:Negative_regulationt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation nsubj [lemma='depletion'] >prep_of [lemma='mdm2'] Negative_regulationtfe2: trigger-arg-path: induced:Positive_regulation >agent [lemma='peroxide'] controller:Simple_chemicalt0e2: ents2Label-mention-ngram: c-myb by targetingt(interceding-token ngrams: proteins , fort'e2: args2Role-mention-ngram: genes liket1e2: args2Role-mention-ngram: represses expressiont&e2: args2Role-mention-ngram: targetingt?e2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlled:Gene_or_gene_productt6e1: ents2Label-mention-ngram: interactions with SHAREDtPe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='tax1'] controllert_e2: trigger-arg-path: Negative_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='protein'] >nn [lemma='creb'] themet%e2: args2Role-mention-ngram: c-myb bytje2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj controller:Gene_or_gene_productt\e2: trigger-arg-path: represses:Negative_activation >prepc_by >dobj >nn Gene_or_gene_producttFe2: trigger-arg-path: represses >nsubj controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: represses expressiont%interceding-token ngrams: interleukintRe2: trigger-arg-path: represses:Negative_activation >prepc_by >dobj >nn controlledt*e2: args2Role-mention-ngram: of genes liket1e2: ents2Label-mention-ngram: by targeting SHAREDtle2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by >dobj >nn Gene_or_gene_producttinterceding-token ngrams: ATFt*e2: ents2Label-mention-ngram: and c-myb bytoe2: trigger-arg-path: represses >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlledt/e2: args2Role-mention-ngram: c-myb by targetingt$e2: args2Role-mention-ngram: A , p53tqe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] themet0e2: args2Role-mention-ngram: expression of genest*interceding-token ngrams: and ATF proteinstZe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='tax1'] Gene_or_gene_productt.e2: ents2Label-mention-ngram: targeting SHAREDtce2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by >dobj >nn controlled:Gene_or_gene_productt/e2: ents2Label-mention-ngram: genes like cyclintDe1: trigger-arg-path: interactions:Binding >poss [lemma='its'] themetge2: trigger-arg-path: represses:Negative_activation >prepc_by >dobj >nn controlled:Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by >dobj >nn controlled:Gene_or_gene_producttZe2: trigger-arg-path: represses:Negative_activation >nsubj controller:Gene_or_gene_productt(e2: ents2Label-mention-ngram: genes liket^e2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='tax1'] Gene_or_gene_productt"e2: args2Role-mention-ngram: genestLe1: trigger-arg-path: interactions >prep_with >nn theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: like cyclin AtNe2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by >dobj >nn controlledtWe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with >nn Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED also repressest&e2: ents2Label-mention-ngram: cyclin At(interceding-token ngrams: ATF proteins ,tSe2: trigger-arg-path: represses >prepc_by >dobj >nn controlled:Gene_or_gene_productt'interceding-token ngrams: , for examplet#e2: ents2Label-mention-ngram: c-mybt1e1: ents2Label-mention-ngram: SHARED interactionstye2: trigger-arg-path: represses >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] Gene_or_gene_producttXe1: trigger-arg-path: interactions >prep_with [lemma='protein'] >nn [lemma='creb'] themet%e2: args2Role-mention-ngram: of genest?e2: trigger-arg-path: represses:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] Gene_or_gene_producttTe1: trigger-arg-path: interactions:Binding >prep_with >nn theme:Gene_or_gene_productt#e2: ents2Label-mention-ngram: genest1e2: args2Role-mention-ngram: targeting CONTROLLEDt?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: c-myb byt!interceding-token ngrams: c-fos .t(interceding-token ngrams: interleukin 17t"e2: args2Role-mention-ngram: c-mybt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] Gene_or_gene_productt&interceding-token ngrams: ATF proteinst.e1: args2Role-mention-ngram: interactions witht'interceding-token ngrams: example thosetKe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj Gene_or_gene_productt%interceding-token ngrams: 17 or c-fost~e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='protein'] >nn [lemma='creb'] theme:Gene_or_gene_productt,interceding-token ngrams: c-fos . ConverselytAe1: trigger-arg-path: Binding >prep_with >nn Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=repress >nsubj controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: of genes liket.interceding-token ngrams: encoding interleukintHe2: trigger-arg-path: Negative_activation >prepc_by >dobj >nn controlledt?e2: trigger-arg-path: represses >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: represses >nsubj [lemma='tax1'] controller:Gene_or_gene_productt6e1: ents2Label-mention-ngram: SHARED interactions witht4e2: args2Role-mention-ngram: represses expression oft+e2: args2Role-mention-ngram: also repressest!interceding-token ngrams: and ATFtoe1: trigger-arg-path: interactions:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] Gene_or_gene_productt"interceding-token ngrams: encodingtbe2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by >dobj >nn controlledtde2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='tax1'] controllert*e2: args2Role-mention-ngram: p53 and c-mybt]e1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with >nn theme:Gene_or_gene_producttTe2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='tax1'] controllert*e2: ents2Label-mention-ngram: by targetingtrinterceding-tokens-full-span: and ATF proteins , for example those encoding interleukin 17 or c-fos . Conversely ,t!e2: ents2Label-mention-ngram: A ,t,e2: ents2Label-mention-ngram: also repressest$interceding-token ngrams: or c-fos .t)e2: args2Role-mention-ngram: and c-myb byt+e2: ents2Label-mention-ngram: like cyclin At&e2: ents2Label-mention-ngram: of genestRe2: trigger-arg-path: Negative_activation >prepc_by >dobj >nn Gene_or_gene_producttJe2: trigger-arg-path: represses >nsubj [lemma='tax1'] Gene_or_gene_productt;e2: trigger-arg-path: represses >nsubj Gene_or_gene_productt(e2: ents2Label-mention-ngram: cyclin A ,tye2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlledt4e2: args2Role-mention-ngram: by targeting CONTROLLEDt@e2: trigger-arg-path: represses >nsubj [lemma='tax1'] controllertSe1: trigger-arg-path: Binding >prep_with [lemma='protein'] >nn [lemma='creb'] themet?e2: trigger-arg-path: represses:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlledt'e2: args2Role-mention-ngram: cyclin A ,t?e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlled:Gene_or_gene_productt2e1: trigger-arg-path: Binding >prep_with >nn themetge1: trigger-arg-path: interactions >prep_with [lemma='protein'] >nn [lemma='creb'] Gene_or_gene_productt6e2: args2Role-mention-ngram: also represses expressiontJe2: trigger-arg-path: Negative_activation >nsubj [lemma='tax1'] controllertposs [lemma='its'] themet1interceding-token ngrams: encoding interleukin 17t4e1: args2Role-mention-ngram: THEME interactions witht?e2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] Gene_or_gene_producttFe1: trigger-arg-path: interactions >prep_with >nn Gene_or_gene_productt]e2: trigger-arg-path: Negative_activation >prepc_by >dobj >nn controlled:Gene_or_gene_productt'e2: ents2Label-mention-ngram: and c-mybtxe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with [lemma='protein'] >nn [lemma='creb'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: p53 and c-mybtGe1: trigger-arg-path: Binding >prep_with >nn theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_with >nn themetme1: trigger-arg-path: interactions >prep_with [lemma='protein'] >nn [lemma='creb'] theme:Gene_or_gene_productt4interceding-token ngrams: those encoding interleukint)e2: args2Role-mention-ngram: by targetingt+interceding-token ngrams: interleukin 17 ort7e2: ents2Label-mention-ngram: also represses expressiontinterceding-token ngrams: 17tKe1: trigger-arg-path: interactions >poss [lemma='its'] theme:Generic_entitytNe1: trigger-arg-path: interactions:Binding >prep_with >nn Gene_or_gene_productt)e2: ents2Label-mention-ngram: like cyclint>e2: trigger-arg-path: represses >prepc_by >dobj >nn controlledtXe2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by >dobj >nn Gene_or_gene_producttie2: trigger-arg-path: represses:Negative_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_productt?e2: trigger-arg-path: Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] Gene_or_gene_producttEe1: trigger-arg-path: interactions >poss [lemma='its'] Generic_entitytee2: trigger-arg-path: lemmatizedTrigger=repress >nsubj [lemma='tax1'] controller:Gene_or_gene_producttHe2: trigger-arg-path: represses >prepc_by >dobj >nn Gene_or_gene_productthe1: trigger-arg-path: Binding >prep_with [lemma='protein'] >nn [lemma='creb'] theme:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with >nn Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with >nn theme:Gene_or_gene_productt e2: args2Role-mention-ngram: A ,t.e2: args2Role-mention-ngram: genes like cyclintinterceding-token ngrams: thoset&e2: args2Role-mention-ngram: and c-mybtue1: trigger-arg-path: interactions:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] theme:Gene_or_gene_productt`e1: trigger-arg-path: interactions:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] themet?e2: trigger-arg-path: Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlled:Gene_or_gene_producttMe1: trigger-arg-path: interactions:Binding >poss [lemma='its'] Generic_entityt/e1: ents2Label-mention-ngram: interactions witht1e2: ents2Label-mention-ngram: expression of genest?e1: trigger-arg-path: interactions:Binding >prep_with >nn themet0interceding-token ngrams: example those encodingt(interceding-token ngrams: those encodingt'e2: ents2Label-mention-ngram: , p53 andt$CSSPATH: ROOT >prep_through ++ ROOT tOe2: trigger-arg-path: represses:Negative_activation >nsubj Gene_or_gene_producttinterceding-token ngrams: 17 ortSe1: trigger-arg-path: interactions:Binding >poss [lemma='its'] theme:Generic_entityt%interceding-token ngrams: for examplet?e2: trigger-arg-path: represses:Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlled:Gene_or_gene_productt5e2: ents2Label-mention-ngram: represses expression oft+interceding-token ngrams: for example thoset"e2: args2Role-mention-ngram: , p53tbe1: trigger-arg-path: Binding >prep_with [lemma='protein'] >nn [lemma='creb'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with [lemma='protein'] >nn [lemma='creb'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: targetingt(e2: args2Role-mention-ngram: like cyclintPe1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_with >nn themetTe2: trigger-arg-path: Negative_activation >nsubj [lemma='tax1'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=repress >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlledt4e1: args2Role-mention-ngram: interactions with THEMEt%e2: ents2Label-mention-ngram: A , p53tinterceding-token ngrams: c-fost7e1: trigger-arg-path: interactions >prep_with >nn themetye2: trigger-arg-path: Negative_activation >prepc_by [lemma='target'] >dobj [lemma='factor'] >nn [lemma='creb'] controlledt"interceding-token ngrams: or c-fostne2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj [lemma='tax1'] Gene_or_gene_productt%e2: args2Role-mention-ngram: cyclin At6e2: args2Role-mention-ngram: CONTROLLER also repressest&e2: args2Role-mention-ngram: , p53 andt_e2: trigger-arg-path: lemmatizedTrigger=repress:Negative_activation >nsubj Gene_or_gene_productt)e1: args2Role-mention-ngram: a variety oft(e1: args2Role-mention-ngram: through itst&e1: ents2Label-mention-ngram: CREB andtZe1: trigger-arg-path: activates:Positive_activation >nsubj controller:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='those'] controlledt?e1: trigger-arg-path: activates >dobj controlled:Generic_entityt/e1: ents2Label-mention-ngram: of cellular genest/e1: args2Role-mention-ngram: example CONTROLLEDt.e1: args2Role-mention-ngram: genes through itst&e1: args2Role-mention-ngram: a varietytIe1: trigger-arg-path: Positive_activation >dobj controlled:Generic_entitytQe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax1'] controllertJe1: trigger-arg-path: activates >nsubj [lemma='tax1'] Gene_or_gene_productt2e1: args2Role-mention-ngram: its interactions withtce1: trigger-arg-path: activates:Positive_activation >dobj [lemma='those'] controlled:Generic_entityt1e1: ents2Label-mention-ngram: variety of cellulart(e1: args2Role-mention-ngram: activates at!e1: args2Role-mention-ngram: CREBtde1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj controlled:Generic_entityt^e1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='tax1'] Gene_or_gene_productt,e1: ents2Label-mention-ngram: proteins , fort+e1: ents2Label-mention-ngram: with CREB andt[e1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax1'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: for examplet0e1: args2Role-mention-ngram: activates a varietytTe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='those'] controlledt3e1: ents2Label-mention-ngram: its interactions witht+e1: ents2Label-mention-ngram: , for exampletHe1: trigger-arg-path: activates:Positive_activation >dobj Generic_entityt(e1: ents2Label-mention-ngram: variety oftNe1: trigger-arg-path: Positive_activation >dobj [lemma='those'] Generic_entitytTe1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='tax1'] controllertOe1: trigger-arg-path: activates >dobj [lemma='those'] controlled:Generic_entitytXe1: trigger-arg-path: activates:Positive_activation >dobj [lemma='those'] Generic_entityt*e1: ents2Label-mention-ngram: ATF proteinst,e1: ents2Label-mention-ngram: ATF proteins ,t.e1: ents2Label-mention-ngram: its interactionst!e1: ents2Label-mention-ngram: ATFt)e1: args2Role-mention-ngram: CREB and ATFt*e1: args2Role-mention-ngram: genes throught'e1: args2Role-mention-ngram: variety oftYe1: trigger-arg-path: Positive_activation >dobj [lemma='those'] controlled:Generic_entityt,e1: ents2Label-mention-ngram: cellular genest'e1: ents2Label-mention-ngram: a varietyt,e1: ents2Label-mention-ngram: example SHAREDt_e1: trigger-arg-path: Positive_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_producttFe1: trigger-arg-path: activates >nsubj controller:Gene_or_gene_productt(e1: args2Role-mention-ngram: for examplet%e1: ents2Label-mention-ngram: examplet@e1: trigger-arg-path: activates >dobj [lemma='those'] controlledt)e1: ents2Label-mention-ngram: of cellulart$e1: args2Role-mention-ngram: examplet.e1: ents2Label-mention-ngram: and ATF proteinst&e1: args2Role-mention-ngram: with CREBt0e1: args2Role-mention-ngram: variety of cellulart*e1: ents2Label-mention-ngram: a variety oft@e1: trigger-arg-path: activates >nsubj [lemma='tax1'] controllert/e1: ents2Label-mention-ngram: genes through itstOe1: trigger-arg-path: activates:Positive_activation >nsubj Gene_or_gene_productt4e1: trigger-arg-path: activates >dobj Generic_entityt=e1-label: Positive_activation + e2-label: Negative_activationt0e1: ents2Label-mention-ngram: for example SHAREDtie1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='those'] Generic_entitytUe1: trigger-arg-path: activates >nsubj [lemma='tax1'] controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='those'] controlledt>e1: trigger-arg-path: Positive_activation >dobj Generic_entityt3e1: args2Role-mention-ngram: for example CONTROLLEDt-e1: args2Role-mention-ngram: its interactionst*e1: args2Role-mention-ngram: , for exampletie1: trigger-arg-path: activates:Positive_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_producttoe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax1'] Gene_or_gene_productt.e1: args2Role-mention-ngram: of cellular genestze1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax1'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: CONTROLLER activates atfe1: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='tax1'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: with CREB andt`e1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='those'] controlled:Generic_entitytee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='tax1'] controllertJe1: trigger-arg-path: Positive_activation >dobj [lemma='those'] controlledtJe1: trigger-arg-path: Positive_activation >nsubj [lemma='tax1'] controllert6e1: ents2Label-mention-ngram: through its interactionst(e1: args2Role-mention-ngram: of cellulart#e1: ents2Label-mention-ngram: , fort"e1: args2Role-mention-ngram: , fort-e1: args2Role-mention-ngram: and ATF proteinst"e1: ents2Label-mention-ngram: CREBt3e1: args2Role-mention-ngram: interactions with CREBtDe1: trigger-arg-path: activates >dobj [lemma='those'] Generic_entitytUe1: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='those'] Generic_entityt$e1: args2Role-mention-ngram: and ATFt0e1: ents2Label-mention-ngram: SHARED activates at)e1: ents2Label-mention-ngram: through itst$e1: args2Role-mention-ngram: varietyt'e1: ents2Label-mention-ngram: with CREBtte1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='those'] controlled:Generic_entityt%e1: ents2Label-mention-ngram: varietyt4e1: ents2Label-mention-ngram: interactions with CREBt%e1: ents2Label-mention-ngram: and ATFt3e1: args2Role-mention-ngram: cellular genes throught;e1: trigger-arg-path: activates >nsubj Gene_or_gene_producttTe1: trigger-arg-path: Positive_activation >nsubj [lemma='tax1'] Gene_or_gene_productt+e1: args2Role-mention-ngram: cellular genest*e1: ents2Label-mention-ngram: CREB and ATFt5e1: args2Role-mention-ngram: through its interactionstEe1: trigger-arg-path: lemmatizedTrigger=activate >dobj Generic_entityt+e1: args2Role-mention-ngram: proteins , fort4e1: ents2Label-mention-ngram: cellular genes throught1e1: ents2Label-mention-ngram: activates a varietyt e1: args2Role-mention-ngram: ATFt)e1: ents2Label-mention-ngram: activates at)e1: args2Role-mention-ngram: ATF proteinstSe1: trigger-arg-path: activates:Positive_activation >dobj controlled:Generic_entitytYe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj Generic_entitytMinterceding-tokens-full-span: encoding interleukin 17 or c-fos . Conversely ,t"e1: args2Role-mention-ngram: genest%e1: args2Role-mention-ngram: CREB andt+e1: ents2Label-mention-ngram: genes throught+e1: args2Role-mention-ngram: ATF proteins ,tPe1: trigger-arg-path: lemmatizedTrigger=activate >dobj controlled:Generic_entityt#e1: ents2Label-mention-ngram: genest$e2: ents2Label-mention-ngram: familyt@e2: ents2Label-mention-ngram: inhibited the auto-phosphorylationt1e2: ents2Label-mention-ngram: Src family tyrosinet:e2: ents2Label-mention-ngram: the auto-phosphorylation andtqinterceding-tokens-full-span: , although it will not bind mutationally activated v-Src . In addition , binding oft&interceding-token ngrams: , binding oftinterceding-token ngrams: willt#interceding-token ngrams: , bindingt?e2: ents2Label-mention-ngram: or GENE_OR_GENE_PRODUCT inhibitedtJe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT or GENE_OR_GENE_PRODUCTt6interceding-token ngrams: mutationally activated v-Srct"interceding-token ngrams: not bindt@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibited thet&interceding-token ngrams: mutationallyt6e2: ents2Label-mention-ngram: auto-phosphorylation andt,e2: ents2Label-mention-ngram: SHARED and thet)interceding-token ngrams: activated v-Srct!interceding-token ngrams: v-Src .t5interceding-token ngrams: bind mutationally activatedt/interceding-token ngrams: not bind mutationallyt,interceding-token ngrams: addition , bindingt"interceding-token ngrams: will nott'interceding-token ngrams: will not bindt)e2: ents2Label-mention-ngram: related Srct5e2: args2Role-mention-ngram: CONTROLLER inhibited thet%interceding-token ngrams: it will nottinterceding-token ngrams: v-Srct$interceding-token ngrams: v-Src . IntAe2: ents2Label-mention-ngram: auto-phosphorylation and activationt+interceding-token ngrams: activated v-Src .t0interceding-token ngrams: mutationally activatedt0e2: ents2Label-mention-ngram: related Src familyt'interceding-token ngrams: , although itt-e2: ents2Label-mention-ngram: and the relatedt-e2: ents2Label-mention-ngram: the related Srct-e2: ents2Label-mention-ngram: family tyrosinet2e2: ents2Label-mention-ngram: auto-phosphorylationtccomp ++ ROOT >nsubj >rcmodtHe2: trigger-arg-path: co-immunoprecipitated nsubj [lemma='it'] themetae1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='cd55'] Gene_or_gene_producttRe1: trigger-arg-path: Binding >prep_with [lemma='cd55'] theme:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='cd55'] Gene_or_gene_producttee2: trigger-arg-path: co-immunoprecipitated:Binding prep_with [lemma='cd55'] Gene_or_gene_productt"interceding-token ngrams: and onlytfe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding nsubj Generic_entityt#interceding-token ngrams: marker oftLe1: trigger-arg-path: Binding >prep_with [lemma='cd55'] Gene_or_gene_producttZe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='cd55'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate >prep_with [lemma='cd55'] Gene_or_gene_producttFe1: trigger-arg-path: coimmunoprecipitated >nsubj theme:Generic_entityt=e1: trigger-arg-path: Binding >prep_with [lemma='cd55'] themetWe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubj theme:Generic_entitytNe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubj theme:Generic_entitytje1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='cd55'] Gene_or_gene_producttUe2: trigger-arg-path: co-immunoprecipitated:Binding prep_with [lemma='cd55'] theme:Gene_or_gene_producttre1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >prep_with [lemma='cd55'] Gene_or_gene_producttnsubj themet)e2: ents2Label-mention-ngram: SHARED thattMe2: trigger-arg-path: co-immunoprecipitated prep_with [lemma='cd55'] themet#interceding-token ngrams: Followingt*interceding-token ngrams: caveolar rafts ,t_e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubj theme:Generic_entitytye2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='cd55'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubj [lemma='it'] theme:Generic_entityt=e2: trigger-arg-path: Binding >prep_with [lemma='cd55'] themet=e2: args2Role-mention-ngram: THEME that co-immunoprecipitatedt$interceding-token ngrams: PDGF , thet>e1: ents2Label-mention-ngram: SHARED coimmunoprecipitated withtUe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubj [lemma='it'] Generic_entityt/interceding-token ngrams: co-immunoprecipitatedt%interceding-token ngrams: . Followingt`e2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding prep_with [lemma='cd55'] theme:Gene_or_gene_producttKe2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='cd55'] themet$interceding-token ngrams: , a markert]e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubj [lemma='it'] themet/interceding-token ngrams: . Following treatmentt8e2: ents2Label-mention-ngram: that co-immunoprecipitatedt7e1: trigger-arg-path: coimmunoprecipitated >nsubj themet`e2: trigger-arg-path: co-immunoprecipitated >prep_with [lemma='cd55'] theme:Gene_or_gene_producttYe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate prep_with [lemma='cd55'] Gene_or_gene_productt@e2: trigger-arg-path: co-immunoprecipitated:Binding nsubj Generic_entitytle1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate:Binding >nsubj [lemma='it'] theme:Generic_entityt%interceding-token ngrams: a marker oft(interceding-token ngrams: caveolar raftstLe1: trigger-arg-path: coimmunoprecipitated:Binding >nsubj [lemma='it'] themet interceding-token ngrams: PDGF ,t8e2: trigger-arg-path: co-immunoprecipitated nsubj [lemma='it'] Generic_entitytinterceding-token ngrams: nont"interceding-token ngrams: a markertve2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding prep_with [lemma='cd55'] theme:Gene_or_gene_productt6interceding-token ngrams: % co-immunoprecipitated witht7e2: args2Role-mention-ngram: that co-immunoprecipitatedt_e2: trigger-arg-path: co-immunoprecipitated:Binding nsubj [lemma='it'] themet$interceding-token ngrams: caveolin .tPe2: trigger-arg-path: co-immunoprecipitated:Binding prep_with [lemma='cd55'] theme:Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >nsubj themetWe2: trigger-arg-path: co-immunoprecipitated prep_with [lemma='cd55'] theme:Gene_or_gene_productt#interceding-token ngrams: with PDGFt9e1: ents2Label-mention-ngram: SHARED coimmunoprecipitatedt@e1: trigger-arg-path: coimmunoprecipitated >nsubj Generic_entitytpe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding nsubj [lemma='it'] Generic_entityt-interceding-token ngrams: Following treatmenttinterceding-token ngrams: PDGFtRe1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='cd55'] themet?e2: ents2Label-mention-ngram: SHARED that co-immunoprecipitatedtinterceding-token ngrams: raftst=e2: ents2Label-mention-ngram: that co-immunoprecipitated withtge1: trigger-arg-path: coimmunoprecipitated:Binding >prep_with [lemma='cd55'] theme:Gene_or_gene_producttMe1: trigger-arg-path: coimmunoprecipitated >nsubj [lemma='it'] Generic_entityt$interceding-token ngrams: and only 3tde2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding >prep_with [lemma='cd55'] themetIe2: trigger-arg-path: Binding prep_with [lemma='cd55'] themet'e2: args2Role-mention-ngram: THEME thatt?e1: trigger-arg-path: coimmunoprecipitated:Binding >nsubj themetLe2: trigger-arg-path: Binding >prep_with [lemma='cd55'] Gene_or_gene_productt'interceding-token ngrams: marker of nontinterceding-token ngrams: 3 %t%interceding-token ngrams: with PDGF ,t interceding-token ngrams: only 3tJe1: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='cd55'] themet[e1: trigger-arg-path: lemmatizedTrigger=coimmunoprecipitate >prep_with [lemma='cd55'] themet)interceding-token ngrams: with caveolin .tQe2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding nsubj Generic_entitytne2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate nsubj [lemma='it'] theme:Generic_entityt'interceding-token ngrams: with caveolintae2: trigger-arg-path: lemmatizedTrigger=co-immunoprecipitate:Binding prep_with [lemma='cd55'] themet$interceding-token ngrams: , and onlyt[e1: trigger-arg-path: coimmunoprecipitated:Binding >nsubj [lemma='it'] theme:Generic_entityt_e1: trigger-arg-path: coimmunoprecipitated >prep_with [lemma='cd55'] theme:Gene_or_gene_productt0e2: args2Role-mention-ngram: directly with THEMEt/e2: args2Role-mention-ngram: interacts directlytPe2: trigger-arg-path: Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttinterceding-token ngrams: ; onet.e1: args2Role-mention-ngram: THEME directly ortNe2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] themet-interceding-token ngrams: study reported thatt4e1: ents2Label-mention-ngram: directly or indirectlytRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf6'] themet*e2: args2Role-mention-ngram: directly withtVe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] themet-e1: args2Role-mention-ngram: indirectly bindstJe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf6'] themet5e1: ents2Label-mention-ngram: indirectly binds FAMILYtae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf6'] Gene_or_gene_producttJe2: trigger-arg-path: Binding >nsubj [lemma='rassf6'] Gene_or_gene_productt,interceding-token ngrams: one study reportedt1e1: ents2Label-mention-ngram: or indirectly bindstke2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: binds FAMILYtrshortest-path: parataxis [lemma='report'] >ccomp [lemma='interact'] >nsubj [lemma='rassf6']t@interceding-tokens-full-span: proteins ; one study reported thatt+e1: ents2Label-mention-ngram: or indirectlyt;e2: trigger-arg-path: Binding >nsubj [lemma='rassf6'] themetHe1: trigger-arg-path: binds >nsubj [lemma='rassf6'] Gene_or_gene_productt=e2: trigger-arg-path: interacts >nsubj [lemma='rassf6'] themet.shortest-path: parataxis >ccomp >nsubjt%interceding-token ngrams: ; one studytVe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt0e1: args2Role-mention-ngram: or indirectly bindstRe2: trigger-arg-path: interacts >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttEe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] themet0e1: ents2Label-mention-ngram: SHARED directly ortttrigger-to-trigger-path: e1:binds:Binding >parataxis [lemma='report'] >ccomp [lemma='interact'] e2:interacts:BindingtYe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf6'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt5e2: args2Role-mention-ngram: THEME interacts directlytAe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf6'] themetPtrigger-to-trigger-path: e1:binds:Binding >parataxis >ccomp e2:interacts:Bindingt(interceding-token ngrams: proteins ; onet$interceding-token ngrams: proteins ;tLe2: trigger-arg-path: interacts >nsubj [lemma='rassf6'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rassf6'] Gene_or_gene_productt4e2: args2Role-mention-ngram: interacts directly witht'e1: args2Role-mention-ngram: indirectlytNe1: trigger-arg-path: binds >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt*e1: args2Role-mention-ngram: or indirectlyt(e1: ents2Label-mention-ngram: indirectlyt_e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt3e1: args2Role-mention-ngram: directly or indirectlytZe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] theme:Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >nsubj [lemma='rassf6'] Gene_or_gene_producttTe2: trigger-arg-path: interacts:Binding >nsubj [lemma='rassf6'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: indirectly bindst@e2: ents2Label-mention-ngram: directly with GENE_OR_GENE_PRODUCTtce2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rassf6'] Gene_or_gene_productt9e1: trigger-arg-path: binds >nsubj [lemma='rassf6'] themet3e1: args2Role-mention-ngram: indirectly binds THEMEt interceding-token ngrams: ) , ast1interceding-token ngrams: inhibition of APC-Cdc20t,interceding-token ngrams: subsequently showntre1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of controlled:Gene_or_gene_producttqe1: trigger-arg-path: sequestration:Negative_activation agent [lemma='emi1'] controllert'interceding-token ngrams: RASSF1A takest*interceding-token ngrams: termed C19ORF5 )t2interceding-token ngrams: mitosis was subsequentlyt+e2: ents2Label-mention-ngram: 's binding tot^e1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of controlled:Gene_or_gene_productt#interceding-token ngrams: C19ORF5 )t/interceding-token ngrams: both the localizationtZe1: trigger-arg-path: sequestration:Negative_activation agent Gene_or_gene_productt(interceding-token ngrams: RBP1 preventedt(interceding-token ngrams: termed C19ORF5t0interceding-token ngrams: prometaphase , RASSF1At`e1: trigger-arg-path: sequestration:Negative_activation >prep_of controlled:Gene_or_gene_producttinterceding-token ngrams: RBP1t*e1: args2Role-mention-ngram: sequestrationt@e2: trigger-arg-path: binding >nsubj [lemma='it'] Generic_entitytge1: trigger-arg-path: sequestration agent [lemma='emi1'] Gene_or_gene_productt#interceding-token ngrams: , RASSF1At+interceding-token ngrams: binding protein 1t0interceding-token ngrams: was subsequently showntinterceding-token ngrams: , G 2t,interceding-token ngrams: by RASSF1A bindingt?e1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of [lemma='cdc20'] controlled:Gene_or_gene_producttye1: trigger-arg-path: lemmatizedTrigger=sequestration agent [lemma='emi1'] Gene_or_gene_producttQe1: trigger-arg-path: sequestration agent controller:Gene_or_gene_productt(interceding-token ngrams: , and prophaset%interceding-token ngrams: the spindletDe2: trigger-arg-path: binding:Binding >prep_to [lemma='cdc20'] themetNe1: trigger-arg-path: lemmatizedTrigger=sequestration agent controllert%interceding-token ngrams: then duringtKe2: trigger-arg-path: Binding >prep_to [lemma='cdc20'] Gene_or_gene_productt$interceding-token ngrams: of RASSF1At interceding-token ngrams: ( RBP1tNe2: trigger-arg-path: binding:Binding >nsubj [lemma='it'] theme:Generic_entityt(interceding-token ngrams: and prophase ,twe1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent controller:Gene_or_gene_producttRe1: trigger-arg-path: Negative_activation >prep_of controlled:Gene_or_gene_productt#interceding-token ngrams: . RASSF1Atme1: trigger-arg-path: Negative_activation agent [lemma='emi1'] Gene_or_gene_producttKe2: trigger-arg-path: binding >prep_to [lemma='cdc20'] Gene_or_gene_producttYe2: trigger-arg-path: binding:Binding >prep_to [lemma='cdc20'] theme:Gene_or_gene_producttagent controllert?e1: trigger-arg-path: sequestration:Negative_activation agent [lemma='emi1'] controller:Gene_or_gene_producttFe1: trigger-arg-path: sequestration agent Gene_or_gene_producttinterceding-token ngrams: Cdc20t+interceding-token ngrams: of RBP1 preventedt%interceding-token ngrams: regulator )t!interceding-token ngrams: mitosist?e1: trigger-arg-path: lemmatizedTrigger=sequestration agent [lemma='emi1'] controller:Gene_or_gene_productt-interceding-token ngrams: ; previously termedtprep_to [lemma='cdc20'] themet+interceding-token ngrams: spindle poles andt'interceding-token ngrams: regulator ) .t%interceding-token ngrams: role of thet3interceding-token ngrams: APC-Cdc20 activity duringt/e2: ents2Label-mention-ngram: GENERIC_ENTITY 'st1interceding-token ngrams: RASSF1A binding proteint?e1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent [lemma='emi1'] Gene_or_gene_productt,interceding-token ngrams: during mitosis wastSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdc20'] themet,interceding-token ngrams: mediated depletiont(interceding-token ngrams: during mitosist&interceding-token ngrams: of the Cdc20tce1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='cdc20'] Gene_or_gene_productt,interceding-token ngrams: prevented both thetce1: trigger-arg-path: Negative_activation agent [lemma='emi1'] controllert1interceding-token ngrams: RNAi mediated depletiontinterceding-token ngrams: GtWe1: trigger-arg-path: Negative_activation agent controller:Gene_or_gene_productt-e2: args2Role-mention-ngram: THEME 's bindingtKe1: trigger-arg-path: sequestration:Negative_activation >prep_of controlledt%interceding-token ngrams: on the rolet$interceding-token ngrams: by RASSF1At$interceding-token ngrams: prophase ,tme1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of [lemma='cdc20'] controlledt&interceding-token ngrams: takes on thet\e1: trigger-arg-path: sequestration >prep_of [lemma='cdc20'] controlled:Gene_or_gene_productt2e2: trigger-arg-path: binding:Binding >nsubj themet?e1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent [lemma='emi1'] controller:Gene_or_gene_productt(interceding-token ngrams: to the spindletbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdc20'] Gene_or_gene_producttFe2: trigger-arg-path: binding >nsubj [lemma='it'] theme:Generic_entityt'e2: args2Role-mention-ngram: 's bindingt&interceding-token ngrams: . RASSF1A 'stge1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of Gene_or_gene_productt&interceding-token ngrams: ; previouslytHe2: trigger-arg-path: binding:Binding >nsubj [lemma='it'] Generic_entityt!interceding-token ngrams: of RBP1tinterceding-token ngrams: Stinterceding-token ngrams: G 2 ,tZe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdc20'] Gene_or_gene_productt/interceding-token ngrams: RASSF1A 's inhibitiont.e1: ents2Label-mention-ngram: sequestration oft"interceding-token ngrams: ( RBP1 ;t%interceding-token ngrams: C19ORF5 ) ,toe1: trigger-arg-path: lemmatizedTrigger=sequestration agent [lemma='emi1'] controllertLe1: trigger-arg-path: Negative_activation agent Gene_or_gene_productt+interceding-token ngrams: RBP1 ; previouslyt=e1: trigger-arg-path: Negative_activation >prep_of controlledtSe1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of Gene_or_gene_productt%interceding-token ngrams: mitosis wast{e1: trigger-arg-path: sequestration:Negative_activation agent [lemma='emi1'] Gene_or_gene_productt$interceding-token ngrams: during S ,t]e1: trigger-arg-path: sequestration agent [lemma='emi1'] controllert(interceding-token ngrams: RASSF1A to thet-interceding-token ngrams: during prometaphaset(interceding-token ngrams: prometaphase ,t1interceding-token ngrams: activity during mitosistinterceding-token ngrams: polest'interceding-token ngrams: RNAi mediatedt7e2: trigger-arg-path: binding >nsubj [lemma='it'] themetee1: trigger-arg-path: sequestration:Negative_activation >prep_of [lemma='cdc20'] Gene_or_gene_producttxe1: trigger-arg-path: Negative_activation agent [lemma='emi1'] controller:Gene_or_gene_productt)interceding-token ngrams: activity duringt)interceding-token ngrams: to be regulatedtXe1: trigger-arg-path: lemmatizedTrigger=sequestration agent Gene_or_gene_productt#interceding-token ngrams: APC-Cdc20t(e2: ents2Label-mention-ngram: 's bindingt$interceding-token ngrams: RASSF1A 'st%interceding-token ngrams: ) . RASSF1At'interceding-token ngrams: 's inhibitionte1: trigger: sequestrationt)interceding-token ngrams: , RASSF1A takest[e1: trigger-arg-path: sequestration:Negative_activation >prep_of [lemma='cdc20'] controlledt7e2: ents2Label-mention-ngram: GENERIC_ENTITY 's bindingt*interceding-token ngrams: was subsequentlytQe2: trigger-arg-path: binding >prep_to [lemma='cdc20'] theme:Gene_or_gene_productt'interceding-token ngrams: , then duringt!interceding-token ngrams: as RNAit/interceding-token ngrams: of APC-Cdc20 activityt2interceding-token ngrams: then during prometaphaset(interceding-token ngrams: prevented botht"interceding-token ngrams: during Stwe1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of [lemma='cdc20'] Gene_or_gene_productt-interceding-token ngrams: RBP1 prevented bothtGe1: trigger-arg-path: sequestration >prep_of [lemma='cdc20'] controlledt"interceding-token ngrams: prophaset?interceding-tokens-full-span: during S , G 2 , and prophase , then during prometaphase , RASSF1A takes on the role of the Cdc20 regulator ) . RASSF1A 's inhibition of APC-Cdc20 activity during mitosis was subsequently shown to be regulated by RASSF1A binding protein 1 ( RBP1 ; previously termed C19ORF5 ) , as RNAi mediated depletion of RBP1 prevented both the localization of RASSF1A to the spindle poles andt.interceding-token ngrams: regulated by RASSF1AtAe2: trigger-arg-path: binding:Binding >nsubj theme:Generic_entityt3e2: trigger-arg-path: binding >nsubj Generic_entitytle1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent Gene_or_gene_productt+interceding-token ngrams: depletion of RBP1tMe1: trigger-arg-path: Negative_activation >prep_of [lemma='cdc20'] controlledtPe1: trigger-arg-path: sequestration:Negative_activation agent controllert&interceding-token ngrams: prometaphaset$interceding-token ngrams: RASSF1A tot interceding-token ngrams: , thent-e1: args2Role-mention-ngram: sequestration oftSe2: trigger-arg-path: binding:Binding >prep_to [lemma='cdc20'] Gene_or_gene_productt"interceding-token ngrams: 1 ( RBP1t*interceding-token ngrams: RASSF1A takes ont/interceding-token ngrams: during prometaphase ,t3interceding-token ngrams: previously termed C19ORF5tre1: trigger-arg-path: sequestration agent [lemma='emi1'] controller:Gene_or_gene_productt;e2: trigger-arg-path: binding:Binding >nsubj Generic_entityt)interceding-token ngrams: RASSF1A bindingt5e1: ents2Label-mention-ngram: sequestration of SHAREDtpe1: trigger-arg-path: sequestration:Negative_activation >prep_of [lemma='cdc20'] controlled:Gene_or_gene_producttinterceding-token ngrams: S , Gt7e1: trigger-arg-path: sequestration >prep_of controlledtQe1: trigger-arg-path: sequestration >prep_of [lemma='cdc20'] Gene_or_gene_productt%interceding-token ngrams: protein 1 (tprep_to [lemma='cdc20'] themet/interceding-token ngrams: subsequently shown tot-interceding-token ngrams: the Cdc20 regulatort*interceding-token ngrams: as RNAi mediatedtce1: trigger-arg-path: lemmatizedTrigger=sequestration agent controller:Gene_or_gene_productt)interceding-token ngrams: Cdc20 regulatortbe1: trigger-arg-path: Negative_activation >prep_of [lemma='cdc20'] controlled:Gene_or_gene_producttGe1: trigger-arg-path: Negative_activation >prep_of Gene_or_gene_producttinterceding-token ngrams: S ,t!interceding-token ngrams: C19ORF5t8e1: args2Role-mention-ngram: sequestration of CONTROLLEDt)interceding-token ngrams: prophase , thent e2: ents2Label-mention-ngram: 'stLe1: trigger-arg-path: sequestration >prep_of controlled:Gene_or_gene_productt+interceding-token ngrams: previously termedt+e1: ents2Label-mention-ngram: sequestrationtQe2: trigger-arg-path: Binding >prep_to [lemma='cdc20'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: 's binding tot'interceding-token ngrams: of RASSF1A tot+interceding-token ngrams: Cdc20 regulator )t?e1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent [lemma='emi1'] controllert&interceding-token ngrams: and prophasetinterceding-token ngrams: RNAit]e1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation >prep_of controlledtinterceding-token ngrams: G 2tbe1: trigger-arg-path: lemmatizedTrigger=sequestration:Negative_activation agent controllert#interceding-token ngrams: , as RNAitinterceding-token ngrams: , Gt1interceding-token ngrams: localization of RASSF1At+interceding-token ngrams: the spindle polest*e2: trigger-arg-path: binding >nsubj themet'interceding-token ngrams: spindle polest&interceding-token ngrams: of APC-Cdc20tIe1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of controlledt interceding-token ngrams: RBP1 ;t?e2: trigger-arg-path: binding:Binding >nsubj [lemma='it'] themet%e2: args2Role-mention-ngram: THEME 'st*interceding-token ngrams: 's inhibition oft#interceding-token ngrams: poles andt`e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdc20'] theme:Gene_or_gene_producttLCSSPATH: ROOT >xcomp >ccomp >parataxis >agent ++ ROOT >xcomp >dobj >dep >deptYe1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='cdc20'] controlledtinterceding-token ngrams: takesthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdc20'] theme:Gene_or_gene_producttUe1: trigger-arg-path: sequestration:Negative_activation >prep_of Gene_or_gene_productt,interceding-token ngrams: APC-Cdc20 activityt9e2: trigger-arg-path: binding >nsubj theme:Generic_entitytee1: trigger-arg-path: sequestration:Negative_activation agent controller:Gene_or_gene_productt"interceding-token ngrams: takes ont!interceding-token ngrams: spindletWe1: trigger-arg-path: Negative_activation >prep_of [lemma='cdc20'] Gene_or_gene_productt#interceding-token ngrams: the Cdc20tAe1: trigger-arg-path: sequestration >prep_of Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdc20'] themetne1: trigger-arg-path: lemmatizedTrigger=sequestration >prep_of [lemma='cdc20'] controlled:Gene_or_gene_productt/interceding-token ngrams: mediated depletion oftBe1: trigger-arg-path: Negative_activation agent controllerte2: args2Role-mention-ngram: 'st-e1: ents2Label-mention-ngram: and RASSF1C cant1e2: args2Role-mention-ngram: RASSF1C can interactt_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] Gene_or_gene_producttFe1: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] themetme2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt.e1: args2Role-mention-ngram: THEME and RASSF1Ct2e2: ents2Label-mention-ngram: RASSF1C can interacttLe1: trigger-arg-path: Binding >prep_with [lemma='cnk1'] Gene_or_gene_producttMe1: trigger-arg-path: interact >prep_with [lemma='cnk1'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] themetme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] Gene_or_gene_producttee2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] theme:Gene_or_gene_producttLe1: trigger-arg-path: interact >nsubj [lemma='rassf1a'] Gene_or_gene_productt[e1: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt)e2: ents2Label-mention-ngram: RASSF1C cant=e1: trigger-arg-path: Binding >prep_with [lemma='cnk1'] themet=e2: trigger-arg-path: Binding >prep_with [lemma='cnk1'] themetMe2: trigger-arg-path: interact >prep_with [lemma='cnk1'] Gene_or_gene_producttZe1: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] themetXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] themetSe2: trigger-arg-path: interact >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt[e2: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] themet2e1: ents2Label-mention-ngram: RASSF1C can interacttge2: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: RASSF1C cant(e2: args2Role-mention-ngram: RASSF1C cant)e2: ents2Label-mention-ngram: and RASSF1Ct_e2: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] Gene_or_gene_producttRe1: trigger-arg-path: interact >nsubj [lemma='rassf1a'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='cnk1'] Gene_or_gene_productt(e2: args2Role-mention-ngram: and RASSF1Ct%e2: ents2Label-mention-ngram: RASSF1Ct0e1: ents2Label-mention-ngram: SHARED and RASSF1CtRe2: trigger-arg-path: Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_producttEe1: trigger-arg-path: interact:Binding >nsubj [lemma='rassf1a'] themetFe2: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] themet%e1: ents2Label-mention-ngram: RASSF1Ct$e1: args2Role-mention-ngram: RASSF1Ct.e2: args2Role-mention-ngram: THEME and RASSF1Ctee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt=e1: trigger-arg-path: interact >nsubj [lemma='rassf1a'] themet>e1: trigger-arg-path: interact >prep_with [lemma='cnk1'] themetSe1: trigger-arg-path: interact >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt,e1: args2Role-mention-ngram: and RASSF1C cant)e1: ents2Label-mention-ngram: and RASSF1Ct-e2: ents2Label-mention-ngram: and RASSF1C cant(e1: args2Role-mention-ngram: RASSF1C cant1e1: args2Role-mention-ngram: RASSF1C can interactt0e2: ents2Label-mention-ngram: SHARED and RASSF1CtUe1: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] Gene_or_gene_productt,e2: args2Role-mention-ngram: and RASSF1C cant>e2: trigger-arg-path: interact >prep_with [lemma='cnk1'] themet$e2: args2Role-mention-ngram: RASSF1CtUe2: trigger-arg-path: interact:Binding >prep_with [lemma='cnk1'] Gene_or_gene_producttLe2: trigger-arg-path: Binding >prep_with [lemma='cnk1'] Gene_or_gene_productt(e1: args2Role-mention-ngram: and RASSF1CtRe1: trigger-arg-path: Binding >prep_with [lemma='cnk1'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: apoptosis inducingt6e1: args2Role-mention-ngram: apoptosis inducing ligandt"e1: args2Role-mention-ngram: TRAILt-e1: args2Role-mention-ngram: MAP-1 ) proteinst%e1: args2Role-mention-ngram: inducingtve1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controllerthe1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >prep_of Gene_or_gene_productt+e1: ents2Label-mention-ngram: complexes andt/e1: ents2Label-mention-ngram: TNFalpha ( tumourtke2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt'e1: args2Role-mention-ngram: of RASSF1Atse2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themetNe2: trigger-arg-path: recruitment >prep_of >prep_of theme:Gene_or_gene_productt*e1: ents2Label-mention-ngram: the receptort?e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controller:Gene_or_gene_productt(e1: ents2Label-mention-ngram: ) resultedt#e1: ents2Label-mention-ngram: alphat'e1: args2Role-mention-ngram: alpha ) ort/e2: args2Role-mention-ngram: modulator of THEMEt&e1: ents2Label-mention-ngram: inducingtce2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] Gene_or_gene_productt%e1: args2Role-mention-ngram: TNFalphat4e1: args2Role-mention-ngram: and promoted CONTROLLEDtbe1: trigger-arg-path: promoted >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controllert"e1: args2Role-mention-ngram: alphat"e1: args2Role-mention-ngram: MAP-1t(e1: ents2Label-mention-ngram: of RASSF1At.e1: args2Role-mention-ngram: inducing ligand (t#e1: ents2Label-mention-ngram: MAP-1t+e2: ents2Label-mention-ngram: and modulatort)e1: args2Role-mention-ngram: and promotedtKe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of themet.e1: ents2Label-mention-ngram: promoted complext9e1: trigger-arg-path: promoted >nsubj >prep_of controllert)e1: ents2Label-mention-ngram: RASSF1A andt.e2: ents2Label-mention-ngram: and modulator oft)e1: ents2Label-mention-ngram: proteins tot&e1: ents2Label-mention-ngram: TNFalphat3e1: args2Role-mention-ngram: receptor complexes andt+e1: args2Role-mention-ngram: of apoptosis-1tWe1: trigger-arg-path: promoted:Positive_regulation >nsubj >prep_of Gene_or_gene_producttPe2: trigger-arg-path: recruitment:Binding >prep_of >prep_of Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet+e1: ents2Label-mention-ngram: with TNFalphat+e1: args2Role-mention-ngram: ligand ( TRAILt2e2: ents2Label-mention-ngram: SHARED and modulatort4e1: ents2Label-mention-ngram: receptor complexes andtTe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] themet/e1: ents2Label-mention-ngram: related apoptosistDe2: trigger-arg-path: Binding >prep_of >prep_of Gene_or_gene_productt'e1: args2Role-mention-ngram: ) resultedt\e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] themet+e1: args2Role-mention-ngram: of RASSF1A andt-e1: ents2Label-mention-ngram: with TNFalpha (t#e1: ents2Label-mention-ngram: TRAILtVe2: trigger-arg-path: recruitment:Binding >prep_of >prep_of theme:Gene_or_gene_producttpe2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: TNFalpha relatedtQe2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: apoptosis inducingt?e1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: necrosis factort0e2: args2Role-mention-ngram: THEME and modulatort,e1: args2Role-mention-ngram: proteins to thet)e1: ents2Label-mention-ngram: resulted int?e1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: ) resulted int}e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] Gene_or_gene_productt7e1: args2Role-mention-ngram: related apoptosis inducingt_e1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >prep_of controller:Gene_or_gene_productt)e1: ents2Label-mention-ngram: apoptosis-1t%e1: args2Role-mention-ngram: ( tumourt1e1: ents2Label-mention-ngram: apoptosis-1 ( MAP-1t2e1: args2Role-mention-ngram: necrosis factor alphatre2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt"e1: ents2Label-mention-ngram: ) ortJe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] themetae2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet.e1: ents2Label-mention-ngram: TRAIL ) resultedtie2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: ( tumour necrosist&e1: ents2Label-mention-ngram: ( tumourt3e1: ents2Label-mention-ngram: necrosis factor alphat*e1: args2Role-mention-ngram: ) or TNFalphat/e1: ents2Label-mention-ngram: in recruitment oft?e2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt.e1: ents2Label-mention-ngram: of apoptosis-1 (t+e1: args2Role-mention-ngram: factor alpha )tbe1: trigger-arg-path: promoted:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt7e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT withtbtrigger-to-trigger-path: e1:promoted:Positive_regulation prep_in e2:recruitment:Bindingtqe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: ( TRAIL )t3e1: ents2Label-mention-ngram: RASSF1A and modulatort*e1: ents2Label-mention-ngram: and promotedt(e1: args2Role-mention-ngram: RASSF1A andt8e1: ents2Label-mention-ngram: related apoptosis inducingt%e1: ents2Label-mention-ngram: RASSF1At%e1: ents2Label-mention-ngram: TRAIL )t?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: TRAIL )t$e1: args2Role-mention-ngram: RASSF1At5e1: ents2Label-mention-ngram: resulted in recruitmentt*e1: ents2Label-mention-ngram: factor alphatJe2: trigger-arg-path: Binding >prep_of >prep_of theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: to the receptort+e1: args2Role-mention-ngram: in recruitmentt(e1: args2Role-mention-ngram: proteins totTe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >prep_of Gene_or_gene_producttYe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] Gene_or_gene_productt-e1: args2Role-mention-ngram: TNFalpha relatedt,e1: args2Role-mention-ngram: inducing ligandt5e1: args2Role-mention-ngram: CONTROLLER with TNFalphatle2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt*e1: args2Role-mention-ngram: complexes andt%e1: args2Role-mention-ngram: resultedt'e1: ents2Label-mention-ngram: ( TRAIL )t~e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt6e1: ents2Label-mention-ngram: modulator of apoptosis-1tve2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt_e2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productt2e1: args2Role-mention-ngram: RASSF1A and modulatort^e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controllert{shortest-path: prep_in [lemma='recruitment']t-e2: args2Role-mention-ngram: and modulator oft&e1: args2Role-mention-ngram: ( MAP-1 )t?trigger-to-trigger-path: e1:promoted:Positive_regulation prep_in [lemma='recruitment'] e2:recruitment:Bindingt,e1: ents2Label-mention-ngram: ligand ( TRAILt+shortest-path: prep_int,e1: ents2Label-mention-ngram: of apoptosis-1t+e1: ents2Label-mention-ngram: ) proteins tot*e2: ents2Label-mention-ngram: modulator oftie2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themet-e1: args2Role-mention-ngram: TRAIL ) resultedt(e1: args2Role-mention-ngram: resulted int&e1: ents2Label-mention-ngram: resultedt7e1: args2Role-mention-ngram: TNFalpha related apoptosist/e1: ents2Label-mention-ngram: inducing ligand (t)e1: ents2Label-mention-ngram: or TNFalphat(e1: args2Role-mention-ngram: apoptosis-1t)e1: args2Role-mention-ngram: the receptort0e1: args2Role-mention-ngram: apoptosis-1 ( MAP-1t5e1: args2Role-mention-ngram: modulator of apoptosis-1t*e1: args2Role-mention-ngram: with TNFalphat(e1: args2Role-mention-ngram: or TNFalphat8e1: ents2Label-mention-ngram: promoted complex formationtwe1: trigger-arg-path: promoted >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controller:Gene_or_gene_productt1e1: ents2Label-mention-ngram: or TNFalpha relatedt2e1: ents2Label-mention-ngram: and promoted complextle1: trigger-arg-path: promoted >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] Gene_or_gene_producttHe2: trigger-arg-path: recruitment >prep_of >prep_of Gene_or_gene_productt-e1: args2Role-mention-ngram: of apoptosis-1 (t,e1: ents2Label-mention-ngram: of RASSF1A andt.e1: args2Role-mention-ngram: TNFalpha ( tumourt3e1: args2Role-mention-ngram: the receptor complexest7e1: ents2Label-mention-ngram: apoptosis inducing ligandt,e1: args2Role-mention-ngram: tumour necrosist3e1: args2Role-mention-ngram: complexes and promotedtbe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of Gene_or_gene_productt+e1: ents2Label-mention-ngram: apoptosis-1 (tse1: trigger-arg-path: lemmatizedTrigger=promote >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controllert?e1: trigger-arg-path: promoted:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: the receptor complexest&e2: args2Role-mention-ngram: modulatort@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT with TNFalphat8e1: ents2Label-mention-ngram: TNFalpha related apoptosist'e2: ents2Label-mention-ngram: modulatort4e1: args2Role-mention-ngram: resulted in recruitmentt9e2: trigger-arg-path: recruitment >prep_of >prep_of themet,e1: ents2Label-mention-ngram: factor alpha )tBe2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] themet3e1: args2Role-mention-ngram: recruitment of RASSF1At'e1: args2Role-mention-ngram: TNFalpha (tNe1: trigger-arg-path: promoted >nsubj >prep_of controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: receptor complexest3e1: args2Role-mention-ngram: tumour necrosis factort$e1: args2Role-mention-ngram: ( TRAILt$e1: ents2Label-mention-ngram: tumourtZe2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of >prep_of Gene_or_gene_producttwe1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: complexes and promotedt$e1: args2Role-mention-ngram: alpha )tme1: trigger-arg-path: Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] controllertWe2: trigger-arg-path: recruitment >prep_of [lemma='rassf1a'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of theme:Gene_or_gene_productt4e1: ents2Label-mention-ngram: tumour necrosis factort%e1: ents2Label-mention-ngram: MAP-1 )tCe1: trigger-arg-path: promoted >nsubj >prep_of Gene_or_gene_productt.e1: ents2Label-mention-ngram: MAP-1 ) proteinst.e1: args2Role-mention-ngram: related apoptosist(e1: ents2Label-mention-ngram: TNFalpha (t?e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: ( MAP-1t$e1: args2Role-mention-ngram: ( MAP-1t$e1: args2Role-mention-ngram: MAP-1 )t)e2: args2Role-mention-ngram: modulator oft4e1: ents2Label-mention-ngram: recruitment of RASSF1At,e1: ents2Label-mention-ngram: in recruitmentt?e2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: proteins to thet'e1: ents2Label-mention-ngram: ( MAP-1 )t+e1: ents2Label-mention-ngram: ) resulted int%e1: args2Role-mention-ngram: necrosist]e2: trigger-arg-path: Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] themetAe2: trigger-arg-path: recruitment:Binding >prep_of >prep_of themetxe2: trigger-arg-path: recruitment:Binding >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] Gene_or_gene_productt0e1: args2Role-mention-ngram: or TNFalpha relatedt,e1: args2Role-mention-ngram: necrosis factortJe1: trigger-arg-path: lemmatizedTrigger=promote >nsubj >prep_of controllert*e1: args2Role-mention-ngram: apoptosis-1 (t,e1: args2Role-mention-ngram: to the receptort.e1: args2Role-mention-ngram: ( tumour necrosistSe2: trigger-arg-path: lemmatizedTrigger=recruitment:Binding >prep_of >prep_of themet%e1: args2Role-mention-ngram: ligand (t&e1: ents2Label-mention-ngram: necrosistMe1: trigger-arg-path: promoted:Positive_regulation >nsubj >prep_of controllert+e1: ents2Label-mention-ngram: ) or TNFalphat!e1: args2Role-mention-ngram: ) ort%e1: ents2Label-mention-ngram: ( TRAILt0e1: ents2Label-mention-ngram: receptor complexest,e1: args2Role-mention-ngram: with TNFalpha (t.e1: args2Role-mention-ngram: in recruitment oftse1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt-e1: ents2Label-mention-ngram: inducing ligandt5e2: trigger-arg-path: Binding >prep_of >prep_of themet#e1: args2Role-mention-ngram: tumourt?e2: trigger-arg-path: lemmatizedTrigger=recruitment >prep_of [lemma='rassf1a'] >prep_of [lemma='apoptosis-1'] theme:Gene_or_gene_productt-e1: ents2Label-mention-ngram: tumour necrosist)e1: args2Role-mention-ngram: factor alphat?e1: trigger-arg-path: lemmatizedTrigger=promote:Positive_regulation >nsubj [lemma='stimulation'] >prep_of [lemma='receptor'] Gene_or_gene_productt?e2: ents2Label-mention-ngram: modulator of GENE_OR_GENE_PRODUCTt%e1: ents2Label-mention-ngram: alpha )t*e2: args2Role-mention-ngram: and modulatort*e1: args2Role-mention-ngram: ) proteins tot&e1: ents2Label-mention-ngram: ligand (t(e1: ents2Label-mention-ngram: alpha ) ortWe1: trigger-arg-path: activate:Positive_activation >dobj [lemma='p110gamma'] controlledt,e1: trigger-arg-path: activate >nsubj Familytle1: trigger-arg-path: activate:Positive_activation >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt6CSSPATH: ROOT >vmod >ccomp ++ ROOT >agent >rcmod >dobjtDe1: trigger-arg-path: activate >nsubj [lemma='ra'] controller:Familyt1e1: ents2Label-mention-ngram: SHARED can activatet=e1: trigger-arg-path: activate >nsubj [lemma='ra'] controllertKe1: trigger-arg-path: activate:Positive_activation >nsubj controller:FamilytMe1: trigger-arg-path: activate >dobj [lemma='p110gamma'] Gene_or_gene_producttinterceding-tokens-full-span: without its membrane translocation . This view is supported by structural work that has suggestedtQe1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='ra'] controllertXe1: trigger-arg-path: activate >dobj [lemma='p110gamma'] controlled:Gene_or_gene_productt7e1: trigger-arg-path: activate >nsubj controller:FamilytMe1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='ra'] FamilytCe1: trigger-arg-path: activate >dobj [lemma='p110gamma'] controlledtXe1: trigger-arg-path: activate:Positive_activation >nsubj [lemma='ra'] controller:Familytae1: trigger-arg-path: activate:Positive_activation >dobj [lemma='p110gamma'] Gene_or_gene_productt9e1: trigger-arg-path: activate >nsubj [lemma='ra'] Familyt@e1: trigger-arg-path: activate:Positive_activation >nsubj Familytfe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='rapamycin'] controller:Simple_chemicaltTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicalt.e1: args2Role-mention-ngram: also concurrentlyt3e1: args2Role-mention-ngram: concurrently increasedt9e1: args2Role-mention-ngram: CONTROLLER also concurrentlytWe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='rapamycin'] controllertTe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rapamycin'] controllertVe1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='rapamycin'] controllert4e1: ents2Label-mention-ngram: concurrently increasedtYe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rapamycin'] Simple_chemicalt8e1: args2Role-mention-ngram: also concurrently increasedtie1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicaltde2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='rapamycin'] controller:Simple_chemicaltge2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicaltHe2: trigger-arg-path: induced >nsubj [lemma='rapamycin'] Simple_chemicalt6e1: ents2Label-mention-ngram: SHARED also concurrentlyt^e1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicaltxe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicalt_e2: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicaltje1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='rapamycin'] controllert[e1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='rapamycin'] Simple_chemicaltSe2: trigger-arg-path: induced >nsubj [lemma='rapamycin'] controller:Simple_chemicaltze1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicaltYe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='rapamycin'] controllert)e1: ents2Label-mention-ngram: of both AkttUe1: trigger-arg-path: increased >nsubj [lemma='rapamycin'] controller:Simple_chemicaltme2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicalt/e1: ents2Label-mention-ngram: also concurrentlyt;e1: ents2Label-mention-ngram: increased the phosphorylationtOe1: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] controllertCe2: trigger-arg-path: induced >nsubj [lemma='rapamycin'] controllertJe1: trigger-arg-path: increased >nsubj [lemma='rapamycin'] Simple_chemicaltOe2: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] controllert:e1: ents2Label-mention-ngram: Akt and GENE_OR_GENE_PRODUCTtoe1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicalt7e1: args2Role-mention-ngram: concurrently increased thet#interceding-tokens-full-span: . Thet5e1: ents2Label-mention-ngram: phosphorylation of botht_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] controller:Simple_chemicaltTe2: trigger-arg-path: Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicalt8e1: ents2Label-mention-ngram: concurrently increased thethe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='rapamycin'] controllert\e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='rapamycin'] Simple_chemicalt9e1: ents2Label-mention-ngram: also concurrently increasedtEe1: trigger-arg-path: increased >nsubj [lemma='rapamycin'] controllert(e2: ents2Label-mention-ngram: active Aktt$interceding-token ngrams: Expressiont)e2: ents2Label-mention-ngram: Akt inducedt$interceding-token ngrams: LY294002 .t?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt'e2: args2Role-mention-ngram: active Aktt1e1: ents2Label-mention-ngram: or IGF-I stimulatedtwe2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] controllert'e2: ents2Label-mention-ngram: or activet+interceding-token ngrams: of constitutivelyt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT or IGF-It%e1: args2Role-mention-ngram: or IGF-It4e1: ents2Label-mention-ngram: by the SIMPLE_CHEMICALt0e1: args2Role-mention-ngram: or IGF-I stimulatedt0e1: args2Role-mention-ngram: CONTROLLER or IGF-It&e1: ents2Label-mention-ngram: or IGF-ItDe1: trigger-arg-path: stimulated >nsubj [lemma='insulin'] controllert+e1: ents2Label-mention-ngram: was inhibitedtze2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] Gene_or_gene_productt3e2: args2Role-mention-ngram: Akt induced CONTROLLEDt2interceding-token ngrams: of constitutively activetNe1: trigger-arg-path: stimulated >nsubj [lemma='insulin'] Gene_or_gene_producttfe2: trigger-arg-path: induced >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] Gene_or_gene_productt*e2: args2Role-mention-ngram: or active Aktt(e2: args2Role-mention-ngram: Akt inducedtpe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controllert.e1: ents2Label-mention-ngram: was inhibited bytXe1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='insulin'] controllert"e1: args2Role-mention-ngram: IGF-It&e2: args2Role-mention-ngram: or activet#e1: ents2Label-mention-ngram: IGF-It1e1: ents2Label-mention-ngram: which was inhibitedt?e2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt)interceding-token ngrams: . Expression oftqe2: trigger-arg-path: induced >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controllert?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controllert+e2: ents2Label-mention-ngram: or active Aktt'interceding-token ngrams: Expression oftUe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] controllert_e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] Gene_or_gene_producttnsubj [lemma='insulin'] controller:Gene_or_gene_productt\e2: trigger-arg-path: induced >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controllert.e1: ents2Label-mention-ngram: IGF-I stimulatedt>e1: ents2Label-mention-ngram: IGF-I stimulated phosphorylationtre2: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productt8e1: args2Role-mention-ngram: IGF-I stimulated CONTROLLEDt?e2: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt0e2: ents2Label-mention-ngram: active Akt inducedt1e2: args2Role-mention-ngram: CONTROLLER or activetYe1: trigger-arg-path: stimulated >nsubj [lemma='insulin'] controller:Gene_or_gene_productt/interceding-token ngrams: LY294002 . Expressiont/e2: args2Role-mention-ngram: active Akt inducedt)e1: ents2Label-mention-ngram: , which wast0e2: ents2Label-mention-ngram: Akt induced SHAREDt&interceding-token ngrams: . Expressiont6interceding-token ngrams: Expression of constitutivelyt'e1: ents2Label-mention-ngram: which wast1e1: ents2Label-mention-ngram: the SIMPLE_CHEMICALtLinterceding-tokens-full-span: LY294002 . Expression of constitutively activetbe1: trigger-arg-path: stimulated:Positive_regulation >nsubj [lemma='insulin'] Gene_or_gene_productthe2: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controllert~e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='insulin'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: IGF-I stimulatedtje1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='insulin'] controller:Gene_or_gene_productt}e2: trigger-arg-path: Positive_regulation >nsubj [lemma='expression'] >prep_of [lemma='pi3k'] controller:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllert.e2: ents2Label-mention-ngram: was inhibited byt?trigger-to-trigger-path: e1:stimulated:Positive_regulation >dobj [lemma='phosphorylation'] >prep_of [lemma='tuberin'] >rcmod [lemma='inhibit'] e2:inhibited:Negative_regulationtwe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicaltpe2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e2: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationt?e2: trigger-arg-path: inhibited nsubj [lemma='igf-i'] controlled:Positive_regulationt{e2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt[e2: trigger-arg-path: inhibited:Negative_regulation nsubj controlledtQe2: trigger-arg-path: Negative_regulation nsubj controlledt[e2: trigger-arg-path: inhibited nsubj controlled:Positive_regulationtNe2: trigger-arg-path: inhibited:Negative_regulation >agent >nn Simple_chemicaltle2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] Positive_regulationt-e2: args2Role-mention-ngram: was inhibited bytie2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn controller:Simple_chemicaltte2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj Positive_regulationt?e2: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationt.e2: ents2Label-mention-ngram: inhibited by thetke2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controlledt?e2: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] controlledt)shortest-path: nsubj Positive_regulationtYe2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn controllertke2: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertke2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controlled:Positive_regulationtge2: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] controlledt?e2: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt`e2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj Positive_regulationtfe2: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt-e2: args2Role-mention-ngram: inhibited by thetMe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulated phosphorylationtYe2: trigger-arg-path: inhibited:Negative_regulation >agent >nn controller:Simple_chemicaltqe2: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] Positive_regulationtEe2: trigger-arg-path: inhibited >agent >nn controller:Simple_chemicalt?e2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] controlled:Positive_regulationt&e2: args2Role-mention-ngram: which wastoe2: trigger-arg-path: inhibited:Negative_regulation nsubj controlled:Positive_regulationt)e2: ents2Label-mention-ngram: , which wast'e2: ents2Label-mention-ngram: which wast1e2: ents2Label-mention-ngram: which was inhibitedtPe2: trigger-arg-path: inhibited nsubj Positive_regulationtGe2: trigger-arg-path: inhibited nsubj controlledtUe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn controller:Simple_chemicalt*e2: args2Role-mention-ngram: was inhibitedtqtrigger-to-trigger-path: e1:stimulated:Positive_regulation >dobj >prep_of >rcmod e2:inhibited:Negative_regulationt?e2: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationtDe2: trigger-arg-path: Negative_regulation >agent >nn Simple_chemicaltJe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn Simple_chemicaltWe2: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controlledt?e2: trigger-arg-path: inhibited nsubj [lemma='igf-i'] controlledtde2: trigger-arg-path: inhibited:Negative_regulation nsubj Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt?e2: trigger-arg-path: Negative_regulation >agent >nn controllertWe2: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertae2: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllert(e2: args2Role-mention-ngram: , which wast\e2: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e2: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] Positive_regulationtOe2: trigger-arg-path: Negative_regulation >agent >nn controller:Simple_chemicaltee2: trigger-arg-path: Negative_regulation nsubj controlled:Positive_regulationtge2: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllert:e2: trigger-arg-path: inhibited >agent >nn Simple_chemicalt?e2: trigger-arg-path: inhibited nsubj [lemma='igf-i'] Positive_regulationtEe2: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn controllert+e2: ents2Label-mention-ngram: was inhibitedt0e2: args2Role-mention-ngram: which was inhibitedte2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controlled:Positive_regulationt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] controlledt5e2: trigger-arg-path: inhibited >agent >nn controllertIe2: trigger-arg-path: inhibited:Negative_regulation >agent >nn controllert[e1: trigger-arg-path: inhibited nsubj controlled:Positive_regulationte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controlled:Positive_regulationt?e1: trigger-arg-path: inhibited nsubj [lemma='igf-i'] Positive_regulationt?e1: trigger-arg-path: inhibited nsubj [lemma='igf-i'] controlled:Positive_regulationt(e1: args2Role-mention-ngram: , which wast?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationtke1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj controlledt?e1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] controlled:Positive_regulationtEe1: trigger-arg-path: inhibited >agent >nn controller:Simple_chemicaltke1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertke1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controlled:Positive_regulationt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertWe1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj controlledt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationtge1: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt?e1: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] controlledt{e1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicaltYe1: trigger-arg-path: inhibited:Negative_regulation >agent >nn controller:Simple_chemicaltee1: trigger-arg-path: Negative_regulation nsubj controlled:Positive_regulationt3CSSPATH: ROOT >ccomp >dobj >prep_of >rcmod ++ ROOT tWe1: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertGe1: trigger-arg-path: inhibited nsubj controlledtYe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn controllert?e1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] Positive_regulationtEe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn controllertle1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] Positive_regulationt:e1: trigger-arg-path: inhibited >agent >nn Simple_chemicalt*e1: args2Role-mention-ngram: was inhibitedtQe1: trigger-arg-path: Negative_regulation nsubj controlledtDe1: trigger-arg-path: Negative_regulation >agent >nn Simple_chemicaltIe1: trigger-arg-path: inhibited:Negative_regulation >agent >nn controllertte1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj Positive_regulationtUe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn controller:Simple_chemicaltMe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT stimulated phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation nsubj [lemma='igf-i'] controlledtpe1: trigger-arg-path: inhibited:Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e1: trigger-arg-path: Negative_regulation >agent >nn controllertoe1: trigger-arg-path: inhibited:Negative_regulation nsubj controlled:Positive_regulationt-e1: args2Role-mention-ngram: was inhibited byt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] Positive_regulationt&e1: args2Role-mention-ngram: which wastPe1: trigger-arg-path: inhibited nsubj Positive_regulationtZe1: trigger-arg-path: Negative_regulation nsubj Positive_regulationt0e1: args2Role-mention-ngram: which was inhibitedtqe1: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicalt^e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn Simple_chemicalt/e1: args2Role-mention-ngram: CONTROLLED , whichtwe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] controller:Simple_chemicaltOe1: trigger-arg-path: Negative_regulation >agent >nn controller:Simple_chemicalt5e1: trigger-arg-path: inhibited >agent >nn controllertae1: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllert?e1: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] controlled:Positive_regulationt\e1: trigger-arg-path: inhibited >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicaltfe1: trigger-arg-path: Negative_regulation >agent [lemma='ly294002'] >nn [lemma='pi3k'] Simple_chemicalt?e1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj [lemma='igf-i'] controlledt?e1: trigger-arg-path: inhibited:Negative_regulation nsubj [lemma='igf-i'] Positive_regulationt?e1: trigger-arg-path: inhibited nsubj [lemma='igf-i'] controlledtde1: trigger-arg-path: inhibited:Negative_regulation nsubj Positive_regulationtie1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >agent >nn controller:Simple_chemicalt[e1: trigger-arg-path: inhibited:Negative_regulation nsubj controlledt`e1: trigger-arg-path: lemmatizedTrigger=inhibit nsubj Positive_regulationt-e1: args2Role-mention-ngram: inhibited by thetNe1: trigger-arg-path: inhibited:Negative_regulation >agent >nn Simple_chemicaltge1: trigger-arg-path: lemmatizedTrigger=inhibit >agent [lemma='ly294002'] >nn [lemma='pi3k'] controllertJe1: trigger-arg-path: lemmatizedTrigger=inhibit >agent >nn Simple_chemicalt?e1: trigger-arg-path: Negative_regulation nsubj [lemma='igf-i'] controlledtqe2: trigger-arg-path: Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] Gene_or_gene_productt#interceding-token ngrams: substratet&interceding-token ngrams: tuberin is atIe1: trigger-arg-path: Negative_activation >nsubj [lemma='akt'] controllertVe1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='tuberin'] controlledt4interceding-token ngrams: physiological substrate oftce1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='akt'] controllertce2: trigger-arg-path: phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controllert(interceding-token ngrams: promoting CDK2t4interceding-token ngrams: and cellular proliferationt+interceding-token ngrams: CDK2 activity andt"interceding-token ngrams: KIP1 ) ,tTe1: trigger-arg-path: inhibited >nsubj [lemma='akt'] controller:Gene_or_gene_productt!interceding-token ngrams: Akt andt interceding-token ngrams: of AkttLe1: trigger-arg-path: inhibited >dobj [lemma='tuberin'] Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='tuberin'] controlled:Gene_or_gene_productt%interceding-token ngrams: ) , therebytxe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='akt'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controller:Gene_or_gene_productt"interceding-token ngrams: ( KIP1 )t8interceding-token ngrams: direct physiological substratetme2: trigger-arg-path: phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] Gene_or_gene_productt"interceding-token ngrams: of p27 (t/interceding-token ngrams: activity and cellulart?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controller:Gene_or_gene_producttge2: trigger-arg-path: Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controllert0interceding-token ngrams: a direct physiologicalt$interceding-token ngrams: p27 ( KIP1tDe1: trigger-arg-path: inhibited:Negative_activation >dobj controlledt+interceding-token ngrams: results confirmedt.interceding-token ngrams: direct physiologicalt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controller:Gene_or_gene_producttue2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controllert,interceding-token ngrams: degradation of p27t`e1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='tuberin'] Gene_or_gene_productt]e1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='akt'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='akt'] controllert1interceding-token ngrams: mediated degradation oft:e1: trigger-arg-path: inhibited >dobj Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controllert*interceding-token ngrams: substrate of AkttAe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also inhibitedtEe1: trigger-arg-path: inhibited >dobj controlled:Gene_or_gene_producttinterceding-token ngrams: KIP1tme1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >nsubj [lemma='akt'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='tuberin'] controlledt$CSSPATH: ROOT  ++ ROOT >ccomp >nsubjt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] Gene_or_gene_productt/interceding-token ngrams: proliferation . Theset0interceding-token ngrams: results confirmed thattxe2: trigger-arg-path: phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controller:Gene_or_gene_productt$interceding-token ngrams: of Akt andtVe1: trigger-arg-path: Negative_activation >dobj [lemma='tuberin'] Gene_or_gene_producttwe2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controllerthe1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='akt'] controller:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='akt'] Gene_or_gene_productt interceding-token ngrams: ( KIP1t interceding-token ngrams: of p27tWe1: trigger-arg-path: inhibited >dobj [lemma='tuberin'] controlled:Gene_or_gene_productt0interceding-token ngrams: cellular proliferationt?e1: trigger-arg-path: inhibited >nsubj [lemma='akt'] controllert^e1: trigger-arg-path: Negative_activation >nsubj [lemma='akt'] controller:Gene_or_gene_productt$interceding-token ngrams: tuberin istke1: trigger-arg-path: inhibited:Negative_activation >dobj [lemma='tuberin'] controlled:Gene_or_gene_productt{e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='tuberin'] controlled:Gene_or_gene_producttIe1: trigger-arg-path: inhibited >nsubj [lemma='akt'] Gene_or_gene_productt|e2: trigger-arg-path: Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] controller:Gene_or_gene_productt interceding-token ngrams: KIP1 )t2interceding-token ngrams: cellular proliferation .t0interceding-token ngrams: thereby promoting CDK2t!interceding-token ngrams: tuberintde1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='akt'] controller:Gene_or_gene_productt0interceding-token ngrams: confirmed that tuberintNe1: trigger-arg-path: inhibited:Negative_activation >dobj Gene_or_gene_productt\e1: trigger-arg-path: lemmatizedTrigger=inhibit >dobj [lemma='tuberin'] Gene_or_gene_productt&interceding-token ngrams: substrate oft?e2: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] Gene_or_gene_productt1interceding-token ngrams: promoting CDK2 activityt1interceding-token ngrams: These results confirmedt&interceding-token ngrams: that tuberintfe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='tuberin'] controlledtLe1: trigger-arg-path: Negative_activation >dobj [lemma='tuberin'] controlledtinterceding-token ngrams: p27 (tBe1: trigger-arg-path: inhibited >dobj [lemma='tuberin'] controlledt)interceding-token ngrams: that tuberin istSe1: trigger-arg-path: Negative_activation >nsubj [lemma='akt'] Gene_or_gene_producttYe1: trigger-arg-path: inhibited:Negative_activation >dobj controlled:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='tuberin'] >prep_by [lemma='pi3k'] Gene_or_gene_producttae1: trigger-arg-path: Negative_activation >dobj [lemma='tuberin'] controlled:Gene_or_gene_producttSe1: trigger-arg-path: inhibited:Negative_activation >nsubj [lemma='akt'] controllert?interceding-tokens-full-span: mediated degradation of p27 ( KIP1 ) , thereby promoting CDK2 activity and cellular proliferation . These results confirmed that tuberin is a direct physiological substrate of Akt and thatt'interceding-token ngrams: CDK2 activityt1interceding-token ngrams: physiological substratet(interceding-token ngrams: confirmed thattpe1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_activation >dobj [lemma='tuberin'] Gene_or_gene_productt&interceding-token ngrams: Akt and thatt%interceding-token ngrams: Ras bindingt#interceding-token ngrams: to p110 [t"interceding-token ngrams: p110 [ -tinterceding-token ngrams: p110t interceding-token ngrams: p110 [t(interceding-token ngrams: Ras binding totVinterceding-tokens-full-span: and is directly activated by Ras binding to p110 [ - ] .t)interceding-token ngrams: binding to p110t(interceding-token ngrams: by Ras bindingt!interceding-token ngrams: to p110t*interceding-token ngrams: activated by Rast@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT activation byte2: trigger: stimulatetpe2: trigger-arg-path: Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='domain'] >prep_of [lemma='corest'] controller:Gene_or_gene_productt#e1: args2Role-mention-ngram: , eacht>e2: trigger-arg-path: stimulate >dobj >nn Gene_or_gene_productt\e2: trigger-arg-path: stimulate >nsubj [lemma='domain'] >prep_of [lemma='corest'] controllertue2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt!interceding-token ngrams: of NuRDt*e1: ents2Label-mention-ngram: and CoREST ,t6e1: trigger-arg-path: bind >dobj [lemma='hdac1'] themet&interceding-token ngrams: SANT domainstze2: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] Gene_or_gene_productt$interceding-token ngrams: domains oft/CSSPATH: ROOT >ccomp >prep_with >rcmod ++ ROOT t}e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] controlledt+e1: ents2Label-mention-ngram: of which bindt?e2: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] controller:Gene_or_gene_productt/interceding-token ngrams: repress transcriptiont]e1: trigger-arg-path: lemmatizedTrigger=bind nsubj >prep_of controller:Gene_or_gene_productt&e2: args2Role-mention-ngram: stimulatetSe1: trigger-arg-path: bind:Binding e1: trigger-arg-path: bind:Binding >dobj [lemma='hdac1'] themet interceding-token ngrams: NuRD ,t$interceding-token ngrams: , the SANTtOe2: trigger-arg-path: stimulate >nsubj >prep_of controller:Gene_or_gene_productt/e1: ents2Label-mention-ngram: which bind SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] Gene_or_gene_productt*interceding-token ngrams: the SANT domainstee1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='hdac1'] theme:Gene_or_gene_productt&e1: ents2Label-mention-ngram: of whicht>e1: trigger-arg-path: bind:Binding dobj [lemma='activity'] >nn [lemma='hdac1'] controlled:Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='domain'] >prep_of [lemma='corest'] controllertDe2: trigger-arg-path: stimulate >nsubj >prep_of Gene_or_gene_producttHe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] themetxinterceding-tokens-full-span: and HDAC2 to repress transcription . Like the MTA components of NuRD , the SANT domains oft*e1: args2Role-mention-ngram: CoREST , eacht?e2: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] controlled:Gene_or_gene_productt.interceding-token ngrams: transcription . LiketSe1: trigger-arg-path: bind:Binding >dobj [lemma='hdac1'] theme:Gene_or_gene_productt:e2: trigger-arg-path: stimulate >nsubj >prep_of controllert"interceding-token ngrams: HDAC2 totWe2: trigger-arg-path: stimulate >dobj [lemma='activity'] >nn [lemma='hdac1'] controlledt!interceding-token ngrams: the MTAtXe2: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of Gene_or_gene_producttHe1: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='hdac1'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] controlled:Gene_or_gene_producttMe1: trigger-arg-path: bind:Binding >dobj [lemma='hdac1'] Gene_or_gene_producttve2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] controlled:Gene_or_gene_productt&interceding-token ngrams: and HDAC2 tot*e1: args2Role-mention-ngram: each of whichtpe2: trigger-arg-path: stimulate:Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] controllert]e2: trigger-arg-path: stimulate:Positive_activation >dobj >nn controlled:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >dobj [lemma='hdac1'] themet2interceding-token ngrams: to repress transcriptiont"interceding-token ngrams: the SANTtNe1: trigger-arg-path: Binding dobj >nn controlledt1interceding-token ngrams: repress transcription .t>e1: trigger-arg-path: bind:Binding dobj [lemma='hdac1'] Gene_or_gene_productt"interceding-token ngrams: Like thet&e1: args2Role-mention-ngram: , each oftWe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] Gene_or_gene_producttnsubj [lemma='domain'] >prep_of [lemma='corest'] controllertHe1: trigger-arg-path: lemmatizedTrigger=bind nsubj [lemma='domain'] >prep_of [lemma='corest'] controller:Gene_or_gene_productt*e1: args2Role-mention-ngram: of which bindtue2: trigger-arg-path: stimulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] Gene_or_gene_producttdobj [lemma='activity'] >nn [lemma='hdac1'] Gene_or_gene_productt*interceding-token ngrams: HDAC2 to represst_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding dobj [lemma='hdac1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of controllert9e1: trigger-arg-path: Binding dobj [lemma='activity'] >nn [lemma='hdac1'] controlledt1e2: args2Role-mention-ngram: CONTROLLER stimulatetLe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >prep_of controllertRe2: trigger-arg-path: stimulate:Positive_activation >dobj >nn Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj >prep_of Gene_or_gene_producttMe1: trigger-arg-path: bind:Binding dobj [lemma='hdac1'] themetinterceding-token ngrams: HDAC2tinterceding-token ngrams: MTAtNe2: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of controllertfe2: trigger-arg-path: stimulate >nsubj [lemma='domain'] >prep_of [lemma='corest'] Gene_or_gene_producttKe1: trigger-arg-path: bind >dobj [lemma='hdac1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] controller:Gene_or_gene_productt+interceding-token ngrams: MTA components oftEe1: trigger-arg-path: bind dobj [lemma='activity'] >nn [lemma='hdac1'] Gene_or_gene_productt$interceding-token ngrams: to represst?e2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] Gene_or_gene_productt{e2: trigger-arg-path: Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] controller:Gene_or_gene_producttae2: trigger-arg-path: Positive_activation >dobj [lemma='activity'] >nn [lemma='hdac1'] controlledtfe2: trigger-arg-path: Positive_activation >nsubj [lemma='domain'] >prep_of [lemma='corest'] controllert+e1: ents2Label-mention-ngram: CoREST , eacht$e1: ents2Label-mention-ngram: , eachtHe2: trigger-arg-path: stimulate:Positive_activation >dobj >nn controlledtje2: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_activation >nsubj >prep_of Gene_or_gene_productt interceding-token ngrams: . Liketce2: trigger-arg-path: stimulate:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt'e1: trigger-arg-path: bind dobj [lemma='activity'] >nn [lemma='hdac1'] Gene_or_gene_productt#e1: args2Role-mention-ngram: CoRESTt)e1: args2Role-mention-ngram: and CoREST ,tWe1: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='hdac1'] Gene_or_gene_productt-e1: args2Role-mention-ngram: which bind THEMEtxe2: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='domain'] >prep_of [lemma='corest'] Gene_or_gene_productt-e1: args2Role-mention-ngram: THEME and CoRESTtPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding dobj [lemma='activity'] >nn [lemma='hdac1'] controlled:Gene_or_gene_productt'e1: args2Role-mention-ngram: and CoRESTtinterceding-token ngrams: SANTt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='hdac1'] Gene_or_gene_productt$interceding-token ngrams: NuRD , thet.e2: ents2Label-mention-ngram: stimulate SHAREDt%e1: ents2Label-mention-ngram: each oft$e1: args2Role-mention-ngram: each oft(e1: ents2Label-mention-ngram: and CoRESTt'e2: ents2Label-mention-ngram: stimulatet1e2: args2Role-mention-ngram: stimulate CONTROLLEDtIe2: trigger-arg-path: stimulate >dobj >nn controlled:Gene_or_gene_productt/e2: ents2Label-mention-ngram: SHARED and CoRESTt%e2: args2Role-mention-ngram: of whichtmtrigger-to-trigger-path: e1:interacts:Binding >prep_with [lemma='sin3'] >rcmod [lemma='bind'] e2:bind:BindingtHe2: trigger-arg-path: Binding prep_with [lemma='sin3'] theme:Gene_or_gene_productt%e2: args2Role-mention-ngram: CoREST ,tXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='sin3'] themetTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rest'] themetNe1: trigger-arg-path: interacts >prep_with [lemma='sin3'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding prep_with [lemma='sin3'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: and CoREST ,tOtrigger-to-trigger-path: e1:interacts:Binding >prep_with >rcmod e2:bind:BindingtNe1: trigger-arg-path: Binding >nsubj [lemma='rest'] theme:Gene_or_gene_producttHe2: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='hdac1'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: of whicht$e2: args2Role-mention-ngram: each oft&e2: ents2Label-mention-ngram: CoREST ,t*e2: args2Role-mention-ngram: CoREST , eacht]e2: trigger-arg-path: lemmatizedTrigger=bind prep_with [lemma='sin3'] theme:Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rest'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind dobj [lemma='hdac1'] themet>e2: trigger-arg-path: bind:Binding >dobj [lemma='hdac1'] themet*e2: args2Role-mention-ngram: each of whichtie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rest'] theme:Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='sin3'] Gene_or_gene_producttBshortest-path: prep_with [lemma='sin3']t+e2: ents2Label-mention-ngram: CoREST , eachtae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rest'] theme:Gene_or_gene_productt&e2: args2Role-mention-ngram: , each oftXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rest'] theme:Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='rest'] Gene_or_gene_productt(e2: ents2Label-mention-ngram: and CoRESTt;e1: trigger-arg-path: interacts >nsubj [lemma='rest'] themet?e1: trigger-arg-path: interacts >prep_with [lemma='sin3'] themetee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sin3'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding dobj [lemma='hdac1'] themet)e2: args2Role-mention-ngram: and CoREST ,t_e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='hdac1'] Gene_or_gene_productt'e2: args2Role-mention-ngram: and CoRESTt9e2: trigger-arg-path: Binding >dobj [lemma='hdac1'] themet*e2: args2Role-mention-ngram: of which bindt+e2: ents2Label-mention-ngram: each of whichtHe2: trigger-arg-path: Binding >dobj [lemma='hdac1'] Gene_or_gene_producttSe2: trigger-arg-path: bind:Binding e2: trigger-arg-path: bind:Binding prep_with [lemma='sin3'] theme:Gene_or_gene_producttCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rest'] themetHe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] themetEe2: trigger-arg-path: bind >dobj [lemma='hdac1'] Gene_or_gene_productt=e1: trigger-arg-path: Binding >prep_with [lemma='sin3'] themetee2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='hdac1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: Binding >dobj [lemma='hdac1'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: of which bindtce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='rest'] Gene_or_gene_producttMe2: trigger-arg-path: bind:Binding prep_with [lemma='sin3'] themetRe1: trigger-arg-path: Binding >prep_with [lemma='sin3'] theme:Gene_or_gene_producttKe2: trigger-arg-path: bind >dobj [lemma='hdac1'] theme:Gene_or_gene_productt9e2: trigger-arg-path: Binding nsubj [lemma='rest'] themetSe2: trigger-arg-path: bind:Binding >dobj [lemma='hdac1'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: CoRESTtPe1: trigger-arg-path: interacts >nsubj [lemma='rest'] theme:Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sin3'] themet_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='sin3'] Gene_or_gene_producttHe1: trigger-arg-path: Binding >nsubj [lemma='rest'] Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='rest'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='hdac1'] Gene_or_gene_producttVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='sin3'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='rest'] themetme1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ebus'] theme:Gene_or_gene_producttIe2: trigger-arg-path: binds >prep_to [lemma='hdac3'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hdac3'] Gene_or_gene_producttntrigger-to-trigger-path: e1:interacts:Binding >prep_with [lemma='ebus'] >rcmod [lemma='bind'] e2:binds:Bindingt$shortest-path: prep_with >nntTe2: trigger-arg-path: binds nn [lemma='beta-propeller'] themetke2: trigger-arg-path: Binding nn [lemma='beta-propeller'] theme:Gene_or_gene_productt#e2: args2Role-mention-ngram: TBL1 ,tte2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='beta-propeller'] Gene_or_gene_producttXe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ebus'] themetZe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hdac3'] Gene_or_gene_producttNe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smrter'] themetVe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ebus'] Gene_or_gene_producttLe1: trigger-arg-path: Binding >prep_with [lemma='ebus'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hdac3'] themet:e2: trigger-arg-path: binds >prep_to [lemma='hdac3'] themet)e2: args2Role-mention-ngram: TBL1 , whichtze2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='beta-propeller'] theme:Gene_or_gene_producttEe1: trigger-arg-path: interacts:Binding >nsubj [lemma='smrter'] themet\e1: trigger-arg-path: interacts:Binding >prep_with [lemma='ebus'] theme:Gene_or_gene_productt!e2: args2Role-mention-ngram: TBL1t|e2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='beta-propeller'] Gene_or_gene_producttPtrigger-to-trigger-path: e1:interacts:Binding >prep_with >rcmod e2:binds:BindingtNe1: trigger-arg-path: interacts >prep_with [lemma='ebus'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smrter'] theme:Gene_or_gene_productt_shortest-path: prep_with [lemma='ebus'] >nn [lemma='beta-propeller']tVe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smrter'] themetme2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='beta-propeller'] themetge1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='ebus'] Gene_or_gene_producttke2: trigger-arg-path: binds:Binding nn [lemma='beta-propeller'] Gene_or_gene_producttQe2: trigger-arg-path: binds:Binding >prep_to [lemma='hdac3'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='smrter'] Gene_or_gene_producttLe1: trigger-arg-path: interacts >nsubj [lemma='smrter'] Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ebus'] theme:Gene_or_gene_productt-e2: ents2Label-mention-ngram: SHARED and TBL1t\e2: trigger-arg-path: binds:Binding nn [lemma='beta-propeller'] themetRe1: trigger-arg-path: interacts >nsubj [lemma='smrter'] theme:Gene_or_gene_producttVe2: trigger-arg-path: Binding nn [lemma='beta-propeller'] themetBe2: trigger-arg-path: binds:Binding >prep_to [lemma='hdac3'] themet=e1: trigger-arg-path: interacts >nsubj [lemma='smrter'] themet?e1: trigger-arg-path: interacts >prep_with [lemma='ebus'] themetprep_to [lemma='hdac3'] themetSe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hdac3'] themetOe2: trigger-arg-path: binds >prep_to [lemma='hdac3'] theme:Gene_or_gene_producttPe1: trigger-arg-path: Binding >nsubj [lemma='smrter'] theme:Gene_or_gene_producttTe1: trigger-arg-path: interacts >prep_with [lemma='ebus'] theme:Gene_or_gene_producttZe1: trigger-arg-path: interacts:Binding >nsubj [lemma='smrter'] theme:Gene_or_gene_producttce2: trigger-arg-path: binds nn [lemma='beta-propeller'] Gene_or_gene_producttie2: trigger-arg-path: binds nn [lemma='beta-propeller'] theme:Gene_or_gene_producttee2: trigger-arg-path: Binding nn [lemma='beta-propeller'] Gene_or_gene_productt%e2: args2Role-mention-ngram: and TBL1tke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smrter'] theme:Gene_or_gene_productt(e2: ents2Label-mention-ngram: and TBL1 ,tTe1: trigger-arg-path: interacts:Binding >nsubj [lemma='smrter'] Gene_or_gene_productt;e1: trigger-arg-path: Binding >nsubj [lemma='smrter'] themetee1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='smrter'] Gene_or_gene_productt"e2: ents2Label-mention-ngram: TBL1tRe1: trigger-arg-path: Binding >prep_with [lemma='ebus'] theme:Gene_or_gene_productt'e2: args2Role-mention-ngram: and TBL1 ,tee2: trigger-arg-path: lemmatizedTrigger=bind nn [lemma='beta-propeller'] themethe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='hdac3'] theme:Gene_or_gene_productt$e2: ents2Label-mention-ngram: TBL1 ,t+e2: args2Role-mention-ngram: THEME and TBL1tGe1: trigger-arg-path: interacts:Binding >prep_with [lemma='ebus'] themet?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding nn [lemma='beta-propeller'] theme:Gene_or_gene_producttQe2: trigger-arg-path: Binding >prep_to [lemma='hdac3'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >prep_to [lemma='hdac3'] Gene_or_gene_productt&e2: ents2Label-mention-ngram: and TBL1t_e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ebus'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='ebus'] themetqe2: trigger-arg-path: binds:Binding nn [lemma='beta-propeller'] theme:Gene_or_gene_producttWe2: trigger-arg-path: binds:Binding >prep_to [lemma='hdac3'] theme:Gene_or_gene_productt*e2: ents2Label-mention-ngram: TBL1 , whicht=e1: trigger-arg-path: Binding >prep_with [lemma='ebus'] themetJe1: trigger-arg-path: Binding >nsubj [lemma='smrter'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='hdac3'] theme:Gene_or_gene_producttinterceding-token ngrams: Snailt(interceding-token ngrams: mesoderm . Thet0interceding-token ngrams: the embryonic mesodermt/interceding-token ngrams: their transcriptionalt"interceding-token ngrams: mesodermt$interceding-token ngrams: and TBL1 ,t"interceding-token ngrams: to theirt#interceding-token ngrams: HDAC3 andt:interceding-token ngrams: deacetylates histones associatedt.interceding-token ngrams: embryonic mesoderm .t'interceding-token ngrams: the embryonictMe2: trigger-arg-path: complex:Binding >nn [lemma='ebus'] Gene_or_gene_productt&interceding-token ngrams: to HDAC3 andtYe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smrter'] Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ebus'] theme:Gene_or_gene_productt$interceding-token ngrams: mesoderm .t4interceding-token ngrams: transcriptional repressiont:interceding-token ngrams: their transcriptional repressiont?interceding-tokens-full-span: and TBL1 , which binds to HDAC3 and deacetylates histones associated with Snail target genes , leading to their transcriptional repression in the embryonic mesoderm . ThetUe2: trigger-arg-path: complex:Binding >nn [lemma='smrter'] theme:Gene_or_gene_productt interceding-token ngrams: TBL1 ,t2interceding-token ngrams: to their transcriptionalt(interceding-token ngrams: binds to HDAC3t,interceding-token ngrams: embryonic mesodermt%interceding-token ngrams: which bindst'interceding-token ngrams: repression int+interceding-token ngrams: with Snail targettRe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smrter'] themet*interceding-token ngrams: and deacetylatestinterceding-token ngrams: TBL1t"interceding-token ngrams: and TBL1t"interceding-token ngrams: histonestGe2: trigger-arg-path: Binding >nn [lemma='smrter'] Gene_or_gene_productt$interceding-token ngrams: with SnailtHe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ebus'] themet6e2: trigger-arg-path: Binding >nn [lemma='ebus'] themetMe2: trigger-arg-path: complex >nn [lemma='smrter'] theme:Gene_or_gene_producttEe2: trigger-arg-path: complex >nn [lemma='ebus'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ebus'] Gene_or_gene_producttOe2: trigger-arg-path: complex:Binding >nn [lemma='smrter'] Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ebus'] Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smrter'] Gene_or_gene_productt@e2: trigger-arg-path: complex:Binding >nn [lemma='smrter'] themetJe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smrter'] themet+interceding-token ngrams: repression in thetSe2: trigger-arg-path: complex:Binding >nn [lemma='ebus'] theme:Gene_or_gene_productt*interceding-token ngrams: leading to theirt&interceding-token ngrams: Snail targett>e2: trigger-arg-path: complex:Binding >nn [lemma='ebus'] themet,interceding-token ngrams: Snail target genestee2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ebus'] theme:Gene_or_gene_productt&interceding-token ngrams: deacetylatest)interceding-token ngrams: genes , leadingtMe2: trigger-arg-path: Binding >nn [lemma='smrter'] theme:Gene_or_gene_producttKe2: trigger-arg-path: complex >nn [lemma='ebus'] theme:Gene_or_gene_productt3interceding-token ngrams: and deacetylates histonest-interceding-token ngrams: histones associatedt0interceding-token ngrams: HDAC3 and deacetylatest'interceding-token ngrams: , which bindstge2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='smrter'] theme:Gene_or_gene_productt/interceding-token ngrams: deacetylates histonest7interceding-token ngrams: transcriptional repression int(interceding-token ngrams: which binds tot#interceding-token ngrams: embryonict2interceding-token ngrams: histones associated witht/interceding-token ngrams: associated with Snailt&interceding-token ngrams: TBL1 , whicht8e2: trigger-arg-path: complex >nn [lemma='smrter'] themet*interceding-token ngrams: in the embryonict8e2: trigger-arg-path: Binding >nn [lemma='smrter'] themet6e2: trigger-arg-path: complex >nn [lemma='ebus'] themet"interceding-token ngrams: to HDAC3tEe2: trigger-arg-path: Binding >nn [lemma='ebus'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ebus'] themetGe2: trigger-arg-path: complex >nn [lemma='smrter'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='smrter'] theme:Gene_or_gene_producttKe2: trigger-arg-path: Binding >nn [lemma='ebus'] theme:Gene_or_gene_productt(interceding-token ngrams: PI3K , whereast.interceding-token ngrams: bind preferably PI3Kt>interceding-tokens-full-span: , bind preferably PI3K , whereast$interceding-token ngrams: preferablyt interceding-token ngrams: PI3K ,t?trigger-to-trigger-path: e1:phosphorylated:Positive_regulation advcl [lemma='weak'] >nsubj [lemma='binding'] e2:binding:Bindingt)interceding-token ngrams: preferably PI3Kt interceding-token ngrams: , bindt+interceding-token ngrams: , bind preferablytmtrigger-to-trigger-path: e1:phosphorylated:Positive_regulation advcl >nsubj e2:binding:Bindingt+interceding-token ngrams: preferably PI3K ,t)interceding-token ngrams: bind preferablyt)CSSPATH: ROOT >ccomp ++ ROOT >dobj >appost1interceding-token ngrams: competitive recruitmentt&interceding-token ngrams: To test thist)interceding-token ngrams: the competitivetMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] themet5interceding-token ngrams: the competitive recruitmentt+interceding-token ngrams: this prediction ,t;e2: trigger-arg-path: binding >prep_of [lemma='shp2'] themet\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] Gene_or_gene_productt/interceding-token ngrams: by phosphorylated IRSt#interceding-token ngrams: . To testtPe2: trigger-arg-path: binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt$interceding-token ngrams: of PI3K byt$interceding-token ngrams: predictiont,interceding-token ngrams: phosphorylated IRSt.interceding-token ngrams: test this predictiont#interceding-token ngrams: test thist+interceding-token ngrams: by phosphorylatedt.interceding-token ngrams: phosphorylated IRS .tJe2: trigger-arg-path: binding >prep_of [lemma='shp2'] Gene_or_gene_productt{interceding-tokens-full-span: and the competitive recruitment of PI3K by phosphorylated IRS . To test this prediction , thet;e2: trigger-arg-path: Binding >prep_of [lemma='shp2'] themet4interceding-token ngrams: competitive recruitment oftbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt0interceding-token ngrams: PI3K by phosphorylatedt"interceding-token ngrams: IRS . Totde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] Gene_or_gene_productt-interceding-token ngrams: and the competitivetXe2: trigger-arg-path: binding:Binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt&interceding-token ngrams: prediction ,t*interceding-token ngrams: prediction , thetPe2: trigger-arg-path: Binding >prep_of [lemma='shp2'] theme:Gene_or_gene_productt!interceding-token ngrams: To testtinterceding-token ngrams: IRS .tJe2: trigger-arg-path: Binding >prep_of [lemma='shp2'] Gene_or_gene_producttinterceding-token ngrams: testt!interceding-token ngrams: PI3K byt)interceding-token ngrams: this predictiontCe2: trigger-arg-path: binding:Binding >prep_of [lemma='shp2'] themetje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='shp2'] themet-interceding-token ngrams: recruitment of PI3KtRe2: trigger-arg-path: binding:Binding >prep_of [lemma='shp2'] Gene_or_gene_producttie2: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttoe1: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetqe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetge1: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttoe2: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj theme:Gene_or_gene_producttSe1: trigger-arg-path: Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetme1: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttqe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetge2: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_productt`e1: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttQe2: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themet>e2: trigger-arg-path: bound >ccomp >nsubj Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetfe2: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttue1: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_productt`e1: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetFe2: trigger-arg-path: Binding >ccomp >nsubj theme:Gene_or_gene_producttYe2: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetne1: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttYe1: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetye2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttOe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp >nsubj Gene_or_gene_producttbe1: trigger-arg-path: Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_productt`e2: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttXe1: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetXe2: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themethe2: trigger-arg-path: Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttbe2: trigger-arg-path: Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttue2: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_productthe2: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttEshortest-path: ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetwe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttQe1: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetye1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttoe1: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_productthe1: trigger-arg-path: Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttoe2: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttFe2: trigger-arg-path: bound:Binding >ccomp >nsubj Gene_or_gene_producttDe2: trigger-arg-path: bound >ccomp >nsubj theme:Gene_or_gene_producttfe1: trigger-arg-path: bound >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttZe2: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themet@e2: trigger-arg-path: Binding >ccomp >nsubj Gene_or_gene_producttLe2: trigger-arg-path: bound:Binding >ccomp >nsubj theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetqe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themetWe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj Gene_or_gene_productt`e2: trigger-arg-path: bound:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetie1: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttme2: trigger-arg-path: bound >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productthe1: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] Gene_or_gene_producttbe1: trigger-arg-path: lemmatizedTrigger=bind >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] themet~e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp >nsubj theme:Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttZe1: trigger-arg-path: Binding >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetie1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] themetne2: trigger-arg-path: bound:Binding >ccomp [lemma='decrease'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='concentration'] >prep_of [lemma='gab1'] theme:Gene_or_gene_productt#interceding-token ngrams: scale ( ,t+interceding-token ngrams: EGF stimulation )t interceding-token ngrams: dashedt%interceding-token ngrams: whereas thet?e1: trigger-arg-path: bound:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] Gene_or_gene_productt-interceding-token ngrams: dashed lines versustinterceding-token ngrams: SHP2t&interceding-token ngrams: time scale (t#interceding-token ngrams: ) only ont(interceding-token ngrams: dotted lines )t)interceding-token ngrams: GAB1 bound SHP2t0e1: trigger-arg-path: bound:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt"interceding-token ngrams: ( , bluetYe1: trigger-arg-path: bound:Binding >ccomp [lemma='increase'] >nsubj [lemma='pi3k'] themet interceding-token ngrams: dottedt#interceding-token ngrams: lines ) ,tNe1: trigger-arg-path: bound:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] Gene_or_gene_producttTe1: trigger-arg-path: bound:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] Gene_or_gene_productt1interceding-token ngrams: post-peak concentrationtinterceding-token ngrams: scalet9e1: trigger-arg-path: Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] themet'interceding-token ngrams: stimulation )t=e1: trigger-arg-path: bound ccomp [lemma='increase'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt'interceding-token ngrams: concentrationt!interceding-token ngrams: lines )t,interceding-token ngrams: PI3K will decreaset/interceding-token ngrams: GAB1 phosphotyrosinest]e1: trigger-arg-path: lemmatizedTrigger=bind ccomp [lemma='increase'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt2interceding-token ngrams: phosphotyrosines by GAB1t,interceding-token ngrams: stimulation ) onlythe1: trigger-arg-path: Binding >ccomp [lemma='increase'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_productt'interceding-token ngrams: will decreaset,interceding-token ngrams: lines versus greent/interceding-token ngrams: whereas the post-peakt)interceding-token ngrams: GAB1 bound PI3KtGCSSPATH: ROOT >ccomp >nsubj >appos >prep_of >rcmod ++ ROOT >dobj >appost"interceding-token ngrams: SHP2 andt+interceding-token ngrams: compared with EGFt-interceding-token ngrams: versus green dottedtEe1: trigger-arg-path: bound:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] Gene_or_gene_productt&interceding-token ngrams: green dottedt interceding-token ngrams: , bluet'interceding-token ngrams: by GAB1 boundt"interceding-token ngrams: owing tot_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] themete1: trigger-arg-path: lemmatizedTrigger=bind:Binding >ccomp [lemma='increase'] >nsubj [lemma='pi3k'] theme:Gene_or_gene_producttNe1: trigger-arg-path: Binding ccomp [lemma='increase'] >nsubj [lemma='pi3k'] themetinterceding-token ngrams: owingtbe1: trigger-arg-path: Binding >ccomp [lemma='increase'] >nsubj [lemma='pi3k'] Gene_or_gene_productt#interceding-token ngrams: PI3K willt'interceding-token ngrams: the post-peakt$interceding-token ngrams: ( comparedt7e1: trigger-arg-path: bound ccomp [lemma='increase'] >nsubj [lemma='pi3k'] themet?interceding-tokens-full-span: will increase ( compared with EGF stimulation ) only on a short time scale ( , blue dashed lines versus green dotted lines ) , whereas the post-peak concentration of GAB1 bound PI3K will decrease owing to dephosphorylation of GAB1 phosphotyrosines by GAB1 bound SHP2 and the competitive recruitment of PI3K by phosphorylated IRS . To test this prediction , thet$interceding-token ngrams: increase (t(interceding-token ngrams: decrease owingtWe1: trigger-arg-path: lemmatizedTrigger=bind ccomp >nsubj >dep ++ ROOT >dobj >appost?interceding-tokens-full-span: will decrease owing to dephosphorylation of GAB1 phosphotyrosines by GAB1 bound SHP2 and the competitive recruitment of PI3K by phosphorylated IRS . To test this prediction , thetde2: trigger-arg-path: increased >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controllertKe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT co-stimulation increasedt+e2: args2Role-mention-ngram: co-stimulationt,e2: ents2Label-mention-ngram: co-stimulationt5e2: args2Role-mention-ngram: increased the CONTROLLEDt?e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controller:Gene_or_gene_producttne2: trigger-arg-path: increased >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] Gene_or_gene_productt@e2: args2Role-mention-ngram: CONTROLLER co-stimulation increasedt?e2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controller:Gene_or_gene_producttxe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controllert?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controller:Gene_or_gene_productt?interceding-tokens-full-span: to GAB1 and of PI3K to IRS4 ( the major IRS protein in these cells was measured by immunoprecipitation analysis following stimulation of HEK293 cells with EGF , insulin and their combination . The data confirm thattye2: trigger-arg-path: increased >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controller:Gene_or_gene_productt?e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT co-stimulationt)CSSPATH: ROOT >dobj >appos ++ ROOT >ccompt2e2: ents2Label-mention-ngram: increased the SHAREDtxe2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] Gene_or_gene_producttne2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controllert6e2: ents2Label-mention-ngram: co-stimulation increasedt6e2: args2Role-mention-ngram: CONTROLLER co-stimulationt:e2: ents2Label-mention-ngram: co-stimulation increased thet5e2: args2Role-mention-ngram: co-stimulation increasedt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] Gene_or_gene_productte2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controllertue2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controllert9e2: args2Role-mention-ngram: co-stimulation increased thet?e2: trigger-arg-path: Positive_regulation >nsubj [lemma='co-stimulation'] >nn [lemma='insulin-egf'] controller:Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] theme:Generic_entitytQe1: trigger-arg-path: bind:Binding >dobj [lemma='p85'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='they'] themetdobj [lemma='p85'] themetLe2: trigger-arg-path: Binding >dobj [lemma='p85'] theme:Gene_or_gene_productt4e2: trigger-arg-path: bind >dobj [lemma='p85'] themet[e2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] theme:Gene_or_gene_producttCe1: trigger-arg-path: bind >dobj [lemma='p85'] Gene_or_gene_productt[e1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] theme:Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] Generic_entitytFe1: trigger-arg-path: Binding >dobj [lemma='p85'] Gene_or_gene_productt-e2: args2Role-mention-ngram: THEME bind THEMEtNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] themetdobj [lemma='p85'] themetFe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] themetMe1: trigger-arg-path: bind:Binding >nsubj [lemma='they'] theme:Generic_entityt?e1: trigger-arg-path: bind >nsubj [lemma='they'] Generic_entitytIe2: trigger-arg-path: bind >dobj [lemma='p85'] theme:Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] Gene_or_gene_producttPe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='they'] themetNe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] themet0e1: ents2Label-mention-ngram: SHARED bind SHAREDtLe1: trigger-arg-path: Binding >dobj [lemma='p85'] theme:Gene_or_gene_producttEe1: trigger-arg-path: bind >nsubj [lemma='they'] theme:Generic_entitytWe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] theme:Generic_entityt]e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] Gene_or_gene_producttCe2: trigger-arg-path: bind >dobj [lemma='p85'] Gene_or_gene_producttFe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] themetUe1: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] Generic_entitytce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] theme:Gene_or_gene_producttGe1: trigger-arg-path: bind:Binding >nsubj [lemma='they'] Generic_entityt0e2: ents2Label-mention-ngram: SHARED bind SHAREDtBe1: trigger-arg-path: Binding >nsubj [lemma='they'] Generic_entityt7e2: trigger-arg-path: Binding >dobj [lemma='p85'] themetIe1: trigger-arg-path: bind >dobj [lemma='p85'] theme:Gene_or_gene_productt-e1: args2Role-mention-ngram: THEME bind THEMEtKe1: trigger-arg-path: bind:Binding >dobj [lemma='p85'] Gene_or_gene_producttFe2: trigger-arg-path: Binding >dobj [lemma='p85'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind >dobj [lemma='p85'] Gene_or_gene_productt4e1: trigger-arg-path: bind >dobj [lemma='p85'] themetce2: trigger-arg-path: lemmatizedTrigger=bind:Binding >dobj [lemma='p85'] theme:Gene_or_gene_productt6e1: trigger-arg-path: bind >nsubj [lemma='they'] themetKe2: trigger-arg-path: bind:Binding >dobj [lemma='p85'] Gene_or_gene_producttQe2: trigger-arg-path: bind:Binding >dobj [lemma='p85'] theme:Gene_or_gene_productt7e1: trigger-arg-path: Binding >dobj [lemma='p85'] themet>e1: trigger-arg-path: bind:Binding >nsubj [lemma='they'] themetHe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='they'] themetHe1: trigger-arg-path: Binding >nsubj [lemma='they'] theme:Generic_entityt.e2: ents2Label-mention-ngram: residues , whicht2e2: ents2Label-mention-ngram: threonine residues ,t(e2: ents2Label-mention-ngram: and IRS ont4e2: ents2Label-mention-ngram: which disable tyrosinet+e2: ents2Label-mention-ngram: on serine andt$e2: ents2Label-mention-ngram: IRS ont.e2: ents2Label-mention-ngram: disable tyrosinet-e2: ents2Label-mention-ngram: , which disablet(e2: ents2Label-mention-ngram: residues ,t!e2: ents2Label-mention-ngram: IRSt%e2: ents2Label-mention-ngram: and IRStnsubj Gene_or_gene_producttge1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='hdac7'] controllert\e1: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] controlled:Sumoylationt\e1: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='sumoylation'] Sumoylationtinterceding-tokens-full-span: with Sumo-1 in a reconstituted system . More importantly , knockdown of HDAC7 abrogates basal andt,interceding-token ngrams: in a reconstitutedt,interceding-token ngrams: knockdown of HDAC7t1interceding-token ngrams: importantly , knockdownt3e2: ents2Label-mention-ngram: FAMILY induced SHAREDtle1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='sumoylation'] controlledt0e1: args2Role-mention-ngram: potently stimulatest)interceding-token ngrams: abrogates basalt;e1: trigger-arg-path: Positive_regulation >dobj Sumoylationt0e1: args2Role-mention-ngram: CONTROLLER potentlytde1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='sumoylation'] controlled:Sumoylationtbe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj controlled:Sumoylationt8e1: ents2Label-mention-ngram: potently stimulates SHAREDtKe1: trigger-arg-path: Positive_regulation >nsubj [lemma='hdac7'] controllert0interceding-token ngrams: reconstituted system .t-interceding-token ngrams: abrogates basal andt'interceding-token ngrams: reconstitutedt`e1: trigger-arg-path: Positive_regulation >nsubj [lemma='hdac7'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: potentlyt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT potentlytGe1: trigger-arg-path: stimulates >nsubj controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='sumoylation'] SumoylationtYe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='sumoylation'] Sumoylationt&e1: ents2Label-mention-ngram: potentlyt1e1: trigger-arg-path: stimulates >dobj controlledtHe1: trigger-arg-path: stimulates >dobj [lemma='sumoylation'] SumoylationtNe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj controlled:SumoylationtLe1: trigger-arg-path: stimulates >nsubj [lemma='hdac7'] Gene_or_gene_productthe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='hdac7'] controller:Gene_or_gene_producttFe1: trigger-arg-path: Positive_regulation >dobj controlled:Sumoylationt[e1: trigger-arg-path: stimulates:Positive_regulation >nsubj controller:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='hdac7'] controller:Gene_or_gene_productt"interceding-token ngrams: of HDAC7tFe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT potently stimulatestCe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj SumoylationtQe1: trigger-arg-path: stimulates:Positive_regulation >dobj controlled:Sumoylationt%interceding-token ngrams: , knockdownt0interceding-token ngrams: a reconstituted systemt)interceding-token ngrams: HDAC7 abrogatest interceding-token ngrams: Sumo-1txe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj [lemma='sumoylation'] controlled:SumoylationtSe1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='hdac7'] controllert.interceding-token ngrams: reconstituted systemtVe1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='hdac7'] controllertqe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >nsubj [lemma='hdac7'] Gene_or_gene_producttQe1: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] Sumoylationtge1: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='sumoylation'] controlled:SumoylationtFe1: trigger-arg-path: stimulates:Positive_regulation >dobj Sumoylationtke1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='hdac7'] controller:Gene_or_gene_productt/interceding-token ngrams: HDAC7 abrogates basalt`e1: trigger-arg-path: stimulates:Positive_regulation >nsubj [lemma='hdac7'] Gene_or_gene_productt#interceding-token ngrams: basal andt2e1: trigger-arg-path: stimulates >dobj SumoylationtPe1: trigger-arg-path: Positive_regulation >dobj [lemma='sumoylation'] controlledtSe1: trigger-arg-path: stimulates >dobj [lemma='sumoylation'] controlled:SumoylationtXe1: trigger-arg-path: lemmatizedTrigger=stimulate >dobj [lemma='sumoylation'] controlledt,interceding-token ngrams: of HDAC7 abrogatest=e1: trigger-arg-path: stimulates >dobj controlled:SumoylationtGe1: trigger-arg-path: stimulates >dobj [lemma='sumoylation'] controlledtUe1: trigger-arg-path: Positive_regulation >nsubj [lemma='hdac7'] Gene_or_gene_producttBe1: trigger-arg-path: stimulates >nsubj [lemma='hdac7'] controllert#interceding-token ngrams: Sumo-1 int[e1: trigger-arg-path: stimulates:Positive_regulation >dobj [lemma='sumoylation'] controlledt"interceding-token ngrams: system .t%interceding-token ngrams: with Sumo-1t(interceding-token ngrams: , knockdown oft'interceding-token ngrams: system . Moret;e1: args2Role-mention-ngram: CONTROLLER potently stimulatestWe1: trigger-arg-path: lemmatizedTrigger=stimulate:Positive_regulation >dobj SumoylationtEe1: trigger-arg-path: stimulates:Positive_regulation >dobj controlledt%interceding-token ngrams: Sumo-1 in at;e1: args2Role-mention-ngram: potently stimulates CONTROLLEDt(interceding-token ngrams: with Sumo-1 int)interceding-token ngrams: a reconstitutedtnsubj Gene_or_gene_productt;e1: ents2Label-mention-ngram: stimulates SHARED sumoylationt]e1: trigger-arg-path: lemmatizedTrigger=stimulate >nsubj [lemma='hdac7'] Gene_or_gene_producttinterceding-token ngrams: HDAC7t1e1: ents2Label-mention-ngram: potently stimulatestWe1: trigger-arg-path: stimulates >nsubj [lemma='hdac7'] controller:Gene_or_gene_producttVe2: trigger-arg-path: abrogates >ccomp [lemma='induce'] controlled:Positive_regulationt#e2: ents2Label-mention-ngram: basaltLe2: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] controlledt:e2: trigger-arg-path: abrogates >ccomp Positive_regulationtDe2: trigger-arg-path: abrogates >nsubj >prep_of Gene_or_gene_productthe2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllertre2: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllert?e2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_productt.e2: ents2Label-mention-ngram: basal and FAMILYthe2: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_productt}e2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttKe2: trigger-arg-path: abrogates >ccomp [lemma='induce'] Positive_regulationtge2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] controlledt'e2: ents2Label-mention-ngram: basal andtEe2: trigger-arg-path: abrogates:Positive_regulation >ccomp controlledt&e2: args2Role-mention-ngram: basal andtNe2: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of controllert|e2: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_productt1e2: trigger-arg-path: abrogates >ccomp controlledt1e2: ents2Label-mention-ngram: abrogates basal andt-e1: ents2Label-mention-ngram: SHARED potentlytre2: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of controller:Gene_or_gene_productt^e2: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllertYe2: trigger-arg-path: abrogates:Positive_regulation >ccomp controlled:Positive_regulationtUe2: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] Positive_regulationt1e2: args2Role-mention-ngram: CONTROLLER abrogatestNe2: trigger-arg-path: abrogates:Positive_regulation >ccomp Positive_regulationt?e2: trigger-arg-path: abrogates:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp controlled:Positive_regulationtKe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of controllertje2: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt8e1: ents2Label-mention-ngram: SHARED potently stimulatesteinterceding-tokens-full-span: with Sumo-1 in a reconstituted system . More importantly , knockdown oft1e2: args2Role-mention-ngram: basal and CONTROLLEDtKe2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp Positive_regulationtBe2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp controlledt4e2: ents2Label-mention-ngram: SHARED abrogates basalt.e2: ents2Label-mention-ngram: SHARED abrogatestUe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_producttce2: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt0e2: args2Role-mention-ngram: abrogates basal andt?e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] controlled:Positive_regulationt7e2: args2Role-mention-ngram: CONTROLLER abrogates basalt\e2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] Positive_regulationt'e2: ents2Label-mention-ngram: abrogatestVe2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp controlledtBe2: trigger-arg-path: abrogates >ccomp [lemma='induce'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllerte2: trigger: abrogatestOe2: trigger-arg-path: abrogates >nsubj >prep_of controller:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp Positive_regulationtVe2: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] controlledtie2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of Gene_or_gene_productt&e2: args2Role-mention-ngram: abrogatestSe2: trigger-arg-path: lemmatizedTrigger=abrogate >ccomp [lemma='induce'] controlledtje2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp controlled:Positive_regulationt-e2: ents2Label-mention-ngram: abrogates basaltXe2: trigger-arg-path: abrogates:Positive_regulation >nsubj >prep_of Gene_or_gene_productt`e2: trigger-arg-path: Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt_e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of controllert_e2: trigger-arg-path: abrogates:Positive_regulation >ccomp [lemma='induce'] Positive_regulationt{e2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] controlled:Positive_regulationt:e2: trigger-arg-path: abrogates >nsubj >prep_of controllert0e2: ents2Label-mention-ngram: and FAMILY inducedtse2: trigger-arg-path: abrogates >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controller:Gene_or_gene_productt,e2: args2Role-mention-ngram: abrogates basaltoe2: trigger-arg-path: lemmatizedTrigger=abrogate >nsubj [lemma='knockdown'] >prep_of [lemma='hdac7'] controllertpe2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >ccomp [lemma='induce'] Positive_regulationtte2: trigger-arg-path: lemmatizedTrigger=abrogate:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt"e2: args2Role-mention-ngram: basaltEe2: trigger-arg-path: abrogates >ccomp controlled:Positive_regulationtJe2: trigger-arg-path: lemmatizedTrigger=block advmod controllertSe2: trigger-arg-path: lemmatizedTrigger=block >dobj controlled:Gene_or_gene_producttfe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pml'] Gene_or_gene_producttUe2: trigger-arg-path: blocks:Negative_activation advmod controller:ComplextPe2: trigger-arg-path: blocks >dobj [lemma='pml'] controlled:Gene_or_gene_productt9e1: trigger-arg-path: interacts >nsubj [lemma='e7'] themet[e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod Complext.e2: args2Role-mention-ngram: blocks CONTROLLEDtje2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='pml'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pml'] themetYe2: trigger-arg-path: blocks:Negative_activation >dobj [lemma='pml'] Gene_or_gene_producttpe2: trigger-arg-path: blocks:Negative_activation advmod [lemma='directly'] ComplextWe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pml'] themetprep_with [lemma='pml'] themet+e2: ents2Label-mention-ngram: blocks SHAREDtUe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pml'] Gene_or_gene_producttxe2: trigger-arg-path: lemmatizedTrigger=block advmod [lemma='directly'] controller:ComplextLe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='pml'] controlledtfe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod controller:ComplextSe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='e7'] Familyt9e2: trigger-arg-path: blocks advmod controllertFe2: trigger-arg-path: Negative_activation advmod controllert7e2: trigger-arg-path: blocks >dobj Gene_or_gene_productte2: trigger: blockstYe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='e7'] theme:FamilytJe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='e7'] themet_e2: trigger-arg-path: blocks advmod [lemma='directly'] controllertle2: trigger-arg-path: Negative_activation advmod [lemma='directly'] controllertKe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='e7'] Familyt:e1: trigger-arg-path: interacts >nsubj [lemma='e7'] FamilytRe2: trigger-arg-path: Negative_activation >dobj [lemma='pml'] Gene_or_gene_producttKe2: trigger-arg-path: blocks:Negative_activation >dobj Gene_or_gene_producttOe2: trigger-arg-path: blocks:Negative_activation >dobj [lemma='pml'] controlledtQe1: trigger-arg-path: Binding >prep_with [lemma='pml'] theme:Gene_or_gene_producttBe2: trigger-arg-path: blocks >dobj controlled:Gene_or_gene_producttpe2: trigger-arg-path: lemmatizedTrigger=block advmod [lemma='directly'] controllertKe1: trigger-arg-path: Binding >prep_with [lemma='pml'] Gene_or_gene_producttMe2: trigger-arg-path: blocks:Negative_activation advmod controllertHe2: trigger-arg-path: lemmatizedTrigger=block >dobj Gene_or_gene_productt>e1: trigger-arg-path: Binding >nsubj [lemma='e7'] theme:Familyt(e2: ents2Label-mention-ngram: and blockst2e2: args2Role-mention-ngram: and blocks CONTROLLEDt[e1: trigger-arg-path: interacts:Binding >prep_with [lemma='pml'] theme:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='pml'] Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj controlled:Gene_or_gene_productt'e2: args2Role-mention-ngram: and blockstJe2: trigger-arg-path: blocks:Negative_activation advmod Complextue2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='pml'] controlled:Gene_or_gene_producttHe2: trigger-arg-path: Negative_activation >dobj [lemma='pml'] controlledtBe1: trigger-arg-path: interacts:Binding >nsubj [lemma='e7'] FamilytRe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='e7'] themet$e2: ents2Label-mention-ngram: blockst6e2: trigger-arg-path: blocks advmod Complextde2: trigger-arg-path: blocks:Negative_activation >dobj [lemma='pml'] controlled:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod controllertFe1: trigger-arg-path: interacts:Binding >prep_with [lemma='pml'] themet\e2: trigger-arg-path: blocks advmod [lemma='directly'] Complextle1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='pml'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod [lemma='directly'] ComplextEe2: trigger-arg-path: blocks >dobj [lemma='pml'] Gene_or_gene_producttVe2: trigger-arg-path: blocks:Negative_activation >dobj controlled:Gene_or_gene_producttAe2: trigger-arg-path: blocks advmod controller:Complextde1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pml'] theme:Gene_or_gene_producttte2: trigger-arg-path: Negative_activation advmod [lemma='directly'] controller:Complext`e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj [lemma='pml'] controlledtRe2: trigger-arg-path: lemmatizedTrigger=block advmod controller:ComplextAe1: trigger-arg-path: interacts:Binding >nsubj [lemma='e7'] themet>e1: trigger-arg-path: interacts >prep_with [lemma='pml'] themet@e1: trigger-arg-path: interacts >nsubj [lemma='e7'] theme:FamilytAe2: trigger-arg-path: blocks:Negative_activation >dobj controlledt{e2: trigger-arg-path: blocks:Negative_activation advmod [lemma='directly'] controller:ComplextSe1: trigger-arg-path: interacts >prep_with [lemma='pml'] theme:Gene_or_gene_productt/e2: ents2Label-mention-ngram: SHARED and blockst\e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj Gene_or_gene_producttCe2: trigger-arg-path: Negative_activation advmod Complextse2: trigger-arg-path: blocks:Negative_activation advmod [lemma='directly'] controllertetrigger-to-trigger-path: e1:interacts:Binding >conj_and [lemma='block'] e2:blocks:Negative_activationtRe2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation >dobj controlledt/e2: ents2Label-mention-ngram: and blocks SHAREDt?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod [lemma='directly'] controllert^e1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='pml'] Gene_or_gene_producttMe1: trigger-arg-path: interacts >prep_with [lemma='pml'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='e7'] theme:Familyt;e2: trigger-arg-path: blocks >dobj [lemma='pml'] controlledt#e2: args2Role-mention-ngram: blockst?e2: trigger-arg-path: lemmatizedTrigger=block:Negative_activation advmod [lemma='directly'] controller:ComplextNe2: trigger-arg-path: Negative_activation advmod controller:Complext2e2: args2Role-mention-ngram: CONTROLLER and blockstme2: trigger-arg-path: lemmatizedTrigger=block advmod [lemma='directly'] Complext8e1: trigger-arg-path: Binding >nsubj [lemma='e7'] Familytge2: trigger-arg-path: blocks advmod [lemma='directly'] controller:Complext7e1: trigger-arg-path: Binding >nsubj [lemma='e7'] themetae2: trigger-arg-path: lemmatizedTrigger=block >dobj [lemma='pml'] controlled:Gene_or_gene_productt]e2: trigger-arg-path: Negative_activation >dobj [lemma='pml'] controlled:Gene_or_gene_producttie2: trigger-arg-path: Negative_activation advmod [lemma='directly'] ComplextGe2: trigger-arg-path: lemmatizedTrigger=block advmod Complext-e2: trigger-arg-path: blocks >dobj controlledtUtrigger-to-trigger-path: e1:interacts:Binding >conj_and e2:blocks:Negative_activationtHe1: trigger-arg-path: interacts:Binding >nsubj [lemma='e7'] theme:Familyt&interceding-token ngrams: which blockst*interceding-token ngrams: which blocks thetJe1: trigger-arg-path: binds >nsubj [lemma='hk'] theme:Gene_or_gene_productt#interceding-token ngrams: ( PKB andt.e1: args2Role-mention-ngram: THEME effectivelytNe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk'] themet/e2: ents2Label-mention-ngram: FAMILY binding tot-interceding-token ngrams: blocks the activityt.interceding-token ngrams: process is activatedt2interceding-token ngrams: glycogen synthase kinasetDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT effectively bindstDe1: trigger-arg-path: binds >nsubj [lemma='hk'] Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk'] Gene_or_gene_productt)interceding-token ngrams: synthase kinasetFe1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk'] themet)interceding-token ngrams: this process ist=e1: trigger-arg-path: binds:Binding >nsubj [lemma='hk'] themet\e2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='VDAC'] Gene_or_gene_productt)interceding-token ngrams: an inhibitor oftVe1: trigger-arg-path: binds:Binding >prep_to [lemma='vdac'] theme:Gene_or_gene_productt9e1: trigger-arg-path: binds >prep_to [lemma='vdac'] themetJe2: trigger-arg-path: binding >prep_to [lemma='VDAC'] Gene_or_gene_productt&interceding-token ngrams: kinase 3betat2e1: ents2Label-mention-ngram: effectively binds tot.e1: args2Role-mention-ngram: effectively bindstce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk'] theme:Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding >prep_to [lemma='VDAC'] themetCe2: trigger-arg-path: binding:Binding >nn [lemma='hk'] theme:Familytbe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='VDAC'] theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='VDAC'] themet%interceding-token ngrams: PKB and Aktt0e1: args2Role-mention-ngram: mitochondrial THEMEtXe2: trigger-arg-path: binding:Binding >prep_to [lemma='VDAC'] theme:Gene_or_gene_productt&interceding-token ngrams: GSK3beta ) ,t!interceding-token ngrams: Akt ) ,tHe1: trigger-arg-path: binds >prep_to [lemma='vdac'] Gene_or_gene_productt4e1: args2Role-mention-ngram: the mitochondrial THEMEt.e1: args2Role-mention-ngram: the mitochondrialtPe2: trigger-arg-path: Binding >prep_to [lemma='VDAC'] theme:Gene_or_gene_producttnn [lemma='hk'] themetge1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vdac'] theme:Gene_or_gene_productt*interceding-token ngrams: 3beta ( GSK3betat interceding-token ngrams: or AkttJe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vdac'] themet$interceding-token ngrams: process ist(interceding-token ngrams: , an inhibitort%interceding-token ngrams: kinase B ortae1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vdac'] Gene_or_gene_productt9shortest-path: nsubjpass >appos >prep_of >nnt?shortest-path: nsubjpass [lemma='3beta'] >appos [lemma='inhibitor'] >prep_of [lemma='binding'] >nn [lemma='hk']t?interceding-tokens-full-span: and this process is activated by protein kinase B or Akt ( PKB and Akt ) , which blocks the activity of glycogen synthase kinase 3beta ( GSK3beta ) , an inhibitor oft&interceding-token ngrams: inhibitor oftFe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hk'] themet\trigger-to-trigger-path: e1:binds:Binding nsubjpass >appos >prep_of e2:binding:BindingtUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hk'] theme:Familyt1e1: args2Role-mention-ngram: effectively binds totJe1: trigger-arg-path: Binding >prep_to [lemma='vdac'] Gene_or_gene_productt$interceding-token ngrams: GSK3beta )t4e1: args2Role-mention-ngram: THEME effectively bindst;e2: trigger-arg-path: binding >nn [lemma='hk'] theme:FamilytRe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='vdac'] themet!interceding-token ngrams: PKB andt;e2: trigger-arg-path: binding >prep_to [lemma='VDAC'] themet6e1: ents2Label-mention-ngram: the mitochondrial SHAREDt"interceding-token ngrams: kinase Btde2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='VDAC'] Gene_or_gene_producttinterceding-token ngrams: Akt )t(interceding-token ngrams: , which blockst interceding-token ngrams: ) , ant2e1: ents2Label-mention-ngram: to the mitochondrialtMe2: trigger-arg-path: lemmatizedTrigger=binding >prep_to [lemma='VDAC'] themetje2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_to [lemma='VDAC'] theme:Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hk'] theme:FamilytRe1: trigger-arg-path: binds:Binding >nsubj [lemma='hk'] theme:Gene_or_gene_productt/e1: ents2Label-mention-ngram: effectively bindst5e2: trigger-arg-path: Binding >nn [lemma='hk'] Familyt!interceding-token ngrams: 3beta (t"interceding-token ngrams: synthaset7e1: trigger-arg-path: Binding >nsubj [lemma='hk'] themet5e1: trigger-arg-path: binds >nsubj [lemma='hk'] themet.interceding-token ngrams: activity of glycogent>e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT effectivelytYe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vdac'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: effectivelytNe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hk'] themet+interceding-token ngrams: glycogen synthaset"interceding-token ngrams: or Akt (tinterceding-token ngrams: PKBtFe1: trigger-arg-path: Binding >nsubj [lemma='hk'] Gene_or_gene_producttinterceding-token ngrams: Akt (t1e1: args2Role-mention-ngram: to the mitochondrialtNe1: trigger-arg-path: binds >prep_to [lemma='vdac'] theme:Gene_or_gene_productt=e2: trigger-arg-path: binding:Binding >nn [lemma='hk'] FamilytJe2: trigger-arg-path: Binding >prep_to [lemma='VDAC'] Gene_or_gene_productt"interceding-token ngrams: B or Aktt4e2: trigger-arg-path: Binding >nn [lemma='hk'] themet#interceding-token ngrams: Akt ( PKBt/interceding-token ngrams: synthase kinase 3betat,e2: ents2Label-mention-ngram: FAMILY bindingt;e1: trigger-arg-path: Binding >prep_to [lemma='vdac'] themetOe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='hk'] Familyt&interceding-token ngrams: ( GSK3beta )t/e1: ents2Label-mention-ngram: the mitochondrialt[e1: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='hk'] theme:Gene_or_gene_productt%interceding-token ngrams: of glycogent;e2: trigger-arg-path: Binding >prep_to [lemma='VDAC'] themet#interceding-token ngrams: and Akt )t*interceding-token ngrams: and this processtLe1: trigger-arg-path: Binding >nsubj [lemma='hk'] theme:Gene_or_gene_producttLe1: trigger-arg-path: binds:Binding >nsubj [lemma='hk'] Gene_or_gene_productt_e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='vdac'] theme:Gene_or_gene_producttinterceding-token ngrams: B ortAe1: trigger-arg-path: binds:Binding >prep_to [lemma='vdac'] themet]e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='hk'] Gene_or_gene_producttPe1: trigger-arg-path: binds:Binding >prep_to [lemma='vdac'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='hk'] FamilytPe1: trigger-arg-path: Binding >prep_to [lemma='vdac'] theme:Gene_or_gene_productt&interceding-token ngrams: an inhibitort(e1: args2Role-mention-ngram: effectivelyt2e1: ents2Label-mention-ngram: mitochondrial SHAREDt5e2: trigger-arg-path: binding >nn [lemma='hk'] Familyt.interceding-token ngrams: of glycogen synthasetRe2: trigger-arg-path: binding:Binding >prep_to [lemma='VDAC'] Gene_or_gene_producttPe2: trigger-arg-path: binding >prep_to [lemma='VDAC'] theme:Gene_or_gene_productt*interceding-token ngrams: protein kinase Bt$interceding-token ngrams: ( GSK3betat4e2: trigger-arg-path: binding >nn [lemma='hk'] themet;e2: trigger-arg-path: Binding >nn [lemma='hk'] theme:Familytinterceding-token ngrams: 3betat?trigger-to-trigger-path: e1:binds:Binding nsubjpass [lemma='3beta'] >appos [lemma='inhibitor'] >prep_of [lemma='binding'] e2:binding:Bindingt(interceding-token ngrams: kinase 3beta (tinterceding-token ngrams: ( PKBt.interceding-token ngrams: activated by proteintge1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] Gene_or_gene_producttNe2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] theme:Familyt'interceding-token ngrams: sufficient totYe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] themetGe2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] themet?e1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] themet`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] theme:Familytge1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] Gene_or_gene_producttRe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] Familyt@e2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] Familytge2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] themetye1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] Gene_or_gene_productt@e1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] Familytye2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] Gene_or_gene_productt;e2: trigger-arg-path: Binding:Binding >prep_of theme:Familyt5e2: trigger-arg-path: Binding:Binding >prep_of Familyt?e1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] themet%interceding-token ngrams: to initiatetXe1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] themetje2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] theme:Gene_or_gene_productt`e1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] themetprep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] Gene_or_gene_producttFe1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] theme:FamilytXe2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] themete1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] theme:Familyte2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] theme:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] themet.interceding-token ngrams: initiate apoptosis .t?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] Gene_or_gene_producttFe1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] theme:Familytoe1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] Gene_or_gene_producttGe1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] themet+interceding-token ngrams: is not sufficienttZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] Familyt@e1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] Familytre1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] themetNe1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] theme:Familyt"interceding-token ngrams: initiatet0interceding-token ngrams: sufficient to initiatet`e2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] themetXe1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] theme:Familytme1: trigger-arg-path: binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] theme:Gene_or_gene_producttme2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] theme:Gene_or_gene_producttXe1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] themetue2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] theme:Gene_or_gene_producttme1: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] theme:Gene_or_gene_producttue1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] themetZe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] FamilytRe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] FamilytHe1: trigger-arg-path: binding:Binding >prep_of [lemma='tnfalpha'] Familyt,interceding-token ngrams: initiate apoptosistoe2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] Gene_or_gene_producttYe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] themet/interceding-token ngrams: to initiate apoptosistje1: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr1'] themetHe2: trigger-arg-path: Binding:Binding >prep_of [lemma='tnfalpha'] Familytre2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='tnfalpha'] >prep_to [lemma='tnfr2'] themetFe2: trigger-arg-path: Binding >prep_of [lemma='tnfalpha'] theme:Familyt(interceding-token ngrams: not sufficientt+interceding-token ngrams: not sufficient totGinterceding-tokens-full-span: is not sufficient to initiate apoptosis .tSe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='ra'] controlled:Familyt(interceding-token ngrams: . Grb2 couplest]e1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='ra'] controlled:Familytje1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn controller:Simple_chemicalt(interceding-token ngrams: the SH3 domaintNe1: trigger-arg-path: activated:Positive_activation >agent >nn Simple_chemicaltDe1: trigger-arg-path: Positive_activation >agent >nn Simple_chemicaltke1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mso'] >nn [lemma='guanine'] Simple_chemicaltWe2: trigger-arg-path: Binding dep [lemma='ra'] theme:FamilytVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mso'] Gene_or_gene_productt.interceding-token ngrams: exchange factor mSOStOe1: trigger-arg-path: Positive_activation >agent >nn controller:Simple_chemicaltce1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='ra'] Familyt,e1: args2Role-mention-ngram: is activated bytZe1: trigger-arg-path: activated >agent [lemma='mso'] >nn [lemma='guanine'] Simple_chemicaltne1: trigger-arg-path: activated:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] Simple_chemicaltde1: trigger-arg-path: Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] Simple_chemicalt5e2: trigger-arg-path: Binding >nn [lemma='mso'] themetde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mso'] theme:Gene_or_gene_producttVe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='ra'] controlledt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mso'] Gene_or_gene_productt.e1: args2Role-mention-ngram: by Ras CONTROLLERtGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mso'] themet)interceding-token ngrams: which binds thet\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='mso'] theme:Gene_or_gene_productt:e2: trigger-arg-path: complex:Binding dep themetFe1: trigger-arg-path: Positive_activation >nsubjpass controlled:FamilytQe2: trigger-arg-path: Binding dep [lemma='ra'] Familyt*e1: ents2Label-mention-ngram: is activatedte1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] Simple_chemicaltoe1: trigger-arg-path: Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controller:Simple_chemicalt'interceding-token ngrams: SH3 domain oftSe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='ra'] controlledt1e1: trigger-arg-path: activated >nsubjpass Familyt9e2: trigger-arg-path: complex dep theme:Familyt_e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent >nn Simple_chemicalt5e2: trigger-arg-path: complex >nn [lemma='mso'] themetXe2: trigger-arg-path: complex:Binding dep [lemma='ra'] themetPe2: trigger-arg-path: Binding dep [lemma='ra'] themet*interceding-token ngrams: the adaptor Grb2tve1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mso'] >nn [lemma='guanine'] controller:Simple_chemicalt.e1: ents2Label-mention-ngram: activated by Rast>e1: trigger-arg-path: activated >nsubjpass [lemma='ra'] Familyt3e2: trigger-arg-path: complex dep Familyt9e2: trigger-arg-path: Binding dep theme:FamilytPe2: trigger-arg-path: complex dep [lemma='ra'] themetke2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep [lemma='ra'] Familyt&interceding-token ngrams: adaptor Grb2t%interceding-token ngrams: the adaptortEe2: trigger-arg-path: lemmatizedTrigger=complex dep FamilytWe2: trigger-arg-path: complex dep [lemma='ra'] theme:Familyt'interceding-token ngrams: domain of thetBe1: trigger-arg-path: activated >nsubjpass [lemma='ra'] controlledtOe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='ra'] FamilytPe1: trigger-arg-path: activated:Positive_activation >nsubjpass controlled:Familyt$e1: ents2Label-mention-ngram: by Rast!interceding-token ngrams: the SH3t(interceding-token ngrams: adaptor Grb2 .tEe1: trigger-arg-path: activated >agent >nn controller:Simple_chemicaltEe1: trigger-arg-path: activated:Positive_activation >nsubjpass FamilytJe2: trigger-arg-path: complex >nn [lemma='mso'] theme:Gene_or_gene_productt&interceding-token ngrams: mSOS , whicht-e1: ents2Label-mention-ngram: is activated bytRe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='ra'] FamilytJe2: trigger-arg-path: Binding >nn [lemma='mso'] theme:Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep theme:FamilytRe2: trigger-arg-path: complex:Binding >nn [lemma='mso'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=activate >agent >nn Simple_chemicalt%interceding-token ngrams: Grb2 . Grb2t2e2: trigger-arg-path: complex dep themetDe2: trigger-arg-path: lemmatizedTrigger=complex dep themet interceding-token ngrams: mSOS ,tge1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='ra'] controlledt1e1: ents2Label-mention-ngram: Ras SIMPLE_CHEMICALt2e2: trigger-arg-path: Binding dep themet interceding-token ngrams: Grb2 .t:e1: trigger-arg-path: activated >agent >nn Simple_chemicalt-e1: args2Role-mention-ngram: activated by Rastne1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='ra'] controlled:FamilytDe2: trigger-arg-path: complex >nn [lemma='mso'] Gene_or_gene_producttQe2: trigger-arg-path: complex dep [lemma='ra'] Familyt%interceding-token ngrams: couples thetAe2: trigger-arg-path: complex:Binding dep theme:FamilytLe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep themet_e1: trigger-arg-path: Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controllert'interceding-token ngrams: binds the SH3tBe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass Familytinterceding-token ngrams: mSOStce2: trigger-arg-path: lemmatizedTrigger=complex dep [lemma='ra'] Familyt%interceding-token ngrams: factor mSOSt#e1: args2Role-mention-ngram: by Rast$interceding-token ngrams: SH3 domaintLe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='ra'] controlledtbe2: trigger-arg-path: lemmatizedTrigger=complex dep [lemma='ra'] themetVe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass Familyt*interceding-token ngrams: Grb2 couples thetie2: trigger-arg-path: lemmatizedTrigger=complex dep [lemma='ra'] theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controller:Simple_chemicalt;e1: trigger-arg-path: Positive_activation >nsubjpass FamilytVe1: trigger-arg-path: lemmatizedTrigger=activate >agent >nn controller:Simple_chemicaltqe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep [lemma='ra'] theme:FamilytIe1: trigger-arg-path: activated >nsubjpass [lemma='ra'] controlled:Familytje2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep [lemma='ra'] themetMe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass controlled:Familytze1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controllertUe1: trigger-arg-path: activated >agent [lemma='mso'] >nn [lemma='guanine'] controllertHe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='ra'] Familyt1e1: ents2Label-mention-ngram: SHARED is activatedtOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='mso'] themetfe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mso'] >nn [lemma='guanine'] controllert interceding-token ngrams: . Grb2tDe2: trigger-arg-path: Binding >nn [lemma='mso'] Gene_or_gene_producttYe1: trigger-arg-path: activated:Positive_activation >agent >nn controller:Simple_chemicalt4e1: args2Role-mention-ngram: CONTROLLED is activatedtKe2: trigger-arg-path: lemmatizedTrigger=complex dep theme:Familyt(interceding-token ngrams: of the adaptort3e2: trigger-arg-path: Binding dep FamilytMe2: trigger-arg-path: lemmatizedTrigger=complex:Binding dep Familyt4e1: ents2Label-mention-ngram: by Ras SIMPLE_CHEMICALt=e2: trigger-arg-path: complex:Binding >nn [lemma='mso'] themet&interceding-token ngrams: Grb2 couplestye1: trigger-arg-path: activated:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controller:Simple_chemicaltYe2: trigger-arg-path: complex:Binding dep [lemma='ra'] Familyt_e2: trigger-arg-path: complex:Binding dep [lemma='ra'] theme:Familyt!interceding-token ngrams: couplestae1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass controlled:Familytnsubjpass controlled:Familyt#interceding-token ngrams: binds thetee1: trigger-arg-path: activated >agent [lemma='mso'] >nn [lemma='guanine'] controller:Simple_chemicaltie1: trigger-arg-path: activated:Positive_activation >agent [lemma='mso'] >nn [lemma='guanine'] controllert?interceding-tokens-full-span: nucleotide exchange factor mSOS , which binds the SH3 domain of the adaptor Grb2 . Grb2 couples thet)e1: args2Role-mention-ngram: is activatedt'interceding-token ngrams: factor mSOS ,tLe2: trigger-arg-path: complex:Binding >nn [lemma='mso'] Gene_or_gene_productt;e2: trigger-arg-path: complex:Binding dep FamilytZe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='ra'] controlled:Familyt+e1: args2Role-mention-ngram: Ras CONTROLLERt%interceding-token ngrams: 2 kinases .t`e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='mek'] theme:Gene_or_gene_productt+interceding-token ngrams: Inactive ERK1 andt)e1: args2Role-mention-ngram: that in turnthe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erk'] theme:Gene_or_gene_productt#interceding-token ngrams: kinases .t interceding-token ngrams: mainlyt+interceding-token ngrams: is mainly locatedtZe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='mek'] Gene_or_gene_producttAe2: trigger-arg-path: heterodimer:Binding >nn [lemma='mek'] themet,e1: ents2Label-mention-ngram: SHARED that int(interceding-token ngrams: where it formstVe2: trigger-arg-path: heterodimer:Binding >nn [lemma='mek'] theme:Gene_or_gene_productt9e2: trigger-arg-path: heterodimer >nn [lemma='mek'] themet@e1: ents2Label-mention-ngram: and activates GENE_OR_GENE_PRODUCTt'interceding-token ngrams: and 2 kinasest"interceding-token ngrams: InactivetHe2: trigger-arg-path: heterodimer >nn [lemma='mek'] Gene_or_gene_producttPe2: trigger-arg-path: heterodimer:Binding >nn [lemma='mek'] Gene_or_gene_productt,interceding-token ngrams: cytoplasm where itt*e1: ents2Label-mention-ngram: that in turntnn [lemma='erk'] theme:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER that int!interceding-token ngrams: locatedt`e2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erk'] theme:Gene_or_gene_producttNe2: trigger-arg-path: heterodimer >nn [lemma='mek'] theme:Gene_or_gene_productt5e1: ents2Label-mention-ngram: turn phosphorylates andtbe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erk'] Gene_or_gene_producttKe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erk'] themet,e1: args2Role-mention-ngram: CONTROLLER thattNe2: trigger-arg-path: heterodimer >nn [lemma='erk'] theme:Gene_or_gene_productt)interceding-token ngrams: cytoplasm wheret-interceding-token ngrams: the cytoplasm wheretSe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='erk'] themet$e1: args2Role-mention-ngram: that int)e1: ents2Label-mention-ngram: SHARED thattbe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='mek'] Gene_or_gene_productt"interceding-token ngrams: and 2 istFCSSPATH: ROOT >conj_and >dobj >rcmod >dobj >rcmod ++ ROOT >advcl >dobjt(interceding-token ngrams: mainly locatedt$interceding-token ngrams: . Inactivetinterceding-token ngrams: 2 ist+interceding-token ngrams: mainly located inthe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='mek'] theme:Gene_or_gene_productt,interceding-token ngrams: kinases . Inactivet)interceding-token ngrams: . Inactive ERK1tAe2: trigger-arg-path: heterodimer:Binding >nn [lemma='erk'] themet"interceding-token ngrams: it formst%e1: ents2Label-mention-ngram: that int9e2: trigger-arg-path: heterodimer >nn [lemma='erk'] themetKe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='mek'] themet(interceding-token ngrams: located in thetuinterceding-tokens-full-span: and 2 kinases . Inactive ERK1 and 2 is mainly located in the cytoplasm where it forms at$interceding-token ngrams: it forms at#interceding-token ngrams: 2 kinasestHe2: trigger-arg-path: heterodimer >nn [lemma='erk'] Gene_or_gene_productt%interceding-token ngrams: 2 is mainlyt"interceding-token ngrams: where ittPe2: trigger-arg-path: heterodimer:Binding >nn [lemma='erk'] Gene_or_gene_productt'interceding-token ngrams: Inactive ERK1tZe2: trigger-arg-path: lemmatizedTrigger=heterodimer >nn [lemma='erk'] Gene_or_gene_producttSe2: trigger-arg-path: lemmatizedTrigger=heterodimer:Binding >nn [lemma='mek'] themet#interceding-token ngrams: is mainlyt$interceding-token ngrams: located int+e1: ents2Label-mention-ngram: and 2 proteint?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt%e1: ents2Label-mention-ngram: A ) andt!e1: args2Role-mention-ngram: MEK1t>e2: trigger-arg-path: activate >dobj [lemma='erk1'] controlledtee2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='erk1'] controlled:Gene_or_gene_productt2e1: ents2Label-mention-ngram: 2 protein expressiont"interceding-token ngrams: in othert$e1: args2Role-mention-ngram: A ) andtze1: trigger-arg-path: Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt%e1: args2Role-mention-ngram: MEK1 andtZe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='erk1'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj >nn Gene_or_gene_productt1e2: ents2Label-mention-ngram: SHARED agonists maytIe2: trigger-arg-path: activate >nsubj >nn controller:Gene_or_gene_producttme1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controllert*e1: args2Role-mention-ngram: ) and inhibittwe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: agonists may activatet\e1: trigger-arg-path: inhibit:Negative_regulation >nsubj >nn controller:Gene_or_gene_productt&interceding-token ngrams: cell systemstZe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj >nn controllert,e1: ents2Label-mention-ngram: ligands reducet,interceding-token ngrams: other cell systemstde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj >nn Gene_or_gene_productt\e2: trigger-arg-path: activate:Positive_activation >dobj [lemma='erk1'] Gene_or_gene_producttSe2: trigger-arg-path: activate >dobj [lemma='erk1'] controlled:Gene_or_gene_productt'interceding-token ngrams: in other cellt!e1: ents2Label-mention-ngram: A )tpe2: trigger-arg-path: activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt*e2: ents2Label-mention-ngram: may activatet(e1: args2Role-mention-ngram: reduce MEK1t%e1: ents2Label-mention-ngram: ligandstye2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=activate >dobj [lemma='erk1'] controlledt1e1: args2Role-mention-ngram: 2 protein expressiont$e1: args2Role-mention-ngram: ligandstye2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_producttme2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert?e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj >nn controller:Gene_or_gene_productt3e1: ents2Label-mention-ngram: SHARED ligands reducet4e2: args2Role-mention-ngram: CONTROLLER agonists maytge2: trigger-arg-path: activate:Positive_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_productt)e1: args2Role-mention-ngram: expression (tde2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='erk1'] controlledt4e2: trigger-arg-path: activate >nsubj >nn controllert0e1: ents2Label-mention-ngram: and inhibit SHAREDt$interceding-token ngrams: other cellt4e2: args2Role-mention-ngram: may activate CONTROLLEDt,e1: args2Role-mention-ngram: reduce MEK1 andtne2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >dobj [lemma='erk1'] Gene_or_gene_producttee2: trigger-arg-path: activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: agonists mayt,e1: ents2Label-mention-ngram: expression ( At1e1: ents2Label-mention-ngram: ligands reduce MEK1t&e1: args2Role-mention-ngram: 2 proteintRe2: trigger-arg-path: activate:Positive_activation >nsubj >nn Gene_or_gene_productt)e2: args2Role-mention-ngram: may activatet?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] Gene_or_gene_producttYe1: trigger-arg-path: inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controllert#interceding-token ngrams: systems ,t*e1: args2Role-mention-ngram: and 2 proteint]e2: trigger-arg-path: activate:Positive_activation >nsubj >nn controller:Gene_or_gene_productt?e2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttce1: trigger-arg-path: inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt2e2: args2Role-mention-ngram: agonists may activatet'e1: ents2Label-mention-ngram: 2 proteintue1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttinterceding-token ngrams: B ) .t[e2: trigger-arg-path: activate >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert e1: args2Role-mention-ngram: A )t!e1: ents2Label-mention-ngram: ( At)e2: args2Role-mention-ngram: agonists mayt,e1: ents2Label-mention-ngram: SHARED ligandste1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controllert?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert#e1: ents2Label-mention-ngram: ( A )t0e1: ents2Label-mention-ngram: inhibit SHARED andt"e1: args2Role-mention-ngram: ( A )t*e1: ents2Label-mention-ngram: expression (tRe2: trigger-arg-path: activate:Positive_activation >dobj [lemma='erk1'] controlledt#CSSPATH: ROOT >pobj >rcmod ++ ROOT t+e1: ents2Label-mention-ngram: ) and inhibittwe1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt1e2: ents2Label-mention-ngram: may activate SHAREDt?e1: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt0e1: args2Role-mention-ngram: ligands reduce MEK1t(e1: ents2Label-mention-ngram: MEK1 and 2tGe1: trigger-arg-path: inhibit:Negative_regulation >nsubj >nn controllert?e1: trigger-arg-path: inhibit:Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt/e1: args2Role-mention-ngram: CONTROLLER ligandst?e2: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_producttGinterceding-tokens-full-span: ( B ) . However , in other cell systems ,t2e1: ents2Label-mention-ngram: protein expression (tke1: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controllert+e1: args2Role-mention-ngram: ligands reducetQe1: trigger-arg-path: inhibit:Negative_regulation >nsubj >nn Gene_or_gene_productt+e1: args2Role-mention-ngram: expression ( Atee1: trigger-arg-path: Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controllert6e1: args2Role-mention-ngram: CONTROLLER ligands reducetne1: trigger-arg-path: inhibit >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] controller:Gene_or_gene_productt$interceding-token ngrams: , in othert>e2: trigger-arg-path: activate >nsubj >nn Gene_or_gene_productt-e1: ents2Label-mention-ngram: reduce MEK1 andt'e1: args2Role-mention-ngram: MEK1 and 2t!interceding-token ngrams: systemst e1: args2Role-mention-ngram: ( AtIe2: trigger-arg-path: Positive_activation >dobj [lemma='erk1'] controlledtSe2: trigger-arg-path: Positive_activation >dobj [lemma='erk1'] Gene_or_gene_productt^e2: trigger-arg-path: Positive_activation >dobj [lemma='erk1'] controlled:Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=activate >nsubj >nn controller:Gene_or_gene_producttHe2: trigger-arg-path: activate >dobj [lemma='erk1'] Gene_or_gene_producttoe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ligand'] >nn [lemma='ppar-gamma'] Gene_or_gene_productt1e1: args2Role-mention-ngram: protein expression (toe2: trigger-arg-path: activate:Positive_activation >nsubj [lemma='agonist'] >nn [lemma='ppar-gamma'] controllert&interceding-token ngrams: However , intHe2: trigger-arg-path: activate:Positive_activation >nsubj >nn controllert(interceding-token ngrams: cell systems ,tFe2: trigger-arg-path: lemmatizedTrigger=activate >nsubj >nn controllert)e1: ents2Label-mention-ngram: reduce MEK1t3e1: args2Role-mention-ngram: and inhibit CONTROLLEDt'interceding-token ngrams: PI3K pathwaystwe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation dep [lemma='erk'] >vmod [lemma='mediate'] e2:mediated:Positive_regulationtDe1: trigger-arg-path: interaction >prep_between [lemma='mapk'] themet#e2: ents2Label-mention-ngram: Ser84t@e1: trigger-arg-path: Binding >prep_between [lemma='mapk'] themetWshortest-path: dep [lemma='erk']t!interceding-token ngrams: includet*interceding-token ngrams: pathways includetUe1: trigger-arg-path: Binding >prep_between [lemma='mapk'] theme:Gene_or_gene_producttinterceding-token ngrams: ( D )t+e2: ents2Label-mention-ngram: Ser84 and 114tjtrigger-to-trigger-path: e1:interaction:Binding dep >vmod e2:mediated:Positive_regulationtse1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mapk'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mapk'] theme:Gene_or_gene_producttinterceding-token ngrams: ( DtLe1: trigger-arg-path: interaction:Binding >prep_between [lemma='mapk'] themetfe2: trigger-arg-path: mediated:Positive_regulation dept6e2: ents2Label-mention-ngram: phosphorylation at Ser84t,interceding-token ngrams: pathways include (t^e1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mapk'] themet&e2: ents2Label-mention-ngram: at Ser84t=e2: trigger-arg-path: mediated prep_between [lemma='mapk'] Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mapk'] themet#interceding-token ngrams: include (tme1: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='mapk'] Gene_or_gene_productt%interceding-token ngrams: include ( DtQe2: trigger-arg-path: mediated:Positive_regulation prep_between [lemma='mapk'] theme:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='mapk'] Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=mediate prep_between [lemma='mapk'] theme:Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=mediate:Positive_regulation prep_between [lemma='mapk'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: and 114tGe2: trigger-arg-path: mediated prep_between [lemma='mapk'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn [lemma='transcription'] controllert;e2: trigger-arg-path: Binding >prep_to [lemma='cdk2'] themetoe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] theme:Familyt7e1: trigger-arg-path: upregulates nn BioProcesst?e1: trigger-arg-path: Positive_activation nn controllert4e1: ents2Label-mention-ngram: BIOPROCESS factor thatt9e2: trigger-arg-path: binds >prep_to [lemma='cdk2'] themetge2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='product'] >nn [lemma='cyclin'] theme:Familytae2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='product'] >nn [lemma='cyclin'] FamilytVe2: trigger-arg-path: binds >nsubj [lemma='product'] >nn [lemma='cyclin'] theme:FamilytKe1: trigger-arg-path: upregulates:Positive_activation nn BioProcesst[e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj Generic_entityt'e1: args2Role-mention-ngram: E gene andt-e1: args2Role-mention-ngram: that targets thet$e2: args2Role-mention-ngram: producttHe2: trigger-arg-path: binds >prep_to [lemma='cdk2'] Gene_or_gene_producttKe1: trigger-arg-path: Positive_activation >dobj [lemma='it'] Generic_entityt6e1: trigger-arg-path: upregulates >dobj Generic_entityt#e1: args2Role-mention-ngram: E genet`e1: trigger-arg-path: upregulates nn [lemma='transcription'] controllertqe1: trigger-arg-path: lemmatizedTrigger=upregulate nn [lemma='transcription'] controllerte1: args2Role-mention-ngram: Et0e1: args2Role-mention-ngram: factor that targetst-e1: ents2Label-mention-ngram: and upregulatestCe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj controlledt/e2: args2Role-mention-ngram: THEME gene productt)e1: ents2Label-mention-ngram: targets thet1e2: ents2Label-mention-ngram: SHARED gene producttge2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk2'] theme:Gene_or_gene_productt|e1: trigger-arg-path: lemmatizedTrigger=upregulate nn [lemma='transcription'] controller:BioProcesst?e1: trigger-arg-path: Positive_activation nn BioProcesst?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn [lemma='transcription'] BioProcesstUe1: trigger-arg-path: upregulates:Positive_activation >dobj controlled:Generic_entitytte1: trigger-arg-path: upregulates:Positive_activation nn [lemma='transcription'] controllertVe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk2'] theme:Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk2'] theme:Gene_or_gene_producttJe2: trigger-arg-path: Binding >prep_to [lemma='cdk2'] Gene_or_gene_producttFe1: trigger-arg-path: upregulates:Positive_activation >dobj controlledtWe1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='it'] Generic_entitytGe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj Generic_entitytqe1: trigger-arg-path: lemmatizedTrigger=upregulate nn [lemma='transcription'] BioProcesst4e1: ents2Label-mention-ngram: and upregulates SHAREDt`e1: trigger-arg-path: upregulates nn [lemma='transcription'] BioProcesst3e1: args2Role-mention-ngram: CONTROLLER factor thattPe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='it'] controlledtde1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='it'] controlledtPe2: trigger-arg-path: binds >nsubj [lemma='product'] >nn [lemma='cyclin'] Familyt*e2: args2Role-mention-ngram: product bindst.e2: ents2Label-mention-ngram: product binds tot\e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn controllertHe1: trigger-arg-path: lemmatizedTrigger=upregulate nn controllertse1: trigger-arg-path: Positive_activation nn [lemma='transcription'] controller:BioProcessthe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='it'] Generic_entityt(e1: args2Role-mention-ngram: targets thet*e2: ents2Label-mention-ngram: gene producttOe2: trigger-arg-path: binds >nsubj [lemma='product'] >nn [lemma='cyclin'] themetJe1: trigger-arg-path: Positive_activation nn controller:BioProcesstge1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn controller:BioProcesstVe1: trigger-arg-path: upregulates:Positive_activation nn controller:BioProcesstae2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk2'] Gene_or_gene_productt2e1: ents2Label-mention-ngram: gene and upregulatestQe2: trigger-arg-path: Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] themetNe1: trigger-arg-path: upregulates >dobj [lemma='it'] controlled:Generic_entitytte1: trigger-arg-path: upregulates:Positive_activation nn [lemma='transcription'] BioProcesstRe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='cdk2'] themet)e1: args2Role-mention-ngram: that targetst_e1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='it'] controlled:Generic_entityt+e2: ents2Label-mention-ngram: product bindstAe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk2'] themet?e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn [lemma='transcription'] controller:BioProcesstRe2: trigger-arg-path: Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] Familyt%e1: args2Role-mention-ngram: gene andt`e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='product'] >nn [lemma='cyclin'] themet\e1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation nn BioProcesstPe2: trigger-arg-path: Binding >prep_to [lemma='cdk2'] theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] themet2e1: trigger-arg-path: upregulates >dobj controlledtHe1: trigger-arg-path: lemmatizedTrigger=upregulate nn BioProcesstie2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] Familyt?e1: trigger-arg-path: upregulates >dobj [lemma='it'] controlledt+e1: ents2Label-mention-ngram: cyclin E genet'e2: args2Role-mention-ngram: THEME genetYe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk2'] Gene_or_gene_productte1: trigger-arg-path: upregulates:Positive_activation nn [lemma='transcription'] controller:BioProcesst)e1: args2Role-mention-ngram: the cyclin EtJe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='cdk2'] themet&e1: ents2Label-mention-ngram: gene andtAe1: trigger-arg-path: upregulates >dobj controlled:Generic_entitytGe1: trigger-arg-path: Positive_activation >dobj [lemma='it'] controlledt1e1: args2Role-mention-ngram: gene and upregulatest)e2: args2Role-mention-ngram: gene productthe1: trigger-arg-path: Positive_activation nn [lemma='transcription'] controllert/e1: args2Role-mention-ngram: targets the cyclint5e2: trigger-arg-path: binds:Binding >nsubj >nn FamilytNe2: trigger-arg-path: binds >prep_to [lemma='cdk2'] theme:Gene_or_gene_producttSe1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='it'] controlledt%e1: args2Role-mention-ngram: cyclin Et-e2: trigger-arg-path: binds >nsubj >nn Familyt(e1: ents2Label-mention-ngram: the cyclintVe1: trigger-arg-path: Positive_activation >dobj [lemma='it'] controlled:Generic_entitytRe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj controlled:Generic_entityt3e2: trigger-arg-path: binds >nsubj >nn theme:Familyt-e2: args2Role-mention-ngram: product binds totse1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj [lemma='it'] controlled:Generic_entityt%e2: ents2Label-mention-ngram: productt7e1: trigger-arg-path: upregulates nn controllert&e1: ents2Label-mention-ngram: cyclin EtBe1: trigger-arg-path: upregulates nn controller:BioProcesstKe1: trigger-arg-path: upregulates:Positive_activation nn controllertJe1: trigger-arg-path: upregulates:Positive_activation >dobj Generic_entitytPe2: trigger-arg-path: binds:Binding >prep_to [lemma='cdk2'] Gene_or_gene_producttCe1: trigger-arg-path: upregulates >dobj [lemma='it'] Generic_entitytTe1: trigger-arg-path: lemmatizedTrigger=upregulate >dobj [lemma='it'] Generic_entitytWe2: trigger-arg-path: binds:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] themet/e2: args2Role-mention-ngram: gene product bindstWe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj controlledt.e1: ents2Label-mention-ngram: that targets thetke1: trigger-arg-path: upregulates nn [lemma='transcription'] controller:BioProcesst;e2: trigger-arg-path: binds:Binding >nsubj >nn theme:FamilytXe2: trigger-arg-path: binds:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] Familyt,e1: args2Role-mention-ngram: and upregulatestfe1: trigger-arg-path: lemmatizedTrigger=upregulate:Positive_activation >dobj controlled:Generic_entityt^e2: trigger-arg-path: binds:Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] theme:Familyt0e1: ents2Label-mention-ngram: targets the cyclint(e1: args2Role-mention-ngram: factor thatt1e1: ents2Label-mention-ngram: factor that targetst'e1: args2Role-mention-ngram: the cyclintSe1: trigger-arg-path: lemmatizedTrigger=upregulate nn controller:BioProcesste1: ents2Label-mention-ngram: Et$e1: ents2Label-mention-ngram: E genet*e1: ents2Label-mention-ngram: that targetst7e1: args2Role-mention-ngram: and upregulates CONTROLLEDtbe1: trigger-arg-path: upregulates:Positive_activation >dobj [lemma='it'] controlled:Generic_entitytXe2: trigger-arg-path: Binding >nsubj [lemma='product'] >nn [lemma='cyclin'] theme:Familyt(e1: ents2Label-mention-ngram: E gene andthe1: trigger-arg-path: Positive_activation nn [lemma='transcription'] BioProcesst*e1: ents2Label-mention-ngram: the cyclin Et*e1: args2Role-mention-ngram: cyclin E genet0e2: ents2Label-mention-ngram: gene product bindstOe1: trigger-arg-path: results:Positive_regulation >prep_by Gene_or_gene_productt interceding-token ngrams: . MDM2tinterceding-token ngrams: MDM4t"interceding-token ngrams: and MDM4tEe1: trigger-arg-path: results:Positive_regulation >prep_by controllertKe1: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] controllerte1: trigger: resultst;e1: trigger-arg-path: results >prep_by Gene_or_gene_productt'interceding-token ngrams: at sites neartye1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_producttinterceding-token ngrams: neart&interceding-token ngrams: are releasedt'interceding-token ngrams: MDM2 and MDM4t2e1: args2Role-mention-ngram: results in CONTROLLEDtUe1: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_productt]e1: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_producttIe1: trigger-arg-path: results >prep_by [lemma='ATM'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by Gene_or_gene_productt8e1: ents2Label-mention-ngram: results in phosphorylationt&interceding-token ngrams: MDM2 or MDM4tIe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] themetIe2: trigger-arg-path: Binding >prep_to [lemma='p53'] Gene_or_gene_productt(interceding-token ngrams: released , andt"interceding-token ngrams: at sitesthe1: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_producttinterceding-token ngrams: CHK2t8e2: trigger-arg-path: binds >prep_to [lemma='p53'] themetFe1: trigger-arg-path: results >prep_by controller:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] Gene_or_gene_producttointerceding-tokens-full-span: or CHK2 at sites near MDM2 and MDM4 binding . MDM2 or MDM4 are released , and thetZe1: trigger-arg-path: results:Positive_regulation >prep_by controller:Gene_or_gene_producttee1: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] themetOe2: trigger-arg-path: binds:Binding >prep_to [lemma='p53'] Gene_or_gene_productt$interceding-token ngrams: sites neartXe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] Gene_or_gene_productt#interceding-token ngrams: . MDM2 ort@e2: trigger-arg-path: binds:Binding >prep_to [lemma='p53'] themet"interceding-token ngrams: MDM4 aret(interceding-token ngrams: MDM4 binding .tLe1: trigger-arg-path: lemmatizedTrigger=result >prep_by Gene_or_gene_productt(interceding-token ngrams: binding . MDM2t#interceding-token ngrams: near MDM2tMe2: trigger-arg-path: binds >prep_to [lemma='p53'] theme:Gene_or_gene_productt1e1: trigger-arg-path: results >prep_by controllert)interceding-token ngrams: sites near MDM2tWe1: trigger-arg-path: lemmatizedTrigger=result >prep_by controller:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] controllert$interceding-token ngrams: or CHK2 attPe1: trigger-arg-path: lemmatizedTrigger=result >prep_by [lemma='ATM'] controllert?e1: trigger-arg-path: results >prep_by [lemma='ATM'] controllert!interceding-token ngrams: CHK2 att!interceding-token ngrams: or MDM4t(interceding-token ngrams: are released ,t:e2: trigger-arg-path: Binding >prep_to [lemma='p53'] themetSe1: trigger-arg-path: results:Positive_regulation >prep_by [lemma='ATM'] controllertGe2: trigger-arg-path: binds >prep_to [lemma='p53'] Gene_or_gene_productt$interceding-token ngrams: released ,t!interceding-token ngrams: or CHK2tke1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by controller:Gene_or_gene_productt'interceding-token ngrams: CHK2 at sitest*interceding-token ngrams: and MDM4 bindingt`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] Gene_or_gene_producttne1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by [lemma='ATM'] Gene_or_gene_producttTe1: trigger-arg-path: results >prep_by [lemma='ATM'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: in CONTROLLED byt`e1: trigger-arg-path: Positive_regulation >prep_by [lemma='ATM'] controller:Gene_or_gene_producttOe2: trigger-arg-path: Binding >prep_to [lemma='p53'] theme:Gene_or_gene_producttUe2: trigger-arg-path: binds:Binding >prep_to [lemma='p53'] theme:Gene_or_gene_productt!interceding-token ngrams: MDM2 ortVe1: trigger-arg-path: lemmatizedTrigger=result:Positive_regulation >prep_by controllert%interceding-token ngrams: or MDM4 aret+interceding-token ngrams: MDM4 are releasedtBe1: trigger-arg-path: lemmatizedTrigger=result >prep_by controllert-CSSPATH: ROOT >agent >rcmod ++ ROOT >conj_andt'interceding-token ngrams: near MDM2 andtfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] theme:Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] theme:Gene_or_gene_productt&interceding-token ngrams: MDM4 bindingt*interceding-token ngrams: which results int%interceding-token ngrams: ATM or CHK2t)interceding-token ngrams: , which resultst interceding-token ngrams: by ATMt#interceding-token ngrams: by ATM ort interceding-token ngrams: ATM ort?interceding-tokens-full-span: , which results in phosphorylation of p53 by ATM or CHK2 at sites near MDM2 and MDM4 binding . MDM2 or MDM4 are released , and thet,interceding-token ngrams: in phosphorylationt0interceding-token ngrams: phosphorylation of p53t4interceding-token ngrams: results in phosphorylationt$interceding-token ngrams: p53 by ATMt'interceding-token ngrams: which resultst/interceding-token ngrams: in phosphorylation oft*e1: args2Role-mention-ngram: can also bindtLe1: trigger-arg-path: bind >prep_to [lemma='p53'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: bind directlytFe1: trigger-arg-path: bind >prep_to [lemma='p53'] Gene_or_gene_productt:e1: trigger-arg-path: Binding >prep_to [lemma='p53'] themetXe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] Gene_or_gene_productt/e1: args2Role-mention-ngram: also bind directlytIe2: trigger-arg-path: Binding >nsubj [lemma='brca1'] Gene_or_gene_productt*e2: args2Role-mention-ngram: can also bindt`e1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] Gene_or_gene_productt+e2: ents2Label-mention-ngram: bind directlyt^e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] theme:Gene_or_gene_productt&e1: args2Role-mention-ngram: also bindt&e2: args2Role-mention-ngram: also bindtfe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] theme:Gene_or_gene_productt'e2: ents2Label-mention-ngram: also bindt7e2: trigger-arg-path: bind >prep_to [lemma='p53'] themet?e1: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] themetXe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] Gene_or_gene_productt0e1: ents2Label-mention-ngram: also bind directlytFe2: trigger-arg-path: bind >nsubj [lemma='brca1'] Gene_or_gene_producttTe2: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: can also bindtFe2: trigger-arg-path: bind >prep_to [lemma='p53'] Gene_or_gene_producttIe1: trigger-arg-path: Binding >prep_to [lemma='p53'] Gene_or_gene_producttIe2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] themet7e1: trigger-arg-path: bind >prep_to [lemma='p53'] themet`e2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] Gene_or_gene_producttTe2: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] theme:Gene_or_gene_productt.e2: ents2Label-mention-ngram: bind directly totQe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] themet'e1: ents2Label-mention-ngram: also bindt7e2: trigger-arg-path: bind >nsubj [lemma='brca1'] themet0e2: ents2Label-mention-ngram: also bind directlytLe2: trigger-arg-path: bind >nsubj [lemma='brca1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] themet/e2: args2Role-mention-ngram: also bind directlytIe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='p53'] themetQe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='p53'] themetOe2: trigger-arg-path: Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttNe1: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] Gene_or_gene_productt.e2: args2Role-mention-ngram: directly to THEMEt+e1: ents2Label-mention-ngram: can also bindtLe2: trigger-arg-path: bind >prep_to [lemma='p53'] theme:Gene_or_gene_producttTe1: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_to [lemma='p53'] theme:Gene_or_gene_productt-e2: args2Role-mention-ngram: bind directly tot^e2: trigger-arg-path: lemmatizedTrigger=bind >nsubj [lemma='brca1'] theme:Gene_or_gene_producttfe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubj [lemma='brca1'] theme:Gene_or_gene_producttNe2: trigger-arg-path: bind:Binding >prep_to [lemma='p53'] Gene_or_gene_producttNe2: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] Gene_or_gene_productt?e2: trigger-arg-path: bind:Binding >nsubj [lemma='brca1'] themet:e2: trigger-arg-path: Binding >nsubj [lemma='brca1'] themet3interceding-token ngrams: vivo ubiquitination assayt%interceding-token ngrams: performed .twe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controllert)interceding-token ngrams: was performed .t/interceding-token ngrams: the stabilization andt)interceding-token ngrams: that Gli3 siRNAt+e1: ents2Label-mention-ngram: siRNA inducest9interceding-token ngrams: co-immunoprecipitationan and int?interceding-tokens-full-span: stabilization , co-immunoprecipitationan and in vivo ubiquitination assay was performed . Importantly , we found that Gli3 siRNA results in the stabilization and activation of p53 , via the prevention oft?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlled:Gene_or_gene_productt6interceding-token ngrams: co-immunoprecipitationan andt*interceding-token ngrams: Importantly , wethe1: trigger-arg-path: Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] Gene_or_gene_productt-interceding-token ngrams: assay was performedtve1: trigger-arg-path: induces:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: siRNA resultst2e1: ents2Label-mention-ngram: siRNA induces SHAREDt\e1: trigger-arg-path: induces:Positive_activation >nsubj >nn controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn controller:Gene_or_gene_producttRe1: trigger-arg-path: induces >nsubj [lemma='sirna'] >nn [lemma='gli3'] controllert-interceding-token ngrams: vivo ubiquitinationt4interceding-token ngrams: , co-immunoprecipitationant(interceding-token ngrams: the preventiont#interceding-token ngrams: assay wastne1: trigger-arg-path: Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] Gene_or_gene_productt'interceding-token ngrams: was performedt+interceding-token ngrams: activation of p53t1interceding-token ngrams: performed . Importantlytce1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='sirna'] >nn [lemma='gli3'] controllert'interceding-token ngrams: prevention oft.interceding-token ngrams: in the stabilizationt+interceding-token ngrams: the prevention oft5e1: args2Role-mention-ngram: CONTROLLER siRNA inducestbe1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj >nn Gene_or_gene_productt0interceding-token ngrams: in vivo ubiquitinationt#interceding-token ngrams: , via thet?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] Gene_or_gene_producttse1: trigger-arg-path: Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controller:Gene_or_gene_producttpe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] Gene_or_gene_producttbe1: trigger-arg-path: induces >dobj [lemma='stabilization'] >nn [lemma='p53'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] Gene_or_gene_productt*e1: args2Role-mention-ngram: siRNA inducestfe1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controllert6interceding-token ngrams: stabilization and activationt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT siRNA inducestme1: trigger-arg-path: induces >dobj [lemma='stabilization'] >nn [lemma='p53'] controlled:Gene_or_gene_productt8interceding-token ngrams: , co-immunoprecipitationan andt,interceding-token ngrams: via the preventiont}e1: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlledtinterceding-token ngrams: Gli3tle1: trigger-arg-path: induces:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlledtXe1: trigger-arg-path: induces >dobj [lemma='stabilization'] >nn [lemma='p53'] controlledtie1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='stabilization'] >nn [lemma='p53'] controlledtBinterceding-token ngrams: stabilization , co-immunoprecipitationant)interceding-token ngrams: found that Gli3tQe1: trigger-arg-path: induces:Positive_activation >nsubj >nn Gene_or_gene_productt2interceding-token ngrams: ubiquitination assay wast"interceding-token ngrams: of p53 ,t.interceding-token ngrams: ubiquitination assayt$interceding-token ngrams: Gli3 siRNAt\e1: trigger-arg-path: induces >nsubj [lemma='sirna'] >nn [lemma='gli3'] Gene_or_gene_productt+interceding-token ngrams: the stabilizationtse1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='stabilization'] >nn [lemma='p53'] Gene_or_gene_productt+interceding-token ngrams: stabilization andt8e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT siRNAtge1: trigger-arg-path: induces >nsubj [lemma='sirna'] >nn [lemma='gli3'] controller:Gene_or_gene_productt#interceding-token ngrams: that Gli3t*interceding-token ngrams: siRNA results intme1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='sirna'] >nn [lemma='gli3'] Gene_or_gene_productt?e1: trigger-arg-path: induces:Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlled:Gene_or_gene_productt,interceding-token ngrams: Gli3 siRNA resultst2interceding-token ngrams: co-immunoprecipitationant#interceding-token ngrams: p53 , viat^e1: trigger-arg-path: Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controllert5e1: args2Role-mention-ngram: siRNA induces CONTROLLEDtxe1: trigger-arg-path: lemmatizedTrigger=induce >nsubj [lemma='sirna'] >nn [lemma='gli3'] controller:Gene_or_gene_productt-e1: args2Role-mention-ngram: CONTROLLER siRNAt)interceding-token ngrams: stabilization ,t~e1: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='stabilization'] >nn [lemma='p53'] controlled:Gene_or_gene_producttGe1: trigger-arg-path: induces:Positive_activation >nsubj >nn controllert{e1: trigger-arg-path: induces:Positive_activation >nsubj [lemma='sirna'] >nn [lemma='gli3'] controller:Gene_or_gene_producttde1: trigger-arg-path: Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlledt$interceding-token ngrams: preventiontOCSSPATH: ROOT >advcl >prepc_by ++ ROOT >ccomp >prep_in >prep_via >prep_of >vmodtye1: trigger-arg-path: Positive_activation >dobj [lemma='stabilization'] >nn [lemma='p53'] controlled:Gene_or_gene_productt'interceding-token ngrams: stabilizationtKe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj >prep_of controllert?e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controller:Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='src'] controller:Gene_or_gene_producttinterceding-token ngrams: EphA2t4interceding-token ngrams: implicating an eHsp90-LRP1t'interceding-token ngrams: , implicatingt~e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='src'] controller:Gene_or_gene_producttSe1: trigger-arg-path: suppressed:Negative_activation >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlled:Gene_or_gene_producttDe2: trigger-arg-path: phosphorylated >agent [lemma='src'] controllertSe2: trigger-arg-path: Positive_regulation >agent [lemma='src'] Gene_or_gene_producttEe1: trigger-arg-path: suppressed >nsubj >prep_of Gene_or_gene_productt%interceding-token ngrams: eHsp90-LRP1t&interceding-token ngrams: reduced cellt_e2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='src'] Gene_or_gene_producttIe1: trigger-arg-path: suppressed:Negative_activation >dobj >nn controlledtYe2: trigger-arg-path: phosphorylated >agent [lemma='src'] controller:Gene_or_gene_productt*interceding-token ngrams: EphA2 activity .tte1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj >prep_of controller:Gene_or_gene_producttge1: trigger-arg-path: Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controllertUe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj >prep_of Gene_or_gene_productt^e1: trigger-arg-path: suppressed:Negative_activation >dobj >nn controlled:Gene_or_gene_productt'interceding-token ngrams: cell motilitytie1: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='signaling'] >nn [lemma='epha2'] controlledt_e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj >prep_of controllertme1: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlledthe1: trigger-arg-path: suppressed >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controllertme2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='src'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Positive_regulation >agent [lemma='src'] controllertne1: trigger-arg-path: suppressed >dobj [lemma='signaling'] >nn [lemma='epha2'] controlled:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='src'] controllertZe1: trigger-arg-path: lemmatizedTrigger=suppress >dobj >nn controlled:Gene_or_gene_productt4interceding-token ngrams: signaling and dramaticallyt;e1: trigger-arg-path: suppressed >nsubj >prep_of controllertXe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='src'] controllertne1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controllertNe2: trigger-arg-path: phosphorylated >agent [lemma='src'] Gene_or_gene_producttOe1: trigger-arg-path: suppressed:Negative_activation >nsubj >prep_of controllertbe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='src'] Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='src'] Gene_or_gene_productt(interceding-token ngrams: an eHsp90-LRP1t(interceding-token ngrams: EphA2 activitytie1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj >prep_of Gene_or_gene_productt"interceding-token ngrams: of EphA2t?e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] Gene_or_gene_productt!interceding-token ngrams: axis intEe1: trigger-arg-path: lemmatizedTrigger=suppress >dobj >nn controlledtYe1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >nn controlledt5e1: trigger-arg-path: suppressed >dobj >nn controlledtwe1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlled:Gene_or_gene_productt+interceding-token ngrams: signaling axis int|e1: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] Gene_or_gene_producttxe1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controller:Gene_or_gene_producttde1: trigger-arg-path: suppressed:Negative_activation >nsubj >prep_of controller:Gene_or_gene_producttPe1: trigger-arg-path: suppressed >nsubj >prep_of controller:Gene_or_gene_productt$interceding-token ngrams: motility ,t2interceding-token ngrams: an eHsp90-LRP1 signalingtBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT also suppressedtre1: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controllertle1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] Gene_or_gene_producttYe1: trigger-arg-path: suppressed >dobj [lemma='signaling'] >nn [lemma='epha2'] controlledt)interceding-token ngrams: cell motility ,t"interceding-token ngrams: motilityt^e2: trigger-arg-path: Positive_regulation >agent [lemma='src'] controller:Gene_or_gene_productt^e1: trigger-arg-path: suppressed >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controllert(interceding-token ngrams: signaling axist0interceding-token ngrams: motility , implicatingt`e1: trigger-arg-path: lemmatizedTrigger=suppress >nsubj >prep_of controller:Gene_or_gene_productt~e1: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='signaling'] >nn [lemma='epha2'] controlled:Gene_or_gene_productt(interceding-token ngrams: implicating antqe1: trigger-arg-path: Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] Gene_or_gene_productt/interceding-token ngrams: eHsp90-LRP1 signalingtie2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='src'] controllert+interceding-token ngrams: of EphA2 activityt*interceding-token ngrams: , implicating ant/interceding-token ngrams: reduced cell motilitytce1: trigger-arg-path: suppressed >dobj [lemma='signaling'] >nn [lemma='epha2'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >nn Gene_or_gene_productt?e1: trigger-arg-path: suppressed:Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controller:Gene_or_gene_productt-interceding-token ngrams: regulation of EphA2t'interceding-token ngrams: in regulationt|e1: trigger-arg-path: Negative_activation >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: suppressed:Negative_activation >nsubj >prep_of Gene_or_gene_producttbe1: trigger-arg-path: Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlledtne1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj >nn controlled:Gene_or_gene_producttse1: trigger-arg-path: suppressed >nsubj [lemma='silencing'] >prep_of [lemma='lrp1'] controller:Gene_or_gene_productt%interceding-token ngrams: implicatingt2interceding-token ngrams: and dramatically reducedt?interceding-tokens-full-span: signaling and dramatically reduced cell motility , implicating an eHsp90-LRP1 signaling axis in regulation of EphA2 activity .tJe1: trigger-arg-path: suppressed >dobj >nn controlled:Gene_or_gene_productt*interceding-token ngrams: in regulation oft?e1: trigger-arg-path: suppressed >dobj >nn Gene_or_gene_productt4interceding-token ngrams: eHsp90-LRP1 signaling axist}e1: trigger-arg-path: lemmatizedTrigger=suppress:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] controlledt*interceding-token ngrams: and dramaticallyt3interceding-token ngrams: dramatically reduced celltinterceding-token ngrams: axist,interceding-token ngrams: axis in regulationtwe1: trigger-arg-path: suppressed:Negative_activation >dobj [lemma='signaling'] >nn [lemma='epha2'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=suppress >dobj >nn Gene_or_gene_producttse1: trigger-arg-path: lemmatizedTrigger=suppress >dobj [lemma='signaling'] >nn [lemma='epha2'] Gene_or_gene_producttAe2: ents2Label-mention-ngram: increased beta1-integrin expressiont+e2: ents2Label-mention-ngram: cortactin andt7e2: ents2Label-mention-ngram: beta1-integrin expressiont)e2: ents2Label-mention-ngram: and inducedt6e2: ents2Label-mention-ngram: increased beta1-integrint9e2: ents2Label-mention-ngram: and induced phosphorylationtPe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] controllertZe2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_productt8e2: ents2Label-mention-ngram: SHARED signaling increasedt@e2: ents2Label-mention-ngram: signaling increased beta1-integrint]e2: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_producttHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] controllert0e2: ents2Label-mention-ngram: and activation andt4e2: ents2Label-mention-ngram: activation and inducedt1e2: ents2Label-mention-ngram: of the cytoskeletalt1e2: ents2Label-mention-ngram: signaling increasedt'e2: ents2Label-mention-ngram: cortactint7e2: ents2Label-mention-ngram: the cytoskeletal proteinstRe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: proteins cortactint8e1: ents2Label-mention-ngram: SHARED signaling increasedt2e2: ents2Label-mention-ngram: cortactin and SHAREDtve2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt3e2: ents2Label-mention-ngram: cytoskeletal proteinstke2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] Gene_or_gene_producttee2: trigger-arg-path: induced:Positive_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt7e2: ents2Label-mention-ngram: expression and activationt;e2: ents2Label-mention-ngram: beta1-integrin expression andt4e2: ents2Label-mention-ngram: proteins cortactin andtae2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation >nsubj [lemma='ha'] controllert.e2: ents2Label-mention-ngram: the cytoskeletalt6e1: ents2Label-mention-ngram: induced SHARED signalingt=e2: ents2Label-mention-ngram: cytoskeletal proteins cortactint,e2: ents2Label-mention-ngram: beta1-integrint6e2: ents2Label-mention-ngram: induced SHARED signalingt*e2: ents2Label-mention-ngram: cytoskeletaltHe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] controllert?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt?e2: ents2Label-mention-ngram: depletion of GENE_OR_GENE_PRODUCTtye1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtte1: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt`trigger-to-trigger-path: e1:induced:Negative_regulation >ccomp e2:attenuated:Negative_regulationtye1: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt~e1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt|e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtZe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_producttttrigger-to-trigger-path: e1:induced:Negative_regulation >ccomp [lemma='attenuate'] e2:attenuated:Negative_regulationtae1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] controllert?e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationtke1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_producttxe1: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtme1: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationtve1: trigger-arg-path: lemmatizedTrigger=induce:Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt]e1: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_producttPe1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] controllerthe1: trigger-arg-path: induced >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlledtee1: trigger-arg-path: induced:Negative_regulation >nsubj [lemma='ha'] controller:Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=induce >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] controlled:PhosphorylationtRe1: trigger-arg-path: Negative_regulation >nsubj [lemma='ha'] Gene_or_gene_productt?e1: trigger-arg-path: induced:Negative_regulation >ccomp [lemma='attenuate'] >nsubjpass [lemma='phosphorylation'] Phosphorylationt9e2: trigger-arg-path: inducing dobj controlledtXe2: trigger-arg-path: lemmatizedTrigger=induce dobj controlled:Phosphorylationt*interceding-token ngrams: total FAK levelst]e2: trigger-arg-path: inducing:Positive_regulation >dobj [lemma='phosphorylation'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] Gene_or_gene_producttke1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] Gene_or_gene_producttIe1: trigger-arg-path: decreases:Positive_regulation >dobj Phosphorylationt^e1: trigger-arg-path: decreases:Positive_regulation >nsubj >nn controller:Gene_or_gene_productt-interceding-token ngrams: CLU siRNA treatmentt0e1: args2Role-mention-ngram: knockdown decreasest)interceding-token ngrams: siRNA treatmenttNe2: trigger-arg-path: lemmatizedTrigger=induce nsubj [lemma='knockdown'] >nn [lemma='CLU'] Gene_or_gene_producttHe2: trigger-arg-path: inducing nsubj [lemma='knockdown'] >nn [lemma='CLU'] Gene_or_gene_productt0e2: args2Role-mention-ngram: inducing CONTROLLEDtUe1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj controlledtCe2: trigger-arg-path: inducing:Positive_regulation >dobj controlledtle1: trigger-arg-path: decreases >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controller:Gene_or_gene_producttNe2: trigger-arg-path: inducing >dobj [lemma='phosphorylation'] Phosphorylationt!interceding-token ngrams: to showtoe1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj >nn controller:Gene_or_gene_producttCe2: trigger-arg-path: inducing:Positive_regulation dobj [lemma='phosphorylation'] Phosphorylationtbe2: trigger-arg-path: inducing:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt?e1: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controller:Gene_or_gene_productt?e2: trigger-arg-path: inducing >dobj controlled:Phosphorylationtce1: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] Phosphorylationt!interceding-token ngrams: We havetSe2: trigger-arg-path: Positive_regulation nsubj [lemma='knockdown'] >nn [lemma='CLU'] controller:Gene_or_gene_productt(interceding-token ngrams: that CLU siRNAt0e2: args2Role-mention-ngram: CONTROLLER inducingt'interceding-token ngrams: cells withouttle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj Phosphorylationt'interceding-token ngrams: FAK levels byt-e2: ents2Label-mention-ngram: inducing SHAREDt+interceding-token ngrams: without affectingtQe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj controlled:Phosphorylationt[e1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn controller:Gene_or_gene_productt interceding-token ngrams: serum-t|e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controllert\e2: trigger-arg-path: inducing:Positive_regulation nsubj >nn Gene_or_gene_productt'interceding-token ngrams: analysis . WetSe1: trigger-arg-path: decreases:Positive_regulation >nsubj >nn Gene_or_gene_productt+CSSPATH: ROOT >ccomp ++ ROOT >prep_on >vmodt8e1: ents2Label-mention-ngram: knockdown decreases SHAREDtke1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] controlled:Phosphorylationt4e2: trigger-arg-path: inducing >dobj Phosphorylationt+interceding-token ngrams: suppresses serum-t^e2: trigger-arg-path: Positive_regulation dobj Phosphorylationt>e2: trigger-arg-path: inducing nsubj >nn controllertinterceding-token ngrams: on tothe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controllert#interceding-token ngrams: affectingtDe1: trigger-arg-path: decreases:Positive_regulation >dobj controlledt'interceding-token ngrams: show that CLUtve1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controller:Gene_or_gene_productt;e2: args2Role-mention-ngram: CONTROLLER inducing CONTROLLEDt?interceding-tokens-full-span: in PC3 cells without affecting total FAK levels by immunoblot analysis . We have gone on to show that CLU siRNA treatment suppresses serum- andt&interceding-token ngrams: to show thatt?e1: trigger-arg-path: decreases >nsubj >nn Gene_or_gene_productt.interceding-token ngrams: levels by immunoblottBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT siRNA knockdowntbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj controlledt$interceding-token ngrams: FAK levelst interceding-token ngrams: in PC3tge2: trigger-arg-path: inducing:Positive_regulation dobj [lemma='phosphorylation'] controlledtPe1: trigger-arg-path: lemmatizedTrigger=decrease >nsubj >nn Gene_or_gene_productt=e2: ents2Label-mention-ngram: inducing SHARED phosphorylationtIe1: trigger-arg-path: decreases:Positive_regulation >nsubj >nn controllert$interceding-token ngrams: gone on tot&interceding-token ngrams: We have gonethe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_regulation dobj [lemma='phosphorylation'] controlled:Phosphorylationtue1: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] Gene_or_gene_producttBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducing SHAREDtMe2: trigger-arg-path: inducing:Positive_regulation nsubj [lemma='knockdown'] >nn [lemma='CLU'] controllertae1: trigger-arg-path: Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controllert/interceding-token ngrams: suppresses serum- andtAe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj controlledtTe1: trigger-arg-path: decreases:Positive_regulation >dobj controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controller:Gene_or_gene_producttne1: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] controlled:PhosphorylationtSe2: trigger-arg-path: inducing:Positive_regulation >dobj controlled:Phosphorylationt&interceding-token ngrams: have gone ont.interceding-token ngrams: treatment suppressest>e1: ents2Label-mention-ngram: decreases SHARED phosphorylationt$interceding-token ngrams: on to showt`e1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] PhosphorylationtYe2: trigger-arg-path: inducing >dobj [lemma='phosphorylation'] controlled:Phosphorylationt)interceding-token ngrams: affecting totalt#interceding-token ngrams: . We havet^e1: trigger-arg-path: decreases:Positive_regulation >dobj [lemma='phosphorylation'] controlledt;e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inducingt$interceding-token ngrams: serum- andt;e1: args2Role-mention-ngram: knockdown decreases CONTROLLEDt5interceding-token ngrams: treatment suppresses serum-tee1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj controlled:Phosphorylationt1e1: ents2Label-mention-ngram: knockdown decreasest#interceding-token ngrams: PC3 cellstoe1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj [lemma='phosphorylation'] controlledtDe2: trigger-arg-path: inducing dobj [lemma='phosphorylation'] Phosphorylationtme2: trigger-arg-path: inducing:Positive_regulation >dobj [lemma='phosphorylation'] controlled:Phosphorylationtce2: trigger-arg-path: lemmatizedTrigger=induce dobj [lemma='phosphorylation'] controlled:PhosphorylationtJe1: trigger-arg-path: decreases >nsubj >nn controller:Gene_or_gene_producttIe2: trigger-arg-path: inducing >dobj [lemma='phosphorylation'] controlledtinterceding-token ngrams: gonet[e1: trigger-arg-path: lemmatizedTrigger=decrease >dobj [lemma='phosphorylation'] controlledtke1: trigger-arg-path: decreases:Positive_regulation >nsubj [lemma='knockdown'] >nn [lemma='CLU'] controllert7e1: ents2Label-mention-ngram: siRNA knockdown decreasestRe2: trigger-arg-path: inducing:Positive_regulation nsubj >nn controllertZe1: trigger-arg-path: lemmatizedTrigger=decrease:Positive_regulation >dobj PhosphorylationtFe1: trigger-arg-path: lemmatizedTrigger=decrease >dobj Phosphorylationt,e1: args2Role-mention-ngram: siRNA knockdownt-interceding-token ngrams: affecting total FAKthe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_producttAe1: ents2Label-mention-ngram: associate with GENE_OR_GENE_PRODUCTt+interceding-token ngrams: reported that thetBe1: trigger-arg-path: associate >prep_with [lemma='nm23-h1'] themetqe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='nm23-h1'] theme:Gene_or_gene_producttOe1: trigger-arg-path: Binding >prep_with [lemma='nm23-h1'] Gene_or_gene_productt3interceding-token ngrams: scaffold kinase repressortie1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='nm23-h1'] theme:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] themet\e1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='nm23-h1'] themet\e1: trigger-arg-path: associate:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt!interceding-token ngrams: KSR ) [t-interceding-token ngrams: the scaffold kinaset@e1: trigger-arg-path: Binding >prep_with [lemma='nm23-h1'] themetce2: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt)interceding-token ngrams: scaffold kinaset2e1: args2Role-mention-ngram: THEME could associatet$interceding-token ngrams: ) reportedt,interceding-token ngrams: may phosphorylatestQe1: trigger-arg-path: associate >prep_with [lemma='nm23-h1'] Gene_or_gene_productt0interceding-token ngrams: may phosphorylates thet"interceding-token ngrams: of Ras (t interceding-token ngrams: 2002 )tinterceding-token ngrams: , (t)interceding-token ngrams: 2002 ) reportedt#interceding-token ngrams: Gigoux ettVe1: trigger-arg-path: associate:Binding >nsubj [lemma='aurora-a'] Gene_or_gene_productt*interceding-token ngrams: kinase repressortWe2: trigger-arg-path: Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt"interceding-token ngrams: . GigouxtNe2: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] themetinterceding-token ngrams: ) [t%interceding-token ngrams: . Gigoux ett#interceding-token ngrams: which mayt(e1: args2Role-mention-ngram: THEME couldt)interceding-token ngrams: ) reported thattue2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] theme:Gene_or_gene_producttinterceding-token ngrams: ) [ -tme2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] theme:Gene_or_gene_producttUe2: trigger-arg-path: interaction >prep_between [lemma='rasgap'] Gene_or_gene_productt$interceding-token ngrams: ] . GigouxtYe1: trigger-arg-path: associate:Binding >prep_with [lemma='nm23-h1'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='aurora-a'] Gene_or_gene_productt-interceding-token ngrams: kinase repressor oft!interceding-token ngrams: ( KSR )tTe1: trigger-arg-path: associate >nsubj [lemma='aurora-a'] theme:Gene_or_gene_producttWe1: trigger-arg-path: associate >prep_with [lemma='nm23-h1'] theme:Gene_or_gene_producttJe1: trigger-arg-path: associate:Binding >prep_with [lemma='nm23-h1'] themetYe1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='aurora-a'] themet*interceding-token ngrams: repressor of Rastinterceding-token ngrams: ( KSRt2interceding-token ngrams: which may phosphorylatest"interceding-token ngrams: , ( 2002t2e1: ents2Label-mention-ngram: could associate witht_e1: trigger-arg-path: associate:Binding >prep_with [lemma='nm23-h1'] theme:Gene_or_gene_productt,interceding-token ngrams: phosphorylates thet[e2: trigger-arg-path: interaction >prep_between [lemma='rasgap'] theme:Gene_or_gene_productt+CSSPATH: ROOT  ++ ROOT >rcmod >ccomp >nsubjt,e1: args2Role-mention-ngram: could associatet?interceding-tokens-full-span: , which may phosphorylates the scaffold kinase repressor of Ras ( KSR ) [ - ] . Gigoux et al. , ( 2002 ) reported that thetke1: trigger-arg-path: lemmatizedTrigger=associate:Binding >prep_with [lemma='nm23-h1'] Gene_or_gene_productt?e1: trigger-arg-path: associate >nsubj [lemma='aurora-a'] themetinterceding-token ngrams: KSR )tXe2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] themet1e1: args2Role-mention-ngram: could associate witht#interceding-token ngrams: Ras ( KSRt5interceding-token ngrams: phosphorylates the scaffoldt'interceding-token ngrams: Gigoux et al.t"interceding-token ngrams: ( 2002 )t&interceding-token ngrams: the scaffoldtinterceding-token ngrams: 2002tge2: trigger-arg-path: lemmatizedTrigger=interaction >prep_between [lemma='rasgap'] Gene_or_gene_producttFe2: trigger-arg-path: interaction >prep_between [lemma='rasgap'] themetTe1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='nm23-h1'] themetoe2: trigger-arg-path: lemmatizedTrigger=interaction:Binding >prep_between [lemma='rasgap'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=associate >prep_with [lemma='nm23-h1'] Gene_or_gene_productt4e1: ents2Label-mention-ngram: SHARED could associatetne1: trigger-arg-path: lemmatizedTrigger=associate:Binding >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt!interceding-token ngrams: al. , (tNe1: trigger-arg-path: associate >nsubj [lemma='aurora-a'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: could associatet interceding-token ngrams: ( 2002tGe1: trigger-arg-path: associate:Binding >nsubj [lemma='aurora-a'] themet&interceding-token ngrams: repressor oft%interceding-token ngrams: , which maytQe2: trigger-arg-path: Binding >prep_between [lemma='rasgap'] Gene_or_gene_productt]e2: trigger-arg-path: interaction:Binding >prep_between [lemma='rasgap'] Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='aurora-a'] themet interceding-token ngrams: GigouxtUe1: trigger-arg-path: Binding >prep_with [lemma='nm23-h1'] theme:Gene_or_gene_producttBe2: trigger-arg-path: Binding >prep_between [lemma='rasgap'] themetfe1: trigger-arg-path: lemmatizedTrigger=associate >nsubj [lemma='aurora-a'] theme:Gene_or_gene_productt?interceding-tokens-full-span: , which may phosphorylates the scaffold kinase repressor of Ras ( KSR ) [ - ] . Gigoux et al. , ( 2002 ) reported that the interaction betweent$CSSPATH: ROOT  ++ ROOT >rcmod >ccomptNe1: trigger-arg-path: Binding >nsubj [lemma='pp2a'] theme:Gene_or_gene_producttQe2: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] Gene_or_gene_producttinterceding-token ngrams: PP2AtAe1: trigger-arg-path: Binding >prep_with [lemma='aurora-a'] themetie1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pp2a'] theme:Gene_or_gene_producttOe2: trigger-arg-path: complex >nn [lemma='aurora-a'] theme:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_productt#interceding-token ngrams: . Whethertae2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pp2a'] theme:Gene_or_gene_productt"interceding-token ngrams: PP2A maytJe2: trigger-arg-path: Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttJe2: trigger-arg-path: complex >nn [lemma='ksr'] theme:Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='aurora-a'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pp2a'] Gene_or_gene_producttRe1: trigger-arg-path: interacts >prep_with [lemma='aurora-a'] Gene_or_gene_productt;e1: trigger-arg-path: interacts >nsubj [lemma='pp2a'] themetie1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='aurora-a'] theme:Gene_or_gene_productt=interceding-tokens-full-span: . Whether the PP2A may regulatetae1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pp2a'] theme:Gene_or_gene_producttXe1: trigger-arg-path: interacts >prep_with [lemma='aurora-a'] theme:Gene_or_gene_productt:e2: trigger-arg-path: Binding >nn [lemma='aurora-a'] themetPe1: trigger-arg-path: Binding >prep_with [lemma='aurora-a'] Gene_or_gene_productt[e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] Gene_or_gene_producttCe1: trigger-arg-path: interacts >prep_with [lemma='aurora-a'] themet*interceding-token ngrams: Whether the PP2AtIe2: trigger-arg-path: Binding >nn [lemma='aurora-a'] Gene_or_gene_productt%interceding-token ngrams: Whether thetHe1: trigger-arg-path: Binding >nsubj [lemma='pp2a'] Gene_or_gene_producttZe1: trigger-arg-path: interacts:Binding >prep_with [lemma='aurora-a'] Gene_or_gene_productt:e2: trigger-arg-path: complex >nn [lemma='aurora-a'] themetBe2: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] themet`e1: trigger-arg-path: interacts:Binding >prep_with [lemma='aurora-a'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='aurora-a'] Gene_or_gene_productt'interceding-token ngrams: . Whether thetRe2: trigger-arg-path: complex:Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttRe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pp2a'] Gene_or_gene_productt=e2: trigger-arg-path: complex:Binding >nn [lemma='ksr'] themet&interceding-token ngrams: may regulatetOe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] themetIe2: trigger-arg-path: complex >nn [lemma='aurora-a'] Gene_or_gene_producttDe2: trigger-arg-path: complex >nn [lemma='ksr'] Gene_or_gene_productt"interceding-token ngrams: the PP2At#CSSPATH: ROOT  ++ ROOT >csubj >dobjtqe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='aurora-a'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nsubj [lemma='pp2a'] themetCe1: trigger-arg-path: interacts:Binding >nsubj [lemma='pp2a'] themet&interceding-token ngrams: the PP2A maytWe2: trigger-arg-path: complex:Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_productt!interceding-token ngrams: WhethertTe1: trigger-arg-path: lemmatizedTrigger=interact >prep_with [lemma='aurora-a'] themetPe1: trigger-arg-path: interacts >nsubj [lemma='pp2a'] theme:Gene_or_gene_producttDe2: trigger-arg-path: Binding >nn [lemma='ksr'] Gene_or_gene_producttLe1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pp2a'] themetKe1: trigger-arg-path: interacts:Binding >prep_with [lemma='aurora-a'] themet[e1: trigger-arg-path: lemmatizedTrigger=interact >nsubj [lemma='pp2a'] Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] themet5e2: trigger-arg-path: Binding >nn [lemma='ksr'] themetLe2: trigger-arg-path: complex:Binding >nn [lemma='ksr'] Gene_or_gene_producttGe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] themetVe1: trigger-arg-path: Binding >prep_with [lemma='aurora-a'] theme:Gene_or_gene_productt5e2: trigger-arg-path: complex >nn [lemma='ksr'] themet\e1: trigger-arg-path: lemmatizedTrigger=interact:Binding >prep_with [lemma='aurora-a'] themetVe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] Gene_or_gene_producttJe1: trigger-arg-path: interacts >nsubj [lemma='pp2a'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] theme:Gene_or_gene_producttTe1: trigger-arg-path: lemmatizedTrigger=interact:Binding >nsubj [lemma='pp2a'] themet\e2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='ksr'] theme:Gene_or_gene_producttLe2: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='aurora-a'] themetOe2: trigger-arg-path: Binding >nn [lemma='aurora-a'] theme:Gene_or_gene_producttce2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='aurora-a'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='ksr'] Gene_or_gene_productt+interceding-token ngrams: PP2A may regulatetKe2: trigger-arg-path: bound >prep_to [lemma='raf-rbd'] Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] themetQe2: trigger-arg-path: bound >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_productt6e2: trigger-arg-path: bound >nsubj [lemma='ra'] Familyt)e1: trigger-arg-path: bound >nsubj Familytde2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_productt/e1: trigger-arg-path: bound >nsubj theme:Familyt\e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] Gene_or_gene_producttYe1: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] theme:FamilytYe2: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] themet1e1: trigger-arg-path: bound:Binding >nsubj Familyt7e2: trigger-arg-path: bound:Binding >nsubj theme:FamilytMe1: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_producttnsubj [lemma='ra'] theme:Familyt>e1: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] themet5e2: trigger-arg-path: bound >nsubj [lemma='ra'] themetQe1: trigger-arg-path: bound >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_producttMe2: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_productt7e1: trigger-arg-path: bound:Binding >nsubj theme:Familyt=e1: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] themet=e2: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] themet1e2: trigger-arg-path: bound:Binding >nsubj FamilytDe2: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] themetSe2: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_producttSe1: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_producttDe2: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] theme:Familytprep_to [lemma='raf-rbd'] themetbe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_productt>e1: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] Familytje2: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_productt/e2: trigger-arg-path: bound >nsubj theme:Familytnsubj [lemma='ra'] theme:Familytprep_to [lemma='raf-rbd'] themetbe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_productt>e2: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] themetMe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] themet6e1: trigger-arg-path: bound >nsubj [lemma='ra'] Familytje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_productt)e2: trigger-arg-path: bound >nsubj Familyt>e2: trigger-arg-path: bound:Binding >nsubj [lemma='ra'] FamilytUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='raf-rbd'] themetSe1: trigger-arg-path: Binding >prep_to [lemma='raf-rbd'] theme:Gene_or_gene_producttSe2: trigger-arg-path: bound:Binding >prep_to [lemma='raf-rbd'] Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='raf-rbd'] themetKe1: trigger-arg-path: bound >prep_to [lemma='raf-rbd'] Gene_or_gene_productt5e1: trigger-arg-path: bound >nsubj [lemma='ra'] themetTshortest-path: xcomp [lemma='up-regulate'] >dobj [lemma='p21']tYtrigger-to-trigger-path: e1:up-regulate:Positive_regulation >dobj >rcmod e2:binds:Bindingt3e1: ents2Label-mention-ngram: to up-regulate SHAREDt0e1: ents2Label-mention-ngram: up-regulate SHAREDtvtrigger-to-trigger-path: e1:up-regulate:Positive_regulation >dobj [lemma='p21'] >rcmod [lemma='bind'] e2:binds:Bindingt2e1: ents2Label-mention-ngram: up-regulate SHARED ,t"shortest-path: xcomp >dobjtHe1: trigger-arg-path: Binding >nn [lemma='cycline'] Gene_or_gene_producttNe1: trigger-arg-path: Binding >nn [lemma='cycline'] theme:Gene_or_gene_producttKe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] themet9e1: trigger-arg-path: complex >nn [lemma='cycline'] themetNe1: trigger-arg-path: complex >nn [lemma='cycline'] theme:Gene_or_gene_productt$interceding-tokens-full-span: . ThistPe1: trigger-arg-path: complex:Binding >nn [lemma='cycline'] Gene_or_gene_producttSe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] themethe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] theme:Gene_or_gene_productt9e1: trigger-arg-path: Binding >nn [lemma='cycline'] themetVe1: trigger-arg-path: complex:Binding >nn [lemma='cycline'] theme:Gene_or_gene_producttAe1: trigger-arg-path: complex:Binding >nn [lemma='cycline'] themetbe1: trigger-arg-path: lemmatizedTrigger=complex:Binding >nn [lemma='cycline'] Gene_or_gene_producttHe1: trigger-arg-path: complex >nn [lemma='cycline'] Gene_or_gene_productt`e1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] theme:Gene_or_gene_producttZe1: trigger-arg-path: lemmatizedTrigger=complex >nn [lemma='cycline'] Gene_or_gene_productt9CSSPATH: ROOT >xcomp >dobj >rcmod >prep_to ++ ROOT >nsubjt5e1: args2Role-mention-ngram: requires both CONTROLLEDtde1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='jnk'] controller:Gene_or_gene_producttie2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] theme:Gene_or_gene_producttye2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] theme:Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] themet"interceding-token ngrams: active .t:e2: trigger-arg-path: Binding >prep_of [lemma='AKT'] themet6e1: ents2Label-mention-ngram: both phosphorylation andt interceding-token ngrams: becometge2: trigger-arg-path: Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] theme:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] theme:Gene_or_gene_producttie2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] Gene_or_gene_producttOe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='jnk'] controllert;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT requirestWe2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] theme:Gene_or_gene_producttTe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] theme:Gene_or_gene_producttBe2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] themetIe2: trigger-arg-path: Binding >prep_of [lemma='AKT'] Gene_or_gene_producttZe2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] themetce2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] Gene_or_gene_producttHe1: trigger-arg-path: requires >nsubj [lemma='jnk'] Gene_or_gene_producttce1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='jnk'] controllert+e1: ents2Label-mention-ngram: requires bothtRe1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='jnk'] controllert)interceding-token ngrams: become active .tLe2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] themetge1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='jnk'] controller:Gene_or_gene_producttme1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='jnk'] Gene_or_gene_producttSe1: trigger-arg-path: requires >nsubj [lemma='jnk'] controller:Gene_or_gene_productt5e1: args2Role-mention-ngram: CONTROLLER requires bothtxe1: trigger-arg-path: lemmatizedTrigger=require:Positive_regulation >nsubj [lemma='jnk'] controller:Gene_or_gene_producttse2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] Gene_or_gene_productt+interceding-token ngrams: binding to becomet'interceding-token ngrams: become activet*interceding-token ngrams: to become activetYe1: trigger-arg-path: lemmatizedTrigger=require >nsubj [lemma='jnk'] Gene_or_gene_productt>e1: trigger-arg-path: requires >nsubj [lemma='jnk'] controllert\e1: trigger-arg-path: requires:Positive_regulation >nsubj [lemma='jnk'] Gene_or_gene_producttQe2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] Gene_or_gene_productt8interceding-tokens-full-span: binding to become active .t{e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] Gene_or_gene_productt@e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT requires bothtoe2: trigger-arg-path: Binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] theme:Gene_or_gene_producttRe2: trigger-arg-path: Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] themetae2: trigger-arg-path: Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] Gene_or_gene_productt*e1: args2Role-mention-ngram: requires botht[e2: trigger-arg-path: lemmatizedTrigger=binding >prep_of [lemma='AKT'] Gene_or_gene_productt#interceding-token ngrams: to becomet;e1: ents2Label-mention-ngram: requires both phosphorylationtOe2: trigger-arg-path: Binding >prep_of [lemma='AKT'] theme:Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=binding:Binding >prep_of [lemma='AKT'] >prep_to [lemma='jip1'] themetPe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='p70s6k'] controlledtHe2: trigger-arg-path: binding:Binding >poss [lemma='its'] Generic_entitytIe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] themet4interceding-token ngrams: whereas phosphorylation oftTe1: trigger-arg-path: activated:Positive_activation >agent [lemma='mtor'] controllertie2: trigger-arg-path: binding prep_to [lemma='eif4e'] theme:Gene_or_gene_productt\e2: trigger-arg-path: binding:Binding prep_to [lemma='eif4e'] themetoe1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mtor'] Gene_or_gene_producttce2: trigger-arg-path: binding prep_to [lemma='eif4e'] Gene_or_gene_producttinterceding-token ngrams: 4EBPtXe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] theme:Generic_entitytie2: trigger-arg-path: Binding prep_to [lemma='eif4e'] theme:Gene_or_gene_producttoe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='p70s6k'] controlled:Gene_or_gene_producttNe2: trigger-arg-path: binding:Binding >poss [lemma='its'] theme:Generic_entityt7e2: trigger-arg-path: binding >poss [lemma='its'] themet1interceding-token ngrams: whereas phosphorylationtPe1: trigger-arg-path: activated >nsubjpass [lemma='p70s6k'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] Generic_entitytqshortest-path: advcl [lemma='inhibit'] >dobj [lemma='binding'] >poss [lemma='its']tTe2: trigger-arg-path: binding prep_to [lemma='eif4e'] themet_e1: trigger-arg-path: Positive_activation >agent [lemma='mtor'] controller:Gene_or_gene_producttQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] themetne2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='eif4e'] themetee1: trigger-arg-path: Positive_activation >nsubjpass [lemma='p70s6k'] controlled:Gene_or_gene_producttTe2: trigger-arg-path: Binding prep_to [lemma='eif4e'] themetle1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='p70s6k'] controlled:Gene_or_gene_producttQe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mtor'] controllert!interceding-token ngrams: of 4EBPtFinterceding-tokens-full-span: whereas phosphorylation of 4EBP inhibitstke1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='p70s6k'] controlledtue2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='eif4e'] Gene_or_gene_producttRe2: trigger-arg-path: lemmatizedTrigger=binding >poss [lemma='its'] Generic_entitytfe1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mtor'] controller:Gene_or_gene_producttFe2: trigger-arg-path: binding >poss [lemma='its'] theme:Generic_entitytze1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mtor'] controller:Gene_or_gene_producttUe1: trigger-arg-path: activated >agent [lemma='mtor'] controller:Gene_or_gene_producttZe1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='p70s6k'] controlledtZe1: trigger-arg-path: Positive_activation >nsubjpass [lemma='p70s6k'] Gene_or_gene_productt*interceding-token ngrams: of 4EBP inhibitstqe2: trigger-arg-path: binding:Binding prep_to [lemma='eif4e'] theme:Gene_or_gene_producttde1: trigger-arg-path: activated:Positive_activation >nsubjpass [lemma='p70s6k'] Gene_or_gene_producttTe1: trigger-arg-path: Positive_activation >agent [lemma='mtor'] Gene_or_gene_producttae1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='p70s6k'] Gene_or_gene_productt}trigger-to-trigger-path: e1:activated:Positive_activation >advcl [lemma='inhibit'] >dobj [lemma='binding'] e2:binding:Bindingt?e2: trigger-arg-path: binding:Binding >poss [lemma='its'] themetfe2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='eif4e'] themetie1: trigger-arg-path: activated:Positive_activation >agent [lemma='mtor'] controller:Gene_or_gene_productt1interceding-token ngrams: phosphorylation of 4EBPt?e1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='p70s6k'] controlled:Gene_or_gene_producttke2: trigger-arg-path: binding:Binding prep_to [lemma='eif4e'] Gene_or_gene_productt@e1: trigger-arg-path: activated >agent [lemma='mtor'] controllertce2: trigger-arg-path: Binding prep_to [lemma='eif4e'] Gene_or_gene_productt@e2: trigger-arg-path: binding >poss [lemma='its'] Generic_entitytFe1: trigger-arg-path: activated >nsubjpass [lemma='p70s6k'] controlledt}e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='eif4e'] Gene_or_gene_productt,shortest-path: advcl >dobj >posstee1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >agent [lemma='mtor'] controllert?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='eif4e'] theme:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='eif4e'] theme:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=activate:Positive_activation >nsubjpass [lemma='p70s6k'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_activation >agent [lemma='mtor'] controllert'interceding-token ngrams: 4EBP inhibitstJe1: trigger-arg-path: activated >agent [lemma='mtor'] Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >poss [lemma='its'] theme:Generic_entityt[e1: trigger-arg-path: lemmatizedTrigger=activate >agent [lemma='mtor'] Gene_or_gene_producttYtrigger-to-trigger-path: e1:activated:Positive_activation >advcl >dobj e2:binding:BindingtWe1: trigger-arg-path: lemmatizedTrigger=activate >nsubjpass [lemma='p70s6k'] controlledt^e1: trigger-arg-path: activated:Positive_activation >agent [lemma='mtor'] Gene_or_gene_productt[e1: trigger-arg-path: activated >nsubjpass [lemma='p70s6k'] controlled:Gene_or_gene_producttbe2: trigger-arg-path: inhibits >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controllert}e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] Gene_or_gene_producttCe2: trigger-arg-path: inhibits >nsubj >prep_of Gene_or_gene_producttle2: trigger-arg-path: inhibits >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] Gene_or_gene_producttMe2: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of controllert?e2: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controller:Gene_or_gene_producttwe2: trigger-arg-path: Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controller:Gene_or_gene_productt9e2: trigger-arg-path: inhibits >nsubj >prep_of controllert?e2: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] Gene_or_gene_producttve2: trigger-arg-path: inhibits:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controllert0shortest-path: advcl >nsubj >prep_oft~shortest-path: advcl [lemma='inhibit'] >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp']t8interceding-tokens-full-span: whereas phosphorylation oft5e2: ents2Label-mention-ngram: inhibits SHARED bindingtse2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controllert?e2: trigger-arg-path: Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controllertWe2: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of Gene_or_gene_producttwe2: trigger-arg-path: inhibits >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controller:Gene_or_gene_producttrtrigger-to-trigger-path: e1:activated:Positive_activation >advcl [lemma='inhibit'] e2:inhibits:Negative_regulationtBe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibits SHAREDtbe2: trigger-arg-path: inhibits:Negative_regulation >nsubj >prep_of controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] Gene_or_gene_producttme2: trigger-arg-path: Negative_regulation >nsubj [lemma='phosphorylation'] >prep_of [lemma='4ebp'] controllertNe2: trigger-arg-path: inhibits >nsubj >prep_of controller:Gene_or_gene_productt`trigger-to-trigger-path: e1:activated:Positive_activation >advcl e2:inhibits:Negative_regulationt&interceding-token ngrams: is preventedt4e2: ents2Label-mention-ngram: then phosphorylated bytbe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='eif4e'] theme:Gene_or_gene_producttXe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='p70s6k'] controllert\e1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='eif4e'] Gene_or_gene_producttve2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='p70s6k'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: eIF4E which istee2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] PhosphorylationtRe1: trigger-arg-path: bound:Binding >prep_to [lemma='4e-bp1'] Gene_or_gene_producttpe2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] controlled:Phosphorylationt.interceding-token ngrams: upon phosphorylationt+e2: ents2Label-mention-ngram: which is thent0interceding-token ngrams: initiation complex buttXe1: trigger-arg-path: bound:Binding >prep_to [lemma='4e-bp1'] theme:Gene_or_gene_producttde1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='eif4e'] Gene_or_gene_productt3e2: ents2Label-mention-ngram: SHARED releases eIF4Et;e1: trigger-arg-path: bound >prep_to [lemma='4e-bp1'] themetCe1: trigger-arg-path: bound:Binding >prep_to [lemma='4e-bp1'] themet%interceding-token ngrams: complex butt,e2: ents2Label-mention-ngram: releases eIF4EtMe1: trigger-arg-path: Binding >nsubjpass [lemma='eif4e'] Gene_or_gene_producttVe2: trigger-arg-path: Positive_regulation >agent [lemma='p70s6k'] Gene_or_gene_productt0interceding-token ngrams: prevented from joiningtce1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='4e-bp1'] Gene_or_gene_productt+interceding-token ngrams: is prevented fromtnsubjpass [lemma='eif4e'] themet`e2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] controlledtSe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='eif4e'] Gene_or_gene_producttke2: trigger-arg-path: phosphorylated nn [lemma='4e-bp1'] controlled:Phosphorylationt=e1: trigger-arg-path: Binding >prep_to [lemma='4e-bp1'] themet?shortest-path: prepc_from [lemma='join'] >prep_by [lemma='mtor'] >appos [lemma='eif4e'] >nn [lemma='4e-bp1']t[e2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='p70s6k'] controllert)interceding-token ngrams: the translationtMe1: trigger-arg-path: lemmatizedTrigger=bind >nsubjpass [lemma='eif4e'] themet[e2: trigger-arg-path: phosphorylated nn [lemma='4e-bp1'] controlledt!interceding-token ngrams: joiningtje1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='eif4e'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='4e-bp1'] controlledt!interceding-token ngrams: by mTORtLe1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='4e-bp1'] themetTe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='4e-bp1'] themet?trigger-to-trigger-path: e1:bound:Binding prepc_from [lemma='join'] >prep_by [lemma='mtor'] >appos [lemma='eif4e'] >rcmod [lemma='phosphorylate'] e2:phosphorylated:Positive_regulationt4e2: ents2Label-mention-ngram: is then phosphorylatedtSe1: trigger-arg-path: Binding >nsubjpass [lemma='eif4e'] theme:Gene_or_gene_producttUe1: trigger-arg-path: lemmatizedTrigger=bind:Binding >nsubjpass [lemma='eif4e'] themet4interceding-token ngrams: the translation initiationt`e2: trigger-arg-path: phosphorylated nn [lemma='4e-bp1'] Phosphorylationt-e2: ents2Label-mention-ngram: SHARED releasestqe2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='4e-bp1'] Phosphorylationte2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='4e-bp1'] controlled:Phosphorylationt1interceding-token ngrams: phosphorylation by mTORtae1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='4e-bp1'] theme:Gene_or_gene_producttytrigger-to-trigger-path: e1:bound:Binding prepc_from >prep_by >appos >rcmod e2:phosphorylated:Positive_regulationtee2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='p70s6k'] Gene_or_gene_productt*interceding-token ngrams: from joining thet2e2: ents2Label-mention-ngram: releases eIF4E whicht1interceding-token ngrams: joining the translationt[e1: trigger-arg-path: lemmatizedTrigger=bind >prep_to [lemma='4e-bp1'] Gene_or_gene_productt"interceding-token ngrams: but upont?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='4e-bp1'] PhosphorylationtRe1: trigger-arg-path: Binding >prep_to [lemma='4e-bp1'] theme:Gene_or_gene_producttDe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='eif4e'] themet?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='p70s6k'] controller:Gene_or_gene_producttte2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='4e-bp1'] Phosphorylationt?e2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation nn [lemma='4e-bp1'] controlled:PhosphorylationtYe1: trigger-arg-path: bound:Binding >nsubjpass [lemma='eif4e'] theme:Gene_or_gene_producttQe2: trigger-arg-path: phosphorylated >agent [lemma='p70s6k'] Gene_or_gene_productt(interceding-token ngrams: prevented fromtGe2: trigger-arg-path: phosphorylated >agent [lemma='p70s6k'] controllert0interceding-token ngrams: translation initiationt1e2: ents2Label-mention-ngram: then phosphorylatedt#e2: ents2Label-mention-ngram: eIF4EtKe1: trigger-arg-path: bound >nsubjpass [lemma='eif4e'] Gene_or_gene_producttPe1: trigger-arg-path: bound >prep_to [lemma='4e-bp1'] theme:Gene_or_gene_productt2interceding-token ngrams: but upon phosphorylationtle2: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='p70s6k'] controllert&e2: ents2Label-mention-ngram: releasestLe1: trigger-arg-path: Binding >prep_to [lemma='4e-bp1'] Gene_or_gene_productt\e2: trigger-arg-path: phosphorylated >agent [lemma='p70s6k'] controller:Gene_or_gene_producttae2: trigger-arg-path: Positive_regulation >agent [lemma='p70s6k'] controller:Gene_or_gene_producttie1: trigger-arg-path: lemmatizedTrigger=bind:Binding >prep_to [lemma='4e-bp1'] theme:Gene_or_gene_productt)interceding-token ngrams: it is preventedt>e1: trigger-arg-path: Binding >nsubjpass [lemma='eif4e'] themet1interceding-token ngrams: upon phosphorylation byt#interceding-token ngrams: by mTOR ,tbe2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='p70s6k'] Gene_or_gene_productt%interceding-token ngrams: translationt*interceding-token ngrams: complex but upontme2: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='p70s6k'] controller:Gene_or_gene_productt8interceding-token ngrams: translation initiation complextpe2: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='p70s6k'] controller:Gene_or_gene_producttQe1: trigger-arg-path: bound >nsubjpass [lemma='eif4e'] theme:Gene_or_gene_producttLe2: trigger-arg-path: Positive_regulation >agent [lemma='p70s6k'] controllert|e2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='4e-bp1'] controlled:Phosphorylationt?interceding-tokens-full-span: it is prevented from joining the translation initiation complex but upon phosphorylation by mTOR ,t%interceding-token ngrams: joining thet)e2: ents2Label-mention-ngram: eIF4E whichtle2: trigger-arg-path: lemmatizedTrigger=phosphorylate nn [lemma='4e-bp1'] controlledtoe2: trigger-arg-path: phosphorylated:Positive_regulation nn [lemma='4e-bp1'] controlledt;e1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT is boundt@shortest-path: prepc_from >prep_by >appos >nnt interceding-token ngrams: mTOR ,tJe1: trigger-arg-path: bound >prep_to [lemma='4e-bp1'] Gene_or_gene_productt&interceding-token ngrams: from joiningtVe2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn controllert0e2: args2Role-mention-ngram: CONTROLLER releasestUe2: trigger-arg-path: releases:Positive_regulation nn controllertce2: trigger-arg-path: lemmatizedTrigger=release nn [lemma='4e-bp1'] controllertxe2: trigger-arg-path: lemmatizedTrigger=release nn [lemma='4e-bp1'] controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn controller:Gene_or_gene_producttAe2: trigger-arg-path: releases nn [lemma='4e-bp1'] Gene_or_gene_producttre2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] controller:Gene_or_gene_producttFe2: trigger-arg-path: releases nn controller:Gene_or_gene_producttOe2: trigger-arg-path: releases:Positive_regulation nn Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn [lemma='4e-bp1'] Gene_or_gene_productt*e2: ents2Label-mention-ngram: SHARED whicht>e2: trigger-arg-path: lemmatizedTrigger=release nn controllert-e2: ents2Label-mention-ngram: SHARED which ist=e2: trigger-arg-path: releases nn [lemma='4e-bp1'] controllertLe2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] controllert?e2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn [lemma='4e-bp1'] Gene_or_gene_producttJe2: trigger-arg-path: releases:Positive_regulation nn controller:Gene_or_gene_producttEe2: trigger-arg-path: releases:Positive_regulation nn controllertpe2: trigger-arg-path: releases:Positive_regulation nn [lemma='4e-bp1'] Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=release:Positive_regulation nn [lemma='4e-bp1'] controller:Gene_or_gene_productt%e2: args2Role-mention-ngram: releasestptrigger-to-trigger-path: e1:bound:Binding prepc_from >prep_by >appos >nn e2:releases:Positive_regulationt0e2: args2Role-mention-ngram: releases CONTROLLEDt6e2: trigger-arg-path: releases nn [lemma='4e-bp1'] controllertLe2: trigger-arg-path: lemmatizedTrigger=release nn Gene_or_gene_producttNe2: trigger-arg-path: lemmatizedTrigger=release prepc_from [lemma='join'] >prep_by [lemma='mtor'] >appos [lemma='eif4e'] >nn [lemma='release'] e2:releases:Positive_regulationt\e2: trigger-arg-path: releases nn [lemma='4e-bp1'] Gene_or_gene_productt;e2: trigger-arg-path: releases nn Gene_or_gene_producttZe2: trigger-arg-path: releases:Positive_regulation nn controller:Gene_or_gene_productte2: trigger: releasestGe2: trigger-arg-path: lemmatizedTrigger=release nn [lemma='4e-bp1'] controllert-e2: ents2Label-mention-ngram: releases SHAREDt3e2: ents2Label-mention-ngram: releases SHARED whichtHe2: trigger-arg-path: Positive_regulation nn [lemma='4e-bp1'] controller:Gene_or_gene_producttge2: trigger-arg-path: releases nn [lemma='4e-bp1'] controller:Gene_or_gene_producttQe2: trigger-arg-path: Positive_regulation prep_by [lemma='p70s6k'] controllert3e2: ents2Label-mention-ngram: turn , phosphorylatedt'shortest-path: agent >appostGe2: trigger-arg-path: Negative_regulation appos Phosphorylationtke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='eef2'] controllertAe1: ents2Label-mention-ngram: inactivated by GENE_OR_GENE_PRODUCTthe2: trigger-arg-path: Negative_regulation appos [lemma='eef2k'] Phosphorylationt,e1: args2Role-mention-ngram: and inactivatedt?e1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controller:Gene_or_gene_producttae2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by [lemma='p70s6k'] Gene_or_gene_productt_e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos controlledtNe2: trigger-arg-path: inactivated:Negative_regulation appos controlledtIe2: trigger-arg-path: inactivated:Negative_regulation >prep_by controllertotrigger-to-trigger-path: e1:phosphorylated:Positive_regulation >agent >rcmod e2:inactivated:Negative_regulationtte1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controller:Gene_or_gene_producttXe2: trigger-arg-path: Negative_regulation >prep_by [lemma='p70s6k'] Gene_or_gene_producttZe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by controllert(e2: ents2Label-mention-ngram: ) which istce2: trigger-arg-path: Negative_regulation appos [lemma='eef2k'] controlledt[e2: trigger-arg-path: lemmatizedTrigger=inactivate appos controlled:Phosphorylationt?e2: trigger-arg-path: inactivated >prep_by Gene_or_gene_producttBe2: trigger-arg-path: Negative_regulation appos controlledt"e2: ents2Label-mention-ngram: is ,txe1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] Gene_or_gene_productt(e1: args2Role-mention-ngram: inactivatedtAe2: ents2Label-mention-ngram: inactivated by GENE_OR_GENE_PRODUCTtZe1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='eef2'] controllertDe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT is phosphorylatedt[e2: trigger-arg-path: inactivated appos [lemma='eef2k'] controlledtFe2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by controllertde2: trigger-arg-path: inactivated:Negative_regulation >prep_by [lemma='p70s6k'] Gene_or_gene_productt%e2: ents2Label-mention-ngram: is , int+e1: args2Role-mention-ngram: inactivated bytke2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by [lemma='p70s6k'] controllertde2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos [lemma='eef2k'] controlled:Phosphorylationt?e2: trigger-arg-path: inactivated appos Phosphorylationtne1: trigger-arg-path: phosphorylated:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controllertse2: trigger-arg-path: Negative_regulation appos [lemma='eef2k'] controlled:Phosphorylationtle2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by [lemma='p70s6k'] controller:Gene_or_gene_producttue1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='eef2'] Gene_or_gene_producttagent [lemma='kinase'] >appos [lemma='eef2k']tKe2: trigger-arg-path: lemmatizedTrigger=inactivate appos controlledtSe2: trigger-arg-path: inactivated:Negative_regulation >prep_by Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by [lemma='p70s6k'] controllert6e1: args2Role-mention-ngram: inactivated by CONTROLLERtue2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by [lemma='p70s6k'] Gene_or_gene_productt:e2: trigger-arg-path: inactivated appos controlledt0e1: ents2Label-mention-ngram: phosphorylated andtde1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='eef2'] Gene_or_gene_productt-e1: ents2Label-mention-ngram: and inactivatedt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controller:Gene_or_gene_producttie1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] Gene_or_gene_producttoe1: trigger-arg-path: phosphorylated >agent [lemma='kinase'] >nn [lemma='eef2'] controller:Gene_or_gene_producttRe2: trigger-arg-path: Negative_regulation appos controlled:Phosphorylationtoe2: trigger-arg-path: inactivated:Negative_regulation >prep_by [lemma='p70s6k'] controller:Gene_or_gene_productt2e2: ents2Label-mention-ngram: , phosphorylated andtFe2: trigger-arg-path: inactivated >prep_by [lemma='p70s6k'] controllert?trigger-to-trigger-path: e1:phosphorylated:Positive_regulation >agent [lemma='kinase'] >rcmod [lemma='inactivate'] e2:inactivated:Negative_regulationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] Gene_or_gene_productt^e2: trigger-arg-path: inactivated:Negative_regulation >prep_by controller:Gene_or_gene_productt^e2: trigger-arg-path: inactivated:Negative_regulation appos controlled:PhosphorylationtJe2: trigger-arg-path: inactivated >prep_by controller:Gene_or_gene_producttPe2: trigger-arg-path: inactivated >prep_by [lemma='p70s6k'] Gene_or_gene_producttde2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos Phosphorylationte2: trigger-arg-path: inactivated:Negative_regulation appos [lemma='eef2k'] controlled:Phosphorylationt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >agent [lemma='kinase'] >nn [lemma='eef2'] controller:Gene_or_gene_producttPe2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by Gene_or_gene_producttJe2: trigger-arg-path: inactivated appos controlled:Phosphorylationte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controllert7e2: args2Role-mention-ngram: CONTROLLED and inactivatedt_e1: trigger-arg-path: Positive_regulation >agent [lemma='kinase'] >nn [lemma='eef2'] controllert?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos [lemma='eef2k'] Phosphorylationte2: trigger: inactivatedt6e2: args2Role-mention-ngram: inactivated by CONTROLLERt/e1: args2Role-mention-ngram: and inactivated bytle2: trigger-arg-path: lemmatizedTrigger=inactivate appos [lemma='eef2k'] controlledt,e1: ents2Label-mention-ngram: inactivated bytke2: trigger-arg-path: inactivated appos [lemma='eef2k'] controlled:Phosphorylationt.e2: ents2Label-mention-ngram: , phosphorylatedt?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by [lemma='p70s6k'] controller:Gene_or_gene_producttoe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation >prep_by controller:Gene_or_gene_producttte2: trigger-arg-path: inactivated:Negative_regulation appos [lemma='eef2k'] Phosphorylationt(e2: ents2Label-mention-ngram: which is ,t3e1: ents2Label-mention-ngram: is phosphorylated andtoe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos controlled:PhosphorylationtSe2: trigger-arg-path: inactivated:Negative_regulation appos Phosphorylationt7e1: args2Role-mention-ngram: CONTROLLED and inactivatedtZe2: trigger-arg-path: inactivated:Negative_regulation >prep_by [lemma='p70s6k'] controllertce2: trigger-arg-path: Negative_regulation >prep_by [lemma='p70s6k'] controller:Gene_or_gene_producttoe2: trigger-arg-path: inactivated:Negative_regulation appos [lemma='eef2k'] controlledt&interceding-tokens-full-span: kinase (t5e2: trigger-arg-path: inactivated >prep_by controllert?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation appos [lemma='eef2k'] controlledt`e2: trigger-arg-path: inactivated appos [lemma='eef2k'] Phosphorylationt0e1: ents2Label-mention-ngram: and inactivated bytPe2: trigger-arg-path: lemmatizedTrigger=inactivate appos Phosphorylationt0e2: ents2Label-mention-ngram: phosphorylated andt[e2: trigger-arg-path: lemmatizedTrigger=inactivate >prep_by controller:Gene_or_gene_productt|e2: trigger-arg-path: lemmatizedTrigger=inactivate appos [lemma='eef2k'] controlled:Phosphorylationtqe2: trigger-arg-path: lemmatizedTrigger=inactivate appos [lemma='eef2k'] Phosphorylationt[e2: trigger-arg-path: inactivated >prep_by [lemma='p70s6k'] controller:Gene_or_gene_producttQe2: trigger-arg-path: inactivates:Negative_regulation nsubj controlledtke1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='camk'] controller:Gene_or_gene_producttue2: trigger-arg-path: Negative_regulation nsubj [lemma='camk'] Positive_regulationtse2: trigger-arg-path: lemmatizedTrigger=inactivate dobj [lemma='p27'] controllert?e2: trigger-arg-path: inactivates:Negative_regulation dobj [lemma='p27'] controller:Gene_or_gene_producttle2: trigger-arg-path: Negative_regulation nsubj [lemma='camk'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj [lemma='p27'] Gene_or_gene_producttEe2: trigger-arg-path: Negative_regulation nsubj controlledtZe2: trigger-arg-path: inactivates:Negative_regulation nsubj Positive_regulationtWe2: trigger-arg-path: lemmatizedTrigger=inactivate dobj Gene_or_gene_producttYe2: trigger-arg-path: Negative_regulation nsubj controlled:Positive_regulationt`e1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='camk'] Gene_or_gene_productt7e2: args2Role-mention-ngram: and inactivates CONTROLLERtFe2: trigger-arg-path: inactivates nsubj Positive_regulationtnsubj [lemma='camk'] Positive_regulationtQe2: trigger-arg-path: inactivates dobj controller:Gene_or_gene_producttxe2: trigger-arg-path: inactivates nsubj [lemma='camk'] controlled:Positive_regulationtke2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj Positive_regulationt/e2: args2Role-mention-ngram: ERK phosphorylatestEe1: trigger-arg-path: phosphorylates >nsubj [lemma='camk'] controllertve2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj controller:Gene_or_gene_producttZe1: trigger-arg-path: phosphorylates >nsubj [lemma='camk'] controller:Gene_or_gene_productt?e2: trigger-arg-path: inactivates:Negative_regulation dobj [lemma='p27'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj [lemma='camk'] controlledtTe1: trigger-arg-path: Positive_regulation >nsubj [lemma='camk'] Gene_or_gene_producttJe1: trigger-arg-path: Positive_regulation >nsubj [lemma='camk'] controllert%e2: ents2Label-mention-ngram: and ERKt3e2: args2Role-mention-ngram: ERK phosphorylates andtne1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='camk'] controller:Gene_or_gene_producttOe1: trigger-arg-path: phosphorylates >nsubj [lemma='camk'] Gene_or_gene_producttde2: trigger-arg-path: inactivates nsubj [lemma='camk'] controlledtQe2: trigger-arg-path: inactivates nsubj controlled:Positive_regulationtme2: trigger-arg-path: inactivates nsubj [lemma='camk'] Positive_regulationtDe2: trigger-arg-path: Negative_regulation dobj controllert?trigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and [lemma='inactivate'] e2:inactivates:Negative_regulationt3e2: args2Role-mention-ngram: and ERK phosphorylatest=e2: trigger-arg-path: inactivates nsubj controlledte2: trigger-arg-path: Negative_regulation dobj [lemma='p27'] controller:Gene_or_gene_producttWe2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj Positive_regulationtdobj controllertbe2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj controlledtve2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj controlled:Positive_regulationt0e2: ents2Label-mention-ngram: ERK phosphorylatestNe2: trigger-arg-path: Negative_regulation dobj Gene_or_gene_producttxe2: trigger-arg-path: inactivates:Negative_regulation nsubj [lemma='camk'] controlledt>e2: ents2Label-mention-ngram: inactivates GENE_OR_GENE_PRODUCTtje2: trigger-arg-path: Negative_regulation dobj [lemma='p27'] controllert?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj [lemma='p27'] controllertbe2: trigger-arg-path: lemmatizedTrigger=inactivate dobj controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inactivate dobj [lemma='p27'] controller:Gene_or_gene_productt~e2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj [lemma='camk'] Positive_regulationtNe2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj controlledtMe2: trigger-arg-path: lemmatizedTrigger=inactivate dobj controllertPe2: trigger-arg-path: inactivates:Negative_regulation dobj controllert?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj [lemma='camk'] Positive_regulationtbe2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj controlled:Positive_regulationtue2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj [lemma='camk'] controlledtbe2: trigger-arg-path: inactivates dobj [lemma='p27'] controllertte2: trigger-arg-path: Negative_regulation dobj [lemma='p27'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: activates SHARED ,t?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation nsubj [lemma='camk'] controlled:Positive_regulationtNe2: trigger-arg-path: Negative_regulation nsubj Positive_regulationtVe1: trigger-arg-path: lemmatizedTrigger=phosphorylate >nsubj [lemma='camk'] controllertle2: trigger-arg-path: inactivates dobj [lemma='p27'] Gene_or_gene_producttee2: trigger-arg-path: inactivates:Negative_regulation dobj controller:Gene_or_gene_productt$e2: args2Role-mention-ngram: and ERKt?e2: trigger-arg-path: inactivates:Negative_regulation nsubj [lemma='camk'] controlled:Positive_regulationt'e2: ents2Label-mention-ngram: , and ERKtve2: trigger-arg-path: inactivates:Negative_regulation dobj [lemma='p27'] controllert7e1: ents2Label-mention-ngram: SHARED phosphorylates andtwe2: trigger-arg-path: inactivates dobj [lemma='p27'] controller:Gene_or_gene_producttee2: trigger-arg-path: inactivates:Negative_regulation nsubj controlled:Positive_regulationtktrigger-to-trigger-path: e1:phosphorylates:Positive_regulation >conj_and e2:inactivates:Negative_regulationt?e2: trigger-arg-path: Negative_regulation nsubj [lemma='camk'] controlled:Positive_regulationt4e2: ents2Label-mention-ngram: ERK phosphorylates andtYe2: trigger-arg-path: Negative_regulation dobj controller:Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='camk'] Gene_or_gene_producttBe2: ents2Label-mention-ngram: and inactivates GENE_OR_GENE_PRODUCTtZe2: trigger-arg-path: inactivates:Negative_regulation dobj Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='camk'] controllertYe1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='camk'] controllert3e2: args2Role-mention-ngram: inactivates CONTROLLERt4e2: ents2Label-mention-ngram: and ERK phosphorylatestae2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj controllert?e2: trigger-arg-path: lemmatizedTrigger=inactivate nsubj [lemma='camk'] controlled:Positive_regulationt}e2: trigger-arg-path: lemmatizedTrigger=inactivate dobj [lemma='p27'] Gene_or_gene_producttFe2: trigger-arg-path: inactivates dobj Gene_or_gene_productte1: trigger-arg-path: lemmatizedTrigger=phosphorylate:Positive_regulation >nsubj [lemma='camk'] controller:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj [lemma='p27'] controller:Gene_or_gene_productt_e1: trigger-arg-path: Positive_regulation >nsubj [lemma='camk'] controller:Gene_or_gene_productt;e2: args2Role-mention-ngram: phosphorylates and inactivatest&e2: args2Role-mention-ngram: , and ERKtce1: trigger-arg-path: phosphorylates:Positive_regulation >nsubj [lemma='camk'] Gene_or_gene_producttke2: trigger-arg-path: lemmatizedTrigger=inactivate:Negative_regulation dobj Gene_or_gene_productt&interceding-token ngrams: as Bcl-2 andt*interceding-token ngrams: death receptor 't%interceding-token ngrams: Fas , Fas-Lt4interceding-token ngrams: of anti-apoptotic proteinst!interceding-token ngrams: , Fas-Lt)interceding-token ngrams: Caspase-1 , andt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] Gene_or_gene_producttinterceding-token ngrams: 'te1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controller:Gene_or_gene_productt.interceding-token ngrams: pro-apoptotic role ,t)interceding-token ngrams: and Caspase-1 ,t*interceding-token ngrams: Bcl-2 and Bcl-xLt1interceding-token ngrams: nuclear translocation ,tinterceding-token ngrams: the 'tinterceding-token ngrams: Fas ,t(interceding-token ngrams: the repressiont"interceding-token ngrams: as Fas ,t"interceding-token ngrams: ligand ,t}e1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] Gene_or_gene_productt"interceding-token ngrams: , the upt%interceding-token ngrams: Bcl-xL . Int,interceding-token ngrams: pro-apoptotic rolet!interceding-token ngrams: keepingt2interceding-token ngrams: to nuclear translocationt%interceding-token ngrams: Fas-L ( thet6interceding-token ngrams: anti-apoptotic proteins sucht*interceding-token ngrams: of pro-apoptotict?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controller:Gene_or_gene_productt!interceding-token ngrams: ' deathtoe1: trigger-arg-path: Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] Gene_or_gene_productt+interceding-token ngrams: the up regulationt(interceding-token ngrams: receptor ' andt'interceding-token ngrams: and Caspase-1t5interceding-token ngrams: regulation of pro-apoptotict(interceding-token ngrams: or MAPKs leadstae1: trigger-arg-path: phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controllert%interceding-token ngrams: Caspase-1 ,t*interceding-token ngrams: ' death receptort%interceding-token ngrams: such as Fast interceding-token ngrams: as Fast*interceding-token ngrams: leads to nucleart,interceding-token ngrams: respectively ) andt)interceding-token ngrams: translocation ,t(interceding-token ngrams: keeping with at.interceding-token ngrams: with a pro-apoptotict%interceding-token ngrams: the ' deatht&interceding-token ngrams: . In keepingt)interceding-token ngrams: In keeping witht interceding-token ngrams: the upt(interceding-token ngrams: and its ligandt%interceding-token ngrams: MAPKs leadst$interceding-token ngrams: to nucleartke1: trigger-arg-path: phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] Gene_or_gene_productt*interceding-token ngrams: proteins such astse1: trigger-arg-path: lemmatizedTrigger=phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controllertze1: trigger-arg-path: Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controller:Gene_or_gene_producttee1: trigger-arg-path: Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controllert$interceding-token ngrams: In keepingt6interceding-token ngrams: repression of anti-apoptotict"interceding-token ngrams: Bcl-xL .t.interceding-token ngrams: a pro-apoptotic roletinterceding-token ngrams: Fast"interceding-token ngrams: or MAPKst?e1: trigger-arg-path: lemmatizedTrigger=phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controllert'interceding-token ngrams: genes such ast"interceding-token ngrams: as Bcl-2t&interceding-token ngrams: and Bcl-xL .tve1: trigger-arg-path: phosphorylation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controller:Gene_or_gene_productt!interceding-token ngrams: Fas-L (tinterceding-token ngrams: Fas-Ltinterceding-token ngrams: MAPKst$interceding-token ngrams: its ligandt(interceding-token ngrams: death receptort0interceding-token ngrams: of pro-apoptotic genest$interceding-token ngrams: receptor 't/interceding-token ngrams: ligand , respectivelyt)interceding-token ngrams: ) and Caspase-1t/interceding-token ngrams: nuclear translocationt=interceding-tokens-full-span: or MAPKs leads to nuclear translocation , the up regulation of pro-apoptotic genes such as Fas , Fas-L ( the ' death receptor ' and its ligand , respectively ) and Caspase-1 , and the repression of anti-apoptotic proteins such as Bcl-2 and Bcl-xL . In keeping with a pro-apoptotic role ,t interceding-token ngrams: role ,t$interceding-token ngrams: and Bcl-xLtue1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controllert#interceding-token ngrams: , Fas-L (tinterceding-token ngrams: ' andt2interceding-token ngrams: pro-apoptotic genes sucht!interceding-token ngrams: ( the 't#interceding-token ngrams: ' and itst$interceding-token ngrams: genes sucht'interceding-token ngrams: proteins sucht(interceding-token ngrams: MAPKs leads tot&interceding-token ngrams: keeping witht1interceding-token ngrams: anti-apoptotic proteinst-interceding-token ngrams: translocation , thet-interceding-token ngrams: pro-apoptotic genest?e1: trigger-arg-path: phosphorylation:Positive_regulation >prep_of [lemma='stat-1'] >prep_by [lemma='jak'] controller:Gene_or_gene_productt(interceding-token ngrams: respectively )t#interceding-token ngrams: Caspase-1t'interceding-token ngrams: such as Bcl-2t,interceding-token ngrams: and the repressiont*interceding-token ngrams: , respectively )t+interceding-token ngrams: the repression oft&interceding-token ngrams: its ligand ,tEe1: ents2Label-mention-ngram: suppressed GENE_OR_GENE_PRODUCT inducedtRe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT suppressed GENE_OR_GENE_PRODUCTt1CSSPATH: ROOT >ccomp ++ ROOT >ccomp >ccomp >ccompt=e1: ents2Label-mention-ngram: suppressed GENE_OR_GENE_PRODUCTt6CSSPATH: ROOT >ccomp >ccomp ++ ROOT >advcl >dobj >vmodt+interceding-token ngrams: of screening witht?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] themet*e2: args2Role-mention-ngram: inhibited EGFt5e2: args2Role-mention-ngram: CONTROLLER inhibited EGFt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_producttne2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controllert+interceding-token ngrams: During the coursetQe1: trigger-arg-path: binding prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controller:Gene_or_gene_producttre2: trigger-arg-path: inhibited:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controllert2interceding-token ngrams: siRNA mediated knockdownt.interceding-token ngrams: screening with siRNAt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_productthe2: trigger-arg-path: Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controllertie2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp >dobj >nn Gene_or_gene_producttNe2: trigger-arg-path: inhibited:Positive_activation >nsubj >prep_of controllerthe2: trigger-arg-path: inhibited >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] Gene_or_gene_productt#interceding-token ngrams: course oft(interceding-token ngrams: that knockdowntde2: trigger-arg-path: inhibited:Positive_activation >ccomp >dobj >nn controlled:Gene_or_gene_producttVe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themet?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] Gene_or_gene_productt?e1: trigger-arg-path: binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt+e2: ents2Label-mention-ngram: inhibited EGFt2e2: args2Role-mention-ngram: inhibited EGF inducedt?e2: trigger-arg-path: inhibited >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_producttYe1: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_productthe2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj >prep_of Gene_or_gene_productt|e2: trigger-arg-path: inhibited:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] Gene_or_gene_productt+interceding-token ngrams: that knockdown oftze2: trigger-arg-path: inhibited >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_productt]e1: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp >dobj >nn Gene_or_gene_producttQe1: trigger-arg-path: Binding prep_to theme:Gene_or_gene_producttse2: trigger-arg-path: inhibited >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controller:Gene_or_gene_producttre2: trigger-arg-path: Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] Gene_or_gene_productt-interceding-token ngrams: course of screeningt.interceding-token ngrams: found that knockdownte1: trigger-arg-path: Binding prep_to [lemma='raf1'] Gene_or_gene_producttEe2: trigger-arg-path: inhibited >ccomp >dobj >nn Gene_or_gene_producttEe2: trigger-arg-path: Positive_activation >ccomp >dobj >nn controlledt`e2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp >dobj >nn controlled:Gene_or_gene_productt&interceding-token ngrams: of screeningt/interceding-token ngrams: knockdown of scaffoldtICSSPATH: ROOT >xcomp >dobj >prep_of >rcmod >dobj >prep_for ++ ROOT >ccompt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controller:Gene_or_gene_producttprep_to themete1: trigger-arg-path: binding prep_to [lemma='raf1'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj >prep_of controllert'interceding-token ngrams: proteins , wetYe2: trigger-arg-path: inhibited:Positive_activation >ccomp >dobj >nn Gene_or_gene_producttpe1: trigger-arg-path: Binding prep_to [lemma='raf1'] themet}e2: trigger-arg-path: Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controller:Gene_or_gene_producttxe1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] themetPe2: trigger-arg-path: inhibited >ccomp >dobj >nn controlled:Gene_or_gene_productt^e2: trigger-arg-path: inhibited >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controllertOe2: trigger-arg-path: inhibited:Positive_activation >ccomp >dobj >nn controlledtce1: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: inhibited:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_productt?e1: trigger-arg-path: Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttke1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt?interceding-tokens-full-span: . During the course of screening with siRNA mediated knockdown of scaffold proteins , we found that knockdown oft%interceding-token ngrams: of scaffoldtpe2: trigger-arg-path: inhibited >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlledt$interceding-token ngrams: the courset3e2: ents2Label-mention-ngram: inhibited EGF inducedt?e1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt'interceding-token ngrams: the course oftNe1: trigger-arg-path: lemmatizedTrigger=binding prep_to themet_e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp >dobj >nn controlledtKe2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp >dobj >nn controlledtpe1: trigger-arg-path: binding prep_to [lemma='raf1'] themet?e1: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt(interceding-token ngrams: screening withtze2: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlledtse2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj >prep_of controller:Gene_or_gene_producttprep_to themet-interceding-token ngrams: scaffold proteins ,t.interceding-token ngrams: of scaffold proteinstxe2: trigger-arg-path: lemmatizedTrigger=inhibit >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] Gene_or_gene_productt(interceding-token ngrams: siRNA mediatedt?e2: trigger-arg-path: inhibited:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt;e2: trigger-arg-path: inhibited >ccomp >dobj >nn controlledt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controllert@e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibited EGFt+interceding-token ngrams: scaffold proteinst-interceding-token ngrams: with siRNA mediatedtee1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_producttSe1: trigger-arg-path: binding:Binding prep_to Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlledt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] themette2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp >dobj >nn controlled:Gene_or_gene_producttDe1: trigger-arg-path: binding:Binding prep_to themet?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] Gene_or_gene_productt#interceding-token ngrams: screeningtKe1: trigger-arg-path: Binding prep_to Gene_or_gene_productt interceding-token ngrams: courset?e1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt&interceding-token ngrams: . During thetKe1: trigger-arg-path: binding prep_to Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: inhibited:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_producttZe2: trigger-arg-path: Positive_activation >ccomp >dobj >nn controlled:Gene_or_gene_productt?e2: trigger-arg-path: Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=inhibit:Positive_activation >ccomp [lemma='induce'] >dobj [lemma='activation'] >nn [lemma='raf1'] controlledtXe2: trigger-arg-path: inhibited:Positive_activation >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: inhibited:Positive_activation >nsubj [lemma='knockdown'] >prep_of [lemma='shoc2'] controller:Gene_or_gene_productt$interceding-token ngrams: During thetce2: trigger-arg-path: inhibited:Positive_activation >nsubj >prep_of controller:Gene_or_gene_productt$interceding-token ngrams: with siRNAtOe2: trigger-arg-path: Positive_activation >ccomp >dobj >nn Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] controllert?interceding-tokens-full-span: . During the course of screening with siRNA mediated knockdown of scaffold proteins , we found that knockdown of Shoc2 inhibitedt`e2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_producttle2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_producttwe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt,interceding-token ngrams: knockdown of Shoc2t|e2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_producttqe2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_producttle2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] Gene_or_gene_producttSe2: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] Gene_or_gene_producttbe2: trigger-arg-path: Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlledt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_producttwe2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_producttIe2: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] controllerte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt)interceding-token ngrams: Shoc2 inhibitedt"interceding-token ngrams: of Shoc2tke2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlled:Gene_or_gene_producttge2: trigger-arg-path: lemmatizedTrigger=induce >dobj [lemma='activation'] >nn [lemma='raf1'] controlledtfe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_productt{e2: trigger-arg-path: lemmatizedTrigger=induce:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlledt,interceding-token ngrams: of Shoc2 inhibitedtQe2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] controllertje2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] controlledtPCSSPATH: ROOT >xcomp >dobj >prep_of >rcmod >dobj >prep_for ++ ROOT >ccomp >ccompt^e2: trigger-arg-path: Positive_activation >nsubj [lemma='egf'] controller:Gene_or_gene_productt[e2: trigger-arg-path: induced:Positive_activation >nsubj [lemma='egf'] Gene_or_gene_producttVe2: trigger-arg-path: induced >dobj [lemma='activation'] >nn [lemma='raf1'] controlledtinterceding-token ngrams: Shoc2tte2: trigger-arg-path: induced:Positive_activation >dobj [lemma='activation'] >nn [lemma='raf1'] Gene_or_gene_productt2shortest-path: conj_and >dobj >prep_of >nntje2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Gene_or_gene_producttUe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to themetPe2: trigger-arg-path: binding prep_to theme:Gene_or_gene_productt;e2: trigger-arg-path: binding prep_to themet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttre2: trigger-arg-path: binding prep_to [lemma='raf1'] themetde2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Gene_or_gene_producttMe2: trigger-arg-path: lemmatizedTrigger=binding prep_to themetetrigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and >dobj >prep_of e2:binding:Bindingt/interceding-token ngrams: calmodulin inhibitiontre2: trigger-arg-path: Binding prep_to [lemma='raf1'] themet?trigger-to-trigger-path: e1:inhibited:Negative_regulation >conj_and [lemma='suppress'] >dobj [lemma='inhibition'] >prep_of [lemma='binding'] e2:binding:Bindingt?e2: trigger-arg-path: Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt?shortest-path: conj_and [lemma='suppress'] >dobj [lemma='inhibition'] >prep_of [lemma='binding'] >nn [lemma='ra']t?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] Gene_or_gene_producttJe2: trigger-arg-path: Binding prep_to Gene_or_gene_producttRe2: trigger-arg-path: binding:Binding prep_to Gene_or_gene_producttXe2: trigger-arg-path: binding:Binding prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: binding prep_to [lemma='raf1'] Gene_or_gene_producttPe2: trigger-arg-path: Binding prep_to theme:Gene_or_gene_productt?e2: trigger-arg-path: binding prep_to [lemma='raf1'] theme:Gene_or_gene_productt\e2: trigger-arg-path: lemmatizedTrigger=binding prep_to Gene_or_gene_producttbe2: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Gene_or_gene_productt;e2: trigger-arg-path: Binding prep_to themet)interceding-token ngrams: this calmodulintBe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT inhibited Shoc2t4interceding-token ngrams: suppressed this calmodulintUinterceding-tokens-full-span: and that Ca 2+ suppressed this calmodulin inhibition oft?e2: trigger-arg-path: Binding prep_to [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='raf1'] themetJe2: trigger-arg-path: binding prep_to Gene_or_gene_producttze2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] themet2interceding-token ngrams: calmodulin inhibition oft?e2: trigger-arg-path: binding:Binding prep_to [lemma='raf1'] theme:Gene_or_gene_producttCe2: trigger-arg-path: binding:Binding prep_to themet?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='raf1'] themet4interceding-token ngrams: this calmodulin inhibitiontQe1: trigger-arg-path: Binding prep_to [lemma='ra'] themet`e1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] Gene_or_gene_productt:e2: trigger-arg-path: increased >xcomp >dobj Generic_eventtKe2: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj Generic_eventtRe1: trigger-arg-path: binding prep_to [lemma='ra'] Familyt#interceding-token ngrams: upon W-13tinterceding-token ngrams: FRETtKe1: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Familyt4e2: ents2Label-mention-ngram: ionomycin , indicatingtfe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] theme:Gene_or_gene_producttYe1: trigger-arg-path: binding:Binding prep_to [lemma='ra'] themet5e2: ents2Label-mention-ngram: increased significantlyt.e2: ents2Label-mention-ngram: , indicating thet-e2: args2Role-mention-ngram: Shoc2 CONTROLLEDt!e2: args2Role-mention-ngram: W-13tKe2: trigger-arg-path: increased:Positive_regulation >xcomp >dobj controlledt/e2: ents2Label-mention-ngram: Shoc2 associationt)e2: ents2Label-mention-ngram: and W-13 ort3e1: trigger-arg-path: Binding prep_to Familyt?e1: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] themet(e2: args2Role-mention-ngram: and W-13 ort&interceding-token ngrams: treatment byt9e1: trigger-arg-path: Binding prep_to theme:Familyt%e2: ents2Label-mention-ngram: W-13 ortAe2: trigger-arg-path: Positive_regulation >xcomp >dobj controlledt9e2: args2Role-mention-ngram: significantly upon treatmentt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt^e1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] theme:Gene_or_gene_producttte2: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtMe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Familyte2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt'e2: ents2Label-mention-ngram: the Shoc2twe2: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt(e2: args2Role-mention-ngram: ionomycin ,t&e2: args2Role-mention-ngram: the Shoc2t1e2: args2Role-mention-ngram: the Shoc2 CONTROLLEDt+interceding-token ngrams: W-13 treatment bytNe2: trigger-arg-path: increased:Positive_regulation >xcomp >dobj Generic_eventt7e1: trigger-arg-path: binding >nn [lemma='shoc2'] themet"e2: ents2Label-mention-ngram: upontXe1: trigger-arg-path: Binding prep_to [lemma='ra'] theme:Familytte2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt"CSSPATH: ROOT >dobj ++ ROOT >ccompt9e1: trigger-arg-path: binding prep_to theme:Familytce2: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert'interceding-token ngrams: with CFP-KRast`e2: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtle1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] FamilytVe2: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj controlled:Generic_eventtDe2: trigger-arg-path: Positive_regulation >xcomp >dobj Generic_eventt/e2: ents2Label-mention-ngram: 007 and ionomycint1interceding-token ngrams: the intermolecular FRETt-interceding-token ngrams: upon W-13 treatmenttce2: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_producttxe2: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt'e2: ents2Label-mention-ngram: ionomycint9e2: args2Role-mention-ngram: increased significantly upont%interceding-token ngrams: FRET methodtXe2: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of Gene_or_gene_producttje2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj controlled:Generic_eventt?interceding-tokens-full-span: upon W-13 treatment by the intermolecular FRET method with CFP-KRas and Shoc2-YFP . We found that the level oft'interceding-token ngrams: and Shoc2-YFPt;e1: trigger-arg-path: binding:Binding prep_to Familytinterceding-token ngrams: W-13tde1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] Familytke1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] themet%interceding-token ngrams: method witht?e2: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventtce1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] themetje1: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] theme:Familytme2: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt#e2: ents2Label-mention-ngram: Shoc2tIe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] themet0interceding-token ngrams: CFP-KRas and Shoc2-YFPt/interceding-token ngrams: by the intermoleculart*interceding-token ngrams: treatment by thet+e2: args2Role-mention-ngram: upon treatmentt3e2: ents2Label-mention-ngram: the Shoc2 associationt/e2: args2Role-mention-ngram: significantly upontQe1: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] themet!e2: ents2Label-mention-ngram: 007t&e2: args2Role-mention-ngram: ionomycint_e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj Generic_eventtje2: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert4interceding-token ngrams: intermolecular FRET methodt-e2: args2Role-mention-ngram: , indicating thet%e2: args2Role-mention-ngram: and W-13t-e2: ents2Label-mention-ngram: and ionomycin ,tYe2: trigger-arg-path: increased:Positive_regulation >xcomp >dobj controlled:Generic_eventt\e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj controlledtNe1: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] Gene_or_gene_productt,e2: ents2Label-mention-ngram: upon treatmentt,interceding-token ngrams: the intermoleculart$e2: args2Role-mention-ngram: W-13 ortje2: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledt*e2: ents2Label-mention-ngram: 007 and W-13t(interceding-token ngrams: Shoc2-YFP . Wet"e2: args2Role-mention-ngram: Shoc2t1e2: args2Role-mention-ngram: indicating the Shoc2tFe1: trigger-arg-path: binding >nn [lemma='shoc2'] Gene_or_gene_producttne2: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_producttEe2: trigger-arg-path: increased >xcomp >dobj controlled:Generic_eventt"e2: ents2Label-mention-ngram: W-13t.interceding-token ngrams: method with CFP-KRastSe1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Familyt$e2: ents2Label-mention-ngram: or 007t)interceding-token ngrams: and Shoc2-YFP .t,e2: ents2Label-mention-ngram: indicating thetEe1: trigger-arg-path: lemmatizedTrigger=binding prep_to Familyt%e2: args2Role-mention-ngram: with 007tqe2: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtFe1: trigger-arg-path: Binding >nn [lemma='shoc2'] Gene_or_gene_productt0e2: ents2Label-mention-ngram: significantly upont?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtLe1: trigger-arg-path: Binding >nn [lemma='shoc2'] theme:Gene_or_gene_productt*e2: args2Role-mention-ngram: and ionomycint+e2: args2Role-mention-ngram: indicating thet,e2: args2Role-mention-ngram: and ionomycin ,tRe1: trigger-arg-path: Binding prep_to [lemma='ra'] Familyt,e2: ents2Label-mention-ngram: treatment witht%e2: ents2Label-mention-ngram: 007 andtce2: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_productt3e2: args2Role-mention-ngram: ionomycin , indicatingt(interceding-token ngrams: that the levelt interceding-token ngrams: methodt-interceding-token ngrams: intermolecular FRETt+e2: args2Role-mention-ngram: treatment witht"interceding-token ngrams: CFP-KRast/e2: args2Role-mention-ngram: treatment with 007t(e2: ents2Label-mention-ngram: or 007 andtme2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert*e2: ents2Label-mention-ngram: with 007 andt1e2: ents2Label-mention-ngram: upon treatment witht&e2: ents2Label-mention-ngram: and W-13tTe1: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] theme:Gene_or_gene_producttZe1: trigger-arg-path: binding:Binding prep_to [lemma='ra'] Familyt:e2: ents2Label-mention-ngram: significantly upon treatmentt?e2: args2Role-mention-ngram: CONTROLLER increased significantlyt+interceding-token ngrams: with CFP-KRas andtOe2: trigger-arg-path: Positive_regulation >xcomp >dobj controlled:Generic_eventtwe2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_producttNe2: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of controllert'e2: args2Role-mention-ngram: or 007 andt2e2: ents2Label-mention-ngram: indicating the Shoc2t&e2: ents2Label-mention-ngram: with 007t%interceding-token ngrams: Shoc2-YFP .tYe2: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllertXe1: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] Gene_or_gene_producttce2: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt$e2: args2Role-mention-ngram: 007 andt0e2: ents2Label-mention-ngram: treatment with 007te2: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventtte2: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt?e2: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt+e2: ents2Label-mention-ngram: and ionomycint/e1: ents2Label-mention-ngram: binding to FAMILYt?e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt#e2: args2Role-mention-ngram: or 007t)e2: args2Role-mention-ngram: 007 and W-13t*interceding-token ngrams: FRET method witht!e2: args2Role-mention-ngram: upont0e2: args2Role-mention-ngram: upon treatment withtQe1: trigger-arg-path: binding prep_to [lemma='ra'] themet e2: args2Role-mention-ngram: 007txe2: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_producttXe1: trigger-arg-path: binding prep_to [lemma='ra'] theme:FamilytAe1: trigger-arg-path: binding:Binding prep_to theme:Familyt4e2: args2Role-mention-ngram: increased significantlytre1: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] theme:FamilytJe2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT increased significantlyt7e2: trigger-arg-path: increased >xcomp >dobj controlledt(interceding-token ngrams: intermoleculart`e1: trigger-arg-path: binding:Binding prep_to [lemma='ra'] theme:Familyt.e2: args2Role-mention-ngram: 007 and ionomycint3e1: trigger-arg-path: binding prep_to Familyt)e2: ents2Label-mention-ngram: W-13 or 007t:e2: ents2Label-mention-ngram: increased significantly upontme2: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt)e2: args2Role-mention-ngram: with 007 andtHe2: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj controlledt&interceding-token ngrams: CFP-KRas andt7e1: trigger-arg-path: Binding >nn [lemma='shoc2'] themet(e2: args2Role-mention-ngram: W-13 or 007t)e2: ents2Label-mention-ngram: ionomycin ,t~e2: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert#interceding-token ngrams: Shoc2-YFPt(interceding-token ngrams: W-13 treatmenttLe1: trigger-arg-path: binding >nn [lemma='shoc2'] theme:Gene_or_gene_producttne2: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt7e2: trigger-arg-path: binding >nn [lemma='shoc2'] themet\e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:FamilytNe1: trigger-arg-path: increased:Positive_regulation >xcomp >dobj Generic_eventt$interceding-token ngrams: argue thatt'e1: args2Role-mention-ngram: or 007 andtprep_to Familytme1: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] themet&interceding-token ngrams: signaling byt7e1: trigger-arg-path: increased >xcomp >dobj controlledt"interceding-token ngrams: with Rast~e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllertqe2: trigger-arg-path: Binding prep_to [lemma='ra'] Familytce1: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert)e1: args2Role-mention-ngram: 007 and W-13t?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] theme:FamilytDe1: trigger-arg-path: Positive_regulation >xcomp >dobj Generic_eventt?e1: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt+e1: ents2Label-mention-ngram: and ionomycint#interceding-token ngrams: KRas . IntIe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] themetDe2: trigger-arg-path: binding:Binding prep_to FamilytJe1: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT increased significantlyt(e1: ents2Label-mention-ngram: or 007 andt2interceding-token ngrams: that calmodulin inhibitst+interceding-token ngrams: Shoc2 associationtJe2: trigger-arg-path: binding:Binding prep_to theme:Familyt9e1: args2Role-mention-ngram: increased significantly upont2e1: ents2Label-mention-ngram: indicating the Shoc2t)e1: args2Role-mention-ngram: with 007 andt%interceding-token ngrams: the resultst)e1: ents2Label-mention-ngram: W-13 or 007t interceding-token ngrams: KRas .t/e1: args2Role-mention-ngram: significantly upont%interceding-token ngrams: , Shoc2 andt0e1: ents2Label-mention-ngram: significantly upont-interceding-token ngrams: shown here stronglytHe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj controlledtce1: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt)interceding-token ngrams: Ras and therebyt1e1: ents2Label-mention-ngram: upon treatment withtqe2: trigger-arg-path: binding prep_to [lemma='ra'] Familyt)interceding-token ngrams: . In conclusiont)e1: ents2Label-mention-ngram: ionomycin ,tVe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj controlled:Generic_eventt-interceding-token ngrams: here strongly arguette1: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt%interceding-token ngrams: Ras to Raf1t'e2: ents2Label-mention-ngram: to FAMILYt4e1: args2Role-mention-ngram: increased significantlyt&e1: args2Role-mention-ngram: the Shoc2t/e2: ents2Label-mention-ngram: binding to FAMILYtQe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] themet(interceding-token ngrams: strongly arguet,e1: ents2Label-mention-ngram: indicating thet0interceding-token ngrams: Shoc2 association witht%e1: ents2Label-mention-ngram: W-13 ort!interceding-token ngrams: , Shoc2t-interceding-token ngrams: strongly argue thatte1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt$e1: args2Role-mention-ngram: W-13 ort/interceding-token ngrams: and thereby formationt!interceding-token ngrams: the Rast%interceding-token ngrams: 2+ enhancest,e1: ents2Label-mention-ngram: treatment witht1e1: args2Role-mention-ngram: indicating the Shoc2t:e1: ents2Label-mention-ngram: significantly upon treatmentt*e1: ents2Label-mention-ngram: , indicatingt+interceding-token ngrams: to Raf1 signalingt&interceding-token ngrams: with Ras andt*interceding-token ngrams: and Raf1 complext%interceding-token ngrams: Ras , Shoc2t)interceding-token ngrams: that calmodulint?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt*interceding-token ngrams: Raf1 complex andt3interceding-token ngrams: calmodulin inhibits Shoc2t"e1: ents2Label-mention-ngram: W-13t!e1: ents2Label-mention-ngram: 007t.e1: args2Role-mention-ngram: 007 and ionomycint3interceding-token ngrams: by suppressing calmodulint/e1: args2Role-mention-ngram: treatment with 007tinterceding-token ngrams: heret,e1: ents2Label-mention-ngram: upon treatmenttxe1: trigger-arg-path: Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt`e2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] Gene_or_gene_productt)e1: ents2Label-mention-ngram: and W-13 ortXe1: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of Gene_or_gene_productt0e1: ents2Label-mention-ngram: treatment with 007tTe2: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:Familytte1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttje1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj controlled:Generic_eventtBe2: trigger-arg-path: Binding prep_to theme:Familyt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt(e1: args2Role-mention-ngram: W-13 or 007t'interceding-token ngrams: In conclusiont-interceding-token ngrams: calmodulin inhibitst(e1: ents2Label-mention-ngram: indicatingt?e1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt3e1: args2Role-mention-ngram: ionomycin , indicatingt(interceding-token ngrams: inhibits Shoc2tprep_to Familyt$e1: ents2Label-mention-ngram: or 007twe1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt&e1: args2Role-mention-ngram: ionomycintYe1: trigger-arg-path: increased:Positive_regulation >xcomp >dobj controlled:Generic_eventt'interceding-token ngrams: here stronglyt\e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj controlledt,e1: args2Role-mention-ngram: and ionomycin ,t3e1: ents2Label-mention-ngram: the Shoc2 associationt(e1: args2Role-mention-ngram: ionomycin ,t(interceding-token ngrams: Ca 2+ enhancest?e1: args2Role-mention-ngram: CONTROLLER increased significantlyt*e1: ents2Label-mention-ngram: 007 and W-13tLe2: trigger-arg-path: Binding >nn [lemma='shoc2'] theme:Gene_or_gene_productt:e1: ents2Label-mention-ngram: increased significantly upont4e1: ents2Label-mention-ngram: ionomycin , indicatingt+interceding-token ngrams: the results shownt*e1: args2Role-mention-ngram: and ionomycint0e1: args2Role-mention-ngram: upon treatment witht4interceding-token ngrams: inhibits Shoc2 associationt'e1: args2Role-mention-ngram: indicatingt.interceding-token ngrams: thereby formation oft'e1: ents2Label-mention-ngram: the Shoc2tinterceding-token ngrams: arguetne1: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt.e1: ents2Label-mention-ngram: , indicating thet?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] Familytye2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] FamilytTe2: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] theme:Gene_or_gene_productt$interceding-token ngrams: of the Rast_e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of controllert&interceding-token ngrams: Raf1 complext?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledt#interceding-token ngrams: Shoc2 andtce1: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of controller:Gene_or_gene_producttVe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Familytme1: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt'interceding-token ngrams: , the resultst-e1: args2Role-mention-ngram: Shoc2 CONTROLLEDtie1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj >prep_of Gene_or_gene_productt?e2: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] themette1: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtYe1: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllertccomp ++ ROOT >ccomp >prepc_by >dobj >prep_oft'e1: ents2Label-mention-ngram: ionomycint3interceding-token ngrams: suppressing calmodulin 'st(e1: args2Role-mention-ngram: and W-13 ort:e1: trigger-arg-path: increased >xcomp >dobj Generic_eventt*e1: ents2Label-mention-ngram: with 007 andtqe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledt)interceding-token ngrams: In conclusion ,t/e1: ents2Label-mention-ngram: Shoc2 associationt%e1: args2Role-mention-ngram: and W-13t(interceding-token ngrams: Raf1 signalingt)interceding-token ngrams: 2+ enhances RastLe2: trigger-arg-path: binding >nn [lemma='shoc2'] theme:Gene_or_gene_productt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] themet&interceding-token ngrams: enhances RastBe2: trigger-arg-path: binding prep_to theme:FamilytNe2: trigger-arg-path: binding:Binding >nn [lemma='shoc2'] Gene_or_gene_productt%interceding-token ngrams: with KRas .tOe1: trigger-arg-path: Positive_regulation >xcomp >dobj controlled:Generic_eventt2interceding-token ngrams: calmodulin 's inhibitiont'interceding-token ngrams: results shownt&e1: ents2Label-mention-ngram: and W-13twe2: trigger-arg-path: Binding prep_to [lemma='ra'] theme:Familyt%e1: ents2Label-mention-ngram: 007 andtje1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert$e1: args2Role-mention-ngram: 007 andt0interceding-token ngrams: suppressing calmodulintNe1: trigger-arg-path: increased:Positive_regulation >nsubj >prep_of controllert/interceding-token ngrams: argue that calmodulinte1: trigger-arg-path: lemmatizedTrigger=increase >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt%e1: args2Role-mention-ngram: with 007t#e1: args2Role-mention-ngram: or 007t e1: args2Role-mention-ngram: 007tce1: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_producttte1: trigger-arg-path: lemmatizedTrigger=increase >nsubj [lemma='level'] >prep_of [lemma='FRET'] Gene_or_gene_productt(interceding-token ngrams: Shoc2 and Raf1t2interceding-token ngrams: signaling by suppressingt`e1: trigger-arg-path: increased >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledtpe2: trigger-arg-path: Binding prep_to [lemma='ra'] themet/e1: ents2Label-mention-ngram: 007 and ionomycint-e1: args2Role-mention-ngram: , indicating thet+interceding-token ngrams: Raf1 signaling bytwe2: trigger-arg-path: binding prep_to [lemma='ra'] theme:Familyt,interceding-token ngrams: results shown heret(interceding-token ngrams: by suppressingt+e1: args2Role-mention-ngram: upon treatmentt-e1: ents2Label-mention-ngram: and ionomycin ,txe1: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlled:Generic_eventt?e2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] Familytxe2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] themetje1: trigger-arg-path: Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] controlledt7e2: trigger-arg-path: Binding >nn [lemma='shoc2'] themet)interceding-token ngrams: enhances Ras tot!e1: args2Role-mention-ngram: W-13tXe2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] Gene_or_gene_productt^e2: trigger-arg-path: lemmatizedTrigger=binding >nn [lemma='shoc2'] theme:Gene_or_gene_producttFe2: trigger-arg-path: binding >nn [lemma='shoc2'] Gene_or_gene_productt?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt#interceding-token ngrams: the Ras ,tNe2: trigger-arg-path: lemmatizedTrigger=binding prep_to Familyt_e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >xcomp >dobj Generic_eventt+e1: args2Role-mention-ngram: indicating thetfe2: trigger-arg-path: lemmatizedTrigger=binding:Binding >nn [lemma='shoc2'] theme:Gene_or_gene_productte2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] theme:Familytpe2: trigger-arg-path: binding prep_to [lemma='ra'] themetne1: trigger-arg-path: increased >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt)e1: args2Role-mention-ngram: , indicatingtFe2: trigger-arg-path: Binding >nn [lemma='shoc2'] Gene_or_gene_productt#interceding-token ngrams: with KRast5e1: ents2Label-mention-ngram: increased significantlyt*interceding-token ngrams: conclusion , thet$interceding-token ngrams: shown heret+e1: args2Role-mention-ngram: treatment witht?e2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] theme:FamilytKe1: trigger-arg-path: lemmatizedTrigger=increase >xcomp >dobj Generic_eventt9e1: args2Role-mention-ngram: significantly upon treatmentt&interceding-token ngrams: conclusion ,t?e1: trigger-arg-path: lemmatizedTrigger=increase:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controller:Gene_or_gene_productt!interceding-token ngrams: to Raf1t.interceding-token ngrams: association with Rast'interceding-token ngrams: calmodulin 'stwe1: trigger-arg-path: increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] Generic_eventt&interceding-tokens-full-span: with KRas . In conclusion , the results shown here strongly argue that calmodulin inhibits Shoc2 association with Ras and thereby formation of the Ras , Shoc2 and Raf1 complex and that Ca 2+ enhances Ras to Raf1 signaling by suppressing calmodulin 's inhibition oft1e1: args2Role-mention-ngram: the Shoc2 CONTROLLEDt&e1: ents2Label-mention-ngram: with 007tKe1: trigger-arg-path: increased:Positive_regulation >xcomp >dobj controlledtEe1: trigger-arg-path: increased >xcomp >dobj controlled:Generic_eventtme1: trigger-arg-path: increased:Positive_regulation >nsubj [lemma='level'] >prep_of [lemma='FRET'] controllert=e2: ents2Label-mention-ngram: GENE_OR_GENE_PRODUCT binding tot+interceding-token ngrams: thereby formationt)e2: args2Role-mention-ngram: enhances Rast-e2: args2Role-mention-ngram: 's inhibition oft7e2: ents2Label-mention-ngram: suppressing calmodulin 'st?interceding-tokens-full-span: with KRas . In conclusion , the results shown here strongly argue that calmodulin inhibits Shoc2 association with Ras and thereby formation of the Ras , Shoc2 and Raf1 complex and thattSe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='ca'] Simple_chemicaltVe2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='ca'] Simple_chemicaltFe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj Simple_chemicaltge2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='ca'] Simple_chemicalt.e2: args2Role-mention-ngram: to Raf1 signalingt*e2: args2Role-mention-ngram: 's inhibitiont*e2: ents2Label-mention-ngram: signaling bytre2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='ca'] controller:Simple_chemicalt)e2: ents2Label-mention-ngram: Ras to Raf1tZe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj Simple_chemicalt5e2: trigger-arg-path: enhances >nsubj Simple_chemicalt)e2: ents2Label-mention-ngram: 2+ enhancest3e2: args2Role-mention-ngram: suppressing calmodulint6e2: ents2Label-mention-ngram: signaling by suppressingt+e2: args2Role-mention-ngram: by suppressingt3e2: args2Role-mention-ngram: CONTROLLER 2+ enhancest,e2: ents2Label-mention-ngram: by suppressingt/e2: ents2Label-mention-ngram: to Raf1 signalingt)e2: ents2Label-mention-ngram: suppressingt6e2: ents2Label-mention-ngram: calmodulin 's inhibitiont+e2: ents2Label-mention-ngram: 's inhibitiont!e2: args2Role-mention-ngram: Raf1tXe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ca'] controller:Simple_chemicalt5e2: args2Role-mention-ngram: calmodulin 's inhibitiont)e2: args2Role-mention-ngram: signaling byt-e2: ents2Label-mention-ngram: 2+ enhances Rast%e2: ents2Label-mention-ngram: to Raf1tQe2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='ca'] controllert@e2: ents2Label-mention-ngram: inhibition of GENE_OR_GENE_PRODUCTtTe2: trigger-arg-path: enhances:Positive_regulation >nsubj controller:Simple_chemicalt(e2: args2Role-mention-ngram: Ras to Raf1tQe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj controller:Simple_chemicalt,e2: args2Role-mention-ngram: 2+ enhances Rast*e2: args2Role-mention-ngram: calmodulin 'stMe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ca'] Simple_chemicalt5e2: args2Role-mention-ngram: signaling by suppressingt(e2: args2Role-mention-ngram: 2+ enhancest(e2: ents2Label-mention-ngram: calmodulint.e2: args2Role-mention-ngram: Raf1 signaling byt=e2: trigger-arg-path: enhances >nsubj [lemma='ca'] controllertNe2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='ca'] controllertee2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj controller:Simple_chemicalt(e2: args2Role-mention-ngram: suppressingt'e2: args2Role-mention-ngram: calmodulint$e2: args2Role-mention-ngram: to Raf1t6e2: args2Role-mention-ngram: by suppressing calmodulintbe2: trigger-arg-path: lemmatizedTrigger=enhance:Positive_regulation >nsubj [lemma='ca'] controllert6e2: args2Role-mention-ngram: suppressing calmodulin 'st-e2: ents2Label-mention-ngram: enhances Ras tot^e2: trigger-arg-path: lemmatizedTrigger=enhance >nsubj [lemma='ca'] controller:Simple_chemicalt+e2: ents2Label-mention-ngram: calmodulin 'st7e2: ents2Label-mention-ngram: by suppressing calmodulint"e2: ents2Label-mention-ngram: Raf1t*e2: ents2Label-mention-ngram: enhances RastBe2: trigger-arg-path: enhances >nsubj [lemma='ca'] Simple_chemicalt4e2: ents2Label-mention-ngram: suppressing calmodulint9e2: ents2Label-mention-ngram: SIMPLE_CHEMICAL 2+ enhancestMe2: trigger-arg-path: enhances >nsubj [lemma='ca'] controller:Simple_chemicalt.e2: ents2Label-mention-ngram: 's inhibition oft=e2: ents2Label-mention-ngram: of GENE_OR_GENE_PRODUCT bindingt,e2: args2Role-mention-ngram: enhances Ras tot@e2: trigger-arg-path: enhances >nsubj controller:Simple_chemicaltIe2: trigger-arg-path: enhances:Positive_regulation >nsubj Simple_chemicalt,e2: ents2Label-mention-ngram: Raf1 signalingtae2: trigger-arg-path: enhances:Positive_regulation >nsubj [lemma='ca'] controller:Simple_chemicaltHe2: trigger-arg-path: Positive_regulation >nsubj [lemma='ca'] controllert+e2: args2Role-mention-ngram: Raf1 signalingt/e2: ents2Label-mention-ngram: Raf1 signaling bytSe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to theme:Familytctrigger-to-trigger-path: e1:increased:Positive_regulation >xcomp >dobj e2:association:Generic_eventtYe2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] themet+shortest-path: xcomp >dobjt3e2: trigger-arg-path: binding prep_to Familytwshortest-path: xcomp [lemma='indicate'] >dobj [lemma='association']tje2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] theme:Familyt;e2: trigger-arg-path: binding:Binding prep_to FamilytEe2: trigger-arg-path: lemmatizedTrigger=binding prep_to FamilytKe2: trigger-arg-path: lemmatizedTrigger=binding prep_to theme:FamilytRe2: trigger-arg-path: Binding prep_to [lemma='ra'] FamilytAe2: trigger-arg-path: binding:Binding prep_to theme:FamilytXe2: trigger-arg-path: Binding prep_to [lemma='ra'] theme:Familytde2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] FamilytMe2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to Familytle2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] Familyt3e2: trigger-arg-path: Binding prep_to Familyt`e2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] theme:Familytce2: trigger-arg-path: lemmatizedTrigger=binding prep_to [lemma='ra'] themet9e2: trigger-arg-path: binding prep_to theme:Familytke2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] themetQe2: trigger-arg-path: binding prep_to [lemma='ra'] themet9e2: trigger-arg-path: Binding prep_to theme:FamilytZe2: trigger-arg-path: binding:Binding prep_to [lemma='ra'] FamilytRe2: trigger-arg-path: binding prep_to [lemma='ra'] Familytre2: trigger-arg-path: lemmatizedTrigger=binding:Binding prep_to [lemma='ra'] theme:Familyt?trigger-to-trigger-path: e1:increased:Positive_regulation >xcomp [lemma='indicate'] >dobj [lemma='association'] e2:association:Generic_eventtQe2: trigger-arg-path: Binding prep_to [lemma='ra'] themetXe2: trigger-arg-path: binding prep_to [lemma='ra'] theme:Familypppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppp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